                         SEQUENCE LISTING

<110>  Development Center for Biotechnology
       DCB-USA LLC
 
<120>  A TARGET CELL-DEPENDENT T CELL ENGAGING AND ACTIVATION ASYMMETRIC
        HETERODIMERIC Fc-ScFv FUSION ANTIBODY FORMAT AND USES THEREOF IN
        CANCER THERAPY

<130>  DCB014-729US

<150>  US 62/523,279
<151>  2017-06-22

<160>  24    

<170>  PatentIn version 3.5

<210>  1
<211>  987
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1
gctagcacca agggcccttc cgtgttccct ctggcccctt ccagcaagtc tacctctggc       60

ggcaccgctg ctctgggctg cctcgtgaag gactacttcc ctgagcctgt gacagtgtcc      120

tggaactctg gcgccctgac ctccggcgtg cacaccttcc ctgccgtgct gcagtcctcc      180

ggcctgtact ctctgtcctc cgtcgtgaca gtgccttcct ccagcctggg cacccagacc      240

tacatctgca acgtgaacca caagccttcc aacaccaagg tggacaagaa ggtggagcct      300

aagtcctgcg acaagaccca cacctgtcct ccatgccctg cccctgaggc tgctggcgga      360

ccctccgtgt tcctgttccc tccaaagcct aaggacaccc tgatgatctc ccggacccct      420

gaagtgacct gcgtggtggt ggacgtgtcc cacgaggacc ctgaagtgaa gttcaattgg      480

tacgtggacg gcgtggaagt gcacaacgcc aagaccaagc ccagagagga acagtacaac      540

tccacctacc gggtggtgtc cgtgctgacc gtgctgcacc aggattggct gaacggcaaa      600

gagtacaagt gcaaggtgtc caacaaggcc ctgcctgccc ccatcgaaaa gaccatctcc      660

aaggccaagg gccagccccg ggaacctcaa gtgtgcaccc tgccccctag ccgggaagag      720

atgaccaaga accaggtgtc cctgtcctgc gccgtgaagg gcttctaccc ctccgacatt      780

gccgtggaat gggagtccaa cggccagcct gagaacaact acaagaccac cccccctgtg      840

ctggactccg acggctcatt cttcctggtg tccaagctga cagtggacaa gtcccggtgg      900

cagcagggca acgtgttctc ctgctccgtg atgcacgagg ccctgcacaa ccactacacc      960

cagaagtccc tgagcctgtc ccctggc                                          987


<210>  2
<211>  987
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2
gctagcacca agggcccttc cgtgttccct ctggcccctt ccagcaagtc tacctctggc       60

ggcaccgctg ctctgggctg cctcgtgaag gactacttcc ctgagcctgt gacagtgtcc      120

tggaactctg gcgccctgac ctccggcgtg cacaccttcc ctgccgtgct gcagtcctcc      180

ggcctgtact ctctgtcctc cgtcgtgaca gtgccttcct ccagcctggg cacccagacc      240

tacatctgca acgtgaacca caagccttcc aacaccaagg tggacaagaa ggtggagcct      300

aagtcctgcg acaagaccca cacctgtcct ccatgccctg cccctgaggc tgctggcgga      360

ccctccgtgt tcctgttccc tccaaagcct aaggacaccc tgatgatctc ccggacccct      420

gaagtgacct gcgtggtggt ggacgtgtcc cacgaggacc ctgaagtgaa gttcaattgg      480

tacgtggacg gcgtggaagt gcacaacgcc aagaccaagc ccagagagga acagtacaac      540

tccacctacc gggtggtgtc cgtgctgacc gtgctgcacc aggattggct gaacggcaaa      600

gagtacaagt gcaaggtgtc caacaaggcc ctgcctgccc ccatcgaaaa gaccatctcc      660

aaggccaagg gccagccccg ggaaccccag gtgtacacac tgcccccttg ccgggaagag      720

atgaccaaga accaggtgtc cctgtggtgc ctcgtgaagg gcttctaccc ctccgacatt      780

gccgtggaat gggagtccaa cggccagcct gagaacaact acaagaccac cccccctgtg      840

ctggactccg acggctcatt cttcctgtac tccaagctga cagtggacaa gtcccggtgg      900

cagcagggca acgtgttctc ctgctccgtg atgcacgagg ccctgcacaa ccactacacc      960

cagaagtccc tgtccctgag ccctggc                                          987


<210>  3
<211>  987
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3
gctagcacca agggcccttc cgtgttccct ctggcccctt ccagcaagtc tacctctggc       60

ggcaccgctg ctctgggctg cctcgtgaag gactacttcc ctgagcctgt gacagtgtcc      120

tggaactctg gcgccctgac ctccggcgtg cacaccttcc ctgccgtgct gcagtcctcc      180

ggcctgtact ctctgtcctc cgtcgtgaca gtgccttcct ccagcctggg cacccagacc      240

tacatctgca acgtgaacca caagccttcc aacaccaagg tggacaagaa ggtggagcct      300

aagtcctgcg acaagaccca cacctgtcct ccatgccctg cccctgagct ggctggcgct      360

ccctccgtgt tcctgttccc tccaaagcct aaggacaccc tgatgatctc ccggacccct      420

gaagtgacct gcgtggtggt ggacgtgtcc cacgaggacc ctgaagtgaa gttcaattgg      480

tacgtggacg gcgtggaagt gcacaacgcc aagaccaagc ccagagagga acagtacaac      540

tccacctacc gggtggtgtc cgtgctgacc gtgctgcacc aggattggct gaacggcaaa      600

gagtacaagt gcaaggtgtc caacaaggcc ctgcctgccc ccatcgaaaa gaccatctcc      660

aaggccaagg gccagccccg ggaacctcaa gtgtgcaccc tgccccctag ccgggaagag      720

atgaccaaga accaggtgtc cctgtcctgc gccgtgaagg gcttctaccc ctccgacatt      780

gccgtggaat gggagtccaa cggccagcct gagaacaact acaagaccac cccccctgtg      840

ctggactccg acggctcatt cttcctggtg tccaagctga cagtggacaa gtcccggtgg      900

cagcagggca acgtgttctc ctgctccgtg atgcacgagg ccctgcacaa ccactacacc      960

cagaagtccc tgagcctgtc ccctggc                                          987


<210>  4
<211>  987
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  4
gctagcacca agggcccttc cgtgttccct ctggcccctt ccagcaagtc tacctctggc       60

ggcaccgctg ctctgggctg cctcgtgaag gactacttcc ctgagcctgt gacagtgtcc      120

tggaactctg gcgccctgac ctccggcgtg cacaccttcc ctgccgtgct gcagtcctcc      180

ggcctgtact ctctgtcctc cgtcgtgaca gtgccttcct ccagcctggg cacccagacc      240

tacatctgca acgtgaacca caagccttcc aacaccaagg tggacaagaa ggtggagcct      300

aagtcctgcg acaagaccca cacctgtcct ccatgccctg cccctgagct ggctggcgct      360

ccctccgtgt tcctgttccc tccaaagcct aaggacaccc tgatgatctc ccggacccct      420

gaagtgacct gcgtggtggt ggacgtgtcc cacgaggacc ctgaagtgaa gttcaattgg      480

tacgtggacg gcgtggaagt gcacaacgcc aagaccaagc ccagagagga acagtacaac      540

tccacctacc gggtggtgtc cgtgctgacc gtgctgcacc aggattggct gaacggcaaa      600

gagtacaagt gcaaggtgtc caacaaggcc ctgcctgccc ccatcgaaaa gaccatctcc      660

aaggccaagg gccagccccg ggaaccccag gtgtacacac tgcccccttg ccgggaagag      720

atgaccaaga accaggtgtc cctgtggtgc ctcgtgaagg gcttctaccc ctccgacatt      780

gccgtggaat gggagtccaa cggccagcct gagaacaact acaagaccac cccccctgtg      840

ctggactccg acggctcatt cttcctgtac tccaagctga cagtggacaa gtcccggtgg      900

cagcagggca acgtgttctc ctgctccgtg atgcacgagg ccctgcacaa ccactacacc      960

cagaagtccc tgtccctgag ccctggc                                          987


<210>  5
<211>  345
<212>  DNA
<213>  Mus musculus

<400>  5
gagatccagc tggtgcagtc tggcggagga ctggctcagc ctggcggctc tatcagactg       60

agctgtgccc ccagcggcta catcagcagc gaccagatcc tgaactgggt caagaaggcc      120

cctggcaagg gcctggaatg gatcggcaga atctaccccg tgaccggcgt gacccagtac      180

aaccacaagt tcgtgggcaa ggccaccttc agcgtggaca gatccaagga caccgtgtac      240

atgcagatga acagcctgag agccgaggac accggcgtgt actactgcgg cagaggcgag      300

acattcgaca gctggggcca gggcacactg ctgaccgtgt catct                      345


<210>  6
<211>  342
<212>  DNA
<213>  Mus musculus

<400>  6
gacatccagc tgacccagag catcagcagc ctgagcgtgt ccgtgggcga cagagtgacc       60

atcaactgca agagcaacca gaacctgctg tggagcggca acagacggta caccctcgtg      120

tggcaccagt ggaagcctgg caagagcccc aagcccctga tcacatgggc cagcgacaga      180

tccttcggcg tgcccagcag attcagcggc agcggctctg tgaccgactt caccctgacc      240

atcagctccg tgcagcccga ggacttcgcc gtgtacttct gccagcagca cctggacatc      300

ccttacacct tcggcggagg caccaagctg gaaatcaaga ga                         342


<210>  7
<211>  732
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  7
gacatccagc tgacccagag catcagcagc ctgagcgtgt ccgtgggcga cagagtgacc       60

atcaactgca agagcaacca gaacctgctg tggagcggca acagacggta caccctcgtg      120

tggcaccagt ggaagcctgg caagagcccc aagcccctga tcacatgggc cagcgacaga      180

tccttcggcg tgcccagcag attcagcggc agcggctctg tgaccgactt caccctgacc      240

atcagctccg tgcagcccga ggacttcgcc gtgtacttct gccagcagca cctggacatc      300

ccttacacct tcggcggagg caccaagctg gaaatcaaga gatgtggagg cggttcaggc      360

ggaggtggct ctggcggtgg cggatcggag atccagctgg tgcagtctgg cggaggactg      420

gctcagcctg gcggctctat cagactgagc tgtgccccca gcggctacat cagcagcgac      480

cagatcctga actgggtcaa gaaggcccct ggcaagggcc tggaatggat cggcagaatc      540

taccccgtga ccggcgtgac ccagtacaac cacaagttcg tgggcaaggc caccttcagc      600

gtggacagat ccaaggacac cgtgtacatg cagatgaaca gcctgagagc cgaggacacc      660

ggcgtgtact actgcggcag aggcgagaca ttcgacagct ggggccaggg cacactgctg      720

accgtgtcat ct                                                          732


<210>  8
<211>  744
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  8
gatatccaga tgacccagtc cccctcctcc ctgtctgcct ccgtgggcga cagagtgacc       60

atcacctgtc gggcctccca ggatgtgaac accgccgtgg cctggtatca gcagaagcct      120

ggcaaggccc ctaagctgct gatctactcc gcctccttcc tgtactccgg cgtgccctcc      180

cggttctccg gctctagatc cggcacagac ttcaccctga ccatctccag cctgcagcct      240

gaggacttcg ccacctacta ctgccagcag cactacacca cccctccaac cttcggccag      300

ggcaccaagg tggagatcaa gcggtgtgga ggcggtagcg gcggaggagg atccgggggc      360

ggcgggtccg gcggtggcgg aagcgaggtg cagctggtgg agtctggggg aggactggtg      420

cagcctggcg gctccctgag actgtcttgc gctgctagcg gcttcaacat caaggacacc      480

tacatccact gggttcgcca ggctccaggc aagggactgg aatgggtggc ccggatctac      540

cctaccaacg gctacaccag atacgccgac tccgtgaagg gccggttcac catctccgcc      600

gacacctcca agaacaccgc ctacctgcag atgaactccc tgagggccga ggacaccgcc      660

gtgtactact gctccagatg gggaggcgac ggcttctacg ccatggacta ctggggccag      720

ggcaccctgg ttaccgtgtc ctcc                                             744


<210>  9
<211>  159
<212>  DNA
<213>  Homo sapiens

<400>  9
aatagcgata gcgagtgccc tctgagccac gacggctact gtctgcatga tggcgtgtgc       60

atgtacatcg aggccctgga taagtacgcc tgcaactgcg tcgtgggcta catcggagag      120

agatgccagt accgggacct gaagtggtgg gagcttaga                             159


<210>  10
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  10
atgggtgccc agcaagagga atgcgaatgg gacccttgga cctgcgagca catgcttgaa       60


<210>  11
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  11
tctatggacc cattcctgtt tcagctgctg cagctc                                 36


<210>  12
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  12
atgcctcatc ctaccaagaa cttcgacctg tacgtg                                 36


<210>  13
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  13
ggcggaggcg gaggatctgg tggtggtgga tctggcggcg gaggaagt                    48


<210>  14
<211>  723
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  14
caggtgcagc tggtgcagag cggcgctgaa gtgaagaaac ctggcgcctc cgtgaaggtg       60

tcctgcaagg cttctggcta cacctttacc cggtacacca tgcattgggt gcgacaggct      120

ccaggccagg ggctggaatg gattggctac atcaacccca gccggggcta caccaactac      180

aatcagaagt tcaaggataa ggccaccctg accaccgaca agtccatctc caccgcctac      240

atggaactgt cccggctgag atccgacgat accgctgtgt actactgcgc ccggtactac      300

gacgaccact acaccctgga ctactgggga cagggtactc tcgtgactgt gtcaagtggc      360

ggtggtggta gtggcggggg aggttcaggg gggggaggaa gcgaaatcgt gctgacacag      420

agccccgcca ccctgtcact gtctccaggc gagagagcta ccctgagctg ctctgcctcc      480

tcctccgtgt cttacatgaa ctggtatcag cagaagcccg gccaggcccc cagacggtgg      540

atctacgata cctccaagct ggcctccggc atccctgcca gattctccgg ctctggctcc      600

ggcacctcct ataccctgac aatctccagc ctggaacccg aggactttgc cgtgtattac      660

tgccagcagt ggtcctccaa ccccttcacc ttcggacagg gcacaaaggt ggaaatcaag      720

cgc                                                                    723


<210>  15
<211>  329
<212>  PRT
<213>  Artificial Sequeence

<220>
<223>  Synthetic

<400>  15

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Cys Thr Leu Pro Pro Ser Arg Glu Glu 
225                 230                 235                 240 


Met Thr Lys Asn Gln Val Ser Leu Ser Cys Ala Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Val Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly 
                325                 


<210>  16
<211>  329
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  16

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Cys Arg Glu Glu 
225                 230                 235                 240 


Met Thr Lys Asn Gln Val Ser Leu Trp Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly 
                325                 


<210>  17
<211>  329
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  17

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Ala Gly Ala Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Cys Thr Leu Pro Pro Ser Arg Glu Glu 
225                 230                 235                 240 


Met Thr Lys Asn Gln Val Ser Leu Ser Cys Ala Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Val Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly 
                325                 


<210>  18
<211>  329
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  18

Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val 
1               5                   10                  15      


Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys 
            20                  25                  30          


Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu 
        35                  40                  45              


Ala Gly Ala Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Ala 
    50                  55                  60                  


Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser 
65                  70                  75                  80  


Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe 
                85                  90                  95      


Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly 
            100                 105                 110         


Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu 
        115                 120                 125             


Ser Ser Val Val Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Cys Arg Glu Glu 
225                 230                 235                 240 


Met Thr Lys Asn Gln Val Ser Leu Trp Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly 
                325                 


<210>  19
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  19

Met Gly Ala Gln Gln Glu Glu Cys Glu Trp Asp Pro Trp Thr Cys Glu 
1               5                   10                  15      


His Met Leu Glu 
            20  


<210>  20
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  20

Ser Met Asp Pro Phe Leu Phe Gln Leu Leu Gln Leu 
1               5                   10          


<210>  21
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  21

Met Pro His Pro Thr Lys Asn Phe Asp Leu Tyr Val 
1               5                   10          


<210>  22
<211>  53
<212>  PRT
<213>  Homo sapiens

<400>  22

Asn Ser Asp Ser Glu Cys Pro Leu Ser His Asp Gly Tyr Cys Leu His 
1               5                   10                  15      


Asp Gly Val Cys Met Tyr Ile Glu Ala Leu Asp Lys Tyr Ala Cys Asn 
            20                  25                  30          


Cys Val Val Gly Tyr Ile Gly Glu Arg Cys Gln Tyr Arg Asp Leu Lys 
        35                  40                  45              


Trp Trp Glu Leu Arg 
    50              


<210>  23
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  23

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  24
<211>  241
<212>  PRT
<213>  Mus musculus

<400>  24

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Arg Tyr 
            20                  25                  30          


Thr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Pro Ser Arg Gly Tyr Thr Asn Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asp Lys Ala Thr Leu Thr Thr Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Tyr Tyr Asp Asp His Tyr Thr Leu Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Glu Ile Val Leu Thr Gln Ser Pro Ala Thr 
    130                 135                 140                 


Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Ser Ala Ser 
145                 150                 155                 160 


Ser Ser Val Ser Tyr Met Asn Trp Tyr Gln Gln Lys Pro Gly Gln Ala 
                165                 170                 175     


Pro Arg Arg Trp Ile Tyr Asp Thr Ser Lys Leu Ala Ser Gly Ile Pro 
            180                 185                 190         


Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Thr Leu Thr Ile 
        195                 200                 205             


Ser Ser Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Trp 
    210                 215                 220                 


Ser Ser Asn Pro Phe Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
225                 230                 235                 240 


Arg 
    


