                               SEQUENCE LISTING

<110> THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR 
      UNIVERSITY
 
<120> PDE5A DESTABILIZING DOMAINS

<130> 091511-0624/8285.WO00

<140>
<141>

<150> 62/524,384
<151> 2017-06-23

<160> 77    

<170> PatentIn version 3.5

<210> 1
<211> 875
<212> PRT
<213> Homo sapiens

<400> 1
Met Glu Arg Ala Gly Pro Ser Phe Gly Gln Gln Arg Gln Gln Gln Gln 
1               5                   10                  15      


Pro Gln Gln Gln Lys Gln Gln Gln Arg Asp Gln Asp Ser Val Glu Ala 
            20                  25                  30          


Trp Leu Asp Asp His Trp Asp Phe Thr Phe Ser Tyr Phe Val Arg Lys 
        35                  40                  45              


Ala Thr Arg Glu Met Val Asn Ala Trp Phe Ala Glu Arg Val His Thr 
    50                  55                  60                  


Ile Pro Val Cys Lys Glu Gly Ile Arg Gly His Thr Glu Ser Cys Ser 
65                  70                  75                  80  


Cys Pro Leu Gln Gln Ser Pro Arg Ala Asp Asn Ser Ala Pro Gly Thr 
                85                  90                  95      


Pro Thr Arg Lys Ile Ser Ala Ser Glu Phe Asp Arg Pro Leu Arg Pro 
            100                 105                 110         


Ile Val Val Lys Asp Ser Glu Gly Thr Val Ser Phe Leu Ser Asp Ser 
        115                 120                 125             


Glu Lys Lys Glu Gln Met Pro Leu Thr Pro Pro Arg Phe Asp His Asp 
    130                 135                 140                 


Glu Gly Asp Gln Cys Ser Arg Leu Leu Glu Leu Val Lys Asp Ile Ser 
145                 150                 155                 160 


Ser His Leu Asp Val Thr Ala Leu Cys His Lys Ile Phe Leu His Ile 
                165                 170                 175     


His Gly Leu Ile Ser Ala Asp Arg Tyr Ser Leu Phe Leu Val Cys Glu 
            180                 185                 190         


Asp Ser Ser Asn Asp Lys Phe Leu Ile Ser Arg Leu Phe Asp Val Ala 
        195                 200                 205             


Glu Gly Ser Thr Leu Glu Glu Val Ser Asn Asn Cys Ile Arg Leu Glu 
    210                 215                 220                 


Trp Asn Lys Gly Ile Val Gly His Val Ala Ala Leu Gly Glu Pro Leu 
225                 230                 235                 240 


Asn Ile Lys Asp Ala Tyr Glu Asp Pro Arg Phe Asn Ala Glu Val Asp 
                245                 250                 255     


Gln Ile Thr Gly Tyr Lys Thr Gln Ser Ile Leu Cys Met Pro Ile Lys 
            260                 265                 270         


Asn His Arg Glu Glu Val Val Gly Val Ala Gln Ala Ile Asn Lys Lys 
        275                 280                 285             


Ser Gly Asn Gly Gly Thr Phe Thr Glu Lys Asp Glu Lys Asp Phe Ala 
    290                 295                 300                 


Ala Tyr Leu Ala Phe Cys Gly Ile Val Leu His Asn Ala Gln Leu Tyr 
305                 310                 315                 320 


Glu Thr Ser Leu Leu Glu Asn Lys Arg Asn Gln Val Leu Leu Asp Leu 
                325                 330                 335     


Ala Ser Leu Ile Phe Glu Glu Gln Gln Ser Leu Glu Val Ile Leu Lys 
            340                 345                 350         


Lys Ile Ala Ala Thr Ile Ile Ser Phe Met Gln Val Gln Lys Cys Thr 
        355                 360                 365             


Ile Phe Ile Val Asp Glu Asp Cys Ser Asp Ser Phe Ser Ser Val Phe 
    370                 375                 380                 


His Met Glu Cys Glu Glu Leu Glu Lys Ser Ser Asp Thr Leu Thr Arg 
385                 390                 395                 400 


Glu His Asp Ala Asn Lys Ile Asn Tyr Met Tyr Ala Gln Tyr Val Lys 
                405                 410                 415     


Asn Thr Met Glu Pro Leu Asn Ile Pro Asp Val Ser Lys Asp Lys Arg 
            420                 425                 430         


Phe Pro Trp Thr Thr Glu Asn Thr Gly Asn Val Asn Gln Gln Cys Ile 
        435                 440                 445             


Arg Ser Leu Leu Cys Thr Pro Ile Lys Asn Gly Lys Lys Asn Lys Val 
    450                 455                 460                 


Ile Gly Val Cys Gln Leu Val Asn Lys Met Glu Glu Asn Thr Gly Lys 
465                 470                 475                 480 


Val Lys Pro Phe Asn Arg Asn Asp Glu Gln Phe Leu Glu Ala Phe Val 
                485                 490                 495     


Ile Phe Cys Gly Leu Gly Ile Gln Asn Thr Gln Met Tyr Glu Ala Val 
            500                 505                 510         


Glu Arg Ala Met Ala Lys Gln Met Val Thr Leu Glu Val Leu Ser Tyr 
        515                 520                 525             


His Ala Ser Ala Ala Glu Glu Glu Thr Arg Glu Leu Gln Ser Leu Ala 
    530                 535                 540                 


Ala Ala Val Val Pro Ser Ala Gln Thr Leu Lys Ile Thr Asp Phe Ser 
545                 550                 555                 560 


Phe Ser Asp Phe Glu Leu Ser Asp Leu Glu Thr Ala Leu Cys Thr Ile 
                565                 570                 575     


Arg Met Phe Thr Asp Leu Asn Leu Val Gln Asn Phe Gln Met Lys His 
            580                 585                 590         


Glu Val Leu Cys Arg Trp Ile Leu Ser Val Lys Lys Asn Tyr Arg Lys 
        595                 600                 605             


Asn Val Ala Tyr His Asn Trp Arg His Ala Phe Asn Thr Ala Gln Cys 
    610                 615                 620                 


Met Phe Ala Ala Leu Lys Ala Gly Lys Ile Gln Asn Lys Leu Thr Asp 
625                 630                 635                 640 


Leu Glu Ile Leu Ala Leu Leu Ile Ala Ala Leu Ser His Asp Leu Asp 
                645                 650                 655     


His Arg Gly Val Asn Asn Ser Tyr Ile Gln Arg Ser Glu His Pro Leu 
            660                 665                 670         


Ala Gln Leu Tyr Cys His Ser Ile Met Glu His His His Phe Asp Gln 
        675                 680                 685             


Cys Leu Met Ile Leu Asn Ser Pro Gly Asn Gln Ile Leu Ser Gly Leu 
    690                 695                 700                 


Ser Ile Glu Glu Tyr Lys Thr Thr Leu Lys Ile Ile Lys Gln Ala Ile 
705                 710                 715                 720 


Leu Ala Thr Asp Leu Ala Leu Tyr Ile Lys Arg Arg Gly Glu Phe Phe 
                725                 730                 735     


Glu Leu Ile Arg Lys Asn Gln Phe Asn Leu Glu Asp Pro His Gln Lys 
            740                 745                 750         


Glu Leu Phe Leu Ala Met Leu Met Thr Ala Cys Asp Leu Ser Ala Ile 
        755                 760                 765             


Thr Lys Pro Trp Pro Ile Gln Gln Arg Ile Ala Glu Leu Val Ala Thr 
    770                 775                 780                 


Glu Phe Phe Asp Gln Gly Asp Arg Glu Arg Lys Glu Leu Asn Ile Glu 
785                 790                 795                 800 


Pro Thr Asp Leu Met Asn Arg Glu Lys Lys Asn Lys Ile Pro Ser Met 
                805                 810                 815     


Gln Val Gly Phe Ile Asp Ala Ile Cys Leu Gln Leu Tyr Glu Ala Leu 
            820                 825                 830         


Thr His Val Ser Glu Asp Cys Phe Pro Leu Leu Asp Gly Cys Arg Lys 
        835                 840                 845             


Asn Arg Gln Lys Trp Gln Ala Leu Ala Glu Gln Gln Glu Lys Met Leu 
    850                 855                 860                 


Ile Asn Gly Glu Ser Gly Gln Ala Lys Arg Asn 
865                 870                 875 


<210> 2
<211> 2628
<212> DNA
<213> Homo sapiens

<400> 2
atggagcggg ccggccccag cttcgggcag cagcgacagc agcagcagcc ccagcagcag       60

aagcagcagc agagggatca ggactcggtc gaagcatggc tggacgatca ctgggacttt      120

accttctcat actttgttag aaaagccacc agagaaatgg tcaatgcatg gtttgctgag      180

agagttcaca ccatccctgt gtgcaaggaa ggtatcagag gccacaccga atcttgctct      240

tgtcccttgc agcagagtcc tcgtgcagat aacagtgccc ctggaacacc aaccaggaaa      300

atctctgcct ctgaatttga ccggcctctt agacccattg ttgtcaagga ttctgaggga      360

actgtgagct tcctctctga ctcagaaaag aaggaacaga tgcctctaac ccctccaagg      420

tttgatcatg atgaagggga ccagtgctca agactcttgg aattagtgaa ggatatttct      480

agtcatttgg atgtcacagc cttatgtcac aaaattttct tgcatatcca tggactgata      540

tctgctgacc gctattccct gttccttgtc tgtgaagaca gctccaatga caagtttctt      600

atcagccgcc tctttgatgt tgctgaaggt tcaacactgg aagaagtttc aaataactgt      660

atccgcttag aatggaacaa aggcattgtg ggacatgtgg cagcgcttgg tgagcccttg      720

aacatcaaag atgcatatga ggatcctcgg ttcaatgcag aagttgacca aattacaggc      780

tacaagacac aaagcattct ttgtatgcca attaagaatc atagggaaga ggttgttggt      840

gtagcccagg ccatcaacaa gaaatcagga aacggtggga catttactga aaaagatgaa      900

aaggactttg ctgcttattt ggcattttgt ggtattgttc ttcataatgc tcagctctat      960

gagacttcac tgctggagaa caagagaaat caggtgctgc ttgaccttgc tagtttaatt     1020

tttgaagaac aacaatcatt agaagtaatt ttgaagaaaa tagctgccac tattatctct     1080

ttcatgcaag tgcagaaatg caccattttc atagtggatg aagattgctc cgattctttt     1140

tctagtgtgt ttcacatgga gtgtgaggaa ttagaaaaat catctgatac attaacaagg     1200

gaacatgatg caaacaaaat caattacatg tatgctcagt atgtcaaaaa tactatggaa     1260

ccacttaata tcccagatgt cagtaaggat aaaagatttc cctggacaac tgaaaataca     1320

ggaaatgtaa accagcagtg cattagaagt ttgctttgta cacctataaa aaatggaaag     1380

aagaataaag ttataggggt ttgccaactt gttaataaga tggaggagaa tactggcaag     1440

gttaagcctt tcaaccgaaa tgacgaacag tttctggaag cttttgtcat cttttgtggc     1500

ttggggatcc agaacacgca gatgtatgaa gcagtggaga gagccatggc caagcaaatg     1560

gtcacattgg aggttctgtc gtatcatgct tcagcagcag aggaagaaac aagagagcta     1620

cagtcgttag cggctgctgt ggtgccatct gcccagaccc ttaaaattac tgactttagc     1680

ttcagtgact ttgagctgtc tgatctggaa acagcactgt gtacaattcg gatgtttact     1740

gacctcaacc ttgtgcagaa cttccagatg aaacatgagg ttctttgcag atggatttta     1800

agtgttaaga agaattatcg gaagaatgtt gcctatcata attggagaca tgcctttaat     1860

acagctcagt gcatgtttgc tgctctaaaa gcaggcaaaa ttcagaacaa gctgactgac     1920

ctggagatac ttgcattgct gattgctgca ctaagccacg atttggatca ccgtggtgtg     1980

aataactctt acatacagcg aagtgaacat ccacttgccc agctttactg ccattcaatc     2040

atggaacacc atcattttga ccagtgcctg atgattctta atagtccagg caatcagatt     2100

ctcagtggcc tctccattga agaatataag accacgttga aaataatcaa gcaagctatt     2160

ttagctacag acctagcact gtacattaag aggcgaggag aattttttga acttataaga     2220

aaaaatcaat tcaatttgga agatcctcat caaaaggagt tgtttttggc aatgctgatg     2280

acagcttgtg atctttctgc aattacaaaa ccctggccta ttcaacaacg gatagcagaa     2340

cttgtagcaa ctgaattttt tgatcaagga gacagagaga gaaaagaact caacatagaa     2400

cccactgatc taatgaacag ggagaagaaa aacaaaatcc caagtatgca agttgggttc     2460

atagatgcca tctgcttgca actgtatgag gccctgaccc acgtgtcaga ggactgtttc     2520

cctttgctag atggctgcag aaagaacagg cagaaatggc aggcccttgc agaacagcag     2580

gagaagatgc tgattaatgg ggaaagcggc caggccaagc ggaactga                  2628


<210> 3
<211> 833
<212> PRT
<213> Homo sapiens

<400> 3
Met Leu Pro Phe Gly Asp Lys Thr Arg Glu Met Val Asn Ala Trp Phe 
1               5                   10                  15      


Ala Glu Arg Val His Thr Ile Pro Val Cys Lys Glu Gly Ile Arg Gly 
            20                  25                  30          


His Thr Glu Ser Cys Ser Cys Pro Leu Gln Gln Ser Pro Arg Ala Asp 
        35                  40                  45              


Asn Ser Ala Pro Gly Thr Pro Thr Arg Lys Ile Ser Ala Ser Glu Phe 
    50                  55                  60                  


Asp Arg Pro Leu Arg Pro Ile Val Val Lys Asp Ser Glu Gly Thr Val 
65                  70                  75                  80  


Ser Phe Leu Ser Asp Ser Glu Lys Lys Glu Gln Met Pro Leu Thr Pro 
                85                  90                  95      


Pro Arg Phe Asp His Asp Glu Gly Asp Gln Cys Ser Arg Leu Leu Glu 
            100                 105                 110         


Leu Val Lys Asp Ile Ser Ser His Leu Asp Val Thr Ala Leu Cys His 
        115                 120                 125             


Lys Ile Phe Leu His Ile His Gly Leu Ile Ser Ala Asp Arg Tyr Ser 
    130                 135                 140                 


Leu Phe Leu Val Cys Glu Asp Ser Ser Asn Asp Lys Phe Leu Ile Ser 
145                 150                 155                 160 


Arg Leu Phe Asp Val Ala Glu Gly Ser Thr Leu Glu Glu Val Ser Asn 
                165                 170                 175     


Asn Cys Ile Arg Leu Glu Trp Asn Lys Gly Ile Val Gly His Val Ala 
            180                 185                 190         


Ala Leu Gly Glu Pro Leu Asn Ile Lys Asp Ala Tyr Glu Asp Pro Arg 
        195                 200                 205             


Phe Asn Ala Glu Val Asp Gln Ile Thr Gly Tyr Lys Thr Gln Ser Ile 
    210                 215                 220                 


Leu Cys Met Pro Ile Lys Asn His Arg Glu Glu Val Val Gly Val Ala 
225                 230                 235                 240 


Gln Ala Ile Asn Lys Lys Ser Gly Asn Gly Gly Thr Phe Thr Glu Lys 
                245                 250                 255     


Asp Glu Lys Asp Phe Ala Ala Tyr Leu Ala Phe Cys Gly Ile Val Leu 
            260                 265                 270         


His Asn Ala Gln Leu Tyr Glu Thr Ser Leu Leu Glu Asn Lys Arg Asn 
        275                 280                 285             


Gln Val Leu Leu Asp Leu Ala Ser Leu Ile Phe Glu Glu Gln Gln Ser 
    290                 295                 300                 


Leu Glu Val Ile Leu Lys Lys Ile Ala Ala Thr Ile Ile Ser Phe Met 
305                 310                 315                 320 


Gln Val Gln Lys Cys Thr Ile Phe Ile Val Asp Glu Asp Cys Ser Asp 
                325                 330                 335     


Ser Phe Ser Ser Val Phe His Met Glu Cys Glu Glu Leu Glu Lys Ser 
            340                 345                 350         


Ser Asp Thr Leu Thr Arg Glu His Asp Ala Asn Lys Ile Asn Tyr Met 
        355                 360                 365             


Tyr Ala Gln Tyr Val Lys Asn Thr Met Glu Pro Leu Asn Ile Pro Asp 
    370                 375                 380                 


Val Ser Lys Asp Lys Arg Phe Pro Trp Thr Thr Glu Asn Thr Gly Asn 
385                 390                 395                 400 


Val Asn Gln Gln Cys Ile Arg Ser Leu Leu Cys Thr Pro Ile Lys Asn 
                405                 410                 415     


Gly Lys Lys Asn Lys Val Ile Gly Val Cys Gln Leu Val Asn Lys Met 
            420                 425                 430         


Glu Glu Asn Thr Gly Lys Val Lys Pro Phe Asn Arg Asn Asp Glu Gln 
        435                 440                 445             


Phe Leu Glu Ala Phe Val Ile Phe Cys Gly Leu Gly Ile Gln Asn Thr 
    450                 455                 460                 


Gln Met Tyr Glu Ala Val Glu Arg Ala Met Ala Lys Gln Met Val Thr 
465                 470                 475                 480 


Leu Glu Val Leu Ser Tyr His Ala Ser Ala Ala Glu Glu Glu Thr Arg 
                485                 490                 495     


Glu Leu Gln Ser Leu Ala Ala Ala Val Val Pro Ser Ala Gln Thr Leu 
            500                 505                 510         


Lys Ile Thr Asp Phe Ser Phe Ser Asp Phe Glu Leu Ser Asp Leu Glu 
        515                 520                 525             


Thr Ala Leu Cys Thr Ile Arg Met Phe Thr Asp Leu Asn Leu Val Gln 
    530                 535                 540                 


Asn Phe Gln Met Lys His Glu Val Leu Cys Arg Trp Ile Leu Ser Val 
545                 550                 555                 560 


Lys Lys Asn Tyr Arg Lys Asn Val Ala Tyr His Asn Trp Arg His Ala 
                565                 570                 575     


Phe Asn Thr Ala Gln Cys Met Phe Ala Ala Leu Lys Ala Gly Lys Ile 
            580                 585                 590         


Gln Asn Lys Leu Thr Asp Leu Glu Ile Leu Ala Leu Leu Ile Ala Ala 
        595                 600                 605             


Leu Ser His Asp Leu Asp His Arg Gly Val Asn Asn Ser Tyr Ile Gln 
    610                 615                 620                 


Arg Ser Glu His Pro Leu Ala Gln Leu Tyr Cys His Ser Ile Met Glu 
625                 630                 635                 640 


His His His Phe Asp Gln Cys Leu Met Ile Leu Asn Ser Pro Gly Asn 
                645                 650                 655     


Gln Ile Leu Ser Gly Leu Ser Ile Glu Glu Tyr Lys Thr Thr Leu Lys 
            660                 665                 670         


Ile Ile Lys Gln Ala Ile Leu Ala Thr Asp Leu Ala Leu Tyr Ile Lys 
        675                 680                 685             


Arg Arg Gly Glu Phe Phe Glu Leu Ile Arg Lys Asn Gln Phe Asn Leu 
    690                 695                 700                 


Glu Asp Pro His Gln Lys Glu Leu Phe Leu Ala Met Leu Met Thr Ala 
705                 710                 715                 720 


Cys Asp Leu Ser Ala Ile Thr Lys Pro Trp Pro Ile Gln Gln Arg Ile 
                725                 730                 735     


Ala Glu Leu Val Ala Thr Glu Phe Phe Asp Gln Gly Asp Arg Glu Arg 
            740                 745                 750         


Lys Glu Leu Asn Ile Glu Pro Thr Asp Leu Met Asn Arg Glu Lys Lys 
        755                 760                 765             


Asn Lys Ile Pro Ser Met Gln Val Gly Phe Ile Asp Ala Ile Cys Leu 
    770                 775                 780                 


Gln Leu Tyr Glu Ala Leu Thr His Val Ser Glu Asp Cys Phe Pro Leu 
785                 790                 795                 800 


Leu Asp Gly Cys Arg Lys Asn Arg Gln Lys Trp Gln Ala Leu Ala Glu 
                805                 810                 815     


Gln Gln Glu Lys Met Leu Ile Asn Gly Glu Ser Gly Gln Ala Lys Arg 
            820                 825                 830         


Asn 
    


<210> 4
<211> 6836
<212> DNA
<213> Homo sapiens

<400> 4
tggttctgag tcgccgacct cacctcacct cacctgcgcg cgttgttgcc cctacggagc       60

ctcctggagt ccaggatcgg cggagttcga aaacgaactt cccacgtttg ctatgttgcc      120

ctttggagac aaaacaagag aaatggtcaa tgcatggttt gctgagagag ttcacaccat      180

ccctgtgtgc aaggaaggta tcagaggcca caccgaatct tgctcttgtc ccttgcagca      240

gagtcctcgt gcagataaca gtgcccctgg aacaccaacc aggaaaatct ctgcctctga      300

atttgaccgg cctcttagac ccattgttgt caaggattct gagggaactg tgagcttcct      360

ctctgactca gaaaagaagg aacagatgcc tctaacccct ccaaggtttg atcatgatga      420

aggggaccag tgctcaagac tcttggaatt agtgaaggat atttctagtc atttggatgt      480

cacagcctta tgtcacaaaa ttttcttgca tatccatgga ctgatatctg ctgaccgcta      540

ttccctgttc cttgtctgtg aagacagctc caatgacaag tttcttatca gccgcctctt      600

tgatgttgct gaaggttcaa cactggaaga agtttcaaat aactgtatcc gcttagaatg      660

gaacaaaggc attgtgggac atgtggcagc gcttggtgag cccttgaaca tcaaagatgc      720

atatgaggat cctcggttca atgcagaagt tgaccaaatt acaggctaca agacacaaag      780

cattctttgt atgccaatta agaatcatag ggaagaggtt gttggtgtag cccaggccat      840

caacaagaaa tcaggaaacg gtgggacatt tactgaaaaa gatgaaaagg actttgctgc      900

ttatttggca ttttgtggta ttgttcttca taatgctcag ctctatgaga cttcactgct      960

ggagaacaag agaaatcagg tgctgcttga ccttgctagt ttaatttttg aagaacaaca     1020

atcattagaa gtaattttga agaaaatagc tgccactatt atctctttca tgcaagtgca     1080

gaaatgcacc attttcatag tggatgaaga ttgctccgat tctttttcta gtgtgtttca     1140

catggagtgt gaggaattag aaaaatcatc tgatacatta acaagggaac atgatgcaaa     1200

caaaatcaat tacatgtatg ctcagtatgt caaaaatact atggaaccac ttaatatccc     1260

agatgtcagt aaggataaaa gatttccctg gacaactgaa aatacaggaa atgtaaacca     1320

gcagtgcatt agaagtttgc tttgtacacc tataaaaaat ggaaagaaga ataaagttat     1380

aggggtttgc caacttgtta ataagatgga ggagaatact ggcaaggtta agcctttcaa     1440

ccgaaatgac gaacagtttc tggaagcttt tgtcatcttt tgtggcttgg ggatccagaa     1500

cacgcagatg tatgaagcag tggagagagc catggccaag caaatggtca cattggaggt     1560

tctgtcgtat catgcttcag cagcagagga agaaacaaga gagctacagt cgttagcggc     1620

tgctgtggtg ccatctgccc agacccttaa aattactgac tttagcttca gtgactttga     1680

gctgtctgat ctggaaacag cactgtgtac aattcggatg tttactgacc tcaaccttgt     1740

gcagaacttc cagatgaaac atgaggttct ttgcagatgg attttaagtg ttaagaagaa     1800

ttatcggaag aatgttgcct atcataattg gagacatgcc tttaatacag ctcagtgcat     1860

gtttgctgct ctaaaagcag gcaaaattca gaacaagctg actgacctgg agatacttgc     1920

attgctgatt gctgcactaa gccacgattt ggatcaccgt ggtgtgaata actcttacat     1980

acagcgaagt gaacatccac ttgcccagct ttactgccat tcaatcatgg aacaccatca     2040

ttttgaccag tgcctgatga ttcttaatag tccaggcaat cagattctca gtggcctctc     2100

cattgaagaa tataagacca cgttgaaaat aatcaagcaa gctattttag ctacagacct     2160

agcactgtac attaagaggc gaggagaatt ttttgaactt ataagaaaaa atcaattcaa     2220

tttggaagat cctcatcaaa aggagttgtt tttggcaatg ctgatgacag cttgtgatct     2280

ttctgcaatt acaaaaccct ggcctattca acaacggata gcagaacttg tagcaactga     2340

attttttgat caaggagaca gagagagaaa agaactcaac atagaaccca ctgatctaat     2400

gaacagggag aagaaaaaca aaatcccaag tatgcaagtt gggttcatag atgccatctg     2460

cttgcaactg tatgaggccc tgacccacgt gtcagaggac tgtttccctt tgctagatgg     2520

ctgcagaaag aacaggcaga aatggcaggc ccttgcagaa cagcaggaga agatgctgat     2580

taatggggaa agcggccagg ccaagcggaa ctgagtggcc tatttcatgc agagttgaag     2640

tttacagaga tggtgtgttc tgcaatatgc ctagtttctt acacactgtc tgtatagtgt     2700

ctgtatttgg tatatacttt gccactgctg tatttttatt tttgcacaac ttttgagagt     2760

atagcatgaa tgtttttaga ggactattac atattttttg tatatttgtt ttatgctact     2820

gaactgaaag gatcaacaac atccactgtt agcacattga taaaagcatt gtttgtgata     2880

tttcgtgtac tgcaaagtgt atgcagtatt cttgcactga ggtttttttg cttggggatt     2940

attttaaata attggttttt gtgttttctg aattaccatt ttttcaagaa tgtttggaat     3000

ctttcctttt tcaaaagtag gttaggagca aattatcata cattctgtga catttaaagc     3060

ctttatagga tagtgaaaaa tgctggctga gtggatttta agagaaataa ttgtatttgt     3120

taacagtgtc tttttttaaa aagttaaggc actctgaaac aaatggaaag tcctatgaaa     3180

ctgtattgta aagaaaacat tatttaattg atatgctgtt ttgtgagaga acaggcaaga     3240

cagaactttg tcacttcagt gcagtacatt tttctgaaag ctacccataa aatcactttc     3300

atctcaccta cctgatgcaa agcaggtgaa accttaggag atgatccagt cactgacttg     3360

attgagggat aagtgtgatt tagaaatgga atggccttgg atgtctatca gtgaagaaaa     3420

atgttctgtt agaagatctc tctaagagtt tttttccttc tgagcttcct tttcaaaata     3480

aaagtgacaa ttgtagcatt gacttgaagt gagacatggt tatagataag agagtacaaa     3540

atgactcttt ttcctgtcaa ttgaaattta aagaaaagtt ttaattatat aaatagcaaa     3600

gggctattgc caatactagg gtcaaaaatg aatttgaggg aacagtgggt aagaaacttt     3660

atgcctgaat aacatttagc agtattgtga ttgaaaaatt gccatatttt gatgtatagg     3720

acaagtcaac tgagatccag agaatcctgg atgtgaatgc taaacactgg cccttaactc     3780

acattcaatg tattttcttc ccataacatt tagtatagtt aatattttct tagaatttga     3840

gcccatttaa gtggattaat attctacatg tgtgccccta aagacacatt tactcaatat     3900

tggagaagta gataatgaat taagcaactg gtctaggaaa ggaaaatttg tttcaaatat     3960

gcaggaatgt ttggatttgg ggagagtaga aggagagatt tgcttgattt gttaacttct     4020

acctccaacc cacaaaaaag atatttgatc tgagtttcta tcactaattt ggatagaaaa     4080

tttctaaggg acatggtaat ccagcattct caaggacctt tcgccaaaat gtgttttcca     4140

tctatgtccc gattccccta aattttgcct aaaattcagt atgttcctta agtttttaaa     4200

attctgagtg tgtacaaata tcttgacata atgcagtttt atttttatca ttctggtaaa     4260

aaaacaaaaa atagaagcaa aacacattgt attgccatta ttttgtattt ggtaaaggtt     4320

aatctaggaa gttaccaact gtttaatgct atatgtattg tatacttgta ttttcaggat     4380

attttatttt ttttgccata cagataaaat ttgtaaggtt gcccctttgt ggcactggtg     4440

tgtaaaatac acagactatc actaaaataa tagttatata tacatacagg tgtatactta     4500

tgcatgcata cataaatcct tagtatagaa aaattgcata aagaatagca atctttaata     4560

aaccttttta ttacattgtg atttagcagt tatgctaaaa tatgtactta tgctttagta     4620

gtttgtttgg tcccctctag tatgtgtcac tgagaaattt tttaaagaca tggtagatcg     4680

tgtttagagg ctttgtatgt gtgtcatttt aataagcaag aagatatatt tagattagaa     4740

atggtttggt ctgcctttga atattgttta ttttacttta ctagttgaga cattaaagga     4800

agctgggcaa tgcctatttt atttctttgt tggatatttt agttcataca aagcagagta     4860

cttctttagg gctggttaat tggttcaaat aatttttaat ttcctttcta gtatcttctc     4920

aagttggaaa aatatacata cagtcctcct tcaccttact ctgtatttat attacccata     4980

actagcaaga agttcttgtt ctagattttt tgtttgttta gttataacag agtaacatac     5040

catttaatta caatttttag ccagaaaagt ccccactatt ttactaactt gttaaaagat     5100

atctatataa ttgcctggcc ttatattttt cagtagatta gaccgtgcca atcacaatcc     5160

tgggtggatt tgtgtaagtc acttaacctc tgtgtgccta aacaagttgt gcttttttaa     5220

aaggagttat gtttgggcaa agcctttgtc ttcaagcaga atgtcacaga aggcagctac     5280

tttataagcc ccaatgggcc atggagacca ctgtcagaaa tgggatatta gtctagagag     5340

aaggtgatct attcccacat gtcatttcta atgttgagtt tccatgactg aacaaagaga     5400

atatatttat tcagcttcac ttgcagatca ctagtgaatg tgagatttag agctcattga     5460

gtatattgct tcaaggtaca aacccaggat gatgatgttg tcaccactgt ctcttaattt     5520

tgaataatag tttcctttaa taggagtatt agagataaga aagtatatga aaatatactg     5580

gaaatattgg attcttggag aaaactgttc agtcacagat atattcttgc ctagcagtga     5640

agtgccttta ttttcagcat agcaaataaa tattagacct gttccaattt gatctacaat     5700

ttttttctgt gtttttcacc agattgtact cctaaaactt aacaggccat cacaagcaat     5760

tgtcttttgt ttacaagatt gatttaatat gagaggatac aaaatgtcat cgttatcctc     5820

tcttatgaac aactgtagtc aaaataaggt ggcacaattt aattgttttg tatcagaaat     5880

acactgaccc accttttatt gagtcctgcc acatgttagg taccgtgctc tgctgtggag     5940

acagagcagt gaccccaagg agctcacggt ccctgaagga ggtgctagag aagagactta     6000

gcttctgata ctgccaattt aatgtgagaa catggggtat actgcatcat ttccattttc     6060

atcaataaca tatgttttat gcaccttctt tacctgaaac ttactaagaa tctaccagta     6120

aacaaacatc ctgtcttttt gcaagtatga atcacttaac ctgctgatag ttgaagaaca     6180

ctttaggagt tttgtattct tgtatatagt ttattttttc catgtgctag ccaggtaaag     6240

attacacagt tcttctggac tgttaaattg tgcatggttt tggacccctt ctgctctact     6300

acagagagtg aagaagaaag tattaaagct cactttacca ttccatatac ttactaaaag     6360

cctgtgtaaa catgtcttaa tgaatgttgt tgaaagcaat gtaaatagtt gaaaatataa     6420

atttatatta cagtttaaga aaaccttatg aggcatcact agccactgtt aatatctatt     6480

tgtattctta taccttttca atatatttga acaaatatag tttctggcac tatttttata     6540

ctaggaaaag gagttactat gtatattatg cttagctttt aaggcatttt aaataaccat     6600

gaatgttgat ttcattactt tcctttcctc catcacgaga gtcatttcag atgactcttt     6660

catgacaaaa tcactttaaa ggaacactta cctccgattc ctgtataaag tcatgagatg     6720

gtcaaggtgg ttttccattg tgcaaattct tcacctgtca gtggtttcct cattttgcca     6780

tgctttgtaa aaataaaaag aatgatcaag taggtatgaa aaaaaaaaaa aaaaaa         6836


<210> 5
<211> 823
<212> PRT
<213> Homo sapiens

<400> 5
Met Val Asn Ala Trp Phe Ala Glu Arg Val His Thr Ile Pro Val Cys 
1               5                   10                  15      


Lys Glu Gly Ile Arg Gly His Thr Glu Ser Cys Ser Cys Pro Leu Gln 
            20                  25                  30          


Gln Ser Pro Arg Ala Asp Asn Ser Ala Pro Gly Thr Pro Thr Arg Lys 
        35                  40                  45              


Ile Ser Ala Ser Glu Phe Asp Arg Pro Leu Arg Pro Ile Val Val Lys 
    50                  55                  60                  


Asp Ser Glu Gly Thr Val Ser Phe Leu Ser Asp Ser Glu Lys Lys Glu 
65                  70                  75                  80  


Gln Met Pro Leu Thr Pro Pro Arg Phe Asp His Asp Glu Gly Asp Gln 
                85                  90                  95      


Cys Ser Arg Leu Leu Glu Leu Val Lys Asp Ile Ser Ser His Leu Asp 
            100                 105                 110         


Val Thr Ala Leu Cys His Lys Ile Phe Leu His Ile His Gly Leu Ile 
        115                 120                 125             


Ser Ala Asp Arg Tyr Ser Leu Phe Leu Val Cys Glu Asp Ser Ser Asn 
    130                 135                 140                 


Asp Lys Phe Leu Ile Ser Arg Leu Phe Asp Val Ala Glu Gly Ser Thr 
145                 150                 155                 160 


Leu Glu Glu Val Ser Asn Asn Cys Ile Arg Leu Glu Trp Asn Lys Gly 
                165                 170                 175     


Ile Val Gly His Val Ala Ala Leu Gly Glu Pro Leu Asn Ile Lys Asp 
            180                 185                 190         


Ala Tyr Glu Asp Pro Arg Phe Asn Ala Glu Val Asp Gln Ile Thr Gly 
        195                 200                 205             


Tyr Lys Thr Gln Ser Ile Leu Cys Met Pro Ile Lys Asn His Arg Glu 
    210                 215                 220                 


Glu Val Val Gly Val Ala Gln Ala Ile Asn Lys Lys Ser Gly Asn Gly 
225                 230                 235                 240 


Gly Thr Phe Thr Glu Lys Asp Glu Lys Asp Phe Ala Ala Tyr Leu Ala 
                245                 250                 255     


Phe Cys Gly Ile Val Leu His Asn Ala Gln Leu Tyr Glu Thr Ser Leu 
            260                 265                 270         


Leu Glu Asn Lys Arg Asn Gln Val Leu Leu Asp Leu Ala Ser Leu Ile 
        275                 280                 285             


Phe Glu Glu Gln Gln Ser Leu Glu Val Ile Leu Lys Lys Ile Ala Ala 
    290                 295                 300                 


Thr Ile Ile Ser Phe Met Gln Val Gln Lys Cys Thr Ile Phe Ile Val 
305                 310                 315                 320 


Asp Glu Asp Cys Ser Asp Ser Phe Ser Ser Val Phe His Met Glu Cys 
                325                 330                 335     


Glu Glu Leu Glu Lys Ser Ser Asp Thr Leu Thr Arg Glu His Asp Ala 
            340                 345                 350         


Asn Lys Ile Asn Tyr Met Tyr Ala Gln Tyr Val Lys Asn Thr Met Glu 
        355                 360                 365             


Pro Leu Asn Ile Pro Asp Val Ser Lys Asp Lys Arg Phe Pro Trp Thr 
    370                 375                 380                 


Thr Glu Asn Thr Gly Asn Val Asn Gln Gln Cys Ile Arg Ser Leu Leu 
385                 390                 395                 400 


Cys Thr Pro Ile Lys Asn Gly Lys Lys Asn Lys Val Ile Gly Val Cys 
                405                 410                 415     


Gln Leu Val Asn Lys Met Glu Glu Asn Thr Gly Lys Val Lys Pro Phe 
            420                 425                 430         


Asn Arg Asn Asp Glu Gln Phe Leu Glu Ala Phe Val Ile Phe Cys Gly 
        435                 440                 445             


Leu Gly Ile Gln Asn Thr Gln Met Tyr Glu Ala Val Glu Arg Ala Met 
    450                 455                 460                 


Ala Lys Gln Met Val Thr Leu Glu Val Leu Ser Tyr His Ala Ser Ala 
465                 470                 475                 480 


Ala Glu Glu Glu Thr Arg Glu Leu Gln Ser Leu Ala Ala Ala Val Val 
                485                 490                 495     


Pro Ser Ala Gln Thr Leu Lys Ile Thr Asp Phe Ser Phe Ser Asp Phe 
            500                 505                 510         


Glu Leu Ser Asp Leu Glu Thr Ala Leu Cys Thr Ile Arg Met Phe Thr 
        515                 520                 525             


Asp Leu Asn Leu Val Gln Asn Phe Gln Met Lys His Glu Val Leu Cys 
    530                 535                 540                 


Arg Trp Ile Leu Ser Val Lys Lys Asn Tyr Arg Lys Asn Val Ala Tyr 
545                 550                 555                 560 


His Asn Trp Arg His Ala Phe Asn Thr Ala Gln Cys Met Phe Ala Ala 
                565                 570                 575     


Leu Lys Ala Gly Lys Ile Gln Asn Lys Leu Thr Asp Leu Glu Ile Leu 
            580                 585                 590         


Ala Leu Leu Ile Ala Ala Leu Ser His Asp Leu Asp His Arg Gly Val 
        595                 600                 605             


Asn Asn Ser Tyr Ile Gln Arg Ser Glu His Pro Leu Ala Gln Leu Tyr 
    610                 615                 620                 


Cys His Ser Ile Met Glu His His His Phe Asp Gln Cys Leu Met Ile 
625                 630                 635                 640 


Leu Asn Ser Pro Gly Asn Gln Ile Leu Ser Gly Leu Ser Ile Glu Glu 
                645                 650                 655     


Tyr Lys Thr Thr Leu Lys Ile Ile Lys Gln Ala Ile Leu Ala Thr Asp 
            660                 665                 670         


Leu Ala Leu Tyr Ile Lys Arg Arg Gly Glu Phe Phe Glu Leu Ile Arg 
        675                 680                 685             


Lys Asn Gln Phe Asn Leu Glu Asp Pro His Gln Lys Glu Leu Phe Leu 
    690                 695                 700                 


Ala Met Leu Met Thr Ala Cys Asp Leu Ser Ala Ile Thr Lys Pro Trp 
705                 710                 715                 720 


Pro Ile Gln Gln Arg Ile Ala Glu Leu Val Ala Thr Glu Phe Phe Asp 
                725                 730                 735     


Gln Gly Asp Arg Glu Arg Lys Glu Leu Asn Ile Glu Pro Thr Asp Leu 
            740                 745                 750         


Met Asn Arg Glu Lys Lys Asn Lys Ile Pro Ser Met Gln Val Gly Phe 
        755                 760                 765             


Ile Asp Ala Ile Cys Leu Gln Leu Tyr Glu Ala Leu Thr His Val Ser 
    770                 775                 780                 


Glu Asp Cys Phe Pro Leu Leu Asp Gly Cys Arg Lys Asn Arg Gln Lys 
785                 790                 795                 800 


Trp Gln Ala Leu Ala Glu Gln Gln Glu Lys Met Leu Ile Asn Gly Glu 
                805                 810                 815     


Ser Gly Gln Ala Lys Arg Asn 
            820             


<210> 6
<211> 6788
<212> DNA
<213> Homo sapiens

<400> 6
cctcgccctg gccctggctg ggcggggaag ctggggtgag ggacgagtcc acgggacagc       60

ccaaaggcaa catgacggaa ccttgccaaa agaaatggtc aatgcatggt ttgctgagag      120

agttcacacc atccctgtgt gcaaggaagg tatcagaggc cacaccgaat cttgctcttg      180

tcccttgcag cagagtcctc gtgcagataa cagtgcccct ggaacaccaa ccaggaaaat      240

ctctgcctct gaatttgacc ggcctcttag acccattgtt gtcaaggatt ctgagggaac      300

tgtgagcttc ctctctgact cagaaaagaa ggaacagatg cctctaaccc ctccaaggtt      360

tgatcatgat gaaggggacc agtgctcaag actcttggaa ttagtgaagg atatttctag      420

tcatttggat gtcacagcct tatgtcacaa aattttcttg catatccatg gactgatatc      480

tgctgaccgc tattccctgt tccttgtctg tgaagacagc tccaatgaca agtttcttat      540

cagccgcctc tttgatgttg ctgaaggttc aacactggaa gaagtttcaa ataactgtat      600

ccgcttagaa tggaacaaag gcattgtggg acatgtggca gcgcttggtg agcccttgaa      660

catcaaagat gcatatgagg atcctcggtt caatgcagaa gttgaccaaa ttacaggcta      720

caagacacaa agcattcttt gtatgccaat taagaatcat agggaagagg ttgttggtgt      780

agcccaggcc atcaacaaga aatcaggaaa cggtgggaca tttactgaaa aagatgaaaa      840

ggactttgct gcttatttgg cattttgtgg tattgttctt cataatgctc agctctatga      900

gacttcactg ctggagaaca agagaaatca ggtgctgctt gaccttgcta gtttaatttt      960

tgaagaacaa caatcattag aagtaatttt gaagaaaata gctgccacta ttatctcttt     1020

catgcaagtg cagaaatgca ccattttcat agtggatgaa gattgctccg attctttttc     1080

tagtgtgttt cacatggagt gtgaggaatt agaaaaatca tctgatacat taacaaggga     1140

acatgatgca aacaaaatca attacatgta tgctcagtat gtcaaaaata ctatggaacc     1200

acttaatatc ccagatgtca gtaaggataa aagatttccc tggacaactg aaaatacagg     1260

aaatgtaaac cagcagtgca ttagaagttt gctttgtaca cctataaaaa atggaaagaa     1320

gaataaagtt ataggggttt gccaacttgt taataagatg gaggagaata ctggcaaggt     1380

taagcctttc aaccgaaatg acgaacagtt tctggaagct tttgtcatct tttgtggctt     1440

ggggatccag aacacgcaga tgtatgaagc agtggagaga gccatggcca agcaaatggt     1500

cacattggag gttctgtcgt atcatgcttc agcagcagag gaagaaacaa gagagctaca     1560

gtcgttagcg gctgctgtgg tgccatctgc ccagaccctt aaaattactg actttagctt     1620

cagtgacttt gagctgtctg atctggaaac agcactgtgt acaattcgga tgtttactga     1680

cctcaacctt gtgcagaact tccagatgaa acatgaggtt ctttgcagat ggattttaag     1740

tgttaagaag aattatcgga agaatgttgc ctatcataat tggagacatg cctttaatac     1800

agctcagtgc atgtttgctg ctctaaaagc aggcaaaatt cagaacaagc tgactgacct     1860

ggagatactt gcattgctga ttgctgcact aagccacgat ttggatcacc gtggtgtgaa     1920

taactcttac atacagcgaa gtgaacatcc acttgcccag ctttactgcc attcaatcat     1980

ggaacaccat cattttgacc agtgcctgat gattcttaat agtccaggca atcagattct     2040

cagtggcctc tccattgaag aatataagac cacgttgaaa ataatcaagc aagctatttt     2100

agctacagac ctagcactgt acattaagag gcgaggagaa ttttttgaac ttataagaaa     2160

aaatcaattc aatttggaag atcctcatca aaaggagttg tttttggcaa tgctgatgac     2220

agcttgtgat ctttctgcaa ttacaaaacc ctggcctatt caacaacgga tagcagaact     2280

tgtagcaact gaattttttg atcaaggaga cagagagaga aaagaactca acatagaacc     2340

cactgatcta atgaacaggg agaagaaaaa caaaatccca agtatgcaag ttgggttcat     2400

agatgccatc tgcttgcaac tgtatgaggc cctgacccac gtgtcagagg actgtttccc     2460

tttgctagat ggctgcagaa agaacaggca gaaatggcag gcccttgcag aacagcagga     2520

gaagatgctg attaatgggg aaagcggcca ggccaagcgg aactgagtgg cctatttcat     2580

gcagagttga agtttacaga gatggtgtgt tctgcaatat gcctagtttc ttacacactg     2640

tctgtatagt gtctgtattt ggtatatact ttgccactgc tgtattttta tttttgcaca     2700

acttttgaga gtatagcatg aatgttttta gaggactatt acatattttt tgtatatttg     2760

ttttatgcta ctgaactgaa aggatcaaca acatccactg ttagcacatt gataaaagca     2820

ttgtttgtga tatttcgtgt actgcaaagt gtatgcagta ttcttgcact gaggtttttt     2880

tgcttgggga ttattttaaa taattggttt ttgtgttttc tgaattacca ttttttcaag     2940

aatgtttgga atctttcctt tttcaaaagt aggttaggag caaattatca tacattctgt     3000

gacatttaaa gcctttatag gatagtgaaa aatgctggct gagtggattt taagagaaat     3060

aattgtattt gttaacagtg tcttttttta aaaagttaag gcactctgaa acaaatggaa     3120

agtcctatga aactgtattg taaagaaaac attatttaat tgatatgctg ttttgtgaga     3180

gaacaggcaa gacagaactt tgtcacttca gtgcagtaca tttttctgaa agctacccat     3240

aaaatcactt tcatctcacc tacctgatgc aaagcaggtg aaaccttagg agatgatcca     3300

gtcactgact tgattgaggg ataagtgtga tttagaaatg gaatggcctt ggatgtctat     3360

cagtgaagaa aaatgttctg ttagaagatc tctctaagag tttttttcct tctgagcttc     3420

cttttcaaaa taaaagtgac aattgtagca ttgacttgaa gtgagacatg gttatagata     3480

agagagtaca aaatgactct ttttcctgtc aattgaaatt taaagaaaag ttttaattat     3540

ataaatagca aagggctatt gccaatacta gggtcaaaaa tgaatttgag ggaacagtgg     3600

gtaagaaact ttatgcctga ataacattta gcagtattgt gattgaaaaa ttgccatatt     3660

ttgatgtata ggacaagtca actgagatcc agagaatcct ggatgtgaat gctaaacact     3720

ggcccttaac tcacattcaa tgtattttct tcccataaca tttagtatag ttaatatttt     3780

cttagaattt gagcccattt aagtggatta atattctaca tgtgtgcccc taaagacaca     3840

tttactcaat attggagaag tagataatga attaagcaac tggtctagga aaggaaaatt     3900

tgtttcaaat atgcaggaat gtttggattt ggggagagta gaaggagaga tttgcttgat     3960

ttgttaactt ctacctccaa cccacaaaaa agatatttga tctgagtttc tatcactaat     4020

ttggatagaa aatttctaag ggacatggta atccagcatt ctcaaggacc tttcgccaaa     4080

atgtgttttc catctatgtc ccgattcccc taaattttgc ctaaaattca gtatgttcct     4140

taagttttta aaattctgag tgtgtacaaa tatcttgaca taatgcagtt ttatttttat     4200

cattctggta aaaaaacaaa aaatagaagc aaaacacatt gtattgccat tattttgtat     4260

ttggtaaagg ttaatctagg aagttaccaa ctgtttaatg ctatatgtat tgtatacttg     4320

tattttcagg atattttatt ttttttgcca tacagataaa atttgtaagg ttgccccttt     4380

gtggcactgg tgtgtaaaat acacagacta tcactaaaat aatagttata tatacataca     4440

ggtgtatact tatgcatgca tacataaatc cttagtatag aaaaattgca taaagaatag     4500

caatctttaa taaacctttt tattacattg tgatttagca gttatgctaa aatatgtact     4560

tatgctttag tagtttgttt ggtcccctct agtatgtgtc actgagaaat tttttaaaga     4620

catggtagat cgtgtttaga ggctttgtat gtgtgtcatt ttaataagca agaagatata     4680

tttagattag aaatggtttg gtctgccttt gaatattgtt tattttactt tactagttga     4740

gacattaaag gaagctgggc aatgcctatt ttatttcttt gttggatatt ttagttcata     4800

caaagcagag tacttcttta gggctggtta attggttcaa ataattttta atttcctttc     4860

tagtatcttc tcaagttgga aaaatataca tacagtcctc cttcacctta ctctgtattt     4920

atattaccca taactagcaa gaagttcttg ttctagattt tttgtttgtt tagttataac     4980

agagtaacat accatttaat tacaattttt agccagaaaa gtccccacta ttttactaac     5040

ttgttaaaag atatctatat aattgcctgg ccttatattt ttcagtagat tagaccgtgc     5100

caatcacaat cctgggtgga tttgtgtaag tcacttaacc tctgtgtgcc taaacaagtt     5160

gtgctttttt aaaaggagtt atgtttgggc aaagcctttg tcttcaagca gaatgtcaca     5220

gaaggcagct actttataag ccccaatggg ccatggagac cactgtcaga aatgggatat     5280

tagtctagag agaaggtgat ctattcccac atgtcatttc taatgttgag tttccatgac     5340

tgaacaaaga gaatatattt attcagcttc acttgcagat cactagtgaa tgtgagattt     5400

agagctcatt gagtatattg cttcaaggta caaacccagg atgatgatgt tgtcaccact     5460

gtctcttaat tttgaataat agtttccttt aataggagta ttagagataa gaaagtatat     5520

gaaaatatac tggaaatatt ggattcttgg agaaaactgt tcagtcacag atatattctt     5580

gcctagcagt gaagtgcctt tattttcagc atagcaaata aatattagac ctgttccaat     5640

ttgatctaca atttttttct gtgtttttca ccagattgta ctcctaaaac ttaacaggcc     5700

atcacaagca attgtctttt gtttacaaga ttgatttaat atgagaggat acaaaatgtc     5760

atcgttatcc tctcttatga acaactgtag tcaaaataag gtggcacaat ttaattgttt     5820

tgtatcagaa atacactgac ccacctttta ttgagtcctg ccacatgtta ggtaccgtgc     5880

tctgctgtgg agacagagca gtgaccccaa ggagctcacg gtccctgaag gaggtgctag     5940

agaagagact tagcttctga tactgccaat ttaatgtgag aacatggggt atactgcatc     6000

atttccattt tcatcaataa catatgtttt atgcaccttc tttacctgaa acttactaag     6060

aatctaccag taaacaaaca tcctgtcttt ttgcaagtat gaatcactta acctgctgat     6120

agttgaagaa cactttagga gttttgtatt cttgtatata gtttattttt tccatgtgct     6180

agccaggtaa agattacaca gttcttctgg actgttaaat tgtgcatggt tttggacccc     6240

ttctgctcta ctacagagag tgaagaagaa agtattaaag ctcactttac cattccatat     6300

acttactaaa agcctgtgta aacatgtctt aatgaatgtt gttgaaagca atgtaaatag     6360

ttgaaaatat aaatttatat tacagtttaa gaaaacctta tgaggcatca ctagccactg     6420

ttaatatcta tttgtattct tatacctttt caatatattt gaacaaatat agtttctggc     6480

actattttta tactaggaaa aggagttact atgtatatta tgcttagctt ttaaggcatt     6540

ttaaataacc atgaatgttg atttcattac tttcctttcc tccatcacga gagtcatttc     6600

agatgactct ttcatgacaa aatcacttta aaggaacact tacctccgat tcctgtataa     6660

agtcatgaga tggtcaaggt ggttttccat tgtgcaaatt cttcacctgt cagtggtttc     6720

ctcattttgc catgctttgt aaaaataaaa agaatgatca agtaggtatg aaaaaaaaaa     6780

aaaaaaaa                                                              6788


<210> 7
<211> 326
<212> PRT
<213> Homo sapiens

<400> 7
Glu Glu Thr Arg Glu Leu Gln Ser Leu Ala Ala Ala Val Val Pro Ser 
1               5                   10                  15      


Ala Gln Thr Leu Lys Ile Thr Asp Phe Ser Phe Ser Asp Phe Glu Leu 
            20                  25                  30          


Ser Asp Leu Glu Thr Ala Leu Cys Thr Ile Arg Met Phe Thr Asp Leu 
        35                  40                  45              


Asn Leu Val Gln Asn Phe Gln Met Lys His Glu Val Leu Cys Arg Trp 
    50                  55                  60                  


Ile Leu Ser Val Lys Lys Asn Tyr Arg Lys Asn Val Ala Tyr His Asn 
65                  70                  75                  80  


Trp Arg His Ala Phe Asn Thr Ala Gln Cys Met Phe Ala Ala Leu Lys 
                85                  90                  95      


Ala Gly Lys Ile Gln Asn Lys Leu Thr Asp Leu Glu Ile Leu Ala Leu 
            100                 105                 110         


Leu Ile Ala Ala Leu Ser His Asp Leu Asp His Arg Gly Val Asn Asn 
        115                 120                 125             


Ser Tyr Ile Gln Arg Ser Glu His Pro Leu Ala Gln Leu Tyr Cys His 
    130                 135                 140                 


Ser Ile Met Glu His His His Phe Asp Gln Cys Leu Met Ile Leu Asn 
145                 150                 155                 160 


Ser Pro Gly Asn Gln Ile Leu Ser Gly Leu Ser Ile Glu Glu Tyr Lys 
                165                 170                 175     


Thr Thr Leu Lys Ile Ile Lys Gln Ala Ile Leu Ala Thr Asp Leu Ala 
            180                 185                 190         


Leu Tyr Ile Lys Arg Arg Gly Glu Phe Phe Glu Leu Ile Arg Lys Asn 
        195                 200                 205             


Gln Phe Asn Leu Glu Asp Pro His Gln Lys Glu Leu Phe Leu Ala Met 
    210                 215                 220                 


Leu Met Thr Ala Cys Asp Leu Ser Ala Ile Thr Lys Pro Trp Pro Ile 
225                 230                 235                 240 


Gln Gln Arg Ile Ala Glu Leu Val Ala Thr Glu Phe Phe Asp Gln Gly 
                245                 250                 255     


Asp Arg Glu Arg Lys Glu Leu Asn Ile Glu Pro Thr Asp Leu Met Asn 
            260                 265                 270         


Arg Glu Lys Lys Asn Lys Ile Pro Ser Met Gln Val Gly Phe Ile Asp 
        275                 280                 285             


Ala Ile Cys Leu Gln Leu Tyr Glu Ala Leu Thr His Val Ser Glu Asp 
    290                 295                 300                 


Cys Phe Pro Leu Leu Asp Gly Cys Arg Lys Asn Arg Gln Lys Trp Gln 
305                 310                 315                 320 


Ala Leu Ala Glu Gln Gln 
                325     


<210> 8
<211> 978
<212> DNA
<213> Homo sapiens

<400> 8
gaagaaacaa gagagctaca gtcgttagcg gctgctgtgg tgccatctgc ccagaccctt       60

aaaattactg actttagctt cagtgacttt gagctgtctg atctggaaac agcactgtgt      120

acaattcgga tgtttactga cctcaacctt gtgcagaact tccagatgaa acatgaggtt      180

ctttgcagat ggattttaag tgttaagaag aattatcgga agaatgttgc ctatcataat      240

tggagacatg cctttaatac agctcagtgc atgtttgctg ctctaaaagc aggcaaaatt      300

cagaacaagc tgactgacct ggagatactt gcattgctga ttgctgcact aagccacgat      360

ttggatcacc gtggtgtgaa taactcttac atacagcgaa gtgaacatcc acttgcccag      420

ctttactgcc attcaatcat ggaacaccat cattttgacc agtgcctgat gattcttaat      480

agtccaggca atcagattct cagtggcctc tccattgaag aatataagac cacgttgaaa      540

ataatcaagc aagctatttt agctacagac ctagcactgt acattaagag gcgaggagaa      600

ttttttgaac ttataagaaa aaatcaattc aatttggaag atcctcatca aaaggagttg      660

tttttggcaa tgctgatgac agcttgtgat ctttctgcaa ttacaaaacc ctggcctatt      720

caacaacgga tagcagaact tgtagcaact gaattttttg atcaaggaga cagagagaga      780

aaagaactca acatagaacc cactgatcta atgaacaggg agaagaaaaa caaaatccca      840

agtatgcaag ttgggttcat agatgccatc tgcttgcaac tgtatgaggc cctgacccac      900

gtgtcagagg actgtttccc tttgctagat ggctgcagaa agaacaggca gaaatggcag      960

gcccttgcag aacagcag                                                    978


<210> 9
<211> 875
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      construct"

<400> 9
Met Glu Arg Ala Gly Pro Ser Phe Gly Gln Gln Arg Gln Gln Gln Gln 
1               5                   10                  15      


Pro Gln Gln Gln Lys Gln Gln Gln Arg Asp Gln Asp Ser Val Glu Ala 
            20                  25                  30          


Trp Leu Asp Gly His Trp Asp Phe Thr Phe Ser Tyr Phe Val Arg Lys 
        35                  40                  45              


Ala Thr Arg Glu Met Val Asn Ala Trp Phe Ala Glu Arg Val His Thr 
    50                  55                  60                  


Ile Pro Val Cys Lys Glu Gly Ile Arg Gly His Thr Glu Ser Cys Ser 
65                  70                  75                  80  


Cys Pro Leu Gln Gln Ser Pro Arg Ala Asp Asn Ser Val Pro Gly Thr 
                85                  90                  95      


Pro Thr Arg Lys Ile Ser Ala Ser Glu Phe Asp Arg Pro Leu Arg Pro 
            100                 105                 110         


Ile Val Val Lys Asp Ser Glu Gly Thr Val Ser Phe Leu Ser Asp Ser 
        115                 120                 125             


Glu Lys Lys Glu Gln Met Pro Leu Thr Pro Pro Arg Phe Asp His Asp 
    130                 135                 140                 


Glu Gly Asp Gln Cys Ser Arg Leu Leu Glu Leu Val Lys Asp Ile Ser 
145                 150                 155                 160 


Ser His Leu Asp Val Thr Ala Leu Cys His Lys Ile Phe Leu His Ile 
                165                 170                 175     


His Gly Leu Ile Ser Ala Asp Arg Tyr Ser Leu Phe Leu Val Cys Glu 
            180                 185                 190         


Asp Ser Ser Asn Asp Lys Phe Leu Ile Ser Arg Leu Phe Asp Val Ala 
        195                 200                 205             


Glu Gly Ser Thr Leu Glu Glu Val Ser Asn Asn Cys Ile Arg Leu Glu 
    210                 215                 220                 


Trp Asn Lys Gly Ile Val Gly His Val Ala Ala Leu Gly Glu Pro Leu 
225                 230                 235                 240 


Asn Ile Lys Asp Ala Tyr Glu Asp Pro Arg Phe Asn Ala Glu Val Asp 
                245                 250                 255     


Gln Ile Thr Gly Tyr Lys Thr Gln Ser Ile Leu Cys Met Pro Ile Lys 
            260                 265                 270         


Asn His Arg Glu Glu Val Val Gly Val Ala Gln Ala Ile Asn Lys Lys 
        275                 280                 285             


Ser Gly Asn Gly Gly Thr Phe Thr Glu Lys Asp Glu Lys Asp Phe Ala 
    290                 295                 300                 


Ala Tyr Leu Ala Phe Cys Gly Ile Val Leu His Asn Ala Gln Leu Tyr 
305                 310                 315                 320 


Glu Thr Ser Leu Leu Glu Asn Lys Arg Asn Gln Val Leu Leu Asp Leu 
                325                 330                 335     


Ala Ser Leu Ile Phe Glu Glu Gln Gln Ser Leu Glu Val Ile Leu Lys 
            340                 345                 350         


Lys Ile Ala Ala Thr Ile Ile Ser Phe Met Gln Val Gln Lys Cys Thr 
        355                 360                 365             


Ile Phe Ile Val Asp Glu Asp Cys Ser Asp Ser Phe Ser Ser Val Phe 
    370                 375                 380                 


His Met Glu Cys Glu Glu Leu Glu Lys Ser Ser Asp Thr Leu Thr Arg 
385                 390                 395                 400 


Glu His Asp Ala Asn Lys Ile Asn Tyr Met Tyr Ala Gln Tyr Val Lys 
                405                 410                 415     


Asn Thr Met Glu Pro Leu Asn Ile Pro Asp Val Ser Lys Asp Lys Arg 
            420                 425                 430         


Phe Pro Trp Thr Thr Glu Asn Thr Gly Asn Val Asn Gln Gln Cys Ile 
        435                 440                 445             


Arg Ser Leu Leu Cys Thr Pro Ile Lys Asn Gly Lys Lys Asn Lys Val 
    450                 455                 460                 


Ile Gly Val Cys Gln Leu Val Asn Lys Met Glu Glu Asn Thr Gly Lys 
465                 470                 475                 480 


Val Lys Pro Phe Asn Arg Asn Asp Glu Gln Phe Leu Glu Ala Phe Val 
                485                 490                 495     


Ile Phe Cys Gly Leu Gly Ile Gln Asn Thr Gln Met Tyr Glu Ala Val 
            500                 505                 510         


Glu Arg Ala Met Ala Lys Gln Met Val Thr Leu Glu Val Leu Ser Tyr 
        515                 520                 525             


His Ala Ser Ala Ala Glu Glu Glu Thr Arg Glu Leu Gln Ser Leu Ala 
    530                 535                 540                 


Ala Ala Val Val Pro Ser Ala Gln Thr Leu Lys Ile Thr Asp Phe Ser 
545                 550                 555                 560 


Phe Ser Asp Phe Glu Leu Ser Asp Leu Glu Thr Ala Leu Cys Thr Ile 
                565                 570                 575     


Arg Met Phe Thr Asp Leu Asn Leu Val Gln Asn Phe Arg Met Lys His 
            580                 585                 590         


Glu Val Leu Cys Arg Trp Ile Leu Ser Val Lys Lys Asn Tyr Arg Lys 
        595                 600                 605             


Asn Val Ala Tyr His Asn Trp Arg His Ala Phe Asn Thr Ala Gln Cys 
    610                 615                 620                 


Met Phe Ala Ala Leu Lys Ala Gly Lys Ile Gln Asn Lys Leu Thr Asp 
625                 630                 635                 640 


Leu Glu Ile Leu Ala Leu Leu Ile Ala Ala Leu Ser His Asp Leu Asp 
                645                 650                 655     


His Arg Gly Val Asn Asn Ser Tyr Ile Gln Arg Ser Glu His Pro Leu 
            660                 665                 670         


Ala Gln Leu Tyr Cys His Ser Ile Met Glu His His His Phe Asp Gln 
        675                 680                 685             


Cys Leu Met Ile Leu Asn Ser Pro Gly Asn Gln Ile Leu Ser Gly Leu 
    690                 695                 700                 


Ser Ile Glu Glu Tyr Lys Thr Thr Leu Lys Ile Ile Lys Gln Ala Ile 
705                 710                 715                 720 


Leu Ala Thr Asp Leu Ala Leu Tyr Ile Lys Arg Arg Gly Glu Phe Phe 
                725                 730                 735     


Glu Leu Ile Arg Lys Asn Gln Phe Asn Leu Glu Asp Pro His Gln Lys 
            740                 745                 750         


Glu Leu Phe Leu Ala Met Leu Met Thr Ala Cys Asp Leu Ser Ala Ile 
        755                 760                 765             


Thr Lys Pro Trp Pro Ile Gln Gln Arg Ile Ala Glu Leu Val Ala Thr 
    770                 775                 780                 


Glu Phe Phe Asp Gln Gly Asp Arg Glu Arg Lys Glu Leu Asn Ile Glu 
785                 790                 795                 800 


Pro Thr Asp Leu Met Asn Arg Glu Lys Lys Asn Lys Ile Pro Ser Met 
                805                 810                 815     


Gln Val Gly Phe Ile Asp Ala Ile Cys Leu Gln Leu Tyr Glu Ala Leu 
            820                 825                 830         


Thr His Val Ser Glu Asp Cys Phe Pro Leu Leu Asp Gly Cys Arg Lys 
        835                 840                 845             


Asn Arg Gln Lys Trp Gln Ala Leu Ala Glu Gln Gln Glu Lys Met Leu 
    850                 855                 860                 


Ile Asn Gly Glu Ser Gly Gln Ala Lys Arg Asn 
865                 870                 875 


<210> 10
<211> 2625
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      construct"

<400> 10
atggagcggg ccggccccag cttcgggcag cagcgacagc agcagcagcc ccagcagcag       60

aagcagcagc agagggatca ggactcggtc gaagcatggc tggacggtca ctgggacttt      120

accttctcat actttgttag aaaagccacc agagaaatgg tcaatgcatg gtttgctgag      180

agagttcaca ccatccctgt gtgcaaggaa ggtatcagag gccacaccga atcttgctct      240

tgtcccttgc agcagagtcc tcgtgcagat aacagtgtcc ctggaacacc aaccaggaaa      300

atctctgcct ctgaatttga ccggcctctt agacccattg ttgtcaagga ttctgaggga      360

actgtgagct tcctctctga ctcagaaaag aaggaacaga tgcctctaac ccctccaagg      420

tttgatcatg atgaagggga ccagtgctca agactcttgg aattagtgaa ggatatttct      480

agtcatttgg atgtcacagc cttatgtcac aaaattttct tgcatatcca tggactgata      540

tctgctgacc gctattccct gttccttgtc tgtgaagaca gctccaatga caagtttctt      600

atcagccgcc tctttgatgt tgctgaaggt tcaacactgg aagaagtttc aaataactgt      660

atccgcttag aatggaacaa aggcattgtg ggacatgtgg cagcgcttgg tgagcccttg      720

aacatcaaag atgcatatga ggatcctcgg ttcaatgcag aagttgacca aattacaggc      780

tacaagacac aaagcattct ttgtatgcca attaagaatc atagggaaga ggttgttggt      840

gtagcccagg ccatcaacaa gaaatcagga aacggtggga catttactga aaaagatgaa      900

aaggactttg ctgcttattt ggcattttgt ggtattgttc ttcataatgc tcagctctat      960

gagacttcac tgctggagaa caagagaaat caggtgctgc tcgaccttgc tagtttaatt     1020

tttgaagaac aacaatcatt agaagtaatt ttgaagaaaa tagctgccac tattatctct     1080

ttcatgcaag tgcagaaatg caccattttc atagtggatg aagattgctc cgattctttt     1140

tctagtgtgt ttcacatgga gtgtgaggaa ttagaaaaat catctgatac attaacaagg     1200

gaacatgatg caaacaaaat caattacatg tatgctcagt acgtcaaaaa tactatggaa     1260

ccacttaata tcccagatgt cagtaaggat aaaagatttc cctggacaac tgaaaataca     1320

ggaaatgtaa accagcagtg cattagaagt ttgctttgta cacctataaa aaatggaaag     1380

aagaataaag ttataggggt ttgccaactt gttaataaga tggaggagaa tactggcaag     1440

gttaaacctt tcaaccgaaa tgacgaacag tttctggaag cttttgtcat cttttgtggc     1500

ttggggatcc agaacacgca gatgtatgaa gcagtggaga gagccatggc caagcaaatg     1560

gtcacattgg aggttctgtc gtatcatgct tcagcagcag aggaagaaac aagagagcta     1620

cagtcgttag cggctgctgt ggtgccatct gcccagaccc ttaaaattac tgactttagc     1680

ttcagtgact ttgagctgtc tgatctggaa acagcactgt gtacaattcg gatgtttact     1740

gacctcaacc ttgtgcagaa cttccggatg aaacatgagg ttctttgcag atggatttta     1800

agtgttaaga agaattatcg gaagaatgtt gcctatcata attggagaca tgcctttaat     1860

acagctcagt gcatgtttgc cgctctaaaa gcaggcaaaa ttcagaacaa gctgactgac     1920

ctggagatac ttgcattgct gattgctgca ctaagccacg atttggatca ccgtggtgtg     1980

aataactctt acatacagcg aagtgaacat ccacttgccc agctttactg ccattcaatc     2040

atggaacacc atcattttga ccagtgcctg atgattctta atagtccagg caatcagatt     2100

ctcagtggcc tctccattga agaatataag accacgttga aaataatcaa gcaagctatt     2160

ttagctacag acctagcact gtacattaag aggcgaggag aattttttga acttataaga     2220

aaaaatcaat tcaatttgga agatcctcat caaaaggagt tgtttttggc aatgctgatg     2280

acagcttgtg atctttctgc aattacaaaa ccctggccta ttcaacaacg gatagcggaa     2340

cttgtagcaa ctgaattttt tgatcaagga gacagagaga gaaaagaact caacatagaa     2400

cccactgatc taatgaacag ggagaagaaa aacaaaatcc caagtatgca agttgggttc     2460

atagatgcca tctgcttgca actgtatgag gccctgaccc acgtgtcaga ggactgtttc     2520

cctttgctag atggctgcag aaagaacagg cagaaatggc aggcccttgc agaacagcag     2580

gagaagatgc tgattaatgg ggaaagcggc caggccaagc ggaac                     2625


<210> 11
<211> 326
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Destabilizing Domain (DD)"

<400> 11
Glu Glu Thr Arg Glu Leu Gln Ser Leu Ala Ala Ala Val Val Pro Ser 
1               5                   10                  15      


Ala Gln Thr Leu Lys Ile Thr Asp Phe Ser Phe Ser Asp Phe Glu Leu 
            20                  25                  30          


Ser Asp Leu Glu Thr Ala Leu Cys Thr Ile Arg Met Phe Thr Asp Leu 
        35                  40                  45              


Asn Leu Val Gln Asn Phe Gln Met Lys His Glu Val Leu Cys Arg Trp 
    50                  55                  60                  


Ile Leu Ser Val Lys Lys Asn Tyr Arg Lys Asn Val Ala Tyr His Asn 
65                  70                  75                  80  


Trp Arg His Ala Phe Asn Thr Ala Gln Cys Met Phe Ala Ala Leu Lys 
                85                  90                  95      


Ala Gly Lys Ile Gln Asn Lys Leu Thr Asp Leu Glu Ile Leu Ala Leu 
            100                 105                 110         


Leu Ile Ala Ala Leu Ser His Asp Leu Asp His Arg Gly Val Asn Asn 
        115                 120                 125             


Ser Tyr Ile Gln Arg Ser Glu His Pro Leu Ala Gln Leu Tyr Cys His 
    130                 135                 140                 


Ser Ile Met Glu His His His Phe Asp Gln Cys Leu Met Ile Leu Asn 
145                 150                 155                 160 


Ser Pro Gly Asn Gln Ile Leu Ser Gly Leu Ser Ile Glu Glu Tyr Lys 
                165                 170                 175     


Thr Thr Leu Lys Ile Ile Lys Gln Ala Ile Leu Ala Thr Asp Leu Ala 
            180                 185                 190         


Leu Tyr Ile Lys Arg Arg Gly Glu Phe Phe Glu Leu Ile Arg Lys Asn 
        195                 200                 205             


Gln Phe Asn Leu Glu Asp Pro His Gln Lys Glu Leu Phe Leu Ala Met 
    210                 215                 220                 


Leu Met Thr Ala Cys Asp Leu Ser Ala Ile Thr Lys Pro Trp Pro Ile 
225                 230                 235                 240 


Gln Gln Arg Ile Ala Glu Leu Val Ala Thr Glu Phe Phe Asp Gln Gly 
                245                 250                 255     


Asp Arg Glu Arg Lys Glu Leu Asn Ile Glu Pro Thr Asp Leu Met Asn 
            260                 265                 270         


Arg Glu Lys Lys Asn Lys Ile Pro Ser Met Gln Val Gly Phe Ile Asp 
        275                 280                 285             


Ala Ile Cys Leu Gln Leu Tyr Glu Ala Leu Thr His Val Ser Glu Asp 
    290                 295                 300                 


Cys Phe Pro Leu Leu Asp Gly Cys Arg Lys Asn Arg Gln Lys Trp Gln 
305                 310                 315                 320 


Ala Leu Ala Glu Gln Gln 
                325     


<210> 12
<211> 978
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Destabilizing Domain (DD)"

<400> 12
gaagaaacaa gagagctaca gtcgttagcg gctgctgtgg tgccatctgc ccagaccctt       60

aaaattactg actttagctt cagtgacttt gagctgtctg atctggaaac agcactgtgt      120

acaattcgga tgtttactga cctcaacctt gtgcagaact tccggatgaa acatgaggtt      180

ctttgcagat ggattttaag tgttaagaag aattatcgga agaatgttgc ctatcataat      240

tggagacatg cctttaatac agctcagtgc atgtttgccg ctctaaaagc aggcaaaatt      300

cagaacaagc tgactgacct ggagatactt gcattgctga ttgctgcact aagccacgat      360

ttggatcacc gtggtgtgaa taactcttac atacagcgaa gtgaacatcc acttgcccag      420

ctttactgcc attcaatcat ggaacaccat cattttgacc agtgcctgat gattcttaat      480

agtccaggca atcagattct cagtggcctc tccattgaag aatataagac cacgttgaaa      540

ataatcaagc aagctatttt agctacagac ctagcactgt acattaagag gcgaggagaa      600

ttttttgaac ttataagaaa aaatcaattc aatttggaag atcctcatca aaaggagttg      660

tttttggcaa tgctgatgac agcttgtgat ctttctgcaa ttacaaaacc ctggcctatt      720

caacaacgga tagcggaact tgtagcaact gaattttttg atcaaggaga cagagagaga      780

aaagaactca acatagaacc cactgatcta atgaacaggg agaagaaaaa caaaatccca      840

agtatgcaag ttgggttcat agatgccatc tgcttgcaac tgtatgaggc cctgacccac      900

gtgtcagagg actgtttccc tttgctagat ggctgcagaa agaacaggca gaaatggcag      960

gcccttgcag aacagcag                                                    978


<210> 13
<211> 341
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Destabilizing Domain (DD)"

<400> 13
Glu Glu Thr Arg Glu Leu Gln Ser Leu Ala Ala Ala Val Val Pro Ser 
1               5                   10                  15      


Ala Gln Thr Leu Lys Ile Thr Asp Phe Ser Phe Ser Asp Phe Glu Leu 
            20                  25                  30          


Ser Asp Leu Glu Thr Ala Leu Cys Thr Ile Arg Met Phe Thr Asp Leu 
        35                  40                  45              


Asn Leu Val Gln Asn Phe Arg Met Lys His Glu Val Leu Cys Arg Trp 
    50                  55                  60                  


Ile Leu Ser Val Lys Lys Asn Tyr Arg Lys Asn Val Ala Tyr His Asn 
65                  70                  75                  80  


Trp Arg His Ala Phe Asn Thr Ala Gln Cys Met Phe Ala Ala Leu Lys 
                85                  90                  95      


Ala Gly Lys Ile Gln Asn Lys Leu Thr Asp Leu Glu Ile Leu Ala Leu 
            100                 105                 110         


Leu Ile Ala Ala Leu Ser His Asp Leu Asp His Arg Gly Val Asn Asn 
        115                 120                 125             


Ser Tyr Ile Gln Arg Ser Glu His Pro Leu Ala Gln Leu Tyr Cys His 
    130                 135                 140                 


Ser Ile Met Glu His His His Phe Asp Gln Cys Leu Met Ile Leu Asn 
145                 150                 155                 160 


Ser Pro Gly Asn Gln Ile Leu Ser Gly Leu Ser Ile Glu Glu Tyr Lys 
                165                 170                 175     


Thr Thr Leu Lys Ile Ile Lys Gln Ala Ile Leu Ala Thr Asp Leu Ala 
            180                 185                 190         


Leu Tyr Ile Lys Arg Arg Gly Glu Phe Phe Glu Leu Ile Arg Lys Asn 
        195                 200                 205             


Gln Phe Asn Leu Glu Asp Pro His Gln Lys Glu Leu Phe Leu Ala Met 
    210                 215                 220                 


Leu Met Thr Ala Cys Asp Leu Ser Ala Ile Thr Lys Pro Trp Pro Ile 
225                 230                 235                 240 


Gln Gln Arg Ile Ala Glu Leu Val Ala Thr Glu Phe Phe Asp Gln Gly 
                245                 250                 255     


Asp Arg Glu Arg Lys Glu Leu Asn Ile Glu Pro Thr Asp Leu Met Asn 
            260                 265                 270         


Arg Glu Lys Lys Asn Lys Ile Pro Ser Met Gln Val Gly Phe Ile Asp 
        275                 280                 285             


Ala Ile Cys Leu Gln Leu Tyr Glu Ala Leu Thr His Val Ser Glu Asp 
    290                 295                 300                 


Cys Phe Pro Leu Leu Asp Gly Cys Arg Lys Asn Arg Gln Lys Trp Gln 
305                 310                 315                 320 


Ala Leu Ala Glu Gln Gln Glu Lys Met Leu Ile Asn Gly Glu Ser Gly 
                325                 330                 335     


Gln Ala Lys Arg Asn 
            340     


<210> 14
<211> 1026
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Destabilizing Domain (DD)"

<400> 14
gaagaaacaa gagagctaca gtcgttagcg gctgctgtgg tgccatctgc ccagaccctt       60

aaaattactg actttagctt cagtgacttt gagctgtctg atctggaaac agcactgtgt      120

acaattcgga tgtttactga cctcaacctt gtgcagaact tccggatgaa acatgaggtt      180

ctttgcagat ggattttaag tgttaagaag aattatcgga agaatgttgc ctatcataat      240

tggagacatg cctttaatac agctcagtgc atgtttgccg ctctaaaagc aggcaaaatt      300

cagaacaagc tgactgacct ggagatactt gcattgctga ttgctgcact aagccacgat      360

ttggatcacc gtggtgtgaa taactcttac atacagcgaa gtgaacatcc acttgcccag      420

ctttactgcc attcaatcat ggaacaccat cattttgacc agtgcctgat gattcttaat      480

agtccaggca atcagattct cagtggcctc tccattgaag aatataagac cacgttgaaa      540

ataatcaagc aagctatttt agctacagac ctagcactgt acattaagag gcgaggagaa      600

ttttttgaac ttataagaaa aaatcaattc aatttggaag atcctcatca aaaggagttg      660

tttttggcaa tgctgatgac agcttgtgat ctttctgcaa ttacaaaacc ctggcctatt      720

caacaacgga tagcggaact tgtagcaact gaattttttg atcaaggaga cagagagaga      780

aaagaactca acatagaacc cactgatcta atgaacaggg agaagaaaaa caaaatccca      840

agtatgcaag ttgggttcat agatgccatc tgcttgcaac tgtatgaggc cctgacccac      900

gtgtcagagg actgtttccc tttgctagat ggctgcagaa agaacaggca gaaatggcag      960

gcccttgcag aacagcagga gaagatgctg attaatgggg aaagcggcca ggccaagcgg     1020

aactga                                                                1026


<210> 15
<211> 410
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Destabilizing Domain (DD)"

<400> 15
Gly Val Cys Gln Leu Val Asn Lys Met Glu Glu Asn Thr Gly Lys Val 
1               5                   10                  15      


Lys Pro Phe Asn Arg Asn Asp Glu Gln Phe Leu Glu Ala Phe Val Ile 
            20                  25                  30          


Phe Cys Gly Leu Gly Ile Gln Asn Thr Gln Met Tyr Glu Ala Val Glu 
        35                  40                  45              


Arg Ala Met Ala Lys Gln Met Val Thr Leu Glu Val Leu Ser Tyr His 
    50                  55                  60                  


Ala Ser Ala Ala Glu Glu Glu Thr Arg Glu Leu Gln Ser Leu Ala Ala 
65                  70                  75                  80  


Ala Val Val Pro Ser Ala Gln Thr Leu Lys Ile Thr Asp Phe Ser Phe 
                85                  90                  95      


Ser Asp Phe Glu Leu Ser Asp Leu Glu Thr Ala Leu Cys Thr Ile Arg 
            100                 105                 110         


Met Phe Thr Asp Leu Asn Leu Val Gln Asn Phe Arg Met Lys His Glu 
        115                 120                 125             


Val Leu Cys Arg Trp Ile Leu Ser Val Lys Lys Asn Tyr Arg Lys Asn 
    130                 135                 140                 


Val Ala Tyr His Asn Trp Arg His Ala Phe Asn Thr Ala Gln Cys Met 
145                 150                 155                 160 


Phe Ala Ala Leu Lys Ala Gly Lys Ile Gln Asn Lys Leu Thr Asp Leu 
                165                 170                 175     


Glu Ile Leu Ala Leu Leu Ile Ala Ala Leu Ser His Asp Leu Asp His 
            180                 185                 190         


Arg Gly Val Asn Asn Ser Tyr Ile Gln Arg Ser Glu His Pro Leu Ala 
        195                 200                 205             


Gln Leu Tyr Cys His Ser Ile Met Glu His His His Phe Asp Gln Cys 
    210                 215                 220                 


Leu Met Ile Leu Asn Ser Pro Gly Asn Gln Ile Leu Ser Gly Leu Ser 
225                 230                 235                 240 


Ile Glu Glu Tyr Lys Thr Thr Leu Lys Ile Ile Lys Gln Ala Ile Leu 
                245                 250                 255     


Ala Thr Asp Leu Ala Leu Tyr Ile Lys Arg Arg Gly Glu Phe Phe Glu 
            260                 265                 270         


Leu Ile Arg Lys Asn Gln Phe Asn Leu Glu Asp Pro His Gln Lys Glu 
        275                 280                 285             


Leu Phe Leu Ala Met Leu Met Thr Ala Cys Asp Leu Ser Ala Ile Thr 
    290                 295                 300                 


Lys Pro Trp Pro Ile Gln Gln Arg Ile Ala Glu Leu Val Ala Thr Glu 
305                 310                 315                 320 


Phe Phe Asp Gln Gly Asp Arg Glu Arg Lys Glu Leu Asn Ile Glu Pro 
                325                 330                 335     


Thr Asp Leu Met Asn Arg Glu Lys Lys Asn Lys Ile Pro Ser Met Gln 
            340                 345                 350         


Val Gly Phe Ile Asp Ala Ile Cys Leu Gln Leu Tyr Glu Ala Leu Thr 
        355                 360                 365             


His Val Ser Glu Asp Cys Phe Pro Leu Leu Asp Gly Cys Arg Lys Asn 
    370                 375                 380                 


Arg Gln Lys Trp Gln Ala Leu Ala Glu Gln Gln Glu Lys Met Leu Ile 
385                 390                 395                 400 


Asn Gly Glu Ser Gly Gln Ala Lys Arg Asn 
                405                 410 


<210> 16
<211> 1233
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Destabilizing Domain (DD)"

<400> 16
ggggtttgcc aacttgttaa taagatggag gagaatactg gcaaggttaa gcctttcaac       60

cgaaatgacg aacagtttct ggaagctttt gtcatctttt gtggcttggg gatccagaac      120

acgcagatgt atgaagcagt ggagagagcc atggccaagc aaatggtcac attggaggtt      180

ctgtcgtatc atgcttcagc agcagaggaa gaaacaagag agctacagtc gttagcggct      240

gctgtggtgc catctgccca gacccttaaa attactgact ttagcttcag tgactttgag      300

ctgtctgatc tggaaacagc actgtgtaca attcggatgt ttactgacct caaccttgtg      360

cagaacttcc ggatgaaaca tgaggttctt tgcagatgga ttttaagtgt taagaagaat      420

tatcggaaga atgttgccta tcataattgg agacatgcct ttaatacagc tcagtgcatg      480

tttgccgctc taaaagcagg caaaattcag aacaagctga ctgacctgga gatacttgca      540

ttgctgattg ctgcactaag ccacgatttg gatcaccgtg gtgtgaataa ctcttacata      600

cagcgaagtg aacatccact tgcccagctt tactgccatt caatcatgga acaccatcat      660

tttgaccagt gcctgatgat tcttaatagt ccaggcaatc agattctcag tggcctctcc      720

attgaagaat ataagaccac gttgaaaata atcaagcaag ctattttagc tacagaccta      780

gcactgtaca ttaagaggcg aggagaattt tttgaactta taagaaaaaa tcaattcaat      840

ttggaagatc ctcatcaaaa ggagttgttt ttggcaatgc tgatgacagc ttgtgatctt      900

tctgcaatta caaaaccctg gcctattcaa caacggatag cggaacttgt agcaactgaa      960

ttttttgatc aaggagacag agagagaaaa gaactcaaca tagaacccac tgatctaatg     1020

aacagggaga agaaaaacaa aatcccaagt atgcaagttg ggttcataga tgccatctgc     1080

ttgcaactgt atgaggccct gacccacgtg tcagaggact gtttcccttt gctagatggc     1140

tgcagaaaga acaggcagaa atggcaggcc cttgcagaac agcaggagaa gatgctgatt     1200

aatggggaaa gcggccaggc caagcggaac tga                                  1233


<210> 17
<211> 456
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Destabilizing Domain (DD)"

<400> 17
Glu Pro Leu Asn Ile Pro Asp Val Ser Lys Asp Lys Arg Phe Pro Trp 
1               5                   10                  15      


Thr Thr Glu Asn Thr Gly Asn Val Asn Gln Gln Cys Ile Arg Ser Leu 
            20                  25                  30          


Leu Cys Thr Pro Ile Lys Asn Gly Lys Lys Asn Lys Val Ile Gly Val 
        35                  40                  45              


Cys Gln Leu Val Asn Lys Met Glu Glu Asn Thr Gly Lys Val Lys Pro 
    50                  55                  60                  


Phe Asn Arg Asn Asp Glu Gln Phe Leu Glu Ala Phe Val Ile Phe Cys 
65                  70                  75                  80  


Gly Leu Gly Ile Gln Asn Thr Gln Met Tyr Glu Ala Val Glu Arg Ala 
                85                  90                  95      


Met Ala Lys Gln Met Val Thr Leu Glu Val Leu Ser Tyr His Ala Ser 
            100                 105                 110         


Ala Ala Glu Glu Glu Thr Arg Glu Leu Gln Ser Leu Ala Ala Ala Val 
        115                 120                 125             


Val Pro Ser Ala Gln Thr Leu Lys Ile Thr Asp Phe Ser Phe Ser Asp 
    130                 135                 140                 


Phe Glu Leu Ser Asp Leu Glu Thr Ala Leu Cys Thr Ile Arg Met Phe 
145                 150                 155                 160 


Thr Asp Leu Asn Leu Val Gln Asn Phe Arg Met Lys His Glu Val Leu 
                165                 170                 175     


Cys Arg Trp Ile Leu Ser Val Lys Lys Asn Tyr Arg Lys Asn Val Ala 
            180                 185                 190         


Tyr His Asn Trp Arg His Ala Phe Asn Thr Ala Gln Cys Met Phe Ala 
        195                 200                 205             


Ala Leu Lys Ala Gly Lys Ile Gln Asn Lys Leu Thr Asp Leu Glu Ile 
    210                 215                 220                 


Leu Ala Leu Leu Ile Ala Ala Leu Ser His Asp Leu Asp His Arg Gly 
225                 230                 235                 240 


Val Asn Asn Ser Tyr Ile Gln Arg Ser Glu His Pro Leu Ala Gln Leu 
                245                 250                 255     


Tyr Cys His Ser Ile Met Glu His His His Phe Asp Gln Cys Leu Met 
            260                 265                 270         


Ile Leu Asn Ser Pro Gly Asn Gln Ile Leu Ser Gly Leu Ser Ile Glu 
        275                 280                 285             


Glu Tyr Lys Thr Thr Leu Lys Ile Ile Lys Gln Ala Ile Leu Ala Thr 
    290                 295                 300                 


Asp Leu Ala Leu Tyr Ile Lys Arg Arg Gly Glu Phe Phe Glu Leu Ile 
305                 310                 315                 320 


Arg Lys Asn Gln Phe Asn Leu Glu Asp Pro His Gln Lys Glu Leu Phe 
                325                 330                 335     


Leu Ala Met Leu Met Thr Ala Cys Asp Leu Ser Ala Ile Thr Lys Pro 
            340                 345                 350         


Trp Pro Ile Gln Gln Arg Ile Ala Glu Leu Val Ala Thr Glu Phe Phe 
        355                 360                 365             


Asp Gln Gly Asp Arg Glu Arg Lys Glu Leu Asn Ile Glu Pro Thr Asp 
    370                 375                 380                 


Leu Met Asn Arg Glu Lys Lys Asn Lys Ile Pro Ser Met Gln Val Gly 
385                 390                 395                 400 


Phe Ile Asp Ala Ile Cys Leu Gln Leu Tyr Glu Ala Leu Thr His Val 
                405                 410                 415     


Ser Glu Asp Cys Phe Pro Leu Leu Asp Gly Cys Arg Lys Asn Arg Gln 
            420                 425                 430         


Lys Trp Gln Ala Leu Ala Glu Gln Gln Glu Lys Met Leu Ile Asn Gly 
        435                 440                 445             


Glu Ser Gly Gln Ala Lys Arg Asn 
    450                 455     


<210> 18
<211> 1371
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Destabilizing Domain (DD)"

<400> 18
gaaccactta atatcccaga tgtcagtaag gataaaagat ttccctggac aactgaaaat       60

acaggaaatg taaaccagca gtgcattaga agtttgcttt gtacacctat aaaaaatgga      120

aagaagaata aagttatagg ggtttgccaa cttgttaata agatggagga gaatactggc      180

aaggttaagc ctttcaaccg aaatgacgaa cagtttctgg aagcttttgt catcttttgt      240

ggcttgggga tccagaacac gcagatgtat gaagcagtgg agagagccat ggccaagcaa      300

atggtcacat tggaggttct gtcgtatcat gcttcagcag cagaggaaga aacaagagag      360

ctacagtcgt tagcggctgc tgtggtgcca tctgcccaga cccttaaaat tactgacttt      420

agcttcagtg actttgagct gtctgatctg gaaacagcac tgtgtacaat tcggatgttt      480

actgacctca accttgtgca gaacttccgg atgaaacatg aggttctttg cagatggatt      540

ttaagtgtta agaagaatta tcggaagaat gttgcctatc ataattggag acatgccttt      600

aatacagctc agtgcatgtt tgccgctcta aaagcaggca aaattcagaa caagctgact      660

gacctggaga tacttgcatt gctgattgct gcactaagcc acgatttgga tcaccgtggt      720

gtgaataact cttacataca gcgaagtgaa catccacttg cccagcttta ctgccattca      780

atcatggaac accatcattt tgaccagtgc ctgatgattc ttaatagtcc aggcaatcag      840

attctcagtg gcctctccat tgaagaatat aagaccacgt tgaaaataat caagcaagct      900

attttagcta cagacctagc actgtacatt aagaggcgag gagaattttt tgaacttata      960

agaaaaaatc aattcaattt ggaagatcct catcaaaagg agttgttttt ggcaatgctg     1020

atgacagctt gtgatctttc tgcaattaca aaaccctggc ctattcaaca acggatagcg     1080

gaacttgtag caactgaatt ttttgatcaa ggagacagag agagaaaaga actcaacata     1140

gaacccactg atctaatgaa cagggagaag aaaaacaaaa tcccaagtat gcaagttggg     1200

ttcatagatg ccatctgctt gcaactgtat gaggccctga cccacgtgtc agaggactgt     1260

ttccctttgc tagatggctg cagaaagaac aggcagaaat ggcaggccct tgcagaacag     1320

caggagaaga tgctgattaa tggggaaagc ggccaggcca agcggaactg a              1371


<210> 19
<211> 327
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Destabilizing Domain (DD)"

<400> 19
Met Glu Glu Thr Arg Glu Leu Gln Ser Leu Ala Ala Ala Val Val Pro 
1               5                   10                  15      


Ser Ala Gln Thr Leu Lys Ile Thr Asp Phe Ser Phe Ser Asp Phe Glu 
            20                  25                  30          


Leu Ser Asp Leu Glu Thr Ala Leu Cys Thr Ile Arg Met Phe Thr Asp 
        35                  40                  45              


Leu Asn Leu Val Gln Asn Phe Arg Met Lys His Glu Val Leu Cys Arg 
    50                  55                  60                  


Trp Ile Leu Ser Val Lys Lys Asn Tyr Arg Lys Asn Val Ala Tyr His 
65                  70                  75                  80  


Asn Trp Arg His Ala Phe Asn Thr Ala Gln Cys Met Phe Ala Ala Leu 
                85                  90                  95      


Lys Ala Gly Glu Ile Gln Asn Lys Leu Thr Asp Leu Glu Ile Leu Ala 
            100                 105                 110         


Leu Leu Ile Ala Ala Leu Ser His Asp Leu Asp His Arg Gly Val Asn 
        115                 120                 125             


Asn Ser Tyr Ile Gln Arg Ser Glu His Pro Leu Ala Gln Leu Tyr Cys 
    130                 135                 140                 


His Ser Ile Met Glu His His His Phe Asp Gln Cys Leu Met Ile Leu 
145                 150                 155                 160 


Asn Ser Pro Gly Asn Gln Ile Leu Ser Gly Leu Ser Ile Glu Glu Tyr 
                165                 170                 175     


Lys Thr Ser Leu Lys Ile Ile Lys Gln Ala Ile Leu Ala Thr Asp Leu 
            180                 185                 190         


Ala Leu Tyr Ile Lys Arg Arg Gly Glu Phe Phe Glu Leu Ile Arg Lys 
        195                 200                 205             


Asn Gln Phe Asn Leu Glu Asp Pro His Gln Lys Glu Leu Phe Leu Ala 
    210                 215                 220                 


Met Leu Met Thr Ala Cys Asp Leu Ser Ala Ile Thr Lys Pro Trp Pro 
225                 230                 235                 240 


Ile Gln Gln Arg Ile Ala Glu Leu Val Ala Thr Glu Phe Phe Asp Gln 
                245                 250                 255     


Gly Asp Arg Glu Arg Glu Glu Leu Asn Ile Glu Pro Thr Asp Leu Met 
            260                 265                 270         


Asn Arg Glu Lys Lys Asn Lys Ile Pro Ser Met Gln Val Gly Phe Ile 
        275                 280                 285             


Asp Ala Ile Cys Leu Gln Leu Tyr Glu Ala Leu Thr His Val Ser Glu 
    290                 295                 300                 


Asp Cys Phe Pro Leu Leu Asp Gly Cys Arg Lys Asn Arg Gln Glu Trp 
305                 310                 315                 320 


Gln Ala Leu Ala Glu Gln Gln 
                325         


<210> 20
<211> 327
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Destabilizing Domain (DD)"

<400> 20
Met Glu Gly Thr Arg Glu Leu Gln Ser Leu Ala Ala Ala Val Val Pro 
1               5                   10                  15      


Ser Ala Gln Thr Leu Lys Ile Thr Asp Phe Ser Phe Ser Asp Phe Glu 
            20                  25                  30          


Leu Ser Asp Leu Glu Thr Ala Leu Cys Thr Ile Arg Met Phe Thr Asp 
        35                  40                  45              


Leu Asn Leu Val Gln Asn Phe Arg Met Lys His Glu Val Leu Cys Arg 
    50                  55                  60                  


Trp Ile Leu Ser Val Lys Lys Asn Tyr Arg Lys Asn Val Ala Tyr His 
65                  70                  75                  80  


Asn Trp Arg His Ala Phe Asn Thr Ala Gln Cys Met Phe Ala Ala Leu 
                85                  90                  95      


Lys Ala Gly Lys Ile Gln Asn Lys Leu Thr Asp Leu Glu Ile Leu Ala 
            100                 105                 110         


Leu Leu Ile Ala Ala Leu Ser His Asp Leu Asp His Arg Gly Val Asn 
        115                 120                 125             


Asn Ser Tyr Ile Gln Arg Ser Glu His Pro Leu Ala Gln Leu Tyr Cys 
    130                 135                 140                 


His Ser Ile Met Glu His His His Phe Asp Gln Cys Leu Met Ile Leu 
145                 150                 155                 160 


Asn Ser Pro Gly Asn Gln Ile Leu Ser Gly Leu Ser Ile Glu Glu Tyr 
                165                 170                 175     


Lys Thr Thr Leu Lys Ile Ile Lys Gln Ala Ile Leu Ala Thr Asp Leu 
            180                 185                 190         


Ala Leu Tyr Ile Lys Arg Arg Gly Glu Phe Phe Glu Leu Ile Arg Lys 
        195                 200                 205             


Asn Gln Phe Asn Leu Glu Asp Pro His Gln Lys Glu Leu Phe Leu Ala 
    210                 215                 220                 


Met Leu Met Thr Ala Cys Asp Leu Ser Ala Ile Thr Lys Pro Trp Pro 
225                 230                 235                 240 


Ile Gln Gln Arg Ile Ala Glu Leu Val Ala Thr Glu Phe Phe Asp Gln 
                245                 250                 255     


Gly Asp Arg Glu Arg Lys Glu Leu Asn Ile Glu Pro Thr Asp Leu Met 
            260                 265                 270         


Asn Arg Glu Lys Lys Asn Lys Ile Pro Ser Met Gln Val Gly Phe Ile 
        275                 280                 285             


Asp Ala Ile Cys Leu Gln Leu Tyr Glu Ala Leu Thr His Val Ser Glu 
    290                 295                 300                 


Asp Ser Phe Pro Leu Leu Asp Gly Cys Arg Lys Asn Arg Gln Lys Trp 
305                 310                 315                 320 


Gln Ala Leu Ala Glu Gln Gln 
                325         


<210> 21
<211> 327
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Destabilizing Domain (DD)"

<400> 21
Met Glu Glu Thr Arg Glu Leu Gln Ser Leu Ala Ala Ala Val Val Pro 
1               5                   10                  15      


Ser Ala Gln Thr Leu Lys Ile Thr Asp Phe Ser Phe Ser Asp Phe Glu 
            20                  25                  30          


Leu Ser Asp Leu Glu Thr Ala Leu Cys Thr Ile Arg Met Phe Thr Asp 
        35                  40                  45              


Leu Asn Leu Val Gln Ser Phe Arg Met Lys His Glu Val Leu Cys Arg 
    50                  55                  60                  


Trp Ile Leu Ser Val Lys Lys Asn Tyr Arg Glu Asn Val Ala Tyr His 
65                  70                  75                  80  


Asn Trp Arg His Ala Phe Asn Thr Ala Gln Cys Met Phe Ala Ala Leu 
                85                  90                  95      


Lys Ala Gly Lys Ile Gln Asn Lys Leu Thr Asp Leu Glu Ile Leu Ala 
            100                 105                 110         


Leu Leu Ile Ala Ala Leu Ser His Asp Leu Asp His Arg Gly Val Ser 
        115                 120                 125             


Asn Ser Tyr Ile Gln Arg Ser Glu His Pro Leu Ala Gln Leu Tyr Cys 
    130                 135                 140                 


His Ser Ile Met Glu His His His Phe Asp Gln Cys Leu Met Ile Leu 
145                 150                 155                 160 


Asn Ser Pro Gly Asn Gln Ile Leu Ser Gly Leu Ser Ile Glu Glu Tyr 
                165                 170                 175     


Lys Thr Thr Leu Lys Ile Ile Lys Gln Ala Ile Leu Ala Thr Asp Leu 
            180                 185                 190         


Ala Leu Tyr Ile Lys Arg Arg Gly Glu Phe Phe Glu Leu Ile Arg Lys 
        195                 200                 205             


Asn Gln Phe Asn Leu Glu Asp Pro His Gln Lys Glu Leu Phe Leu Ala 
    210                 215                 220                 


Met Leu Met Thr Ala Cys Val Leu Ser Ala Ile Thr Lys Pro Trp Pro 
225                 230                 235                 240 


Ile Gln Gln Arg Ile Ala Glu Leu Val Ala Thr Glu Phe Phe Asp Gln 
                245                 250                 255     


Gly Asp Arg Glu Arg Lys Glu Leu Asn Ile Glu Pro Thr Asp Leu Met 
            260                 265                 270         


Asn Arg Glu Lys Lys Asn Lys Ile Pro Ser Met Gln Val Gly Phe Ile 
        275                 280                 285             


Asp Ala Ile Cys Leu Gln Leu Tyr Glu Ala Leu Thr His Val Ser Glu 
    290                 295                 300                 


Asp Cys Phe Pro Leu Leu Asp Gly Cys Arg Lys Asn Arg Gln Lys Trp 
305                 310                 315                 320 


Gln Ala Leu Ala Glu Gln Gln 
                325         


<210> 22
<211> 327
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Destabilizing Domain (DD)"

<400> 22
Met Glu Glu Thr Arg Glu Leu Gln Ser Leu Ala Ala Ala Val Val Pro 
1               5                   10                  15      


Ser Ala Gln Thr Leu Lys Ile Thr Asp Phe Ser Phe Ser Asp Phe Glu 
            20                  25                  30          


Leu Ser Asp Leu Glu Thr Ala Leu Cys Thr Ile Arg Met Phe Thr Asp 
        35                  40                  45              


Leu Asn Leu Val Gln Asn Phe Arg Met Lys His Glu Val Leu Cys Arg 
    50                  55                  60                  


Trp Ile Leu Ser Val Lys Lys Asn Tyr Arg Lys Asn Val Ala Tyr His 
65                  70                  75                  80  


Asn Trp Arg His Ala Phe Asn Thr Ala Gln Cys Met Phe Ala Ala Leu 
                85                  90                  95      


Lys Ala Gly Lys Ile Gln Asn Lys Leu Thr Asp Leu Glu Ile Leu Ala 
            100                 105                 110         


Leu Leu Ile Ala Ala Leu Ser His Asp Leu Asp His Arg Gly Val Asn 
        115                 120                 125             


Asn Ser Tyr Ile Gln Arg Ser Glu His Pro Leu Ala Gln Pro Tyr Cys 
    130                 135                 140                 


His Ser Ile Met Glu His His His Phe Asp Gln Cys Leu Met Ile Leu 
145                 150                 155                 160 


Asn Ser Pro Gly Asn Gln Ile Leu Ser Gly Leu Ser Ile Glu Glu Tyr 
                165                 170                 175     


Lys Thr Thr Leu Lys Ile Ile Lys Gln Ala Ile Leu Ala Thr Asp Leu 
            180                 185                 190         


Ala Leu Tyr Ile Lys Arg Arg Gly Glu Phe Phe Glu Leu Ile Arg Lys 
        195                 200                 205             


Asn Gln Phe Asn Leu Glu Asp Pro His Gln Lys Glu Leu Leu Leu Ala 
    210                 215                 220                 


Met Leu Met Thr Ala Cys Asp Leu Ser Ala Ile Thr Lys Pro Trp Pro 
225                 230                 235                 240 


Ile Gln Gln Arg Ile Ala Glu Leu Val Ala Thr Glu Phe Phe Asp Gln 
                245                 250                 255     


Gly Asp Arg Glu Arg Lys Glu Leu Asn Ile Glu Pro Thr Asp Leu Met 
            260                 265                 270         


Asn Arg Glu Lys Lys Asn Lys Ile Pro Ser Met Gln Val Gly Phe Ile 
        275                 280                 285             


Asp Ala Ile Cys Leu Gln Leu Tyr Glu Ala Leu Thr His Val Ser Glu 
    290                 295                 300                 


Asp Cys Phe Pro Leu Leu Asp Gly Cys Arg Lys Asn Arg Gln Lys Trp 
305                 310                 315                 320 


Gln Ala Leu Ala Glu Gln Gln 
                325         


<210> 23
<211> 326
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Destabilizing Domain (DD)"

<400> 23
Glu Glu Thr Arg Glu Leu Gln Ser Leu Ala Ala Ala Val Val Pro Ser 
1               5                   10                  15      


Ala Gln Thr Leu Lys Ile Thr Asp Phe Ser Phe Ser Asp Phe Glu Leu 
            20                  25                  30          


Ser Asp Leu Glu Thr Ala Leu Cys Thr Ile Arg Met Phe Thr Asp Leu 
        35                  40                  45              


Asn Leu Val Gln Asn Phe Arg Met Lys His Glu Val Leu Cys Arg Trp 
    50                  55                  60                  


Ile Leu Ser Val Lys Lys Asn Tyr Arg Lys Asn Val Ala Tyr His Asn 
65                  70                  75                  80  


Trp Arg His Ala Phe Asn Thr Ala Gln Cys Met Phe Ala Ala Leu Lys 
                85                  90                  95      


Ala Gly Lys Ile Gln Asn Lys Leu Thr Asp Leu Glu Ile Leu Ala Leu 
            100                 105                 110         


Leu Ile Ala Ala Leu Ser His Asp Leu Asp His Arg Gly Val Asn Asn 
        115                 120                 125             


Ser Tyr Ile Gln Arg Ser Glu His Pro Leu Ala Gln Leu Tyr Cys His 
    130                 135                 140                 


Ser Ile Met Glu His His His Phe Ala Gln Cys Leu Met Ile Leu Asn 
145                 150                 155                 160 


Ser Pro Gly Asn Gln Ile Leu Ser Gly Leu Ser Ile Glu Glu Tyr Lys 
                165                 170                 175     


Thr Thr Leu Lys Ile Ile Lys Gln Ala Ile Leu Ala Thr Asp Leu Ala 
            180                 185                 190         


Leu Tyr Ile Lys Arg Arg Gly Glu Phe Phe Glu Leu Ile Arg Lys Asn 
        195                 200                 205             


Gln Phe Asn Leu Glu Asp Pro His Gln Lys Glu Leu Phe Leu Ala Met 
    210                 215                 220                 


Leu Met Thr Ala Cys Asn Leu Ser Ala Ile Thr Lys Pro Trp Pro Ile 
225                 230                 235                 240 


Gln Gln Arg Ile Ala Glu Leu Val Ala Thr Glu Phe Phe Asp Gln Gly 
                245                 250                 255     


Asp Arg Glu Arg Lys Glu Leu Asn Ile Glu Pro Thr Asp Leu Met Asn 
            260                 265                 270         


Arg Glu Lys Lys Asn Lys Ile Pro Cys Met Gln Val Gly Phe Ile Asp 
        275                 280                 285             


Ala Ile Cys Leu Gln Leu Tyr Glu Ala Leu Thr His Val Ser Glu Asp 
    290                 295                 300                 


Cys Phe Pro Leu Leu Asp Gly Cys Arg Lys Asn Arg Gln Lys Trp Gln 
305                 310                 315                 320 


Ala Leu Ala Glu Gln Gln 
                325     


<210> 24
<211> 326
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Destabilizing Domain (DD)"

<400> 24
Glu Glu Thr Arg Glu Leu Gln Ser Leu Ala Ala Ala Val Val Pro Ser 
1               5                   10                  15      


Ala Gln Thr Leu Lys Ile Thr Asp Phe Ser Phe Ser Asp Phe Glu Leu 
            20                  25                  30          


Ser Asp Leu Glu Thr Ala Leu Cys Thr Ile Arg Met Phe Thr Asp Leu 
        35                  40                  45              


Asn Leu Val Gln Asn Phe Arg Met Lys His Glu Val Leu Cys Arg Trp 
    50                  55                  60                  


Ile Leu Ser Val Lys Lys Asn Tyr Arg Lys Asn Val Ala Tyr His Asn 
65                  70                  75                  80  


Trp Arg His Ala Phe Asn Thr Ala Gln Cys Met Phe Ala Ala Leu Lys 
                85                  90                  95      


Ala Gly Lys Ile Gln Asn Lys Leu Thr Asp Leu Glu Ile Leu Ala Leu 
            100                 105                 110         


Leu Ile Ala Ala Leu Ser His Asp Leu Asp His Arg Gly Val Asn Asn 
        115                 120                 125             


Ser Tyr Ile Gln Arg Ser Glu His Pro Leu Ala Gln Leu Asp Cys His 
    130                 135                 140                 


Ser Ile Met Glu His His His Phe Asp Gln Cys Leu Met Ile Leu Asn 
145                 150                 155                 160 


Ser Pro Gly Asn Gln Ile Leu Ser Gly Leu Ser Ile Glu Glu Tyr Lys 
                165                 170                 175     


Thr Thr Leu Lys Ile Ile Lys Gln Ala Ile Leu Ala Thr Asp Leu Ala 
            180                 185                 190         


Leu Tyr Ile Lys Arg Arg Gly Glu Phe Phe Glu His Ile Arg Lys Asn 
        195                 200                 205             


Gln Phe Asn Leu Glu Asp Pro His Gln Lys Glu Leu Phe Leu Ala Met 
    210                 215                 220                 


Leu Met Thr Ala Cys Asp Leu Ser Ala Ile Thr Lys Pro Trp Pro Ile 
225                 230                 235                 240 


Gln Gln Arg Ile Ala Glu Leu Val Ala Thr Glu Phe Phe Asp Gln Gly 
                245                 250                 255     


Asp Arg Glu Arg Lys Glu Leu Asn Ile Glu Pro Thr Asp Leu Met Asn 
            260                 265                 270         


Arg Glu Lys Lys Asn Lys Ile Pro Ser Met Gln Val Gly Phe Ile Asp 
        275                 280                 285             


Ala Ile Cys Leu Gln Leu Tyr Glu Ala Leu Thr His Val Ser Glu Asp 
    290                 295                 300                 


Cys Phe Pro Leu Leu Asp Gly Cys Arg Lys Asn Arg Gln Lys Trp Gln 
305                 310                 315                 320 


Ala Leu Ala Glu Gln Gln 
                325     


<210> 25
<211> 326
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Destabilizing Domain (DD)"

<400> 25
Glu Glu Thr Arg Glu Leu Gln Ser Leu Ala Ala Ala Val Val Pro Ser 
1               5                   10                  15      


Ala Gln Thr Leu Lys Ile Thr Asp Phe Ser Phe Ser Asp Phe Glu Leu 
            20                  25                  30          


Ser Asp Leu Glu Thr Ala Leu Cys Thr Ile Arg Met Phe Thr Asp Leu 
        35                  40                  45              


Asn Leu Val Gln Asn Phe Arg Met Glu His Glu Val Leu Cys Arg Trp 
    50                  55                  60                  


Ile Leu Ser Val Lys Lys Asn Tyr Arg Lys His Val Ala Tyr His Asn 
65                  70                  75                  80  


Trp Arg His Ala Phe Asn Thr Ala Gln Cys Met Phe Ala Ala Leu Lys 
                85                  90                  95      


Ala Gly Lys Ile Gln Asn Lys Leu Thr Asp Leu Glu Ile Leu Ala Leu 
            100                 105                 110         


Leu Ile Ala Ala Leu Ser His Asp Leu Asp His Arg Gly Val Asn Asn 
        115                 120                 125             


Ser Tyr Ile Gln Arg Ser Glu His Pro Leu Ala Gln Leu Tyr Cys His 
    130                 135                 140                 


Ser Ile Met Glu His His His Phe Asp Gln Cys Leu Met Ile Leu Asn 
145                 150                 155                 160 


Ser Pro Gly Asn Gln Ile Leu Ser Gly Leu Ser Ile Glu Glu Tyr Lys 
                165                 170                 175     


Thr Thr Leu Lys Ile Ile Lys Gln Ala Ile Leu Ala Thr Asp Leu Ala 
            180                 185                 190         


Leu Tyr Ile Lys Arg Arg Gly Glu Phe Phe Glu Leu Ile Arg Lys Asn 
        195                 200                 205             


Gln Phe Asn Leu Glu Asp Pro His Gln Lys Glu Leu Phe Leu Ala Met 
    210                 215                 220                 


Leu Met Thr Ala Cys Val Leu Ser Ala Ile Thr Lys Pro Trp Pro Ile 
225                 230                 235                 240 


Gln Gln Arg Ile Ala Glu Leu Val Ala Thr Glu Phe Phe Asp Gln Gly 
                245                 250                 255     


Asp Arg Glu Arg Lys Glu Leu Asn Ile Glu Pro Thr Asp Leu Met Asn 
            260                 265                 270         


Arg Glu Lys Lys Asn Lys Ile Pro Ser Met Gln Val Gly Phe Ile Asp 
        275                 280                 285             


Ala Ile Cys Leu Gln Leu Tyr Glu Ala Leu Thr His Val Ser Glu Asp 
    290                 295                 300                 


Cys Phe Pro Leu Leu Asp Gly Cys Arg Lys Asn Arg Gln Lys Trp Gln 
305                 310                 315                 320 


Ala Leu Ala Glu Gln Gln 
                325     


<210> 26
<211> 326
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Destabilizing Domain (DD)"

<400> 26
Glu Glu Thr Arg Glu Leu Gln Ser Leu Ala Ala Ala Val Val Pro Ser 
1               5                   10                  15      


Ala Gln Thr Leu Lys Ile Thr Asp Phe Ser Phe Ser Asp Phe Glu Leu 
            20                  25                  30          


Ser Asp Leu Glu Thr Ala Leu Cys Thr Ile Arg Met Phe Thr Asp Leu 
        35                  40                  45              


Asn Leu Val Gln Asn Phe Arg Met Lys His Glu Val Leu Cys Arg Trp 
    50                  55                  60                  


Ile Leu Ser Val Lys Lys Asn Tyr Arg Lys Asn Val Ala Tyr His Asn 
65                  70                  75                  80  


Trp Arg His Ala Phe Asn Thr Ala Gln Cys Met Phe Ala Ala Leu Lys 
                85                  90                  95      


Ala Gly Lys Ile Gln Asn Lys Leu Thr Asp Leu Glu Ile Leu Ala Leu 
            100                 105                 110         


Leu Ile Ala Ala Leu Ser His Asp Leu Asp His Arg Gly Val Asn Asn 
        115                 120                 125             


Ser Tyr Ile Gln Arg Ser Glu His Pro Leu Ala Gln Leu Tyr Cys His 
    130                 135                 140                 


Ser Ile Met Glu His His His Phe Asp Gln Cys Leu Met Ile Leu Asn 
145                 150                 155                 160 


Ser Pro Gly Asn Gln Ile Leu Ser Gly Leu Ser Ile Glu Glu Tyr Lys 
                165                 170                 175     


Thr Thr Leu Lys Ile Ile Lys Gln Ala Ile Leu Ala Thr Asp Leu Ala 
            180                 185                 190         


Leu Tyr Ile Lys Arg Arg Gly Glu Phe Phe Glu Leu Ile Arg Lys Asn 
        195                 200                 205             


Gln Phe Asn Leu Glu Asp Pro His Gln Lys Glu Leu Phe Leu Ala Met 
    210                 215                 220                 


Leu Met Thr Ala Cys Gly Leu Ser Ala Ile Thr Lys Pro Trp Pro Ile 
225                 230                 235                 240 


Gln Gln Arg Ile Ala Glu Leu Val Ala Thr Glu Phe Phe Asp Gln Gly 
                245                 250                 255     


Asp Arg Glu Arg Lys Glu Leu Asn Ile Glu Pro Thr Asp Leu Met Asn 
            260                 265                 270         


Arg Glu Lys Lys Asn Lys Ile Pro Ser Met Gln Val Gly Phe Ile Asp 
        275                 280                 285             


Ala Ile Cys Leu Gln Leu Tyr Glu Ala Leu Thr His Val Ser Glu Asp 
    290                 295                 300                 


Cys Phe Pro Leu Leu Asp Gly Cys Arg Lys Asn Arg Gln Lys Trp Gln 
305                 310                 315                 320 


Ala Leu Ala Glu Gln Gln 
                325     


<210> 27
<211> 326
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Destabilizing Domain (DD)"

<400> 27
Glu Glu Thr Arg Glu Leu Gln Ser Leu Ala Ala Ala Val Val Pro Ser 
1               5                   10                  15      


Ala Gln Thr Leu Lys Ile Thr Asp Phe Ser Leu Ser Asp Phe Glu Leu 
            20                  25                  30          


Ser Asp Leu Glu Thr Ala Leu Cys Thr Ile Arg Met Phe Thr Asp Leu 
        35                  40                  45              


Asn Leu Val Gln Asn Phe Arg Met Lys His Glu Val Leu Cys Arg Trp 
    50                  55                  60                  


Ile Leu Ser Val Lys Glu Asn Tyr Arg Lys Asn Val Ala Tyr His Asn 
65                  70                  75                  80  


Trp Arg His Ala Phe Asn Thr Ala Gln Cys Met Phe Ala Ala Leu Lys 
                85                  90                  95      


Ala Gly Lys Ile Gln Asn Lys Leu Thr Asp Leu Glu Ile Leu Ala Leu 
            100                 105                 110         


Leu Ile Ala Ala Leu Ser His Asp Leu Asp His Arg Gly Val Asn Asn 
        115                 120                 125             


Ser Tyr Ile Gln Arg Ser Glu His Pro Leu Ala Gln Leu Tyr Cys His 
    130                 135                 140                 


Ser Ile Met Glu His His His Phe Asp Gln Cys Leu Met Ile Leu Asn 
145                 150                 155                 160 


Ser Pro Gly Asn Gln Ile Leu Ser Gly Leu Ser Ile Glu Glu Tyr Lys 
                165                 170                 175     


Thr Thr Leu Lys Ile Ile Lys Gln Ala Ile Leu Ala Thr Asn Leu Ala 
            180                 185                 190         


Leu Tyr Ile Lys Arg Arg Gly Glu Phe Phe Glu Leu Ile Arg Lys Asn 
        195                 200                 205             


Gln Phe Asn Leu Glu Asp Pro His Gln Lys Glu Leu Phe Leu Ala Met 
    210                 215                 220                 


Leu Met Thr Ala Cys Asp Leu Ser Ala Ile Thr Lys Pro Trp Pro Ile 
225                 230                 235                 240 


Gln Gln Arg Ile Ala Glu Leu Val Ala Thr Glu Phe Phe Asp Gln Gly 
                245                 250                 255     


Asp Arg Glu Arg Lys Glu Phe Asn Ile Glu Pro Thr Asp Leu Met Asn 
            260                 265                 270         


Arg Glu Lys Lys Asn Lys Ile Pro Ser Met Gln Val Gly Phe Ile Asp 
        275                 280                 285             


Ala Ile Cys Leu Gln Leu Tyr Glu Ala Leu Thr His Val Ser Glu Asp 
    290                 295                 300                 


Cys Phe Pro Leu Leu Asp Gly Cys Arg Lys Asn Arg Gln Lys Trp Gln 
305                 310                 315                 320 


Ala Leu Ala Glu Gln Gln 
                325     


<210> 28
<211> 326
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Destabilizing Domain (DD)"

<400> 28
Asp Glu Thr Arg Glu Leu Gln Ser Leu Ala Ala Ala Val Val Pro Ser 
1               5                   10                  15      


Ala Gln Thr Leu Arg Ile Thr Asp Phe Ser Phe Ser Asp Ser Glu Leu 
            20                  25                  30          


Ser Asp Leu Glu Thr Ala Leu Cys Thr Ile Arg Met Phe Thr Asp Leu 
        35                  40                  45              


Asn Leu Val Gln Asn Phe Arg Met Lys His Glu Val Leu Cys Arg Trp 
    50                  55                  60                  


Ile Leu Ser Val Lys Lys Asn Tyr Arg Lys Asn Val Ala Tyr His Asn 
65                  70                  75                  80  


Trp Arg His Ala Phe Asn Thr Ala Gln Cys Met Phe Ala Ala Leu Arg 
                85                  90                  95      


Ala Gly Lys Ile Gln Asn Lys Leu Thr Asp Leu Glu Ile Leu Ala Leu 
            100                 105                 110         


Leu Ile Ala Ala Leu Ser His Asp Leu Asp His Arg Gly Val Asn Asn 
        115                 120                 125             


Ser Tyr Ile Gln Arg Ser Glu His Pro Leu Ala Gln Leu Tyr Arg His 
    130                 135                 140                 


Ser Ile Met Glu His His His Phe Asp Gln Cys Leu Met Ile Leu Asn 
145                 150                 155                 160 


Ser Pro Gly Asn Gln Ile Leu Ser Gly Leu Ser Ile Glu Glu Tyr Lys 
                165                 170                 175     


Thr Thr Leu Lys Ile Ile Lys Gln Ala Ile Leu Ala Thr Asp Leu Ala 
            180                 185                 190         


Leu Tyr Ile Lys Arg Arg Gly Glu Phe Phe Glu Leu Ile Arg Lys Ser 
        195                 200                 205             


Gln Phe Asn Leu Glu Asp Pro His Gln Lys Glu Leu Phe Leu Ala Met 
    210                 215                 220                 


Leu Met Thr Ala Cys Asp Leu Ser Ala Ile Thr Lys Pro Trp Pro Ile 
225                 230                 235                 240 


Gln Gln Arg Ile Ala Glu Leu Val Ala Thr Glu Phe Phe Asp Gln Gly 
                245                 250                 255     


Asp Arg Glu Arg Lys Glu Leu Asn Thr Glu Pro Thr Asp Leu Met Asn 
            260                 265                 270         


Arg Glu Lys Lys Asn Lys Ile Pro Ser Ala Gln Val Gly Phe Ile Asp 
        275                 280                 285             


Ala Ile Cys Leu Gln Leu Tyr Glu Ala Leu Thr His Val Ser Glu Asp 
    290                 295                 300                 


Cys Phe Pro Leu Leu Asp Gly Cys Arg Lys Asn Arg Gln Lys Trp Gln 
305                 310                 315                 320 


Ala Leu Ala Glu Gln Gln 
                325     


<210> 29
<211> 326
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Destabilizing Domain (DD)"

<400> 29
Glu Glu Thr Arg Glu Leu Gln Ser Leu Ala Ala Ala Val Val Pro Ser 
1               5                   10                  15      


Ala Gln Thr Leu Lys Ile Thr Asp Phe Ser Phe Ser Asp Phe Glu Leu 
            20                  25                  30          


Ser Asp Leu Glu Thr Ala Leu Cys Thr Ile Arg Met Phe Thr Asp Leu 
        35                  40                  45              


Asn Leu Val Gln Asn Phe Arg Met Lys His Glu Val Leu Cys Arg Trp 
    50                  55                  60                  


Ile Leu Ser Val Lys Lys Asn Tyr Arg Lys His Val Ala Tyr His Asn 
65                  70                  75                  80  


Trp Arg His Ala Phe Asn Thr Ala Gln Cys Met Phe Ala Ala Leu Lys 
                85                  90                  95      


Ala Gly Lys Ile Gln Asn Lys Leu Thr Asp Leu Glu Ile Leu Ala Leu 
            100                 105                 110         


Leu Ile Ala Ala Leu Ser His Asp Leu Asp His Arg Gly Val Asn Asn 
        115                 120                 125             


Ser Tyr Ile Gln Arg Ser Glu His Pro Leu Ala Gln Leu Asn Cys His 
    130                 135                 140                 


Ser Ile Met Glu His His His Phe Asp Gln Cys Leu Met Ile Leu Asn 
145                 150                 155                 160 


Ser Pro Gly Asn Gln Ile Leu Ser Gly Leu Ser Ile Glu Glu Tyr Lys 
                165                 170                 175     


Thr Thr Leu Lys Ile Ile Lys Gln Ala Ile Leu Ala Thr Asp Leu Ala 
            180                 185                 190         


Leu Tyr Ile Lys Arg Arg Gly Glu Phe Phe Glu Leu Ile Arg Lys Asn 
        195                 200                 205             


Gln Phe Asn Leu Glu Asp Pro His Gln Lys Glu Leu Phe Leu Ala Met 
    210                 215                 220                 


Leu Met Thr Ser Cys Asp Leu Ser Ala Ile Thr Lys Pro Trp Pro Ile 
225                 230                 235                 240 


Gln Gln Arg Ile Ala Glu Leu Val Ala Thr Glu Phe Phe Asp Gln Gly 
                245                 250                 255     


Asp Arg Glu Arg Lys Glu Leu Asn Ile Glu Pro Thr Asp Leu Met Asn 
            260                 265                 270         


Arg Glu Lys Lys Asn Lys Ile Pro Ser Met Gln Val Gly Phe Ile Asp 
        275                 280                 285             


Ala Ile Cys Leu Gln Leu Tyr Glu Ala Leu Thr His Val Ser Glu Asp 
    290                 295                 300                 


Cys Phe Pro Leu Leu Asp Gly Cys Arg Lys Asn Arg Gln Lys Trp Gln 
305                 310                 315                 320 


Ala Leu Ala Glu Gln Gln 
                325     


<210> 30
<211> 326
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Destabilizing Domain (DD)"

<400> 30
Glu Glu Thr Arg Glu Leu Gln Ser Leu Ala Ala Ala Val Val Pro Ser 
1               5                   10                  15      


Ala Gln Thr Leu Lys Ile Thr Asp Phe Ser Phe Ser Asp Phe Glu Leu 
            20                  25                  30          


Ser Asp Leu Glu Thr Ala Leu Cys Thr Ile Arg Met Phe Thr Asp Leu 
        35                  40                  45              


Asn Leu Val Gln Asn Phe Arg Met Lys His Glu Val Leu Cys Arg Trp 
    50                  55                  60                  


Ile Leu Ser Val Lys Lys Asn Tyr Arg Lys Asn Val Ala Tyr His Asn 
65                  70                  75                  80  


Trp Arg His Ala Phe Asn Thr Ala Gln Cys Met Phe Ala Ala Leu Lys 
                85                  90                  95      


Ala Gly Lys Ile Gln Ser Lys Leu Thr Asp Leu Glu Ile Leu Ala Leu 
            100                 105                 110         


Leu Ile Ala Ala Leu Ser His Asp Leu Asp His Arg Gly Val Asn Asn 
        115                 120                 125             


Ser Tyr Ile Gln Arg Ser Glu His Pro Leu Ala Gln Leu Tyr Cys His 
    130                 135                 140                 


Ser Ile Met Glu His His His Phe Ala Gln Cys Leu Met Ile Leu Asn 
145                 150                 155                 160 


Ser Pro Gly Asn Gln Ile Leu Ser Gly Leu Ser Ile Glu Glu Tyr Lys 
                165                 170                 175     


Thr Thr Leu Lys Ile Ile Lys Gln Ala Ile Leu Ala Thr Asp Leu Ala 
            180                 185                 190         


Leu Tyr Ile Lys Arg Arg Gly Glu Phe Phe Glu Leu Ile Arg Lys Asn 
        195                 200                 205             


Gln Phe Asn Leu Glu Asp Pro His Gln Lys Glu Leu Phe Leu Ala Met 
    210                 215                 220                 


Leu Met Thr Ala Cys Asn Leu Ser Ala Ile Thr Lys Pro Trp Pro Ile 
225                 230                 235                 240 


Gln Gln Arg Ile Ala Glu Leu Val Ala Thr Glu Phe Phe Asp Gln Gly 
                245                 250                 255     


Asp Arg Glu Arg Lys Glu Leu Asn Ile Glu Pro Thr Asp Leu Met Asn 
            260                 265                 270         


Arg Glu Lys Lys Asn Lys Ile Pro Cys Met Gln Val Gly Phe Ile Asp 
        275                 280                 285             


Ala Ile Cys Leu Gln Leu Tyr Glu Ala Leu Thr His Val Ser Glu Asp 
    290                 295                 300                 


Cys Phe Pro Leu Leu Asp Gly Cys Arg Lys Asn Arg Gln Lys Trp Gln 
305                 310                 315                 320 


Ala Leu Ala Glu Gln Gln 
                325     


<210> 31
<211> 326
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Destabilizing Domain (DD)"

<400> 31
Glu Glu Thr Arg Glu Leu Gln Ser Leu Ala Ala Ala Val Val Pro Ser 
1               5                   10                  15      


Ala Gln Thr Leu Lys Ile Thr Asp Phe Ser Phe Ser Asp Phe Glu Leu 
            20                  25                  30          


Ser Asp Leu Glu Thr Ala Leu Cys Thr Ile Arg Met Phe Thr Asp Leu 
        35                  40                  45              


Asn Leu Val Gln Asn Phe Arg Met Lys His Glu Val Leu Cys Arg Trp 
    50                  55                  60                  


Val Leu Ser Val Lys Lys Asn Tyr Arg Lys Asn Val Ala Tyr His Asn 
65                  70                  75                  80  


Trp Arg His Ala Phe Asn Thr Ala Gln Cys Met Phe Ala Ala Leu Lys 
                85                  90                  95      


Ala Gly Lys Ile Gln Asn Lys Leu Thr Asp Leu Glu Ile Leu Ala Leu 
            100                 105                 110         


Leu Ile Ala Ala Leu Ser His Asp Leu Asp His Arg Gly Val Asn Asn 
        115                 120                 125             


Ser Tyr Ile Gln Arg Ser Glu His Pro Leu Ala Gln Leu Tyr Cys His 
    130                 135                 140                 


Ser Ile Met Glu His His His Phe Asp Gln Cys Leu Met Ile Leu Asn 
145                 150                 155                 160 


Ser Pro Gly Asn Gln Ile Leu Ser Gly Leu Ser Ile Glu Glu Tyr Lys 
                165                 170                 175     


Ala Thr Leu Lys Ile Ile Lys Gln Ala Ile Leu Ala Thr Asp Leu Ala 
            180                 185                 190         


Leu Tyr Ile Lys Arg Arg Gly Glu Phe Phe Glu Leu Ile Arg Lys Asn 
        195                 200                 205             


Gln Leu Asn Ser Glu Asp Pro His Gln Lys Glu Leu Phe Leu Ala Met 
    210                 215                 220                 


Leu Met Thr Ala Cys Asp Leu Ser Ala Ile Thr Lys Pro Trp Pro Ile 
225                 230                 235                 240 


Gln Gln Arg Ile Ala Glu Leu Val Ala Thr Glu Phe Phe Asp Gln Gly 
                245                 250                 255     


Asp Arg Glu Arg Lys Glu Leu Asn Ile Glu Pro Thr Asp Pro Met Asn 
            260                 265                 270         


Arg Glu Lys Lys Asn Lys Ile Pro Ser Met Gln Val Gly Phe Ile Asp 
        275                 280                 285             


Ala Ile Cys Leu Gln Leu Tyr Glu Ala Leu Thr His Val Ser Glu Asp 
    290                 295                 300                 


Cys Phe Pro Leu Leu Asp Gly Cys Arg Lys Asn Arg Gln Lys Trp Gln 
305                 310                 315                 320 


Ala Leu Ala Glu Gln Gln 
                325     


<210> 32
<211> 326
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Destabilizing Domain (DD)"

<400> 32
Glu Glu Thr Arg Glu Leu Gln Ser Leu Ala Ala Ala Val Val Pro Ser 
1               5                   10                  15      


Ala Gln Thr Leu Lys Ile Thr Asp Phe Gly Phe Ser Asp Phe Glu Leu 
            20                  25                  30          


Ser Asp Leu Glu Thr Ala Leu Cys Thr Ile Arg Met Phe Thr Asp Leu 
        35                  40                  45              


Asn Leu Ala Gln Ser Phe Arg Met Glu His Glu Val Leu Cys Arg Trp 
    50                  55                  60                  


Ile Leu Ser Val Lys Lys Asn Tyr Arg Lys Asn Val Ala Tyr His Asn 
65                  70                  75                  80  


Trp Arg His Ala Phe Asn Thr Ala Gln Cys Met Phe Ala Ala Leu Lys 
                85                  90                  95      


Ala Gly Lys Ile Gln Asn Lys Leu Thr Asp Leu Glu Ile Leu Ala Leu 
            100                 105                 110         


Leu Ile Ala Ala Leu Ser His Asp Leu Asp His Arg Gly Val Asn Asn 
        115                 120                 125             


Pro Tyr Ile Gln Arg Ser Glu His Pro Leu Ala Gln Leu Tyr Cys His 
    130                 135                 140                 


Ser Ile Met Glu His His His Phe Asp Gln Cys Leu Met Ile Leu Asn 
145                 150                 155                 160 


Ser Pro Gly Asn Gln Ile Leu Ser Gly Leu Ser Ile Glu Glu Tyr Lys 
                165                 170                 175     


Thr Thr Leu Lys Ile Ile Lys Gln Ala Ile Leu Ala Thr Asp Leu Ala 
            180                 185                 190         


Leu Tyr Ile Lys Arg Arg Gly Glu Phe Phe Glu Leu Ile Arg Lys Asn 
        195                 200                 205             


Gln Phe Asn Leu Glu Asp Pro His Gln Lys Glu Leu Phe Leu Ala Met 
    210                 215                 220                 


Leu Met Thr Ala Cys Asp Leu Ser Ala Ile Thr Lys Pro Trp Pro Ile 
225                 230                 235                 240 


Gln Gln Arg Ile Ala Glu Leu Val Ala Thr Glu Phe Phe Asp Gln Gly 
                245                 250                 255     


Asp Arg Glu Arg Lys Glu Leu Asn Ile Glu Pro Thr Asp Leu Met Asn 
            260                 265                 270         


Arg Glu Lys Lys Asn Lys Ile Pro Ser Met Gln Val Gly Phe Ile Asp 
        275                 280                 285             


Ala Ile Cys Leu Gln Leu Tyr Glu Ala Leu Thr His Val Ser Glu Asp 
    290                 295                 300                 


Cys Ser Pro Leu Leu Asp Gly Cys Arg Lys Asn Arg Gln Lys Trp Gln 
305                 310                 315                 320 


Ala Leu Ala Glu Gln Gln 
                325     


<210> 33
<211> 326
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Destabilizing Domain (DD)"

<400> 33
Glu Glu Thr Arg Glu Leu Gln Ser Leu Ala Ala Ala Val Val Pro Ser 
1               5                   10                  15      


Ala Gln Thr Leu Lys Ile Thr Asp Phe Ser Phe Ser Asp Phe Glu Leu 
            20                  25                  30          


Ser Asp Leu Glu Thr Ala Leu Cys Thr Ile Arg Met Phe Thr Asp Leu 
        35                  40                  45              


Asn Leu Val Gln Asn Phe Arg Met Lys His Glu Val Leu Cys Arg Trp 
    50                  55                  60                  


Ile Leu Ser Val Lys Lys Asn Tyr Arg Lys Asn Val Ala Tyr His Asn 
65                  70                  75                  80  


Trp Arg His Ala Phe Asn Thr Ala Gln Cys Met Phe Ala Ala Leu Lys 
                85                  90                  95      


Ala Gly Lys Ile Gln Asn Lys Leu Thr Asp Leu Glu Ile Leu Ala Leu 
            100                 105                 110         


Leu Val Ala Ala Leu Ser His Asp Leu Asp His Arg Gly Val Asn Asn 
        115                 120                 125             


Ser Tyr Ile Gln Arg Ser Glu His Pro Leu Ala Gln Leu Tyr Cys His 
    130                 135                 140                 


Ser Ile Met Glu His His His Phe Asp Gln Cys Leu Met Ile Leu Asn 
145                 150                 155                 160 


Ser Pro Gly Asn Gln Ile Leu Ser Gly Leu Ser Ile Glu Glu Tyr Lys 
                165                 170                 175     


Thr Thr Leu Lys Ile Ile Lys Gln Ala Ile Leu Ala Thr Asp Leu Ala 
            180                 185                 190         


Leu Tyr Ile Lys Arg Arg Gly Glu Phe Phe Glu Leu Ile Arg Lys Asn 
        195                 200                 205             


Gln Phe Asn Leu Glu Asp Pro His Gln Lys Glu Leu Phe Leu Ala Met 
    210                 215                 220                 


Leu Met Thr Ala Cys Asp Leu Ser Ala Ile Thr Lys Pro Trp Pro Ile 
225                 230                 235                 240 


Gln Gln Arg Ile Ala Glu Leu Val Ala Thr Glu Phe Phe Asp Gln Gly 
                245                 250                 255     


Asp Arg Glu Arg Lys Glu Leu Asn Ile Glu Pro Thr Asp Leu Met Asn 
            260                 265                 270         


Arg Glu Lys Lys Asn Lys Ile Pro Ser Thr Gln Val Gly Phe Ile Asp 
        275                 280                 285             


Ala Ile Cys Leu Gln Leu Tyr Glu Ala Leu Thr His Val Ser Glu Asp 
    290                 295                 300                 


Cys Phe Pro Leu Leu Asp Gly Cys Arg Lys Asn Arg Gln Lys Trp Gln 
305                 310                 315                 320 


Ala Leu Ala Glu Gln Gln 
                325     


<210> 34
<211> 326
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Destabilizing Domain (DD)"

<400> 34
Glu Glu Thr Arg Glu Leu Gln Ser Leu Ala Ala Ala Val Val Pro Ser 
1               5                   10                  15      


Ala Gln Thr Leu Lys Ile Thr Asp Phe Ser Leu Ser Asp Leu Glu Leu 
            20                  25                  30          


Ser Asp Leu Glu Thr Ala Leu Cys Thr Ile Arg Met Phe Thr Asp Leu 
        35                  40                  45              


Asn Leu Val Gln Asn Phe Arg Met Lys His Glu Val Leu Cys Arg Trp 
    50                  55                  60                  


Ile Leu Ser Val Lys Lys Asn Tyr Arg Lys Asn Val Ala Tyr His Asn 
65                  70                  75                  80  


Trp Arg His Ala Phe Asn Thr Ala Gln Cys Met Phe Ala Ala Leu Lys 
                85                  90                  95      


Ala Gly Lys Ile Gln Asn Lys Leu Thr Asp Leu Glu Ile Leu Ala Leu 
            100                 105                 110         


Leu Ile Ala Ala Leu Ser His Asp Leu Asp His Arg Gly Val Asn Asn 
        115                 120                 125             


Ser Tyr Ile Gln Arg Ser Glu His Pro Leu Ala Gln Leu Tyr Cys His 
    130                 135                 140                 


Ser Ile Met Glu His His His Phe Asp Gln Cys Leu Met Ile Leu Asn 
145                 150                 155                 160 


Ser Pro Gly Asn Gln Ile Leu Ser Gly Leu Ser Ile Glu Glu Tyr Lys 
                165                 170                 175     


Thr Thr Leu Lys Ile Ile Lys Gln Ala Ile Leu Ala Thr Asn Leu Ala 
            180                 185                 190         


Leu Tyr Ile Lys Arg Arg Gly Glu Phe Phe Glu Leu Ile Arg Lys Asn 
        195                 200                 205             


Gln Phe Asn Leu Glu Asp Pro His Gln Lys Glu Leu Phe Leu Ala Met 
    210                 215                 220                 


Leu Met Thr Ala Cys Asp Leu Phe Ala Ile Thr Lys Pro Trp Pro Ile 
225                 230                 235                 240 


Gln Gln Arg Ile Ala Glu Leu Val Ala Thr Glu Phe Phe Asp Gln Gly 
                245                 250                 255     


Asp Arg Glu Arg Lys Glu Leu Asn Ile Glu Pro Pro Asp Leu Met Asn 
            260                 265                 270         


Arg Glu Lys Lys Asn Lys Ile Pro Ser Met Gln Val Gly Phe Ile Asp 
        275                 280                 285             


Ala Ile Cys Leu Gln Leu Tyr Glu Ala Leu Thr His Val Ser Glu Asp 
    290                 295                 300                 


Cys Phe Pro Leu Leu Asp Gly Cys Arg Lys Asn Arg Gln Lys Trp Gln 
305                 310                 315                 320 


Ala Leu Ala Glu Gln Gln 
                325     


<210> 35
<211> 326
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Destabilizing Domain (DD)"

<400> 35
Glu Glu Thr Arg Glu Leu Arg Ser Leu Ala Ala Ala Val Val Pro Ser 
1               5                   10                  15      


Ala Gln Thr Leu Lys Ile Thr Asp Leu Ser Phe Ser Asp Phe Glu Leu 
            20                  25                  30          


Ser Asp Leu Glu Thr Ala Leu Cys Thr Ile Arg Met Phe Thr Asp Leu 
        35                  40                  45              


Asn Leu Val Gln Asn Phe Arg Met Lys His Glu Val Leu Cys Arg Trp 
    50                  55                  60                  


Ile Leu Ser Val Lys Lys Asn Tyr Arg Lys Asn Val Ala Tyr His Asn 
65                  70                  75                  80  


Trp Arg His Ala Phe Asn Thr Ala Gln Cys Met Phe Ala Ala Leu Lys 
                85                  90                  95      


Ala Gly Lys Ile Gln Asn Lys Leu Thr Asp Leu Glu Ile Leu Ala Leu 
            100                 105                 110         


Leu Ile Ala Ala Leu Ser His Asp Leu Asp His Arg Gly Val Asn Asn 
        115                 120                 125             


Ser Tyr Ile Gln Arg Ser Glu His Pro Leu Ala Gln Leu Tyr Cys Arg 
    130                 135                 140                 


Ser Ile Met Glu His His His Phe Asp Gln Cys Leu Met Ile Leu Asn 
145                 150                 155                 160 


Ser Pro Gly Asn Gln Ile Leu Ser Gly Leu Ser Ile Glu Glu Tyr Lys 
                165                 170                 175     


Thr Thr Leu Lys Ile Ile Lys Gln Ala Ile Leu Ala Thr Asp Leu Ala 
            180                 185                 190         


Leu Tyr Ile Lys Arg Arg Gly Glu Phe Phe Glu Leu Ile Arg Lys Asn 
        195                 200                 205             


Gln Phe Asn Leu Glu Asp Pro His Gln Lys Glu Leu Phe Leu Ala Met 
    210                 215                 220                 


Leu Met Thr Ala Cys Asp Leu Ser Ala Ile Thr Lys Pro Trp Pro Ile 
225                 230                 235                 240 


Gln Gln Arg Ile Ala Glu Leu Val Ala Thr Glu Phe Phe Asp Gln Gly 
                245                 250                 255     


Asp Arg Glu Arg Lys Glu Leu Asn Ile Glu Pro Thr Asp Leu Met Asn 
            260                 265                 270         


Arg Glu Lys Lys Asn Lys Ile Pro Ser Met Gln Val Gly Phe Ile Asp 
        275                 280                 285             


Ala Thr Cys Leu Gln Leu Tyr Glu Ala Leu Thr His Val Ser Glu Asp 
    290                 295                 300                 


Cys Phe Pro Leu Leu Asp Gly Cys Arg Lys Asn Arg Gln Lys Trp Gln 
305                 310                 315                 320 


Ala Leu Ala Glu Gln Gln 
                325     


<210> 36
<211> 981
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Destabilizing Domain (DD)"

<400> 36
atggaagaaa caagagagct acagtcgtta gcggctgctg tggtgccatc tgcccagacc       60

cttaaaatta ctgactttag cttcagtgac tttgagctgt ctgatctgga aacagcactg      120

tgtacaattc ggatgtttac tgacctcaac cttgtgcaga acttccggat gaaacatgag      180

gttctttgca gatggatttt aagtgttaag aagaattatc ggaagaatgt tgcctatcat      240

aattggagac atgcctttaa tacagctcag tgcatgtttg ccgctctaaa agcaggcgaa      300

attcagaaca agctgactga cctggagata cttgcattgc tgattgctgc actaagccac      360

gatttggatc accgtggtgt gaataactct tacatacagc gaagtgaaca cccacttgcc      420

cagctttact gccattcaat catggaacac catcattttg accagtgcct gatgattctt      480

aatagtccag gcaatcagat tctcagtggc ctctccattg aagaatataa gacctcgttg      540

aaaataatca agcaagctat tttagctaca gacctagcac tgtacattaa gaggcgagga      600

gaattttttg aacttataag aaaaaatcaa ttcaatttgg aagatcctca tcaaaaggag      660

ttgtttttgg caatgctgat gacagcttgt gatctttctg caattacaaa accctggcca      720

attcaacaac ggatagcgga acttgtagca actgaatttt ttgatcaagg agacagagag      780

agagaagaac tcaacataga acccactgat ctaatgaaca gggagaagaa aaacaaaatc      840

ccaagtatgc aagttgggtt catagatgcc atctgcttgc aactgtatga ggccctgacc      900

cacgtgtcag aggactgttt ccctttgcta gatggctgca gaaagaacag gcaggaatgg      960

caggcccttg cagaacagca g                                                981


<210> 37
<211> 981
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Destabilizing Domain (DD)"

<400> 37
atggaaggaa caagagagct acagtcgtta gcggctgctg tggtgccatc tgcccagacc       60

cttaaaatta ctgactttag cttcagtgac tttgagctgt ctgatctgga aacagcactg      120

tgtacaattc ggatgtttac tgacctcaac cttgtgcaga acttccggat gaaacatgag      180

gttctttgca gatggatttt aagtgttaag aagaattatc ggaagaatgt tgcctatcat      240

aattggagac atgcctttaa tacagctcag tgcatgtttg ccgctctaaa agcaggcaaa      300

attcagaaca agctgactga cctggagata cttgcattgc tgattgctgc actaagccac      360

gatttggatc accgtggtgt gaataactct tacatacagc gaagtgaaca tccacttgcc      420

cagctttact gccattctat catggaacac catcattttg accagtgcct gatgattctt      480

aatagtccag gcaatcagat tctcagtggc ctctccattg aagaatataa gaccacgttg      540

aaaataatca agcaagctat tttagcaaca gacctagcac tgtacattaa gaggcgagga      600

gaattttttg aacttataag aaaaaatcaa ttcaatttgg aagatcctca tcaaaaggag      660

ttgtttttgg caatgctgat gacagcttgt gatctttctg caattacaaa accctggcct      720

attcaacaac ggatagcgga acttgtagca actgaatttt ttgatcaagg agacagagag      780

agaaaagaac tcaacataga acccactgat ctaatgaaca gggagaagaa aaacaaaatc      840

ccaagtatgc aagttgggtt catagacgcc atctgcttgc aactgtatga ggccctgacc      900

cacgtgtcag aggacagttt ccctttgcta gatggctgca gaaagaacag gcagaaatgg      960

caggcccttg cagaacagca g                                                981


<210> 38
<211> 981
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Destabilizing Domain (DD)"

<400> 38
atggaagaaa caagagagct acagtcgtta gcggctgctg tggtgccatc tgcccagacc       60

cttaaaatta ctgactttag cttcagtgac tttgagctgt ctgatctgga aacagcactg      120

tgtacaattc ggatgtttac tgacctcaac cttgtgcaga gcttccggat gaaacatgag      180

gttctttgca gatggatttt aagtgttaag aagaattatc gggagaatgt tgcctatcat      240

aattggagac atgcctttaa tacagctcag tgcatgtttg ccgctctaaa agcaggcaaa      300

attcagaaca agctgactga cctggagata cttgcattgc tgattgctgc actaagccac      360

gatttggatc accgtggtgt gagtaactct tacatacagc gaagtgaaca tccacttgcc      420

cagctttact gccattcaat catggaacac catcattttg accagtgcct gatgattctt      480

aatagtccag gcaatcagat tctcagtggc ctctccattg aagaatataa gaccacgttg      540

aaaataatca agcaagctat tttagctaca gacctagcac tgtacattaa gaggcgagga      600

gaattttttg aacttataag aaaaaatcaa ttcaatttgg aagatcctca tcaaaaggag      660

ttgtttttgg caatgctgat gacagcttgt gttctttctg caattacaaa accctggcct      720

attcaacaac ggatagcgga acttgtagca actgaatttt ttgatcaagg agacagagag      780

agaaaagaac tcaacataga acccactgat ctaatgaaca gggagaagaa aaacaaaatc      840

ccaagtatgc aagttgggtt catagatgcc atctgcttgc aactgtatga ggccctgacc      900

cacgtgtcag aggactgttt ccctttgcta gatggctgca gaaagaacag gcagaaatgg      960

caggcccttg cagaacagca g                                                981


<210> 39
<211> 981
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Destabilizing Domain (DD)"

<400> 39
atggaagaaa caagagagct acagtcgtta gcggctgctg tggtgccatc tgcccagacc       60

cttaaaatta ctgactttag cttcagtgac tttgagctgt ctgatctgga aacagcactg      120

tgtacaattc ggatgtttac tgacctcaac cttgtgcaga acttccggat gaaacatgag      180

gttctttgca gatggatttt aagtgttaag aagaattatc ggaagaatgt tgcctatcat      240

aattggagac atgcctttaa tacagctcag tgcatgtttg ccgctctaaa agcaggcaaa      300

attcagaaca agctgactga cctggagata cttgcattgc tgattgctgc actaagccac      360

gatttggatc accgtggtgt gaataactct tacatacagc gaagtgaaca tccacttgcc      420

cagccttact gccattcaat catggaacac catcattttg accagtgcct gatgattctt      480

aatagtccag gcaatcagat tctcagtggc ctctccattg aagaatataa gaccacgttg      540

aaaataatca agcaagctat tttagctaca gacctagcac tgtacattaa gaggcgagga      600

gaattttttg aacttataag aaaaaatcaa ttcaatttgg aagatcctca tcaaaaggag      660

ttgttgttgg caatgctgat gacagcttgt gatctttctg caattacaaa accctggcct      720

attcaacaac ggatagcgga actcgtagca actgaatttt ttgatcaagg agacagagag      780

agaaaagaac tcaacataga acccactgat ctaatgaaca gggagaagaa aaacaaaatc      840

ccaagtatgc aagttgggtt catagatgcc atctgcttgc aactgtatga ggccctgacc      900

cacgtgtcag aggactgttt ccctttgcta gatggctgca gaaagaacag gcagaaatgg      960

caggcccttg cagaacagca g                                                981


<210> 40
<211> 978
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Destabilizing Domain (DD)"

<400> 40
gaagaaacaa gagagctaca gtcgctagcg gctgctgtgg tgccatctgc ccagaccctt       60

aaaattactg actttagctt cagtgacttt gagctgtctg atctggaaac agcactgtgt      120

acaattcgga tgtttactga cctcaacctt gtgcagaact tccggatgaa acatgaggtt      180

ctttgcagat ggattttaag tgttaagaag aattatcgga agaatgttgc ctatcataat      240

tggagacatg cctttaatac agctcagtgc atgtttgccg ctctaaaagc aggcaaaatt      300

cagaacaagc tgactgacct ggagatactt gcattgctga ttgctgcact aagccacgat      360

ttggatcacc gtggtgtgaa taactcttac atacagcgaa gtgaacatcc acttgcccag      420

ctttactgcc attcaatcat ggaacaccat cattttgccc agtgcctgat gattcttaat      480

agtccaggca atcagattct cagtggcctc tccattgaag aatataagac cacgttgaaa      540

ataatcaagc aagctatttt agctacagac ctagcactgt acattaagag gcgaggagaa      600

ttttttgaac ttataagaaa aaatcaattc aatttggaag atcctcatca gaaggagttg      660

tttttggcaa tgctgatgac agcttgtaat ctttctgcaa ttacaaaacc ctggcctatt      720

caacaacgga tagcggaact tgtagcaact gaattttttg atcaaggaga cagagagaga      780

aaagaactca acatagaacc cactgatcta atgaacaggg agaagaaaaa caaaatccca      840

tgtatgcaag ttgggttcat agatgccatc tgcttgcaac tgtatgaggc cctgacccac      900

gtgtcagagg actgtttccc tttgctagat ggctgcagaa agaacaggca gaaatggcag      960

gcccttgcag aacagcag                                                    978


<210> 41
<211> 978
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Destabilizing Domain (DD)"

<400> 41
gaagaaacaa gagagctaca gtcgttagcg gctgctgtgg tgccatctgc ccagaccctt       60

aaaattactg actttagctt cagtgacttt gagctgtctg atctggaaac agcactgtgt      120

acaattcgga tgtttactga cctcaacctt gtgcagaact tccggatgaa acatgaggtt      180

ctttgcagat ggattttaag tgttaagaag aattatcgga agaatgttgc ctatcataat      240

tggagacatg cctttaatac agctcagtgc atgtttgccg ctctaaaagc aggcaaaatt      300

cagaacaagc tgactgacct ggagatactt gcattgctga ttgctgcact aagccacgat      360

ttggatcacc gtggtgtgaa taactcttac atacagcgaa gtgaacatcc acttgcccag      420

cttgactgcc attcaatcat ggaacaccat cactttgacc agtgcctgat gattcttaat      480

agtccaggca atcagattct cagtggcctc tccattgaag aatataagac cacgttgaaa      540

ataatcaagc aagctatttt agctacagac ctagcactgt acattaagag gcgaggagaa      600

ttttttgaac atataagaaa aaatcaattc aatttggaag atcctcatca aaaggagttg      660

tttttggcaa tgctgatgac agcttgtgat ctttctgcaa ttacaaaacc ctggcctatt      720

caacaacgga tagcggaact tgtagcaact gaattttttg atcaaggaga cagagagaga      780

aaagaactca acatagaacc cactgatcta atgaacaggg agaagaaaaa caaaatccca      840

agtatgcaag ttgggttcat agatgccatc tgcttgcaac tgtatgaggc cctgacccac      900

gtgtcagagg actgtttccc tttgctagat ggctgcagaa agaacaggca gaaatggcag      960

gcccttgcag aacagcag                                                    978


<210> 42
<211> 978
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Destabilizing Domain (DD)"

<400> 42
gaagaaacaa gagagctaca gtcgttagcg gctgctgtgg tgccatctgc ccagaccctt       60

aaaattactg actttagctt cagtgacttt gagctgtctg atctggaaac agcactgtgt      120

acaattcgga tgtttactga cctcaacctt gtgcagaact tccggatgga acatgaggtt      180

ctttgcagat ggattttaag tgttaagaag aattatcgga agcatgttgc ctatcataat      240

tggagacatg cctttaatac agctcagtgc atgtttgccg ctctaaaagc aggcaaaatt      300

cagaacaagc tgactgacct ggagatactt gcattgctga ttgctgcact aagccacgat      360

ttggatcacc gtggtgtgaa taactcttac atacagcgaa gtgaacatcc acttgcccag      420

ctttactgcc attcaatcat ggaacaccat cattttgacc agtgcctgat gattcttaat      480

agtccaggca atcagatact cagtggcctc tccattgaag aatataagac cacgttgaaa      540

ataatcaagc aagctatttt agcaacagac ctagcactgt acattaagag gcgaggagaa      600

ttttttgaac ttataagaaa aaatcaattc aatttggaag atcctcatca aaaggagttg      660

tttttggcaa tgctgatgac agcttgtgtt ctttctgcaa ttacaaaacc ctggcctatt      720

caacaacgga tagcggaact tgtagcaact gaattttttg atcaaggaga cagagagaga      780

aaagaactca acatagaacc cactgattta atgaacaggg agaagaaaaa caaaatccca      840

agtatgcaag ttgggttcat agatgccatc tgcttgcaac tgtatgaggc cctgacccac      900

gtgtcagagg actgtttccc tttgctagat ggctgcagaa agaacaggca gaaatggcag      960

gcccttgcag aacagcag                                                    978


<210> 43
<211> 978
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Destabilizing Domain (DD)"

<400> 43
gaagaaacaa gagagctaca gtcgttagcg gctgctgtgg tgccatctgc ccagaccctt       60

aaaattactg actttagctt cagtgacttt gagctgtctg atctggaaac agcactgtgt      120

acaattcgga tgtttactga cctcaacctt gtgcagaact tccggatgaa acatgaggtt      180

ctttgcagat ggattttaag tgttaagaag aattatcgga agaatgttgc ctatcataat      240

tggagacatg cctttaatac agctcagtgc atgtttgccg ctctaaaagc aggcaaaatt      300

cagaacaagc tgactgacct ggagatactt gcattgctga ttgctgcact aagccacgat      360

ttggatcacc gtggtgtgaa taactcttac atacagcgaa gtgaacatcc acttgcccag      420

ctttactgcc attcaatcat ggaacaccat cattttgacc agtgcctgat gattcttaat      480

agtccaggca atcagattct cagtggcctc tccattgaag aatataagac cacgttgaaa      540

ataatcaagc aagctatttt agctacagac ctagcactgt acattaagag gcgaggagaa      600

ttttttgaac ttataagaaa aaatcaattc aatttggaag atcctcatca aaaggagttg      660

tttttggcaa tgctgatgac agcttgtggt ctttctgcaa ttacaaaacc ctggcctatt      720

caacaacgga tagcggaact tgtagcaact gaattttttg atcaaggaga cagagagaga      780

aaagaactca acatagaacc cactgatcta atgaacaggg agaagaaaaa caaaatccca      840

agtatgcaag ttgggttcat agatgccatc tgcttgcaac tgtatgaggc cctgacccac      900

gtgtcagagg actgtttccc tttgctagat ggctgcagaa agaacaggca gaaatggcag      960

gcccttgcag aacagcag                                                    978


<210> 44
<211> 978
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Destabilizing Domain (DD)"

<400> 44
gaagaaacaa gagagctaca gtcgttagcg gctgctgtgg tgccatctgc ccagaccctt       60

aaaattactg actttagcct cagtgacttt gagctgtctg atctggaaac agcactgtgt      120

acaattcgga tgtttactga cctcaacctt gtgcagaact tccggatgaa acatgaggtt      180

ctttgcagat ggattttaag tgttaaggag aattatcgga agaatgttgc ctatcataat      240

tggagacatg cctttaatac agctcagtgc atgtttgccg ctctaaaagc aggcaaaatt      300

cagaacaagc tgactgacct ggagatactt gcattgctga ttgctgcact aagccacgat      360

ttggatcacc gtggtgtgaa taactcttac atacagcgaa gtgaacatcc acttgcccag      420

ctttactgcc attcaatcat ggaacaccat cattttgacc agtgcctgat gattcttaat      480

agtccaggca atcagattct cagtggcctc tccattgaag aatataagac cacgttgaaa      540

ataatcaagc aagctatttt agctacaaac ctagcactgt acattaagag gcgaggagaa      600

ttttttgaac ttataagaaa aaatcaattc aatttggaag atcctcatca aaaggagttg      660

tttttggcaa tgctgatgac agcttgtgat ctttctgcaa ttacaaaacc ctggcctatt      720

caacaacgga tagcggaact tgtagcaact gaattttttg atcaaggaga cagagagaga      780

aaagaattca acatagaacc cacagatcta atgaacaggg agaagaaaaa caaaatccca      840

agtatgcaag ttgggttcat agatgccatc tgcttgcaac tgtatgaggc cctgacccac      900

gtgtcagagg actgtttccc tttgctagat ggctgcagaa agaacaggca gaaatggcag      960

gcccttgcag aacagcag                                                    978


<210> 45
<211> 978
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Destabilizing Domain (DD)"

<400> 45
gacgaaacaa gagagctaca gtcgttagcg gctgctgtgg tgccatctgc ccagaccctt       60

agaattactg actttagctt cagtgactct gagctgtctg atctggaaac agcactgtgt      120

acaattcgga tgtttactga cctcaacctt gtgcagaact tccggatgaa acatgaggtt      180

ctttgcagat ggattttaag tgttaagaag aattatcgga agaatgttgc ctatcataat      240

tggagacatg cctttaatac agctcagtgc atgtttgccg ctctaagagc aggcaaaatt      300

cagaacaagc tgactgacct ggagatactt gcattgctga ttgctgcact aagccacgat      360

ttggatcacc gtggtgtgaa taactcttac atacagcgaa gtgaacatcc acttgcccag      420

ctttaccgcc attcaatcat ggaacaccat cattttgacc agtgcctgat gattcttaat      480

agtcccggca atcagattct cagtggcctc tccattgaag aatataagac cacgctgaaa      540

ataatcaagc aagctatttt agctacagac ctagcactgt acattaagag gcgaggagaa      600

ttttttgaac ttataagaaa aagtcaattc aatttggaag atcctcatca aaaggagttg      660

tttttggcaa tgctgatgac agcttgtgat ctttctgcaa ttacaaaacc ctggcctatt      720

caacaacgga tagcggaact tgtagcaact gaattttttg atcaagggga cagagagaga      780

aaagagctca acacagaacc cactgatcta atgaacaggg agaagaaaaa caaaatccca      840

agtgcgcaag ttgggttcat agatgccatc tgcttgcaac tgtatgaggc cctgacccac      900

gtgtcagagg actgtttccc tttgctagat ggctgcagaa agaacaggca gaaatggcag      960

gcccttgcag aacagcag                                                    978


<210> 46
<211> 978
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Destabilizing Domain (DD)"

<400> 46
gaagaaacaa gagagctaca gtcgttagcg gctgctgtgg tgccatctgc ccagaccctt       60

aaaattactg actttagctt cagtgacttt gagctgtctg atctggaaac agcactgtgt      120

acaattcgga tgtttactga cctcaacctt gtgcagaact tccggatgaa acatgaggtt      180

ctttgcagat ggattttaag tgttaagaag aattatcgga agcatgttgc ctatcataat      240

tggagacatg cctttaatac agctcagtgc atgtttgccg ctctaaaagc aggcaaaatt      300

cagaacaagc tgactgacct ggagatactt gcattgctga ttgctgcact aagccacgat      360

ttggatcacc gtggtgtgaa taactcttac atacagcgaa gtgaacatcc acttgcccag      420

cttaactgcc attcaatcat ggaacaccat cattttgacc agtgcctgat gattcttaat      480

agtccaggca atcagattct cagtggcctc tccattgaag aatataagac cacgttgaaa      540

ataatcaagc aagctatttt agctacagac ctagcactgt acattaagag gcgaggagaa      600

ttttttgaac ttataagaaa aaatcaattc aatttggaag atcctcatca aaaggagttg      660

tttttggcaa tgctgatgac atcttgtgat ctttctgcaa ttacaaaacc ctggcctatt      720

caacaacgga tagcggaact tgtagcaact gaattttttg atcaaggaga cagagagaga      780

aaagaactca acatagaacc cactgatcta atgaacaggg agaagaaaaa caaaatccca      840

agtatgcaag ttgggttcat agatgccatc tgcttgcaac tgtatgaggc cctgacccac      900

gtgtcagagg actgtttccc tttgctagat ggctgcagaa agaacaggca gaaatggcag      960

gcccttgcag aacagcag                                                    978


<210> 47
<211> 978
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Destabilizing Domain (DD)"

<400> 47
gaagaaacaa gagagctaca gtcgctagcg gctgctgtgg tgccatctgc ccagaccctt       60

aaaattactg actttagctt cagtgacttt gagctgtctg atctggaaac agcactgtgt      120

acaattcgga tgtttactga cctcaacctt gtgcagaact tccggatgaa acatgaggtt      180

ctttgcagat ggattttaag tgttaagaag aattatcgga agaatgttgc ctatcataat      240

tggagacatg cctttaatac agctcagtgc atgtttgccg ctctaaaagc aggcaaaatt      300

cagagcaagc tgactgacct ggagatactt gcattgctga ttgctgcact aagccacgat      360

ttggatcacc gtggtgtgaa taactcttac atacagcgaa gtgaacatcc acttgcccag      420

ctttactgcc attcaatcat ggaacaccat cattttgccc agtgcctgat gattcttaat      480

agtccaggca atcagattct cagtggcctc tccattgaag aatataagac cacgttgaaa      540

ataatcaagc aagctatttt agctacagac ctagcactgt acattaagag gcgaggagaa      600

ttttttgaac ttataagaaa aaatcaattc aatttggaag atcctcatca gaaggagttg      660

tttttggcaa tgctgatgac agcttgtaat ctttctgcaa ttacaaaacc ctggcctatt      720

caacaacgga tagcggaact tgtagcaact gaattttttg atcaaggaga cagagagaga      780

aaagaactca acatagaacc cactgatcta atgaacaggg agaagaaaaa caaaatccca      840

tgtatgcaag ttgggttcat agatgccatc tgcttgcaac tgtatgaggc cctgacccac      900

gtgtcagagg actgtttccc tttgctagat ggctgcagaa agaacaggca gaaatggcag      960

gcccttgcag aacagcag                                                    978


<210> 48
<211> 978
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Destabilizing Domain (DD)"

<400> 48
gaagaaacaa gagagctaca gtcgttagcg gctgctgtgg tgccatctgc ccagaccctt       60

aaaattactg actttagctt cagtgacttt gagctgtctg atctggaaac agcactgtgt      120

acaattcgga tgtttactga cctcaacctt gtgcagaact tccggatgaa acatgaggtt      180

ctttgcagat gggttttaag tgttaagaag aattatcgga agaatgttgc ctatcacaat      240

tggagacatg cctttaatac agctcagtgc atgtttgccg ctctaaaagc aggcaaaatt      300

cagaataagc tgactgacct ggagatactt gcattgctga ttgctgcact aagccacgat      360

ttggatcacc gtggtgtgaa taactcttac atacagcgaa gtgaacatcc acttgcccag      420

ctttactgcc attcaatcat ggaacaccat cattttgacc agtgcctgat gattcttaat      480

agtccaggca atcagattct cagtggcctc tccattgaag aatataaggc cacgttgaaa      540

ataatcaagc aagctatttt agctacagac ctagcactgt acattaagag gcgaggagaa      600

ttttttgaac ttataagaaa aaatcaactc aattcggaag atcctcatca aaaggagttg      660

tttttggcaa tgctgatgac agcttgtgat ctttctgcaa ttacaaaacc ctggcctatt      720

caacaacgga tagcggaact tgtagcaact gaattttttg atcaaggaga cagagagaga      780

aaagaactta acatagaacc cactgatcca atgaacaggg agaagaaaaa caaaatccca      840

agtatgcaag ttgggttcat agatgccatc tgcttgcaac tgtatgaggc cctgacccac      900

gtgtcagagg actgtttccc tttgctagat ggctgcagaa agaacaggca gaaatggcag      960

gcccttgcag aacagcag                                                    978


<210> 49
<211> 978
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Destabilizing Domain (DD)"

<400> 49
gaagaaacaa gagagctaca gtcgttagcg gctgctgtgg tgccatctgc ccagaccctt       60

aaaattactg actttggctt cagtgacttt gagctgtctg atctggaaac agcactgtgt      120

acaattcgga tgtttactga cctcaacctt gcgcagagct tccggatgga acatgaggtt      180

ctttgcagat ggattttaag tgttaagaag aattatcgga agaatgttgc ctatcataat      240

tggagacatg cctttaatac agctcagtgc atgtttgccg ctctaaaagc aggcaaaatt      300

cagaacaagc tgactgacct ggagatactt gcattgctga ttgctgcact aagccacgat      360

ttggatcacc gtggtgtgaa taacccttac atacagcgaa gtgaacatcc acttgcccag      420

ctttactgcc attcaatcat ggaacaccat cattttgacc agtgcctgat gattcttaat      480

agtccaggca atcagattct cagtggcctc tccattgaag aatataagac cacgttgaaa      540

ataatcaagc aagctatttt agctacagac ctagcactgt acattaagag gcgaggagaa      600

ttttttgaac ttataagaaa aaatcaattc aatttggaag atcctcatca aaaggagttg      660

tttttggcaa tgctgatgac agcttgtgat ctttctgcaa ttacaaaacc ctggcctatt      720

caacaacgga tagcggaact tgtagcaact gaattttttg atcaaggaga cagagagaga      780

aaagaactca acatagaacc cactgatcta atgaacaggg agaagaaaaa caaaatccca      840

agtatgcaag ttgggttcat agatgccatc tgcttgcaac tgtatgaggc cctgacccac      900

gtgtcagagg actgttcccc tttgctagat ggctgcagaa agaacaggca gaaatggcag      960

gcccttgcag aacagcag                                                    978


<210> 50
<211> 978
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Destabilizing Domain (DD)"

<400> 50
gaagaaacaa gagagctaca gtcgttagcg gctgctgtgg tgccatccgc ccagaccctt       60

aaaattactg actttagctt cagtgacttt gagctgtctg atctggaaac agcactgtgt      120

acaattcgga tgtttactga cctcaacctt gtgcagaact tccggatgaa acatgaggtt      180

ctttgcagat ggattttaag tgttaagaag aattatcgga agaatgttgc ctatcataat      240

tggagacatg cctttaatac agctcagtgc atgtttgccg ctctaaaagc aggcaaaatt      300

cagaacaagc tgactgacct ggagatactt gcattgctgg ttgctgcact aagccacgat      360

ttggaccacc gtggtgtgaa taactcttac atacagcgaa gtgaacatcc acttgcccag      420

ctttactgcc attcaatcat ggaacaccat cattttgacc agtgcctgat gattcttaat      480

agtccaggca atcaaattct cagtggcctc tccattgaag aatataagac cacgttgaaa      540

ataatcaagc aggctatttt agctacagac ctagcactgt acattaagag gcgaggagaa      600

ttttttgaac ttataagaaa aaatcaattc aatttggaag atcctcatca aaaggagttg      660

tttttggcaa tgctgatgac agcttgtgat ctttctgcaa ttacaaaacc ctggcctatt      720

caacaacgga tagcggaact tgtagcaact gaattttttg atcaaggaga cagagagaga      780

aaagaactca acatagaacc cactgatcta atgaacaggg agaagaaaaa caaaatccca      840

agtacgcaag ttgggttcat agatgccatc tgcttgcaac tgtatgaggc cctgacccac      900

gtgtcagagg actgtttccc tttgctagat ggctgcagaa agaacaggca gaaatggcag      960

gcccttgcag aacagcag                                                    978


<210> 51
<211> 978
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Destabilizing Domain (DD)"

<400> 51
gaagaaacaa gagagctaca gtcgttagcg gctgctgtgg tgccatctgc ccagaccctt       60

aaaattactg actttagcct cagtgacctt gagctgtctg atctggaaac agcactgtgt      120

acaattcgga tgtttactga cctcaacctt gtgcagaact tccggatgaa acatgaggtt      180

ctttgcagat ggattttaag tgttaagaag aattatcgga agaatgttgc ctatcataat      240

tggagacatg cctttaatac agctcagtgc atgtttgccg ctctaaaagc aggcaaaatt      300

cagaacaagc tgactgacct ggagatactt gcattgctga ttgctgcact aagccacgat      360

ttggatcacc gtggtgtgaa taactcttac atacagcgaa gtgaacatcc acttgcccag      420

ctttactgcc attcaatcat ggaacaccat cattttgacc agtgcctgat gattcttaat      480

agtccaggca atcagattct cagtggcctc tccattgaag aatataagac cacgttgaaa      540

ataatcaagc aagctatttt agctacaaac ctagcactgt acattaagag gcgaggagaa      600

ttttttgaac ttataagaaa aaatcaattc aatttggaag atcctcatca aaaggagttg      660

tttttggcaa tgctgatgac agcttgtgat ctttttgcaa ttacaaaacc ctggcctatt      720

caacaacgga tagcggaact tgtagcaact gaattttttg atcaaggaga cagagagaga      780

aaagaactca acatagaacc ccctgattta atgaacaggg agaagaaaaa caaaattcca      840

agtatgcaag ttgggttcat agatgccatc tgcttgcaac tgtatgaggc cctgacccac      900

gtgtcagagg actgtttccc tttgctagat ggctgcagaa agaacaggca gaaatggcag      960

gcccttgcag agcagcag                                                    978


<210> 52
<211> 978
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Destabilizing Domain (DD)"

<400> 52
gaagaaacaa gagagctacg gtcgttagcg gctgctgtgg tgccatctgc ccagaccctt       60

aaaattactg accttagctt cagtgacttt gagctgtctg atctggaaac agcactgtgt      120

acaattcgga tgtttactga cctcaacctt gtgcagaact tccggatgaa acatgaggtt      180

ctttgcagat ggattttaag tgttaagaag aattatcgga agaatgttgc ctatcataat      240

tggagacatg cctttaatac agctcagtgc atgtttgccg ctctaaaagc aggcaaaatt      300

cagaacaagc tgactgacct ggagatactt gcattgctga ttgctgcact aagccacgat      360

ttggatcacc gtggtgtgaa taactcttac atacagcgaa gtgaacatcc acttgcccag      420

ctttactgcc gttcaatcat ggaacaccat cattttgacc agtgcctgat gattcttaat      480

agtccaggca atcagattct cagtggcctc tccattgaag aatataagac cacgttgaaa      540

ataatcaagc aagctatttt agctacagac ctagcactgt acattaagag gcgaggagaa      600

ttttttgaac ttataagaaa aaatcaattc aatttggaag atcctcatca aaaggagttg      660

tttttggcaa tgctgatgac agcttgtgat ctttctgcaa ttacaaaacc ctggcctatt      720

caacaacgga tagcggaact tgtagcaact gaattttttg atcaaggaga cagagagaga      780

aaagaactca acatagaacc cactgattta atgaacaggg agaagaaaaa caaaatccca      840

agtatgcaag ttgggttcat agatgccacc tgcttgcaac tgtatgaggc cctgacccac      900

gtgtcagagg actgtttccc tttgctagat ggctgcagaa agaacaggca gaaatggcag      960

gcccttgcag aacagcag                                                    978


<210> 53
<211> 326
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Destabilizing Domain (DD)"

<400> 53
Glu Glu Thr Arg Glu Leu Gln Ser Leu Ala Ala Ala Val Val Pro Ser 
1               5                   10                  15      


Ala Gln Thr Leu Lys Ile Thr Asp Phe Ser Leu Ser Asp Phe Glu Leu 
            20                  25                  30          


Ser Asp Leu Glu Thr Ala Leu Cys Thr Ile Arg Met Phe Thr Asp Leu 
        35                  40                  45              


Asn Leu Val Gln Asn Phe Arg Met Lys His Glu Val Leu Cys Arg Trp 
    50                  55                  60                  


Ile Leu Ser Val Lys Glu Asn Tyr Arg Lys Asn Val Ala Tyr His Asn 
65                  70                  75                  80  


Trp Arg His Ala Phe Asn Thr Ala Gln Cys Met Phe Ala Ala Leu Lys 
                85                  90                  95      


Ala Gly Lys Ile Gln Asn Lys Leu Thr Asp Leu Glu Ile Leu Ala Leu 
            100                 105                 110         


Leu Ile Ala Ala Leu Ser His Asp Leu Asp His Arg Gly Val Asn Asn 
        115                 120                 125             


Ser Tyr Ile Gln Arg Ser Glu His Pro Leu Ala Gln Leu Tyr Cys His 
    130                 135                 140                 


Ser Ile Met Glu His His His Phe Asp Gln Cys Leu Met Ile Leu Asn 
145                 150                 155                 160 


Ser Pro Gly Asn Gln Ile Leu Ser Gly Leu Ser Ile Glu Glu Tyr Lys 
                165                 170                 175     


Thr Thr Leu Lys Ile Ile Lys Gln Ala Ile Leu Ala Thr Asn Leu Ala 
            180                 185                 190         


Leu Tyr Ile Lys Arg Arg Gly Glu Phe Phe Glu Leu Ile Arg Lys Asn 
        195                 200                 205             


Gln Phe Asn Leu Glu Asp Pro His Gln Lys Glu Leu Phe Leu Ala Met 
    210                 215                 220                 


Leu Met Thr Ala Cys Asn Leu Ser Ala Ile Thr Lys Pro Trp Pro Ile 
225                 230                 235                 240 


Gln Gln Arg Ile Ala Glu Leu Val Ala Thr Glu Phe Phe Asp Gln Gly 
                245                 250                 255     


Asp Arg Glu Arg Lys Glu Phe Asn Ile Glu Pro Thr Asp Leu Met Asn 
            260                 265                 270         


Arg Glu Lys Lys Asn Lys Ile Pro Ser Met Gln Val Gly Phe Ile Asp 
        275                 280                 285             


Ala Ile Cys Leu Gln Leu Tyr Glu Ala Leu Thr His Val Ser Glu Asp 
    290                 295                 300                 


Cys Phe Pro Leu Leu Asp Gly Cys Arg Lys Asn Arg Gln Lys Trp Gln 
305                 310                 315                 320 


Ala Leu Ala Glu Gln Gln 
                325     


<210> 54
<211> 978
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Destabilizing Domain (DD)"

<400> 54
gaagaaacaa gagagctaca gtcgttagcg gctgctgtgg tgccatctgc ccagaccctt       60

aaaattactg actttagcct cagtgacttt gagctgtctg atctggaaac agcactgtgt      120

acaattcgga tgtttactga cctcaacctt gtgcagaact tccggatgaa acatgaggtt      180

ctttgcagat ggattttaag tgttaaggag aattatcgga agaatgttgc ctatcataat      240

tggagacatg cctttaatac agctcagtgc atgtttgccg ctctaaaagc aggcaaaatt      300

cagaacaagc tgactgacct ggagatactt gcattgctga ttgctgcact aagccacgat      360

ttggatcacc gtggtgtgaa taactcttac atacagcgaa gtgaacatcc acttgcccag      420

ctttactgcc attcaatcat ggaacaccat cattttgacc agtgcctgat gattcttaat      480

agtccaggca atcagattct cagtggcctc tccattgaag aatataagac cacgttgaaa      540

ataatcaagc aagctatttt agctacaaac ctagcactgt acattaagag gcgaggagaa      600

ttttttgaac ttataagaaa aaatcaattc aatttggaag atcctcatca aaaggagttg      660

tttttggcaa tgctgatgac agcttgtaat ctttctgcaa ttacaaaacc ctggcctatt      720

caacaacgga tagcggaact tgtagcaact gaattttttg atcaaggaga cagagagaga      780

aaagaattta acatagaacc cacagatcta atgaacaggg agaagaaaaa caaaatccca      840

agtatgcaag ttgggttcat agatgccatc tgcttgcaac tgtatgaggc cctgacccac      900

gtgtcagagg actgtttccc tttgctagat ggctgcagaa agaacaggca gaaatggcag      960

gcccttgcag aacagcag                                                    978


<210> 55
<211> 326
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Destabilizing Domain (DD)"

<400> 55
Glu Glu Thr Arg Glu Leu Gln Ser Leu Ala Ala Ala Val Val Pro Ser 
1               5                   10                  15      


Ala Gln Thr Leu Lys Ile Thr Asp Phe Ser Leu Ser Asp Phe Glu Leu 
            20                  25                  30          


Ser Asp Leu Glu Thr Ala Leu Cys Thr Ile Arg Met Phe Thr Asp Leu 
        35                  40                  45              


Asn Leu Val Gln Asn Phe Arg Met Lys His Glu Val Leu Cys Arg Trp 
    50                  55                  60                  


Ile Leu Ser Val Lys Glu Asn Tyr Arg Lys Asn Val Ala Tyr His Asn 
65                  70                  75                  80  


Trp Arg His Ala Phe Asn Thr Ala Gln Cys Met Phe Ala Ala Leu Lys 
                85                  90                  95      


Ala Gly Lys Ile Gln Asn Lys Leu Thr Asp Leu Glu Ile Leu Ala Leu 
            100                 105                 110         


Leu Ile Ala Ala Leu Ser His Asp Leu Asp His Arg Gly Val Asn Asn 
        115                 120                 125             


Ser Tyr Ile Gln Arg Ser Glu His Pro Leu Ala Gln Leu Tyr Cys His 
    130                 135                 140                 


Ser Ile Met Glu His His His Phe Asp Gln Cys Leu Met Ile Leu Asn 
145                 150                 155                 160 


Ser Pro Gly Asn Gln Ile Leu Ser Gly Leu Ser Ile Glu Glu Tyr Lys 
                165                 170                 175     


Thr Thr Leu Lys Ile Ile Lys Gln Ala Ile Leu Ala Thr Asn Leu Ala 
            180                 185                 190         


Leu Tyr Ile Lys Arg Arg Gly Glu Phe Phe Glu Leu Ile Arg Lys Asn 
        195                 200                 205             


Gln Phe Asn Leu Glu Asp Pro His Gln Lys Glu Leu Phe Leu Ala Met 
    210                 215                 220                 


Leu Met Thr Ala Cys Gly Leu Ser Ala Ile Thr Lys Pro Trp Pro Ile 
225                 230                 235                 240 


Gln Gln Arg Ile Ala Glu Leu Val Ala Thr Glu Phe Phe Asp Gln Gly 
                245                 250                 255     


Asp Arg Glu Arg Lys Glu Phe Asn Ile Glu Pro Thr Asp Leu Met Asn 
            260                 265                 270         


Arg Glu Lys Lys Asn Lys Ile Pro Ser Met Gln Val Gly Phe Ile Asp 
        275                 280                 285             


Ala Ile Cys Leu Gln Leu Tyr Glu Ala Leu Thr His Val Ser Glu Asp 
    290                 295                 300                 


Cys Phe Pro Leu Leu Asp Gly Cys Arg Lys Asn Arg Gln Lys Trp Gln 
305                 310                 315                 320 


Ala Leu Ala Glu Gln Gln 
                325     


<210> 56
<211> 978
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Destabilizing Domain (DD)"

<400> 56
gaagaaacaa gagagctaca gtcgttagcg gctgctgtgg tgccatctgc ccagaccctt       60

aaaattactg actttagcct cagtgacttt gagctgtctg atctggaaac agcactgtgt      120

acaattcgga tgtttactga cctcaacctt gtgcagaact tccggatgaa acatgaggtt      180

ctttgcagat ggattttaag tgttaaggag aattatcgga agaatgttgc ctatcataat      240

tggagacatg cctttaatac agctcagtgc atgtttgccg ctctaaaagc aggcaaaatt      300

cagaacaagc tgactgacct ggagatactt gcattgctga ttgctgcact aagccacgat      360

ttggatcacc gtggtgtgaa taactcttac atacagcgaa gtgaacatcc acttgcccag      420

ctttactgcc attcaatcat ggaacaccat cattttgacc agtgcctgat gattcttaat      480

agtccaggca atcagattct cagtggcctc tccattgaag aatataagac cacgttgaaa      540

ataatcaagc aagctatttt agctacaaac ctagcactgt acattaagag gcgaggagaa      600

ttttttgaac ttataagaaa aaatcaattc aatttggaag atcctcatca aaaggagttg      660

tttttggcaa tgctgatgac agcttgtggt ctttctgcaa ttacaaaacc ctggcctatt      720

caacaacgga tagcggaact tgtagcaact gaattttttg atcaaggaga cagagagaga      780

aaagaattta acatagaacc cacagatcta atgaacaggg agaagaaaaa caaaatccca      840

agtatgcaag ttgggttcat agatgccatc tgcttgcaac tgtatgaggc cctgacccac      900

gtgtcagagg actgtttccc tttgctagat ggctgcagaa agaacaggca gaaatggcag      960

gcccttgcag aacagcag                                                    978


<210> 57
<211> 576
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Destabilizing Domain (DD)"

<400> 57
Met Val Ser Lys Gly Ala Glu Leu Phe Thr Gly Ile Val Pro Ile Leu 
1               5                   10                  15      


Ile Glu Leu Asn Gly Asp Val Asn Gly His Lys Phe Ser Val Ser Gly 
            20                  25                  30          


Glu Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile 
        35                  40                  45              


Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr 
    50                  55                  60                  


Leu Ser Tyr Gly Val Gln Cys Phe Ser Arg Tyr Pro Asp His Met Lys 
65                  70                  75                  80  


Gln His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Ile Gln Glu 
                85                  90                  95      


Arg Thr Ile Phe Phe Glu Asp Asp Gly Asn Tyr Lys Ser Arg Ala Glu 
            100                 105                 110         


Val Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Thr Gly 
        115                 120                 125             


Thr Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly Asn Lys Met Glu Tyr 
    130                 135                 140                 


Asn Tyr Asn Ala His Asn Val Tyr Ile Met Thr Asp Lys Ala Lys Asn 
145                 150                 155                 160 


Gly Ile Lys Val Asn Phe Lys Ile Arg His Asn Ile Glu Asp Gly Ser 
                165                 170                 175     


Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly 
            180                 185                 190         


Pro Val Leu Leu Pro Asp Asn His Tyr Leu Ser Thr Gln Ser Ala Leu 
        195                 200                 205             


Ser Lys Asp Pro Asn Glu Lys Arg Asp His Met Ile Tyr Phe Gly Phe 
    210                 215                 220                 


Val Thr Ala Ala Ala Ile Thr His Gly Met Asp Glu Leu Tyr Lys Glu 
225                 230                 235                 240 


Phe Tyr Pro Tyr Asp Val Pro Asp Tyr Ala Glu Glu Thr Arg Glu Leu 
                245                 250                 255     


Gln Ser Leu Ala Ala Ala Val Val Pro Ser Ala Gln Thr Leu Lys Ile 
            260                 265                 270         


Thr Asp Phe Ser Leu Ser Asp Phe Glu Leu Ser Asp Leu Glu Thr Ala 
        275                 280                 285             


Leu Cys Thr Ile Arg Met Phe Thr Asp Leu Asn Leu Val Gln Asn Phe 
    290                 295                 300                 


Arg Met Lys His Glu Val Leu Cys Arg Trp Ile Leu Ser Val Lys Glu 
305                 310                 315                 320 


Asn Tyr Arg Lys Asn Val Ala Tyr His Asn Trp Arg His Ala Phe Asn 
                325                 330                 335     


Thr Ala Gln Cys Met Phe Ala Ala Leu Lys Ala Gly Lys Ile Gln Asn 
            340                 345                 350         


Lys Leu Thr Asp Leu Glu Ile Leu Ala Leu Leu Ile Ala Ala Leu Ser 
        355                 360                 365             


His Asp Leu Asp His Arg Gly Val Asn Asn Ser Tyr Ile Gln Arg Ser 
    370                 375                 380                 


Glu His Pro Leu Ala Gln Leu Tyr Cys His Ser Ile Met Glu His His 
385                 390                 395                 400 


His Phe Asp Gln Cys Leu Met Ile Leu Asn Ser Pro Gly Asn Gln Ile 
                405                 410                 415     


Leu Ser Gly Leu Ser Ile Glu Glu Tyr Lys Thr Thr Leu Lys Ile Ile 
            420                 425                 430         


Lys Gln Ala Ile Leu Ala Thr Asn Leu Ala Leu Tyr Ile Lys Arg Arg 
        435                 440                 445             


Gly Glu Phe Phe Glu Leu Ile Arg Lys Asn Gln Phe Asn Leu Glu Asp 
    450                 455                 460                 


Pro His Gln Lys Glu Leu Phe Leu Ala Met Leu Met Thr Ala Cys Asp 
465                 470                 475                 480 


Leu Ser Ala Ile Thr Lys Pro Trp Pro Ile Gln Gln Arg Ile Ala Glu 
                485                 490                 495     


Leu Val Ala Thr Glu Phe Phe Asp Gln Gly Asp Arg Glu Arg Lys Glu 
            500                 505                 510         


Phe Asn Ile Glu Pro Thr Asp Leu Met Asn Arg Glu Lys Lys Asn Lys 
        515                 520                 525             


Ile Pro Ser Met Gln Val Gly Phe Ile Asp Ala Ile Cys Leu Gln Leu 
    530                 535                 540                 


Tyr Glu Ala Leu Thr His Val Ser Glu Asp Cys Phe Pro Leu Leu Asp 
545                 550                 555                 560 


Gly Cys Arg Lys Asn Arg Gln Lys Trp Gln Ala Leu Ala Glu Gln Gln 
                565                 570                 575     


<210> 58
<211> 1731
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Destabilizing Domain (DD)"

<400> 58
atggtgagca agggcgccga gctgttcacc ggcatcgtgc ccatcctgat cgagctgaat       60

ggcgatgtga atggccacaa gttcagcgtg agcggcgagg gcgagggcga tgccacctac      120

ggcaagctga ccctgaagtt catctgcacc accggcaagc tgcctgtgcc ctggcccacc      180

ctggtgacca ccctgagcta cggcgtgcag tgcttctcac gctaccccga tcacatgaag      240

cagcacgact tcttcaagag cgccatgcct gagggctaca tccaggagcg caccatcttc      300

ttcgaggatg acggcaacta caagtcgcgc gccgaggtga agttcgaggg cgataccctg      360

gtgaatcgca tcgagctgac cggcaccgat ttcaaggagg atggcaacat cctgggcaat      420

aagatggagt acaactacaa cgcccacaat gtgtacatca tgaccgacaa ggccaagaat      480

ggcatcaagg tgaacttcaa gatccgccac aacatcgagg atggcagcgt gcagctggcc      540

gaccactacc agcagaatac ccccatcggc gatggccctg tgctgctgcc cgataaccac      600

tacctgtcca cccagagcgc cctgtccaag gaccccaacg agaagcgcga tcacatgatc      660

tacttcggct tcgtgaccgc cgccgccatc acccacggca tggatgagct gtacaaggaa      720

ttctatccgt acgacgtacc agactacgca gaagaaacaa gagagctaca gtcgttagcg      780

gctgctgtgg tgccatctgc ccagaccctt aaaattactg actttagcct cagtgacttt      840

gagctgtctg atctggaaac agcactgtgt acaattcgga tgtttactga cctcaacctt      900

gtgcagaact tccggatgaa acatgaggtt ctttgcagat ggattttaag tgttaaggag      960

aattatcgga agaatgttgc ctatcataat tggagacatg cctttaatac agctcagtgc     1020

atgtttgccg ctctaaaagc aggcaaaatt cagaacaagc tgactgacct ggagatactt     1080

gcattgctga ttgctgcact aagccacgat ttggatcacc gtggtgtgaa taactcttac     1140

atacagcgaa gtgaacatcc acttgcccag ctttactgcc attcaatcat ggaacaccat     1200

cattttgacc agtgcctgat gattcttaat agtccaggca atcagattct cagtggcctc     1260

tccattgaag aatataagac cacgttgaaa ataatcaagc aagctatttt agctacaaac     1320

ctagcactgt acattaagag gcgaggagaa ttttttgaac ttataagaaa aaatcaattc     1380

aatttggaag atcctcatca aaaggagttg tttttggcaa tgctgatgac agcttgtgat     1440

ctttctgcaa ttacaaaacc ctggcctatt caacaacgga tagcggaact tgtagcaact     1500

gaattttttg atcaaggaga cagagagaga aaagaattca acatagaacc cacagatcta     1560

atgaacaggg agaagaaaaa caaaatccca agtatgcaag ttgggttcat agatgccatc     1620

tgcttgcaac tgtatgaggc cctgacccac gtgtcagagg actgtttccc tttgctagat     1680

ggctgcagaa agaacaggca gaaatggcag gcccttgcag aacagcagtg a              1731


<210> 59
<211> 576
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Destabilizing Domain (DD)"

<400> 59
Met Val Ser Lys Gly Ala Glu Leu Phe Thr Gly Ile Val Pro Ile Leu 
1               5                   10                  15      


Ile Glu Leu Asn Gly Asp Val Asn Gly His Lys Phe Ser Val Ser Gly 
            20                  25                  30          


Glu Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile 
        35                  40                  45              


Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr 
    50                  55                  60                  


Leu Ser Tyr Gly Val Gln Cys Phe Ser Arg Tyr Pro Asp His Met Lys 
65                  70                  75                  80  


Gln His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Ile Gln Glu 
                85                  90                  95      


Arg Thr Ile Phe Phe Glu Asp Asp Gly Asn Tyr Lys Ser Arg Ala Glu 
            100                 105                 110         


Val Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Thr Gly 
        115                 120                 125             


Thr Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly Asn Lys Met Glu Tyr 
    130                 135                 140                 


Asn Tyr Asn Ala His Asn Val Tyr Ile Met Thr Asp Lys Ala Lys Asn 
145                 150                 155                 160 


Gly Ile Lys Val Asn Phe Lys Ile Arg His Asn Ile Glu Asp Gly Ser 
                165                 170                 175     


Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly 
            180                 185                 190         


Pro Val Leu Leu Pro Asp Asn His Tyr Leu Ser Thr Gln Ser Ala Leu 
        195                 200                 205             


Ser Lys Asp Pro Asn Glu Lys Arg Asp His Met Ile Tyr Phe Gly Phe 
    210                 215                 220                 


Val Thr Ala Ala Ala Ile Thr His Gly Met Asp Glu Leu Tyr Lys Glu 
225                 230                 235                 240 


Phe Glu Glu Thr Arg Glu Leu Gln Ser Leu Ala Ala Ala Val Val Pro 
                245                 250                 255     


Ser Ala Gln Thr Leu Lys Ile Thr Asp Phe Ser Leu Ser Asp Phe Glu 
            260                 265                 270         


Leu Ser Asp Leu Glu Thr Ala Leu Cys Thr Ile Arg Met Phe Thr Asp 
        275                 280                 285             


Leu Asn Leu Val Gln Asn Phe Arg Met Lys His Glu Val Leu Cys Arg 
    290                 295                 300                 


Trp Ile Leu Ser Val Lys Glu Asn Tyr Arg Lys Asn Val Ala Tyr His 
305                 310                 315                 320 


Asn Trp Arg His Ala Phe Asn Thr Ala Gln Cys Met Phe Ala Ala Leu 
                325                 330                 335     


Lys Ala Gly Lys Ile Gln Asn Lys Leu Thr Asp Leu Glu Ile Leu Ala 
            340                 345                 350         


Leu Leu Ile Ala Ala Leu Ser His Asp Leu Asp His Arg Gly Val Asn 
        355                 360                 365             


Asn Ser Tyr Ile Gln Arg Ser Glu His Pro Leu Ala Gln Leu Tyr Cys 
    370                 375                 380                 


His Ser Ile Met Glu His His His Phe Asp Gln Cys Leu Met Ile Leu 
385                 390                 395                 400 


Asn Ser Pro Gly Asn Gln Ile Leu Ser Gly Leu Ser Ile Glu Glu Tyr 
                405                 410                 415     


Lys Thr Thr Leu Lys Ile Ile Lys Gln Ala Ile Leu Ala Thr Asn Leu 
            420                 425                 430         


Ala Leu Tyr Ile Lys Arg Arg Gly Glu Phe Phe Glu Leu Ile Arg Lys 
        435                 440                 445             


Asn Gln Phe Asn Leu Glu Asp Pro His Gln Lys Glu Leu Phe Leu Ala 
    450                 455                 460                 


Met Leu Met Thr Ala Cys Asp Leu Ser Ala Ile Thr Lys Pro Trp Pro 
465                 470                 475                 480 


Ile Gln Gln Arg Ile Ala Glu Leu Val Ala Thr Glu Phe Phe Asp Gln 
                485                 490                 495     


Gly Asp Arg Glu Arg Lys Glu Phe Asn Ile Glu Pro Thr Asp Leu Met 
            500                 505                 510         


Asn Arg Glu Lys Lys Asn Lys Ile Pro Ser Met Gln Val Gly Phe Ile 
        515                 520                 525             


Asp Ala Ile Cys Leu Gln Leu Tyr Glu Ala Leu Thr His Val Ser Glu 
    530                 535                 540                 


Asp Cys Phe Pro Leu Leu Asp Gly Cys Arg Lys Asn Arg Gln Lys Trp 
545                 550                 555                 560 


Gln Ala Leu Ala Glu Gln Gln Tyr Pro Tyr Asp Val Pro Asp Tyr Ala 
                565                 570                 575     


<210> 60
<211> 1731
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Destabilizing Domain (DD)"

<400> 60
atggtgagca agggcgccga gctgttcacc ggcatcgtgc ccatcctgat cgagctgaat       60

ggcgatgtga atggccacaa gttcagcgtg agcggcgagg gcgagggcga tgccacctac      120

ggcaagctga ccctgaagtt catctgcacc accggcaagc tgcctgtgcc ctggcccacc      180

ctggtgacca ccctgagcta cggcgtgcag tgcttctcac gctaccccga tcacatgaag      240

cagcacgact tcttcaagag cgccatgcct gagggctaca tccaggagcg caccatcttc      300

ttcgaggatg acggcaacta caagtcgcgc gccgaggtga agttcgaggg cgataccctg      360

gtgaatcgca tcgagctgac cggcaccgat ttcaaggagg atggcaacat cctgggcaat      420

aagatggagt acaactacaa cgcccacaat gtgtacatca tgaccgacaa ggccaagaat      480

ggcatcaagg tgaacttcaa gatccgccac aacatcgagg atggcagcgt gcagctggcc      540

gaccactacc agcagaatac ccccatcggc gatggccctg tgctgctgcc cgataaccac      600

tacctgtcca cccagagcgc cctgtccaag gaccccaacg agaagcgcga tcacatgatc      660

tacttcggct tcgtgaccgc cgccgccatc acccacggca tggatgagct gtacaaggaa      720

ttcgaagaaa caagagagct acagtcgtta gcggctgctg tggtgccatc tgcccagacc      780

cttaaaatta ctgactttag cctcagtgac tttgagctgt ctgatctgga aacagcactg      840

tgtacaattc ggatgtttac tgacctcaac cttgtgcaga acttccggat gaaacatgag      900

gttctttgca gatggatttt aagtgttaag gagaattatc ggaagaatgt tgcctatcat      960

aattggagac atgcctttaa tacagctcag tgcatgtttg ccgctctaaa agcaggcaaa     1020

attcagaaca agctgactga cctggagata cttgcattgc tgattgctgc actaagccac     1080

gatttggatc accgtggtgt gaataactct tacatacagc gaagtgaaca tccacttgcc     1140

cagctttact gccattcaat catggaacac catcattttg accagtgcct gatgattctt     1200

aatagtccag gcaatcagat tctcagtggc ctctccattg aagaatataa gaccacgttg     1260

aaaataatca agcaagctat tttagctaca aacctagcac tgtacattaa gaggcgagga     1320

gaattttttg aacttataag aaaaaatcaa ttcaatttgg aagatcctca tcaaaaggag     1380

ttgtttttgg caatgctgat gacagcttgt gatctttctg caattacaaa accctggcct     1440

attcaacaac ggatagcgga acttgtagca actgaatttt ttgatcaagg agacagagag     1500

agaaaagaat tcaacataga acccacagat ctaatgaaca gggagaagaa aaacaaaatc     1560

ccaagtatgc aagttgggtt catagatgcc atctgcttgc aactgtatga ggccctgacc     1620

cacgtgtcag aggactgttt ccctttgcta gatggctgca gaaagaacag gcagaaatgg     1680

caggcccttg cagaacagca gtatccgtac gacgtaccag actacgcatg a              1731


<210> 61
<211> 2502
<212> DNA
<213> Homo sapiens

<400> 61
atgttgccct ttggagacaa aacaagagaa atggtcaatg catggtttgc tgagagagtt       60

cacaccatcc ctgtgtgcaa ggaaggtatc agaggccaca ccgaatcttg ctcttgtccc      120

ttgcagcaga gtcctcgtgc agataacagt gcccctggaa caccaaccag gaaaatctct      180

gcctctgaat ttgaccggcc tcttagaccc attgttgtca aggattctga gggaactgtg      240

agcttcctct ctgactcaga aaagaaggaa cagatgcctc taacccctcc aaggtttgat      300

catgatgaag gggaccagtg ctcaagactc ttggaattag tgaaggatat ttctagtcat      360

ttggatgtca cagccttatg tcacaaaatt ttcttgcata tccatggact gatatctgct      420

gaccgctatt ccctgttcct tgtctgtgaa gacagctcca atgacaagtt tcttatcagc      480

cgcctctttg atgttgctga aggttcaaca ctggaagaag tttcaaataa ctgtatccgc      540

ttagaatgga acaaaggcat tgtgggacat gtggcagcgc ttggtgagcc cttgaacatc      600

aaagatgcat atgaggatcc tcggttcaat gcagaagttg accaaattac aggctacaag      660

acacaaagca ttctttgtat gccaattaag aatcataggg aagaggttgt tggtgtagcc      720

caggccatca acaagaaatc aggaaacggt gggacattta ctgaaaaaga tgaaaaggac      780

tttgctgctt atttggcatt ttgtggtatt gttcttcata atgctcagct ctatgagact      840

tcactgctgg agaacaagag aaatcaggtg ctgcttgacc ttgctagttt aatttttgaa      900

gaacaacaat cattagaagt aattttgaag aaaatagctg ccactattat ctctttcatg      960

caagtgcaga aatgcaccat tttcatagtg gatgaagatt gctccgattc tttttctagt     1020

gtgtttcaca tggagtgtga ggaattagaa aaatcatctg atacattaac aagggaacat     1080

gatgcaaaca aaatcaatta catgtatgct cagtatgtca aaaatactat ggaaccactt     1140

aatatcccag atgtcagtaa ggataaaaga tttccctgga caactgaaaa tacaggaaat     1200

gtaaaccagc agtgcattag aagtttgctt tgtacaccta taaaaaatgg aaagaagaat     1260

aaagttatag gggtttgcca acttgttaat aagatggagg agaatactgg caaggttaag     1320

cctttcaacc gaaatgacga acagtttctg gaagcttttg tcatcttttg tggcttgggg     1380

atccagaaca cgcagatgta tgaagcagtg gagagagcca tggccaagca aatggtcaca     1440

ttggaggttc tgtcgtatca tgcttcagca gcagaggaag aaacaagaga gctacagtcg     1500

ttagcggctg ctgtggtgcc atctgcccag acccttaaaa ttactgactt tagcttcagt     1560

gactttgagc tgtctgatct ggaaacagca ctgtgtacaa ttcggatgtt tactgacctc     1620

aaccttgtgc agaacttcca gatgaaacat gaggttcttt gcagatggat tttaagtgtt     1680

aagaagaatt atcggaagaa tgttgcctat cataattgga gacatgcctt taatacagct     1740

cagtgcatgt ttgctgctct aaaagcaggc aaaattcaga acaagctgac tgacctggag     1800

atacttgcat tgctgattgc tgcactaagc cacgatttgg atcaccgtgg tgtgaataac     1860

tcttacatac agcgaagtga acatccactt gcccagcttt actgccattc aatcatggaa     1920

caccatcatt ttgaccagtg cctgatgatt cttaatagtc caggcaatca gattctcagt     1980

ggcctctcca ttgaagaata taagaccacg ttgaaaataa tcaagcaagc tattttagct     2040

acagacctag cactgtacat taagaggcga ggagaatttt ttgaacttat aagaaaaaat     2100

caattcaatt tggaagatcc tcatcaaaag gagttgtttt tggcaatgct gatgacagct     2160

tgtgatcttt ctgcaattac aaaaccctgg cctattcaac aacggatagc agaacttgta     2220

gcaactgaat tttttgatca aggagacaga gagagaaaag aactcaacat agaacccact     2280

gatctaatga acagggagaa gaaaaacaaa atcccaagta tgcaagttgg gttcatagat     2340

gccatctgct tgcaactgta tgaggccctg acccacgtgt cagaggactg tttccctttg     2400

ctagatggct gcagaaagaa caggcagaaa tggcaggccc ttgcagaaca gcaggagaag     2460

atgctgatta atggggaaag cggccaggcc aagcggaact ga                        2502


<210> 62
<211> 2472
<212> DNA
<213> Homo sapiens

<400> 62
atggtcaatg catggtttgc tgagagagtt cacaccatcc ctgtgtgcaa ggaaggtatc       60

agaggccaca ccgaatcttg ctcttgtccc ttgcagcaga gtcctcgtgc agataacagt      120

gcccctggaa caccaaccag gaaaatctct gcctctgaat ttgaccggcc tcttagaccc      180

attgttgtca aggattctga gggaactgtg agcttcctct ctgactcaga aaagaaggaa      240

cagatgcctc taacccctcc aaggtttgat catgatgaag gggaccagtg ctcaagactc      300

ttggaattag tgaaggatat ttctagtcat ttggatgtca cagccttatg tcacaaaatt      360

ttcttgcata tccatggact gatatctgct gaccgctatt ccctgttcct tgtctgtgaa      420

gacagctcca atgacaagtt tcttatcagc cgcctctttg atgttgctga aggttcaaca      480

ctggaagaag tttcaaataa ctgtatccgc ttagaatgga acaaaggcat tgtgggacat      540

gtggcagcgc ttggtgagcc cttgaacatc aaagatgcat atgaggatcc tcggttcaat      600

gcagaagttg accaaattac aggctacaag acacaaagca ttctttgtat gccaattaag      660

aatcataggg aagaggttgt tggtgtagcc caggccatca acaagaaatc aggaaacggt      720

gggacattta ctgaaaaaga tgaaaaggac tttgctgctt atttggcatt ttgtggtatt      780

gttcttcata atgctcagct ctatgagact tcactgctgg agaacaagag aaatcaggtg      840

ctgcttgacc ttgctagttt aatttttgaa gaacaacaat cattagaagt aattttgaag      900

aaaatagctg ccactattat ctctttcatg caagtgcaga aatgcaccat tttcatagtg      960

gatgaagatt gctccgattc tttttctagt gtgtttcaca tggagtgtga ggaattagaa     1020

aaatcatctg atacattaac aagggaacat gatgcaaaca aaatcaatta catgtatgct     1080

cagtatgtca aaaatactat ggaaccactt aatatcccag atgtcagtaa ggataaaaga     1140

tttccctgga caactgaaaa tacaggaaat gtaaaccagc agtgcattag aagtttgctt     1200

tgtacaccta taaaaaatgg aaagaagaat aaagttatag gggtttgcca acttgttaat     1260

aagatggagg agaatactgg caaggttaag cctttcaacc gaaatgacga acagtttctg     1320

gaagcttttg tcatcttttg tggcttgggg atccagaaca cgcagatgta tgaagcagtg     1380

gagagagcca tggccaagca aatggtcaca ttggaggttc tgtcgtatca tgcttcagca     1440

gcagaggaag aaacaagaga gctacagtcg ttagcggctg ctgtggtgcc atctgcccag     1500

acccttaaaa ttactgactt tagcttcagt gactttgagc tgtctgatct ggaaacagca     1560

ctgtgtacaa ttcggatgtt tactgacctc aaccttgtgc agaacttcca gatgaaacat     1620

gaggttcttt gcagatggat tttaagtgtt aagaagaatt atcggaagaa tgttgcctat     1680

cataattgga gacatgcctt taatacagct cagtgcatgt ttgctgctct aaaagcaggc     1740

aaaattcaga acaagctgac tgacctggag atacttgcat tgctgattgc tgcactaagc     1800

cacgatttgg atcaccgtgg tgtgaataac tcttacatac agcgaagtga acatccactt     1860

gcccagcttt actgccattc aatcatggaa caccatcatt ttgaccagtg cctgatgatt     1920

cttaatagtc caggcaatca gattctcagt ggcctctcca ttgaagaata taagaccacg     1980

ttgaaaataa tcaagcaagc tattttagct acagacctag cactgtacat taagaggcga     2040

ggagaatttt ttgaacttat aagaaaaaat caattcaatt tggaagatcc tcatcaaaag     2100

gagttgtttt tggcaatgct gatgacagct tgtgatcttt ctgcaattac aaaaccctgg     2160

cctattcaac aacggatagc agaacttgta gcaactgaat tttttgatca aggagacaga     2220

gagagaaaag aactcaacat agaacccact gatctaatga acagggagaa gaaaaacaaa     2280

atcccaagta tgcaagttgg gttcatagat gccatctgct tgcaactgta tgaggccctg     2340

acccacgtgt cagaggactg tttccctttg ctagatggct gcagaaagaa caggcagaaa     2400

tggcaggccc ttgcagaaca gcaggagaag atgctgatta atggggaaag cggccaggcc     2460

aagcggaact ga                                                         2472


<210> 63
<211> 1023
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Destabilizing Domain (DD)"

<400> 63
gaagaaacaa gagagctaca gtcgttagcg gctgctgtgg tgccatctgc ccagaccctt       60

aaaattactg actttagctt cagtgacttt gagctgtctg atctggaaac agcactgtgt      120

acaattcgga tgtttactga cctcaacctt gtgcagaact tccggatgaa acatgaggtt      180

ctttgcagat ggattttaag tgttaagaag aattatcgga agaatgttgc ctatcataat      240

tggagacatg cctttaatac agctcagtgc atgtttgccg ctctaaaagc aggcaaaatt      300

cagaacaagc tgactgacct ggagatactt gcattgctga ttgctgcact aagccacgat      360

ttggatcacc gtggtgtgaa taactcttac atacagcgaa gtgaacatcc acttgcccag      420

ctttactgcc attcaatcat ggaacaccat cattttgacc agtgcctgat gattcttaat      480

agtccaggca atcagattct cagtggcctc tccattgaag aatataagac cacgttgaaa      540

ataatcaagc aagctatttt agctacagac ctagcactgt acattaagag gcgaggagaa      600

ttttttgaac ttataagaaa aaatcaattc aatttggaag atcctcatca aaaggagttg      660

tttttggcaa tgctgatgac agcttgtgat ctttctgcaa ttacaaaacc ctggcctatt      720

caacaacgga tagcggaact tgtagcaact gaattttttg atcaaggaga cagagagaga      780

aaagaactca acatagaacc cactgatcta atgaacaggg agaagaaaaa caaaatccca      840

agtatgcaag ttgggttcat agatgccatc tgcttgcaac tgtatgaggc cctgacccac      900

gtgtcagagg actgtttccc tttgctagat ggctgcagaa agaacaggca gaaatggcag      960

gcccttgcag aacagcagga gaagatgctg attaatgggg aaagcggcca ggccaagcgg     1020

aac                                                                   1023


<210> 64
<211> 1230
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Destabilizing Domain (DD)"

<400> 64
ggggtttgcc aacttgttaa taagatggag gagaatactg gcaaggttaa gcctttcaac       60

cgaaatgacg aacagtttct ggaagctttt gtcatctttt gtggcttggg gatccagaac      120

acgcagatgt atgaagcagt ggagagagcc atggccaagc aaatggtcac attggaggtt      180

ctgtcgtatc atgcttcagc agcagaggaa gaaacaagag agctacagtc gttagcggct      240

gctgtggtgc catctgccca gacccttaaa attactgact ttagcttcag tgactttgag      300

ctgtctgatc tggaaacagc actgtgtaca attcggatgt ttactgacct caaccttgtg      360

cagaacttcc ggatgaaaca tgaggttctt tgcagatgga ttttaagtgt taagaagaat      420

tatcggaaga atgttgccta tcataattgg agacatgcct ttaatacagc tcagtgcatg      480

tttgccgctc taaaagcagg caaaattcag aacaagctga ctgacctgga gatacttgca      540

ttgctgattg ctgcactaag ccacgatttg gatcaccgtg gtgtgaataa ctcttacata      600

cagcgaagtg aacatccact tgcccagctt tactgccatt caatcatgga acaccatcat      660

tttgaccagt gcctgatgat tcttaatagt ccaggcaatc agattctcag tggcctctcc      720

attgaagaat ataagaccac gttgaaaata atcaagcaag ctattttagc tacagaccta      780

gcactgtaca ttaagaggcg aggagaattt tttgaactta taagaaaaaa tcaattcaat      840

ttggaagatc ctcatcaaaa ggagttgttt ttggcaatgc tgatgacagc ttgtgatctt      900

tctgcaatta caaaaccctg gcctattcaa caacggatag cggaacttgt agcaactgaa      960

ttttttgatc aaggagacag agagagaaaa gaactcaaca tagaacccac tgatctaatg     1020

aacagggaga agaaaaacaa aatcccaagt atgcaagttg ggttcataga tgccatctgc     1080

ttgcaactgt atgaggccct gacccacgtg tcagaggact gtttcccttt gctagatggc     1140

tgcagaaaga acaggcagaa atggcaggcc cttgcagaac agcaggagaa gatgctgatt     1200

aatggggaaa gcggccaggc caagcggaac                                      1230


<210> 65
<211> 1368
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Destabilizing Domain (DD)"

<400> 65
gaaccactta atatcccaga tgtcagtaag gataaaagat ttccctggac aactgaaaat       60

acaggaaatg taaaccagca gtgcattaga agtttgcttt gtacacctat aaaaaatgga      120

aagaagaata aagttatagg ggtttgccaa cttgttaata agatggagga gaatactggc      180

aaggttaagc ctttcaaccg aaatgacgaa cagtttctgg aagcttttgt catcttttgt      240

ggcttgggga tccagaacac gcagatgtat gaagcagtgg agagagccat ggccaagcaa      300

atggtcacat tggaggttct gtcgtatcat gcttcagcag cagaggaaga aacaagagag      360

ctacagtcgt tagcggctgc tgtggtgcca tctgcccaga cccttaaaat tactgacttt      420

agcttcagtg actttgagct gtctgatctg gaaacagcac tgtgtacaat tcggatgttt      480

actgacctca accttgtgca gaacttccgg atgaaacatg aggttctttg cagatggatt      540

ttaagtgtta agaagaatta tcggaagaat gttgcctatc ataattggag acatgccttt      600

aatacagctc agtgcatgtt tgccgctcta aaagcaggca aaattcagaa caagctgact      660

gacctggaga tacttgcatt gctgattgct gcactaagcc acgatttgga tcaccgtggt      720

gtgaataact cttacataca gcgaagtgaa catccacttg cccagcttta ctgccattca      780

atcatggaac accatcattt tgaccagtgc ctgatgattc ttaatagtcc aggcaatcag      840

attctcagtg gcctctccat tgaagaatat aagaccacgt tgaaaataat caagcaagct      900

attttagcta cagacctagc actgtacatt aagaggcgag gagaattttt tgaacttata      960

agaaaaaatc aattcaattt ggaagatcct catcaaaagg agttgttttt ggcaatgctg     1020

atgacagctt gtgatctttc tgcaattaca aaaccctggc ctattcaaca acggatagcg     1080

gaacttgtag caactgaatt ttttgatcaa ggagacagag agagaaaaga actcaacata     1140

gaacccactg atctaatgaa cagggagaag aaaaacaaaa tcccaagtat gcaagttggg     1200

ttcatagatg ccatctgctt gcaactgtat gaggccctga cccacgtgtc agaggactgt     1260

ttccctttgc tagatggctg cagaaagaac aggcagaaat ggcaggccct tgcagaacag     1320

caggagaaga tgctgattaa tggggaaagc ggccaggcca agcggaac                  1368


<210> 66
<211> 326
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Destabilizing Domain (DD)"

<400> 66
Glu Glu Thr Arg Glu Leu Gln Ser Leu Ala Ala Ala Val Val Pro Ser 
1               5                   10                  15      


Ala Gln Thr Leu Lys Ile Thr Asp Phe Ser Phe Ser Asp Phe Glu Leu 
            20                  25                  30          


Ser Asp Leu Glu Thr Ala Leu Cys Thr Ile Arg Met Phe Thr Asp Leu 
        35                  40                  45              


Asn Leu Val Gln Asn Phe Arg Met Lys His Glu Val Leu Cys Arg Trp 
    50                  55                  60                  


Ile Leu Ser Val Lys Lys Asn Tyr Arg Lys Asn Val Ala Tyr His Asn 
65                  70                  75                  80  


Trp Arg His Ala Phe Asn Thr Ala Gln Cys Met Phe Ala Ala Leu Lys 
                85                  90                  95      


Ala Gly Glu Ile Gln Asn Lys Leu Thr Asp Leu Glu Ile Leu Ala Leu 
            100                 105                 110         


Leu Ile Ala Ala Leu Ser His Asp Leu Asp His Arg Gly Val Asn Asn 
        115                 120                 125             


Ser Tyr Ile Gln Arg Ser Glu His Pro Leu Ala Gln Leu Tyr Cys His 
    130                 135                 140                 


Ser Ile Met Glu His His His Phe Asp Gln Cys Leu Met Ile Leu Asn 
145                 150                 155                 160 


Ser Pro Gly Asn Gln Ile Leu Ser Gly Leu Ser Ile Glu Glu Tyr Lys 
                165                 170                 175     


Thr Ser Leu Lys Ile Ile Lys Gln Ala Ile Leu Ala Thr Asp Leu Ala 
            180                 185                 190         


Leu Tyr Ile Lys Arg Arg Gly Glu Phe Phe Glu Leu Ile Arg Lys Asn 
        195                 200                 205             


Gln Phe Asn Leu Glu Asp Pro His Gln Lys Glu Leu Phe Leu Ala Met 
    210                 215                 220                 


Leu Met Thr Ala Cys Asp Leu Ser Ala Ile Thr Lys Pro Trp Pro Ile 
225                 230                 235                 240 


Gln Gln Arg Ile Ala Glu Leu Val Ala Thr Glu Phe Phe Asp Gln Gly 
                245                 250                 255     


Asp Arg Glu Arg Glu Glu Leu Asn Ile Glu Pro Thr Asp Leu Met Asn 
            260                 265                 270         


Arg Glu Lys Lys Asn Lys Ile Pro Ser Met Gln Val Gly Phe Ile Asp 
        275                 280                 285             


Ala Ile Cys Leu Gln Leu Tyr Glu Ala Leu Thr His Val Ser Glu Asp 
    290                 295                 300                 


Cys Phe Pro Leu Leu Asp Gly Cys Arg Lys Asn Arg Gln Glu Trp Gln 
305                 310                 315                 320 


Ala Leu Ala Glu Gln Gln 
                325     


<210> 67
<211> 326
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Destabilizing Domain (DD)"

<400> 67
Glu Gly Thr Arg Glu Leu Gln Ser Leu Ala Ala Ala Val Val Pro Ser 
1               5                   10                  15      


Ala Gln Thr Leu Lys Ile Thr Asp Phe Ser Phe Ser Asp Phe Glu Leu 
            20                  25                  30          


Ser Asp Leu Glu Thr Ala Leu Cys Thr Ile Arg Met Phe Thr Asp Leu 
        35                  40                  45              


Asn Leu Val Gln Asn Phe Arg Met Lys His Glu Val Leu Cys Arg Trp 
    50                  55                  60                  


Ile Leu Ser Val Lys Lys Asn Tyr Arg Lys Asn Val Ala Tyr His Asn 
65                  70                  75                  80  


Trp Arg His Ala Phe Asn Thr Ala Gln Cys Met Phe Ala Ala Leu Lys 
                85                  90                  95      


Ala Gly Lys Ile Gln Asn Lys Leu Thr Asp Leu Glu Ile Leu Ala Leu 
            100                 105                 110         


Leu Ile Ala Ala Leu Ser His Asp Leu Asp His Arg Gly Val Asn Asn 
        115                 120                 125             


Ser Tyr Ile Gln Arg Ser Glu His Pro Leu Ala Gln Leu Tyr Cys His 
    130                 135                 140                 


Ser Ile Met Glu His His His Phe Asp Gln Cys Leu Met Ile Leu Asn 
145                 150                 155                 160 


Ser Pro Gly Asn Gln Ile Leu Ser Gly Leu Ser Ile Glu Glu Tyr Lys 
                165                 170                 175     


Thr Thr Leu Lys Ile Ile Lys Gln Ala Ile Leu Ala Thr Asp Leu Ala 
            180                 185                 190         


Leu Tyr Ile Lys Arg Arg Gly Glu Phe Phe Glu Leu Ile Arg Lys Asn 
        195                 200                 205             


Gln Phe Asn Leu Glu Asp Pro His Gln Lys Glu Leu Phe Leu Ala Met 
    210                 215                 220                 


Leu Met Thr Ala Cys Asp Leu Ser Ala Ile Thr Lys Pro Trp Pro Ile 
225                 230                 235                 240 


Gln Gln Arg Ile Ala Glu Leu Val Ala Thr Glu Phe Phe Asp Gln Gly 
                245                 250                 255     


Asp Arg Glu Arg Lys Glu Leu Asn Ile Glu Pro Thr Asp Leu Met Asn 
            260                 265                 270         


Arg Glu Lys Lys Asn Lys Ile Pro Ser Met Gln Val Gly Phe Ile Asp 
        275                 280                 285             


Ala Ile Cys Leu Gln Leu Tyr Glu Ala Leu Thr His Val Ser Glu Asp 
    290                 295                 300                 


Ser Phe Pro Leu Leu Asp Gly Cys Arg Lys Asn Arg Gln Lys Trp Gln 
305                 310                 315                 320 


Ala Leu Ala Glu Gln Gln 
                325     


<210> 68
<211> 326
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Destabilizing Domain (DD)"

<400> 68
Glu Glu Thr Arg Glu Leu Gln Ser Leu Ala Ala Ala Val Val Pro Ser 
1               5                   10                  15      


Ala Gln Thr Leu Lys Ile Thr Asp Phe Ser Phe Ser Asp Phe Glu Leu 
            20                  25                  30          


Ser Asp Leu Glu Thr Ala Leu Cys Thr Ile Arg Met Phe Thr Asp Leu 
        35                  40                  45              


Asn Leu Val Gln Ser Phe Arg Met Lys His Glu Val Leu Cys Arg Trp 
    50                  55                  60                  


Ile Leu Ser Val Lys Lys Asn Tyr Arg Glu Asn Val Ala Tyr His Asn 
65                  70                  75                  80  


Trp Arg His Ala Phe Asn Thr Ala Gln Cys Met Phe Ala Ala Leu Lys 
                85                  90                  95      


Ala Gly Lys Ile Gln Asn Lys Leu Thr Asp Leu Glu Ile Leu Ala Leu 
            100                 105                 110         


Leu Ile Ala Ala Leu Ser His Asp Leu Asp His Arg Gly Val Ser Asn 
        115                 120                 125             


Ser Tyr Ile Gln Arg Ser Glu His Pro Leu Ala Gln Leu Tyr Cys His 
    130                 135                 140                 


Ser Ile Met Glu His His His Phe Asp Gln Cys Leu Met Ile Leu Asn 
145                 150                 155                 160 


Ser Pro Gly Asn Gln Ile Leu Ser Gly Leu Ser Ile Glu Glu Tyr Lys 
                165                 170                 175     


Thr Thr Leu Lys Ile Ile Lys Gln Ala Ile Leu Ala Thr Asp Leu Ala 
            180                 185                 190         


Leu Tyr Ile Lys Arg Arg Gly Glu Phe Phe Glu Leu Ile Arg Lys Asn 
        195                 200                 205             


Gln Phe Asn Leu Glu Asp Pro His Gln Lys Glu Leu Phe Leu Ala Met 
    210                 215                 220                 


Leu Met Thr Ala Cys Val Leu Ser Ala Ile Thr Lys Pro Trp Pro Ile 
225                 230                 235                 240 


Gln Gln Arg Ile Ala Glu Leu Val Ala Thr Glu Phe Phe Asp Gln Gly 
                245                 250                 255     


Asp Arg Glu Arg Lys Glu Leu Asn Ile Glu Pro Thr Asp Leu Met Asn 
            260                 265                 270         


Arg Glu Lys Lys Asn Lys Ile Pro Ser Met Gln Val Gly Phe Ile Asp 
        275                 280                 285             


Ala Ile Cys Leu Gln Leu Tyr Glu Ala Leu Thr His Val Ser Glu Asp 
    290                 295                 300                 


Cys Phe Pro Leu Leu Asp Gly Cys Arg Lys Asn Arg Gln Lys Trp Gln 
305                 310                 315                 320 


Ala Leu Ala Glu Gln Gln 
                325     


<210> 69
<211> 326
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Destabilizing Domain (DD)"

<400> 69
Glu Glu Thr Arg Glu Leu Gln Ser Leu Ala Ala Ala Val Val Pro Ser 
1               5                   10                  15      


Ala Gln Thr Leu Lys Ile Thr Asp Phe Ser Phe Ser Asp Phe Glu Leu 
            20                  25                  30          


Ser Asp Leu Glu Thr Ala Leu Cys Thr Ile Arg Met Phe Thr Asp Leu 
        35                  40                  45              


Asn Leu Val Gln Asn Phe Arg Met Lys His Glu Val Leu Cys Arg Trp 
    50                  55                  60                  


Ile Leu Ser Val Lys Lys Asn Tyr Arg Lys Asn Val Ala Tyr His Asn 
65                  70                  75                  80  


Trp Arg His Ala Phe Asn Thr Ala Gln Cys Met Phe Ala Ala Leu Lys 
                85                  90                  95      


Ala Gly Lys Ile Gln Asn Lys Leu Thr Asp Leu Glu Ile Leu Ala Leu 
            100                 105                 110         


Leu Ile Ala Ala Leu Ser His Asp Leu Asp His Arg Gly Val Asn Asn 
        115                 120                 125             


Ser Tyr Ile Gln Arg Ser Glu His Pro Leu Ala Gln Pro Tyr Cys His 
    130                 135                 140                 


Ser Ile Met Glu His His His Phe Asp Gln Cys Leu Met Ile Leu Asn 
145                 150                 155                 160 


Ser Pro Gly Asn Gln Ile Leu Ser Gly Leu Ser Ile Glu Glu Tyr Lys 
                165                 170                 175     


Thr Thr Leu Lys Ile Ile Lys Gln Ala Ile Leu Ala Thr Asp Leu Ala 
            180                 185                 190         


Leu Tyr Ile Lys Arg Arg Gly Glu Phe Phe Glu Leu Ile Arg Lys Asn 
        195                 200                 205             


Gln Phe Asn Leu Glu Asp Pro His Gln Lys Glu Leu Leu Leu Ala Met 
    210                 215                 220                 


Leu Met Thr Ala Cys Asp Leu Ser Ala Ile Thr Lys Pro Trp Pro Ile 
225                 230                 235                 240 


Gln Gln Arg Ile Ala Glu Leu Val Ala Thr Glu Phe Phe Asp Gln Gly 
                245                 250                 255     


Asp Arg Glu Arg Lys Glu Leu Asn Ile Glu Pro Thr Asp Leu Met Asn 
            260                 265                 270         


Arg Glu Lys Lys Asn Lys Ile Pro Ser Met Gln Val Gly Phe Ile Asp 
        275                 280                 285             


Ala Ile Cys Leu Gln Leu Tyr Glu Ala Leu Thr His Val Ser Glu Asp 
    290                 295                 300                 


Cys Phe Pro Leu Leu Asp Gly Cys Arg Lys Asn Arg Gln Lys Trp Gln 
305                 310                 315                 320 


Ala Leu Ala Glu Gln Gln 
                325     


<210> 70
<211> 978
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Destabilizing Domain (DD)"

<400> 70
gaagaaacaa gagagctaca gtcgttagcg gctgctgtgg tgccatctgc ccagaccctt       60

aaaattactg actttagctt cagtgacttt gagctgtctg atctggaaac agcactgtgt      120

acaattcgga tgtttactga cctcaacctt gtgcagaact tccggatgaa acatgaggtt      180

ctttgcagat ggattttaag tgttaagaag aattatcgga agaatgttgc ctatcataat      240

tggagacatg cctttaatac agctcagtgc atgtttgccg ctctaaaagc aggcgaaatt      300

cagaacaagc tgactgacct ggagatactt gcattgctga ttgctgcact aagccacgat      360

ttggatcacc gtggtgtgaa taactcttac atacagcgaa gtgaacaccc acttgcccag      420

ctttactgcc attcaatcat ggaacaccat cattttgacc agtgcctgat gattcttaat      480

agtccaggca atcagattct cagtggcctc tccattgaag aatataagac ctcgttgaaa      540

ataatcaagc aagctatttt agctacagac ctagcactgt acattaagag gcgaggagaa      600

ttttttgaac ttataagaaa aaatcaattc aatttggaag atcctcatca aaaggagttg      660

tttttggcaa tgctgatgac agcttgtgat ctttctgcaa ttacaaaacc ctggccaatt      720

caacaacgga tagcggaact tgtagcaact gaattttttg atcaaggaga cagagagaga      780

gaagaactca acatagaacc cactgatcta atgaacaggg agaagaaaaa caaaatccca      840

agtatgcaag ttgggttcat agatgccatc tgcttgcaac tgtatgaggc cctgacccac      900

gtgtcagagg actgtttccc tttgctagat ggctgcagaa agaacaggca ggaatggcag      960

gcccttgcag aacagcag                                                    978


<210> 71
<211> 978
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Destabilizing Domain (DD)"

<400> 71
gaaggaacaa gagagctaca gtcgttagcg gctgctgtgg tgccatctgc ccagaccctt       60

aaaattactg actttagctt cagtgacttt gagctgtctg atctggaaac agcactgtgt      120

acaattcgga tgtttactga cctcaacctt gtgcagaact tccggatgaa acatgaggtt      180

ctttgcagat ggattttaag tgttaagaag aattatcgga agaatgttgc ctatcataat      240

tggagacatg cctttaatac agctcagtgc atgtttgccg ctctaaaagc aggcaaaatt      300

cagaacaagc tgactgacct ggagatactt gcattgctga ttgctgcact aagccacgat      360

ttggatcacc gtggtgtgaa taactcttac atacagcgaa gtgaacatcc acttgcccag      420

ctttactgcc attctatcat ggaacaccat cattttgacc agtgcctgat gattcttaat      480

agtccaggca atcagattct cagtggcctc tccattgaag aatataagac cacgttgaaa      540

ataatcaagc aagctatttt agcaacagac ctagcactgt acattaagag gcgaggagaa      600

ttttttgaac ttataagaaa aaatcaattc aatttggaag atcctcatca aaaggagttg      660

tttttggcaa tgctgatgac agcttgtgat ctttctgcaa ttacaaaacc ctggcctatt      720

caacaacgga tagcggaact tgtagcaact gaattttttg atcaaggaga cagagagaga      780

aaagaactca acatagaacc cactgatcta atgaacaggg agaagaaaaa caaaatccca      840

agtatgcaag ttgggttcat agacgccatc tgcttgcaac tgtatgaggc cctgacccac      900

gtgtcagagg acagtttccc tttgctagat ggctgcagaa agaacaggca gaaatggcag      960

gcccttgcag aacagcag                                                    978


<210> 72
<211> 978
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Destabilizing Domain (DD)"

<400> 72
gaagaaacaa gagagctaca gtcgttagcg gctgctgtgg tgccatctgc ccagaccctt       60

aaaattactg actttagctt cagtgacttt gagctgtctg atctggaaac agcactgtgt      120

acaattcgga tgtttactga cctcaacctt gtgcagagct tccggatgaa acatgaggtt      180

ctttgcagat ggattttaag tgttaagaag aattatcggg agaatgttgc ctatcataat      240

tggagacatg cctttaatac agctcagtgc atgtttgccg ctctaaaagc aggcaaaatt      300

cagaacaagc tgactgacct ggagatactt gcattgctga ttgctgcact aagccacgat      360

ttggatcacc gtggtgtgag taactcttac atacagcgaa gtgaacatcc acttgcccag      420

ctttactgcc attcaatcat ggaacaccat cattttgacc agtgcctgat gattcttaat      480

agtccaggca atcagattct cagtggcctc tccattgaag aatataagac cacgttgaaa      540

ataatcaagc aagctatttt agctacagac ctagcactgt acattaagag gcgaggagaa      600

ttttttgaac ttataagaaa aaatcaattc aatttggaag atcctcatca aaaggagttg      660

tttttggcaa tgctgatgac agcttgtgtt ctttctgcaa ttacaaaacc ctggcctatt      720

caacaacgga tagcggaact tgtagcaact gaattttttg atcaaggaga cagagagaga      780

aaagaactca acatagaacc cactgatcta atgaacaggg agaagaaaaa caaaatccca      840

agtatgcaag ttgggttcat agatgccatc tgcttgcaac tgtatgaggc cctgacccac      900

gtgtcagagg actgtttccc tttgctagat ggctgcagaa agaacaggca gaaatggcag      960

gcccttgcag aacagcag                                                    978


<210> 73
<211> 978
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Destabilizing Domain (DD)"

<400> 73
gaagaaacaa gagagctaca gtcgttagcg gctgctgtgg tgccatctgc ccagaccctt       60

aaaattactg actttagctt cagtgacttt gagctgtctg atctggaaac agcactgtgt      120

acaattcgga tgtttactga cctcaacctt gtgcagaact tccggatgaa acatgaggtt      180

ctttgcagat ggattttaag tgttaagaag aattatcgga agaatgttgc ctatcataat      240

tggagacatg cctttaatac agctcagtgc atgtttgccg ctctaaaagc aggcaaaatt      300

cagaacaagc tgactgacct ggagatactt gcattgctga ttgctgcact aagccacgat      360

ttggatcacc gtggtgtgaa taactcttac atacagcgaa gtgaacatcc acttgcccag      420

ccttactgcc attcaatcat ggaacaccat cattttgacc agtgcctgat gattcttaat      480

agtccaggca atcagattct cagtggcctc tccattgaag aatataagac cacgttgaaa      540

ataatcaagc aagctatttt agctacagac ctagcactgt acattaagag gcgaggagaa      600

ttttttgaac ttataagaaa aaatcaattc aatttggaag atcctcatca aaaggagttg      660

ttgttggcaa tgctgatgac agcttgtgat ctttctgcaa ttacaaaacc ctggcctatt      720

caacaacgga tagcggaact cgtagcaact gaattttttg atcaaggaga cagagagaga      780

aaagaactca acatagaacc cactgatcta atgaacaggg agaagaaaaa caaaatccca      840

agtatgcaag ttgggttcat agatgccatc tgcttgcaac tgtatgaggc cctgacccac      900

gtgtcagagg actgtttccc tttgctagat ggctgcagaa agaacaggca gaaatggcag      960

gcccttgcag aacagcag                                                    978


<210> 74
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Tag"

<400> 74
Tyr Pro Tyr Asp Val Pro Asp Tyr Ala 
1               5                   


<210> 75
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Tag"

<400> 75
tatccgtacg acgtaccaga ctacgca                                           27


<210> 76
<211> 239
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      POI sequence"

<400> 76
Met Val Ser Lys Gly Ala Glu Leu Phe Thr Gly Ile Val Pro Ile Leu 
1               5                   10                  15      


Ile Glu Leu Asn Gly Asp Val Asn Gly His Lys Phe Ser Val Ser Gly 
            20                  25                  30          


Glu Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile 
        35                  40                  45              


Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr 
    50                  55                  60                  


Leu Ser Tyr Gly Val Gln Cys Phe Ser Arg Tyr Pro Asp His Met Lys 
65                  70                  75                  80  


Gln His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Ile Gln Glu 
                85                  90                  95      


Arg Thr Ile Phe Phe Glu Asp Asp Gly Asn Tyr Lys Ser Arg Ala Glu 
            100                 105                 110         


Val Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Thr Gly 
        115                 120                 125             


Thr Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly Asn Lys Met Glu Tyr 
    130                 135                 140                 


Asn Tyr Asn Ala His Asn Val Tyr Ile Met Thr Asp Lys Ala Lys Asn 
145                 150                 155                 160 


Gly Ile Lys Val Asn Phe Lys Ile Arg His Asn Ile Glu Asp Gly Ser 
                165                 170                 175     


Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly 
            180                 185                 190         


Pro Val Leu Leu Pro Asp Asn His Tyr Leu Ser Thr Gln Ser Ala Leu 
        195                 200                 205             


Ser Lys Asp Pro Asn Glu Lys Arg Asp His Met Ile Tyr Phe Gly Phe 
    210                 215                 220                 


Val Thr Ala Ala Ala Ile Thr His Gly Met Asp Glu Leu Tyr Lys 
225                 230                 235                 


<210> 77
<211> 717
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      POI sequence"

<400> 77
atggtgagca agggcgccga gctgttcacc ggcatcgtgc ccatcctgat cgagctgaat       60

ggcgatgtga atggccacaa gttcagcgtg agcggcgagg gcgagggcga tgccacctac      120

ggcaagctga ccctgaagtt catctgcacc accggcaagc tgcctgtgcc ctggcccacc      180

ctggtgacca ccctgagcta cggcgtgcag tgcttctcac gctaccccga tcacatgaag      240

cagcacgact tcttcaagag cgccatgcct gagggctaca tccaggagcg caccatcttc      300

ttcgaggatg acggcaacta caagtcgcgc gccgaggtga agttcgaggg cgataccctg      360

gtgaatcgca tcgagctgac cggcaccgat ttcaaggagg atggcaacat cctgggcaat      420

aagatggagt acaactacaa cgcccacaat gtgtacatca tgaccgacaa ggccaagaat      480

ggcatcaagg tgaacttcaa gatccgccac aacatcgagg atggcagcgt gcagctggcc      540

gaccactacc agcagaatac ccccatcggc gatggccctg tgctgctgcc cgataaccac      600

tacctgtcca cccagagcgc cctgtccaag gaccccaacg agaagcgcga tcacatgatc      660

tacttcggct tcgtgaccgc cgccgccatc acccacggca tggatgagct gtacaag         717


