                               SEQUENCE LISTING

<110> TENEOBIO, INC.
 
<120> ANTI-BCMA HEAVY CHAIN-ONLY ANTIBODIES

<130> TNO-0004-WO

<140> PCT/US2018/038549
<141> 2018-06-20

<150> 62/522,355
<151> 2017-06-20

<160> 21    

<170> PatentIn version 3.5

<210> 1
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 1
Gly Phe Thr Phe Thr Asn His Ala 
1               5               


<210> 2
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 2
Gly Phe Thr Phe Ser Ser His Ala 
1               5               


<210> 3
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 3
Gly Phe Thr Phe Ser Ser Tyr Ala 
1               5               


<210> 4
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 4
Ile Ser Gly Asn Gly Arg Thr Thr 
1               5               


<210> 5
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 5
Ile Ser Gly Ser Gly Asp Phe Thr 
1               5               


<210> 6
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 6
Ile Ser Gly Ser Gly Asp Tyr Thr 
1               5               


<210> 7
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 7
Ile Ser Gly Ser Gly Asp Tyr Ile 
1               5               


<210> 8
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 8
Ala Lys Asp Gly Gly Glu Thr Leu Val Asp Ser 
1               5                   10      


<210> 9
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 9
Ala Lys Asp Glu Asp Gly Gly Ser Leu Leu Gly Tyr 
1               5                   10          


<210> 10
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 10
Ala Lys Asp Glu Asp Gly Gly Ser Leu Leu Gly His 
1               5                   10          


<210> 11
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 11
Ala Lys Glu Gly Thr Gly Ala Asn Ser Ser Leu Ala Asp Tyr 
1               5                   10                  


<210> 12
<211> 118
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 12
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Thr Asn His 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Leu Val 
        35                  40                  45              


Ser Ser Ile Ser Gly Asn Gly Arg Thr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Ile Ser Lys Asn Thr Leu Asp 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Asp Gly Gly Glu Thr Leu Val Asp Ser Arg Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210> 13
<211> 119
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 13
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser His 
            20                  25                  30          


Ala Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Ala Ile Ser Gly Ser Gly Asp Phe Thr His Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Ser 
65                  70                  75                  80  


Leu Gln Met Asn Asn Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Asp Glu Asp Gly Gly Ser Leu Leu Gly Tyr Arg Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210> 14
<211> 119
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 14
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Ile Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser His 
            20                  25                  30          


Ala Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Asp Tyr Thr His Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Asp Glu Asp Gly Gly Ser Leu Leu Gly His Arg Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210> 15
<211> 121
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 15
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Ser Gly Ser Gly Asp Tyr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Ile Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Glu Gly Thr Gly Ala Asn Ser Ser Leu Ala Asp Tyr Arg Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210> 16
<211> 354
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 16
caggtgcagc tggtggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttacc aaccatgcca tgagttgggt ccgccaggct      120

ccagggaagg ggctggagtt ggtctcaagt attagtggta atggtcgtac cacatactac      180

gcagactccg tgaagggccg gttcaccatc tccagagaca tttccaagaa cacgctggat      240

ctgcaaatga acagcctgag agccgaggac acggccgtat attactgtgc gaaagatggg      300

ggcgaaactc tagttgactc cagaggccag ggcaccctgg tcaccgtctc ctca            354


<210> 17
<211> 357
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 17
caggtgcagc tggtggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttagc agccatgcca tgacctgggt ccgccaggct      120

ccggggaagg ggctggagtg ggtcgcagct attagtggca gtggtgattt cacacactac      180

gcagactccg tgaagggccg gttcaccatc tccagagaca attccaagaa cacggtgtct      240

ctgcaaatga acaacctgag agccgaggac acggccgtat attactgtgc gaaagatgag      300

gatggtggga gcttgcttgg ctacagaggc cagggcaccc tggtcaccgt ctcctca         357


<210> 18
<211> 357
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 18
gaggtgcagc tgttggagtc tggggggggc ttgatacagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttagc agccatgcca tgacctgggt ccgccaggct      120

ccggggaagg ggctggagtg ggtctcagct attagtggta gtggtgatta cacacactac      180

gcagactccg tgaagggtcg gttcaccatc tccagagaca attccaagaa cacggtgtat      240

ctccaaatga acagtctgag agccgaggac tcggccgtat attactgtgc gaaagatgag      300

gatggtggga gcctcctggg gcacagaggc cagggcaccc tggtcaccgt ctcctca         357


<210> 19
<211> 363
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 19
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttagc agctatgcca tgagctgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcatct attagtggta gtggtgatta catatactac      180

gcagactccg tgaagggccg gttcaccatc tccagagaca tatccaagaa cacgctgtat      240

ctgcaaatga acagcctgag agccgaggac acggccgtat attactgtgc gaaagaaggt      300

acgggtgcca acagcagctt ggcagactac agaggccagg gcaccctggt caccgtctcc      360

tca                                                                    363


<210> 20
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"


<220>
<221> VARIANT
<222> (5)..(5)
<223> /replace="Thr"

<220>
<221> VARIANT
<222> (6)..(6)
<223> /replace="Asn"

<220>
<221> VARIANT
<222> (7)..(7)
<223> /replace="Tyr"

<220>
<221> SITE
<222> (1)..(8)
<223> /note="Variant residues given in the sequence have no 
      preference with respect to those in the annotations 
      for variant positions"

<400> 20
Gly Phe Thr Phe Ser Ser His Ala 
1               5               


<210> 21
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"


<220>
<221> VARIANT
<222> (4)..(4)
<223> /replace="Asn"

<220>
<221> VARIANT
<222> (6)..(6)
<223> /replace="Arg"

<220>
<221> VARIANT
<222> (7)..(7)
<223> /replace="Phe" or "Tyr"

<220>
<221> VARIANT
<222> (8)..(8)
<223> /replace="Ile"

<220>
<221> SITE
<222> (1)..(8)
<223> /note="Variant residues given in the sequence have no 
      preference with respect to those in the annotations 
      for variant positions"

<400> 21
Ile Ser Gly Ser Gly Asp Thr Thr 
1               5               
