Sequence Listing

<110>  University of Newcastle
 
<120>  Methods for diagnosing inflammatory phenotypes of chronic obstructive pulmonary disease

<130>  35256797

<160>  12    

<170>  PatentIn version 3.5

<210>  1
<211>  429
<212>  DNA
<213>  Homo sapiens

<400>  1
atgtccctgc tacccgtgcc atacacagag gctgcctctt tgtctactgg ttctactgtg     60

acaatcaaag ggcgaccact tgcctgtttc ttgaatgaac catatctgca ggtggatttc    120

cacactgaga tgaaggagga atcagacatt gtcttccatt tccaagtgtg ctttggtcgt    180

cgtgtggtca tgaacagccg tgagtatggg gcctggaagc agcaggtgga atccaagaat    240

atgccctttc aggatggcca agaatttgaa ctgagcatct cagtgctgcc agataagtac    300

caggtaatgg tcaatggcca atcctcttac acctttgacc atagaatcaa gcctgaggct    360

gtgaagatgg tgcaagtgtg gagagatatc tccctgacca aatttaatgt cagctattta    420

aagagataa                                                            429


<210>  2
<211>  142
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Ser Leu Leu Pro Val Pro Tyr Thr Glu Ala Ala Ser Leu Ser Thr 
1               5                   10                  15      


Gly Ser Thr Val Thr Ile Lys Gly Arg Pro Leu Ala Cys Phe Leu Asn 
            20                  25                  30          


Glu Pro Tyr Leu Gln Val Asp Phe His Thr Glu Met Lys Glu Glu Ser 
        35                  40                  45              


Asp Ile Val Phe His Phe Gln Val Cys Phe Gly Arg Arg Val Val Met 
    50                  55                  60                  


Asn Ser Arg Glu Tyr Gly Ala Trp Lys Gln Gln Val Glu Ser Lys Asn 
65                  70                  75                  80  


Met Pro Phe Gln Asp Gly Gln Glu Phe Glu Leu Ser Ile Ser Val Leu 
                85                  90                  95      


Pro Asp Lys Tyr Gln Val Met Val Asn Gly Gln Ser Ser Tyr Thr Phe 
            100                 105                 110         


Asp His Arg Ile Lys Pro Glu Ala Val Lys Met Val Gln Val Trp Arg 
        115                 120                 125             


Asp Ile Ser Leu Thr Lys Phe Asn Val Ser Tyr Leu Lys Arg 
    130                 135                 140         


<210>  3
<211>  1254
<212>  DNA
<213>  Homo sapiens

<400>  3
atgaggctca tcctgcctgt gggtttgatt gctaccactc ttgcaattgc tcctgtccgc     60

tttgacaggg agaaggtgtt ccgcgtgaag ccccaggatg aaaaacaagc agacatcata    120

aaggacttgg ccaaaaccaa tgagcttgac ttctggtatc caggtgccac ccaccacgta    180

gctgctaata tgatggtgga tttccgagtt agtgagaagg aatcccaagc catccagtct    240

gccttggatc aaaataaaat gcactatgaa atcttgattc atgatctaca agaagagatt    300

gagaaacagt ttgatgttaa agaagatatc ccaggcaggc acagctacgc aaaatacaat    360

aattgggaaa agattgtggc ttggactgaa aagatgatgg ataagtatcc tgaaatggtc    420

tctcgtatta aaattggatc tactgttgaa gataatccac tatatgttct gaagattggg    480

gaaaagaatg aaagaagaaa ggctattttt acggattgtg gcattcacgc acgagaatgg    540

gtctccccag cattctgcca gtggtttgtc tatcaggcaa ccaaaactta tgggagaaac    600

aaaattatga ccaaactctt ggaccgaatg aatttttaca ttcttcctgt gttcaatgtt    660

gatggatata tttggtcatg gacaaagaac cgcatgtgga gaaaaaatcg ttccaagaac    720

caaaactcca aatgcatcgg cactgacctc aacaggaatt ttaatgcttc atggaactcc    780

attcctaaca ccaatgaccc atgtgcagat aactatcggg gctctgcacc agagtccgag    840

aaagagacga aagctgtcac taatttcatt agaagccacc tgaatgaaat caaggtttac    900

atcaccttcc attcctactc ccagatgcta ttgtttccct atggatatac atcaaaactg    960

ccacctaacc atgaggactt ggccaaagtt gcaaagattg gcactgatgt tctatcaact   1020

cgatatgaaa cccgctacat ctatggccca atagaatcaa caatttaccc gatatcaggt   1080

tcttctttag actgggctta tgacctgggc atcaaacaca catttgcctt tgagctccga   1140

gataaaggca aatttggttt tctccttcca gaatcccgga taaagccaac gtgcagagag   1200

accatgctag ctgtcaaatt tattgccaag tatatcctca agcatacttc ctaa         1254


<210>  4
<211>  417
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Arg Leu Ile Leu Pro Val Gly Leu Ile Ala Thr Thr Leu Ala Ile 
1               5                   10                  15      


Ala Pro Val Arg Phe Asp Arg Glu Lys Val Phe Arg Val Lys Pro Gln 
            20                  25                  30          


Asp Glu Lys Gln Ala Asp Ile Ile Lys Asp Leu Ala Lys Thr Asn Glu 
        35                  40                  45              


Leu Asp Phe Trp Tyr Pro Gly Ala Thr His His Val Ala Ala Asn Met 
    50                  55                  60                  


Met Val Asp Phe Arg Val Ser Glu Lys Glu Ser Gln Ala Ile Gln Ser 
65                  70                  75                  80  


Ala Leu Asp Gln Asn Lys Met His Tyr Glu Ile Leu Ile His Asp Leu 
                85                  90                  95      


Gln Glu Glu Ile Glu Lys Gln Phe Asp Val Lys Glu Asp Ile Pro Gly 
            100                 105                 110         


Arg His Ser Tyr Ala Lys Tyr Asn Asn Trp Glu Lys Ile Val Ala Trp 
        115                 120                 125             


Thr Glu Lys Met Met Asp Lys Tyr Pro Glu Met Val Ser Arg Ile Lys 
    130                 135                 140                 


Ile Gly Ser Thr Val Glu Asp Asn Pro Leu Tyr Val Leu Lys Ile Gly 
145                 150                 155                 160 


Glu Lys Asn Glu Arg Arg Lys Ala Ile Phe Thr Asp Cys Gly Ile His 
                165                 170                 175     


Ala Arg Glu Trp Val Ser Pro Ala Phe Cys Gln Trp Phe Val Tyr Gln 
            180                 185                 190         


Ala Thr Lys Thr Tyr Gly Arg Asn Lys Ile Met Thr Lys Leu Leu Asp 
        195                 200                 205             


Arg Met Asn Phe Tyr Ile Leu Pro Val Phe Asn Val Asp Gly Tyr Ile 
    210                 215                 220                 


Trp Ser Trp Thr Lys Asn Arg Met Trp Arg Lys Asn Arg Ser Lys Asn 
225                 230                 235                 240 


Gln Asn Ser Lys Cys Ile Gly Thr Asp Leu Asn Arg Asn Phe Asn Ala 
                245                 250                 255     


Ser Trp Asn Ser Ile Pro Asn Thr Asn Asp Pro Cys Ala Asp Asn Tyr 
            260                 265                 270         


Arg Gly Ser Ala Pro Glu Ser Glu Lys Glu Thr Lys Ala Val Thr Asn 
        275                 280                 285             


Phe Ile Arg Ser His Leu Asn Glu Ile Lys Val Tyr Ile Thr Phe His 
    290                 295                 300                 


Ser Tyr Ser Gln Met Leu Leu Phe Pro Tyr Gly Tyr Thr Ser Lys Leu 
305                 310                 315                 320 


Pro Pro Asn His Glu Asp Leu Ala Lys Val Ala Lys Ile Gly Thr Asp 
                325                 330                 335     


Val Leu Ser Thr Arg Tyr Glu Thr Arg Tyr Ile Tyr Gly Pro Ile Glu 
            340                 345                 350         


Ser Thr Ile Tyr Pro Ile Ser Gly Ser Ser Leu Asp Trp Ala Tyr Asp 
        355                 360                 365             


Leu Gly Ile Lys His Thr Phe Ala Phe Glu Leu Arg Asp Lys Gly Lys 
    370                 375                 380                 


Phe Gly Phe Leu Leu Pro Glu Ser Arg Ile Lys Pro Thr Cys Arg Glu 
385                 390                 395                 400 


Thr Met Leu Ala Val Lys Phe Ile Ala Lys Tyr Ile Leu Lys His Thr 
                405                 410                 415     


Ser 
    


<210>  5
<211>  918
<212>  DNA
<213>  Homo sapiens

<400>  5
atgtcacggg agctggcccc actgctgctt ctcctcctct ccatccacag cgccctggcc     60

atgaggatct gctccttcaa cgtcaggtcc tttggggaaa gcaagcagga agacaagaat    120

gccatggatg tcattgtgaa ggtcatcaaa cgctgtgaca tcatactcgt gatggaaatc    180

aaggacagca acaacaggat ctgccccata ctgatggaga agctgaacag aaattcaagg    240

agaggcataa cgtacaacta tgtgattagc tctcggcttg gaagaaacac atataaagaa    300

caatatgcct ttctctacaa ggaaaagctg gtgtctgtga agaggagtta tcactaccat    360

gactatcagg atggagacgc agatgtgttt tccagggagc cctttgtggt ctggttccaa    420

tctccccaca ctgctgtcaa agacttcgtg attatccccc tgcacaccac cccagagaca    480

tccgttaagg agatcgatga gttggttgag gtctacacgg acgtgaaaca ccgctggaag    540

gcggagaatt tcattttcat gggtgacttc aatgccggct gcagctacgt ccccaagaag    600

gcctggaaga acatccgctt gaggactgac cccaggtttg tttggctgat cggggaccaa    660

gaggacacca cggtgaagaa gagcaccaac tgtgcatatg acaggattgt gcttagagga    720

caagaaatcg tcagttctgt tgttcccaag tcaaacagtg tttttgactt ccagaaagct    780

tacaagctga ctgaagagga ggccctggat gtcagcgacc actttccagt tgaatttaaa    840

ctacagtctt caagggcctt caccaacagc aaaaaatctg tcactctaag gaagaaaaca    900

aagagcaaac gctcctag                                                  918


<210>  6
<211>  305
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Ser Arg Glu Leu Ala Pro Leu Leu Leu Leu Leu Leu Ser Ile His 
1               5                   10                  15      


Ser Ala Leu Ala Met Arg Ile Cys Ser Phe Asn Val Arg Ser Phe Gly 
            20                  25                  30          


Glu Ser Lys Gln Glu Asp Lys Asn Ala Met Asp Val Ile Val Lys Val 
        35                  40                  45              


Ile Lys Arg Cys Asp Ile Ile Leu Val Met Glu Ile Lys Asp Ser Asn 
    50                  55                  60                  


Asn Arg Ile Cys Pro Ile Leu Met Glu Lys Leu Asn Arg Asn Ser Arg 
65                  70                  75                  80  


Arg Gly Ile Thr Tyr Asn Tyr Val Ile Ser Ser Arg Leu Gly Arg Asn 
                85                  90                  95      


Thr Tyr Lys Glu Gln Tyr Ala Phe Leu Tyr Lys Glu Lys Leu Val Ser 
            100                 105                 110         


Val Lys Arg Ser Tyr His Tyr His Asp Tyr Gln Asp Gly Asp Ala Asp 
        115                 120                 125             


Val Phe Ser Arg Glu Pro Phe Val Val Trp Phe Gln Ser Pro His Thr 
    130                 135                 140                 


Ala Val Lys Asp Phe Val Ile Ile Pro Leu His Thr Thr Pro Glu Thr 
145                 150                 155                 160 


Ser Val Lys Glu Ile Asp Glu Leu Val Glu Val Tyr Thr Asp Val Lys 
                165                 170                 175     


His Arg Trp Lys Ala Glu Asn Phe Ile Phe Met Gly Asp Phe Asn Ala 
            180                 185                 190         


Gly Cys Ser Tyr Val Pro Lys Lys Ala Trp Lys Asn Ile Arg Leu Arg 
        195                 200                 205             


Thr Asp Pro Arg Phe Val Trp Leu Ile Gly Asp Gln Glu Asp Thr Thr 
    210                 215                 220                 


Val Lys Lys Ser Thr Asn Cys Ala Tyr Asp Arg Ile Val Leu Arg Gly 
225                 230                 235                 240 


Gln Glu Ile Val Ser Ser Val Val Pro Lys Ser Asn Ser Val Phe Asp 
                245                 250                 255     


Phe Gln Lys Ala Tyr Lys Leu Thr Glu Glu Glu Ala Leu Asp Val Ser 
            260                 265                 270         


Asp His Phe Pro Val Glu Phe Lys Leu Gln Ser Ser Arg Ala Phe Thr 
        275                 280                 285             


Asn Ser Lys Lys Ser Val Thr Leu Arg Lys Lys Thr Lys Ser Lys Arg 
    290                 295                 300                 


Ser 
305 


<210>  7
<211>  810
<212>  DNA
<213>  Homo sapiens

<400>  7
atggcagaag tacctgagct cgccagtgaa atgatggctt attacagtgg caatgaggat     60

gacttgttct ttgaagctga tggccctaaa cagatgaagt gctccttcca ggacctggac    120

ctctgccctc tggatggcgg catccagcta cgaatctccg accaccacta cagcaagggc    180

ttcaggcagg ccgcgtcagt tgttgtggcc atggacaagc tgaggaagat gctggttccc    240

tgcccacaga ccttccagga gaatgacctg agcaccttct ttcccttcat ctttgaagaa    300

gaacctatct tcttcgacac atgggataac gaggcttatg tgcacgatgc acctgtacga    360

tcactgaact gcacgctccg ggactcacag caaaaaagct tggtgatgtc tggtccatat    420

gaactgaaag ctctccacct ccagggacag gatatggagc aacaagtggt gttctccatg    480

tcctttgtac aaggagaaga aagtaatgac aaaatacctg tggccttggg cctcaaggaa    540

aagaatctgt acctgtcctg cgtgttgaaa gatgataagc ccactctaca gctggagagt    600

gtagatccca aaaattaccc aaagaagaag atggaaaagc gatttgtctt caacaagata    660

gaaatcaata acaagctgga atttgagtct gcccagttcc ccaactggta catcagcacc    720

tctcaagcag aaaacatgcc cgtcttcctg ggagggacca aaggcggcca ggatataact    780

gacttcacca tgcaatttgt gtcttcctaa                                     810


<210>  8
<211>  269
<212>  PRT
<213>  Homo sapiens

<400>  8

Met Ala Glu Val Pro Glu Leu Ala Ser Glu Met Met Ala Tyr Tyr Ser 
1               5                   10                  15      


Gly Asn Glu Asp Asp Leu Phe Phe Glu Ala Asp Gly Pro Lys Gln Met 
            20                  25                  30          


Lys Cys Ser Phe Gln Asp Leu Asp Leu Cys Pro Leu Asp Gly Gly Ile 
        35                  40                  45              


Gln Leu Arg Ile Ser Asp His His Tyr Ser Lys Gly Phe Arg Gln Ala 
    50                  55                  60                  


Ala Ser Val Val Val Ala Met Asp Lys Leu Arg Lys Met Leu Val Pro 
65                  70                  75                  80  


Cys Pro Gln Thr Phe Gln Glu Asn Asp Leu Ser Thr Phe Phe Pro Phe 
                85                  90                  95      


Ile Phe Glu Glu Glu Pro Ile Phe Phe Asp Thr Trp Asp Asn Glu Ala 
            100                 105                 110         


Tyr Val His Asp Ala Pro Val Arg Ser Leu Asn Cys Thr Leu Arg Asp 
        115                 120                 125             


Ser Gln Gln Lys Ser Leu Val Met Ser Gly Pro Tyr Glu Leu Lys Ala 
    130                 135                 140                 


Leu His Leu Gln Gly Gln Asp Met Glu Gln Gln Val Val Phe Ser Met 
145                 150                 155                 160 


Ser Phe Val Gln Gly Glu Glu Ser Asn Asp Lys Ile Pro Val Ala Leu 
                165                 170                 175     


Gly Leu Lys Glu Lys Asn Leu Tyr Leu Ser Cys Val Leu Lys Asp Asp 
            180                 185                 190         


Lys Pro Thr Leu Gln Leu Glu Ser Val Asp Pro Lys Asn Tyr Pro Lys 
        195                 200                 205             


Lys Lys Met Glu Lys Arg Phe Val Phe Asn Lys Ile Glu Ile Asn Asn 
    210                 215                 220                 


Lys Leu Glu Phe Glu Ser Ala Gln Phe Pro Asn Trp Tyr Ile Ser Thr 
225                 230                 235                 240 


Ser Gln Ala Glu Asn Met Pro Val Phe Leu Gly Gly Thr Lys Gly Gly 
                245                 250                 255     


Gln Asp Ile Thr Asp Phe Thr Met Gln Phe Val Ser Ser 
            260                 265                 


<210>  9
<211>  1575
<212>  DNA
<213>  Homo sapiens

<400>  9
atgatttcac cattcttagt actggccatt ggcacctgcc ttactaactc cttagtgcca     60

gagaaagaga aagaccccaa gtactggcga gaccaagcgc aagagacact gaaatatgcc    120

ctggagcttc agaagctcaa caccaacgtg gctaagaatg tcatcatgtt cctgggagat    180

gggatgggtg tctccacagt gacggctgcc cgcatcctca agggtcagct ccaccacaac    240

cctggggagg agaccaggct ggagatggac aagttcccct tcgtggccct ctccaagacg    300

tacaacacca atgcccaggt ccctgacagc gccggcaccg ccaccgccta cctgtgtggg    360

gtgaaggcca atgagggcac cgtgggggta agcgcagcca ctgagcgttc ccggtgcaac    420

accacccagg ggaacgaggt cacctccatc ctgcgctggg ccaaggacgc tgggaaatct    480

gtgggcattg tgaccaccac gagagtgaac catgccaccc ccagcgccgc ctacgcccac    540

tcggctgacc gggactggta ctcagacaac gagatgcccc ctgaggcctt gagccagggc    600

tgtaaggaca tcgcctacca gctcatgcat aacatcaggg acattgacgt gatcatgggg    660

ggtggccgga aatacatgta ccccaagaat aaaactgatg tggagtatga gagtgacgag    720

aaagccaggg gcacgaggct ggacggcctg gacctcgttg acacctggaa gagcttcaaa    780

ccgagataca agcactccca cttcatctgg aaccgcacgg aactcctgac ccttgacccc    840

cacaatgtgg actacctatt gggtctcttc gagccagggg acatgcagta cgagctgaac    900

aggaacaacg tgacggaccc gtcactctcc gagatggtgg tggtggccat ccagatcctg    960

cggaagaacc ccaaaggctt cttcttgctg gtggaaggag gcagaattga ccacgggcac   1020

catgaaggaa aagccaagca ggccctgcat gaggcggtgg agatggaccg ggccatcggg   1080

caggcaggca gcttgacctc ctcggaagac actctgaccg tggtcactgc ggaccattcc   1140

cacgtcttca catttggtgg atacaccccc cgtggcaact ctatctttgg tctggccccc   1200

atgctgagtg acacagacaa gaagcccttc actgccatcc tgtatggcaa tgggcctggc   1260

tacaaggtgg tgggcggtga acgagagaat gtctccatgg tggactatgc tcacaacaac   1320

taccaggcgc agtctgctgt gcccctgcgc cacgagaccc acggcgggga ggacgtggcc   1380

gtcttctcca agggccccat ggcgcacctg ctgcacggcg tccacgagca gaactacgtc   1440

ccccacgtga tggcgtatgc agcctgcatc ggggccaacc tcggccactg tgctcctgcc   1500

agctcggcag gcagccttgc tgcaggcccc ctgctgctcg cgctggccct ctaccccctg   1560

agcgtcctgt tctga                                                    1575


<210>  10
<211>  524
<212>  PRT
<213>  Homo sapiens

<400>  10

Met Ile Ser Pro Phe Leu Val Leu Ala Ile Gly Thr Cys Leu Thr Asn 
1               5                   10                  15      


Ser Leu Val Pro Glu Lys Glu Lys Asp Pro Lys Tyr Trp Arg Asp Gln 
            20                  25                  30          


Ala Gln Glu Thr Leu Lys Tyr Ala Leu Glu Leu Gln Lys Leu Asn Thr 
        35                  40                  45              


Asn Val Ala Lys Asn Val Ile Met Phe Leu Gly Asp Gly Met Gly Val 
    50                  55                  60                  


Ser Thr Val Thr Ala Ala Arg Ile Leu Lys Gly Gln Leu His His Asn 
65                  70                  75                  80  


Pro Gly Glu Glu Thr Arg Leu Glu Met Asp Lys Phe Pro Phe Val Ala 
                85                  90                  95      


Leu Ser Lys Thr Tyr Asn Thr Asn Ala Gln Val Pro Asp Ser Ala Gly 
            100                 105                 110         


Thr Ala Thr Ala Tyr Leu Cys Gly Val Lys Ala Asn Glu Gly Thr Val 
        115                 120                 125             


Gly Val Ser Ala Ala Thr Glu Arg Ser Arg Cys Asn Thr Thr Gln Gly 
    130                 135                 140                 


Asn Glu Val Thr Ser Ile Leu Arg Trp Ala Lys Asp Ala Gly Lys Ser 
145                 150                 155                 160 


Val Gly Ile Val Thr Thr Thr Arg Val Asn His Ala Thr Pro Ser Ala 
                165                 170                 175     


Ala Tyr Ala His Ser Ala Asp Arg Asp Trp Tyr Ser Asp Asn Glu Met 
            180                 185                 190         


Pro Pro Glu Ala Leu Ser Gln Gly Cys Lys Asp Ile Ala Tyr Gln Leu 
        195                 200                 205             


Met His Asn Ile Arg Asp Ile Asp Val Ile Met Gly Gly Gly Arg Lys 
    210                 215                 220                 


Tyr Met Tyr Pro Lys Asn Lys Thr Asp Val Glu Tyr Glu Ser Asp Glu 
225                 230                 235                 240 


Lys Ala Arg Gly Thr Arg Leu Asp Gly Leu Asp Leu Val Asp Thr Trp 
                245                 250                 255     


Lys Ser Phe Lys Pro Arg Tyr Lys His Ser His Phe Ile Trp Asn Arg 
            260                 265                 270         


Thr Glu Leu Leu Thr Leu Asp Pro His Asn Val Asp Tyr Leu Leu Gly 
        275                 280                 285             


Leu Phe Glu Pro Gly Asp Met Gln Tyr Glu Leu Asn Arg Asn Asn Val 
    290                 295                 300                 


Thr Asp Pro Ser Leu Ser Glu Met Val Val Val Ala Ile Gln Ile Leu 
305                 310                 315                 320 


Arg Lys Asn Pro Lys Gly Phe Phe Leu Leu Val Glu Gly Gly Arg Ile 
                325                 330                 335     


Asp His Gly His His Glu Gly Lys Ala Lys Gln Ala Leu His Glu Ala 
            340                 345                 350         


Val Glu Met Asp Arg Ala Ile Gly Gln Ala Gly Ser Leu Thr Ser Ser 
        355                 360                 365             


Glu Asp Thr Leu Thr Val Val Thr Ala Asp His Ser His Val Phe Thr 
    370                 375                 380                 


Phe Gly Gly Tyr Thr Pro Arg Gly Asn Ser Ile Phe Gly Leu Ala Pro 
385                 390                 395                 400 


Met Leu Ser Asp Thr Asp Lys Lys Pro Phe Thr Ala Ile Leu Tyr Gly 
                405                 410                 415     


Asn Gly Pro Gly Tyr Lys Val Val Gly Gly Glu Arg Glu Asn Val Ser 
            420                 425                 430         


Met Val Asp Tyr Ala His Asn Asn Tyr Gln Ala Gln Ser Ala Val Pro 
        435                 440                 445             


Leu Arg His Glu Thr His Gly Gly Glu Asp Val Ala Val Phe Ser Lys 
    450                 455                 460                 


Gly Pro Met Ala His Leu Leu His Gly Val His Glu Gln Asn Tyr Val 
465                 470                 475                 480 


Pro His Val Met Ala Tyr Ala Ala Cys Ile Gly Ala Asn Leu Gly His 
                485                 490                 495     


Cys Ala Pro Ala Ser Ser Ala Gly Ser Leu Ala Ala Gly Pro Leu Leu 
            500                 505                 510         


Leu Ala Leu Ala Leu Tyr Pro Leu Ser Val Leu Phe 
        515                 520                 


<210>  11
<211>  1083
<212>  DNA
<213>  Homo sapiens

<400>  11
atggaagatt ttaacatgga gagtgacagc tttgaagatt tctggaaagg tgaagatctt     60

agtaattaca gttacagctc taccctgccc ccttttctac tagatgccgc cccatgtgaa    120

ccagaatccc tggaaatcaa caagtatttt gtggtcatta tctatgccct ggtattcctg    180

ctgagcctgc tgggaaactc cctcgtgatg ctggtcatct tatacagcag ggtcggccgc    240

tccgtcactg atgtctacct gctgaaccta gccttggccg acctactctt tgccctgacc    300

ttgcccatct gggccgcctc caaggtgaat ggctggattt ttggcacatt cctgtgcaag    360

gtggtctcac tcctgaagga agtcaacttc tatagtggca tcctgctact ggcctgcatc    420

agtgtggacc gttacctggc cattgtccat gccacacgca cactgaccca gaagcgctac    480

ttggtcaaat tcatatgtct cagcatctgg ggtctgtcct tgctcctggc cctgcctgtc    540

ttacttttcc gaaggaccgt ctactcatcc aatgttagcc cagcctgcta tgaggacatg    600

ggcaacaata cagcaaactg gcggatgctg ttacggatcc tgccccagtc ctttggcttc    660

atcgtgccac tgctgatcat gctgttctgc tacggattca ccctgcgtac gctgtttaag    720

gcccacatgg ggcagaagca ccgggccatg cgggtcatct ttgctgtcgt cctcatcttc    780

ctgctctgct ggctgcccta caacctggtc ctgctggcag acaccctcat gaggacccag    840

gtgatccagg agacctgtga gcgccgcaat cacatcgacc gggctctgga tgccaccgag    900

attctgggca tccttcacag ctgcctcaac cccctcatct acgccttcat tggccagaag    960

tttcgccatg gactcctcaa gattctagct atacatggct tgatcagcaa ggactccctg   1020

cccaaagaca gcaggccttc ctttgttggc tcttcttcag ggcacacttc cactactctc   1080

taa                                                                 1083


<210>  12
<211>  360
<212>  PRT
<213>  Homo sapiens

<400>  12

Met Glu Asp Phe Asn Met Glu Ser Asp Ser Phe Glu Asp Phe Trp Lys 
1               5                   10                  15      


Gly Glu Asp Leu Ser Asn Tyr Ser Tyr Ser Ser Thr Leu Pro Pro Phe 
            20                  25                  30          


Leu Leu Asp Ala Ala Pro Cys Glu Pro Glu Ser Leu Glu Ile Asn Lys 
        35                  40                  45              


Tyr Phe Val Val Ile Ile Tyr Ala Leu Val Phe Leu Leu Ser Leu Leu 
    50                  55                  60                  


Gly Asn Ser Leu Val Met Leu Val Ile Leu Tyr Ser Arg Val Gly Arg 
65                  70                  75                  80  


Ser Val Thr Asp Val Tyr Leu Leu Asn Leu Ala Leu Ala Asp Leu Leu 
                85                  90                  95      


Phe Ala Leu Thr Leu Pro Ile Trp Ala Ala Ser Lys Val Asn Gly Trp 
            100                 105                 110         


Ile Phe Gly Thr Phe Leu Cys Lys Val Val Ser Leu Leu Lys Glu Val 
        115                 120                 125             


Asn Phe Tyr Ser Gly Ile Leu Leu Leu Ala Cys Ile Ser Val Asp Arg 
    130                 135                 140                 


Tyr Leu Ala Ile Val His Ala Thr Arg Thr Leu Thr Gln Lys Arg Tyr 
145                 150                 155                 160 


Leu Val Lys Phe Ile Cys Leu Ser Ile Trp Gly Leu Ser Leu Leu Leu 
                165                 170                 175     


Ala Leu Pro Val Leu Leu Phe Arg Arg Thr Val Tyr Ser Ser Asn Val 
            180                 185                 190         


Ser Pro Ala Cys Tyr Glu Asp Met Gly Asn Asn Thr Ala Asn Trp Arg 
        195                 200                 205             


Met Leu Leu Arg Ile Leu Pro Gln Ser Phe Gly Phe Ile Val Pro Leu 
    210                 215                 220                 


Leu Ile Met Leu Phe Cys Tyr Gly Phe Thr Leu Arg Thr Leu Phe Lys 
225                 230                 235                 240 


Ala His Met Gly Gln Lys His Arg Ala Met Arg Val Ile Phe Ala Val 
                245                 250                 255     


Val Leu Ile Phe Leu Leu Cys Trp Leu Pro Tyr Asn Leu Val Leu Leu 
            260                 265                 270         


Ala Asp Thr Leu Met Arg Thr Gln Val Ile Gln Glu Thr Cys Glu Arg 
        275                 280                 285             


Arg Asn His Ile Asp Arg Ala Leu Asp Ala Thr Glu Ile Leu Gly Ile 
    290                 295                 300                 


Leu His Ser Cys Leu Asn Pro Leu Ile Tyr Ala Phe Ile Gly Gln Lys 
305                 310                 315                 320 


Phe Arg His Gly Leu Leu Lys Ile Leu Ala Ile His Gly Leu Ile Ser 
                325                 330                 335     


Lys Asp Ser Leu Pro Lys Asp Ser Arg Pro Ser Phe Val Gly Ser Ser 
            340                 345                 350         


Ser Gly His Thr Ser Thr Thr Leu 
        355                 360 




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