                         SEQUENCE LISTING

<110>  Centre national de la recherche scientifique
 
<120>  Method for obtaining haploid cells

<130>  B374665D38055

<150>  EP 17305841.3
<151>  2017-06-30

<160>  12    

<170>  PatentIn version 3.5

<210>  1
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  murine deletion box

<400>  1

Arg Arg Thr Leu Lys Met Ile Gln Pro 
1               5                   


<210>  2
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  consensus degradation box


<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa = L or V

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa = Leu  or Val

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  Xaa can be any naturally occurring amino acid

<400>  2

Arg Xaa Thr Leu Lys Xaa Xaa Gln Xaa 
1               5                   


<210>  3
<211>  209
<212>  PRT
<213>  consensus deletion box

<400>  3

Met Asn Pro Ser Met Lys Gln Lys Gln Glu Glu Ile Lys Glu Asn Ile 
1               5                   10                  15      


Lys Asn Ser Ser Val Pro Arg Arg Thr Leu Lys Met Ile Gln Pro Ser 
            20                  25                  30          


Ala Ser Gly Ser Leu Val Gly Arg Glu Asn Glu Leu Ser Ala Gly Leu 
        35                  40                  45              


Ser Lys Arg Lys His Arg Asn Asp His Leu Thr Ser Thr Thr Ser Ser 
    50                  55                  60                  


Pro Gly Val Ile Val Pro Glu Ser Ser Glu Asn Lys Asn Leu Gly Gly 
65                  70                  75                  80  


Val Thr Gln Glu Ser Phe Asp Leu Met Ile Lys Glu Asn Pro Ser Ser 
                85                  90                  95      


Gln Tyr Trp Lys Glu Val Ala Glu Lys Arg Arg Lys Ala Leu Tyr Glu 
            100                 105                 110         


Ala Leu Lys Glu Asn Glu Lys Leu His Lys Glu Ile Glu Gln Lys Asp 
        115                 120                 125             


Asn Glu Ile Ala Arg Leu Lys Lys Glu Asn Lys Glu Leu Ala Glu Val 
    130                 135                 140                 


Ala Glu His Val Gln Tyr Met Ala Glu Leu Ile Glu Arg Leu Asn Gly 
145                 150                 155                 160 


Glu Pro Leu Asp Asn Phe Glu Ser Leu Asp Asn Gln Glu Phe Asp Ser 
                165                 170                 175     


Glu Glu Glu Thr Val Glu Asp Ser Leu Val Glu Asp Ser Glu Ile Gly 
            180                 185                 190         


Thr Cys Ala Glu Gly Thr Val Ser Ser Ser Thr Asp Ala Lys Pro Cys 
        195                 200                 205             


Ile 
    


<210>  4
<211>  206
<212>  PRT
<213>  Mus musculus

<400>  4

Met Asn Leu Ser Met Lys Gln Lys Gln Glu Gly Ala Gln Glu Asn Val 
1               5                   10                  15      


Lys Asn Ser Pro Val Pro Arg Arg Thr Leu Lys Met Ile Gln Pro Ser 
            20                  25                  30          


Ala Asp Gly Ser Leu Val Gly Arg Glu Asn Glu Leu Pro Lys Gly Leu 
        35                  40                  45              


Phe Lys Arg Lys Leu Trp Asp Asp Gln Leu Ala Ser Gln Thr Ser Ser 
    50                  55                  60                  


Cys Gly Pro Glu Ala Asn Glu Asn Lys Asp Val Gly Asp Leu Thr Gln 
65                  70                  75                  80  


Glu Ala Phe Asp Leu Ile Ser Lys Glu Asn Pro Ser Ser Gln Tyr Trp 
                85                  90                  95      


Lys Glu Val Ala Glu Gln Arg Arg Lys Ala Leu Tyr Glu Ala Leu Lys 
            100                 105                 110         


Glu Asn Glu Lys Leu His Lys Glu Ile Glu Gln Lys Asp Ser Glu Ile 
        115                 120                 125             


Ala Arg Leu Arg Lys Glu Asn Lys Asp Leu Ala Glu Val Ala Glu His 
    130                 135                 140                 


Val Gln Tyr Met Ala Glu Val Ile Glu Arg Leu Ser Asn Glu Pro Leu 
145                 150                 155                 160 


Asp Asn Phe Glu Ser Pro Asp Ser Gln Glu Phe Asp Ser Glu Glu Glu 
                165                 170                 175     


Ala Val Glu Tyr Ser Glu Leu Glu Asp Ser Gly Ala Gly Thr Cys Ala 
            180                 185                 190         


Glu Glu Thr Val Ser Ser Ser Thr Asp Ala Arg Pro Cys Thr 
        195                 200                 205     


<210>  5
<211>  216
<212>  PRT
<213>  Xenopus laevis

<400>  5

Met Asn Ser Asn Met Lys Gln Arg Ser Asp Val Glu Asn Pro Ser Met 
1               5                   10                  15      


Ser Ile Lys Asn Tyr Ile Val Asp Lys Thr Asn Glu Ala Leu Ala Pro 
            20                  25                  30          


Arg Arg Thr Leu Lys Val Ile Gln Gln Ser Ala Ser Gly Cys Leu Val 
        35                  40                  45              


Gly Arg Thr Lys Glu Pro Ala Lys Asn Ser Thr Lys Arg Lys Leu Trp 
    50                  55                  60                  


Asn Asp Gln Leu Thr Ser Lys Lys Ala Lys Val Glu Val Ala Val Asp 
65                  70                  75                  80  


Pro Glu His Gln Glu Asn Lys Asp Cys Pro Ser Glu Ala Tyr Asp Leu 
                85                  90                  95      


Met Val Lys Glu Thr Pro Thr Cys Leu Tyr Trp Lys Asp Val Ala Glu 
            100                 105                 110         


Glu Arg Arg Lys Ala Leu Tyr Glu Ala Leu Gln Glu Asn Glu Lys Leu 
        115                 120                 125             


His Gln Glu Ile Glu Leu Lys Asp Glu Glu Ile Ala Arg Leu Lys Gln 
    130                 135                 140                 


Glu Asn Asp Glu Leu Met Glu Leu Ala Gly His Val Gln Tyr Met Ala 
145                 150                 155                 160 


Asn Met Ile Glu Arg Leu Thr Gly Asn Ala Pro Gln Ser Leu Glu Asp 
                165                 170                 175     


Leu Lys Asn Leu Asp Leu Glu Glu Ala Arg Phe Glu Asp Glu Ala Glu 
            180                 185                 190         


Ser Arg Ile Glu Asp Glu Thr Asp Met Thr Gln Pro Ser Ser Ser Asp 
        195                 200                 205             


Gln Asn Met Asp Lys Gln Thr Val 
    210                 215     


<210>  6
<211>  219
<212>  PRT
<213>  Xenopus laevis

<400>  6

Met Asn Thr Asn Lys Lys Gln Arg Leu Asp Met Glu Lys Pro Thr Met 
1               5                   10                  15      


Ser Ile Lys Asn Tyr Phe Val Asp Lys Thr Asn Glu Ser Leu Ala Pro 
            20                  25                  30          


Arg Arg Thr Leu Lys Val Ile Gln Pro Ser Ala Ser Gly Cys Leu Val 
        35                  40                  45              


Gly Arg Thr Lys Glu Pro Val Lys Asn Ser Thr Lys Arg Lys Leu Trp 
    50                  55                  60                  


Asn Asp Gln Leu Thr Ser Lys Lys Ala Lys Val Glu Val Ala Val Asp 
65                  70                  75                  80  


Pro Glu His Arg Glu Asn Lys Asp Cys Ser Ser Glu Ala Tyr Asp Leu 
                85                  90                  95      


Met Val Lys Glu Thr Pro Thr Cys Leu Tyr Trp Lys Glu Val Ala Glu 
            100                 105                 110         


Glu Arg Arg Lys Ala Leu Tyr Glu Ala Leu Gln Glu Asn Glu Lys Leu 
        115                 120                 125             


His Lys Glu Ile Glu Leu Lys Asp Glu Glu Ile Ala Arg Leu Lys Gln 
    130                 135                 140                 


Glu Asn Asp Glu Leu Met Glu Leu Ala Gly His Val Gln Tyr Met Ala 
145                 150                 155                 160 


Asn Met Ile Glu Arg Leu Thr Gly Asn Ala Pro Arg Ser Leu Glu Asp 
                165                 170                 175     


Leu Lys Asp Leu Asp Leu Glu Glu Ala Arg Phe Glu Asp Glu Ala Asp 
            180                 185                 190         


Met Ala Glu Ala Arg Ile Glu Asp Glu Thr Asp Met Ala Arg Pro Ser 
        195                 200                 205             


Asn Ser Asp Gln Asn Met Asp Ala His Thr Val 
    210                 215                 


<210>  7
<211>  192
<212>  PRT
<213>  Xenopus laevis

<400>  7

Met Ser Ser Ser Ala Ala Arg Val Tyr Ile Gln Val Glu Thr Glu Ala 
1               5                   10                  15      


Glu Gln Lys Glu His Leu Lys Gln Gln Arg Gln Thr Leu Lys Pro Leu 
            20                  25                  30          


Gln Gly Asn Val Asn Asp Lys Glu Asn Leu Thr Gly Ser Gly Arg Ala 
        35                  40                  45              


Ser Ile Val Asp Gln Leu Ser Arg Leu Lys Ala Gly Val Gln Val Ala 
    50                  55                  60                  


Pro Lys Tyr Gly Lys Arg Lys Cys Val Asp Thr Ala Pro Ala Ile Ser 
65                  70                  75                  80  


Thr Lys Asp Ala Asp Thr Gln Thr Asp Ala Glu Ala Val Pro Leu Gly 
                85                  90                  95      


Asn Ala Asp Lys Pro Ile Thr Ala Glu Asp Leu Thr Ser Thr Ala Glu 
            100                 105                 110         


Pro Gly Glu Asn Tyr Tyr Lys Leu Leu Ala Glu Gln Arg Arg Leu Ala 
        115                 120                 125             


Leu Glu Asp Ser Leu Thr Glu Asn Arg His Leu His Glu Arg Ile Glu 
    130                 135                 140                 


Gly Leu Glu Glu Glu Met Asp Thr Met Arg Gln Glu Leu Asp Glu Ala 
145                 150                 155                 160 


Lys Asn Leu Val Glu Val Leu Lys Glu Ile Cys Glu Glu Asp Asn Ser 
                165                 170                 175     


Glu Val Glu Glu Asp Asp Thr Thr Gly Asp Glu Asp Lys Val Asn Ala 
            180                 185                 190         


<210>  8
<211>  192
<212>  PRT
<213>  Xenopus laevis

<400>  8

Met Ser Ser Ser Ala Ala Arg Val Tyr Ile Gln Val Glu Thr Glu Ala 
1               5                   10                  15      


Glu Gln Lys Glu His Leu Lys Gln Gln Arg Gln Thr Leu Lys Pro Leu 
            20                  25                  30          


Gln Gly Asn Val Asn Asp Lys Glu Asn Leu Thr Gly Ser Gly Arg Ala 
        35                  40                  45              


Ser Ile Val Asp Gln Leu Ser Arg Leu Lys Ala Gly Val Gln Val Ala 
    50                  55                  60                  


Pro Lys Tyr Gly Lys Arg Lys Cys Val Asp Thr Ala Pro Ala Ile Ser 
65                  70                  75                  80  


Thr Lys Asp Ala Asp Thr Gln Thr Asp Ala Glu Ala Val Pro Leu Gly 
                85                  90                  95      


Asn Ala Asp Lys Pro Ile Thr Ala Glu Asp Leu Thr Ser Thr Ala Glu 
            100                 105                 110         


Pro Gly Glu Asn Tyr Tyr Lys Leu Leu Ala Glu Gln Arg Arg Leu Ala 
        115                 120                 125             


Leu Glu Asp Ser Leu Thr Glu Asn Arg His Leu His Glu Arg Ile Glu 
    130                 135                 140                 


Gly Leu Glu Glu Glu Met Asp Thr Met Arg Gln Glu Leu Asp Glu Ala 
145                 150                 155                 160 


Lys Asn Leu Val Glu Val Leu Lys Glu Ile Cys Glu Glu Asp Asn Ser 
                165                 170                 175     


Glu Val Glu Glu Asp Asp Thr Thr Gly Asp Glu Asp Lys Val Asn Ala 
            180                 185                 190         


<210>  9
<211>  201
<212>  PRT
<213>  Mus musculus

<400>  9

Met Asn Leu Ser Met Lys Gln Lys Gln Glu Gly Ala Gln Glu Asn Val 
1               5                   10                  15      


Lys Asn Ser Pro Val Pro Ala Ala Ala Pro Ser Ala Asp Gly Ser Leu 
            20                  25                  30          


Val Gly Arg Glu Asn Glu Leu Pro Lys Gly Leu Phe Lys Arg Lys Leu 
        35                  40                  45              


Trp Asp Asp Gln Leu Ala Ser Gln Thr Ser Ser Cys Gly Pro Glu Ala 
    50                  55                  60                  


Asn Glu Asn Lys Asp Val Gly Asp Leu Thr Gln Glu Ala Phe Asp Leu 
65                  70                  75                  80  


Ile Ser Lys Glu Asn Pro Ser Ser Gln Tyr Trp Lys Glu Val Ala Glu 
                85                  90                  95      


Gln Arg Arg Lys Ala Leu Tyr Glu Ala Leu Lys Glu Asn Glu Lys Leu 
            100                 105                 110         


His Lys Glu Ile Glu Gln Lys Asp Ser Glu Ile Ala Arg Leu Arg Lys 
        115                 120                 125             


Glu Asn Lys Asp Leu Ala Glu Val Ala Glu His Val Gln Tyr Met Ala 
    130                 135                 140                 


Glu Val Ile Glu Arg Leu Ser Asn Glu Pro Leu Asp Asn Phe Glu Ser 
145                 150                 155                 160 


Pro Asp Ser Gln Glu Phe Asp Ser Glu Glu Glu Ala Val Glu Tyr Ser 
                165                 170                 175     


Glu Leu Glu Asp Ser Gly Ala Gly Thr Cys Ala Glu Glu Thr Val Ser 
            180                 185                 190         


Ser Ser Thr Asp Ala Arg Pro Cys Thr 
        195                 200     


<210>  10
<211>  204
<212>  PRT
<213>  homo sapiens

<400>  10

Met Asn Pro Ser Met Lys Gln Lys Gln Glu Glu Ile Lys Glu Asn Ile 
1               5                   10                  15      


Lys Asn Ser Ser Val Pro Ala Ala Ala Pro Ser Ala Ser Gly Ser Leu 
            20                  25                  30          


Val Gly Arg Glu Asn Glu Leu Ser Ala Gly Leu Ser Lys Arg Lys His 
        35                  40                  45              


Arg Asn Asp His Leu Thr Ser Thr Thr Ser Ser Pro Gly Val Ile Val 
    50                  55                  60                  


Pro Glu Ser Ser Glu Asn Lys Asn Leu Gly Gly Val Thr Gln Glu Ser 
65                  70                  75                  80  


Phe Asp Leu Met Ile Lys Glu Asn Pro Ser Ser Gln Tyr Trp Lys Glu 
                85                  90                  95      


Val Ala Glu Lys Arg Arg Lys Ala Leu Tyr Glu Ala Leu Lys Glu Asn 
            100                 105                 110         


Glu Lys Leu His Lys Glu Ile Glu Gln Lys Asp Asn Glu Ile Ala Arg 
        115                 120                 125             


Leu Lys Lys Glu Asn Lys Glu Leu Ala Glu Val Ala Glu His Val Gln 
    130                 135                 140                 


Tyr Met Ala Glu Leu Ile Glu Arg Leu Asn Gly Glu Pro Leu Asp Asn 
145                 150                 155                 160 


Phe Glu Ser Leu Asp Asn Gln Glu Phe Asp Ser Glu Glu Glu Thr Val 
                165                 170                 175     


Glu Asp Ser Leu Val Glu Asp Ser Glu Ile Gly Thr Cys Ala Glu Gly 
            180                 185                 190         


Thr Val Ser Ser Ser Thr Asp Ala Lys Pro Cys Ile 
        195                 200                 


<210>  11
<211>  606
<212>  DNA
<213>  Mus musculus

<400>  11
atgaatctca gtatgaagca gaagcaggag ggagcccaag agaatgtgaa gaatagtcct       60

gtcccagcgg ccgcgccttc tgcagatgga tctcttgttg gcagagaaaa tgagttgcca      120

aaaggcttgt tcaaaaggaa gctttgggat gaccagctag catctcagac ttcaagctgt      180

ggtccagaag ctaatgaaaa taaggatgtt ggagacctca cccaggaagc ctttgatctt      240

ataagtaaag agaacccatc ttctcagtat tggaaagaag tggcagagca gcggaggaaa      300

gctctctacg aagcactgaa agagaatgag aaacttcata aagaaattga acaaaaggac      360

agtgagattg cccgcctgag aaaggagaat aaagacttgg cagaagtagc tgagcacgtg      420

cagtacatgg cggaggtaat cgagaggctg agtaatgaac ctctggataa ctttgaatca      480

ccggatagtc aggaatttga ttctgaagaa gaagctgttg agtattcaga actggaagac      540

tcaggagctg ggacgtgtgc tgaagagact gtgtcttcct ccacggatgc caggccgtgt      600

acatga                                                                 606


<210>  12
<211>  690
<212>  DNA
<213>  mus musculus

<400>  12
atgaccatgg actacaagga cgacgatgac aagctcgatg gaggataccc ctacgacgtg       60

cccgactacg ccggaggact cgagatgaat ctcagtatga agcagaagca ggagggagcc      120

caagagaatg tgaagaatag tcctgtccca gcggccgcgc cttctgcaga tggatctctt      180

gttggcagag aaaatgagtt gccaaaaggc ttgttcaaaa ggaagctttg ggatgaccag      240

ctagcatctc agacttcaag ctgtggtcca gaagctaatg aaaataagga tgttggagac      300

ctcacccagg aagcctttga tcttataagt aaagagaacc catcttctca gtattggaaa      360

gaagtggcag agcagcggag gaaagctctc tacgaagcac tgaaagagaa tgagaaactt      420

cataaagaaa ttgaacaaaa ggacagtgag attgcccgcc tgagaaagga gaataaagac      480

ttggcagaag tagctgagca cgtgcagtac atggcggagg taatcgagag gctgagtaat      540

gaacctctgg ataactttga atcaccggat agtcaggaat ttgattctga agaagaagct      600

gttgagtatt cagaactgga agactcagga gctgggacgt gtgctgaaga gactgtgtct      660

tcctccacgg atgccaggcc gtgtacatga                                       690


