                         SEQUENCE LISTING

<110>  ZYMEWORKS INC.
 
<120>  STABILIZED CHIMERIC FABS

<130>  V812789WO

<140>  NOT YET ASSIGNED
<141>  2018-06-29

<150>  62/527,561
<151>  2017-06-30

<160>  32    

<170>  PatentIn version 3.5

<210>  1
<211>  226
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H3 heavy chain Fab

<400>  1

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Asn Ile Asn Arg Asp Gly Ser Ala Ser Tyr Tyr Val Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Arg Gly Val Gly Tyr Phe Asp Leu Trp Gly Arg Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
        115                 120                 125             


Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly 
    130                 135                 140                 


Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
145                 150                 155                 160 


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
                165                 170                 175     


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
            180                 185                 190         


Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser 
        195                 200                 205             


Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr 
    210                 215                 220                 


His Thr 
225     


<210>  2
<211>  217
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H3 light chain (lambda)

<400>  2

Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr 
            20                  25                  30          


Asn Phe Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Asp Val Ser Asp Arg Pro Ser Gly Val Ser Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Ile Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Asp Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Gly Ser Ser 
                85                  90                  95      


Ser Thr His Val Ile Phe Gly Gly Gly Thr Lys Val Thr Val Leu Gly 
            100                 105                 110         


Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu 
        115                 120                 125             


Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe 
    130                 135                 140                 


Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val 
145                 150                 155                 160 


Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys 
                165                 170                 175     


Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser 
            180                 185                 190         


His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu 
        195                 200                 205             


Lys Thr Val Ala Pro Thr Glu Cys Ser 
    210                 215         


<210>  3
<211>  218
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H3 V(lambda)-C(kappa) chimeric light chain

<400>  3

Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr 
            20                  25                  30          


Asn Phe Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Asp Val Ser Asp Arg Pro Ser Gly Val Ser Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Ile Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Asp Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Gly Ser Ser 
                85                  90                  95      


Ser Thr His Val Ile Phe Gly Gly Gly Thr Lys Val Thr Val Leu Arg 
            100                 105                 110         


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
        115                 120                 125             


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
    130                 135                 140                 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
145                 150                 155                 160 


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
                165                 170                 175     


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
            180                 185                 190         


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
        195                 200                 205             


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215             


<210>  4
<211>  240
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EP6b_B01 heavy chain Fab

<400>  4

Gln Leu Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Ala Ser Ile Ser Ala Asn 
            20                  25                  30          


Ser Tyr Tyr Gly Val Trp Val Arg Gln Ser Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Val Gly Ser Ile Ala Tyr Arg Gly Asn Ser Asn Ser Gly Ser Thr 
    50                  55                  60                  


Tyr Tyr Asn Pro Ser Leu Lys Ser Arg Ala Thr Val Ser Val Asp Ser 
65                  70                  75                  80  


Ser Lys Asn Gln Val Ser Leu Arg Leu Thr Ser Val Thr Ala Ala Asp 
                85                  90                  95      


Thr Ala Leu Tyr Tyr Cys Ala Arg Arg Gln Leu Leu Asp Asp Gly Thr 
            100                 105                 110         


Gly Tyr Gln Trp Ala Ala Phe Asp Val Trp Gly Gln Gly Thr Met Val 
        115                 120                 125             


Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
    130                 135                 140                 


Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu 
145                 150                 155                 160 


Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
                165                 170                 175     


Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 
            180                 185                 190         


Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu 
        195                 200                 205             


Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr 
    210                 215                 220                 


Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr 
225                 230                 235                 240 


<210>  5
<211>  216
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EP6b_B01 light chain (lambda)

<400>  5

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Glu Ala Pro Arg Gln 
1               5                   10                  15      


Thr Val Thr Ile Ser Cys Ser Gly Asn Ser Ser Asn Ile Gly Arg Tyr 
            20                  25                  30          


Pro Val Asn Trp Tyr Gln Gln Leu Pro Gly Lys Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Ser Asp Asn Leu Arg Phe Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Thr Ala Ser Leu Ala Ile Arg Asp Leu Leu 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Thr Trp Asp Asp Thr Leu 
                85                  90                  95      


Glu Gly Trp Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu Gly Gln 
            100                 105                 110         


Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu 
        115                 120                 125             


Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr 
    130                 135                 140                 


Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys 
145                 150                 155                 160 


Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr 
                165                 170                 175     


Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His 
            180                 185                 190         


Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys 
        195                 200                 205             


Thr Val Ala Pro Thr Glu Cys Ser 
    210                 215     


<210>  6
<211>  217
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EP6b_B01 V(lambda)-C(kappa) chimeric light chain

<400>  6

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Glu Ala Pro Arg Gln 
1               5                   10                  15      


Thr Val Thr Ile Ser Cys Ser Gly Asn Ser Ser Asn Ile Gly Arg Tyr 
            20                  25                  30          


Pro Val Asn Trp Tyr Gln Gln Leu Pro Gly Lys Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Ser Asp Asn Leu Arg Phe Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Thr Ala Ser Leu Ala Ile Arg Asp Leu Leu 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Thr Trp Asp Asp Thr Leu 
                85                  90                  95      


Glu Gly Trp Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu Arg Thr 
            100                 105                 110         


Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu 
        115                 120                 125             


Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro 
    130                 135                 140                 


Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly 
145                 150                 155                 160 


Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr 
                165                 170                 175     


Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His 
            180                 185                 190         


Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val 
        195                 200                 205             


Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215         


<210>  7
<211>  226
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CAT-2200 heavy chain Fab

<400>  7

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Leu Ile His Gly Val Thr Arg Asn Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
        115                 120                 125             


Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly 
    130                 135                 140                 


Cys Leu Val Lys Asp Tyr Phe Pro Gln Pro Val Thr Val Ser Trp Asn 
145                 150                 155                 160 


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
                165                 170                 175     


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
            180                 185                 190         


Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser 
        195                 200                 205             


Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr 
    210                 215                 220                 


His Thr 
225     


<210>  8
<211>  216
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CAT-2200 light chain (lambda)

<400>  8

Asn Phe Met Leu Thr Gln Pro His Ser Val Ser Glu Ser Pro Gly Lys 
1               5                   10                  15      


Thr Val Thr Ile Ser Cys Thr Arg Ser Ser Gly Ser Leu Ala Asn Tyr 
            20                  25                  30          


Tyr Val Gln Trp Tyr Gln Gln Arg Pro Gly Ser Ser Pro Thr Ile Val 
        35                  40                  45              


Ile Phe Ala Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Ile Asp Ser Ser Ser Asn Ser Ala Ser Leu Thr Ile Ser Gly 
65                  70                  75                  80  


Leu Lys Thr Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Thr Tyr Asp Pro 
                85                  90                  95      


Tyr Ser Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln 
            100                 105                 110         


Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu 
        115                 120                 125             


Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr 
    130                 135                 140                 


Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys 
145                 150                 155                 160 


Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr 
                165                 170                 175     


Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His 
            180                 185                 190         


Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys 
        195                 200                 205             


Thr Val Ala Pro Thr Glu Cys Ser 
    210                 215     


<210>  9
<211>  217
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CAT-2200 V(lambda)-C(kappa) chimeric light chain

<400>  9

Asn Phe Met Leu Thr Gln Pro His Ser Val Ser Glu Ser Pro Gly Lys 
1               5                   10                  15      


Thr Val Thr Ile Ser Cys Thr Arg Ser Ser Gly Ser Leu Ala Asn Tyr 
            20                  25                  30          


Tyr Val Gln Trp Tyr Gln Gln Arg Pro Gly Ser Ser Pro Thr Ile Val 
        35                  40                  45              


Ile Phe Ala Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Ile Asp Ser Ser Ser Asn Ser Ala Ser Leu Thr Ile Ser Gly 
65                  70                  75                  80  


Leu Lys Thr Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Thr Tyr Asp Pro 
                85                  90                  95      


Tyr Ser Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Arg Thr 
            100                 105                 110         


Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu 
        115                 120                 125             


Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro 
    130                 135                 140                 


Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly 
145                 150                 155                 160 


Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr 
                165                 170                 175     


Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His 
            180                 185                 190         


Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val 
        195                 200                 205             


Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215         


<210>  10
<211>  227
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Pertuzumab heavy chain Fab

<400>  10

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Thr Asp Tyr 
            20                  25                  30          


Thr Met Asp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Asp Val Asn Pro Asn Ser Gly Gly Ser Ile Tyr Asn Gln Arg Phe 
    50                  55                  60                  


Lys Gly Arg Phe Thr Leu Ser Val Asp Arg Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asn Leu Gly Pro Ser Phe Tyr Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
        115                 120                 125             


Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu 
    130                 135                 140                 


Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
145                 150                 155                 160 


Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
                165                 170                 175     


Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
            180                 185                 190         


Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro 
        195                 200                 205             


Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys 
    210                 215                 220                 


Thr His Thr 
225         


<210>  11
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Pertuzumab light chain (kappa)

<400>  11

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Val Ser Ile Gly 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Tyr Arg Tyr Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Tyr Ile Tyr Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  12
<211>  225
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  D3H44 heavy chain Fab

<400>  12

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile Lys Glu Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Leu Ile Asp Pro Glu Gln Gly Asn Thr Ile Tyr Asp Pro Lys Phe 
    50                  55                  60                  


Gln Asp Arg Ala Thr Ile Ser Ala Asp Asn Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Thr Ala Ala Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
        115                 120                 125             


Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys 
    130                 135                 140                 


Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
145                 150                 155                 160 


Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
                165                 170                 175     


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
            180                 185                 190         


Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn 
        195                 200                 205             


Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His 
    210                 215                 220                 


Thr 
225 


<210>  13
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  D3H44 light chain (kappa)

<400>  13

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Arg Asp Ile Lys Ser Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Val Leu Ile 
        35                  40                  45              


Tyr Tyr Ala Thr Ser Leu Ala Glu Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln His Gly Glu Ser Pro Trp 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  14
<211>  227
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG1 Fc

<400>  14

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
1               5                   10                  15      


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            20                  25                  30          


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
65                  70                  75                  80  


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        115                 120                 125             


Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
    130                 135                 140                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                165                 170                 175     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        195                 200                 205             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Pro Gly Lys 
225         


<210>  15
<211>  681
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IgG1 Fc

<400>  15
gataagaccc acacctgccc tccctgtcca gctccagaac tgctgggagg acctagcgtg       60

ttcctgtttc cccctaagcc aaaagacact ctgatgattt ccaggactcc cgaggtgacc      120

tgcgtggtgg tggacgtgtc tcacgaggac cccgaagtga agttcaactg gtacgtggat      180

ggcgtggaag tgcataatgc taagacaaaa ccaagagagg aacagtacaa ctccacttat      240

cgcgtcgtga gcgtgctgac cgtgctgcac caggactggc tgaacgggaa ggagtataag      300

tgcaaagtca gtaataaggc cctgcctgct ccaatcgaaa aaaccatctc taaggccaaa      360

ggccagccaa gggagcccca ggtgtacaca ctgccaccca gcagagacga actgaccaag      420

aaccaggtgt ccctgacatg tctggtgaaa ggcttctatc ctagtgatat tgctgtggag      480

tgggaatcaa atggacagcc agagaacaat tacaagacca cacctccagt gctggacagc      540

gatggcagct tcttcctgta ttccaagctg acagtggata aatctcgatg gcagcagggg      600

aacgtgttta gttgttcagt gatgcatgaa gccctgcaca atcattacac tcagaagagc      660

ctgtccctgt ctcccggcaa a                                                681


<210>  16
<211>  678
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  H3 heavy chain Fab

<400>  16
caggtccagc tgcaggaatc tggcggagga ctggtcaaac ctggaggctc tctgagactg       60

tcatgtgctg ctagtggctt tactttcagc tcctactgga tgtcttgggt gcgacaggcc      120

cccggcaagg gactggagtg ggtcgcaaac atcaatagag acggatctgc cagttactat      180

gtggatagcg tcaagggccg gttcaccatt tcaagagacg atgctaaaaa cagcctgtat      240

ctgcagatga acagcctgag ggccgaagac acagctgtgt actattgcgc acgcgatcgc      300

ggcgtgggat atttcgatct gtggggccgc ggaaccctgg tgaccgtctc atctgctagc      360

actaaggggc cttccgtgtt tccactggct ccctctagta aatccacctc tggaggcaca      420

gctgcactgg gatgtctggt gaaggattac ttccctgaac cagtcacagt gagttggaac      480

tcaggggctc tgacaagtgg agtccatact tttcccgcag tgctgcagtc aagcggactg      540

tactccctgt cctctgtggt caccgtgcct agttcaagcc tgggcaccca gacatatatc      600

tgcaacgtga atcacaagcc atcaaataca aaagtcgaca agaaggtgga accaaaaagc      660

tgcgataaaa cccataca                                                    678


<210>  17
<211>  651
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  H3 light chain (lambda)

<400>  17
cagagcgcac tgactcagcc tgcttccgtg tccggctccc ctgggcagag tattacaatc       60

tcatgcactg gcacctcatc cgacgtgggc gggtacaact ttgtcagctg gtatcagcag      120

cacccaggca aggcccccaa actgatgatc tacgacgtgt ccgatcggcc ttccggggtc      180

tctgacagat tctccggatc taagagtggc aataccgcca gcctgatcat ttccgggctg      240

caggcagacg atgaggccga ttactattgc agctcctatg gatctagttc aacacatgtg      300

atcttcggag gcgggaccaa ggtgacagtc ctggggcagc ctaaagcggc gccctctgtg      360

actctgtttc cccctagctc cgaggaactg caggctaaca aggcaactct ggtgtgtctg      420

attagcgact tctacccagg agctgtgacc gtcgcctgga aggctgattc tagtcccgtg      480

aaagcaggcg tcgagaccac aactcctagt aagcagtcaa acaacaagta cgcagcctca      540

agctatctgt ctctgacacc cgaacagtgg aaaagtcaca ggtcatatag ctgccaggtg      600

actcacgagg gctcaactgt ggagaaaacc gtcgcaccaa ccgaatgttc c               651


<210>  18
<211>  654
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  H3 V(lambda)-C(kappa) chimeric light chain

<400>  18
cagagcgcac tgactcagcc tgcatccgtg tccgggtccc ctgggcagag cattactatt       60

tcatgtactg gaacttcttc agacgtgggc gggtacaact tcgtgtcctg gtatcagcag      120

caccccggca aggcacctaa actgatgatc tacgacgtga gcgatcgacc aagcggggtc      180

tccgacagat tttctggaag taaatcaggc aataccgcct ctctgatcat tagtgggctg      240

caggccgacg atgaggctga ttactattgc agctcctatg gatctagtag cacccatgtc      300

attttcggag gcggaacaaa ggtcaccgtc ctgagaaccg tggcggcgcc cagtgtcttc      360

atttttcccc ctagcgacga acagctgaag tctgggacag ccagtgtggt ctgtctgctg      420

aacaacttct accctcgcga ggctaaagtg cagtggaagg tcgataacgc actgcagtcc      480

ggaaattctc aggagagtgt gactgaacag gactcaaaag atagcaccta ttccctgtca      540

agcacactga ctctgagcaa ggccgactac gagaagcata aagtgtatgc ttgtgaagtc      600

acccaccagg ggctgagttc accagtcaca aaatcattca acagagggga gtgc            654


<210>  19
<211>  720
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  EP6b_B01 heavy chain Fab

<400>  19
cagctgcagc tgcaggaaag cgggcctggg ctggtgaaac cttccgaaac actgtccctg       60

acttgtactg tgagcggggc atcaattagt gccaactcat actatggcgt gtgggtccga      120

cagagtccag gaaagggact ggagtgggtg gggtccatcg cctacagagg aaacagtaat      180

tcaggcagca catactataa ccctagcctg aagtccaggg ctactgtgag cgtggacagc      240

tccaaaaatc aggtgtcact gcgcctgact agcgtcaccg ccgctgatac cgccctgtac      300

tattgcgctc ggagacagct gctggacgat gggacaggat accagtgggc agccttcgac      360

gtgtggggac aggggacaat ggtgactgtc tctagtgcta gcaccaaggg gccaagcgtg      420

ttcccactgg caccctcaag caaatccacc tctggaggaa cagctgcact gggatgcctg      480

gtgaaggatt atttccccga acctgtgact gtctcttgga atagtggggc actgacttct      540

ggagtgcaca cctttcccgc cgtcctgcag tcctctggac tgtactccct gagttcagtg      600

gtcacagtgc ctagctcctc tctgggcacc cagacataca tctgtaacgt gaaccataag      660

ccatcaaaca ctaaagtcga caagaaggtg gagccaaagt cctgtgacaa gacccataca      720


<210>  20
<211>  648
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  EP6b_B01 light chain (lambda)

<400>  20
cagagcgtcc tgactcagcc tccctccgtg tccgaagcac ctcggcagac tgtgactatc       60

tcatgttctg gcaactcatc aaatatcgga aggtacccag tgaactggta tcagcagctg      120

cccggcaagg cacctaaact gctgatctac agtgacaatc tgcggttctc aggggtcccc      180

gatcggttca gcggctccaa gtctgggacc acagccagcc tggctattcg ggacctgctg      240

tccgaggacg aagccgatta ctattgcagt acctgggacg ataccctgga aggatgggtc      300

ttcggcggcg gcacaaaagt caccgtcctg gggcagccaa aggcggcgcc cagtgtcaca      360

ctgtttcccc ctagctccga ggaactgcag gctaacaaag caacactggt gtgtctgatc      420

agcgacttct accctggagc tgtgactgtc gcctggaagg ctgattctag tccagtgaaa      480

gcaggcgtcg agaccacaac tccctctaag cagagtaaca acaagtacgc agcctcaagc      540

tatctgtcac tgaccccaga acagtggaag agccaccgga gctattcctg ccaggtcact      600

cacgaaggct ccactgtcga gaaaaccgtc gctcccaccg aatgttca                   648


<210>  21
<211>  651
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  EP6b_B01 V(lambda)-C(kappa) chimeric light chain

<400>  21
cagagcgtcc tgactcagcc tccttccgtg tccgaggcac cccgccagac cgtgactatc       60

tcatgttccg gcaactcctc aaatatcgga aggtacccag tgaactggta tcagcagctg      120

cccggcaagg cacctaaact gctgatctac agtgacaatc tgcggttctc aggggtcccc      180

gatcggttca gcggctccaa gtctgggacc acagccagcc tggctattcg ggacctgctg      240

tccgaggacg aagccgatta ctattgcagt acctgggatg ataccctgga aggatgggtc      300

tttggaggag gaactaaagt caccgtgctg agaaccgtgg cggcgcccag tgtcttcatt      360

tttcccccta gcgacgaaca gctgaagtct gggacagcca gtgtggtctg tctgctgaac      420

aacttctacc ctagagaggc taaagtgcag tggaaggtcg ataacgcact gcagtccgga      480

aattctcagg agagtgtgac tgaacaggac tcaaaagata gcacctattc cctgtcaagc      540

acactgactc tgagcaaggc cgactacgag aagcataaag tgtatgcttg tgaagtcacc      600

caccaggggc tgagttcacc agtcacaaaa tcattcaaca gaggggagtg c               651


<210>  22
<211>  678
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CAT-2200 heavy chain Fab

<400>  22
gaggtgcagc tgctggaatc tggggggggc ctggtgcagc ctggggggtc cctgagactg       60

tcatgtgctg ccagcgggtt tactttcagc tcctacgcta tgtcctgggt gcgacaggca      120

cccgggaagg gactggagtg ggtctctgca atcagtgggt caggcgggag tacttactat      180

gccgacagcg tgaagggacg gttcactatc tcaagagata acagcaagaa caccctgtat      240

ctgcagatga acagcctgag agcagaagac acagccgtgt actattgcgc cagggatctg      300

atccacggag tcactcgcaa ttggggccag gggactctgg tgaccgtctc tagtgctagc      360

acaaaggggc cctctgtgtt tccactggcc ccctcaagca aaagcacatc cggaggaact      420

gcagctctgg gatgtctggt gaaggactac ttcccccagc ctgtgaccgt ctcttggaac      480

agtggagccc tgaccagcgg cgtgcacaca tttcctgctg tcctgcagtc ctctggcctg      540

tactccctga gttcagtggt cacagtgcct agctcctctc tggggaccca gacatatatt      600

tgcaacgtga atcataaacc aagcaacact aaggtcgaca agaaagtgga gcccaagagc      660

tgtgataaaa ctcatacc                                                    678


<210>  23
<211>  648
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CAT-2200 light chain (lambda)

<400>  23
aactttatgc tgactcagcc ccactccgtg tccgagagcc ctggcaaaac tgtgactatt       60

tcatgtaccc gatcatctgg aagcctggcc aactactatg tgcagtggta ccagcagagg      120

ccaggcagct cccccactat cgtgattttc gctaacaatc agcggccttc cggcgtccca      180

gacagatttt ccgggtctat cgattctagt tcaaatagtg catcactgac tatttccggg      240

ctgaagaccg aggacgaagc cgattactat tgccagacct acgaccccta ttctgtggtc      300

ttcggcgggg gaaccaagct gacagtgctg ggacagccaa aagcggcgcc cagtgtcaca      360

ctgtttcccc ctagctccga ggaactgcag gctaacaaag caacactggt gtgtctgatc      420

agcgacttct accctggagc tgtgactgtc gcctggaagg ctgattctag tccagtgaaa      480

gcaggcgtcg agaccacaac tccctctaag cagagtaaca acaagtacgc agcctcaagc      540

tatctgtcac tgaccccaga acagtggaag agccaccgga gctattcctg ccaggtcact      600

cacgaaggct ccactgtcga gaaaaccgtc gctcccaccg aatgttca                   648


<210>  24
<211>  651
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CAT-2200 V(lambda)-C(kappa) chimeric light chain

<400>  24
aactttatgc tgacacagcc tcactctgtg agtgagtcac ccggaaagac cgtcacaatc       60

tcttgcacta ggagctccgg cagcctggca aactactatg tgcagtggta ccagcagcgg      120

cccgggtcta gtcctaccat cgtgattttc gccaacaatc agcgaccatc cggagtccca      180

gaccggttca gcgggtccat cgattcaagc tccaattctg ccagtctgac tattagcggc      240

ctgaaaaccg aggacgaagc tgattactat tgtcagacat acgatccata tagcgtggtc      300

tttggcggag gaactaagct gaccgtgctg agaaccgtgg cggcgcccag tgtcttcatt      360

tttcccccta gcgacgaaca gctgaagtct gggacagcca gtgtggtctg tctgctgaac      420

aacttctacc ctagagaggc taaagtgcag tggaaggtcg ataacgcact gcagtccgga      480

aattctcagg agagtgtgac tgaacaggac tcaaaagata gcacctattc cctgtcaagc      540

acactgactc tgagcaaggc cgactacgag aagcataaag tgtatgcttg tgaagtcacc      600

caccaggggc tgagttcacc agtcacaaaa tcattcaaca gaggggagtg c               651


<210>  25
<211>  681
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Pertuzumab heavy chain Fab

<400>  25
gaagtgcagc tggtcgaatc tggaggagga ctggtgcagc caggagggtc cctgcgcctg       60

tcttgcgccg ctagtggctt cacttttacc gactacacca tggattgggt gcgacaggca      120

cctggaaagg gcctggagtg ggtcgccgat gtgaacccaa atagcggagg ctccatctac      180

aaccagcggt tcaagggccg gttcaccctg tcagtggacc ggagcaaaaa caccctgtat      240

ctgcagatga atagcctgcg agccgaagat actgctgtgt actattgcgc ccggaatctg      300

gggccctcct tctactttga ctattggggg cagggaactc tggtcaccgt gagctccgcc      360

tccaccaagg gaccttctgt gttcccactg gctccctcta gtaaatccac atctggggga      420

actgcagccc tgggctgtct ggtgaaggac tacttcccag agcccgtcac agtgtcttgg      480

aacagtggcg ctctgacttc tggggtccac acctttcctg cagtgctgca gtcaagcggg      540

ctgtacagcc tgtcctctgt ggtcaccgtg ccaagttcaa gcctgggaac acagacttat      600

atctgcaacg tgaatcacaa gccatccaat acaaaagtcg acaagaaagt ggaacccaag      660

tcttgtgata aaacccatac a                                                681


<210>  26
<211>  642
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Pertuzumab light chain (kappa)

<400>  26
gatattcaga tgacccagtc cccaagctcc ctgagtgcct cagtgggcga ccgagtcacc       60

atcacatgca aggcttccca ggatgtgtct attggagtcg catggtacca gcagaagcca      120

ggcaaagcac ccaagctgct gatctatagc gcctcctacc ggtataccgg cgtgccctct      180

agattctctg gcagtgggtc aggaacagac tttactctga ccatctctag tctgcagcct      240

gaggatttcg ctacctacta ttgccagcag tactatatct acccatatac ctttggccag      300

gggacaaaag tggagatcaa gaggactgtg gccgctccct ccgtcttcat ttttccccct      360

tctgacgaac agctgaaaag tggcacagcc agcgtggtct gtctgctgaa caatttctac      420

cctcgcgaag ccaaagtgca gtggaaggtc gataacgctc tgcagagcgg caacagccag      480

gagtctgtga ctgaacagga cagtaaagat tcaacctata gcctgtcaag cacactgact      540

ctgagcaagg cagactacga gaagcacaaa gtgtatgcct gcgaagtcac acatcagggg      600

ctgtcctctc ctgtgactaa gagctttaac agaggagagt gt                         642


<210>  27
<211>  700
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  D3H44 heavy chain Fab

<400>  27
gaggtccagc tggtcgagtc tggaggagga ctggtgcagc caggagggag cctgcgactg       60

tcctgcgccg cttctggctt caacatcaag gaatactata tgcactgggt gagacaggca      120

ccaggcaaag gactggagtg ggtgggcctg atcgaccctg aacaggggaa caccatctac      180

gacccaaagt ttcaggatcg ggccactatt agtgctgaca actcaaaaaa taccgcatat      240

ctgcagatga acagcctgag ggcagaggat acagccgtgt actattgcgc ccgggacact      300

gcagcctact tcgattattg gggacagggc acactggtca ctgtgagctc cgctagcact      360

aaggggcctt ccgtgtttcc actggctccc tctagtaaat ccacctctgg aggcacagct      420

gcactgggat gtctggtgaa ggattacttc cctgaaccag tcacagtgag ttggaactca      480

ggggctctga caagtggagt ccatactttt cccgcagtgc tgcagtcaag cggactgtac      540

tccctgtcct ctgtggtcac cgtgcctagt tcaagcctgg gcacccagac atatatctgc      600

aacgtgaatc acaagccatc aaatacaaaa gtcgacaaga aagtggagcc caagagctgt      660

gataaaactc atacctgccc accttgtccg gcgccagaac                            700


<210>  28
<211>  642
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  D3H44 light chain (kappa)

<400>  28
gacatccaga tgacccagtc ccctagctcc ctgtccgcct ctgtgggcga cagggtgacc       60

atcacatgcc gggccagcag agatatcaag tcctacctga actggtatca gcagaagccc      120

ggcaaggccc ctaaggtgct gatctactat gccacatctc tggccgaggg agtgccaagc      180

cgcttcagcg gctccggctc tggaaccgac tacaccctga caatctctag cctgcagcca      240

gaggatttcg ccacatacta ttgtctgcag cacggcgagt ctccctggac ctttggccag      300

ggcacaaagg tggagatcaa gcggaccgtg gcggcgccca gtgtcttcat ttttccccct      360

agcgacgaac agctgaagtc tgggacagcc agtgtggtct gtctgctgaa caacttctac      420

cctagagagg ctaaagtgca gtggaaggtc gataacgcac tgcagtccgg aaattctcag      480

gagagtgtga ctgaacagga ctcaaaagat agcacctatt ccctgtcaag cacactgact      540

ctgagcaagg ccgactacga gaagcataaa gtgtatgctt gtgaagtcac ccaccagggg      600

ctgagttcac cagtcacaaa atcattcaac agaggggagt gc                         642


<210>  29
<211>  217
<212>  PRT
<213>  Homo sapiens


<220>
<223>  IgG1 Fc sequence 231-447

<400>  29

Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
1               5                   10                  15      


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            20                  25                  30          


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
        35                  40                  45              


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    50                  55                  60                  


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
65                  70                  75                  80  


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                85                  90                  95      


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
            100                 105                 110         


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu 
        115                 120                 125             


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
    130                 135                 140                 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
145                 150                 155                 160 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
                165                 170                 175     


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
            180                 185                 190         


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
        195                 200                 205             


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    210                 215         


<210>  30
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Upper IgG1 hinge

<400>  30

Glu Pro Lys Ser Cys Asp Lys Thr His Thr 
1               5                   10  


<210>  31
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C(kappa) (CH1) domain of IGKC*01

<400>  31

Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
1               5                   10                  15      


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
            20                  25                  30          


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
        35                  40                  45              


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
    50                  55                  60                  


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
65                  70                  75                  80  


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
                85                  90                  95      


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105         


<210>  32
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Lower IgG1 hinge

<400>  32

Cys Pro Pro Cys Pro 
1               5   


