                         SEQUENCE LISTING

<110>  Royal Melbourne Institute of Technology
       University of South Australia
       The Provost, Fellows, Foundation Scholars, and the other 
       members of Board, of the College of the Holy and Undivided 
       Trinity of Queen Elizabeth, near Dublin
       Monash University
 
<120>  A method of treatment

<130>  35284359/EJH

<150>  AU 2017902545
<151>  2017-06-30

<160>  57    

<170>  PatentIn version 3.5

<210>  1
<211>  10
<212>  PRT
<213>  artificial

<220>
<223>  peptide decoy D95 to L104 of murine TLR7

<400>  1

Asp Leu Arg Cys Asn Cys Val Pro Val Leu 
1               5                   10  


<210>  2
<211>  11
<212>  PRT
<213>  artificial

<220>
<223>  TAT

<400>  2

Thr Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg 
1               5                   10      


<210>  3
<211>  18
<212>  PRT
<213>  artificial

<220>
<223>  SynB1

<400>  3

Arg Gly Gly Arg Leu Ser Tyr Ser Arg Arg Arg Phe Ser Thr Ser Thr 
1               5                   10                  15      


Gly Arg 
        


<210>  4
<211>  10
<212>  PRT
<213>  artificial

<220>
<223>  SynB3

<400>  4

Arg Arg Leu Ser Tyr Ser Arg Arg Arg Phe 
1               5                   10  


<210>  5
<211>  12
<212>  PRT
<213>  artificial

<220>
<223>  PTD-4

<400>  5

Pro Ile Arg Arg Arg Lys Lys Leu Arg Arg Leu Lys 
1               5                   10          


<210>  6
<211>  12
<212>  PRT
<213>  artificial

<220>
<223>  PTD-5

<400>  6

Arg Arg Gln Arg Arg Thr Ser Lys Leu Met Lys Arg 
1               5                   10          


<210>  7
<211>  15
<212>  PRT
<213>  artificial

<220>
<223>  FHV Coat (35-49)

<400>  7

Arg Arg Arg Arg Asn Arg Thr Arg Arg Asn Arg Arg Arg Val Arg 
1               5                   10                  15  


<210>  8
<211>  19
<212>  PRT
<213>  artificial

<220>
<223>  BMV Gag (70-5)

<400>  8

Lys Met Thr Arg Ala Gln Arg Arg Ala Ala Ala Arg Arg Asn Arg Trp 
1               5                   10                  15      


Thr Ala Arg 
            


<210>  9
<211>  13
<212>  PRT
<213>  artificial

<220>
<223>  HTLV-II Rex (4-16)

<400>  9

Thr Arg Arg Gln Arg Thr Arg Arg Ala Arg Arg Asn Arg 
1               5                   10              


<210>  10
<211>  13
<212>  PRT
<213>  artificial

<220>
<223>  D-Tat

<400>  10

Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg Pro Pro Gln 
1               5                   10              


<210>  11
<211>  13
<212>  PRT
<213>  artificial

<220>
<223>  R9-Tat

<400>  11

Gly Arg Arg Arg Arg Arg Arg Arg Arg Arg Pro Pro Gln 
1               5                   10              


<210>  12
<211>  27
<212>  PRT
<213>  artificial

<220>
<223>  Transportan

<400>  12

Gly Trp Thr Leu Asn Ser Ala Gly Tyr Leu Leu Gly Lys Ile Asn Leu 
1               5                   10                  15      


Lys Ala Leu Ala Ala Leu Ala Lys Lys Ile Leu 
            20                  25          


<210>  13
<211>  17
<212>  PRT
<213>  artificial

<220>
<223>  MAP

<400>  13

Lys Leu Ala Leu Lys Leu Ala Leu Lys Leu Ala Leu Ala Leu Lys Leu 
1               5                   10                  15      


Ala 
    


<210>  14
<211>  27
<212>  PRT
<213>  artificial

<220>
<223>  SBP

<400>  14

Met Gly Leu Gly Leu His Leu Leu Val Leu Ala Ala Ala Leu Gln Gly 
1               5                   10                  15      


Ala Trp Ser Gln Pro Lys Lys Lys Arg Lys Val 
            20                  25          


<210>  15
<211>  27
<212>  PRT
<213>  artificial

<220>
<223>  FBP

<400>  15

Gly Ala Leu Phe Leu Gly Trp Leu Gly Ala Ala Gly Ser Thr Met Gly 
1               5                   10                  15      


Ala Trp Ser Gln Pro Lys Lys Lys Arg Lys Val 
            20                  25          


<210>  16
<211>  27
<212>  PRT
<213>  artificial

<220>
<223>  MPG ac

<400>  16

Gly Ala Leu Phe Leu Gly Phe Leu Gly Ala Ala Gly Ser Thr Met Gly 
1               5                   10                  15      


Ala Trp Ser Gln Pro Lys Lys Lys Arg Lys Val 
            20                  25          


<210>  17
<211>  27
<212>  PRT
<213>  artificial

<220>
<223>  MPG (NLS)

<400>  17

Gly Ala Leu Phe Leu Gly Phe Leu Gly Ala Ala Gly Ser Thr Met Gly 
1               5                   10                  15      


Ala Trp Ser Gln Pro Lys Ser Lys Arg Lys Val 
            20                  25          


<210>  18
<211>  21
<212>  PRT
<213>  artificial

<220>
<223>  Pep-1

<400>  18

Lys Glu Thr Trp Trp Glu Thr Trp Trp Thr Glu Trp Ser Gln Pro Lys 
1               5                   10                  15      


Lys Lys Arg Lys Val 
            20      


<210>  19
<211>  21
<212>  PRT
<213>  artificial

<220>
<223>  Pep-2

<400>  19

Lys Glu Thr Trp Phe Glu Thr Trp Phe Thr Glu Trp Ser Gln Pro Lys 
1               5                   10                  15      


Lys Lys Arg Lys Val 
            20      


<210>  20
<211>  1048
<212>  PRT
<213>  artificial

<220>
<223>  TLR7

<400>  20

Met Val Phe Pro Met Trp Thr Leu Lys Arg Leu Ile Leu Ile Leu Phe 
1               5                   10                  15      


Asn Ile Ile Leu Ile Ser Lys Leu Leu Gly Ala Arg Trp Phe Pro Lys 
            20                  25                  30          


Thr Leu Pro Cys Asp Val Thr Leu Asp Val Pro Lys Asn His Val Ile 
        35                  40                  45              


Val Asp Cys Thr Asp Lys His Leu Thr Glu Ile Pro Gly Gly Ile Pro 
    50                  55                  60                  


Thr Asn Thr Thr Asn Leu Thr Leu Thr Ile Asn His Ile Pro Asp Ile 
65                  70                  75                  80  


Ser Pro Ala Ser Phe His Arg Leu Asp His Leu Val Glu Ile Asp Phe 
                85                  90                  95      


Arg Cys Asn Cys Val Pro Ile Pro Leu Gly Ser Lys Asn Asn Met Cys 
            100                 105                 110         


Ile Lys Arg Leu Gln Ile Lys Pro Arg Ser Phe Ser Gly Leu Thr Tyr 
        115                 120                 125             


Leu Lys Ser Leu Tyr Leu Asp Gly Asn Gln Leu Leu Glu Ile Pro Gln 
    130                 135                 140                 


Gly Leu Pro Pro Ser Leu Gln Leu Leu Ser Leu Glu Ala Asn Asn Ile 
145                 150                 155                 160 


Phe Ser Ile Arg Lys Glu Asn Leu Thr Glu Leu Ala Asn Ile Glu Ile 
                165                 170                 175     


Leu Tyr Leu Gly Gln Asn Cys Tyr Tyr Arg Asn Pro Cys Tyr Val Ser 
            180                 185                 190         


Tyr Ser Ile Glu Lys Asp Ala Phe Leu Asn Leu Thr Lys Leu Lys Val 
        195                 200                 205             


Leu Ser Leu Lys Asp Asn Asn Val Thr Ala Val Pro Thr Val Leu Pro 
    210                 215                 220                 


Ser Thr Leu Thr Glu Leu Tyr Leu Tyr Asn Asn Met Ile Ala Lys Ile 
225                 230                 235                 240 


Gln Glu Asp Asp Phe Asn Asn Leu Asn Gln Leu Gln Ile Leu Asp Leu 
                245                 250                 255     


Ser Gly Asn Cys Pro Arg Cys Tyr Asn Ala Pro Phe Pro Cys Ala Pro 
            260                 265                 270         


Cys Lys Asn Asn Ser Pro Leu Gln Ile Pro Val Asn Ala Phe Asp Ala 
        275                 280                 285             


Leu Thr Glu Leu Lys Val Leu Arg Leu His Ser Asn Ser Leu Gln His 
    290                 295                 300                 


Val Pro Pro Arg Trp Phe Lys Asn Ile Asn Lys Leu Gln Glu Leu Asp 
305                 310                 315                 320 


Leu Ser Gln Asn Phe Leu Ala Lys Glu Ile Gly Asp Ala Lys Phe Leu 
                325                 330                 335     


His Phe Leu Pro Ser Leu Ile Gln Leu Asp Leu Ser Phe Asn Phe Glu 
            340                 345                 350         


Leu Gln Val Tyr Arg Ala Ser Met Asn Leu Ser Gln Ala Phe Ser Ser 
        355                 360                 365             


Leu Lys Ser Leu Lys Ile Leu Arg Ile Arg Gly Tyr Val Phe Lys Glu 
    370                 375                 380                 


Leu Lys Ser Phe Asn Leu Ser Pro Leu His Asn Leu Gln Asn Leu Glu 
385                 390                 395                 400 


Val Leu Asp Leu Gly Thr Asn Phe Ile Lys Ile Ala Asn Leu Ser Met 
                405                 410                 415     


Phe Lys Gln Phe Lys Arg Leu Lys Val Ile Asp Leu Ser Val Asn Lys 
            420                 425                 430         


Ile Ser Pro Ser Gly Asp Ser Ser Glu Val Gly Phe Cys Ser Asn Ala 
        435                 440                 445             


Arg Thr Ser Val Glu Ser Tyr Glu Pro Gln Val Leu Glu Gln Leu His 
    450                 455                 460                 


Tyr Phe Arg Tyr Asp Lys Tyr Arg Ser Cys Arg Phe Lys Asn Lys Glu 
465                 470                 475                 480 


Ala Ser Phe Met Ser Val Asn Glu Ser Cys Tyr Lys Tyr Gly Gln Thr 
                485                 490                 495     


Leu Asp Leu Ser Lys Asn Ser Ile Phe Phe Val Lys Ser Ser Asp Phe 
            500                 505                 510         


Gln His Leu Ser Phe Leu Lys Cys Leu Asn Leu Ser Gly Asn Leu Ile 
        515                 520                 525             


Ser Gln Thr Leu Asn Gly Ser Glu Phe Gln Pro Leu Ala Glu Leu Arg 
    530                 535                 540                 


Tyr Leu Asp Phe Ser Asn Asn Arg Leu Asp Leu Leu His Ser Thr Ala 
545                 550                 555                 560 


Phe Glu Glu Leu His Lys Leu Glu Val Leu Asp Ile Ser Ser Asn Ser 
                565                 570                 575     


His Tyr Phe Gln Ser Glu Gly Ile Thr His Met Leu Asn Phe Thr Lys 
            580                 585                 590         


Asn Leu Lys Val Leu Gln Lys Leu Met Met Asn Asp Asn Asp Ile Ser 
        595                 600                 605             


Ser Ser Thr Ser Arg Thr Met Glu Ser Glu Ser Leu Arg Thr Leu Glu 
    610                 615                 620                 


Phe Arg Gly Asn His Leu Asp Val Leu Trp Arg Glu Gly Asp Asn Arg 
625                 630                 635                 640 


Tyr Leu Gln Leu Phe Lys Asn Leu Leu Lys Leu Glu Glu Leu Asp Ile 
                645                 650                 655     


Ser Lys Asn Ser Leu Ser Phe Leu Pro Ser Gly Val Phe Asp Gly Met 
            660                 665                 670         


Pro Pro Asn Leu Lys Asn Leu Ser Leu Ala Lys Asn Gly Leu Lys Ser 
        675                 680                 685             


Phe Ser Trp Lys Lys Leu Gln Cys Leu Lys Asn Leu Glu Thr Leu Asp 
    690                 695                 700                 


Leu Ser His Asn Gln Leu Thr Thr Val Pro Glu Arg Leu Ser Asn Cys 
705                 710                 715                 720 


Ser Arg Ser Leu Lys Asn Leu Ile Leu Lys Asn Asn Gln Ile Arg Ser 
                725                 730                 735     


Leu Thr Lys Tyr Phe Leu Gln Asp Ala Phe Gln Leu Arg Tyr Leu Asp 
            740                 745                 750         


Leu Ser Ser Asn Lys Ile Gln Met Ile Gln Lys Thr Ser Phe Pro Glu 
        755                 760                 765             


Asn Val Leu Asn Asn Leu Lys Met Leu Leu Leu His His Asn Arg Phe 
    770                 775                 780                 


Leu Cys Thr Cys Asp Ala Val Trp Phe Val Trp Trp Val Asn His Thr 
785                 790                 795                 800 


Glu Val Thr Ile Pro Tyr Leu Ala Thr Asp Val Thr Cys Val Gly Pro 
                805                 810                 815     


Gly Ala His Lys Gly Gln Ser Val Ile Ser Leu Asp Leu Tyr Thr Cys 
            820                 825                 830         


Glu Leu Asp Leu Thr Asn Leu Ile Leu Phe Ser Leu Ser Ile Ser Val 
        835                 840                 845             


Ser Leu Phe Leu Met Val Met Met Thr Ala Ser His Leu Tyr Phe Trp 
    850                 855                 860                 


Asp Val Trp Tyr Ile Tyr His Phe Cys Lys Ala Lys Ile Lys Gly Tyr 
865                 870                 875                 880 


Gln Arg Leu Ile Ser Pro Asp Cys Cys Tyr Asp Ala Phe Ile Val Tyr 
                885                 890                 895     


Asp Thr Lys Asp Pro Ala Val Thr Glu Trp Val Leu Ala Glu Leu Val 
            900                 905                 910         


Ala Lys Leu Glu Asp Pro Arg Glu Lys His Phe Asn Leu Cys Leu Glu 
        915                 920                 925             


Glu Arg Asp Trp Leu Pro Gly Gln Pro Val Leu Glu Asn Leu Ser Gln 
    930                 935                 940                 


Ser Ile Gln Leu Ser Lys Lys Thr Val Phe Val Met Thr Asp Lys Tyr 
945                 950                 955                 960 


Ala Lys Thr Glu Asn Phe Lys Ile Ala Phe Tyr Leu Ser His Gln Arg 
                965                 970                 975     


Leu Met Asp Glu Lys Val Asp Val Ile Ile Leu Ile Phe Leu Glu Lys 
            980                 985                 990         


Pro Phe Gln Lys Ser Lys Phe Leu  Gln Leu Arg Lys Arg  Leu Cys Gly 
        995                 1000                 1005             


Ser Ser  Val Leu Glu Trp Pro  Thr Asn Pro Gln Ala  His Pro Tyr 
    1010                 1015                 1020             


Phe Trp  Gln Cys Leu Lys Asn  Ala Leu Ala Thr Asp  Asn His Val 
    1025                 1030                 1035             


Ala Tyr  Ser Gln Val Phe Lys  Glu Thr Val 
    1040                 1045             


<210>  21
<211>  19
<212>  DNA
<213>  artificial

<220>
<223>  Influenza polymerase forward primer

<400>  21
cggtccaaat tcctgctga                                                    19


<210>  22
<211>  20
<212>  DNA
<213>  artificial

<220>
<223>  Influenza polymerase reverse primer

<400>  22
cattgggttc cttccatcca                                                   20


<210>  23
<211>  22
<212>  PRT
<213>  artificial

<220>
<223>  gp91 ds-tat

<400>  23

Tyr Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg Cys Ser Thr Arg Ile 
1               5                   10                  15      


Arg Arg Gln Leu Asn His 
            20          


<210>  24
<211>  29
<212>  PRT
<213>  artificial

<220>
<223>  Sgp91 ds-tat

<400>  24

Pro Glu Gly Pro Glu Gly Pro Glu Gly Arg Lys Lys Arg Arg Gln Arg 
1               5                   10                  15      


Arg Arg Cys Leu Arg Ile Thr Arg Gln Ser Arg Asn His 
            20                  25                  


<210>  25
<211>  1050
<212>  PRT
<213>  artificial

<220>
<223>  Mus musculus TLR7

<400>  25

Met Val Phe Ser Met Trp Thr Arg Lys Arg Gln Ile Leu Ile Phe Leu 
1               5                   10                  15      


Asn Met Leu Leu Val Ser Arg Val Phe Gly Phe Arg Trp Phe Pro Lys 
            20                  25                  30          


Thr Leu Pro Cys Glu Val Lys Val Asn Ile Pro Glu Ala His Val Ile 
        35                  40                  45              


Val Asp Cys Thr Asp Lys His Leu Thr Glu Ile Pro Glu Gly Ile Pro 
    50                  55                  60                  


Thr Asn Thr Thr Asn Leu Thr Leu Thr Ile Asn His Ile Pro Ser Ile 
65                  70                  75                  80  


Ser Pro Asp Ser Phe Arg Arg Leu Asn His Leu Glu Glu Ile Asp Leu 
                85                  90                  95      


Arg Cys Asn Cys Val Pro Val Leu Leu Gly Ser Lys Ala Asn Val Cys 
            100                 105                 110         


Thr Lys Arg Leu Gln Ile Arg Pro Gly Ser Phe Ser Gly Leu Ser Asp 
        115                 120                 125             


Leu Lys Ala Leu Tyr Leu Asp Gly Asn Gln Leu Leu Glu Ile Pro Gln 
    130                 135                 140                 


Asp Leu Pro Ser Ser Leu His Leu Leu Ser Leu Glu Ala Asn Asn Ile 
145                 150                 155                 160 


Phe Ser Ile Thr Lys Glu Asn Leu Thr Glu Leu Val Asn Ile Glu Thr 
                165                 170                 175     


Leu Tyr Leu Gly Gln Asn Cys Tyr Tyr Arg Asn Pro Cys Asn Val Ser 
            180                 185                 190         


Tyr Ser Ile Glu Lys Asp Ala Phe Leu Val Met Arg Asn Leu Lys Val 
        195                 200                 205             


Leu Ser Leu Lys Asp Asn Asn Val Thr Ala Val Pro Thr Thr Leu Pro 
    210                 215                 220                 


Pro Asn Leu Leu Glu Leu Tyr Leu Tyr Asn Asn Ile Ile Lys Lys Ile 
225                 230                 235                 240 


Gln Glu Asn Asp Phe Asn Asn Leu Asn Glu Leu Gln Val Leu Asp Leu 
                245                 250                 255     


Ser Gly Asn Cys Pro Arg Cys Tyr Asn Val Pro Tyr Pro Cys Thr Pro 
            260                 265                 270         


Cys Glu Asn Asn Ser Pro Leu Gln Ile His Asp Asn Ala Phe Asn Ser 
        275                 280                 285             


Leu Thr Glu Leu Lys Val Leu Arg Leu His Ser Asn Ser Leu Gln His 
    290                 295                 300                 


Val Pro Pro Thr Trp Phe Lys Asn Met Arg Asn Leu Gln Glu Leu Asp 
305                 310                 315                 320 


Leu Ser Gln Asn Tyr Leu Ala Arg Glu Ile Glu Glu Ala Lys Phe Leu 
                325                 330                 335     


His Phe Leu Pro Asn Leu Val Glu Leu Asp Phe Ser Phe Asn Tyr Glu 
            340                 345                 350         


Leu Gln Val Tyr His Ala Ser Ile Thr Leu Pro His Ser Leu Ser Ser 
        355                 360                 365             


Leu Glu Asn Leu Lys Ile Leu Arg Val Lys Gly Tyr Val Phe Lys Glu 
    370                 375                 380                 


Leu Lys Asn Ser Ser Leu Ser Val Leu His Lys Leu Pro Arg Leu Glu 
385                 390                 395                 400 


Val Leu Asp Leu Gly Thr Asn Phe Ile Lys Ile Ala Asp Leu Asn Ile 
                405                 410                 415     


Phe Lys His Phe Glu Asn Leu Lys Leu Ile Asp Leu Ser Val Asn Lys 
            420                 425                 430         


Ile Ser Pro Ser Glu Glu Ser Arg Glu Val Gly Phe Cys Pro Asn Ala 
        435                 440                 445             


Gln Thr Ser Val Asp Arg His Gly Pro Gln Val Leu Glu Ala Leu His 
    450                 455                 460                 


Tyr Phe Arg Tyr Asp Glu Tyr Ala Arg Ser Cys Arg Phe Lys Asn Lys 
465                 470                 475                 480 


Glu Pro Pro Ser Phe Leu Pro Leu Asn Ala Asp Cys His Ile Tyr Gly 
                485                 490                 495     


Gln Thr Leu Asp Leu Ser Arg Asn Asn Ile Phe Phe Ile Lys Pro Ser 
            500                 505                 510         


Asp Phe Gln His Leu Ser Phe Leu Lys Cys Leu Asn Leu Ser Gly Asn 
        515                 520                 525             


Thr Ile Gly Gln Thr Leu Asn Gly Ser Glu Leu Trp Pro Leu Arg Glu 
    530                 535                 540                 


Leu Arg Tyr Leu Asp Phe Ser Asn Asn Arg Leu Asp Leu Leu Tyr Ser 
545                 550                 555                 560 


Thr Ala Phe Glu Glu Leu Gln Ser Leu Glu Val Leu Asp Leu Ser Ser 
                565                 570                 575     


Asn Ser His Tyr Phe Gln Ala Glu Gly Ile Thr His Met Leu Asn Phe 
            580                 585                 590         


Thr Lys Lys Leu Arg Leu Leu Asp Lys Leu Met Met Asn Asp Asn Asp 
        595                 600                 605             


Ile Ser Thr Ser Ala Ser Arg Thr Met Glu Ser Asp Ser Leu Arg Ile 
    610                 615                 620                 


Leu Glu Phe Arg Gly Asn His Leu Asp Val Leu Trp Arg Ala Gly Asp 
625                 630                 635                 640 


Asn Arg Tyr Leu Asp Phe Phe Lys Asn Leu Phe Asn Leu Glu Val Leu 
                645                 650                 655     


Asp Ile Ser Arg Asn Ser Leu Asn Ser Leu Pro Pro Glu Val Phe Glu 
            660                 665                 670         


Gly Met Pro Pro Asn Leu Lys Asn Leu Ser Leu Ala Lys Asn Gly Leu 
        675                 680                 685             


Lys Ser Phe Phe Trp Asp Arg Leu Gln Leu Leu Lys His Leu Glu Ile 
    690                 695                 700                 


Leu Asp Leu Ser His Asn Gln Leu Thr Lys Val Pro Glu Arg Leu Ala 
705                 710                 715                 720 


Asn Cys Ser Lys Ser Leu Thr Thr Leu Ile Leu Lys His Asn Gln Ile 
                725                 730                 735     


Arg Gln Leu Thr Lys Tyr Phe Leu Glu Asp Ala Leu Gln Leu Arg Tyr 
            740                 745                 750         


Leu Asp Ile Ser Ser Asn Lys Ile Gln Val Ile Gln Lys Thr Ser Phe 
        755                 760                 765             


Pro Glu Asn Val Leu Asn Asn Leu Glu Met Leu Val Leu His His Asn 
    770                 775                 780                 


Arg Phe Leu Cys Asn Cys Asp Ala Val Trp Phe Val Trp Trp Val Asn 
785                 790                 795                 800 


His Thr Asp Val Thr Ile Pro Tyr Leu Ala Thr Asp Val Thr Cys Val 
                805                 810                 815     


Gly Pro Gly Ala His Lys Gly Gln Ser Val Ile Ser Leu Asp Leu Tyr 
            820                 825                 830         


Thr Cys Glu Leu Asp Leu Thr Asn Leu Ile Leu Phe Ser Val Ser Ile 
        835                 840                 845             


Ser Ser Val Leu Phe Leu Met Val Val Met Thr Thr Ser His Leu Phe 
    850                 855                 860                 


Phe Trp Asp Met Trp Tyr Ile Tyr Tyr Phe Trp Lys Ala Lys Ile Lys 
865                 870                 875                 880 


Gly Tyr Gln His Leu Gln Ser Met Glu Ser Cys Tyr Asp Ala Phe Ile 
                885                 890                 895     


Val Tyr Asp Thr Lys Asn Ser Ala Val Thr Glu Trp Val Leu Gln Glu 
            900                 905                 910         


Leu Val Ala Lys Leu Glu Asp Pro Arg Glu Lys His Phe Asn Leu Cys 
        915                 920                 925             


Leu Glu Glu Arg Asp Trp Leu Pro Gly Gln Pro Val Leu Glu Asn Leu 
    930                 935                 940                 


Ser Gln Ser Ile Gln Leu Ser Lys Lys Thr Val Phe Val Met Thr Gln 
945                 950                 955                 960 


Lys Tyr Ala Lys Thr Glu Ser Phe Lys Met Ala Phe Tyr Leu Ser His 
                965                 970                 975     


Gln Arg Leu Leu Asp Glu Lys Val Asp Val Ile Ile Leu Ile Phe Leu 
            980                 985                 990         


Glu Lys Pro Leu Gln Lys Ser Lys  Phe Leu Gln Leu Arg  Lys Arg Leu 
        995                 1000                 1005             


Cys Arg  Ser Ser Val Leu Glu  Trp Pro Ala Asn Pro  Gln Ala His 
    1010                 1015                 1020             


Pro Tyr  Phe Trp Gln Cys Leu  Lys Asn Ala Leu Thr  Thr Asp Asn 
    1025                 1030                 1035             


His Val  Ala Tyr Ser Gln Met  Phe Lys Glu Thr Val  
    1040                 1045                 1050 


<210>  26
<211>  10
<212>  PRT
<213>  artificial

<220>
<223>  peptide decoy D95 to L104 of Homo sapiens TLR7

<400>  26

Asp Phe Arg Cys Asn Cys Val Pro Ile Pro 
1               5                   10  


<210>  27
<211>  10
<212>  PRT
<213>  artificial

<220>
<223>  peptide decoy


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  X = L, F or M

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  X = V or I

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  X = V or I or A or P

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  X = L or K or R

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  X = P or L or K or R

<400>  27

Asp Xaa Arg Cys Asn Cys Xaa Pro Xaa Xaa 
1               5                   10  


<210>  28
<211>  904
<212>  PRT
<213>  artificial

<220>
<223>  Homo sapiens TLR3

<400>  28

Met Arg Gln Thr Leu Pro Cys Ile Tyr Phe Trp Gly Gly Leu Leu Pro 
1               5                   10                  15      


Phe Gly Met Leu Cys Ala Ser Ser Thr Thr Lys Cys Thr Val Ser His 
            20                  25                  30          


Glu Val Ala Asp Cys Ser His Leu Lys Leu Thr Gln Val Pro Asp Asp 
        35                  40                  45              


Leu Pro Thr Asn Ile Thr Val Leu Asn Leu Thr His Asn Gln Leu Arg 
    50                  55                  60                  


Arg Leu Pro Ala Ala Asn Phe Thr Arg Tyr Ser Gln Leu Thr Ser Leu 
65                  70                  75                  80  


Asp Val Gly Phe Asn Thr Ile Ser Lys Leu Glu Pro Glu Leu Cys Gln 
                85                  90                  95      


Lys Leu Pro Met Leu Lys Val Leu Asn Leu Gln His Asn Glu Leu Ser 
            100                 105                 110         


Gln Leu Ser Asp Lys Thr Phe Ala Phe Cys Thr Asn Leu Thr Glu Leu 
        115                 120                 125             


His Leu Met Ser Asn Ser Ile Gln Lys Ile Lys Asn Asn Pro Phe Val 
    130                 135                 140                 


Lys Gln Lys Asn Leu Ile Thr Leu Asp Leu Ser His Asn Gly Leu Ser 
145                 150                 155                 160 


Ser Thr Lys Leu Gly Thr Gln Val Gln Leu Glu Asn Leu Gln Glu Leu 
                165                 170                 175     


Leu Leu Ser Asn Asn Lys Ile Gln Ala Leu Lys Ser Glu Glu Leu Asp 
            180                 185                 190         


Ile Phe Ala Asn Ser Ser Leu Lys Lys Leu Glu Leu Ser Ser Asn Gln 
        195                 200                 205             


Ile Lys Glu Phe Ser Pro Gly Cys Phe His Ala Ile Gly Arg Leu Phe 
    210                 215                 220                 


Gly Leu Phe Leu Asn Asn Val Gln Leu Gly Pro Ser Leu Thr Glu Lys 
225                 230                 235                 240 


Leu Cys Leu Glu Leu Ala Asn Thr Ser Ile Arg Asn Leu Ser Leu Ser 
                245                 250                 255     


Asn Ser Gln Leu Ser Thr Thr Ser Asn Thr Thr Phe Leu Gly Leu Lys 
            260                 265                 270         


Trp Thr Asn Leu Thr Met Leu Asp Leu Ser Tyr Asn Asn Leu Asn Val 
        275                 280                 285             


Val Gly Asn Asp Ser Phe Ala Trp Leu Pro Gln Leu Glu Tyr Phe Phe 
    290                 295                 300                 


Leu Glu Tyr Asn Asn Ile Gln His Leu Phe Ser His Ser Leu His Gly 
305                 310                 315                 320 


Leu Phe Asn Val Arg Tyr Leu Asn Leu Lys Arg Ser Phe Thr Lys Gln 
                325                 330                 335     


Ser Ile Ser Leu Ala Ser Leu Pro Lys Ile Asp Asp Phe Ser Phe Gln 
            340                 345                 350         


Trp Leu Lys Cys Leu Glu His Leu Asn Met Glu Asp Asn Asp Ile Pro 
        355                 360                 365             


Gly Ile Lys Ser Asn Met Phe Thr Gly Leu Ile Asn Leu Lys Tyr Leu 
    370                 375                 380                 


Ser Leu Ser Asn Ser Phe Thr Ser Leu Arg Thr Leu Thr Asn Glu Thr 
385                 390                 395                 400 


Phe Val Ser Leu Ala His Ser Pro Leu His Ile Leu Asn Leu Thr Lys 
                405                 410                 415     


Asn Lys Ile Ser Lys Ile Glu Ser Asp Ala Phe Ser Trp Leu Gly His 
            420                 425                 430         


Leu Glu Val Leu Asp Leu Gly Leu Asn Glu Ile Gly Gln Glu Leu Thr 
        435                 440                 445             


Gly Gln Glu Trp Arg Gly Leu Glu Asn Ile Phe Glu Ile Tyr Leu Ser 
    450                 455                 460                 


Tyr Asn Lys Tyr Leu Gln Leu Thr Arg Asn Ser Phe Ala Leu Val Pro 
465                 470                 475                 480 


Ser Leu Gln Arg Leu Met Leu Arg Arg Val Ala Leu Lys Asn Val Asp 
                485                 490                 495     


Ser Ser Pro Ser Pro Phe Gln Pro Leu Arg Asn Leu Thr Ile Leu Asp 
            500                 505                 510         


Leu Ser Asn Asn Asn Ile Ala Asn Ile Asn Asp Asp Met Leu Glu Gly 
        515                 520                 525             


Leu Glu Lys Leu Glu Ile Leu Asp Leu Gln His Asn Asn Leu Ala Arg 
    530                 535                 540                 


Leu Trp Lys His Ala Asn Pro Gly Gly Pro Ile Tyr Phe Leu Lys Gly 
545                 550                 555                 560 


Leu Ser His Leu His Ile Leu Asn Leu Glu Ser Asn Gly Phe Asp Glu 
                565                 570                 575     


Ile Pro Val Glu Val Phe Lys Asp Leu Phe Glu Leu Lys Ile Ile Asp 
            580                 585                 590         


Leu Gly Leu Asn Asn Leu Asn Thr Leu Pro Ala Ser Val Phe Asn Asn 
        595                 600                 605             


Gln Val Ser Leu Lys Ser Leu Asn Leu Gln Lys Asn Leu Ile Thr Ser 
    610                 615                 620                 


Val Glu Lys Lys Val Phe Gly Pro Ala Phe Arg Asn Leu Thr Glu Leu 
625                 630                 635                 640 


Asp Met Arg Phe Asn Pro Phe Asp Cys Thr Cys Glu Ser Ile Ala Trp 
                645                 650                 655     


Phe Val Asn Trp Ile Asn Glu Thr His Thr Asn Ile Pro Glu Leu Ser 
            660                 665                 670         


Ser His Tyr Leu Cys Asn Thr Pro Pro His Tyr His Gly Phe Pro Val 
        675                 680                 685             


Arg Leu Phe Asp Thr Ser Ser Cys Lys Asp Ser Ala Pro Phe Glu Leu 
    690                 695                 700                 


Phe Phe Met Ile Asn Thr Ser Ile Leu Leu Ile Phe Ile Phe Ile Val 
705                 710                 715                 720 


Leu Leu Ile His Phe Glu Gly Trp Arg Ile Ser Phe Tyr Trp Asn Val 
                725                 730                 735     


Ser Val His Arg Val Leu Gly Phe Lys Glu Ile Asp Arg Gln Thr Glu 
            740                 745                 750         


Gln Phe Glu Tyr Ala Ala Tyr Ile Ile His Ala Tyr Lys Asp Lys Asp 
        755                 760                 765             


Trp Val Trp Glu His Phe Ser Ser Met Glu Lys Glu Asp Gln Ser Leu 
    770                 775                 780                 


Lys Phe Cys Leu Glu Glu Arg Asp Phe Glu Ala Gly Val Phe Glu Leu 
785                 790                 795                 800 


Glu Ala Ile Val Asn Ser Ile Lys Arg Ser Arg Lys Ile Ile Phe Val 
                805                 810                 815     


Ile Thr His His Leu Leu Lys Asp Pro Leu Cys Lys Arg Phe Lys Val 
            820                 825                 830         


His His Ala Val Gln Gln Ala Ile Glu Gln Asn Leu Asp Ser Ile Ile 
        835                 840                 845             


Leu Val Phe Leu Glu Glu Ile Pro Asp Tyr Lys Leu Asn His Ala Leu 
    850                 855                 860                 


Cys Leu Arg Arg Gly Met Phe Lys Ser His Cys Ile Leu Asn Trp Pro 
865                 870                 875                 880 


Val Gln Lys Glu Arg Ile Gly Ala Phe Arg His Lys Leu Gln Val Ala 
                885                 890                 895     


Leu Gly Ser Lys Asn Ser Val His 
            900                 


<210>  29
<211>  1032
<212>  PRT
<213>  artificial

<220>
<223>  Homo sapiens TLR9

<400>  29

Met Gly Phe Cys Arg Ser Ala Leu His Pro Leu Ser Leu Leu Val Gln 
1               5                   10                  15      


Ala Ile Met Leu Ala Met Thr Leu Ala Leu Gly Thr Leu Pro Ala Phe 
            20                  25                  30          


Leu Pro Cys Glu Leu Gln Pro His Gly Leu Val Asn Cys Asn Trp Leu 
        35                  40                  45              


Phe Leu Lys Ser Val Pro His Phe Ser Met Ala Ala Pro Arg Gly Asn 
    50                  55                  60                  


Val Thr Ser Leu Ser Leu Ser Ser Asn Arg Ile His His Leu His Asp 
65                  70                  75                  80  


Ser Asp Phe Ala His Leu Pro Ser Leu Arg His Leu Asn Leu Lys Trp 
                85                  90                  95      


Asn Cys Pro Pro Val Gly Leu Ser Pro Met His Phe Pro Cys His Met 
            100                 105                 110         


Thr Ile Glu Pro Ser Thr Phe Leu Ala Val Pro Thr Leu Glu Glu Leu 
        115                 120                 125             


Asn Leu Ser Tyr Asn Asn Ile Met Thr Val Pro Ala Leu Pro Lys Ser 
    130                 135                 140                 


Leu Ile Ser Leu Ser Leu Ser His Thr Asn Ile Leu Met Leu Asp Ser 
145                 150                 155                 160 


Ala Ser Leu Ala Gly Leu His Ala Leu Arg Phe Leu Phe Met Asp Gly 
                165                 170                 175     


Asn Cys Tyr Tyr Lys Asn Pro Cys Arg Gln Ala Leu Glu Val Ala Pro 
            180                 185                 190         


Gly Ala Leu Leu Gly Leu Gly Asn Leu Thr His Leu Ser Leu Lys Tyr 
        195                 200                 205             


Asn Asn Leu Thr Val Val Pro Arg Asn Leu Pro Ser Ser Leu Glu Tyr 
    210                 215                 220                 


Leu Leu Leu Ser Tyr Asn Arg Ile Val Lys Leu Ala Pro Glu Asp Leu 
225                 230                 235                 240 


Ala Asn Leu Thr Ala Leu Arg Val Leu Asp Val Gly Gly Asn Cys Arg 
                245                 250                 255     


Arg Cys Asp His Ala Pro Asn Pro Cys Met Glu Cys Pro Arg His Phe 
            260                 265                 270         


Pro Gln Leu His Pro Asp Thr Phe Ser His Leu Ser Arg Leu Glu Gly 
        275                 280                 285             


Leu Val Leu Lys Asp Ser Ser Leu Ser Trp Leu Asn Ala Ser Trp Phe 
    290                 295                 300                 


Arg Gly Leu Gly Asn Leu Arg Val Leu Asp Leu Ser Glu Asn Phe Leu 
305                 310                 315                 320 


Tyr Lys Cys Ile Thr Lys Thr Lys Ala Phe Gln Gly Leu Thr Gln Leu 
                325                 330                 335     


Arg Lys Leu Asn Leu Ser Phe Asn Tyr Gln Lys Arg Val Ser Phe Ala 
            340                 345                 350         


His Leu Ser Leu Ala Pro Ser Phe Gly Ser Leu Val Ala Leu Lys Glu 
        355                 360                 365             


Leu Asp Met His Gly Ile Phe Phe Arg Ser Leu Asp Glu Thr Thr Leu 
    370                 375                 380                 


Arg Pro Leu Ala Arg Leu Pro Met Leu Gln Thr Leu Arg Leu Gln Met 
385                 390                 395                 400 


Asn Phe Ile Asn Gln Ala Gln Leu Gly Ile Phe Arg Ala Phe Pro Gly 
                405                 410                 415     


Leu Arg Tyr Val Asp Leu Ser Asp Asn Arg Ile Ser Gly Ala Ser Glu 
            420                 425                 430         


Leu Thr Ala Thr Met Gly Glu Ala Asp Gly Gly Glu Lys Val Trp Leu 
        435                 440                 445             


Gln Pro Gly Asp Leu Ala Pro Ala Pro Val Asp Thr Pro Ser Ser Glu 
    450                 455                 460                 


Asp Phe Arg Pro Asn Cys Ser Thr Leu Asn Phe Thr Leu Asp Leu Ser 
465                 470                 475                 480 


Arg Asn Asn Leu Val Thr Val Gln Pro Glu Met Phe Ala Gln Leu Ser 
                485                 490                 495     


His Leu Gln Cys Leu Arg Leu Ser His Asn Cys Ile Ser Gln Ala Val 
            500                 505                 510         


Asn Gly Ser Gln Phe Leu Pro Leu Thr Gly Leu Gln Val Leu Asp Leu 
        515                 520                 525             


Ser His Asn Lys Leu Asp Leu Tyr His Glu His Ser Phe Thr Glu Leu 
    530                 535                 540                 


Pro Arg Leu Glu Ala Leu Asp Leu Ser Tyr Asn Ser Gln Pro Phe Gly 
545                 550                 555                 560 


Met Gln Gly Val Gly His Asn Phe Ser Phe Val Ala His Leu Arg Thr 
                565                 570                 575     


Leu Arg His Leu Ser Leu Ala His Asn Asn Ile His Ser Gln Val Ser 
            580                 585                 590         


Gln Gln Leu Cys Ser Thr Ser Leu Arg Ala Leu Asp Phe Ser Gly Asn 
        595                 600                 605             


Ala Leu Gly His Met Trp Ala Glu Gly Asp Leu Tyr Leu His Phe Phe 
    610                 615                 620                 


Gln Gly Leu Ser Gly Leu Ile Trp Leu Asp Leu Ser Gln Asn Arg Leu 
625                 630                 635                 640 


His Thr Leu Leu Pro Gln Thr Leu Arg Asn Leu Pro Lys Ser Leu Gln 
                645                 650                 655     


Val Leu Arg Leu Arg Asp Asn Tyr Leu Ala Phe Phe Lys Trp Trp Ser 
            660                 665                 670         


Leu His Phe Leu Pro Lys Leu Glu Val Leu Asp Leu Ala Gly Asn Gln 
        675                 680                 685             


Leu Lys Ala Leu Thr Asn Gly Ser Leu Pro Ala Gly Thr Arg Leu Arg 
    690                 695                 700                 


Arg Leu Asp Val Ser Cys Asn Ser Ile Ser Phe Val Ala Pro Gly Phe 
705                 710                 715                 720 


Phe Ser Lys Ala Lys Glu Leu Arg Glu Leu Asn Leu Ser Ala Asn Ala 
                725                 730                 735     


Leu Lys Thr Val Asp His Ser Trp Phe Gly Pro Leu Ala Ser Ala Leu 
            740                 745                 750         


Gln Ile Leu Asp Val Ser Ala Asn Pro Leu His Cys Ala Cys Gly Ala 
        755                 760                 765             


Ala Phe Met Asp Phe Leu Leu Glu Val Gln Ala Ala Val Pro Gly Leu 
    770                 775                 780                 


Pro Ser Arg Val Lys Cys Gly Ser Pro Gly Gln Leu Gln Gly Leu Ser 
785                 790                 795                 800 


Ile Phe Ala Gln Asp Leu Arg Leu Cys Leu Asp Glu Ala Leu Ser Trp 
                805                 810                 815     


Asp Cys Phe Ala Leu Ser Leu Leu Ala Val Ala Leu Gly Leu Gly Val 
            820                 825                 830         


Pro Met Leu His His Leu Cys Gly Trp Asp Leu Trp Tyr Cys Phe His 
        835                 840                 845             


Leu Cys Leu Ala Trp Leu Pro Trp Arg Gly Arg Gln Ser Gly Arg Asp 
    850                 855                 860                 


Glu Asp Ala Leu Pro Tyr Asp Ala Phe Val Val Phe Asp Lys Thr Gln 
865                 870                 875                 880 


Ser Ala Val Ala Asp Trp Val Tyr Asn Glu Leu Arg Gly Gln Leu Glu 
                885                 890                 895     


Glu Cys Arg Gly Arg Trp Ala Leu Arg Leu Cys Leu Glu Glu Arg Asp 
            900                 905                 910         


Trp Leu Pro Gly Lys Thr Leu Phe Glu Asn Leu Trp Ala Ser Val Tyr 
        915                 920                 925             


Gly Ser Arg Lys Thr Leu Phe Val Leu Ala His Thr Asp Arg Val Ser 
    930                 935                 940                 


Gly Leu Leu Arg Ala Ser Phe Leu Leu Ala Gln Gln Arg Leu Leu Glu 
945                 950                 955                 960 


Asp Arg Lys Asp Val Val Val Leu Val Ile Leu Ser Pro Asp Gly Arg 
                965                 970                 975     


Arg Ser Arg Tyr Val Arg Leu Arg Gln Arg Leu Cys Arg Gln Ser Val 
            980                 985                 990         


Leu Leu Trp Pro His Gln Pro Ser  Gly Gln Arg Ser Phe  Trp Ala Gln 
        995                 1000                 1005             


Leu Gly  Met Ala Leu Thr Arg  Asp Asn His His Phe  Tyr Asn Arg 
    1010                 1015                 1020             


Asn Phe  Cys Gln Gly Pro Thr  Ala Glu 
    1025                 1030         


<210>  30
<211>  1059
<212>  PRT
<213>  artificial

<220>
<223>  Homo sapiens TLR8

<400>  30

Met Lys Glu Ser Ser Leu Gln Asn Ser Ser Cys Ser Leu Gly Lys Glu 
1               5                   10                  15      


Thr Lys Lys Glu Asn Met Phe Leu Gln Ser Ser Met Leu Thr Cys Ile 
            20                  25                  30          


Phe Leu Leu Ile Ser Gly Ser Cys Glu Leu Cys Ala Glu Glu Asn Phe 
        35                  40                  45              


Ser Arg Ser Tyr Pro Cys Asp Glu Lys Lys Gln Asn Asp Ser Val Ile 
    50                  55                  60                  


Ala Glu Cys Ser Asn Arg Arg Leu Gln Glu Val Pro Gln Thr Val Gly 
65                  70                  75                  80  


Lys Tyr Val Thr Glu Leu Asp Leu Ser Asp Asn Phe Ile Thr His Ile 
                85                  90                  95      


Thr Asn Glu Ser Phe Gln Gly Leu Gln Asn Leu Thr Lys Ile Asn Leu 
            100                 105                 110         


Asn His Asn Pro Asn Val Gln His Gln Asn Gly Asn Pro Gly Ile Gln 
        115                 120                 125             


Ser Asn Gly Leu Asn Ile Thr Asp Gly Ala Phe Leu Asn Leu Lys Asn 
    130                 135                 140                 


Leu Arg Glu Leu Leu Leu Glu Asp Asn Gln Leu Pro Gln Ile Pro Ser 
145                 150                 155                 160 


Gly Leu Pro Glu Ser Leu Thr Glu Leu Ser Leu Ile Gln Asn Asn Ile 
                165                 170                 175     


Tyr Asn Ile Thr Lys Glu Gly Ile Ser Arg Leu Ile Asn Leu Lys Asn 
            180                 185                 190         


Leu Tyr Leu Ala Trp Asn Cys Tyr Phe Asn Lys Val Cys Glu Lys Thr 
        195                 200                 205             


Asn Ile Glu Asp Gly Val Phe Glu Thr Leu Thr Asn Leu Glu Leu Leu 
    210                 215                 220                 


Ser Leu Ser Phe Asn Ser Leu Ser His Val Pro Pro Lys Leu Pro Ser 
225                 230                 235                 240 


Ser Leu Arg Lys Leu Phe Leu Ser Asn Thr Gln Ile Lys Tyr Ile Ser 
                245                 250                 255     


Glu Glu Asp Phe Lys Gly Leu Ile Asn Leu Thr Leu Leu Asp Leu Ser 
            260                 265                 270         


Gly Asn Cys Pro Arg Cys Phe Asn Ala Pro Phe Pro Cys Val Pro Cys 
        275                 280                 285             


Asp Gly Gly Ala Ser Ile Asn Ile Asp Arg Phe Ala Phe Gln Asn Leu 
    290                 295                 300                 


Thr Gln Leu Arg Tyr Leu Asn Leu Ser Ser Thr Ser Leu Arg Lys Ile 
305                 310                 315                 320 


Asn Ala Ala Trp Phe Lys Asn Met Pro His Leu Lys Val Leu Asp Leu 
                325                 330                 335     


Glu Phe Asn Tyr Leu Val Gly Glu Ile Ala Ser Gly Ala Phe Leu Thr 
            340                 345                 350         


Met Leu Pro Arg Leu Glu Ile Leu Asp Leu Ser Phe Asn Tyr Ile Lys 
        355                 360                 365             


Gly Ser Tyr Pro Gln His Ile Asn Ile Ser Arg Asn Phe Ser Lys Leu 
    370                 375                 380                 


Leu Ser Leu Arg Ala Leu His Leu Arg Gly Tyr Val Phe Gln Glu Leu 
385                 390                 395                 400 


Arg Glu Asp Asp Phe Gln Pro Leu Met Gln Leu Pro Asn Leu Ser Thr 
                405                 410                 415     


Ile Asn Leu Gly Ile Asn Phe Ile Lys Gln Ile Asp Phe Lys Leu Phe 
            420                 425                 430         


Gln Asn Phe Ser Asn Leu Glu Ile Ile Tyr Leu Ser Glu Asn Arg Ile 
        435                 440                 445             


Ser Pro Leu Val Lys Asp Thr Arg Gln Ser Tyr Ala Asn Ser Ser Ser 
    450                 455                 460                 


Phe Gln Arg His Ile Arg Lys Arg Arg Ser Thr Asp Phe Glu Phe Asp 
465                 470                 475                 480 


Pro His Ser Asn Phe Tyr His Phe Thr Arg Pro Leu Ile Lys Pro Gln 
                485                 490                 495     


Cys Ala Ala Tyr Gly Lys Ala Leu Asp Leu Ser Leu Asn Ser Ile Phe 
            500                 505                 510         


Phe Ile Gly Pro Asn Gln Phe Glu Asn Leu Pro Asp Ile Ala Cys Leu 
        515                 520                 525             


Asn Leu Ser Ala Asn Ser Asn Ala Gln Val Leu Ser Gly Thr Glu Phe 
    530                 535                 540                 


Ser Ala Ile Pro His Val Lys Tyr Leu Asp Leu Thr Asn Asn Arg Leu 
545                 550                 555                 560 


Asp Phe Asp Asn Ala Ser Ala Leu Thr Glu Leu Ser Asp Leu Glu Val 
                565                 570                 575     


Leu Asp Leu Ser Tyr Asn Ser His Tyr Phe Arg Ile Ala Gly Val Thr 
            580                 585                 590         


His His Leu Glu Phe Ile Gln Asn Phe Thr Asn Leu Lys Val Leu Asn 
        595                 600                 605             


Leu Ser His Asn Asn Ile Tyr Thr Leu Thr Asp Lys Tyr Asn Leu Glu 
    610                 615                 620                 


Ser Lys Ser Leu Val Glu Leu Val Phe Ser Gly Asn Arg Leu Asp Ile 
625                 630                 635                 640 


Leu Trp Asn Asp Asp Asp Asn Arg Tyr Ile Ser Ile Phe Lys Gly Leu 
                645                 650                 655     


Lys Asn Leu Thr Arg Leu Asp Leu Ser Leu Asn Arg Leu Lys His Ile 
            660                 665                 670         


Pro Asn Glu Ala Phe Leu Asn Leu Pro Ala Ser Leu Thr Glu Leu His 
        675                 680                 685             


Ile Asn Asp Asn Met Leu Lys Phe Phe Asn Trp Thr Leu Leu Gln Gln 
    690                 695                 700                 


Phe Pro Arg Leu Glu Leu Leu Asp Leu Arg Gly Asn Lys Leu Leu Phe 
705                 710                 715                 720 


Leu Thr Asp Ser Leu Ser Asp Phe Thr Ser Ser Leu Arg Thr Leu Leu 
                725                 730                 735     


Leu Ser His Asn Arg Ile Ser His Leu Pro Ser Gly Phe Leu Ser Glu 
            740                 745                 750         


Val Ser Ser Leu Lys His Leu Asp Leu Ser Ser Asn Leu Leu Lys Thr 
        755                 760                 765             


Ile Asn Lys Ser Ala Leu Glu Thr Lys Thr Thr Thr Lys Leu Ser Met 
    770                 775                 780                 


Leu Glu Leu His Gly Asn Pro Phe Glu Cys Thr Cys Asp Ile Gly Asp 
785                 790                 795                 800 


Phe Arg Arg Trp Met Asp Glu His Leu Asn Val Lys Ile Pro Arg Leu 
                805                 810                 815     


Val Asp Val Ile Cys Ala Ser Pro Gly Asp Gln Arg Gly Lys Ser Ile 
            820                 825                 830         


Val Ser Leu Glu Leu Thr Thr Cys Val Ser Asp Val Thr Ala Val Ile 
        835                 840                 845             


Leu Phe Phe Phe Thr Phe Phe Ile Thr Thr Met Val Met Leu Ala Ala 
    850                 855                 860                 


Leu Ala His His Leu Phe Tyr Trp Asp Val Trp Phe Ile Tyr Asn Val 
865                 870                 875                 880 


Cys Leu Ala Lys Val Lys Gly Tyr Arg Ser Leu Ser Thr Ser Gln Thr 
                885                 890                 895     


Phe Tyr Asp Ala Tyr Ile Ser Tyr Asp Thr Lys Asp Ala Ser Val Thr 
            900                 905                 910         


Asp Trp Val Ile Asn Glu Leu Arg Tyr His Leu Glu Glu Ser Arg Asp 
        915                 920                 925             


Lys Asn Val Leu Leu Cys Leu Glu Glu Arg Asp Trp Asp Pro Gly Leu 
    930                 935                 940                 


Ala Ile Ile Asp Asn Leu Met Gln Ser Ile Asn Gln Ser Lys Lys Thr 
945                 950                 955                 960 


Val Phe Val Leu Thr Lys Lys Tyr Ala Lys Ser Trp Asn Phe Lys Thr 
                965                 970                 975     


Ala Phe Tyr Leu Ala Leu Gln Arg Leu Met Asp Glu Asn Met Asp Val 
            980                 985                 990         


Ile Ile Phe Ile Leu Leu Glu Pro  Val Leu Gln His Ser  Gln Tyr Leu 
        995                 1000                 1005             


Arg Leu  Arg Gln Arg Ile Cys  Lys Ser Ser Ile Leu  Gln Trp Pro 
    1010                 1015                 1020             


Asp Asn  Pro Lys Ala Glu Gly  Leu Phe Trp Gln Thr  Leu Arg Asn 
    1025                 1030                 1035             


Val Val  Leu Thr Glu Asn Asp  Ser Arg Tyr Asn Asn  Met Tyr Val 
    1040                 1045                 1050             


Asp Ser  Ile Lys Gln Tyr 
    1055                 


<210>  31
<211>  858
<212>  PRT
<213>  artificial

<220>
<223>  Homo sapiens TLR5

<400>  31

Met Gly Asp His Leu Asp Leu Leu Leu Gly Val Val Leu Met Ala Gly 
1               5                   10                  15      


Pro Val Phe Gly Ile Pro Ser Cys Ser Phe Asp Gly Arg Ile Ala Phe 
            20                  25                  30          


Tyr Arg Phe Cys Asn Leu Thr Gln Val Pro Gln Val Leu Asn Thr Thr 
        35                  40                  45              


Glu Arg Leu Leu Leu Ser Phe Asn Tyr Ile Arg Thr Val Thr Ala Ser 
    50                  55                  60                  


Ser Phe Pro Phe Leu Glu Gln Leu Gln Leu Leu Glu Leu Gly Ser Gln 
65                  70                  75                  80  


Tyr Thr Pro Leu Thr Ile Asp Lys Glu Ala Phe Arg Asn Leu Pro Asn 
                85                  90                  95      


Leu Arg Ile Leu Asp Leu Gly Ser Ser Lys Ile Tyr Phe Leu His Pro 
            100                 105                 110         


Asp Ala Phe Gln Gly Leu Phe His Leu Phe Glu Leu Arg Leu Tyr Phe 
        115                 120                 125             


Cys Gly Leu Ser Asp Ala Val Leu Lys Asp Gly Tyr Phe Arg Asn Leu 
    130                 135                 140                 


Lys Ala Leu Thr Arg Leu Asp Leu Ser Lys Asn Gln Ile Arg Ser Leu 
145                 150                 155                 160 


Tyr Leu His Pro Ser Phe Gly Lys Leu Asn Ser Leu Lys Ser Ile Asp 
                165                 170                 175     


Phe Ser Ser Asn Gln Ile Phe Leu Val Cys Glu His Glu Leu Glu Pro 
            180                 185                 190         


Leu Gln Gly Lys Thr Leu Ser Phe Phe Ser Leu Ala Ala Asn Ser Leu 
        195                 200                 205             


Tyr Ser Arg Val Ser Val Asp Trp Gly Lys Cys Met Asn Pro Phe Arg 
    210                 215                 220                 


Asn Met Val Leu Glu Ile Leu Asp Val Ser Gly Asn Gly Trp Thr Val 
225                 230                 235                 240 


Asp Ile Thr Gly Asn Phe Ser Asn Ala Ile Ser Lys Ser Gln Ala Phe 
                245                 250                 255     


Ser Leu Ile Leu Ala His His Ile Met Gly Ala Gly Phe Gly Phe His 
            260                 265                 270         


Asn Ile Lys Asp Pro Asp Gln Asn Thr Phe Ala Gly Leu Ala Arg Ser 
        275                 280                 285             


Ser Val Arg His Leu Asp Leu Ser His Gly Phe Val Phe Ser Leu Asn 
    290                 295                 300                 


Ser Arg Val Phe Glu Thr Leu Lys Asp Leu Lys Val Leu Asn Leu Ala 
305                 310                 315                 320 


Tyr Asn Lys Ile Asn Lys Ile Ala Asp Glu Ala Phe Tyr Gly Leu Asp 
                325                 330                 335     


Asn Leu Gln Val Leu Asn Leu Ser Tyr Asn Leu Leu Gly Glu Leu Tyr 
            340                 345                 350         


Ser Ser Asn Phe Tyr Gly Leu Pro Lys Val Ala Tyr Ile Asp Leu Gln 
        355                 360                 365             


Lys Asn His Ile Ala Ile Ile Gln Asp Gln Thr Phe Lys Phe Leu Glu 
    370                 375                 380                 


Lys Leu Gln Thr Leu Asp Leu Arg Asp Asn Ala Leu Thr Thr Ile His 
385                 390                 395                 400 


Phe Ile Pro Ser Ile Pro Asp Ile Phe Leu Ser Gly Asn Lys Leu Val 
                405                 410                 415     


Thr Leu Pro Lys Ile Asn Leu Thr Ala Asn Leu Ile His Leu Ser Glu 
            420                 425                 430         


Asn Arg Leu Glu Asn Leu Asp Ile Leu Tyr Phe Leu Leu Arg Val Pro 
        435                 440                 445             


His Leu Gln Ile Leu Ile Leu Asn Gln Asn Arg Phe Ser Ser Cys Ser 
    450                 455                 460                 


Gly Asp Gln Thr Pro Ser Glu Asn Pro Ser Leu Glu Gln Leu Phe Leu 
465                 470                 475                 480 


Gly Glu Asn Met Leu Gln Leu Ala Trp Glu Thr Glu Leu Cys Trp Asp 
                485                 490                 495     


Val Phe Glu Gly Leu Ser His Leu Gln Val Leu Tyr Leu Asn His Asn 
            500                 505                 510         


Tyr Leu Asn Ser Leu Pro Pro Gly Val Phe Ser His Leu Thr Ala Leu 
        515                 520                 525             


Arg Gly Leu Ser Leu Asn Ser Asn Arg Leu Thr Val Leu Ser His Asn 
    530                 535                 540                 


Asp Leu Pro Ala Asn Leu Glu Ile Leu Asp Ile Ser Arg Asn Gln Leu 
545                 550                 555                 560 


Leu Ala Pro Asn Pro Asp Val Phe Val Ser Leu Ser Val Leu Asp Ile 
                565                 570                 575     


Thr His Asn Lys Phe Ile Cys Glu Cys Glu Leu Ser Thr Phe Ile Asn 
            580                 585                 590         


Trp Leu Asn His Thr Asn Val Thr Ile Ala Gly Pro Pro Ala Asp Ile 
        595                 600                 605             


Tyr Cys Val Tyr Pro Asp Ser Phe Ser Gly Val Ser Leu Phe Ser Leu 
    610                 615                 620                 


Ser Thr Glu Gly Cys Asp Glu Glu Glu Val Leu Lys Ser Leu Lys Phe 
625                 630                 635                 640 


Ser Leu Phe Ile Val Cys Thr Val Thr Leu Thr Leu Phe Leu Met Thr 
                645                 650                 655     


Ile Leu Thr Val Thr Lys Phe Arg Gly Phe Cys Phe Ile Cys Tyr Lys 
            660                 665                 670         


Thr Ala Gln Arg Leu Val Phe Lys Asp His Pro Gln Gly Thr Glu Pro 
        675                 680                 685             


Asp Met Tyr Lys Tyr Asp Ala Tyr Leu Cys Phe Ser Ser Lys Asp Phe 
    690                 695                 700                 


Thr Trp Val Gln Asn Ala Leu Leu Lys His Leu Asp Thr Gln Tyr Ser 
705                 710                 715                 720 


Asp Gln Asn Arg Phe Asn Leu Cys Phe Glu Glu Arg Asp Phe Val Pro 
                725                 730                 735     


Gly Glu Asn Arg Ile Ala Asn Ile Gln Asp Ala Ile Trp Asn Ser Arg 
            740                 745                 750         


Lys Ile Val Cys Leu Val Ser Arg His Phe Leu Arg Asp Gly Trp Cys 
        755                 760                 765             


Leu Glu Ala Phe Ser Tyr Ala Gln Gly Arg Cys Leu Ser Asp Leu Asn 
    770                 775                 780                 


Ser Ala Leu Ile Met Val Val Val Gly Ser Leu Ser Gln Tyr Gln Leu 
785                 790                 795                 800 


Met Lys His Gln Ser Ile Arg Gly Phe Val Gln Lys Gln Gln Tyr Leu 
                805                 810                 815     


Arg Trp Pro Glu Asp Leu Gln Asp Val Gly Trp Phe Leu His Lys Leu 
            820                 825                 830         


Ser Gln Gln Ile Leu Lys Lys Glu Lys Glu Lys Lys Lys Asp Asn Asn 
        835                 840                 845             


Ile Pro Leu Gln Thr Val Ala Thr Ile Ser 
    850                 855             


<210>  32
<211>  839
<212>  PRT
<213>  artificial

<220>
<223>  Homo sapiens TLR4

<400>  32

Met Met Ser Ala Ser Arg Leu Ala Gly Thr Leu Ile Pro Ala Met Ala 
1               5                   10                  15      


Phe Leu Ser Cys Val Arg Pro Glu Ser Trp Glu Pro Cys Val Glu Val 
            20                  25                  30          


Val Pro Asn Ile Thr Tyr Gln Cys Met Glu Leu Asn Phe Tyr Lys Ile 
        35                  40                  45              


Pro Asp Asn Leu Pro Phe Ser Thr Lys Asn Leu Asp Leu Ser Phe Asn 
    50                  55                  60                  


Pro Leu Arg His Leu Gly Ser Tyr Ser Phe Phe Ser Phe Pro Glu Leu 
65                  70                  75                  80  


Gln Val Leu Asp Leu Ser Arg Cys Glu Ile Gln Thr Ile Glu Asp Gly 
                85                  90                  95      


Ala Tyr Gln Ser Leu Ser His Leu Ser Thr Leu Ile Leu Thr Gly Asn 
            100                 105                 110         


Pro Ile Gln Ser Leu Ala Leu Gly Ala Phe Ser Gly Leu Ser Ser Leu 
        115                 120                 125             


Gln Lys Leu Val Ala Val Glu Thr Asn Leu Ala Ser Leu Glu Asn Phe 
    130                 135                 140                 


Pro Ile Gly His Leu Lys Thr Leu Lys Glu Leu Asn Val Ala His Asn 
145                 150                 155                 160 


Leu Ile Gln Ser Phe Lys Leu Pro Glu Tyr Phe Ser Asn Leu Thr Asn 
                165                 170                 175     


Leu Glu His Leu Asp Leu Ser Ser Asn Lys Ile Gln Ser Ile Tyr Cys 
            180                 185                 190         


Thr Asp Leu Arg Val Leu His Gln Met Pro Leu Leu Asn Leu Ser Leu 
        195                 200                 205             


Asp Leu Ser Leu Asn Pro Met Asn Phe Ile Gln Pro Gly Ala Phe Lys 
    210                 215                 220                 


Glu Ile Arg Leu His Lys Leu Thr Leu Arg Asn Asn Phe Asp Ser Leu 
225                 230                 235                 240 


Asn Val Met Lys Thr Cys Ile Gln Gly Leu Ala Gly Leu Glu Val His 
                245                 250                 255     


Arg Leu Val Leu Gly Glu Phe Arg Asn Glu Gly Asn Leu Glu Lys Phe 
            260                 265                 270         


Asp Lys Ser Ala Leu Glu Gly Leu Cys Asn Leu Thr Ile Glu Glu Phe 
        275                 280                 285             


Arg Leu Ala Tyr Leu Asp Tyr Tyr Leu Asp Asp Ile Ile Asp Leu Phe 
    290                 295                 300                 


Asn Cys Leu Thr Asn Val Ser Ser Phe Ser Leu Val Ser Val Thr Ile 
305                 310                 315                 320 


Glu Arg Val Lys Asp Phe Ser Tyr Asn Phe Gly Trp Gln His Leu Glu 
                325                 330                 335     


Leu Val Asn Cys Lys Phe Gly Gln Phe Pro Thr Leu Lys Leu Lys Ser 
            340                 345                 350         


Leu Lys Arg Leu Thr Phe Thr Ser Asn Lys Gly Gly Asn Ala Phe Ser 
        355                 360                 365             


Glu Val Asp Leu Pro Ser Leu Glu Phe Leu Asp Leu Ser Arg Asn Gly 
    370                 375                 380                 


Leu Ser Phe Lys Gly Cys Cys Ser Gln Ser Asp Phe Gly Thr Thr Ser 
385                 390                 395                 400 


Leu Lys Tyr Leu Asp Leu Ser Phe Asn Gly Val Ile Thr Met Ser Ser 
                405                 410                 415     


Asn Phe Leu Gly Leu Glu Gln Leu Glu His Leu Asp Phe Gln His Ser 
            420                 425                 430         


Asn Leu Lys Gln Met Ser Glu Phe Ser Val Phe Leu Ser Leu Arg Asn 
        435                 440                 445             


Leu Ile Tyr Leu Asp Ile Ser His Thr His Thr Arg Val Ala Phe Asn 
    450                 455                 460                 


Gly Ile Phe Asn Gly Leu Ser Ser Leu Glu Val Leu Lys Met Ala Gly 
465                 470                 475                 480 


Asn Ser Phe Gln Glu Asn Phe Leu Pro Asp Ile Phe Thr Glu Leu Arg 
                485                 490                 495     


Asn Leu Thr Phe Leu Asp Leu Ser Gln Cys Gln Leu Glu Gln Leu Ser 
            500                 505                 510         


Pro Thr Ala Phe Asn Ser Leu Ser Ser Leu Gln Val Leu Asn Met Ser 
        515                 520                 525             


His Asn Asn Phe Phe Ser Leu Asp Thr Phe Pro Tyr Lys Cys Leu Asn 
    530                 535                 540                 


Ser Leu Gln Val Leu Asp Tyr Ser Leu Asn His Ile Met Thr Ser Lys 
545                 550                 555                 560 


Lys Gln Glu Leu Gln His Phe Pro Ser Ser Leu Ala Phe Leu Asn Leu 
                565                 570                 575     


Thr Gln Asn Asp Phe Ala Cys Thr Cys Glu His Gln Ser Phe Leu Gln 
            580                 585                 590         


Trp Ile Lys Asp Gln Arg Gln Leu Leu Val Glu Val Glu Arg Met Glu 
        595                 600                 605             


Cys Ala Thr Pro Ser Asp Lys Gln Gly Met Pro Val Leu Ser Leu Asn 
    610                 615                 620                 


Ile Thr Cys Gln Met Asn Lys Thr Ile Ile Gly Val Ser Val Leu Ser 
625                 630                 635                 640 


Val Leu Val Val Ser Val Val Ala Val Leu Val Tyr Lys Phe Tyr Phe 
                645                 650                 655     


His Leu Met Leu Leu Ala Gly Cys Ile Lys Tyr Gly Arg Gly Glu Asn 
            660                 665                 670         


Ile Tyr Asp Ala Phe Val Ile Tyr Ser Ser Gln Asp Glu Asp Trp Val 
        675                 680                 685             


Arg Asn Glu Leu Val Lys Asn Leu Glu Glu Gly Val Pro Pro Phe Gln 
    690                 695                 700                 


Leu Cys Leu His Tyr Arg Asp Phe Ile Pro Gly Val Ala Ile Ala Ala 
705                 710                 715                 720 


Asn Ile Ile His Glu Gly Phe His Lys Ser Arg Lys Val Ile Val Val 
                725                 730                 735     


Val Ser Gln His Phe Ile Gln Ser Arg Trp Cys Ile Phe Glu Tyr Glu 
            740                 745                 750         


Ile Ala Gln Thr Trp Gln Phe Leu Ser Ser Arg Ala Gly Ile Ile Phe 
        755                 760                 765             


Ile Val Leu Gln Lys Val Glu Lys Thr Leu Leu Arg Gln Gln Val Glu 
    770                 775                 780                 


Leu Tyr Arg Leu Leu Ser Arg Asn Thr Tyr Leu Glu Trp Glu Asp Ser 
785                 790                 795                 800 


Val Leu Gly Arg His Ile Phe Trp Arg Arg Leu Arg Lys Ala Leu Leu 
                805                 810                 815     


Asp Gly Lys Ser Trp Asn Pro Glu Gly Thr Val Gly Thr Gly Cys Asn 
            820                 825                 830         


Trp Gln Glu Ala Thr Ser Ile 
        835                 


<210>  33
<211>  784
<212>  PRT
<213>  artificial

<220>
<223>  Homo sapiens TLR2

<400>  33

Met Pro His Thr Leu Trp Met Val Trp Val Leu Gly Val Ile Ile Ser 
1               5                   10                  15      


Leu Ser Lys Glu Glu Ser Ser Asn Gln Ala Ser Leu Ser Cys Asp Arg 
            20                  25                  30          


Asn Gly Ile Cys Lys Gly Ser Ser Gly Ser Leu Asn Ser Ile Pro Ser 
        35                  40                  45              


Gly Leu Thr Glu Ala Val Lys Ser Leu Asp Leu Ser Asn Asn Arg Ile 
    50                  55                  60                  


Thr Tyr Ile Ser Asn Ser Asp Leu Gln Arg Cys Val Asn Leu Gln Ala 
65                  70                  75                  80  


Leu Val Leu Thr Ser Asn Gly Ile Asn Thr Ile Glu Glu Asp Ser Phe 
                85                  90                  95      


Ser Ser Leu Gly Ser Leu Glu His Leu Asp Leu Ser Tyr Asn Tyr Leu 
            100                 105                 110         


Ser Asn Leu Ser Ser Ser Trp Phe Lys Pro Leu Ser Ser Leu Thr Phe 
        115                 120                 125             


Leu Asn Leu Leu Gly Asn Pro Tyr Lys Thr Leu Gly Glu Thr Ser Leu 
    130                 135                 140                 


Phe Ser His Leu Thr Lys Leu Gln Ile Leu Arg Val Gly Asn Met Asp 
145                 150                 155                 160 


Thr Phe Thr Lys Ile Gln Arg Lys Asp Phe Ala Gly Leu Thr Phe Leu 
                165                 170                 175     


Glu Glu Leu Glu Ile Asp Ala Ser Asp Leu Gln Ser Tyr Glu Pro Lys 
            180                 185                 190         


Ser Leu Lys Ser Ile Gln Asn Val Ser His Leu Ile Leu His Met Lys 
        195                 200                 205             


Gln His Ile Leu Leu Leu Glu Ile Phe Val Asp Val Thr Ser Ser Val 
    210                 215                 220                 


Glu Cys Leu Glu Leu Arg Asp Thr Asp Leu Asp Thr Phe His Phe Ser 
225                 230                 235                 240 


Glu Leu Ser Thr Gly Glu Thr Asn Ser Leu Ile Lys Lys Phe Thr Phe 
                245                 250                 255     


Arg Asn Val Lys Ile Thr Asp Glu Ser Leu Phe Gln Val Met Lys Leu 
            260                 265                 270         


Leu Asn Gln Ile Ser Gly Leu Leu Glu Leu Glu Phe Asp Asp Cys Thr 
        275                 280                 285             


Leu Asn Gly Val Gly Asn Phe Arg Ala Ser Asp Asn Asp Arg Val Ile 
    290                 295                 300                 


Asp Pro Gly Lys Val Glu Thr Leu Thr Ile Arg Arg Leu His Ile Pro 
305                 310                 315                 320 


Arg Phe Tyr Leu Phe Tyr Asp Leu Ser Thr Leu Tyr Ser Leu Thr Glu 
                325                 330                 335     


Arg Val Lys Arg Ile Thr Val Glu Asn Ser Lys Val Phe Leu Val Pro 
            340                 345                 350         


Cys Leu Leu Ser Gln His Leu Lys Ser Leu Glu Tyr Leu Asp Leu Ser 
        355                 360                 365             


Glu Asn Leu Met Val Glu Glu Tyr Leu Lys Asn Ser Ala Cys Glu Asp 
    370                 375                 380                 


Ala Trp Pro Ser Leu Gln Thr Leu Ile Leu Arg Gln Asn His Leu Ala 
385                 390                 395                 400 


Ser Leu Glu Lys Thr Gly Glu Thr Leu Leu Thr Leu Lys Asn Leu Thr 
                405                 410                 415     


Asn Ile Asp Ile Ser Lys Asn Ser Phe His Ser Met Pro Glu Thr Cys 
            420                 425                 430         


Gln Trp Pro Glu Lys Met Lys Tyr Leu Asn Leu Ser Ser Thr Arg Ile 
        435                 440                 445             


His Ser Val Thr Gly Cys Ile Pro Lys Thr Leu Glu Ile Leu Asp Val 
    450                 455                 460                 


Ser Asn Asn Asn Leu Asn Leu Phe Ser Leu Asn Leu Pro Gln Leu Lys 
465                 470                 475                 480 


Glu Leu Tyr Ile Ser Arg Asn Lys Leu Met Thr Leu Pro Asp Ala Ser 
                485                 490                 495     


Leu Leu Pro Met Leu Leu Val Leu Lys Ile Ser Arg Asn Ala Ile Thr 
            500                 505                 510         


Thr Phe Ser Lys Glu Gln Leu Asp Ser Phe His Thr Leu Lys Thr Leu 
        515                 520                 525             


Glu Ala Gly Gly Asn Asn Phe Ile Cys Ser Cys Glu Phe Leu Ser Phe 
    530                 535                 540                 


Thr Gln Glu Gln Gln Ala Leu Ala Lys Val Leu Ile Asp Trp Pro Ala 
545                 550                 555                 560 


Asn Tyr Leu Cys Asp Ser Pro Ser His Val Arg Gly Gln Gln Val Gln 
                565                 570                 575     


Asp Val Arg Leu Ser Val Ser Glu Cys His Arg Thr Ala Leu Val Ser 
            580                 585                 590         


Gly Met Cys Cys Ala Leu Phe Leu Leu Ile Leu Leu Thr Gly Val Leu 
        595                 600                 605             


Cys His Arg Phe His Gly Leu Trp Tyr Met Lys Met Met Trp Ala Trp 
    610                 615                 620                 


Leu Gln Ala Lys Arg Lys Pro Arg Lys Ala Pro Ser Arg Asn Ile Cys 
625                 630                 635                 640 


Tyr Asp Ala Phe Val Ser Tyr Ser Glu Arg Asp Ala Tyr Trp Val Glu 
                645                 650                 655     


Asn Leu Met Val Gln Glu Leu Glu Asn Phe Asn Pro Pro Phe Lys Leu 
            660                 665                 670         


Cys Leu His Lys Arg Asp Phe Ile Pro Gly Lys Trp Ile Ile Asp Asn 
        675                 680                 685             


Ile Ile Asp Ser Ile Glu Lys Ser His Lys Thr Val Phe Val Leu Ser 
    690                 695                 700                 


Glu Asn Phe Val Lys Ser Glu Trp Cys Lys Tyr Glu Leu Asp Phe Ser 
705                 710                 715                 720 


His Phe Arg Leu Phe Asp Glu Asn Asn Asp Ala Ala Ile Leu Ile Leu 
                725                 730                 735     


Leu Glu Pro Ile Glu Lys Lys Ala Ile Pro Gln Arg Phe Cys Lys Leu 
            740                 745                 750         


Arg Lys Ile Met Asn Thr Lys Thr Tyr Leu Glu Trp Pro Met Asp Glu 
        755                 760                 765             


Ala Gln Arg Glu Gly Phe Trp Val Asn Leu Arg Ala Ala Ile Lys Ser 
    770                 775                 780                 


<210>  34
<211>  811
<212>  PRT
<213>  artificial

<220>
<223>  Homo sapiens TLR10

<400>  34

Met Arg Leu Ile Arg Asn Ile Tyr Ile Phe Cys Ser Ile Val Met Thr 
1               5                   10                  15      


Ala Glu Gly Asp Ala Pro Glu Leu Pro Glu Glu Arg Glu Leu Met Thr 
            20                  25                  30          


Asn Cys Ser Asn Met Ser Leu Arg Lys Val Pro Ala Asp Leu Thr Pro 
        35                  40                  45              


Ala Thr Thr Thr Leu Asp Leu Ser Tyr Asn Leu Leu Phe Gln Leu Gln 
    50                  55                  60                  


Ser Ser Asp Phe His Ser Val Ser Lys Leu Arg Val Leu Ile Leu Cys 
65                  70                  75                  80  


His Asn Arg Ile Gln Gln Leu Asp Leu Lys Thr Phe Glu Phe Asn Lys 
                85                  90                  95      


Glu Leu Arg Tyr Leu Asp Leu Ser Asn Asn Arg Leu Lys Ser Val Thr 
            100                 105                 110         


Trp Tyr Leu Leu Ala Gly Leu Arg Tyr Leu Asp Leu Ser Phe Asn Asp 
        115                 120                 125             


Phe Asp Thr Met Pro Ile Cys Glu Glu Ala Gly Asn Met Ser His Leu 
    130                 135                 140                 


Glu Ile Leu Gly Leu Ser Gly Ala Lys Ile Gln Lys Ser Asp Phe Gln 
145                 150                 155                 160 


Lys Ile Ala His Leu His Leu Asn Thr Val Phe Leu Gly Phe Arg Thr 
                165                 170                 175     


Leu Pro His Tyr Glu Glu Gly Ser Leu Pro Ile Leu Asn Thr Thr Lys 
            180                 185                 190         


Leu His Ile Val Leu Pro Met Asp Thr Asn Phe Trp Val Leu Leu Arg 
        195                 200                 205             


Asp Gly Ile Lys Thr Ser Lys Ile Leu Glu Met Thr Asn Ile Asp Gly 
    210                 215                 220                 


Lys Ser Gln Phe Val Ser Tyr Glu Met Gln Arg Asn Leu Ser Leu Glu 
225                 230                 235                 240 


His Ala Lys Thr Ser Val Leu Leu Leu Asn Lys Val Asp Leu Leu Trp 
                245                 250                 255     


Asp Asp Leu Phe Leu Ile Leu Gln Phe Val Trp His Thr Ser Val Glu 
            260                 265                 270         


His Phe Gln Ile Arg Asn Val Thr Phe Gly Gly Lys Ala Tyr Leu Asp 
        275                 280                 285             


His Asn Ser Phe Asp Tyr Ser Asn Thr Val Met Arg Thr Ile Lys Leu 
    290                 295                 300                 


Glu His Val His Phe Arg Val Phe Tyr Ile Gln Gln Asp Lys Ile Tyr 
305                 310                 315                 320 


Leu Leu Leu Thr Lys Met Asp Ile Glu Asn Leu Thr Ile Ser Asn Ala 
                325                 330                 335     


Gln Met Pro His Met Leu Phe Pro Asn Tyr Pro Thr Lys Phe Gln Tyr 
            340                 345                 350         


Leu Asn Phe Ala Asn Asn Ile Leu Thr Asp Glu Leu Phe Lys Arg Thr 
        355                 360                 365             


Leu Gln Leu Pro His Leu Lys Thr Leu Ile Leu Asn Gly Asn Lys Leu 
    370                 375                 380                 


Glu Thr Leu Ser Leu Val Ser Cys Phe Ala Asn Asn Thr Pro Leu Glu 
385                 390                 395                 400 


His Leu Asp Leu Ser Gln Asn Leu Leu Gln His Lys Asn Asp Glu Asn 
                405                 410                 415     


Cys Ser Trp Pro Glu Thr Val Val Asn Met Asn Leu Ser Tyr Asn Lys 
            420                 425                 430         


Leu Ser Asp Ser Val Phe Arg Cys Leu Pro Lys Ser Ile Gln Ile Leu 
        435                 440                 445             


Asp Leu Asn Asn Asn Gln Ile Gln Thr Val Pro Lys Glu Thr Ile His 
    450                 455                 460                 


Leu Met Ala Leu Arg Glu Leu Asn Ile Ala Phe Asn Phe Leu Thr Asp 
465                 470                 475                 480 


Leu Pro Gly Cys Ser His Phe Ser Arg Leu Ser Val Leu Asn Ile Glu 
                485                 490                 495     


Met Asn Phe Ile Leu Ser Pro Ser Leu Asp Phe Val Gln Ser Cys Gln 
            500                 505                 510         


Glu Val Lys Thr Leu Asn Ala Gly Arg Asn Pro Phe Arg Cys Thr Cys 
        515                 520                 525             


Glu Leu Lys Asn Phe Ile Gln Leu Glu Thr Tyr Ser Glu Val Met Met 
    530                 535                 540                 


Val Gly Trp Ser Asp Ser Tyr Thr Cys Glu Tyr Pro Leu Asn Leu Arg 
545                 550                 555                 560 


Gly Thr Arg Leu Lys Asp Val His Leu His Glu Leu Ser Cys Asn Thr 
                565                 570                 575     


Ala Leu Leu Ile Val Thr Ile Val Val Ile Met Leu Val Leu Gly Leu 
            580                 585                 590         


Ala Val Ala Phe Cys Cys Leu His Phe Asp Leu Pro Trp Tyr Leu Arg 
        595                 600                 605             


Met Leu Gly Gln Cys Thr Gln Thr Trp His Arg Val Arg Lys Thr Thr 
    610                 615                 620                 


Gln Glu Gln Leu Lys Arg Asn Val Arg Phe His Ala Phe Ile Ser Tyr 
625                 630                 635                 640 


Ser Glu His Asp Ser Leu Trp Val Lys Asn Glu Leu Ile Pro Asn Leu 
                645                 650                 655     


Glu Lys Glu Asp Gly Ser Ile Leu Ile Cys Leu Tyr Glu Ser Tyr Phe 
            660                 665                 670         


Asp Pro Gly Lys Ser Ile Ser Glu Asn Ile Val Ser Phe Ile Glu Lys 
        675                 680                 685             


Ser Tyr Lys Ser Ile Phe Val Leu Ser Pro Asn Phe Val Gln Asn Glu 
    690                 695                 700                 


Trp Cys His Tyr Glu Phe Tyr Phe Ala His His Asn Leu Phe His Glu 
705                 710                 715                 720 


Asn Ser Asp His Ile Ile Leu Ile Leu Leu Glu Pro Ile Pro Phe Tyr 
                725                 730                 735     


Cys Ile Pro Thr Arg Tyr His Lys Leu Lys Ala Leu Leu Glu Lys Lys 
            740                 745                 750         


Ala Tyr Leu Glu Trp Pro Lys Asp Arg Arg Lys Cys Gly Leu Phe Trp 
        755                 760                 765             


Ala Asn Leu Arg Ala Ala Ile Asn Val Asn Val Leu Ala Thr Arg Glu 
    770                 775                 780                 


Met Tyr Glu Leu Gln Thr Phe Thr Glu Leu Asn Glu Glu Ser Arg Gly 
785                 790                 795                 800 


Ser Thr Ile Ser Leu Met Arg Thr Asp Cys Leu 
                805                 810     


<210>  35
<211>  786
<212>  PRT
<213>  artificial

<220>
<223>  Homo sapiens TLR1

<400>  35

Met Thr Ser Ile Phe His Phe Ala Ile Ile Phe Met Leu Ile Leu Gln 
1               5                   10                  15      


Ile Arg Ile Gln Leu Ser Glu Glu Ser Glu Phe Leu Val Asp Arg Ser 
            20                  25                  30          


Lys Asn Gly Leu Ile His Val Pro Lys Asp Leu Ser Gln Lys Thr Thr 
        35                  40                  45              


Ile Leu Asn Ile Ser Gln Asn Tyr Ile Ser Glu Leu Trp Thr Ser Asp 
    50                  55                  60                  


Ile Leu Ser Leu Ser Lys Leu Arg Ile Leu Ile Ile Ser His Asn Arg 
65                  70                  75                  80  


Ile Gln Tyr Leu Asp Ile Ser Val Phe Lys Phe Asn Gln Glu Leu Glu 
                85                  90                  95      


Tyr Leu Asp Leu Ser His Asn Lys Leu Val Lys Ile Ser Cys His Pro 
            100                 105                 110         


Thr Val Asn Leu Lys His Leu Asp Leu Ser Phe Asn Ala Phe Asp Ala 
        115                 120                 125             


Leu Pro Ile Cys Lys Glu Phe Gly Asn Met Ser Gln Leu Lys Phe Leu 
    130                 135                 140                 


Gly Leu Ser Thr Thr His Leu Glu Lys Ser Ser Val Leu Pro Ile Ala 
145                 150                 155                 160 


His Leu Asn Ile Ser Lys Val Leu Leu Val Leu Gly Glu Thr Tyr Gly 
                165                 170                 175     


Glu Lys Glu Asp Pro Gly Gly Leu Gln Asp Phe Asn Thr Glu Ser Leu 
            180                 185                 190         


His Ile Val Phe Pro Thr Asn Lys Glu Phe His Phe Ile Leu Asp Val 
        195                 200                 205             


Ser Val Lys Thr Val Ala Asn Leu Glu Leu Ser Asn Ile Lys Cys Val 
    210                 215                 220                 


Leu Glu Asp Ser Lys Cys Ser Tyr Phe Leu Ser Ile Leu Ala Lys Leu 
225                 230                 235                 240 


Gln Thr Asn Pro Lys Leu Ser Ser Leu Thr Leu Asn Asn Ile Glu Thr 
                245                 250                 255     


Thr Trp Asn Ser Phe Ile Arg Ile Leu Gln Leu Val Trp His Thr Thr 
            260                 265                 270         


Val Trp Tyr Ser Ser Ile Ser Asn Val Lys Leu Gln Gly Gln Leu Asp 
        275                 280                 285             


Phe Arg Asp Phe Asp Tyr Ser Gly Thr Ser Leu Lys Ala Leu Ser Ile 
    290                 295                 300                 


His Gln Val Val Ser Asp Val Phe Gly Phe Pro Gln Ser Tyr Ile Tyr 
305                 310                 315                 320 


Glu Ile Phe Ser Asn Met Asn Ile Lys Asn Phe Thr Val Ser Gly Thr 
                325                 330                 335     


Arg Met Val His Met Leu Cys Pro Ser Lys Ile Ser Pro Phe Leu His 
            340                 345                 350         


Leu Asp Phe Ser Asn Asn Leu Leu Thr Asp Thr Val Phe Glu Asn Cys 
        355                 360                 365             


Gly His Leu Thr Glu Leu Glu Thr Leu Ile Leu Gln Met Asn Gln Leu 
    370                 375                 380                 


Lys Glu Leu Ser Lys Ile Ala Glu Met Thr Thr Gln Met Lys Ser Leu 
385                 390                 395                 400 


Gln Gln Leu Asp Ile Ser Gln Asn Ser Val Ser Tyr Asp Glu Lys Lys 
                405                 410                 415     


Gly Asp Cys Ser Trp Thr Lys Ser Leu Leu Ser Leu Asn Met Ser Ser 
            420                 425                 430         


Asn Ile Leu Thr Asp Thr Ile Phe Arg Cys Leu Pro Pro Arg Ile Lys 
        435                 440                 445             


Val Leu Asp Leu His Ser Asn Lys Ile Lys Ser Ile Pro Lys Gln Val 
    450                 455                 460                 


Val Lys Leu Glu Ala Leu Gln Glu Leu Asn Val Ala Phe Asn Ser Leu 
465                 470                 475                 480 


Thr Asp Leu Pro Gly Cys Gly Ser Phe Ser Ser Leu Ser Val Leu Ile 
                485                 490                 495     


Ile Asp His Asn Ser Val Ser His Pro Ser Ala Asp Phe Phe Gln Ser 
            500                 505                 510         


Cys Gln Lys Met Arg Ser Ile Lys Ala Gly Asp Asn Pro Phe Gln Cys 
        515                 520                 525             


Thr Cys Glu Leu Gly Glu Phe Val Lys Asn Ile Asp Gln Val Ser Ser 
    530                 535                 540                 


Glu Val Leu Glu Gly Trp Pro Asp Ser Tyr Lys Cys Asp Tyr Pro Glu 
545                 550                 555                 560 


Ser Tyr Arg Gly Thr Leu Leu Lys Asp Phe His Met Ser Glu Leu Ser 
                565                 570                 575     


Cys Asn Ile Thr Leu Leu Ile Val Thr Ile Val Ala Thr Met Leu Val 
            580                 585                 590         


Leu Ala Val Thr Val Thr Ser Leu Cys Ile Tyr Leu Asp Leu Pro Trp 
        595                 600                 605             


Tyr Leu Arg Met Val Cys Gln Trp Thr Gln Thr Arg Arg Arg Ala Arg 
    610                 615                 620                 


Asn Ile Pro Leu Glu Glu Leu Gln Arg Asn Leu Gln Phe His Ala Phe 
625                 630                 635                 640 


Ile Ser Tyr Ser Gly His Asp Ser Phe Trp Met Lys Asn Glu Leu Leu 
                645                 650                 655     


Pro Asn Leu Glu Lys Glu Gly Met Gln Ile Cys Leu His Glu Arg Asn 
            660                 665                 670         


Phe Val Pro Gly Lys Ser Ile Val Glu Asn Ile Ile Thr Cys Ile Glu 
        675                 680                 685             


Lys Ser Tyr Lys Ser Ile Phe Val Leu Ser Pro Asn Phe Val Gln Ser 
    690                 695                 700                 


Glu Trp Cys His Tyr Glu Leu Tyr Phe Ala His His Asn Leu Phe His 
705                 710                 715                 720 


Glu Gly Ser Asn Ser Leu Ile Leu Ile Leu Leu Glu Pro Ile Pro Gln 
                725                 730                 735     


Tyr Ser Ile Pro Ser Ser Tyr His Lys Leu Lys Ser Leu Met Ala Arg 
            740                 745                 750         


Arg Thr Tyr Leu Glu Trp Pro Lys Glu Lys Ser Lys Arg Gly Leu Phe 
        755                 760                 765             


Trp Ala Asn Leu Arg Ala Ala Ile Asn Ile Lys Leu Thr Glu Gln Ala 
    770                 775                 780                 


Lys Lys 
785     


<210>  36
<211>  796
<212>  PRT
<213>  artificial

<220>
<223>  Homo sapiens TLR6

<400>  36

Met Thr Lys Asp Lys Glu Pro Ile Val Lys Ser Phe His Phe Val Cys 
1               5                   10                  15      


Leu Met Ile Ile Ile Val Gly Thr Arg Ile Gln Phe Ser Asp Gly Asn 
            20                  25                  30          


Glu Phe Ala Val Asp Lys Ser Lys Arg Gly Leu Ile His Val Pro Lys 
        35                  40                  45              


Asp Leu Pro Leu Lys Thr Lys Val Leu Asp Met Ser Gln Asn Tyr Ile 
    50                  55                  60                  


Ala Glu Leu Gln Val Ser Asp Met Ser Phe Leu Ser Glu Leu Thr Val 
65                  70                  75                  80  


Leu Arg Leu Ser His Asn Arg Ile Gln Leu Leu Asp Leu Ser Val Phe 
                85                  90                  95      


Lys Phe Asn Gln Asp Leu Glu Tyr Leu Asp Leu Ser His Asn Gln Leu 
            100                 105                 110         


Gln Lys Ile Ser Cys His Pro Ile Val Ser Phe Arg His Leu Asp Leu 
        115                 120                 125             


Ser Phe Asn Asp Phe Lys Ala Leu Pro Ile Cys Lys Glu Phe Gly Asn 
    130                 135                 140                 


Leu Ser Gln Leu Asn Phe Leu Gly Leu Ser Ala Met Lys Leu Gln Lys 
145                 150                 155                 160 


Leu Asp Leu Leu Pro Ile Ala His Leu His Leu Ser Tyr Ile Leu Leu 
                165                 170                 175     


Asp Leu Arg Asn Tyr Tyr Ile Lys Glu Asn Glu Thr Glu Ser Leu Gln 
            180                 185                 190         


Ile Leu Asn Ala Lys Thr Leu His Leu Val Phe His Pro Thr Ser Leu 
        195                 200                 205             


Phe Ala Ile Gln Val Asn Ile Ser Val Asn Thr Leu Gly Cys Leu Gln 
    210                 215                 220                 


Leu Thr Asn Ile Lys Leu Asn Asp Asp Asn Cys Gln Val Phe Ile Lys 
225                 230                 235                 240 


Phe Leu Ser Glu Leu Thr Arg Gly Pro Thr Leu Leu Asn Phe Thr Leu 
                245                 250                 255     


Asn His Ile Glu Thr Thr Trp Lys Cys Leu Val Arg Val Phe Gln Phe 
            260                 265                 270         


Leu Trp Pro Lys Pro Val Glu Tyr Leu Asn Ile Tyr Asn Leu Thr Ile 
        275                 280                 285             


Ile Glu Ser Ile Arg Glu Glu Asp Phe Thr Tyr Ser Lys Thr Thr Leu 
    290                 295                 300                 


Lys Ala Leu Thr Ile Glu His Ile Thr Asn Gln Val Phe Leu Phe Ser 
305                 310                 315                 320 


Gln Thr Ala Leu Tyr Thr Val Phe Ser Glu Met Asn Ile Met Met Leu 
                325                 330                 335     


Thr Ile Ser Asp Thr Pro Phe Ile His Met Leu Cys Pro His Ala Pro 
            340                 345                 350         


Ser Thr Phe Lys Phe Leu Asn Phe Thr Gln Asn Val Phe Thr Asp Ser 
        355                 360                 365             


Ile Phe Glu Lys Cys Ser Thr Leu Val Lys Leu Glu Thr Leu Ile Leu 
    370                 375                 380                 


Gln Lys Asn Gly Leu Lys Asp Leu Phe Lys Val Gly Leu Met Thr Lys 
385                 390                 395                 400 


Asp Met Pro Ser Leu Glu Ile Leu Asp Val Ser Trp Asn Ser Leu Glu 
                405                 410                 415     


Ser Gly Arg His Lys Glu Asn Cys Thr Trp Val Glu Ser Ile Val Val 
            420                 425                 430         


Leu Asn Leu Ser Ser Asn Met Leu Thr Asp Ser Val Phe Arg Cys Leu 
        435                 440                 445             


Pro Pro Arg Ile Lys Val Leu Asp Leu His Ser Asn Lys Ile Lys Ser 
    450                 455                 460                 


Val Pro Lys Gln Val Val Lys Leu Glu Ala Leu Gln Glu Leu Asn Val 
465                 470                 475                 480 


Ala Phe Asn Ser Leu Thr Asp Leu Pro Gly Cys Gly Ser Phe Ser Ser 
                485                 490                 495     


Leu Ser Val Leu Ile Ile Asp His Asn Ser Val Ser His Pro Ser Ala 
            500                 505                 510         


Asp Phe Phe Gln Ser Cys Gln Lys Met Arg Ser Ile Lys Ala Gly Asp 
        515                 520                 525             


Asn Pro Phe Gln Cys Thr Cys Glu Leu Arg Glu Phe Val Lys Asn Ile 
    530                 535                 540                 


Asp Gln Val Ser Ser Glu Val Leu Glu Gly Trp Pro Asp Ser Tyr Lys 
545                 550                 555                 560 


Cys Asp Tyr Pro Glu Ser Tyr Arg Gly Ser Pro Leu Lys Asp Phe His 
                565                 570                 575     


Met Ser Glu Leu Ser Cys Asn Ile Thr Leu Leu Ile Val Thr Ile Gly 
            580                 585                 590         


Ala Thr Met Leu Val Leu Ala Val Thr Val Thr Ser Leu Cys Ile Tyr 
        595                 600                 605             


Leu Asp Leu Pro Trp Tyr Leu Arg Met Val Cys Gln Trp Thr Gln Thr 
    610                 615                 620                 


Arg Arg Arg Ala Arg Asn Ile Pro Leu Glu Glu Leu Gln Arg Asn Leu 
625                 630                 635                 640 


Gln Phe His Ala Phe Ile Ser Tyr Ser Glu His Asp Ser Ala Trp Val 
                645                 650                 655     


Lys Ser Glu Leu Val Pro Tyr Leu Glu Lys Glu Asp Ile Gln Ile Cys 
            660                 665                 670         


Leu His Glu Arg Asn Phe Val Pro Gly Lys Ser Ile Val Glu Asn Ile 
        675                 680                 685             


Ile Asn Cys Ile Glu Lys Ser Tyr Lys Ser Ile Phe Val Leu Ser Pro 
    690                 695                 700                 


Asn Phe Val Gln Ser Glu Trp Cys His Tyr Glu Leu Tyr Phe Ala His 
705                 710                 715                 720 


His Asn Leu Phe His Glu Gly Ser Asn Asn Leu Ile Leu Ile Leu Leu 
                725                 730                 735     


Glu Pro Ile Pro Gln Asn Ser Ile Pro Asn Lys Tyr His Lys Leu Lys 
            740                 745                 750         


Ala Leu Met Thr Gln Arg Thr Tyr Leu Gln Trp Pro Lys Glu Lys Ser 
        755                 760                 765             


Lys Arg Gly Leu Phe Trp Ala Asn Ile Arg Ala Ala Phe Asn Met Lys 
    770                 775                 780                 


Leu Thr Leu Val Thr Glu Asn Asn Asp Val Lys Ser 
785                 790                 795     


<210>  37
<211>  1063
<212>  PRT
<213>  artificial

<220>
<223>  Salmo salar TLR7

<400>  37

Met Leu Ser Arg Met Thr Arg Ser Glu Cys Ala Ser Phe His Val Cys 
1               5                   10                  15      


Gly Val Ile Leu Leu Gly Leu Trp Cys Ser Ser Val Leu Ala Ala Gly 
            20                  25                  30          


Ser Trp Tyr Pro Lys Thr Leu Pro Cys Asp Val Thr Leu Asp Ser Asn 
        35                  40                  45              


Asp Thr Met Val Asn Val Asp Cys Thr Glu Arg Gly Leu Leu Glu Val 
    50                  55                  60                  


Pro Lys Asp Ile Pro Arg Asn Thr Thr Asn Leu Thr Leu Thr Ile Asn 
65                  70                  75                  80  


His Ile Pro His Ile Asn Ser Thr Ser Phe Gln Gly Leu Glu Asn Leu 
                85                  90                  95      


Thr Glu Ile Asp Met Arg Cys Asn Cys Val Pro Ile Lys Ile Gly Pro 
            100                 105                 110         


Lys Asp Arg Met Cys Thr Glu Ser Val Thr Ile Lys Thr Asn Thr Phe 
        115                 120                 125             


Lys Asp Leu Arg Asn Leu Lys Ala Leu Tyr Leu Asp Gly Asn Gln Leu 
    130                 135                 140                 


Ser Ser Ile Pro Lys Gly Leu Pro Pro Asn Leu Ile Leu Leu Ser Leu 
145                 150                 155                 160 


Glu Val Asn Lys Ile Tyr Thr Ile Leu Lys Arg Asn Leu Ser Asp Ile 
                165                 170                 175     


Thr Asn Val Gln Ile Leu Tyr Leu Gly Gln Asn Cys Tyr Tyr Arg Asn 
            180                 185                 190         


Pro Cys Asn Val Ser Tyr Gln Ile Glu Glu Gly Ala Phe Leu Gln Leu 
        195                 200                 205             


Gly Asn Met Thr Leu Leu Ser Leu Lys Ser Asn Asn Leu Ser Tyr Ile 
    210                 215                 220                 


Pro Pro Arg Leu Pro Thr Ser Leu Arg Glu Leu Tyr Leu Tyr Asn Asn 
225                 230                 235                 240 


Lys Ile Glu Met Val Thr Asp Lys Asp Phe His Asn Leu Thr Gln Leu 
                245                 250                 255     


Glu Ile Leu Asp Leu Cys Gly Asn Cys Pro Arg Cys Tyr Asn Ala Pro 
            260                 265                 270         


Phe Pro Cys Ile Pro Cys Pro Asn Asn Ser Leu Gln Ile Asp Pro Ser 
        275                 280                 285             


Thr Phe Lys Thr Leu Thr Lys Leu Arg Ile Leu Arg Leu His Ser Asn 
    290                 295                 300                 


Ser Leu Thr Tyr Val Leu Arg Glu Trp Phe Gln Asn Cys Lys Glu Leu 
305                 310                 315                 320 


Arg Val Leu Asp Leu Ser Thr Asn Phe Leu Ala Arg Glu Ile Ala Ile 
                325                 330                 335     


Thr Tyr Phe Pro Arg Ala Leu Pro Asn Leu Glu Glu Leu Asp Leu Ser 
            340                 345                 350         


Phe Asn Tyr Glu Leu Gln Arg Tyr Pro Ala Thr Leu His Leu Ser Pro 
        355                 360                 365             


Ser Phe Ser Ser Leu Lys Ser Leu Lys Val Leu Arg Ile Arg Ala Phe 
    370                 375                 380                 


Val Phe Gln Gln Leu Thr Leu Glu Asp Ile Ser Pro Leu Ile His Leu 
385                 390                 395                 400 


Lys Asn Leu Glu Val Ile Asp Leu Gly Thr Asn Phe Ile Lys Ile Thr 
                405                 410                 415     


Asn Leu Ser Ile Leu Met Glu Leu Lys Ser Phe Lys Ile Ile Asn Leu 
            420                 425                 430         


Ser Asp Asn Lys Ile Ser Ser Pro Ser Glu Ser Gly Gln Ser Val Ala 
        435                 440                 445             


Phe Ser Gly Gly Glu Ala Ile His Gly Ser Pro Met Ser Asp Ala Gly 
    450                 455                 460                 


His Asn Arg Asn Gly Glu Val Arg Glu Ile His Tyr Phe Arg Tyr Asp 
465                 470                 475                 480 


Glu Tyr Ala Arg Ser Cys Lys Tyr Lys Asp Lys Glu Asp Gly Thr Leu 
                485                 490                 495     


Asn Ser Phe Val Asn Thr Gln Cys Ser Lys Phe Gly Lys Thr Leu Asp 
            500                 505                 510         


Ile Ser Arg Asn Asn Ile Phe Phe Leu His Ser Arg Phe Leu Asn Leu 
        515                 520                 525             


Ala Asp Leu Arg Cys Leu Asn Leu Ser Gly Asn Ala Met Ser Gln Ser 
    530                 535                 540                 


Leu Asn Gly Ser Glu Phe Thr Phe Leu Thr Lys Leu Gln Tyr Leu Asp 
545                 550                 555                 560 


Phe Ser Phe Asn Arg Leu Asp Leu Leu Tyr Ser Ser Ala Phe Gln Glu 
                565                 570                 575     


Leu Glu Asn Leu Val Ile Leu Asp Ile Ser Asn Asn Asn His Tyr Phe 
            580                 585                 590         


Glu Ser Glu Gly Leu Thr His Met Leu Asn Phe Thr Lys Asn Leu Thr 
        595                 600                 605             


Lys Leu Lys Ile Leu Leu Met Asn Tyr Asn Lys Ile Ser Thr Ser Thr 
    610                 615                 620                 


Asn Thr Glu Leu Glu Ser Arg Ser Leu Glu Lys Leu Glu Phe Lys Gly 
625                 630                 635                 640 


Asn Arg Leu Asp Met Leu Trp Arg Asp Gly Asp Thr Arg Tyr Ile Asp 
                645                 650                 655     


Tyr Phe Lys Lys Leu Leu Asn Leu Arg Val Leu Asp Ile Ser His Asn 
            660                 665                 670         


Asn Leu Asn Phe Ile Pro Gln Gln Val Phe Gln Gly Leu Pro Asp Lys 
        675                 680                 685             


Leu Thr Asn Leu Tyr Ile Asn Asn Asn Arg Leu Lys Ile Phe Ser Trp 
    690                 695                 700                 


Glu Lys Leu Ile Ile Leu Gln Tyr Leu Glu Val Leu Asp Leu Ser Ser 
705                 710                 715                 720 


Asn Ser Ile Ser Thr Val Pro Pro Glu Leu Ser Asn Cys Thr Lys Ser 
                725                 730                 735     


Leu Lys Thr Leu Leu Leu Arg Arg Asn Gln Ile Ser Lys Leu Ser Ala 
            740                 745                 750         


Tyr Phe Leu Lys Asp Ala Phe Ser Leu Lys Tyr Leu Asp Leu Ser Phe 
        755                 760                 765             


Asn His Ile Gln Asn Ile Glu Gln Thr Ser Ile Pro Asp Asp Val Val 
    770                 775                 780                 


Asp Gln Met Asp Thr Leu Val Leu Asn Asn Asn Lys Phe Met Cys Asn 
785                 790                 795                 800 


Cys Asn Ala Leu Met Phe Val Met Trp Leu Asn Arg Thr Met Val Asn 
                805                 810                 815     


Ile Pro Arg Leu Ala Thr Ala Val Val Cys Ala Ala Pro Gly Ala Gln 
            820                 825                 830         


Arg Gly His Pro Val Ile Ser Leu Asp Leu Glu Leu Gln Ala Cys Gln 
        835                 840                 845             


His Asn Tyr Leu Ser Ile Ile Leu Tyr Ile Leu Leu Thr Ser Leu Val 
    850                 855                 860                 


Leu Ser Phe Val Thr Leu Pro Ile Ser Ser His Leu Phe Leu Trp Asp 
865                 870                 875                 880 


Val Trp Tyr Leu Tyr His Phe Leu Leu Ala Lys Phe Lys Gly Tyr Arg 
                885                 890                 895     


Arg Leu Ser Ser Pro Ser Ala Ala Tyr Asp Ala Phe Val Val Tyr Asp 
            900                 905                 910         


Lys Lys Asp Pro Glu Val Ser Glu Trp Val Leu Lys Glu Leu Leu Val 
        915                 920                 925             


Gln Leu Glu Glu His Gly Asp His Pro Leu Gln Leu Cys Leu Glu Glu 
    930                 935                 940                 


Arg Asp Trp Ile Pro Gly Cys Pro Leu Ile Asp Asn Leu Ser Gln Ser 
945                 950                 955                 960 


Ile His Gln Ser Lys Arg Thr Val Phe Ile Leu Thr Asn Lys Tyr Ile 
                965                 970                 975     


Lys Ser Gly Asp Phe Lys Thr Ala Phe Tyr Met Ala His Gln Arg Leu 
            980                 985                 990         


Met Asp Glu Arg Asp Asp Val Ile  Val Leu Ile Phe Leu  Glu Lys Val 
        995                 1000                 1005             


Pro Ser  His Ser Lys Tyr Leu  Arg Leu Arg Lys Arg  Leu Tyr Arg 
    1010                 1015                 1020             


Arg Ser  Val Ile Glu Trp Pro  Thr Asn Pro Gln Ala  Gln Gln Tyr 
    1025                 1030                 1035             


Phe Trp  Phe Ser Leu Arg Ser  Val Leu Val Thr Asp  Ser Gln Lys 
    1040                 1045                 1050             


Gln Tyr  Ser Asn Leu Phe Lys  Glu Thr Arg 
    1055                 1060             


<210>  38
<211>  1054
<212>  PRT
<213>  artificial

<220>
<223>  Xenopus tropicalis TLR7

<400>  38

Met His Gly Lys Thr Phe Lys Val Phe Tyr Phe Gly Met Arg Arg Gln 
1               5                   10                  15      


Leu Leu Phe Phe Leu Ile Ser Ile Leu Ser Phe Ser Gly Leu Leu Ala 
            20                  25                  30          


Thr Asn Trp Phe Pro Lys Ser Leu Pro Cys Asp Val Glu Gln Asn Ala 
        35                  40                  45              


Lys Gly Asn Val Ile Val Val Asp Cys Ser Asp Arg His Leu Thr Ser 
    50                  55                  60                  


Ile Pro Trp Gly Ile Pro Thr Asn Val Thr Asn Leu Thr Leu Thr Ile 
65                  70                  75                  80  


Asn His Ile Pro Arg Ile Ser Val Asp Ser Phe Ala Glu Phe Thr Asn 
                85                  90                  95      


Leu Val Glu Leu Asp Phe Arg Cys Asn Cys Val Pro Ala Lys Val Gly 
            100                 105                 110         


Pro Lys Asp His Val Cys Thr Lys Arg Leu Asp Val Glu Asp Arg Ser 
        115                 120                 125             


Phe Ala Ser Leu Tyr Asn Leu Arg Ser Leu Tyr Leu Asp Gly Asn Gln 
    130                 135                 140                 


Leu Ile Glu Phe Pro Lys Gly Leu Pro Pro Asn Leu Gln Leu Leu Ser 
145                 150                 155                 160 


Leu Glu Ile Asn Asn Ile Ile Ser Ile Ser Arg Asn Asn Leu Ser Glu 
                165                 170                 175     


Leu Ser Asn Ile Gln Met Leu Tyr Leu Gly Gln Asn Cys Tyr His Arg 
            180                 185                 190         


Asn Pro Cys Ser Asp Ser Phe Lys Ile Glu Lys Asp Ala Phe Lys Asp 
        195                 200                 205             


Leu Lys Asn Leu Ser Ile Leu Ser Met Lys Ser Asn Asn Leu Ser Phe 
    210                 215                 220                 


Val Pro Gly Gly Leu Ser Asp Ser Leu Lys Glu Leu Tyr Leu Tyr Asn 
225                 230                 235                 240 


Asn Ala Ile Gln Tyr Ile Glu Glu His Asp Leu Glu Asn Leu Ile Asn 
                245                 250                 255     


Leu Glu Ile Leu Asp Leu Ser Gly Asn Cys Pro Arg Cys Tyr Asn Ser 
            260                 265                 270         


Pro Phe Pro Cys Thr Pro Cys Pro Asn Asn Ala Pro Ile Gln Ile His 
        275                 280                 285             


Pro Lys Ala Phe Ser Ser Leu Lys Asn Leu Gln Val Leu Arg Leu His 
    290                 295                 300                 


Ser Asn Ser Leu Arg Ser Ile Pro Glu Gln Trp Phe Lys Asn Asn Arg 
305                 310                 315                 320 


Asn Leu Gln Val Leu Asp Leu Ser Glu Asn Phe Leu Ala Ser Glu Ile 
                325                 330                 335     


Ser Thr Ala Asn Phe Leu Lys Tyr Ile Pro Ser Leu Lys Ser Leu Asp 
            340                 345                 350         


Leu Ser Phe Asn Phe Glu Leu Gln Val Tyr Pro Ser Asp Leu Lys Leu 
        355                 360                 365             


Ser Ser Ile Phe Ser Ser Leu Ala Ser Leu Glu Thr Leu Arg Ile Arg 
    370                 375                 380                 


Gly Tyr Val Phe Gln Asn Leu Lys Lys Asn Asn Leu Met Pro Leu Val 
385                 390                 395                 400 


His Leu Pro Asn Leu Thr Leu Leu Asp Leu Ser Thr Asn Phe Ile Lys 
                405                 410                 415     


Val Ala Asp Phe Ser Leu Phe Pro Lys Phe Lys Ser Leu Gln Thr Ile 
            420                 425                 430         


Ile Leu Ser Asn Asn Lys Ile Ser Pro Ser Ser Glu Ala Asn Ile Asp 
        435                 440                 445             


Ser Cys Ser Ala Ser Gln Val Ser Ser Gly His Tyr Ile Gly Arg Thr 
    450                 455                 460                 


Phe Gln Glu Val His Tyr Phe Glu Tyr Asp Glu Asn Ala Arg Lys Cys 
465                 470                 475                 480 


Lys Ala Lys Asp Lys Glu Asn Phe Thr Phe Lys Leu Phe Leu Asn Glu 
                485                 490                 495     


Ser Cys Gln Ala Tyr Gly Gln Ser Leu Asp Leu Ser Gln Asn Asn Ile 
            500                 505                 510         


Phe Phe Val Lys Ala Thr Asp Phe Thr Asn Leu Ser Phe Leu Lys Cys 
        515                 520                 525             


Leu Asn Leu Ser Gly Asn Ala Ile Ser Gln Thr Leu Asn Gly Ser Glu 
    530                 535                 540                 


Phe Arg Asn Leu Asn Arg Leu Lys Tyr Leu Asp Phe Ser Asn Asn Arg 
545                 550                 555                 560 


Ile Asp Leu Leu Tyr Ser Thr Ala Phe Gln Glu Leu Thr Glu Leu Glu 
                565                 570                 575     


Val Leu Asp Ile Ser Asn Asn Asp His Tyr Phe Leu Ala Glu Gly Ile 
            580                 585                 590         


Thr His Val Phe Asn Phe Thr Lys Asn Leu Glu Lys Leu Thr Lys Leu 
        595                 600                 605             


Met Met Asn Asn Asn Gln Ile Ser Thr Ser Thr Asn Arg His Leu Val 
    610                 615                 620                 


Ser Gln Ser Leu Arg Ile Leu Glu Phe Lys Gly Asn Tyr Leu Asn Ile 
625                 630                 635                 640 


Leu Trp Lys Asp Gly Asp Thr Arg Tyr Leu Asn Phe Phe Lys Asn Leu 
                645                 650                 655     


Asn Lys Leu Tyr Lys Leu Asp Ile Ser Glu Asn Ser Leu Thr Phe Val 
            660                 665                 670         


Pro Pro Gly Val Phe Glu Gly Met Pro Pro Asp Leu Leu Glu Leu Tyr 
        675                 680                 685             


Leu Ala Arg Asn Lys Leu Lys Thr Phe Ser Trp Asp Lys Leu His Leu 
    690                 695                 700                 


Leu Glu Lys Leu Ser Val Leu Asp Leu Ser Asn Asn Tyr Leu Thr Thr 
705                 710                 715                 720 


Val Pro Arg Glu Leu Ser Asn Cys Thr Ser Ser Ile Lys Lys Leu Ile 
                725                 730                 735     


Leu Ser Asn Asn Lys Ile Lys Lys Leu Thr Pro Phe Phe Leu Arg Gly 
            740                 745                 750         


Ser Val Ser Leu Lys Tyr Leu Asp Leu Ser Asp Asn Leu Ile Gln Asn 
        755                 760                 765             


Ile Gly His Ser Ser Phe Pro Glu Asp Val Leu Asp Asn Leu Thr Glu 
    770                 775                 780                 


Leu Leu Leu Gln Gly Asn Pro Phe Lys Cys Asn Cys Asn Leu Val Trp 
785                 790                 795                 800 


Leu Val Ser Trp Ile Asn Gln Thr Lys Val Tyr Ile Pro Asn Leu Val 
                805                 810                 815     


Thr Gly Val Thr Cys Ser Gly Pro Gly Ala His Arg Gly Gln Ser Leu 
            820                 825                 830         


Val Leu Leu Asp Leu Tyr Thr Cys Glu Gln Tyr His Leu Asn Leu Ile 
        835                 840                 845             


Leu Gln Ala Leu Ser Ala Ser Phe Ile Ile Cys Leu Met Val Val Ser 
    850                 855                 860                 


Val Ser Ser His Leu Phe Tyr Trp Asp Phe Trp Phe Ile Tyr His Leu 
865                 870                 875                 880 


Phe Lys Ala Lys Ile His Gly Tyr Lys Arg Phe Pro Lys Cys Cys Tyr 
                885                 890                 895     


Asp Ala Leu Ile Met Tyr Asp Thr Lys Asp Ser Ala Val Ser Asp Trp 
            900                 905                 910         


Val Phe Asn Asp Leu Val Asn Ile Leu Glu Lys Gln Gly Asn Lys Met 
        915                 920                 925             


Leu Asn Leu Cys Leu Glu Glu Arg Asp Phe Leu Ala Gly Gln Pro Phe 
    930                 935                 940                 


Leu Asp Asn Leu Ser Glu Ser Ile Gln Ile Ser Arg Lys Thr Val Phe 
945                 950                 955                 960 


Val Leu Thr Arg Lys Tyr Val Lys Lys Gly His Phe Lys Thr Ala Phe 
                965                 970                 975     


Tyr Met Ala His Gln Arg Leu Ile Glu Glu Lys Val Asp Val Ile Ile 
            980                 985                 990         


Leu Ile Leu Leu Glu Lys Thr Leu  Gln Arg Ser Arg Tyr  Leu Arg Leu 
        995                 1000                 1005             


Arg Lys  Arg Leu Cys Ala Asn  Ser Val Leu Tyr Trp  Pro Ser Asn 
    1010                 1015                 1020             


Pro Asn  Ser Gln Ser Tyr Phe  Trp His Cys Leu Lys  Ser Ala Ile 
    1025                 1030                 1035             


Ala Thr  Glu Asn Gln Met Ala  Tyr Asp Lys Leu Phe  Lys Asp His 
    1040                 1045                 1050             


Thr 
    


<210>  39
<211>  1059
<212>  PRT
<213>  artificial

<220>
<223>  Gallus gallus TLR7

<400>  39

Met Thr Asn Leu Ser Glu Val Ala Ala His Arg Lys Met Val His His 
1               5                   10                  15      


Ala Arg Thr Ser Asn Ala Leu Leu Phe Val Leu Leu Phe Leu Phe Pro 
            20                  25                  30          


Met Leu Leu Ser Gly Arg Trp Phe Pro Lys Thr Leu Pro Cys Asp Val 
        35                  40                  45              


Glu Ala Phe Glu Ser Thr Val Arg Val Asp Cys Ser Asp Arg Arg Leu 
    50                  55                  60                  


Lys Glu Val Pro Arg Gly Ile Pro Gly Asn Ala Thr Asn Leu Thr Leu 
65                  70                  75                  80  


Thr Ile Asn His Ile Pro Arg Ile Ser Pro Ala Ser Phe Thr Gln Leu 
                85                  90                  95      


Glu Asn Leu Val Glu Ile Asp Phe Arg Cys Asn Cys Val Pro Pro Arg 
            100                 105                 110         


Leu Gly Pro Lys Asp Asn Val Cys Val Thr Pro Pro Ser Ile Glu Asn 
        115                 120                 125             


Gly Ser Phe Ala Ala Leu Thr Arg Leu Lys Ser Leu Tyr Leu Asp Ala 
    130                 135                 140                 


Asn Gln Leu Ser Lys Ile Pro Arg Gly Leu Pro Ala Thr Leu Arg Leu 
145                 150                 155                 160 


Leu Ser Leu Glu Ala Asn Asn Ile Phe Ser Ile Lys Lys Asn Thr Phe 
                165                 170                 175     


Ser Glu Leu Arg Asn Ile Glu Leu Leu Tyr Leu Gly Gln Asn Cys Tyr 
            180                 185                 190         


Tyr Arg Asn Pro Cys Asn Val Ser Phe Glu Ile Glu Glu Thr Ala Phe 
        195                 200                 205             


Leu Asn Leu Lys Asn Leu Thr Val Leu Ser Leu Lys Ser Asn Asn Leu 
    210                 215                 220                 


Thr Phe Ile Pro Pro Asn Leu Ser Ser Thr Leu Lys Glu Leu Tyr Ile 
225                 230                 235                 240 


Tyr Asn Asn Arg Ile Gln Glu Val Gln Glu His Asp Leu Ser Asn Leu 
                245                 250                 255     


Tyr Asn Leu Glu Ile Leu Asp Leu Ser Gly Asn Cys Pro Arg Cys Tyr 
            260                 265                 270         


Asn Ala Pro Tyr Pro Cys Thr Pro Cys Pro Asn Ile Ser Ile Lys Ile 
        275                 280                 285             


His Ser Lys Ala Phe Tyr Ser Leu Lys Lys Leu Arg Ile Leu Arg Leu 
    290                 295                 300                 


His Ser Asn Ser Leu Gln Ser Ile Pro Ser Ser Trp Phe Lys Asn Ile 
305                 310                 315                 320 


Lys Asn Leu Lys Asn Leu Asp Leu Ser Gln Asn Phe Leu Ile Lys Glu 
                325                 330                 335     


Ile Gly Asp Ala Glu Phe Leu Lys Leu Ile Pro Ser Leu Val Glu Leu 
            340                 345                 350         


Asp Leu Ser Phe Asn Phe Glu Leu Gln Met Tyr Ser Pro Phe Leu Asn 
        355                 360                 365             


Leu Ser Lys Thr Phe Ser Cys Leu Ser Asn Leu Glu Thr Leu Arg Ile 
    370                 375                 380                 


Lys Gly Tyr Val Phe Lys Glu Leu Arg Glu Glu Asn Leu Asp Pro Leu 
385                 390                 395                 400 


Leu Asn Leu Arg Asn Leu Thr Val Leu Asp Leu Gly Thr Asn Phe Ile 
                405                 410                 415     


Lys Ile Ala Asp Leu Arg Val Phe Lys Lys Phe Arg Ser Leu Lys Ile 
            420                 425                 430         


Ile Asp Leu Ser Met Asn Lys Ile Ser Pro Ser Ser Gly Glu Gly Asn 
        435                 440                 445             


Phe Tyr Gly Phe Cys Ser Asp His Arg Ile Thr Val Glu Gln Tyr Ser 
    450                 455                 460                 


Arg His Val Leu Gln Glu Met His Tyr Phe Arg Tyr Asp Glu Tyr Gly 
465                 470                 475                 480 


Arg Ser Cys Lys Ser Lys Asp Lys Glu Ala Asp Ser Tyr Gln Pro Leu 
                485                 490                 495     


Val Asn Gly Asp Cys Met Ser Tyr Gly Glu Thr Leu Asp Leu Ser Arg 
            500                 505                 510         


Asn Asn Ile Phe Phe Val Asn Ser Ile Asp Phe Gln Asp Leu Ser Phe 
        515                 520                 525             


Leu Lys Cys Leu Asn Leu Ser Gly Asn Ala Ile Ser Gln Thr Leu Asn 
    530                 535                 540                 


Gly Ser Glu Phe Tyr Tyr Leu Ser Gly Leu Lys Tyr Leu Asp Phe Ser 
545                 550                 555                 560 


Asn Asn Arg Ile Asp Leu Leu Tyr Ser Thr Ala Phe Lys Glu Leu Lys 
                565                 570                 575     


Phe Leu Glu Ile Leu Asp Leu Ser Asn Asn Lys His Tyr Phe Leu Ala 
            580                 585                 590         


Glu Gly Val Ser His Val Leu Ser Phe Met Lys Asn Leu Ala Tyr Leu 
        595                 600                 605             


Lys Lys Leu Met Met Asn Glu Asn Glu Ile Ser Thr Ser Ile Ser Thr 
    610                 615                 620                 


Gly Met Glu Ser Gln Ser Leu Gln Thr Leu Glu Phe Arg Gly Asn Arg 
625                 630                 635                 640 


Leu Asp Ile Phe Trp Ser Asp Gly Lys Lys Glu Tyr Leu Ser Phe Phe 
                645                 650                 655     


Lys Asn Leu Thr Asn Leu Glu Gln Leu Asp Ile Ser Ser Asn Met Leu 
            660                 665                 670         


Asn Phe Leu Pro Pro Asp Val Phe Glu Ala Met Pro Pro Glu Leu Lys 
        675                 680                 685             


Ile Leu Asn Leu Thr Ser Asn Arg Leu His Thr Phe Asn Trp Gly Lys 
    690                 695                 700                 


Leu His Leu Leu Thr Lys Leu Ile Thr Leu Asp Leu Ser Asn Asn Leu 
705                 710                 715                 720 


Leu Thr Thr Val Pro Arg Lys Leu Ser Asn Cys Thr Ser Thr Leu Gln 
                725                 730                 735     


Glu Leu Ile Leu Arg Asn Asn Arg Ile Thr Arg Ile Thr Lys Tyr Phe 
            740                 745                 750         


Leu Arg Gly Ala Ile Gln Leu Thr Tyr Leu Asp Leu Ser Ser Asn Lys 
        755                 760                 765             


Ile Gln Ile Ile Lys Lys Ser Ser Phe Pro Glu Asn Ile Ile Asn Asn 
    770                 775                 780                 


Leu Arg Met Leu Leu Leu His Asn Asn Pro Phe Lys Cys Asn Cys Asp 
785                 790                 795                 800 


Ala Val Trp Phe Val Gly Trp Ile Asn Gln Thr Gln Val Ala Ile Pro 
                805                 810                 815     


Leu Leu Ala Thr Asp Val Thr Cys Ala Gly Pro Gly Ala His Lys Gly 
            820                 825                 830         


Arg Ser Leu Val Phe Leu Asp Leu Asn Thr Cys Glu Leu Asp Thr Ser 
        835                 840                 845             


Tyr Phe Ile Met Tyr Ala Leu Ser Thr Ser Ala Val Leu Cys Leu Met 
    850                 855                 860                 


Met Phe Ala Val Met Ser His Leu Tyr Phe Trp Asp Val Trp Tyr Ser 
865                 870                 875                 880 


Tyr His Tyr Cys Thr Ala Lys Leu Lys Gly Tyr Arg Arg Ile Pro Leu 
                885                 890                 895     


Pro Asp Ala Cys Tyr Asp Ala Phe Ile Ala Tyr Asp Asn Thr Asp Leu 
            900                 905                 910         


Ala Val Asn Glu Trp Val Met Thr Glu Leu Val Glu Lys Leu Glu Asp 
        915                 920                 925             


Gln Lys Ala Arg Gln Phe Asn Leu Cys Leu Glu Glu Arg Asp Trp Leu 
    930                 935                 940                 


Pro Gly Gln Pro Val Phe Asp Asn Leu Ser Gln Ser Ile Gln Leu Ser 
945                 950                 955                 960 


Lys Lys Thr Ile Phe Val Leu Thr Asn Lys Tyr Ile Lys Ser Gly Thr 
                965                 970                 975     


Phe Lys Thr Thr Phe Tyr Met Ala His Gln Arg Leu Leu Asp Glu Lys 
            980                 985                 990         


Ile Asp Val Ile Ile Leu Ile Phe  Leu Glu Lys Val Leu  Gln Lys Ser 
        995                 1000                 1005             


Arg Tyr  Val Gln Leu Arg Lys  Arg Leu Cys Arg Ser  Ser Val Leu 
    1010                 1015                 1020             


Glu Trp  Pro Thr Asn Pro Arg  Ser Gln Pro Tyr Phe  Trp Gln Arg 
    1025                 1030                 1035             


Leu Lys  Asn Ala Ile Ala Met  Asn Asn Thr Leu Ser  Tyr Asn Lys 
    1040                 1045                 1050             


Leu Leu  Gln Glu Thr Val 
    1055                 


<210>  40
<211>  1050
<212>  PRT
<213>  artificial

<220>
<223>  Rattus norvegius TLR7

<400>  40

Met Val Phe Pro Met Trp Thr Leu Lys Arg Gln Ser Phe Ile Phe Leu 
1               5                   10                  15      


Asn Met Ile Leu Val Ser Arg Val Leu Gly Phe Arg Trp Tyr Pro Lys 
            20                  25                  30          


Thr Leu Pro Cys Asp Val Ser Leu Asp Ser Thr Asn Thr His Val Ile 
        35                  40                  45              


Val Asp Cys Thr Asp Lys His Leu Thr Glu Ile Pro Glu Gly Ile Pro 
    50                  55                  60                  


Thr Asn Thr Thr Asn Leu Thr Leu Thr Ile Asn His Ile Pro Ser Ile 
65                  70                  75                  80  


Ser Pro Asp Ser Phe His Arg Leu Lys His Leu Glu Glu Leu Asp Leu 
                85                  90                  95      


Arg Cys Asn Cys Val Pro Ile Leu Leu Gly Ser Lys Ala Asn Val Cys 
            100                 105                 110         


Thr Lys Arg Leu Gln Ile Arg Pro Gly Ser Phe Ser Gly Leu Ser Asp 
        115                 120                 125             


Leu Lys Ser Leu Tyr Leu Asp Gly Asn Gln Leu Leu Glu Ile Pro Gln 
    130                 135                 140                 


Asp Leu Pro Ser Ser Leu Gln Leu Leu Ser Leu Glu Ala Asn Asn Ile 
145                 150                 155                 160 


Phe Ser Ile Thr Lys Glu Asn Leu Ser Glu Leu Val Asn Ile Glu Ser 
                165                 170                 175     


Leu Tyr Leu Gly Gln Asn Cys Tyr Tyr Arg Asn Pro Cys Asn Val Ser 
            180                 185                 190         


Tyr Ser Ile Glu Lys Asp Ala Phe Leu Val Met Lys Asn Leu Lys Val 
        195                 200                 205             


Leu Ser Leu Lys Asp Asn Asn Val Thr Ala Val Pro Thr Ile Leu Pro 
    210                 215                 220                 


Pro Asn Leu Leu Glu Leu Tyr Leu Tyr Asn Asn Ile Ile Lys Arg Ile 
225                 230                 235                 240 


Gln Glu His Asp Phe Asn Lys Leu Ser Gln Leu Gln Val Leu Asp Leu 
                245                 250                 255     


Ser Gly Asn Cys Pro Arg Cys Tyr Asn Val Pro Tyr Pro Cys Thr Pro 
            260                 265                 270         


Cys Glu Asn Asn Ser Pro Leu Gln Ile His Asp Asn Ala Phe Asp Ser 
        275                 280                 285             


Leu Thr Glu Leu Lys Val Leu Arg Leu His Ser Asn Ser Leu Gln His 
    290                 295                 300                 


Val Pro Ala Glu Trp Phe Lys Asn Met Ser Asn Leu Gln Glu Leu Asp 
305                 310                 315                 320 


Leu Ser Gln Asn Tyr Leu Ala Arg Glu Ile Glu Glu Ala Lys Phe Leu 
                325                 330                 335     


Asn Ser Leu Pro Asn Leu Val Gln Leu Asp Leu Ser Phe Asn Tyr Glu 
            340                 345                 350         


Leu Gln Val Tyr His Ala Ser Ile Thr Leu Pro His Ser Leu Ser Ser 
        355                 360                 365             


Leu Thr Lys Leu Lys Asn Leu Tyr Ile Lys Gly Tyr Val Phe Lys Glu 
    370                 375                 380                 


Leu Lys Asp Ser Ser Leu Ser Val Leu His Asn Leu Ser Asn Leu Glu 
385                 390                 395                 400 


Val Leu Asp Leu Gly Thr Asn Phe Ile Lys Ile Ala Asp Leu Asn Ile 
                405                 410                 415     


Phe Gln Gln Phe Glu Asn Leu Lys Phe Ile Asp Leu Ser Val Asn Lys 
            420                 425                 430         


Ile Ser Pro Ser Glu Glu Ser Arg Glu Val Gly Leu Cys Pro Asn Ala 
        435                 440                 445             


Gln Thr Ser Val Asp Trp His Gly Pro Gln Val Leu Glu Ala Leu His 
    450                 455                 460                 


Tyr Phe Arg Tyr Asp Glu Tyr Ala Arg Ser Cys Arg Phe Lys Asn Lys 
465                 470                 475                 480 


Glu Pro Pro Thr Phe Leu Pro Leu Asn Ala Asp Cys His Thr Tyr Gly 
                485                 490                 495     


Lys Thr Leu Asp Leu Ser Arg Asn Asn Ile Phe Phe Ile Lys Pro Ser 
            500                 505                 510         


Asp Phe Lys His Leu Ser Phe Leu Lys Cys Leu Asn Leu Ser Gly Asn 
        515                 520                 525             


Ala Ile Gly Gln Thr Leu Asn Gly Ser Glu Leu Gln Pro Leu Arg Glu 
    530                 535                 540                 


Leu Arg Tyr Leu Asp Phe Ser Asn Asn Arg Leu Asp Leu Leu Tyr Ser 
545                 550                 555                 560 


Thr Ala Phe Glu Glu Leu Gln Asn Leu Glu Ile Leu Asp Leu Ser Ser 
                565                 570                 575     


Asn Ser His Tyr Phe Gln Ala Glu Gly Ile Thr His Met Leu Asn Phe 
            580                 585                 590         


Thr Lys Lys Leu Arg His Leu Glu Lys Leu Met Met Asn Asp Asn Asp 
        595                 600                 605             


Ile Ser Thr Ser Ala Ser Arg Thr Met Glu Ser Glu Ser Leu Arg Val 
    610                 615                 620                 


Leu Glu Phe Arg Gly Asn His Leu Asp Val Leu Trp Arg Asp Gly Asp 
625                 630                 635                 640 


Asn Arg Tyr Leu Asp Phe Phe Lys Asn Leu Leu Asn Leu Glu Glu Leu 
                645                 650                 655     


Asp Ile Ser Arg Asn Ser Leu Asn Ser Val Pro Pro Gly Val Phe Glu 
            660                 665                 670         


Gly Met Pro Pro Asn Leu Thr Thr Leu Ser Leu Ala Lys Asn Gly Leu 
        675                 680                 685             


Arg Ser Phe Ser Trp Gly Arg Leu Gln Leu Leu Lys His Leu Lys Asn 
    690                 695                 700                 


Leu Asp Leu Ser His Asn Gln Leu Thr Thr Val Pro Ala Arg Leu Ala 
705                 710                 715                 720 


Asn Cys Ser Lys Ser Leu Thr Lys Leu Ile Leu Asn His Asn Gln Ile 
                725                 730                 735     


Arg Gln Leu Thr Lys Tyr Phe Leu Glu Asp Ala Leu Gln Leu Arg Tyr 
            740                 745                 750         


Leu Asp Ile Ser Ser Asn Lys Ile Gln Val Ile Gln Lys Thr Ser Phe 
        755                 760                 765             


Pro Glu Asn Val Leu Asn Asn Leu Asn Met Leu Leu Leu His His Asn 
    770                 775                 780                 


Arg Phe Leu Cys Asn Cys Asp Ala Val Trp Phe Val Trp Trp Val Asn 
785                 790                 795                 800 


His Thr Asp Val Thr Ile Pro Tyr Leu Ala Thr Asp Val Thr Cys Ala 
                805                 810                 815     


Gly Pro Gly Ala His Lys Gly Gln Ser Val Ile Ser Leu Asp Leu Tyr 
            820                 825                 830         


Thr Cys Glu Leu Asp Leu Thr Asn Leu Ile Leu Phe Ser Val Ser Ile 
        835                 840                 845             


Ser Ser Val Leu Phe Leu Met Ile Val Met Thr Thr Ser His Leu Phe 
    850                 855                 860                 


Phe Trp Asp Met Trp Tyr Ile Tyr Tyr Phe Trp Lys Ala Lys Ile Lys 
865                 870                 875                 880 


Gly Tyr Gln His Leu Gln Ser Met Glu Ser Cys Tyr Asp Ala Phe Ile 
                885                 890                 895     


Val Tyr Asp Thr Lys Asn Ser Ala Val Thr Glu Trp Val Leu Gln Glu 
            900                 905                 910         


Leu Val Val Lys Leu Glu Asp Pro Arg Glu Lys His Phe Asn Leu Cys 
        915                 920                 925             


Leu Glu Glu Arg Asp Trp Leu Pro Gly Gln Pro Val Leu Glu Asn Leu 
    930                 935                 940                 


Ser Gln Ser Ile Gln Leu Ser Arg Lys Thr Val Phe Val Met Thr Gln 
945                 950                 955                 960 


Lys Tyr Ala Lys Thr Glu Ser Phe Lys Met Ala Phe Tyr Leu Ser His 
                965                 970                 975     


Gln Arg Leu Met Asp Glu Lys Val Asp Val Ile Ile Leu Ile Phe Leu 
            980                 985                 990         


Glu Lys Pro Leu Gln Lys Ser Lys  Phe Leu Gln Leu Arg  Lys Arg Leu 
        995                 1000                 1005             


Cys Ser  Ser Ser Val Leu Glu  Trp Pro Thr Asn Pro  Gln Ala His 
    1010                 1015                 1020             


Pro Tyr  Phe Trp Gln Cys Leu  Lys Asn Ala Leu Thr  Thr Asp Asn 
    1025                 1030                 1035             


His Val  Ala Tyr Ser Gln Met  Phe Lys Glu Thr Val  
    1040                 1045                 1050 


<210>  41
<211>  1049
<212>  PRT
<213>  artificial

<220>
<223>  Homo sapiens TLR7

<400>  41

Met Val Phe Pro Met Trp Thr Leu Lys Arg Leu Ile Leu Ile Leu Phe 
1               5                   10                  15      


Asn Ile Ile Leu Ile Ser Lys Leu Leu Gly Ala Arg Trp Phe Pro Lys 
            20                  25                  30          


Thr Leu Pro Cys Asp Val Thr Leu Asp Val Pro Lys Asn His Val Ile 
        35                  40                  45              


Val Asp Cys Thr Asp Lys His Leu Thr Glu Ile Pro Gly Gly Ile Pro 
    50                  55                  60                  


Thr Asn Thr Thr Asn Leu Thr Leu Thr Ile Asn His Ile Pro Asp Ile 
65                  70                  75                  80  


Ser Pro Ala Ser Phe His Arg Leu Asp His Leu Val Glu Ile Asp Phe 
                85                  90                  95      


Arg Cys Asn Cys Val Pro Ile Pro Leu Gly Ser Lys Asn Asn Met Cys 
            100                 105                 110         


Ile Lys Arg Leu Gln Ile Lys Pro Arg Ser Phe Ser Gly Leu Thr Tyr 
        115                 120                 125             


Leu Lys Ser Leu Tyr Leu Asp Gly Asn Gln Leu Leu Glu Ile Pro Gln 
    130                 135                 140                 


Gly Leu Pro Pro Ser Leu Gln Leu Leu Ser Leu Glu Ala Asn Asn Ile 
145                 150                 155                 160 


Phe Ser Ile Arg Lys Glu Asn Leu Thr Glu Leu Ala Asn Ile Glu Ile 
                165                 170                 175     


Leu Tyr Leu Gly Gln Asn Cys Tyr Tyr Arg Asn Pro Cys Tyr Val Ser 
            180                 185                 190         


Tyr Ser Ile Glu Lys Asp Ala Phe Leu Asn Leu Thr Lys Leu Lys Val 
        195                 200                 205             


Leu Ser Leu Lys Asp Asn Asn Val Thr Ala Val Pro Thr Val Leu Pro 
    210                 215                 220                 


Ser Thr Leu Thr Glu Leu Tyr Leu Tyr Asn Asn Met Ile Ala Lys Ile 
225                 230                 235                 240 


Gln Glu Asp Asp Phe Asn Asn Leu Asn Gln Leu Gln Ile Leu Asp Leu 
                245                 250                 255     


Ser Gly Asn Cys Pro Arg Cys Tyr Asn Ala Pro Phe Pro Cys Ala Pro 
            260                 265                 270         


Cys Lys Asn Asn Ser Pro Leu Gln Ile Pro Val Asn Ala Phe Asp Ala 
        275                 280                 285             


Leu Thr Glu Leu Lys Val Leu Arg Leu His Ser Asn Ser Leu Gln His 
    290                 295                 300                 


Val Pro Pro Arg Trp Phe Lys Asn Ile Asn Lys Leu Gln Glu Leu Asp 
305                 310                 315                 320 


Leu Ser Gln Asn Phe Leu Ala Lys Glu Ile Gly Asp Ala Lys Phe Leu 
                325                 330                 335     


His Phe Leu Pro Ser Leu Ile Gln Leu Asp Leu Ser Phe Asn Phe Glu 
            340                 345                 350         


Leu Gln Val Tyr Arg Ala Ser Met Asn Leu Ser Gln Ala Phe Ser Ser 
        355                 360                 365             


Leu Lys Ser Leu Lys Ile Leu Arg Ile Arg Gly Tyr Val Phe Lys Glu 
    370                 375                 380                 


Leu Lys Ser Phe Asn Leu Ser Pro Leu His Asn Leu Gln Asn Leu Glu 
385                 390                 395                 400 


Val Leu Asp Leu Gly Thr Asn Phe Ile Lys Ile Ala Asn Leu Ser Met 
                405                 410                 415     


Phe Lys Gln Phe Lys Arg Leu Lys Val Ile Asp Leu Ser Val Asn Lys 
            420                 425                 430         


Ile Ser Pro Ser Gly Asp Ser Ser Glu Val Gly Phe Cys Ser Asn Ala 
        435                 440                 445             


Arg Thr Ser Val Glu Ser Tyr Glu Pro Gln Val Leu Glu Gln Leu His 
    450                 455                 460                 


Tyr Phe Arg Tyr Asp Lys Tyr Ala Arg Ser Cys Arg Phe Lys Asn Lys 
465                 470                 475                 480 


Glu Ala Ser Phe Met Ser Val Asn Glu Ser Cys Tyr Lys Tyr Gly Gln 
                485                 490                 495     


Thr Leu Asp Leu Ser Lys Asn Ser Ile Phe Phe Val Lys Ser Ser Asp 
            500                 505                 510         


Phe Gln His Leu Ser Phe Leu Lys Cys Leu Asn Leu Ser Gly Asn Leu 
        515                 520                 525             


Ile Ser Gln Thr Leu Asn Gly Ser Glu Phe Gln Pro Leu Ala Glu Leu 
    530                 535                 540                 


Arg Tyr Leu Asp Phe Ser Asn Asn Arg Leu Asp Leu Leu His Ser Thr 
545                 550                 555                 560 


Ala Phe Glu Glu Leu His Lys Leu Glu Val Leu Asp Ile Ser Ser Asn 
                565                 570                 575     


Ser His Tyr Phe Gln Ser Glu Gly Ile Thr His Met Leu Asn Phe Thr 
            580                 585                 590         


Lys Asn Leu Lys Val Leu Gln Lys Leu Met Met Asn Asp Asn Asp Ile 
        595                 600                 605             


Ser Ser Ser Thr Ser Arg Thr Met Glu Ser Glu Ser Leu Arg Thr Leu 
    610                 615                 620                 


Glu Phe Arg Gly Asn His Leu Asp Val Leu Trp Arg Glu Gly Asp Asn 
625                 630                 635                 640 


Arg Tyr Leu Gln Leu Phe Lys Asn Leu Leu Lys Leu Glu Glu Leu Asp 
                645                 650                 655     


Ile Ser Lys Asn Ser Leu Ser Phe Leu Pro Ser Gly Val Phe Asp Gly 
            660                 665                 670         


Met Pro Pro Asn Leu Lys Asn Leu Ser Leu Ala Lys Asn Gly Leu Lys 
        675                 680                 685             


Ser Phe Ser Trp Lys Lys Leu Gln Cys Leu Lys Asn Leu Glu Thr Leu 
    690                 695                 700                 


Asp Leu Ser His Asn Gln Leu Thr Thr Val Pro Glu Arg Leu Ser Asn 
705                 710                 715                 720 


Cys Ser Arg Ser Leu Lys Asn Leu Ile Leu Lys Asn Asn Gln Ile Arg 
                725                 730                 735     


Ser Leu Thr Lys Tyr Phe Leu Gln Asp Ala Phe Gln Leu Arg Tyr Leu 
            740                 745                 750         


Asp Leu Ser Ser Asn Lys Ile Gln Met Ile Gln Lys Thr Ser Phe Pro 
        755                 760                 765             


Glu Asn Val Leu Asn Asn Leu Lys Met Leu Leu Leu His His Asn Arg 
    770                 775                 780                 


Phe Leu Cys Thr Cys Asp Ala Val Trp Phe Val Trp Trp Val Asn His 
785                 790                 795                 800 


Thr Glu Val Thr Ile Pro Tyr Leu Ala Thr Asp Val Thr Cys Val Gly 
                805                 810                 815     


Pro Gly Ala His Lys Gly Gln Ser Val Ile Ser Leu Asp Leu Tyr Thr 
            820                 825                 830         


Cys Glu Leu Asp Leu Thr Asn Leu Ile Leu Phe Ser Leu Ser Ile Ser 
        835                 840                 845             


Val Ser Leu Phe Leu Met Val Met Met Thr Ala Ser His Leu Tyr Phe 
    850                 855                 860                 


Trp Asp Val Trp Tyr Ile Tyr His Phe Cys Lys Ala Lys Ile Lys Gly 
865                 870                 875                 880 


Tyr Gln Arg Leu Ile Ser Pro Asp Cys Cys Tyr Asp Ala Phe Ile Val 
                885                 890                 895     


Tyr Asp Thr Lys Asp Pro Ala Val Thr Glu Trp Val Leu Ala Glu Leu 
            900                 905                 910         


Val Ala Lys Leu Glu Asp Pro Arg Glu Lys His Phe Asn Leu Cys Leu 
        915                 920                 925             


Glu Glu Arg Asp Trp Leu Pro Gly Gln Pro Val Leu Glu Asn Leu Ser 
    930                 935                 940                 


Gln Ser Ile Gln Leu Ser Lys Lys Thr Val Phe Val Met Thr Asp Lys 
945                 950                 955                 960 


Tyr Ala Lys Thr Glu Asn Phe Lys Ile Ala Phe Tyr Leu Ser His Gln 
                965                 970                 975     


Arg Leu Met Asp Glu Lys Val Asp Val Ile Ile Leu Ile Phe Leu Glu 
            980                 985                 990         


Lys Pro Phe Gln Lys Ser Lys Phe  Leu Gln Leu Arg Lys  Arg Leu Cys 
        995                 1000                 1005             


Gly Ser  Ser Val Leu Glu Trp  Pro Thr Asn Pro Gln  Ala His Pro 
    1010                 1015                 1020             


Tyr Phe  Trp Gln Cys Leu Lys  Asn Ala Leu Ala Thr  Asp Asn His 
    1025                 1030                 1035             


Val Ala  Tyr Ser Gln Val Phe  Lys Glu Thr Val 
    1040                 1045                 


<210>  42
<211>  1050
<212>  PRT
<213>  artificial

<220>
<223>  Sus scrofa TLR7

<400>  42

Met Val Phe Pro Val Trp Thr Leu Lys Arg Gln Phe Leu Ile Leu Phe 
1               5                   10                  15      


Asn Ile Val Leu Ile Ser Glu Leu Leu Gly Ala Arg Trp Phe Pro Lys 
            20                  25                  30          


Thr Leu Pro Cys Asp Val Ser Leu Asp Ala Pro Asn Ala His Val Ile 
        35                  40                  45              


Val Asp Cys Thr Asp Lys His Leu Thr Ala Ile Pro Gly Gly Ile Pro 
    50                  55                  60                  


Thr Asn Ala Thr Asn Leu Thr Leu Thr Ile Asn His Ile Ala Ser Ile 
65                  70                  75                  80  


Thr Pro Ala Ser Phe Gln Gln Leu Asp His Leu Val Glu Ile Asp Phe 
                85                  90                  95      


Arg Cys Asn Cys Ile Pro Val Arg Leu Gly Pro Lys Asp Asn Leu Cys 
            100                 105                 110         


Thr Arg Arg Leu Gln Ile Lys Pro Ser Ser Phe Ser Lys Leu Thr Tyr 
        115                 120                 125             


Leu Lys Ala Leu Tyr Leu Asp Gly Asn Gln Leu Leu Glu Ile Pro Arg 
    130                 135                 140                 


Asp Leu Pro Pro Ser Leu Gln Leu Leu Ser Leu Glu Ala Asn Asn Ile 
145                 150                 155                 160 


Phe Trp Ile Met Lys Glu Asn Leu Thr Glu Leu Ala Asn Leu Glu Met 
                165                 170                 175     


Leu Tyr Leu Gly Gln Asn Cys Tyr Tyr Arg Asn Pro Cys Asn Val Ser 
            180                 185                 190         


Phe Ser Ile Glu Lys Asp Ala Phe Leu Ser Leu Arg Asn Leu Lys Leu 
        195                 200                 205             


Leu Ser Leu Lys Asp Asn Asn Ile Ser Ala Val Pro Thr Val Leu Pro 
    210                 215                 220                 


Ser Thr Leu Thr Glu Leu Phe Leu Tyr Asn Asn Ile Ile Ala Lys Ile 
225                 230                 235                 240 


Gln Glu Asp Asp Phe Asn Asn Leu Ser Gln Leu Gln Val Leu Asp Leu 
                245                 250                 255     


Ser Gly Asn Cys Pro Arg Cys Tyr Asn Val Pro Phe Pro Cys Thr Pro 
            260                 265                 270         


Cys Glu Asn Asn Ala Pro Leu Gln Ile His Leu His Ala Phe Asp Ala 
        275                 280                 285             


Leu Thr Glu Leu Gln Val Leu Arg Leu His Ser Asn Ser Leu Gln Tyr 
    290                 295                 300                 


Val Pro Gln Arg Trp Phe Gln Asn Leu Asn Lys Leu Lys Glu Leu Asp 
305                 310                 315                 320 


Leu Ser Gln Asn Phe Leu Ala Lys Glu Ile Gly Asp Ala Lys Phe Leu 
                325                 330                 335     


His Leu Leu Pro Asn Leu Val Lys Leu Asp Leu Ser Phe Asn Tyr Glu 
            340                 345                 350         


Leu Gln Val Tyr His Thr Phe Met Asn Leu Ser Asp Ser Phe Ser Ser 
        355                 360                 365             


Leu Lys Asn Leu Lys Val Leu Arg Ile Lys Gly Tyr Val Phe Lys Glu 
    370                 375                 380                 


Leu Lys Ser Leu Asn Leu Ser Pro Leu Arg Asn Leu Pro Asn Leu Glu 
385                 390                 395                 400 


Val Leu Asp Leu Gly Thr Asn Phe Ile Lys Ile Ala Asn Leu Ser Ile 
                405                 410                 415     


Phe Lys Gln Phe Lys Thr Leu Lys Phe Ile Asp Leu Ser Val Asn Lys 
            420                 425                 430         


Ile Ser Pro Ser Gly Asp Ser Ser Glu Ser Gly Phe Cys Ser Gly Met 
        435                 440                 445             


Arg Thr Ser Ala Glu Ser His Gly Pro Gln Val Leu Glu Ser Leu His 
    450                 455                 460                 


Tyr Phe Arg Tyr Asp Glu Tyr Ala Arg Ser Cys Arg Phe Lys Asn Lys 
465                 470                 475                 480 


Glu Pro Ser Ser Ser Leu Pro Leu Asn Glu Asp Cys Ser Met Tyr Gly 
                485                 490                 495     


Gln Thr Leu Asp Leu Ser Arg Asn Asn Ile Phe Phe Ile Arg Ser Ser 
            500                 505                 510         


Glu Phe Gln His Leu Thr Phe Leu Lys Cys Leu Asn Leu Ser Gly Asn 
        515                 520                 525             


Ser Ile Ser Gln Ala Leu Asn Gly Ser Glu Phe Gln Pro Leu Val Glu 
    530                 535                 540                 


Leu Lys Tyr Leu Asp Phe Ser Asn Asn Arg Leu Asp Leu Leu His Ser 
545                 550                 555                 560 


Thr Ala Phe Glu Glu Leu Arg Asn Leu Glu Val Leu Asp Ile Ser Ser 
                565                 570                 575     


Asn Ser His Tyr Phe Gln Ser Glu Gly Ile Thr His Met Leu Asp Phe 
            580                 585                 590         


Thr Lys Asn Leu Lys Val Leu Lys Lys Leu Met Met Asn Asn Asn Asp 
        595                 600                 605             


Ile Ala Thr Ser Thr Ser Thr Thr Met Glu Ser Glu Ser Leu Arg Ile 
    610                 615                 620                 


Leu Glu Phe Arg Gly Asn His Leu Asp Ile Leu Trp Arg Asp Gly Asp 
625                 630                 635                 640 


Asn Arg Tyr Leu Lys Phe Phe Lys Asn Leu His Lys Leu Glu Glu Leu 
                645                 650                 655     


Asp Ile Ser Glu Asn Ser Leu Ser Phe Leu Pro Ser Gly Val Phe Asp 
            660                 665                 670         


Gly Met Pro Pro Asn Leu Lys Thr Leu Ser Leu Ala Lys Asn Gly Leu 
        675                 680                 685             


Lys Ser Phe Asn Trp Gly Lys Leu Gln Tyr Leu Gln Asn Leu Glu Thr 
    690                 695                 700                 


Leu Asp Leu Ser Tyr Asn Gln Leu Lys Thr Val Pro Glu Arg Leu Ser 
705                 710                 715                 720 


Asn Cys Ser Arg Ser Leu Lys Lys Leu Ile Leu Lys Asn Asn Glu Ile 
                725                 730                 735     


Arg Asn Leu Thr Lys Tyr Phe Leu Gln Asp Ala Phe Gln Leu Arg His 
            740                 745                 750         


Leu Asp Leu Ser Ser Asn Lys Ile Gln Val Ile Gln Lys Thr Ser Phe 
        755                 760                 765             


Pro Glu Asn Val Leu Asn Asn Leu Gln Ile Leu Phe Leu His His Asn 
    770                 775                 780                 


Arg Phe Leu Cys Asn Cys Asp Ala Val Trp Leu Val Trp Trp Val Asn 
785                 790                 795                 800 


His Thr Glu Val Thr Ile Pro Phe Leu Ala Thr Asp Val Thr Cys Met 
                805                 810                 815     


Gly Pro Gly Ala His Lys Gly Gln Ser Val Val Ser Leu Asp Leu Tyr 
            820                 825                 830         


Thr Cys Glu Leu Asp Leu Thr Asn Phe Val Leu Phe Ser Leu Ser Leu 
        835                 840                 845             


Ser Ala Val Leu Phe Leu Ile Val Ile Thr Ile Ala Asn His Leu Tyr 
    850                 855                 860                 


Phe Trp Asp Val Trp Tyr Ser Tyr His Phe Cys Lys Ala Lys Ile Lys 
865                 870                 875                 880 


Gly Tyr Gln Arg Leu Ile Ser Pro Asn Ser Cys Tyr Asp Ala Phe Ile 
                885                 890                 895     


Val Tyr Asp Thr Lys Asp Pro Ala Val Thr Glu Trp Val Leu Asp Glu 
            900                 905                 910         


Leu Val Ala Lys Leu Glu Asp Pro Arg Glu Lys His Phe Asn Leu Cys 
        915                 920                 925             


Leu Glu Glu Arg Asp Trp Leu Pro Gly Gln Pro Val Leu Glu Asn Leu 
    930                 935                 940                 


Ser Gln Ser Ile Gln Leu Ser Lys Lys Thr Val Phe Val Met Thr Asp 
945                 950                 955                 960 


Lys Tyr Ala Lys Thr Glu Lys Phe Lys Ile Ala Phe Tyr Leu Ser His 
                965                 970                 975     


Gln Arg Leu Met Asp Glu Lys Val Asp Val Ile Ile Leu Ile Phe Leu 
            980                 985                 990         


Glu Lys Pro Leu Gln Lys Ser Lys  Phe Phe Gln Leu Arg  Lys Arg Leu 
        995                 1000                 1005             


Cys Gly  Ser Ser Val Leu Glu  Trp Pro Thr Asn Pro  Gln Ala His 
    1010                 1015                 1020             


Pro Tyr  Phe Trp Gln Cys Leu  Lys Asn Ala Leu Ala  Thr Asp Asn 
    1025                 1030                 1035             


His Val  Thr Tyr Ser Gln Val  Phe Lys Glu Thr Ala  
    1040                 1045                 1050 


<210>  43
<211>  1058
<212>  PRT
<213>  artificial

<220>
<223>  Bos Taurus TLR7

<400>  43

Met Gly Asp Leu Phe Leu Tyr Phe Gln Val Phe Pro Met Trp Thr Leu 
1               5                   10                  15      


Lys Arg Gln Phe Pro Ile Leu Phe Asn Met Ile Leu Ile Ser Gly Leu 
            20                  25                  30          


Leu Gly Ala Arg Trp Phe Pro Lys Thr Leu Pro Cys Asp Val Thr Leu 
        35                  40                  45              


Asp Ala Pro Asn Thr His Val Ile Val Asp Cys Thr Asp Lys His Leu 
    50                  55                  60                  


Thr Glu Ile Pro Gly Gly Ile Pro Ala Asn Ala Thr Asn Leu Thr Leu 
65                  70                  75                  80  


Thr Ile Asn His Ile Ala Gly Ile Ser Pro Ala Ser Phe His Arg Leu 
                85                  90                  95      


Asp His Leu Val Glu Ile Asp Phe Arg Cys Asn Cys Val Pro Val Arg 
            100                 105                 110         


Leu Gly Pro Lys Asp Asn Val Cys Thr Lys Arg Leu Gln Ile Lys Pro 
        115                 120                 125             


Asn Ser Phe Ser Lys Leu Thr Tyr Leu Lys Ser Leu Tyr Leu Asp Gly 
    130                 135                 140                 


Asn Gln Leu Leu Glu Ile Pro Gln Asp Leu Pro Pro Ser Leu Gln Leu 
145                 150                 155                 160 


Leu Ser Leu Glu Ala Asn Asn Ile Phe Leu Ile Met Lys Glu Asn Leu 
                165                 170                 175     


Thr Glu Leu Ala Asn Leu Glu Ile Leu Tyr Leu Gly Gln Asn Cys Tyr 
            180                 185                 190         


Tyr Arg Asn Pro Cys Asn Val Ser Phe Thr Ile Glu Lys Asp Ala Phe 
        195                 200                 205             


Leu Asn Met Arg Asn Leu Lys Leu Leu Ser Leu Lys Asp Asn Asn Ile 
    210                 215                 220                 


Ser Ala Val Pro Thr Val Leu Pro Ser Ser Leu Thr Glu Leu Tyr Leu 
225                 230                 235                 240 


Tyr Asn Asn Ile Ile Thr Lys Ile Gln Glu Asp Asp Phe Asn Asn Leu 
                245                 250                 255     


Ser Gln Leu Gln Val Leu Asp Leu Ser Gly Asn Cys Pro Arg Cys Tyr 
            260                 265                 270         


Asn Val Pro Phe Pro Cys Thr Pro Cys Glu Asn Asn Ser Pro Leu Gln 
        275                 280                 285             


Ile Asp Pro Asn Ala Phe Asp Ala Leu Thr Glu Leu Gln Val Leu Arg 
    290                 295                 300                 


Leu His Ser Asn Ser Leu Gln His Val Pro Gln Arg Trp Phe Lys Asn 
305                 310                 315                 320 


Ile Asn Lys Leu Lys Glu Leu Asp Leu Ser Gln Asn Phe Leu Ala Lys 
                325                 330                 335     


Glu Ile Gly Asp Ala Lys Phe Leu His Leu Leu His Asn Leu Val Asn 
            340                 345                 350         


Leu Asp Leu Ser Phe Asn Tyr Asp Leu Gln Val Tyr His Ala Val Ile 
        355                 360                 365             


Asn Leu Ser Asp Ala Phe Ser Ser Leu Lys Lys Leu Lys Val Leu Arg 
    370                 375                 380                 


Ile Lys Gly Tyr Val Phe Lys Glu Leu Asn Ser Leu Asn Leu Phe Pro 
385                 390                 395                 400 


Leu His Asn Leu Pro Asn Leu Glu Val Leu Asp Leu Gly Thr Asn Phe 
                405                 410                 415     


Ile Lys Ile Ala Asn Leu Ser Ile Phe Asn Gln Phe Lys Thr Leu Lys 
            420                 425                 430         


Phe Ile Asp Leu Ser Val Asn Lys Ile Ser Pro Ser Gly Asp Ser Pro 
        435                 440                 445             


Glu Gly Gly Phe Cys Ser Asn Arg Arg Thr Ser Val Glu Gly His Gly 
    450                 455                 460                 


Pro Gln Val Leu Glu Thr Leu His Tyr Phe Arg Tyr Asp Glu Tyr Ala 
465                 470                 475                 480 


Arg Ser Cys Arg Ser Lys Ser Lys Glu Pro Pro Ser Phe Leu Pro Leu 
                485                 490                 495     


Asn Glu Asp Cys Tyr Met Tyr Gly Gln Thr Leu Asp Leu Ser Arg Asn 
            500                 505                 510         


Asn Ile Phe Phe Ile Lys Pro Ser Asp Phe Gln His Leu Ser Phe Leu 
        515                 520                 525             


Lys Cys Leu Asn Leu Ser Gly Asn Ser Ile Ser Gln Thr Leu Asn Gly 
    530                 535                 540                 


Ser Glu Phe Gln Pro Leu Val Glu Leu Lys Tyr Leu Asp Phe Ser Asn 
545                 550                 555                 560 


Asn Arg Leu Asp Leu Leu Tyr Ser Thr Ala Phe Glu Glu Leu His Asn 
                565                 570                 575     


Leu Glu Val Leu Asp Ile Ser Ser Asn Ser His Tyr Phe Gln Ser Glu 
            580                 585                 590         


Gly Ile Thr His Met Leu Asn Phe Thr Lys Asn Leu Lys Val Leu Arg 
        595                 600                 605             


Lys Leu Met Met Asn Tyr Asn Asp Ile Ala Thr Ser Thr Ser Arg Thr 
    610                 615                 620                 


Met Glu Ser Glu Ser Leu Gln Ile Leu Glu Phe Arg Gly Asn His Leu 
625                 630                 635                 640 


Asp Ile Leu Trp Arg Asp Gly Asp Asn Arg Tyr Leu Lys Phe Phe Lys 
                645                 650                 655     


Asn Leu Leu Asn Leu Glu Glu Leu Asp Ile Ser Glu Asn Ser Leu Ser 
            660                 665                 670         


Phe Leu Pro Leu Gly Val Phe Asp Ser Met Pro Pro Asn Leu Lys Thr 
        675                 680                 685             


Leu Ser Leu Ala Lys Asn Gly Leu Lys Ser Phe Ser Trp Glu Arg Leu 
    690                 695                 700                 


Gln Ser Leu Lys Asn Leu Glu Thr Leu Asp Leu Ser Phe Asn Gln Leu 
705                 710                 715                 720 


Lys Thr Val Pro Glu Arg Leu Ser Asn Cys Ser Arg Ser Leu Lys Lys 
                725                 730                 735     


Leu Ile Leu Lys Asn Asn Gln Ile Arg Cys Leu Thr Lys Tyr Phe Leu 
            740                 745                 750         


Gln Gly Ala Phe Gln Leu Arg His Leu Asp Leu Ser Ser Asn Lys Ile 
        755                 760                 765             


Gln Val Ile Gln Lys Thr Ser Phe Pro Glu Asn Val Leu Asn Asn Leu 
    770                 775                 780                 


Asn Ile Leu Phe Leu His His Asn Arg Phe Leu Cys Asn Cys Asp Ala 
785                 790                 795                 800 


Val Trp Phe Val Trp Trp Val Asn His Thr Glu Val Thr Ile Pro Tyr 
                805                 810                 815     


Leu Ala Thr Asp Val Thr Cys Met Gly Pro Gly Ala His Lys Gly Gln 
            820                 825                 830         


Ser Val Val Ser Leu Asp Leu Tyr Thr Cys Glu Leu Asp Leu Thr Asn 
        835                 840                 845             


Phe Ile Leu Phe Ser Leu Ser Ile Ser Ala Val Leu Ser Leu Met Met 
    850                 855                 860                 


Ile Thr Ile Ala Asn His Leu Tyr Phe Trp Asp Val Trp Tyr Ser Tyr 
865                 870                 875                 880 


His Phe Cys Lys Ala Lys Ile Lys Gly Tyr Arg Arg Leu Ile Ser Pro 
                885                 890                 895     


Asn Ser Cys Tyr Asp Ala Phe Ile Val Tyr Asp Thr Lys Asp Pro Ala 
            900                 905                 910         


Val Thr Glu Trp Val Leu Asp Glu Leu Val Ala Lys Leu Glu Asp Pro 
        915                 920                 925             


Arg Glu Lys Cys Phe Asn Leu Cys Leu Glu Glu Arg Asp Trp Leu Pro 
    930                 935                 940                 


Gly Gln Pro Val Leu Glu Asn Leu Ser Gln Ser Ile Gln Leu Ser Lys 
945                 950                 955                 960 


Lys Thr Val Phe Val Met Thr Asp Lys Tyr Ala Lys Thr Glu Asn Phe 
                965                 970                 975     


Lys Ile Ala Phe Tyr Leu Ser His Gln Arg Leu Met Asp Glu Lys Val 
            980                 985                 990         


Asp Val Ile Ile Leu Ile Phe Leu  Glu Lys Pro Leu Gln  Lys Ser Lys 
        995                 1000                 1005             


Phe Leu  Gln Leu Arg Lys Arg  Leu Cys Gly Ser Ser  Val Leu Glu 
    1010                 1015                 1020             


Trp Pro  Thr Asn Pro Gln Ala  His Pro Tyr Phe Trp  Gln Cys Leu 
    1025                 1030                 1035             


Lys Asn  Ala Leu Ala Thr Asp  Asn His Val Thr Tyr  Ser Gln Val 
    1040                 1045                 1050             


Phe Lys  Glu Thr Ala 
    1055             


<210>  44
<211>  23
<212>  PRT
<213>  artificial

<220>
<223>  scarmbled C98i

<400>  44

Tyr Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg Cys Leu Val Pro Asn 
1               5                   10                  15      


Asp Cys Arg Leu Val Asn His 
            20              


<210>  45
<211>  4
<212>  PRT
<213>  artificial

<220>
<223>  C98i motif RCNC

<400>  45

Arg Cys Asn Cys 
1               


<210>  46
<211>  4
<212>  PRT
<213>  artificial

<220>
<223>  RANC

<400>  46

Arg Ala Asn Cys 
1               


<210>  47
<211>  4
<212>  PRT
<213>  artificial

<220>
<223>  RANA

<400>  47

Arg Ala Asn Ala 
1               


<210>  48
<211>  4
<212>  PRT
<213>  artificial

<220>
<223>  RCNA

<400>  48

Arg Cys Asn Ala 
1               


<210>  49
<211>  7
<212>  PRT
<213>  artificial

<220>
<223>  Homo sapiens TLR7

<400>  49

Asp Phe Arg Cys Asn Cys Val 
1               5           


<210>  50
<211>  7
<212>  PRT
<213>  artificial

<220>
<223>  Mus TLR7

<400>  50

Asp Leu Arg Cys Asn Cys Val 
1               5           


<210>  51
<211>  7
<212>  PRT
<213>  artificial

<220>
<223>  Rattus TLR7

<400>  51

Asp Leu Arg Cys Asn Cys Val 
1               5           


<210>  52
<211>  7
<212>  PRT
<213>  artificial

<220>
<223>  Pullum TLR7

<400>  52

Asp Leu Arg Cys Asn Cys Val 
1               5           


<210>  53
<211>  7
<212>  PRT
<213>  artificial

<220>
<223>  Ranae TLR7

<400>  53

Asp Phe Arg Cys Asn Cys Val 
1               5           


<210>  54
<211>  7
<212>  PRT
<213>  artificial

<220>
<223>  Porcus TLR7

<400>  54

Asp Phe Arg Cys Asn Cys Ile 
1               5           


<210>  55
<211>  7
<212>  PRT
<213>  artificial

<220>
<223>  Salmo TLR7

<400>  55

Asp Phe Arg Cys Asn Cys Ile 
1               5           


<210>  56
<211>  7
<212>  PRT
<213>  artificial

<220>
<223>  Danio rerio TLR7

<400>  56

Asp Leu Arg Cys Asn Cys Val 
1               5           


<210>  57
<211>  21
<212>  PRT
<213>  artificial

<220>
<223>  C98i with TAT

<400>  57

Tyr Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg Asp Leu Arg Cys Asn 
1               5                   10                  15      


Cys Val Pro Val Leu 
            20      


