               SEQUENCE LISTING

<110> FrieslandCampina Nederland B.V.

<120> Method for preparing GOS having reduced allergenicity

<160> 16

<170> BiSSAP 1.3.6

<210> 1
<211> 696
<212> PRT
<213> Cryptococcus terrestris


<400> 1
Met Ile Pro Ala Ser Ala Leu Leu Ala Ala Val Pro Leu Leu Ala Gln 
1               5                   10                  15      
Gln Val Ser Ala Gly Ile Leu Arg Arg Gln Asn Ala Ala Gly Ser Asp 
            20                  25                  30          
Ser Ala Ala Pro Asp Ser Ile Ala Asp Ala Ser Thr Gly Val Val Ser 
        35                  40                  45              
Ser Ile Ala Thr Glu Ala Val Ser Ser Gly Ala Thr Gly Leu Val Ala 
    50                  55                  60                  
Ser Val Ala Met Ser Phe Ala Ser Ser Met Ala Thr Pro Thr Ala Thr 
65                  70                  75                  80  
Val Thr Gly Leu Ser Ser Glu Thr Gly Ala Pro Ser Asn Thr Pro Met 
                85                  90                  95      
Ala Ser Ala Ser Gly Ser Val Pro Thr Thr Thr Ser Ala Val Gly Ser 
            100                 105                 110         
Gly Asp Phe Asp Trp Val Gln Thr Asp Gly Leu Pro Thr Ile Thr Thr 
        115                 120                 125             
Thr Leu Ala Thr Thr Asn Gln Asp Ala Ile Thr Pro Thr Ala Thr Gly 
    130                 135                 140                 
Pro Val Gly Gly Gln Gly Thr Pro Ala Val Asn Phe Thr Asp Tyr Ser 
145                 150                 155                 160 
Ser Ser Ser Leu Glu Gln Phe Trp Asn Asp Trp Val Gly Glu Val Glu 
                165                 170                 175     
Glu Pro Pro Phe Ala Tyr Val Pro Glu Pro Pro Asn Pro Tyr Pro Leu 
            180                 185                 190         
Pro Asn Ala Pro Pro Pro Ile Tyr Pro Glu Tyr Tyr Thr Lys Arg Pro 
        195                 200                 205             
Lys Asp Ile Leu Pro Asp Tyr Lys Phe Pro Lys Asp Phe Leu Phe Gly 
    210                 215                 220                 
Trp Ala Thr Ala Ala Gln Gln Trp Glu Gly Ala Val Lys Ala Asp Gly 
225                 230                 235                 240 
Lys Gly Pro Ser Ile Trp Asp Trp Ala Ser Arg Phe Pro Gly Phe Ile 
                245                 250                 255     
Ala Asp Asn Thr Thr Ser Asp Val Gly Asp Leu Gly Tyr Tyr Leu Tyr 
            260                 265                 270         
Lys Glu Asp Leu Ala Arg Ile Ala Ala Leu Gly Ala Asn Val Tyr Ser 
        275                 280                 285             
Phe Ser Met Phe Trp Thr Arg Ile Phe Pro Phe Gly Lys Ala Asp Ser 
    290                 295                 300                 
Pro Val Asn Gln Ala Gly Ile Asp Phe Tyr His Asp Leu Ile Asp Tyr 
305                 310                 315                 320 
Ser Trp Ser Leu Gly Ile Glu Pro Val Val Thr Leu Phe His Trp Asp 
                325                 330                 335     
Thr Pro Leu Ala Leu Gln Leu Glu Tyr Gly Gly Phe Ala Ser Glu Arg 
            340                 345                 350         
Ile Ile Asp Asp Tyr Val Asn Tyr Ala Glu Thr Val Phe Lys Ala Tyr 
        355                 360                 365             
Asn Gly Ser Val His Lys Trp Val Thr Phe Asn Glu Pro Val Val Phe 
    370                 375                 380                 
Cys Ser Gln Met Ala Ala Pro Val Asn Thr Thr Leu Pro Pro Asn Leu 
385                 390                 395                 400 
Asn Ser Thr Ile Tyr Pro Tyr Thr Cys Ser Tyr His Leu Val Leu Ala 
                405                 410                 415     
His Ala Lys Thr Val Lys Arg Phe Arg Glu Leu Asn Ile Gln Gly Gln 
            420                 425                 430         
Ile Ala Phe Lys Ser Asp Asn Phe Val Gly Ile Pro Trp Arg Glu Gly 
        435                 440                 445             
Asn Gln Glu Asp Ile Asp Ala Val Glu Arg His Gln Ala Tyr Gln Ile 
    450                 455                 460                 
Gly Ile Phe Ala Glu Pro Ile Tyr Asn Thr Gly Asp Trp Pro Asp Ile 
465                 470                 475                 480 
Val Lys Asn Asp Leu Ser Pro Asp Ile Leu Pro Arg Phe Thr Asp Asp 
                485                 490                 495     
Glu Ile Ala Met Ile Lys Cys Thr Ala Asp Phe Phe Pro Ile Asp Gly 
            500                 505                 510         
Tyr Arg Asp Gly Tyr Val Gln Ala Val Pro Gly Gly Val Glu Ala Cys 
        515                 520                 525             
Val Ala Asn Ile Ser Asn Pro Leu Trp Pro Ala Cys Asn Gln Val Asn 
    530                 535                 540                 
Phe Tyr Asp Ser Thr Pro Ala Gly Trp Ala Ile Gly Thr Phe Gly Asn 
545                 550                 555                 560 
Trp Pro Thr Thr Pro Trp Leu Gln Asn Thr Trp Gln Phe Val Arg Pro 
                565                 570                 575     
Phe Leu Ala Asp Leu Ala Lys Arg Tyr Pro Thr Glu Gly Gly Ile Tyr 
            580                 585                 590         
Leu Ser Glu Phe Gly Phe Ser Glu Pro Phe Glu Asn Asp Lys Thr Phe 
        595                 600                 605             
Ile Tyr Gln Ile Thr Gln Asp Ser Gly Arg Thr Ala Tyr Phe Asn Ser 
    610                 615                 620                 
Tyr Leu Gly Glu Val Leu Lys Gly Ile Val Glu Asp Gly Ile Pro Ile 
625                 630                 635                 640 
Lys Gly Val Phe Gly Trp Ser Met Val Asp Asn Phe Glu Trp Asn Ser 
                645                 650                 655     
Gly Leu Ser Thr Arg Phe Gly Val Gln Tyr Val Asp Tyr Asn Ser Pro 
            660                 665                 670         
Thr Arg Gln Arg Thr Phe Lys Arg Ser Ala Leu Glu Met Ser Glu Phe 
        675                 680                 685             
Trp Asn Ala His Arg Cys Ser Ala 
    690                 695     

<210> 2
<211> 566
<212> PRT
<213> Cryptococcus terrestris


<400> 2
Ala Thr Thr Asn Gln Asp Ala Ile Thr Pro Thr Ala Thr Gly Pro Val 
1               5                   10                  15      
Gly Gly Gln Gly Thr Pro Ala Val Asn Phe Thr Asp Tyr Ser Ser Ser 
            20                  25                  30          
Ser Leu Glu Gln Phe Trp Asn Asp Trp Val Gly Glu Val Glu Glu Pro 
        35                  40                  45              
Pro Phe Ala Tyr Val Pro Glu Pro Pro Asn Pro Tyr Pro Leu Pro Asn 
    50                  55                  60                  
Ala Pro Pro Pro Ile Tyr Pro Glu Tyr Tyr Thr Lys Arg Pro Lys Asp 
65                  70                  75                  80  
Ile Leu Pro Asp Tyr Lys Phe Pro Lys Asp Phe Leu Phe Gly Trp Ala 
                85                  90                  95      
Thr Ala Ala Gln Gln Trp Glu Gly Ala Val Lys Ala Asp Gly Lys Gly 
            100                 105                 110         
Pro Ser Ile Trp Asp Trp Ala Ser Arg Phe Pro Gly Phe Ile Ala Asp 
        115                 120                 125             
Asn Thr Thr Ser Asp Val Gly Asp Leu Gly Tyr Tyr Leu Tyr Lys Glu 
    130                 135                 140                 
Asp Leu Ala Arg Ile Ala Ala Leu Gly Ala Asn Val Tyr Ser Phe Ser 
145                 150                 155                 160 
Met Phe Trp Thr Arg Ile Phe Pro Phe Gly Lys Ala Asp Ser Pro Val 
                165                 170                 175     
Asn Gln Ala Gly Ile Asp Phe Tyr His Asp Leu Ile Asp Tyr Ser Trp 
            180                 185                 190         
Ser Leu Gly Ile Glu Pro Val Val Thr Leu Phe His Trp Asp Thr Pro 
        195                 200                 205             
Leu Ala Leu Gln Leu Glu Tyr Gly Gly Phe Ala Ser Glu Arg Ile Ile 
    210                 215                 220                 
Asp Asp Tyr Val Asn Tyr Ala Glu Thr Val Phe Lys Ala Tyr Asn Gly 
225                 230                 235                 240 
Ser Val His Lys Trp Val Thr Phe Asn Glu Pro Val Val Phe Cys Ser 
                245                 250                 255     
Gln Met Ala Ala Pro Val Asn Thr Thr Leu Pro Pro Asn Leu Asn Ser 
            260                 265                 270         
Thr Ile Tyr Pro Tyr Thr Cys Ser Tyr His Leu Val Leu Ala His Ala 
        275                 280                 285             
Lys Thr Val Lys Arg Phe Arg Glu Leu Asn Ile Gln Gly Gln Ile Ala 
    290                 295                 300                 
Phe Lys Ser Asp Asn Phe Val Gly Ile Pro Trp Arg Glu Gly Asn Gln 
305                 310                 315                 320 
Glu Asp Ile Asp Ala Val Glu Arg His Gln Ala Tyr Gln Ile Gly Ile 
                325                 330                 335     
Phe Ala Glu Pro Ile Tyr Asn Thr Gly Asp Trp Pro Asp Ile Val Lys 
            340                 345                 350         
Asn Asp Leu Ser Pro Asp Ile Leu Pro Arg Phe Thr Asp Asp Glu Ile 
        355                 360                 365             
Ala Met Ile Lys Cys Thr Ala Asp Phe Phe Pro Ile Asp Gly Tyr Arg 
    370                 375                 380                 
Asp Gly Tyr Val Gln Ala Val Pro Gly Gly Val Glu Ala Cys Val Ala 
385                 390                 395                 400 
Asn Ile Ser Asn Pro Leu Trp Pro Ala Cys Asn Gln Val Asn Phe Tyr 
                405                 410                 415     
Asp Ser Thr Pro Ala Gly Trp Ala Ile Gly Thr Phe Gly Asn Trp Pro 
            420                 425                 430         
Thr Thr Pro Trp Leu Gln Asn Thr Trp Gln Phe Val Arg Pro Phe Leu 
        435                 440                 445             
Ala Asp Leu Ala Lys Arg Tyr Pro Thr Glu Gly Gly Ile Tyr Leu Ser 
    450                 455                 460                 
Glu Phe Gly Phe Ser Glu Pro Phe Glu Asn Asp Lys Thr Phe Ile Tyr 
465                 470                 475                 480 
Gln Ile Thr Gln Asp Ser Gly Arg Thr Ala Tyr Phe Asn Ser Tyr Leu 
                485                 490                 495     
Gly Glu Val Leu Lys Gly Ile Val Glu Asp Gly Ile Pro Ile Lys Gly 
            500                 505                 510         
Val Phe Gly Trp Ser Met Val Asp Asn Phe Glu Trp Asn Ser Gly Leu 
        515                 520                 525             
Ser Thr Arg Phe Gly Val Gln Tyr Val Asp Tyr Asn Ser Pro Thr Arg 
    530                 535                 540                 
Gln Arg Thr Phe Lys Arg Ser Ala Leu Glu Met Ser Glu Phe Trp Asn 
545                 550                 555                 560 
Ala His Arg Cys Ser Ala 
                565     

<210> 3
<211> 560
<212> PRT
<213> Cryptococcus terrestris


<400> 3
Ala Ile Thr Pro Thr Ala Thr Gly Pro Val Gly Gly Gln Gly Thr Pro 
1               5                   10                  15      
Ala Val Asn Phe Thr Asp Tyr Ser Ser Ser Ser Leu Glu Gln Phe Trp 
            20                  25                  30          
Asn Asp Trp Val Gly Glu Val Glu Glu Pro Pro Phe Ala Tyr Val Pro 
        35                  40                  45              
Glu Pro Pro Asn Pro Tyr Pro Leu Pro Asn Ala Pro Pro Pro Ile Tyr 
    50                  55                  60                  
Pro Glu Tyr Tyr Thr Lys Arg Pro Lys Asp Ile Leu Pro Asp Tyr Lys 
65                  70                  75                  80  
Phe Pro Lys Asp Phe Leu Phe Gly Trp Ala Thr Ala Ala Gln Gln Trp 
                85                  90                  95      
Glu Gly Ala Val Lys Ala Asp Gly Lys Gly Pro Ser Ile Trp Asp Trp 
            100                 105                 110         
Ala Ser Arg Phe Pro Gly Phe Ile Ala Asp Asn Thr Thr Ser Asp Val 
        115                 120                 125             
Gly Asp Leu Gly Tyr Tyr Leu Tyr Lys Glu Asp Leu Ala Arg Ile Ala 
    130                 135                 140                 
Ala Leu Gly Ala Asn Val Tyr Ser Phe Ser Met Phe Trp Thr Arg Ile 
145                 150                 155                 160 
Phe Pro Phe Gly Lys Ala Asp Ser Pro Val Asn Gln Ala Gly Ile Asp 
                165                 170                 175     
Phe Tyr His Asp Leu Ile Asp Tyr Ser Trp Ser Leu Gly Ile Glu Pro 
            180                 185                 190         
Val Val Thr Leu Phe His Trp Asp Thr Pro Leu Ala Leu Gln Leu Glu 
        195                 200                 205             
Tyr Gly Gly Phe Ala Ser Glu Arg Ile Ile Asp Asp Tyr Val Asn Tyr 
    210                 215                 220                 
Ala Glu Thr Val Phe Lys Ala Tyr Asn Gly Ser Val His Lys Trp Val 
225                 230                 235                 240 
Thr Phe Asn Glu Pro Val Val Phe Cys Ser Gln Met Ala Ala Pro Val 
                245                 250                 255     
Asn Thr Thr Leu Pro Pro Asn Leu Asn Ser Thr Ile Tyr Pro Tyr Thr 
            260                 265                 270         
Cys Ser Tyr His Leu Val Leu Ala His Ala Lys Thr Val Lys Arg Phe 
        275                 280                 285             
Arg Glu Leu Asn Ile Gln Gly Gln Ile Ala Phe Lys Ser Asp Asn Phe 
    290                 295                 300                 
Val Gly Ile Pro Trp Arg Glu Gly Asn Gln Glu Asp Ile Asp Ala Val 
305                 310                 315                 320 
Glu Arg His Gln Ala Tyr Gln Ile Gly Ile Phe Ala Glu Pro Ile Tyr 
                325                 330                 335     
Asn Thr Gly Asp Trp Pro Asp Ile Val Lys Asn Asp Leu Ser Pro Asp 
            340                 345                 350         
Ile Leu Pro Arg Phe Thr Asp Asp Glu Ile Ala Met Ile Lys Cys Thr 
        355                 360                 365             
Ala Asp Phe Phe Pro Ile Asp Gly Tyr Arg Asp Gly Tyr Val Gln Ala 
    370                 375                 380                 
Val Pro Gly Gly Val Glu Ala Cys Val Ala Asn Ile Ser Asn Pro Leu 
385                 390                 395                 400 
Trp Pro Ala Cys Asn Gln Val Asn Phe Tyr Asp Ser Thr Pro Ala Gly 
                405                 410                 415     
Trp Ala Ile Gly Thr Phe Gly Asn Trp Pro Thr Thr Pro Trp Leu Gln 
            420                 425                 430         
Asn Thr Trp Gln Phe Val Arg Pro Phe Leu Ala Asp Leu Ala Lys Arg 
        435                 440                 445             
Tyr Pro Thr Glu Gly Gly Ile Tyr Leu Ser Glu Phe Gly Phe Ser Glu 
    450                 455                 460                 
Pro Phe Glu Asn Asp Lys Thr Phe Ile Tyr Gln Ile Thr Gln Asp Ser 
465                 470                 475                 480 
Gly Arg Thr Ala Tyr Phe Asn Ser Tyr Leu Gly Glu Val Leu Lys Gly 
                485                 490                 495     
Ile Val Glu Asp Gly Ile Pro Ile Lys Gly Val Phe Gly Trp Ser Met 
            500                 505                 510         
Val Asp Asn Phe Glu Trp Asn Ser Gly Leu Ser Thr Arg Phe Gly Val 
        515                 520                 525             
Gln Tyr Val Asp Tyr Asn Ser Pro Thr Arg Gln Arg Thr Phe Lys Arg 
    530                 535                 540                 
Ser Ala Leu Glu Met Ser Glu Phe Trp Asn Ala His Arg Cys Ser Ala 
545                 550                 555                 560 



<210> 4
<211> 555
<212> PRT
<213> Cryptococcus terrestris


<400> 4
Ala Thr Gly Pro Val Gly Gly Gln Gly Thr Pro Ala Val Asn Phe Thr 
1               5                   10                  15      
Asp Tyr Ser Ser Ser Ser Leu Glu Gln Phe Trp Asn Asp Trp Val Gly 
            20                  25                  30          
Glu Val Glu Glu Pro Pro Phe Ala Tyr Val Pro Glu Pro Pro Asn Pro 
        35                  40                  45              
Tyr Pro Leu Pro Asn Ala Pro Pro Pro Ile Tyr Pro Glu Tyr Tyr Thr 
    50                  55                  60                  
Lys Arg Pro Lys Asp Ile Leu Pro Asp Tyr Lys Phe Pro Lys Asp Phe 
65                  70                  75                  80  
Leu Phe Gly Trp Ala Thr Ala Ala Gln Gln Trp Glu Gly Ala Val Lys 
                85                  90                  95      
Ala Asp Gly Lys Gly Pro Ser Ile Trp Asp Trp Ala Ser Arg Phe Pro 
            100                 105                 110         
Gly Phe Ile Ala Asp Asn Thr Thr Ser Asp Val Gly Asp Leu Gly Tyr 
        115                 120                 125             
Tyr Leu Tyr Lys Glu Asp Leu Ala Arg Ile Ala Ala Leu Gly Ala Asn 
    130                 135                 140                 
Val Tyr Ser Phe Ser Met Phe Trp Thr Arg Ile Phe Pro Phe Gly Lys 
145                 150                 155                 160 
Ala Asp Ser Pro Val Asn Gln Ala Gly Ile Asp Phe Tyr His Asp Leu 
                165                 170                 175     
Ile Asp Tyr Ser Trp Ser Leu Gly Ile Glu Pro Val Val Thr Leu Phe 
            180                 185                 190         
His Trp Asp Thr Pro Leu Ala Leu Gln Leu Glu Tyr Gly Gly Phe Ala 
        195                 200                 205             
Ser Glu Arg Ile Ile Asp Asp Tyr Val Asn Tyr Ala Glu Thr Val Phe 
    210                 215                 220                 
Lys Ala Tyr Asn Gly Ser Val His Lys Trp Val Thr Phe Asn Glu Pro 
225                 230                 235                 240 
Val Val Phe Cys Ser Gln Met Ala Ala Pro Val Asn Thr Thr Leu Pro 
                245                 250                 255     
Pro Asn Leu Asn Ser Thr Ile Tyr Pro Tyr Thr Cys Ser Tyr His Leu 
            260                 265                 270         
Val Leu Ala His Ala Lys Thr Val Lys Arg Phe Arg Glu Leu Asn Ile 
        275                 280                 285             
Gln Gly Gln Ile Ala Phe Lys Ser Asp Asn Phe Val Gly Ile Pro Trp 
    290                 295                 300                 
Arg Glu Gly Asn Gln Glu Asp Ile Asp Ala Val Glu Arg His Gln Ala 
305                 310                 315                 320 
Tyr Gln Ile Gly Ile Phe Ala Glu Pro Ile Tyr Asn Thr Gly Asp Trp 
                325                 330                 335     
Pro Asp Ile Val Lys Asn Asp Leu Ser Pro Asp Ile Leu Pro Arg Phe 
            340                 345                 350         
Thr Asp Asp Glu Ile Ala Met Ile Lys Cys Thr Ala Asp Phe Phe Pro 
        355                 360                 365             
Ile Asp Gly Tyr Arg Asp Gly Tyr Val Gln Ala Val Pro Gly Gly Val 
    370                 375                 380                 
Glu Ala Cys Val Ala Asn Ile Ser Asn Pro Leu Trp Pro Ala Cys Asn 
385                 390                 395                 400 
Gln Val Asn Phe Tyr Asp Ser Thr Pro Ala Gly Trp Ala Ile Gly Thr 
                405                 410                 415     
Phe Gly Asn Trp Pro Thr Thr Pro Trp Leu Gln Asn Thr Trp Gln Phe 
            420                 425                 430         
Val Arg Pro Phe Leu Ala Asp Leu Ala Lys Arg Tyr Pro Thr Glu Gly 
        435                 440                 445             
Gly Ile Tyr Leu Ser Glu Phe Gly Phe Ser Glu Pro Phe Glu Asn Asp 
    450                 455                 460                 
Lys Thr Phe Ile Tyr Gln Ile Thr Gln Asp Ser Gly Arg Thr Ala Tyr 
465                 470                 475                 480 
Phe Asn Ser Tyr Leu Gly Glu Val Leu Lys Gly Ile Val Glu Asp Gly 
                485                 490                 495     
Ile Pro Ile Lys Gly Val Phe Gly Trp Ser Met Val Asp Asn Phe Glu 
            500                 505                 510         
Trp Asn Ser Gly Leu Ser Thr Arg Phe Gly Val Gln Tyr Val Asp Tyr 
        515                 520                 525             
Asn Ser Pro Thr Arg Gln Arg Thr Phe Lys Arg Ser Ala Leu Glu Met 
    530                 535                 540                 
Ser Glu Phe Trp Asn Ala His Arg Cys Ser Ala 
545                 550                 555 

<210> 5
<211> 2091
<212> DNA
<213> Cryptococcus terrestris


<400> 5
atgatcccgg caagtgcact ccttgccgcc gtacccctcc ttgcccaaca ggtgagcgcc      60

ggcatactgc gaagacagaa tgctgcgggt tcggattcgg cagcgcctga ctcgatcgcg     120

gatgcgtcca ccggtgtcgt ctcgtcgatc gccacggaag ccgtctcttc gggagcgaca     180

ggccttgtcg cgtccgtcgc catgtcattc gcctcgtcga tggcgactcc aacggccaca     240

gtgacgggcc taagctccga gacgggagcg ccttccaaca ccccaatggc cagtgcctct     300

ggtagtgtcc ctacaaccac ctctgccgtc gggtctggcg acttcgactg ggtccagaca     360

gacggcctgc ccacgatcac gaccactttg gctactacga accaggacgc aatcactccg     420

acggcgacgg gccccgtcgg cggacagggc acccctgctg tcaacttcac cgactactct     480

tcatcgtcgc tcgagcagtt ttggaacgac tgggtgggag aggtggagga gccgccgttc     540

gcctacgtcc cggaaccgcc taacccgtac ccgttaccga acgccccgcc tccaatctac     600

cccgagtact acaccaagcg tcccaaggac attctccccg actacaagtt ccccaaagac     660

ttcctgtttg gctgggcgac cgccgcgcag cagtgggagg gggccgtcaa ggcggatggg     720

aaggggccgt ccatctggga ctgggccagc cggttcccgg ggttcattgc ggacaacacg     780

acttccgacg tcggagactt gggatactat ttatacaaag aggacctcgc taggatcgct     840

gcattgggcg caaacgttta ctctttcagc atgttctgga cacggatctt tcccttcggc     900

aaggccgact cgcctgtcaa tcaagcgggc atcgacttct accacgactt gatcgattat     960

tcttggagcc tgggcatcga gcccgtcgtg acattgttcc attgggatac gccgctcgcc    1020

ctccagcttg agtacggagg tttcgccagc gagcgaatca ttgatgacta cgtcaactat    1080

gcggaaaccg tgttcaaggc gtacaacggt agtgtgcaca aatgggtcac attcaacgag    1140

cctgtggtgt tctgcagcca gatggcagcg cccgtgaaca ctactctacc gccgaacctc    1200

aactcgacaa tctaccccta tacctgcagc tatcacctcg tgctagccca cgccaagacg    1260

gtcaagcggt tcagggagtt gaacattcag ggccagatcg ctttcaagtc ggacaatttt    1320

gtcggtatcc cgtggcgtga ggggaaccaa gaggacatag atgcggtcga gcgccatcag    1380

gcgtaccaga tcgggatctt tgctgagccg atctacaaca ccggagactg gcccgatatc    1440

gtgaagaatg atctctcccc cgacatcctt cctcgattca cggatgacga gatcgcgatg    1500

atcaagtgca ctgccgactt cttccccatc gatggctaca gggacggtta tgtccaggct    1560

gtaccggggg gtgtcgaagc ttgcgtcgcg aacatcagca acccgctttg gcctgcttgc    1620

aaccaagtca acttctatga ttccacaccc gccggatggg cgatcggcac gttcggcaac    1680

tggccgacga caccctggct ccagaacacc tggcagtttg tgcgcccctt cctcgctgat    1740

ctggcaaagc ggtaccccac cgaaggcggc atctaccttt cggaatttgg cttctccgag    1800

ccgttcgaaa atgataaaac cttcatttac cagatcaccc aggacagcgg acggacggcg    1860

tacttcaaca gttacctcgg cgaagtgttg aaaggtatcg ttgaagatgg cattcctatc    1920

aagggcgtgt tcggctggag tatggtcgac aactttgaat ggaactctgg cttgtctact    1980

cgcttcggcg tccaatacgt tgattacaac agcccgacgc gtcaacgaac gttcaagcgg    2040

tccgctctgg agatgagcga gttctggaat gctcatcgat gttccgccta a             2091


<210> 6
<211> 1701
<212> DNA
<213> Cryptococcus terrestris


<400> 6
gctactacga accaggacgc aatcactccg acggcgacgg gccccgtcgg cggacagggc      60

acccctgctg tcaacttcac cgactactct tcatcgtcgc tcgagcagtt ttggaacgac     120

tgggtgggag aggtggagga gccgccgttc gcctacgtcc cggaaccgcc taacccgtac     180

ccgttaccga acgccccgcc tccaatctac cccgagtact acaccaagcg tcccaaggac     240

attctccccg actacaagtt ccccaaagac ttcctgtttg gctgggcgac cgccgcgcag     300

cagtgggagg gggccgtcaa ggcggatggg aaggggccgt ccatctggga ctgggccagc     360

cggttcccgg ggttcattgc ggacaacacg acttccgacg tcggagactt gggatactat     420

ttatacaaag aggacctcgc taggatcgct gcattgggcg caaacgttta ctctttcagc     480

atgttctgga cacggatctt tcccttcggc aaggccgact cgcctgtcaa tcaagcgggc     540

atcgacttct accacgactt gatcgattat tcttggagcc tgggcatcga gcccgtcgtg     600

acattgttcc attgggatac gccgctcgcc ctccagcttg agtacggagg tttcgccagc     660

gagcgaatca ttgatgacta cgtcaactat gcggaaaccg tgttcaaggc gtacaacggt     720

agtgtgcaca aatgggtcac attcaacgag cctgtggtgt tctgcagcca gatggcagcg     780

cccgtgaaca ctactctacc gccgaacctc aactcgacaa tctaccccta tacctgcagc     840

tatcacctcg tgctagccca cgccaagacg gtcaagcggt tcagggagtt gaacattcag     900

ggccagatcg ctttcaagtc ggacaatttt gtcggtatcc cgtggcgtga ggggaaccaa     960

gaggacatag atgcggtcga gcgccatcag gcgtaccaga tcgggatctt tgctgagccg    1020

atctacaaca ccggagactg gcccgatatc gtgaagaatg atctctcccc cgacatcctt    1080

cctcgattca cggatgacga gatcgcgatg atcaagtgca ctgccgactt cttccccatc    1140

gatggctaca gggacggtta tgtccaggct gtaccggggg gtgtcgaagc ttgcgtcgcg    1200

aacatcagca acccgctttg gcctgcttgc aaccaagtca acttctatga ttccacaccc    1260

gccggatggg cgatcggcac gttcggcaac tggccgacga caccctggct ccagaacacc    1320

tggcagtttg tgcgcccctt cctcgctgat ctggcaaagc ggtaccccac cgaaggcggc    1380

atctaccttt cggaatttgg cttctccgag ccgttcgaaa atgataaaac cttcatttac    1440

cagatcaccc aggacagcgg acggacggcg tacttcaaca gttacctcgg cgaagtgttg    1500

aaaggtatcg ttgaagatgg cattcctatc aagggcgtgt tcggctggag tatggtcgac    1560

aactttgaat ggaactctgg cttgtctact cgcttcggcg tccaatacgt tgattacaac    1620

agcccgacgc gtcaacgaac gttcaagcgg tccgctctgg agatgagcga gttctggaat    1680

gctcatcgat gttccgccta a                                              1701


<210> 7
<211> 1683
<212> DNA
<213> Cryptococcus terrestris


<400> 7
gcaatcactc cgacggcgac gggccccgtc ggcggacagg gcacccctgc tgtcaacttc      60

accgactact cttcatcgtc gctcgagcag ttttggaacg actgggtggg agaggtggag     120

gagccgccgt tcgcctacgt cccggaaccg cctaacccgt acccgttacc gaacgccccg     180

cctccaatct accccgagta ctacaccaag cgtcccaagg acattctccc cgactacaag     240

ttccccaaag acttcctgtt tggctgggcg accgccgcgc agcagtggga gggggccgtc     300

aaggcggatg ggaaggggcc gtccatctgg gactgggcca gccggttccc ggggttcatt     360

gcggacaaca cgacttccga cgtcggagac ttgggatact atttatacaa agaggacctc     420

gctaggatcg ctgcattggg cgcaaacgtt tactctttca gcatgttctg gacacggatc     480

tttcccttcg gcaaggccga ctcgcctgtc aatcaagcgg gcatcgactt ctaccacgac     540

ttgatcgatt attcttggag cctgggcatc gagcccgtcg tgacattgtt ccattgggat     600

acgccgctcg ccctccagct tgagtacgga ggtttcgcca gcgagcgaat cattgatgac     660

tacgtcaact atgcggaaac cgtgttcaag gcgtacaacg gtagtgtgca caaatgggtc     720

acattcaacg agcctgtggt gttctgcagc cagatggcag cgcccgtgaa cactactcta     780

ccgccgaacc tcaactcgac aatctacccc tatacctgca gctatcacct cgtgctagcc     840

cacgccaaga cggtcaagcg gttcagggag ttgaacattc agggccagat cgctttcaag     900

tcggacaatt ttgtcggtat cccgtggcgt gaggggaacc aagaggacat agatgcggtc     960

gagcgccatc aggcgtacca gatcgggatc tttgctgagc cgatctacaa caccggagac    1020

tggcccgata tcgtgaagaa tgatctctcc cccgacatcc ttcctcgatt cacggatgac    1080

gagatcgcga tgatcaagtg cactgccgac ttcttcccca tcgatggcta cagggacggt    1140

tatgtccagg ctgtaccggg gggtgtcgaa gcttgcgtcg cgaacatcag caacccgctt    1200

tggcctgctt gcaaccaagt caacttctat gattccacac ccgccggatg ggcgatcggc    1260

acgttcggca actggccgac gacaccctgg ctccagaaca cctggcagtt tgtgcgcccc    1320

ttcctcgctg atctggcaaa gcggtacccc accgaaggcg gcatctacct ttcggaattt    1380

ggcttctccg agccgttcga aaatgataaa accttcattt accagatcac ccaggacagc    1440

ggacggacgg cgtacttcaa cagttacctc ggcgaagtgt tgaaaggtat cgttgaagat    1500

ggcattccta tcaagggcgt gttcggctgg agtatggtcg acaactttga atggaactct    1560

ggcttgtcta ctcgcttcgg cgtccaatac gttgattaca acagcccgac gcgtcaacga    1620

acgttcaagc ggtccgctct ggagatgagc gagttctgga atgctcatcg atgttccgcc    1680

taa                                                                  1683


<210> 8
<211> 1668
<212> DNA
<213> Cryptococcus terrestris


<400> 8
gcgacgggcc ccgtcggcgg acagggcacc cctgctgtca acttcaccga ctactcttca      60

tcgtcgctcg agcagttttg gaacgactgg gtgggagagg tggaggagcc gccgttcgcc     120

tacgtcccgg aaccgcctaa cccgtacccg ttaccgaacg ccccgcctcc aatctacccc     180

gagtactaca ccaagcgtcc caaggacatt ctccccgact acaagttccc caaagacttc     240

ctgtttggct gggcgaccgc cgcgcagcag tgggaggggg ccgtcaaggc ggatgggaag     300

gggccgtcca tctgggactg ggccagccgg ttcccggggt tcattgcgga caacacgact     360

tccgacgtcg gagacttggg atactattta tacaaagagg acctcgctag gatcgctgca     420

ttgggcgcaa acgtttactc tttcagcatg ttctggacac ggatctttcc cttcggcaag     480

gccgactcgc ctgtcaatca agcgggcatc gacttctacc acgacttgat cgattattct     540

tggagcctgg gcatcgagcc cgtcgtgaca ttgttccatt gggatacgcc gctcgccctc     600

cagcttgagt acggaggttt cgccagcgag cgaatcattg atgactacgt caactatgcg     660

gaaaccgtgt tcaaggcgta caacggtagt gtgcacaaat gggtcacatt caacgagcct     720

gtggtgttct gcagccagat ggcagcgccc gtgaacacta ctctaccgcc gaacctcaac     780

tcgacaatct acccctatac ctgcagctat cacctcgtgc tagcccacgc caagacggtc     840

aagcggttca gggagttgaa cattcagggc cagatcgctt tcaagtcgga caattttgtc     900

ggtatcccgt ggcgtgaggg gaaccaagag gacatagatg cggtcgagcg ccatcaggcg     960

taccagatcg ggatctttgc tgagccgatc tacaacaccg gagactggcc cgatatcgtg    1020

aagaatgatc tctcccccga catccttcct cgattcacgg atgacgagat cgcgatgatc    1080

aagtgcactg ccgacttctt ccccatcgat ggctacaggg acggttatgt ccaggctgta    1140

ccggggggtg tcgaagcttg cgtcgcgaac atcagcaacc cgctttggcc tgcttgcaac    1200

caagtcaact tctatgattc cacacccgcc ggatgggcga tcggcacgtt cggcaactgg    1260

ccgacgacac cctggctcca gaacacctgg cagtttgtgc gccccttcct cgctgatctg    1320

gcaaagcggt accccaccga aggcggcatc tacctttcgg aatttggctt ctccgagccg    1380

ttcgaaaatg ataaaacctt catttaccag atcacccagg acagcggacg gacggcgtac    1440

ttcaacagtt acctcggcga agtgttgaaa ggtatcgttg aagatggcat tcctatcaag    1500

ggcgtgttcg gctggagtat ggtcgacaac tttgaatgga actctggctt gtctactcgc    1560

ttcggcgtcc aatacgttga ttacaacagc ccgacgcgtc aacgaacgtt caagcggtcc    1620

gctctggaga tgagcgagtt ctggaatgct catcgatgtt ccgcctaa                 1668


<210> 9
<211> 11
<212> PRT
<213> Cryptococcus terrestris


<400> 9
Gly Val Gln Tyr Val Asp Tyr Asn Ser Pro Thr 
1               5                   10      

<210> 10
<211> 11
<212> PRT
<213> Cryptococcus terrestris


<400> 10
Phe Leu Phe Gly Trp Ala Thr Ala Ala Gln Gln 
1               5                   10      

<210> 11
<211> 15
<212> PRT
<213> Cryptococcus terrestris


<400> 11
Gln Ala Tyr Gln Ile Gly Ile Phe Ala Glu Pro Ile Tyr Asn Thr 
1               5                   10                  15  

<210> 12
<211> 8
<212> PRT
<213> Cryptococcus terrestris


<400> 12
Pro Ser Ile Trp Asp Trp Ala Ser 
1               5               

<210> 13
<211> 10
<212> PRT
<213> Cryptococcus terrestris


<400> 13
Glu Glu Pro Pro Phe Ala Tyr Val Pro Glu 
1               5                   10  

<210> 14
<211> 41
<212> DNA
<213> Artificial Sequence


<220> 
<223> 5'RACE GSP primer

<400> 14
gattacgcca agcttgcaaa gatcccgatc tggtacgcct g                         41


<210> 15
<211> 39
<212> DNA
<213> Artificial Sequence


<220> 
<223> 3'RACE GSP primer

<400> 15
gattacgcca agcttttcct gtttggctgg gcgaccgcc                            39


<210> 16
<211> 2942
<212> DNA
<213> Cryptococcus terrestris


<400> 16
atgatcccgg caagtgcact ccttgccgcc gtacccctcc ttgcccaaca ggtgagcgcc      60

ggcatactgc gaagacagaa tgctgcgggt tcggattcgg cagcgcctga ctcgatcgcg     120

gatgcgtcca ccggtgtcgt ctcgtcgatc gccacggaag ccgtctcttc gggagcgaca     180

ggccttgtcg cgtccgtcgc catgtcattc gcctcgtcga tggcgactcc aacggccaca     240

gtgacgggcc taagctccga gacgggagcg ccttccaaca ccccaatggc cagtgcctct     300

ggtagtgtcc ctacaaccac ctctgccgtc gggtctggcg acttcgactg ggtccagaca     360

gacggcctgc ccacgatcac gaccactttg gctactacga accaggacgc aatcactccg     420

acggcgacgg gccccgtcgg cggacagggc acccctgctg tcaacttcac cgactactct     480

tcatcgtcgc tcgagcagtt ttggaacgac tgggtaagtt aggccacggc tccatctgct     540

gacgagggtc caggagagct gacgcacagg tgggagaggt ggaggagccg ccgttcgcct     600

acgtcccgga accgcctaac ccgtacccgt taccgaacgc cccgcctcca atctaccccg     660

agtactacac caagcgtccc aaggacattc tccccgacta caagttcccc aaagacttcc     720

tgtttggctg ggcgaccgcc gcgcagcagt gggagggggc cgtcaaggcg gatgggaagg     780

ggccgtccat ctgggactgg gccagccggt tcccggggtt cattgcggac aacacgactt     840

ccggtgagct gagaatgacc acctttcagt acgagagctc acttcagacg tcggagactt     900

gggatactat ttatacaaag agggttagcc ggggccgtat gagccagtgc tggatgctga     960

gtgcagacct cgctaggatc gctgcattgg gcgcaaacgt ttactctttc agcatgttct    1020

ggacacggat ctttcccttc ggcaaggccg actcgcctgt caatcaagcg ggcatcgact    1080

tctaccacga cttgatcgat tattcttgga gcctgggcat cgagcccgtc gtgtaagcct    1140

gtacaggggc ccatcttgaa ccccgctcat tacaggacat tgttccattg ggatacgccg    1200

ctcgccctcc agcttgagta cggaggtttc gccagcgagc gaatcattga tgactacgtc    1260

aactatgcgg tgagcagtac ggtcccttga gcacagcttg ggctgactcg taaggaaacc    1320

gtgttcaagg cgtacaacgg tagtgtgcac aaatgggtca cattcaacga gcctgtggtg    1380

ttctgcagcc aggtgagcaa ccaaagcgca tgttgagctg atcgaccaga tggcagcgcc    1440

cgtgaacgta agatgagcaa cgagccagac cagtgtcaat gctgaccatg accgtagact    1500

actctaccgc cgaacctcaa ctcgacaatc tacccctata cctgcagcta tcacctcgtg    1560

ctagcccacg ccaagacggt caagcggttc agggagttga acattcgtga gctgatcggt    1620

accgcgtttc tggctgaaga cacgctgact gtcacagagg gccagatcgc tttcaagtcg    1680

gacaattttg tgtgagcatc gctgttgtgg ggagtcgtgc gtgctgaacc tttagcggta    1740

tcccgtggcg tgaggggaac caagaggaca tagatgcggt cgagcgccat caggtgaagt    1800

ctcgccagac cgcggaggct ccgaggctga ccggacaggc gtaccagatc gggatctttg    1860

ctgagccgat ctacaacacc ggagtgaggc ttccctccct cttccgcacg gtacacttgt    1920

ggcttatcga caggactggc ccgatatcgt gaagaatgat ctctcccccg acatccttcc    1980

tcgattcacg gatgacgaga tcgcgatgat caagtgcact gccgacttct tccccatcga    2040

tgtgagcctc caaacccacc cgtcgggaga cgggtcccga gtactacgcc taacgcacag    2100

ggctacaggg acggttatgt ccaggctgta ccggggggtg tcgaagcttg cgtcgcgaac    2160

atcagcaacc cgctttggcc tgcttgcaac caagtcaagt gagactcgtc cagaccccgc    2220

ctgtattgcg agcgccggca ctgacatgca gcttctgtac ggcccacagc accccgtcgc    2280

cgccgctgag ctgatgcata gatgattcca cacccgccgg atgggcgatc ggcacgttcg    2340

gcaactggcc gacgacaccc tggctccaga acacctggca gtttgtgcgc cccttcctcg    2400

ctgatctggc aaagcggtac cccaccgaag gcggcatcta cctttcggaa tttggcttct    2460

ccgagccgtt cgaaaatgag tacgcctatc aactggctgc tgcaaggcat ggcgtactga    2520

gactcagtaa aaccttcatt taccagatca cccaggacag cggacggacg gcgtacttca    2580

acagttacct cggcgaagtg ttgaaaggta tcgttgaaga tggcattcct atcaagggcg    2640

tgttcggctg gagtatggtc gacaactttg aatggaactc tggcttgtct agtacgtcca    2700

cacggccgtg gatccttcga cgcccggtct gacccgtagc tcgcttcggc gtccaatacg    2760

ttgattacaa caggtgagct gtcgtttttg ttttagggat cgcgatgctg atgcaaacag    2820

cccgacgcgt caacgaacgg tacgccgttc atgacctccc cctcgtccct gctgacgtcc    2880

agttcaagcg gtccgctctg gagatgagcg agttctggaa tgctcatcga tgttccgcct    2940

aa                                                                   2942


