                         SEQUENCE LISTING

<110>  iCell Gene Therapeutics LLC
 
<120>  Chimeric Antigen Receptors (CARs), Compositions and Methods  
       Thereof

<130>  2541-3 P2

<160>  252   

<170>  PatentIn version 3.5

<210>  1
<211>  830
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  1

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu 
            20                  25                  30          


Ala Val Ser Leu Gly Glu Arg Val Thr Met Asn Cys Lys Ser Ser Gln 
        35                  40                  45              


Ser Leu Leu Tyr Ser Thr Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln 
    50                  55                  60                  


Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr 
65                  70                  75                  80  


Arg Glu Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr 
                85                  90                  95      


Asp Phe Thr Leu Thr Ile Ser Ser Val Gln Ala Glu Asp Val Ala Val 
            100                 105                 110         


Tyr Tyr Cys Gln Gln Tyr Tyr Ser Tyr Arg Thr Phe Gly Gly Gly Thr 
        115                 120                 125             


Lys Leu Glu Ile Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Val Val 
145                 150                 155                 160 


Lys Pro Gly Ala Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr 
                165                 170                 175     


Phe Thr Ser Tyr Val Ile His Trp Val Arg Gln Lys Pro Gly Gln Gly 
            180                 185                 190         


Leu Asp Trp Ile Gly Tyr Ile Asn Pro Tyr Asn Asp Gly Thr Asp Tyr 
        195                 200                 205             


Asp Glu Lys Phe Lys Gly Lys Ala Thr Leu Thr Ser Asp Thr Ser Thr 
    210                 215                 220                 


Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala 
225                 230                 235                 240 


Val Tyr Tyr Cys Ala Arg Glu Lys Asp Asn Tyr Ala Thr Gly Ala Trp 
                245                 250                 255     


Phe Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Thr Thr 
            260                 265                 270         


Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln 
        275                 280                 285             


Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala 
    290                 295                 300                 


Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala 
305                 310                 315                 320 


Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr 
                325                 330                 335     


Leu Tyr Cys Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met 
            340                 345                 350         


Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro 
        355                 360                 365             


Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Lys Arg Gly Arg 
    370                 375                 380                 


Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln 
385                 390                 395                 400 


Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu 
                405                 410                 415     


Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala 
            420                 425                 430         


Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu 
        435                 440                 445             


Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp 
    450                 455                 460                 


Pro Glu Met Gly Gly Lys Pro Gln Arg Arg Lys Asn Pro Gln Glu Gly 
465                 470                 475                 480 


Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu 
                485                 490                 495     


Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu 
            500                 505                 510         


Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His 
        515                 520                 525             


Met Gln Ala Leu Pro Pro Arg Gly Ser Gly Ala Thr Asn Phe Ser Leu 
    530                 535                 540                 


Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met Tyr Arg 
545                 550                 555                 560 


Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu Val Thr Asn 
                565                 570                 575     


Ser Gly Ile His Val Phe Ile Leu Gly Cys Phe Ser Ala Gly Leu Pro 
            580                 585                 590         


Lys Thr Glu Ala Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys Ile 
        595                 600                 605             


Glu Asp Leu Ile Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr Glu 
    610                 615                 620                 


Ser Asp Val His Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe Leu 
625                 630                 635                 640 


Leu Glu Leu Gln Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile His 
                645                 650                 655     


Asp Thr Val Glu Asn Leu Ile Ile Leu Ala Asn Asn Ser Leu Ser Ser 
            660                 665                 670         


Asn Gly Asn Val Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu 
        675                 680                 685             


Glu Lys Asn Ile Lys Glu Phe Leu Gln Ser Phe Val His Ile Val Gln 
    690                 695                 700                 


Met Phe Ile Asn Thr Ser Ser Gly Gly Gly Ser Gly Gly Gly Gly Ser 
705                 710                 715                 720 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Leu Gln 
                725                 730                 735     


Ala Pro Arg Arg Ala Arg Gly Cys Arg Thr Leu Gly Leu Pro Ala Leu 
            740                 745                 750         


Leu Leu Leu Leu Leu Leu Arg Pro Pro Ala Thr Arg Gly Ile Thr Cys 
        755                 760                 765             


Pro Pro Pro Met Ser Val Glu His Ala Asp Ile Trp Val Lys Ser Tyr 
    770                 775                 780                 


Ser Leu Tyr Ser Arg Glu Arg Tyr Ile Cys Asn Ser Gly Phe Lys Arg 
785                 790                 795                 800 


Lys Ala Gly Thr Ser Ser Leu Thr Glu Cys Val Leu Asn Lys Ala Thr 
                805                 810                 815     


Asn Val Ala His Trp Thr Thr Pro Ser Leu Lys Cys Ile Arg 
            820                 825                 830 


<210>  2
<211>  2509
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  2
gcgatcgcat ggccttacca gtgaccgcct tgctcctgcc gctggccttg ctgctccacg       60

ccgccaggcc ggacatcgtg atgacccaaa gccccgacag cctggccgtg agcctgggcg      120

agagggtgac catgaactgc aaaagcagcc agtccctgct gtactccacc aaccagaaga      180

actacctggc ttggtatcaa cagaagcccg gacagagccc caagctgctg atctattggg      240

ccagcactag ggaaagcggc gtgcccgata ggttcagcgg cagcgggagc ggcacagact      300

tcactctgac cattagcagc gtgcaggctg aggatgtggc cgtctactac tgccagcagt      360

actacagcta caggaccttt gggggcggaa ctaagctgga gatcaaggga ggggggggat      420

ccgggggagg aggctccggc ggaggcggaa gccaagtgca actgcagcag agcggcccag      480

aggtggtcaa acctggggca agcgtgaaga tgagctgcaa ggctagcggc tataccttca      540

ccagctatgt gatccactgg gtgaggcaga aaccaggaca gggcctggac tggatcggct      600

acatcaaccc ctacaatgac ggcaccgatt atgacgaaaa attcaagggg aaggccaccc      660

tgaccagcga caccagcaca agcaccgcct acatggagct gtccagcctg aggtccgagg      720

acaccgccgt gtattactgt gccagggaga aggacaatta cgccaccggc gcttggttcg      780

cctactgggg ccagggcaca ctggtgacag tgagcagcac cacgacgcca gcgccgcgac      840

caccaacacc ggcgcccacc atcgcgtcgc agcccctgtc cctgcgccca gaggcgtgcc      900

ggccagcggc ggggggcgca gtgcacacga gggggctgga cttcgcctgt gatatctaca      960

tctgggcgcc cttggccggg acttgtgggg tccttctcct gtcactggtt atcacccttt     1020

actgcaggag taagaggagc aggctcctgc acagtgacta catgaacatg actccccgcc     1080

gccccgggcc cacccgcaag cattaccagc cctatgcccc accacgcgac ttcgcagcct     1140

atcgctccaa acggggcaga aagaaactcc tgtatatatt caaacaacca tttatgagac     1200

cagtacaaac tactcaagag gaagatggct gtagctgccg atttccagaa gaagaagaag     1260

gaggatgtga actgagagtg aagttcagca ggagcgcaga cgcccccgcg taccagcagg     1320

gccagaacca gctctataac gagctcaatc taggacgaag agaggagtac gatgttttgg     1380

acaagagacg tggccgggac cctgagatgg ggggaaagcc gcagagaagg aagaaccctc     1440

aggaaggcct gtacaatgaa ctgcagaaag ataagatggc ggaggcctac agtgagattg     1500

ggatgaaagg cgagcgccgg aggggcaagg ggcacgatgg cctttaccag ggtctcagta     1560

cagccaccaa ggacacctac gacgcccttc acatgcaggc cctgccccct cgcggaagcg     1620

gagccaccaa cttcagcctg ctgaagcagg ccggcgacgt ggaggagaac cccggcccca     1680

tgtacagaat gcagctgctg agctgcatcg ccctgagcct ggccctggtg accaacagcg     1740

gcatccacgt gttcatcctg ggctgcttca gcgccggcct gcccaagacc gaggccaact     1800

gggtgaacgt gatcagcgac ctgaagaaga tcgaggacct gatccagagc atgcacatcg     1860

acgccaccct gtacaccgag agcgacgtgc accccagctg caaggtgacc gccatgaagt     1920

gcttcctgct ggagctgcag gtgatcagcc tggagagcgg cgacgccagc atccacgaca     1980

ccgtggagaa cctgatcatc ctggccaaca acagcctgag cagcaacggc aacgtgaccg     2040

agagcggctg caaggagtgc gaggagctgg aggagaagaa catcaaggag ttcctgcaga     2100

gcttcgtgca catcgtgcag atgttcatca acaccagctc cggcggcggc tccggcggcg     2160

gcggctccgg cggcggcggc tccggcggcg gcggctccgg cggcggctcc ctgcaggccc     2220

ccagaagagc cagaggctgc agaaccctgg gcctgcccgc cctgctgctg ctgctgctgc     2280

tgagaccccc cgccaccaga ggcatcacct gccccccccc catgagcgtg gagcacgccg     2340

acatctgggt gaagagctac agcctgtaca gcagagagag atacatctgc aacagcggct     2400

tcaagagaaa ggccggcacc agcagcctga ccgagtgcgt gctgaacaag gccaccaacg     2460

tggcccactg gaccaccccc agcctgaagt gcatcagata agtttaaac                 2509


<210>  3
<211>  995
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  3

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu 
            20                  25                  30          


Ser Ala Ser Leu Gly Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln 
        35                  40                  45              


Asp Ile Ser Lys Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr 
    50                  55                  60                  


Val Lys Leu Leu Ile Tyr His Thr Ser Arg Leu His Ser Gly Val Pro 
65                  70                  75                  80  


Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile 
                85                  90                  95      


Ser Asn Leu Glu Gln Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly 
            100                 105                 110         


Asn Thr Leu Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Thr 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu 
    130                 135                 140                 


Val Lys Leu Gln Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln Ser 
145                 150                 155                 160 


Leu Ser Val Thr Cys Thr Val Ser Gly Val Ser Leu Pro Asp Tyr Gly 
                165                 170                 175     


Val Ser Trp Ile Arg Gln Pro Pro Arg Lys Gly Leu Glu Trp Leu Gly 
            180                 185                 190         


Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr Asn Ser Ala Leu Lys Ser 
        195                 200                 205             


Arg Leu Thr Ile Ile Lys Asp Asn Ser Lys Ser Gln Val Phe Leu Lys 
    210                 215                 220                 


Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Ile Tyr Tyr Cys Ala Lys 
225                 230                 235                 240 


His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly 
                245                 250                 255     


Thr Ser Val Thr Val Ser Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro 
            260                 265                 270         


Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu 
        275                 280                 285             


Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp 
    290                 295                 300                 


Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly 
305                 310                 315                 320 


Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg 
                325                 330                 335     


Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln 
            340                 345                 350         


Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu 
        355                 360                 365             


Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala 
    370                 375                 380                 


Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu 
385                 390                 395                 400 


Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp 
                405                 410                 415     


Pro Glu Met Gly Gly Lys Pro Gln Arg Arg Lys Asn Pro Gln Glu Gly 
            420                 425                 430         


Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu 
        435                 440                 445             


Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu 
    450                 455                 460                 


Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His 
465                 470                 475                 480 


Met Gln Ala Leu Pro Pro Arg Gly Ser Gly Ala Thr Asn Phe Ser Leu 
                485                 490                 495     


Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met Ala Leu 
            500                 505                 510         


Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu His Ala Ala 
        515                 520                 525             


Arg Pro Gln Ile Val Leu Ser Gln Ser Pro Ala Ile Leu Ser Ala Ser 
    530                 535                 540                 


Pro Gly Glu Lys Val Thr Met Thr Cys Arg Ala Ser Ser Ser Val Ser 
545                 550                 555                 560 


Tyr Ile His Trp Phe Gln Gln Lys Pro Gly Ser Ser Pro Lys Pro Trp 
                565                 570                 575     


Ile Tyr Ala Thr Ser Asn Leu Ala Ser Gly Val Pro Val Arg Phe Ser 
            580                 585                 590         


Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Val Glu 
        595                 600                 605             


Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Thr Ser Asn Pro 
    610                 615                 620                 


Pro Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Gly Gly Gly Gly 
625                 630                 635                 640 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Gln 
                645                 650                 655     


Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Ala Ser Val Lys Met Ser 
            660                 665                 670         


Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr Asn Met His Trp Val 
        675                 680                 685             


Lys Gln Thr Pro Gly Arg Gly Leu Glu Trp Ile Gly Ala Ile Tyr Pro 
    690                 695                 700                 


Gly Asn Gly Asp Thr Ser Tyr Asn Gln Lys Phe Lys Gly Lys Ala Thr 
705                 710                 715                 720 


Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr Met Gln Leu Ser Ser 
                725                 730                 735     


Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys Ala Arg Ser Thr Tyr 
            740                 745                 750         


Tyr Gly Gly Asp Trp Tyr Phe Asn Val Trp Gly Ala Gly Thr Thr Val 
        755                 760                 765             


Thr Val Ser Ala Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala 
    770                 775                 780                 


Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg 
785                 790                 795                 800 


Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys 
                805                 810                 815     


Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu 
            820                 825                 830         


Leu Ser Leu Val Ile Thr Leu Tyr Cys Arg Ser Lys Arg Ser Arg Leu 
        835                 840                 845             


Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr 
    850                 855                 860                 


Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr 
865                 870                 875                 880 


Arg Ser Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln 
                885                 890                 895     


Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu 
            900                 905                 910         


Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly 
        915                 920                 925             


Gly Lys Pro Gln Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu 
    930                 935                 940                 


Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys 
945                 950                 955                 960 


Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu 
                965                 970                 975     


Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu 
            980                 985                 990         


Pro Pro Arg 
        995 


<210>  4
<211>  3004
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  4
gcgatcgcat ggccttacca gtgaccgcct tgctcctgcc gctggccttg ctgctccacg       60

ccgccaggcc ggacatccag atgacacaga ctacatcctc cctgtctgcc tctctgggag      120

acagagtcac catcagttgc agggcaagtc aggacattag taaatattta aattggtatc      180

agcagaaacc agatggaact gttaaactcc tgatctacca tacatcaaga ttacactcag      240

gagtcccatc aaggttcagt ggcagtgggt ctggaacaga ttattctctc accattagca      300

acctggagca agaagatatt gccacttact tttgccaaca gggtaatacg cttccgtaca      360

cgttcggagg ggggaccaag ctggagatca caggtggcgg tggctcgggc ggtggtgggt      420

cgggtggcgg cggatctgag gtgaaactgc aggagtcagg acctggcctg gtggcgccct      480

cacagagcct gtccgtcaca tgcactgtct caggggtctc attacccgac tatggtgtaa      540

gctggattcg ccagcctcca cgaaagggtc tggagtggct gggagtaata tggggtagtg      600

aaaccacata ctataattca gctctcaaat ccagactgac catcatcaag gacaactcca      660

agagccaagt tttcttaaaa atgaacagtc tgcaaactga tgacacagcc atttactact      720

gtgccaaaca ttattactac ggtggtagct atgctatgga ctactggggc caaggaacct      780

cagtcaccgt ctcctcaacc acgacgccag cgccgcgacc accaacaccg gcgcccacca      840

tcgcgtcgca gcccctgtcc ctgcgcccag aggcgtgccg gccagcggcg gggggcgcag      900

tgcacacgag ggggctggac ttcgcctgtg atatctacat ctgggcgccc ttggccggga      960

cttgtggggt ccttctcctg tcactggtta tcacccttta ctgcaaacgg ggcagaaaga     1020

aactcctgta tatattcaaa caaccattta tgagaccagt acaaactact caagaggaag     1080

atggctgtag ctgccgattt ccagaagaag aagaaggagg atgtgaactg agagtgaagt     1140

tcagcaggag cgcagacgcc cccgcgtacc agcagggcca gaaccagctc tataacgagc     1200

tcaatctagg acgaagagag gagtacgatg ttttggacaa gagacgtggc cgggaccctg     1260

agatgggggg aaagccgcag agaaggaaga accctcagga aggcctgtac aatgaactgc     1320

agaaagataa gatggcggag gcctacagtg agattgggat gaaaggcgag cgccggaggg     1380

gcaaggggca cgatggcctt taccagggtc tcagtacagc caccaaggac acctacgacg     1440

cccttcacat gcaggccctg ccccctcgcg gaagcggagc caccaacttc agcctgctga     1500

agcaggccgg cgacgtggag gagaaccccg gccccatggc cttaccagtg accgccttgc     1560

tcctgccgct ggccttgctg ctccacgccg ccaggccgca gatcgtgctg agccagagcc     1620

ctgccatcct gtccgcaagc ccaggcgaga aggtgaccat gacctgtagg gccagcagct     1680

ccgtgagcta catccactgg tttcagcaga agcctggaag cagccctaag ccctggatct     1740

acgccacaag caatctggct agcggcgtgc ccgtgaggtt cagcggcagc gggagcggga     1800

ccagctacag cctgactatc agcagggtgg aggccgagga cgccgccaca tactactgcc     1860

aacagtggac ctccaaccca cccacctttg gaggagggac aaaactggag atcaaagggg     1920

gcggagggtc cggaggcggc ggaagcgggg gagggggaag ccaggtccaa ctgcaacagc     1980

ccggagcaga actggtcaaa ccaggcgcca gcgtgaagat gagctgcaag gccagcgggt     2040

acaccttcac ttcctataac atgcactggg tgaagcagac cccaggaagg ggcctggagt     2100

ggatcggggc aatctatccc ggcaacggcg acacaagcta caaccagaag ttcaagggga     2160

aagccactct gaccgccgac aagtccagct ccaccgccta catgcagctg agctccctga     2220

ccagcgagga cagcgccgtg tactattgcg ccagaagcac ttattacgga ggggactggt     2280

acttcaacgt gtggggggca gggaccaccg tgaccgtgtc cgccaccacg acgccagcgc     2340

cgcgaccacc aacaccggcg cccaccatcg cgtcgcagcc cctgtccctg cgcccagagg     2400

cgtgccggcc agcggcgggg ggcgcagtgc acacgagggg gctggacttc gcctgtgata     2460

tctacatctg ggcgcccttg gccgggactt gtggggtcct tctcctgtca ctggttatca     2520

ccctttactg caggagtaag aggagcaggc tcctgcacag tgactacatg aacatgactc     2580

cccgccgccc cgggcccacc cgcaagcatt accagcccta tgccccacca cgcgacttcg     2640

cagcctatcg ctccagagtg aagttcagca ggagcgcaga cgcccccgcg taccagcagg     2700

gccagaacca gctctataac gagctcaatc taggacgaag agaggagtac gatgttttgg     2760

acaagagacg tggccgggac cctgagatgg ggggaaagcc gcagagaagg aagaaccctc     2820

aggaaggcct gtacaatgaa ctgcagaaag ataagatggc ggaggcctac agtgagattg     2880

ggatgaaagg cgagcgccgg aggggcaagg ggcacgatgg cctttaccag ggtctcagta     2940

cagccaccaa ggacacctac gacgcccttc acatgcaggc cctgccccct cgctaagttt     3000

aaac                                                                  3004


<210>  5
<211>  1001
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  5

Asp Arg Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu 
1               5                   10                  15      


Leu Leu His Ala Ala Arg Pro Asp Ile Gln Met Thr Gln Thr Thr Ser 
            20                  25                  30          


Ser Leu Ser Ala Ser Leu Gly Asp Arg Val Thr Ile Ser Cys Arg Ala 
        35                  40                  45              


Ser Gln Asp Ile Ser Lys Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Asp 
    50                  55                  60                  


Gly Thr Val Lys Leu Leu Ile Tyr His Thr Ser Arg Leu His Ser Gly 
65                  70                  75                  80  


Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser Leu 
                85                  90                  95      


Thr Ile Ser Asn Leu Glu Gln Glu Asp Ile Ala Thr Tyr Phe Cys Gln 
            100                 105                 110         


Gln Gly Asn Thr Leu Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu 
        115                 120                 125             


Ile Thr Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Glu Val Lys Leu Gln Glu Ser Gly Pro Gly Leu Val Ala Pro Ser 
145                 150                 155                 160 


Gln Ser Leu Ser Val Thr Cys Thr Val Ser Gly Val Ser Leu Pro Asp 
                165                 170                 175     


Tyr Gly Val Ser Trp Ile Arg Gln Pro Pro Arg Lys Gly Leu Glu Trp 
            180                 185                 190         


Leu Gly Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr Asn Ser Ala Leu 
        195                 200                 205             


Lys Ser Arg Leu Thr Ile Ile Lys Asp Asn Ser Lys Ser Gln Val Phe 
    210                 215                 220                 


Leu Lys Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Ile Tyr Tyr Cys 
225                 230                 235                 240 


Ala Lys His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr Trp Gly 
                245                 250                 255     


Gln Gly Thr Ser Val Thr Val Ser Ser Thr Thr Thr Pro Ala Pro Arg 
            260                 265                 270         


Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg 
        275                 280                 285             


Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly 
    290                 295                 300                 


Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr 
305                 310                 315                 320 


Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg 
                325                 330                 335     


Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro 
            340                 345                 350         


Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu 
        355                 360                 365             


Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala 
    370                 375                 380                 


Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu 
385                 390                 395                 400 


Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly 
                405                 410                 415     


Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu 
            420                 425                 430         


Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser 
        435                 440                 445             


Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly 
    450                 455                 460                 


Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu 
465                 470                 475                 480 


His Met Gln Ala Leu Pro Pro Arg Gly Ser Gly Ala Thr Asn Phe Ser 
                485                 490                 495     


Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met Ala 
            500                 505                 510         


Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu His Ala 
        515                 520                 525             


Ala Arg Pro Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala 
    530                 535                 540                 


Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ser Ser Gln Ser Ile 
545                 550                 555                 560 


Val His Ser Val Gly Asn Thr Phe Leu Glu Trp Tyr Gln Gln Lys Pro 
                565                 570                 575     


Gly Lys Ala Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser 
            580                 585                 590         


Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
        595                 600                 605             


Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys 
    610                 615                 620                 


Phe Gln Gly Ser Gln Phe Pro Tyr Thr Phe Gly Gln Gly Thr Lys Val 
625                 630                 635                 640 


Glu Ile Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
                645                 650                 655     


Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro 
            660                 665                 670         


Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Glu Phe Ser 
        675                 680                 685             


Arg Ser Trp Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu 
    690                 695                 700                 


Trp Val Gly Arg Ile Tyr Pro Gly Asp Gly Asp Thr Asn Tyr Ser Gly 
705                 710                 715                 720 


Lys Phe Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr 
                725                 730                 735     


Ala Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
            740                 745                 750         


Tyr Cys Ala Arg Asp Gly Ser Ser Trp Asp Trp Tyr Phe Asp Val Trp 
        755                 760                 765             


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Thr Thr Thr Pro Ala Pro 
    770                 775                 780                 


Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu 
785                 790                 795                 800 


Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg 
                805                 810                 815     


Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly 
            820                 825                 830         


Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys 
        835                 840                 845             


Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg 
    850                 855                 860                 


Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro 
865                 870                 875                 880 


Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser 
                885                 890                 895     


Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu 
            900                 905                 910         


Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg 
        915                 920                 925             


Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln 
    930                 935                 940                 


Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr 
945                 950                 955                 960 


Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp 
                965                 970                 975     


Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala 
            980                 985                 990         


Leu His Met Gln Ala Leu Pro Pro  Arg 
        995                 1000     


<210>  6
<211>  3016
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  6
gcgatcgcat ggccttacca gtgaccgcct tgctcctgcc gctggccttg ctgctccacg       60

ccgccaggcc ggacatccag atgacacaga ctacatcctc cctgtctgcc tctctgggag      120

acagagtcac catcagttgc agggcaagtc aggacattag taaatattta aattggtatc      180

agcagaaacc agatggaact gttaaactcc tgatctacca tacatcaaga ttacactcag      240

gagtcccatc aaggttcagt ggcagtgggt ctggaacaga ttattctctc accattagca      300

acctggagca agaagatatt gccacttact tttgccaaca gggtaatacg cttccgtaca      360

cgttcggagg ggggaccaag ctggagatca caggtggcgg tggctcgggc ggtggtgggt      420

cgggtggcgg cggatctgag gtgaaactgc aggagtcagg acctggcctg gtggcgccct      480

cacagagcct gtccgtcaca tgcactgtct caggggtctc attacccgac tatggtgtaa      540

gctggattcg ccagcctcca cgaaagggtc tggagtggct gggagtaata tggggtagtg      600

aaaccacata ctataattca gctctcaaat ccagactgac catcatcaag gacaactcca      660

agagccaagt tttcttaaaa atgaacagtc tgcaaactga tgacacagcc atttactact      720

gtgccaaaca ttattactac ggtggtagct atgctatgga ctactggggc caaggaacct      780

cagtcaccgt ctcctcaacc acgacgccag cgccgcgacc accaacaccg gcgcccacca      840

tcgcgtcgca gcccctgtcc ctgcgcccag aggcgtgccg gccagcggcg gggggcgcag      900

tgcacacgag ggggctggac ttcgcctgtg atatctacat ctgggcgccc ttggccggga      960

cttgtggggt ccttctcctg tcactggtta tcacccttta ctgcaaacgg ggcagaaaga     1020

aactcctgta tatattcaaa caaccattta tgagaccagt acaaactact caagaggaag     1080

atggctgtag ctgccgattt ccagaagaag aagaaggagg atgtgaactg agagtgaagt     1140

tcagcaggag cgcagacgcc cccgcgtacc agcagggcca gaaccagctc tataacgagc     1200

tcaatctagg acgaagagag gagtacgatg ttttggacaa gagacgtggc cgggaccctg     1260

agatgggggg aaagccgaga aggaagaacc ctcaggaagg cctgtacaat gaactgcaga     1320

aagataagat ggcggaggcc tacagtgaga ttgggatgaa aggcgagcgc cggaggggca     1380

aggggcacga tggcctttac cagggtctca gtacagccac caaggacacc tacgacgccc     1440

ttcacatgca ggccctgccc cctcgcggaa gcggagccac caacttcagc ctgctgaagc     1500

aggccggcga cgtggaggag aaccccggcc ccatggcctt accagtgacc gccttgctcc     1560

tgccgctggc cttgctgctc cacgccgcca ggccggatat ccagatgacc cagagcccca     1620

gctccctgtc cgcatccgtg ggcgacagag tgacaattac ctgtagaagc agccaaagca     1680

tcgtgcatag cgtcggcaac acttttctgg agtggtatca acagaagccc gggaaggccc     1740

ccaaactgct gatctacaag gtgagcaaca gattcagcgg ggtcccaagc agattctccg     1800

gcagcggctc cgggactgac ttcaccctga ccattagcag cctgcagcca gaggacttcg     1860

ccacatacta ctgcttccaa gggagccagt tcccctacac cttcggccaa ggcactaagg     1920

tggagatcaa agggggggga ggaagcggcg gaggagggag cggaggcggg ggatccgaag     1980

tgcaactggt cgaatccgga ggggggctgg tccagcctgg agggtccctg agactgagct     2040

gcgccgcaag cggctacgag ttctccaggt cctggatgaa ctgggtgagg caggccccag     2100

gaaaagggct ggaatgggtg ggcaggatct accctggcga cggcgatacc aactactccg     2160

gaaagttcaa gggcaggttc actatcagcg ccgacactag caagaatacc gcctacctgc     2220

agatgaatag cctgagggcc gaggacaccg ccgtgtatta ctgcgctaga gacggcagca     2280

gctgggattg gtacttcgac gtgtggggcc agggcactct ggtgactgtg agcagcacca     2340

cgacgccagc gccgcgacca ccaacaccgg cgcccaccat cgcgtcgcag cccctgtccc     2400

tgcgcccaga ggcgtgccgg ccagcggcgg ggggcgcagt gcacacgagg gggctggact     2460

tcgcctgtga tatctacatc tgggcgccct tggccgggac ttgtggggtc cttctcctgt     2520

cactggttat caccctttac tgcaaacggg gcagaaagaa actcctgtat atattcaaac     2580

aaccatttat gagaccagta caaactactc aagaggaaga tggctgtagc tgccgatttc     2640

cagaagaaga agaaggagga tgtgaactga gagtgaagtt cagcaggagc gcagacgccc     2700

ccgcgtacca gcagggccag aaccagctct ataacgagct caatctagga cgaagagagg     2760

agtacgatgt tttggacaag agacgtggcc gggaccctga gatgggggga aagccgagaa     2820

ggaagaaccc tcaggaaggc ctgtacaatg aactgcagaa agataagatg gcggaggcct     2880

acagtgagat tgggatgaaa ggcgagcgcc ggaggggcaa ggggcacgat ggcctttacc     2940

agggtctcag tacagccacc aaggacacct acgacgccct tcacatgcag gccctgcccc     3000

ctcgctaagt ttaaac                                                     3016


<210>  7
<211>  990
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  7

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu 
            20                  25                  30          


Ser Ala Ser Leu Gly Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln 
        35                  40                  45              


Asp Ile Ser Lys Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr 
    50                  55                  60                  


Val Lys Leu Leu Ile Tyr His Thr Ser Arg Leu His Ser Gly Val Pro 
65                  70                  75                  80  


Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile 
                85                  90                  95      


Ser Asn Leu Glu Gln Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly 
            100                 105                 110         


Asn Thr Leu Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Thr 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu 
    130                 135                 140                 


Val Lys Leu Gln Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln Ser 
145                 150                 155                 160 


Leu Ser Val Thr Cys Thr Val Ser Gly Val Ser Leu Pro Asp Tyr Gly 
                165                 170                 175     


Val Ser Trp Ile Arg Gln Pro Pro Arg Lys Gly Leu Glu Trp Leu Gly 
            180                 185                 190         


Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr Asn Ser Ala Leu Lys Ser 
        195                 200                 205             


Arg Leu Thr Ile Ile Lys Asp Asn Ser Lys Ser Gln Val Phe Leu Lys 
    210                 215                 220                 


Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Ile Tyr Tyr Cys Ala Lys 
225                 230                 235                 240 


His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly 
                245                 250                 255     


Thr Ser Val Thr Val Ser Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro 
            260                 265                 270         


Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu 
        275                 280                 285             


Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp 
    290                 295                 300                 


Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly 
305                 310                 315                 320 


Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg 
                325                 330                 335     


Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln 
            340                 345                 350         


Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu 
        355                 360                 365             


Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala 
    370                 375                 380                 


Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu 
385                 390                 395                 400 


Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp 
                405                 410                 415     


Pro Glu Met Gly Gly Lys Pro Gln Arg Arg Lys Asn Pro Gln Glu Gly 
            420                 425                 430         


Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu 
        435                 440                 445             


Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu 
    450                 455                 460                 


Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His 
465                 470                 475                 480 


Met Gln Ala Leu Pro Pro Arg Gly Ser Gly Ala Thr Asn Phe Ser Leu 
                485                 490                 495     


Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met Ala Leu 
            500                 505                 510         


Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu His Ala Ala 
        515                 520                 525             


Arg Pro Asp Val Gln Ile Thr Gln Ser Pro Ser Tyr Leu Ala Ala Ser 
    530                 535                 540                 


Pro Gly Glu Thr Ile Thr Ile Asn Cys Arg Ala Ser Lys Ser Ile Ser 
545                 550                 555                 560 


Lys Asp Leu Ala Trp Tyr Gln Glu Lys Pro Gly Lys Thr Asn Lys Leu 
                565                 570                 575     


Leu Ile Tyr Ser Gly Ser Thr Leu Gln Ser Gly Ile Pro Ser Arg Phe 
            580                 585                 590         


Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu 
        595                 600                 605             


Glu Pro Glu Asp Phe Ala Met Tyr Tyr Cys Gln Gln His Asn Lys Tyr 
    610                 615                 620                 


Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Gly Gly Gly 
625                 630                 635                 640 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu 
                645                 650                 655     


Gln Gln Pro Gly Ala Glu Leu Val Arg Pro Gly Ala Ser Val Lys Leu 
            660                 665                 670         


Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr Trp Met Asn Trp 
        675                 680                 685             


Val Lys Gln Arg Pro Asp Gln Gly Leu Glu Trp Ile Gly Arg Ile Asp 
    690                 695                 700                 


Pro Tyr Asp Ser Glu Thr His Tyr Asn Gln Lys Phe Lys Asp Lys Ala 
705                 710                 715                 720 


Ile Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr Met Gln Leu Ser 
                725                 730                 735     


Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys Ala Arg Gly Asn 
            740                 745                 750         


Trp Asp Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser Thr 
        755                 760                 765             


Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser 
    770                 775                 780                 


Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly 
785                 790                 795                 800 


Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp 
                805                 810                 815     


Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile 
            820                 825                 830         


Thr Leu Tyr Cys Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr 
        835                 840                 845             


Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln 
    850                 855                 860                 


Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Arg Val Lys 
865                 870                 875                 880 


Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln 
                885                 890                 895     


Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu 
            900                 905                 910         


Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Gln Arg 
        915                 920                 925             


Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys 
    930                 935                 940                 


Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg 
945                 950                 955                 960 


Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys 
                965                 970                 975     


Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            980                 985                 990 


<210>  8
<211>  2989
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  8
gcgatcgcat ggccttacca gtgaccgcct tgctcctgcc gctggccttg ctgctccacg       60

ccgccaggcc ggacatccag atgacacaga ctacatcctc cctgtctgcc tctctgggag      120

acagagtcac catcagttgc agggcaagtc aggacattag taaatattta aattggtatc      180

agcagaaacc agatggaact gttaaactcc tgatctacca tacatcaaga ttacactcag      240

gagtcccatc aaggttcagt ggcagtgggt ctggaacaga ttattctctc accattagca      300

acctggagca agaagatatt gccacttact tttgccaaca gggtaatacg cttccgtaca      360

cgttcggagg ggggaccaag ctggagatca caggtggcgg tggctcgggc ggtggtgggt      420

cgggtggcgg cggatctgag gtgaaactgc aggagtcagg acctggcctg gtggcgccct      480

cacagagcct gtccgtcaca tgcactgtct caggggtctc attacccgac tatggtgtaa      540

gctggattcg ccagcctcca cgaaagggtc tggagtggct gggagtaata tggggtagtg      600

aaaccacata ctataattca gctctcaaat ccagactgac catcatcaag gacaactcca      660

agagccaagt tttcttaaaa atgaacagtc tgcaaactga tgacacagcc atttactact      720

gtgccaaaca ttattactac ggtggtagct atgctatgga ctactggggc caaggaacct      780

cagtcaccgt ctcctcaacc acgacgccag cgccgcgacc accaacaccg gcgcccacca      840

tcgcgtcgca gcccctgtcc ctgcgcccag aggcgtgccg gccagcggcg gggggcgcag      900

tgcacacgag ggggctggac ttcgcctgtg atatctacat ctgggcgccc ttggccggga      960

cttgtggggt ccttctcctg tcactggtta tcacccttta ctgcaaacgg ggcagaaaga     1020

aactcctgta tatattcaaa caaccattta tgagaccagt acaaactact caagaggaag     1080

atggctgtag ctgccgattt ccagaagaag aagaaggagg atgtgaactg agagtgaagt     1140

tcagcaggag cgcagacgcc cccgcgtacc agcagggcca gaaccagctc tataacgagc     1200

tcaatctagg acgaagagag gagtacgatg ttttggacaa gagacgtggc cgggaccctg     1260

agatgggggg aaagccgcag agaaggaaga accctcagga aggcctgtac aatgaactgc     1320

agaaagataa gatggcggag gcctacagtg agattgggat gaaaggcgag cgccggaggg     1380

gcaaggggca cgatggcctt taccagggtc tcagtacagc caccaaggac acctacgacg     1440

cccttcacat gcaggccctg ccccctcgcg gaagcggagc caccaacttc agcctgctga     1500

agcaggccgg cgacgtggag gagaaccccg gccccatggc cttaccagtg accgccttgc     1560

tcctgccgct ggccttgctg ctccacgccg ccaggccgga cgtgcagatc acccagagcc     1620

ccagctacct ggccgccagc cccggcgaga ccatcaccat caactgcaga gccagcaaga     1680

gcatcagcaa ggacctggcc tggtaccagg agaagcccgg caagaccaac aagctgctga     1740

tctacagcgg cagcaccctg cagagcggca tccccagcag attcagcggc agcggcagcg     1800

gcaccgactt caccctgacc atcagcagcc tggagcccga ggacttcgcc atgtactact     1860

gccagcagca caacaagtac ccctacacct tcggcggcgg caccaagctg gagatcaagg     1920

gagggggggg atccggggga ggaggctccg gcggaggcgg aagccaggtg cagctgcagc     1980

agcccggcgc cgagctggtg agacccggcg ccagcgtgaa gctgagctgc aaggccagcg     2040

gctacacctt caccagctac tggatgaact gggtgaagca gagacccgac cagggcctgg     2100

agtggatcgg cagaatcgac ccctacgaca gcgagaccca ctacaaccag aagttcaagg     2160

acaaggccat cctgaccgtg gacaagagca gcagcaccgc ctacatgcag ctgagcagcc     2220

tgaccagcga ggacagcgcc gtgtactact gcgccagagg caactgggac gactactggg     2280

gccagggcac caccctgacc gtgagcagca ccacgacgcc agcgccgcga ccaccaacac     2340

cggcgcccac catcgcgtcg cagcccctgt ccctgcgccc agaggcgtgc cggccagcgg     2400

cggggggcgc agtgcacacg agggggctgg acttcgcctg tgatatctac atctgggcgc     2460

ccttggccgg gacttgtggg gtccttctcc tgtcactggt tatcaccctt tactgcagga     2520

gtaagaggag caggctcctg cacagtgact acatgaacat gactccccgc cgccccgggc     2580

ccacccgcaa gcattaccag ccctatgccc caccacgcga cttcgcagcc tatcgctcca     2640

gagtgaagtt cagcaggagc gcagacgccc ccgcgtacca gcagggccag aaccagctct     2700

ataacgagct caatctagga cgaagagagg agtacgatgt tttggacaag agacgtggcc     2760

gggaccctga gatgggggga aagccgcaga gaaggaagaa ccctcaggaa ggcctgtaca     2820

atgaactgca gaaagataag atggcggagg cctacagtga gattgggatg aaaggcgagc     2880

gccggagggg caaggggcac gatggccttt accagggtct cagtacagcc accaaggaca     2940

cctacgacgc ccttcacatg caggccctgc cccctcgcta agtttaaac                 2989


<210>  9
<211>  1066
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  9

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gln Ile Val Leu Thr Gln Ser Pro Ala Ile Met 
            20                  25                  30          


Ser Ala Ser Pro Gly Glu Lys Val Thr Ile Thr Cys Ser Ala Ser Ser 
        35                  40                  45              


Ser Ile Ser Tyr Met His Trp Phe Gln Gln Lys Pro Gly Thr Ser Pro 
    50                  55                  60                  


Lys Leu Trp Ile Tyr Thr Thr Ser Asn Leu Ala Ser Gly Val Pro Ala 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser 
                85                  90                  95      


Arg Met Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys His Gln Arg Ser 
            100                 105                 110         


Thr Tyr Pro Leu Thr Phe Gly Ser Gly Thr Lys Leu Glu Leu Lys Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val 
    130                 135                 140                 


Gln Leu Gln Gln Ser Gly Ala Glu Leu Ala Lys Pro Gly Ala Ser Val 
145                 150                 155                 160 


Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr Arg Met 
                165                 170                 175     


His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile Gly Tyr 
            180                 185                 190         


Ile Asn Pro Ser Thr Gly Tyr Thr Glu Tyr Asn Gln Lys Phe Lys Asp 
        195                 200                 205             


Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr Met Gln 
    210                 215                 220                 


Leu Ser Ser Leu Thr Phe Glu Asp Ser Ala Val Tyr Tyr Cys Ala Arg 
225                 230                 235                 240 


Gly Gly Gly Val Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val 
                245                 250                 255     


Ser Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr 
            260                 265                 270         


Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala 
        275                 280                 285             


Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile 
    290                 295                 300                 


Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser 
305                 310                 315                 320 


Leu Val Ile Thr Leu Tyr Cys Arg Ser Lys Arg Ser Arg Leu Leu His 
                325                 330                 335     


Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys 
            340                 345                 350         


His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser 
        355                 360                 365             


Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met 
    370                 375                 380                 


Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe 
385                 390                 395                 400 


Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg 
                405                 410                 415     


Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn 
            420                 425                 430         


Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg 
        435                 440                 445             


Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro 
    450                 455                 460                 


Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala 
465                 470                 475                 480 


Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His 
                485                 490                 495     


Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp 
            500                 505                 510         


Ala Leu His Met Gln Ala Leu Pro Pro Arg Gly Ser Gly Ala Thr Asn 
        515                 520                 525             


Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro 
    530                 535                 540                 


Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
545                 550                 555                 560 


His Ala Ala Arg Pro Asp Val Gln Ile Thr Gln Ser Pro Ser Tyr Leu 
                565                 570                 575     


Ala Ala Ser Pro Gly Glu Thr Ile Thr Ile Asn Cys Arg Ala Ser Lys 
            580                 585                 590         


Ser Ile Ser Lys Asp Leu Ala Trp Tyr Gln Glu Lys Pro Gly Lys Thr 
        595                 600                 605             


Asn Lys Leu Leu Ile Tyr Ser Gly Ser Thr Leu Gln Ser Gly Ile Pro 
    610                 615                 620                 


Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile 
625                 630                 635                 640 


Ser Ser Leu Glu Pro Glu Asp Phe Ala Met Tyr Tyr Cys Gln Gln His 
                645                 650                 655     


Asn Lys Tyr Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            660                 665                 670         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln 
        675                 680                 685             


Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Arg Pro Gly Ala Ser 
    690                 695                 700                 


Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr Trp 
705                 710                 715                 720 


Met Asn Trp Val Lys Gln Arg Pro Asp Gln Gly Leu Glu Trp Ile Gly 
                725                 730                 735     


Arg Ile Asp Pro Tyr Asp Ser Glu Thr His Tyr Asn Gln Lys Phe Lys 
            740                 745                 750         


Asp Lys Ala Ile Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr Met 
        755                 760                 765             


Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys Ala 
    770                 775                 780                 


Arg Gly Asn Trp Asp Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val 
785                 790                 795                 800 


Ser Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr 
                805                 810                 815     


Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala 
            820                 825                 830         


Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile 
        835                 840                 845             


Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser 
    850                 855                 860                 


Leu Val Ile Thr Leu Tyr Cys Arg Ser Lys Arg Ser Arg Leu Leu His 
865                 870                 875                 880 


Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys 
                885                 890                 895     


His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser 
            900                 905                 910         


Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met 
        915                 920                 925             


Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe 
    930                 935                 940                 


Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg 
945                 950                 955                 960 


Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn 
                965                 970                 975     


Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg 
            980                 985                 990         


Arg Gly Arg Asp Pro Glu Met Gly  Gly Lys Pro Arg Arg  Lys Asn Pro 
        995                 1000                 1005             


Gln Glu  Gly Leu Tyr Asn Glu  Leu Gln Lys Asp Lys  Met Ala Glu 
    1010                 1015                 1020             


Ala Tyr  Ser Glu Ile Gly Met  Lys Gly Glu Arg Arg  Arg Gly Lys 
    1025                 1030                 1035             


Gly His  Asp Gly Leu Tyr Gln  Gly Leu Ser Thr Ala  Thr Lys Asp 
    1040                 1045                 1050             


Thr Tyr  Asp Ala Leu His Met  Gln Ala Leu Pro Pro  Arg 
    1055                 1060                 1065     


<210>  10
<211>  3217
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  10
gcgatcgcat ggccttacca gtgaccgcct tgctcctgcc gctggccttg ctgctccacg       60

ccgccaggcc gcagatcgtg ctgacccaga gccccgccat catgagcgcc agccccggcg      120

agaaggtgac catcacctgc agcgccagca gcagcatcag ctacatgcac tggttccagc      180

agaagcccgg caccagcccc aagctgtgga tctacaccac cagcaacctg gccagcggcg      240

tgcccgccag attcagcggc agcggcagcg gcaccagcta cagcctgacc atcagcagaa      300

tggaggccga ggacgccgcc acctactact gccaccagag aagcacctac cccctgacct      360

tcggcagcgg caccaagctg gagctgaagg gagggggggg atccggggga ggaggctccg      420

gcggaggcgg aagccaggtg cagctgcagc agagcggcgc cgagctggcc aagcccggcg      480

ccagcgtgaa gatgagctgc aaggccagcg gctacacctt caccagctac agaatgcact      540

gggtgaagca gagacccggc cagggcctgg agtggatcgg ctacatcaac cccagcaccg      600

gctacaccga gtacaaccag aagttcaagg acaaggccac cctgaccgcc gacaagagca      660

gcagcaccgc ctacatgcag ctgagcagcc tgaccttcga ggacagcgcc gtgtactact      720

gcgccagagg cggcggcgtg ttcgactact ggggccaggg caccaccctg accgtgagca      780

gcaccacgac gccagcgccg cgaccaccaa caccggcgcc caccatcgcg tcgcagcccc      840

tgtccctgcg cccagaggcg tgccggccag cggcgggggg cgcagtgcac acgagggggc      900

tggacttcgc ctgtgatatc tacatctggg cgcccttggc cgggacttgt ggggtccttc      960

tcctgtcact ggttatcacc ctttactgca ggagtaagag gagcaggctc ctgcacagtg     1020

actacatgaa catgactccc cgccgccccg ggcccacccg caagcattac cagccctatg     1080

ccccaccacg cgacttcgca gcctatcgct ccaaacgggg cagaaagaaa ctcctgtata     1140

tattcaaaca accatttatg agaccagtac aaactactca agaggaagat ggctgtagct     1200

gccgatttcc agaagaagaa gaaggaggat gtgaactgag agtgaagttc agcaggagcg     1260

cagacgcccc cgcgtacaag cagggccaga accagctcta taacgagctc aatctaggac     1320

gaagagagga gtacgatgtt ttggacaaga gacgtggccg ggaccctgag atggggggaa     1380

agccgagaag gaagaaccct caggaaggcc tgtacaatga actgcagaaa gataagatgg     1440

cggaggccta cagtgagatt gggatgaaag gcgagcgccg gaggggcaag gggcacgatg     1500

gcctttacca gggtctcagt acagccacca aggacaccta cgacgccctt cacatgcagg     1560

ccctgccccc tcgcggaagc ggagctacta acttcagcct gctgaagcag gctggagacg     1620

tggaggagaa ccctggacct atggccttac cagtgaccgc cttgctcctg ccgctggcct     1680

tgctgctcca cgccgccagg ccggacgtgc agatcaccca gagccccagc tacctggccg     1740

ccagccccgg cgagaccatc accatcaact gcagagccag caagagcatc agcaaggacc     1800

tggcctggta ccaggagaag cccggcaaga ccaacaagct gctgatctac agcggcagca     1860

ccctgcagag cggcatcccc agcagattca gcggcagcgg cagcggcacc gacttcaccc     1920

tgaccatcag cagcctggag cccgaggact tcgccatgta ctactgccag cagcacaaca     1980

agtaccccta caccttcggc ggcggcacca agctggagat caagggaggg gggggatccg     2040

ggggaggagg ctccggcgga ggcggaagcc aggtgcagct gcagcagccc ggcgccgagc     2100

tggtgagacc cggcgccagc gtgaagctga gctgcaaggc cagcggctac accttcacca     2160

gctactggat gaactgggtg aagcagagac ccgaccaggg cctggagtgg atcggcagaa     2220

tcgaccccta cgacagcgag acccactaca accagaagtt caaggacaag gccatcctga     2280

ccgtggacaa gagcagcagc accgcctaca tgcagctgag cagcctgacc agcgaggaca     2340

gcgccgtgta ctactgcgcc agaggcaact gggacgacta ctggggccag ggcaccaccc     2400

tgaccgtgag cagcaccacg acgccagcgc cgcgaccacc aacaccggcg cccaccatcg     2460

cgtcgcagcc cctgtccctg cgcccagagg cgtgccggcc agcggcgggg ggcgcagtgc     2520

acacgagggg gctggacttc gcctgtgata tctacatctg ggcgcccttg gccgggactt     2580

gtggggtcct tctcctgtca ctggttatca ccctttactg caggagtaag aggagcaggc     2640

tcctgcacag tgactacatg aacatgactc cccgccgccc cgggcccacc cgcaagcatt     2700

accagcccta tgccccacca cgcgacttcg cagcctatcg ctccaaacgg ggcagaaaga     2760

aactcctgta tatattcaaa caaccattta tgagaccagt acaaactact caagaggaag     2820

atggctgtag ctgccgattt ccagaagaag aagaaggagg atgtgaactg agagtgaagt     2880

tcagcaggag cgcagacgcc cccgcgtaca agcagggcca gaaccagctc tataacgagc     2940

tcaatctagg acgaagagag gagtacgatg ttttggacaa gagacgtggc cgggaccctg     3000

agatgggggg aaagccgaga aggaagaacc ctcaggaagg cctgtacaat gaactgcaga     3060

aagataagat ggcggaggcc tacagtgaga ttgggatgaa aggcgagcgc cggaggggca     3120

aggggcacga tggcctttac cagggtctca gtacagccac caaggacacc tacgacgccc     3180

ttcacatgca ggccctgccc cctcgctaag tttaaac                              3217


<210>  11
<211>  985
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  11

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gln Ile Val Leu Thr Gln Ser Pro Ala Ile Met 
            20                  25                  30          


Ser Ala Ser Pro Gly Glu Lys Val Thr Ile Thr Cys Ser Ala Ser Ser 
        35                  40                  45              


Ser Ile Ser Tyr Met His Trp Phe Gln Gln Lys Pro Gly Thr Ser Pro 
    50                  55                  60                  


Lys Leu Trp Ile Tyr Thr Thr Ser Asn Leu Ala Ser Gly Val Pro Ala 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser 
                85                  90                  95      


Arg Met Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys His Gln Arg Ser 
            100                 105                 110         


Thr Tyr Pro Leu Thr Phe Gly Ser Gly Thr Lys Leu Glu Leu Lys Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val 
    130                 135                 140                 


Gln Leu Gln Gln Ser Gly Ala Glu Leu Ala Lys Pro Gly Ala Ser Val 
145                 150                 155                 160 


Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr Arg Met 
                165                 170                 175     


His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile Gly Tyr 
            180                 185                 190         


Ile Asn Pro Ser Thr Gly Tyr Thr Glu Tyr Asn Gln Lys Phe Lys Asp 
        195                 200                 205             


Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr Met Gln 
    210                 215                 220                 


Leu Ser Ser Leu Thr Phe Glu Asp Ser Ala Val Tyr Tyr Cys Ala Arg 
225                 230                 235                 240 


Gly Gly Gly Val Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val 
                245                 250                 255     


Ser Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr 
            260                 265                 270         


Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala 
        275                 280                 285             


Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile 
    290                 295                 300                 


Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser 
305                 310                 315                 320 


Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr 
                325                 330                 335     


Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu 
            340                 345                 350         


Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu 
        355                 360                 365             


Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln 
    370                 375                 380                 


Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu 
385                 390                 395                 400 


Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly 
                405                 410                 415     


Lys Pro Gln Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu 
            420                 425                 430         


Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly 
        435                 440                 445             


Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser 
    450                 455                 460                 


Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro 
465                 470                 475                 480 


Pro Arg Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly 
                485                 490                 495     


Asp Val Glu Glu Asn Pro Gly Pro Met Ala Leu Pro Val Thr Ala Leu 
            500                 505                 510         


Leu Leu Pro Leu Ala Leu Leu Leu His Ala Ala Arg Pro Asp Val Gln 
        515                 520                 525             


Ile Thr Gln Ser Pro Ser Tyr Leu Ala Ala Ser Pro Gly Glu Thr Ile 
    530                 535                 540                 


Thr Ile Asn Cys Arg Ala Ser Lys Ser Ile Ser Lys Asp Leu Ala Trp 
545                 550                 555                 560 


Tyr Gln Glu Lys Pro Gly Lys Thr Asn Lys Leu Leu Ile Tyr Ser Gly 
                565                 570                 575     


Ser Thr Leu Gln Ser Gly Ile Pro Ser Arg Phe Ser Gly Ser Gly Ser 
            580                 585                 590         


Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro Glu Asp Phe 
        595                 600                 605             


Ala Met Tyr Tyr Cys Gln Gln His Asn Lys Tyr Pro Tyr Thr Phe Gly 
    610                 615                 620                 


Gly Gly Thr Lys Leu Glu Ile Lys Gly Gly Gly Gly Ser Gly Gly Gly 
625                 630                 635                 640 


Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Gln Gln Pro Gly Ala 
                645                 650                 655     


Glu Leu Val Arg Pro Gly Ala Ser Val Lys Leu Ser Cys Lys Ala Ser 
            660                 665                 670         


Gly Tyr Thr Phe Thr Ser Tyr Trp Met Asn Trp Val Lys Gln Arg Pro 
        675                 680                 685             


Asp Gln Gly Leu Glu Trp Ile Gly Arg Ile Asp Pro Tyr Asp Ser Glu 
    690                 695                 700                 


Thr His Tyr Asn Gln Lys Phe Lys Asp Lys Ala Ile Leu Thr Val Asp 
705                 710                 715                 720 


Lys Ser Ser Ser Thr Ala Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu 
                725                 730                 735     


Asp Ser Ala Val Tyr Tyr Cys Ala Arg Gly Asn Trp Asp Asp Tyr Trp 
            740                 745                 750         


Gly Gln Gly Thr Thr Leu Thr Val Ser Ser Thr Thr Thr Pro Ala Pro 
        755                 760                 765             


Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu 
    770                 775                 780                 


Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg 
785                 790                 795                 800 


Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly 
                805                 810                 815     


Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Arg 
            820                 825                 830         


Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro 
        835                 840                 845             


Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro 
    850                 855                 860                 


Arg Asp Phe Ala Ala Tyr Arg Ser Arg Val Lys Phe Ser Arg Ser Ala 
865                 870                 875                 880 


Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu 
                885                 890                 895     


Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly 
            900                 905                 910         


Arg Asp Pro Glu Met Gly Gly Lys Pro Gln Arg Arg Lys Asn Pro Gln 
        915                 920                 925             


Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr 
    930                 935                 940                 


Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp 
945                 950                 955                 960 


Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala 
                965                 970                 975     


Leu His Met Gln Ala Leu Pro Pro Arg 
            980                 985 


<210>  12
<211>  2974
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  12
gcgatcgcat ggccttacca gtgaccgcct tgctcctgcc gctggccttg ctgctccacg       60

ccgccaggcc gcagatcgtg ctgacccaga gccccgccat catgagcgcc agccccggcg      120

agaaggtgac catcacctgc agcgccagca gcagcatcag ctacatgcac tggttccagc      180

agaagcccgg caccagcccc aagctgtgga tctacaccac cagcaacctg gccagcggcg      240

tgcccgccag attcagcggc agcggcagcg gcaccagcta cagcctgacc atcagcagaa      300

tggaggccga ggacgccgcc acctactact gccaccagag aagcacctac cccctgacct      360

tcggcagcgg caccaagctg gagctgaagg gagggggggg atccggggga ggaggctccg      420

gcggaggcgg aagccaggtg cagctgcagc agagcggcgc cgagctggcc aagcccggcg      480

ccagcgtgaa gatgagctgc aaggccagcg gctacacctt caccagctac agaatgcact      540

gggtgaagca gagacccggc cagggcctgg agtggatcgg ctacatcaac cccagcaccg      600

gctacaccga gtacaaccag aagttcaagg acaaggccac cctgaccgcc gacaagagca      660

gcagcaccgc ctacatgcag ctgagcagcc tgaccttcga ggacagcgcc gtgtactact      720

gcgccagagg cggcggcgtg ttcgactact ggggccaggg caccaccctg accgtgagca      780

gcaccacgac gccagcgccg cgaccaccaa caccggcgcc caccatcgcg tcgcagcccc      840

tgtccctgcg cccagaggcg tgccggccag cggcgggggg cgcagtgcac acgagggggc      900

tggacttcgc ctgtgatatc tacatctggg cgcccttggc cgggacttgt ggggtccttc      960

tcctgtcact ggttatcacc ctttactgca aacggggcag aaagaaactc ctgtatatat     1020

tcaaacaacc atttatgaga ccagtacaaa ctactcaaga ggaagatggc tgtagctgcc     1080

gatttccaga agaagaagaa ggaggatgtg aactgagagt gaagttcagc aggagcgcag     1140

acgcccccgc gtaccagcag ggccagaacc agctctataa cgagctcaat ctaggacgaa     1200

gagaggagta cgatgttttg gacaagagac gtggccggga ccctgagatg gggggaaagc     1260

cgcagagaag gaagaaccct caggaaggcc tgtacaatga actgcagaaa gataagatgg     1320

cggaggccta cagtgagatt gggatgaaag gcgagcgccg gaggggcaag gggcacgatg     1380

gcctttacca gggtctcagt acagccacca aggacaccta cgacgccctt cacatgcagg     1440

ccctgccccc tcgcggaagc ggagctacta acttcagcct gctgaagcag gctggagacg     1500

tggaggagaa ccctggacct atggccttac cagtgaccgc cttgctcctg ccgctggcct     1560

tgctgctcca cgccgccagg ccggacgtgc agatcaccca gagccccagc tacctggccg     1620

ccagccccgg cgagaccatc accatcaact gcagagccag caagagcatc agcaaggacc     1680

tggcctggta ccaggagaag cccggcaaga ccaacaagct gctgatctac agcggcagca     1740

ccctgcagag cggcatcccc agcagattca gcggcagcgg cagcggcacc gacttcaccc     1800

tgaccatcag cagcctggag cccgaggact tcgccatgta ctactgccag cagcacaaca     1860

agtaccccta caccttcggc ggcggcacca agctggagat caagggaggg gggggatccg     1920

ggggaggagg ctccggcgga ggcggaagcc aggtgcagct gcagcagccc ggcgccgagc     1980

tggtgagacc cggcgccagc gtgaagctga gctgcaaggc cagcggctac accttcacca     2040

gctactggat gaactgggtg aagcagagac ccgaccaggg cctggagtgg atcggcagaa     2100

tcgaccccta cgacagcgag acccactaca accagaagtt caaggacaag gccatcctga     2160

ccgtggacaa gagcagcagc accgcctaca tgcagctgag cagcctgacc agcgaggaca     2220

gcgccgtgta ctactgcgcc agaggcaact gggacgacta ctggggccag ggcaccaccc     2280

tgaccgtgag cagcaccacg acgccagcgc cgcgaccacc aacaccggcg cccaccatcg     2340

cgtcgcagcc cctgtccctg cgcccagagg cgtgccggcc agcggcgggg ggcgcagtgc     2400

acacgagggg gctggacttc gcctgtgata tctacatctg ggcgcccttg gccgggactt     2460

gtggggtcct tctcctgtca ctggttatca ccctttactg caggagtaag aggagcaggc     2520

tcctgcacag tgactacatg aacatgactc cccgccgccc cgggcccacc cgcaagcatt     2580

accagcccta tgccccacca cgcgacttcg cagcctatcg ctccagagtg aagttcagca     2640

ggagcgcaga cgcccccgcg taccagcagg gccagaacca gctctataac gagctcaatc     2700

taggacgaag agaggagtac gatgttttgg acaagagacg tggccgggac cctgagatgg     2760

ggggaaagcc gcagagaagg aagaaccctc aggaaggcct gtacaatgaa ctgcagaaag     2820

ataagatggc ggaggcctac agtgagattg ggatgaaagg cgagcgccgg aggggcaagg     2880

ggcacgatgg cctttaccag ggtctcagta cagccaccaa ggacacctac gacgcccttc     2940

acatgcaggc cctgccccct cgctaagttt aaac                                 2974


<210>  13
<211>  546
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  13

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Ser Asp Ile Val Leu Thr Gln Ser Pro Ala Ser 
            20                  25                  30          


Leu Ala Val Ser Leu Gly Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser 
        35                  40                  45              


Lys Ser Val Ser Thr Ser Gly Tyr Ser Tyr Leu His Trp Tyr Gln Gln 
    50                  55                  60                  


Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile Tyr Leu Ala Ser Asn Leu 
65                  70                  75                  80  


Glu Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp 
                85                  90                  95      


Phe Thr Leu Asn Ile His Pro Val Glu Glu Glu Asp Ala Ala Thr Tyr 
            100                 105                 110         


Tyr Cys Gln His Ser Arg Glu Leu Pro Phe Thr Phe Gly Ser Gly Thr 
        115                 120                 125             


Lys Leu Glu Ile Lys Lys Ile Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
145                 150                 155                 160 


Ser Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly 
                165                 170                 175     


Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Asp Phe Ser Arg 
            180                 185                 190         


Tyr Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 
        195                 200                 205             


Ile Gly Glu Ile Asn Pro Thr Ser Ser Thr Ile Asn Phe Thr Pro Ser 
    210                 215                 220                 


Leu Lys Asp Lys Val Phe Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu 
225                 230                 235                 240 


Tyr Leu Gln Met Ser Lys Val Arg Ser Glu Asp Thr Ala Leu Tyr Tyr 
                245                 250                 255     


Cys Ala Arg Gly Asn Tyr Tyr Arg Tyr Gly Asp Ala Met Asp Tyr Trp 
            260                 265                 270         


Gly Gln Gly Thr Ser Val Thr Val Ser Thr Thr Thr Pro Ala Pro Arg 
        275                 280                 285             


Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg 
    290                 295                 300                 


Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly 
305                 310                 315                 320 


Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr 
                325                 330                 335     


Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Arg Ser 
            340                 345                 350         


Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg 
        355                 360                 365             


Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg 
    370                 375                 380                 


Asp Phe Ala Ala Tyr Arg Ser Lys Arg Gly Arg Lys Lys Leu Leu Tyr 
385                 390                 395                 400 


Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu 
                405                 410                 415     


Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu 
            420                 425                 430         


Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln 
        435                 440                 445             


Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu 
    450                 455                 460                 


Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly 
465                 470                 475                 480 


Lys Pro Gln Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu 
                485                 490                 495     


Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly 
            500                 505                 510         


Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser 
        515                 520                 525             


Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro 
    530                 535                 540                 


Pro Arg 
545     


<210>  14
<211>  1657
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  14
gcgatcgcat ggccttacca gtgaccgcct tgctcctgcc gctggccttg ctgctccacg       60

ccgccaggcc gagcgacatc gtgctgaccc agagccccgc cagcctggcc gtgagcctgg      120

gccagagagc caccatcagc tgcagagcca gcaagagcgt gagcaccagc ggctacagct      180

acctgcactg gtaccagcag aagcccggcc agccccccaa gctgctgatc tacctggcca      240

gcaacctgga gagcggcgtg cccgccagat tcagcggcag cggcagcggc accgacttca      300

ccctgaacat ccaccccgtg gaggaggagg acgccgccac ctactactgc cagcacagca      360

gagagctgcc cttcaccttc ggcagcggca ccaagctgga gatcaagaag atcagcggcg      420

gcggcggcag cggcggcggc ggcagcggcg gcggcggcag cggcggcggc ggcagcggcg      480

gcggcggcag ccaggtgcag ctggtggaga gcggcggcgg cctggtgcag cccggcggca      540

gcctgaagct gagctgcgcc gccagcggct tcgacttcag cagatactgg atgagctggg      600

tgagacaggc ccccggcaag ggcctggagt ggatcggcga gatcaacccc accagcagca      660

ccatcaactt cacccccagc ctgaaggaca aggtgttcat cagcagagac aacgccaaga      720

acaccctgta cctgcagatg agcaaggtga gaagcgagga caccgccctg tactactgcg      780

ccagaggcaa ctactacaga tacggcgacg ccatggacta ctggggccag ggcaccagcg      840

tgaccgtgag caccacgacg ccagcgccgc gaccaccaac accggcgccc accatcgcgt      900

cgcagcccct gtccctgcgc ccagaggcgt gccggccagc ggcggggggc gcagtgcaca      960

cgagggggct ggacttcgcc tgtgatatct acatctgggc gcccttggcc gggacttgtg     1020

gggtccttct cctgtcactg gttatcaccc tttactgcag gagtaagagg agcaggctcc     1080

tgcacagtga ctacatgaac atgactcccc gccgccccgg gcccacccgc aagcattacc     1140

agccctatgc cccaccacgc gacttcgcag cctatcgctc caaacggggc agaaagaaac     1200

tcctgtatat attcaaacaa ccatttatga gaccagtaca aactactcaa gaggaagatg     1260

gctgtagctg ccgatttcca gaagaagaag aaggaggatg tgaactgaga gtgaagttca     1320

gcaggagcgc agacgccccc gcgtaccagc agggccagaa ccagctctat aacgagctca     1380

atctaggacg aagagaggag tacgatgttt tggacaagag acgtggccgg gaccctgaga     1440

tggggggaaa gccgcagaga aggaagaacc ctcaggaagg cctgtacaat gaactgcaga     1500

aagataagat ggcggaggcc tacagtgaga ttgggatgaa aggcgagcgc cggaggggca     1560

aggggcacga tggcctttac cagggtctca gtacagccac caaggacacc tacgacgccc     1620

ttcacatgca ggccctgccc cctcgctaag tttaaac                              1657


<210>  15
<211>  490
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  15

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu 
            20                  25                  30          


Ala Val Ser Leu Gly Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Lys 
        35                  40                  45              


Ser Val Ser Thr Ser Gly Tyr Ser Tyr Leu His Trp Tyr Gln Gln Lys 
    50                  55                  60                  


Pro Gly Gln Pro Pro Lys Leu Leu Ile Tyr Leu Ala Ser Asn Leu Glu 
65                  70                  75                  80  


Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 
                85                  90                  95      


Thr Leu Asn Ile His Pro Val Glu Glu Glu Asp Ala Ala Thr Tyr Tyr 
            100                 105                 110         


Cys Gln His Ser Arg Glu Leu Pro Phe Thr Phe Gly Ser Gly Thr Lys 
        115                 120                 125             


Leu Glu Ile Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln 
145                 150                 155                 160 


Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Asp Phe 
                165                 170                 175     


Ser Arg Tyr Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
            180                 185                 190         


Glu Trp Ile Gly Glu Ile Asn Pro Thr Ser Ser Thr Ile Asn Phe Thr 
        195                 200                 205             


Pro Ser Leu Lys Asp Lys Val Phe Ile Ser Arg Asp Asn Ala Lys Asn 
    210                 215                 220                 


Thr Leu Tyr Leu Gln Met Ser Lys Val Arg Ser Glu Asp Thr Ala Leu 
225                 230                 235                 240 


Tyr Tyr Cys Ala Arg Gly Asn Tyr Tyr Arg Tyr Gly Asp Ala Met Asp 
                245                 250                 255     


Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Thr Thr Thr Pro Ala 
            260                 265                 270         


Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser 
        275                 280                 285             


Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr 
    290                 295                 300                 


Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala 
305                 310                 315                 320 


Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys 
                325                 330                 335     


Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr 
            340                 345                 350         


Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro 
        355                 360                 365             


Pro Arg Asp Phe Ala Ala Tyr Arg Ser Arg Val Lys Phe Ser Arg Ser 
    370                 375                 380                 


Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu 
385                 390                 395                 400 


Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg 
                405                 410                 415     


Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Gln Arg Arg Lys Asn Pro 
            420                 425                 430         


Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala 
        435                 440                 445             


Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His 
    450                 455                 460                 


Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp 
465                 470                 475                 480 


Ala Leu His Met Gln Ala Leu Pro Pro Arg 
                485                 490 


<210>  16
<211>  1489
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  16
gcgatcgcat ggccttacca gtgaccgcct tgctcctgcc gctggccttg ctgctccacg       60

ccgccaggcc ggacatcgtg ctgacccaga gccccgccag cctggccgtg agcctgggcc      120

agagggccac catcagctgc agggccagca agagcgtgag caccagcggc tacagctacc      180

tgcactggta ccagcagaag cccggccagc cccccaagct gctgatctac ctggccagca      240

acctggagag cggcgtgccc gccaggttca gcggcagcgg cagcggcacc gacttcaccc      300

tgaacatcca ccccgtggag gaggaggacg ccgccaccta ctactgccag cacagcaggg      360

agctgccctt caccttcggc agcggcacca agctggagat caagggaggg gggggatccg      420

ggggaggagg ctccggcgga ggcggaagcc aggtgcagct ggtggagagc ggcggcggcc      480

tggtgcagcc cggcggcagc ctgaagctga gctgcgccgc cagcggcttc gacttcagca      540

ggtactggat gagctgggtg aggcaggccc ccggcaaggg cctggagtgg atcggcgaga      600

tcaaccccac cagcagcacc atcaacttca cccccagcct gaaggacaag gtgttcatca      660

gcagggacaa cgccaagaac accctgtacc tgcagatgag caaggtgagg agcgaggaca      720

ccgccctgta ctactgcgcc aggggcaact actacaggta cggcgacgcc atggactact      780

ggggccaggg caccagcgtg accgtgagca ccacgacgcc agcgccgcga ccaccaacac      840

cggcgcccac catcgcgtcg cagcccctgt ccctgcgccc agaggcgtgc cggccagcgg      900

cggggggcgc agtgcacacg agggggctgg acttcgcctg tgatatctac atctgggcgc      960

ccttggccgg gacttgtggg gtccttctcc tgtcactggt tatcaccctt tactgcagga     1020

gtaagaggag caggctcctg cacagtgact acatgaacat gactccccgc cgccccgggc     1080

ccacccgcaa gcattaccag ccctatgccc caccacgcga cttcgcagcc tatcgctcca     1140

gagtgaagtt cagcaggagc gcagacgccc ccgcgtacca gcagggccag aaccagctct     1200

ataacgagct caatctagga cgaagagagg agtacgatgt tttggacaag agacgtggcc     1260

gggaccctga gatgggggga aagccgcaga gaaggaagaa ccctcaggaa ggcctgtaca     1320

atgaactgca gaaagataag atggcggagg cctacagtga gattgggatg aaaggcgagc     1380

gccggagggg caaggggcac gatggccttt accagggtct cagtacagcc accaaggaca     1440

cctacgacgc ccttcacatg caggccctgc cccctcgcta agtttaaac                 1489


<210>  17
<211>  491
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  17

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu 
            20                  25                  30          


Ala Val Ser Leu Gly Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Lys 
        35                  40                  45              


Ser Val Ser Thr Ser Gly Tyr Ser Tyr Leu His Trp Tyr Gln Gln Lys 
    50                  55                  60                  


Pro Gly Gln Pro Pro Lys Leu Leu Ile Tyr Leu Ala Ser Asn Leu Glu 
65                  70                  75                  80  


Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 
                85                  90                  95      


Thr Leu Asn Ile His Pro Val Glu Glu Glu Asp Ala Ala Thr Tyr Tyr 
            100                 105                 110         


Cys Gln His Ser Arg Glu Leu Pro Phe Thr Phe Gly Ser Gly Thr Lys 
        115                 120                 125             


Leu Glu Ile Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln 
145                 150                 155                 160 


Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Asp Phe 
                165                 170                 175     


Ser Arg Tyr Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
            180                 185                 190         


Glu Trp Ile Gly Glu Ile Asn Pro Thr Ser Ser Thr Ile Asn Phe Thr 
        195                 200                 205             


Pro Ser Leu Lys Asp Lys Val Phe Ile Ser Arg Asp Asn Ala Lys Asn 
    210                 215                 220                 


Thr Leu Tyr Leu Gln Met Ser Lys Val Arg Ser Glu Asp Thr Ala Leu 
225                 230                 235                 240 


Tyr Tyr Cys Ala Arg Gly Asn Tyr Tyr Arg Tyr Gly Asp Ala Met Asp 
                245                 250                 255     


Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Thr Thr Thr Pro Ala 
            260                 265                 270         


Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser 
        275                 280                 285             


Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr 
    290                 295                 300                 


Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala 
305                 310                 315                 320 


Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys 
                325                 330                 335     


Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met 
            340                 345                 350         


Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe 
        355                 360                 365             


Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg 
    370                 375                 380                 


Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn 
385                 390                 395                 400 


Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg 
                405                 410                 415     


Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Gln Arg Arg Lys Asn 
            420                 425                 430         


Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu 
        435                 440                 445             


Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly 
    450                 455                 460                 


His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr 
465                 470                 475                 480 


Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
                485                 490     


<210>  18
<211>  1492
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  18
gcgatcgcat ggccttacca gtgaccgcct tgctcctgcc gctggccttg ctgctccacg       60

ccgccaggcc ggacatcgtg ctgacccaga gccccgccag cctggccgtg agcctgggcc      120

agagggccac catcagctgc agggccagca agagcgtgag caccagcggc tacagctacc      180

tgcactggta ccagcagaag cccggccagc cccccaagct gctgatctac ctggccagca      240

acctggagag cggcgtgccc gccaggttca gcggcagcgg cagcggcacc gacttcaccc      300

tgaacatcca ccccgtggag gaggaggacg ccgccaccta ctactgccag cacagcaggg      360

agctgccctt caccttcggc agcggcacca agctggagat caagggaggg gggggatccg      420

ggggaggagg ctccggcgga ggcggaagcc aggtgcagct ggtggagagc ggcggcggcc      480

tggtgcagcc cggcggcagc ctgaagctga gctgcgccgc cagcggcttc gacttcagca      540

ggtactggat gagctgggtg aggcaggccc ccggcaaggg cctggagtgg atcggcgaga      600

tcaaccccac cagcagcacc atcaacttca cccccagcct gaaggacaag gtgttcatca      660

gcagggacaa cgccaagaac accctgtacc tgcagatgag caaggtgagg agcgaggaca      720

ccgccctgta ctactgcgcc aggggcaact actacaggta cggcgacgcc atggactact      780

ggggccaggg caccagcgtg accgtgagca ccacgacgcc agcgccgcga ccaccaacac      840

cggcgcccac catcgcgtcg cagcccctgt ccctgcgccc agaggcgtgc cggccagcgg      900

cggggggcgc agtgcacacg agggggctgg acttcgcctg tgatatctac atctgggcgc      960

ccttggccgg gacttgtggg gtccttctcc tgtcactggt tatcaccctt tactgcaaac     1020

ggggcagaaa gaaactcctg tatatattca aacaaccatt tatgagacca gtacaaacta     1080

ctcaagagga agatggctgt agctgccgat ttccagaaga agaagaagga ggatgtgaac     1140

tgagagtgaa gttcagcagg agcgcagacg cccccgcgta ccagcagggc cagaaccagc     1200

tctataacga gctcaatcta ggacgaagag aggagtacga tgttttggac aagagacgtg     1260

gccgggaccc tgagatgggg ggaaagccgc agagaaggaa gaaccctcag gaaggcctgt     1320

acaatgaact gcagaaagat aagatggcgg aggcctacag tgagattggg atgaaaggcg     1380

agcgccggag gggcaagggg cacgatggcc tttaccaggg tctcagtaca gccaccaagg     1440

acacctacga cgcccttcac atgcaggccc tgccccctcg ctaagtttaa ac             1492


<210>  19
<211>  997
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  19

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Asp Val Val Met Thr Gln Ser His Arg Phe Met 
            20                  25                  30          


Ser Thr Ser Val Gly Asp Arg Val Ser Ile Thr Cys Arg Ala Ser Gln 
        35                  40                  45              


Asp Val Asn Thr Ala Val Ser Trp Tyr Gln Gln Lys Pro Gly Gln Ser 
    50                  55                  60                  


Pro Lys Leu Leu Ile Phe Ser Ala Ser Tyr Arg Tyr Thr Gly Val Pro 
65                  70                  75                  80  


Asp Arg Phe Thr Gly Ser Gly Ser Gly Ala Asp Phe Thr Leu Thr Ile 
                85                  90                  95      


Ser Ser Val Gln Ala Glu Asp Leu Ala Val Tyr Tyr Cys Gln Gln His 
            100                 105                 110         


Tyr Ser Thr Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln 
    130                 135                 140                 


Ile Gln Leu Val Gln Ser Gly Pro Asp Leu Lys Lys Pro Gly Glu Thr 
145                 150                 155                 160 


Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Phe Gly 
                165                 170                 175     


Met Asn Trp Val Lys Gln Ala Pro Gly Lys Gly Phe Lys Trp Met Ala 
            180                 185                 190         


Trp Ile Asn Thr Thr Arg Tyr Thr Gly Glu Ser Tyr Phe Ala Asp Asp 
        195                 200                 205             


Phe Lys Gly Arg Phe Ala Phe Ser Val Glu Thr Ser Ala Thr Thr Ala 
    210                 215                 220                 


Tyr Leu Gln Ile Asn Asn Leu Lys Thr Glu Asp Thr Ala Thr Tyr Phe 
225                 230                 235                 240 


Cys Ala Arg Gly Glu Ile Tyr Tyr Gly Tyr Asp Gly Gly Phe Ala Tyr 
                245                 250                 255     


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ala Thr Thr Thr Pro Ala 
            260                 265                 270         


Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser 
        275                 280                 285             


Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr 
    290                 295                 300                 


Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala 
305                 310                 315                 320 


Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys 
                325                 330                 335     


Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met 
            340                 345                 350         


Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe 
        355                 360                 365             


Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg 
    370                 375                 380                 


Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn 
385                 390                 395                 400 


Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg 
                405                 410                 415     


Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Gln Arg Arg Lys Asn 
            420                 425                 430         


Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu 
        435                 440                 445             


Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly 
    450                 455                 460                 


His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr 
465                 470                 475                 480 


Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg Gly Ser Gly Ala Thr 
                485                 490                 495     


Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly 
            500                 505                 510         


Pro Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
        515                 520                 525             


His Ala Ala Arg Pro Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu 
    530                 535                 540                 


Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln 
545                 550                 555                 560 


Asp Val Gly Ile Ala Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Val 
                565                 570                 575     


Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg His Thr Gly Val Pro 
            580                 585                 590         


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile 
        595                 600                 605             


Ser Ser Leu Gln Pro Glu Asp Val Ala Thr Tyr Tyr Cys Gln Gln Tyr 
    610                 615                 620                 


Ser Ser Tyr Pro Tyr Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
625                 630                 635                 640 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu 
                645                 650                 655     


Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser 
            660                 665                 670         


Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asp Phe Ser Arg Tyr Trp 
        675                 680                 685             


Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Gly 
    690                 695                 700                 


Glu Ile Asn Pro Asp Ser Ser Thr Ile Asn Tyr Ala Pro Ser Leu Lys 
705                 710                 715                 720 


Asp Lys Phe Ile Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr Leu 
                725                 730                 735     


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
            740                 745                 750         


Arg Pro Asp Gly Asn Tyr Trp Tyr Phe Asp Val Trp Gly Gln Gly Thr 
        755                 760                 765             


Leu Val Thr Val Ser Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr 
    770                 775                 780                 


Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala 
785                 790                 795                 800 


Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe 
                805                 810                 815     


Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val 
            820                 825                 830         


Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Arg Ser Lys Arg Ser 
        835                 840                 845             


Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly 
    850                 855                 860                 


Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala 
865                 870                 875                 880 


Ala Tyr Arg Ser Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala 
                885                 890                 895     


Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg 
            900                 905                 910         


Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu 
        915                 920                 925             


Met Gly Gly Lys Pro Gln Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr 
    930                 935                 940                 


Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly 
945                 950                 955                 960 


Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln 
                965                 970                 975     


Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln 
            980                 985                 990         


Ala Leu Pro Pro Arg 
        995         


<210>  20
<211>  2994
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  20
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccggatgtgg tgatgaccca gagccatcgc tttatgagca ccagcgtggg cgatcgcgtg      120

agcattacct gccgcgcgag ccaggatgtg aacaccgcgg tgagctggta tcagcagaaa      180

ccgggccaga gcccgaaact gctgattttt agcgcgagct atcgctatac cggcgtgccg      240

gatcgcttta ccggcagcgg cagcggcgcg gattttaccc tgaccattag cagcgtgcag      300

gcggaagatc tggcggtgta ttattgccag cagcattata gcaccccgtg gacctttggc      360

ggcggcacca aactggaaat taaaggaggg gggggatccg ggggaggagg ctccggcgga      420

ggcggaagcc agattcagct ggtgcagagc ggcccggatc tgaaaaaacc gggcgaaacc      480

gtgaaactga gctgcaaagc gagcggctat acctttacca actttggcat gaactgggtg      540

aaacaggcgc cgggcaaagg ctttaaatgg atggcgtgga ttaacaccac ccgctatacc      600

ggcgaaagct attttgcgga tgattttaaa ggccgctttg cgtttagcgt ggaaaccagc      660

gcgaccaccg cgtatctgca gattaacaac ctgaaaaccg aagataccgc gacctatttt      720

tgcgcgcgcg gcgaaattta ttatggctat gatggcggct ttgcgtattg gggccagggc      780

accctggtga ccgtgagcgc gaccacgacg ccagcgccgc gaccaccaac accggcgccc      840

accatcgcgt cgcagcccct gtccctgcgc ccagaggcgt gccggccagc ggcggggggc      900

gcagtgcaca cgagggggct ggacttcgcc tgtgatatct acatctgggc gcccttggcc      960

gggacttgtg gggtccttct cctgtcactg gttatcaccc tttactgcaa acggggcaga     1020

aagaaactcc tgtatatatt caaacaacca tttatgagac cagtacaaac tactcaagag     1080

gaagatggct gtagctgccg atttccagaa gaagaagaag gaggatgtga actgagagtg     1140

aagttcagca ggagcgcaga cgcccccgcg taccagcagg gccagaacca gctctataac     1200

gagctcaatc taggacgaag agaggagtac gatgttttgg acaagagacg tggccgggac     1260

cctgagatgg ggggaaagcc gcagagaagg aagaaccctc aggaaggcct gtacaatgaa     1320

ctgcagaaag ataagatggc ggaggcctac agtgagattg ggatgaaagg cgagcgccgg     1380

aggggcaagg ggcacgatgg cctttaccag ggtctcagta cagccaccaa ggacacctac     1440

gacgcccttc acatgcaggc cctgccccct cgcggaagcg gagccaccaa cttcagcctg     1500

ctgaagcagg ccggcgacgt ggaggagaac cccggccccg ccttaccagt gaccgccttg     1560

ctcctgccgc tggccttgct gctccacgcc gccaggccgg atattcagat gacccagagc     1620

ccgagcagcc tgagcgcgag cgtgggcgat cgcgtgacca ttacctgcaa agcgagccag     1680

gatgtgggca ttgcggtggc gtggtatcag cagaaaccgg gcaaagtgcc gaaactgctg     1740

atttattggg cgagcacccg ccataccggc gtgccggatc gctttagcgg cagcggcagc     1800

ggcaccgatt ttaccctgac cattagcagc ctgcagccgg aagatgtggc gacctattat     1860

tgccagcagt atagcagcta tccgtatacc tttggccagg gcaccaaagt ggaaattaaa     1920

ggaggggggg gatccggggg aggaggctcc ggcggaggcg gaagcgaagt gcagctggtg     1980

gaaagcggcg gcggcctggt gcagccgggc ggcagcctgc gcctgagctg cgcggcgagc     2040

ggctttgatt ttagccgcta ttggatgagc tgggtgcgcc aggcgccggg caaaggcctg     2100

gaatggattg gcgaaattaa cccggatagc agcaccatta actatgcgcc gagcctgaaa     2160

gataaattta ttattagccg cgataacgcg aaaaacagcc tgtatctgca gatgaacagc     2220

ctgcgcgcgg aagataccgc ggtgtattat tgcgcgcgcc cggatggcaa ctattggtat     2280

tttgatgtgt ggggccaggg caccctggtg accgtgagca gcaccacgac gccagcgccg     2340

cgaccaccaa caccggcgcc caccatcgcg tcgcagcccc tgtccctgcg cccagaggcg     2400

tgccggccag cggcgggggg cgcagtgcac acgagggggc tggacttcgc ctgtgatatc     2460

tacatctggg cgcccttggc cgggacttgt ggggtccttc tcctgtcact ggttatcacc     2520

ctttactgca ggagtaagag gagcaggctc ctgcacagtg actacatgaa catgactccc     2580

cgccgccccg ggcccacccg caagcattac cagccctatg ccccaccacg cgacttcgca     2640

gcctatcgct ccagagtgaa gttcagcagg agcgcagacg cccccgcgta ccagcagggc     2700

cagaaccagc tctataacga gctcaatcta ggacgaagag aggagtacga tgttttggac     2760

aagagacgtg gccgggaccc tgagatgggg ggaaagccgc agagaaggaa gaaccctcag     2820

gaaggcctgt acaatgaact gcagaaagat aagatggcgg aggcctacag tgagattggg     2880

atgaaaggcg agcgccggag gggcaagggg cacgatggcc tttaccaggg tctcagtaca     2940

gccaccaagg acacctacga cgcccttcac atgcaggccc tgccccctcg ctaa           2994


<210>  21
<211>  997
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  21

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Asp Val Val Met Thr Gln Ser His Arg Phe Met 
            20                  25                  30          


Ser Thr Ser Val Gly Asp Arg Val Ser Ile Thr Cys Arg Ala Ser Gln 
        35                  40                  45              


Asp Val Asn Thr Ala Val Ser Trp Tyr Gln Gln Lys Pro Gly Gln Ser 
    50                  55                  60                  


Pro Lys Leu Leu Ile Phe Ser Ala Ser Tyr Arg Tyr Thr Gly Val Pro 
65                  70                  75                  80  


Asp Arg Phe Thr Gly Ser Gly Ser Gly Ala Asp Phe Thr Leu Thr Ile 
                85                  90                  95      


Ser Ser Val Gln Ala Glu Asp Leu Ala Val Tyr Tyr Cys Gln Gln His 
            100                 105                 110         


Tyr Ser Thr Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Asp Ile Lys 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln 
    130                 135                 140                 


Ile Gln Leu Val Gln Ser Gly Pro Asp Leu Lys Lys Pro Gly Glu Thr 
145                 150                 155                 160 


Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Phe Gly 
                165                 170                 175     


Met Asn Trp Val Lys Gln Ala Pro Gly Lys Gly Phe Lys Trp Met Ala 
            180                 185                 190         


Trp Ile Asn Thr Tyr Thr Gly Glu Ser Tyr Phe Ala Asp Asp Phe Lys 
        195                 200                 205             


Gly Arg Phe Ala Phe Ser Val Glu Thr Ser Ala Thr Thr Ala Tyr Leu 
    210                 215                 220                 


Gln Ile Asn Asn Leu Lys Thr Glu Asp Thr Ala Thr Tyr Phe Cys Ala 
225                 230                 235                 240 


Arg Gly Glu Ile Tyr Tyr Gly Tyr Asp Gly Gly Phe Ala Tyr Trp Gly 
                245                 250                 255     


Gln Gly Thr Leu Val Thr Val Ser Ala Thr Thr Thr Pro Ala Pro Arg 
            260                 265                 270         


Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg 
        275                 280                 285             


Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly 
    290                 295                 300                 


Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr 
305                 310                 315                 320 


Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg 
                325                 330                 335     


Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro 
            340                 345                 350         


Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu 
        355                 360                 365             


Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala 
    370                 375                 380                 


Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu 
385                 390                 395                 400 


Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly 
                405                 410                 415     


Arg Asp Pro Glu Met Gly Gly Lys Pro Gln Arg Arg Lys Asn Pro Gln 
            420                 425                 430         


Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr 
        435                 440                 445             


Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp 
    450                 455                 460                 


Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala 
465                 470                 475                 480 


Leu His Met Gln Ala Leu Pro Pro Arg Gly Ser Gly Ala Thr Asn Phe 
                485                 490                 495     


Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met 
            500                 505                 510         


Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu His 
        515                 520                 525             


Ala Ala Arg Pro Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser 
    530                 535                 540                 


Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp 
545                 550                 555                 560 


Val Gly Ile Ala Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Val Pro 
                565                 570                 575     


Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg His Thr Gly Val Pro Asp 
            580                 585                 590         


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
        595                 600                 605             


Ser Leu Gln Pro Glu Asp Val Ala Thr Tyr Tyr Cys Gln Gln Tyr Ser 
    610                 615                 620                 


Ser Tyr Pro Tyr Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Gly 
625                 630                 635                 640 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val 
                645                 650                 655     


Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu 
            660                 665                 670         


Arg Leu Ser Cys Ala Ala Ser Gly Phe Asp Phe Ser Arg Tyr Trp Met 
        675                 680                 685             


Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Gly Glu 
    690                 695                 700                 


Ile Asn Pro Asp Ser Ser Thr Ile Asn Tyr Ala Pro Ser Leu Lys Asp 
705                 710                 715                 720 


Lys Phe Ile Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr Leu Gln 
                725                 730                 735     


Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            740                 745                 750         


Pro Asp Gly Asn Tyr Trp Tyr Phe Asp Val Trp Gly Gln Gly Thr Leu 
        755                 760                 765             


Val Thr Val Ser Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro 
    770                 775                 780                 


Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys 
785                 790                 795                 800 


Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala 
                805                 810                 815     


Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu 
            820                 825                 830         


Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys 
        835                 840                 845             


Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr 
    850                 855                 860                 


Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly 
865                 870                 875                 880 


Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala 
                885                 890                 895     


Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg 
            900                 905                 910         


Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu 
        915                 920                 925             


Met Gly Gly Lys Pro Gln Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr 
    930                 935                 940                 


Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly 
945                 950                 955                 960 


Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln 
                965                 970                 975     


Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln 
            980                 985                 990         


Ala Leu Pro Pro Arg 
        995         


<210>  22
<211>  3009
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  22
cgatcgcatg gccttaccag tgaccgcctt gctcctgccg ctggccttgc tgctccacgc       60

cgccaggccg gatgtggtga tgacccagag ccatcgcttt atgagcacca gcgtgggaga      120

tcgagtgagc attacctgcc gcgcgagcca ggatgtgaac accgcggtga gctggtatca      180

gcagaaaccg ggccagagcc cgaaactgct gatttttagc gcgagctatc gctataccgg      240

cgtgccggat cgctttaccg gcagcggcag cggcgcggat tttaccctga ccattagcag      300

cgtgcaggcg gaagatctgg cggtgtatta ttgccagcag cattatagca ccccgtggac      360

ctttggcggc ggcaccaaac tggatattaa aggagggggg ggatccgggg gaggaggctc      420

cggcggaggc ggaagccaga ttcagctggt gcagagcggc ccggatctga aaaaaccggg      480

cgaaaccgtg aaactgagct gcaaagcgag cggctatacc tttaccaact ttggcatgaa      540

ctgggtgaaa caggcgccgg gcaaaggctt taaatggatg gcgtggatta acacctatac      600

cggcgaaagc tattttgcgg atgattttaa aggccgcttt gcgtttagcg tggaaaccag      660

cgcgaccacc gcgtatctgc agattaacaa cctgaaaacc gaagataccg cgacctattt      720

ttgcgcgcgc ggcgaaattt attatggcta tgatggcggc tttgcgtatt ggggccaggg      780

caccctggtg accgtgagcg cgaccacgac gccagcgccg cgaccaccaa caccggcgcc      840

caccatcgcg tcgcagcccc tgtccctgcg cccagaggcg tgccggccag cggcgggggg      900

cgcagtgcac acgagggggc tggacttcgc ctgtgatatc tacatctggg cgcccttggc      960

cgggacttgt ggggtccttc tcctgtcact ggttatcacc ctttactgca aacggggcag     1020

aaagaaactc ctgtatatat tcaagcaacc atttatgaga ccagtacaaa ctactcaaga     1080

ggaagatggc tgtagctgcc gatttccaga agaagaagaa ggaggatgtg aactgagagt     1140

gaagttcagc aggagcgcag acgcccccgc gtaccagcag ggccagaacc agctctataa     1200

cgagctcaat ctaggacgaa gagaggagta cgatgttttg gacaagagac gtggccggga     1260

ccctgagatg gggggaaagc cgcagagaag gaagaaccct caggaaggcc tgtacaatga     1320

actgcagaaa gataagatgg cggaggccta cagtgagatt gggatgaaag gcgagcgccg     1380

gaggggcaag gggcacgatg gcctttacca gggtctcagt acagccacca aggacaccta     1440

cgacgccctt cacatgcagg ccctgccccc tcgcggaagc ggagccacca acttcagcct     1500

gctgaagcag gccggcgacg tggaggagaa ccccggcccc atggccttac cagtgaccgc     1560

cttgctcctg ccgctggcct tgctgctcca cgccgccagg ccggatattc agatgaccca     1620

gagcccgagc agcctgagcg cgagcgtggg cgaccgcgtg accattacct gcaaagcgag     1680

ccaggatgtg ggcattgcgg tggcgtggta tcagcagaaa ccgggcaaag tgccgaaact     1740

gctgatttat tgggcgagca cccgccatac cggcgtgccg gatcgcttta gcggcagcgg     1800

cagcggcacc gattttaccc tgaccattag cagcctgcag ccggaagatg tggcgaccta     1860

ttattgccag cagtatagca gctatccgta tacctttggc cagggcacca aagtggaaat     1920

taaaggaggg gggggatccg ggggaggagg ctccggcgga ggcggaagcg aagtgcagct     1980

ggtggaaagc ggcggcggcc tggtgcagcc gggcggcagc ctgcgcctga gctgcgcggc     2040

gagcggcttt gattttagcc gctattggat gagctgggtg cgccaggcgc cgggcaaagg     2100

cctggaatgg attggcgaaa ttaacccgga tagcagcacc attaactatg cgccgagcct     2160

gaaagataaa tttattatta gccgcgataa cgcgaaaaac agcctgtatc tgcagatgaa     2220

cagcctgcgc gcggaagata ccgcggtgta ttattgcgcg cgcccggatg gcaactattg     2280

gtattttgat gtgtggggcc agggcaccct ggtgaccgtg agcagcacca cgacgccagc     2340

gccgcgacca ccaacaccgg cgcccaccat cgcgtcgcag cccctgtccc tgcgcccaga     2400

ggcgtgccgg ccagcggcgg ggggcgcagt gcacacgagg gggctggact tcgcctgtga     2460

tatctacatc tgggcgccct tggccgggac ttgtggggtc cttctcctgt cactggttat     2520

caccctttac tgcaaacggg gcagaaagaa actcctgtat atattcaagc aaccatttat     2580

gagaccagta caaactactc aagaggaaga tggctgtagc tgccgatttc cagaagaaga     2640

agaaggagga tgtgaactga gagtgaagtt cagcaggagc gcagacgccc ccgcgtacca     2700

gcagggccag aaccagctct ataacgagct caatctagga cgaagagagg agtacgatgt     2760

tttggacaag agacgtggcc gggaccctga gatgggggga aagccgcaga gaaggaagaa     2820

ccctcaggaa ggcctgtaca atgaactgca gaaagataag atggcggagg cctacagtga     2880

gattgggatg aaaggcgagc gccggagggg caaggggcac gatggccttt accagggtct     2940

cagtacagcc accaaggaca cctacgacgc ccttcacatg caggccctgc cccctcgcta     3000

agtttaaac                                                             3009


<210>  23
<211>  423
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  23
agctagctgc agtaacgcca ttttgcaagg catggaaaaa taccaaacca agaatagaga       60

agttcagatc aagggcgggt acatgaaaat agctaacgtt gggccaaaca ggatatctgc      120

ggtgagcagt ttcggccccg gcccggggcc aagaacagat ggtcaccgca gtttcggccc      180

cggcccgagg ccaagaacag atggtcccca gatatggccc aaccctcagc agtttcttaa      240

gacccatcag atgtttccag gctcccccaa ggacctgaaa tgaccctgcg ccttatttga      300

attaaccaat cagcctgctt ctcgcttctg ttcgcgcgct tctgcttccc gagctctata      360

aaagagctca caacccctca ctcggcgcgc cagtcctccg acagactgag tcgcccgggt      420

acc                                                                    423


<210>  24
<211>  165
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  24

Met Ser Gly Leu Gly Arg Ser Arg Arg Gly Gly Arg Ser Arg Val Asp 
1               5                   10                  15      


Gln Glu Glu Arg Phe Pro Gln Gly Leu Trp Thr Gly Val Ala Met Arg 
            20                  25                  30          


Ser Cys Pro Glu Glu Gln Tyr Trp Asp Pro Leu Leu Gly Thr Cys Met 
        35                  40                  45              


Ser Cys Lys Thr Ile Cys Asn His Gln Ser Gln Arg Thr Cys Ala Ala 
    50                  55                  60                  


Phe Cys Arg Ser Leu Ser Cys Arg Lys Glu Gln Gly Lys Phe Tyr Asp 
65                  70                  75                  80  


His Leu Leu Arg Asp Cys Ile Ser Cys Ala Ser Ile Cys Gly Gln His 
                85                  90                  95      


Pro Lys Gln Cys Ala Tyr Phe Cys Glu Asn Lys Leu Arg Ser Pro Val 
            100                 105                 110         


Asn Leu Pro Pro Glu Leu Arg Arg Gln Arg Ser Gly Glu Val Glu Asn 
        115                 120                 125             


Asn Ser Asp Asn Ser Gly Arg Tyr Gln Gly Leu Glu His Arg Gly Ser 
    130                 135                 140                 


Glu Ala Ser Pro Ala Leu Pro Gly Leu Lys Leu Ser Ala Asp Gln Val 
145                 150                 155                 160 


Ala Leu Val Tyr Ser 
                165 


<210>  25
<211>  54
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  25

Met Leu Gln Met Ala Gly Gln Cys Ser Gln Asn Glu Tyr Phe Asp Ser 
1               5                   10                  15      


Leu Leu His Ala Cys Ile Pro Cys Gln Leu Arg Cys Ser Ser Asn Thr 
            20                  25                  30          


Pro Pro Leu Thr Cys Gln Arg Tyr Cys Asn Ala Ser Val Thr Asn Ser 
        35                  40                  45              


Val Lys Gly Thr Asn Ala 
    50                  


<210>  26
<211>  204
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  26

Ser Gly Pro Val Lys Glu Leu Val Gly Ser Val Gly Gly Ala Val Thr 
1               5                   10                  15      


Phe Pro Leu Lys Ser Lys Val Lys Gln Val Asp Ser Ile Val Trp Thr 
            20                  25                  30          


Phe Asn Thr Thr Pro Leu Val Thr Ile Gln Pro Glu Gly Gly Thr Ile 
        35                  40                  45              


Ile Val Thr Gln Asn Arg Asn Arg Glu Arg Val Asp Phe Pro Asp Gly 
    50                  55                  60                  


Gly Tyr Ser Leu Lys Leu Ser Lys Leu Lys Lys Asn Asp Ser Gly Ile 
65                  70                  75                  80  


Tyr Tyr Val Gly Ile Tyr Ser Ser Ser Leu Gln Gln Pro Ser Thr Gln 
                85                  90                  95      


Glu Tyr Val Leu His Val Tyr Glu His Leu Ser Lys Pro Lys Val Thr 
            100                 105                 110         


Met Gly Leu Gln Ser Asn Lys Asn Gly Thr Cys Val Thr Asn Leu Thr 
        115                 120                 125             


Cys Cys Met Glu His Gly Glu Glu Asp Val Ile Tyr Thr Trp Lys Ala 
    130                 135                 140                 


Leu Gly Gln Ala Ala Asn Glu Ser His Asn Gly Ser Ile Leu Pro Ile 
145                 150                 155                 160 


Ser Trp Arg Trp Gly Glu Ser Asp Met Thr Phe Ile Cys Val Ala Arg 
                165                 170                 175     


Asn Pro Val Ser Arg Asn Phe Ser Ser Pro Ile Leu Ala Arg Lys Leu 
            180                 185                 190         


Cys Glu Gly Ala Ala Asp Asp Pro Asp Ser Ser Met 
        195                 200                 


<210>  27
<211>  46
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  27

Met Asp Asp Ser Thr Glu Arg Glu Gln Ser Arg Leu Thr Ser Cys Leu 
1               5                   10                  15      


Lys Lys Arg Glu Glu Met Lys Leu Lys Glu Cys Val Ser Ile Leu Pro 
            20                  25                  30          


Arg Lys Glu Ser Pro Ser Val Arg Ser Ser Lys Asp Gly Lys 
        35                  40                  45      


<210>  28
<211>  242
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  28

Asp Pro Asn Phe Trp Leu Gln Val Gln Glu Ser Val Thr Val Gln Glu 
1               5                   10                  15      


Gly Leu Cys Val Leu Val Pro Cys Thr Phe Phe His Pro Ile Pro Tyr 
            20                  25                  30          


Tyr Asp Lys Asn Ser Pro Val His Gly Tyr Trp Phe Arg Glu Gly Ala 
        35                  40                  45              


Ile Ile Ser Arg Asp Ser Pro Val Ala Thr Asn Lys Leu Asp Gln Glu 
    50                  55                  60                  


Val Gln Glu Glu Thr Gln Gly Arg Phe Arg Leu Leu Gly Asp Pro Ser 
65                  70                  75                  80  


Arg Asn Asn Cys Ser Leu Ser Ile Val Asp Ala Arg Arg Arg Asp Asn 
                85                  90                  95      


Gly Ser Tyr Phe Phe Arg Met Glu Arg Gly Ser Thr Lys Tyr Ser Tyr 
            100                 105                 110         


Lys Ser Pro Gln Leu Ser Val His Val Thr Asp Leu Thr His Arg Pro 
        115                 120                 125             


Lys Ile Leu Ile Pro Gly Thr Leu Glu Pro Gly His Ser Lys Asn Leu 
    130                 135                 140                 


Thr Cys Ser Val Ser Trp Ala Cys Glu Gln Gly Thr Pro Pro Ile Phe 
145                 150                 155                 160 


Ser Trp Leu Ser Ala Ala Pro Thr Ser Leu Gly Pro Arg Thr Thr His 
                165                 170                 175     


Ser Ser Val Leu Ile Ile Thr Pro Arg Pro Gln Asp His Gly Thr Asn 
            180                 185                 190         


Leu Thr Cys Gln Val Lys Phe Ala Gly Ala Gly Val Thr Thr Glu Arg 
        195                 200                 205             


Thr Ile Gln Leu Asn Val Thr Tyr Val Pro Gln Asn Pro Thr Thr Gly 
    210                 215                 220                 


Ile Phe Pro Gly Asp Gly Ser Gly Lys Gln Glu Thr Arg Ala Gly Val 
225                 230                 235                 240 


Val His 
        


<210>  29
<211>  287
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  29

Thr Lys Glu Asp Pro Asn Pro Pro Ile Thr Asn Leu Arg Met Lys Ala 
1               5                   10                  15      


Lys Ala Gln Gln Leu Thr Trp Asp Leu Asn Arg Asn Val Thr Asp Ile 
            20                  25                  30          


Glu Cys Val Lys Asp Ala Asp Tyr Ser Met Pro Ala Val Asn Asn Ser 
        35                  40                  45              


Tyr Cys Gln Phe Gly Ala Ile Ser Leu Cys Glu Val Thr Asn Tyr Thr 
    50                  55                  60                  


Val Arg Val Ala Asn Pro Pro Phe Ser Thr Trp Ile Leu Phe Pro Glu 
65                  70                  75                  80  


Asn Ser Gly Lys Pro Trp Ala Gly Ala Glu Asn Leu Thr Cys Trp Ile 
                85                  90                  95      


His Asp Val Asp Phe Leu Ser Cys Ser Trp Ala Val Gly Pro Gly Ala 
            100                 105                 110         


Pro Ala Asp Val Gln Tyr Asp Leu Tyr Leu Asn Val Ala Asn Arg Arg 
        115                 120                 125             


Gln Gln Tyr Glu Cys Leu His Tyr Lys Thr Asp Ala Gln Gly Thr Arg 
    130                 135                 140                 


Ile Gly Cys Arg Phe Asp Asp Ile Ser Arg Leu Ser Ser Gly Ser Gln 
145                 150                 155                 160 


Ser Ser His Ile Leu Val Arg Gly Arg Ser Ala Ala Phe Gly Ile Pro 
                165                 170                 175     


Cys Thr Asp Lys Phe Val Val Phe Ser Gln Ile Glu Ile Leu Thr Pro 
            180                 185                 190         


Pro Asn Met Thr Ala Lys Cys Asn Lys Thr His Ser Phe Met His Trp 
        195                 200                 205             


Lys Met Arg Ser His Phe Asn Arg Lys Phe Arg Tyr Glu Leu Gln Ile 
    210                 215                 220                 


Gln Lys Arg Met Gln Pro Val Ile Thr Glu Gln Val Arg Asp Arg Thr 
225                 230                 235                 240 


Ser Phe Gln Leu Leu Asn Pro Gly Thr Tyr Thr Val Gln Ile Arg Ala 
                245                 250                 255     


Arg Glu Arg Val Tyr Glu Phe Leu Ser Ala Trp Ser Thr Pro Gln Arg 
            260                 265                 270         


Phe Glu Cys Asp Gln Glu Glu Gly Ala Asn Thr Arg Ala Trp Arg 
        275                 280                 285         


<210>  30
<211>  272
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  30

Pro Glu Glu Pro Leu Val Val Lys Val Glu Glu Gly Asp Asn Ala Val 
1               5                   10                  15      


Leu Gln Cys Leu Lys Gly Thr Ser Asp Gly Pro Thr Gln Gln Leu Thr 
            20                  25                  30          


Trp Ser Arg Glu Ser Pro Leu Lys Pro Phe Leu Lys Leu Ser Leu Gly 
        35                  40                  45              


Leu Pro Gly Leu Gly Ile His Met Arg Pro Leu Ala Ile Trp Leu Phe 
    50                  55                  60                  


Ile Phe Asn Val Ser Gln Gln Met Gly Gly Phe Tyr Leu Cys Gln Pro 
65                  70                  75                  80  


Gly Pro Pro Ser Glu Lys Ala Trp Gln Pro Gly Trp Thr Val Asn Val 
                85                  90                  95      


Glu Gly Ser Gly Glu Leu Phe Arg Trp Asn Val Ser Asp Leu Gly Gly 
            100                 105                 110         


Leu Gly Cys Gly Leu Lys Asn Arg Ser Ser Glu Gly Pro Ser Ser Pro 
        115                 120                 125             


Ser Gly Lys Leu Met Ser Pro Lys Leu Tyr Val Trp Ala Lys Asp Arg 
    130                 135                 140                 


Pro Glu Ile Trp Glu Gly Glu Pro Pro Cys Leu Pro Pro Arg Asp Ser 
145                 150                 155                 160 


Leu Asn Gln Ser Leu Ser Gln Asp Leu Thr Met Ala Pro Gly Ser Thr 
                165                 170                 175     


Leu Trp Leu Ser Cys Gly Val Pro Pro Asp Ser Val Ser Arg Gly Pro 
            180                 185                 190         


Leu Ser Trp Thr His Val His Pro Lys Gly Pro Lys Ser Leu Leu Ser 
        195                 200                 205             


Leu Glu Leu Lys Asp Asp Arg Pro Ala Arg Asp Met Trp Val Met Glu 
    210                 215                 220                 


Thr Gly Leu Leu Leu Pro Arg Ala Thr Ala Gln Asp Ala Gly Lys Tyr 
225                 230                 235                 240 


Tyr Cys His Arg Gly Asn Leu Thr Met Ser Phe His Leu Glu Ile Thr 
                245                 250                 255     


Ala Arg Pro Val Leu Trp His Trp Leu Leu Arg Thr Gly Gly Trp Lys 
            260                 265                 270         


<210>  31
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  31

Pro Ile Cys Val Thr Val 
1               5       


<210>  32
<211>  47
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  32

Lys Ile Ser His Phe Leu Lys Met Glu Ser Leu Asn Phe Ile Arg Ala 
1               5                   10                  15      


His Thr Pro Tyr Ile Asn Ile Tyr Asn Cys Glu Pro Ala Asn Pro Ser 
            20                  25                  30          


Glu Lys Asn Ser Pro Ser Thr Gln Tyr Cys Tyr Ser Ile Gln Ser 
        35                  40                  45          


<210>  33
<211>  480
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  33

Asp Ser Ser Lys Trp Val Phe Glu His Pro Glu Thr Leu Tyr Ala Trp 
1               5                   10                  15      


Glu Gly Ala Cys Val Trp Ile Pro Cys Thr Tyr Arg Ala Leu Asp Gly 
            20                  25                  30          


Asp Leu Glu Ser Phe Ile Leu Phe His Asn Pro Glu Tyr Asn Lys Asn 
        35                  40                  45              


Thr Ser Lys Phe Asp Gly Thr Arg Leu Tyr Glu Ser Thr Lys Asp Gly 
    50                  55                  60                  


Lys Val Pro Ser Glu Gln Lys Arg Val Gln Phe Leu Gly Asp Lys Asn 
65                  70                  75                  80  


Lys Asn Cys Thr Leu Ser Ile His Pro Val His Leu Asn Asp Ser Gly 
                85                  90                  95      


Gln Leu Gly Leu Arg Met Glu Ser Lys Thr Glu Lys Trp Met Glu Arg 
            100                 105                 110         


Ile His Leu Asn Val Ser Glu Arg Pro Phe Pro Pro His Ile Gln Leu 
        115                 120                 125             


Pro Pro Glu Ile Gln Glu Ser Gln Glu Val Thr Leu Thr Cys Leu Leu 
    130                 135                 140                 


Asn Phe Ser Cys Tyr Gly Tyr Pro Ile Gln Leu Gln Trp Leu Leu Glu 
145                 150                 155                 160 


Gly Val Pro Met Arg Gln Ala Ala Val Thr Ser Thr Ser Leu Thr Ile 
                165                 170                 175     


Lys Ser Val Phe Thr Arg Ser Glu Leu Lys Phe Ser Pro Gln Trp Ser 
            180                 185                 190         


His His Gly Lys Ile Val Thr Cys Gln Leu Gln Asp Ala Asp Gly Lys 
        195                 200                 205             


Phe Leu Ser Asn Asp Thr Val Gln Leu Asn Val Lys His Thr Pro Lys 
    210                 215                 220                 


Leu Glu Ile Lys Val Thr Pro Ser Asp Ala Ile Val Arg Glu Gly Asp 
225                 230                 235                 240 


Ser Val Thr Met Thr Cys Glu Val Ser Ser Ser Asn Pro Glu Tyr Thr 
                245                 250                 255     


Thr Val Ser Trp Leu Lys Asp Gly Thr Ser Leu Lys Lys Gln Asn Thr 
            260                 265                 270         


Phe Thr Leu Asn Leu Arg Glu Val Thr Lys Asp Gln Ser Gly Lys Tyr 
        275                 280                 285             


Cys Cys Gln Val Ser Asn Asp Val Gly Pro Gly Arg Ser Glu Glu Val 
    290                 295                 300                 


Phe Leu Gln Val Gln Tyr Ala Pro Glu Pro Ser Thr Val Gln Ile Leu 
305                 310                 315                 320 


His Ser Pro Ala Val Glu Gly Ser Gln Val Glu Phe Leu Cys Met Ser 
                325                 330                 335     


Leu Ala Asn Pro Leu Pro Thr Asn Tyr Thr Trp Tyr His Asn Gly Lys 
            340                 345                 350         


Glu Met Gln Gly Arg Thr Glu Glu Lys Val His Ile Pro Lys Ile Leu 
        355                 360                 365             


Pro Trp His Ala Gly Thr Tyr Ser Cys Val Ala Glu Asn Ile Leu Gly 
    370                 375                 380                 


Thr Gly Gln Arg Gly Pro Gly Ala Glu Leu Asp Val Gln Tyr Pro Pro 
385                 390                 395                 400 


Lys Lys Val Thr Thr Val Ile Gln Asn Pro Met Pro Ile Arg Glu Gly 
                405                 410                 415     


Asp Thr Val Thr Leu Ser Cys Asn Tyr Asn Ser Ser Asn Pro Ser Val 
            420                 425                 430         


Thr Arg Tyr Glu Trp Lys Pro His Gly Ala Trp Glu Glu Pro Ser Leu 
        435                 440                 445             


Gly Val Leu Lys Ile Gln Asn Val Gly Trp Asp Asn Thr Thr Ile Ala 
    450                 455                 460                 


Cys Ala Ala Cys Asn Ser Trp Cys Ser Trp Ala Ser Pro Val Ala Leu 
465                 470                 475                 480 


<210>  34
<211>  480
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  34

Gln Ser Pro Thr Pro Ser Pro Thr Gly Leu Thr Thr Ala Lys Met Pro 
1               5                   10                  15      


Ser Val Pro Leu Ser Ser Asp Pro Leu Pro Thr His Thr Thr Ala Phe 
            20                  25                  30          


Ser Pro Ala Ser Thr Phe Glu Arg Glu Asn Asp Phe Ser Glu Thr Thr 
        35                  40                  45              


Thr Ser Leu Ser Pro Asp Asn Thr Ser Thr Gln Val Ser Pro Asp Ser 
    50                  55                  60                  


Leu Asp Asn Ala Ser Ala Phe Asn Thr Thr Gly Val Ser Ser Val Gln 
65                  70                  75                  80  


Thr Pro His Leu Pro Thr His Ala Asp Ser Gln Thr Pro Ser Ala Gly 
                85                  90                  95      


Thr Asp Thr Gln Thr Phe Ser Gly Ser Ala Ala Asn Ala Lys Leu Asn 
            100                 105                 110         


Pro Thr Pro Gly Ser Asn Ala Ile Ser Asp Val Pro Gly Glu Arg Ser 
        115                 120                 125             


Thr Ala Ser Thr Phe Pro Thr Asp Pro Val Ser Pro Leu Thr Thr Thr 
    130                 135                 140                 


Leu Ser Leu Ala His His Ser Ser Ala Ala Leu Pro Ala Arg Thr Ser 
145                 150                 155                 160 


Asn Thr Thr Ile Thr Ala Asn Thr Ser Asp Ala Tyr Leu Asn Ala Ser 
                165                 170                 175     


Glu Thr Thr Thr Leu Ser Pro Ser Gly Ser Ala Val Ile Ser Thr Thr 
            180                 185                 190         


Thr Ile Ala Thr Thr Pro Ser Lys Pro Thr Cys Asp Glu Lys Tyr Ala 
        195                 200                 205             


Asn Ile Thr Val Asp Tyr Leu Tyr Asn Lys Glu Thr Lys Leu Phe Thr 
    210                 215                 220                 


Ala Lys Leu Asn Val Asn Glu Asn Val Glu Cys Gly Asn Asn Thr Cys 
225                 230                 235                 240 


Thr Asn Asn Glu Val His Asn Leu Thr Glu Cys Lys Asn Ala Ser Val 
                245                 250                 255     


Ser Ile Ser His Asn Ser Cys Thr Ala Pro Asp Lys Thr Leu Ile Leu 
            260                 265                 270         


Asp Val Pro Pro Gly Val Glu Lys Phe Gln Leu His Asp Cys Thr Gln 
        275                 280                 285             


Val Glu Lys Ala Asp Thr Thr Ile Cys Leu Lys Trp Lys Asn Ile Glu 
    290                 295                 300                 


Thr Phe Thr Cys Asp Thr Gln Asn Ile Thr Tyr Arg Phe Gln Cys Gly 
305                 310                 315                 320 


Asn Met Ile Phe Asp Asn Lys Glu Ile Lys Leu Glu Asn Leu Glu Pro 
                325                 330                 335     


Glu His Glu Tyr Lys Cys Asp Ser Glu Ile Leu Tyr Asn Asn His Lys 
            340                 345                 350         


Phe Thr Asn Ala Ser Lys Ile Ile Lys Thr Asp Phe Gly Ser Pro Gly 
        355                 360                 365             


Glu Pro Gln Ile Ile Phe Cys Arg Ser Glu Ala Ala His Gln Gly Val 
    370                 375                 380                 


Ile Thr Trp Asn Pro Pro Gln Arg Ser Phe His Asn Phe Thr Leu Cys 
385                 390                 395                 400 


Tyr Ile Lys Glu Thr Glu Lys Asp Cys Leu Asn Leu Asp Lys Asn Leu 
                405                 410                 415     


Ile Lys Tyr Asp Leu Gln Asn Leu Lys Pro Tyr Thr Lys Tyr Val Leu 
            420                 425                 430         


Ser Leu His Ala Tyr Ile Ile Ala Lys Val Gln Arg Asn Gly Ser Ala 
        435                 440                 445             


Ala Met Cys His Phe Thr Thr Lys Ser Ala Pro Pro Ser Gln Val Trp 
    450                 455                 460                 


Asn Met Thr Val Ser Met Thr Ser Asp Asn Ser Met His Val Lys Cys 
465                 470                 475                 480 


<210>  35
<211>  371
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  35

Lys Lys Val Val Leu Gly Lys Lys Gly Asp Thr Val Glu Leu Thr Cys 
1               5                   10                  15      


Thr Ala Ser Gln Lys Lys Ser Ile Gln Phe His Trp Lys Asn Ser Asn 
            20                  25                  30          


Gln Ile Lys Ile Leu Gly Asn Gln Gly Ser Phe Leu Thr Lys Gly Pro 
        35                  40                  45              


Ser Lys Leu Asn Asp Arg Ala Asp Ser Arg Arg Ser Leu Trp Asp Gln 
    50                  55                  60                  


Gly Asn Phe Pro Leu Ile Ile Lys Asn Leu Lys Ile Glu Asp Ser Asp 
65                  70                  75                  80  


Thr Tyr Ile Cys Glu Val Glu Asp Gln Lys Glu Glu Val Gln Leu Leu 
                85                  90                  95      


Val Phe Gly Leu Thr Ala Asn Ser Asp Thr His Leu Leu Gln Gly Gln 
            100                 105                 110         


Ser Leu Thr Leu Thr Leu Glu Ser Pro Pro Gly Ser Ser Pro Ser Val 
        115                 120                 125             


Gln Cys Arg Ser Pro Arg Gly Lys Asn Ile Gln Gly Gly Lys Thr Leu 
    130                 135                 140                 


Ser Val Ser Gln Leu Glu Leu Gln Asp Ser Gly Thr Trp Thr Cys Thr 
145                 150                 155                 160 


Val Leu Gln Asn Gln Lys Lys Val Glu Phe Lys Ile Asp Ile Val Val 
                165                 170                 175     


Leu Ala Phe Gln Lys Ala Ser Ser Ile Val Tyr Lys Lys Glu Gly Glu 
            180                 185                 190         


Gln Val Glu Phe Ser Phe Pro Leu Ala Phe Thr Val Glu Lys Leu Thr 
        195                 200                 205             


Gly Ser Gly Glu Leu Trp Trp Gln Ala Glu Arg Ala Ser Ser Ser Lys 
    210                 215                 220                 


Ser Trp Ile Thr Phe Asp Leu Lys Asn Lys Glu Val Ser Val Lys Arg 
225                 230                 235                 240 


Val Thr Gln Asp Pro Lys Leu Gln Met Gly Lys Lys Leu Pro Leu His 
                245                 250                 255     


Leu Thr Leu Pro Gln Ala Leu Pro Gln Tyr Ala Gly Ser Gly Asn Leu 
            260                 265                 270         


Thr Leu Ala Leu Glu Ala Lys Thr Gly Lys Leu His Gln Glu Val Asn 
        275                 280                 285             


Leu Val Val Met Arg Ala Thr Gln Leu Gln Lys Asn Leu Thr Cys Glu 
    290                 295                 300                 


Val Trp Gly Pro Thr Ser Pro Lys Leu Met Leu Ser Leu Lys Leu Glu 
305                 310                 315                 320 


Asn Lys Glu Ala Lys Val Ser Lys Arg Glu Lys Ala Val Trp Val Leu 
                325                 330                 335     


Asn Pro Glu Ala Gly Met Trp Gln Cys Leu Leu Ser Asp Ser Gly Gln 
            340                 345                 350         


Val Leu Leu Glu Ser Asn Ile Lys Val Leu Pro Thr Trp Ser Thr Pro 
        355                 360                 365             


Val Gln Pro 
    370     


<210>  36
<211>  219
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  36

Glu Leu Cys Asp Asp Asp Pro Pro Glu Ile Pro His Ala Thr Phe Lys 
1               5                   10                  15      


Ala Met Ala Tyr Lys Glu Gly Thr Met Leu Asn Cys Glu Cys Lys Arg 
            20                  25                  30          


Gly Phe Arg Arg Ile Lys Ser Gly Ser Leu Tyr Met Leu Cys Thr Gly 
        35                  40                  45              


Asn Ser Ser His Ser Ser Trp Asp Asn Gln Cys Gln Cys Thr Ser Ser 
    50                  55                  60                  


Ala Thr Arg Asn Thr Thr Lys Gln Val Thr Pro Gln Pro Glu Glu Gln 
65                  70                  75                  80  


Lys Glu Arg Lys Thr Thr Glu Met Gln Ser Pro Met Gln Pro Val Asp 
                85                  90                  95      


Gln Ala Ser Leu Pro Gly His Cys Arg Glu Pro Pro Pro Trp Glu Asn 
            100                 105                 110         


Glu Ala Thr Glu Arg Ile Tyr His Phe Val Val Gly Gln Met Val Tyr 
        115                 120                 125             


Tyr Gln Cys Val Gln Gly Tyr Arg Ala Leu His Arg Gly Pro Ala Glu 
    130                 135                 140                 


Ser Val Cys Lys Met Thr His Gly Lys Thr Arg Trp Thr Gln Pro Gln 
145                 150                 155                 160 


Leu Ile Cys Thr Gly Glu Met Glu Thr Ser Gln Phe Pro Gly Glu Glu 
                165                 170                 175     


Lys Pro Gln Ala Ser Pro Glu Gly Arg Pro Glu Ser Glu Thr Ser Cys 
            180                 185                 190         


Leu Val Thr Thr Thr Asp Phe Gln Ile Gln Thr Glu Met Ala Ala Thr 
        195                 200                 205             


Met Glu Thr Ser Ile Phe Thr Thr Glu Tyr Gln 
    210                 215                 


<210>  37
<211>  3799
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  37
gcgatcgcat ggccttacca gtgaccgcct tgctcctgcc gctggccttg ctgctccacg       60

ccgccaggcc gcagatcgtg ctgacccaga gccccgccat catgagcgcc agccccggcg      120

agaaggtgac catcacctgc agcgccagca gcagcatcag ctacatgcac tggttccagc      180

agaagcccgg caccagcccc aagctgtgga tctacaccac cagcaacctg gccagcggcg      240

tgcccgccag attcagcggc agcggcagcg gcaccagcta cagcctgacc atcagcagaa      300

tggaggccga ggacgccgcc acctactact gccaccagag aagcacctac cccctgacct      360

tcggcagcgg caccaagctg gagctgaagg gagggggggg atccggggga ggaggctccg      420

gcggaggcgg aagccaggtg cagctgcagc agagcggcgc cgagctggcc aagcccggcg      480

ccagcgtgaa gatgagctgc aaggccagcg gctacacctt caccagctac agaatgcact      540

gggtgaagca gagacccggc cagggcctgg agtggatcgg ctacatcaac cccagcaccg      600

gctacaccga gtacaaccag aagttcaagg acaaggccac cctgaccgcc gacaagagca      660

gcagcaccgc ctacatgcag ctgagcagcc tgaccttcga ggacagcgcc gtgtactact      720

gcgccagagg cggcggcgtg ttcgactact ggggccaggg caccaccctg accgtgagca      780

gcaccacgac gccagcgccg cgaccaccaa caccggcgcc caccatcgcg tcgcagcccc      840

tgtccctgcg cccagaggcg tgccggccag cggcgggggg cgcagtgcac acgagggggc      900

tggacttcgc ctgtgatatc tacatctggg cgcccttggc cgggacttgt ggggtccttc      960

tcctgtcact ggttatcacc ctttactgca aacggggcag aaagaaactc ctgtatatat     1020

tcaaacaacc atttatgaga ccagtacaaa ctactcaaga ggaagatggc tgtagctgcc     1080

gatttccaga agaagaagaa ggaggatgtg aactgagagt gaagttcagc aggagcgcag     1140

acgcccccgc gtaccagcag ggccagaacc agctctataa cgagctcaat ctaggacgaa     1200

gagaggagta cgatgttttg gacaagagac gtggccggga ccctgagatg gggggaaagc     1260

cgcagagaag gaagaaccct caggaaggcc tgtacaatga actgcagaaa gataagatgg     1320

cggaggccta cagtgagatt gggatgaaag gcgagcgccg gaggggcaag gggcacgatg     1380

gcctttacca gggtctcagt acagccacca aggacaccta cgacgccctt cacatgcagg     1440

ccctgccccc tcgcggaagc ggagctacta acttcagcct gctgaagcag gctggagacg     1500

tggaggagaa ccctggacct atggccttac cagtgaccgc cttgctcctg ccgctggcct     1560

tgctgctcca cgccgccagg ccggacgtgc agatcaccca gagccccagc tacctggccg     1620

ccagccccgg cgagaccatc accatcaact gcagagccag caagagcatc agcaaggacc     1680

tggcctggta ccaggagaag cccggcaaga ccaacaagct gctgatctac agcggcagca     1740

ccctgcagag cggcatcccc agcagattca gcggcagcgg cagcggcacc gacttcaccc     1800

tgaccatcag cagcctggag cccgaggact tcgccatgta ctactgccag cagcacaaca     1860

agtaccccta caccttcggc ggcggcacca agctggagat caagggaggg gggggatccg     1920

ggggaggagg ctccggcgga ggcggaagcc aggtgcagct gcagcagccc ggcgccgagc     1980

tggtgagacc cggcgccagc gtgaagctga gctgcaaggc cagcggctac accttcacca     2040

gctactggat gaactgggtg aagcagagac ccgaccaggg cctggagtgg atcggcagaa     2100

tcgaccccta cgacagcgag acccactaca accagaagtt caaggacaag gccatcctga     2160

ccgtggacaa gagcagcagc accgcctaca tgcagctgag cagcctgacc agcgaggaca     2220

gcgccgtgta ctactgcgcc agaggcaact gggacgacta ctggggccag ggcaccaccc     2280

tgaccgtgag cagcaccacg acgccagcgc cgcgaccacc aacaccggcg cccaccatcg     2340

cgtcgcagcc cctgtccctg cgcccagagg cgtgccggcc agcggcgggg ggcgcagtgc     2400

acacgagggg gctggacttc gcctgtgata tctacatctg ggcgcccttg gccgggactt     2460

gtggggtcct tctcctgtca ctggttatca ccctttactg caggagtaag aggagcaggc     2520

tcctgcacag tgactacatg aacatgactc cccgccgccc cgggcccacc cgcaagcatt     2580

accagcccta tgccccacca cgcgacttcg cagcctatcg ctccagagtg aagttcagca     2640

ggagcgcaga cgcccccgcg taccagcagg gccagaacca gctctataac gagctcaatc     2700

taggacgaag agaggagtac gatgttttgg acaagagacg tggccgggac cctgagatgg     2760

ggggaaagcc gcagagaagg aagaaccctc aggaaggcct gtacaatgaa ctgcagaaag     2820

ataagatggc ggaggcctac agtgagattg ggatgaaagg cgagcgccgg aggggcaagg     2880

ggcacgatgg cctttaccag ggtctcagta cagccaccaa ggacacctac gacgcccttc     2940

acatgcaggc cctgccccct cgcggcagcg gcgaaggccg cggcagcctg ctgacctgcg     3000

gcgatgtgga agaaaacccg ggccccatgg aatacgcctc tgacgcttca ctggaccccg     3060

aagccccgtg gcctcccgcg ccccgcgctc gcgcctgccg cgtactgcct tgggccctgg     3120

tcgcggggct gctgctgctg ctgctgctcg ctgccgcctg cgccgtcttc ctcgcctgcc     3180

cctgggccgt gtccggggct cgcgcctcgc ccggctccgc ggccagcccg agactccgcg     3240

agggtcccga gctttcgccc gacgatcccg ccggcctctt ggacctgcgg cagggcatgt     3300

ttgcgcagct ggtggcccaa aatgttctgc tgatcgatgg gcccctgagc tggtacagtg     3360

acccaggcct ggcaggcgtg tccctgacgg ggggcctgag ctacaaagag gacacgaagg     3420

agctggtggt ggccaaggct ggagtctact atgtcttctt tcaactagag ctgcggcgcg     3480

tggtggccgg cgagggctca ggctccgttt cacttgcgct gcacctgcag ccactgcgct     3540

ctgctgctgg ggccgccgcc ctggctttga ccgtggacct gccacccgcc tcctccgagg     3600

ctcggaactc ggccttcggt ttccagggcc gcttgctgca cctgagtgcc ggccagcgcc     3660

tgggcgtcca tcttcacact gaggccaggg cacgccatgc ctggcagctt acccagggcg     3720

ccacagtctt gggactcttc cgggtgaccc ccgaaatccc agccggactc ccttcaccga     3780

ggtcggaata agtttaaac                                                  3799


<210>  38
<211>  1260
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  38

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gln Ile Val Leu Thr Gln Ser Pro Ala Ile Met 
            20                  25                  30          


Ser Ala Ser Pro Gly Glu Lys Val Thr Ile Thr Cys Ser Ala Ser Ser 
        35                  40                  45              


Ser Ile Ser Tyr Met His Trp Phe Gln Gln Lys Pro Gly Thr Ser Pro 
    50                  55                  60                  


Lys Leu Trp Ile Tyr Thr Thr Ser Asn Leu Ala Ser Gly Val Pro Ala 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser 
                85                  90                  95      


Arg Met Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys His Gln Arg Ser 
            100                 105                 110         


Thr Tyr Pro Leu Thr Phe Gly Ser Gly Thr Lys Leu Glu Leu Lys Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val 
    130                 135                 140                 


Gln Leu Gln Gln Ser Gly Ala Glu Leu Ala Lys Pro Gly Ala Ser Val 
145                 150                 155                 160 


Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr Arg Met 
                165                 170                 175     


His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile Gly Tyr 
            180                 185                 190         


Ile Asn Pro Ser Thr Gly Tyr Thr Glu Tyr Asn Gln Lys Phe Lys Asp 
        195                 200                 205             


Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr Met Gln 
    210                 215                 220                 


Leu Ser Ser Leu Thr Phe Glu Asp Ser Ala Val Tyr Tyr Cys Ala Arg 
225                 230                 235                 240 


Gly Gly Gly Val Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val 
                245                 250                 255     


Ser Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr 
            260                 265                 270         


Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala 
        275                 280                 285             


Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile 
    290                 295                 300                 


Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser 
305                 310                 315                 320 


Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr 
                325                 330                 335     


Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu 
            340                 345                 350         


Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu 
        355                 360                 365             


Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln 
    370                 375                 380                 


Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu 
385                 390                 395                 400 


Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly 
                405                 410                 415     


Lys Pro Gln Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu 
            420                 425                 430         


Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly 
        435                 440                 445             


Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser 
    450                 455                 460                 


Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro 
465                 470                 475                 480 


Pro Arg Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly 
                485                 490                 495     


Asp Val Glu Glu Asn Pro Gly Pro Met Ala Leu Pro Val Thr Ala Leu 
            500                 505                 510         


Leu Leu Pro Leu Ala Leu Leu Leu His Ala Ala Arg Pro Asp Val Gln 
        515                 520                 525             


Ile Thr Gln Ser Pro Ser Tyr Leu Ala Ala Ser Pro Gly Glu Thr Ile 
    530                 535                 540                 


Thr Ile Asn Cys Arg Ala Ser Lys Ser Ile Ser Lys Asp Leu Ala Trp 
545                 550                 555                 560 


Tyr Gln Glu Lys Pro Gly Lys Thr Asn Lys Leu Leu Ile Tyr Ser Gly 
                565                 570                 575     


Ser Thr Leu Gln Ser Gly Ile Pro Ser Arg Phe Ser Gly Ser Gly Ser 
            580                 585                 590         


Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro Glu Asp Phe 
        595                 600                 605             


Ala Met Tyr Tyr Cys Gln Gln His Asn Lys Tyr Pro Tyr Thr Phe Gly 
    610                 615                 620                 


Gly Gly Thr Lys Leu Glu Ile Lys Gly Gly Gly Gly Ser Gly Gly Gly 
625                 630                 635                 640 


Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Gln Gln Pro Gly Ala 
                645                 650                 655     


Glu Leu Val Arg Pro Gly Ala Ser Val Lys Leu Ser Cys Lys Ala Ser 
            660                 665                 670         


Gly Tyr Thr Phe Thr Ser Tyr Trp Met Asn Trp Val Lys Gln Arg Pro 
        675                 680                 685             


Asp Gln Gly Leu Glu Trp Ile Gly Arg Ile Asp Pro Tyr Asp Ser Glu 
    690                 695                 700                 


Thr His Tyr Asn Gln Lys Phe Lys Asp Lys Ala Ile Leu Thr Val Asp 
705                 710                 715                 720 


Lys Ser Ser Ser Thr Ala Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu 
                725                 730                 735     


Asp Ser Ala Val Tyr Tyr Cys Ala Arg Gly Asn Trp Asp Asp Tyr Trp 
            740                 745                 750         


Gly Gln Gly Thr Thr Leu Thr Val Ser Ser Thr Thr Thr Pro Ala Pro 
        755                 760                 765             


Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu 
    770                 775                 780                 


Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg 
785                 790                 795                 800 


Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly 
                805                 810                 815     


Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Arg 
            820                 825                 830         


Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro 
        835                 840                 845             


Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro 
    850                 855                 860                 


Arg Asp Phe Ala Ala Tyr Arg Ser Arg Val Lys Phe Ser Arg Ser Ala 
865                 870                 875                 880 


Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu 
                885                 890                 895     


Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly 
            900                 905                 910         


Arg Asp Pro Glu Met Gly Gly Lys Pro Gln Arg Arg Lys Asn Pro Gln 
        915                 920                 925             


Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr 
    930                 935                 940                 


Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp 
945                 950                 955                 960 


Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala 
                965                 970                 975     


Leu His Met Gln Ala Leu Pro Pro Arg Gly Ser Gly Glu Gly Arg Gly 
            980                 985                 990         


Ser Leu Leu Thr Cys Gly Asp Val  Glu Glu Asn Pro Gly  Pro Met Glu 
        995                 1000                 1005             


Tyr Ala  Ser Asp Ala Ser Leu  Asp Pro Glu Ala Pro  Trp Pro Pro 
    1010                 1015                 1020             


Ala Pro  Arg Ala Arg Ala Cys  Arg Val Leu Pro Trp  Ala Leu Val 
    1025                 1030                 1035             


Ala Gly  Leu Leu Leu Leu Leu  Leu Leu Ala Ala Ala  Cys Ala Val 
    1040                 1045                 1050             


Phe Leu  Ala Cys Pro Trp Ala  Val Ser Gly Ala Arg  Ala Ser Pro 
    1055                 1060                 1065             


Gly Ser  Ala Ala Ser Pro Arg  Leu Arg Glu Gly Pro  Glu Leu Ser 
    1070                 1075                 1080             


Pro Asp  Asp Pro Ala Gly Leu  Leu Asp Leu Arg Gln  Gly Met Phe 
    1085                 1090                 1095             


Ala Gln  Leu Val Ala Gln Asn  Val Leu Leu Ile Asp  Gly Pro Leu 
    1100                 1105                 1110             


Ser Trp  Tyr Ser Asp Pro Gly  Leu Ala Gly Val Ser  Leu Thr Gly 
    1115                 1120                 1125             


Gly Leu  Ser Tyr Lys Glu Asp  Thr Lys Glu Leu Val  Val Ala Lys 
    1130                 1135                 1140             


Ala Gly  Val Tyr Tyr Val Phe  Phe Gln Leu Glu Leu  Arg Arg Val 
    1145                 1150                 1155             


Val Ala  Gly Glu Gly Ser Gly  Ser Val Ser Leu Ala  Leu His Leu 
    1160                 1165                 1170             


Gln Pro  Leu Arg Ser Ala Ala  Gly Ala Ala Ala Leu  Ala Leu Thr 
    1175                 1180                 1185             


Val Asp  Leu Pro Pro Ala Ser  Ser Glu Ala Arg Asn  Ser Ala Phe 
    1190                 1195                 1200             


Gly Phe  Gln Gly Arg Leu Leu  His Leu Ser Ala Gly  Gln Arg Leu 
    1205                 1210                 1215             


Gly Val  His Leu His Thr Glu  Ala Arg Ala Arg His  Ala Trp Gln 
    1220                 1225                 1230             


Leu Thr  Gln Gly Ala Thr Val  Leu Gly Leu Phe Arg  Val Thr Pro 
    1235                 1240                 1245             


Glu Ile  Pro Ala Gly Leu Pro  Ser Pro Arg Ser Glu  
    1250                 1255                 1260 


<210>  39
<211>  3856
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  39
gcgatcgcat ggccttacca gtgaccgcct tgctcctgcc gctggccttg ctgctccacg       60

ccgccaggcc gcagatcgtg ctgacccaga gccccgccat catgagcgcc agccccggcg      120

agaaggtgac catcacctgc agcgccagca gcagcatcag ctacatgcac tggttccagc      180

agaagcccgg caccagcccc aagctgtgga tctacaccac cagcaacctg gccagcggcg      240

tgcccgccag attcagcggc agcggcagcg gcaccagcta cagcctgacc atcagcagaa      300

tggaggccga ggacgccgcc acctactact gccaccagag aagcacctac cccctgacct      360

tcggcagcgg caccaagctg gagctgaagg gagggggggg atccggggga ggaggctccg      420

gcggaggcgg aagccaggtg cagctgcagc agagcggcgc cgagctggcc aagcccggcg      480

ccagcgtgaa gatgagctgc aaggccagcg gctacacctt caccagctac agaatgcact      540

gggtgaagca gagacccggc cagggcctgg agtggatcgg ctacatcaac cccagcaccg      600

gctacaccga gtacaaccag aagttcaagg acaaggccac cctgaccgcc gacaagagca      660

gcagcaccgc ctacatgcag ctgagcagcc tgaccttcga ggacagcgcc gtgtactact      720

gcgccagagg cggcggcgtg ttcgactact ggggccaggg caccaccctg accgtgagca      780

gcaccacgac gccagcgccg cgaccaccaa caccggcgcc caccatcgcg tcgcagcccc      840

tgtccctgcg cccagaggcg tgccggccag cggcgggggg cgcagtgcac acgagggggc      900

tggacttcgc ctgtgatatc tacatctggg cgcccttggc cgggacttgt ggggtccttc      960

tcctgtcact ggttatcacc ctttactgca aacggggcag aaagaaactc ctgtatatat     1020

tcaaacaacc atttatgaga ccagtacaaa ctactcaaga ggaagatggc tgtagctgcc     1080

gatttccaga agaagaagaa ggaggatgtg aactgagagt gaagttcagc aggagcgcag     1140

acgcccccgc gtaccagcag ggccagaacc agctctataa cgagctcaat ctaggacgaa     1200

gagaggagta cgatgttttg gacaagagac gtggccggga ccctgagatg gggggaaagc     1260

cgcagagaag gaagaaccct caggaaggcc tgtacaatga actgcagaaa gataagatgg     1320

cggaggccta cagtgagatt gggatgaaag gcgagcgccg gaggggcaag gggcacgatg     1380

gcctttacca gggtctcagt acagccacca aggacaccta cgacgccctt cacatgcagg     1440

ccctgccccc tcgcggaagc ggagctacta acttcagcct gctgaagcag gctggagacg     1500

tggaggagaa ccctggacct atggccttac cagtgaccgc cttgctcctg ccgctggcct     1560

tgctgctcca cgccgccagg ccggacgtgc agatcaccca gagccccagc tacctggccg     1620

ccagccccgg cgagaccatc accatcaact gcagagccag caagagcatc agcaaggacc     1680

tggcctggta ccaggagaag cccggcaaga ccaacaagct gctgatctac agcggcagca     1740

ccctgcagag cggcatcccc agcagattca gcggcagcgg cagcggcacc gacttcaccc     1800

tgaccatcag cagcctggag cccgaggact tcgccatgta ctactgccag cagcacaaca     1860

agtaccccta caccttcggc ggcggcacca agctggagat caagggaggg gggggatccg     1920

ggggaggagg ctccggcgga ggcggaagcc aggtgcagct gcagcagccc ggcgccgagc     1980

tggtgagacc cggcgccagc gtgaagctga gctgcaaggc cagcggctac accttcacca     2040

gctactggat gaactgggtg aagcagagac ccgaccaggg cctggagtgg atcggcagaa     2100

tcgaccccta cgacagcgag acccactaca accagaagtt caaggacaag gccatcctga     2160

ccgtggacaa gagcagcagc accgcctaca tgcagctgag cagcctgacc agcgaggaca     2220

gcgccgtgta ctactgcgcc agaggcaact gggacgacta ctggggccag ggcaccaccc     2280

tgaccgtgag cagcaccacg acgccagcgc cgcgaccacc aacaccggcg cccaccatcg     2340

cgtcgcagcc cctgtccctg cgcccagagg cgtgccggcc agcggcgggg ggcgcagtgc     2400

acacgagggg gctggacttc gcctgtgata tctacatctg ggcgcccttg gccgggactt     2460

gtggggtcct tctcctgtca ctggttatca ccctttactg caggagtaag aggagcaggc     2520

tcctgcacag tgactacatg aacatgactc cccgccgccc cgggcccacc cgcaagcatt     2580

accagcccta tgccccacca cgcgacttcg cagcctatcg ctccagagtg aagttcagca     2640

ggagcgcaga cgcccccgcg taccagcagg gccagaacca gctctataac gagctcaatc     2700

taggacgaag agaggagtac gatgttttgg acaagagacg tggccgggac cctgagatgg     2760

ggggaaagcc gcagagaagg aagaaccctc aggaaggcct gtacaatgaa ctgcagaaag     2820

ataagatggc ggaggcctac agtgagattg ggatgaaagg cgagcgccgg aggggcaagg     2880

ggcacgatgg cctttaccag ggtctcagta cagccaccaa ggacacctac gacgcccttc     2940

acatgcaggc cctgccccct cgcggcagcg gcgaaggccg cggcagcctg ctgacctgcg     3000

gcgatgtgga agaaaacccg ggccccatgt acagaatgca gctgctgagc tgcatcgccc     3060

tgagcctggc cctggtgacc aacagcggca tccacgtgtt catcctgggc tgcttcagcg     3120

ccggcctgcc caagaccgag gccaactggg tgaacgtgat cagcgacctg aagaagatcg     3180

aggacctgat ccagagcatg cacatcgacg ccaccctgta caccgagagc gacgtgcacc     3240

ccagctgcaa ggtgaccgcc atgaagtgct tcctgctgga gctgcaggtg atcagcctgg     3300

agagcggcga cgccagcatc cacgacaccg tggagaacct gatcatcctg gccaacaaca     3360

gcctgagcag caacggcaac gtgaccgaga gcggctgcaa ggagtgcgag gagctggagg     3420

agaagaacat caaggagttc ctgcagagct tcgtgcacat cgtgcagatg ttcatcaaca     3480

ccagctccgg cggcggctcc ggcggcggcg gctccggcgg cggcggctcc ggcggcggcg     3540

gctccggcgg cggctccctg caggccccca gaagagccag aggctgcaga accctgggcc     3600

tgcccgccct gctgctgctg ctgctgctga gaccccccgc caccagaggc atcacctgcc     3660

ccccccccat gagcgtggag cacgccgaca tctgggtgaa gagctacagc ctgtacagca     3720

gagagagata catctgcaac agcggcttca agagaaaggc cggcaccagc agcctgaccg     3780

agtgcgtgct gaacaaggcc accaacgtgg cccactggac cacccccagc ctgaagtgca     3840

tcagataagt ttaaac                                                     3856


<210>  40
<211>  1279
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  40

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gln Ile Val Leu Thr Gln Ser Pro Ala Ile Met 
            20                  25                  30          


Ser Ala Ser Pro Gly Glu Lys Val Thr Ile Thr Cys Ser Ala Ser Ser 
        35                  40                  45              


Ser Ile Ser Tyr Met His Trp Phe Gln Gln Lys Pro Gly Thr Ser Pro 
    50                  55                  60                  


Lys Leu Trp Ile Tyr Thr Thr Ser Asn Leu Ala Ser Gly Val Pro Ala 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser 
                85                  90                  95      


Arg Met Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys His Gln Arg Ser 
            100                 105                 110         


Thr Tyr Pro Leu Thr Phe Gly Ser Gly Thr Lys Leu Glu Leu Lys Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val 
    130                 135                 140                 


Gln Leu Gln Gln Ser Gly Ala Glu Leu Ala Lys Pro Gly Ala Ser Val 
145                 150                 155                 160 


Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr Arg Met 
                165                 170                 175     


His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile Gly Tyr 
            180                 185                 190         


Ile Asn Pro Ser Thr Gly Tyr Thr Glu Tyr Asn Gln Lys Phe Lys Asp 
        195                 200                 205             


Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr Met Gln 
    210                 215                 220                 


Leu Ser Ser Leu Thr Phe Glu Asp Ser Ala Val Tyr Tyr Cys Ala Arg 
225                 230                 235                 240 


Gly Gly Gly Val Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val 
                245                 250                 255     


Ser Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr 
            260                 265                 270         


Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala 
        275                 280                 285             


Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile 
    290                 295                 300                 


Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser 
305                 310                 315                 320 


Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr 
                325                 330                 335     


Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu 
            340                 345                 350         


Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu 
        355                 360                 365             


Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln 
    370                 375                 380                 


Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu 
385                 390                 395                 400 


Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly 
                405                 410                 415     


Lys Pro Gln Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu 
            420                 425                 430         


Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly 
        435                 440                 445             


Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser 
    450                 455                 460                 


Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro 
465                 470                 475                 480 


Pro Arg Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly 
                485                 490                 495     


Asp Val Glu Glu Asn Pro Gly Pro Met Ala Leu Pro Val Thr Ala Leu 
            500                 505                 510         


Leu Leu Pro Leu Ala Leu Leu Leu His Ala Ala Arg Pro Asp Val Gln 
        515                 520                 525             


Ile Thr Gln Ser Pro Ser Tyr Leu Ala Ala Ser Pro Gly Glu Thr Ile 
    530                 535                 540                 


Thr Ile Asn Cys Arg Ala Ser Lys Ser Ile Ser Lys Asp Leu Ala Trp 
545                 550                 555                 560 


Tyr Gln Glu Lys Pro Gly Lys Thr Asn Lys Leu Leu Ile Tyr Ser Gly 
                565                 570                 575     


Ser Thr Leu Gln Ser Gly Ile Pro Ser Arg Phe Ser Gly Ser Gly Ser 
            580                 585                 590         


Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro Glu Asp Phe 
        595                 600                 605             


Ala Met Tyr Tyr Cys Gln Gln His Asn Lys Tyr Pro Tyr Thr Phe Gly 
    610                 615                 620                 


Gly Gly Thr Lys Leu Glu Ile Lys Gly Gly Gly Gly Ser Gly Gly Gly 
625                 630                 635                 640 


Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Gln Gln Pro Gly Ala 
                645                 650                 655     


Glu Leu Val Arg Pro Gly Ala Ser Val Lys Leu Ser Cys Lys Ala Ser 
            660                 665                 670         


Gly Tyr Thr Phe Thr Ser Tyr Trp Met Asn Trp Val Lys Gln Arg Pro 
        675                 680                 685             


Asp Gln Gly Leu Glu Trp Ile Gly Arg Ile Asp Pro Tyr Asp Ser Glu 
    690                 695                 700                 


Thr His Tyr Asn Gln Lys Phe Lys Asp Lys Ala Ile Leu Thr Val Asp 
705                 710                 715                 720 


Lys Ser Ser Ser Thr Ala Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu 
                725                 730                 735     


Asp Ser Ala Val Tyr Tyr Cys Ala Arg Gly Asn Trp Asp Asp Tyr Trp 
            740                 745                 750         


Gly Gln Gly Thr Thr Leu Thr Val Ser Ser Thr Thr Thr Pro Ala Pro 
        755                 760                 765             


Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu 
    770                 775                 780                 


Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg 
785                 790                 795                 800 


Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly 
                805                 810                 815     


Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Arg 
            820                 825                 830         


Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro 
        835                 840                 845             


Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro 
    850                 855                 860                 


Arg Asp Phe Ala Ala Tyr Arg Ser Arg Val Lys Phe Ser Arg Ser Ala 
865                 870                 875                 880 


Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu 
                885                 890                 895     


Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly 
            900                 905                 910         


Arg Asp Pro Glu Met Gly Gly Lys Pro Gln Arg Arg Lys Asn Pro Gln 
        915                 920                 925             


Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr 
    930                 935                 940                 


Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp 
945                 950                 955                 960 


Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala 
                965                 970                 975     


Leu His Met Gln Ala Leu Pro Pro Arg Gly Ser Gly Glu Gly Arg Gly 
            980                 985                 990         


Ser Leu Leu Thr Cys Gly Asp Val  Glu Glu Asn Pro Gly  Pro Met Tyr 
        995                 1000                 1005             


Arg Met  Gln Leu Leu Ser Cys  Ile Ala Leu Ser Leu  Ala Leu Val 
    1010                 1015                 1020             


Thr Asn  Ser Gly Ile His Val  Phe Ile Leu Gly Cys  Phe Ser Ala 
    1025                 1030                 1035             


Gly Leu  Pro Lys Thr Glu Ala  Asn Trp Val Asn Val  Ile Ser Asp 
    1040                 1045                 1050             


Leu Lys  Lys Ile Glu Asp Leu  Ile Gln Ser Met His  Ile Asp Ala 
    1055                 1060                 1065             


Thr Leu  Tyr Thr Glu Ser Asp  Val His Pro Ser Cys  Lys Val Thr 
    1070                 1075                 1080             


Ala Met  Lys Cys Phe Leu Leu  Glu Leu Gln Val Ile  Ser Leu Glu 
    1085                 1090                 1095             


Ser Gly  Asp Ala Ser Ile His  Asp Thr Val Glu Asn  Leu Ile Ile 
    1100                 1105                 1110             


Leu Ala  Asn Asn Ser Leu Ser  Ser Asn Gly Asn Val  Thr Glu Ser 
    1115                 1120                 1125             


Gly Cys  Lys Glu Cys Glu Glu  Leu Glu Glu Lys Asn  Ile Lys Glu 
    1130                 1135                 1140             


Phe Leu  Gln Ser Phe Val His  Ile Val Gln Met Phe  Ile Asn Thr 
    1145                 1150                 1155             


Ser Ser  Gly Gly Gly Ser Gly  Gly Gly Gly Ser Gly  Gly Gly Gly 
    1160                 1165                 1170             


Ser Gly  Gly Gly Gly Ser Gly  Gly Gly Ser Leu Gln  Ala Pro Arg 
    1175                 1180                 1185             


Arg Ala  Arg Gly Cys Arg Thr  Leu Gly Leu Pro Ala  Leu Leu Leu 
    1190                 1195                 1200             


Leu Leu  Leu Leu Arg Pro Pro  Ala Thr Arg Gly Ile  Thr Cys Pro 
    1205                 1210                 1215             


Pro Pro  Met Ser Val Glu His  Ala Asp Ile Trp Val  Lys Ser Tyr 
    1220                 1225                 1230             


Ser Leu  Tyr Ser Arg Glu Arg  Tyr Ile Cys Asn Ser  Gly Phe Lys 
    1235                 1240                 1245             


Arg Lys  Ala Gly Thr Ser Ser  Leu Thr Glu Cys Val  Leu Asn Lys 
    1250                 1255                 1260             


Ala Thr  Asn Val Ala His Trp  Thr Thr Pro Ser Leu  Lys Cys Ile 
    1265                 1270                 1275             


Arg 
    


<210>  41
<211>  2314
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  41
gcgatcgcat ggccttacca gtgaccgcct tgctcctgcc gctggccttg ctgctccacg       60

ccgccaggcc ggacatcgtg ctgacccaga gccccgccag cctggccgtg agcctgggcc      120

agagggccac catcagctgc agggccagca agagcgtgag caccagcggc tacagctacc      180

tgcactggta ccagcagaag cccggccagc cccccaagct gctgatctac ctggccagca      240

acctggagag cggcgtgccc gccaggttca gcggcagcgg cagcggcacc gacttcaccc      300

tgaacatcca ccccgtggag gaggaggacg ccgccaccta ctactgccag cacagcaggg      360

agctgccctt caccttcggc agcggcacca agctggagat caagggaggg gggggatccg      420

ggggaggagg ctccggcgga ggcggaagcc aggtgcagct ggtggagagc ggcggcggcc      480

tggtgcagcc cggcggcagc ctgaagctga gctgcgccgc cagcggcttc gacttcagca      540

ggtactggat gagctgggtg aggcaggccc ccggcaaggg cctggagtgg atcggcgaga      600

tcaaccccac cagcagcacc atcaacttca cccccagcct gaaggacaag gtgttcatca      660

gcagggacaa cgccaagaac accctgtacc tgcagatgag caaggtgagg agcgaggaca      720

ccgccctgta ctactgcgcc aggggcaact actacaggta cggcgacgcc atggactact      780

ggggccaggg caccagcgtg accgtgagca ccacgacgcc agcgccgcga ccaccaacac      840

cggcgcccac catcgcgtcg cagcccctgt ccctgcgccc agaggcgtgc cggccagcgg      900

cggggggcgc agtgcacacg agggggctgg acttcgcctg tgatatctac atctgggcgc      960

ccttggccgg gacttgtggg gtccttctcc tgtcactggt tatcaccctt tactgcagga     1020

gtaagaggag caggctcctg cacagtgact acatgaacat gactccccgc cgccccgggc     1080

ccacccgcaa gcattaccag ccctatgccc caccacgcga cttcgcagcc tatcgctcca     1140

gagtgaagtt cagcaggagc gcagacgccc ccgcgtacca gcagggccag aaccagctct     1200

ataacgagct caatctagga cgaagagagg agtacgatgt tttggacaag agacgtggcc     1260

gggaccctga gatgggggga aagccgcaga gaaggaagaa ccctcaggaa ggcctgtaca     1320

atgaactgca gaaagataag atggcggagg cctacagtga gattgggatg aaaggcgagc     1380

gccggagggg caaggggcac gatggccttt accagggtct cagtacagcc accaaggaca     1440

cctacgacgc ccttcacatg caggccctgc cccctcgcgg cagcggcgaa ggccgcggca     1500

gcctgctgac ctgcggcgat gtggaagaaa acccgggccc catggaatac gcctctgacg     1560

cttcactgga ccccgaagcc ccgtggcctc ccgcgccccg cgctcgcgcc tgccgcgtac     1620

tgccttgggc cctggtcgcg gggctgctgc tgctgctgct gctcgctgcc gcctgcgccg     1680

tcttcctcgc ctgcccctgg gccgtgtccg gggctcgcgc ctcgcccggc tccgcggcca     1740

gcccgagact ccgcgagggt cccgagcttt cgcccgacga tcccgccggc ctcttggacc     1800

tgcggcaggg catgtttgcg cagctggtgg cccaaaatgt tctgctgatc gatgggcccc     1860

tgagctggta cagtgaccca ggcctggcag gcgtgtccct gacggggggc ctgagctaca     1920

aagaggacac gaaggagctg gtggtggcca aggctggagt ctactatgtc ttctttcaac     1980

tagagctgcg gcgcgtggtg gccggcgagg gctcaggctc cgtttcactt gcgctgcacc     2040

tgcagccact gcgctctgct gctggggccg ccgccctggc tttgaccgtg gacctgccac     2100

ccgcctcctc cgaggctcgg aactcggcct tcggtttcca gggccgcttg ctgcacctga     2160

gtgccggcca gcgcctgggc gtccatcttc acactgaggc cagggcacgc catgcctggc     2220

agcttaccca gggcgccaca gtcttgggac tcttccgggt gacccccgaa atcccagccg     2280

gactcccttc accgaggtcg gaataagttt aaac                                 2314


<210>  42
<211>  765
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  42

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu 
            20                  25                  30          


Ala Val Ser Leu Gly Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Lys 
        35                  40                  45              


Ser Val Ser Thr Ser Gly Tyr Ser Tyr Leu His Trp Tyr Gln Gln Lys 
    50                  55                  60                  


Pro Gly Gln Pro Pro Lys Leu Leu Ile Tyr Leu Ala Ser Asn Leu Glu 
65                  70                  75                  80  


Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 
                85                  90                  95      


Thr Leu Asn Ile His Pro Val Glu Glu Glu Asp Ala Ala Thr Tyr Tyr 
            100                 105                 110         


Cys Gln His Ser Arg Glu Leu Pro Phe Thr Phe Gly Ser Gly Thr Lys 
        115                 120                 125             


Leu Glu Ile Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln 
145                 150                 155                 160 


Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Asp Phe 
                165                 170                 175     


Ser Arg Tyr Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
            180                 185                 190         


Glu Trp Ile Gly Glu Ile Asn Pro Thr Ser Ser Thr Ile Asn Phe Thr 
        195                 200                 205             


Pro Ser Leu Lys Asp Lys Val Phe Ile Ser Arg Asp Asn Ala Lys Asn 
    210                 215                 220                 


Thr Leu Tyr Leu Gln Met Ser Lys Val Arg Ser Glu Asp Thr Ala Leu 
225                 230                 235                 240 


Tyr Tyr Cys Ala Arg Gly Asn Tyr Tyr Arg Tyr Gly Asp Ala Met Asp 
                245                 250                 255     


Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Thr Thr Thr Pro Ala 
            260                 265                 270         


Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser 
        275                 280                 285             


Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr 
    290                 295                 300                 


Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala 
305                 310                 315                 320 


Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys 
                325                 330                 335     


Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr 
            340                 345                 350         


Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro 
        355                 360                 365             


Pro Arg Asp Phe Ala Ala Tyr Arg Ser Arg Val Lys Phe Ser Arg Ser 
    370                 375                 380                 


Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu 
385                 390                 395                 400 


Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg 
                405                 410                 415     


Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Gln Arg Arg Lys Asn Pro 
            420                 425                 430         


Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala 
        435                 440                 445             


Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His 
    450                 455                 460                 


Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp 
465                 470                 475                 480 


Ala Leu His Met Gln Ala Leu Pro Pro Arg Gly Ser Gly Glu Gly Arg 
                485                 490                 495     


Gly Ser Leu Leu Thr Cys Gly Asp Val Glu Glu Asn Pro Gly Pro Met 
            500                 505                 510         


Glu Tyr Ala Ser Asp Ala Ser Leu Asp Pro Glu Ala Pro Trp Pro Pro 
        515                 520                 525             


Ala Pro Arg Ala Arg Ala Cys Arg Val Leu Pro Trp Ala Leu Val Ala 
    530                 535                 540                 


Gly Leu Leu Leu Leu Leu Leu Leu Ala Ala Ala Cys Ala Val Phe Leu 
545                 550                 555                 560 


Ala Cys Pro Trp Ala Val Ser Gly Ala Arg Ala Ser Pro Gly Ser Ala 
                565                 570                 575     


Ala Ser Pro Arg Leu Arg Glu Gly Pro Glu Leu Ser Pro Asp Asp Pro 
            580                 585                 590         


Ala Gly Leu Leu Asp Leu Arg Gln Gly Met Phe Ala Gln Leu Val Ala 
        595                 600                 605             


Gln Asn Val Leu Leu Ile Asp Gly Pro Leu Ser Trp Tyr Ser Asp Pro 
    610                 615                 620                 


Gly Leu Ala Gly Val Ser Leu Thr Gly Gly Leu Ser Tyr Lys Glu Asp 
625                 630                 635                 640 


Thr Lys Glu Leu Val Val Ala Lys Ala Gly Val Tyr Tyr Val Phe Phe 
                645                 650                 655     


Gln Leu Glu Leu Arg Arg Val Val Ala Gly Glu Gly Ser Gly Ser Val 
            660                 665                 670         


Ser Leu Ala Leu His Leu Gln Pro Leu Arg Ser Ala Ala Gly Ala Ala 
        675                 680                 685             


Ala Leu Ala Leu Thr Val Asp Leu Pro Pro Ala Ser Ser Glu Ala Arg 
    690                 695                 700                 


Asn Ser Ala Phe Gly Phe Gln Gly Arg Leu Leu His Leu Ser Ala Gly 
705                 710                 715                 720 


Gln Arg Leu Gly Val His Leu His Thr Glu Ala Arg Ala Arg His Ala 
                725                 730                 735     


Trp Gln Leu Thr Gln Gly Ala Thr Val Leu Gly Leu Phe Arg Val Thr 
            740                 745                 750         


Pro Glu Ile Pro Ala Gly Leu Pro Ser Pro Arg Ser Glu 
        755                 760                 765 


<210>  43
<211>  2371
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  43
gcgatcgcat ggccttacca gtgaccgcct tgctcctgcc gctggccttg ctgctccacg       60

ccgccaggcc ggacatcgtg ctgacccaga gccccgccag cctggccgtg agcctgggcc      120

agagggccac catcagctgc agggccagca agagcgtgag caccagcggc tacagctacc      180

tgcactggta ccagcagaag cccggccagc cccccaagct gctgatctac ctggccagca      240

acctggagag cggcgtgccc gccaggttca gcggcagcgg cagcggcacc gacttcaccc      300

tgaacatcca ccccgtggag gaggaggacg ccgccaccta ctactgccag cacagcaggg      360

agctgccctt caccttcggc agcggcacca agctggagat caagggaggg gggggatccg      420

ggggaggagg ctccggcgga ggcggaagcc aggtgcagct ggtggagagc ggcggcggcc      480

tggtgcagcc cggcggcagc ctgaagctga gctgcgccgc cagcggcttc gacttcagca      540

ggtactggat gagctgggtg aggcaggccc ccggcaaggg cctggagtgg atcggcgaga      600

tcaaccccac cagcagcacc atcaacttca cccccagcct gaaggacaag gtgttcatca      660

gcagggacaa cgccaagaac accctgtacc tgcagatgag caaggtgagg agcgaggaca      720

ccgccctgta ctactgcgcc aggggcaact actacaggta cggcgacgcc atggactact      780

ggggccaggg caccagcgtg accgtgagca ccacgacgcc agcgccgcga ccaccaacac      840

cggcgcccac catcgcgtcg cagcccctgt ccctgcgccc agaggcgtgc cggccagcgg      900

cggggggcgc agtgcacacg agggggctgg acttcgcctg tgatatctac atctgggcgc      960

ccttggccgg gacttgtggg gtccttctcc tgtcactggt tatcaccctt tactgcagga     1020

gtaagaggag caggctcctg cacagtgact acatgaacat gactccccgc cgccccgggc     1080

ccacccgcaa gcattaccag ccctatgccc caccacgcga cttcgcagcc tatcgctcca     1140

gagtgaagtt cagcaggagc gcagacgccc ccgcgtacca gcagggccag aaccagctct     1200

ataacgagct caatctagga cgaagagagg agtacgatgt tttggacaag agacgtggcc     1260

gggaccctga gatgggggga aagccgcaga gaaggaagaa ccctcaggaa ggcctgtaca     1320

atgaactgca gaaagataag atggcggagg cctacagtga gattgggatg aaaggcgagc     1380

gccggagggg caaggggcac gatggccttt accagggtct cagtacagcc accaaggaca     1440

cctacgacgc ccttcacatg caggccctgc cccctcgcgg cagcggcgaa ggccgcggca     1500

gcctgctgac ctgcggcgat gtggaagaaa acccgggccc catgtacaga atgcagctgc     1560

tgagctgcat cgccctgagc ctggccctgg tgaccaacag cggcatccac gtgttcatcc     1620

tgggctgctt cagcgccggc ctgcccaaga ccgaggccaa ctgggtgaac gtgatcagcg     1680

acctgaagaa gatcgaggac ctgatccaga gcatgcacat cgacgccacc ctgtacaccg     1740

agagcgacgt gcaccccagc tgcaaggtga ccgccatgaa gtgcttcctg ctggagctgc     1800

aggtgatcag cctggagagc ggcgacgcca gcatccacga caccgtggag aacctgatca     1860

tcctggccaa caacagcctg agcagcaacg gcaacgtgac cgagagcggc tgcaaggagt     1920

gcgaggagct ggaggagaag aacatcaagg agttcctgca gagcttcgtg cacatcgtgc     1980

agatgttcat caacaccagc tccggcggcg gctccggcgg cggcggctcc ggcggcggcg     2040

gctccggcgg cggcggctcc ggcggcggct ccctgcaggc ccccagaaga gccagaggct     2100

gcagaaccct gggcctgccc gccctgctgc tgctgctgct gctgagaccc cccgccacca     2160

gaggcatcac ctgccccccc cccatgagcg tggagcacgc cgacatctgg gtgaagagct     2220

acagcctgta cagcagagag agatacatct gcaacagcgg cttcaagaga aaggccggca     2280

ccagcagcct gaccgagtgc gtgctgaaca aggccaccaa cgtggcccac tggaccaccc     2340

ccagcctgaa gtgcatcaga taagtttaaa c                                    2371


<210>  44
<211>  784
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  44

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu 
            20                  25                  30          


Ala Val Ser Leu Gly Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Lys 
        35                  40                  45              


Ser Val Ser Thr Ser Gly Tyr Ser Tyr Leu His Trp Tyr Gln Gln Lys 
    50                  55                  60                  


Pro Gly Gln Pro Pro Lys Leu Leu Ile Tyr Leu Ala Ser Asn Leu Glu 
65                  70                  75                  80  


Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 
                85                  90                  95      


Thr Leu Asn Ile His Pro Val Glu Glu Glu Asp Ala Ala Thr Tyr Tyr 
            100                 105                 110         


Cys Gln His Ser Arg Glu Leu Pro Phe Thr Phe Gly Ser Gly Thr Lys 
        115                 120                 125             


Leu Glu Ile Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln 
145                 150                 155                 160 


Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Asp Phe 
                165                 170                 175     


Ser Arg Tyr Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
            180                 185                 190         


Glu Trp Ile Gly Glu Ile Asn Pro Thr Ser Ser Thr Ile Asn Phe Thr 
        195                 200                 205             


Pro Ser Leu Lys Asp Lys Val Phe Ile Ser Arg Asp Asn Ala Lys Asn 
    210                 215                 220                 


Thr Leu Tyr Leu Gln Met Ser Lys Val Arg Ser Glu Asp Thr Ala Leu 
225                 230                 235                 240 


Tyr Tyr Cys Ala Arg Gly Asn Tyr Tyr Arg Tyr Gly Asp Ala Met Asp 
                245                 250                 255     


Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Thr Thr Thr Pro Ala 
            260                 265                 270         


Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser 
        275                 280                 285             


Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr 
    290                 295                 300                 


Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala 
305                 310                 315                 320 


Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys 
                325                 330                 335     


Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr 
            340                 345                 350         


Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro 
        355                 360                 365             


Pro Arg Asp Phe Ala Ala Tyr Arg Ser Arg Val Lys Phe Ser Arg Ser 
    370                 375                 380                 


Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu 
385                 390                 395                 400 


Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg 
                405                 410                 415     


Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Gln Arg Arg Lys Asn Pro 
            420                 425                 430         


Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala 
        435                 440                 445             


Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His 
    450                 455                 460                 


Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp 
465                 470                 475                 480 


Ala Leu His Met Gln Ala Leu Pro Pro Arg Gly Ser Gly Glu Gly Arg 
                485                 490                 495     


Gly Ser Leu Leu Thr Cys Gly Asp Val Glu Glu Asn Pro Gly Pro Met 
            500                 505                 510         


Tyr Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu Val 
        515                 520                 525             


Thr Asn Ser Gly Ile His Val Phe Ile Leu Gly Cys Phe Ser Ala Gly 
    530                 535                 540                 


Leu Pro Lys Thr Glu Ala Asn Trp Val Asn Val Ile Ser Asp Leu Lys 
545                 550                 555                 560 


Lys Ile Glu Asp Leu Ile Gln Ser Met His Ile Asp Ala Thr Leu Tyr 
                565                 570                 575     


Thr Glu Ser Asp Val His Pro Ser Cys Lys Val Thr Ala Met Lys Cys 
            580                 585                 590         


Phe Leu Leu Glu Leu Gln Val Ile Ser Leu Glu Ser Gly Asp Ala Ser 
        595                 600                 605             


Ile His Asp Thr Val Glu Asn Leu Ile Ile Leu Ala Asn Asn Ser Leu 
    610                 615                 620                 


Ser Ser Asn Gly Asn Val Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu 
625                 630                 635                 640 


Leu Glu Glu Lys Asn Ile Lys Glu Phe Leu Gln Ser Phe Val His Ile 
                645                 650                 655     


Val Gln Met Phe Ile Asn Thr Ser Ser Gly Gly Gly Ser Gly Gly Gly 
            660                 665                 670         


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser 
        675                 680                 685             


Leu Gln Ala Pro Arg Arg Ala Arg Gly Cys Arg Thr Leu Gly Leu Pro 
    690                 695                 700                 


Ala Leu Leu Leu Leu Leu Leu Leu Arg Pro Pro Ala Thr Arg Gly Ile 
705                 710                 715                 720 


Thr Cys Pro Pro Pro Met Ser Val Glu His Ala Asp Ile Trp Val Lys 
                725                 730                 735     


Ser Tyr Ser Leu Tyr Ser Arg Glu Arg Tyr Ile Cys Asn Ser Gly Phe 
            740                 745                 750         


Lys Arg Lys Ala Gly Thr Ser Ser Leu Thr Glu Cys Val Leu Asn Lys 
        755                 760                 765             


Ala Thr Asn Val Ala His Trp Thr Thr Pro Ser Leu Lys Cys Ile Arg 
    770                 775                 780                 


<210>  45
<211>  2369
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  45
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccggatgtgg tgatgaccca gagccatcgc tttatgagca ccagcgtggg cgaccgagtg      120

agcattacct gccgcgcgag ccaggatgtg aacaccgcgg tgagctggta tcagcagaaa      180

ccgggccaga gcccgaaact gctgattttt agcgcgagct atcgctatac cggcgtgccg      240

gatcgcttta ccggcagcgg cagcggcgcg gattttaccc tgaccattag cagcgtgcag      300

gcggaagatc tggcggtgta ttattgccag cagcattata gcaccccgtg gacctttggc      360

ggcggcacca aactggacat taaaggaggg gggggatccg ggggaggagg ctccggcgga      420

ggcggaagcc agattcagct ggtgcagagc ggcccggatc tgaaaaaacc gggcgaaacc      480

gtgaaactga gctgcaaagc gagcggctat acctttacca actttggcat gaactgggtg      540

aaacaggcgc cgggcaaagg ctttaaatgg atggcgtgga ttaacaccac ccgctatacc      600

ggcgaaagct attttgcgga tgattttaaa ggccgctttg cgtttagcgt ggaaaccagc      660

gcgaccaccg cgtatctgca gattaacaac ctgaaaaccg aagataccgc gacctatttt      720

tgcgcgcgcg gcgaaattta ttatggctat gatggcggct ttgcgtattg gggccagggc      780

accctggtga ccgtgagcgc gaccacgacg ccagcgccgc gaccaccaac accggcgccc      840

accatcgcgt cgcagcccct gtccctgcgc ccagaggcgt gccggccagc ggcggggggc      900

gcagtgcaca cgagggggct ggacttcgcc tgtgatatct acatctgggc gcccttggcc      960

gggacttgtg gggtccttct cctgtcactg gttatcaccc tttactgcaa acggggcaga     1020

aagaaactcc tgtatatatt caaacaacca tttatgagac cagtacaaac tactcaagag     1080

gaagatggct gtagctgccg atttccagaa gaagaagaag gaggatgtga actgagagtg     1140

aagttcagca ggagcgcaga cgcccccgcg taccagcagg gccagaacca gctctataac     1200

gagctcaatc taggacgaag agaggagtac gatgttttgg acaagagacg tggccgggac     1260

cctgagatgg ggggaaagcc gcagagaagg aagaaccctc aggaaggcct gtacaatgaa     1320

ctgcagaaag ataagatggc ggaggcctac agtgagattg ggatgaaagg cgagcgccgg     1380

aggggcaagg ggcacgatgg cctttaccag ggtctcagta cagccaccaa ggacacctac     1440

gacgcccttc acatgcaggc cctgccccct cgcggaagcg gagccaccaa cttcagcctg     1500

ctgaagcagg ccggcgacgt ggaggagaac cccggcccca tgtacagaat gcagctgctg     1560

agctgcatcg ccctgagcct ggccctggtg accaacagcg gcatccacgt gttcatcctg     1620

ggctgcttca gcgccggcct gcccaagacc gaggccaact gggtgaacgt gatcagcgac     1680

ctgaagaaga tcgaggacct gatccagagc atgcacatcg acgccaccct gtacaccgag     1740

agcgacgtgc accccagctg caaggtgacc gccatgaagt gcttcctgct ggagctgcag     1800

gtgatcagcc tggagagcgg cgacgccagc atccacgaca ccgtggagaa cctgatcatc     1860

ctggccaaca acagcctgag cagcaacggc aacgtgaccg agagcggctg caaggagtgc     1920

gaggagctgg aggagaagaa catcaaggag ttcctgcaga gcttcgtgca catcgtgcag     1980

atgttcatca acaccagctc cggcggcggc tccggcggcg gcggctccgg cggcggcggc     2040

tccggcggcg gcggctccgg cggcggctcc ctgcaggccc ccagaagagc cagaggctgc     2100

agaaccctgg gcctgcccgc cctgctgctg ctgctgctgc tgagaccccc cgccaccaga     2160

ggcatcacct gccccccccc catgagcgtg gagcacgccg acatctgggt gaagagctac     2220

agcctgtaca gcagagagag atacatctgc aacagcggct tcaagagaaa ggccggcacc     2280

agcagcctga ccgagtgcgt gctgaacaag gccaccaacg tggcccactg gaccaccccc     2340

agcctgaagt gcatcagata agtttaaac                                       2369


<210>  46
<211>  786
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  46

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Asp Val Val Met Thr Gln Ser His Arg Phe Met 
            20                  25                  30          


Ser Thr Ser Val Gly Asp Arg Val Ser Ile Thr Cys Arg Ala Ser Gln 
        35                  40                  45              


Asp Val Asn Thr Ala Val Ser Trp Tyr Gln Gln Lys Pro Gly Gln Ser 
    50                  55                  60                  


Pro Lys Leu Leu Ile Phe Ser Ala Ser Tyr Arg Tyr Thr Gly Val Pro 
65                  70                  75                  80  


Asp Arg Phe Thr Gly Ser Gly Ser Gly Ala Asp Phe Thr Leu Thr Ile 
                85                  90                  95      


Ser Ser Val Gln Ala Glu Asp Leu Ala Val Tyr Tyr Cys Gln Gln His 
            100                 105                 110         


Tyr Ser Thr Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Asp Ile Lys 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln 
    130                 135                 140                 


Ile Gln Leu Val Gln Ser Gly Pro Asp Leu Lys Lys Pro Gly Glu Thr 
145                 150                 155                 160 


Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Phe Gly 
                165                 170                 175     


Met Asn Trp Val Lys Gln Ala Pro Gly Lys Gly Phe Lys Trp Met Ala 
            180                 185                 190         


Trp Ile Asn Thr Thr Arg Tyr Thr Gly Glu Ser Tyr Phe Ala Asp Asp 
        195                 200                 205             


Phe Lys Gly Arg Phe Ala Phe Ser Val Glu Thr Ser Ala Thr Thr Ala 
    210                 215                 220                 


Tyr Leu Gln Ile Asn Asn Leu Lys Thr Glu Asp Thr Ala Thr Tyr Phe 
225                 230                 235                 240 


Cys Ala Arg Gly Glu Ile Tyr Tyr Gly Tyr Asp Gly Gly Phe Ala Tyr 
                245                 250                 255     


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ala Thr Thr Thr Pro Ala 
            260                 265                 270         


Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser 
        275                 280                 285             


Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr 
    290                 295                 300                 


Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala 
305                 310                 315                 320 


Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys 
                325                 330                 335     


Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met 
            340                 345                 350         


Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe 
        355                 360                 365             


Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg 
    370                 375                 380                 


Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn 
385                 390                 395                 400 


Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg 
                405                 410                 415     


Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Gln Arg Arg Lys Asn 
            420                 425                 430         


Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu 
        435                 440                 445             


Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly 
    450                 455                 460                 


His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr 
465                 470                 475                 480 


Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg Gly Ser Gly Ala Thr 
                485                 490                 495     


Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly 
            500                 505                 510         


Pro Met Tyr Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala 
        515                 520                 525             


Leu Val Thr Asn Ser Gly Ile His Val Phe Ile Leu Gly Cys Phe Ser 
    530                 535                 540                 


Ala Gly Leu Pro Lys Thr Glu Ala Asn Trp Val Asn Val Ile Ser Asp 
545                 550                 555                 560 


Leu Lys Lys Ile Glu Asp Leu Ile Gln Ser Met His Ile Asp Ala Thr 
                565                 570                 575     


Leu Tyr Thr Glu Ser Asp Val His Pro Ser Cys Lys Val Thr Ala Met 
            580                 585                 590         


Lys Cys Phe Leu Leu Glu Leu Gln Val Ile Ser Leu Glu Ser Gly Asp 
        595                 600                 605             


Ala Ser Ile His Asp Thr Val Glu Asn Leu Ile Ile Leu Ala Asn Asn 
    610                 615                 620                 


Ser Leu Ser Ser Asn Gly Asn Val Thr Glu Ser Gly Cys Lys Glu Cys 
625                 630                 635                 640 


Glu Glu Leu Glu Glu Lys Asn Ile Lys Glu Phe Leu Gln Ser Phe Val 
                645                 650                 655     


His Ile Val Gln Met Phe Ile Asn Thr Ser Ser Gly Gly Gly Ser Gly 
            660                 665                 670         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
        675                 680                 685             


Gly Ser Leu Gln Ala Pro Arg Arg Ala Arg Gly Cys Arg Thr Leu Gly 
    690                 695                 700                 


Leu Pro Ala Leu Leu Leu Leu Leu Leu Leu Arg Pro Pro Ala Thr Arg 
705                 710                 715                 720 


Gly Ile Thr Cys Pro Pro Pro Met Ser Val Glu His Ala Asp Ile Trp 
                725                 730                 735     


Val Lys Ser Tyr Ser Leu Tyr Ser Arg Glu Arg Tyr Ile Cys Asn Ser 
            740                 745                 750         


Gly Phe Lys Arg Lys Ala Gly Thr Ser Ser Leu Thr Glu Cys Val Leu 
        755                 760                 765             


Asn Lys Ala Thr Asn Val Ala His Trp Thr Thr Pro Ser Leu Lys Cys 
    770                 775                 780                 


Ile Arg 
785     


<210>  47
<211>  3019
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  47
gcgatcgcac catggcctta ccagtgaccg ccttgctcct gccgctggcc ttgctgctcc       60

acgccgccag gccggatgtg gtgatgaccc agagccatcg ctttatgagc accagcgtgg      120

gcgaccgagt gagcattacc tgccgcgcga gccaggatgt gaacaccgcg gtgagctggt      180

atcagcagaa accgggccag agcccgaaac tgctgatttt tagcgcgagc tatcgctata      240

ccggcgtgcc ggatcgcttt accggcagcg gcagcggcgc ggattttacc ctgaccatta      300

gcagcgtgca ggcggaagat ctggcggtgt attattgcca gcagcattat agcaccccgt      360

ggacctttgg cggcggcacc aaactggaca ttaaaggagg ggggggatcc gggggaggag      420

gctccggcgg aggcggaagc cagattcagc tggtgcagag cggcccggat ctgaaaaaac      480

cgggcgaaac cgtgaaactg agctgcaaag cgagcggcta tacctttacc aactttggca      540

tgaactgggt gaaacaggcg ccgggcaaag gctttaaatg gatggcgtgg attaacacca      600

cccgctatac cggcgaaagc tattttgcgg atgattttaa aggccgcttt gcgtttagcg      660

tggaaaccag cgcgaccacc gcgtatctgc agattaacaa cctgaaaacc gaagataccg      720

cgacctattt ttgcgcgcgc ggcgaaattt attatggcta tgatggcggc tttgcgtatt      780

ggggccaggg caccctggtg accgtgagcg cgaccacgac gccagcgccg cgaccaccaa      840

caccggcgcc caccatcgcg tcgcagcccc tgtccctgcg cccagaggcg tgccggccag      900

cggcgggggg cgcagtgcac acgagggggc tggacttcgc ctgtgatatc tacatctggg      960

cgcccttggc cgggacttgt ggggtccttc tcctgtcact ggttatcacc ctttactgca     1020

aacggggcag aaagaaactc ctgtatatat tcaaacaacc atttatgaga ccagtacaaa     1080

ctactcaaga ggaagatggc tgtagctgcc gatttccaga agaagaagaa ggaggatgtg     1140

aactgagagt gaagttcagc aggagcgcag acgcccccgc gtaccagcag ggccagaacc     1200

agctctataa cgagctcaat ctaggacgaa gagaggagta cgatgttttg gacaagagac     1260

gtggccggga ccctgagatg gggggaaagc cgcagagaag gaagaaccct caggaaggcc     1320

tgtacaatga actgcagaaa gataagatgg cggaggccta cagtgagatt gggatgaaag     1380

gcgagcgccg gaggggcaag gggcacgatg gcctttacca gggtctcagt acagccacca     1440

aggacaccta cgacgccctt cacatgcagg ccctgccccc tcgcggaagc ggagccacca     1500

acttcagcct gctgaagcag gccggcgacg tggaggagaa ccccggcccc atggccctgc     1560

ccgtgaccgc cctgctgctg cccctggccc tgctgctgca cgccgccagg cccgatattc     1620

agatgaccca gagcccgagc agcctgagcg cgagcgtggg cgaccgggtg accattacct     1680

gcaaagcgag ccaggatgtg ggcattgcgg tggcgtggta tcagcagaaa ccgggcaaag     1740

tgccgaaact gctgatttat tgggcgagca cccgccatac cggcgtgccg gatcgcttta     1800

gcggcagcgg cagcggcacc gattttaccc tgaccattag cagcctgcag ccggaagatg     1860

tggcgaccta ttattgccag cagtatagca gctatccgta tacctttggc cagggcacca     1920

aagtggaaat taaaggaggg gggggatccg ggggaggagg ctccggcgga ggcggaagcg     1980

aagtgcagct ggtggaaagc ggcggcggcc tggtgcagcc gggcggcagc ctgcgcctga     2040

gctgcgcggc gagcggcttt gattttagcc gctattggat gagctgggtg cgccaggcgc     2100

cgggcaaagg cctggaatgg attggcgaaa ttaacccgga tagcagcacc attaactatg     2160

cgccgagcct gaaagataaa tttattatta gccgcgataa cgcgaaaaac agcctgtatc     2220

tgcagatgaa cagcctgcgc gcggaagata ccgcggtgta ttattgcgcg cgcccggatg     2280

gcaactattg gtattttgat gtgtggggcc agggcaccct ggtgaccgtg agcagcacca     2340

ccacccccgc ccccaggccc cccacccccg cccccaccat cgccagccag cccctgagcc     2400

tgaggcccga ggcctgcagg cccgccgccg gcggcgccgt gcacaccagg ggcctggact     2460

tcgcctgcga catctacatc tgggcccccc tggccggcac ctgcggcgtg ctgctgctga     2520

gcctggtgat caccctgtac tgcaagaggg gcaggaagaa gctgctgtac atcttcaagc     2580

agcccttcat gaggcccgtg cagaccaccc aggaggagga cggctgcagc tgcaggttcc     2640

ccgaggagga ggagggcggc tgcgagctga gggtgaagtt cagcaggagc gccgacgccc     2700

ccgcctacca gcagggccag aaccagctgt acaacgagct gaacctgggc aggagggagg     2760

agtacgacgt gctggacaag aggaggggca gggaccccga gatgggcggc aagccccaga     2820

ggaggaagaa cccccaggag ggcctgtaca acgagctgca gaaggacaag atggccgagg     2880

cctacagcga gatcggcatg aagggcgaga ggaggagggg caagggccac gacggcctgt     2940

accagggcct gagcaccgcc accaaggaca cctacgacgc cctgcacatg caggccctgc     3000

cccccaggta agtttaaac                                                  3019


<210>  48
<211>  999
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  48

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Asp Val Val Met Thr Gln Ser His Arg Phe Met 
            20                  25                  30          


Ser Thr Ser Val Gly Asp Arg Val Ser Ile Thr Cys Arg Ala Ser Gln 
        35                  40                  45              


Asp Val Asn Thr Ala Val Ser Trp Tyr Gln Gln Lys Pro Gly Gln Ser 
    50                  55                  60                  


Pro Lys Leu Leu Ile Phe Ser Ala Ser Tyr Arg Tyr Thr Gly Val Pro 
65                  70                  75                  80  


Asp Arg Phe Thr Gly Ser Gly Ser Gly Ala Asp Phe Thr Leu Thr Ile 
                85                  90                  95      


Ser Ser Val Gln Ala Glu Asp Leu Ala Val Tyr Tyr Cys Gln Gln His 
            100                 105                 110         


Tyr Ser Thr Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Asp Ile Lys 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln 
    130                 135                 140                 


Ile Gln Leu Val Gln Ser Gly Pro Asp Leu Lys Lys Pro Gly Glu Thr 
145                 150                 155                 160 


Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Phe Gly 
                165                 170                 175     


Met Asn Trp Val Lys Gln Ala Pro Gly Lys Gly Phe Lys Trp Met Ala 
            180                 185                 190         


Trp Ile Asn Thr Thr Arg Tyr Thr Gly Glu Ser Tyr Phe Ala Asp Asp 
        195                 200                 205             


Phe Lys Gly Arg Phe Ala Phe Ser Val Glu Thr Ser Ala Thr Thr Ala 
    210                 215                 220                 


Tyr Leu Gln Ile Asn Asn Leu Lys Thr Glu Asp Thr Ala Thr Tyr Phe 
225                 230                 235                 240 


Cys Ala Arg Gly Glu Ile Tyr Tyr Gly Tyr Asp Gly Gly Phe Ala Tyr 
                245                 250                 255     


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ala Thr Thr Thr Pro Ala 
            260                 265                 270         


Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser 
        275                 280                 285             


Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr 
    290                 295                 300                 


Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala 
305                 310                 315                 320 


Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys 
                325                 330                 335     


Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met 
            340                 345                 350         


Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe 
        355                 360                 365             


Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg 
    370                 375                 380                 


Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn 
385                 390                 395                 400 


Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg 
                405                 410                 415     


Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Gln Arg Arg Lys Asn 
            420                 425                 430         


Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu 
        435                 440                 445             


Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly 
    450                 455                 460                 


His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr 
465                 470                 475                 480 


Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg Gly Ser Gly Ala Thr 
                485                 490                 495     


Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly 
            500                 505                 510         


Pro Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu 
        515                 520                 525             


Leu His Ala Ala Arg Pro Asp Ile Gln Met Thr Gln Ser Pro Ser Ser 
    530                 535                 540                 


Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Lys Ala Ser 
545                 550                 555                 560 


Gln Asp Val Gly Ile Ala Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys 
                565                 570                 575     


Val Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg His Thr Gly Val 
            580                 585                 590         


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
        595                 600                 605             


Ile Ser Ser Leu Gln Pro Glu Asp Val Ala Thr Tyr Tyr Cys Gln Gln 
    610                 615                 620                 


Tyr Ser Ser Tyr Pro Tyr Thr Phe Gly Gln Gly Thr Lys Val Glu Ile 
625                 630                 635                 640 


Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
                645                 650                 655     


Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
            660                 665                 670         


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asp Phe Ser Arg Tyr 
        675                 680                 685             


Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
    690                 695                 700                 


Gly Glu Ile Asn Pro Asp Ser Ser Thr Ile Asn Tyr Ala Pro Ser Leu 
705                 710                 715                 720 


Lys Asp Lys Phe Ile Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
                725                 730                 735     


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
            740                 745                 750         


Ala Arg Pro Asp Gly Asn Tyr Trp Tyr Phe Asp Val Trp Gly Gln Gly 
        755                 760                 765             


Thr Leu Val Thr Val Ser Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro 
    770                 775                 780                 


Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu 
785                 790                 795                 800 


Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp 
                805                 810                 815     


Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly 
            820                 825                 830         


Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg 
        835                 840                 845             


Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln 
    850                 855                 860                 


Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu 
865                 870                 875                 880 


Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala 
                885                 890                 895     


Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu 
            900                 905                 910         


Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp 
        915                 920                 925             


Pro Glu Met Gly Gly Lys Pro Gln Arg Arg Lys Asn Pro Gln Glu Gly 
    930                 935                 940                 


Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu 
945                 950                 955                 960 


Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu 
                965                 970                 975     


Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His 
            980                 985                 990         


Met Gln Ala Leu Pro Pro Arg 
        995                 


<210>  49
<211>  3040
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  49
gcgatcgcac catggcctta ccagtgaccg ccttgctcct gccgctggcc ttgctgctcc       60

acgccgccag gccggatgtg gtgatgaccc agagccatcg ctttatgagc accagcgtgg      120

gcgaccgagt gagcattacc tgccgcgcga gccaggatgt gaacaccgcg gtgagctggt      180

atcagcagaa accgggccag agcccgaaac tgctgatttt tagcgcgagc tatcgctata      240

ccggcgtgcc ggatcgcttt accggcagcg gcagcggcgc ggattttacc ctgaccatta      300

gcagcgtgca ggcggaagat ctggcggtgt attattgcca gcagcattat agcaccccgt      360

ggacctttgg cggcggcacc aaactggaca ttaaaggagg ggggggatcc gggggaggag      420

gctccggcgg aggcggaagc cagattcagc tggtgcagag cggcccggat ctgaaaaaac      480

cgggcgaaac cgtgaaactg agctgcaaag cgagcggcta tacctttacc aactttggca      540

tgaactgggt gaaacaggcg ccgggcaaag gctttaaatg gatggcgtgg attaacacca      600

cccgctatac cggcgaaagc tattttgcgg atgattttaa aggccgcttt gcgtttagcg      660

tggaaaccag cgcgaccacc gcgtatctgc agattaacaa cctgaaaacc gaagataccg      720

cgacctattt ttgcgcgcgc ggcgaaattt attatggcta tgatggcggc tttgcgtatt      780

ggggccaggg caccctggtg accgtgagcg cgaccacgac gccagcgccg cgaccaccaa      840

caccggcgcc caccatcgcg tcgcagcccc tgtccctgcg cccagaggcg tgccggccag      900

cggcgggggg cgcagtgcac acgagggggc tggacttcgc ctgtgatatc tacatctggg      960

cgcccttggc cgggacttgt ggggtccttc tcctgtcact ggttatcacc ctttactgca     1020

aacggggcag aaagaaactc ctgtatatat tcaaacaacc atttatgaga ccagtacaaa     1080

ctactcaaga ggaagatggc tgtagctgcc gatttccaga agaagaagaa ggaggatgtg     1140

aactgagagt gaagttcagc aggagcgcag acgcccccgc gtaccagcag ggccagaacc     1200

agctctataa cgagctcaat ctaggacgaa gagaggagta cgatgttttg gacaagagac     1260

gtggccggga ccctgagatg gggggaaagc cgcagagaag gaagaaccct caggaaggcc     1320

tgtacaatga actgcagaaa gataagatgg cggaggccta cagtgagatt gggatgaaag     1380

gcgagcgccg gaggggcaag gggcacgatg gcctttacca gggtctcagt acagccacca     1440

aggacaccta cgacgccctt cacatgcagg ccctgccccc tcgcggaagc ggagccacca     1500

acttcagcct gctgaagcag gccggcgacg tggaggagaa ccccggcccc atggccctgc     1560

ccgtgaccgc cctgctgctg cccctggccc tgctgctgca cgccgccagg cccgaggtcc     1620

agctgcagca gtctggacct gagctgataa agcctggggc ttcagtgaag atgtcctgca     1680

aggcttctgg atacacattc actagctatg ttatgcactg ggtgaagcag aagcctgggc     1740

agggccttga gtggattgga tatattaatc cttacaatga tggtactaag tacaatgaga     1800

agttcaaagg caaggccaca ctgacttcag acaaatcctc cagcacagcc tacatggagc     1860

tcagcagcct gacctctgag gactctgcgg tctattactg tgcaagaggg acttattact     1920

acggtagtag ggtatttgac tactggggcc aaggcaccac tctcacagtc tcctcaggtg     1980

gagggggctc aggcggaggt ggctctgggg gtggaggctc ggacattgtg atgactcagg     2040

ctgcaccctc tatacctgtc actcctggag agtcagtatc catctcctgc aggtctagta     2100

agagtctcct gaatagtaat ggcaacactt acttgtattg gttcctgcag aggccaggcc     2160

agtctcctca gctcctgata tatcggatgt ccaaccttgc ctcaggagtc ccagacaggt     2220

tcagtggcag tgggtcagga actgctttca cactgagaat cagtagagtg gaggctgagg     2280

atgtgggtgt ttattactgt atgcaacatc tagaatatcc gttcacgttc ggtgctggga     2340

ccaagctgga gctgaaacgg accaccaccc ccgcccccag gccccccacc cccgccccca     2400

ccatcgccag ccagcccctg agcctgaggc ccgaggcctg caggcccgcc gccggcggcg     2460

ccgtgcacac caggggcctg gacttcgcct gcgacatcta catctgggcc cccctggccg     2520

gcacctgcgg cgtgctgctg ctgagcctgg tgatcaccct gtactgcagg agtaagagga     2580

gcaggctcct gcacagtgac tacatgaaca tgactccccg ccgccccggg cccacccgca     2640

agcattacca gccctatgcc ccaccacgcg acttcgcagc ctatcgctcc agggtgaagt     2700

tcagcaggag cgccgacgcc cccgcctacc agcagggcca gaaccagctg tacaacgagc     2760

tgaacctggg caggagggag gagtacgacg tgctggacaa gaggaggggc agggaccccg     2820

agatgggcgg caagccccag aggaggaaga acccccagga gggcctgtac aacgagctgc     2880

agaaggacaa gatggccgag gcctacagcg agatcggcat gaagggcgag aggaggaggg     2940

gcaagggcca cgacggcctg taccagggcc tgagcaccgc caccaaggac acctacgacg     3000

ccctgcacat gcaggccctg ccccccaggt aagtttaaac                           3040


<210>  50
<211>  1006
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  50

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Asp Val Val Met Thr Gln Ser His Arg Phe Met 
            20                  25                  30          


Ser Thr Ser Val Gly Asp Arg Val Ser Ile Thr Cys Arg Ala Ser Gln 
        35                  40                  45              


Asp Val Asn Thr Ala Val Ser Trp Tyr Gln Gln Lys Pro Gly Gln Ser 
    50                  55                  60                  


Pro Lys Leu Leu Ile Phe Ser Ala Ser Tyr Arg Tyr Thr Gly Val Pro 
65                  70                  75                  80  


Asp Arg Phe Thr Gly Ser Gly Ser Gly Ala Asp Phe Thr Leu Thr Ile 
                85                  90                  95      


Ser Ser Val Gln Ala Glu Asp Leu Ala Val Tyr Tyr Cys Gln Gln His 
            100                 105                 110         


Tyr Ser Thr Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Asp Ile Lys 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln 
    130                 135                 140                 


Ile Gln Leu Val Gln Ser Gly Pro Asp Leu Lys Lys Pro Gly Glu Thr 
145                 150                 155                 160 


Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Phe Gly 
                165                 170                 175     


Met Asn Trp Val Lys Gln Ala Pro Gly Lys Gly Phe Lys Trp Met Ala 
            180                 185                 190         


Trp Ile Asn Thr Thr Arg Tyr Thr Gly Glu Ser Tyr Phe Ala Asp Asp 
        195                 200                 205             


Phe Lys Gly Arg Phe Ala Phe Ser Val Glu Thr Ser Ala Thr Thr Ala 
    210                 215                 220                 


Tyr Leu Gln Ile Asn Asn Leu Lys Thr Glu Asp Thr Ala Thr Tyr Phe 
225                 230                 235                 240 


Cys Ala Arg Gly Glu Ile Tyr Tyr Gly Tyr Asp Gly Gly Phe Ala Tyr 
                245                 250                 255     


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ala Thr Thr Thr Pro Ala 
            260                 265                 270         


Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser 
        275                 280                 285             


Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr 
    290                 295                 300                 


Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala 
305                 310                 315                 320 


Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys 
                325                 330                 335     


Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met 
            340                 345                 350         


Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe 
        355                 360                 365             


Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg 
    370                 375                 380                 


Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn 
385                 390                 395                 400 


Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg 
                405                 410                 415     


Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Gln Arg Arg Lys Asn 
            420                 425                 430         


Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu 
        435                 440                 445             


Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly 
    450                 455                 460                 


His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr 
465                 470                 475                 480 


Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg Gly Ser Gly Ala Thr 
                485                 490                 495     


Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly 
            500                 505                 510         


Pro Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu 
        515                 520                 525             


Leu His Ala Ala Arg Pro Glu Val Gln Leu Gln Gln Ser Gly Pro Glu 
    530                 535                 540                 


Leu Ile Lys Pro Gly Ala Ser Val Lys Met Ser Cys Lys Ala Ser Gly 
545                 550                 555                 560 


Tyr Thr Phe Thr Ser Tyr Val Met His Trp Val Lys Gln Lys Pro Gly 
                565                 570                 575     


Gln Gly Leu Glu Trp Ile Gly Tyr Ile Asn Pro Tyr Asn Asp Gly Thr 
            580                 585                 590         


Lys Tyr Asn Glu Lys Phe Lys Gly Lys Ala Thr Leu Thr Ser Asp Lys 
        595                 600                 605             


Ser Ser Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Thr Ser Glu Asp 
    610                 615                 620                 


Ser Ala Val Tyr Tyr Cys Ala Arg Gly Thr Tyr Tyr Tyr Gly Ser Arg 
625                 630                 635                 640 


Val Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser Gly 
                645                 650                 655     


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile 
            660                 665                 670         


Val Met Thr Gln Ala Ala Pro Ser Ile Pro Val Thr Pro Gly Glu Ser 
        675                 680                 685             


Val Ser Ile Ser Cys Arg Ser Ser Lys Ser Leu Leu Asn Ser Asn Gly 
    690                 695                 700                 


Asn Thr Tyr Leu Tyr Trp Phe Leu Gln Arg Pro Gly Gln Ser Pro Gln 
705                 710                 715                 720 


Leu Leu Ile Tyr Arg Met Ser Asn Leu Ala Ser Gly Val Pro Asp Arg 
                725                 730                 735     


Phe Ser Gly Ser Gly Ser Gly Thr Ala Phe Thr Leu Arg Ile Ser Arg 
            740                 745                 750         


Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln His Leu Glu 
        755                 760                 765             


Tyr Pro Phe Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Arg Thr 
    770                 775                 780                 


Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser 
785                 790                 795                 800 


Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly 
                805                 810                 815     


Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp 
            820                 825                 830         


Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile 
        835                 840                 845             


Thr Leu Tyr Cys Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr 
    850                 855                 860                 


Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln 
865                 870                 875                 880 


Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Arg Val Lys 
                885                 890                 895     


Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln 
            900                 905                 910         


Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu 
        915                 920                 925             


Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Gln Arg 
    930                 935                 940                 


Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys 
945                 950                 955                 960 


Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg 
                965                 970                 975     


Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys 
            980                 985                 990         


Asp Thr Tyr Asp Ala Leu His Met  Gln Ala Leu Pro Pro  Arg 
        995                 1000                 1005     


<210>  51
<211>  3022
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  51
gcgatcgcac catggcctta ccagtgaccg ccttgctcct gccgctggcc ttgctgctcc       60

acgccgccag gccggatgtg gtgatgaccc agagccatcg ctttatgagc accagcgtgg      120

gcgaccgagt gagcattacc tgccgcgcga gccaggatgt gaacaccgcg gtgagctggt      180

atcagcagaa accgggccag agcccgaaac tgctgatttt tagcgcgagc tatcgctata      240

ccggcgtgcc ggatcgcttt accggcagcg gcagcggcgc ggattttacc ctgaccatta      300

gcagcgtgca ggcggaagat ctggcggtgt attattgcca gcagcattat agcaccccgt      360

ggacctttgg cggcggcacc aaactggaca ttaaaggagg ggggggatcc gggggaggag      420

gctccggcgg aggcggaagc cagattcagc tggtgcagag cggcccggat ctgaaaaaac      480

cgggcgaaac cgtgaaactg agctgcaaag cgagcggcta tacctttacc aactttggca      540

tgaactgggt gaaacaggcg ccgggcaaag gctttaaatg gatggcgtgg attaacacca      600

cccgctatac cggcgaaagc tattttgcgg atgattttaa aggccgcttt gcgtttagcg      660

tggaaaccag cgcgaccacc gcgtatctgc agattaacaa cctgaaaacc gaagataccg      720

cgacctattt ttgcgcgcgc ggcgaaattt attatggcta tgatggcggc tttgcgtatt      780

ggggccaggg caccctggtg accgtgagcg cgaccacgac gccagcgccg cgaccaccaa      840

caccggcgcc caccatcgcg tcgcagcccc tgtccctgcg cccagaggcg tgccggccag      900

cggcgggggg cgcagtgcac acgagggggc tggacttcgc ctgtgatatc tacatctggg      960

cgcccttggc cgggacttgt ggggtccttc tcctgtcact ggttatcacc ctttactgca     1020

aacggggcag aaagaaactc ctgtatatat tcaaacaacc atttatgaga ccagtacaaa     1080

ctactcaaga ggaagatggc tgtagctgcc gatttccaga agaagaagaa ggaggatgtg     1140

aactgagagt gaagttcagc aggagcgcag acgcccccgc gtaccagcag ggccagaacc     1200

agctctataa cgagctcaat ctaggacgaa gagaggagta cgatgttttg gacaagagac     1260

gtggccggga ccctgagatg gggggaaagc cgcagagaag gaagaaccct caggaaggcc     1320

tgtacaatga actgcagaaa gataagatgg cggaggccta cagtgagatt gggatgaaag     1380

gcgagcgccg gaggggcaag gggcacgatg gcctttacca gggtctcagt acagccacca     1440

aggacaccta cgacgccctt cacatgcagg ccctgccccc tcgcggaagc ggagccacca     1500

acttcagcct gctgaagcag gccggcgacg tggaggagaa ccccggcccc atggccctgc     1560

ccgtgaccgc cctgctgctg cccctggccc tgctgctgca cgccgccagg cccgacatcc     1620

agatgacaca gactacatcc tccctgtctg cctctctggg agacagagtc accatcagtt     1680

gcagggcaag tcaggacatt agtaaatatt taaattggta tcagcagaaa ccagatggaa     1740

ctgttaaact cctgatctac catacatcaa gattacactc aggagtccca tcaaggttca     1800

gtggcagtgg gtctggaaca gattattctc tcaccattag caacctggag caagaagata     1860

ttgccactta cttttgccaa cagggtaata cgcttccgta cacgttcgga ggggggacca     1920

agctggagat cacaggtggc ggtggctcgg gcggtggtgg gtcgggtggc ggcggatctg     1980

aggtgaaact gcaggagtca ggacctggcc tggtggcgcc ctcacagagc ctgtccgtca     2040

catgcactgt ctcaggggtc tcattacccg actatggtgt aagctggatt cgccagcctc     2100

cacgaaaggg tctggagtgg ctgggagtaa tatggggtag tgaaaccaca tactataatt     2160

cagctctcaa atccagactg accatcatca aggacaactc caagagccaa gttttcttaa     2220

aaatgaacag tctgcaaact gatgacacag ccatttacta ctgtgccaaa cattattact     2280

acggtggtag ctatgctatg gactactggg gccaaggaac ctcagtcacc gtctcctcaa     2340

ccaccacccc cgcccccagg ccccccaccc ccgcccccac catcgccagc cagcccctga     2400

gcctgaggcc cgaggcctgc aggcccgccg ccggcggcgc cgtgcacacc aggggcctgg     2460

acttcgcctg cgacatctac atctgggccc ccctggccgg cacctgcggc gtgctgctgc     2520

tgagcctggt gatcaccctg tactgcaaga ggggcaggaa gaagctgctg tacatcttca     2580

agcagccctt catgaggccc gtgcagacca cccaggagga ggacggctgc agctgcaggt     2640

tccccgagga ggaggagggc ggctgcgagc tgagggtgaa gttcagcagg agcgccgacg     2700

cccccgccta ccagcagggc cagaaccagc tgtacaacga gctgaacctg ggcaggaggg     2760

aggagtacga cgtgctggac aagaggaggg gcagggaccc cgagatgggc ggcaagcccc     2820

agaggaggaa gaacccccag gagggcctgt acaacgagct gcagaaggac aagatggccg     2880

aggcctacag cgagatcggc atgaagggcg agaggaggag gggcaagggc cacgacggcc     2940

tgtaccaggg cctgagcacc gccaccaagg acacctacga cgccctgcac atgcaggccc     3000

tgccccccag gtaagtttaa ac                                              3022


<210>  52
<211>  1000
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  52

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Asp Val Val Met Thr Gln Ser His Arg Phe Met 
            20                  25                  30          


Ser Thr Ser Val Gly Asp Arg Val Ser Ile Thr Cys Arg Ala Ser Gln 
        35                  40                  45              


Asp Val Asn Thr Ala Val Ser Trp Tyr Gln Gln Lys Pro Gly Gln Ser 
    50                  55                  60                  


Pro Lys Leu Leu Ile Phe Ser Ala Ser Tyr Arg Tyr Thr Gly Val Pro 
65                  70                  75                  80  


Asp Arg Phe Thr Gly Ser Gly Ser Gly Ala Asp Phe Thr Leu Thr Ile 
                85                  90                  95      


Ser Ser Val Gln Ala Glu Asp Leu Ala Val Tyr Tyr Cys Gln Gln His 
            100                 105                 110         


Tyr Ser Thr Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Asp Ile Lys 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln 
    130                 135                 140                 


Ile Gln Leu Val Gln Ser Gly Pro Asp Leu Lys Lys Pro Gly Glu Thr 
145                 150                 155                 160 


Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Phe Gly 
                165                 170                 175     


Met Asn Trp Val Lys Gln Ala Pro Gly Lys Gly Phe Lys Trp Met Ala 
            180                 185                 190         


Trp Ile Asn Thr Thr Arg Tyr Thr Gly Glu Ser Tyr Phe Ala Asp Asp 
        195                 200                 205             


Phe Lys Gly Arg Phe Ala Phe Ser Val Glu Thr Ser Ala Thr Thr Ala 
    210                 215                 220                 


Tyr Leu Gln Ile Asn Asn Leu Lys Thr Glu Asp Thr Ala Thr Tyr Phe 
225                 230                 235                 240 


Cys Ala Arg Gly Glu Ile Tyr Tyr Gly Tyr Asp Gly Gly Phe Ala Tyr 
                245                 250                 255     


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ala Thr Thr Thr Pro Ala 
            260                 265                 270         


Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser 
        275                 280                 285             


Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr 
    290                 295                 300                 


Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala 
305                 310                 315                 320 


Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys 
                325                 330                 335     


Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met 
            340                 345                 350         


Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe 
        355                 360                 365             


Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg 
    370                 375                 380                 


Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn 
385                 390                 395                 400 


Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg 
                405                 410                 415     


Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Gln Arg Arg Lys Asn 
            420                 425                 430         


Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu 
        435                 440                 445             


Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly 
    450                 455                 460                 


His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr 
465                 470                 475                 480 


Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg Gly Ser Gly Ala Thr 
                485                 490                 495     


Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly 
            500                 505                 510         


Pro Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu 
        515                 520                 525             


Leu His Ala Ala Arg Pro Asp Ile Gln Met Thr Gln Thr Thr Ser Ser 
    530                 535                 540                 


Leu Ser Ala Ser Leu Gly Asp Arg Val Thr Ile Ser Cys Arg Ala Ser 
545                 550                 555                 560 


Gln Asp Ile Ser Lys Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly 
                565                 570                 575     


Thr Val Lys Leu Leu Ile Tyr His Thr Ser Arg Leu His Ser Gly Val 
            580                 585                 590         


Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr 
        595                 600                 605             


Ile Ser Asn Leu Glu Gln Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln 
    610                 615                 620                 


Gly Asn Thr Leu Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile 
625                 630                 635                 640 


Thr Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
                645                 650                 655     


Glu Val Lys Leu Gln Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln 
            660                 665                 670         


Ser Leu Ser Val Thr Cys Thr Val Ser Gly Val Ser Leu Pro Asp Tyr 
        675                 680                 685             


Gly Val Ser Trp Ile Arg Gln Pro Pro Arg Lys Gly Leu Glu Trp Leu 
    690                 695                 700                 


Gly Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr Asn Ser Ala Leu Lys 
705                 710                 715                 720 


Ser Arg Leu Thr Ile Ile Lys Asp Asn Ser Lys Ser Gln Val Phe Leu 
                725                 730                 735     


Lys Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Ile Tyr Tyr Cys Ala 
            740                 745                 750         


Lys His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln 
        755                 760                 765             


Gly Thr Ser Val Thr Val Ser Ser Thr Thr Thr Pro Ala Pro Arg Pro 
    770                 775                 780                 


Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro 
785                 790                 795                 800 


Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu 
                805                 810                 815     


Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys 
            820                 825                 830         


Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly 
        835                 840                 845             


Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val 
    850                 855                 860                 


Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu 
865                 870                 875                 880 


Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp 
                885                 890                 895     


Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn 
            900                 905                 910         


Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg 
        915                 920                 925             


Asp Pro Glu Met Gly Gly Lys Pro Gln Arg Arg Lys Asn Pro Gln Glu 
    930                 935                 940                 


Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser 
945                 950                 955                 960 


Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly 
                965                 970                 975     


Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu 
            980                 985                 990         


His Met Gln Ala Leu Pro Pro Arg  
        995                 1000 


<210>  53
<211>  1483
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  53
gcgatcgcac catggccctg cccgtgaccg ccctgctgct gcccctggcc ctgctgctgc       60

acgccgccag gcccgacatc cagatgacac agactacatc ctccctgtct gcctctctgg      120

gagacagagt caccatcagt tgcagggcaa gtcaggacat tagtaaatat ttaaattggt      180

atcagcagaa accagatgga actgttaaac tcctgatcta ccatacatca agattacact      240

caggagtccc atcaaggttc agtggcagtg ggtctggaac agattattct ctcaccatta      300

gcaacctgga gcaagaagat attgccactt acttttgcca acagggtaat acgcttccgt      360

acacgttcgg aggggggacc aagctggaga tcacaggtgg cggtggctcg ggcggtggtg      420

ggtcgggtgg cggcggatct gaggtgaaac tgcaggagtc aggacctggc ctggtggcgc      480

cctcacagag cctgtccgtc acatgcactg tctcaggggt ctcattaccc gactatggtg      540

taagctggat tcgccagcct ccacgaaagg gtctggagtg gctgggagta atatggggta      600

gtgaaaccac atactataat tcagctctca aatccagact gaccatcatc aaggacaact      660

ccaagagcca agttttctta aaaatgaaca gtctgcaaac tgatgacaca gccatttact      720

actgtgccaa acattattac tacggtggta gctatgctat ggactactgg ggccaaggaa      780

cctcagtcac cgtctcctca accacgacgc cagcgccgcg accaccaaca ccggcgccca      840

ccatcgcgtc gcagcccctg tccctgcgcc cagaggcgtg ccggccagcg gcggggggcg      900

cagtgcacac gagggggctg gacttcgcct gtgatatcta catctgggcg cccttggccg      960

ggacttgtgg ggtccttctc ctgtcactgg ttatcaccct ttactgcaaa cggggcagaa     1020

agaaactcct gtatatattc aaacaaccat ttatgagacc agtacaaact actcaagagg     1080

aagatggctg tagctgccga tttccagaag aagaagaagg aggatgtgaa ctgagagtga     1140

agttcagcag gagcgcagac gcccccgcgt accagcaggg ccagaaccag ctctataacg     1200

agctcaatct aggacgaaga gaggagtacg atgttttgga caagagacgt ggccgggacc     1260

ctgagatggg gggaaagccg cagagaagga agaaccctca ggaaggcctg tacaatgaac     1320

tgcagaaaga taagatggcg gaggcctaca gtgagattgg gatgaaaggc gagcgccgga     1380

ggggcaaggg gcacgatggc ctttaccagg gtctcagtac agccaccaag gacacctacg     1440

acgcccttca catgcaggcc ctgccccctc gctaagttta aac                       1483


<210>  54
<211>  487
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  54

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu 
            20                  25                  30          


Ser Ala Ser Leu Gly Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln 
        35                  40                  45              


Asp Ile Ser Lys Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr 
    50                  55                  60                  


Val Lys Leu Leu Ile Tyr His Thr Ser Arg Leu His Ser Gly Val Pro 
65                  70                  75                  80  


Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile 
                85                  90                  95      


Ser Asn Leu Glu Gln Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly 
            100                 105                 110         


Asn Thr Leu Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Thr 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu 
    130                 135                 140                 


Val Lys Leu Gln Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln Ser 
145                 150                 155                 160 


Leu Ser Val Thr Cys Thr Val Ser Gly Val Ser Leu Pro Asp Tyr Gly 
                165                 170                 175     


Val Ser Trp Ile Arg Gln Pro Pro Arg Lys Gly Leu Glu Trp Leu Gly 
            180                 185                 190         


Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr Asn Ser Ala Leu Lys Ser 
        195                 200                 205             


Arg Leu Thr Ile Ile Lys Asp Asn Ser Lys Ser Gln Val Phe Leu Lys 
    210                 215                 220                 


Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Ile Tyr Tyr Cys Ala Lys 
225                 230                 235                 240 


His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly 
                245                 250                 255     


Thr Ser Val Thr Val Ser Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro 
            260                 265                 270         


Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu 
        275                 280                 285             


Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp 
    290                 295                 300                 


Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly 
305                 310                 315                 320 


Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg 
                325                 330                 335     


Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln 
            340                 345                 350         


Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu 
        355                 360                 365             


Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala 
    370                 375                 380                 


Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu 
385                 390                 395                 400 


Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp 
                405                 410                 415     


Pro Glu Met Gly Gly Lys Pro Gln Arg Arg Lys Asn Pro Gln Glu Gly 
            420                 425                 430         


Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu 
        435                 440                 445             


Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu 
    450                 455                 460                 


Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His 
465                 470                 475                 480 


Met Gln Ala Leu Pro Pro Arg 
                485         


<210>  55
<211>  1501
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  55
gcgatcgcat ggccttacca gtgaccgcct tgctcctgcc gctggccttg ctgctccacg       60

ccgccaggcc ggaggtccag ctgcagcagt ctggacctga gctgataaag cctggggctt      120

cagtgaagat gtcctgcaag gcttctggat acacattcac tagctatgtt atgcactggg      180

tgaagcagaa gcctgggcag ggccttgagt ggattggata tattaatcct tacaatgatg      240

gtactaagta caatgagaag ttcaaaggca aggccacact gacttcagac aaatcctcca      300

gcacagccta catggagctc agcagcctga cctctgagga ctctgcggtc tattactgtg      360

caagagggac ttattactac ggtagtaggg tatttgacta ctggggccaa ggcaccactc      420

tcacagtctc ctcaggtgga gggggctcag gcggaggtgg ctctgggggt ggaggctcgg      480

acattgtgat gactcaggct gcaccctcta tacctgtcac tcctggagag tcagtatcca      540

tctcctgcag gtctagtaag agtctcctga atagtaatgg caacacttac ttgtattggt      600

tcctgcagag gccaggccag tctcctcagc tcctgatata tcggatgtcc aaccttgcct      660

caggagtccc agacaggttc agtggcagtg ggtcaggaac tgctttcaca ctgagaatca      720

gtagagtgga ggctgaggat gtgggtgttt attactgtat gcaacatcta gaatatccgt      780

tcacgttcgg tgctgggacc aagctggagc tgaaacggac cacgacgcca gcgccgcgac      840

caccaacacc ggcgcccacc atcgcgtcgc agcccctgtc cctgcgccca gaggcgtgcc      900

ggccagcggc ggggggcgca gtgcacacga gggggctgga cttcgcctgt gatatctaca      960

tctgggcgcc cttggccggg acttgtgggg tccttctcct gtcactggtt atcacccttt     1020

actgcaaacg gggcagaaag aaactcctgt atatattcaa acaaccattt atgagaccag     1080

tacaaactac tcaagaggaa gatggctgta gctgccgatt tccagaagaa gaagaaggag     1140

gatgtgaact gagagtgaag ttcagcagga gcgcagacgc ccccgcgtac cagcagggcc     1200

agaaccagct ctataacgag ctcaatctag gacgaagaga ggagtacgat gttttggaca     1260

agagacgtgg ccgggaccct gagatggggg gaaagccgca gagaaggaag aaccctcagg     1320

aaggcctgta caatgaactg cagaaagata agatggcgga ggcctacagt gagattggga     1380

tgaaaggcga gcgccggagg ggcaaggggc acgatggcct ttaccagggt ctcagtacag     1440

ccaccaagga cacctacgac gcccttcaca tgcaggccct gccccctcgc taagtttaaa     1500

c                                                                     1501


<210>  56
<211>  494
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  56

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu 
            20                  25                  30          


Ile Lys Pro Gly Ala Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr 
        35                  40                  45              


Thr Phe Thr Ser Tyr Val Met His Trp Val Lys Gln Lys Pro Gly Gln 
    50                  55                  60                  


Gly Leu Glu Trp Ile Gly Tyr Ile Asn Pro Tyr Asn Asp Gly Thr Lys 
65                  70                  75                  80  


Tyr Asn Glu Lys Phe Lys Gly Lys Ala Thr Leu Thr Ser Asp Lys Ser 
                85                  90                  95      


Ser Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Thr Ser Glu Asp Ser 
            100                 105                 110         


Ala Val Tyr Tyr Cys Ala Arg Gly Thr Tyr Tyr Tyr Gly Ser Arg Val 
        115                 120                 125             


Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val 
145                 150                 155                 160 


Met Thr Gln Ala Ala Pro Ser Ile Pro Val Thr Pro Gly Glu Ser Val 
                165                 170                 175     


Ser Ile Ser Cys Arg Ser Ser Lys Ser Leu Leu Asn Ser Asn Gly Asn 
            180                 185                 190         


Thr Tyr Leu Tyr Trp Phe Leu Gln Arg Pro Gly Gln Ser Pro Gln Leu 
        195                 200                 205             


Leu Ile Tyr Arg Met Ser Asn Leu Ala Ser Gly Val Pro Asp Arg Phe 
    210                 215                 220                 


Ser Gly Ser Gly Ser Gly Thr Ala Phe Thr Leu Arg Ile Ser Arg Val 
225                 230                 235                 240 


Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln His Leu Glu Tyr 
                245                 250                 255     


Pro Phe Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Arg Thr Thr 
            260                 265                 270         


Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln 
        275                 280                 285             


Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala 
    290                 295                 300                 


Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala 
305                 310                 315                 320 


Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr 
                325                 330                 335     


Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln 
            340                 345                 350         


Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser 
        355                 360                 365             


Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys 
    370                 375                 380                 


Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln 
385                 390                 395                 400 


Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu 
                405                 410                 415     


Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Gln Arg 
            420                 425                 430         


Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys 
        435                 440                 445             


Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg 
    450                 455                 460                 


Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys 
465                 470                 475                 480 


Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
                485                 490                 


<210>  57
<211>  2293
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  57
gcgatcgcac catggccctg cccgtgaccg ccctgctgct gcccctggcc ctgctgctgc       60

acgccgccag gcccgacatt cagctgaccc agtctccagc aatcctttct gcatctccag      120

gggagaaggt cacaatgact tgcagggcca gctcaagttt aagtttcatg cactggtacc      180

agcagaagcc aggatcctcc cccaaaccct ggatttatgc cacatccaac ctggcttctg      240

gagtccctgc tcgcttcagt ggcagtgggt ctgggacctc ttactctctc acaatcagca      300

cagtggaggc tgaagatgct gcctcttatt tctgccatca gtggagtagt aacccgctca      360

cgttcggtgc tgggaccaag ctggagatca gctcgggcgg cggcggctcg ggcggcggcg      420

gctccggaga cgtcatgggg gtggattctg ggggaggctt agtgcagcct ggagggtccc      480

ggaaactctc ctgtgcagcc cctggattca ctttcagtag ctttgggatg cactgggttc      540

gtcaggctcc agagaagggg ttggagtggg tcgcatacat tagtagtccc agtagtaccc      600

tccactatgc agacagagtg aagggccgat tcaccatctc cagagacaat cccaagaaca      660

ccctgttcct gcaaatgaaa ctaccctcac tatgctatgg actactgggg ccaagggacc      720

acgttcacac caccaccccc gcccccaggc cccccacccc cgcccccacc atcgccagcc      780

agcccctgag cctgaggccc gaggcctgca ggcccgccgc cggcggcgcc gtgcacacca      840

ggggcctgga cttcgcctgc gacatctaca tctgggcccc cctggccggc acctgcggcg      900

tgctgctgct gagcctggtg atcaccctgt actgcaggag taagaggagc aggctcctgc      960

acagtgacta catgaacatg actccccgcc gccccgggcc cacccgcaag cattaccagc     1020

cctatgcccc accacgcgac ttcgcagcct atcgctccag ggtgaagttc agcaggagcg     1080

ccgacgcccc cgcctaccag cagggccaga accagctgta caacgagctg aacctgggca     1140

ggagggagga gtacgacgtg ctggacaaga ggaggggcag ggaccccgag atgggcggca     1200

agccccagag gaggaagaac ccccaggagg gcctgtacaa cgagctgcag aaggacaaga     1260

tggccgaggc ctacagcgag atcggcatga agggcgagag gaggaggggc aagggccacg     1320

acggcctgta ccagggcctg agcaccgcca ccaaggacac ctacgacgcc ctgcacatgc     1380

aggccctgcc ccccagggga agcggagcca ccaacttcag cctgctgaag caggccggcg     1440

acgtggagga gaaccccggc cccatgtaca gaatgcagct gctgagctgc atcgccctga     1500

gcctggccct ggtgaccaac agcggcatcc acgtgttcat cctgggctgc ttcagcgccg     1560

gcctgcccaa gaccgaggcc aactgggtga acgtgatcag cgacctgaag aagatcgagg     1620

acctgatcca gagcatgcac atcgacgcca ccctgtacac cgagagcgac gtgcacccca     1680

gctgcaaggt gaccgccatg aagtgcttcc tgctggagct gcaggtgatc agcctggaga     1740

gcggcgacgc cagcatccac gacaccgtgg agaacctgat catcctggcc aacaacagcc     1800

tgagcagcaa cggcaacgtg accgagagcg gctgcaagga gtgcgaggag ctggaggaga     1860

agaacatcaa ggagttcctg cagagcttcg tgcacatcgt gcagatgttc atcaacacca     1920

gctccggcgg cggctccggc ggcggcggct ccggcggcgg cggctccggc ggcggcggct     1980

ccggcggcgg ctccctgcag gcccccagaa gagccagagg ctgcagaacc ctgggcctgc     2040

ccgccctgct gctgctgctg ctgctgagac cccccgccac cagaggcatc acctgccccc     2100

cccccatgag cgtggagcac gccgacatct gggtgaagag ctacagcctg tacagcagag     2160

agagatacat ctgcaacagc ggcttcaaga gaaaggccgg caccagcagc ctgaccgagt     2220

gcgtgctgaa caaggccacc aacgtggccc actggaccac ccccagcctg aagtgcatca     2280

gataagttta aac                                                        2293


<210>  58
<211>  757
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  58

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Asp Ile Gln Leu Thr Gln Ser Pro Ala Ile Leu 
            20                  25                  30          


Ser Ala Ser Pro Gly Glu Lys Val Thr Met Thr Cys Arg Ala Ser Ser 
        35                  40                  45              


Ser Leu Ser Phe Met His Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro 
    50                  55                  60                  


Lys Pro Trp Ile Tyr Ala Thr Ser Asn Leu Ala Ser Gly Val Pro Ala 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser 
                85                  90                  95      


Thr Val Glu Ala Glu Asp Ala Ala Ser Tyr Phe Cys His Gln Trp Ser 
            100                 105                 110         


Ser Asn Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Ile Ser Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Asp Val Met Gly Val 
    130                 135                 140                 


Asp Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Arg Lys Leu Ser 
145                 150                 155                 160 


Cys Ala Ala Pro Gly Phe Thr Phe Ser Ser Phe Gly Met His Trp Val 
                165                 170                 175     


Arg Gln Ala Pro Glu Lys Gly Leu Glu Trp Val Ala Tyr Ile Ser Ser 
            180                 185                 190         


Pro Ser Ser Thr Leu His Tyr Ala Asp Arg Val Lys Gly Arg Phe Thr 
        195                 200                 205             


Ile Ser Arg Asp Asn Pro Lys Asn Thr Leu Phe Leu Gln Met Lys Leu 
    210                 215                 220                 


Pro Ser Leu Cys Tyr Gly Leu Leu Gly Pro Arg Asp His Val His Thr 
225                 230                 235                 240 


Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser 
                245                 250                 255     


Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly 
            260                 265                 270         


Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp 
        275                 280                 285             


Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile 
    290                 295                 300                 


Thr Leu Tyr Cys Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr 
305                 310                 315                 320 


Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln 
                325                 330                 335     


Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Arg Val Lys 
            340                 345                 350         


Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln 
        355                 360                 365             


Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu 
    370                 375                 380                 


Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Gln Arg 
385                 390                 395                 400 


Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys 
                405                 410                 415     


Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg 
            420                 425                 430         


Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys 
        435                 440                 445             


Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg Gly Ser 
    450                 455                 460                 


Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu 
465                 470                 475                 480 


Asn Pro Gly Pro Met Tyr Arg Met Gln Leu Leu Ser Cys Ile Ala Leu 
                485                 490                 495     


Ser Leu Ala Leu Val Thr Asn Ser Gly Ile His Val Phe Ile Leu Gly 
            500                 505                 510         


Cys Phe Ser Ala Gly Leu Pro Lys Thr Glu Ala Asn Trp Val Asn Val 
        515                 520                 525             


Ile Ser Asp Leu Lys Lys Ile Glu Asp Leu Ile Gln Ser Met His Ile 
    530                 535                 540                 


Asp Ala Thr Leu Tyr Thr Glu Ser Asp Val His Pro Ser Cys Lys Val 
545                 550                 555                 560 


Thr Ala Met Lys Cys Phe Leu Leu Glu Leu Gln Val Ile Ser Leu Glu 
                565                 570                 575     


Ser Gly Asp Ala Ser Ile His Asp Thr Val Glu Asn Leu Ile Ile Leu 
            580                 585                 590         


Ala Asn Asn Ser Leu Ser Ser Asn Gly Asn Val Thr Glu Ser Gly Cys 
        595                 600                 605             


Lys Glu Cys Glu Glu Leu Glu Glu Lys Asn Ile Lys Glu Phe Leu Gln 
    610                 615                 620                 


Ser Phe Val His Ile Val Gln Met Phe Ile Asn Thr Ser Ser Gly Gly 
625                 630                 635                 640 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
                645                 650                 655     


Ser Gly Gly Gly Ser Leu Gln Ala Pro Arg Arg Ala Arg Gly Cys Arg 
            660                 665                 670         


Thr Leu Gly Leu Pro Ala Leu Leu Leu Leu Leu Leu Leu Arg Pro Pro 
        675                 680                 685             


Ala Thr Arg Gly Ile Thr Cys Pro Pro Pro Met Ser Val Glu His Ala 
    690                 695                 700                 


Asp Ile Trp Val Lys Ser Tyr Ser Leu Tyr Ser Arg Glu Arg Tyr Ile 
705                 710                 715                 720 


Cys Asn Ser Gly Phe Lys Arg Lys Ala Gly Thr Ser Ser Leu Thr Glu 
                725                 730                 735     


Cys Val Leu Asn Lys Ala Thr Asn Val Ala His Trp Thr Thr Pro Ser 
            740                 745                 750         


Leu Lys Cys Ile Arg 
        755         


<210>  59
<211>  2389
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  59
gcgatcgcac catggcctta ccagtgaccg ccttgctcct gccgctggcc ttgctgctcc       60

acgccgccag gccggaggtc cagctgcagc agtctggacc tgagctgata aagcctgggg      120

cttcagtgaa gatgtcctgc aaggcttctg gatacacatt cactagctat gttatgcact      180

gggtgaagca gaagcctggg cagggccttg agtggattgg atatattaat ccttacaatg      240

atggtactaa gtacaatgag aagttcaaag gcaaggccac actgacttca gacaaatcct      300

ccagcacagc ctacatggag ctcagcagcc tgacctctga ggactctgcg gtctattact      360

gtgcaagagg gacttattac tacggtagta gggtatttga ctactggggc caaggcacca      420

ctctcacagt ctcctcaggt ggagggggct caggcggagg tggctctggg ggtggaggct      480

cggacattgt gatgactcag gctgcaccct ctatacctgt cactcctgga gagtcagtat      540

ccatctcctg caggtctagt aagagtctcc tgaatagtaa tggcaacact tacttgtatt      600

ggttcctgca gaggccaggc cagtctcctc agctcctgat atatcggatg tccaaccttg      660

cctcaggagt cccagacagg ttcagtggca gtgggtcagg aactgctttc acactgagaa      720

tcagtagagt ggaggctgag gatgtgggtg tttattactg tatgcaacat ctagaatatc      780

cgttcacgtt cggtgctggg accaagctgg agctgaaacg gaccacgacg ccagcgccgc      840

gaccaccaac accggcgccc accatcgcgt cgcagcccct gtccctgcgc ccagaggcgt      900

gccggccagc ggcggggggc gcagtgcaca cgagggggct ggacttcgcc tgtgatatct      960

acatctgggc gcccttggcc gggacttgtg gggtccttct cctgtcactg gttatcaccc     1020

tttactgcaa acggggcaga aagaaactcc tgtatatatt caaacaacca tttatgagac     1080

cagtacaaac tactcaagag gaagatggct gtagctgccg atttccagaa gaagaagaag     1140

gaggatgtga actgagagtg aagttcagca ggagcgcaga cgcccccgcg taccagcagg     1200

gccagaacca gctctataac gagctcaatc taggacgaag agaggagtac gatgttttgg     1260

acaagagacg tggccgggac cctgagatgg ggggaaagcc gcagagaagg aagaaccctc     1320

aggaaggcct gtacaatgaa ctgcagaaag ataagatggc ggaggcctac agtgagattg     1380

ggatgaaagg cgagcgccgg aggggcaagg ggcacgatgg cctttaccag ggtctcagta     1440

cagccaccaa ggacacctac gacgcccttc acatgcaggc cctgccccct cgcggaagcg     1500

gagccaccaa cttcagcctg ctgaagcagg ccggcgacgt ggaggagaac cccggcccca     1560

tgtacagaat gcagctgctg agctgcatcg ccctgagcct ggccctggtg accaacagcg     1620

gcatccacgt gttcatcctg ggctgcttca gcgccggcct gcccaagacc gaggccaact     1680

gggtgaacgt gatcagcgac ctgaagaaga tcgaggacct gatccagagc atgcacatcg     1740

acgccaccct gtacaccgag agcgacgtgc accccagctg caaggtgacc gccatgaagt     1800

gcttcctgct ggagctgcag gtgatcagcc tggagagcgg cgacgccagc atccacgaca     1860

ccgtggagaa cctgatcatc ctggccaaca acagcctgag cagcaacggc aacgtgaccg     1920

agagcggctg caaggagtgc gaggagctgg aggagaagaa catcaaggag ttcctgcaga     1980

gcttcgtgca catcgtgcag atgttcatca acaccagctc cggcggcggc tccggcggcg     2040

gcggctccgg cggcggcggc tccggcggcg gcggctccgg cggcggctcc ctgcaggccc     2100

ccagaagagc cagaggctgc agaaccctgg gcctgcccgc cctgctgctg ctgctgctgc     2160

tgagaccccc cgccaccaga ggcatcacct gccccccccc catgagcgtg gagcacgccg     2220

acatctgggt gaagagctac agcctgtaca gcagagagag atacatctgc aacagcggct     2280

tcaagagaaa ggccggcacc agcagcctga ccgagtgcgt gctgaacaag gccaccaacg     2340

tggcccactg gaccaccccc agcctgaagt gcatcagata agtttaaac                 2389


<210>  60
<211>  789
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  60

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu 
            20                  25                  30          


Ile Lys Pro Gly Ala Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr 
        35                  40                  45              


Thr Phe Thr Ser Tyr Val Met His Trp Val Lys Gln Lys Pro Gly Gln 
    50                  55                  60                  


Gly Leu Glu Trp Ile Gly Tyr Ile Asn Pro Tyr Asn Asp Gly Thr Lys 
65                  70                  75                  80  


Tyr Asn Glu Lys Phe Lys Gly Lys Ala Thr Leu Thr Ser Asp Lys Ser 
                85                  90                  95      


Ser Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Thr Ser Glu Asp Ser 
            100                 105                 110         


Ala Val Tyr Tyr Cys Ala Arg Gly Thr Tyr Tyr Tyr Gly Ser Arg Val 
        115                 120                 125             


Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val 
145                 150                 155                 160 


Met Thr Gln Ala Ala Pro Ser Ile Pro Val Thr Pro Gly Glu Ser Val 
                165                 170                 175     


Ser Ile Ser Cys Arg Ser Ser Lys Ser Leu Leu Asn Ser Asn Gly Asn 
            180                 185                 190         


Thr Tyr Leu Tyr Trp Phe Leu Gln Arg Pro Gly Gln Ser Pro Gln Leu 
        195                 200                 205             


Leu Ile Tyr Arg Met Ser Asn Leu Ala Ser Gly Val Pro Asp Arg Phe 
    210                 215                 220                 


Ser Gly Ser Gly Ser Gly Thr Ala Phe Thr Leu Arg Ile Ser Arg Val 
225                 230                 235                 240 


Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln His Leu Glu Tyr 
                245                 250                 255     


Pro Phe Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Arg Thr Thr 
            260                 265                 270         


Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln 
        275                 280                 285             


Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala 
    290                 295                 300                 


Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala 
305                 310                 315                 320 


Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr 
                325                 330                 335     


Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln 
            340                 345                 350         


Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser 
        355                 360                 365             


Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys 
    370                 375                 380                 


Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln 
385                 390                 395                 400 


Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu 
                405                 410                 415     


Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Gln Arg 
            420                 425                 430         


Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys 
        435                 440                 445             


Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg 
    450                 455                 460                 


Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys 
465                 470                 475                 480 


Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg Gly Ser 
                485                 490                 495     


Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu 
            500                 505                 510         


Asn Pro Gly Pro Met Tyr Arg Met Gln Leu Leu Ser Cys Ile Ala Leu 
        515                 520                 525             


Ser Leu Ala Leu Val Thr Asn Ser Gly Ile His Val Phe Ile Leu Gly 
    530                 535                 540                 


Cys Phe Ser Ala Gly Leu Pro Lys Thr Glu Ala Asn Trp Val Asn Val 
545                 550                 555                 560 


Ile Ser Asp Leu Lys Lys Ile Glu Asp Leu Ile Gln Ser Met His Ile 
                565                 570                 575     


Asp Ala Thr Leu Tyr Thr Glu Ser Asp Val His Pro Ser Cys Lys Val 
            580                 585                 590         


Thr Ala Met Lys Cys Phe Leu Leu Glu Leu Gln Val Ile Ser Leu Glu 
        595                 600                 605             


Ser Gly Asp Ala Ser Ile His Asp Thr Val Glu Asn Leu Ile Ile Leu 
    610                 615                 620                 


Ala Asn Asn Ser Leu Ser Ser Asn Gly Asn Val Thr Glu Ser Gly Cys 
625                 630                 635                 640 


Lys Glu Cys Glu Glu Leu Glu Glu Lys Asn Ile Lys Glu Phe Leu Gln 
                645                 650                 655     


Ser Phe Val His Ile Val Gln Met Phe Ile Asn Thr Ser Ser Gly Gly 
            660                 665                 670         


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        675                 680                 685             


Ser Gly Gly Gly Ser Leu Gln Ala Pro Arg Arg Ala Arg Gly Cys Arg 
    690                 695                 700                 


Thr Leu Gly Leu Pro Ala Leu Leu Leu Leu Leu Leu Leu Arg Pro Pro 
705                 710                 715                 720 


Ala Thr Arg Gly Ile Thr Cys Pro Pro Pro Met Ser Val Glu His Ala 
                725                 730                 735     


Asp Ile Trp Val Lys Ser Tyr Ser Leu Tyr Ser Arg Glu Arg Tyr Ile 
            740                 745                 750         


Cys Asn Ser Gly Phe Lys Arg Lys Ala Gly Thr Ser Ser Leu Thr Glu 
        755                 760                 765             


Cys Val Leu Asn Lys Ala Thr Asn Val Ala His Trp Thr Thr Pro Ser 
    770                 775                 780                 


Leu Lys Cys Ile Arg 
785                 


<210>  61
<211>  2389
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  61
gcgatcgcac catggccctg cccgtgaccg ccctgctgct gcccctggcc ctgctgctgc       60

acgccgccag gcccgatatc cagatgaccc agagccccag ctccctgtcc gcatccgtgg      120

gcgacagagt gacaattacc tgtagaagca gccaaagcat cgtgcatagc gtcggcaaca      180

cttttctgga gtggtatcaa cagaagcccg ggaaggcccc caaactgctg atctacaagg      240

tgagcaacag attcagcggg gtcccaagca gattctccgg cagcggctcc gggactgact      300

tcaccctgac cattagcagc ctgcagccag aggacttcgc cacatactac tgcttccaag      360

ggagccagtt cccctacacc ttcggccaag gcactaaggt ggagatcaaa ggggggggag      420

gaagcggcgg aggagggagc ggaggcgggg gatccgaagt gcaactggtc gaatccggag      480

gggggctggt ccagcctgga gggtccctga gactgagctg cgccgcaagc ggctacgagt      540

tctccaggtc ctggatgaac tgggtgaggc aggccccagg aaaagggctg gaatgggtgg      600

gcaggatcta ccctggcgac ggcgatacca actactccgg aaagttcaag ggcaggttca      660

ctatcagcgc cgacactagc aagaataccg cctacctgca gatgaatagc ctgagggccg      720

aggacaccgc cgtgtattac tgcgctagag acggcagcag ctgggattgg tacttcgacg      780

tgtggggcca gggcactctg gtgactgtga gcagcaccac cacccccgcc cccaggcccc      840

ccacccccgc ccccaccatc gccagccagc ccctgagcct gaggcccgag gcctgcaggc      900

ccgccgccgg cggcgccgtg cacaccaggg gcctggactt cgcctgcgac ttttgggtgc      960

tggtggtggt tggtggagtc ctggcttgct atagcttgct agtaacagtg gcctttatta     1020

ttttctgggt gaggagtaag aggagcaggc tcctgcacag tgactacatg aacatgactc     1080

cccgccgccc cgggcccacc cgcaagcatt accagcccta tgccccacca cgcgacttcg     1140

cagcctatcg ctccagggtg aagttcagca ggagcgccga cgcccccgcc taccagcagg     1200

gccagaacca gctgtacaac gagctgaacc tgggcaggag ggaggagtac gacgtgctgg     1260

acaagaggag gggcagggac cccgagatgg gcggcaagcc ccagaggagg aagaaccccc     1320

aggagggcct gtacaacgag ctgcagaagg acaagatggc cgaggcctac agcgagatcg     1380

gcatgaaggg cgagaggagg aggggcaagg gccacgacgg cctgtaccag ggcctgagca     1440

ccgccaccaa ggacacctac gacgccctgc acatgcaggc cctgcccccc aggggaagcg     1500

gagccaccaa cttcagcctg ctgaagcagg ccggcgacgt ggaggagaac cccggcccca     1560

tgtacagaat gcagctgctg agctgcatcg ccctgagcct ggccctggtg accaacagcg     1620

gcatccacgt gttcatcctg ggctgcttca gcgccggcct gcccaagacc gaggccaact     1680

gggtgaacgt gatcagcgac ctgaagaaga tcgaggacct gatccagagc atgcacatcg     1740

acgccaccct gtacaccgag agcgacgtgc accccagctg caaggtgacc gccatgaagt     1800

gcttcctgct ggagctgcag gtgatcagcc tggagagcgg cgacgccagc atccacgaca     1860

ccgtggagaa cctgatcatc ctggccaaca acagcctgag cagcaacggc aacgtgaccg     1920

agagcggctg caaggagtgc gaggagctgg aggagaagaa catcaaggag ttcctgcaga     1980

gcttcgtgca catcgtgcag atgttcatca acaccagctc cggcggcggc tccggcggcg     2040

gcggctccgg cggcggcggc tccggcggcg gcggctccgg cggcggctcc ctgcaggccc     2100

ccagaagagc cagaggctgc agaaccctgg gcctgcccgc cctgctgctg ctgctgctgc     2160

tgagaccccc cgccaccaga ggcatcacct gccccccccc catgagcgtg gagcacgccg     2220

acatctgggt gaagagctac agcctgtaca gcagagagag atacatctgc aacagcggct     2280

tcaagagaaa ggccggcacc agcagcctga ccgagtgcgt gctgaacaag gccaccaacg     2340

tggcccactg gaccaccccc agcctgaagt gcatcagata agtttaaac                 2389


<210>  62
<211>  789
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  62

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu 
            20                  25                  30          


Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ser Ser Gln 
        35                  40                  45              


Ser Ile Val His Ser Val Gly Asn Thr Phe Leu Glu Trp Tyr Gln Gln 
    50                  55                  60                  


Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg 
65                  70                  75                  80  


Phe Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp 
                85                  90                  95      


Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr 
            100                 105                 110         


Tyr Cys Phe Gln Gly Ser Gln Phe Pro Tyr Thr Phe Gly Gln Gly Thr 
        115                 120                 125             


Lys Val Glu Ile Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val 
145                 150                 155                 160 


Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Glu 
                165                 170                 175     


Phe Ser Arg Ser Trp Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly 
            180                 185                 190         


Leu Glu Trp Val Gly Arg Ile Tyr Pro Gly Asp Gly Asp Thr Asn Tyr 
        195                 200                 205             


Ser Gly Lys Phe Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys 
    210                 215                 220                 


Asn Thr Ala Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala 
225                 230                 235                 240 


Val Tyr Tyr Cys Ala Arg Asp Gly Ser Ser Trp Asp Trp Tyr Phe Asp 
                245                 250                 255     


Val Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Thr Thr Thr Pro 
            260                 265                 270         


Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu 
        275                 280                 285             


Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His 
    290                 295                 300                 


Thr Arg Gly Leu Asp Phe Ala Cys Asp Phe Trp Val Leu Val Val Val 
305                 310                 315                 320 


Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile 
                325                 330                 335     


Ile Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr 
            340                 345                 350         


Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln 
        355                 360                 365             


Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Arg Val Lys 
    370                 375                 380                 


Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln 
385                 390                 395                 400 


Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu 
                405                 410                 415     


Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Gln Arg 
            420                 425                 430         


Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys 
        435                 440                 445             


Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg 
    450                 455                 460                 


Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys 
465                 470                 475                 480 


Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg Gly Ser 
                485                 490                 495     


Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu 
            500                 505                 510         


Asn Pro Gly Pro Met Tyr Arg Met Gln Leu Leu Ser Cys Ile Ala Leu 
        515                 520                 525             


Ser Leu Ala Leu Val Thr Asn Ser Gly Ile His Val Phe Ile Leu Gly 
    530                 535                 540                 


Cys Phe Ser Ala Gly Leu Pro Lys Thr Glu Ala Asn Trp Val Asn Val 
545                 550                 555                 560 


Ile Ser Asp Leu Lys Lys Ile Glu Asp Leu Ile Gln Ser Met His Ile 
                565                 570                 575     


Asp Ala Thr Leu Tyr Thr Glu Ser Asp Val His Pro Ser Cys Lys Val 
            580                 585                 590         


Thr Ala Met Lys Cys Phe Leu Leu Glu Leu Gln Val Ile Ser Leu Glu 
        595                 600                 605             


Ser Gly Asp Ala Ser Ile His Asp Thr Val Glu Asn Leu Ile Ile Leu 
    610                 615                 620                 


Ala Asn Asn Ser Leu Ser Ser Asn Gly Asn Val Thr Glu Ser Gly Cys 
625                 630                 635                 640 


Lys Glu Cys Glu Glu Leu Glu Glu Lys Asn Ile Lys Glu Phe Leu Gln 
                645                 650                 655     


Ser Phe Val His Ile Val Gln Met Phe Ile Asn Thr Ser Ser Gly Gly 
            660                 665                 670         


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        675                 680                 685             


Ser Gly Gly Gly Ser Leu Gln Ala Pro Arg Arg Ala Arg Gly Cys Arg 
    690                 695                 700                 


Thr Leu Gly Leu Pro Ala Leu Leu Leu Leu Leu Leu Leu Arg Pro Pro 
705                 710                 715                 720 


Ala Thr Arg Gly Ile Thr Cys Pro Pro Pro Met Ser Val Glu His Ala 
                725                 730                 735     


Asp Ile Trp Val Lys Ser Tyr Ser Leu Tyr Ser Arg Glu Arg Tyr Ile 
            740                 745                 750         


Cys Asn Ser Gly Phe Lys Arg Lys Ala Gly Thr Ser Ser Leu Thr Glu 
        755                 760                 765             


Cys Val Leu Asn Lys Ala Thr Asn Val Ala His Trp Thr Thr Pro Ser 
    770                 775                 780                 


Leu Lys Cys Ile Arg 
785                 


<210>  63
<211>  3049
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  63
gcgatcgcat ggccttacca gtgaccgcct tgctcctgcc gctggccttg ctgctccacg       60

ccgccaggcc ggaggtccag ctgcagcagt ctggacctga gctgataaag cctggggctt      120

cagtgaagat gtcctgcaag gcttctggat acacattcac tagctatgtt atgcactggg      180

tgaagcagaa gcctgggcag ggccttgagt ggattggata tattaatcct tacaatgatg      240

gtactaagta caatgagaag ttcaaaggca aggccacact gacttcagac aaatcctcca      300

gcacagccta catggagctc agcagcctga cctctgagga ctctgcggtc tattactgtg      360

caagagggac ttattactac ggtagtaggg tatttgacta ctggggccaa ggcaccactc      420

tcacagtctc ctcaggtgga gggggctcag gcggaggtgg ctctgggggt ggaggctcgg      480

acattgtgat gactcaggct gcaccctcta tacctgtcac tcctggagag tcagtatcca      540

tctcctgcag gtctagtaag agtctcctga atagtaatgg caacacttac ttgtattggt      600

tcctgcagag gccaggccag tctcctcagc tcctgatata tcggatgtcc aaccttgcct      660

caggagtccc agacaggttc agtggcagtg ggtcaggaac tgctttcaca ctgagaatca      720

gtagagtgga ggctgaggat gtgggtgttt attactgtat gcaacatcta gaatatccgt      780

tcacgttcgg tgctgggacc aagctggagc tgaaacggac cacgacgcca gcgccgcgac      840

caccaacacc ggcgcccacc atcgcgtcgc agcccctgtc cctgcgccca gaggcgtgcc      900

ggccagcggc ggggggcgca gtgcacacga gggggctgga cttcgcctgt gatatctaca      960

tctgggcgcc cttggccggg acttgtgggg tccttctcct gtcactggtt atcacccttt     1020

actgcaaacg gggcagaaag aaactcctgt atatattcaa acaaccattt atgagaccag     1080

tacaaactac tcaagaggaa gatggctgta gctgccgatt tccagaagaa gaagaaggag     1140

gatgtgaact gagagtgaag ttcagcagga gcgcagacgc ccccgcgtac cagcagggcc     1200

agaaccagct ctataacgag ctcaatctag gacgaagaga ggagtacgat gttttggaca     1260

agagacgtgg ccgggaccct gagatggggg gaaagccgca gagaaggaag aaccctcagg     1320

aaggcctgta caatgaactg cagaaagata agatggcgga ggcctacagt gagattggga     1380

tgaaaggcga gcgccggagg ggcaaggggc acgatggcct ttaccagggt ctcagtacag     1440

ccaccaagga cacctacgac gcccttcaca tgcaggccct gccccctcgc ggaagcggag     1500

ccaccaactt cagcctgctg aagcaggccg gcgacgtgga ggagaacccc ggccccatgg     1560

ccctgcccgt gaccgccctg ctgctgcccc tggccctgct gctgcacgcc gccaggcccg     1620

atatccagat gacccagagc cccagctccc tgtccgcatc cgtgggcgac agagtgacaa     1680

ttacctgtag aagcagccaa agcatcgtgc atagcgtcgg caacactttt ctggagtggt     1740

atcaacagaa gcccgggaag gcccccaaac tgctgatcta caaggtgagc aacagattca     1800

gcggggtccc aagcagattc tccggcagcg gctccgggac tgacttcacc ctgaccatta     1860

gcagcctgca gccagaggac ttcgccacat actactgctt ccaagggagc cagttcccct     1920

acaccttcgg ccaaggcact aaggtggaga tcaaaggggg gggaggaagc ggcggaggag     1980

ggagcggagg cgggggatcc gaagtgcaac tggtcgaatc cggagggggg ctggtccagc     2040

ctggagggtc cctgagactg agctgcgccg caagcggcta cgagttctcc aggtcctgga     2100

tgaactgggt gaggcaggcc ccaggaaaag ggctggaatg ggtgggcagg atctaccctg     2160

gcgacggcga taccaactac tccggaaagt tcaagggcag gttcactatc agcgccgaca     2220

ctagcaagaa taccgcctac ctgcagatga atagcctgag ggccgaggac accgccgtgt     2280

attactgcgc tagagacggc agcagctggg attggtactt cgacgtgtgg ggccagggca     2340

ctctggtgac tgtgagcagc accaccaccc ccgcccccag gccccccacc cccgccccca     2400

ccatcgccag ccagcccctg agcctgaggc ccgaggcctg caggcccgcc gccggcggcg     2460

ccgtgcacac caggggcctg gacttcgcct gcgacttttg ggtgctggtg gtggttggtg     2520

gagtcctggc ttgctatagc ttgctagtaa cagtggcctt tattattttc tgggtgagga     2580

gtaagaggag caggctcctg cacagtgact acatgaacat gactccccgc cgccccgggc     2640

ccacccgcaa gcattaccag ccctatgccc caccacgcga cttcgcagcc tatcgctcca     2700

gggtgaagtt cagcaggagc gccgacgccc ccgcctacca gcagggccag aaccagctgt     2760

acaacgagct gaacctgggc aggagggagg agtacgacgt gctggacaag aggaggggca     2820

gggaccccga gatgggcggc aagccccaga ggaggaagaa cccccaggag ggcctgtaca     2880

acgagctgca gaaggacaag atggccgagg cctacagcga gatcggcatg aagggcgaga     2940

ggaggagggg caagggccac gacggcctgt accagggcct gagcaccgcc accaaggaca     3000

cctacgacgc cctgcacatg caggccctgc cccccaggta agtttaaac                 3049


<210>  64
<211>  1010
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  64

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu 
            20                  25                  30          


Ile Lys Pro Gly Ala Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr 
        35                  40                  45              


Thr Phe Thr Ser Tyr Val Met His Trp Val Lys Gln Lys Pro Gly Gln 
    50                  55                  60                  


Gly Leu Glu Trp Ile Gly Tyr Ile Asn Pro Tyr Asn Asp Gly Thr Lys 
65                  70                  75                  80  


Tyr Asn Glu Lys Phe Lys Gly Lys Ala Thr Leu Thr Ser Asp Lys Ser 
                85                  90                  95      


Ser Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Thr Ser Glu Asp Ser 
            100                 105                 110         


Ala Val Tyr Tyr Cys Ala Arg Gly Thr Tyr Tyr Tyr Gly Ser Arg Val 
        115                 120                 125             


Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val 
145                 150                 155                 160 


Met Thr Gln Ala Ala Pro Ser Ile Pro Val Thr Pro Gly Glu Ser Val 
                165                 170                 175     


Ser Ile Ser Cys Arg Ser Ser Lys Ser Leu Leu Asn Ser Asn Gly Asn 
            180                 185                 190         


Thr Tyr Leu Tyr Trp Phe Leu Gln Arg Pro Gly Gln Ser Pro Gln Leu 
        195                 200                 205             


Leu Ile Tyr Arg Met Ser Asn Leu Ala Ser Gly Val Pro Asp Arg Phe 
    210                 215                 220                 


Ser Gly Ser Gly Ser Gly Thr Ala Phe Thr Leu Arg Ile Ser Arg Val 
225                 230                 235                 240 


Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln His Leu Glu Tyr 
                245                 250                 255     


Pro Phe Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Arg Thr Thr 
            260                 265                 270         


Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln 
        275                 280                 285             


Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala 
    290                 295                 300                 


Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala 
305                 310                 315                 320 


Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr 
                325                 330                 335     


Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln 
            340                 345                 350         


Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser 
        355                 360                 365             


Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys 
    370                 375                 380                 


Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln 
385                 390                 395                 400 


Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu 
                405                 410                 415     


Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Gln Arg 
            420                 425                 430         


Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys 
        435                 440                 445             


Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg 
    450                 455                 460                 


Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys 
465                 470                 475                 480 


Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg Gly Ser 
                485                 490                 495     


Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu 
            500                 505                 510         


Asn Pro Gly Pro Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu 
        515                 520                 525             


Ala Leu Leu Leu His Ala Ala Arg Pro Asp Ile Gln Met Thr Gln Ser 
    530                 535                 540                 


Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys 
545                 550                 555                 560 


Arg Ser Ser Gln Ser Ile Val His Ser Val Gly Asn Thr Phe Leu Glu 
                565                 570                 575     


Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Lys 
            580                 585                 590         


Val Ser Asn Arg Phe Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly 
        595                 600                 605             


Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp 
    610                 615                 620                 


Phe Ala Thr Tyr Tyr Cys Phe Gln Gly Ser Gln Phe Pro Tyr Thr Phe 
625                 630                 635                 640 


Gly Gln Gly Thr Lys Val Glu Ile Lys Gly Gly Gly Gly Ser Gly Gly 
                645                 650                 655     


Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly 
            660                 665                 670         


Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala 
        675                 680                 685             


Ser Gly Tyr Glu Phe Ser Arg Ser Trp Met Asn Trp Val Arg Gln Ala 
    690                 695                 700                 


Pro Gly Lys Gly Leu Glu Trp Val Gly Arg Ile Tyr Pro Gly Asp Gly 
705                 710                 715                 720 


Asp Thr Asn Tyr Ser Gly Lys Phe Lys Gly Arg Phe Thr Ile Ser Ala 
                725                 730                 735     


Asp Thr Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Ser Leu Arg Ala 
            740                 745                 750         


Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Asp Gly Ser Ser Trp Asp 
        755                 760                 765             


Trp Tyr Phe Asp Val Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
    770                 775                 780                 


Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala 
785                 790                 795                 800 


Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly 
                805                 810                 815     


Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Phe Trp Val 
            820                 825                 830         


Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr 
        835                 840                 845             


Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu 
    850                 855                 860                 


His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg 
865                 870                 875                 880 


Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg 
                885                 890                 895     


Ser Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln 
            900                 905                 910         


Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu 
        915                 920                 925             


Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly 
    930                 935                 940                 


Lys Pro Gln Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu 
945                 950                 955                 960 


Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly 
                965                 970                 975     


Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser 
            980                 985                 990         


Thr Ala Thr Lys Asp Thr Tyr Asp  Ala Leu His Met Gln  Ala Leu Pro 
        995                 1000                 1005             


Pro Arg  
    1010 


<210>  65
<211>  2953
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  65
gcgatcgcat ggccttacca gtgaccgcct tgctcctgcc gctggccttg ctgctccacg       60

ccgccaggcc ggaggtccag ctgcagcagt ctggacctga gctgataaag cctggggctt      120

cagtgaagat gtcctgcaag gcttctggat acacattcac tagctatgtt atgcactggg      180

tgaagcagaa gcctgggcag ggccttgagt ggattggata tattaatcct tacaatgatg      240

gtactaagta caatgagaag ttcaaaggca aggccacact gacttcagac aaatcctcca      300

gcacagccta catggagctc agcagcctga cctctgagga ctctgcggtc tattactgtg      360

caagagggac ttattactac ggtagtaggg tatttgacta ctggggccaa ggcaccactc      420

tcacagtctc ctcaggtgga gggggctcag gcggaggtgg ctctgggggt ggaggctcgg      480

acattgtgat gactcaggct gcaccctcta tacctgtcac tcctggagag tcagtatcca      540

tctcctgcag gtctagtaag agtctcctga atagtaatgg caacacttac ttgtattggt      600

tcctgcagag gccaggccag tctcctcagc tcctgatata tcggatgtcc aaccttgcct      660

caggagtccc agacaggttc agtggcagtg ggtcaggaac tgctttcaca ctgagaatca      720

gtagagtgga ggctgaggat gtgggtgttt attactgtat gcaacatcta gaatatccgt      780

tcacgttcgg tgctgggacc aagctggagc tgaaacggac cacgacgcca gcgccgcgac      840

caccaacacc ggcgcccacc atcgcgtcgc agcccctgtc cctgcgccca gaggcgtgcc      900

ggccagcggc ggggggcgca gtgcacacga gggggctgga cttcgcctgt gatatctaca      960

tctgggcgcc cttggccggg acttgtgggg tccttctcct gtcactggtt atcacccttt     1020

actgcaaacg gggcagaaag aaactcctgt atatattcaa acaaccattt atgagaccag     1080

tacaaactac tcaagaggaa gatggctgta gctgccgatt tccagaagaa gaagaaggag     1140

gatgtgaact gagagtgaag ttcagcagga gcgcagacgc ccccgcgtac cagcagggcc     1200

agaaccagct ctataacgag ctcaatctag gacgaagaga ggagtacgat gttttggaca     1260

agagacgtgg ccgggaccct gagatggggg gaaagccgca gagaaggaag aaccctcagg     1320

aaggcctgta caatgaactg cagaaagata agatggcgga ggcctacagt gagattggga     1380

tgaaaggcga gcgccggagg ggcaaggggc acgatggcct ttaccagggt ctcagtacag     1440

ccaccaagga cacctacgac gcccttcaca tgcaggccct gccccctcgc ggaagcggag     1500

ccaccaactt cagcctgctg aagcaggccg gcgacgtgga ggagaacccc ggccccatgg     1560

ccctgcccgt gaccgccctg ctgctgcccc tggccctgct gctgcacgcc gccaggcccg     1620

acattcagct gacccagtct ccagcaatcc tttctgcatc tccaggggag aaggtcacaa     1680

tgacttgcag ggccagctca agtttaagtt tcatgcactg gtaccagcag aagccaggat     1740

cctcccccaa accctggatt tatgccacat ccaacctggc ttctggagtc cctgctcgct     1800

tcagtggcag tgggtctggg acctcttact ctctcacaat cagcacagtg gaggctgaag     1860

atgctgcctc ttatttctgc catcagtgga gtagtaaccc gctcacgttc ggtgctggga     1920

ccaagctgga gatcagctcg ggcggcggcg gctcgggcgg cggcggctcc ggagacgtca     1980

tgggggtgga ttctggggga ggcttagtgc agcctggagg gtcccggaaa ctctcctgtg     2040

cagcccctgg attcactttc agtagctttg ggatgcactg ggttcgtcag gctccagaga     2100

aggggttgga gtgggtcgca tacattagta gtcccagtag taccctccac tatgcagaca     2160

gagtgaaggg ccgattcacc atctccagag acaatcccaa gaacaccctg ttcctgcaaa     2220

tgaaactacc ctcactatgc tatggactac tggggccaag ggaccacgtt cacaccacca     2280

cccccgcccc caggcccccc acccccgccc ccaccatcgc cagccagccc ctgagcctga     2340

ggcccgaggc ctgcaggccc gccgccggcg gcgccgtgca caccaggggc ctggacttcg     2400

cctgcgacat ctacatctgg gcccccctgg ccggcacctg cggcgtgctg ctgctgagcc     2460

tggtgatcac cctgtactgc aggagtaaga ggagcaggct cctgcacagt gactacatga     2520

acatgactcc ccgccgcccc gggcccaccc gcaagcatta ccagccctat gccccaccac     2580

gcgacttcgc agcctatcgc tccagggtga agttcagcag gagcgccgac gcccccgcct     2640

accagcaggg ccagaaccag ctgtacaacg agctgaacct gggcaggagg gaggagtacg     2700

acgtgctgga caagaggagg ggcagggacc ccgagatggg cggcaagccc cagaggagga     2760

agaaccccca ggagggcctg tacaacgagc tgcagaagga caagatggcc gaggcctaca     2820

gcgagatcgg catgaagggc gagaggagga ggggcaaggg ccacgacggc ctgtaccagg     2880

gcctgagcac cgccaccaag gacacctacg acgccctgca catgcaggcc ctgcccccca     2940

ggtaagttta aac                                                        2953


<210>  66
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  66

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu 
            20                  25                  30          


Ile Lys Pro Gly Ala Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr 
        35                  40                  45              


Thr Phe Thr Ser Tyr Val Met His Trp Val Lys Gln Lys Pro Gly Gln 
    50                  55                  60                  


Gly Leu Glu Trp Ile Gly Tyr Ile Asn Pro Tyr Asn Asp Gly Thr Lys 
65                  70                  75                  80  


Tyr Asn Glu Lys Phe Lys Gly Lys Ala Thr Leu Thr Ser Asp Lys Ser 
                85                  90                  95      


Ser Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Thr Ser Glu Asp Ser 
            100                 105                 110         


Ala Val Tyr Tyr Cys Ala Arg Gly Thr Tyr Tyr Tyr Gly Ser Arg Val 
        115                 120                 125             


Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val 
145                 150                 155                 160 


Met Thr Gln Ala Ala Pro Ser Ile Pro Val Thr Pro Gly Glu Ser Val 
                165                 170                 175     


Ser Ile Ser Cys Arg Ser Ser Lys Ser Leu Leu Asn Ser Asn Gly Asn 
            180                 185                 190         


Thr Tyr Leu Tyr Trp Phe Leu Gln Arg Pro Gly Gln Ser Pro Gln Leu 
        195                 200                 205             


Leu Ile Tyr Arg Met Ser Asn Leu Ala Ser Gly Val Pro Asp Arg Phe 
    210                 215                 220                 


Ser Gly Ser Gly Ser Gly Thr Ala Phe Thr Leu Arg Ile Ser Arg Val 
225                 230                 235                 240 


Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln His Leu Glu Tyr 
                245                 250                 255     


Pro Phe Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Arg Thr Thr 
            260                 265                 270         


Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln 
        275                 280                 285             


Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala 
    290                 295                 300                 


Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala 
305                 310                 315                 320 


Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr 
                325                 330                 335     


Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln 
            340                 345                 350         


Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser 
        355                 360                 365             


Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys 
    370                 375                 380                 


Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln 
385                 390                 395                 400 


Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu 
                405                 410                 415     


Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Gln Arg 
            420                 425                 430         


Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys 
        435                 440                 445             


Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg 
    450                 455                 460                 


Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys 
465                 470                 475                 480 


Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg Gly Ser 
                485                 490                 495     


Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu 
            500                 505                 510         


Asn Pro Gly Pro Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu 
        515                 520                 525             


Ala Leu Leu Leu His Ala Ala Arg Pro Asp Ile Gln Leu Thr Gln Ser 
    530                 535                 540                 


Pro Ala Ile Leu Ser Ala Ser Pro Gly Glu Lys Val Thr Met Thr Cys 
545                 550                 555                 560 


Arg Ala Ser Ser Ser Leu Ser Phe Met His Trp Tyr Gln Gln Lys Pro 
                565                 570                 575     


Gly Ser Ser Pro Lys Pro Trp Ile Tyr Ala Thr Ser Asn Leu Ala Ser 
            580                 585                 590         


Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser 
        595                 600                 605             


Leu Thr Ile Ser Thr Val Glu Ala Glu Asp Ala Ala Ser Tyr Phe Cys 
    610                 615                 620                 


His Gln Trp Ser Ser Asn Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu 
625                 630                 635                 640 


Glu Ile Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Asp 
                645                 650                 655     


Val Met Gly Val Asp Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser 
            660                 665                 670         


Arg Lys Leu Ser Cys Ala Ala Pro Gly Phe Thr Phe Ser Ser Phe Gly 
        675                 680                 685             


Met His Trp Val Arg Gln Ala Pro Glu Lys Gly Leu Glu Trp Val Ala 
    690                 695                 700                 


Tyr Ile Ser Ser Pro Ser Ser Thr Leu His Tyr Ala Asp Arg Val Lys 
705                 710                 715                 720 


Gly Arg Phe Thr Ile Ser Arg Asp Asn Pro Lys Asn Thr Leu Phe Leu 
                725                 730                 735     


Gln Met Lys Leu Pro Ser Leu Cys Tyr Gly Leu Leu Gly Pro Arg Asp 
            740                 745                 750         


His Val His Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro 
        755                 760                 765             


Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro 
    770                 775                 780                 


Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp 
785                 790                 795                 800 


Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu 
                805                 810                 815     


Ser Leu Val Ile Thr Leu Tyr Cys Arg Ser Lys Arg Ser Arg Leu Leu 
            820                 825                 830         


His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg 
        835                 840                 845             


Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg 
    850                 855                 860                 


Ser Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln 
865                 870                 875                 880 


Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu 
                885                 890                 895     


Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly 
            900                 905                 910         


Lys Pro Gln Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu 
        915                 920                 925             


Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly 
    930                 935                 940                 


Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser 
945                 950                 955                 960 


Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro 
                965                 970                 975     


Pro Arg 
        


<210>  67
<211>  3010
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  67
gcgatcgcat ggccttacca gtgaccgcct tgctcctgcc gctggccttg ctgctccacg       60

ccgccaggcc ggaggtccag ctgcagcagt ctggacctga gctgataaag cctggggctt      120

cagtgaagat gtcctgcaag gcttctggat acacattcac tagctatgtt atgcactggg      180

tgaagcagaa gcctgggcag ggccttgagt ggattggata tattaatcct tacaatgatg      240

gtactaagta caatgagaag ttcaaaggca aggccacact gacttcagac aaatcctcca      300

gcacagccta catggagctc agcagcctga cctctgagga ctctgcggtc tattactgtg      360

caagagggac ttattactac ggtagtaggg tatttgacta ctggggccaa ggcaccactc      420

tcacagtctc ctcaggtgga gggggctcag gcggaggtgg ctctgggggt ggaggctcgg      480

acattgtgat gactcaggct gcaccctcta tacctgtcac tcctggagag tcagtatcca      540

tctcctgcag gtctagtaag agtctcctga atagtaatgg caacacttac ttgtattggt      600

tcctgcagag gccaggccag tctcctcagc tcctgatata tcggatgtcc aaccttgcct      660

caggagtccc agacaggttc agtggcagtg ggtcaggaac tgctttcaca ctgagaatca      720

gtagagtgga ggctgaggat gtgggtgttt attactgtat gcaacatcta gaatatccgt      780

tcacgttcgg tgctgggacc aagctggagc tgaaacggac cacgacgcca gcgccgcgac      840

caccaacacc ggcgcccacc atcgcgtcgc agcccctgtc cctgcgccca gaggcgtgcc      900

ggccagcggc ggggggcgca gtgcacacga gggggctgga cttcgcctgt gatatctaca      960

tctgggcgcc cttggccggg acttgtgggg tccttctcct gtcactggtt atcacccttt     1020

actgcaaacg gggcagaaag aaactcctgt atatattcaa acaaccattt atgagaccag     1080

tacaaactac tcaagaggaa gatggctgta gctgccgatt tccagaagaa gaagaaggag     1140

gatgtgaact gagagtgaag ttcagcagga gcgcagacgc ccccgcgtac cagcagggcc     1200

agaaccagct ctataacgag ctcaatctag gacgaagaga ggagtacgat gttttggaca     1260

agagacgtgg ccgggaccct gagatggggg gaaagccgca gagaaggaag aaccctcagg     1320

aaggcctgta caatgaactg cagaaagata agatggcgga ggcctacagt gagattggga     1380

tgaaaggcga gcgccggagg ggcaaggggc acgatggcct ttaccagggt ctcagtacag     1440

ccaccaagga cacctacgac gcccttcaca tgcaggccct gccccctcgc ggaagcggag     1500

ccaccaactt cagcctgctg aagcaggccg gcgacgtgga ggagaacccc ggccccatgg     1560

ccctgcccgt gaccgccctg ctgctgcccc tggccctgct gctgcacgcc gccaggcccg     1620

acgtgcagat cacccagagc cccagctacc tggccgccag ccccggcgag accatcacca     1680

tcaactgcag agccagcaag agcatcagca aggacctggc ctggtaccag gagaagcccg     1740

gcaagaccaa caagctgctg atctacagcg gcagcaccct gcagagcggc atccccagca     1800

gattcagcgg cagcggcagc ggcaccgact tcaccctgac catcagcagc ctggagcccg     1860

aggacttcgc catgtactac tgccagcagc acaacaagta cccctacacc ttcggcggcg     1920

gcaccaagct ggagatcaag ggaggggggg gatccggggg aggaggctcc ggcggaggcg     1980

gaagccaggt gcagctgcag cagcccggcg ccgagctggt gagacccggc gccagcgtga     2040

agctgagctg caaggccagc ggctacacct tcaccagcta ctggatgaac tgggtgaagc     2100

agagacccga ccagggcctg gagtggatcg gcagaatcga cccctacgac agcgagaccc     2160

actacaacca gaagttcaag gacaaggcca tcctgaccgt ggacaagagc agcagcaccg     2220

cctacatgca gctgagcagc ctgaccagcg aggacagcgc cgtgtactac tgcgccagag     2280

gcaactggga cgactactgg ggccagggca ccaccctgac cgtgagcagc accaccaccc     2340

ccgcccccag gccccccacc cccgccccca ccatcgccag ccagcccctg agcctgaggc     2400

ccgaggcctg caggcccgcc gccggcggcg ccgtgcacac caggggcctg gacttcgcct     2460

gcgacatcta catctgggcc cccctggccg gcacctgcgg cgtgctgctg ctgagcctgg     2520

tgatcaccct gtactgcagg agtaagagga gcaggctcct gcacagtgac tacatgaaca     2580

tgactccccg ccgccccggg cccacccgca agcattacca gccctatgcc ccaccacgcg     2640

acttcgcagc ctatcgctcc agggtgaagt tcagcaggag cgccgacgcc cccgcctacc     2700

agcagggcca gaaccagctg tacaacgagc tgaacctggg caggagggag gagtacgacg     2760

tgctggacaa gaggaggggc agggaccccg agatgggcgg caagccccag aggaggaaga     2820

acccccagga gggcctgtac aacgagctgc agaaggacaa gatggccgag gcctacagcg     2880

agatcggcat gaagggcgag aggaggaggg gcaagggcca cgacggcctg taccagggcc     2940

tgagcaccgc caccaaggac acctacgacg ccctgcacat gcaggccctg ccccccaggt     3000

aagtttaaac                                                            3010


<210>  68
<211>  997
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  68

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu 
            20                  25                  30          


Ile Lys Pro Gly Ala Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr 
        35                  40                  45              


Thr Phe Thr Ser Tyr Val Met His Trp Val Lys Gln Lys Pro Gly Gln 
    50                  55                  60                  


Gly Leu Glu Trp Ile Gly Tyr Ile Asn Pro Tyr Asn Asp Gly Thr Lys 
65                  70                  75                  80  


Tyr Asn Glu Lys Phe Lys Gly Lys Ala Thr Leu Thr Ser Asp Lys Ser 
                85                  90                  95      


Ser Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Thr Ser Glu Asp Ser 
            100                 105                 110         


Ala Val Tyr Tyr Cys Ala Arg Gly Thr Tyr Tyr Tyr Gly Ser Arg Val 
        115                 120                 125             


Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val 
145                 150                 155                 160 


Met Thr Gln Ala Ala Pro Ser Ile Pro Val Thr Pro Gly Glu Ser Val 
                165                 170                 175     


Ser Ile Ser Cys Arg Ser Ser Lys Ser Leu Leu Asn Ser Asn Gly Asn 
            180                 185                 190         


Thr Tyr Leu Tyr Trp Phe Leu Gln Arg Pro Gly Gln Ser Pro Gln Leu 
        195                 200                 205             


Leu Ile Tyr Arg Met Ser Asn Leu Ala Ser Gly Val Pro Asp Arg Phe 
    210                 215                 220                 


Ser Gly Ser Gly Ser Gly Thr Ala Phe Thr Leu Arg Ile Ser Arg Val 
225                 230                 235                 240 


Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln His Leu Glu Tyr 
                245                 250                 255     


Pro Phe Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Arg Thr Thr 
            260                 265                 270         


Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln 
        275                 280                 285             


Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala 
    290                 295                 300                 


Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala 
305                 310                 315                 320 


Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr 
                325                 330                 335     


Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln 
            340                 345                 350         


Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser 
        355                 360                 365             


Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys 
    370                 375                 380                 


Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln 
385                 390                 395                 400 


Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu 
                405                 410                 415     


Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Gln Arg 
            420                 425                 430         


Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys 
        435                 440                 445             


Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg 
    450                 455                 460                 


Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys 
465                 470                 475                 480 


Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg Gly Ser 
                485                 490                 495     


Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu 
            500                 505                 510         


Asn Pro Gly Pro Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu 
        515                 520                 525             


Ala Leu Leu Leu His Ala Ala Arg Pro Asp Val Gln Ile Thr Gln Ser 
    530                 535                 540                 


Pro Ser Tyr Leu Ala Ala Ser Pro Gly Glu Thr Ile Thr Ile Asn Cys 
545                 550                 555                 560 


Arg Ala Ser Lys Ser Ile Ser Lys Asp Leu Ala Trp Tyr Gln Glu Lys 
                565                 570                 575     


Pro Gly Lys Thr Asn Lys Leu Leu Ile Tyr Ser Gly Ser Thr Leu Gln 
            580                 585                 590         


Ser Gly Ile Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 
        595                 600                 605             


Thr Leu Thr Ile Ser Ser Leu Glu Pro Glu Asp Phe Ala Met Tyr Tyr 
    610                 615                 620                 


Cys Gln Gln His Asn Lys Tyr Pro Tyr Thr Phe Gly Gly Gly Thr Lys 
625                 630                 635                 640 


Leu Glu Ile Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
                645                 650                 655     


Gly Gly Ser Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Arg 
            660                 665                 670         


Pro Gly Ala Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
        675                 680                 685             


Thr Ser Tyr Trp Met Asn Trp Val Lys Gln Arg Pro Asp Gln Gly Leu 
    690                 695                 700                 


Glu Trp Ile Gly Arg Ile Asp Pro Tyr Asp Ser Glu Thr His Tyr Asn 
705                 710                 715                 720 


Gln Lys Phe Lys Asp Lys Ala Ile Leu Thr Val Asp Lys Ser Ser Ser 
                725                 730                 735     


Thr Ala Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val 
            740                 745                 750         


Tyr Tyr Cys Ala Arg Gly Asn Trp Asp Asp Tyr Trp Gly Gln Gly Thr 
        755                 760                 765             


Thr Leu Thr Val Ser Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr 
    770                 775                 780                 


Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala 
785                 790                 795                 800 


Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe 
                805                 810                 815     


Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val 
            820                 825                 830         


Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Arg Ser Lys Arg Ser 
        835                 840                 845             


Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly 
    850                 855                 860                 


Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala 
865                 870                 875                 880 


Ala Tyr Arg Ser Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala 
                885                 890                 895     


Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg 
            900                 905                 910         


Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu 
        915                 920                 925             


Met Gly Gly Lys Pro Gln Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr 
    930                 935                 940                 


Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly 
945                 950                 955                 960 


Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln 
                965                 970                 975     


Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln 
            980                 985                 990         


Ala Leu Pro Pro Arg 
        995         


<210>  69
<211>  1767
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  69
gcgatcgctg acctctagaa tgtatttgtg gcttaaactc ttggcatttg gctttgcctt       60

tctggacaca gaagtatttg tgacagggga catccaggtg acccagagcc ccagcagcct      120

gagcgccagc ctgggcgaga gaatcagcct gacctgcaga accagccagg acatcagcaa      180

ctacctgaac tggttccagc agaagcccga cggcaccttc aagagactga tctacgccac      240

cagcagcctg gacagcggcg tgcccaagag attcagcggc agcggcagcg gcagcgacta      300

cagcctgacc atcagcagcc tggagagcga ggacttcgcc gactactact gcctgcagta      360

cgccagctac cccttcacct tcggcagcgg caccaagctg gagatcaagg gagggggggg      420

atccggggga ggaggctccg gcggaggcgg aagcgaggtg cagctgcagg agagcggccc      480

cggcctggtg aagcccagcc agaccctgag cctgacctgc agcgtgaccg gctacagcat      540

caccagcggc tactactggc actggatcag acagttcccc ggcaacaagc tgcagtggat      600

gggctacatc agctacagcg gcttcaccaa ctacaagacc agcctgatca acagaatcag      660

catcacccac gacaccagcg agaaccagtt cttcctgaac ctgaacagcg tgaccaccga      720

ggacaccgcc acctactact gcgccggcga cagaaccggc agctggttcg cctactgggg      780

ccagggcacc ctggtgaccg tgagcgccac cacgacgcca gcgccgcgac caccaacacc      840

ggcgcccacc atcgcgtcgc agcccctgtc cctgcgccca gaggcgtgcc ggccagcggc      900

ggggggcgca gtgcacacga gggggctgga cttcgcctgt gatatctaca tctgggcgcc      960

cttggccggg acttgtgggg tccttctcct gtcactggtt atcacccttt actgcaggag     1020

taagaggagc aggctcctgc acagtgacta catgaacatg actccccgcc gccccgggcc     1080

cacccgcaag cattaccagc cctatgcccc accacgcgac ttcgcagcct atcgctccag     1140

agtgaagttc agcaggagcg cagacgcccc cgcgtaccag cagggccaga accagctcta     1200

taacgagctc aatctaggac gaagagagga gtacgatgtt ttggacaaga gacgtggccg     1260

ggaccctgag atggggggaa agccgcagag aaggaagaac cctcaggaag gcctgtacaa     1320

tgaactgcag aaagataaga tggcggaggc ctacagtgag attgggatga aaggcgagcg     1380

ccggaggggc aaggggcacg atggccttta ccagggtctc agtacagcca ccaaggacac     1440

ctacgacgcc cttcacatgc aggccctgcc ccctcgcggc agcggcgaag gccgcggcag     1500

cctgctgacc tgcggcgatg tggaagaaaa cccgggcccc atgtacctgt ggctgaagct     1560

gctggccttc ggcttcgcct tcctggacac cgaggtgttc gtgaccggcg gccagaacga     1620

caccagccag accagcagcc ccagcagccc gctgtttccg ggcccgagca aaccgttttg     1680

ggtgctggtg gtggtgggcg gcgtgctggc gtgctatagc ctgctggtga ccgtggcgtt     1740

tattattttt tgggtgtaag tttaaac                                         1767


<210>  70
<211>  579
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  70

Met Tyr Leu Trp Leu Lys Leu Leu Ala Phe Gly Phe Ala Phe Leu Asp 
1               5                   10                  15      


Thr Glu Val Phe Val Thr Gly Asp Ile Gln Val Thr Gln Ser Pro Ser 
            20                  25                  30          


Ser Leu Ser Ala Ser Leu Gly Glu Arg Ile Ser Leu Thr Cys Arg Thr 
        35                  40                  45              


Ser Gln Asp Ile Ser Asn Tyr Leu Asn Trp Phe Gln Gln Lys Pro Asp 
    50                  55                  60                  


Gly Thr Phe Lys Arg Leu Ile Tyr Ala Thr Ser Ser Leu Asp Ser Gly 
65                  70                  75                  80  


Val Pro Lys Arg Phe Ser Gly Ser Gly Ser Gly Ser Asp Tyr Ser Leu 
                85                  90                  95      


Thr Ile Ser Ser Leu Glu Ser Glu Asp Phe Ala Asp Tyr Tyr Cys Leu 
            100                 105                 110         


Gln Tyr Ala Ser Tyr Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu 
        115                 120                 125             


Ile Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Glu Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser 
145                 150                 155                 160 


Gln Thr Leu Ser Leu Thr Cys Ser Val Thr Gly Tyr Ser Ile Thr Ser 
                165                 170                 175     


Gly Tyr Tyr Trp His Trp Ile Arg Gln Phe Pro Gly Asn Lys Leu Gln 
            180                 185                 190         


Trp Met Gly Tyr Ile Ser Tyr Ser Gly Phe Thr Asn Tyr Lys Thr Ser 
        195                 200                 205             


Leu Ile Asn Arg Ile Ser Ile Thr His Asp Thr Ser Glu Asn Gln Phe 
    210                 215                 220                 


Phe Leu Asn Leu Asn Ser Val Thr Thr Glu Asp Thr Ala Thr Tyr Tyr 
225                 230                 235                 240 


Cys Ala Gly Asp Arg Thr Gly Ser Trp Phe Ala Tyr Trp Gly Gln Gly 
                245                 250                 255     


Thr Leu Val Thr Val Ser Ala Thr Thr Thr Pro Ala Pro Arg Pro Pro 
            260                 265                 270         


Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu 
        275                 280                 285             


Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp 
    290                 295                 300                 


Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly 
305                 310                 315                 320 


Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Arg Ser Lys Arg 
                325                 330                 335     


Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro 
            340                 345                 350         


Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe 
        355                 360                 365             


Ala Ala Tyr Arg Ser Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro 
    370                 375                 380                 


Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly 
385                 390                 395                 400 


Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro 
                405                 410                 415     


Glu Met Gly Gly Lys Pro Gln Arg Arg Lys Asn Pro Gln Glu Gly Leu 
            420                 425                 430         


Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile 
        435                 440                 445             


Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr 
    450                 455                 460                 


Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met 
465                 470                 475                 480 


Gln Ala Leu Pro Pro Arg Gly Ser Gly Glu Gly Arg Gly Ser Leu Leu 
                485                 490                 495     


Thr Cys Gly Asp Val Glu Glu Asn Pro Gly Pro Met Tyr Leu Trp Leu 
            500                 505                 510         


Lys Leu Leu Ala Phe Gly Phe Ala Phe Leu Asp Thr Glu Val Phe Val 
        515                 520                 525             


Thr Gly Gly Gln Asn Asp Thr Ser Gln Thr Ser Ser Pro Ser Ser Pro 
    530                 535                 540                 


Leu Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val Val Gly 
545                 550                 555                 560 


Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile 
                565                 570                 575     


Phe Trp Val 
            


<210>  71
<211>  1880
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  71
atgtacctgt ggctgaagct gctggccttc ggcttcgcct tcctggacac cgaggtgttc       60

gtgaccggcg acatccaggt gacccagagc cccagcagcc tgagcgccag cctgggcgag      120

agaatcagcc tgacctgcag aaccagccag gacatcagca actacctgaa ctggttccag      180

cagaagcccg acggcacctt caagagactg atctacgcca ccagcagcct ggacagcggc      240

gtgcccaaga gattcagcgg cagcggcagc ggcagcgact acagcctgac catcagcagc      300

ctggagagcg aggacttcgc cgactactac tgcctgcagt acgccagcta ccccttcacc      360

ttcggcagcg gcaccaagct ggagatcaag ggaggggggg gatccggggg aggaggctcc      420

ggcggaggcg gaagcgaggt gcagctgcag gagagcggcc ccggcctggt gaagcccagc      480

cagaccctga gcctgacctg cagcgtgacc ggctacagca tcaccagcgg ctactactgg      540

cactggatca gacagttccc cggcaacaag ctgcagtgga tgggctacat cagctacagc      600

ggcttcacca actacaagac cagcctgatc aacagaatca gcatcaccca cgacaccagc      660

gagaaccagt tcttcctgaa cctgaacagc gtgaccaccg aggacaccgc cacctactac      720

tgcgccggcg acagaaccgg cagctggttc gcctactggg gccagggcac cctggtgacc      780

gtgagcgcca ccacgacgcc agcgccgcga ccaccaacac cggcgcccac catcgcgtcg      840

cagcccctgt ccctgcgccc agaggcgtgc cggccagcgg cggggggcgc agtgcacacg      900

agggggctgg acttcgcctg tgatatctac atctgggcgc ccttggccgg gacttgtggg      960

gtccttctcc tgtcactggt tatcaccctt tactgcagga gtaagaggag caggctcctg     1020

cacagtgact acatgaacat gactccccgc cgccccgggc ccacccgcaa gcattaccag     1080

ccctatgccc caccacgcga cttcgcagcc tatcgctcca aacggggcag aaagaaactc     1140

ctgtatatat tcaaacaacc atttatgaga ccagtacaaa ctactcaaga ggaagatggc     1200

tgtagctgcc gatttccaga agaagaagaa ggaggatgtg aactgagagt gaagttcagc     1260

aggagcgcag acgcccccgc gtaccagcag ggccagaacc agctctataa cgagctcaat     1320

ctaggacgaa gagaggagta cgatgttttg gacaagagac gtggccggga ccctgagatg     1380

gggggaaagc cgcagagaag gaagaaccct caggaaggcc tgtacaatga actgcagaaa     1440

gataagatgg cggaggccta cagtgagatt gggatgaaag gcgagcgccg gaggggcaag     1500

gggcacgatg gcctttacca gggtctcagt acagccacca aggacaccta cgacgccctt     1560

cacatgcagg ccctgccccc tcgcatcgat ggcagcggcg agggcagggg cagcctgctg     1620

acctgcggcg acgtggagga gaaccccggc cccatggcct taccagtgac cgccttgctc     1680

ctgccgctgg ccttgctgct ccacgccgcc aggccgggcc agaacgacac cagccagacc     1740

agcagcccca gcagccccct gttccccggc cccagcaagc ccttctgggt gctggtggtg     1800

gtgggcggcg tgctggcctg ctacagcctg ctggtgaccg tggccttcat catcttctgg     1860

gtgaggagct aagtttaaac                                                 1880


<210>  72
<211>  623
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  72

Met Tyr Leu Trp Leu Lys Leu Leu Ala Phe Gly Phe Ala Phe Leu Asp 
1               5                   10                  15      


Thr Glu Val Phe Val Thr Gly Asp Ile Gln Val Thr Gln Ser Pro Ser 
            20                  25                  30          


Ser Leu Ser Ala Ser Leu Gly Glu Arg Ile Ser Leu Thr Cys Arg Thr 
        35                  40                  45              


Ser Gln Asp Ile Ser Asn Tyr Leu Asn Trp Phe Gln Gln Lys Pro Asp 
    50                  55                  60                  


Gly Thr Phe Lys Arg Leu Ile Tyr Ala Thr Ser Ser Leu Asp Ser Gly 
65                  70                  75                  80  


Val Pro Lys Arg Phe Ser Gly Ser Gly Ser Gly Ser Asp Tyr Ser Leu 
                85                  90                  95      


Thr Ile Ser Ser Leu Glu Ser Glu Asp Phe Ala Asp Tyr Tyr Cys Leu 
            100                 105                 110         


Gln Tyr Ala Ser Tyr Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu 
        115                 120                 125             


Ile Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Glu Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser 
145                 150                 155                 160 


Gln Thr Leu Ser Leu Thr Cys Ser Val Thr Gly Tyr Ser Ile Thr Ser 
                165                 170                 175     


Gly Tyr Tyr Trp His Trp Ile Arg Gln Phe Pro Gly Asn Lys Leu Gln 
            180                 185                 190         


Trp Met Gly Tyr Ile Ser Tyr Ser Gly Phe Thr Asn Tyr Lys Thr Ser 
        195                 200                 205             


Leu Ile Asn Arg Ile Ser Ile Thr His Asp Thr Ser Glu Asn Gln Phe 
    210                 215                 220                 


Phe Leu Asn Leu Asn Ser Val Thr Thr Glu Asp Thr Ala Thr Tyr Tyr 
225                 230                 235                 240 


Cys Ala Gly Asp Arg Thr Gly Ser Trp Phe Ala Tyr Trp Gly Gln Gly 
                245                 250                 255     


Thr Leu Val Thr Val Ser Ala Thr Thr Thr Pro Ala Pro Arg Pro Pro 
            260                 265                 270         


Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu 
        275                 280                 285             


Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp 
    290                 295                 300                 


Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly 
305                 310                 315                 320 


Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Arg Ser Lys Arg 
                325                 330                 335     


Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro 
            340                 345                 350         


Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe 
        355                 360                 365             


Ala Ala Tyr Arg Ser Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe 
    370                 375                 380                 


Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly 
385                 390                 395                 400 


Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg 
                405                 410                 415     


Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln 
            420                 425                 430         


Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp 
        435                 440                 445             


Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro 
    450                 455                 460                 


Gln Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys 
465                 470                 475                 480 


Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg 
                485                 490                 495     


Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala 
            500                 505                 510         


Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
        515                 520                 525             


Ile Asp Gly Ser Gly Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp 
    530                 535                 540                 


Val Glu Glu Asn Pro Gly Pro Met Ala Leu Pro Val Thr Ala Leu Leu 
545                 550                 555                 560 


Leu Pro Leu Ala Leu Leu Leu His Ala Ala Arg Pro Gly Gln Asn Asp 
                565                 570                 575     


Thr Ser Gln Thr Ser Ser Pro Ser Ser Pro Leu Phe Pro Gly Pro Ser 
            580                 585                 590         


Lys Pro Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr 
        595                 600                 605             


Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser 
    610                 615                 620             


<210>  73
<211>  2314
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  73
gcgatcgcat ggccttacca gtgaccgcct tgctcctgcc gctggccttg ctgctccacg       60

ccgccaggcc ggacatcgtg ctgacccaga gccccgccag cctggccgtg agcctgggcc      120

agagggccac catcagctgc agggccagca agagcgtgag caccagcggc tacagctacc      180

tgcactggta ccagcagaag cccggccagc cccccaagct gctgatctac ctggccagca      240

acctggagag cggcgtgccc gccaggttca gcggcagcgg cagcggcacc gacttcaccc      300

tgaacatcca ccccgtggag gaggaggacg ccgccaccta ctactgccag cacagcaggg      360

agctgccctt caccttcggc agcggcacca agctggagat caagggaggg gggggatccg      420

ggggaggagg ctccggcgga ggcggaagcc aggtgcagct ggtggagagc ggcggcggcc      480

tggtgcagcc cggcggcagc ctgaagctga gctgcgccgc cagcggcttc gacttcagca      540

ggtactggat gagctgggtg aggcaggccc ccggcaaggg cctggagtgg atcggcgaga      600

tcaaccccac cagcagcacc atcaacttca cccccagcct gaaggacaag gtgttcatca      660

gcagggacaa cgccaagaac accctgtacc tgcagatgag caaggtgagg agcgaggaca      720

ccgccctgta ctactgcgcc aggggcaact actacaggta cggcgacgcc atggactact      780

ggggccaggg caccagcgtg accgtgagca ccacgacgcc agcgccgcga ccaccaacac      840

cggcgcccac catcgcgtcg cagcccctgt ccctgcgccc agaggcgtgc cggccagcgg      900

cggggggcgc agtgcacacg agggggctgg acttcgcctg tgatatctac atctgggcgc      960

ccttggccgg gacttgtggg gtccttctcc tgtcactggt tatcaccctt tactgcagga     1020

gtaagaggag caggctcctg cacagtgact acatgaacat gactccccgc cgccccgggc     1080

ccacccgcaa gcattaccag ccctatgccc caccacgcga cttcgcagcc tatcgctcca     1140

gagtgaagtt cagcaggagc gcagacgccc ccgcgtacca gcagggccag aaccagctct     1200

ataacgagct caatctagga cgaagagagg agtacgatgt tttggacaag agacgtggcc     1260

gggaccctga gatgggggga aagccgcaga gaaggaagaa ccctcaggaa ggcctgtaca     1320

atgaactgca gaaagataag atggcggagg cctacagtga gattgggatg aaaggcgagc     1380

gccggagggg caaggggcac gatggccttt accagggtct cagtacagcc accaaggaca     1440

cctacgacgc ccttcacatg caggccctgc cccctcgcgg cagcggcgaa ggccgcggca     1500

gcctgctgac ctgcggcgat gtggaagaaa acccgggccc catggaatac gcctctgacg     1560

cttcactgga ccccgaagcc ccgtggcctc ccgcgccccg cgctcgcgcc tgccgcgtac     1620

tgccttgggc cctggtcgcg gggctgctgc tgctgctgct gctcgctgcc gcctgcgccg     1680

tcttcctcgc ctgcccctgg gccgtgtccg gggctcgcgc ctcgcccggc tccgcggcca     1740

gcccgagact ccgcgagggt cccgagcttt cgcccgacga tcccgccggc ctcttggacc     1800

tgcggcaggg catgtttgcg cagctggtgg cccaaaatgt tctgctgatc gatgggcccc     1860

tgagctggta cagtgaccca ggcctggcag gcgtgtccct gacggggggc ctgagctaca     1920

aagaggacac gaaggagctg gtggtggcca aggctggagt ctactatgtc ttctttcaac     1980

tagagctgcg gcgcgtggtg gccggcgagg gctcaggctc cgtttcactt gcgctgcacc     2040

tgcagccact gcgctctgct gctggggccg ccgccctggc tttgaccgtg gacctgccac     2100

ccgcctcctc cgaggctcgg aactcggcct tcggtttcca gggccgcttg ctgcacctga     2160

gtgccggcca gcgcctgggc gtccatcttc acactgaggc cagggcacgc catgcctggc     2220

agcttaccca gggcgccaca gtcttgggac tcttccgggt gacccccgaa atcccagccg     2280

gactcccttc accgaggtcg gaataagttt aaac                                 2314


<210>  74
<211>  765
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  74

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu 
            20                  25                  30          


Ala Val Ser Leu Gly Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Lys 
        35                  40                  45              


Ser Val Ser Thr Ser Gly Tyr Ser Tyr Leu His Trp Tyr Gln Gln Lys 
    50                  55                  60                  


Pro Gly Gln Pro Pro Lys Leu Leu Ile Tyr Leu Ala Ser Asn Leu Glu 
65                  70                  75                  80  


Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 
                85                  90                  95      


Thr Leu Asn Ile His Pro Val Glu Glu Glu Asp Ala Ala Thr Tyr Tyr 
            100                 105                 110         


Cys Gln His Ser Arg Glu Leu Pro Phe Thr Phe Gly Ser Gly Thr Lys 
        115                 120                 125             


Leu Glu Ile Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln 
145                 150                 155                 160 


Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Asp Phe 
                165                 170                 175     


Ser Arg Tyr Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
            180                 185                 190         


Glu Trp Ile Gly Glu Ile Asn Pro Thr Ser Ser Thr Ile Asn Phe Thr 
        195                 200                 205             


Pro Ser Leu Lys Asp Lys Val Phe Ile Ser Arg Asp Asn Ala Lys Asn 
    210                 215                 220                 


Thr Leu Tyr Leu Gln Met Ser Lys Val Arg Ser Glu Asp Thr Ala Leu 
225                 230                 235                 240 


Tyr Tyr Cys Ala Arg Gly Asn Tyr Tyr Arg Tyr Gly Asp Ala Met Asp 
                245                 250                 255     


Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Thr Thr Thr Pro Ala 
            260                 265                 270         


Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser 
        275                 280                 285             


Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr 
    290                 295                 300                 


Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala 
305                 310                 315                 320 


Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys 
                325                 330                 335     


Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr 
            340                 345                 350         


Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro 
        355                 360                 365             


Pro Arg Asp Phe Ala Ala Tyr Arg Ser Arg Val Lys Phe Ser Arg Ser 
    370                 375                 380                 


Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu 
385                 390                 395                 400 


Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg 
                405                 410                 415     


Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Gln Arg Arg Lys Asn Pro 
            420                 425                 430         


Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala 
        435                 440                 445             


Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His 
    450                 455                 460                 


Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp 
465                 470                 475                 480 


Ala Leu His Met Gln Ala Leu Pro Pro Arg Gly Ser Gly Glu Gly Arg 
                485                 490                 495     


Gly Ser Leu Leu Thr Cys Gly Asp Val Glu Glu Asn Pro Gly Pro Met 
            500                 505                 510         


Glu Tyr Ala Ser Asp Ala Ser Leu Asp Pro Glu Ala Pro Trp Pro Pro 
        515                 520                 525             


Ala Pro Arg Ala Arg Ala Cys Arg Val Leu Pro Trp Ala Leu Val Ala 
    530                 535                 540                 


Gly Leu Leu Leu Leu Leu Leu Leu Ala Ala Ala Cys Ala Val Phe Leu 
545                 550                 555                 560 


Ala Cys Pro Trp Ala Val Ser Gly Ala Arg Ala Ser Pro Gly Ser Ala 
                565                 570                 575     


Ala Ser Pro Arg Leu Arg Glu Gly Pro Glu Leu Ser Pro Asp Asp Pro 
            580                 585                 590         


Ala Gly Leu Leu Asp Leu Arg Gln Gly Met Phe Ala Gln Leu Val Ala 
        595                 600                 605             


Gln Asn Val Leu Leu Ile Asp Gly Pro Leu Ser Trp Tyr Ser Asp Pro 
    610                 615                 620                 


Gly Leu Ala Gly Val Ser Leu Thr Gly Gly Leu Ser Tyr Lys Glu Asp 
625                 630                 635                 640 


Thr Lys Glu Leu Val Val Ala Lys Ala Gly Val Tyr Tyr Val Phe Phe 
                645                 650                 655     


Gln Leu Glu Leu Arg Arg Val Val Ala Gly Glu Gly Ser Gly Ser Val 
            660                 665                 670         


Ser Leu Ala Leu His Leu Gln Pro Leu Arg Ser Ala Ala Gly Ala Ala 
        675                 680                 685             


Ala Leu Ala Leu Thr Val Asp Leu Pro Pro Ala Ser Ser Glu Ala Arg 
    690                 695                 700                 


Asn Ser Ala Phe Gly Phe Gln Gly Arg Leu Leu His Leu Ser Ala Gly 
705                 710                 715                 720 


Gln Arg Leu Gly Val His Leu His Thr Glu Ala Arg Ala Arg His Ala 
                725                 730                 735     


Trp Gln Leu Thr Gln Gly Ala Thr Val Leu Gly Leu Phe Arg Val Thr 
            740                 745                 750         


Pro Glu Ile Pro Ala Gly Leu Pro Ser Pro Arg Ser Glu 
        755                 760                 765 


<210>  75
<211>  2371
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  75
gcgatcgcat ggccttacca gtgaccgcct tgctcctgcc gctggccttg ctgctccacg       60

ccgccaggcc ggacatcgtg ctgacccaga gccccgccag cctggccgtg agcctgggcc      120

agagggccac catcagctgc agggccagca agagcgtgag caccagcggc tacagctacc      180

tgcactggta ccagcagaag cccggccagc cccccaagct gctgatctac ctggccagca      240

acctggagag cggcgtgccc gccaggttca gcggcagcgg cagcggcacc gacttcaccc      300

tgaacatcca ccccgtggag gaggaggacg ccgccaccta ctactgccag cacagcaggg      360

agctgccctt caccttcggc agcggcacca agctggagat caagggaggg gggggatccg      420

ggggaggagg ctccggcgga ggcggaagcc aggtgcagct ggtggagagc ggcggcggcc      480

tggtgcagcc cggcggcagc ctgaagctga gctgcgccgc cagcggcttc gacttcagca      540

ggtactggat gagctgggtg aggcaggccc ccggcaaggg cctggagtgg atcggcgaga      600

tcaaccccac cagcagcacc atcaacttca cccccagcct gaaggacaag gtgttcatca      660

gcagggacaa cgccaagaac accctgtacc tgcagatgag caaggtgagg agcgaggaca      720

ccgccctgta ctactgcgcc aggggcaact actacaggta cggcgacgcc atggactact      780

ggggccaggg caccagcgtg accgtgagca ccacgacgcc agcgccgcga ccaccaacac      840

cggcgcccac catcgcgtcg cagcccctgt ccctgcgccc agaggcgtgc cggccagcgg      900

cggggggcgc agtgcacacg agggggctgg acttcgcctg tgatatctac atctgggcgc      960

ccttggccgg gacttgtggg gtccttctcc tgtcactggt tatcaccctt tactgcagga     1020

gtaagaggag caggctcctg cacagtgact acatgaacat gactccccgc cgccccgggc     1080

ccacccgcaa gcattaccag ccctatgccc caccacgcga cttcgcagcc tatcgctcca     1140

gagtgaagtt cagcaggagc gcagacgccc ccgcgtacca gcagggccag aaccagctct     1200

ataacgagct caatctagga cgaagagagg agtacgatgt tttggacaag agacgtggcc     1260

gggaccctga gatgggggga aagccgcaga gaaggaagaa ccctcaggaa ggcctgtaca     1320

atgaactgca gaaagataag atggcggagg cctacagtga gattgggatg aaaggcgagc     1380

gccggagggg caaggggcac gatggccttt accagggtct cagtacagcc accaaggaca     1440

cctacgacgc ccttcacatg caggccctgc cccctcgcgg cagcggcgaa ggccgcggca     1500

gcctgctgac ctgcggcgat gtggaagaaa acccgggccc catgtacaga atgcagctgc     1560

tgagctgcat cgccctgagc ctggccctgg tgaccaacag cggcatccac gtgttcatcc     1620

tgggctgctt cagcgccggc ctgcccaaga ccgaggccaa ctgggtgaac gtgatcagcg     1680

acctgaagaa gatcgaggac ctgatccaga gcatgcacat cgacgccacc ctgtacaccg     1740

agagcgacgt gcaccccagc tgcaaggtga ccgccatgaa gtgcttcctg ctggagctgc     1800

aggtgatcag cctggagagc ggcgacgcca gcatccacga caccgtggag aacctgatca     1860

tcctggccaa caacagcctg agcagcaacg gcaacgtgac cgagagcggc tgcaaggagt     1920

gcgaggagct ggaggagaag aacatcaagg agttcctgca gagcttcgtg cacatcgtgc     1980

agatgttcat caacaccagc tccggcggcg gctccggcgg cggcggctcc ggcggcggcg     2040

gctccggcgg cggcggctcc ggcggcggct ccctgcaggc ccccagaaga gccagaggct     2100

gcagaaccct gggcctgccc gccctgctgc tgctgctgct gctgagaccc cccgccacca     2160

gaggcatcac ctgccccccc cccatgagcg tggagcacgc cgacatctgg gtgaagagct     2220

acagcctgta cagcagagag agatacatct gcaacagcgg cttcaagaga aaggccggca     2280

ccagcagcct gaccgagtgc gtgctgaaca aggccaccaa cgtggcccac tggaccaccc     2340

ccagcctgaa gtgcatcaga taagtttaaa c                                    2371


<210>  76
<211>  784
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  76

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu 
            20                  25                  30          


Ala Val Ser Leu Gly Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Lys 
        35                  40                  45              


Ser Val Ser Thr Ser Gly Tyr Ser Tyr Leu His Trp Tyr Gln Gln Lys 
    50                  55                  60                  


Pro Gly Gln Pro Pro Lys Leu Leu Ile Tyr Leu Ala Ser Asn Leu Glu 
65                  70                  75                  80  


Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 
                85                  90                  95      


Thr Leu Asn Ile His Pro Val Glu Glu Glu Asp Ala Ala Thr Tyr Tyr 
            100                 105                 110         


Cys Gln His Ser Arg Glu Leu Pro Phe Thr Phe Gly Ser Gly Thr Lys 
        115                 120                 125             


Leu Glu Ile Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln 
145                 150                 155                 160 


Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Asp Phe 
                165                 170                 175     


Ser Arg Tyr Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
            180                 185                 190         


Glu Trp Ile Gly Glu Ile Asn Pro Thr Ser Ser Thr Ile Asn Phe Thr 
        195                 200                 205             


Pro Ser Leu Lys Asp Lys Val Phe Ile Ser Arg Asp Asn Ala Lys Asn 
    210                 215                 220                 


Thr Leu Tyr Leu Gln Met Ser Lys Val Arg Ser Glu Asp Thr Ala Leu 
225                 230                 235                 240 


Tyr Tyr Cys Ala Arg Gly Asn Tyr Tyr Arg Tyr Gly Asp Ala Met Asp 
                245                 250                 255     


Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Thr Thr Thr Pro Ala 
            260                 265                 270         


Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser 
        275                 280                 285             


Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr 
    290                 295                 300                 


Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala 
305                 310                 315                 320 


Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys 
                325                 330                 335     


Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr 
            340                 345                 350         


Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro 
        355                 360                 365             


Pro Arg Asp Phe Ala Ala Tyr Arg Ser Arg Val Lys Phe Ser Arg Ser 
    370                 375                 380                 


Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu 
385                 390                 395                 400 


Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg 
                405                 410                 415     


Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Gln Arg Arg Lys Asn Pro 
            420                 425                 430         


Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala 
        435                 440                 445             


Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His 
    450                 455                 460                 


Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp 
465                 470                 475                 480 


Ala Leu His Met Gln Ala Leu Pro Pro Arg Gly Ser Gly Glu Gly Arg 
                485                 490                 495     


Gly Ser Leu Leu Thr Cys Gly Asp Val Glu Glu Asn Pro Gly Pro Met 
            500                 505                 510         


Tyr Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu Val 
        515                 520                 525             


Thr Asn Ser Gly Ile His Val Phe Ile Leu Gly Cys Phe Ser Ala Gly 
    530                 535                 540                 


Leu Pro Lys Thr Glu Ala Asn Trp Val Asn Val Ile Ser Asp Leu Lys 
545                 550                 555                 560 


Lys Ile Glu Asp Leu Ile Gln Ser Met His Ile Asp Ala Thr Leu Tyr 
                565                 570                 575     


Thr Glu Ser Asp Val His Pro Ser Cys Lys Val Thr Ala Met Lys Cys 
            580                 585                 590         


Phe Leu Leu Glu Leu Gln Val Ile Ser Leu Glu Ser Gly Asp Ala Ser 
        595                 600                 605             


Ile His Asp Thr Val Glu Asn Leu Ile Ile Leu Ala Asn Asn Ser Leu 
    610                 615                 620                 


Ser Ser Asn Gly Asn Val Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu 
625                 630                 635                 640 


Leu Glu Glu Lys Asn Ile Lys Glu Phe Leu Gln Ser Phe Val His Ile 
                645                 650                 655     


Val Gln Met Phe Ile Asn Thr Ser Ser Gly Gly Gly Ser Gly Gly Gly 
            660                 665                 670         


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser 
        675                 680                 685             


Leu Gln Ala Pro Arg Arg Ala Arg Gly Cys Arg Thr Leu Gly Leu Pro 
    690                 695                 700                 


Ala Leu Leu Leu Leu Leu Leu Leu Arg Pro Pro Ala Thr Arg Gly Ile 
705                 710                 715                 720 


Thr Cys Pro Pro Pro Met Ser Val Glu His Ala Asp Ile Trp Val Lys 
                725                 730                 735     


Ser Tyr Ser Leu Tyr Ser Arg Glu Arg Tyr Ile Cys Asn Ser Gly Phe 
            740                 745                 750         


Lys Arg Lys Ala Gly Thr Ser Ser Leu Thr Glu Cys Val Leu Asn Lys 
        755                 760                 765             


Ala Thr Asn Val Ala His Trp Thr Thr Pro Ser Leu Lys Cys Ile Arg 
    770                 775                 780                 


<210>  77
<211>  1223
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  77
gcgatcgctg ccatcgatac catgtatttg tggcttaaac tcttggcatt tggctttgcc       60

tttctggaca cagaagtatt tgtgacaggg gccgttcagg gtccagaaga aacagtcact      120

caagactgct tgcaactgat tgcagacagt gaaacaccaa ctatacaaaa aggatcttac      180

acatttgttc catggcttct cagctttaaa aggggaagtg ccctagaaga aaaagagaat      240

aaaatattgg tcaaagaaac tggttacttt tttatatatg gtcaggtttt atatactgat      300

aagacctacg ccatgggaca tctaattcag aggaagaagg tccatgtctt tggggatgaa      360

ttgagtctgg tgactttgtt tcgatgtatt caaaatatgc ctgaaacact acccaataat      420

tcctgctatt cagctggcat tgcaaaactg gaagaaggag atgaactcca acttgcaata      480

ccaagagaaa atgcacaaat atcactggat ggagatgtca cattttttgg tgcattgaaa      540

ctgctgacca cgacgccagc gccgcgacca ccaacaccgg cgcccaccat cgcgtcgcag      600

cccctgtccc tgcgcccaga ggcgtgccgg ccagcggcgg ggggcgcagt gcacacgagg      660

gggctggact tcgcctgtga tatctacatc tgggcgccct tggccgggac ttgtggggtc      720

cttctcctgt cactggttat caccctttac tgcaggagta agaggagcag gctcctgcac      780

agtgactaca tgaacatgac tccccgccgc cccgggccca cccgcaagca ttaccagccc      840

tatgccccac cacgcgactt cgcagcctat cgctccagag tgaagttcag caggagcgca      900

gacgcccccg cgtaccagca gggccagaac cagctctata acgagctcaa tctaggacga      960

agagaggagt acgatgtttt ggacaagaga cgtggccggg accctgagat ggggggaaag     1020

ccgagaagga agaaccctca ggaaggcctg tacaatgaac tgcagaaaga taagatggcg     1080

gaggcctaca gtgagattgg gatgaaaggc gagcgccgga ggggcaaggg gcacgatggc     1140

ctttaccagg gtctcagtac agccaccaag gacacctacg acgcccttca catgcaggcc     1200

ctgccccctc gctaagttta aac                                             1223


<210>  78
<211>  397
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  78

Met Tyr Leu Trp Leu Lys Leu Leu Ala Phe Gly Phe Ala Phe Leu Asp 
1               5                   10                  15      


Thr Glu Val Phe Val Thr Gly Ala Val Gln Gly Pro Glu Glu Thr Val 
            20                  25                  30          


Thr Gln Asp Cys Leu Gln Leu Ile Ala Asp Ser Glu Thr Pro Thr Ile 
        35                  40                  45              


Gln Lys Gly Ser Tyr Thr Phe Val Pro Trp Leu Leu Ser Phe Lys Arg 
    50                  55                  60                  


Gly Ser Ala Leu Glu Glu Lys Glu Asn Lys Ile Leu Val Lys Glu Thr 
65                  70                  75                  80  


Gly Tyr Phe Phe Ile Tyr Gly Gln Val Leu Tyr Thr Asp Lys Thr Tyr 
                85                  90                  95      


Ala Met Gly His Leu Ile Gln Arg Lys Lys Val His Val Phe Gly Asp 
            100                 105                 110         


Glu Leu Ser Leu Val Thr Leu Phe Arg Cys Ile Gln Asn Met Pro Glu 
        115                 120                 125             


Thr Leu Pro Asn Asn Ser Cys Tyr Ser Ala Gly Ile Ala Lys Leu Glu 
    130                 135                 140                 


Glu Gly Asp Glu Leu Gln Leu Ala Ile Pro Arg Glu Asn Ala Gln Ile 
145                 150                 155                 160 


Ser Leu Asp Gly Asp Val Thr Phe Phe Gly Ala Leu Lys Leu Leu Thr 
                165                 170                 175     


Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser 
            180                 185                 190         


Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly 
        195                 200                 205             


Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp 
    210                 215                 220                 


Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile 
225                 230                 235                 240 


Thr Leu Tyr Cys Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr 
                245                 250                 255     


Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln 
            260                 265                 270         


Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Arg Val Lys 
        275                 280                 285             


Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln 
    290                 295                 300                 


Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu 
305                 310                 315                 320 


Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg 
                325                 330                 335     


Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met 
            340                 345                 350         


Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly 
        355                 360                 365             


Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp 
    370                 375                 380                 


Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
385                 390                 395         


<210>  79
<211>  1214
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  79
gcgatcgctg ccatcgatac catggcctta ccagtgaccg ccttgctcct gccgctggcc       60

ttgctgctcc acgccgccag gccggttcag ggtccagaag aaacagtcac tcaagactgc      120

ttgcaactga ttgcagacag tgaaacacca actatacaaa aaggatctta cacatttgtt      180

ccatggcttc tcagctttaa aaggggaagt gccctagaag aaaaagagaa taaaatattg      240

gtcaaagaaa ctggttactt ttttatatat ggtcaggttt tatatactga taagacctac      300

gccatgggac atctaattca gaggaagaag gtccatgtct ttggggatga attgagtctg      360

gtgactttgt ttcgatgtat tcaaaatatg cctgaaacac tacccaataa ttcctgctat      420

tcagctggca ttgcaaaact ggaagaagga gatgaactcc aacttgcaat accaagagaa      480

aatgcacaaa tatcactgga tggagatgtc acattttttg gtgcattgaa actgctgacc      540

acgacgccag cgccgcgacc accaacaccg gcgcccacca tcgcgtcgca gcccctgtcc      600

ctgcgcccag aggcgtgccg gccagcggcg gggggcgcag tgcacacgag ggggctggac      660

ttcgcctgtg atatctacat ctgggcgccc ttggccggga cttgtggggt ccttctcctg      720

tcactggtta tcacccttta ctgcaggagt aagaggagca ggctcctgca cagtgactac      780

atgaacatga ctccccgccg ccccgggccc acccgcaagc attaccagcc ctatgcccca      840

ccacgcgact tcgcagccta tcgctccaga gtgaagttca gcaggagcgc agacgccccc      900

gcgtaccagc agggccagaa ccagctctat aacgagctca atctaggacg aagagaggag      960

tacgatgttt tggacaagag acgtggccgg gaccctgaga tggggggaaa gccgagaagg     1020

aagaaccctc aggaaggcct gtacaatgaa ctgcagaaag ataagatggc ggaggcctac     1080

agtgagattg ggatgaaagg cgagcgccgg aggggcaagg ggcacgatgg cctttaccag     1140

ggtctcagta cagccaccaa ggacacctac gacgcccttc acatgcaggc cctgccccct     1200

cgctaagttt aaac                                                       1214


<210>  80
<211>  394
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  80

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Val Gln Gly Pro Glu Glu Thr Val Thr Gln Asp 
            20                  25                  30          


Cys Leu Gln Leu Ile Ala Asp Ser Glu Thr Pro Thr Ile Gln Lys Gly 
        35                  40                  45              


Ser Tyr Thr Phe Val Pro Trp Leu Leu Ser Phe Lys Arg Gly Ser Ala 
    50                  55                  60                  


Leu Glu Glu Lys Glu Asn Lys Ile Leu Val Lys Glu Thr Gly Tyr Phe 
65                  70                  75                  80  


Phe Ile Tyr Gly Gln Val Leu Tyr Thr Asp Lys Thr Tyr Ala Met Gly 
                85                  90                  95      


His Leu Ile Gln Arg Lys Lys Val His Val Phe Gly Asp Glu Leu Ser 
            100                 105                 110         


Leu Val Thr Leu Phe Arg Cys Ile Gln Asn Met Pro Glu Thr Leu Pro 
        115                 120                 125             


Asn Asn Ser Cys Tyr Ser Ala Gly Ile Ala Lys Leu Glu Glu Gly Asp 
    130                 135                 140                 


Glu Leu Gln Leu Ala Ile Pro Arg Glu Asn Ala Gln Ile Ser Leu Asp 
145                 150                 155                 160 


Gly Asp Val Thr Phe Phe Gly Ala Leu Lys Leu Leu Thr Thr Thr Pro 
                165                 170                 175     


Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu 
            180                 185                 190         


Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His 
        195                 200                 205             


Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu 
    210                 215                 220                 


Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr 
225                 230                 235                 240 


Cys Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met 
                245                 250                 255     


Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala 
            260                 265                 270         


Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Arg Val Lys Phe Ser Arg 
        275                 280                 285             


Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn 
    290                 295                 300                 


Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg 
305                 310                 315                 320 


Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro 
                325                 330                 335     


Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala 
            340                 345                 350         


Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His 
        355                 360                 365             


Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp 
    370                 375                 380                 


Ala Leu His Met Gln Ala Leu Pro Pro Arg 
385                 390                 


<210>  81
<211>  2039
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  81
gcgatcgctg ccatcgatac catggcctta ccagtgaccg ccttgctcct gccgctggcc       60

ttgctgctcc acgccgccag gccggttcag ggtccagaag aaacagtcac tcaagactgc      120

ttgcaactga ttgcagacag tgaaacacca actatacaaa aaggatctta cacatttgtt      180

ccatggcttc tcagctttaa aaggggaagt gccctagaag aaaaagagaa taaaatattg      240

gtcaaagaaa ctggttactt ttttatatat ggtcaggttt tatatactga taagacctac      300

gccatgggac atctaattca gaggaagaag gtccatgtct ttggggatga attgagtctg      360

gtgactttgt ttcgatgtat tcaaaatatg cctgaaacac tacccaataa ttcctgctat      420

tcagctggca ttgcaaaact ggaagaagga gatgaactcc aacttgcaat accaagagaa      480

aatgcacaaa tatcactgga tggagatgtc acattttttg gtgcattgaa actgctgacc      540

acgacgccag cgccgcgacc accaacaccg gcgcccacca tcgcgtcgca gcccctgtcc      600

ctgcgcccag aggcgtgccg gccagcggcg gggggcgcag tgcacacgag ggggctggac      660

ttcgcctgtg atatctacat ctgggcgccc ttggccggga cttgtggggt ccttctcctg      720

tcactggtta tcacccttta ctgcaggagt aagaggagca ggctcctgca cagtgactac      780

atgaacatga ctccccgccg ccccgggccc acccgcaagc attaccagcc ctatgcccca      840

ccacgcgact tcgcagccta tcgctccaga gtgaagttca gcaggagcgc agacgccccc      900

gcgtaccagc agggccagaa ccagctctat aacgagctca atctaggacg aagagaggag      960

tacgatgttt tggacaagag acgtggccgg gaccctgaga tggggggaaa gccgagaagg     1020

aagaaccctc aggaaggcct gtacaatgaa ctgcagaaag ataagatggc ggaggcctac     1080

agtgagattg ggatgaaagg cgagcgccgg aggggcaagg ggcacgatgg cctttaccag     1140

ggtctcagta cagccaccaa ggacacctac gacgcccttc acatgcaggc cctgccccct     1200

cgcggcagcg gcgaaggccg cggcagcctg ctgacctgcg gcgatgtgga agaaaacccg     1260

ggccccatgg aatacgcctc tgacgcttca ctggaccccg aagccccgtg gcctcccgcg     1320

ccccgcgctc gcgcctgccg cgtactgcct tgggccctgg tcgcggggct gctgctgctg     1380

ctgctgctcg ctgccgcctg cgccgtcttc ctcgcctgcc cctgggccgt gtccggggct     1440

cgcgcctcgc ccggctccgc ggccagcccg agactccgcg agggtcccga gctttcgccc     1500

gacgatcccg ccggcctctt ggacctgcgg cagggcatgt ttgcgcagct ggtggcccaa     1560

aatgttctgc tgatcgatgg gcccctgagc tggtacagtg acccaggcct ggcaggcgtg     1620

tccctgacgg ggggcctgag ctacaaagag gacacgaagg agctggtggt ggccaaggct     1680

ggagtctact atgtcttctt tcaactagag ctgcggcgcg tggtggccgg cgagggctca     1740

ggctccgttt cacttgcgct gcacctgcag ccactgcgct ctgctgctgg ggccgccgcc     1800

ctggctttga ccgtggacct gccacccgcc tcctccgagg ctcggaactc ggccttcggt     1860

ttccagggcc gcttgctgca cctgagtgcc ggccagcgcc tgggcgtcca tcttcacact     1920

gaggccaggg cacgccatgc ctggcagctt acccagggcg ccacagtctt gggactcttc     1980

cgggtgaccc ccgaaatccc agccggactc ccttcaccga ggtcggaata agtttaaac      2039


<210>  82
<211>  669
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  82

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Val Gln Gly Pro Glu Glu Thr Val Thr Gln Asp 
            20                  25                  30          


Cys Leu Gln Leu Ile Ala Asp Ser Glu Thr Pro Thr Ile Gln Lys Gly 
        35                  40                  45              


Ser Tyr Thr Phe Val Pro Trp Leu Leu Ser Phe Lys Arg Gly Ser Ala 
    50                  55                  60                  


Leu Glu Glu Lys Glu Asn Lys Ile Leu Val Lys Glu Thr Gly Tyr Phe 
65                  70                  75                  80  


Phe Ile Tyr Gly Gln Val Leu Tyr Thr Asp Lys Thr Tyr Ala Met Gly 
                85                  90                  95      


His Leu Ile Gln Arg Lys Lys Val His Val Phe Gly Asp Glu Leu Ser 
            100                 105                 110         


Leu Val Thr Leu Phe Arg Cys Ile Gln Asn Met Pro Glu Thr Leu Pro 
        115                 120                 125             


Asn Asn Ser Cys Tyr Ser Ala Gly Ile Ala Lys Leu Glu Glu Gly Asp 
    130                 135                 140                 


Glu Leu Gln Leu Ala Ile Pro Arg Glu Asn Ala Gln Ile Ser Leu Asp 
145                 150                 155                 160 


Gly Asp Val Thr Phe Phe Gly Ala Leu Lys Leu Leu Thr Thr Thr Pro 
                165                 170                 175     


Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu 
            180                 185                 190         


Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His 
        195                 200                 205             


Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu 
    210                 215                 220                 


Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr 
225                 230                 235                 240 


Cys Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met 
                245                 250                 255     


Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala 
            260                 265                 270         


Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Arg Val Lys Phe Ser Arg 
        275                 280                 285             


Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn 
    290                 295                 300                 


Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg 
305                 310                 315                 320 


Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro 
                325                 330                 335     


Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala 
            340                 345                 350         


Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His 
        355                 360                 365             


Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp 
    370                 375                 380                 


Ala Leu His Met Gln Ala Leu Pro Pro Arg Gly Ser Gly Glu Gly Arg 
385                 390                 395                 400 


Gly Ser Leu Leu Thr Cys Gly Asp Val Glu Glu Asn Pro Gly Pro Met 
                405                 410                 415     


Glu Tyr Ala Ser Asp Ala Ser Leu Asp Pro Glu Ala Pro Trp Pro Pro 
            420                 425                 430         


Ala Pro Arg Ala Arg Ala Cys Arg Val Leu Pro Trp Ala Leu Val Ala 
        435                 440                 445             


Gly Leu Leu Leu Leu Leu Leu Leu Ala Ala Ala Cys Ala Val Phe Leu 
    450                 455                 460                 


Ala Cys Pro Trp Ala Val Ser Gly Ala Arg Ala Ser Pro Gly Ser Ala 
465                 470                 475                 480 


Ala Ser Pro Arg Leu Arg Glu Gly Pro Glu Leu Ser Pro Asp Asp Pro 
                485                 490                 495     


Ala Gly Leu Leu Asp Leu Arg Gln Gly Met Phe Ala Gln Leu Val Ala 
            500                 505                 510         


Gln Asn Val Leu Leu Ile Asp Gly Pro Leu Ser Trp Tyr Ser Asp Pro 
        515                 520                 525             


Gly Leu Ala Gly Val Ser Leu Thr Gly Gly Leu Ser Tyr Lys Glu Asp 
    530                 535                 540                 


Thr Lys Glu Leu Val Val Ala Lys Ala Gly Val Tyr Tyr Val Phe Phe 
545                 550                 555                 560 


Gln Leu Glu Leu Arg Arg Val Val Ala Gly Glu Gly Ser Gly Ser Val 
                565                 570                 575     


Ser Leu Ala Leu His Leu Gln Pro Leu Arg Ser Ala Ala Gly Ala Ala 
            580                 585                 590         


Ala Leu Ala Leu Thr Val Asp Leu Pro Pro Ala Ser Ser Glu Ala Arg 
        595                 600                 605             


Asn Ser Ala Phe Gly Phe Gln Gly Arg Leu Leu His Leu Ser Ala Gly 
    610                 615                 620                 


Gln Arg Leu Gly Val His Leu His Thr Glu Ala Arg Ala Arg His Ala 
625                 630                 635                 640 


Trp Gln Leu Thr Gln Gly Ala Thr Val Leu Gly Leu Phe Arg Val Thr 
                645                 650                 655     


Pro Glu Ile Pro Ala Gly Leu Pro Ser Pro Arg Ser Glu 
            660                 665                 


<210>  83
<211>  2096
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  83
gcgatcgctg ccatcgatac catggcctta ccagtgaccg ccttgctcct gccgctggcc       60

ttgctgctcc acgccgccag gccggttcag ggtccagaag aaacagtcac tcaagactgc      120

ttgcaactga ttgcagacag tgaaacacca actatacaaa aaggatctta cacatttgtt      180

ccatggcttc tcagctttaa aaggggaagt gccctagaag aaaaagagaa taaaatattg      240

gtcaaagaaa ctggttactt ttttatatat ggtcaggttt tatatactga taagacctac      300

gccatgggac atctaattca gaggaagaag gtccatgtct ttggggatga attgagtctg      360

gtgactttgt ttcgatgtat tcaaaatatg cctgaaacac tacccaataa ttcctgctat      420

tcagctggca ttgcaaaact ggaagaagga gatgaactcc aacttgcaat accaagagaa      480

aatgcacaaa tatcactgga tggagatgtc acattttttg gtgcattgaa actgctgacc      540

acgacgccag cgccgcgacc accaacaccg gcgcccacca tcgcgtcgca gcccctgtcc      600

ctgcgcccag aggcgtgccg gccagcggcg gggggcgcag tgcacacgag ggggctggac      660

ttcgcctgtg atatctacat ctgggcgccc ttggccggga cttgtggggt ccttctcctg      720

tcactggtta tcacccttta ctgcaggagt aagaggagca ggctcctgca cagtgactac      780

atgaacatga ctccccgccg ccccgggccc acccgcaagc attaccagcc ctatgcccca      840

ccacgcgact tcgcagccta tcgctccaga gtgaagttca gcaggagcgc agacgccccc      900

gcgtaccagc agggccagaa ccagctctat aacgagctca atctaggacg aagagaggag      960

tacgatgttt tggacaagag acgtggccgg gaccctgaga tggggggaaa gccgagaagg     1020

aagaaccctc aggaaggcct gtacaatgaa ctgcagaaag ataagatggc ggaggcctac     1080

agtgagattg ggatgaaagg cgagcgccgg aggggcaagg ggcacgatgg cctttaccag     1140

ggtctcagta cagccaccaa ggacacctac gacgcccttc acatgcaggc cctgccccct     1200

cgcggcagcg gcgaaggccg cggcagcctg ctgacctgcg gcgatgtgga agaaaacccg     1260

ggccccatgt acagaatgca gctgctgagc tgcatcgccc tgagcctggc cctggtgacc     1320

aacagcggca tccacgtgtt catcctgggc tgcttcagcg ccggcctgcc caagaccgag     1380

gccaactggg tgaacgtgat cagcgacctg aagaagatcg aggacctgat ccagagcatg     1440

cacatcgacg ccaccctgta caccgagagc gacgtgcacc ccagctgcaa ggtgaccgcc     1500

atgaagtgct tcctgctgga gctgcaggtg atcagcctgg agagcggcga cgccagcatc     1560

cacgacaccg tggagaacct gatcatcctg gccaacaaca gcctgagcag caacggcaac     1620

gtgaccgaga gcggctgcaa ggagtgcgag gagctggagg agaagaacat caaggagttc     1680

ctgcagagct tcgtgcacat cgtgcagatg ttcatcaaca ccagctccgg cggcggctcc     1740

ggcggcggcg gctccggcgg cggcggctcc ggcggcggcg gctccggcgg cggctccctg     1800

caggccccca gaagagccag aggctgcaga accctgggcc tgcccgccct gctgctgctg     1860

ctgctgctga gaccccccgc caccagaggc atcacctgcc ccccccccat gagcgtggag     1920

cacgccgaca tctgggtgaa gagctacagc ctgtacagca gagagagata catctgcaac     1980

agcggcttca agagaaaggc cggcaccagc agcctgaccg agtgcgtgct gaacaaggcc     2040

accaacgtgg cccactggac cacccccagc ctgaagtgca tcagataagt ttaaac         2096


<210>  84
<211>  688
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  84

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Val Gln Gly Pro Glu Glu Thr Val Thr Gln Asp 
            20                  25                  30          


Cys Leu Gln Leu Ile Ala Asp Ser Glu Thr Pro Thr Ile Gln Lys Gly 
        35                  40                  45              


Ser Tyr Thr Phe Val Pro Trp Leu Leu Ser Phe Lys Arg Gly Ser Ala 
    50                  55                  60                  


Leu Glu Glu Lys Glu Asn Lys Ile Leu Val Lys Glu Thr Gly Tyr Phe 
65                  70                  75                  80  


Phe Ile Tyr Gly Gln Val Leu Tyr Thr Asp Lys Thr Tyr Ala Met Gly 
                85                  90                  95      


His Leu Ile Gln Arg Lys Lys Val His Val Phe Gly Asp Glu Leu Ser 
            100                 105                 110         


Leu Val Thr Leu Phe Arg Cys Ile Gln Asn Met Pro Glu Thr Leu Pro 
        115                 120                 125             


Asn Asn Ser Cys Tyr Ser Ala Gly Ile Ala Lys Leu Glu Glu Gly Asp 
    130                 135                 140                 


Glu Leu Gln Leu Ala Ile Pro Arg Glu Asn Ala Gln Ile Ser Leu Asp 
145                 150                 155                 160 


Gly Asp Val Thr Phe Phe Gly Ala Leu Lys Leu Leu Thr Thr Thr Pro 
                165                 170                 175     


Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu 
            180                 185                 190         


Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His 
        195                 200                 205             


Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu 
    210                 215                 220                 


Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr 
225                 230                 235                 240 


Cys Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met 
                245                 250                 255     


Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala 
            260                 265                 270         


Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Arg Val Lys Phe Ser Arg 
        275                 280                 285             


Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn 
    290                 295                 300                 


Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg 
305                 310                 315                 320 


Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro 
                325                 330                 335     


Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala 
            340                 345                 350         


Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His 
        355                 360                 365             


Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp 
    370                 375                 380                 


Ala Leu His Met Gln Ala Leu Pro Pro Arg Gly Ser Gly Glu Gly Arg 
385                 390                 395                 400 


Gly Ser Leu Leu Thr Cys Gly Asp Val Glu Glu Asn Pro Gly Pro Met 
                405                 410                 415     


Tyr Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu Val 
            420                 425                 430         


Thr Asn Ser Gly Ile His Val Phe Ile Leu Gly Cys Phe Ser Ala Gly 
        435                 440                 445             


Leu Pro Lys Thr Glu Ala Asn Trp Val Asn Val Ile Ser Asp Leu Lys 
    450                 455                 460                 


Lys Ile Glu Asp Leu Ile Gln Ser Met His Ile Asp Ala Thr Leu Tyr 
465                 470                 475                 480 


Thr Glu Ser Asp Val His Pro Ser Cys Lys Val Thr Ala Met Lys Cys 
                485                 490                 495     


Phe Leu Leu Glu Leu Gln Val Ile Ser Leu Glu Ser Gly Asp Ala Ser 
            500                 505                 510         


Ile His Asp Thr Val Glu Asn Leu Ile Ile Leu Ala Asn Asn Ser Leu 
        515                 520                 525             


Ser Ser Asn Gly Asn Val Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu 
    530                 535                 540                 


Leu Glu Glu Lys Asn Ile Lys Glu Phe Leu Gln Ser Phe Val His Ile 
545                 550                 555                 560 


Val Gln Met Phe Ile Asn Thr Ser Ser Gly Gly Gly Ser Gly Gly Gly 
                565                 570                 575     


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser 
            580                 585                 590         


Leu Gln Ala Pro Arg Arg Ala Arg Gly Cys Arg Thr Leu Gly Leu Pro 
        595                 600                 605             


Ala Leu Leu Leu Leu Leu Leu Leu Arg Pro Pro Ala Thr Arg Gly Ile 
    610                 615                 620                 


Thr Cys Pro Pro Pro Met Ser Val Glu His Ala Asp Ile Trp Val Lys 
625                 630                 635                 640 


Ser Tyr Ser Leu Tyr Ser Arg Glu Arg Tyr Ile Cys Asn Ser Gly Phe 
                645                 650                 655     


Lys Arg Lys Ala Gly Thr Ser Ser Leu Thr Glu Cys Val Leu Asn Lys 
            660                 665                 670         


Ala Thr Asn Val Ala His Trp Thr Thr Pro Ser Leu Lys Cys Ile Arg 
        675                 680                 685             


<210>  85
<211>  2755
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  85
gcgatcgcac catggccctg cccgtgaccg ccctgctgct gcccctggcc ctgctgctgc       60

acgccgccag gcccgccgtt cagggtccag aagaaacagt cactcaagac tgcttgcaac      120

tgattgcaga cagtgaaaca ccaactatac aaaaaggatc ttacacattt gttccatggc      180

ttctcagctt taaaagggga agtgccctag aagaaaaaga gaataaaata ttggtcaaag      240

aaactggtta cttttttata tatggtcagg ttttatatac tgataagacc tacgccatgg      300

gacatctaat tcagaggaag aaggtccatg tctttgggga tgaattgagt ctggtgactt      360

tgtttcgatg tattcaaaat atgcctgaaa cactacccaa taattcctgc tattcagctg      420

gcattgcaaa actggaagaa ggagatgaac tccaacttgc aataccaaga gaaaatgcac      480

aaatatcact ggatggagat gtcacatttt ttggtgcatt gaaactgctg accacgacgc      540

cagcgccgcg accaccaaca ccggcgccca ccatcgcgtc gcagcccctg tccctgcgcc      600

cagaggcgtg ccggccagcg gcggggggcg cagtgcacac gagggggctg gacttcgcct      660

gtgatatcta catctgggcg cccttggccg ggacttgtgg ggtccttctc ctgtcactgg      720

ttatcaccct ttactgcagg agtaagagga gcaggctcct gcacagtgac tacatgaaca      780

tgactccccg ccgccccggg cccacccgca agcattacca gccctatgcc ccaccacgcg      840

acttcgcagc ctatcgctcc agagtgaagt tcagcaggag cgcagacgcc cccgcgtacc      900

agcagggcca gaaccagctc tataacgagc tcaatctagg acgaagagag gagtacgatg      960

ttttggacaa gagacgtggc cgggaccctg agatgggggg aaagccgaga aggaagaacc     1020

ctcaggaagg cctgtacaat gaactgcaga aagataagat ggcggaggcc tacagtgaga     1080

ttgggatgaa aggcgagcgc cggaggggca aggggcacga tggcctttac cagggtctca     1140

gtacagccac caaggacacc tacgacgccc ttcacatgca ggccctgccc cctcgcggaa     1200

gcggagccac caacttcagc ctgctgaagc aggccggcga cgtggaggag aaccccggcc     1260

ccatggcctt accagtgacc gccttgctcc tgccgctggc cttgctgctc cacgccgcca     1320

ggccggaggt ccagctgcag cagtctggac ctgagctgat aaagcctggg gcttcagtga     1380

agatgtcctg caaggcttct ggatacacat tcactagcta tgttatgcac tgggtgaagc     1440

agaagcctgg gcagggcctt gagtggattg gatatattaa tccttacaat gatggtacta     1500

agtacaatga gaagttcaaa ggcaaggcca cactgacttc agacaaatcc tccagcacag     1560

cctacatgga gctcagcagc ctgacctctg aggactctgc ggtctattac tgtgcaagag     1620

ggacttatta ctacggtagt agggtatttg actactgggg ccaaggcacc actctcacag     1680

tctcctcagg tggagggggc tcaggcggag gtggctctgg gggtggaggc tcggacattg     1740

tgatgactca ggctgcaccc tctatacctg tcactcctgg agagtcagta tccatctcct     1800

gcaggtctag taagagtctc ctgaatagta atggcaacac ttacttgtat tggttcctgc     1860

agaggccagg ccagtctcct cagctcctga tatatcggat gtccaacctt gcctcaggag     1920

tcccagacag gttcagtggc agtgggtcag gaactgcttt cacactgaga atcagtagag     1980

tggaggctga ggatgtgggt gtttattact gtatgcaaca tctagaatat ccgttcacgt     2040

tcggtgctgg gaccaagctg gagctgaaac ggaccacgac gccagcgccg cgaccaccaa     2100

caccggcgcc caccatcgcg tcgcagcccc tgtccctgcg cccagaggcg tgccggccag     2160

cggcgggggg cgcagtgcac acgagggggc tggacttcgc ctgtgatatc tacatctggg     2220

cgcccttggc cgggacttgt ggggtccttc tcctgtcact ggttatcacc ctttactgca     2280

aacggggcag aaagaaactc ctgtatatat tcaaacaacc atttatgaga ccagtacaaa     2340

ctactcaaga ggaagatggc tgtagctgcc gatttccaga agaagaagaa ggaggatgtg     2400

aactgagagt gaagttcagc aggagcgcag acgcccccgc gtaccagcag ggccagaacc     2460

agctctataa cgagctcaat ctaggacgaa gagaggagta cgatgttttg gacaagagac     2520

gtggccggga ccctgagatg gggggaaagc cgcagagaag gaagaaccct caggaaggcc     2580

tgtacaatga actgcagaaa gataagatgg cggaggccta cagtgagatt gggatgaaag     2640

gcgagcgccg gaggggcaag gggcacgatg gcctttacca gggtctcagt acagccacca     2700

aggacaccta cgacgccctt cacatgcagg ccctgccccc tcgctaagtt taaac          2755


<210>  86
<211>  911
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  86

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Ala Val Gln Gly Pro Glu Glu Thr Val Thr Gln 
            20                  25                  30          


Asp Cys Leu Gln Leu Ile Ala Asp Ser Glu Thr Pro Thr Ile Gln Lys 
        35                  40                  45              


Gly Ser Tyr Thr Phe Val Pro Trp Leu Leu Ser Phe Lys Arg Gly Ser 
    50                  55                  60                  


Ala Leu Glu Glu Lys Glu Asn Lys Ile Leu Val Lys Glu Thr Gly Tyr 
65                  70                  75                  80  


Phe Phe Ile Tyr Gly Gln Val Leu Tyr Thr Asp Lys Thr Tyr Ala Met 
                85                  90                  95      


Gly His Leu Ile Gln Arg Lys Lys Val His Val Phe Gly Asp Glu Leu 
            100                 105                 110         


Ser Leu Val Thr Leu Phe Arg Cys Ile Gln Asn Met Pro Glu Thr Leu 
        115                 120                 125             


Pro Asn Asn Ser Cys Tyr Ser Ala Gly Ile Ala Lys Leu Glu Glu Gly 
    130                 135                 140                 


Asp Glu Leu Gln Leu Ala Ile Pro Arg Glu Asn Ala Gln Ile Ser Leu 
145                 150                 155                 160 


Asp Gly Asp Val Thr Phe Phe Gly Ala Leu Lys Leu Leu Thr Thr Thr 
                165                 170                 175     


Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro 
            180                 185                 190         


Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val 
        195                 200                 205             


His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro 
    210                 215                 220                 


Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu 
225                 230                 235                 240 


Tyr Cys Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn 
                245                 250                 255     


Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr 
            260                 265                 270         


Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Arg Val Lys Phe Ser 
        275                 280                 285             


Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr 
    290                 295                 300                 


Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys 
305                 310                 315                 320 


Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn 
                325                 330                 335     


Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu 
            340                 345                 350         


Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly 
        355                 360                 365             


His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr 
    370                 375                 380                 


Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg Gly Ser Gly Ala Thr 
385                 390                 395                 400 


Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly 
                405                 410                 415     


Pro Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu 
            420                 425                 430         


Leu His Ala Ala Arg Pro Glu Val Gln Leu Gln Gln Ser Gly Pro Glu 
        435                 440                 445             


Leu Ile Lys Pro Gly Ala Ser Val Lys Met Ser Cys Lys Ala Ser Gly 
    450                 455                 460                 


Tyr Thr Phe Thr Ser Tyr Val Met His Trp Val Lys Gln Lys Pro Gly 
465                 470                 475                 480 


Gln Gly Leu Glu Trp Ile Gly Tyr Ile Asn Pro Tyr Asn Asp Gly Thr 
                485                 490                 495     


Lys Tyr Asn Glu Lys Phe Lys Gly Lys Ala Thr Leu Thr Ser Asp Lys 
            500                 505                 510         


Ser Ser Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Thr Ser Glu Asp 
        515                 520                 525             


Ser Ala Val Tyr Tyr Cys Ala Arg Gly Thr Tyr Tyr Tyr Gly Ser Arg 
    530                 535                 540                 


Val Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser Gly 
545                 550                 555                 560 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile 
                565                 570                 575     


Val Met Thr Gln Ala Ala Pro Ser Ile Pro Val Thr Pro Gly Glu Ser 
            580                 585                 590         


Val Ser Ile Ser Cys Arg Ser Ser Lys Ser Leu Leu Asn Ser Asn Gly 
        595                 600                 605             


Asn Thr Tyr Leu Tyr Trp Phe Leu Gln Arg Pro Gly Gln Ser Pro Gln 
    610                 615                 620                 


Leu Leu Ile Tyr Arg Met Ser Asn Leu Ala Ser Gly Val Pro Asp Arg 
625                 630                 635                 640 


Phe Ser Gly Ser Gly Ser Gly Thr Ala Phe Thr Leu Arg Ile Ser Arg 
                645                 650                 655     


Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln His Leu Glu 
            660                 665                 670         


Tyr Pro Phe Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Arg Thr 
        675                 680                 685             


Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser 
    690                 695                 700                 


Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly 
705                 710                 715                 720 


Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp 
                725                 730                 735     


Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile 
            740                 745                 750         


Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys 
        755                 760                 765             


Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys 
    770                 775                 780                 


Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val 
785                 790                 795                 800 


Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn 
                805                 810                 815     


Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val 
            820                 825                 830         


Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Gln 
        835                 840                 845             


Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp 
    850                 855                 860                 


Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg 
865                 870                 875                 880 


Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr 
                885                 890                 895     


Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            900                 905                 910     


<210>  87
<211>  2734
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  87
gcgatcgcac catggcctta ccagtgaccg ccttgctcct gccgctggcc ttgctgctcc       60

acgccgccag gccggtgctc acccaaaaac agaagaagca gcactctgtc ctgcacctgg      120

ttcccattaa cgccacctcc aaggatgact ccgatgtgac agaggtgatg tggcaaccag      180

ctcttaggcg tgggagaggc ctacaggccc aaggatatgg tgtccgaatc caggatgctg      240

gagtttatct gctgtatagc caggtcctgt ttcaagacgt gactttcacc atgggtcagg      300

tggtgtctcg agaaggccaa ggaaggcagg agactctatt ccgatgtata agaagtatgc      360

cctcccaccc ggaccgggcc tacaacagct gctatagcgc aggtgtcttc catttacacc      420

aaggggatat tctgagtgtc ataattcccc gggcaagggc gaaacttaac ctctctccac      480

atggaacctt cctggggttt gtgaaactga ccacgacgcc agcgccgcga ccaccaacac      540

cggcgcccac catcgcgtcg cagcccctgt ccctgcgccc agaggcgtgc cggccagcgg      600

cggggggcgc agtgcacacg agggggctgg acttcgcctg tgatatctac atctgggcgc      660

ccttggccgg gacttgtggg gtccttctcc tgtcactggt tatcaccctt tactgcagga      720

gtaagaggag caggctcctg cacagtgact acatgaacat gactccccgc cgccccgggc      780

ccacccgcaa gcattaccag ccctatgccc caccacgcga cttcgcagcc tatcgctcca      840

gagtgaagtt cagcaggagc gcagacgccc ccgcgtacca gcagggccag aaccagctct      900

ataacgagct caatctagga cgaagagagg agtacgatgt tttggacaag agacgtggcc      960

gggaccctga gatgggggga aagccgagaa ggaagaaccc tcaggaaggc ctgtacaatg     1020

aactgcagaa agataagatg gcggaggcct acagtgagat tgggatgaaa ggcgagcgcc     1080

ggaggggcaa ggggcacgat ggcctttacc agggtctcag tacagccacc aaggacacct     1140

acgacgccct tcacatgcag gccctgcccc ctcgcggaag cggagccacc aacttcagcc     1200

tgctgaagca ggccggcgac gtggaggaga accccggccc catggcctta ccagtgaccg     1260

ccttgctcct gccgctggcc ttgctgctcc acgccgccag gccggaggtc cagctgcagc     1320

agtctggacc tgagctgata aagcctgggg cttcagtgaa gatgtcctgc aaggcttctg     1380

gatacacatt cactagctat gttatgcact gggtgaagca gaagcctggg cagggccttg     1440

agtggattgg atatattaat ccttacaatg atggtactaa gtacaatgag aagttcaaag     1500

gcaaggccac actgacttca gacaaatcct ccagcacagc ctacatggag ctcagcagcc     1560

tgacctctga ggactctgcg gtctattact gtgcaagagg gacttattac tacggtagta     1620

gggtatttga ctactggggc caaggcacca ctctcacagt ctcctcaggt ggagggggct     1680

caggcggagg tggctctggg ggtggaggct cggacattgt gatgactcag gctgcaccct     1740

ctatacctgt cactcctgga gagtcagtat ccatctcctg caggtctagt aagagtctcc     1800

tgaatagtaa tggcaacact tacttgtatt ggttcctgca gaggccaggc cagtctcctc     1860

agctcctgat atatcggatg tccaaccttg cctcaggagt cccagacagg ttcagtggca     1920

gtgggtcagg aactgctttc acactgagaa tcagtagagt ggaggctgag gatgtgggtg     1980

tttattactg tatgcaacat ctagaatatc cgttcacgtt cggtgctggg accaagctgg     2040

agctgaaacg gaccacgacg ccagcgccgc gaccaccaac accggcgccc accatcgcgt     2100

cgcagcccct gtccctgcgc ccagaggcgt gccggccagc ggcggggggc gcagtgcaca     2160

cgagggggct ggacttcgcc tgtgatatct acatctgggc gcccttggcc gggacttgtg     2220

gggtccttct cctgtcactg gttatcaccc tttactgcaa acggggcaga aagaaactcc     2280

tgtatatatt caaacaacca tttatgagac cagtacaaac tactcaagag gaagatggct     2340

gtagctgccg atttccagaa gaagaagaag gaggatgtga actgagagtg aagttcagca     2400

ggagcgcaga cgcccccgcg taccagcagg gccagaacca gctctataac gagctcaatc     2460

taggacgaag agaggagtac gatgttttgg acaagagacg tggccgggac cctgagatgg     2520

ggggaaagcc gcagagaagg aagaaccctc aggaaggcct gtacaatgaa ctgcagaaag     2580

ataagatggc ggaggcctac agtgagattg ggatgaaagg cgagcgccgg aggggcaagg     2640

ggcacgatgg cctttaccag ggtctcagta cagccaccaa ggacacctac gacgcccttc     2700

acatgcaggc cctgccccct cgctaagttt aaac                                 2734


<210>  88
<211>  904
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  88

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Val Leu Thr Gln Lys Gln Lys Lys Gln His Ser 
            20                  25                  30          


Val Leu His Leu Val Pro Ile Asn Ala Thr Ser Lys Asp Asp Ser Asp 
        35                  40                  45              


Val Thr Glu Val Met Trp Gln Pro Ala Leu Arg Arg Gly Arg Gly Leu 
    50                  55                  60                  


Gln Ala Gln Gly Tyr Gly Val Arg Ile Gln Asp Ala Gly Val Tyr Leu 
65                  70                  75                  80  


Leu Tyr Ser Gln Val Leu Phe Gln Asp Val Thr Phe Thr Met Gly Gln 
                85                  90                  95      


Val Val Ser Arg Glu Gly Gln Gly Arg Gln Glu Thr Leu Phe Arg Cys 
            100                 105                 110         


Ile Arg Ser Met Pro Ser His Pro Asp Arg Ala Tyr Asn Ser Cys Tyr 
        115                 120                 125             


Ser Ala Gly Val Phe His Leu His Gln Gly Asp Ile Leu Ser Val Ile 
    130                 135                 140                 


Ile Pro Arg Ala Arg Ala Lys Leu Asn Leu Ser Pro His Gly Thr Phe 
145                 150                 155                 160 


Leu Gly Phe Val Lys Leu Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr 
                165                 170                 175     


Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala 
            180                 185                 190         


Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe 
        195                 200                 205             


Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val 
    210                 215                 220                 


Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Arg Ser Lys Arg Ser 
225                 230                 235                 240 


Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly 
                245                 250                 255     


Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala 
            260                 265                 270         


Ala Tyr Arg Ser Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala 
        275                 280                 285             


Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg 
    290                 295                 300                 


Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu 
305                 310                 315                 320 


Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn 
                325                 330                 335     


Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met 
            340                 345                 350         


Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly 
        355                 360                 365             


Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala 
    370                 375                 380                 


Leu Pro Pro Arg Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln 
385                 390                 395                 400 


Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met Ala Leu Pro Val Thr 
                405                 410                 415     


Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu His Ala Ala Arg Pro Glu 
            420                 425                 430         


Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Ile Lys Pro Gly Ala Ser 
        435                 440                 445             


Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr Val 
    450                 455                 460                 


Met His Trp Val Lys Gln Lys Pro Gly Gln Gly Leu Glu Trp Ile Gly 
465                 470                 475                 480 


Tyr Ile Asn Pro Tyr Asn Asp Gly Thr Lys Tyr Asn Glu Lys Phe Lys 
                485                 490                 495     


Gly Lys Ala Thr Leu Thr Ser Asp Lys Ser Ser Ser Thr Ala Tyr Met 
            500                 505                 510         


Glu Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys Ala 
        515                 520                 525             


Arg Gly Thr Tyr Tyr Tyr Gly Ser Arg Val Phe Asp Tyr Trp Gly Gln 
    530                 535                 540                 


Gly Thr Thr Leu Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
545                 550                 555                 560 


Gly Ser Gly Gly Gly Gly Ser Asp Ile Val Met Thr Gln Ala Ala Pro 
                565                 570                 575     


Ser Ile Pro Val Thr Pro Gly Glu Ser Val Ser Ile Ser Cys Arg Ser 
            580                 585                 590         


Ser Lys Ser Leu Leu Asn Ser Asn Gly Asn Thr Tyr Leu Tyr Trp Phe 
        595                 600                 605             


Leu Gln Arg Pro Gly Gln Ser Pro Gln Leu Leu Ile Tyr Arg Met Ser 
    610                 615                 620                 


Asn Leu Ala Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly 
625                 630                 635                 640 


Thr Ala Phe Thr Leu Arg Ile Ser Arg Val Glu Ala Glu Asp Val Gly 
                645                 650                 655     


Val Tyr Tyr Cys Met Gln His Leu Glu Tyr Pro Phe Thr Phe Gly Ala 
            660                 665                 670         


Gly Thr Lys Leu Glu Leu Lys Arg Thr Thr Thr Pro Ala Pro Arg Pro 
        675                 680                 685             


Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro 
    690                 695                 700                 


Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu 
705                 710                 715                 720 


Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys 
                725                 730                 735     


Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly 
            740                 745                 750         


Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val 
        755                 760                 765             


Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu 
    770                 775                 780                 


Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp 
785                 790                 795                 800 


Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn 
                805                 810                 815     


Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg 
            820                 825                 830         


Asp Pro Glu Met Gly Gly Lys Pro Gln Arg Arg Lys Asn Pro Gln Glu 
        835                 840                 845             


Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser 
    850                 855                 860                 


Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly 
865                 870                 875                 880 


Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu 
                885                 890                 895     


His Met Gln Ala Leu Pro Pro Arg 
            900                 


<210>  89
<211>  1498
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  89
gcgatcgcat ggccttacca gtgaccgcct tgctcctgcc gctggccttg ctgctccacg       60

ccgccaggcc ggacatcgtg atgacccaaa gccccgacag cctggccgtg agcctgggcg      120

agagggtgac catgaactgc aaaagcagcc agtccctgct gtactccacc aaccagaaga      180

actacctggc ttggtatcaa cagaagcccg gacagagccc caagctgctg atctattggg      240

ccagcactag ggaaagcggc gtgcccgata ggttcagcgg cagcgggagc ggcacagact      300

tcactctgac cattagcagc gtgcaggctg aggatgtggc cgtctactac tgccagcagt      360

actacagcta caggaccttt gggggcggaa ctaagctgga gatcaaggga ggggggggat      420

ccgggggagg aggctccggc ggaggcggaa gccaagtgca actgcagcag agcggcccag      480

aggtggtcaa acctggggca agcgtgaaga tgagctgcaa ggctagcggc tataccttca      540

ccagctatgt gatccactgg gtgaggcaga aaccaggaca gggcctggac tggatcggct      600

acatcaaccc ctacaatgac ggcaccgatt atgacgaaaa attcaagggg aaggccaccc      660

tgaccagcga caccagcaca agcaccgcct acatggagct gtccagcctg aggtccgagg      720

acaccgccgt gtattactgt gccagggaga aggacaatta cgccaccggc gcttggttcg      780

cctactgggg ccagggcaca ctggtgacag tgagcagcac cacgacgcca gcgccgcgac      840

caccaacacc ggcgcccacc atcgcgtcgc agcccctgtc cctgcgccca gaggcgtgcc      900

ggccagcggc ggggggcgca gtgcacacga gggggctgga cttcgcctgt gatatctaca      960

tctgggcgcc cttggccggg acttgtgggg tccttctcct gtcactggtt atcacccttt     1020

actgcaggag taagaggagc aggctcctgc acagtgacta catgaacatg actccccgcc     1080

gccccgggcc cacccgcaag cattaccagc cctatgcccc accacgcgac ttcgcagcct     1140

atcgctccag agtgaagttc agcaggagcg cagacgcccc cgcgtaccag cagggccaga     1200

accagctcta taacgagctc aatctaggac gaagagagga gtacgatgtt ttggacaaga     1260

gacgtggccg ggaccctgag atggggggaa agccgcagag aaggaagaac cctcaggaag     1320

gcctgtacaa tgaactgcag aaagataaga tggcggaggc ctacagtgag attgggatga     1380

aaggcgagcg ccggaggggc aaggggcacg atggccttta ccagggtctc agtacagcca     1440

ccaaggacac ctacgacgcc cttcacatgc aggccctgcc ccctcgctaa gtttaaac       1498


<210>  90
<211>  493
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  90

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu 
            20                  25                  30          


Ala Val Ser Leu Gly Glu Arg Val Thr Met Asn Cys Lys Ser Ser Gln 
        35                  40                  45              


Ser Leu Leu Tyr Ser Thr Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln 
    50                  55                  60                  


Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr 
65                  70                  75                  80  


Arg Glu Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr 
                85                  90                  95      


Asp Phe Thr Leu Thr Ile Ser Ser Val Gln Ala Glu Asp Val Ala Val 
            100                 105                 110         


Tyr Tyr Cys Gln Gln Tyr Tyr Ser Tyr Arg Thr Phe Gly Gly Gly Thr 
        115                 120                 125             


Lys Leu Glu Ile Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Val Val 
145                 150                 155                 160 


Lys Pro Gly Ala Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr 
                165                 170                 175     


Phe Thr Ser Tyr Val Ile His Trp Val Arg Gln Lys Pro Gly Gln Gly 
            180                 185                 190         


Leu Asp Trp Ile Gly Tyr Ile Asn Pro Tyr Asn Asp Gly Thr Asp Tyr 
        195                 200                 205             


Asp Glu Lys Phe Lys Gly Lys Ala Thr Leu Thr Ser Asp Thr Ser Thr 
    210                 215                 220                 


Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala 
225                 230                 235                 240 


Val Tyr Tyr Cys Ala Arg Glu Lys Asp Asn Tyr Ala Thr Gly Ala Trp 
                245                 250                 255     


Phe Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Thr Thr 
            260                 265                 270         


Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln 
        275                 280                 285             


Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala 
    290                 295                 300                 


Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala 
305                 310                 315                 320 


Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr 
                325                 330                 335     


Leu Tyr Cys Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met 
            340                 345                 350         


Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro 
        355                 360                 365             


Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Arg Val Lys Phe 
    370                 375                 380                 


Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu 
385                 390                 395                 400 


Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp 
                405                 410                 415     


Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Gln Arg Arg 
            420                 425                 430         


Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met 
        435                 440                 445             


Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly 
    450                 455                 460                 


Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp 
465                 470                 475                 480 


Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
                485                 490             


<210>  91
<211>  2560
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  91
gcgatcgcat gtatttgtgg cttaaactct tggcatttgg ctttgccttt ctggacacag       60

aagtatttgt gacaggggac atcgtgatga cccaaagccc cgacagcctg gccgtgagcc      120

tgggcgagag ggtgaccatg aactgcaaaa gcagccagtc cctgctgtac tccaccaacc      180

agaagaacta cctggcttgg tatcaacaga agcccggaca gagccccaag ctgctgatct      240

attgggccag cactagggaa agcggcgtgc ccgataggtt cagcggcagc gggagcggca      300

cagacttcac tctgaccatt agcagcgtgc aggctgagga tgtggccgtc tactactgcc      360

agcagtacta cagctacagg acctttgggg gcggaactaa gctggagatc aagggagggg      420

ggggatccgg gggaggaggc tccggcggag gcggaagcca agtgcaactg cagcagagcg      480

gcccagaggt ggtcaaacct ggggcaagcg tgaagatgag ctgcaaggct agcggctata      540

ccttcaccag ctatgtgatc cactgggtga ggcagaaacc aggacagggc ctggactgga      600

tcggctacat caacccctac aatgacggca ccgattatga cgaaaaattc aaggggaagg      660

ccaccctgac cagcgacacc agcacaagca ccgcctacat ggagctgtcc agcctgaggt      720

ccgaggacac cgccgtgtat tactgtgcca gggagaagga caattacgcc accggcgctt      780

ggttcgccta ctggggccag ggcacactgg tgacagtgag cagcaccacg acgccagcgc      840

cgcgaccacc aacaccggcg cccaccatcg cgtcgcagcc cctgtccctg cgcccagagg      900

cgtgccggcc agcggcgggg ggcgcagtgc acacgagggg gctggacttc gcctgtgata      960

tctacatctg ggcgcccttg gccgggactt gtggggtcct tctcctgtca ctggttatca     1020

ccctttactg cagagtgaag ttcagcagga gcgcagacgc ccccgcgtac cagcagggcc     1080

agaaccagct ctataacgag ctcaatctag gacgaagaga ggagtacgat gttttggaca     1140

agagacgtgg ccgggaccct gagatggggg gaaagccgag aaggaagaac cctcaggaag     1200

gcctgtacaa tgaactgcag aaagataaga tggcggaggc ctacagtgag attgggatga     1260

aaggcgagcg ccggaggggc aaggggcacg atggccttta ccagggtctc agtacagcca     1320

ccaaggacac ctacgacgcc cttcacatgc aggccctgcc ccctcgcgga agcggagcca     1380

ccaacttcag cctgctgaag caggccggcg acgtggagga gaaccccggc ccctacctgt     1440

ggctgaagct gctggccttc ggcttcgcct tcctggacac cgaggtgttc gtgaccggcg     1500

acatccagat gacccagagc cccagcaccc tgagcgccag cgtgggcgac agggtgacca     1560

tcacctgcag cgccagcagc agcatcagct acatgcactg gtaccagcag aagcccggca     1620

aggcccccaa gctgctgatc tacaccacca gcaacctggc cagcggcgtg cccgccaggt     1680

tcagcggcag cggcagcggc accgagttca ccctgaccat cagcagcctg cagcccgacg     1740

acttcgccac ctactactgc caccagagga gcacctaccc cctgaccttc ggccagggca     1800

ccaaggtgga ggtgaagggc ggcggcggca gcggcggcgg cggcagcggc ggcggcggca     1860

gccaggtgca gctggtgcag agcggcgccg aggtgaagaa gcccggcagc agcgtgaagg     1920

tgagctgcaa ggccagcggc tacaccttca ccagctacag gatgcactgg gtgaggcagg     1980

cccccggcca gggcctggag tggatcggct acatcaaccc cagcaccggc tacaccgagt     2040

acaaccagaa gttcaaggac aaggccacca tcaccgccga cgagagcacc aacaccgcct     2100

acatggagct gagcagcctg aggagcgagg acaccgccgt gtactactgc gccaggggcg     2160

gcggcgtgtt cgactactgg ggccagggca ccctggtgac cgtgagcagc accaccaccc     2220

ccgcccccag gccccccacc cccgccccca ccatcgccag ccagcccctg agcctgaggc     2280

ccgaggcctg caggcccgcc gccggcggcg ccgtgcacac caggggcctg gacttcgcct     2340

gcgacttttg ggtgctggtg gtggttggtg gagtcctggc ttgctatagc ttgctagtaa     2400

cagtggcctt tattattttc tgggtgagga gtaagaggag caggctcctg cacagtgact     2460

acatgaacat gactccccgc cgccccgggc ccacccgcaa gcattaccag ccctatgccc     2520

caccacgcga cttcgcagcc tatcgctcct aagtttaaac                           2560


<210>  92
<211>  847
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  92

Met Tyr Leu Trp Leu Lys Leu Leu Ala Phe Gly Phe Ala Phe Leu Asp 
1               5                   10                  15      


Thr Glu Val Phe Val Thr Gly Asp Ile Val Met Thr Gln Ser Pro Asp 
            20                  25                  30          


Ser Leu Ala Val Ser Leu Gly Glu Arg Val Thr Met Asn Cys Lys Ser 
        35                  40                  45              


Ser Gln Ser Leu Leu Tyr Ser Thr Asn Gln Lys Asn Tyr Leu Ala Trp 
    50                  55                  60                  


Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile Tyr Trp Ala 
65                  70                  75                  80  


Ser Thr Arg Glu Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser 
                85                  90                  95      


Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Val Gln Ala Glu Asp Val 
            100                 105                 110         


Ala Val Tyr Tyr Cys Gln Gln Tyr Tyr Ser Tyr Arg Thr Phe Gly Gly 
        115                 120                 125             


Gly Thr Lys Leu Glu Ile Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Gln Gln Ser Gly Pro Glu 
145                 150                 155                 160 


Val Val Lys Pro Gly Ala Ser Val Lys Met Ser Cys Lys Ala Ser Gly 
                165                 170                 175     


Tyr Thr Phe Thr Ser Tyr Val Ile His Trp Val Arg Gln Lys Pro Gly 
            180                 185                 190         


Gln Gly Leu Asp Trp Ile Gly Tyr Ile Asn Pro Tyr Asn Asp Gly Thr 
        195                 200                 205             


Asp Tyr Asp Glu Lys Phe Lys Gly Lys Ala Thr Leu Thr Ser Asp Thr 
    210                 215                 220                 


Ser Thr Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp 
225                 230                 235                 240 


Thr Ala Val Tyr Tyr Cys Ala Arg Glu Lys Asp Asn Tyr Ala Thr Gly 
                245                 250                 255     


Ala Trp Phe Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
            260                 265                 270         


Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala 
        275                 280                 285             


Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly 
    290                 295                 300                 


Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile 
305                 310                 315                 320 


Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val 
                325                 330                 335     


Ile Thr Leu Tyr Cys Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro 
            340                 345                 350         


Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly 
        355                 360                 365             


Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro 
    370                 375                 380                 


Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr 
385                 390                 395                 400 


Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly 
                405                 410                 415     


Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln 
            420                 425                 430         


Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln 
        435                 440                 445             


Ala Leu Pro Pro Arg Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys 
    450                 455                 460                 


Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Tyr Leu Trp Leu Lys 
465                 470                 475                 480 


Leu Leu Ala Phe Gly Phe Ala Phe Leu Asp Thr Glu Val Phe Val Thr 
                485                 490                 495     


Gly Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val 
            500                 505                 510         


Gly Asp Arg Val Thr Ile Thr Cys Ser Ala Ser Ser Ser Ile Ser Tyr 
        515                 520                 525             


Met His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
    530                 535                 540                 


Tyr Thr Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly 
545                 550                 555                 560 


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
                565                 570                 575     


Asp Asp Phe Ala Thr Tyr Tyr Cys His Gln Arg Ser Thr Tyr Pro Leu 
            580                 585                 590         


Thr Phe Gly Gln Gly Thr Lys Val Glu Val Lys Gly Gly Gly Gly Ser 
        595                 600                 605             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Val Gln 
    610                 615                 620                 


Ser Gly Ala Glu Val Lys Lys Pro Gly Ser Ser Val Lys Val Ser Cys 
625                 630                 635                 640 


Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr Arg Met His Trp Val Arg 
                645                 650                 655     


Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile Gly Tyr Ile Asn Pro Ser 
            660                 665                 670         


Thr Gly Tyr Thr Glu Tyr Asn Gln Lys Phe Lys Asp Lys Ala Thr Ile 
        675                 680                 685             


Thr Ala Asp Glu Ser Thr Asn Thr Ala Tyr Met Glu Leu Ser Ser Leu 
    690                 695                 700                 


Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Gly Gly Gly Val 
705                 710                 715                 720 


Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Thr Thr 
                725                 730                 735     


Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln 
            740                 745                 750         


Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala 
        755                 760                 765             


Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Phe Trp Val Leu Val 
    770                 775                 780                 


Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala 
785                 790                 795                 800 


Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser 
                805                 810                 815     


Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His 
            820                 825                 830         


Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser 
        835                 840                 845         


<210>  93
<211>  2551
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  93
gcgatcgcat ggccttacca gtgaccgcct tgctcctgcc gctggccttg ctgctccacg       60

ccgccaggcc ggacatcgtg atgacccaaa gccccgacag cctggccgtg agcctgggcg      120

agagggtgac catgaactgc aaaagcagcc agtccctgct gtactccacc aaccagaaga      180

actacctggc ttggtatcaa cagaagcccg gacagagccc caagctgctg atctattggg      240

ccagcactag ggaaagcggc gtgcccgata ggttcagcgg cagcgggagc ggcacagact      300

tcactctgac cattagcagc gtgcaggctg aggatgtggc cgtctactac tgccagcagt      360

actacagcta caggaccttt gggggcggaa ctaagctgga gatcaaggga ggggggggat      420

ccgggggagg aggctccggc ggaggcggaa gccaagtgca actgcagcag agcggcccag      480

aggtggtcaa acctggggca agcgtgaaga tgagctgcaa ggctagcggc tataccttca      540

ccagctatgt gatccactgg gtgaggcaga aaccaggaca gggcctggac tggatcggct      600

acatcaaccc ctacaatgac ggcaccgatt atgacgaaaa attcaagggg aaggccaccc      660

tgaccagcga caccagcaca agcaccgcct acatggagct gtccagcctg aggtccgagg      720

acaccgccgt gtattactgt gccagggaga aggacaatta cgccaccggc gcttggttcg      780

cctactgggg ccagggcaca ctggtgacag tgagcagcac cacgacgcca gcgccgcgac      840

caccaacacc ggcgcccacc atcgcgtcgc agcccctgtc cctgcgccca gaggcgtgcc      900

ggccagcggc ggggggcgca gtgcacacga gggggctgga cttcgcctgt gatatctaca      960

tctgggcgcc cttggccggg acttgtgggg tccttctcct gtcactggtt atcacccttt     1020

actgcagagt gaagttcagc aggagcgcag acgcccccgc gtaccagcag ggccagaacc     1080

agctctataa cgagctcaat ctaggacgaa gagaggagta cgatgttttg gacaagagac     1140

gtggccggga ccctgagatg gggggaaagc cgagaaggaa gaaccctcag gaaggcctgt     1200

acaatgaact gcagaaagat aagatggcgg aggcctacag tgagattggg atgaaaggcg     1260

agcgccggag gggcaagggg cacgatggcc tttaccaggg tctcagtaca gccaccaagg     1320

acacctacga cgcccttcac atgcaggccc tgccccctcg cggaagcgga gccaccaact     1380

tcagcctgct gaagcaggcc ggcgacgtgg aggagaaccc cggccccatg gccctgcccg     1440

tgaccgccct gctgctgccc ctggccctgc tgctgcacgc cgccaggccc gacatccaga     1500

tgacccagag ccccagcacc ctgagcgcca gcgtgggcga cagggtgacc atcacctgca     1560

gcgccagcag cagcatcagc tacatgcact ggtaccagca gaagcccggc aaggccccca     1620

agctgctgat ctacaccacc agcaacctgg ccagcggcgt gcccgccagg ttcagcggca     1680

gcggcagcgg caccgagttc accctgacca tcagcagcct gcagcccgac gacttcgcca     1740

cctactactg ccaccagagg agcacctacc ccctgacctt cggccagggc accaaggtgg     1800

aggtgaaggg cggcggcggc agcggcggcg gcggcagcgg cggcggcggc agccaggtgc     1860

agctggtgca gagcggcgcc gaggtgaaga agcccggcag cagcgtgaag gtgagctgca     1920

aggccagcgg ctacaccttc accagctaca ggatgcactg ggtgaggcag gcccccggcc     1980

agggcctgga gtggatcggc tacatcaacc ccagcaccgg ctacaccgag tacaaccaga     2040

agttcaagga caaggccacc atcaccgccg acgagagcac caacaccgcc tacatggagc     2100

tgagcagcct gaggagcgag gacaccgccg tgtactactg cgccaggggc ggcggcgtgt     2160

tcgactactg gggccagggc accctggtga ccgtgagcag caccaccacc cccgccccca     2220

ggccccccac ccccgccccc accatcgcca gccagcccct gagcctgagg cccgaggcct     2280

gcaggcccgc cgccggcggc gccgtgcaca ccaggggcct ggacttcgcc tgcgactttt     2340

gggtgctggt ggtggttggt ggagtcctgg cttgctatag cttgctagta acagtggcct     2400

ttattatttt ctgggtgagg agtaagagga gcaggctcct gcacagtgac tacatgaaca     2460

tgactccccg ccgccccggg cccacccgca agcattacca gccctatgcc ccaccacgcg     2520

acttcgcagc ctatcgctcc taagtttaaa c                                    2551


<210>  94
<211>  844
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  94

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu 
            20                  25                  30          


Ala Val Ser Leu Gly Glu Arg Val Thr Met Asn Cys Lys Ser Ser Gln 
        35                  40                  45              


Ser Leu Leu Tyr Ser Thr Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln 
    50                  55                  60                  


Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr 
65                  70                  75                  80  


Arg Glu Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr 
                85                  90                  95      


Asp Phe Thr Leu Thr Ile Ser Ser Val Gln Ala Glu Asp Val Ala Val 
            100                 105                 110         


Tyr Tyr Cys Gln Gln Tyr Tyr Ser Tyr Arg Thr Phe Gly Gly Gly Thr 
        115                 120                 125             


Lys Leu Glu Ile Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Val Val 
145                 150                 155                 160 


Lys Pro Gly Ala Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr 
                165                 170                 175     


Phe Thr Ser Tyr Val Ile His Trp Val Arg Gln Lys Pro Gly Gln Gly 
            180                 185                 190         


Leu Asp Trp Ile Gly Tyr Ile Asn Pro Tyr Asn Asp Gly Thr Asp Tyr 
        195                 200                 205             


Asp Glu Lys Phe Lys Gly Lys Ala Thr Leu Thr Ser Asp Thr Ser Thr 
    210                 215                 220                 


Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala 
225                 230                 235                 240 


Val Tyr Tyr Cys Ala Arg Glu Lys Asp Asn Tyr Ala Thr Gly Ala Trp 
                245                 250                 255     


Phe Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Thr Thr 
            260                 265                 270         


Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln 
        275                 280                 285             


Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala 
    290                 295                 300                 


Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala 
305                 310                 315                 320 


Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr 
                325                 330                 335     


Leu Tyr Cys Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr 
            340                 345                 350         


Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg 
        355                 360                 365             


Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met 
    370                 375                 380                 


Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu 
385                 390                 395                 400 


Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys 
                405                 410                 415     


Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu 
            420                 425                 430         


Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu 
        435                 440                 445             


Pro Pro Arg Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala 
    450                 455                 460                 


Gly Asp Val Glu Glu Asn Pro Gly Pro Met Ala Leu Pro Val Thr Ala 
465                 470                 475                 480 


Leu Leu Leu Pro Leu Ala Leu Leu Leu His Ala Ala Arg Pro Asp Ile 
                485                 490                 495     


Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly Asp Arg 
            500                 505                 510         


Val Thr Ile Thr Cys Ser Ala Ser Ser Ser Ile Ser Tyr Met His Trp 
        515                 520                 525             


Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Thr Thr 
    530                 535                 540                 


Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser 
545                 550                 555                 560 


Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Asp Asp Phe 
                565                 570                 575     


Ala Thr Tyr Tyr Cys His Gln Arg Ser Thr Tyr Pro Leu Thr Phe Gly 
            580                 585                 590         


Gln Gly Thr Lys Val Glu Val Lys Gly Gly Gly Gly Ser Gly Gly Gly 
        595                 600                 605             


Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Val Gln Ser Gly Ala 
    610                 615                 620                 


Glu Val Lys Lys Pro Gly Ser Ser Val Lys Val Ser Cys Lys Ala Ser 
625                 630                 635                 640 


Gly Tyr Thr Phe Thr Ser Tyr Arg Met His Trp Val Arg Gln Ala Pro 
                645                 650                 655     


Gly Gln Gly Leu Glu Trp Ile Gly Tyr Ile Asn Pro Ser Thr Gly Tyr 
            660                 665                 670         


Thr Glu Tyr Asn Gln Lys Phe Lys Asp Lys Ala Thr Ile Thr Ala Asp 
        675                 680                 685             


Glu Ser Thr Asn Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu 
    690                 695                 700                 


Asp Thr Ala Val Tyr Tyr Cys Ala Arg Gly Gly Gly Val Phe Asp Tyr 
705                 710                 715                 720 


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Thr Thr Thr Pro Ala 
                725                 730                 735     


Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser 
            740                 745                 750         


Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr 
        755                 760                 765             


Arg Gly Leu Asp Phe Ala Cys Asp Phe Trp Val Leu Val Val Val Gly 
    770                 775                 780                 


Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile 
785                 790                 795                 800 


Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met 
                805                 810                 815     


Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro 
            820                 825                 830         


Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser 
        835                 840                 


<210>  95
<211>  2149
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  95
gcgatcgcat ggccttacca gtgaccgcct tgctcctgcc gctggccttg ctgctccacg       60

ccgccaggcc ggacatcgtg atgacccaaa gccccgacag cctggccgtg agcctgggcg      120

agagggtgac catgaactgc aaaagcagcc agtccctgct gtactccacc aaccagaaga      180

actacctggc ttggtatcaa cagaagcccg gacagagccc caagctgctg atctattggg      240

ccagcactag ggaaagcggc gtgcccgata ggttcagcgg cagcgggagc ggcacagact      300

tcactctgac cattagcagc gtgcaggctg aggatgtggc cgtctactac tgccagcagt      360

actacagcta caggaccttt gggggcggaa ctaagctgga gatcaaggga ggggggggat      420

ccgggggagg aggctccggc ggaggcggaa gccaagtgca actgcagcag agcggcccag      480

aggtggtcaa acctggggca agcgtgaaga tgagctgcaa ggctagcggc tataccttca      540

ccagctatgt gatccactgg gtgaggcaga aaccaggaca gggcctggac tggatcggct      600

acatcaaccc ctacaatgac ggcaccgatt atgacgaaaa attcaagggg aaggccaccc      660

tgaccagcga caccagcaca agcaccgcct acatggagct gtccagcctg aggtccgagg      720

acaccgccgt gtattactgt gccagggaga aggacaatta cgccaccggc gcttggttcg      780

cctactgggg ccagggcaca ctggtgacag tgagcagcac cacgacgcca gcgccgcgac      840

caccaacacc ggcgcccacc atcgcgtcgc agcccctgtc cctgcgccca gaggcgtgcc      900

ggccagcggc ggggggcgca gtgcacacga gggggctgga cttcgcctgt gatatctaca      960

tctgggcgcc cttggccggg acttgtgggg tccttctcct gtcactggtt atcacccttt     1020

actgcaggag taagaggagc aggctcctgc acagtgacta catgaacatg actccccgcc     1080

gccccgggcc cacccgcaag cattaccagc cctatgcccc accacgcgac ttcgcagcct     1140

atcgctccaa acggggcaga aagaaactcc tgtatatatt caaacaacca tttatgagac     1200

cagtacaaac tactcaagag gaagatggct gtagctgccg atttccagaa gaagaagaag     1260

gaggatgtga actgagagtg aagttcagca ggagcgcaga cgcccccgcg taccagcagg     1320

gccagaacca gctctataac gagctcaatc taggacgaag agaggagtac gatgttttgg     1380

acaagagacg tggccgggac cctgagatgg ggggaaagcc gcagagaagg aagaaccctc     1440

aggaaggcct gtacaatgaa ctgcagaaag ataagatggc ggaggcctac agtgagattg     1500

ggatgaaagg cgagcgccgg aggggcaagg ggcacgatgg cctttaccag ggtctcagta     1560

cagccaccaa ggacacctac gacgcccttc acatgcaggc cctgccccct cgcggaagcg     1620

gagccaccaa cttcagcctg ctgaagcagg ccggcgacgt ggaggagaac cccggcccca     1680

tgtacagaat gcagctgctg agctgcatcg ccctgagcct ggccctggtg accaacagcg     1740

gcatccacgt gttcatcctg ggctgcttca gcgccggcct gcccaagacc gaggccaact     1800

gggtgaacgt gatcagcgac ctgaagaaga tcgaggacct gatccagagc atgcacatcg     1860

acgccaccct gtacaccgag agcgacgtgc accccagctg caaggtgacc gccatgaagt     1920

gcttcctgct ggagctgcag gtgatcagcc tggagagcgg cgacgccagc atccacgaca     1980

ccgtggagaa cctgatcatc ctggccaaca acagcctgag cagcaacggc aacgtgaccg     2040

agagcggctg caaggagtgc gaggagctgg aggagaagaa catcaaggag ttcctgcaga     2100

gcttcgtgca catcgtgcag atgttcatca acaccagcta agtttaaac                 2149


<210>  96
<211>  710
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  96

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu 
            20                  25                  30          


Ala Val Ser Leu Gly Glu Arg Val Thr Met Asn Cys Lys Ser Ser Gln 
        35                  40                  45              


Ser Leu Leu Tyr Ser Thr Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln 
    50                  55                  60                  


Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr 
65                  70                  75                  80  


Arg Glu Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr 
                85                  90                  95      


Asp Phe Thr Leu Thr Ile Ser Ser Val Gln Ala Glu Asp Val Ala Val 
            100                 105                 110         


Tyr Tyr Cys Gln Gln Tyr Tyr Ser Tyr Arg Thr Phe Gly Gly Gly Thr 
        115                 120                 125             


Lys Leu Glu Ile Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Val Val 
145                 150                 155                 160 


Lys Pro Gly Ala Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr 
                165                 170                 175     


Phe Thr Ser Tyr Val Ile His Trp Val Arg Gln Lys Pro Gly Gln Gly 
            180                 185                 190         


Leu Asp Trp Ile Gly Tyr Ile Asn Pro Tyr Asn Asp Gly Thr Asp Tyr 
        195                 200                 205             


Asp Glu Lys Phe Lys Gly Lys Ala Thr Leu Thr Ser Asp Thr Ser Thr 
    210                 215                 220                 


Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala 
225                 230                 235                 240 


Val Tyr Tyr Cys Ala Arg Glu Lys Asp Asn Tyr Ala Thr Gly Ala Trp 
                245                 250                 255     


Phe Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Thr Thr 
            260                 265                 270         


Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln 
        275                 280                 285             


Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala 
    290                 295                 300                 


Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala 
305                 310                 315                 320 


Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr 
                325                 330                 335     


Leu Tyr Cys Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met 
            340                 345                 350         


Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro 
        355                 360                 365             


Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Lys Arg Gly Arg 
    370                 375                 380                 


Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln 
385                 390                 395                 400 


Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu 
                405                 410                 415     


Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala 
            420                 425                 430         


Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu 
        435                 440                 445             


Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp 
    450                 455                 460                 


Pro Glu Met Gly Gly Lys Pro Gln Arg Arg Lys Asn Pro Gln Glu Gly 
465                 470                 475                 480 


Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu 
                485                 490                 495     


Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu 
            500                 505                 510         


Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His 
        515                 520                 525             


Met Gln Ala Leu Pro Pro Arg Gly Ser Gly Ala Thr Asn Phe Ser Leu 
    530                 535                 540                 


Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met Tyr Arg 
545                 550                 555                 560 


Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu Val Thr Asn 
                565                 570                 575     


Ser Gly Ile His Val Phe Ile Leu Gly Cys Phe Ser Ala Gly Leu Pro 
            580                 585                 590         


Lys Thr Glu Ala Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys Ile 
        595                 600                 605             


Glu Asp Leu Ile Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr Glu 
    610                 615                 620                 


Ser Asp Val His Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe Leu 
625                 630                 635                 640 


Leu Glu Leu Gln Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile His 
                645                 650                 655     


Asp Thr Val Glu Asn Leu Ile Ile Leu Ala Asn Asn Ser Leu Ser Ser 
            660                 665                 670         


Asn Gly Asn Val Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu 
        675                 680                 685             


Glu Lys Asn Ile Lys Glu Phe Leu Gln Ser Phe Val His Ile Val Gln 
    690                 695                 700                 


Met Phe Ile Asn Thr Ser 
705                 710 


<210>  97
<211>  2623
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  97
gcgatcgcat ggccttacca gtgaccgcct tgctcctgcc gctggccttg ctgctccacg       60

ccgccaggcc ggacatcgtg atgacccaaa gccccgacag cctggccgtg agcctgggcg      120

agagggtgac catgaactgc aaaagcagcc agtccctgct gtactccacc aaccagaaga      180

actacctggc ttggtatcaa cagaagcccg gacagagccc caagctgctg atctattggg      240

ccagcactag ggaaagcggc gtgcccgata ggttcagcgg cagcgggagc ggcacagact      300

tcactctgac cattagcagc gtgcaggctg aggatgtggc cgtctactac tgccagcagt      360

actacagcta caggaccttt gggggcggaa ctaagctgga gatcaaggga ggggggggat      420

ccgggggagg aggctccggc ggaggcggaa gccaagtgca actgcagcag agcggcccag      480

aggtggtcaa acctggggca agcgtgaaga tgagctgcaa ggctagcggc tataccttca      540

ccagctatgt gatccactgg gtgaggcaga aaccaggaca gggcctggac tggatcggct      600

acatcaaccc ctacaatgac ggcaccgatt atgacgaaaa attcaagggg aaggccaccc      660

tgaccagcga caccagcaca agcaccgcct acatggagct gtccagcctg aggtccgagg      720

acaccgccgt gtattactgt gccagggaga aggacaatta cgccaccggc gcttggttcg      780

cctactgggg ccagggcaca ctggtgacag tgagcagcac cacgacgcca gcgccgcgac      840

caccaacacc ggcgcccacc atcgcgtcgc agcccctgtc cctgcgccca gaggcgtgcc      900

ggccagcggc ggggggcgca gtgcacacga gggggctgga cttcgcctgt gatatctaca      960

tctgggcgcc cttggccggg acttgtgggg tccttctcct gtcactggtt atcacccttt     1020

actgcaggag taagaggagc aggctcctgc acagtgacta catgaacatg actccccgcc     1080

gccccgggcc cacccgcaag cattaccagc cctatgcccc accacgcgac ttcgcagcct     1140

atcgctccaa acggggcaga aagaaactcc tgtatatatt caaacaacca tttatgagac     1200

cagtacaaac tactcaagag gaagatggct gtagctgccg atttccagaa gaagaagaag     1260

gaggatgtga actgagagtg aagttcagca ggagcgcaga cgcccccgcg taccagcagg     1320

gccagaacca gctctataac gagctcaatc taggacgaag agaggagtac gatgttttgg     1380

acaagagacg tggccgggac cctgagatgg ggggaaagcc gcagagaagg aagaaccctc     1440

aggaaggcct gtacaatgaa ctgcagaaag ataagatggc ggaggcctac agtgagattg     1500

ggatgaaagg cgagcgccgg aggggcaagg ggcacgatgg cctttaccag ggtctcagta     1560

cagccaccaa ggacacctac gacgcccttc acatgcaggc cctgccccct cgcggaagcg     1620

gagccaccaa cttcagcctg ctgaagcagg ccggcgacgt ggaggagaac cccggcccca     1680

tgtacagaat gcagctgctg agctgcatcg ccctgagcct ggccctggtg accaacagcg     1740

gcatccacgt gttcatcctg ggctgcttca gcgccggcct gcccaagacc gaggccaact     1800

gggtgaacgt gatcagcgac ctgaagaaga tcgaggacct gatccagagc atgcacatcg     1860

acgccaccct gtacaccgag agcgacgtgc accccagctg caaggtgacc gccatgaagt     1920

gcttcctgct ggagctgcag gtgatcagcc tggagagcgg cgacgccagc atccacgaca     1980

ccgtggagaa cctgatcatc ctggccaaca acagcctgag cagcaacggc aacgtgaccg     2040

agagcggctg caaggagtgc gaggagctgg aggagaagaa catcaaggag ttcctgcaga     2100

gcttcgtgca catcgtgcag atgttcatca acaccagctc cggcggcggc tccggcggcg     2160

gcggctccgg cggcggcggc tccggcggcg gcggctccgg cggcggctcc ctgcagatca     2220

cctgcccccc ccccatgagc gtggagcacg ccgacatctg ggtgaagagc tacagcctgt     2280

acagcagaga gagatacatc tgcaacagcg gcttcaagag aaaggccggc accagcagcc     2340

tgaccgagtg cgtgctgaac aaggccacca acgtggccca ctggaccacc cccagcctga     2400

agtgcatcag aaccaccacc cccgccccca ggccccccac ccccgccccc accatcgcca     2460

gccagcccct gagcctgagg cccgaggcct gcaggcccgc cgccggcggc gccgtgcaca     2520

ccaggggcct ggacttcgcc tgcgacgtgg ctatctccac gtccactgtc ctgctgtgtg     2580

ggctgagcgc tgtgtctctc ctggcatgct actaagttta aac                       2623


<210>  98
<211>  868
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  98

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu 
            20                  25                  30          


Ala Val Ser Leu Gly Glu Arg Val Thr Met Asn Cys Lys Ser Ser Gln 
        35                  40                  45              


Ser Leu Leu Tyr Ser Thr Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln 
    50                  55                  60                  


Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr 
65                  70                  75                  80  


Arg Glu Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr 
                85                  90                  95      


Asp Phe Thr Leu Thr Ile Ser Ser Val Gln Ala Glu Asp Val Ala Val 
            100                 105                 110         


Tyr Tyr Cys Gln Gln Tyr Tyr Ser Tyr Arg Thr Phe Gly Gly Gly Thr 
        115                 120                 125             


Lys Leu Glu Ile Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Val Val 
145                 150                 155                 160 


Lys Pro Gly Ala Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr 
                165                 170                 175     


Phe Thr Ser Tyr Val Ile His Trp Val Arg Gln Lys Pro Gly Gln Gly 
            180                 185                 190         


Leu Asp Trp Ile Gly Tyr Ile Asn Pro Tyr Asn Asp Gly Thr Asp Tyr 
        195                 200                 205             


Asp Glu Lys Phe Lys Gly Lys Ala Thr Leu Thr Ser Asp Thr Ser Thr 
    210                 215                 220                 


Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala 
225                 230                 235                 240 


Val Tyr Tyr Cys Ala Arg Glu Lys Asp Asn Tyr Ala Thr Gly Ala Trp 
                245                 250                 255     


Phe Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Thr Thr 
            260                 265                 270         


Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln 
        275                 280                 285             


Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala 
    290                 295                 300                 


Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala 
305                 310                 315                 320 


Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr 
                325                 330                 335     


Leu Tyr Cys Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met 
            340                 345                 350         


Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro 
        355                 360                 365             


Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Lys Arg Gly Arg 
    370                 375                 380                 


Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln 
385                 390                 395                 400 


Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu 
                405                 410                 415     


Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala 
            420                 425                 430         


Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu 
        435                 440                 445             


Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp 
    450                 455                 460                 


Pro Glu Met Gly Gly Lys Pro Gln Arg Arg Lys Asn Pro Gln Glu Gly 
465                 470                 475                 480 


Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu 
                485                 490                 495     


Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu 
            500                 505                 510         


Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His 
        515                 520                 525             


Met Gln Ala Leu Pro Pro Arg Gly Ser Gly Ala Thr Asn Phe Ser Leu 
    530                 535                 540                 


Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met Tyr Arg 
545                 550                 555                 560 


Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu Val Thr Asn 
                565                 570                 575     


Ser Gly Ile His Val Phe Ile Leu Gly Cys Phe Ser Ala Gly Leu Pro 
            580                 585                 590         


Lys Thr Glu Ala Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys Ile 
        595                 600                 605             


Glu Asp Leu Ile Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr Glu 
    610                 615                 620                 


Ser Asp Val His Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe Leu 
625                 630                 635                 640 


Leu Glu Leu Gln Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile His 
                645                 650                 655     


Asp Thr Val Glu Asn Leu Ile Ile Leu Ala Asn Asn Ser Leu Ser Ser 
            660                 665                 670         


Asn Gly Asn Val Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu 
        675                 680                 685             


Glu Lys Asn Ile Lys Glu Phe Leu Gln Ser Phe Val His Ile Val Gln 
    690                 695                 700                 


Met Phe Ile Asn Thr Ser Ser Gly Gly Gly Ser Gly Gly Gly Gly Ser 
705                 710                 715                 720 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Leu Gln 
                725                 730                 735     


Ile Thr Cys Pro Pro Pro Met Ser Val Glu His Ala Asp Ile Trp Val 
            740                 745                 750         


Lys Ser Tyr Ser Leu Tyr Ser Arg Glu Arg Tyr Ile Cys Asn Ser Gly 
        755                 760                 765             


Phe Lys Arg Lys Ala Gly Thr Ser Ser Leu Thr Glu Cys Val Leu Asn 
    770                 775                 780                 


Lys Ala Thr Asn Val Ala His Trp Thr Thr Pro Ser Leu Lys Cys Ile 
785                 790                 795                 800 


Arg Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile 
                805                 810                 815     


Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala 
            820                 825                 830         


Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Val Ala 
        835                 840                 845             


Ile Ser Thr Ser Thr Val Leu Leu Cys Gly Leu Ser Ala Val Ser Leu 
    850                 855                 860                 


Leu Ala Cys Tyr 
865             


<210>  99
<211>  2389
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  99
gcgatcgcac catggcctta ccagtgaccg ccttgctcct gccgctggcc ttgctgctcc       60

acgccgccag gccggacatc gtgatgagcc agagccccag cagcctggcc gtgagcgtgg      120

gcgagaagtt caccgtgaac tgcaagagca gccagagcct gctgtacagc agcaaccaga      180

agaacttcct ggcctggtac cagcagaagc ccggccagag ccccaagctg ctgatctact      240

gggccagcac cagagagagc ggcgtgcccg acagattcat cggcagcggc agcggcaccg      300

acttcaccct gaccatcagc agcgtgaagg ccgaggacct ggccgtgtac tactgccagc      360

agcactacag atacccctgg accttcggcg gcggcaccaa gctggagatc aagagagcca      420

gaggaggggg gggatccggg ggaggaggct ccggcggagg cggaagccag gtgaccctga      480

aggagagcgg ccccggcatc ctgcagccca gccagaccct gagcctgacc tgcagcttca      540

gcggcttcag cctgaacacc agcggcgtgg gcgtgggctg gatcagacag cccagcggca      600

agggcctgga gtggctggcc cacatctggt gggacgacga cgagagatac aaccccgtgc      660

tgaagagcag actgaccatc agcaaggaca ccagcagcaa ccaggtgttc ctgaagatcg      720

ccaacgtgga caccgccgac agcgccacct actactgcgt gagaagcatg gtggcctggt      780

tcttccccta ctggggcaga ggcaccctgg tgaccgtgag cgccaccacg acgccagcgc      840

cgcgaccacc aacaccggcg cccaccatcg cgtcgcagcc cctgtccctg cgcccagagg      900

cgtgccggcc agcggcgggg ggcgcagtgc acacgagggg gctggacttc gcctgtgata      960

tctacatctg ggcgcccttg gccgggactt gtggggtcct tctcctgtca ctggttatca     1020

ccctttactg caggagtaag aggagcaggc tcctgcacag tgactacatg aacatgactc     1080

cccgccgccc cgggcccacc cgcaagcatt accagcccta tgccccacca cgcgacttcg     1140

cagcctatcg ctccagggtg aagttcagca ggagcgccga cgcccccgcc taccagcagg     1200

gccagaacca gctgtacaac gagctgaacc tgggcaggag ggaggagtac gacgtgctgg     1260

acaagaggag gggcagggac cccgagatgg gcggcaagcc ccagaggagg aagaaccccc     1320

aggagggcct gtacaacgag ctgcagaagg acaagatggc cgaggcctac agcgagatcg     1380

gcatgaaggg cgagaggagg aggggcaagg gccacgacgg cctgtaccag ggcctgagca     1440

ccgccaccaa ggacacctac gacgccctgc acatgcaggc cctgcccccc aggggaagcg     1500

gagccaccaa cttcagcctg ctgaagcagg ccggcgacgt ggaggagaac cccggcccca     1560

tgtacagaat gcagctgctg agctgcatcg ccctgagcct ggccctggtg accaacagcg     1620

gcatccacgt gttcatcctg ggctgcttca gcgccggcct gcccaagacc gaggccaact     1680

gggtgaacgt gatcagcgac ctgaagaaga tcgaggacct gatccagagc atgcacatcg     1740

acgccaccct gtacaccgag agcgacgtgc accccagctg caaggtgacc gccatgaagt     1800

gcttcctgct ggagctgcag gtgatcagcc tggagagcgg cgacgccagc atccacgaca     1860

ccgtggagaa cctgatcatc ctggccaaca acagcctgag cagcaacggc aacgtgaccg     1920

agagcggctg caaggagtgc gaggagctgg aggagaagaa catcaaggag ttcctgcaga     1980

gcttcgtgca catcgtgcag atgttcatca acaccagctc cggcggcggc tccggcggcg     2040

gcggctccgg cggcggcggc tccggcggcg gcggctccgg cggcggctcc ctgcaggccc     2100

ccagaagagc cagaggctgc agaaccctgg gcctgcccgc cctgctgctg ctgctgctgc     2160

tgagaccccc cgccaccaga ggcatcacct gccccccccc catgagcgtg gagcacgccg     2220

acatctgggt gaagagctac agcctgtaca gcagagagag atacatctgc aacagcggct     2280

tcaagagaaa ggccggcacc agcagcctga ccgagtgcgt gctgaacaag gccaccaacg     2340

tggcccactg gaccaccccc agcctgaagt gcatcagata agtttaaac                 2389


<210>  100
<211>  789
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  100

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Asp Ile Val Met Ser Gln Ser Pro Ser Ser Leu 
            20                  25                  30          


Ala Val Ser Val Gly Glu Lys Phe Thr Val Asn Cys Lys Ser Ser Gln 
        35                  40                  45              


Ser Leu Leu Tyr Ser Ser Asn Gln Lys Asn Phe Leu Ala Trp Tyr Gln 
    50                  55                  60                  


Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr 
65                  70                  75                  80  


Arg Glu Ser Gly Val Pro Asp Arg Phe Ile Gly Ser Gly Ser Gly Thr 
                85                  90                  95      


Asp Phe Thr Leu Thr Ile Ser Ser Val Lys Ala Glu Asp Leu Ala Val 
            100                 105                 110         


Tyr Tyr Cys Gln Gln His Tyr Arg Tyr Pro Trp Thr Phe Gly Gly Gly 
        115                 120                 125             


Thr Lys Leu Glu Ile Lys Arg Ala Arg Gly Gly Gly Gly Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Thr Leu Lys Glu Ser Gly 
145                 150                 155                 160 


Pro Gly Ile Leu Gln Pro Ser Gln Thr Leu Ser Leu Thr Cys Ser Phe 
                165                 170                 175     


Ser Gly Phe Ser Leu Asn Thr Ser Gly Val Gly Val Gly Trp Ile Arg 
            180                 185                 190         


Gln Pro Ser Gly Lys Gly Leu Glu Trp Leu Ala His Ile Trp Trp Asp 
        195                 200                 205             


Asp Asp Glu Arg Tyr Asn Pro Val Leu Lys Ser Arg Leu Thr Ile Ser 
    210                 215                 220                 


Lys Asp Thr Ser Ser Asn Gln Val Phe Leu Lys Ile Ala Asn Val Asp 
225                 230                 235                 240 


Thr Ala Asp Ser Ala Thr Tyr Tyr Cys Val Arg Ser Met Val Ala Trp 
                245                 250                 255     


Phe Phe Pro Tyr Trp Gly Arg Gly Thr Leu Val Thr Val Ser Ala Thr 
            260                 265                 270         


Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser 
        275                 280                 285             


Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly 
    290                 295                 300                 


Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp 
305                 310                 315                 320 


Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile 
                325                 330                 335     


Thr Leu Tyr Cys Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr 
            340                 345                 350         


Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln 
        355                 360                 365             


Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Arg Val Lys 
    370                 375                 380                 


Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln 
385                 390                 395                 400 


Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu 
                405                 410                 415     


Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Gln Arg 
            420                 425                 430         


Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys 
        435                 440                 445             


Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg 
    450                 455                 460                 


Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys 
465                 470                 475                 480 


Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg Gly Ser 
                485                 490                 495     


Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu 
            500                 505                 510         


Asn Pro Gly Pro Met Tyr Arg Met Gln Leu Leu Ser Cys Ile Ala Leu 
        515                 520                 525             


Ser Leu Ala Leu Val Thr Asn Ser Gly Ile His Val Phe Ile Leu Gly 
    530                 535                 540                 


Cys Phe Ser Ala Gly Leu Pro Lys Thr Glu Ala Asn Trp Val Asn Val 
545                 550                 555                 560 


Ile Ser Asp Leu Lys Lys Ile Glu Asp Leu Ile Gln Ser Met His Ile 
                565                 570                 575     


Asp Ala Thr Leu Tyr Thr Glu Ser Asp Val His Pro Ser Cys Lys Val 
            580                 585                 590         


Thr Ala Met Lys Cys Phe Leu Leu Glu Leu Gln Val Ile Ser Leu Glu 
        595                 600                 605             


Ser Gly Asp Ala Ser Ile His Asp Thr Val Glu Asn Leu Ile Ile Leu 
    610                 615                 620                 


Ala Asn Asn Ser Leu Ser Ser Asn Gly Asn Val Thr Glu Ser Gly Cys 
625                 630                 635                 640 


Lys Glu Cys Glu Glu Leu Glu Glu Lys Asn Ile Lys Glu Phe Leu Gln 
                645                 650                 655     


Ser Phe Val His Ile Val Gln Met Phe Ile Asn Thr Ser Ser Gly Gly 
            660                 665                 670         


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        675                 680                 685             


Ser Gly Gly Gly Ser Leu Gln Ala Pro Arg Arg Ala Arg Gly Cys Arg 
    690                 695                 700                 


Thr Leu Gly Leu Pro Ala Leu Leu Leu Leu Leu Leu Leu Arg Pro Pro 
705                 710                 715                 720 


Ala Thr Arg Gly Ile Thr Cys Pro Pro Pro Met Ser Val Glu His Ala 
                725                 730                 735     


Asp Ile Trp Val Lys Ser Tyr Ser Leu Tyr Ser Arg Glu Arg Tyr Ile 
            740                 745                 750         


Cys Asn Ser Gly Phe Lys Arg Lys Ala Gly Thr Ser Ser Leu Thr Glu 
        755                 760                 765             


Cys Val Leu Asn Lys Ala Thr Asn Val Ala His Trp Thr Thr Pro Ser 
    770                 775                 780                 


Leu Lys Cys Ile Arg 
785                 


<210>  101
<211>  2371
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  101
gcgatcgcac catggcctta ccagtgaccg ccttgctcct gccgctggcc ttgctgctcc       60

acgccgccag gccggacatt atgatgacac agtcgccatc atctctggct gtgtctgcag      120

gagaaaaggt cactatgacc tgtaagtcca gtcaaagtgt tttatacagt tcaaatcaga      180

agaactactt ggcctggtac cagcagaaac cagggcagtc tcctaaacta ctgatctact      240

gggcatccac tagggaatct ggtgtccctg atcgcttcac aggcagtgga tctgggacag      300

attttactct taccatcagc agtgtgcaac ctgaagacct ggcagtttat tactgtcatc      360

aatacctctc ctcgcacacg ttcggagggg ggaccaagct ggaaataaaa cggggtggcg      420

gtggctcggg cggtggtggg tcgggtggcg gcggatctca actgcagcag cctggggctg      480

agctggtgag gcctgggtct tcagtgaagc tgtcctgcaa ggcttctggc tacaccttca      540

ccaggtactg gatacattgg gtgaagcaga ggcctataca aggccttgaa tggattggta      600

acattgatcc ttctgatagt gaaactcact acaatcaaaa gttcaaggac aaggccacat      660

tgactgtaga caaatcctcc ggcacagcct acatgcagct cagcagcctg acatctgagg      720

actctgcggt ctattactgt gcaacagagg atctttacta tgctatggag tactggggtc      780

aaggaacctc agtcaccgtc tcctctacca cgacgccagc gccgcgacca ccaacaccgg      840

cgcccaccat cgcgtcgcag cccctgtccc tgcgcccaga ggcgtgccgg ccagcggcgg      900

ggggcgcagt gcacacgagg gggctggact tcgcctgtga tatctacatc tgggcgccct      960

tggccgggac ttgtggggtc cttctcctgt cactggttat caccctttac tgcaggagta     1020

agaggagcag gctcctgcac agtgactaca tgaacatgac tccccgccgc cccgggccca     1080

cccgcaagca ttaccagccc tatgccccac cacgcgactt cgcagcctat cgctccagag     1140

tgaagttcag caggagcgca gacgcccccg cgtaccagca gggccagaac cagctctata     1200

acgagctcaa tctaggacga agagaggagt acgatgtttt ggacaagaga cgtggccggg     1260

accctgagat ggggggaaag ccgcagagaa ggaagaaccc tcaggaaggc ctgtacaatg     1320

aactgcagaa agataagatg gcggaggcct acagtgagat tgggatgaaa ggcgagcgcc     1380

ggaggggcaa ggggcacgat ggcctttacc agggtctcag tacagccacc aaggacacct     1440

acgacgccct tcacatgcag gccctgcccc ctcgcggaag cggagccacc aacttcagcc     1500

tgctgaagca ggccggcgac gtggaggaga accccggccc catgtacaga atgcagctgc     1560

tgagctgcat cgccctgagc ctggccctgg tgaccaacag cggcatccac gtgttcatcc     1620

tgggctgctt cagcgccggc ctgcccaaga ccgaggccaa ctgggtgaac gtgatcagcg     1680

acctgaagaa gatcgaggac ctgatccaga gcatgcacat cgacgccacc ctgtacaccg     1740

agagcgacgt gcaccccagc tgcaaggtga ccgccatgaa gtgcttcctg ctggagctgc     1800

aggtgatcag cctggagagc ggcgacgcca gcatccacga caccgtggag aacctgatca     1860

tcctggccaa caacagcctg agcagcaacg gcaacgtgac cgagagcggc tgcaaggagt     1920

gcgaggagct ggaggagaag aacatcaagg agttcctgca gagcttcgtg cacatcgtgc     1980

agatgttcat caacaccagc tccggcggcg gctccggcgg cggcggctcc ggcggcggcg     2040

gctccggcgg cggcggctcc ggcggcggct ccctgcaggc ccccagaaga gccagaggct     2100

gcagaaccct gggcctgccc gccctgctgc tgctgctgct gctgagaccc cccgccacca     2160

gaggcatcac ctgccccccc cccatgagcg tggagcacgc cgacatctgg gtgaagagct     2220

acagcctgta cagcagagag agatacatct gcaacagcgg cttcaagaga aaggccggca     2280

ccagcagcct gaccgagtgc gtgctgaaca aggccaccaa cgtggcccac tggaccaccc     2340

ccagcctgaa gtgcatcaga taagtttaaa c                                    2371


<210>  102
<211>  783
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  102

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Asp Ile Met Met Thr Gln Ser Pro Ser Ser Leu 
            20                  25                  30          


Ala Val Ser Ala Gly Glu Lys Val Thr Met Thr Cys Lys Ser Ser Gln 
        35                  40                  45              


Ser Val Leu Tyr Ser Ser Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln 
    50                  55                  60                  


Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr 
65                  70                  75                  80  


Arg Glu Ser Gly Val Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr 
                85                  90                  95      


Asp Phe Thr Leu Thr Ile Ser Ser Val Gln Pro Glu Asp Leu Ala Val 
            100                 105                 110         


Tyr Tyr Cys His Gln Tyr Leu Ser Ser His Thr Phe Gly Gly Gly Thr 
        115                 120                 125             


Lys Leu Glu Ile Lys Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Arg 
145                 150                 155                 160 


Pro Gly Ser Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
                165                 170                 175     


Thr Arg Tyr Trp Ile His Trp Val Lys Gln Arg Pro Ile Gln Gly Leu 
            180                 185                 190         


Glu Trp Ile Gly Asn Ile Asp Pro Ser Asp Ser Glu Thr His Tyr Asn 
        195                 200                 205             


Gln Lys Phe Lys Asp Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Gly 
    210                 215                 220                 


Thr Ala Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val 
225                 230                 235                 240 


Tyr Tyr Cys Ala Thr Glu Asp Leu Tyr Tyr Ala Met Glu Tyr Trp Gly 
                245                 250                 255     


Gln Gly Thr Ser Val Thr Val Ser Ser Thr Thr Thr Pro Ala Pro Arg 
            260                 265                 270         


Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg 
        275                 280                 285             


Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly 
    290                 295                 300                 


Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr 
305                 310                 315                 320 


Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Arg Ser 
                325                 330                 335     


Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg 
            340                 345                 350         


Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg 
        355                 360                 365             


Asp Phe Ala Ala Tyr Arg Ser Arg Val Lys Phe Ser Arg Ser Ala Asp 
    370                 375                 380                 


Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn 
385                 390                 395                 400 


Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg 
                405                 410                 415     


Asp Pro Glu Met Gly Gly Lys Pro Gln Arg Arg Lys Asn Pro Gln Glu 
            420                 425                 430         


Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser 
        435                 440                 445             


Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly 
    450                 455                 460                 


Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu 
465                 470                 475                 480 


His Met Gln Ala Leu Pro Pro Arg Gly Ser Gly Ala Thr Asn Phe Ser 
                485                 490                 495     


Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met Tyr 
            500                 505                 510         


Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu Val Thr 
        515                 520                 525             


Asn Ser Gly Ile His Val Phe Ile Leu Gly Cys Phe Ser Ala Gly Leu 
    530                 535                 540                 


Pro Lys Thr Glu Ala Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys 
545                 550                 555                 560 


Ile Glu Asp Leu Ile Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr 
                565                 570                 575     


Glu Ser Asp Val His Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe 
            580                 585                 590         


Leu Leu Glu Leu Gln Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile 
        595                 600                 605             


His Asp Thr Val Glu Asn Leu Ile Ile Leu Ala Asn Asn Ser Leu Ser 
    610                 615                 620                 


Ser Asn Gly Asn Val Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu 
625                 630                 635                 640 


Glu Glu Lys Asn Ile Lys Glu Phe Leu Gln Ser Phe Val His Ile Val 
                645                 650                 655     


Gln Met Phe Ile Asn Thr Ser Ser Gly Gly Gly Ser Gly Gly Gly Gly 
            660                 665                 670         


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Leu 
        675                 680                 685             


Gln Ala Pro Arg Arg Ala Arg Gly Cys Arg Thr Leu Gly Leu Pro Ala 
    690                 695                 700                 


Leu Leu Leu Leu Leu Leu Leu Arg Pro Pro Ala Thr Arg Gly Ile Thr 
705                 710                 715                 720 


Cys Pro Pro Pro Met Ser Val Glu His Ala Asp Ile Trp Val Lys Ser 
                725                 730                 735     


Tyr Ser Leu Tyr Ser Arg Glu Arg Tyr Ile Cys Asn Ser Gly Phe Lys 
            740                 745                 750         


Arg Lys Ala Gly Thr Ser Ser Leu Thr Glu Cys Val Leu Asn Lys Ala 
        755                 760                 765             


Thr Asn Val Ala His Trp Thr Thr Pro Ser Leu Lys Cys Ile Arg 
    770                 775                 780             


<210>  103
<211>  2356
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  103
gcgatcgcac catggcctta ccagtgaccg ccttgctcct gccgctggcc ttgctgctcc       60

acgccgccag gccggacatc cagatgaccc agagccccag cagcctgagc gccagcgtgg      120

gcgacagagt gaccatcacc tgcagcgcca gcagcagcgt gagctacatg aactggtacc      180

agcagacccc cggcaaggcc cccaagagat ggatctacga caccagcaag ctggccagcg      240

gcgtgcccag cagattcagc ggcagcggca gcggcaccga ctacaccttc accatcagca      300

gcctgcagcc cgaggacatc gccacctact actgccagca gtggagcagc aaccccttca      360

ccttcggcca gggcaccaag ctgcagatcg gcggcggcgg cagcggcggc ggcggcagcg      420

gcggcggcgg cagccaggtg cagctggtgc agagcggcgg cggcgtggtg cagcccggca      480

gaagcctgag actgagctgc aaggccagcg gctacacctt caccagatac accatgcact      540

gggtgagaca ggcccccggc aagggcctgg agtggatcgg ctacatcaac cccagcagag      600

gctacaccaa ctacaaccag aaggtgaagg acagattcac catcagcaga gacaacagca      660

agaacaccgc cttcctgcag atggacagcc tgagacccga ggacaccggc gtgtacttct      720

gcgccagata ctacgacgac cactactgcc tggactactg gggccagggc acccccgtga      780

ccgtgagcag caccacgacg ccagcgccgc gaccaccaac accggcgccc accatcgcgt      840

cgcagcccct gtccctgcgc ccagaggcgt gccggccagc ggcggggggc gcagtgcaca      900

cgagggggct ggacttcgcc tgtgatatct acatctgggc gcccttggcc gggacttgtg      960

gggtccttct cctgtcactg gttatcaccc tttactgcag gagtaagagg agcaggctcc     1020

tgcacagtga ctacatgaac atgactcccc gccgccccgg gcccacccgc aagcattacc     1080

agccctatgc cccaccacgc gacttcgcag cctatcgctc cagagtgaag ttcagcagga     1140

gcgcagacgc ccccgcgtac cagcagggcc agaaccagct ctataacgag ctcaatctag     1200

gacgaagaga ggagtacgat gttttggaca agagacgtgg ccgggaccct gagatggggg     1260

gaaagccgca gagaaggaag aaccctcagg aaggcctgta caatgaactg cagaaagata     1320

agatggcgga ggcctacagt gagattggga tgaaaggcga gcgccggagg ggcaaggggc     1380

acgatggcct ttaccagggt ctcagtacag ccaccaagga cacctacgac gcccttcaca     1440

tgcaggccct gccccctcgc ggaagcggag ccaccaactt cagcctgctg aagcaggccg     1500

gcgacgtgga ggagaacccc ggccccatgt acagaatgca gctgctgagc tgcatcgccc     1560

tgagcctggc cctggtgacc aacagcggca tccacgtgtt catcctgggc tgcttcagcg     1620

ccggcctgcc caagaccgag gccaactggg tgaacgtgat cagcgacctg aagaagatcg     1680

aggacctgat ccagagcatg cacatcgacg ccaccctgta caccgagagc gacgtgcacc     1740

ccagctgcaa ggtgaccgcc atgaagtgct tcctgctgga gctgcaggtg atcagcctgg     1800

agagcggcga cgccagcatc cacgacaccg tggagaacct gatcatcctg gccaacaaca     1860

gcctgagcag caacggcaac gtgaccgaga gcggctgcaa ggagtgcgag gagctggagg     1920

agaagaacat caaggagttc ctgcagagct tcgtgcacat cgtgcagatg ttcatcaaca     1980

ccagctccgg cggcggctcc ggcggcggcg gctccggcgg cggcggctcc ggcggcggcg     2040

gctccggcgg cggctccctg caggccccca gaagagccag aggctgcaga accctgggcc     2100

tgcccgccct gctgctgctg ctgctgctga gaccccccgc caccagaggc atcacctgcc     2160

ccccccccat gagcgtggag cacgccgaca tctgggtgaa gagctacagc ctgtacagca     2220

gagagagata catctgcaac agcggcttca agagaaaggc cggcaccagc agcctgaccg     2280

agtgcgtgct gaacaaggcc accaacgtgg cccactggac cacccccagc ctgaagtgca     2340

tcagataagt ttaaac                                                     2356


<210>  104
<211>  777
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  104

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu 
            20                  25                  30          


Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Ser Ala Ser Ser 
        35                  40                  45              


Ser Val Ser Tyr Met Asn Trp Tyr Gln Gln Thr Pro Gly Lys Ala Pro 
    50                  55                  60                  


Lys Arg Trp Ile Tyr Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Thr Phe Thr Ile Ser 
                85                  90                  95      


Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Trp Ser 
            100                 105                 110         


Ser Asn Pro Phe Thr Phe Gly Gln Gly Thr Lys Leu Gln Ile Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln 
    130                 135                 140                 


Leu Val Gln Ser Gly Gly Gly Val Val Gln Pro Gly Arg Ser Leu Arg 
145                 150                 155                 160 


Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Arg Tyr Thr Met His 
                165                 170                 175     


Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Gly Tyr Ile 
            180                 185                 190         


Asn Pro Ser Arg Gly Tyr Thr Asn Tyr Asn Gln Lys Val Lys Asp Arg 
        195                 200                 205             


Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Ala Phe Leu Gln Met 
    210                 215                 220                 


Asp Ser Leu Arg Pro Glu Asp Thr Gly Val Tyr Phe Cys Ala Arg Tyr 
225                 230                 235                 240 


Tyr Asp Asp His Tyr Cys Leu Asp Tyr Trp Gly Gln Gly Thr Pro Val 
                245                 250                 255     


Thr Val Ser Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala 
            260                 265                 270         


Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg 
        275                 280                 285             


Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys 
    290                 295                 300                 


Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu 
305                 310                 315                 320 


Leu Ser Leu Val Ile Thr Leu Tyr Cys Arg Ser Lys Arg Ser Arg Leu 
                325                 330                 335     


Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr 
            340                 345                 350         


Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr 
        355                 360                 365             


Arg Ser Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln 
    370                 375                 380                 


Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu 
385                 390                 395                 400 


Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly 
                405                 410                 415     


Gly Lys Pro Gln Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu 
            420                 425                 430         


Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys 
        435                 440                 445             


Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu 
    450                 455                 460                 


Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu 
465                 470                 475                 480 


Pro Pro Arg Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala 
                485                 490                 495     


Gly Asp Val Glu Glu Asn Pro Gly Pro Met Tyr Arg Met Gln Leu Leu 
            500                 505                 510         


Ser Cys Ile Ala Leu Ser Leu Ala Leu Val Thr Asn Ser Gly Ile His 
        515                 520                 525             


Val Phe Ile Leu Gly Cys Phe Ser Ala Gly Leu Pro Lys Thr Glu Ala 
    530                 535                 540                 


Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys Ile Glu Asp Leu Ile 
545                 550                 555                 560 


Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr Glu Ser Asp Val His 
                565                 570                 575     


Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe Leu Leu Glu Leu Gln 
            580                 585                 590         


Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile His Asp Thr Val Glu 
        595                 600                 605             


Asn Leu Ile Ile Leu Ala Asn Asn Ser Leu Ser Ser Asn Gly Asn Val 
    610                 615                 620                 


Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu Lys Asn Ile 
625                 630                 635                 640 


Lys Glu Phe Leu Gln Ser Phe Val His Ile Val Gln Met Phe Ile Asn 
                645                 650                 655     


Thr Ser Ser Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
            660                 665                 670         


Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Leu Gln Ala Pro Arg Arg 
        675                 680                 685             


Ala Arg Gly Cys Arg Thr Leu Gly Leu Pro Ala Leu Leu Leu Leu Leu 
    690                 695                 700                 


Leu Leu Arg Pro Pro Ala Thr Arg Gly Ile Thr Cys Pro Pro Pro Met 
705                 710                 715                 720 


Ser Val Glu His Ala Asp Ile Trp Val Lys Ser Tyr Ser Leu Tyr Ser 
                725                 730                 735     


Arg Glu Arg Tyr Ile Cys Asn Ser Gly Phe Lys Arg Lys Ala Gly Thr 
            740                 745                 750         


Ser Ser Leu Thr Glu Cys Val Leu Asn Lys Ala Thr Asn Val Ala His 
        755                 760                 765             


Trp Thr Thr Pro Ser Leu Lys Cys Ile 
    770                 775         


<210>  105
<211>  2401
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  105
gcgatcgcac catggcctta ccagtgaccg ccttgctcct gccgctggcc ttgctgctcc       60

acgccgccag gccgggcgcc cagcccgcca tggccgccta caaggacatc cagatgaccc      120

agaccaccag cagcctgagc gccagcctgg gcgacagagt gaccatcagc tgcagcgcca      180

gccagggcat cagcaactac ctgaactggt accagcagaa gcccgacggc accaacaagc      240

tgctgatcta ctacaccagc agcctgcaca gcggcgtgcc cagcagattc agcggcagcg      300

gcagcggcac cgactacagc ctgcacagca acctggagcc cgaggacatc gccacctact      360

actgccagca gtacagcaag ctgccctaca ccttcggcgg cggcaccaag ctggagatca      420

agagaggcgg cggcggcagc ggcggcggcg gcagcggcgg cggcggcagc ggcggcggcg      480

gcagcgaggt gcagctggtg gagagcggcg gcggcctggt gaagcccggc ggcagcctga      540

agctgagctg cgccgccagc ggcctgacct tcagcagcta cgccatgagc tggaacagac      600

agacccccga gaagagactg gagtgggtgg ccagcatcag cagcggcggc ttcacctact      660

accccgacag caacaagggc agattcacca tcagcagaga caacgccaga aacatcctgt      720

acctgcagat gagcagcctg agaagcgagg acaccgccat gtactactgc gccagagacg      780

aggtgagagg ctacctggac gtgtggggcg ccggcaccac cgtgaccgtg agcagcacca      840

cgacgccagc gccgcgacca ccaacaccgg cgcccaccat cgcgtcgcag cccctgtccc      900

tgcgcccaga ggcgtgccgg ccagcggcgg ggggcgcagt gcacacgagg gggctggact      960

tcgcctgtga tatctacatc tgggcgccct tggccgggac ttgtggggtc cttctcctgt     1020

cactggttat caccctttac tgcaggagta agaggagcag gctcctgcac agtgactaca     1080

tgaacatgac tccccgccgc cccgggccca cccgcaagca ttaccagccc tatgccccac     1140

cacgcgactt cgcagcctat cgctccagag tgaagttcag caggagcgca gacgcccccg     1200

cgtaccagca gggccagaac cagctctata acgagctcaa tctaggacga agagaggagt     1260

acgatgtttt ggacaagaga cgtggccggg accctgagat ggggggaaag ccgcagagaa     1320

ggaagaaccc tcaggaaggc ctgtacaatg aactgcagaa agataagatg gcggaggcct     1380

acagtgagat tgggatgaaa ggcgagcgcc ggaggggcaa ggggcacgat ggcctttacc     1440

agggtctcag tacagccacc aaggacacct acgacgccct tcacatgcag gccctgcccc     1500

ctcgcggaag cggagccacc aacttcagcc tgctgaagca ggccggcgac gtggaggaga     1560

accccggccc catgtacaga atgcagctgc tgagctgcat cgccctgagc ctggccctgg     1620

tgaccaacag cggcatccac gtgttcatcc tgggctgctt cagcgccggc ctgcccaaga     1680

ccgaggccaa ctgggtgaac gtgatcagcg acctgaagaa gatcgaggac ctgatccaga     1740

gcatgcacat cgacgccacc ctgtacaccg agagcgacgt gcaccccagc tgcaaggtga     1800

ccgccatgaa gtgcttcctg ctggagctgc aggtgatcag cctggagagc ggcgacgcca     1860

gcatccacga caccgtggag aacctgatca tcctggccaa caacagcctg agcagcaacg     1920

gcaacgtgac cgagagcggc tgcaaggagt gcgaggagct ggaggagaag aacatcaagg     1980

agttcctgca gagcttcgtg cacatcgtgc agatgttcat caacaccagc tccggcggcg     2040

gctccggcgg cggcggctcc ggcggcggcg gctccggcgg cggcggctcc ggcggcggct     2100

ccctgcaggc ccccagaaga gccagaggct gcagaaccct gggcctgccc gccctgctgc     2160

tgctgctgct gctgagaccc cccgccacca gaggcatcac ctgccccccc cccatgagcg     2220

tggagcacgc cgacatctgg gtgaagagct acagcctgta cagcagagag agatacatct     2280

gcaacagcgg cttcaagaga aaggccggca ccagcagcct gaccgagtgc gtgctgaaca     2340

aggccaccaa cgtggcccac tggaccaccc ccagcctgaa gtgcatcaga taagtttaaa     2400

c                                                                     2401


<210>  106
<211>  793
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  106

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gly Ala Gln Pro Ala Met Ala Ala Tyr Lys Asp 
            20                  25                  30          


Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly Asp 
        35                  40                  45              


Arg Val Thr Ile Ser Cys Ser Ala Ser Gln Gly Ile Ser Asn Tyr Leu 
    50                  55                  60                  


Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Asn Lys Leu Leu Ile Tyr 
65                  70                  75                  80  


Tyr Thr Ser Ser Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
                85                  90                  95      


Gly Ser Gly Thr Asp Tyr Ser Leu His Ser Asn Leu Glu Pro Glu Asp 
            100                 105                 110         


Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr Ser Lys Leu Pro Tyr Thr Phe 
        115                 120                 125             


Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Gly Gly Gly Gly Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val 
145                 150                 155                 160 


Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly Ser Leu 
                165                 170                 175     


Lys Leu Ser Cys Ala Ala Ser Gly Leu Thr Phe Ser Ser Tyr Ala Met 
            180                 185                 190         


Ser Trp Asn Arg Gln Thr Pro Glu Lys Arg Leu Glu Trp Val Ala Ser 
        195                 200                 205             


Ile Ser Ser Gly Gly Phe Thr Tyr Tyr Pro Asp Ser Asn Lys Gly Arg 
    210                 215                 220                 


Phe Thr Ile Ser Arg Asp Asn Ala Arg Asn Ile Leu Tyr Leu Gln Met 
225                 230                 235                 240 


Ser Ser Leu Arg Ser Glu Asp Thr Ala Met Tyr Tyr Cys Ala Arg Asp 
                245                 250                 255     


Glu Val Arg Gly Tyr Leu Asp Val Trp Gly Ala Gly Thr Thr Val Thr 
            260                 265                 270         


Val Ser Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro 
        275                 280                 285             


Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro 
    290                 295                 300                 


Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp 
305                 310                 315                 320 


Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu 
                325                 330                 335     


Ser Leu Val Ile Thr Leu Tyr Cys Arg Ser Lys Arg Ser Arg Leu Leu 
            340                 345                 350         


His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg 
        355                 360                 365             


Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg 
    370                 375                 380                 


Ser Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln 
385                 390                 395                 400 


Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu 
                405                 410                 415     


Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly 
            420                 425                 430         


Lys Pro Gln Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu 
        435                 440                 445             


Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly 
    450                 455                 460                 


Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser 
465                 470                 475                 480 


Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro 
                485                 490                 495     


Pro Arg Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly 
            500                 505                 510         


Asp Val Glu Glu Asn Pro Gly Pro Met Tyr Arg Met Gln Leu Leu Ser 
        515                 520                 525             


Cys Ile Ala Leu Ser Leu Ala Leu Val Thr Asn Ser Gly Ile His Val 
    530                 535                 540                 


Phe Ile Leu Gly Cys Phe Ser Ala Gly Leu Pro Lys Thr Glu Ala Asn 
545                 550                 555                 560 


Trp Val Asn Val Ile Ser Asp Leu Lys Lys Ile Glu Asp Leu Ile Gln 
                565                 570                 575     


Ser Met His Ile Asp Ala Thr Leu Tyr Thr Glu Ser Asp Val His Pro 
            580                 585                 590         


Ser Cys Lys Val Thr Ala Met Lys Cys Phe Leu Leu Glu Leu Gln Val 
        595                 600                 605             


Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile His Asp Thr Val Glu Asn 
    610                 615                 620                 


Leu Ile Ile Leu Ala Asn Asn Ser Leu Ser Ser Asn Gly Asn Val Thr 
625                 630                 635                 640 


Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu Lys Asn Ile Lys 
                645                 650                 655     


Glu Phe Leu Gln Ser Phe Val His Ile Val Gln Met Phe Ile Asn Thr 
            660                 665                 670         


Ser Ser Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        675                 680                 685             


Gly Gly Gly Gly Ser Gly Gly Gly Ser Leu Gln Ala Pro Arg Arg Ala 
    690                 695                 700                 


Arg Gly Cys Arg Thr Leu Gly Leu Pro Ala Leu Leu Leu Leu Leu Leu 
705                 710                 715                 720 


Leu Arg Pro Pro Ala Thr Arg Gly Ile Thr Cys Pro Pro Pro Met Ser 
                725                 730                 735     


Val Glu His Ala Asp Ile Trp Val Lys Ser Tyr Ser Leu Tyr Ser Arg 
            740                 745                 750         


Glu Arg Tyr Ile Cys Asn Ser Gly Phe Lys Arg Lys Ala Gly Thr Ser 
        755                 760                 765             


Ser Leu Thr Glu Cys Val Leu Asn Lys Ala Thr Asn Val Ala His Trp 
    770                 775                 780                 


Thr Thr Pro Ser Leu Lys Cys Ile Arg 
785                 790             


<210>  107
<211>  2359
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  107
gcgatcgcac catggcctta ccagtgaccg ccttgctcct gccgctggcc ttgctgctcc       60

acgccgccag gccggacatc caggtgaccc agagccccag cagcctgagc gccagcctgg      120

gcgagagaat cagcctgacc tgcagaacca gccaggacat cagcaactac ctgaactggt      180

tccagcagaa gcccgacggc accttcaaga gactgatcta cgccaccagc agcctggaca      240

gcggcgtgcc caagagattc agcggcagcg gcagcggcag cgactacagc ctgaccatca      300

gcagcctgga gagcgaggac ttcgccgact actactgcct gcagtacgcc agctacccct      360

tcaccttcgg cagcggcacc aagctggaga tcaagggagg ggggggatcc gggggaggag      420

gctccggcgg aggcggaagc gaggtgcagc tgcaggagag cggccccggc ctggtgaagc      480

ccagccagac cctgagcctg acctgcagcg tgaccggcta cagcatcacc agcggctact      540

actggcactg gatcagacag ttccccggca acaagctgca gtggatgggc tacatcagct      600

acagcggctt caccaactac aagaccagcc tgatcaacag aatcagcatc acccacgaca      660

ccagcgagaa ccagttcttc ctgaacctga acagcgtgac caccgaggac accgccacct      720

actactgcgc cggcgacaga accggcagct ggttcgccta ctggggccag ggcaccctgg      780

tgaccgtgag cgccaccacg acgccagcgc cgcgaccacc aacaccggcg cccaccatcg      840

cgtcgcagcc cctgtccctg cgcccagagg cgtgccggcc agcggcgggg ggcgcagtgc      900

acacgagggg gctggacttc gcctgtgata tctacatctg ggcgcccttg gccgggactt      960

gtggggtcct tctcctgtca ctggttatca ccctttactg caggagtaag aggagcaggc     1020

tcctgcacag tgactacatg aacatgactc cccgccgccc cgggcccacc cgcaagcatt     1080

accagcccta tgccccacca cgcgacttcg cagcctatcg ctccagagtg aagttcagca     1140

ggagcgcaga cgcccccgcg taccagcagg gccagaacca gctctataac gagctcaatc     1200

taggacgaag agaggagtac gatgttttgg acaagagacg tggccgggac cctgagatgg     1260

ggggaaagcc gcagagaagg aagaaccctc aggaaggcct gtacaatgaa ctgcagaaag     1320

ataagatggc ggaggcctac agtgagattg ggatgaaagg cgagcgccgg aggggcaagg     1380

ggcacgatgg cctttaccag ggtctcagta cagccaccaa ggacacctac gacgcccttc     1440

acatgcaggc cctgccccct cgcggaagcg gagccaccaa cttcagcctg ctgaagcagg     1500

ccggcgacgt ggaggagaac cccggcccca tgtacagaat gcagctgctg agctgcatcg     1560

ccctgagcct ggccctggtg accaacagcg gcatccacgt gttcatcctg ggctgcttca     1620

gcgccggcct gcccaagacc gaggccaact gggtgaacgt gatcagcgac ctgaagaaga     1680

tcgaggacct gatccagagc atgcacatcg acgccaccct gtacaccgag agcgacgtgc     1740

accccagctg caaggtgacc gccatgaagt gcttcctgct ggagctgcag gtgatcagcc     1800

tggagagcgg cgacgccagc atccacgaca ccgtggagaa cctgatcatc ctggccaaca     1860

acagcctgag cagcaacggc aacgtgaccg agagcggctg caaggagtgc gaggagctgg     1920

aggagaagaa catcaaggag ttcctgcaga gcttcgtgca catcgtgcag atgttcatca     1980

acaccagctc cggcggcggc tccggcggcg gcggctccgg cggcggcggc tccggcggcg     2040

gcggctccgg cggcggctcc ctgcaggccc ccagaagagc cagaggctgc agaaccctgg     2100

gcctgcccgc cctgctgctg ctgctgctgc tgagaccccc cgccaccaga ggcatcacct     2160

gccccccccc catgagcgtg gagcacgccg acatctgggt gaagagctac agcctgtaca     2220

gcagagagag atacatctgc aacagcggct tcaagagaaa ggccggcacc agcagcctga     2280

ccgagtgcgt gctgaacaag gccaccaacg tggcccactg gaccaccccc agcctgaagt     2340

gcatcagata agtttaaac                                                  2359


<210>  108
<211>  779
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  108

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Asp Ile Gln Val Thr Gln Ser Pro Ser Ser Leu 
            20                  25                  30          


Ser Ala Ser Leu Gly Glu Arg Ile Ser Leu Thr Cys Arg Thr Ser Gln 
        35                  40                  45              


Asp Ile Ser Asn Tyr Leu Asn Trp Phe Gln Gln Lys Pro Asp Gly Thr 
    50                  55                  60                  


Phe Lys Arg Leu Ile Tyr Ala Thr Ser Ser Leu Asp Ser Gly Val Pro 
65                  70                  75                  80  


Lys Arg Phe Ser Gly Ser Gly Ser Gly Ser Asp Tyr Ser Leu Thr Ile 
                85                  90                  95      


Ser Ser Leu Glu Ser Glu Asp Phe Ala Asp Tyr Tyr Cys Leu Gln Tyr 
            100                 105                 110         


Ala Ser Tyr Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu 
    130                 135                 140                 


Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln Thr 
145                 150                 155                 160 


Leu Ser Leu Thr Cys Ser Val Thr Gly Tyr Ser Ile Thr Ser Gly Tyr 
                165                 170                 175     


Tyr Trp His Trp Ile Arg Gln Phe Pro Gly Asn Lys Leu Gln Trp Met 
            180                 185                 190         


Gly Tyr Ile Ser Tyr Ser Gly Phe Thr Asn Tyr Lys Thr Ser Leu Ile 
        195                 200                 205             


Asn Arg Ile Ser Ile Thr His Asp Thr Ser Glu Asn Gln Phe Phe Leu 
    210                 215                 220                 


Asn Leu Asn Ser Val Thr Thr Glu Asp Thr Ala Thr Tyr Tyr Cys Ala 
225                 230                 235                 240 


Gly Asp Arg Thr Gly Ser Trp Phe Ala Tyr Trp Gly Gln Gly Thr Leu 
                245                 250                 255     


Val Thr Val Ser Ala Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro 
            260                 265                 270         


Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys 
        275                 280                 285             


Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala 
    290                 295                 300                 


Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu 
305                 310                 315                 320 


Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Arg Ser Lys Arg Ser Arg 
                325                 330                 335     


Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro 
            340                 345                 350         


Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala 
        355                 360                 365             


Tyr Arg Ser Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr 
    370                 375                 380                 


Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg 
385                 390                 395                 400 


Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met 
                405                 410                 415     


Gly Gly Lys Pro Gln Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn 
            420                 425                 430         


Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met 
        435                 440                 445             


Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly 
    450                 455                 460                 


Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala 
465                 470                 475                 480 


Leu Pro Pro Arg Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln 
                485                 490                 495     


Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met Tyr Arg Met Gln Leu 
            500                 505                 510         


Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu Val Thr Asn Ser Gly Ile 
        515                 520                 525             


His Val Phe Ile Leu Gly Cys Phe Ser Ala Gly Leu Pro Lys Thr Glu 
    530                 535                 540                 


Ala Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys Ile Glu Asp Leu 
545                 550                 555                 560 


Ile Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr Glu Ser Asp Val 
                565                 570                 575     


His Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe Leu Leu Glu Leu 
            580                 585                 590         


Gln Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile His Asp Thr Val 
        595                 600                 605             


Glu Asn Leu Ile Ile Leu Ala Asn Asn Ser Leu Ser Ser Asn Gly Asn 
    610                 615                 620                 


Val Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu Lys Asn 
625                 630                 635                 640 


Ile Lys Glu Phe Leu Gln Ser Phe Val His Ile Val Gln Met Phe Ile 
                645                 650                 655     


Asn Thr Ser Ser Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
            660                 665                 670         


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Leu Gln Ala Pro Arg 
        675                 680                 685             


Arg Ala Arg Gly Cys Arg Thr Leu Gly Leu Pro Ala Leu Leu Leu Leu 
    690                 695                 700                 


Leu Leu Leu Arg Pro Pro Ala Thr Arg Gly Ile Thr Cys Pro Pro Pro 
705                 710                 715                 720 


Met Ser Val Glu His Ala Asp Ile Trp Val Lys Ser Tyr Ser Leu Tyr 
                725                 730                 735     


Ser Arg Glu Arg Tyr Ile Cys Asn Ser Gly Phe Lys Arg Lys Ala Gly 
            740                 745                 750         


Thr Ser Ser Leu Thr Glu Cys Val Leu Asn Lys Ala Thr Asn Val Ala 
        755                 760                 765             


His Trp Thr Thr Pro Ser Leu Lys Cys Ile Arg 
    770                 775                 


<210>  109
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  109

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro 
            20      


<210>  110
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  110

Asp Ile Val Met Ser Gln Ser Pro Ser Ser Leu Ala Val Ser Val Gly 
1               5                   10                  15      


Glu Lys Phe Thr Val Asn Cys Lys Ser Ser Gln Ser Leu Leu Tyr Ser 
            20                  25                  30          


Ser Asn Gln Lys Asn Phe Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ile Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Lys Ala Glu Asp Leu Ala Val Tyr Tyr Cys Gln Gln 
                85                  90                  95      


His Tyr Arg Tyr Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Lys Arg Ala Arg 
        115     


<210>  111
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  111

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  112
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  112

Gln Val Thr Leu Lys Glu Ser Gly Pro Gly Ile Leu Gln Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ser Phe Ser Gly Phe Ser Leu Asn Thr Ser 
            20                  25                  30          


Gly Val Gly Val Gly Trp Ile Arg Gln Pro Ser Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Leu Ala His Ile Trp Trp Asp Asp Asp Glu Arg Tyr Asn Pro Val 
    50                  55                  60                  


Leu Lys Ser Arg Leu Thr Ile Ser Lys Asp Thr Ser Ser Asn Gln Val 
65                  70                  75                  80  


Phe Leu Lys Ile Ala Asn Val Asp Thr Ala Asp Ser Ala Thr Tyr Tyr 
                85                  90                  95      


Cys Val Arg Ser Met Val Ala Trp Phe Phe Pro Tyr Trp Gly Arg Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ala 
        115                 


<210>  113
<211>  45
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  113

Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala 
1               5                   10                  15      


Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly 
            20                  25                  30          


Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp 
        35                  40                  45  


<210>  114
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  114

Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu 
1               5                   10                  15      


Ser Leu Val Ile Thr Leu Tyr Cys 
            20                  


<210>  115
<211>  41
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  115

Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr 
1               5                   10                  15      


Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro 
            20                  25                  30          


Pro Arg Asp Phe Ala Ala Tyr Arg Ser 
        35                  40      


<210>  116
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  116

Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly 
1               5                   10                  15      


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
            20                  25                  30          


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
        35                  40                  45              


Pro Gln Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln 
    50                  55                  60                  


Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu 
65                  70                  75                  80  


Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr 
                85                  90                  95      


Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro 
            100                 105                 110         


Arg 
    


<210>  117
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  117

Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val 
1               5                   10                  15      


Glu Glu Asn Pro Gly Pro 
            20          


<210>  118
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  118

Met Tyr Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu 
1               5                   10                  15      


Val Thr Asn Ser 
            20  


<210>  119
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  119

Gly Ile His Val Phe Ile Leu Gly Cys Phe Ser Ala Gly Leu Pro Lys 
1               5                   10                  15      


Thr Glu Ala Asn Trp 
            20      


<210>  120
<211>  50
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  120

Val Asn Val Ile Ser Asp Leu Lys Lys Ile Glu Asp Leu Ile Gln Ser 
1               5                   10                  15      


Met His Ile Asp Ala Thr Leu Tyr Thr Glu Ser Asp Val His Pro Ser 
            20                  25                  30          


Cys Lys Val Thr Ala Met Lys Cys Phe Leu Leu Glu Leu Gln Val Ile 
        35                  40                  45              


Ser Leu 
    50  


<210>  121
<211>  50
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  121

Glu Ser Gly Asp Ala Ser Ile His Asp Thr Val Glu Asn Leu Ile Ile 
1               5                   10                  15      


Leu Ala Asn Asn Ser Leu Ser Ser Asn Gly Asn Val Thr Glu Ser Gly 
            20                  25                  30          


Cys Lys Glu Cys Glu Glu Leu Glu Glu Lys Asn Ile Lys Glu Phe Leu 
        35                  40                  45              


Gln Ser 
    50  


<210>  122
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  122

Phe Val His Ile Val Gln Met Phe Ile Asn Thr Ser 
1               5                   10          


<210>  123
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  123

Ser Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser Gly Gly Gly Ser Leu Gln 
            20                  25      


<210>  124
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  124

Ala Pro Arg Arg Ala Arg Gly Cys Arg Thr Leu Gly Leu Pro Ala Leu 
1               5                   10                  15      


Leu Leu Leu Leu Leu Leu Arg Pro Pro Ala Thr Arg Gly 
            20                  25                  


<210>  125
<211>  65
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  125

Ile Thr Cys Pro Pro Pro Met Ser Val Glu His Ala Asp Ile Trp Val 
1               5                   10                  15      


Lys Ser Tyr Ser Leu Tyr Ser Arg Glu Arg Tyr Ile Cys Asn Ser Gly 
            20                  25                  30          


Phe Lys Arg Lys Ala Gly Thr Ser Ser Leu Thr Glu Cys Val Leu Asn 
        35                  40                  45              


Lys Ala Thr Asn Val Ala His Trp Thr Thr Pro Ser Leu Lys Cys Ile 
    50                  55                  60                  


Arg 
65  


<210>  126
<211>  787
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  (CD19b-28-IL-15/IL-15sushi CAR amino acid sequence)

<400>  126

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu 
            20                  25                  30          


Ile Lys Pro Gly Ala Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr 
        35                  40                  45              


Thr Phe Thr Ser Tyr Val Met His Trp Val Lys Gln Lys Pro Gly Gln 
    50                  55                  60                  


Gly Leu Glu Trp Ile Gly Tyr Ile Asn Pro Tyr Asn Asp Gly Thr Lys 
65                  70                  75                  80  


Tyr Asn Glu Lys Phe Lys Gly Lys Ala Thr Leu Thr Ser Asp Lys Ser 
                85                  90                  95      


Ser Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Thr Ser Glu Asp Ser 
            100                 105                 110         


Ala Val Tyr Tyr Cys Ala Arg Gly Thr Tyr Tyr Tyr Gly Ser Arg Val 
        115                 120                 125             


Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val 
145                 150                 155                 160 


Met Thr Gln Ala Ala Pro Ser Ile Pro Val Thr Pro Gly Glu Ser Val 
                165                 170                 175     


Ser Ile Ser Cys Arg Ser Ser Lys Ser Leu Leu Asn Ser Asn Gly Asn 
            180                 185                 190         


Thr Tyr Leu Tyr Trp Phe Leu Gln Arg Pro Gly Gln Ser Pro Gln Leu 
        195                 200                 205             


Leu Ile Tyr Arg Met Ser Asn Leu Ala Ser Gly Val Pro Asp Arg Phe 
    210                 215                 220                 


Ser Gly Ser Gly Ser Gly Thr Ala Phe Thr Leu Arg Ile Ser Arg Val 
225                 230                 235                 240 


Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln His Leu Glu Tyr 
                245                 250                 255     


Pro Phe Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Arg Thr Thr 
            260                 265                 270         


Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln 
        275                 280                 285             


Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala 
    290                 295                 300                 


Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala 
305                 310                 315                 320 


Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr 
                325                 330                 335     


Leu Tyr Cys Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met 
            340                 345                 350         


Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro 
        355                 360                 365             


Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Arg Val Lys Phe 
    370                 375                 380                 


Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu 
385                 390                 395                 400 


Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp 
                405                 410                 415     


Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Gln Arg Arg 
            420                 425                 430         


Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met 
        435                 440                 445             


Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly 
    450                 455                 460                 


Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp 
465                 470                 475                 480 


Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg Gly Ser Gly 
                485                 490                 495     


Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp Val Glu Glu Asn Pro 
            500                 505                 510         


Gly Pro Met Tyr Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu 
        515                 520                 525             


Ala Leu Val Thr Asn Ser Gly Ile His Val Phe Ile Leu Gly Cys Phe 
    530                 535                 540                 


Ser Ala Gly Leu Pro Lys Thr Glu Ala Asn Trp Val Asn Val Ile Ser 
545                 550                 555                 560 


Asp Leu Lys Lys Ile Glu Asp Leu Ile Gln Ser Met His Ile Asp Ala 
                565                 570                 575     


Thr Leu Tyr Thr Glu Ser Asp Val His Pro Ser Cys Lys Val Thr Ala 
            580                 585                 590         


Met Lys Cys Phe Leu Leu Glu Leu Gln Val Ile Ser Leu Glu Ser Gly 
        595                 600                 605             


Asp Ala Ser Ile His Asp Thr Val Glu Asn Leu Ile Ile Leu Ala Asn 
    610                 615                 620                 


Asn Ser Leu Ser Ser Asn Gly Asn Val Thr Glu Ser Gly Cys Lys Glu 
625                 630                 635                 640 


Cys Glu Glu Leu Glu Glu Lys Asn Ile Lys Glu Phe Leu Gln Ser Phe 
                645                 650                 655     


Val His Ile Val Gln Met Phe Ile Asn Thr Ser Ser Gly Gly Gly Ser 
            660                 665                 670         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        675                 680                 685             


Gly Gly Ser Leu Gln Ala Pro Arg Arg Ala Arg Gly Cys Arg Thr Leu 
    690                 695                 700                 


Gly Leu Pro Ala Leu Leu Leu Leu Leu Leu Leu Arg Pro Pro Ala Thr 
705                 710                 715                 720 


Arg Gly Ile Thr Cys Pro Pro Pro Met Ser Val Glu His Ala Asp Ile 
                725                 730                 735     


Trp Val Lys Ser Tyr Ser Leu Tyr Ser Arg Glu Arg Tyr Ile Cys Asn 
            740                 745                 750         


Ser Gly Phe Lys Arg Lys Ala Gly Thr Ser Ser Leu Thr Glu Cys Val 
        755                 760                 765             


Leu Asn Lys Ala Thr Asn Val Ala His Trp Thr Thr Pro Ser Leu Lys 
    770                 775                 780                 


Cys Ile Arg 
785         


<210>  127
<211>  2372
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  (CD19b-28-IL-15/IL-15sushi CAR nucleotide sequence)

<400>  127
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccggaggtcc agctgcagca gtctggacct gagctgataa agcctggggc ttcagtgaag      120

atgtcctgca aggcttctgg atacacattc actagctatg ttatgcactg ggtgaagcag      180

aagcctgggc agggccttga gtggattgga tatattaatc cttacaatga tggtactaag      240

tacaatgaga agttcaaagg caaggccaca ctgacttcag acaaatcctc cagcacagcc      300

tacatggagc tcagcagcct gacctctgag gactctgcgg tctattactg tgcaagaggg      360

acttattact acggtagtag ggtatttgac tactggggcc aaggcaccac tctcacagtc      420

tcctcaggtg gagggggctc aggcggaggt ggctctgggg gtggaggctc ggacattgtg      480

atgactcagg ctgcaccctc tatacctgtc actcctggag agtcagtatc catctcctgc      540

aggtctagta agagtctcct gaatagtaat ggcaacactt acttgtattg gttcctgcag      600

aggccaggcc agtctcctca gctcctgata tatcggatgt ccaaccttgc ctcaggagtc      660

ccagacaggt tcagtggcag tgggtcagga actgctttca cactgagaat cagtagagtg      720

gaggctgagg atgtgggtgt ttattactgt atgcaacatc tagaatatcc gttcacgttc      780

ggtgctggga ccaagctgga gctgaaacgg accacgacgc cagcgccgcg accaccaaca      840

ccggcgccca ccatcgcgtc gcagcccctg tccctgcgcc cagaggcgtg ccggccagcg      900

gcggggggcg cagtgcacac gagggggctg gacttcgcct gtgatatcta catctgggcg      960

cccttggccg ggacttgtgg ggtccttctc ctgtcactgg ttatcaccct ttactgcagg     1020

agtaagagga gcaggctcct gcacagtgac tacatgaaca tgactccccg ccgccccggg     1080

cccacccgca agcattacca gccctatgcc ccaccacgcg acttcgcagc ctatcgctcc     1140

agagtgaagt tcagcaggag cgcagacgcc cccgcgtacc agcagggcca gaaccagctc     1200

tataacgagc tcaatctagg acgaagagag gagtacgatg ttttggacaa gagacgtggc     1260

cgggaccctg agatgggggg aaagccgcag agaaggaaga accctcagga aggcctgtac     1320

aatgaactgc agaaagataa gatggcggag gcctacagtg agattgggat gaaaggcgag     1380

cgccggaggg gcaaggggca cgatggcctt taccagggtc tcagtacagc caccaaggac     1440

acctacgacg cccttcacat gcaggccctg ccccctcgcg gcagcggcga aggccgcggc     1500

agcctgctga cctgcggcga tgtggaagaa aacccgggcc ccatgtacag aatgcagctg     1560

ctgagctgca tcgccctgag cctggccctg gtgaccaaca gcggcatcca cgtgttcatc     1620

ctgggctgct tcagcgccgg cctgcccaag accgaggcca actgggtgaa cgtgatcagc     1680

gacctgaaga agatcgagga cctgatccag agcatgcaca tcgacgccac cctgtacacc     1740

gagagcgacg tgcaccccag ctgcaaggtg accgccatga agtgcttcct gctggagctg     1800

caggtgatca gcctggagag cggcgacgcc agcatccacg acaccgtgga gaacctgatc     1860

atcctggcca acaacagcct gagcagcaac ggcaacgtga ccgagagcgg ctgcaaggag     1920

tgcgaggagc tggaggagaa gaacatcaag gagttcctgc agagcttcgt gcacatcgtg     1980

cagatgttca tcaacaccag ctccggcggc ggctccggcg gcggcggctc cggcggcggc     2040

ggctccggcg gcggcggctc cggcggcggc tccctgcagg cccccagaag agccagaggc     2100

tgcagaaccc tgggcctgcc cgccctgctg ctgctgctgc tgctgagacc ccccgccacc     2160

agaggcatca cctgcccccc ccccatgagc gtggagcacg ccgacatctg ggtgaagagc     2220

tacagcctgt acagcagaga gagatacatc tgcaacagcg gcttcaagag aaaggccggc     2280

accagcagcc tgaccgagtg cgtgctgaac aaggccacca acgtggccca ctggaccacc     2340

cccagcctga agtgcatcag ataagtttaa ac                                   2372


<210>  128
<211>  1024
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  (CD19b-BBpre-P2A-CD123b-2G CAR amino acid sequence)

<400>  128

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu 
            20                  25                  30          


Ile Lys Pro Gly Ala Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr 
        35                  40                  45              


Thr Phe Thr Ser Tyr Val Met His Trp Val Lys Gln Lys Pro Gly Gln 
    50                  55                  60                  


Gly Leu Glu Trp Ile Gly Tyr Ile Asn Pro Tyr Asn Asp Gly Thr Lys 
65                  70                  75                  80  


Tyr Asn Glu Lys Phe Lys Gly Lys Ala Thr Leu Thr Ser Asp Lys Ser 
                85                  90                  95      


Ser Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Thr Ser Glu Asp Ser 
            100                 105                 110         


Ala Val Tyr Tyr Cys Ala Arg Gly Thr Tyr Tyr Tyr Gly Ser Arg Val 
        115                 120                 125             


Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val 
145                 150                 155                 160 


Met Thr Gln Ala Ala Pro Ser Ile Pro Val Thr Pro Gly Glu Ser Val 
                165                 170                 175     


Ser Ile Ser Cys Arg Ser Ser Lys Ser Leu Leu Asn Ser Asn Gly Asn 
            180                 185                 190         


Thr Tyr Leu Tyr Trp Phe Leu Gln Arg Pro Gly Gln Ser Pro Gln Leu 
        195                 200                 205             


Leu Ile Tyr Arg Met Ser Asn Leu Ala Ser Gly Val Pro Asp Arg Phe 
    210                 215                 220                 


Ser Gly Ser Gly Ser Gly Thr Ala Phe Thr Leu Arg Ile Ser Arg Val 
225                 230                 235                 240 


Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln His Leu Glu Tyr 
                245                 250                 255     


Pro Phe Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Arg Thr Thr 
            260                 265                 270         


Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln 
        275                 280                 285             


Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala 
    290                 295                 300                 


Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala 
305                 310                 315                 320 


Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr 
                325                 330                 335     


Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln 
            340                 345                 350         


Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser 
        355                 360                 365             


Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys 
    370                 375                 380                 


Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln 
385                 390                 395                 400 


Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu 
                405                 410                 415     


Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Gln Arg 
            420                 425                 430         


Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys 
        435                 440                 445             


Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg 
    450                 455                 460                 


Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys 
465                 470                 475                 480 


Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg Gly Ser 
                485                 490                 495     


Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu 
            500                 505                 510         


Asn Pro Gly Pro Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu 
        515                 520                 525             


Ala Leu Leu Leu His Ala Ala Arg Pro Met Ala Asp Tyr Lys Asp Ile 
    530                 535                 540                 


Val Met Thr Gln Ser His Lys Phe Met Ser Thr Ser Val Gly Asp Arg 
545                 550                 555                 560 


Val Asn Ile Thr Cys Lys Ala Ser Gln Asn Val Asp Ser Ala Val Ala 
                565                 570                 575     


Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Ala Leu Ile Tyr Ser 
            580                 585                 590         


Ala Ser Tyr Arg Tyr Ser Gly Val Pro Asp Arg Phe Thr Gly Arg Gly 
        595                 600                 605             


Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Val Gln Ala Glu Asp 
    610                 615                 620                 


Leu Ala Val Tyr Tyr Cys Gln Gln Tyr Tyr Ser Thr Pro Trp Thr Phe 
625                 630                 635                 640 


Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Gly Gly Gly Gly Ser Gly 
                645                 650                 655     


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val 
            660                 665                 670         


Lys Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu 
        675                 680                 685             


Ser Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Thr Asp Tyr Tyr Met 
    690                 695                 700                 


Ser Trp Val Arg Gln Pro Pro Gly Lys Ala Leu Glu Trp Leu Ala Leu 
705                 710                 715                 720 


Ile Arg Ser Lys Ala Asp Gly Tyr Thr Thr Glu Tyr Ser Ala Ser Val 
                725                 730                 735     


Lys Gly Arg Phe Thr Leu Ser Arg Asp Asp Ser Gln Ser Ile Leu Tyr 
            740                 745                 750         


Leu Gln Met Asn Ala Leu Arg Pro Glu Asp Ser Ala Thr Tyr Tyr Cys 
        755                 760                 765             


Ala Arg Asp Ala Ala Tyr Tyr Ser Tyr Tyr Ser Pro Glu Gly Ala Met 
    770                 775                 780                 


Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Ala Ser Gly 
785                 790                 795                 800 


Ala Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile 
                805                 810                 815     


Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala 
            820                 825                 830         


Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr 
        835                 840                 845             


Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu 
    850                 855                 860                 


Val Ile Thr Leu Tyr Cys Arg Ser Lys Arg Ser Arg Leu Leu His Ser 
865                 870                 875                 880 


Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His 
                885                 890                 895     


Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Arg 
            900                 905                 910         


Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln 
        915                 920                 925             


Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp 
    930                 935                 940                 


Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro 
945                 950                 955                 960 


Gln Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys 
                965                 970                 975     


Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg 
            980                 985                 990         


Arg Arg Gly Lys Gly His Asp Gly  Leu Tyr Gln Gly Leu  Ser Thr Ala 
        995                 1000                 1005             


Thr Lys  Asp Thr Tyr Asp Ala  Leu His Met Gln Ala  Leu Pro Pro 
    1010                 1015                 1020             


Arg 
    


<210>  129
<211>  3083
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  (CD19b-BBpre-P2A-CD123b-2G CAR nucleotide sequence)

<400>  129
atggccctgc ccgtgaccgc cctgctgctg cccctggccc tgctgctgca cgccgccagg       60

cccgaggtcc agctgcagca gtctggacct gagctgataa agcctggggc ttcagtgaag      120

atgtcctgca aggcttctgg atacacattc actagctatg ttatgcactg ggtgaagcag      180

aagcctgggc agggccttga gtggattgga tatattaatc cttacaatga tggtactaag      240

tacaatgaga agttcaaagg caaggccaca ctgacttcag acaaatcctc cagcacagcc      300

tacatggagc tcagcagcct gacctctgag gactctgcgg tctattactg tgcaagaggg      360

acttattact acggtagtag ggtatttgac tactggggcc aaggcaccac tctcacagtc      420

tcctcaggtg gagggggctc aggcggaggt ggctctgggg gtggaggctc ggacattgtg      480

atgactcagg ctgcaccctc tatacctgtc actcctggag agtcagtatc catctcctgc      540

aggtctagta agagtctcct gaatagtaat ggcaacactt acttgtattg gttcctgcag      600

aggccaggcc agtctcctca gctcctgata tatcggatgt ccaaccttgc ctcaggagtc      660

ccagacaggt tcagtggcag tgggtcagga actgctttca cactgagaat cagtagagtg      720

gaggctgagg atgtgggtgt ttattactgt atgcaacatc tagaatatcc gttcacgttc      780

ggtgctggga ccaagctgga gctgaaacgg accaccaccc ccgcccccag gccccccacc      840

cccgccccca ccatcgccag ccagcccctg agcctgaggc ccgaggcctg caggcccgcc      900

gccggcggcg ccgtgcacac caggggcctg gacttcgcct gcgacatcta catctgggcc      960

cccctggccg gcacctgcgg cgtgctgctg ctgagcctgg tgatcaccct gtactgcaaa     1020

cggggcagaa agaaactcct gtatatattc aaacaaccat ttatgagacc agtacaaact     1080

actcaagagg aagatggctg tagctgccga tttccagaag aagaagaagg aggatgtgaa     1140

ctgagggtga agttcagcag gagcgccgac gcccccgcct accagcaggg ccagaaccag     1200

ctgtacaacg agctgaacct gggcaggagg gaggagtacg acgtgctgga caagaggagg     1260

ggcagggacc ccgagatggg cggcaagccc cagaggagga agaaccccca ggagggcctg     1320

tacaacgagc tgcagaagga caagatggcc gaggcctaca gcgagatcgg catgaagggc     1380

gagaggagga ggggcaaggg ccacgacggc ctgtaccagg gcctgagcac cgccaccaag     1440

gacacctacg acgccctgca catgcaggcc ctgcccccca ggggaagcgg agccaccaac     1500

ttcagcctgc tgaagcaggc cggcgacgtg gaggagaacc ccggccccat ggccttacca     1560

gtgaccgcct tgctcctgcc gctggccttg ctgctccacg ccgccaggcc gatggccgac     1620

tacaaggaca tcgtgatgac ccagagccac aagttcatga gcaccagcgt gggcgacagg     1680

gtgaacatca cctgcaaggc cagccagaac gtggacagcg ccgtggcctg gtaccagcag     1740

aagcccggcc agagccccaa ggccctgatc tacagcgcca gctacaggta cagcggcgtg     1800

cccgacaggt tcaccggcag gggcagcggc accgacttca ccctgaccat cagcagcgtg     1860

caggccgagg acctggccgt gtactactgc cagcagtact acagcacccc ctggaccttc     1920

ggcggcggca ccaagctgga gatcaagagg ggcggcggcg gcagcggcgg cggcggcagc     1980

ggcggcggcg gcagcggcgg cggcggcagc gaggtgaagc tggtggagag cggcggcggc     2040

ctggtgcagc ccggcggcag cctgagcctg agctgcgccg ccagcggctt caccttcacc     2100

gactactaca tgagctgggt gaggcagccc cccggcaagg ccctggagtg gctggccctg     2160

atcaggagca aggccgacgg ctacaccacc gagtacagcg ccagcgtgaa gggcaggttc     2220

accctgagca gggacgacag ccagagcatc ctgtacctgc agatgaacgc cctgaggccc     2280

gaggacagcg ccacctacta ctgcgccagg gacgccgcct actacagcta ctacagcccc     2340

gagggcgcca tggactactg gggccagggc accagcgtga ccgtgagcag cgccagcggc     2400

gccaccacga cgccagcgcc gcgaccacca acaccggcgc ccaccatcgc gtcgcagccc     2460

ctgtccctgc gcccagaggc gtgccggcca gcggcggggg gcgcagtgca cacgaggggg     2520

ctggacttcg cctgtgatat ctacatctgg gcgcccttgg ccgggacttg tggggtcctt     2580

ctcctgtcac tggttatcac cctttactgc aggagtaaga ggagcaggct cctgcacagt     2640

gactacatga acatgactcc ccgccgcccc gggcccaccc gcaagcatta ccagccctat     2700

gccccaccac gcgacttcgc agcctatcgc tccagagtga agttcagcag gagcgcagac     2760

gcccccgcgt accagcaggg ccagaaccag ctctataacg agctcaatct aggacgaaga     2820

gaggagtacg atgttttgga caagagacgt ggccgggacc ctgagatggg gggaaagccg     2880

cagagaagga agaaccctca ggaaggcctg tacaatgaac tgcagaaaga taagatggcg     2940

gaggcctaca gtgagattgg gatgaaaggc gagcgccgga ggggcaaggg gcacgatggc     3000

ctttaccagg gtctcagtac agccaccaag gacacctacg acgcccttca catgcaggcc     3060

ctgccccctc gctaagttta aac                                             3083


<210>  130
<211>  485
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  (CD22b-28-2G CAR amino acid sequence)

<400>  130

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gln Val Gln Leu Gln Glu Ser Gly Ala Glu Leu 
            20                  25                  30          


Ser Lys Pro Gly Ala Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr 
        35                  40                  45              


Thr Phe Thr Ser Tyr Trp Leu His Trp Ile Lys Gln Arg Pro Gly Gln 
    50                  55                  60                  


Gly Leu Glu Trp Ile Gly Tyr Ile Asn Pro Arg Asn Asp Tyr Thr Glu 
65                  70                  75                  80  


Tyr Asn Gln Asn Phe Lys Asp Lys Ala Thr Leu Thr Ala Asp Lys Ser 
                85                  90                  95      


Ser Ser Thr Ala Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser 
            100                 105                 110         


Ala Val Tyr Tyr Cys Ala Arg Arg Asp Ile Thr Thr Phe Tyr Trp Gly 
        115                 120                 125             


Gln Gly Thr Thr Leu Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Leu Thr Gln Ser Pro 
145                 150                 155                 160 


Ser Ser Leu Ala Val Ser Ala Gly Glu Asn Val Thr Met Ser Cys Lys 
                165                 170                 175     


Ser Ser Gln Ser Val Leu Tyr Ser Ala Asn His Lys Asn Tyr Leu Ala 
            180                 185                 190         


Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile Tyr Trp 
        195                 200                 205             


Ala Ser Thr Arg Glu Ser Gly Val Pro Asp Arg Phe Thr Gly Ser Gly 
    210                 215                 220                 


Thr Asp Phe Thr Leu Thr Ile Ser Arg Val Gln Val Glu Asp Leu Ala 
225                 230                 235                 240 


Ile Tyr Tyr Cys His Gln Tyr Leu Ser Ser Trp Thr Phe Gly Gly Gly 
                245                 250                 255     


Thr Lys Leu Glu Ile Lys Arg Thr Thr Thr Pro Ala Pro Arg Pro Pro 
            260                 265                 270         


Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu 
        275                 280                 285             


Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp 
    290                 295                 300                 


Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly 
305                 310                 315                 320 


Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Arg Ser Lys Arg 
                325                 330                 335     


Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro 
            340                 345                 350         


Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe 
        355                 360                 365             


Ala Ala Tyr Arg Ser Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro 
    370                 375                 380                 


Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly 
385                 390                 395                 400 


Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro 
                405                 410                 415     


Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr 
            420                 425                 430         


Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly 
        435                 440                 445             


Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln 
    450                 455                 460                 


Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln 
465                 470                 475                 480 


Ala Leu Pro Pro Arg 
                485 


<210>  131
<211>  1466
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  (CD22b-28-2G CAR nucleotide sequence)

<400>  131
atggccctgc ccgtgaccgc cctgctgctg cccctggccc tgctgctgca cgccgccagg       60

ccccaggtgc agctgcagga gagcggcgcc gagctgagca agcccggcgc cagcgtgaag      120

atgagctgca aggccagcgg ctacaccttc accagctact ggctgcactg gatcaagcag      180

aggcccggcc agggcctgga gtggatcggc tacatcaacc ccaggaacga ctacaccgag      240

tacaaccaga acttcaagga caaggccacc ctgaccgccg acaagagcag cagcaccgcc      300

tacatgcagc tgagcagcct gaccagcgag gacagcgccg tgtactactg cgccaggagg      360

gacatcacca ccttctactg gggccagggc accaccctga ccgtgagcag cggagggggg      420

ggatccgggg gaggaggctc cggcggaggc ggaagcgaca tccagctgac ccagagcccc      480

agcagcctgg ccgtgagcgc cggcgagaac gtgaccatga gctgcaagag cagccagagc      540

gtgctgtaca gcgccaacca caagaactac ctggcctggt accagcagaa gcccggccag      600

agccccaagc tgctgatcta ctgggccagc accagggaga gcggcgtgcc cgacaggttc      660

accggcagcg gcaccgactt caccctgacc atcagcaggg tgcaggtgga ggacctggcc      720

atctactact gccaccagta cctgagcagc tggaccttcg gcggcggcac caagctggag      780

atcaagagga ccaccacccc cgcccccagg ccccccaccc ccgcccccac catcgccagc      840

cagcccctga gcctgaggcc cgaggcctgc aggcccgccg ccggcggcgc cgtgcacacc      900

aggggcctgg acttcgcctg cgacatctac atctgggccc ccctggccgg cacctgcggc      960

gtgctgctgc tgagcctggt gatcaccctg tactgcagga gtaagaggag caggctcctg     1020

cacagtgact acatgaacat gactccccgc cgccccgggc ccacccgcaa gcattaccag     1080

ccctatgccc caccacgcga cttcgcagcc tatcgctcca gggtgaagtt cagcaggagc     1140

gccgacgccc ccgcctacca gcagggccag aaccagctgt acaacgagct gaacctgggc     1200

aggagggagg agtacgacgt gctggacaag aggaggggca gggaccccga gatgggcggc     1260

aagcccagga ggaagaaccc ccaggagggc ctgtacaacg agctgcagaa ggacaagatg     1320

gccgaggcct acagcgagat cggcatgaag ggcgagagga ggaggggcaa gggccacgac     1380

ggcctgtacc agggcctgag caccgccacc aaggacacct acgacgccct gcacatgcag     1440

gccctgcccc ccaggtaagt ttaaac                                          1466


<210>  132
<211>  497
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  (CD33b-BB-2G CAR amino acid sequence)

<400>  132

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Met Ala Asp Tyr Lys Asp Ile Val Met Thr Gln 
            20                  25                  30          


Ser His Lys Phe Leu Leu Val Ser Val Gly Asp Arg Val Ser Ile Thr 
        35                  40                  45              


Cys Lys Ala Ser Gln Asp Val Ser Thr Ala Val Ala Trp Tyr Gln Gln 
    50                  55                  60                  


Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile Tyr Ser Ala Ser Tyr Arg 
65                  70                  75                  80  


Tyr Thr Gly Val Pro Asp Arg Phe Ile Gly Ser Gly Ser Gly Thr Asp 
                85                  90                  95      


Phe Thr Leu Thr Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Asp Tyr 
            100                 105                 110         


Phe Cys Gln Gln His Tyr Ser Thr Pro Leu Thr Phe Gly Ala Gly Thr 
        115                 120                 125             


Lys Leu Glu Ile Lys Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Ser Gly Gly Gly Ser Glu Val Gln Leu Lys Glu 
145                 150                 155                 160 


Ser Gly Pro Gly Leu Val Ala Pro Ser Gln Ser Leu Ser Ile Thr Cys 
                165                 170                 175     


Thr Val Ser Gly Phe Pro Leu Thr Ser Tyr Gly Val Ser Trp Val Arg 
            180                 185                 190         


Gln Pro Pro Gly Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Gly Asp 
        195                 200                 205             


Gly Ser Thr Asn Tyr His Ser Ala Leu Ile Ser Arg Leu Ser Ile Ser 
    210                 215                 220                 


Lys Asp Asn Ser Lys Ser Gln Val Phe Leu Lys Leu Asn Asn Leu Gln 
225                 230                 235                 240 


Thr Asp Asp Thr Ala Thr Tyr Tyr Cys Ala Arg Asp Thr Tyr Tyr Pro 
                245                 250                 255     


Tyr Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser 
            260                 265                 270         


Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile 
        275                 280                 285             


Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala 
    290                 295                 300                 


Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr 
305                 310                 315                 320 


Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu 
                325                 330                 335     


Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile 
            340                 345                 350         


Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp 
        355                 360                 365             


Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
    370                 375                 380                 


Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly 
385                 390                 395                 400 


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
                405                 410                 415     


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
            420                 425                 430         


Pro Gln Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln 
        435                 440                 445             


Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu 
    450                 455                 460                 


Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr 
465                 470                 475                 480 


Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro 
                485                 490                 495     


Arg 
    


<210>  133
<211>  1494
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  (CD33b-BB-2G CAR nucleotide sequence)

<400>  133
atggccctgc ccgtgaccgc cctgctgctg cccctggccc tgctgctgca cgccgccagg       60

cccatggccg actacaagga catcgtgatg acccagagcc acaagttcct gctggtgagc      120

gtgggcgaca gggtgagcat cacctgcaag gccagccagg acgtgagcac cgccgtggcc      180

tggtaccagc agaagcccgg ccagagcccc aagctgctga tctacagcgc cagctacagg      240

tacaccggcg tgcccgacag gttcatcggc agcggcagcg gcaccgactt caccctgacc      300

atcagcagcg tgcaggccga ggacctggcc gactacttct gccagcagca ctacagcacc      360

cccctgacct tcggcgccgg caccaagctg gagatcaaga ggggcggcgg cggcagcggc      420

ggcggcggca gcggcggcgg cggcagcagc ggcggcggca gcgaggtgca gctgaaggag      480

agcggccccg gcctggtggc ccccagccag agcctgagca tcacctgcac cgtgagcggc      540

ttccccctga ccagctacgg cgtgagctgg gtgaggcagc cccccggcaa gggcctggag      600

tggctgggcg tgatctgggg cgacggcagc accaactacc acagcgccct gatcagcagg      660

ctgagcatca gcaaggacaa cagcaagagc caggtgttcc tgaagctgaa caacctgcag      720

accgacgaca ccgccaccta ctactgcgcc agggacacct actaccccta ctacgccatg      780

gactactggg gccagggcac cagcgtgacc gtgagcagca ccaccacccc cgcccccagg      840

ccccccaccc ccgcccccac catcgccagc cagcccctga gcctgaggcc cgaggcctgc      900

aggcccgccg ccggcggcgc cgtgcacacc aggggcctgg acttcgcctg cgacatctac      960

atctgggccc ccctggccgg cacctgcggc gtgctgctgc tgagcctggt gatcaccctg     1020

tactgcaaac ggggcagaaa gaaactcctg tatatattca aacaaccatt tatgagacca     1080

gtacaaacta ctcaagagga agatggctgt agctgccgat ttccagaaga agaagaagga     1140

ggatgtgaac tgagggtgaa gttcagcagg agcgccgacg cccccgccta ccagcagggc     1200

cagaaccagc tgtacaacga gctgaacctg ggcaggaggg aggagtacga cgtgctggac     1260

aagaggaggg gcagggaccc cgagatgggc ggcaagcccc agaggaggaa gaacccccag     1320

gagggcctgt acaacgagct gcagaaggac aagatggccg aggcctacag cgagatcggc     1380

atgaagggcg agaggaggag gggcaagggc cacgacggcc tgtaccaggg cctgagcacc     1440

gccaccaagg acacctacga cgccctgcac atgcaggccc tgccccccag gtaa           1494


<210>  134
<211>  1060
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  (CD45-28-2G-4-1BBL-IL15RA "super" CAR amino acid sequence)

<400>  134

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu 
            20                  25                  30          


Ala Val Ser Leu Gly Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Lys 
        35                  40                  45              


Ser Val Ser Thr Ser Gly Tyr Ser Tyr Leu His Trp Tyr Gln Gln Lys 
    50                  55                  60                  


Pro Gly Gln Pro Pro Lys Leu Leu Ile Tyr Leu Ala Ser Asn Leu Glu 
65                  70                  75                  80  


Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 
                85                  90                  95      


Thr Leu Asn Ile His Pro Val Glu Glu Glu Asp Ala Ala Thr Tyr Tyr 
            100                 105                 110         


Cys Gln His Ser Arg Glu Leu Pro Phe Thr Phe Gly Ser Gly Thr Lys 
        115                 120                 125             


Leu Glu Ile Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln 
145                 150                 155                 160 


Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Asp Phe 
                165                 170                 175     


Ser Arg Tyr Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
            180                 185                 190         


Glu Trp Ile Gly Glu Ile Asn Pro Thr Ser Ser Thr Ile Asn Phe Thr 
        195                 200                 205             


Pro Ser Leu Lys Asp Lys Val Phe Ile Ser Arg Asp Asn Ala Lys Asn 
    210                 215                 220                 


Thr Leu Tyr Leu Gln Met Ser Lys Val Arg Ser Glu Asp Thr Ala Leu 
225                 230                 235                 240 


Tyr Tyr Cys Ala Arg Gly Asn Tyr Tyr Arg Tyr Gly Asp Ala Met Asp 
                245                 250                 255     


Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Thr Thr Thr Pro Ala 
            260                 265                 270         


Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser 
        275                 280                 285             


Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr 
    290                 295                 300                 


Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala 
305                 310                 315                 320 


Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys 
                325                 330                 335     


Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr 
            340                 345                 350         


Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro 
        355                 360                 365             


Pro Arg Asp Phe Ala Ala Tyr Arg Ser Arg Val Lys Phe Ser Arg Ser 
    370                 375                 380                 


Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu 
385                 390                 395                 400 


Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg 
                405                 410                 415     


Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Gln Arg Arg Lys Asn Pro 
            420                 425                 430         


Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala 
        435                 440                 445             


Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His 
    450                 455                 460                 


Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp 
465                 470                 475                 480 


Ala Leu His Met Gln Ala Leu Pro Pro Arg Gly Ser Gly Glu Gly Arg 
                485                 490                 495     


Gly Ser Leu Leu Thr Cys Gly Asp Val Glu Glu Asn Pro Gly Pro Met 
            500                 505                 510         


Glu Tyr Ala Ser Asp Ala Ser Leu Asp Pro Glu Ala Pro Trp Pro Pro 
        515                 520                 525             


Ala Pro Arg Ala Arg Ala Cys Arg Val Leu Pro Trp Ala Leu Val Ala 
    530                 535                 540                 


Gly Leu Leu Leu Leu Leu Leu Leu Ala Ala Ala Cys Ala Val Phe Leu 
545                 550                 555                 560 


Ala Cys Pro Trp Ala Val Ser Gly Ala Arg Ala Ser Pro Gly Ser Ala 
                565                 570                 575     


Ala Ser Pro Arg Leu Arg Glu Gly Pro Glu Leu Ser Pro Asp Asp Pro 
            580                 585                 590         


Ala Gly Leu Leu Asp Leu Arg Gln Gly Met Phe Ala Gln Leu Val Ala 
        595                 600                 605             


Gln Asn Val Leu Leu Ile Asp Gly Pro Leu Ser Trp Tyr Ser Asp Pro 
    610                 615                 620                 


Gly Leu Ala Gly Val Ser Leu Thr Gly Gly Leu Ser Tyr Lys Glu Asp 
625                 630                 635                 640 


Thr Lys Glu Leu Val Val Ala Lys Ala Gly Val Tyr Tyr Val Phe Phe 
                645                 650                 655     


Gln Leu Glu Leu Arg Arg Val Val Ala Gly Glu Gly Ser Gly Ser Val 
            660                 665                 670         


Ser Leu Ala Leu His Leu Gln Pro Leu Arg Ser Ala Ala Gly Ala Ala 
        675                 680                 685             


Ala Leu Ala Leu Thr Val Asp Leu Pro Pro Ala Ser Ser Glu Ala Arg 
    690                 695                 700                 


Asn Ser Ala Phe Gly Phe Gln Gly Arg Leu Leu His Leu Ser Ala Gly 
705                 710                 715                 720 


Gln Arg Leu Gly Val His Leu His Thr Glu Ala Arg Ala Arg His Ala 
                725                 730                 735     


Trp Gln Leu Thr Gln Gly Ala Thr Val Leu Gly Leu Phe Arg Val Thr 
            740                 745                 750         


Pro Glu Ile Pro Ala Gly Leu Pro Ser Pro Arg Ser Glu Gly Ser Gly 
        755                 760                 765             


Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn 
    770                 775                 780                 


Pro Gly Pro Met Tyr Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser 
785                 790                 795                 800 


Leu Ala Leu Val Thr Asn Ser Gly Ile His Val Phe Ile Leu Gly Cys 
                805                 810                 815     


Phe Ser Ala Gly Leu Pro Lys Thr Glu Ala Asn Trp Val Asn Val Ile 
            820                 825                 830         


Ser Asp Leu Lys Lys Ile Glu Asp Leu Ile Gln Ser Met His Ile Asp 
        835                 840                 845             


Ala Thr Leu Tyr Thr Glu Ser Asp Val His Pro Ser Cys Lys Val Thr 
    850                 855                 860                 


Ala Met Lys Cys Phe Leu Leu Glu Leu Gln Val Ile Ser Leu Glu Ser 
865                 870                 875                 880 


Gly Asp Ala Ser Ile His Asp Thr Val Glu Asn Leu Ile Ile Leu Ala 
                885                 890                 895     


Asn Asn Ser Leu Ser Ser Asn Gly Asn Val Thr Glu Ser Gly Cys Lys 
            900                 905                 910         


Glu Cys Glu Glu Leu Glu Glu Lys Asn Ile Lys Glu Phe Leu Gln Ser 
        915                 920                 925             


Phe Val His Ile Val Gln Met Phe Ile Asn Thr Ser Ser Gly Gly Gly 
    930                 935                 940                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
945                 950                 955                 960 


Gly Gly Gly Ser Leu Gln Ala Pro Arg Arg Ala Arg Gly Cys Arg Thr 
                965                 970                 975     


Leu Gly Leu Pro Ala Leu Leu Leu Leu Leu Leu Leu Arg Pro Pro Ala 
            980                 985                 990         


Thr Arg Gly Ile Thr Cys Pro Pro  Pro Met Ser Val Glu  His Ala Asp 
        995                 1000                 1005             


Ile Trp  Val Lys Ser Tyr Ser  Leu Tyr Ser Arg Glu  Arg Tyr Ile 
    1010                 1015                 1020             


Cys Asn  Ser Gly Phe Lys Arg  Lys Ala Gly Thr Ser  Ser Leu Thr 
    1025                 1030                 1035             


Glu Cys  Val Leu Asn Lys Ala  Thr Asn Val Ala His  Trp Thr Thr 
    1040                 1045                 1050             


Pro Ser  Leu Lys Cys Ile Arg  
    1055                 1060 


<210>  135
<211>  3191
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  (CD45-28-2G-4-1BBL-IL15RA sequence, "super" CAR nucleotide 
       sequence)

<400>  135
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccggacatcg tgctgaccca gagccccgcc agcctggccg tgagcctggg ccagagggcc      120

accatcagct gcagggccag caagagcgtg agcaccagcg gctacagcta cctgcactgg      180

taccagcaga agcccggcca gccccccaag ctgctgatct acctggccag caacctggag      240

agcggcgtgc ccgccaggtt cagcggcagc ggcagcggca ccgacttcac cctgaacatc      300

caccccgtgg aggaggagga cgccgccacc tactactgcc agcacagcag ggagctgccc      360

ttcaccttcg gcagcggcac caagctggag atcaagggag gggggggatc cgggggagga      420

ggctccggcg gaggcggaag ccaggtgcag ctggtggaga gcggcggcgg cctggtgcag      480

cccggcggca gcctgaagct gagctgcgcc gccagcggct tcgacttcag caggtactgg      540

atgagctggg tgaggcaggc ccccggcaag ggcctggagt ggatcggcga gatcaacccc      600

accagcagca ccatcaactt cacccccagc ctgaaggaca aggtgttcat cagcagggac      660

aacgccaaga acaccctgta cctgcagatg agcaaggtga ggagcgagga caccgccctg      720

tactactgcg ccaggggcaa ctactacagg tacggcgacg ccatggacta ctggggccag      780

ggcaccagcg tgaccgtgag caccacgacg ccagcgccgc gaccaccaac accggcgccc      840

accatcgcgt cgcagcccct gtccctgcgc ccagaggcgt gccggccagc ggcggggggc      900

gcagtgcaca cgagggggct ggacttcgcc tgtgatatct acatctgggc gcccttggcc      960

gggacttgtg gggtccttct cctgtcactg gttatcaccc tttactgcag gagtaagagg     1020

agcaggctcc tgcacagtga ctacatgaac atgactcccc gccgccccgg gcccacccgc     1080

aagcattacc agccctatgc cccaccacgc gacttcgcag cctatcgctc cagagtgaag     1140

ttcagcagga gcgcagacgc ccccgcgtac cagcagggcc agaaccagct ctataacgag     1200

ctcaatctag gacgaagaga ggagtacgat gttttggaca agagacgtgg ccgggaccct     1260

gagatggggg gaaagccgca gagaaggaag aaccctcagg aaggcctgta caatgaactg     1320

cagaaagata agatggcgga ggcctacagt gagattggga tgaaaggcga gcgccggagg     1380

ggcaaggggc acgatggcct ttaccagggt ctcagtacag ccaccaagga cacctacgac     1440

gcccttcaca tgcaggccct gccccctcgc ggcagcggcg aaggccgcgg cagcctgctg     1500

acctgcggcg atgtggaaga aaacccgggc cccatggaat acgcctctga cgcttcactg     1560

gaccccgaag ccccgtggcc tcccgcgccc cgcgctcgcg cctgccgcgt actgccttgg     1620

gccctggtcg cggggctgct gctgctgctg ctgctcgctg ccgcctgcgc cgtcttcctc     1680

gcctgcccct gggccgtgtc cggggctcgc gcctcgcccg gctccgcggc cagcccgaga     1740

ctccgcgagg gtcccgagct ttcgcccgac gatcccgccg gcctcttgga cctgcggcag     1800

ggcatgtttg cgcagctggt ggcccaaaat gttctgctga tcgatgggcc cctgagctgg     1860

tacagtgacc caggcctggc aggcgtgtcc ctgacggggg gcctgagcta caaagaggac     1920

acgaaggagc tggtggtggc caaggctgga gtctactatg tcttctttca actagagctg     1980

cggcgcgtgg tggccggcga gggctcaggc tccgtttcac ttgcgctgca cctgcagcca     2040

ctgcgctctg ctgctggggc cgccgccctg gctttgaccg tggacctgcc acccgcctcc     2100

tccgaggctc ggaactcggc cttcggtttc cagggccgct tgctgcacct gagtgccggc     2160

cagcgcctgg gcgtccatct tcacactgag gccagggcac gccatgcctg gcagcttacc     2220

cagggcgcca cagtcttggg actcttccgg gtgacccccg aaatcccagc cggactccct     2280

tcaccgaggt cggaaggaag cggagctact aacttcagcc tgctgaagca ggctggagac     2340

gtggaggaga accctggacc tatgtacaga atgcagctgc tgagctgcat cgccctgagc     2400

ctggccctgg tgaccaacag cggcatccac gtgttcatcc tgggctgctt cagcgccggc     2460

ctgcccaaga ccgaggccaa ctgggtgaac gtgatcagcg acctgaagaa gatcgaggac     2520

ctgatccaga gcatgcacat cgacgccacc ctgtacaccg agagcgacgt gcaccccagc     2580

tgcaaggtga ccgccatgaa gtgcttcctg ctggagctgc aggtgatcag cctggagagc     2640

ggcgacgcca gcatccacga caccgtggag aacctgatca tcctggccaa caacagcctg     2700

agcagcaacg gcaacgtgac cgagagcggc tgcaaggagt gcgaggagct ggaggagaag     2760

aacatcaagg agttcctgca gagcttcgtg cacatcgtgc agatgttcat caacaccagc     2820

tccggcggcg gctccggcgg cggcggctcc ggcggcggcg gctccggcgg cggcggctcc     2880

ggcggcggct ccctgcaggc ccccagaaga gccagaggct gcagaaccct gggcctgccc     2940

gccctgctgc tgctgctgct gctgagaccc cccgccacca gaggcatcac ctgccccccc     3000

cccatgagcg tggagcacgc cgacatctgg gtgaagagct acagcctgta cagcagagag     3060

agatacatct gcaacagcgg cttcaagaga aaggccggca ccagcagcct gaccgagtgc     3120

gtgctgaaca aggccaccaa cgtggcccac tggaccaccc ccagcctgaa gtgcatcaga     3180

taagtttaaa c                                                          3191


<210>  136
<211>  508
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  (CD123b-2G CAR amino acid sequence)

<400>  136

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Met Ala Asp Tyr Lys Asp Ile Val Met Thr Gln 
            20                  25                  30          


Ser His Lys Phe Met Ser Thr Ser Val Gly Asp Arg Val Asn Ile Thr 
        35                  40                  45              


Cys Lys Ala Ser Gln Asn Val Asp Ser Ala Val Ala Trp Tyr Gln Gln 
    50                  55                  60                  


Lys Pro Gly Gln Ser Pro Lys Ala Leu Ile Tyr Ser Ala Ser Tyr Arg 
65                  70                  75                  80  


Tyr Ser Gly Val Pro Asp Arg Phe Thr Gly Arg Gly Ser Gly Thr Asp 
                85                  90                  95      


Phe Thr Leu Thr Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Val Tyr 
            100                 105                 110         


Tyr Cys Gln Gln Tyr Tyr Ser Thr Pro Trp Thr Phe Gly Gly Gly Thr 
        115                 120                 125             


Lys Leu Glu Ile Lys Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Lys Leu Val Glu 
145                 150                 155                 160 


Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Ser Leu Ser Cys 
                165                 170                 175     


Ala Ala Ser Gly Phe Thr Phe Thr Asp Tyr Tyr Met Ser Trp Val Arg 
            180                 185                 190         


Gln Pro Pro Gly Lys Ala Leu Glu Trp Leu Ala Leu Ile Arg Ser Lys 
        195                 200                 205             


Ala Asp Gly Tyr Thr Thr Glu Tyr Ser Ala Ser Val Lys Gly Arg Phe 
    210                 215                 220                 


Thr Leu Ser Arg Asp Asp Ser Gln Ser Ile Leu Tyr Leu Gln Met Asn 
225                 230                 235                 240 


Ala Leu Arg Pro Glu Asp Ser Ala Thr Tyr Tyr Cys Ala Arg Asp Ala 
                245                 250                 255     


Ala Tyr Tyr Ser Tyr Tyr Ser Pro Glu Gly Ala Met Asp Tyr Trp Gly 
            260                 265                 270         


Gln Gly Thr Ser Val Thr Val Ser Ser Ala Ser Gly Ala Thr Thr Thr 
        275                 280                 285             


Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro 
    290                 295                 300                 


Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val 
305                 310                 315                 320 


His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro 
                325                 330                 335     


Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu 
            340                 345                 350         


Tyr Cys Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn 
        355                 360                 365             


Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr 
    370                 375                 380                 


Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Arg Val Lys Phe Ser 
385                 390                 395                 400 


Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr 
                405                 410                 415     


Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys 
            420                 425                 430         


Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Gln Arg Arg Lys 
        435                 440                 445             


Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala 
    450                 455                 460                 


Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys 
465                 470                 475                 480 


Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr 
                485                 490                 495     


Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            500                 505             


<210>  137
<211>  1535
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  (CD123b-2G CAR nucleotide sequence)

<400>  137
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccgatggccg actacaagga catcgtgatg acccagagcc acaagttcat gagcaccagc      120

gtgggcgaca gggtgaacat cacctgcaag gccagccaga acgtggacag cgccgtggcc      180

tggtaccagc agaagcccgg ccagagcccc aaggccctga tctacagcgc cagctacagg      240

tacagcggcg tgcccgacag gttcaccggc aggggcagcg gcaccgactt caccctgacc      300

atcagcagcg tgcaggccga ggacctggcc gtgtactact gccagcagta ctacagcacc      360

ccctggacct tcggcggcgg caccaagctg gagatcaaga ggggcggcgg cggcagcggc      420

ggcggcggca gcggcggcgg cggcagcggc ggcggcggca gcgaggtgaa gctggtggag      480

agcggcggcg gcctggtgca gcccggcggc agcctgagcc tgagctgcgc cgccagcggc      540

ttcaccttca ccgactacta catgagctgg gtgaggcagc cccccggcaa ggccctggag      600

tggctggccc tgatcaggag caaggccgac ggctacacca ccgagtacag cgccagcgtg      660

aagggcaggt tcaccctgag cagggacgac agccagagca tcctgtacct gcagatgaac      720

gccctgaggc ccgaggacag cgccacctac tactgcgcca gggacgccgc ctactacagc      780

tactacagcc ccgagggcgc catggactac tggggccagg gcaccagcgt gaccgtgagc      840

agcgccagcg gcgccaccac gacgccagcg ccgcgaccac caacaccggc gcccaccatc      900

gcgtcgcagc ccctgtccct gcgcccagag gcgtgccggc cagcggcggg gggcgcagtg      960

cacacgaggg ggctggactt cgcctgtgat atctacatct gggcgccctt ggccgggact     1020

tgtggggtcc ttctcctgtc actggttatc accctttact gcaggagtaa gaggagcagg     1080

ctcctgcaca gtgactacat gaacatgact ccccgccgcc ccgggcccac ccgcaagcat     1140

taccagccct atgccccacc acgcgacttc gcagcctatc gctccagagt gaagttcagc     1200

aggagcgcag acgcccccgc gtaccagcag ggccagaacc agctctataa cgagctcaat     1260

ctaggacgaa gagaggagta cgatgttttg gacaagagac gtggccggga ccctgagatg     1320

gggggaaagc cgcagagaag gaagaaccct caggaaggcc tgtacaatga actgcagaaa     1380

gataagatgg cggaggccta cagtgagatt gggatgaaag gcgagcgccg gaggggcaag     1440

gggcacgatg gcctttacca gggtctcagt acagccacca aggacaccta cgacgccctt     1500

cacatgcagg ccctgccccc tcgctaagtt taaac                                1535


<210>  138
<211>  1027
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  (CD123b-CD33b-2G CAR amino acid sequence)

<400>  138

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Met Ala Asp Tyr Lys Asp Ile Val Met Thr Gln 
            20                  25                  30          


Ser His Lys Phe Met Ser Thr Ser Val Gly Asp Arg Val Asn Ile Thr 
        35                  40                  45              


Cys Lys Ala Ser Gln Asn Val Asp Ser Ala Val Ala Trp Tyr Gln Gln 
    50                  55                  60                  


Lys Pro Gly Gln Ser Pro Lys Ala Leu Ile Tyr Ser Ala Ser Tyr Arg 
65                  70                  75                  80  


Tyr Ser Gly Val Pro Asp Arg Phe Thr Gly Arg Gly Ser Gly Thr Asp 
                85                  90                  95      


Phe Thr Leu Thr Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Val Tyr 
            100                 105                 110         


Tyr Cys Gln Gln Tyr Tyr Ser Thr Pro Trp Thr Phe Gly Gly Gly Thr 
        115                 120                 125             


Lys Leu Glu Ile Lys Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Lys Leu Val Glu 
145                 150                 155                 160 


Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Ser Leu Ser Cys 
                165                 170                 175     


Ala Ala Ser Gly Phe Thr Phe Thr Asp Tyr Tyr Met Ser Trp Val Arg 
            180                 185                 190         


Gln Pro Pro Gly Lys Ala Leu Glu Trp Leu Ala Leu Ile Arg Ser Lys 
        195                 200                 205             


Ala Asp Gly Tyr Thr Thr Glu Tyr Ser Ala Ser Val Lys Gly Arg Phe 
    210                 215                 220                 


Thr Leu Ser Arg Asp Asp Ser Gln Ser Ile Leu Tyr Leu Gln Met Asn 
225                 230                 235                 240 


Ala Leu Arg Pro Glu Asp Ser Ala Thr Tyr Tyr Cys Ala Arg Asp Ala 
                245                 250                 255     


Ala Tyr Tyr Ser Tyr Tyr Ser Pro Glu Gly Ala Met Asp Tyr Trp Gly 
            260                 265                 270         


Gln Gly Thr Ser Val Thr Val Ser Ser Ala Ser Gly Ala Thr Thr Thr 
        275                 280                 285             


Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro 
    290                 295                 300                 


Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val 
305                 310                 315                 320 


His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro 
                325                 330                 335     


Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu 
            340                 345                 350         


Tyr Cys Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn 
        355                 360                 365             


Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr 
    370                 375                 380                 


Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Arg Val Lys Phe Ser 
385                 390                 395                 400 


Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr 
                405                 410                 415     


Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys 
            420                 425                 430         


Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Gln Arg Arg Lys 
        435                 440                 445             


Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala 
    450                 455                 460                 


Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys 
465                 470                 475                 480 


Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr 
                485                 490                 495     


Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg Gly Ser Gly Ala 
            500                 505                 510         


Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro 
        515                 520                 525             


Gly Pro Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu 
    530                 535                 540                 


Leu Leu His Ala Ala Arg Pro Met Ala Asp Tyr Lys Asp Ile Val Met 
545                 550                 555                 560 


Thr Gln Ser His Lys Phe Leu Leu Val Ser Val Gly Asp Arg Val Ser 
                565                 570                 575     


Ile Thr Cys Lys Ala Ser Gln Asp Val Ser Thr Ala Val Ala Trp Tyr 
            580                 585                 590         


Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile Tyr Ser Ala Ser 
        595                 600                 605             


Tyr Arg Tyr Thr Gly Val Pro Asp Arg Phe Ile Gly Ser Gly Ser Gly 
    610                 615                 620                 


Thr Asp Phe Thr Leu Thr Ile Ser Ser Val Gln Ala Glu Asp Leu Ala 
625                 630                 635                 640 


Asp Tyr Phe Cys Gln Gln His Tyr Ser Thr Pro Leu Thr Phe Gly Ala 
                645                 650                 655     


Gly Thr Lys Leu Glu Ile Lys Arg Gly Gly Gly Gly Ser Gly Gly Gly 
            660                 665                 670         


Gly Ser Gly Gly Gly Gly Ser Ser Gly Gly Gly Ser Glu Val Gln Leu 
        675                 680                 685             


Lys Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln Ser Leu Ser Ile 
    690                 695                 700                 


Thr Cys Thr Val Ser Gly Phe Pro Leu Thr Ser Tyr Gly Val Ser Trp 
705                 710                 715                 720 


Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Leu Gly Val Ile Trp 
                725                 730                 735     


Gly Asp Gly Ser Thr Asn Tyr His Ser Ala Leu Ile Ser Arg Leu Ser 
            740                 745                 750         


Ile Ser Lys Asp Asn Ser Lys Ser Gln Val Phe Leu Lys Leu Asn Asn 
        755                 760                 765             


Leu Gln Thr Asp Asp Thr Ala Thr Tyr Tyr Cys Ala Arg Asp Thr Tyr 
    770                 775                 780                 


Tyr Pro Tyr Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr 
785                 790                 795                 800 


Val Ser Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro 
                805                 810                 815     


Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro 
            820                 825                 830         


Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp 
        835                 840                 845             


Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu 
    850                 855                 860                 


Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu 
865                 870                 875                 880 


Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu 
                885                 890                 895     


Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys 
            900                 905                 910         


Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln 
        915                 920                 925             


Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu 
    930                 935                 940                 


Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly 
945                 950                 955                 960 


Gly Lys Pro Gln Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu 
                965                 970                 975     


Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys 
            980                 985                 990         


Gly Glu Arg Arg Arg Gly Lys Gly  His Asp Gly Leu Tyr  Gln Gly Leu 
        995                 1000                 1005             


Ser Thr  Ala Thr Lys Asp Thr  Tyr Asp Ala Leu His  Met Gln Ala 
    1010                 1015                 1020             


Leu Pro  Pro Arg 
    1025         


<210>  139
<211>  3084
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  (CD123b-CD33b-2G CAR nucleotide sequence)

<400>  139
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccgatggccg actacaagga catcgtgatg acccagagcc acaagttcat gagcaccagc      120

gtgggcgaca gggtgaacat cacctgcaag gccagccaga acgtggacag cgccgtggcc      180

tggtaccagc agaagcccgg ccagagcccc aaggccctga tctacagcgc cagctacagg      240

tacagcggcg tgcccgacag gttcaccggc aggggcagcg gcaccgactt caccctgacc      300

atcagcagcg tgcaggccga ggacctggcc gtgtactact gccagcagta ctacagcacc      360

ccctggacct tcggcggcgg caccaagctg gagatcaaga ggggcggcgg cggcagcggc      420

ggcggcggca gcggcggcgg cggcagcggc ggcggcggca gcgaggtgaa gctggtggag      480

agcggcggcg gcctggtgca gcccggcggc agcctgagcc tgagctgcgc cgccagcggc      540

ttcaccttca ccgactacta catgagctgg gtgaggcagc cccccggcaa ggccctggag      600

tggctggccc tgatcaggag caaggccgac ggctacacca ccgagtacag cgccagcgtg      660

aagggcaggt tcaccctgag cagggacgac agccagagca tcctgtacct gcagatgaac      720

gccctgaggc ccgaggacag cgccacctac tactgcgcca gggacgccgc ctactacagc      780

tactacagcc ccgagggcgc catggactac tggggccagg gcaccagcgt gaccgtgagc      840

agcgccagcg gcgccaccac gacgccagcg ccgcgaccac caacaccggc gcccaccatc      900

gcgtcgcagc ccctgtccct gcgcccagag gcgtgccggc cagcggcggg gggcgcagtg      960

cacacgaggg ggctggactt cgcctgtgat atctacatct gggcgccctt ggccgggact     1020

tgtggggtcc ttctcctgtc actggttatc accctttact gcaggagtaa gaggagcagg     1080

ctcctgcaca gtgactacat gaacatgact ccccgccgcc ccgggcccac ccgcaagcat     1140

taccagccct atgccccacc acgcgacttc gcagcctatc gctccagagt gaagttcagc     1200

aggagcgcag acgcccccgc gtaccagcag ggccagaacc agctctataa cgagctcaat     1260

ctaggacgaa gagaggagta cgatgttttg gacaagagac gtggccggga ccctgagatg     1320

gggggaaagc cgcagagaag gaagaaccct caggaaggcc tgtacaatga actgcagaaa     1380

gataagatgg cggaggccta cagtgagatt gggatgaaag gcgagcgccg gaggggcaag     1440

gggcacgatg gcctttacca gggtctcagt acagccacca aggacaccta cgacgccctt     1500

cacatgcagg ccctgccccc tcgcggaagc ggagccacca acttcagcct gctgaagcag     1560

gccggcgacg tggaggagaa ccccggcccc atggccctgc ccgtgaccgc cctgctgctg     1620

cccctggccc tgctgctgca cgccgccagg cccatggccg actacaagga catcgtgatg     1680

acccagagcc acaagttcct gctggtgagc gtgggcgaca gggtgagcat cacctgcaag     1740

gccagccagg acgtgagcac cgccgtggcc tggtaccagc agaagcccgg ccagagcccc     1800

aagctgctga tctacagcgc cagctacagg tacaccggcg tgcccgacag gttcatcggc     1860

agcggcagcg gcaccgactt caccctgacc atcagcagcg tgcaggccga ggacctggcc     1920

gactacttct gccagcagca ctacagcacc cccctgacct tcggcgccgg caccaagctg     1980

gagatcaaga ggggcggcgg cggcagcggc ggcggcggca gcggcggcgg cggcagcagc     2040

ggcggcggca gcgaggtgca gctgaaggag agcggccccg gcctggtggc ccccagccag     2100

agcctgagca tcacctgcac cgtgagcggc ttccccctga ccagctacgg cgtgagctgg     2160

gtgaggcagc cccccggcaa gggcctggag tggctgggcg tgatctgggg cgacggcagc     2220

accaactacc acagcgccct gatcagcagg ctgagcatca gcaaggacaa cagcaagagc     2280

caggtgttcc tgaagctgaa caacctgcag accgacgaca ccgccaccta ctactgcgcc     2340

agggacacct actaccccta ctacgccatg gactactggg gccagggcac cagcgtgacc     2400

gtgagcagca ccaccacccc cgcccccagg ccccccaccc ccgcccccac catcgccagc     2460

cagcccctga gcctgaggcc cgaggcctgc aggcccgccg ccggcggcgc cgtgcacacc     2520

aggggcctgg acttcgcctg cgacatctac atctgggccc ccctggccgg cacctgcggc     2580

gtgctgctgc tgagcctggt gatcaccctg tactgcaaac ggggcagaaa gaaactcctg     2640

tatatattca aacaaccatt tatgagacca gtacaaacta ctcaagagga agatggctgt     2700

agctgccgat ttccagaaga agaagaagga ggatgtgaac tgagggtgaa gttcagcagg     2760

agcgccgacg cccccgccta ccagcagggc cagaaccagc tgtacaacga gctgaacctg     2820

ggcaggaggg aggagtacga cgtgctggac aagaggaggg gcagggaccc cgagatgggc     2880

ggcaagcccc agaggaggaa gaacccccag gagggcctgt acaacgagct gcagaaggac     2940

aagatggccg aggcctacag cgagatcggc atgaagggcg agaggaggag gggcaagggc     3000

cacgacggcc tgtaccaggg cctgagcacc gccaccaagg acacctacga cgccctgcac     3060

atgcaggccc tgccccccag gtaa                                            3084


<210>  140
<211>  763
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  (BCMA-A7D-28-4-1BBL, CD269 A7D-28-4-1BBL amino acid sequence)

<400>  140

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Asp Val Val Met Thr Gln Ser His Arg Phe Met 
            20                  25                  30          


Ser Thr Ser Val Gly Asp Arg Val Ser Ile Thr Cys Arg Ala Ser Gln 
        35                  40                  45              


Asp Val Asn Thr Ala Val Ser Trp Tyr Gln Gln Lys Pro Gly Gln Ser 
    50                  55                  60                  


Pro Lys Leu Leu Ile Phe Ser Ala Ser Tyr Arg Tyr Thr Gly Val Pro 
65                  70                  75                  80  


Asp Arg Phe Thr Gly Ser Gly Ser Gly Ala Asp Phe Thr Leu Thr Ile 
                85                  90                  95      


Ser Ser Val Gln Ala Glu Asp Leu Ala Val Tyr Tyr Cys Gln Gln His 
            100                 105                 110         


Tyr Ser Thr Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Asp Ile Lys 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln 
    130                 135                 140                 


Ile Gln Leu Val Gln Ser Gly Pro Asp Leu Lys Lys Pro Gly Glu Thr 
145                 150                 155                 160 


Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Phe Gly 
                165                 170                 175     


Met Asn Trp Val Lys Gln Ala Pro Gly Lys Gly Phe Lys Trp Met Ala 
            180                 185                 190         


Trp Ile Asn Thr Tyr Thr Gly Glu Ser Tyr Phe Ala Asp Asp Phe Lys 
        195                 200                 205             


Gly Arg Phe Ala Phe Ser Val Glu Thr Ser Ala Thr Thr Ala Tyr Leu 
    210                 215                 220                 


Gln Ile Asn Asn Leu Lys Thr Glu Asp Thr Ala Thr Tyr Phe Cys Ala 
225                 230                 235                 240 


Arg Gly Glu Ile Tyr Tyr Gly Tyr Asp Gly Gly Phe Ala Tyr Trp Gly 
                245                 250                 255     


Gln Gly Thr Leu Val Thr Val Ser Ala Thr Thr Thr Pro Ala Pro Arg 
            260                 265                 270         


Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg 
        275                 280                 285             


Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly 
    290                 295                 300                 


Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr 
305                 310                 315                 320 


Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Arg Ser 
                325                 330                 335     


Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg 
            340                 345                 350         


Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg 
        355                 360                 365             


Asp Phe Ala Ala Tyr Arg Ser Arg Val Lys Phe Ser Arg Ser Ala Asp 
    370                 375                 380                 


Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn 
385                 390                 395                 400 


Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg 
                405                 410                 415     


Asp Pro Glu Met Gly Gly Lys Pro Gln Arg Arg Lys Asn Pro Gln Glu 
            420                 425                 430         


Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser 
        435                 440                 445             


Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly 
    450                 455                 460                 


Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu 
465                 470                 475                 480 


His Met Gln Ala Leu Pro Pro Arg Gly Ser Gly Glu Gly Arg Gly Ser 
                485                 490                 495     


Leu Leu Thr Cys Gly Asp Val Glu Glu Asn Pro Gly Pro Met Glu Tyr 
            500                 505                 510         


Ala Ser Asp Ala Ser Leu Asp Pro Glu Ala Pro Trp Pro Pro Ala Pro 
        515                 520                 525             


Arg Ala Arg Ala Cys Arg Val Leu Pro Trp Ala Leu Val Ala Gly Leu 
    530                 535                 540                 


Leu Leu Leu Leu Leu Leu Ala Ala Ala Cys Ala Val Phe Leu Ala Cys 
545                 550                 555                 560 


Pro Trp Ala Val Ser Gly Ala Arg Ala Ser Pro Gly Ser Ala Ala Ser 
                565                 570                 575     


Pro Arg Leu Arg Glu Gly Pro Glu Leu Ser Pro Asp Asp Pro Ala Gly 
            580                 585                 590         


Leu Leu Asp Leu Arg Gln Gly Met Phe Ala Gln Leu Val Ala Gln Asn 
        595                 600                 605             


Val Leu Leu Ile Asp Gly Pro Leu Ser Trp Tyr Ser Asp Pro Gly Leu 
    610                 615                 620                 


Ala Gly Val Ser Leu Thr Gly Gly Leu Ser Tyr Lys Glu Asp Thr Lys 
625                 630                 635                 640 


Glu Leu Val Val Ala Lys Ala Gly Val Tyr Tyr Val Phe Phe Gln Leu 
                645                 650                 655     


Glu Leu Arg Arg Val Val Ala Gly Glu Gly Ser Gly Ser Val Ser Leu 
            660                 665                 670         


Ala Leu His Leu Gln Pro Leu Arg Ser Ala Ala Gly Ala Ala Ala Leu 
        675                 680                 685             


Ala Leu Thr Val Asp Leu Pro Pro Ala Ser Ser Glu Ala Arg Asn Ser 
    690                 695                 700                 


Ala Phe Gly Phe Gln Gly Arg Leu Leu His Leu Ser Ala Gly Gln Arg 
705                 710                 715                 720 


Leu Gly Val His Leu His Thr Glu Ala Arg Ala Arg His Ala Trp Gln 
                725                 730                 735     


Leu Thr Gln Gly Ala Thr Val Leu Gly Leu Phe Arg Val Thr Pro Glu 
            740                 745                 750         


Ile Pro Ala Gly Leu Pro Ser Pro Arg Ser Glu 
        755                 760             


<210>  141
<211>  2300
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  (BCMA-A7D-28-4-1BBL, CD269 A7D-28-4-1BBL CAR nucleotide sequence)

<400>  141
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccggacgtgg tgatgaccca gagccacagg ttcatgagca ccagcgtggg cgacagggtg      120

agcatcacct gcagggccag ccaggacgtg aacaccgccg tgagctggta ccagcagaag      180

cccggccaga gccccaagct gctgatcttc agcgccagct acaggtacac cggcgtgccc      240

gacaggttca ccggcagcgg cagcggcgcc gacttcaccc tgaccatcag cagcgtgcag      300

gccgaggacc tggccgtgta ctactgccag cagcactaca gcaccccctg gaccttcggc      360

ggcggcacca agctggacat caagggaggg gggggatccg ggggaggagg ctccggcgga      420

ggcggaagcc agatccagct ggtgcagagc ggccccgacc tgaagaagcc cggcgagacc      480

gtgaagctga gctgcaaggc cagcggctac accttcacca acttcggcat gaactgggtg      540

aagcaggccc ccggcaaggg cttcaagtgg atggcctgga tcaacaccta caccggcgag      600

agctacttcg ccgacgactt caagggcagg ttcgccttca gcgtggagac cagcgccacc      660

accgcctacc tgcagatcaa caacctgaag accgaggaca ccgccaccta cttctgcgcc      720

aggggcgaga tctactacgg ctacgacggc ggcttcgcct actggggcca gggcaccctg      780

gtgaccgtga gcgccaccac gacgccagcg ccgcgaccac caacaccggc gcccaccatc      840

gcgtcgcagc ccctgtccct gcgcccagag gcgtgccggc cagcggcggg gggcgcagtg      900

cacacgaggg ggctggactt cgcctgtgat atctacatct gggcgccctt ggccgggact      960

tgtggggtcc ttctcctgtc actggttatc accctttact gcaggagtaa gaggagcagg     1020

ctcctgcaca gtgactacat gaacatgact ccccgccgcc ccgggcccac ccgcaagcat     1080

taccagccct atgccccacc acgcgacttc gcagcctatc gctccagagt gaagttcagc     1140

aggagcgcag acgcccccgc gtaccagcag ggccagaacc agctctataa cgagctcaat     1200

ctaggacgaa gagaggagta cgatgttttg gacaagagac gtggccggga ccctgagatg     1260

gggggaaagc cgcagagaag gaagaaccct caggaaggcc tgtacaatga actgcagaaa     1320

gataagatgg cggaggccta cagtgagatt gggatgaaag gcgagcgccg gaggggcaag     1380

gggcacgatg gcctttacca gggtctcagt acagccacca aggacaccta cgacgccctt     1440

cacatgcagg ccctgccccc tcgcggcagc ggcgaaggcc gcggcagcct gctgacctgc     1500

ggcgatgtgg aagaaaaccc gggccccatg gaatacgcct ctgacgcttc actggacccc     1560

gaagccccgt ggcctcccgc gccccgcgct cgcgcctgcc gcgtactgcc ttgggccctg     1620

gtcgcggggc tgctgctgct gctgctgctc gctgccgcct gcgccgtctt cctcgcctgc     1680

ccctgggccg tgtccggggc tcgcgcctcg cccggctccg cggccagccc gagactccgc     1740

gagggtcccg agctttcgcc cgacgatccc gccggcctct tggacctgcg gcagggcatg     1800

tttgcgcagc tggtggccca aaatgttctg ctgatcgatg ggcccctgag ctggtacagt     1860

gacccaggcc tggcaggcgt gtccctgacg gggggcctga gctacaaaga ggacacgaag     1920

gagctggtgg tggccaaggc tggagtctac tatgtcttct ttcaactaga gctgcggcgc     1980

gtggtggccg gcgagggctc aggctccgtt tcacttgcgc tgcacctgca gccactgcgc     2040

tctgctgctg gggccgccgc cctggctttg accgtggacc tgccacccgc ctcctccgag     2100

gctcggaact cggccttcgg tttccagggc cgcttgctgc acctgagtgc cggccagcgc     2160

ctgggcgtcc atcttcacac tgaggccagg gcacgccatg cctggcagct tacccagggc     2220

gccacagtct tgggactctt ccgggtgacc cccgaaatcc cagccggact cccttcaccg     2280

aggtcggaat aagtttaaac                                                 2300


<210>  142
<211>  821
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  (BCMA-A7D-28-IL-15/IL-15sushi anchor, 
       CD269-A7D-28-IL-15/IL-15sushi anchor CAR amino acid sequence)

<400>  142

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Asp Val Val Met Thr Gln Ser His Arg Phe Met 
            20                  25                  30          


Ser Thr Ser Val Gly Asp Arg Val Ser Ile Thr Cys Arg Ala Ser Gln 
        35                  40                  45              


Asp Val Asn Thr Ala Val Ser Trp Tyr Gln Gln Lys Pro Gly Gln Ser 
    50                  55                  60                  


Pro Lys Leu Leu Ile Phe Ser Ala Ser Tyr Arg Tyr Thr Gly Val Pro 
65                  70                  75                  80  


Asp Arg Phe Thr Gly Ser Gly Ser Gly Ala Asp Phe Thr Leu Thr Ile 
                85                  90                  95      


Ser Ser Val Gln Ala Glu Asp Leu Ala Val Tyr Tyr Cys Gln Gln His 
            100                 105                 110         


Tyr Ser Thr Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Asp Ile Lys 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln 
    130                 135                 140                 


Ile Gln Leu Val Gln Ser Gly Pro Asp Leu Lys Lys Pro Gly Glu Thr 
145                 150                 155                 160 


Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Phe Gly 
                165                 170                 175     


Met Asn Trp Val Lys Gln Ala Pro Gly Lys Gly Phe Lys Trp Met Ala 
            180                 185                 190         


Trp Ile Asn Thr Tyr Thr Gly Glu Ser Tyr Phe Ala Asp Asp Phe Lys 
        195                 200                 205             


Gly Arg Phe Ala Phe Ser Val Glu Thr Ser Ala Thr Thr Ala Tyr Leu 
    210                 215                 220                 


Gln Ile Asn Asn Leu Lys Thr Glu Asp Thr Ala Thr Tyr Phe Cys Ala 
225                 230                 235                 240 


Arg Gly Glu Ile Tyr Tyr Gly Tyr Asp Gly Gly Phe Ala Tyr Trp Gly 
                245                 250                 255     


Gln Gly Thr Leu Val Thr Val Ser Ala Thr Thr Thr Pro Ala Pro Arg 
            260                 265                 270         


Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg 
        275                 280                 285             


Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly 
    290                 295                 300                 


Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr 
305                 310                 315                 320 


Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Arg Ser 
                325                 330                 335     


Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg 
            340                 345                 350         


Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg 
        355                 360                 365             


Asp Phe Ala Ala Tyr Arg Ser Arg Val Lys Phe Ser Arg Ser Ala Asp 
    370                 375                 380                 


Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn 
385                 390                 395                 400 


Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg 
                405                 410                 415     


Asp Pro Glu Met Gly Gly Lys Pro Gln Arg Arg Lys Asn Pro Gln Glu 
            420                 425                 430         


Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser 
        435                 440                 445             


Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly 
    450                 455                 460                 


Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu 
465                 470                 475                 480 


His Met Gln Ala Leu Pro Pro Arg Gly Ser Gly Ala Thr Asn Phe Ser 
                485                 490                 495     


Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met Tyr 
            500                 505                 510         


Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu Val Thr 
        515                 520                 525             


Asn Ser Gly Ile His Val Phe Ile Leu Gly Cys Phe Ser Ala Gly Leu 
    530                 535                 540                 


Pro Lys Thr Glu Ala Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys 
545                 550                 555                 560 


Ile Glu Asp Leu Ile Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr 
                565                 570                 575     


Glu Ser Asp Val His Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe 
            580                 585                 590         


Leu Leu Glu Leu Gln Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile 
        595                 600                 605             


His Asp Thr Val Glu Asn Leu Ile Ile Leu Ala Asn Asn Ser Leu Ser 
    610                 615                 620                 


Ser Asn Gly Asn Val Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu 
625                 630                 635                 640 


Glu Glu Lys Asn Ile Lys Glu Phe Leu Gln Ser Phe Val His Ile Val 
                645                 650                 655     


Gln Met Phe Ile Asn Thr Ser Ser Gly Gly Gly Ser Gly Gly Gly Gly 
            660                 665                 670         


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Leu 
        675                 680                 685             


Gln Ile Thr Cys Pro Pro Pro Met Ser Val Glu His Ala Asp Ile Trp 
    690                 695                 700                 


Val Lys Ser Tyr Ser Leu Tyr Ser Arg Glu Arg Tyr Ile Cys Asn Ser 
705                 710                 715                 720 


Gly Phe Lys Arg Lys Ala Gly Thr Ser Ser Leu Thr Glu Cys Val Leu 
                725                 730                 735     


Asn Lys Ala Thr Asn Val Ala His Trp Thr Thr Pro Ser Leu Lys Cys 
            740                 745                 750         


Ile Arg Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr 
        755                 760                 765             


Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala 
    770                 775                 780                 


Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Val 
785                 790                 795                 800 


Ala Ile Ser Thr Ser Thr Val Leu Leu Cys Gly Leu Ser Ala Val Ser 
                805                 810                 815     


Leu Leu Ala Cys Tyr 
            820     


<210>  143
<211>  2474
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  (BCMA-A7D-28-IL-15/IL-15sushi anchor, 
       CD269-A7D-28-IL-15/IL-15sushi anchor CAR nucleotide sequence)

<400>  143
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccggacgtgg tgatgaccca gagccacagg ttcatgagca ccagcgtggg cgacagggtg      120

agcatcacct gcagggccag ccaggacgtg aacaccgccg tgagctggta ccagcagaag      180

cccggccaga gccccaagct gctgatcttc agcgccagct acaggtacac cggcgtgccc      240

gacaggttca ccggcagcgg cagcggcgcc gacttcaccc tgaccatcag cagcgtgcag      300

gccgaggacc tggccgtgta ctactgccag cagcactaca gcaccccctg gaccttcggc      360

ggcggcacca agctggacat caagggaggg gggggatccg ggggaggagg ctccggcgga      420

ggcggaagcc agatccagct ggtgcagagc ggccccgacc tgaagaagcc cggcgagacc      480

gtgaagctga gctgcaaggc cagcggctac accttcacca acttcggcat gaactgggtg      540

aagcaggccc ccggcaaggg cttcaagtgg atggcctgga tcaacaccta caccggcgag      600

agctacttcg ccgacgactt caagggcagg ttcgccttca gcgtggagac cagcgccacc      660

accgcctacc tgcagatcaa caacctgaag accgaggaca ccgccaccta cttctgcgcc      720

aggggcgaga tctactacgg ctacgacggc ggcttcgcct actggggcca gggcaccctg      780

gtgaccgtga gcgccaccac gacgccagcg ccgcgaccac caacaccggc gcccaccatc      840

gcgtcgcagc ccctgtccct gcgcccagag gcgtgccggc cagcggcggg gggcgcagtg      900

cacacgaggg ggctggactt cgcctgtgat atctacatct gggcgccctt ggccgggact      960

tgtggggtcc ttctcctgtc actggttatc accctttact gcaggagtaa gaggagcagg     1020

ctcctgcaca gtgactacat gaacatgact ccccgccgcc ccgggcccac ccgcaagcat     1080

taccagccct atgccccacc acgcgacttc gcagcctatc gctccagagt gaagttcagc     1140

aggagcgcag acgcccccgc gtaccagcag ggccagaacc agctctataa cgagctcaat     1200

ctaggacgaa gagaggagta cgatgttttg gacaagagac gtggccggga ccctgagatg     1260

gggggaaagc cgcagagaag gaagaaccct caggaaggcc tgtacaatga actgcagaaa     1320

gataagatgg cggaggccta cagtgagatt gggatgaaag gcgagcgccg gaggggcaag     1380

gggcacgatg gcctttacca gggtctcagt acagccacca aggacaccta cgacgccctt     1440

cacatgcagg ccctgccccc tcgcggaagc ggagccacca acttcagcct gctgaagcag     1500

gccggcgacg tggaggagaa ccccggcccc atgtacagaa tgcagctgct gagctgcatc     1560

gccctgagcc tggccctggt gaccaacagc ggcatccacg tgttcatcct gggctgcttc     1620

agcgccggcc tgcccaagac cgaggccaac tgggtgaacg tgatcagcga cctgaagaag     1680

atcgaggacc tgatccagag catgcacatc gacgccaccc tgtacaccga gagcgacgtg     1740

caccccagct gcaaggtgac cgccatgaag tgcttcctgc tggagctgca ggtgatcagc     1800

ctggagagcg gcgacgccag catccacgac accgtggaga acctgatcat cctggccaac     1860

aacagcctga gcagcaacgg caacgtgacc gagagcggct gcaaggagtg cgaggagctg     1920

gaggagaaga acatcaagga gttcctgcag agcttcgtgc acatcgtgca gatgttcatc     1980

aacaccagct ccggcggcgg ctccggcggc ggcggctccg gcggcggcgg ctccggcggc     2040

ggcggctccg gcggcggctc cctgcagatc acctgccccc cccccatgag cgtggagcac     2100

gccgacatct gggtgaagag ctacagcctg tacagcagag agagatacat ctgcaacagc     2160

ggcttcaaga gaaaggccgg caccagcagc ctgaccgagt gcgtgctgaa caaggccacc     2220

aacgtggccc actggaccac ccccagcctg aagtgcatca gaaccaccac ccccgccccc     2280

aggcccccca cccccgcccc caccatcgcc agccagcccc tgagcctgag gcccgaggcc     2340

tgcaggcccg ccgccggcgg cgccgtgcac accaggggcc tggacttcgc ctgcgacgtg     2400

gctatctcca cgtccactgt cctgctgtgt gggctgagcg ctgtgtctct cctggcatgc     2460

tactaagttt aaac                                                       2474


<210>  144
<211>  491
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  (BAFFR-28-2G CAR amino acid sequence)

<400>  144

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gln Val Gln Leu Gln Gln Ser Gly Pro Gly Leu 
            20                  25                  30          


Val Lys Pro Ser Gln Thr Leu Ser Leu Ile Cys Ala Ile Ser Gly Asp 
        35                  40                  45              


Ser Val Ser Ser Asn Ser Ala Ala Trp Gly Trp Ile Arg Gln Ser Pro 
    50                  55                  60                  


Gly Arg Gly Leu Glu Trp Leu Gly Arg Ile Tyr Tyr Arg Ser Lys Trp 
65                  70                  75                  80  


Tyr Asn Ser Tyr Ala Val Ser Val Lys Ser Arg Ile Thr Ile Asn Pro 
                85                  90                  95      


Asp Thr Ser Lys Asn Gln Phe Ser Leu Gln Leu Asn Ser Val Thr Pro 
            100                 105                 110         


Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Tyr Asp Trp Val Pro Lys 
        115                 120                 125             


Ile Gly Val Phe Asp Ser Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
145                 150                 155                 160 


Asp Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
                165                 170                 175     


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Phe Ile Ser Ser Ser 
            180                 185                 190         


Tyr Leu Ser Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        195                 200                 205             


Ile Tyr Gly Ser Ser Ser Arg Ala Thr Gly Val Pro Ala Arg Phe Ser 
    210                 215                 220                 


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu 
225                 230                 235                 240 


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Leu Tyr Ser Ser Pro 
                245                 250                 255     


Met Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Thr Thr Thr Pro 
            260                 265                 270         


Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu 
        275                 280                 285             


Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His 
    290                 295                 300                 


Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu 
305                 310                 315                 320 


Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr 
                325                 330                 335     


Cys Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met 
            340                 345                 350         


Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala 
        355                 360                 365             


Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Arg Val Lys Phe Ser Arg 
    370                 375                 380                 


Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn 
385                 390                 395                 400 


Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg 
                405                 410                 415     


Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Gln Arg Arg Lys Asn 
            420                 425                 430         


Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu 
        435                 440                 445             


Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly 
    450                 455                 460                 


His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr 
465                 470                 475                 480 


Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
                485                 490     


<210>  145
<211>  1484
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  (BAFFR-28-2G CAR nucleotide sequence)

<400>  145
atggccctgc ccgtgaccgc cctgctgctg cccctggccc tgctgctgca cgccgccagg       60

ccccaggtgc agctgcagca gagcggccca ggcctggtca agccctctca gaccctgtca      120

ctgatctgcg ccatttcagg cgacagcgtg agcagcaaca gcgccgcctg gggctggatc      180

aggcagagcc ccggtagggg cctggaatgg ctgggcagga tctactacag gtccaagtgg      240

tacaacagct acgccgtgag cgtgaagagc aggatcacca tcaaccctga caccagcaag      300

aaccagttct cactgcagct caacagcgtg acccccgagg acaccgccgt gtactactgc      360

gccagatacg actgggtgcc caagatcggc gtgttcgaca gctggggcca gggcaccctg      420

gtgaccgtgt caagcggagg ggggggatcc gggggaggag gctccggcgg aggcggaagc      480

gatatcgtgc tgacacagag ccccgccacc ctgagcctga gcccaggcga gagggccacc      540

ctgtcctgca gggccagcca gtttatcagc agcagctacc tgtcctggta tcagcagaag      600

cccggccagg cccctagact gctgatctac ggcagctcct ctcgggccac cggcgtgccc      660

gccaggttca gcggcagcgg ctccggcacc gacttcaccc tgacaatcag cagcctggag      720

cccgaggact tcgccgtgta ctactgccag cagctgtaca gctcacccat gaccttcggc      780

cagggcacca aggtggagat caagaccacc acccccgccc ccaggccccc cacccccgcc      840

cccaccatcg ccagccagcc cctgagcctg aggcccgagg cctgcaggcc cgccgccggc      900

ggcgccgtgc acaccagggg cctggacttc gcctgcgaca tctacatctg ggcccccctg      960

gccggcacct gcggcgtgct gctgctgagc ctggtgatca ccctgtactg caggagtaag     1020

aggagcaggc tcctgcacag tgactacatg aacatgactc cccgccgccc cgggcccacc     1080

cgcaagcatt accagcccta tgccccacca cgcgacttcg cagcctatcg ctccagggtg     1140

aagttcagca ggagcgccga cgcccccgcc taccagcagg gccagaacca gctgtacaac     1200

gagctgaacc tgggcaggag ggaggagtac gacgtgctgg acaagaggag gggcagggac     1260

cccgagatgg gcggcaagcc ccagaggagg aagaaccccc aggagggcct gtacaacgag     1320

ctgcagaagg acaagatggc cgaggcctac agcgagatcg gcatgaaggg cgagaggagg     1380

aggggcaagg gccacgacgg cctgtaccag ggcctgagca ccgccaccaa ggacacctac     1440

gacgccctgc acatgcaggc cctgcccccc aggtaagttt aaac                      1484


<210>  146
<211>  1024
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  (CD4-CD123b-2G CAR amino acid sequence)

<400>  146

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu 
            20                  25                  30          


Ala Val Ser Leu Gly Glu Arg Val Thr Met Asn Cys Lys Ser Ser Gln 
        35                  40                  45              


Ser Leu Leu Tyr Ser Thr Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln 
    50                  55                  60                  


Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr 
65                  70                  75                  80  


Arg Glu Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr 
                85                  90                  95      


Asp Phe Thr Leu Thr Ile Ser Ser Val Gln Ala Glu Asp Val Ala Val 
            100                 105                 110         


Tyr Tyr Cys Gln Gln Tyr Tyr Ser Tyr Arg Thr Phe Gly Gly Gly Thr 
        115                 120                 125             


Lys Leu Glu Ile Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Val Val 
145                 150                 155                 160 


Lys Pro Gly Ala Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr 
                165                 170                 175     


Phe Thr Ser Tyr Val Ile His Trp Val Arg Gln Lys Pro Gly Gln Gly 
            180                 185                 190         


Leu Asp Trp Ile Gly Tyr Ile Asn Pro Tyr Asn Asp Gly Thr Asp Tyr 
        195                 200                 205             


Asp Glu Lys Phe Lys Gly Lys Ala Thr Leu Thr Ser Asp Thr Ser Thr 
    210                 215                 220                 


Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala 
225                 230                 235                 240 


Val Tyr Tyr Cys Ala Arg Glu Lys Asp Asn Tyr Ala Thr Gly Ala Trp 
                245                 250                 255     


Phe Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Thr Thr 
            260                 265                 270         


Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln 
        275                 280                 285             


Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala 
    290                 295                 300                 


Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala 
305                 310                 315                 320 


Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr 
                325                 330                 335     


Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln 
            340                 345                 350         


Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser 
        355                 360                 365             


Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys 
    370                 375                 380                 


Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln 
385                 390                 395                 400 


Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu 
                405                 410                 415     


Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Gln Arg 
            420                 425                 430         


Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys 
        435                 440                 445             


Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg 
    450                 455                 460                 


Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys 
465                 470                 475                 480 


Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg Gly Ser 
                485                 490                 495     


Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu 
            500                 505                 510         


Asn Pro Gly Pro Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu 
        515                 520                 525             


Ala Leu Leu Leu His Ala Ala Arg Pro Met Ala Asp Tyr Lys Asp Ile 
    530                 535                 540                 


Val Met Thr Gln Ser His Lys Phe Met Ser Thr Ser Val Gly Asp Arg 
545                 550                 555                 560 


Val Asn Ile Thr Cys Lys Ala Ser Gln Asn Val Asp Ser Ala Val Ala 
                565                 570                 575     


Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Ala Leu Ile Tyr Ser 
            580                 585                 590         


Ala Ser Tyr Arg Tyr Ser Gly Val Pro Asp Arg Phe Thr Gly Arg Gly 
        595                 600                 605             


Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Val Gln Ala Glu Asp 
    610                 615                 620                 


Leu Ala Val Tyr Tyr Cys Gln Gln Tyr Tyr Ser Thr Pro Trp Thr Phe 
625                 630                 635                 640 


Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Gly Gly Gly Gly Ser Gly 
                645                 650                 655     


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val 
            660                 665                 670         


Lys Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu 
        675                 680                 685             


Ser Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Thr Asp Tyr Tyr Met 
    690                 695                 700                 


Ser Trp Val Arg Gln Pro Pro Gly Lys Ala Leu Glu Trp Leu Ala Leu 
705                 710                 715                 720 


Ile Arg Ser Lys Ala Asp Gly Tyr Thr Thr Glu Tyr Ser Ala Ser Val 
                725                 730                 735     


Lys Gly Arg Phe Thr Leu Ser Arg Asp Asp Ser Gln Ser Ile Leu Tyr 
            740                 745                 750         


Leu Gln Met Asn Ala Leu Arg Pro Glu Asp Ser Ala Thr Tyr Tyr Cys 
        755                 760                 765             


Ala Arg Asp Ala Ala Tyr Tyr Ser Tyr Tyr Ser Pro Glu Gly Ala Met 
    770                 775                 780                 


Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Ala Ser Gly 
785                 790                 795                 800 


Ala Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile 
                805                 810                 815     


Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala 
            820                 825                 830         


Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr 
        835                 840                 845             


Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu 
    850                 855                 860                 


Val Ile Thr Leu Tyr Cys Arg Ser Lys Arg Ser Arg Leu Leu His Ser 
865                 870                 875                 880 


Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His 
                885                 890                 895     


Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Arg 
            900                 905                 910         


Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln 
        915                 920                 925             


Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp 
    930                 935                 940                 


Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro 
945                 950                 955                 960 


Gln Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys 
                965                 970                 975     


Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg 
            980                 985                 990         


Arg Arg Gly Lys Gly His Asp Gly  Leu Tyr Gln Gly Leu  Ser Thr Ala 
        995                 1000                 1005             


Thr Lys  Asp Thr Tyr Asp Ala  Leu His Met Gln Ala  Leu Pro Pro 
    1010                 1015                 1020             


Arg 
    


<210>  147
<211>  3083
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  (CD4-CD123b-2G CAR nucleotide sequence)

<400>  147
atggccctgc ccgtgaccgc cctgctgctg cccctggccc tgctgctgca cgccgccagg       60

cccgacatcg tgatgaccca aagccccgac agcctggccg tgagcctggg cgagagggtg      120

accatgaact gcaaaagcag ccagtccctg ctgtactcca ccaaccagaa gaactacctg      180

gcttggtatc aacagaagcc cggacagagc cccaagctgc tgatctattg ggccagcact      240

agggaaagcg gcgtgcccga taggttcagc ggcagcggga gcggcacaga cttcactctg      300

accattagca gcgtgcaggc tgaggatgtg gccgtctact actgccagca gtactacagc      360

tacaggacct ttgggggcgg aactaagctg gagatcaagg gagggggggg atccggggga      420

ggaggctccg gcggaggcgg aagccaagtg caactgcagc agagcggccc agaggtggtc      480

aaacctgggg caagcgtgaa gatgagctgc aaggctagcg gctatacctt caccagctat      540

gtgatccact gggtgaggca gaaaccagga cagggcctgg actggatcgg ctacatcaac      600

ccctacaatg acggcaccga ttatgacgaa aaattcaagg ggaaggccac cctgaccagc      660

gacaccagca caagcaccgc ctacatggag ctgtccagcc tgaggtccga ggacaccgcc      720

gtgtattact gtgccaggga gaaggacaat tacgccaccg gcgcttggtt cgcctactgg      780

ggccagggca cactggtgac agtgagcagc accacgacgc cagcgccgcg accaccaaca      840

ccggcgccca ccatcgcgtc gcagcccctg tccctgcgcc cagaggcgtg ccggccagcg      900

gcggggggcg cagtgcacac gagggggctg gacttcgcct gtgatatcta catctgggcc      960

cccctggccg gcacctgcgg cgtgctgctg ctgagcctgg tgatcaccct gtactgcaag     1020

aggggcagga agaagctgct gtacatcttc aagcagccct tcatgaggcc cgtgcagacc     1080

acccaggagg aggacggctg cagctgcagg ttccccgagg aggaggaggg cggctgcgag     1140

ctgagggtga agttcagcag gagcgccgac gcccccgcct accagcaggg ccagaaccag     1200

ctgtacaacg agctgaacct gggcaggagg gaggagtacg acgtgctgga caagaggagg     1260

ggcagggacc ccgagatggg cggcaagccc cagaggagga agaaccccca ggagggcctg     1320

tacaacgagc tgcagaagga caagatggcc gaggcctaca gcgagatcgg catgaagggc     1380

gagaggagga ggggcaaggg ccacgacggc ctgtaccagg gcctgagcac cgccaccaag     1440

gacacctacg acgccctgca catgcaggcc ctgcccccca ggggaagcgg agctactaac     1500

ttcagcctgc tgaagcaggc tggagacgtg gaggagaacc ctggacctat ggccttacca     1560

gtgaccgcct tgctcctgcc gctggccttg ctgctccacg ccgccaggcc gatggccgac     1620

tacaaggaca tcgtgatgac ccagagccac aagttcatga gcaccagcgt gggcgacagg     1680

gtgaacatca cctgcaaggc cagccagaac gtggacagcg ccgtggcctg gtaccagcag     1740

aagcccggcc agagccccaa ggccctgatc tacagcgcca gctacaggta cagcggcgtg     1800

cccgacaggt tcaccggcag gggcagcggc accgacttca ccctgaccat cagcagcgtg     1860

caggccgagg acctggccgt gtactactgc cagcagtact acagcacccc ctggaccttc     1920

ggcggcggca ccaagctgga gatcaagagg ggcggcggcg gcagcggcgg cggcggcagc     1980

ggcggcggcg gcagcggcgg cggcggcagc gaggtgaagc tggtggagag cggcggcggc     2040

ctggtgcagc ccggcggcag cctgagcctg agctgcgccg ccagcggctt caccttcacc     2100

gactactaca tgagctgggt gaggcagccc cccggcaagg ccctggagtg gctggccctg     2160

atcaggagca aggccgacgg ctacaccacc gagtacagcg ccagcgtgaa gggcaggttc     2220

accctgagca gggacgacag ccagagcatc ctgtacctgc agatgaacgc cctgaggccc     2280

gaggacagcg ccacctacta ctgcgccagg gacgccgcct actacagcta ctacagcccc     2340

gagggcgcca tggactactg gggccagggc accagcgtga ccgtgagcag cgccagcggc     2400

gccaccacga cgccagcgcc gcgaccacca acaccggcgc ccaccatcgc gtcgcagccc     2460

ctgtccctgc gcccagaggc gtgccggcca gcggcggggg gcgcagtgca cacgaggggg     2520

ctggacttcg cctgtgatat ctacatctgg gcgcccttgg ccgggacttg tggggtcctt     2580

ctcctgtcac tggttatcac cctttactgc aggagtaaga ggagcaggct cctgcacagt     2640

gactacatga acatgactcc ccgccgcccc gggcccaccc gcaagcatta ccagccctat     2700

gccccaccac gcgacttcgc agcctatcgc tccagagtga agttcagcag gagcgcagac     2760

gcccccgcgt accagcaggg ccagaaccag ctctataacg agctcaatct aggacgaaga     2820

gaggagtacg atgttttgga caagagacgt ggccgggacc ctgagatggg gggaaagccg     2880

cagagaagga agaaccctca ggaaggcctg tacaatgaac tgcagaaaga taagatggcg     2940

gaggcctaca gtgagattgg gatgaaaggc gagcgccgga ggggcaaggg gcacgatggc     3000

ctttaccagg gtctcagtac agccaccaag gacacctacg acgcccttca catgcaggcc     3060

ctgccccctc gctaagttta aac                                             3083


<210>  148
<211>  782
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  (BCMA-A7D-28-IL-15/IL-15sushi, CD269-A7D-28-IL-15/IL-15sushi CAR 
       amino acid sequence)

<400>  148

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Asp Val Val Met Thr Gln Ser His Arg Phe Met 
            20                  25                  30          


Ser Thr Ser Val Gly Asp Arg Val Ser Ile Thr Cys Arg Ala Ser Gln 
        35                  40                  45              


Asp Val Asn Thr Ala Val Ser Trp Tyr Gln Gln Lys Pro Gly Gln Ser 
    50                  55                  60                  


Pro Lys Leu Leu Ile Phe Ser Ala Ser Tyr Arg Tyr Thr Gly Val Pro 
65                  70                  75                  80  


Asp Arg Phe Thr Gly Ser Gly Ser Gly Ala Asp Phe Thr Leu Thr Ile 
                85                  90                  95      


Ser Ser Val Gln Ala Glu Asp Leu Ala Val Tyr Tyr Cys Gln Gln His 
            100                 105                 110         


Tyr Ser Thr Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Asp Ile Lys 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln 
    130                 135                 140                 


Ile Gln Leu Val Gln Ser Gly Pro Asp Leu Lys Lys Pro Gly Glu Thr 
145                 150                 155                 160 


Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Phe Gly 
                165                 170                 175     


Met Asn Trp Val Lys Gln Ala Pro Gly Lys Gly Phe Lys Trp Met Ala 
            180                 185                 190         


Trp Ile Asn Thr Tyr Thr Gly Glu Ser Tyr Phe Ala Asp Asp Phe Lys 
        195                 200                 205             


Gly Arg Phe Ala Phe Ser Val Glu Thr Ser Ala Thr Thr Ala Tyr Leu 
    210                 215                 220                 


Gln Ile Asn Asn Leu Lys Thr Glu Asp Thr Ala Thr Tyr Phe Cys Ala 
225                 230                 235                 240 


Arg Gly Glu Ile Tyr Tyr Gly Tyr Asp Gly Gly Phe Ala Tyr Trp Gly 
                245                 250                 255     


Gln Gly Thr Leu Val Thr Val Ser Ala Thr Thr Thr Pro Ala Pro Arg 
            260                 265                 270         


Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg 
        275                 280                 285             


Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly 
    290                 295                 300                 


Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr 
305                 310                 315                 320 


Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Arg Ser 
                325                 330                 335     


Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg 
            340                 345                 350         


Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg 
        355                 360                 365             


Asp Phe Ala Ala Tyr Arg Ser Arg Val Lys Phe Ser Arg Ser Ala Asp 
    370                 375                 380                 


Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn 
385                 390                 395                 400 


Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg 
                405                 410                 415     


Asp Pro Glu Met Gly Gly Lys Pro Gln Arg Arg Lys Asn Pro Gln Glu 
            420                 425                 430         


Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser 
        435                 440                 445             


Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly 
    450                 455                 460                 


Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu 
465                 470                 475                 480 


His Met Gln Ala Leu Pro Pro Arg Gly Ser Gly Glu Gly Arg Gly Ser 
                485                 490                 495     


Leu Leu Thr Cys Gly Asp Val Glu Glu Asn Pro Gly Pro Met Tyr Arg 
            500                 505                 510         


Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu Val Thr Asn 
        515                 520                 525             


Ser Gly Ile His Val Phe Ile Leu Gly Cys Phe Ser Ala Gly Leu Pro 
    530                 535                 540                 


Lys Thr Glu Ala Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys Ile 
545                 550                 555                 560 


Glu Asp Leu Ile Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr Glu 
                565                 570                 575     


Ser Asp Val His Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe Leu 
            580                 585                 590         


Leu Glu Leu Gln Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile His 
        595                 600                 605             


Asp Thr Val Glu Asn Leu Ile Ile Leu Ala Asn Asn Ser Leu Ser Ser 
    610                 615                 620                 


Asn Gly Asn Val Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu 
625                 630                 635                 640 


Glu Lys Asn Ile Lys Glu Phe Leu Gln Ser Phe Val His Ile Val Gln 
                645                 650                 655     


Met Phe Ile Asn Thr Ser Ser Gly Gly Gly Ser Gly Gly Gly Gly Ser 
            660                 665                 670         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Leu Gln 
        675                 680                 685             


Ala Pro Arg Arg Ala Arg Gly Cys Arg Thr Leu Gly Leu Pro Ala Leu 
    690                 695                 700                 


Leu Leu Leu Leu Leu Leu Arg Pro Pro Ala Thr Arg Gly Ile Thr Cys 
705                 710                 715                 720 


Pro Pro Pro Met Ser Val Glu His Ala Asp Ile Trp Val Lys Ser Tyr 
                725                 730                 735     


Ser Leu Tyr Ser Arg Glu Arg Tyr Ile Cys Asn Ser Gly Phe Lys Arg 
            740                 745                 750         


Lys Ala Gly Thr Ser Ser Leu Thr Glu Cys Val Leu Asn Lys Ala Thr 
        755                 760                 765             


Asn Val Ala His Trp Thr Thr Pro Ser Leu Lys Cys Ile Arg 
    770                 775                 780         


<210>  149
<211>  2357
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  (BCMA-A7D-28-IL-15/IL-15sushi, CD269-A7D-28-IL-15/IL-15sushi CAR 
       nucleotide sequence)

<400>  149
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccggacgtgg tgatgaccca gagccacagg ttcatgagca ccagcgtggg cgacagggtg      120

agcatcacct gcagggccag ccaggacgtg aacaccgccg tgagctggta ccagcagaag      180

cccggccaga gccccaagct gctgatcttc agcgccagct acaggtacac cggcgtgccc      240

gacaggttca ccggcagcgg cagcggcgcc gacttcaccc tgaccatcag cagcgtgcag      300

gccgaggacc tggccgtgta ctactgccag cagcactaca gcaccccctg gaccttcggc      360

ggcggcacca agctggacat caagggaggg gggggatccg ggggaggagg ctccggcgga      420

ggcggaagcc agatccagct ggtgcagagc ggccccgacc tgaagaagcc cggcgagacc      480

gtgaagctga gctgcaaggc cagcggctac accttcacca acttcggcat gaactgggtg      540

aagcaggccc ccggcaaggg cttcaagtgg atggcctgga tcaacaccta caccggcgag      600

agctacttcg ccgacgactt caagggcagg ttcgccttca gcgtggagac cagcgccacc      660

accgcctacc tgcagatcaa caacctgaag accgaggaca ccgccaccta cttctgcgcc      720

aggggcgaga tctactacgg ctacgacggc ggcttcgcct actggggcca gggcaccctg      780

gtgaccgtga gcgccaccac gacgccagcg ccgcgaccac caacaccggc gcccaccatc      840

gcgtcgcagc ccctgtccct gcgcccagag gcgtgccggc cagcggcggg gggcgcagtg      900

cacacgaggg ggctggactt cgcctgtgat atctacatct gggcgccctt ggccgggact      960

tgtggggtcc ttctcctgtc actggttatc accctttact gcaggagtaa gaggagcagg     1020

ctcctgcaca gtgactacat gaacatgact ccccgccgcc ccgggcccac ccgcaagcat     1080

taccagccct atgccccacc acgcgacttc gcagcctatc gctccagagt gaagttcagc     1140

aggagcgcag acgcccccgc gtaccagcag ggccagaacc agctctataa cgagctcaat     1200

ctaggacgaa gagaggagta cgatgttttg gacaagagac gtggccggga ccctgagatg     1260

gggggaaagc cgcagagaag gaagaaccct caggaaggcc tgtacaatga actgcagaaa     1320

gataagatgg cggaggccta cagtgagatt gggatgaaag gcgagcgccg gaggggcaag     1380

gggcacgatg gcctttacca gggtctcagt acagccacca aggacaccta cgacgccctt     1440

cacatgcagg ccctgccccc tcgcggcagc ggcgaaggcc gcggcagcct gctgacctgc     1500

ggcgatgtgg aagaaaaccc gggccccatg tacagaatgc agctgctgag ctgcatcgcc     1560

ctgagcctgg ccctggtgac caacagcggc atccacgtgt tcatcctggg ctgcttcagc     1620

gccggcctgc ccaagaccga ggccaactgg gtgaacgtga tcagcgacct gaagaagatc     1680

gaggacctga tccagagcat gcacatcgac gccaccctgt acaccgagag cgacgtgcac     1740

cccagctgca aggtgaccgc catgaagtgc ttcctgctgg agctgcaggt gatcagcctg     1800

gagagcggcg acgccagcat ccacgacacc gtggagaacc tgatcatcct ggccaacaac     1860

agcctgagca gcaacggcaa cgtgaccgag agcggctgca aggagtgcga ggagctggag     1920

gagaagaaca tcaaggagtt cctgcagagc ttcgtgcaca tcgtgcagat gttcatcaac     1980

accagctccg gcggcggctc cggcggcggc ggctccggcg gcggcggctc cggcggcggc     2040

ggctccggcg gcggctccct gcaggccccc agaagagcca gaggctgcag aaccctgggc     2100

ctgcccgccc tgctgctgct gctgctgctg agaccccccg ccaccagagg catcacctgc     2160

ccccccccca tgagcgtgga gcacgccgac atctgggtga agagctacag cctgtacagc     2220

agagagagat acatctgcaa cagcggcttc aagagaaagg ccggcaccag cagcctgacc     2280

gagtgcgtgc tgaacaaggc caccaacgtg gcccactgga ccacccccag cctgaagtgc     2340

atcagataag tttaaac                                                    2357


<210>  150
<211>  492
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  (CLL-1-3233-28-2G CAR amino acid sequence)

<400>  150

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu 
            20                  25                  30          


Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln 
        35                  40                  45              


Ser Val Ser Thr Ser Ser Tyr Asn Tyr Met His Trp Tyr Gln Gln Lys 
    50                  55                  60                  


Pro Gly Lys Pro Pro Lys Leu Leu Ile Lys Tyr Ala Ser Asn Leu Glu 
65                  70                  75                  80  


Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 
                85                  90                  95      


Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr 
            100                 105                 110         


Cys Gln His Ser Trp Glu Ile Pro Leu Thr Phe Gly Gln Gly Thr Lys 
        115                 120                 125             


Val Glu Ile Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys 
145                 150                 155                 160 


Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe 
                165                 170                 175     


Thr Asp Tyr Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu 
            180                 185                 190         


Glu Trp Ile Gly Arg Ile Asn Pro Tyr Asn Gly Ala Ala Phe Tyr Ser 
        195                 200                 205             


Gln Asn Phe Lys Asp Arg Val Thr Leu Thr Val Asp Thr Ser Thr Ser 
    210                 215                 220                 


Thr Ala Tyr Leu Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val 
225                 230                 235                 240 


Tyr Tyr Cys Ala Ile Glu Arg Gly Ala Asp Leu Glu Gly Tyr Ala Met 
                245                 250                 255     


Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Thr Thr Thr 
            260                 265                 270         


Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro 
        275                 280                 285             


Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val 
    290                 295                 300                 


His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro 
305                 310                 315                 320 


Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu 
                325                 330                 335     


Tyr Cys Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn 
            340                 345                 350         


Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr 
        355                 360                 365             


Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Arg Val Lys Phe Ser 
    370                 375                 380                 


Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr 
385                 390                 395                 400 


Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys 
                405                 410                 415     


Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Gln Arg Arg Lys 
            420                 425                 430         


Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala 
        435                 440                 445             


Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys 
    450                 455                 460                 


Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr 
465                 470                 475                 480 


Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
                485                 490         


<210>  151
<211>  1487
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  (CLL-1-3233-28-2G CAR nucleotide sequence)

<400>  151
atggccctgc ccgtgaccgc cctgctgctg cccctggccc tgctgctgca cgccgccagg       60

cccgacatcc agatgaccca gagccccagc agcctgagcg ccagcgtggg cgacagggtg      120

accatcacct gcagggccag ccagagcgtg agcaccagca gctacaacta catgcactgg      180

taccagcaga agcccggcaa gccccccaag ctgctgatca agtacgccag caacctggag      240

agcggcgtgc ccagcaggtt cagcggcagc ggcagcggca ccgacttcac cctgaccatc      300

agcagcctgc agcccgagga cttcgccacc tactactgcc agcacagctg ggagatcccc      360

ctgaccttcg gccagggcac caaggtggag atcaagggag gggggggatc cgggggagga      420

ggctccggcg gaggcggaag cgaggtgcag ctggtgcaga gcggcgccga ggtgaagaag      480

cccggcgcca gcgtgaaggt gagctgcaag gccagcggct acagcttcac cgactactac      540

atgcactggg tgaggcaggc ccccggccag ggcctggagt ggatcggcag gatcaacccc      600

tacaacggcg ccgccttcta cagccagaac ttcaaggaca gggtgaccct gaccgtggac      660

accagcacca gcaccgccta cctggagctg agcagcctga ggagcgagga caccgccgtg      720

tactactgcg ccatcgagag gggcgccgac ctggagggct acgccatgga ctactggggc      780

cagggcaccc tggtgaccgt gagcagcacc accacccccg cccccaggcc ccccaccccc      840

gcccccacca tcgccagcca gcccctgagc ctgaggcccg aggcctgcag gcccgccgcc      900

ggcggcgccg tgcacaccag gggcctggac ttcgcctgcg acatctacat ctgggccccc      960

ctggccggca cctgcggcgt gctgctgctg agcctggtga tcaccctgta ctgcaggagt     1020

aagaggagca ggctcctgca cagtgactac atgaacatga ctccccgccg ccccgggccc     1080

acccgcaagc attaccagcc ctatgcccca ccacgcgact tcgcagccta tcgctccagg     1140

gtgaagttca gcaggagcgc cgacgccccc gcctaccagc agggccagaa ccagctgtac     1200

aacgagctga acctgggcag gagggaggag tacgacgtgc tggacaagag gaggggcagg     1260

gaccccgaga tgggcggcaa gccccagagg aggaagaacc cccaggaggg cctgtacaac     1320

gagctgcaga aggacaagat ggccgaggcc tacagcgaga tcggcatgaa gggcgagagg     1380

aggaggggca agggccacga cggcctgtac cagggcctga gcaccgccac caaggacacc     1440

tacgacgccc tgcacatgca ggccctgccc cccaggtaag tttaaac                   1487


<210>  152
<211>  486
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  (CLL-1-3738-28-2G CAR amino acid sequence)

<400>  152

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Asp Ile Gln Met Thr Gln Ser His Lys Phe Met 
            20                  25                  30          


Ser Thr Ser Val Gly Asp Arg Val Ser Ile Thr Cys Lys Ala Ser Gln 
        35                  40                  45              


Asp Val Ser Thr Ala Val Ala Trp Phe Gln Gln Lys Pro Gly Gln Ser 
    50                  55                  60                  


Pro Lys Leu Leu Ile Tyr Ser Pro Ser Tyr Arg Tyr Thr Gly Val Pro 
65                  70                  75                  80  


Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile 
                85                  90                  95      


Ser Ser Val Gln Ala Glu Asp Leu Ala Val Tyr Tyr Cys Gln Gln Leu 
            100                 105                 110         


Tyr Ser Thr Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu 
    130                 135                 140                 


Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala Ser 
145                 150                 155                 160 


Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr Tyr 
                165                 170                 175     


Leu Asp Trp Val Lys Gln Ser His Gly Glu Ser Phe Glu Trp Ile Gly 
            180                 185                 190         


Arg Val Asn Pro Tyr Asn Gly Gly Thr Ile Tyr Asn Gln Lys Phe Lys 
        195                 200                 205             


Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr Met 
    210                 215                 220                 


Asp Leu Asn Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys Ala 
225                 230                 235                 240 


Arg Asp His Tyr Arg Tyr Asp Pro Leu Leu Asp Tyr Trp Gly Gln Gly 
                245                 250                 255     


Thr Thr Leu Thr Val Ser Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro 
            260                 265                 270         


Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu 
        275                 280                 285             


Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp 
    290                 295                 300                 


Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly 
305                 310                 315                 320 


Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Arg Ser Lys Arg 
                325                 330                 335     


Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro 
            340                 345                 350         


Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe 
        355                 360                 365             


Ala Ala Tyr Arg Ser Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro 
    370                 375                 380                 


Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly 
385                 390                 395                 400 


Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro 
                405                 410                 415     


Glu Met Gly Gly Lys Pro Gln Arg Arg Lys Asn Pro Gln Glu Gly Leu 
            420                 425                 430         


Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile 
        435                 440                 445             


Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr 
    450                 455                 460                 


Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met 
465                 470                 475                 480 


Gln Ala Leu Pro Pro Arg 
                485     


<210>  153
<211>  1469
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  (CLL-1-3738-28-2G CAR nucleotide sequence)

<400>  153
atggccctgc ccgtgaccgc cctgctgctg cccctggccc tgctgctgca cgccgccagg       60

cccgacatcc agatgaccca gagccacaag ttcatgagca ccagcgtggg cgacagggtg      120

agcatcacct gcaaggccag ccaggacgtg agcaccgccg tggcctggtt ccagcagaag      180

cccggccaga gccccaagct gctgatctac agccccagct acaggtacac cggcgtgccc      240

gacaggttca ccggcagcgg cagcggcacc gacttcacct tcaccatcag cagcgtgcag      300

gccgaggacc tggccgtgta ctactgccag cagctgtaca gcacccccta caccttcggc      360

ggcggcacca agctggagat caagggaggg gggggatccg ggggaggagg ctccggcgga      420

ggcggaagcg aggtgcagct gcagcagagc ggccccgagc tggtgaagcc cggcgccagc      480

gtgaagatga gctgcaaggc cagcggctac accttcaccg actactacct ggactgggtg      540

aagcagagcc acggcgagag cttcgagtgg atcggcaggg tgaaccccta caacggcggc      600

accatctaca accagaagtt caagggcaag gccaccctga ccgtggacaa gagcagcagc      660

accgcctaca tggacctgaa cagcctgacc agcgaggaca gcgccgtgta ctactgcgcc      720

agggaccact acaggtacga ccccctgctg gactactggg gccagggcac caccctgacc      780

gtgagcagca ccaccacccc cgcccccagg ccccccaccc ccgcccccac catcgccagc      840

cagcccctga gcctgaggcc cgaggcctgc aggcccgccg ccggcggcgc cgtgcacacc      900

aggggcctgg acttcgcctg cgacatctac atctgggccc ccctggccgg cacctgcggc      960

gtgctgctgc tgagcctggt gatcaccctg tactgcagga gtaagaggag caggctcctg     1020

cacagtgact acatgaacat gactccccgc cgccccgggc ccacccgcaa gcattaccag     1080

ccctatgccc caccacgcga cttcgcagcc tatcgctcca gggtgaagtt cagcaggagc     1140

gccgacgccc ccgcctacca gcagggccag aaccagctgt acaacgagct gaacctgggc     1200

aggagggagg agtacgacgt gctggacaag aggaggggca gggaccccga gatgggcggc     1260

aagccccaga ggaggaagaa cccccaggag ggcctgtaca acgagctgca gaaggacaag     1320

atggccgagg cctacagcga gatcggcatg aagggcgaga ggaggagggg caagggccac     1380

gacggcctgt accagggcct gagcaccgcc accaaggaca cctacgacgc cctgcacatg     1440

caggccctgc cccccaggta agtttaaac                                       1469


<210>  154
<211>  1011
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  (CLL-1-3233-CD33b-2G CAR amino acid sequence)

<400>  154

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu 
            20                  25                  30          


Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln 
        35                  40                  45              


Ser Val Ser Thr Ser Ser Tyr Asn Tyr Met His Trp Tyr Gln Gln Lys 
    50                  55                  60                  


Pro Gly Lys Pro Pro Lys Leu Leu Ile Lys Tyr Ala Ser Asn Leu Glu 
65                  70                  75                  80  


Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 
                85                  90                  95      


Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr 
            100                 105                 110         


Cys Gln His Ser Trp Glu Ile Pro Leu Thr Phe Gly Gln Gly Thr Lys 
        115                 120                 125             


Val Glu Ile Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys 
145                 150                 155                 160 


Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe 
                165                 170                 175     


Thr Asp Tyr Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu 
            180                 185                 190         


Glu Trp Ile Gly Arg Ile Asn Pro Tyr Asn Gly Ala Ala Phe Tyr Ser 
        195                 200                 205             


Gln Asn Phe Lys Asp Arg Val Thr Leu Thr Val Asp Thr Ser Thr Ser 
    210                 215                 220                 


Thr Ala Tyr Leu Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val 
225                 230                 235                 240 


Tyr Tyr Cys Ala Ile Glu Arg Gly Ala Asp Leu Glu Gly Tyr Ala Met 
                245                 250                 255     


Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Thr Thr Thr 
            260                 265                 270         


Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro 
        275                 280                 285             


Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val 
    290                 295                 300                 


His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro 
305                 310                 315                 320 


Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu 
                325                 330                 335     


Tyr Cys Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn 
            340                 345                 350         


Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr 
        355                 360                 365             


Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Arg Val Lys Phe Ser 
    370                 375                 380                 


Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr 
385                 390                 395                 400 


Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys 
                405                 410                 415     


Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Gln Arg Arg Lys 
            420                 425                 430         


Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala 
        435                 440                 445             


Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys 
    450                 455                 460                 


Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr 
465                 470                 475                 480 


Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg Gly Ser Gly Ala 
                485                 490                 495     


Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro 
            500                 505                 510         


Gly Pro Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu 
        515                 520                 525             


Leu Leu His Ala Ala Arg Pro Met Ala Asp Tyr Lys Asp Ile Val Met 
    530                 535                 540                 


Thr Gln Ser His Lys Phe Leu Leu Val Ser Val Gly Asp Arg Val Ser 
545                 550                 555                 560 


Ile Thr Cys Lys Ala Ser Gln Asp Val Ser Thr Ala Val Ala Trp Tyr 
                565                 570                 575     


Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile Tyr Ser Ala Ser 
            580                 585                 590         


Tyr Arg Tyr Thr Gly Val Pro Asp Arg Phe Ile Gly Ser Gly Ser Gly 
        595                 600                 605             


Thr Asp Phe Thr Leu Thr Ile Ser Ser Val Gln Ala Glu Asp Leu Ala 
    610                 615                 620                 


Asp Tyr Phe Cys Gln Gln His Tyr Ser Thr Pro Leu Thr Phe Gly Ala 
625                 630                 635                 640 


Gly Thr Lys Leu Glu Ile Lys Arg Gly Gly Gly Gly Ser Gly Gly Gly 
                645                 650                 655     


Gly Ser Gly Gly Gly Gly Ser Ser Gly Gly Gly Ser Glu Val Gln Leu 
            660                 665                 670         


Lys Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln Ser Leu Ser Ile 
        675                 680                 685             


Thr Cys Thr Val Ser Gly Phe Pro Leu Thr Ser Tyr Gly Val Ser Trp 
    690                 695                 700                 


Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Leu Gly Val Ile Trp 
705                 710                 715                 720 


Gly Asp Gly Ser Thr Asn Tyr His Ser Ala Leu Ile Ser Arg Leu Ser 
                725                 730                 735     


Ile Ser Lys Asp Asn Ser Lys Ser Gln Val Phe Leu Lys Leu Asn Asn 
            740                 745                 750         


Leu Gln Thr Asp Asp Thr Ala Thr Tyr Tyr Cys Ala Arg Asp Thr Tyr 
        755                 760                 765             


Tyr Pro Tyr Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr 
    770                 775                 780                 


Val Ser Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro 
785                 790                 795                 800 


Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro 
                805                 810                 815     


Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp 
            820                 825                 830         


Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu 
        835                 840                 845             


Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu 
    850                 855                 860                 


Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu 
865                 870                 875                 880 


Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys 
                885                 890                 895     


Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln 
            900                 905                 910         


Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu 
        915                 920                 925             


Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly 
    930                 935                 940                 


Gly Lys Pro Gln Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu 
945                 950                 955                 960 


Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys 
                965                 970                 975     


Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu 
            980                 985                 990         


Ser Thr Ala Thr Lys Asp Thr Tyr  Asp Ala Leu His Met  Gln Ala Leu 
        995                 1000                 1005             


Pro Pro  Arg 
    1010     


<210>  155
<211>  3044
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  (CLL-1-3233-CD33b-2G CAR nucleotide sequence)

<400>  155
atggccctgc ccgtgaccgc cctgctgctg cccctggccc tgctgctgca cgccgccagg       60

cccgacatcc agatgaccca gagccccagc agcctgagcg ccagcgtggg cgacagggtg      120

accatcacct gcagggccag ccagagcgtg agcaccagca gctacaacta catgcactgg      180

taccagcaga agcccggcaa gccccccaag ctgctgatca agtacgccag caacctggag      240

agcggcgtgc ccagcaggtt cagcggcagc ggcagcggca ccgacttcac cctgaccatc      300

agcagcctgc agcccgagga cttcgccacc tactactgcc agcacagctg ggagatcccc      360

ctgaccttcg gccagggcac caaggtggag atcaagggag gggggggatc cgggggagga      420

ggctccggcg gaggcggaag cgaggtgcag ctggtgcaga gcggcgccga ggtgaagaag      480

cccggcgcca gcgtgaaggt gagctgcaag gccagcggct acagcttcac cgactactac      540

atgcactggg tgaggcaggc ccccggccag ggcctggagt ggatcggcag gatcaacccc      600

tacaacggcg ccgccttcta cagccagaac ttcaaggaca gggtgaccct gaccgtggac      660

accagcacca gcaccgccta cctggagctg agcagcctga ggagcgagga caccgccgtg      720

tactactgcg ccatcgagag gggcgccgac ctggagggct acgccatgga ctactggggc      780

cagggcaccc tggtgaccgt gagcagcacc acgacgccag cgccgcgacc accaacaccg      840

gcgcccacca tcgcgtcgca gcccctgtcc ctgcgcccag aggcgtgccg gccagcggcg      900

gggggcgcag tgcacacgag ggggctggac ttcgcctgtg atatctacat ctgggccccc      960

ctggccggca cctgcggcgt gctgctgctg agcctggtga tcaccctgta ctgcaggagt     1020

aagaggagca ggctcctgca cagtgactac atgaacatga ctccccgccg ccccgggccc     1080

acccgcaagc attaccagcc ctatgcccca ccacgcgact tcgcagccta tcgctccagg     1140

gtgaagttca gcaggagcgc cgacgccccc gcctaccagc agggccagaa ccagctgtac     1200

aacgagctga acctgggcag gagggaggag tacgacgtgc tggacaagag gaggggcagg     1260

gaccccgaga tgggcggcaa gccccagagg aggaagaacc cccaggaggg cctgtacaac     1320

gagctgcaga aggacaagat ggccgaggcc tacagcgaga tcggcatgaa gggcgagagg     1380

aggaggggca agggccacga cggcctgtac cagggcctga gcaccgccac caaggacacc     1440

tacgacgccc tgcacatgca ggccctgccc cccaggggaa gcggagccac caacttcagc     1500

ctgctgaagc aggccggcga cgtggaggag aaccccggcc ccatggccct gcccgtgacc     1560

gccctgctgc tgcccctggc cctgctgctg cacgccgcca ggcccatggc cgactacaag     1620

gacatcgtga tgacccagag ccacaagttc ctgctggtga gcgtgggcga cagggtgagc     1680

atcacctgca aggccagcca ggacgtgagc accgccgtgg cctggtacca gcagaagccc     1740

ggccagagcc ccaagctgct gatctacagc gccagctaca ggtacaccgg cgtgcccgac     1800

aggttcatcg gcagcggcag cggcaccgac ttcaccctga ccatcagcag cgtgcaggcc     1860

gaggacctgg ccgactactt ctgccagcag cactacagca cccccctgac cttcggcgcc     1920

ggcaccaagc tggagatcaa gaggggcggc ggcggcagcg gcggcggcgg cagcggcggc     1980

ggcggcagca gcggcggcgg cagcgaggtg cagctgaagg agagcggccc cggcctggtg     2040

gcccccagcc agagcctgag catcacctgc accgtgagcg gcttccccct gaccagctac     2100

ggcgtgagct gggtgaggca gccccccggc aagggcctgg agtggctggg cgtgatctgg     2160

ggcgacggca gcaccaacta ccacagcgcc ctgatcagca ggctgagcat cagcaaggac     2220

aacagcaaga gccaggtgtt cctgaagctg aacaacctgc agaccgacga caccgccacc     2280

tactactgcg ccagggacac ctactacccc tactacgcca tggactactg gggccagggc     2340

accagcgtga ccgtgagcag caccaccacc cccgccccca ggccccccac ccccgccccc     2400

accatcgcca gccagcccct gagcctgagg cccgaggcct gcaggcccgc cgccggcggc     2460

gccgtgcaca ccaggggcct ggacttcgcc tgcgacatct acatctgggc ccccctggcc     2520

ggcacctgcg gcgtgctgct gctgagcctg gtgatcaccc tgtactgcaa acggggcaga     2580

aagaaactcc tgtatatatt caaacaacca tttatgagac cagtacaaac tactcaagag     2640

gaagatggct gtagctgccg atttccagaa gaagaagaag gaggatgtga actgagggtg     2700

aagttcagca ggagcgccga cgcccccgcc taccagcagg gccagaacca gctgtacaac     2760

gagctgaacc tgggcaggag ggaggagtac gacgtgctgg acaagaggag gggcagggac     2820

cccgagatgg gcggcaagcc ccagaggagg aagaaccccc aggagggcct gtacaacgag     2880

ctgcagaagg acaagatggc cgaggcctac agcgagatcg gcatgaaggg cgagaggagg     2940

aggggcaagg gccacgacgg cctgtaccag ggcctgagca ccgccaccaa ggacacctac     3000

gacgccctgc acatgcaggc cctgcccccc aggtaagttt aaac                      3044


<210>  156
<211>  1011
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  (CLL-1-3738-CD33b-2G CAR amino acid sequence)

<400>  156

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu 
            20                  25                  30          


Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln 
        35                  40                  45              


Ser Val Ser Thr Ser Ser Tyr Asn Tyr Met His Trp Tyr Gln Gln Lys 
    50                  55                  60                  


Pro Gly Lys Pro Pro Lys Leu Leu Ile Lys Tyr Ala Ser Asn Leu Glu 
65                  70                  75                  80  


Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 
                85                  90                  95      


Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr 
            100                 105                 110         


Cys Gln His Ser Trp Glu Ile Pro Leu Thr Phe Gly Gln Gly Thr Lys 
        115                 120                 125             


Val Glu Ile Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys 
145                 150                 155                 160 


Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe 
                165                 170                 175     


Thr Asp Tyr Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu 
            180                 185                 190         


Glu Trp Ile Gly Arg Ile Asn Pro Tyr Asn Gly Ala Ala Phe Tyr Ser 
        195                 200                 205             


Gln Asn Phe Lys Asp Arg Val Thr Leu Thr Val Asp Thr Ser Thr Ser 
    210                 215                 220                 


Thr Ala Tyr Leu Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val 
225                 230                 235                 240 


Tyr Tyr Cys Ala Ile Glu Arg Gly Ala Asp Leu Glu Gly Tyr Ala Met 
                245                 250                 255     


Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Thr Thr Thr 
            260                 265                 270         


Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro 
        275                 280                 285             


Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val 
    290                 295                 300                 


His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro 
305                 310                 315                 320 


Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu 
                325                 330                 335     


Tyr Cys Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn 
            340                 345                 350         


Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr 
        355                 360                 365             


Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Arg Val Lys Phe Ser 
    370                 375                 380                 


Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr 
385                 390                 395                 400 


Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys 
                405                 410                 415     


Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Gln Arg Arg Lys 
            420                 425                 430         


Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala 
        435                 440                 445             


Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys 
    450                 455                 460                 


Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr 
465                 470                 475                 480 


Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg Gly Ser Gly Ala 
                485                 490                 495     


Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro 
            500                 505                 510         


Gly Pro Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu 
        515                 520                 525             


Leu Leu His Ala Ala Arg Pro Met Ala Asp Tyr Lys Asp Ile Val Met 
    530                 535                 540                 


Thr Gln Ser His Lys Phe Leu Leu Val Ser Val Gly Asp Arg Val Ser 
545                 550                 555                 560 


Ile Thr Cys Lys Ala Ser Gln Asp Val Ser Thr Ala Val Ala Trp Tyr 
                565                 570                 575     


Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile Tyr Ser Ala Ser 
            580                 585                 590         


Tyr Arg Tyr Thr Gly Val Pro Asp Arg Phe Ile Gly Ser Gly Ser Gly 
        595                 600                 605             


Thr Asp Phe Thr Leu Thr Ile Ser Ser Val Gln Ala Glu Asp Leu Ala 
    610                 615                 620                 


Asp Tyr Phe Cys Gln Gln His Tyr Ser Thr Pro Leu Thr Phe Gly Ala 
625                 630                 635                 640 


Gly Thr Lys Leu Glu Ile Lys Arg Gly Gly Gly Gly Ser Gly Gly Gly 
                645                 650                 655     


Gly Ser Gly Gly Gly Gly Ser Ser Gly Gly Gly Ser Glu Val Gln Leu 
            660                 665                 670         


Lys Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln Ser Leu Ser Ile 
        675                 680                 685             


Thr Cys Thr Val Ser Gly Phe Pro Leu Thr Ser Tyr Gly Val Ser Trp 
    690                 695                 700                 


Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Leu Gly Val Ile Trp 
705                 710                 715                 720 


Gly Asp Gly Ser Thr Asn Tyr His Ser Ala Leu Ile Ser Arg Leu Ser 
                725                 730                 735     


Ile Ser Lys Asp Asn Ser Lys Ser Gln Val Phe Leu Lys Leu Asn Asn 
            740                 745                 750         


Leu Gln Thr Asp Asp Thr Ala Thr Tyr Tyr Cys Ala Arg Asp Thr Tyr 
        755                 760                 765             


Tyr Pro Tyr Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr 
    770                 775                 780                 


Val Ser Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro 
785                 790                 795                 800 


Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro 
                805                 810                 815     


Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp 
            820                 825                 830         


Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu 
        835                 840                 845             


Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu 
    850                 855                 860                 


Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu 
865                 870                 875                 880 


Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys 
                885                 890                 895     


Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln 
            900                 905                 910         


Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu 
        915                 920                 925             


Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly 
    930                 935                 940                 


Gly Lys Pro Gln Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu 
945                 950                 955                 960 


Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys 
                965                 970                 975     


Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu 
            980                 985                 990         


Ser Thr Ala Thr Lys Asp Thr Tyr  Asp Ala Leu His Met  Gln Ala Leu 
        995                 1000                 1005             


Pro Pro  Arg 
    1010     


<210>  157
<211>  2999
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  (CLL-1-3738-CD33b-2G CAR nucleotide sequence)

<400>  157
agtgaccgcc ttgctcctgc cgctggcctt gctgctccac gccgccaggc cgcagatcgt       60

gctgacccag agccccgcca tcatgagcgc cagccccggc gagaaggtga ccatcacctg      120

cagcgccagc agcagcatca gctacatgca ctggttccag cagaagcccg gcaccagccc      180

caagctgtgg atctacacca ccagcaacct ggccagcggc gtgcccgcca gattcagcgg      240

cagcggcagc ggcaccagct acagcctgac catcagcaga atggaggccg aggacgccgc      300

cacctactac tgccaccaga gaagcaccta ccccctgacc ttcggcagcg gcaccaagct      360

ggagctgaag ggaggggggg gatccggggg aggaggctcc ggcggaggcg gaagccaggt      420

gcagctgcag cagagcggcg ccgagctggc caagcccggc gccagcgtga agatgagctg      480

caaggccagc ggctacacct tcaccagcta cagaatgcac tgggtgaagc agagacccgg      540

ccagggcctg gagtggatcg gctacatcaa ccccagcacc ggctacaccg agtacaacca      600

gaagttcaag gacaaggcca ccctgaccgc cgacaagagc agcagcaccg cctacatgca      660

gctgagcagc ctgaccttcg aggacagcgc cgtgtactac tgcgccagag gcggcggcgt      720

gttcgactac tggggccagg gcaccaccct gaccgtgagc agcaccacga cgccagcgcc      780

gcgaccacca acaccggcgc ccaccatcgc gtcgcagccc ctgtccctgc gcccagaggc      840

gtgccggcca gcggcggggg gcgcagtgca cacgaggggg ctggacttcg cctgtgatat      900

ctacatctgg gcgcccttgg ccgggacttg tggggtcctt ctcctgtcac tggttatcac      960

cctttactgc aggagtaaga ggagcaggct cctgcacagt gactacatga acatgactcc     1020

ccgccgcccc gggcccaccc gcaagcatta ccagccctat gccccaccac gcgacttcgc     1080

agcctatcgc tccagagtga agttcagcag gagcgcagac gcccccgcgt accagcaggg     1140

ccagaaccag ctctataacg agctcatcta ggacgaagag aggagtacga tgttttggac     1200

aagagacgtg gccgggaccc tgagatgggg ggaaagccgc agagaaggaa gaaccctcag     1260

gaaggcctgt acaatgaact gcagaaagat aagatggcgg aggcctacag tgagattggg     1320

atgaaaggcg agcgccggag gggcaagggg cacgatggcc tttaccaggg tctcagtaca     1380

gccaccaagg acacctacga cgcccttcac atgcaggccc tgccccctcg cggaagcgga     1440

gccaccaact tcagcctgct gaagcaggcc ggcgacgtgg aggagaaccc cggccccatg     1500

gccctgcccg tgaccgccct gctgctgccc ctggccctgc tgctgcacgc cgccaggccc     1560

atggccgact acaaggacat cgtgatgacc cagagccaca agttcctgct ggtgagcgtg     1620

ggcgacaggg tgagcatcac ctgcaaggcc agccaggacg tgagcaccgc cgtggcctgg     1680

taccagcaga agcccggcca gagccccaag ctgctgatct acagcgccag ctacaggtac     1740

accggcgtgc ccgacaggtt catcggcagc ggcagcggca ccgacttcac cctgaccatc     1800

agcagcgtgc aggccgagga cctggccgac tacttctgcc agcagcacta cagcaccccc     1860

ctgaccttcg gcgccggcac caagctggag atcaagaggg gcggcggcgg cagcggcggc     1920

ggcggcagcg gcggcggcgg cagcagcggc ggcggcagcg aggtgcagct gaaggagagc     1980

ggccccggcc tggtggcccc cagccagagc ctgagcatca cctgcaccgt gagcggcttc     2040

cccctgacca gctacggcgt gagctgggtg aggcagcccc ccggcaaggg cctggagtgg     2100

ctgggcgtga tctggggcga cggcagcacc aactaccaca gcgccctgat cagcaggctg     2160

agcatcagca aggacaacag caagagccag gtgttcctga agctgaacaa cctgcagacc     2220

gacgacaccg ccacctacta ctgcgccagg gacacctact acccctacta cgccatggac     2280

tactggggcc agggcaccag cgtgaccgtg agcagcacca ccacccccgc ccccaggccc     2340

cccacccccg cccccaccat cgccagccag cccctgagcc tgaggcccga ggcctgcagg     2400

cccgccgccg gcggcgccgt gcacaccagg ggcctggact tcgcctgcga catctacatc     2460

tgggcccccc tggccggcac ctgcggcgtg ctgctgctga gcctggtgat caccctgtac     2520

tgcaaacggg gcagaaagaa actcctgtat atattcaaac aaccatttat gagaccagta     2580

caaactactc aagaggaaga tggctgtagc tgccgatttc cagaagaaga agaaggagga     2640

tgtgaactga gggtgaagtt cagcaggagc gccgacgccc ccgcctacca gcagggccag     2700

aaccagctgt acaacgagct gaacctgggc aggagggagg agtacgacgt gctggacaag     2760

aggaggggca gggaccccga gatgggcggc aagccccaga ggaggaagaa cccccaggag     2820

ggcctgtaca acgagctgca gaaggacaag atggccgagg cctacagcga gatcggcatg     2880

aagggcgaga ggaggagggg caagggccac gacggcctgt accagggcct gagcaccgcc     2940

accaaggaca cctacgacgc cctgcacatg caggccctgc cccccaggta agtttaaac      2999


<210>  158
<211>  78
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  (extracellular domain of BAFF-receptor amino acid sequence)

<400>  158

Met Arg Arg Gly Pro Arg Ser Leu Arg Gly Arg Asp Ala Pro Ala Pro 
1               5                   10                  15      


Thr Pro Cys Val Pro Ala Glu Cys Phe Asp Leu Leu Val Arg His Cys 
            20                  25                  30          


Val Ala Cys Gly Leu Leu Arg Thr Pro Arg Pro Lys Pro Ala Gly Ala 
        35                  40                  45              


Ser Ser Pro Ala Pro Arg Thr Ala Leu Gln Pro Gln Glu Ser Val Gly 
    50                  55                  60                  


Ala Gly Ala Gly Glu Ala Ala Leu Pro Leu Pro Gly Leu Leu 
65                  70                  75              


<210>  159
<211>  2663
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  (L8-CD7-28-52 -IL-15/IL-15sushi CAR nucleotide sequence)

<400>  159
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccgggcgccc agcccgccat ggccgcctac aaggacatcc agatgaccca gaccaccagc      120

agcctgagcg ccagcctggg cgacagagtg accatcagct gcagcgccag ccagggcatc      180

agcaactacc tgaactggta ccagcagaag cccgacggca ccaacaagct gctgatctac      240

tacaccagca gcctgcacag cggcgtgccc agcagattca gcggcagcgg cagcggcacc      300

gactacagcc tgcacagcaa cctggagccc gaggacatcg ccacctacta ctgccagcag      360

tacagcaagc tgccctacac cttcggcggc ggcaccaagc tggagatcaa gagaggcggc      420

ggcggcagcg gcggcggcgg cagcggcggc ggcggcagcg gcggcggcgg cagcgaggtg      480

cagctggtgg agagcggcgg cggcctggtg aagcccggcg gcagcctgaa gctgagctgc      540

gccgccagcg gcctgacctt cagcagctac gccatgagct ggaacagaca gacccccgag      600

aagagactgg agtgggtggc cagcatcagc agcggcggct tcacctacta ccccgacagc      660

aacaagggca gattcaccat cagcagagac aacgccagaa acatcctgta cctgcagatg      720

agcagcctga gaagcgagga caccgccatg tactactgcg ccagagacga ggtgagaggc      780

tacctggacg tgtggggcgc cggcaccacc gtgaccgtga gcagcaccac gacgccagcg      840

ccgcgaccac caacaccggc gcccaccatc gcgtcgcagc ccctgtccct gcgcccagag      900

gcgtgccggc cagcggcggg gggcgcagtg cacacgaggg ggctggactt cgcctgtgat      960

atctacatct gggcgccctt ggccgggact tgtggggtcc ttctcctgtc actggttatc     1020

accctttact gcaggagtaa gaggagcagg ctcctgcaca gtgactacat gaacatgact     1080

ccccgccgcc ccgggcccac ccgcaagcat taccagccct atgccccacc acgcgacttc     1140

gcagcctatc gctccagagt gaagttcagc aggagcgcag acgcccccgc gtaccagcag     1200

ggccagaacc agctctataa cgagctcaat ctaggacgaa gagaggagta cgatgttttg     1260

gacaagagac gtggccggga ccctgagatg gggggaaagc cgcagagaag gaagaaccct     1320

caggaaggcc tgtacaatga actgcagaaa gataagatgg cggaggccta cagtgagatt     1380

gggatgaaag gcgagcgccg gaggggcaag gggcacgatg gcctttacca gggtctcagt     1440

acagccacca aggacaccta cgacgccctt cacatgcagg ccctgccccc tcgcggcagc     1500

ggcgaaggcc gcggcagcct gctgacctgc ggcgatgtgg aagaaaaccc gggccccatg     1560

gccctgcccg tgaccgccct gctgctgccc ctggccctgc tgctgcacgc cgccaggccc     1620

ggccagaacg acaccagcca gaccagcagc cccagcagcc cgctgtttcc gggcccgagc     1680

aaaccgtttt gggtgctggt ggtggtgggc ggcgtgctgg cgtgctatag cctgctggtg     1740

accgtggcgt ttattatttt ttgggtggga agcggagcta ctaacttgag cctgctgaag     1800

caggctggag acgtggagga gaaccctgga cctatgtaca gaatgcagct gctgagctgc     1860

atcgccctga gcctggccct ggtgaccaac agcggcatcc acgtgttcat cctgggctgc     1920

ttcagcgccg gcctgcccaa gaccgaggcc aactgggtga acgtgatcag cgacctgaag     1980

aagatcgagg acctgatcca gagcatgcac atcgacgcca ccctgtacac cgagagcgac     2040

gtgcacccca gctgcaaggt gaccgccatg aagtgcttcc tgctggagct gcaggtgatc     2100

agcctggaga gcggcgacgc cagcatccac gacaccgtgg agaacctgat catcctggcc     2160

aacaacagcc tgagcagcaa cggcaacgtg accgagagcg gctgcaagga gtgcgaggag     2220

ctggaggaga agaacatcaa ggagttcctg cagagcttcg tgcacatcgt gcagatgttc     2280

atcaacacca gctccggcgg cggctccggc ggcggcggct ccggcggcgg cggctccggc     2340

ggcggcggct ccggcggcgg ctccctgcag gcccccagaa gagccagagg ctgcagaacc     2400

ctgggcctgc ccgccctgct gctgctgctg ctgctgagac cccccgccac cagaggcatc     2460

acctgccccc cccccatgag cgtggagcac gccgacatct gggtgaagag ctacagcctg     2520

tacagcagag agagatacat ctgcaacagc ggcttcaaga gaaaggccgg caccagcagc     2580

ctgaccgagt gcgtgctgaa caaggccacc aacgtggccc actggaccac ccccagcctg     2640

aagtgcatca gataagttta aac                                             2663


<210>  160
<211>  884
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  (L8-CD7-28-52 -IL-15/IL-15sushi CAR amino acid sequence)

<400>  160

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gly Ala Gln Pro Ala Met Ala Ala Tyr Lys Asp 
            20                  25                  30          


Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly Asp 
        35                  40                  45              


Arg Val Thr Ile Ser Cys Ser Ala Ser Gln Gly Ile Ser Asn Tyr Leu 
    50                  55                  60                  


Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Asn Lys Leu Leu Ile Tyr 
65                  70                  75                  80  


Tyr Thr Ser Ser Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
                85                  90                  95      


Gly Ser Gly Thr Asp Tyr Ser Leu His Ser Asn Leu Glu Pro Glu Asp 
            100                 105                 110         


Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr Ser Lys Leu Pro Tyr Thr Phe 
        115                 120                 125             


Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Gly Gly Gly Gly Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val 
145                 150                 155                 160 


Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly Ser Leu 
                165                 170                 175     


Lys Leu Ser Cys Ala Ala Ser Gly Leu Thr Phe Ser Ser Tyr Ala Met 
            180                 185                 190         


Ser Trp Asn Arg Gln Thr Pro Glu Lys Arg Leu Glu Trp Val Ala Ser 
        195                 200                 205             


Ile Ser Ser Gly Gly Phe Thr Tyr Tyr Pro Asp Ser Asn Lys Gly Arg 
    210                 215                 220                 


Phe Thr Ile Ser Arg Asp Asn Ala Arg Asn Ile Leu Tyr Leu Gln Met 
225                 230                 235                 240 


Ser Ser Leu Arg Ser Glu Asp Thr Ala Met Tyr Tyr Cys Ala Arg Asp 
                245                 250                 255     


Glu Val Arg Gly Tyr Leu Asp Val Trp Gly Ala Gly Thr Thr Val Thr 
            260                 265                 270         


Val Ser Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro 
        275                 280                 285             


Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro 
    290                 295                 300                 


Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp 
305                 310                 315                 320 


Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu 
                325                 330                 335     


Ser Leu Val Ile Thr Leu Tyr Cys Arg Ser Lys Arg Ser Arg Leu Leu 
            340                 345                 350         


His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg 
        355                 360                 365             


Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg 
    370                 375                 380                 


Ser Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln 
385                 390                 395                 400 


Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu 
                405                 410                 415     


Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly 
            420                 425                 430         


Lys Pro Gln Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu 
        435                 440                 445             


Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly 
    450                 455                 460                 


Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser 
465                 470                 475                 480 


Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro 
                485                 490                 495     


Pro Arg Gly Ser Gly Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp 
            500                 505                 510         


Val Glu Glu Asn Pro Gly Pro Met Ala Leu Pro Val Thr Ala Leu Leu 
        515                 520                 525             


Leu Pro Leu Ala Leu Leu Leu His Ala Ala Arg Pro Gly Gln Asn Asp 
    530                 535                 540                 


Thr Ser Gln Thr Ser Ser Pro Ser Ser Pro Leu Phe Pro Gly Pro Ser 
545                 550                 555                 560 


Lys Pro Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr 
                565                 570                 575     


Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Gly Ser Gly 
            580                 585                 590         


Ala Thr Asn Leu Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn 
        595                 600                 605             


Pro Gly Pro Met Tyr Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser 
    610                 615                 620                 


Leu Ala Leu Val Thr Asn Ser Gly Ile His Val Phe Ile Leu Gly Cys 
625                 630                 635                 640 


Phe Ser Ala Gly Leu Pro Lys Thr Glu Ala Asn Trp Val Asn Val Ile 
                645                 650                 655     


Ser Asp Leu Lys Lys Ile Glu Asp Leu Ile Gln Ser Met His Ile Asp 
            660                 665                 670         


Ala Thr Leu Tyr Thr Glu Ser Asp Val His Pro Ser Cys Lys Val Thr 
        675                 680                 685             


Ala Met Lys Cys Phe Leu Leu Glu Leu Gln Val Ile Ser Leu Glu Ser 
    690                 695                 700                 


Gly Asp Ala Ser Ile His Asp Thr Val Glu Asn Leu Ile Ile Leu Ala 
705                 710                 715                 720 


Asn Asn Ser Leu Ser Ser Asn Gly Asn Val Thr Glu Ser Gly Cys Lys 
                725                 730                 735     


Glu Cys Glu Glu Leu Glu Glu Lys Asn Ile Lys Glu Phe Leu Gln Ser 
            740                 745                 750         


Phe Val His Ile Val Gln Met Phe Ile Asn Thr Ser Ser Gly Gly Gly 
        755                 760                 765             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    770                 775                 780                 


Gly Gly Gly Ser Leu Gln Ala Pro Arg Arg Ala Arg Gly Cys Arg Thr 
785                 790                 795                 800 


Leu Gly Leu Pro Ala Leu Leu Leu Leu Leu Leu Leu Arg Pro Pro Ala 
                805                 810                 815     


Thr Arg Gly Ile Thr Cys Pro Pro Pro Met Ser Val Glu His Ala Asp 
            820                 825                 830         


Ile Trp Val Lys Ser Tyr Ser Leu Tyr Ser Arg Glu Arg Tyr Ile Cys 
        835                 840                 845             


Asn Ser Gly Phe Lys Arg Lys Ala Gly Thr Ser Ser Leu Thr Glu Cys 
    850                 855                 860                 


Val Leu Asn Lys Ala Thr Asn Val Ala His Trp Thr Thr Pro Ser Leu 
865                 870                 875                 880 


Lys Cys Ile Arg 
                


<210>  161
<211>  201
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  (CLL-1 antigen recognition domain amino acid sequence)

<400>  161

His Val Thr Leu Lys Ile Glu Met Lys Lys Met Asn Lys Leu Gln Asn 
1               5                   10                  15      


Ile Ser Glu Glu Leu Gln Arg Asn Ile Ser Leu Gln Leu Met Ser Asn 
            20                  25                  30          


Met Asn Ile Ser Asn Lys Ile Arg Asn Leu Ser Thr Thr Leu Gln Thr 
        35                  40                  45              


Ile Ala Thr Lys Leu Cys Arg Glu Leu Tyr Ser Lys Glu Gln Glu His 
    50                  55                  60                  


Lys Cys Lys Pro Cys Pro Arg Arg Trp Ile Trp His Lys Asp Ser Cys 
65                  70                  75                  80  


Tyr Phe Leu Ser Asp Asp Val Gln Thr Trp Gln Glu Ser Lys Met Ala 
                85                  90                  95      


Cys Ala Ala Gln Asn Ala Ser Leu Leu Lys Ile Asn Asn Lys Asn Ala 
            100                 105                 110         


Leu Glu Phe Ile Lys Ser Gln Ser Arg Ser Tyr Asp Tyr Trp Leu Gly 
        115                 120                 125             


Leu Ser Pro Glu Glu Asp Ser Thr Arg Gly Met Arg Val Asp Asn Ile 
    130                 135                 140                 


Ile Asn Ser Ser Ala Trp Val Ile Arg Asn Ala Pro Asp Leu Asn Asn 
145                 150                 155                 160 


Met Tyr Cys Gly Tyr Ile Asn Arg Leu Tyr Val Gln Tyr Tyr His Cys 
                165                 170                 175     


Thr Tyr Lys Lys Arg Met Ile Cys Glu Lys Met Ala Asn Pro Val Gln 
            180                 185                 190         


Leu Gly Ser Thr Tyr Phe Arg Glu Ala 
        195                 200     


<210>  162
<211>  793
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  (L8-CD7-28-IL-15/IL-15sushi CAR amino acid sequence)

<400>  162

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gly Ala Gln Pro Ala Met Ala Ala Tyr Lys Asp 
            20                  25                  30          


Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly Asp 
        35                  40                  45              


Arg Val Thr Ile Ser Cys Ser Ala Ser Gln Gly Ile Ser Asn Tyr Leu 
    50                  55                  60                  


Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Asn Lys Leu Leu Ile Tyr 
65                  70                  75                  80  


Tyr Thr Ser Ser Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
                85                  90                  95      


Gly Ser Gly Thr Asp Tyr Ser Leu His Ser Asn Leu Glu Pro Glu Asp 
            100                 105                 110         


Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr Ser Lys Leu Pro Tyr Thr Phe 
        115                 120                 125             


Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Gly Gly Gly Gly Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val 
145                 150                 155                 160 


Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly Ser Leu 
                165                 170                 175     


Lys Leu Ser Cys Ala Ala Ser Gly Leu Thr Phe Ser Ser Tyr Ala Met 
            180                 185                 190         


Ser Trp Asn Arg Gln Thr Pro Glu Lys Arg Leu Glu Trp Val Ala Ser 
        195                 200                 205             


Ile Ser Ser Gly Gly Phe Thr Tyr Tyr Pro Asp Ser Asn Lys Gly Arg 
    210                 215                 220                 


Phe Thr Ile Ser Arg Asp Asn Ala Arg Asn Ile Leu Tyr Leu Gln Met 
225                 230                 235                 240 


Ser Ser Leu Arg Ser Glu Asp Thr Ala Met Tyr Tyr Cys Ala Arg Asp 
                245                 250                 255     


Glu Val Arg Gly Tyr Leu Asp Val Trp Gly Ala Gly Thr Thr Val Thr 
            260                 265                 270         


Val Ser Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro 
        275                 280                 285             


Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro 
    290                 295                 300                 


Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp 
305                 310                 315                 320 


Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu 
                325                 330                 335     


Ser Leu Val Ile Thr Leu Tyr Cys Arg Ser Lys Arg Ser Arg Leu Leu 
            340                 345                 350         


His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg 
        355                 360                 365             


Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg 
    370                 375                 380                 


Ser Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln 
385                 390                 395                 400 


Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu 
                405                 410                 415     


Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly 
            420                 425                 430         


Lys Pro Gln Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu 
        435                 440                 445             


Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly 
    450                 455                 460                 


Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser 
465                 470                 475                 480 


Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro 
                485                 490                 495     


Pro Arg Gly Ser Gly Ala Thr Asn Leu Ser Leu Leu Lys Gln Ala Gly 
            500                 505                 510         


Asp Val Glu Glu Asn Pro Gly Pro Met Tyr Arg Met Gln Leu Leu Ser 
        515                 520                 525             


Cys Ile Ala Leu Ser Leu Ala Leu Val Thr Asn Ser Gly Ile His Val 
    530                 535                 540                 


Phe Ile Leu Gly Cys Phe Ser Ala Gly Leu Pro Lys Thr Glu Ala Asn 
545                 550                 555                 560 


Trp Val Asn Val Ile Ser Asp Leu Lys Lys Ile Glu Asp Leu Ile Gln 
                565                 570                 575     


Ser Met His Ile Asp Ala Thr Leu Tyr Thr Glu Ser Asp Val His Pro 
            580                 585                 590         


Ser Cys Lys Val Thr Ala Met Lys Cys Phe Leu Leu Glu Leu Gln Val 
        595                 600                 605             


Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile His Asp Thr Val Glu Asn 
    610                 615                 620                 


Leu Ile Ile Leu Ala Asn Asn Ser Leu Ser Ser Asn Gly Asn Val Thr 
625                 630                 635                 640 


Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu Lys Asn Ile Lys 
                645                 650                 655     


Glu Phe Leu Gln Ser Phe Val His Ile Val Gln Met Phe Ile Asn Thr 
            660                 665                 670         


Ser Ser Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        675                 680                 685             


Gly Gly Gly Gly Ser Gly Gly Gly Ser Leu Gln Ala Pro Arg Arg Ala 
    690                 695                 700                 


Arg Gly Cys Arg Thr Leu Gly Leu Pro Ala Leu Leu Leu Leu Leu Leu 
705                 710                 715                 720 


Leu Arg Pro Pro Ala Thr Arg Gly Ile Thr Cys Pro Pro Pro Met Ser 
                725                 730                 735     


Val Glu His Ala Asp Ile Trp Val Lys Ser Tyr Ser Leu Tyr Ser Arg 
            740                 745                 750         


Glu Arg Tyr Ile Cys Asn Ser Gly Phe Lys Arg Lys Ala Gly Thr Ser 
        755                 760                 765             


Ser Leu Thr Glu Cys Val Leu Asn Lys Ala Thr Asn Val Ala His Trp 
    770                 775                 780                 


Thr Thr Pro Ser Leu Lys Cys Ile Arg 
785                 790             


<210>  163
<211>  2398
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  (L8-CD7-28-IL-15/IL-15sushi CAR nucleotide sequence)

<400>  163
gcgatcgcat ggccttacca gtgaccgcct tgctcctgcc gctggccttg ctgctccacg       60

ccgccaggcc gggcgcccag cccgccatgg ccgcctacaa ggacatccag atgacccaga      120

ccaccagcag cctgagcgcc agcctgggcg acagagtgac catcagctgc agcgccagcc      180

agggcatcag caactacctg aactggtacc agcagaagcc cgacggcacc aacaagctgc      240

tgatctacta caccagcagc ctgcacagcg gcgtgcccag cagattcagc ggcagcggca      300

gcggcaccga ctacagcctg cacagcaacc tggagcccga ggacatcgcc acctactact      360

gccagcagta cagcaagctg ccctacacct tcggcggcgg caccaagctg gagatcaaga      420

gaggcggcgg cggcagcggc ggcggcggca gcggcggcgg cggcagcggc ggcggcggca      480

gcgaggtgca gctggtggag agcggcggcg gcctggtgaa gcccggcggc agcctgaagc      540

tgagctgcgc cgccagcggc ctgaccttca gcagctacgc catgagctgg aacagacaga      600

cccccgagaa gagactggag tgggtggcca gcatcagcag cggcggcttc acctactacc      660

ccgacagcaa caagggcaga ttcaccatca gcagagacaa cgccagaaac atcctgtacc      720

tgcagatgag cagcctgaga agcgaggaca ccgccatgta ctactgcgcc agagacgagg      780

tgagaggcta cctggacgtg tggggcgccg gcaccaccgt gaccgtgagc agcaccacga      840

cgccagcgcc gcgaccacca acaccggcgc ccaccatcgc gtcgcagccc ctgtccctgc      900

gcccagaggc gtgccggcca gcggcggggg gcgcagtgca cacgaggggg ctggacttcg      960

cctgtgatat ctacatctgg gcgcccttgg ccgggacttg tggggtcctt ctcctgtcac     1020

tggttatcac cctttactgc aggagtaaga ggagcaggct cctgcacagt gactacatga     1080

acatgactcc ccgccgcccc gggcccaccc gcaagcatta ccagccctat gccccaccac     1140

gcgacttcgc agcctatcgc tccagagtga agttcagcag gagcgcagac gcccccgcgt     1200

accagcaggg ccagaaccag ctctataacg agctcaatct aggacgaaga gaggagtacg     1260

atgttttgga caagagacgt ggccgggacc ctgagatggg gggaaagccg cagagaagga     1320

agaaccctca ggaaggcctg tacaatgaac tgcagaaaga taagatggcg gaggcctaca     1380

gtgagattgg gatgaaaggc gagcgccgga ggggcaaggg gcacgatggc ctttaccagg     1440

gtctcagtac agccaccaag gacacctacg acgcccttca catgcaggcc ctgccccctc     1500

gcggaagcgg agctactaac ttgagcctgc tgaagcaggc tggagacgtg gaggagaacc     1560

ctggacctat gtacagaatg cagctgctga gctgcatcgc cctgagcctg gccctggtga     1620

ccaacagcgg catccacgtg ttcatcctgg gctgcttcag cgccggcctg cccaagaccg     1680

aggccaactg ggtgaacgtg atcagcgacc tgaagaagat cgaggacctg atccagagca     1740

tgcacatcga cgccaccctg tacaccgaga gcgacgtgca ccccagctgc aaggtgaccg     1800

ccatgaagtg cttcctgctg gagctgcagg tgatcagcct ggagagcggc gacgccagca     1860

tccacgacac cgtggagaac ctgatcatcc tggccaacaa cagcctgagc agcaacggca     1920

acgtgaccga gagcggctgc aaggagtgcg aggagctgga ggagaagaac atcaaggagt     1980

tcctgcagag cttcgtgcac atcgtgcaga tgttcatcaa caccagctcc ggcggcggct     2040

ccggcggcgg cggctccggc ggcggcggct ccggcggcgg cggctccggc ggcggctccc     2100

tgcaggcccc cagaagagcc agaggctgca gaaccctggg cctgcccgcc ctgctgctgc     2160

tgctgctgct gagacccccc gccaccagag gcatcacctg cccccccccc atgagcgtgg     2220

agcacgccga catctgggtg aagagctaca gcctgtacag cagagagaga tacatctgca     2280

acagcggctt caagagaaag gccggcacca gcagcctgac cgagtgcgtg ctgaacaagg     2340

ccaccaacgt ggcccactgg accaccccca gcctgaagtg catcagataa gtttaaac       2398


<210>  164
<211>  767
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  (CD19b-28-4-1BBL CAR amino acid sequence)

<400>  164

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu 
            20                  25                  30          


Ile Lys Pro Gly Ala Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr 
        35                  40                  45              


Thr Phe Thr Ser Tyr Val Met His Trp Val Lys Gln Lys Pro Gly Gln 
    50                  55                  60                  


Gly Leu Glu Trp Ile Gly Tyr Ile Asn Pro Tyr Asn Asp Gly Thr Lys 
65                  70                  75                  80  


Tyr Asn Glu Lys Phe Lys Gly Lys Ala Thr Leu Thr Ser Asp Lys Ser 
                85                  90                  95      


Ser Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Thr Ser Glu Asp Ser 
            100                 105                 110         


Ala Val Tyr Tyr Cys Ala Arg Gly Thr Tyr Tyr Tyr Gly Ser Arg Val 
        115                 120                 125             


Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val 
145                 150                 155                 160 


Met Thr Gln Ala Ala Pro Ser Ile Pro Val Thr Pro Gly Glu Ser Val 
                165                 170                 175     


Ser Ile Ser Cys Arg Ser Ser Lys Ser Leu Leu Asn Ser Asn Gly Asn 
            180                 185                 190         


Thr Tyr Leu Tyr Trp Phe Leu Gln Arg Pro Gly Gln Ser Pro Gln Leu 
        195                 200                 205             


Leu Ile Tyr Arg Met Ser Asn Leu Ala Ser Gly Val Pro Asp Arg Phe 
    210                 215                 220                 


Ser Gly Ser Gly Ser Gly Thr Ala Phe Thr Leu Arg Ile Ser Arg Val 
225                 230                 235                 240 


Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln His Leu Glu Tyr 
                245                 250                 255     


Pro Phe Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Arg Thr Thr 
            260                 265                 270         


Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln 
        275                 280                 285             


Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala 
    290                 295                 300                 


Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala 
305                 310                 315                 320 


Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr 
                325                 330                 335     


Leu Tyr Cys Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met 
            340                 345                 350         


Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro 
        355                 360                 365             


Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Arg Val Lys Phe 
    370                 375                 380                 


Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu 
385                 390                 395                 400 


Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp 
                405                 410                 415     


Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys 
            420                 425                 430         


Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala 
        435                 440                 445             


Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys 
    450                 455                 460                 


Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr 
465                 470                 475                 480 


Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg Gly Ser Gly Glu 
                485                 490                 495     


Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp Val Glu Glu Asn Pro Gly 
            500                 505                 510         


Pro Met Glu Tyr Ala Ser Asp Ala Ser Leu Asp Pro Glu Ala Pro Trp 
        515                 520                 525             


Pro Pro Ala Pro Arg Ala Arg Ala Cys Arg Val Leu Pro Trp Ala Leu 
    530                 535                 540                 


Val Ala Gly Leu Leu Leu Leu Leu Leu Leu Ala Ala Ala Cys Ala Val 
545                 550                 555                 560 


Phe Leu Ala Cys Pro Trp Ala Val Ser Gly Ala Arg Ala Ser Pro Gly 
                565                 570                 575     


Ser Ala Ala Ser Pro Arg Leu Arg Glu Gly Pro Glu Leu Ser Pro Asp 
            580                 585                 590         


Asp Pro Ala Gly Leu Leu Asp Leu Arg Gln Gly Met Phe Ala Gln Leu 
        595                 600                 605             


Val Ala Gln Asn Val Leu Leu Ile Asp Gly Pro Leu Ser Trp Tyr Ser 
    610                 615                 620                 


Asp Pro Gly Leu Ala Gly Val Ser Leu Thr Gly Gly Leu Ser Tyr Lys 
625                 630                 635                 640 


Glu Asp Thr Lys Glu Leu Val Val Ala Lys Ala Gly Val Tyr Tyr Val 
                645                 650                 655     


Phe Phe Gln Leu Glu Leu Arg Arg Val Val Ala Gly Glu Gly Ser Gly 
            660                 665                 670         


Ser Val Ser Leu Ala Leu His Leu Gln Pro Leu Arg Ser Ala Ala Gly 
        675                 680                 685             


Ala Ala Ala Leu Ala Leu Thr Val Asp Leu Pro Pro Ala Ser Ser Glu 
    690                 695                 700                 


Ala Arg Asn Ser Ala Phe Gly Phe Gln Gly Arg Leu Leu His Leu Ser 
705                 710                 715                 720 


Ala Gly Gln Arg Leu Gly Val His Leu His Thr Glu Ala Arg Ala Arg 
                725                 730                 735     


His Ala Trp Gln Leu Thr Gln Gly Ala Thr Val Leu Gly Leu Phe Arg 
            740                 745                 750         


Val Thr Pro Glu Ile Pro Ala Gly Leu Pro Ser Pro Arg Ser Glu 
        755                 760                 765         


<210>  165
<211>  2320
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  (CD19b-28-4-1BBL CAR nucleotide sequence)

<400>  165
gcgatcgcat ggccttacca gtgaccgcct tgctcctgcc gctggccttg ctgctccacg       60

ccgccaggcc ggaggtccag ctgcagcagt ctggacctga gctgataaag cctggggctt      120

cagtgaagat gtcctgcaag gcttctggat acacattcac tagctatgtt atgcactggg      180

tgaagcagaa gcctgggcag ggccttgagt ggattggata tattaatcct tacaatgatg      240

gtactaagta caatgagaag ttcaaaggca aggccacact gacttcagac aaatcctcca      300

gcacagccta catggagctc agcagcctga cctctgagga ctctgcggtc tattactgtg      360

caagagggac ttattactac ggtagtaggg tatttgacta ctggggccaa ggcaccactc      420

tcacagtctc ctcaggtgga gggggctcag gcggaggtgg ctctgggggt ggaggctcgg      480

acattgtgat gactcaggct gcaccctcta tacctgtcac tcctggagag tcagtatcca      540

tctcctgcag gtctagtaag agtctcctga atagtaatgg caacacttac ttgtattggt      600

tcctgcagag gccaggccag tctcctcagc tcctgatata tcggatgtcc aaccttgcct      660

caggagtccc agacaggttc agtggcagtg ggtcaggaac tgctttcaca ctgagaatca      720

gtagagtgga ggctgaggat gtgggtgttt attactgtat gcaacatcta gaatatccgt      780

tcacgttcgg tgctgggacc aagctggagc tgaaacggac cacgacgcca gcgccgcgac      840

caccaacacc ggcgcccacc atcgcgtcgc agcccctgtc cctgcgccca gaggcgtgcc      900

ggccagcggc ggggggcgca gtgcacacga gggggctgga cttcgcctgt gatatctaca      960

tctgggcgcc cttggccggg acttgtgggg tccttctcct gtcactggtt atcacccttt     1020

actgcaggag taagaggagc aggctcctgc acagtgacta catgaacatg actccccgcc     1080

gccccgggcc cacccgcaag cattaccagc cctatgcccc accacgcgac ttcgcagcct     1140

atcgctccag agtgaagttc agcaggagcg cagacgcccc cgcgtaccag cagggccaga     1200

accagctcta taacgagctc aatctaggac gaagagagga gtacgatgtt ttggacaaga     1260

gacgtggccg ggaccctgag atggggggaa agccgagaag gaagaaccct caggaaggcc     1320

tgtacaatga actgcagaaa gataagatgg cggaggccta cagtgagatt gggatgaaag     1380

gcgagcgccg gaggggcaag gggcacgatg gcctttacca gggtctcagt acagccacca     1440

aggacaccta cgacgccctt cacatgcagg ccctgccccc tcgcggcagc ggcgaaggcc     1500

gcggcagcct gctgacctgc ggcgatgtgg aagaaaaccc gggccccatg gaatacgcct     1560

ctgacgcttc actggacccc gaagccccgt ggcctcccgc gccccgcgct cgcgcctgcc     1620

gcgtactgcc ttgggccctg gtcgcggggc tgctgctgct gctgctgctc gctgccgcct     1680

gcgccgtctt cctcgcctgc ccctgggccg tgtccggggc tcgcgcctcg cccggctccg     1740

cggccagccc gagactccgc gagggtcccg agctttcgcc cgacgatccc gccggcctct     1800

tggacctgcg gcagggcatg tttgcgcagc tggtggccca aaatgttctg ctgatcgatg     1860

ggcccctgag ctggtacagt gacccaggcc tggcaggcgt gtccctgacg gggggcctga     1920

gctacaaaga ggacacgaag gagctggtgg tggccaaggc tggagtctac tatgtcttct     1980

ttcaactaga gctgcggcgc gtggtggccg gcgagggctc aggctccgtt tcacttgcgc     2040

tgcacctgca gccactgcgc tctgctgctg gggccgccgc cctggctttg accgtggacc     2100

tgccacccgc ctcctccgag gctcggaact cggccttcgg tttccagggc cgcttgctgc     2160

acctgagtgc cggccagcgc ctgggcgtcc atcttcacac tgaggccagg gcacgccatg     2220

cctggcagct tacccagggc gccacagtct tgggactctt ccgggtgacc cccgaaatcc     2280

cagccggact cccttcaccg aggtcggaat aagtttaaac                           2320


<210>  166
<211>  1001
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  (CD19b-CD22b-28 amino acid sequence)

<400>  166

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu 
            20                  25                  30          


Ile Lys Pro Gly Ala Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr 
        35                  40                  45              


Thr Phe Thr Ser Tyr Val Met His Trp Val Lys Gln Lys Pro Gly Gln 
    50                  55                  60                  


Gly Leu Glu Trp Ile Gly Tyr Ile Asn Pro Tyr Asn Asp Gly Thr Lys 
65                  70                  75                  80  


Tyr Asn Glu Lys Phe Lys Gly Lys Ala Thr Leu Thr Ser Asp Lys Ser 
                85                  90                  95      


Ser Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Thr Ser Glu Asp Ser 
            100                 105                 110         


Ala Val Tyr Tyr Cys Ala Arg Gly Thr Tyr Tyr Tyr Gly Ser Arg Val 
        115                 120                 125             


Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val 
145                 150                 155                 160 


Met Thr Gln Ala Ala Pro Ser Ile Pro Val Thr Pro Gly Glu Ser Val 
                165                 170                 175     


Ser Ile Ser Cys Arg Ser Ser Lys Ser Leu Leu Asn Ser Asn Gly Asn 
            180                 185                 190         


Thr Tyr Leu Tyr Trp Phe Leu Gln Arg Pro Gly Gln Ser Pro Gln Leu 
        195                 200                 205             


Leu Ile Tyr Arg Met Ser Asn Leu Ala Ser Gly Val Pro Asp Arg Phe 
    210                 215                 220                 


Ser Gly Ser Gly Ser Gly Thr Ala Phe Thr Leu Arg Ile Ser Arg Val 
225                 230                 235                 240 


Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln His Leu Glu Tyr 
                245                 250                 255     


Pro Phe Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Arg Thr Thr 
            260                 265                 270         


Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln 
        275                 280                 285             


Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala 
    290                 295                 300                 


Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala 
305                 310                 315                 320 


Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr 
                325                 330                 335     


Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln 
            340                 345                 350         


Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser 
        355                 360                 365             


Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys 
    370                 375                 380                 


Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln 
385                 390                 395                 400 


Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu 
                405                 410                 415     


Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Gln Arg 
            420                 425                 430         


Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys 
        435                 440                 445             


Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg 
    450                 455                 460                 


Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys 
465                 470                 475                 480 


Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg Gly Ser 
                485                 490                 495     


Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu 
            500                 505                 510         


Asn Pro Gly Pro Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu 
        515                 520                 525             


Ala Leu Leu Leu His Ala Ala Arg Pro Gln Val Gln Leu Gln Glu Ser 
    530                 535                 540                 


Gly Ala Glu Leu Ser Lys Pro Gly Ala Ser Val Lys Met Ser Cys Lys 
545                 550                 555                 560 


Ala Ser Gly Tyr Thr Phe Thr Ser Tyr Trp Leu His Trp Ile Lys Gln 
                565                 570                 575     


Arg Pro Gly Gln Gly Leu Glu Trp Ile Gly Tyr Ile Asn Pro Arg Asn 
            580                 585                 590         


Asp Tyr Thr Glu Tyr Asn Gln Asn Phe Lys Asp Lys Ala Thr Leu Thr 
        595                 600                 605             


Ala Asp Lys Ser Ser Ser Thr Ala Tyr Met Gln Leu Ser Ser Leu Thr 
    610                 615                 620                 


Ser Glu Asp Ser Ala Val Tyr Tyr Cys Ala Arg Arg Asp Ile Thr Thr 
625                 630                 635                 640 


Phe Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser Gly Gly Gly 
                645                 650                 655     


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Leu 
            660                 665                 670         


Thr Gln Ser Pro Ser Ser Leu Ala Val Ser Ala Gly Glu Asn Val Thr 
        675                 680                 685             


Met Ser Cys Lys Ser Ser Gln Ser Val Leu Tyr Ser Ala Asn His Lys 
    690                 695                 700                 


Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu 
705                 710                 715                 720 


Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val Pro Asp Arg Phe 
                725                 730                 735     


Thr Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Val Gln Val 
            740                 745                 750         


Glu Asp Leu Ala Ile Tyr Tyr Cys His Gln Tyr Leu Ser Ser Trp Thr 
        755                 760                 765             


Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Thr Thr Thr Pro Ala 
    770                 775                 780                 


Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser 
785                 790                 795                 800 


Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr 
                805                 810                 815     


Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala 
            820                 825                 830         


Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys 
        835                 840                 845             


Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr 
    850                 855                 860                 


Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro 
865                 870                 875                 880 


Pro Arg Asp Phe Ala Ala Tyr Arg Ser Arg Val Lys Phe Ser Arg Ser 
                885                 890                 895     


Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu 
            900                 905                 910         


Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg 
        915                 920                 925             


Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln 
    930                 935                 940                 


Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr 
945                 950                 955                 960 


Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp 
                965                 970                 975     


Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala 
            980                 985                 990         


Leu His Met Gln Ala Leu Pro Pro  Arg 
        995                 1000     


<210>  167
<211>  3014
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  (CD19b-CD22b-28 CAR nucleotide sequence)

<400>  167
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccggaggtcc agctgcagca gtctggacct gagctgataa agcctggggc ttcagtgaag      120

atgtcctgca aggcttctgg atacacattc actagctatg ttatgcactg ggtgaagcag      180

aagcctgggc agggccttga gtggattgga tatattaatc cttacaatga tggtactaag      240

tacaatgaga agttcaaagg caaggccaca ctgacttcag acaaatcctc cagcacagcc      300

tacatggagc tcagcagcct gacctctgag gactctgcgg tctattactg tgcaagaggg      360

acttattact acggtagtag ggtatttgac tactggggcc aaggcaccac tctcacagtc      420

tcctcaggtg gagggggctc aggcggaggt ggctctgggg gtggaggctc ggacattgtg      480

atgactcagg ctgcaccctc tatacctgtc actcctggag agtcagtatc catctcctgc      540

aggtctagta agagtctcct gaatagtaat ggcaacactt acttgtattg gttcctgcag      600

aggccaggcc agtctcctca gctcctgata tatcggatgt ccaaccttgc ctcaggagtc      660

ccagacaggt tcagtggcag tgggtcagga actgctttca cactgagaat cagtagagtg      720

gaggctgagg atgtgggtgt ttattactgt atgcaacatc tagaatatcc gttcacgttc      780

ggtgctggga ccaagctgga gctgaaacgg accacgacgc cagcgccgcg accaccaaca      840

ccggcgccca ccatcgcgtc gcagcccctg tccctgcgcc cagaggcgtg ccggccagcg      900

gcggggggcg cagtgcacac gagggggctg gacttcgcct gtgatatcta catctgggcg      960

cccttggccg ggacttgtgg ggtccttctc ctgtcactgg ttatcaccct ttactgcaaa     1020

cggggcagaa agaaactcct gtatatattc aaacaaccat ttatgagacc agtacaaact     1080

actcaagagg aagatggctg tagctgccga tttccagaag aagaagaagg aggatgtgaa     1140

ctgagagtga agttcagcag gagcgcagac gcccccgcgt accagcaggg ccagaaccag     1200

ctctataacg agctcaatct aggacgaaga gaggagtacg atgttttgga caagagacgt     1260

ggccgggacc ctgagatggg gggaaagccg cagagaagga agaaccctca ggaaggcctg     1320

tacaatgaac tgcagaaaga taagatggcg gaggcctaca gtgagattgg gatgaaaggc     1380

gagcgccgga ggggcaaggg gcacgatggc ctttaccagg gtctcagtac agccaccaag     1440

gacacctacg acgcccttca catgcaggcc ctgccccctc gcggaagcgg agccaccaac     1500

ttcagcctgc tgaagcaggc cggcgacgtg gaggagaacc ccggccccat ggccctgccc     1560

gtgaccgccc tgctgctgcc cctggccctg ctgctgcacg ccgccaggcc ccaggtgcag     1620

ctgcaggaga gcggcgccga gctgagcaag cccggcgcca gcgtgaagat gagctgcaag     1680

gccagcggct acaccttcac cagctactgg ctgcactgga tcaagcagag gcccggccag     1740

ggcctggagt ggatcggcta catcaacccc aggaacgact acaccgagta caaccagaac     1800

ttcaaggaca aggccaccct gaccgccgac aagagcagca gcaccgccta catgcagctg     1860

agcagcctga ccagcgagga cagcgccgtg tactactgcg ccaggaggga catcaccacc     1920

ttctactggg gccagggcac caccctgacc gtgagcagcg gagggggggg atccggggga     1980

ggaggctccg gcggaggcgg aagcgacatc cagctgaccc agagccccag cagcctggcc     2040

gtgagcgccg gcgagaacgt gaccatgagc tgcaagagca gccagagcgt gctgtacagc     2100

gccaaccaca agaactacct ggcctggtac cagcagaagc ccggccagag ccccaagctg     2160

ctgatctact gggccagcac cagggagagc ggcgtgcccg acaggttcac cggcagcggc     2220

accgacttca ccctgaccat cagcagggtg caggtggagg acctggccat ctactactgc     2280

caccagtacc tgagcagctg gaccttcggc ggcggcacca agctggagat caagaggacc     2340

accacccccg cccccaggcc ccccaccccc gcccccacca tcgccagcca gcccctgagc     2400

ctgaggcccg aggcctgcag gcccgccgcc ggcggcgccg tgcacaccag gggcctggac     2460

ttcgcctgcg acatctacat ctgggccccc ctggccggca cctgcggcgt gctgctgctg     2520

agcctggtga tcaccctgta ctgcaggagt aagaggagca ggctcctgca cagtgactac     2580

atgaacatga ctccccgccg ccccgggccc acccgcaagc attaccagcc ctatgcccca     2640

ccacgcgact tcgcagccta tcgctccagg gtgaagttca gcaggagcgc cgacgccccc     2700

gcctaccagc agggccagaa ccagctgtac aacgagctga acctgggcag gagggaggag     2760

tacgacgtgc tggacaagag gaggggcagg gaccccgaga tgggcggcaa gcccaggagg     2820

aagaaccccc aggagggcct gtacaacgag ctgcagaagg acaagatggc cgaggcctac     2880

agcgagatcg gcatgaaggg cgagaggagg aggggcaagg gccacgacgg cctgtaccag     2940

ggcctgagca ccgccaccaa ggacacctac gacgccctgc acatgcaggc cctgcccccc     3000

aggtaagttt aaac                                                       3014


<210>  168
<211>  379
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  (FcER1A-28-2G CAR amino acid sequence)

<400>  168

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Val Pro Gln Lys Pro Lys Val Ser Leu Asn Pro 
            20                  25                  30          


Pro Trp Asn Arg Ile Phe Lys Gly Glu Asn Val Thr Leu Thr Cys Asn 
        35                  40                  45              


Gly Asn Asn Phe Phe Glu Val Ser Ser Thr Lys Trp Phe His Asn Gly 
    50                  55                  60                  


Ser Leu Ser Glu Glu Thr Asn Ser Ser Leu Asn Ile Val Asn Ala Lys 
65                  70                  75                  80  


Phe Glu Asp Ser Gly Glu Tyr Lys Cys Gln His Gln Gln Val Asn Glu 
                85                  90                  95      


Ser Glu Pro Val Tyr Leu Glu Val Phe Ser Asp Trp Leu Leu Leu Gln 
            100                 105                 110         


Ala Ser Ala Glu Val Val Met Glu Gly Gln Pro Leu Phe Leu Arg Cys 
        115                 120                 125             


His Gly Trp Arg Asn Trp Asp Val Tyr Lys Val Ile Tyr Tyr Lys Asp 
    130                 135                 140                 


Gly Glu Ala Leu Lys Tyr Trp Tyr Glu Asn His Asn Ile Ser Ile Thr 
145                 150                 155                 160 


Asn Ala Thr Val Glu Asp Ser Gly Thr Tyr Tyr Cys Thr Gly Lys Val 
                165                 170                 175     


Trp Gln Leu Asp Tyr Glu Ser Glu Pro Leu Asn Ile Thr Val Ile Lys 
            180                 185                 190         


Ala Pro Arg Glu Lys Tyr Trp Leu Gln Ile Tyr Ile Trp Ala Pro Leu 
        195                 200                 205             


Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr 
    210                 215                 220                 


Cys Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met 
225                 230                 235                 240 


Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala 
                245                 250                 255     


Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Arg Val Lys Phe Ser Arg 
            260                 265                 270         


Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn 
        275                 280                 285             


Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg 
    290                 295                 300                 


Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Gln Arg Arg Lys Asn 
305                 310                 315                 320 


Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu 
                325                 330                 335     


Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly 
            340                 345                 350         


His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr 
        355                 360                 365             


Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
    370                 375                 


<210>  169
<211>  1148
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  (FcER1A-28-2G CAR nucleotide sequence)

<400>  169
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccggtgcccc agaagcccaa ggtgagcctg aaccccccct ggaacaggat cttcaagggc      120

gagaacgtga ccctgacctg caacggcaac aacttcttcg aggtgagcag caccaagtgg      180

ttccacaacg gcagcctgag cgaggagacc aacagcagcc tgaacatcgt gaacgccaag      240

ttcgaggaca gcggcgagta caagtgccag caccagcagg tgaacgagag cgagcccgtg      300

tacctggagg tgttcagcga ctggctgctg ctgcaggcca gcgccgaggt ggtgatggag      360

ggccagcccc tgttcctgag gtgccacggc tggaggaact gggacgtgta caaggtgatc      420

tactacaagg acggcgaggc cctgaagtac tggtacgaga accacaacat cagcatcacc      480

aacgccaccg tggaggacag cggcacctac tactgcaccg gcaaggtgtg gcagctggac      540

tacgagagcg agcccctgaa catcaccgtg atcaaggccc ccagggagaa gtactggctg      600

cagatctaca tctgggcgcc cttggccggg acttgtgggg tccttctcct gtcactggtt      660

atcacccttt actgcaggag taagaggagc aggctcctgc acagtgacta catgaacatg      720

actccccgcc gccccgggcc cacccgcaag cattaccagc cctatgcccc accacgcgac      780

ttcgcagcct atcgctccag agtgaagttc agcaggagcg cagacgcccc cgcgtaccag      840

cagggccaga accagctcta taacgagctc aatctaggac gaagagagga gtacgatgtt      900

ttggacaaga gacgtggccg ggaccctgag atggggggaa agccgcagag aaggaagaac      960

cctcaggaag gcctgtacaa tgaactgcag aaagataaga tggcggaggc ctacagtgag     1020

attgggatga aaggcgagcg ccggaggggc aaggggcacg atggccttta ccagggtctc     1080

agtacagcca ccaaggacac ctacgacgcc cttcacatgc aggccctgcc ccctcgctaa     1140

gtttaaac                                                              1148


<210>  170
<211>  654
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  (FcER1A-28-4-1BBL CAR amino acid sequence)

<400>  170

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Val Pro Gln Lys Pro Lys Val Ser Leu Asn Pro 
            20                  25                  30          


Pro Trp Asn Arg Ile Phe Lys Gly Glu Asn Val Thr Leu Thr Cys Asn 
        35                  40                  45              


Gly Asn Asn Phe Phe Glu Val Ser Ser Thr Lys Trp Phe His Asn Gly 
    50                  55                  60                  


Ser Leu Ser Glu Glu Thr Asn Ser Ser Leu Asn Ile Val Asn Ala Lys 
65                  70                  75                  80  


Phe Glu Asp Ser Gly Glu Tyr Lys Cys Gln His Gln Gln Val Asn Glu 
                85                  90                  95      


Ser Glu Pro Val Tyr Leu Glu Val Phe Ser Asp Trp Leu Leu Leu Gln 
            100                 105                 110         


Ala Ser Ala Glu Val Val Met Glu Gly Gln Pro Leu Phe Leu Arg Cys 
        115                 120                 125             


His Gly Trp Arg Asn Trp Asp Val Tyr Lys Val Ile Tyr Tyr Lys Asp 
    130                 135                 140                 


Gly Glu Ala Leu Lys Tyr Trp Tyr Glu Asn His Asn Ile Ser Ile Thr 
145                 150                 155                 160 


Asn Ala Thr Val Glu Asp Ser Gly Thr Tyr Tyr Cys Thr Gly Lys Val 
                165                 170                 175     


Trp Gln Leu Asp Tyr Glu Ser Glu Pro Leu Asn Ile Thr Val Ile Lys 
            180                 185                 190         


Ala Pro Arg Glu Lys Tyr Trp Leu Gln Ile Tyr Ile Trp Ala Pro Leu 
        195                 200                 205             


Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr 
    210                 215                 220                 


Cys Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met 
225                 230                 235                 240 


Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala 
                245                 250                 255     


Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Arg Val Lys Phe Ser Arg 
            260                 265                 270         


Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn 
        275                 280                 285             


Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg 
    290                 295                 300                 


Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Gln Arg Arg Lys Asn 
305                 310                 315                 320 


Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu 
                325                 330                 335     


Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly 
            340                 345                 350         


His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr 
        355                 360                 365             


Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg Gly Ser Gly Glu Gly 
    370                 375                 380                 


Arg Gly Ser Leu Leu Thr Cys Gly Asp Val Glu Glu Asn Pro Gly Pro 
385                 390                 395                 400 


Met Glu Tyr Ala Ser Asp Ala Ser Leu Asp Pro Glu Ala Pro Trp Pro 
                405                 410                 415     


Pro Ala Pro Arg Ala Arg Ala Cys Arg Val Leu Pro Trp Ala Leu Val 
            420                 425                 430         


Ala Gly Leu Leu Leu Leu Leu Leu Leu Ala Ala Ala Cys Ala Val Phe 
        435                 440                 445             


Leu Ala Cys Pro Trp Ala Val Ser Gly Ala Arg Ala Ser Pro Gly Ser 
    450                 455                 460                 


Ala Ala Ser Pro Arg Leu Arg Glu Gly Pro Glu Leu Ser Pro Asp Asp 
465                 470                 475                 480 


Pro Ala Gly Leu Leu Asp Leu Arg Gln Gly Met Phe Ala Gln Leu Val 
                485                 490                 495     


Ala Gln Asn Val Leu Leu Ile Asp Gly Pro Leu Ser Trp Tyr Ser Asp 
            500                 505                 510         


Pro Gly Leu Ala Gly Val Ser Leu Thr Gly Gly Leu Ser Tyr Lys Glu 
        515                 520                 525             


Asp Thr Lys Glu Leu Val Val Ala Lys Ala Gly Val Tyr Tyr Val Phe 
    530                 535                 540                 


Phe Gln Leu Glu Leu Arg Arg Val Val Ala Gly Glu Gly Ser Gly Ser 
545                 550                 555                 560 


Val Ser Leu Ala Leu His Leu Gln Pro Leu Arg Ser Ala Ala Gly Ala 
                565                 570                 575     


Ala Ala Leu Ala Leu Thr Val Asp Leu Pro Pro Ala Ser Ser Glu Ala 
            580                 585                 590         


Arg Asn Ser Ala Phe Gly Phe Gln Gly Arg Leu Leu His Leu Ser Ala 
        595                 600                 605             


Gly Gln Arg Leu Gly Val His Leu His Thr Glu Ala Arg Ala Arg His 
    610                 615                 620                 


Ala Trp Gln Leu Thr Gln Gly Ala Thr Val Leu Gly Leu Phe Arg Val 
625                 630                 635                 640 


Thr Pro Glu Ile Pro Ala Gly Leu Pro Ser Pro Arg Ser Glu 
                645                 650                 


<210>  171
<211>  1973
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  (FcER1A-28-4-1BBL CAR nucleotide sequence)

<400>  171
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccggtgcccc agaagcccaa ggtgagcctg aaccccccct ggaacaggat cttcaagggc      120

gagaacgtga ccctgacctg caacggcaac aacttcttcg aggtgagcag caccaagtgg      180

ttccacaacg gcagcctgag cgaggagacc aacagcagcc tgaacatcgt gaacgccaag      240

ttcgaggaca gcggcgagta caagtgccag caccagcagg tgaacgagag cgagcccgtg      300

tacctggagg tgttcagcga ctggctgctg ctgcaggcca gcgccgaggt ggtgatggag      360

ggccagcccc tgttcctgag gtgccacggc tggaggaact gggacgtgta caaggtgatc      420

tactacaagg acggcgaggc cctgaagtac tggtacgaga accacaacat cagcatcacc      480

aacgccaccg tggaggacag cggcacctac tactgcaccg gcaaggtgtg gcagctggac      540

tacgagagcg agcccctgaa catcaccgtg atcaaggccc ccagggagaa gtactggctg      600

cagatctaca tctgggcgcc cttggccggg acttgtgggg tccttctcct gtcactggtt      660

atcacccttt actgcaggag taagaggagc aggctcctgc acagtgacta catgaacatg      720

actccccgcc gccccgggcc cacccgcaag cattaccagc cctatgcccc accacgcgac      780

ttcgcagcct atcgctccag agtgaagttc agcaggagcg cagacgcccc cgcgtaccag      840

cagggccaga accagctcta taacgagctc aatctaggac gaagagagga gtacgatgtt      900

ttggacaaga gacgtggccg ggaccctgag atggggggaa agccgcagag aaggaagaac      960

cctcaggaag gcctgtacaa tgaactgcag aaagataaga tggcggaggc ctacagtgag     1020

attgggatga aaggcgagcg ccggaggggc aaggggcacg atggccttta ccagggtctc     1080

agtacagcca ccaaggacac ctacgacgcc cttcacatgc aggccctgcc ccctcgcggc     1140

agcggcgaag gccgcggcag cctgctgacc tgcggcgatg tggaagaaaa cccgggcccc     1200

atggaatacg cctctgacgc ttcactggac cccgaagccc cgtggcctcc cgcgccccgc     1260

gctcgcgcct gccgcgtact gccttgggcc ctggtcgcgg ggctgctgct gctgctgctg     1320

ctcgctgccg cctgcgccgt cttcctcgcc tgcccctggg ccgtgtccgg ggctcgcgcc     1380

tcgcccggct ccgcggccag cccgagactc cgcgagggtc ccgagctttc gcccgacgat     1440

cccgccggcc tcttggacct gcggcagggc atgtttgcgc agctggtggc ccaaaatgtt     1500

ctgctgatcg atgggcccct gagctggtac agtgacccag gcctggcagg cgtgtccctg     1560

acggggggcc tgagctacaa agaggacacg aaggagctgg tggtggccaa ggctggagtc     1620

tactatgtct tctttcaact agagctgcgg cgcgtggtgg ccggcgaggg ctcaggctcc     1680

gtttcacttg cgctgcacct gcagccactg cgctctgctg ctggggccgc cgccctggct     1740

ttgaccgtgg acctgccacc cgcctcctcc gaggctcgga actcggcctt cggtttccag     1800

ggccgcttgc tgcacctgag tgccggccag cgcctgggcg tccatcttca cactgaggcc     1860

agggcacgcc atgcctggca gcttacccag ggcgccacag tcttgggact cttccgggtg     1920

acccccgaaa tcccagccgg actcccttca ccgaggtcgg aataagttta aac            1973


<210>  172
<211>  1007
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  (CD19b-BAFFR sequence CAR amino acid sequence)

<400>  172

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu 
            20                  25                  30          


Ile Lys Pro Gly Ala Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr 
        35                  40                  45              


Thr Phe Thr Ser Tyr Val Met His Trp Val Lys Gln Lys Pro Gly Gln 
    50                  55                  60                  


Gly Leu Glu Trp Ile Gly Tyr Ile Asn Pro Tyr Asn Asp Gly Thr Lys 
65                  70                  75                  80  


Tyr Asn Glu Lys Phe Lys Gly Lys Ala Thr Leu Thr Ser Asp Lys Ser 
                85                  90                  95      


Ser Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Thr Ser Glu Asp Ser 
            100                 105                 110         


Ala Val Tyr Tyr Cys Ala Arg Gly Thr Tyr Tyr Tyr Gly Ser Arg Val 
        115                 120                 125             


Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val 
145                 150                 155                 160 


Met Thr Gln Ala Ala Pro Ser Ile Pro Val Thr Pro Gly Glu Ser Val 
                165                 170                 175     


Ser Ile Ser Cys Arg Ser Ser Lys Ser Leu Leu Asn Ser Asn Gly Asn 
            180                 185                 190         


Thr Tyr Leu Tyr Trp Phe Leu Gln Arg Pro Gly Gln Ser Pro Gln Leu 
        195                 200                 205             


Leu Ile Tyr Arg Met Ser Asn Leu Ala Ser Gly Val Pro Asp Arg Phe 
    210                 215                 220                 


Ser Gly Ser Gly Ser Gly Thr Ala Phe Thr Leu Arg Ile Ser Arg Val 
225                 230                 235                 240 


Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln His Leu Glu Tyr 
                245                 250                 255     


Pro Phe Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Arg Thr Thr 
            260                 265                 270         


Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln 
        275                 280                 285             


Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala 
    290                 295                 300                 


Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala 
305                 310                 315                 320 


Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr 
                325                 330                 335     


Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln 
            340                 345                 350         


Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser 
        355                 360                 365             


Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys 
    370                 375                 380                 


Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln 
385                 390                 395                 400 


Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu 
                405                 410                 415     


Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Gln Arg 
            420                 425                 430         


Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys 
        435                 440                 445             


Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg 
    450                 455                 460                 


Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys 
465                 470                 475                 480 


Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg Gly Ser 
                485                 490                 495     


Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu 
            500                 505                 510         


Asn Pro Gly Pro Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu 
        515                 520                 525             


Ala Leu Leu Leu His Ala Ala Arg Pro Gln Val Gln Leu Gln Gln Ser 
    530                 535                 540                 


Gly Pro Gly Leu Val Lys Pro Ser Gln Thr Leu Ser Leu Ile Cys Ala 
545                 550                 555                 560 


Ile Ser Gly Asp Ser Val Ser Ser Asn Ser Ala Ala Trp Gly Trp Ile 
                565                 570                 575     


Arg Gln Ser Pro Gly Arg Gly Leu Glu Trp Leu Gly Arg Ile Tyr Tyr 
            580                 585                 590         


Arg Ser Lys Trp Tyr Asn Ser Tyr Ala Val Ser Val Lys Ser Arg Ile 
        595                 600                 605             


Thr Ile Asn Pro Asp Thr Ser Lys Asn Gln Phe Ser Leu Gln Leu Asn 
    610                 615                 620                 


Ser Val Thr Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Tyr Asp 
625                 630                 635                 640 


Trp Val Pro Lys Ile Gly Val Phe Asp Ser Trp Gly Gln Gly Thr Leu 
                645                 650                 655     


Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
            660                 665                 670         


Gly Gly Gly Ser Asp Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser 
        675                 680                 685             


Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Phe 
    690                 695                 700                 


Ile Ser Ser Ser Tyr Leu Ser Trp Tyr Gln Gln Lys Pro Gly Gln Ala 
705                 710                 715                 720 


Pro Arg Leu Leu Ile Tyr Gly Ser Ser Ser Arg Ala Thr Gly Val Pro 
                725                 730                 735     


Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile 
            740                 745                 750         


Ser Ser Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Leu 
        755                 760                 765             


Tyr Ser Ser Pro Met Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
    770                 775                 780                 


Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala 
785                 790                 795                 800 


Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly 
                805                 810                 815     


Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile 
            820                 825                 830         


Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val 
        835                 840                 845             


Ile Thr Leu Tyr Cys Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp 
    850                 855                 860                 


Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr 
865                 870                 875                 880 


Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Arg Val 
                885                 890                 895     


Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn 
            900                 905                 910         


Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val 
        915                 920                 925             


Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Gln 
    930                 935                 940                 


Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp 
945                 950                 955                 960 


Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg 
                965                 970                 975     


Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr 
            980                 985                 990         


Lys Asp Thr Tyr Asp Ala Leu His  Met Gln Ala Leu Pro  Pro Arg 
        995                 1000                 1005         


<210>  173
<211>  3040
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  (CD19b-BAFFR CAR nucleotide sequence)

<400>  173
gcgatcgcat ggccttacca gtgaccgcct tgctcctgcc gctggccttg ctgctccacg       60

ccgccaggcc ggaggtccag ctgcagcagt ctggacctga gctgataaag cctggggctt      120

cagtgaagat gtcctgcaag gcttctggat acacattcac tagctatgtt atgcactggg      180

tgaagcagaa gcctgggcag ggccttgagt ggattggata tattaatcct tacaatgatg      240

gtactaagta caatgagaag ttcaaaggca aggccacact gacttcagac aaatcctcca      300

gcacagccta catggagctc agcagcctga cctctgagga ctctgcggtc tattactgtg      360

caagagggac ttattactac ggtagtaggg tatttgacta ctggggccaa ggcaccactc      420

tcacagtctc ctcaggtgga gggggctcag gcggaggtgg ctctgggggt ggaggctcgg      480

acattgtgat gactcaggct gcaccctcta tacctgtcac tcctggagag tcagtatcca      540

tctcctgcag gtctagtaag agtctcctga atagtaatgg caacacttac ttgtattggt      600

tcctgcagag gccaggccag tctcctcagc tcctgatata tcggatgtcc aaccttgcct      660

caggagtccc agacaggttc agtggcagtg ggtcaggaac tgctttcaca ctgagaatca      720

gtagagtgga ggctgaggat gtgggtgttt attactgtat gcaacatcta gaatatccgt      780

tcacgttcgg tgctgggacc aagctggagc tgaaacggac cacgacgcca gcgccgcgac      840

caccaacacc ggcgcccacc atcgcgtcgc agcccctgtc cctgcgccca gaggcgtgcc      900

ggccagcggc ggggggcgca gtgcacacga gggggctgga cttcgcctgt gatatctaca      960

tctgggcgcc cttggccggg acttgtgggg tccttctcct gtcactggtt atcacccttt     1020

actgcaaacg gggcagaaag aaactcctgt atatattcaa acaaccattt atgagaccag     1080

tacaaactac tcaagaggaa gatggctgta gctgccgatt tccagaagaa gaagaaggag     1140

gatgtgaact gagagtgaag ttcagcagga gcgcagacgc ccccgcgtac cagcagggcc     1200

agaaccagct ctataacgag ctcaatctag gacgaagaga ggagtacgat gttttggaca     1260

agagacgtgg ccgggaccct gagatggggg gaaagccgca gagaaggaag aaccctcagg     1320

aaggcctgta caatgaactg cagaaagata agatggcgga ggcctacagt gagattggga     1380

tgaaaggcga gcgccggagg ggcaaggggc acgatggcct ttaccagggt ctcagtacag     1440

ccaccaagga cacctacgac gcccttcaca tgcaggccct gccccctcgc ggaagcggag     1500

ccaccaactt cagcctgctg aagcaggccg gcgacgtgga ggagaacccc ggccccatgg     1560

ccctgcccgt gaccgccctg ctgctgcccc tggccctgct gctgcacgcc gccaggcccc     1620

aggtgcagct gcagcagagc ggcccaggcc tggtcaagcc ctctcagacc ctgtcactga     1680

tctgcgccat ttcaggcgac agcgtgagca gcaacagcgc cgcctggggc tggatcaggc     1740

agagccccgg taggggcctg gaatggctgg gcaggatcta ctacaggtcc aagtggtaca     1800

acagctacgc cgtgagcgtg aagagcagga tcaccatcaa ccctgacacc agcaagaacc     1860

agttctcact gcagctcaac agcgtgaccc ccgaggacac cgccgtgtac tactgcgcca     1920

gatacgactg ggtgcccaag atcggcgtgt tcgacagctg gggccagggc accctggtga     1980

ccgtgtcaag cggagggggg ggatccgggg gaggaggctc cggcggaggc ggaagcgata     2040

tcgtgctgac acagagcccc gccaccctga gcctgagccc aggcgagagg gccaccctgt     2100

cctgcagggc cagccagttt atcagcagca gctacctgtc ctggtatcag cagaagcccg     2160

gccaggcccc tagactgctg atctacggca gctcctctcg ggccaccggc gtgcccgcca     2220

ggttcagcgg cagcggctcc ggcaccgact tcaccctgac aatcagcagc ctggagcccg     2280

aggacttcgc cgtgtactac tgccagcagc tgtacagctc acccatgacc ttcggccagg     2340

gcaccaaggt ggagatcaag accaccaccc ccgcccccag gccccccacc cccgccccca     2400

ccatcgccag ccagcccctg agcctgaggc ccgaggcctg caggcccgcc gccggcggcg     2460

ccgtgcacac caggggcctg gacttcgcct gcgacatcta catctgggcc cccctggccg     2520

gcacctgcgg cgtgctgctg ctgagcctgg tgatcaccct gtactgcagg agtaagagga     2580

gcaggctcct gcacagtgac tacatgaaca tgactccccg ccgccccggg cccacccgca     2640

agcattacca gccctatgcc ccaccacgcg acttcgcagc ctatcgctcc agggtgaagt     2700

tcagcaggag cgccgacgcc cccgcctacc agcagggcca gaaccagctg tacaacgagc     2760

tgaacctggg caggagggag gagtacgacg tgctggacaa gaggaggggc agggaccccg     2820

agatgggcgg caagccccag aggaggaaga acccccagga gggcctgtac aacgagctgc     2880

agaaggacaa gatggccgag gcctacagcg agatcggcat gaagggcgag aggaggaggg     2940

gcaagggcca cgacggcctg taccagggcc tgagcaccgc caccaaggac acctacgacg     3000

ccctgcacat gcaggccctg ccccccaggt aagtttaaac                           3040


<210>  174
<211>  789
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  (CD19b-BB-IL-15/IL-15sushi CAR amino acid sequence)

<400>  174

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu 
            20                  25                  30          


Ile Lys Pro Gly Ala Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr 
        35                  40                  45              


Thr Phe Thr Ser Tyr Val Met His Trp Val Lys Gln Lys Pro Gly Gln 
    50                  55                  60                  


Gly Leu Glu Trp Ile Gly Tyr Ile Asn Pro Tyr Asn Asp Gly Thr Lys 
65                  70                  75                  80  


Tyr Asn Glu Lys Phe Lys Gly Lys Ala Thr Leu Thr Ser Asp Lys Ser 
                85                  90                  95      


Ser Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Thr Ser Glu Asp Ser 
            100                 105                 110         


Ala Val Tyr Tyr Cys Ala Arg Gly Thr Tyr Tyr Tyr Gly Ser Arg Val 
        115                 120                 125             


Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val 
145                 150                 155                 160 


Met Thr Gln Ala Ala Pro Ser Ile Pro Val Thr Pro Gly Glu Ser Val 
                165                 170                 175     


Ser Ile Ser Cys Arg Ser Ser Lys Ser Leu Leu Asn Ser Asn Gly Asn 
            180                 185                 190         


Thr Tyr Leu Tyr Trp Phe Leu Gln Arg Pro Gly Gln Ser Pro Gln Leu 
        195                 200                 205             


Leu Ile Tyr Arg Met Ser Asn Leu Ala Ser Gly Val Pro Asp Arg Phe 
    210                 215                 220                 


Ser Gly Ser Gly Ser Gly Thr Ala Phe Thr Leu Arg Ile Ser Arg Val 
225                 230                 235                 240 


Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln His Leu Glu Tyr 
                245                 250                 255     


Pro Phe Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Arg Thr Thr 
            260                 265                 270         


Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln 
        275                 280                 285             


Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala 
    290                 295                 300                 


Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala 
305                 310                 315                 320 


Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr 
                325                 330                 335     


Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln 
            340                 345                 350         


Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser 
        355                 360                 365             


Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys 
    370                 375                 380                 


Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln 
385                 390                 395                 400 


Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu 
                405                 410                 415     


Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Gln Arg 
            420                 425                 430         


Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys 
        435                 440                 445             


Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg 
    450                 455                 460                 


Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys 
465                 470                 475                 480 


Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg Gly Ser 
                485                 490                 495     


Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu 
            500                 505                 510         


Asn Pro Gly Pro Met Tyr Arg Met Gln Leu Leu Ser Cys Ile Ala Leu 
        515                 520                 525             


Ser Leu Ala Leu Val Thr Asn Ser Gly Ile His Val Phe Ile Leu Gly 
    530                 535                 540                 


Cys Phe Ser Ala Gly Leu Pro Lys Thr Glu Ala Asn Trp Val Asn Val 
545                 550                 555                 560 


Ile Ser Asp Leu Lys Lys Ile Glu Asp Leu Ile Gln Ser Met His Ile 
                565                 570                 575     


Asp Ala Thr Leu Tyr Thr Glu Ser Asp Val His Pro Ser Cys Lys Val 
            580                 585                 590         


Thr Ala Met Lys Cys Phe Leu Leu Glu Leu Gln Val Ile Ser Leu Glu 
        595                 600                 605             


Ser Gly Asp Ala Ser Ile His Asp Thr Val Glu Asn Leu Ile Ile Leu 
    610                 615                 620                 


Ala Asn Asn Ser Leu Ser Ser Asn Gly Asn Val Thr Glu Ser Gly Cys 
625                 630                 635                 640 


Lys Glu Cys Glu Glu Leu Glu Glu Lys Asn Ile Lys Glu Phe Leu Gln 
                645                 650                 655     


Ser Phe Val His Ile Val Gln Met Phe Ile Asn Thr Ser Ser Gly Gly 
            660                 665                 670         


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        675                 680                 685             


Ser Gly Gly Gly Ser Leu Gln Ala Pro Arg Arg Ala Arg Gly Cys Arg 
    690                 695                 700                 


Thr Leu Gly Leu Pro Ala Leu Leu Leu Leu Leu Leu Leu Arg Pro Pro 
705                 710                 715                 720 


Ala Thr Arg Gly Ile Thr Cys Pro Pro Pro Met Ser Val Glu His Ala 
                725                 730                 735     


Asp Ile Trp Val Lys Ser Tyr Ser Leu Tyr Ser Arg Glu Arg Tyr Ile 
            740                 745                 750         


Cys Asn Ser Gly Phe Lys Arg Lys Ala Gly Thr Ser Ser Leu Thr Glu 
        755                 760                 765             


Cys Val Leu Asn Lys Ala Thr Asn Val Ala His Trp Thr Thr Pro Ser 
    770                 775                 780                 


Leu Lys Cys Ile Arg 
785                 


<210>  175
<211>  2378
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  (CD19b-BB-IL-15/IL-15sushi CAR nucleotide sequence)

<400>  175
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccggaggtcc agctgcagca gtctggacct gagctgataa agcctggggc ttcagtgaag      120

atgtcctgca aggcttctgg atacacattc actagctatg ttatgcactg ggtgaagcag      180

aagcctgggc agggccttga gtggattgga tatattaatc cttacaatga tggtactaag      240

tacaatgaga agttcaaagg caaggccaca ctgacttcag acaaatcctc cagcacagcc      300

tacatggagc tcagcagcct gacctctgag gactctgcgg tctattactg tgcaagaggg      360

acttattact acggtagtag ggtatttgac tactggggcc aaggcaccac tctcacagtc      420

tcctcaggtg gagggggctc aggcggaggt ggctctgggg gtggaggctc ggacattgtg      480

atgactcagg ctgcaccctc tatacctgtc actcctggag agtcagtatc catctcctgc      540

aggtctagta agagtctcct gaatagtaat ggcaacactt acttgtattg gttcctgcag      600

aggccaggcc agtctcctca gctcctgata tatcggatgt ccaaccttgc ctcaggagtc      660

ccagacaggt tcagtggcag tgggtcagga actgctttca cactgagaat cagtagagtg      720

gaggctgagg atgtgggtgt ttattactgt atgcaacatc tagaatatcc gttcacgttc      780

ggtgctggga ccaagctgga gctgaaacgg accacgacgc cagcgccgcg accaccaaca      840

ccggcgccca ccatcgcgtc gcagcccctg tccctgcgcc cagaggcgtg ccggccagcg      900

gcggggggcg cagtgcacac gagggggctg gacttcgcct gtgatatcta catctgggcg      960

cccttggccg ggacttgtgg ggtccttctc ctgtcactgg ttatcaccct ttactgcaaa     1020

cggggcagaa agaaactcct gtatatattc aaacaaccat ttatgagacc agtacaaact     1080

actcaagagg aagatggctg tagctgccga tttccagaag aagaagaagg aggatgtgaa     1140

ctgagagtga agttcagcag gagcgcagac gcccccgcgt accagcaggg ccagaaccag     1200

ctctataacg agctcaatct aggacgaaga gaggagtacg atgttttgga caagagacgt     1260

ggccgggacc ctgagatggg gggaaagccg cagagaagga agaaccctca ggaaggcctg     1320

tacaatgaac tgcagaaaga taagatggcg gaggcctaca gtgagattgg gatgaaaggc     1380

gagcgccgga ggggcaaggg gcacgatggc ctttaccagg gtctcagtac agccaccaag     1440

gacacctacg acgcccttca catgcaggcc ctgccccctc gcggaagcgg agccaccaac     1500

ttcagcctgc tgaagcaggc cggcgacgtg gaggagaacc ccggccccat gtacagaatg     1560

cagctgctga gctgcatcgc cctgagcctg gccctggtga ccaacagcgg catccacgtg     1620

ttcatcctgg gctgcttcag cgccggcctg cccaagaccg aggccaactg ggtgaacgtg     1680

atcagcgacc tgaagaagat cgaggacctg atccagagca tgcacatcga cgccaccctg     1740

tacaccgaga gcgacgtgca ccccagctgc aaggtgaccg ccatgaagtg cttcctgctg     1800

gagctgcagg tgatcagcct ggagagcggc gacgccagca tccacgacac cgtggagaac     1860

ctgatcatcc tggccaacaa cagcctgagc agcaacggca acgtgaccga gagcggctgc     1920

aaggagtgcg aggagctgga ggagaagaac atcaaggagt tcctgcagag cttcgtgcac     1980

atcgtgcaga tgttcatcaa caccagctcc ggcggcggct ccggcggcgg cggctccggc     2040

ggcggcggct ccggcggcgg cggctccggc ggcggctccc tgcaggcccc cagaagagcc     2100

agaggctgca gaaccctggg cctgcccgcc ctgctgctgc tgctgctgct gagacccccc     2160

gccaccagag gcatcacctg cccccccccc atgagcgtgg agcacgccga catctgggtg     2220

aagagctaca gcctgtacag cagagagaga tacatctgca acagcggctt caagagaaag     2280

gccggcacca gcagcctgac cgagtgcgtg ctgaacaagg ccaccaacgt ggcccactgg     2340

accaccccca gcctgaagtg catcagataa gtttaaac                             2378


<210>  176
<211>  488
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  (BCMA-A7D-28-2G, CD269-A7D-28-2G CAR amino acid sequence)

<400>  176

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Asp Val Val Met Thr Gln Ser His Arg Phe Met 
            20                  25                  30          


Ser Thr Ser Val Gly Asp Arg Val Ser Ile Thr Cys Arg Ala Ser Gln 
        35                  40                  45              


Asp Val Asn Thr Ala Val Ser Trp Tyr Gln Gln Lys Pro Gly Gln Ser 
    50                  55                  60                  


Pro Lys Leu Leu Ile Phe Ser Ala Ser Tyr Arg Tyr Thr Gly Val Pro 
65                  70                  75                  80  


Asp Arg Phe Thr Gly Ser Gly Ser Gly Ala Asp Phe Thr Leu Thr Ile 
                85                  90                  95      


Ser Ser Val Gln Ala Glu Asp Leu Ala Val Tyr Tyr Cys Gln Gln His 
            100                 105                 110         


Tyr Ser Thr Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Asp Ile Lys 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln 
    130                 135                 140                 


Ile Gln Leu Val Gln Ser Gly Pro Asp Leu Lys Lys Pro Gly Glu Thr 
145                 150                 155                 160 


Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Phe Gly 
                165                 170                 175     


Met Asn Trp Val Lys Gln Ala Pro Gly Lys Gly Phe Lys Trp Met Ala 
            180                 185                 190         


Trp Ile Asn Thr Tyr Thr Gly Glu Ser Tyr Phe Ala Asp Asp Phe Lys 
        195                 200                 205             


Gly Arg Phe Ala Phe Ser Val Glu Thr Ser Ala Thr Thr Ala Tyr Leu 
    210                 215                 220                 


Gln Ile Asn Asn Leu Lys Thr Glu Asp Thr Ala Thr Tyr Phe Cys Ala 
225                 230                 235                 240 


Arg Gly Glu Ile Tyr Tyr Gly Tyr Asp Gly Gly Phe Ala Tyr Trp Gly 
                245                 250                 255     


Gln Gly Thr Leu Val Thr Val Ser Ala Thr Thr Thr Pro Ala Pro Arg 
            260                 265                 270         


Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg 
        275                 280                 285             


Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly 
    290                 295                 300                 


Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr 
305                 310                 315                 320 


Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Arg Ser 
                325                 330                 335     


Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg 
            340                 345                 350         


Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg 
        355                 360                 365             


Asp Phe Ala Ala Tyr Arg Ser Arg Val Lys Phe Ser Arg Ser Ala Asp 
    370                 375                 380                 


Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn 
385                 390                 395                 400 


Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg 
                405                 410                 415     


Asp Pro Glu Met Gly Gly Lys Pro Gln Arg Arg Lys Asn Pro Gln Glu 
            420                 425                 430         


Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser 
        435                 440                 445             


Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly 
    450                 455                 460                 


Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu 
465                 470                 475                 480 


His Met Gln Ala Leu Pro Pro Arg 
                485             


<210>  177
<211>  1475
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  (BCMA-A7D-28-2G, CD269-A7D-28-2G CAR nucleotide sequence)

<400>  177
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccggacgtgg tgatgaccca gagccacagg ttcatgagca ccagcgtggg cgacagggtg      120

agcatcacct gcagggccag ccaggacgtg aacaccgccg tgagctggta ccagcagaag      180

cccggccaga gccccaagct gctgatcttc agcgccagct acaggtacac cggcgtgccc      240

gacaggttca ccggcagcgg cagcggcgcc gacttcaccc tgaccatcag cagcgtgcag      300

gccgaggacc tggccgtgta ctactgccag cagcactaca gcaccccctg gaccttcggc      360

ggcggcacca agctggacat caagggaggg gggggatccg ggggaggagg ctccggcgga      420

ggcggaagcc agatccagct ggtgcagagc ggccccgacc tgaagaagcc cggcgagacc      480

gtgaagctga gctgcaaggc cagcggctac accttcacca acttcggcat gaactgggtg      540

aagcaggccc ccggcaaggg cttcaagtgg atggcctgga tcaacaccta caccggcgag      600

agctacttcg ccgacgactt caagggcagg ttcgccttca gcgtggagac cagcgccacc      660

accgcctacc tgcagatcaa caacctgaag accgaggaca ccgccaccta cttctgcgcc      720

aggggcgaga tctactacgg ctacgacggc ggcttcgcct actggggcca gggcaccctg      780

gtgaccgtga gcgccaccac gacgccagcg ccgcgaccac caacaccggc gcccaccatc      840

gcgtcgcagc ccctgtccct gcgcccagag gcgtgccggc cagcggcggg gggcgcagtg      900

cacacgaggg ggctggactt cgcctgtgat atctacatct gggcgccctt ggccgggact      960

tgtggggtcc ttctcctgtc actggttatc accctttact gcaggagtaa gaggagcagg     1020

ctcctgcaca gtgactacat gaacatgact ccccgccgcc ccgggcccac ccgcaagcat     1080

taccagccct atgccccacc acgcgacttc gcagcctatc gctccagagt gaagttcagc     1140

aggagcgcag acgcccccgc gtaccagcag ggccagaacc agctctataa cgagctcaat     1200

ctaggacgaa gagaggagta cgatgttttg gacaagagac gtggccggga ccctgagatg     1260

gggggaaagc cgcagagaag gaagaaccct caggaaggcc tgtacaatga actgcagaaa     1320

gataagatgg cggaggccta cagtgagatt gggatgaaag gcgagcgccg gaggggcaag     1380

gggcacgatg gcctttacca gggtctcagt acagccacca aggacaccta cgacgccctt     1440

cacatgcagg ccctgccccc tcgctaagtt taaac                                1475


<210>  178
<211>  487
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  (BCMA-C11D-28, CD269-C11D-28 CAR amino acid sequence)

<400>  178

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Asp Ile Val Leu Thr Gln Ser Pro Pro Ser Leu 
            20                  25                  30          


Ala Met Ser Leu Gly Lys Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu 
        35                  40                  45              


Ser Val Thr Ile Leu Gly Ser His Leu Ile His Trp Tyr Gln Gln Lys 
    50                  55                  60                  


Pro Gly Gln Pro Pro Thr Leu Leu Ile Gln Leu Ala Ser Asn Val Gln 
65                  70                  75                  80  


Thr Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Arg Thr Asp Phe 
                85                  90                  95      


Thr Leu Thr Ile Asp Pro Val Glu Glu Asp Asp Val Ala Val Tyr Tyr 
            100                 105                 110         


Cys Leu Gln Ser Arg Thr Ile Pro Arg Thr Phe Gly Gly Gly Thr Lys 
        115                 120                 125             


Leu Glu Ile Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Gln Ile Gln Leu Val Gln Ser Gly Pro Glu Leu Lys Lys 
145                 150                 155                 160 


Pro Gly Glu Thr Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
                165                 170                 175     


Thr Asp Tyr Ser Ile Asn Trp Val Lys Arg Ala Pro Gly Lys Gly Leu 
            180                 185                 190         


Lys Trp Met Gly Trp Ile Asn Thr Glu Thr Arg Glu Pro Ala Tyr Ala 
        195                 200                 205             


Tyr Asp Phe Arg Gly Arg Phe Ala Phe Ser Leu Glu Thr Ser Ala Ser 
    210                 215                 220                 


Thr Ala Tyr Leu Gln Ile Asn Asn Leu Lys Tyr Glu Asp Thr Ala Thr 
225                 230                 235                 240 


Tyr Phe Cys Ala Leu Asp Tyr Ser Tyr Ala Met Asp Tyr Trp Gly Gln 
                245                 250                 255     


Gly Thr Ser Val Thr Val Ser Ser Thr Thr Thr Pro Ala Pro Arg Pro 
            260                 265                 270         


Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro 
        275                 280                 285             


Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu 
    290                 295                 300                 


Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys 
305                 310                 315                 320 


Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Arg Ser Lys 
                325                 330                 335     


Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg 
            340                 345                 350         


Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp 
        355                 360                 365             


Phe Ala Ala Tyr Arg Ser Arg Val Lys Phe Ser Arg Ser Ala Asp Ala 
    370                 375                 380                 


Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu 
385                 390                 395                 400 


Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp 
                405                 410                 415     


Pro Glu Met Gly Gly Lys Pro Gln Arg Arg Lys Asn Pro Gln Glu Gly 
            420                 425                 430         


Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu 
        435                 440                 445             


Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu 
    450                 455                 460                 


Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His 
465                 470                 475                 480 


Met Gln Ala Leu Pro Pro Arg 
                485         


<210>  179
<211>  1397
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  (BCMA-C11D-28, CD269-C11D-28 CAR nucleotide sequence)

<400>  179
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccggacatcg tgctgaccca gagccccccc agcctggcca tgagcctggg caagagggcc      120

accatcagct gcagggccag cgagagcgtg accatcctgg gcagccacct gatccactgg      180

taccagcaga agcccggcca gccccccacc ctgctgatcc agctggccag caacgtgcag      240

accggcgtgc ccgccaggtt cagcggcagc ggcagcagga ccgacttcac cctgaccatc      300

gaccccgtgg aggaggacga cgtggccgtg tactactgcc tgcagagcag gaccatcccc      360

aggaccttcg gcggcggcac caagctggag atcaagggag gggggggatc cgggggagga      420

ggctccggcg gaggcggaag ccagatccag ctggtgcaga gcggccccga gctgaagaag      480

cccggcgaga ccgtgaagat cagctgcaag gccagcggct acaccttcac cgactacagc      540

atcaactggg tgaagagggc ccccggcaag ggcctgaagt ggatgggctg gatcaacacc      600

gagaccaggg agcccgccta cgcctacgac ttcaggggca ggttcgcctt cagcctggag      660

accagcgcca gcaccgccta cctgcagatc aacaacctga agtacgagga caccgccacc      720

tacttctgcg ccctggacta cagctacgcc atggactact ggggccaggg caccagcgtg      780

accgtgagca gcaccacgac gccagcgccg cgaccaccaa caccggcgcc caccatcgcg      840

tcgcagcccc tgtccctgcg cccagaggcg tgccggccag cggcgggggg cgcagtgcac      900

acgagggggc tggacttcgc ctgtgatatc tacatctggg cgcccttggc cgggacttgt      960

ggggtccttc tcctgtcact ggttatcacc ctttactgca ggagtaagag gagcaggctc     1020

ctgcacagtg actacatgaa catgactccc cgccgccccg ggcccacccg caagcattac     1080

cagccctatg ccccaccacg cgacttcgca gcctatcgct ccagagtgaa gttcagcagg     1140

agcgcagacg cccccgcgta ccagcagggc cagaaccagc tctataacga gctcaatcta     1200

ggacgaagag aggagtacga tgttttggac aagagacgtg gccgggaccc tgagatgggg     1260

ggaaagccgc agagaaggaa gaaccctcag gaaggcctgt acaatgaact gcagaaagat     1320

aagatggcgg aggcctacag tgagattggg atgaaaggcg agcgccggag gggcaagggg     1380

cacgatggcc tttacca                                                    1397


<210>  180
<211>  484
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  (CS1-hu63-28-2G CAR amino acid sequence)

<400>  180

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu 
            20                  25                  30          


Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln 
        35                  40                  45              


Asp Val Gly Ile Ala Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Val 
    50                  55                  60                  


Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg His Thr Gly Val Pro 
65                  70                  75                  80  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile 
                85                  90                  95      


Ser Ser Leu Gln Pro Glu Asp Val Ala Thr Tyr Tyr Cys Gln Gln Tyr 
            100                 105                 110         


Ser Ser Tyr Pro Tyr Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu 
    130                 135                 140                 


Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser 
145                 150                 155                 160 


Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Phe Ser Arg Tyr Trp Met 
                165                 170                 175     


Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Gly Glu 
            180                 185                 190         


Ile Asn Pro Asp Ser Ser Thr Ile Asn Tyr Ala Pro Ser Leu Lys Asp 
        195                 200                 205             


Lys Phe Ile Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr Leu Gln 
    210                 215                 220                 


Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
225                 230                 235                 240 


Pro Asp Gly Asn Tyr Trp Tyr Phe Asp Val Trp Gly Gln Gly Thr Leu 
                245                 250                 255     


Val Thr Val Ser Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro 
            260                 265                 270         


Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys 
        275                 280                 285             


Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala 
    290                 295                 300                 


Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu 
305                 310                 315                 320 


Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Arg Ser Lys Arg Ser Arg 
                325                 330                 335     


Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro 
            340                 345                 350         


Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala 
        355                 360                 365             


Tyr Arg Ser Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr 
    370                 375                 380                 


Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg 
385                 390                 395                 400 


Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met 
                405                 410                 415     


Gly Gly Lys Pro Gln Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn 
            420                 425                 430         


Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met 
        435                 440                 445             


Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly 
    450                 455                 460                 


Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala 
465                 470                 475                 480 


Leu Pro Pro Arg 
                


<210>  181
<211>  1463
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  (CS1-hu63-28-2G CAR nucleotide sequence)

<400>  181
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccggacatcc agatgaccca gagccccagc agcctgagcg ccagcgtggg cgacagggtg      120

accatcacct gcaaggccag ccaggacgtg ggcatcgccg tggcctggta ccagcagaag      180

cccggcaagg tgcccaagct gctgatctac tgggccagca ccaggcacac cggcgtgccc      240

gacaggttca gcggcagcgg cagcggcacc gacttcaccc tgaccatcag cagcctgcag      300

cccgaggacg tggccaccta ctactgccag cagtacagca gctaccccta caccttcggc      360

cagggcacca aggtggagat caagggaggg gggggatccg ggggaggagg ctccggcgga      420

ggcggaagcg aggtgcagct ggtggagagc ggcggcggcc tggtgcagcc cggcggcagc      480

ctgaggctga gctgcgccgc cagcggcttc ttcagcaggt actggatgag ctgggtgagg      540

caggcccccg gcaagggcct ggagtggatc ggcgagatca accccgacag cagcaccatc      600

aactacgccc ccagcctgaa ggacaagttc atcatcagca gggacaacgc caagaacagc      660

ctgtacctgc agatgaacag cctgagggcc gaggacaccg ccgtgtacta ctgcgccagg      720

cccgacggca actactggta cttcgacgtg tggggccagg gcaccctggt gaccgtgagc      780

agcaccacga cgccagcgcc gcgaccacca acaccggcgc ccaccatcgc gtcgcagccc      840

ctgtccctgc gcccagaggc gtgccggcca gcggcggggg gcgcagtgca cacgaggggg      900

ctggacttcg cctgtgatat ctacatctgg gcgcccttgg ccgggacttg tggggtcctt      960

ctcctgtcac tggttatcac cctttactgc aggagtaaga ggagcaggct cctgcacagt     1020

gactacatga acatgactcc ccgccgcccc gggcccaccc gcaagcatta ccagccctat     1080

gccccaccac gcgacttcgc agcctatcgc tccagagtga agttcagcag gagcgcagac     1140

gcccccgcgt accagcaggg ccagaaccag ctctataacg agctcaatct aggacgaaga     1200

gaggagtacg atgttttgga caagagacgt ggccgggacc ctgagatggg gggaaagccg     1260

cagagaagga agaaccctca ggaaggcctg tacaatgaac tgcagaaaga taagatggcg     1320

gaggcctaca gtgagattgg gatgaaaggc gagcgccgga ggggcaaggg gcacgatggc     1380

ctttaccagg gtctcagtac agccaccaag gacacctacg acgcccttca catgcaggcc     1440

ctgccccctc gctaagttta aac                                             1463


<210>  182
<211>  487
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  (CS1-mu34-28-2G CAR amino acid sequence)

<400>  182

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Asp Ile Gln Met Thr Gln Ser Ser Ser Tyr Leu 
            20                  25                  30          


Ser Val Ser Leu Gly Gly Arg Val Thr Ile Thr Cys Lys Ala Ser Asp 
        35                  40                  45              


His Ile Asn Asn Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Asn Ala 
    50                  55                  60                  


Pro Arg Leu Leu Ile Ser Gly Ala Thr Ser Leu Glu Thr Gly Val Pro 
65                  70                  75                  80  


Ser Arg Phe Ser Gly Ser Gly Ser Gly Lys Asp Tyr Thr Leu Ser Ile 
                85                  90                  95      


Thr Ser Leu Gln Thr Glu Asp Val Ala Thr Tyr Tyr Cys Gln Gln Tyr 
            100                 105                 110         


Trp Ser Thr Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln 
    130                 135                 140                 


Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Ala Arg Pro Gly Ala Ser 
145                 150                 155                 160 


Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr Trp 
                165                 170                 175     


Met Gln Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile Gly 
            180                 185                 190         


Ala Ile Tyr Pro Gly Asp Gly Asp Thr Arg Tyr Thr Gln Lys Phe Lys 
        195                 200                 205             


Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr Met 
    210                 215                 220                 


Gln Leu Ser Ser Leu Ala Ser Glu Asp Ser Ala Val Tyr Tyr Cys Ala 
225                 230                 235                 240 


Arg Gly Lys Val Tyr Tyr Gly Ser Asn Pro Phe Ala Tyr Trp Gly Gln 
                245                 250                 255     


Gly Thr Leu Val Thr Val Ser Ala Thr Thr Thr Pro Ala Pro Arg Pro 
            260                 265                 270         


Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro 
        275                 280                 285             


Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu 
    290                 295                 300                 


Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys 
305                 310                 315                 320 


Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Arg Ser Lys 
                325                 330                 335     


Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg 
            340                 345                 350         


Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp 
        355                 360                 365             


Phe Ala Ala Tyr Arg Ser Arg Val Lys Phe Ser Arg Ser Ala Asp Ala 
    370                 375                 380                 


Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu 
385                 390                 395                 400 


Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp 
                405                 410                 415     


Pro Glu Met Gly Gly Lys Pro Gln Arg Arg Lys Asn Pro Gln Glu Gly 
            420                 425                 430         


Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu 
        435                 440                 445             


Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu 
    450                 455                 460                 


Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His 
465                 470                 475                 480 


Met Gln Ala Leu Pro Pro Arg 
                485         


<210>  183
<211>  1471
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  (CS1-mu34-28-2G CAR nucleotide sequence)

<400>  183
tggccttacc agtgaccgcc ttgctcctgc cgctggcctt gctgctccac gccgccaggc       60

cggacatcca gatgacccag agcagcagct acctgagcgt gagcctgggc ggcagggtga      120

ccatcacctg caaggccagc gaccacatca acaactggct ggcctggtac cagcagaagc      180

ccggcaacgc ccccaggctg ctgatcagcg gcgccaccag cctggagacc ggcgtgccca      240

gcaggttcag cggcagcggc agcggcaagg actacaccct gagcatcacc agcctgcaga      300

ccgaggacgt ggccacctac tactgccagc agtactggag caccccctgg accttcggcg      360

gcggcaccaa gctggagatc aagggagggg ggggatccgg gggaggaggc tccggcggag      420

gcggaagcca ggtgcagctg cagcagagcg gcgccgagct ggccaggccc ggcgccagcg      480

tgaagctgag ctgcaaggcc agcggctaca ccttcaccag ctactggatg cagtgggtga      540

agcagaggcc cggccagggc ctggagtgga tcggcgccat ctaccccggc gacggcgaca      600

ccaggtacac ccagaagttc aagggcaagg ccaccctgac cgccgacaag agcagcagca      660

ccgcctacat gcagctgagc agcctggcca gcgaggacag cgccgtgtac tactgcgcca      720

ggggcaaggt gtactacggc agcaacccct tcgcctactg gggccagggc accctggtga      780

ccgtgagcgc caccacgacg ccagcgccgc gaccaccaac accggcgccc accatcgcgt      840

cgcagcccct gtccctgcgc ccagaggcgt gccggccagc ggcggggggc gcagtgcaca      900

cgagggggct ggacttcgcc tgtgatatct acatctgggc gcccttggcc gggacttgtg      960

gggtccttct cctgtcactg gttatcaccc tttactgcag gagtaagagg agcaggctcc     1020

tgcacagtga ctacatgaac atgactcccc gccgccccgg gcccacccgc aagcattacc     1080

agccctatgc cccaccacgc gacttcgcag cctatcgctc cagagtgaag ttcagcagga     1140

gcgcagacgc ccccgcgtac cagcagggcc agaaccagct ctataacgag ctcaatctag     1200

gacgaagaga ggagtacgat gttttggaca agagacgtgg ccgggaccct gagatggggg     1260

gaaagccgca gagaaggaag aaccctcagg aaggcctgta caatgaactg cagaaagata     1320

agatggcgga ggcctacagt gagattggga tgaaaggcga gcgccggagg ggcaaggggc     1380

acgatggcct ttaccagggt ctcagtacag ccaccaagga cacctacgac gcccttcaca     1440

tgcaggccct gccccctcgc taagtttaaa c                                    1471


<210>  184
<211>  485
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  (CS1-mu90-28-2G CAR amino acid sequence)

<400>  184

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Asp Ile Val Met Thr Gln Ser Gln Lys Ser Met 
            20                  25                  30          


Ser Thr Ser Val Gly Asp Arg Val Ser Ile Thr Cys Lys Ala Ser Gln 
        35                  40                  45              


Asp Val Ile Thr Gly Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser 
    50                  55                  60                  


Pro Lys Leu Leu Ile Tyr Ser Ala Ser Tyr Arg Tyr Thr Gly Val Pro 
65                  70                  75                  80  


Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile 
                85                  90                  95      


Ser Asn Val Gln Ala Glu Asp Leu Ala Val Tyr Tyr Cys Gln Gln His 
            100                 105                 110         


Tyr Ser Thr Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln 
    130                 135                 140                 


Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Arg Pro Gly Ala Ser 
145                 150                 155                 160 


Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Thr Tyr Trp 
                165                 170                 175     


Met Asn Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile Gly 
            180                 185                 190         


Met Ile His Pro Ser Asp Ser Glu Thr Arg Leu Asn Lys Phe Lys Asp 
        195                 200                 205             


Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr Met Gln 
    210                 215                 220                 


Leu Ser Ser Pro Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys Ala Arg 
225                 230                 235                 240 


Ser Thr Met Ile Ala Thr Arg Ala Met Asp Tyr Trp Gly Gln Gly Thr 
                245                 250                 255     


Ser Val Thr Val Ser Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr 
            260                 265                 270         


Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala 
        275                 280                 285             


Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe 
    290                 295                 300                 


Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val 
305                 310                 315                 320 


Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Arg Ser Lys Arg Ser 
                325                 330                 335     


Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly 
            340                 345                 350         


Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala 
        355                 360                 365             


Ala Tyr Arg Ser Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala 
    370                 375                 380                 


Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg 
385                 390                 395                 400 


Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu 
                405                 410                 415     


Met Gly Gly Lys Pro Gln Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr 
            420                 425                 430         


Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly 
        435                 440                 445             


Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln 
    450                 455                 460                 


Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln 
465                 470                 475                 480 


Ala Leu Pro Pro Arg 
                485 


<210>  185
<211>  1466
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  (CS1-mu90-28-2G CAR nucleotide sequence)

<400>  185
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccggacatcg tgatgaccca gagccagaag agcatgagca ccagcgtggg cgacagggtg      120

agcatcacct gcaaggccag ccaggacgtg atcaccggcg tggcctggta ccagcagaag      180

cccggccaga gccccaagct gctgatctac agcgccagct acaggtacac cggcgtgccc      240

gacaggttca ccggcagcgg cagcggcacc gacttcacct tcaccatcag caacgtgcag      300

gccgaggacc tggccgtgta ctactgccag cagcactaca gcacccccct gaccttcggc      360

gccggcacca agctggagct gaagggaggg gggggatccg ggggaggagg ctccggcgga      420

ggcggaagcc aggtgcagct gcagcagccc ggcgccgagc tggtgaggcc cggcgccagc      480

gtgaagctga gctgcaaggc cagcggctac agcttcacca cctactggat gaactgggtg      540

aagcagaggc ccggccaggg cctggagtgg atcggcatga tccaccccag cgacagcgag      600

accaggctga acaagttcaa ggacaaggcc accctgaccg tggacaagag cagcagcacc      660

gcctacatgc agctgagcag ccccaccagc gaggacagcg ccgtgtacta ctgcgccagg      720

agcaccatga tcgccaccag ggccatggac tactggggcc agggcaccag cgtgaccgtg      780

agcagcacca cgacgccagc gccgcgacca ccaacaccgg cgcccaccat cgcgtcgcag      840

cccctgtccc tgcgcccaga ggcgtgccgg ccagcggcgg ggggcgcagt gcacacgagg      900

gggctggact tcgcctgtga tatctacatc tgggcgccct tggccgggac ttgtggggtc      960

cttctcctgt cactggttat caccctttac tgcaggagta agaggagcag gctcctgcac     1020

agtgactaca tgaacatgac tccccgccgc cccgggccca cccgcaagca ttaccagccc     1080

tatgccccac cacgcgactt cgcagcctat cgctccagag tgaagttcag caggagcgca     1140

gacgcccccg cgtaccagca gggccagaac cagctctata acgagctcaa tctaggacga     1200

agagaggagt acgatgtttt ggacaagaga cgtggccggg accctgagat ggggggaaag     1260

ccgcagagaa ggaagaaccc tcaggaaggc ctgtacaatg aactgcagaa agataagatg     1320

gcggaggcct acagtgagat tgggatgaaa ggcgagcgcc ggaggggcaa ggggcacgat     1380

ggcctttacc agggtctcag tacagccacc aaggacacct acgacgccct tcacatgcag     1440

gccctgcccc ctcgctaagt ttaaac                                          1466


<210>  186
<211>  772
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  (CD33b-28-4-1BBL CAR amino acid sequence)

<400>  186

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Met Ala Asp Tyr Lys Asp Ile Val Met Thr Gln 
            20                  25                  30          


Ser His Lys Phe Leu Leu Val Ser Val Gly Asp Arg Val Ser Ile Thr 
        35                  40                  45              


Cys Lys Ala Ser Gln Asp Val Ser Thr Ala Val Ala Trp Tyr Gln Gln 
    50                  55                  60                  


Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile Tyr Ser Ala Ser Tyr Arg 
65                  70                  75                  80  


Tyr Thr Gly Val Pro Asp Arg Phe Ile Gly Ser Gly Ser Gly Thr Asp 
                85                  90                  95      


Phe Thr Leu Thr Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Asp Tyr 
            100                 105                 110         


Phe Cys Gln Gln His Tyr Ser Thr Pro Leu Thr Phe Gly Ala Gly Thr 
        115                 120                 125             


Lys Leu Glu Ile Lys Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Ser Gly Gly Gly Ser Glu Val Gln Leu Lys Glu 
145                 150                 155                 160 


Ser Gly Pro Gly Leu Val Ala Pro Ser Gln Ser Leu Ser Ile Thr Cys 
                165                 170                 175     


Thr Val Ser Gly Phe Pro Leu Thr Ser Tyr Gly Val Ser Trp Val Arg 
            180                 185                 190         


Gln Pro Pro Gly Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Gly Asp 
        195                 200                 205             


Gly Ser Thr Asn Tyr His Ser Ala Leu Ile Ser Arg Leu Ser Ile Ser 
    210                 215                 220                 


Lys Asp Asn Ser Lys Ser Gln Val Phe Leu Lys Leu Asn Asn Leu Gln 
225                 230                 235                 240 


Thr Asp Asp Thr Ala Thr Tyr Tyr Cys Ala Arg Asp Thr Tyr Tyr Pro 
                245                 250                 255     


Tyr Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser 
            260                 265                 270         


Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile 
        275                 280                 285             


Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala 
    290                 295                 300                 


Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr 
305                 310                 315                 320 


Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu 
                325                 330                 335     


Val Ile Thr Leu Tyr Cys Arg Ser Lys Arg Ser Arg Leu Leu His Ser 
            340                 345                 350         


Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His 
        355                 360                 365             


Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Arg 
    370                 375                 380                 


Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln 
385                 390                 395                 400 


Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp 
                405                 410                 415     


Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro 
            420                 425                 430         


Gln Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys 
        435                 440                 445             


Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg 
    450                 455                 460                 


Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala 
465                 470                 475                 480 


Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
                485                 490                 495     


Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val 
            500                 505                 510         


Glu Glu Asn Pro Gly Pro Met Glu Tyr Ala Ser Asp Ala Ser Leu Asp 
        515                 520                 525             


Pro Glu Ala Pro Trp Pro Pro Ala Pro Arg Ala Arg Ala Cys Arg Val 
    530                 535                 540                 


Leu Pro Trp Ala Leu Val Ala Gly Leu Leu Leu Leu Leu Leu Leu Ala 
545                 550                 555                 560 


Ala Ala Cys Ala Val Phe Leu Ala Cys Pro Trp Ala Val Ser Gly Ala 
                565                 570                 575     


Arg Ala Ser Pro Gly Ser Ala Ala Ser Pro Arg Leu Arg Glu Gly Pro 
            580                 585                 590         


Glu Leu Ser Pro Asp Asp Pro Ala Gly Leu Leu Asp Leu Arg Gln Gly 
        595                 600                 605             


Met Phe Ala Gln Leu Val Ala Gln Asn Val Leu Leu Ile Asp Gly Pro 
    610                 615                 620                 


Leu Ser Trp Tyr Ser Asp Pro Gly Leu Ala Gly Val Ser Leu Thr Gly 
625                 630                 635                 640 


Gly Leu Ser Tyr Lys Glu Asp Thr Lys Glu Leu Val Val Ala Lys Ala 
                645                 650                 655     


Gly Val Tyr Tyr Val Phe Phe Gln Leu Glu Leu Arg Arg Val Val Ala 
            660                 665                 670         


Gly Glu Gly Ser Gly Ser Val Ser Leu Ala Leu His Leu Gln Pro Leu 
        675                 680                 685             


Arg Ser Ala Ala Gly Ala Ala Ala Leu Ala Leu Thr Val Asp Leu Pro 
    690                 695                 700                 


Pro Ala Ser Ser Glu Ala Arg Asn Ser Ala Phe Gly Phe Gln Gly Arg 
705                 710                 715                 720 


Leu Leu His Leu Ser Ala Gly Gln Arg Leu Gly Val His Leu His Thr 
                725                 730                 735     


Glu Ala Arg Ala Arg His Ala Trp Gln Leu Thr Gln Gly Ala Thr Val 
            740                 745                 750         


Leu Gly Leu Phe Arg Val Thr Pro Glu Ile Pro Ala Gly Leu Pro Ser 
        755                 760                 765             


Pro Arg Ser Glu 
    770         


<210>  187
<211>  2327
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  (CD33b-28-4-1BBL CAR nucleotide sequence)

<400>  187
atggccctgc ccgtgaccgc cctgctgctg cccctggccc tgctgctgca cgccgccagg       60

cccatggccg actacaagga catcgtgatg acccagagcc acaagttcct gctggtgagc      120

gtgggcgaca gggtgagcat cacctgcaag gccagccagg acgtgagcac cgccgtggcc      180

tggtaccagc agaagcccgg ccagagcccc aagctgctga tctacagcgc cagctacagg      240

tacaccggcg tgcccgacag gttcatcggc agcggcagcg gcaccgactt caccctgacc      300

atcagcagcg tgcaggccga ggacctggcc gactacttct gccagcagca ctacagcacc      360

cccctgacct tcggcgccgg caccaagctg gagatcaaga ggggcggcgg cggcagcggc      420

ggcggcggca gcggcggcgg cggcagcagc ggcggcggca gcgaggtgca gctgaaggag      480

agcggccccg gcctggtggc ccccagccag agcctgagca tcacctgcac cgtgagcggc      540

ttccccctga ccagctacgg cgtgagctgg gtgaggcagc cccccggcaa gggcctggag      600

tggctgggcg tgatctgggg cgacggcagc accaactacc acagcgccct gatcagcagg      660

ctgagcatca gcaaggacaa cagcaagagc caggtgttcc tgaagctgaa caacctgcag      720

accgacgaca ccgccaccta ctactgcgcc agggacacct actaccccta ctacgccatg      780

gactactggg gccagggcac cagcgtgacc gtgagcagca ccaccacccc cgcccccagg      840

ccccccaccc ccgcccccac catcgccagc cagcccctga gcctgaggcc cgaggcctgc      900

aggcccgccg ccggcggcgc cgtgcacacc aggggcctgg acttcgcctg cgacatctac      960

atctgggccc ccctggccgg cacctgcggc gtgctgctgc tgagcctggt gatcaccctg     1020

tactgcagga gtaagaggag caggctcctg cacagtgact acatgaacat gactccccgc     1080

cgccccgggc ccacccgcaa gcattaccag ccctatgccc caccacgcga cttcgcagcc     1140

tatcgctcca gggtgaagtt cagcaggagc gccgacgccc ccgcctacca gcagggccag     1200

aaccagctgt acaacgagct gaacctgggc aggagggagg agtacgacgt gctggacaag     1260

aggaggggca gggaccccga gatgggcggc aagccccaga ggaggaagaa cccccaggag     1320

ggcctgtaca acgagctgca gaaggacaag atggccgagg cctacagcga gatcggcatg     1380

aagggcgaga ggaggagggg caagggccac gacggcctgt accagggcct gagcaccgcc     1440

accaaggaca cctacgacgc cctgcacatg caggccctgc cccccagggg aagcggagcc     1500

accaacttca gcctgctgaa gcaggccggc gacgtggagg agaaccccgg ccccatggaa     1560

tacgcctctg acgcttcact ggaccccgaa gccccgtggc ctcccgcgcc ccgcgctcgc     1620

gcctgccgcg tactgccttg ggccctggtc gcggggctgc tgctgctgct gctgctcgct     1680

gccgcctgcg ccgtcttcct cgcctgcccc tgggccgtgt ccggggctcg cgcctcgccc     1740

ggctccgcgg ccagcccgag actccgcgag ggtcccgagc tttcgcccga cgatcccgcc     1800

ggcctcttgg acctgcggca gggcatgttt gcgcagctgg tggcccaaaa tgttctgctg     1860

atcgatgggc ccctgagctg gtacagtgac ccaggcctgg caggcgtgtc cctgacgggg     1920

ggcctgagct acaaagagga cacgaaggag ctggtggtgg ccaaggctgg agtctactat     1980

gtcttctttc aactagagct gcggcgcgtg gtggccggcg agggctcagg ctccgtttca     2040

cttgcgctgc acctgcagcc actgcgctct gctgctgggg ccgccgccct ggctttgacc     2100

gtggacctgc cacccgcctc ctccgaggct cggaactcgg ccttcggttt ccagggccgc     2160

ttgctgcacc tgagtgccgg ccagcgcctg ggcgtccatc ttcacactga ggccagggca     2220

cgccatgcct ggcagcttac ccagggcgcc acagtcttgg gactcttccg ggtgaccccc     2280

gaaatcccag ccggactccc ttcaccgagg tcggaataag tttaaac                   2327


<210>  188
<211>  792
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  (CD33b-BB-IL-15/IL-15sushi CAR amino acid sequence)

<400>  188

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Met Ala Asp Tyr Lys Asp Ile Val Met Thr Gln 
            20                  25                  30          


Ser His Lys Phe Leu Leu Val Ser Val Gly Asp Arg Val Ser Ile Thr 
        35                  40                  45              


Cys Lys Ala Ser Gln Asp Val Ser Thr Ala Val Ala Trp Tyr Gln Gln 
    50                  55                  60                  


Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile Tyr Ser Ala Ser Tyr Arg 
65                  70                  75                  80  


Tyr Thr Gly Val Pro Asp Arg Phe Ile Gly Ser Gly Ser Gly Thr Asp 
                85                  90                  95      


Phe Thr Leu Thr Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Asp Tyr 
            100                 105                 110         


Phe Cys Gln Gln His Tyr Ser Thr Pro Leu Thr Phe Gly Ala Gly Thr 
        115                 120                 125             


Lys Leu Glu Ile Lys Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Ser Gly Gly Gly Ser Glu Val Gln Leu Lys Glu 
145                 150                 155                 160 


Ser Gly Pro Gly Leu Val Ala Pro Ser Gln Ser Leu Ser Ile Thr Cys 
                165                 170                 175     


Thr Val Ser Gly Phe Pro Leu Thr Ser Tyr Gly Val Ser Trp Val Arg 
            180                 185                 190         


Gln Pro Pro Gly Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Gly Asp 
        195                 200                 205             


Gly Ser Thr Asn Tyr His Ser Ala Leu Ile Ser Arg Leu Ser Ile Ser 
    210                 215                 220                 


Lys Asp Asn Ser Lys Ser Gln Val Phe Leu Lys Leu Asn Asn Leu Gln 
225                 230                 235                 240 


Thr Asp Asp Thr Ala Thr Tyr Tyr Cys Ala Arg Asp Thr Tyr Tyr Pro 
                245                 250                 255     


Tyr Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser 
            260                 265                 270         


Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile 
        275                 280                 285             


Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala 
    290                 295                 300                 


Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr 
305                 310                 315                 320 


Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu 
                325                 330                 335     


Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile 
            340                 345                 350         


Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp 
        355                 360                 365             


Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
    370                 375                 380                 


Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly 
385                 390                 395                 400 


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
                405                 410                 415     


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
            420                 425                 430         


Pro Gln Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln 
        435                 440                 445             


Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu 
    450                 455                 460                 


Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr 
465                 470                 475                 480 


Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro 
                485                 490                 495     


Arg Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp 
            500                 505                 510         


Val Glu Glu Asn Pro Gly Pro Met Tyr Arg Met Gln Leu Leu Ser Cys 
        515                 520                 525             


Ile Ala Leu Ser Leu Ala Leu Val Thr Asn Ser Gly Ile His Val Phe 
    530                 535                 540                 


Ile Leu Gly Cys Phe Ser Ala Gly Leu Pro Lys Thr Glu Ala Asn Trp 
545                 550                 555                 560 


Val Asn Val Ile Ser Asp Leu Lys Lys Ile Glu Asp Leu Ile Gln Ser 
                565                 570                 575     


Met His Ile Asp Ala Thr Leu Tyr Thr Glu Ser Asp Val His Pro Ser 
            580                 585                 590         


Cys Lys Val Thr Ala Met Lys Cys Phe Leu Leu Glu Leu Gln Val Ile 
        595                 600                 605             


Ser Leu Glu Ser Gly Asp Ala Ser Ile His Asp Thr Val Glu Asn Leu 
    610                 615                 620                 


Ile Ile Leu Ala Asn Asn Ser Leu Ser Ser Asn Gly Asn Val Thr Glu 
625                 630                 635                 640 


Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu Lys Asn Ile Lys Glu 
                645                 650                 655     


Phe Leu Gln Ser Phe Val His Ile Val Gln Met Phe Ile Asn Thr Ser 
            660                 665                 670         


Ser Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        675                 680                 685             


Gly Gly Gly Ser Gly Gly Gly Ser Leu Gln Ala Pro Arg Arg Ala Arg 
    690                 695                 700                 


Gly Cys Arg Thr Leu Gly Leu Pro Ala Leu Leu Leu Leu Leu Leu Leu 
705                 710                 715                 720 


Arg Pro Pro Ala Thr Arg Gly Ile Thr Cys Pro Pro Pro Met Ser Val 
                725                 730                 735     


Glu His Ala Asp Ile Trp Val Lys Ser Tyr Ser Leu Tyr Ser Arg Glu 
            740                 745                 750         


Arg Tyr Ile Cys Asn Ser Gly Phe Lys Arg Lys Ala Gly Thr Ser Ser 
        755                 760                 765             


Leu Thr Glu Cys Val Leu Asn Lys Ala Thr Asn Val Ala His Trp Thr 
    770                 775                 780                 


Thr Pro Ser Leu Lys Cys Ile Arg 
785                 790         


<210>  189
<211>  2387
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  (CD33b-BB-IL-15/IL-15sushi CAR nucleotide sequence)

<400>  189
atggccctgc ccgtgaccgc cctgctgctg cccctggccc tgctgctgca cgccgccagg       60

cccatggccg actacaagga catcgtgatg acccagagcc acaagttcct gctggtgagc      120

gtgggcgaca gggtgagcat cacctgcaag gccagccagg acgtgagcac cgccgtggcc      180

tggtaccagc agaagcccgg ccagagcccc aagctgctga tctacagcgc cagctacagg      240

tacaccggcg tgcccgacag gttcatcggc agcggcagcg gcaccgactt caccctgacc      300

atcagcagcg tgcaggccga ggacctggcc gactacttct gccagcagca ctacagcacc      360

cccctgacct tcggcgccgg caccaagctg gagatcaaga ggggcggcgg cggcagcggc      420

ggcggcggca gcggcggcgg cggcagcagc ggcggcggca gcgaggtgca gctgaaggag      480

agcggccccg gcctggtggc ccccagccag agcctgagca tcacctgcac cgtgagcggc      540

ttccccctga ccagctacgg cgtgagctgg gtgaggcagc cccccggcaa gggcctggag      600

tggctgggcg tgatctgggg cgacggcagc accaactacc acagcgccct gatcagcagg      660

ctgagcatca gcaaggacaa cagcaagagc caggtgttcc tgaagctgaa caacctgcag      720

accgacgaca ccgccaccta ctactgcgcc agggacacct actaccccta ctacgccatg      780

gactactggg gccagggcac cagcgtgacc gtgagcagca ccaccacccc cgcccccagg      840

ccccccaccc ccgcccccac catcgccagc cagcccctga gcctgaggcc cgaggcctgc      900

aggcccgccg ccggcggcgc cgtgcacacc aggggcctgg acttcgcctg cgacatctac      960

atctgggccc ccctggccgg cacctgcggc gtgctgctgc tgagcctggt gatcaccctg     1020

tactgcaaac ggggcagaaa gaaactcctg tatatattca aacaaccatt tatgagacca     1080

gtacaaacta ctcaagagga agatggctgt agctgccgat ttccagaaga agaagaagga     1140

ggatgtgaac tgagggtgaa gttcagcagg agcgccgacg cccccgccta ccagcagggc     1200

cagaaccagc tgtacaacga gctgaacctg ggcaggaggg aggagtacga cgtgctggac     1260

aagaggaggg gcagggaccc cgagatgggc ggcaagcccc agaggaggaa gaacccccag     1320

gagggcctgt acaacgagct gcagaaggac aagatggccg aggcctacag cgagatcggc     1380

atgaagggcg agaggaggag gggcaagggc cacgacggcc tgtaccaggg cctgagcacc     1440

gccaccaagg acacctacga cgccctgcac atgcaggccc tgccccccag gggaagcgga     1500

gccaccaact tcagcctgct gaagcaggcc ggcgacgtgg aggagaaccc cggccccatg     1560

tacagaatgc agctgctgag ctgcatcgcc ctgagcctgg ccctggtgac caacagcggc     1620

atccacgtgt tcatcctggg ctgcttcagc gccggcctgc ccaagaccga ggccaactgg     1680

gtgaacgtga tcagcgacct gaagaagatc gaggacctga tccagagcat gcacatcgac     1740

gccaccctgt acaccgagag cgacgtgcac cccagctgca aggtgaccgc catgaagtgc     1800

ttcctgctgg agctgcaggt gatcagcctg gagagcggcg acgccagcat ccacgacacc     1860

gtggagaacc tgatcatcct ggccaacaac agcctgagca gcaacggcaa cgtgaccgag     1920

agcggctgca aggagtgcga ggagctggag gagaagaaca tcaaggagtt cctgcagagc     1980

ttcgtgcaca tcgtgcagat gttcatcaac accagctccg gcggcggctc cggcggcggc     2040

ggctccggcg gcggcggctc cggcggcggc ggctccggcg gcggctccct gcaggccccc     2100

agaagagcca gaggctgcag aaccctgggc ctgcccgccc tgctgctgct gctgctgctg     2160

agaccccccg ccaccagagg catcacctgc ccccccccca tgagcgtgga gcacgccgac     2220

atctgggtga agagctacag cctgtacagc agagagagat acatctgcaa cagcggcttc     2280

aagagaaagg ccggcaccag cagcctgacc gagtgcgtgc tgaacaaggc caccaacgtg     2340

gcccactgga ccacccccag cctgaagtgc atcagataag tttaaac                   2387


<210>  190
<211>  829
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  (CD33b-28-IL-15/IL-15 anchor CAR amino acid sequence)

<400>  190

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Met Ala Asp Tyr Lys Asp Ile Val Met Thr Gln 
            20                  25                  30          


Ser His Lys Phe Leu Leu Val Ser Val Gly Asp Arg Val Ser Ile Thr 
        35                  40                  45              


Cys Lys Ala Ser Gln Asp Val Ser Thr Ala Val Ala Trp Tyr Gln Gln 
    50                  55                  60                  


Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile Tyr Ser Ala Ser Tyr Arg 
65                  70                  75                  80  


Tyr Thr Gly Val Pro Asp Arg Phe Ile Gly Ser Gly Ser Gly Thr Asp 
                85                  90                  95      


Phe Thr Leu Thr Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Asp Tyr 
            100                 105                 110         


Phe Cys Gln Gln His Tyr Ser Thr Pro Leu Thr Phe Gly Ala Gly Thr 
        115                 120                 125             


Lys Leu Glu Ile Lys Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Ser Gly Gly Gly Ser Glu Val Gln Leu Lys Glu 
145                 150                 155                 160 


Ser Gly Pro Gly Leu Val Ala Pro Ser Gln Ser Leu Ser Ile Thr Cys 
                165                 170                 175     


Thr Val Ser Gly Phe Pro Leu Thr Ser Tyr Gly Val Ser Trp Val Arg 
            180                 185                 190         


Gln Pro Pro Gly Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Gly Asp 
        195                 200                 205             


Gly Ser Thr Asn Tyr His Ser Ala Leu Ile Ser Arg Leu Ser Ile Ser 
    210                 215                 220                 


Lys Asp Asn Ser Lys Ser Gln Val Phe Leu Lys Leu Asn Asn Leu Gln 
225                 230                 235                 240 


Thr Asp Asp Thr Ala Thr Tyr Tyr Cys Ala Arg Asp Thr Tyr Tyr Pro 
                245                 250                 255     


Tyr Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser 
            260                 265                 270         


Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile 
        275                 280                 285             


Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala 
    290                 295                 300                 


Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr 
305                 310                 315                 320 


Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu 
                325                 330                 335     


Val Ile Thr Leu Tyr Cys Arg Ser Lys Arg Ser Arg Leu Leu His Ser 
            340                 345                 350         


Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His 
        355                 360                 365             


Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Arg 
    370                 375                 380                 


Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln 
385                 390                 395                 400 


Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp 
                405                 410                 415     


Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro 
            420                 425                 430         


Gln Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys 
        435                 440                 445             


Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg 
    450                 455                 460                 


Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala 
465                 470                 475                 480 


Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
                485                 490                 495     


Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val 
            500                 505                 510         


Glu Glu Asn Pro Gly Pro Met Tyr Arg Met Gln Leu Leu Ser Cys Ile 
        515                 520                 525             


Ala Leu Ser Leu Ala Leu Val Thr Asn Ser Gly Ile His Val Phe Ile 
    530                 535                 540                 


Leu Gly Cys Phe Ser Ala Gly Leu Pro Lys Thr Glu Ala Asn Trp Val 
545                 550                 555                 560 


Asn Val Ile Ser Asp Leu Lys Lys Ile Glu Asp Leu Ile Gln Ser Met 
                565                 570                 575     


His Ile Asp Ala Thr Leu Tyr Thr Glu Ser Asp Val His Pro Ser Cys 
            580                 585                 590         


Lys Val Thr Ala Met Lys Cys Phe Leu Leu Glu Leu Gln Val Ile Ser 
        595                 600                 605             


Leu Glu Ser Gly Asp Ala Ser Ile His Asp Thr Val Glu Asn Leu Ile 
    610                 615                 620                 


Ile Leu Ala Asn Asn Ser Leu Ser Ser Asn Gly Asn Val Thr Glu Ser 
625                 630                 635                 640 


Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu Lys Asn Ile Lys Glu Phe 
                645                 650                 655     


Leu Gln Ser Phe Val His Ile Val Gln Met Phe Ile Asn Thr Ser Ser 
            660                 665                 670         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
        675                 680                 685             


Gly Gly Ser Gly Gly Gly Ser Leu Gln Ile Thr Cys Pro Pro Pro Met 
    690                 695                 700                 


Ser Val Glu His Ala Asp Ile Trp Val Lys Ser Tyr Ser Leu Tyr Ser 
705                 710                 715                 720 


Arg Glu Arg Tyr Ile Cys Asn Ser Gly Phe Lys Arg Lys Ala Gly Thr 
                725                 730                 735     


Ser Ser Leu Thr Glu Cys Val Leu Asn Lys Ala Thr Asn Val Ala His 
            740                 745                 750         


Trp Thr Thr Pro Ser Leu Lys Cys Ile Arg Thr Thr Thr Pro Ala Pro 
        755                 760                 765             


Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu 
    770                 775                 780                 


Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg 
785                 790                 795                 800 


Gly Leu Asp Phe Ala Cys Asp Val Ala Ile Ser Thr Ser Thr Val Leu 
                805                 810                 815     


Leu Cys Gly Leu Ser Ala Val Ser Leu Leu Ala Cys Tyr 
            820                 825                 


<210>  191
<211>  2498
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  (CD33b-28-IL-15/IL-15 anchor CAR nucleotide sequence)

<400>  191
atggccctgc ccgtgaccgc cctgctgctg cccctggccc tgctgctgca cgccgccagg       60

cccatggccg actacaagga catcgtgatg acccagagcc acaagttcct gctggtgagc      120

gtgggcgaca gggtgagcat cacctgcaag gccagccagg acgtgagcac cgccgtggcc      180

tggtaccagc agaagcccgg ccagagcccc aagctgctga tctacagcgc cagctacagg      240

tacaccggcg tgcccgacag gttcatcggc agcggcagcg gcaccgactt caccctgacc      300

atcagcagcg tgcaggccga ggacctggcc gactacttct gccagcagca ctacagcacc      360

cccctgacct tcggcgccgg caccaagctg gagatcaaga ggggcggcgg cggcagcggc      420

ggcggcggca gcggcggcgg cggcagcagc ggcggcggca gcgaggtgca gctgaaggag      480

agcggccccg gcctggtggc ccccagccag agcctgagca tcacctgcac cgtgagcggc      540

ttccccctga ccagctacgg cgtgagctgg gtgaggcagc cccccggcaa gggcctggag      600

tggctgggcg tgatctgggg cgacggcagc accaactacc acagcgccct gatcagcagg      660

ctgagcatca gcaaggacaa cagcaagagc caggtgttcc tgaagctgaa caacctgcag      720

accgacgaca ccgccaccta ctactgcgcc agggacacct actaccccta ctacgccatg      780

gactactggg gccagggcac cagcgtgacc gtgagcagca ccaccacccc cgcccccagg      840

ccccccaccc ccgcccccac catcgccagc cagcccctga gcctgaggcc cgaggcctgc      900

aggcccgccg ccggcggcgc cgtgcacacc aggggcctgg acttcgcctg cgacatctac      960

atctgggccc ccctggccgg cacctgcggc gtgctgctgc tgagcctggt gatcaccctg     1020

tactgcagga gtaagaggag caggctcctg cacagtgact acatgaacat gactccccgc     1080

cgccccgggc ccacccgcaa gcattaccag ccctatgccc caccacgcga cttcgcagcc     1140

tatcgctcca gggtgaagtt cagcaggagc gccgacgccc ccgcctacca gcagggccag     1200

aaccagctgt acaacgagct gaacctgggc aggagggagg agtacgacgt gctggacaag     1260

aggaggggca gggaccccga gatgggcggc aagccccaga ggaggaagaa cccccaggag     1320

ggcctgtaca acgagctgca gaaggacaag atggccgagg cctacagcga gatcggcatg     1380

aagggcgaga ggaggagggg caagggccac gacggcctgt accagggcct gagcaccgcc     1440

accaaggaca cctacgacgc cctgcacatg caggccctgc cccccagggg aagcggagcc     1500

accaacttca gcctgctgaa gcaggccggc gacgtggagg agaaccccgg ccccatgtac     1560

agaatgcagc tgctgagctg catcgccctg agcctggccc tggtgaccaa cagcggcatc     1620

cacgtgttca tcctgggctg cttcagcgcc ggcctgccca agaccgaggc caactgggtg     1680

aacgtgatca gcgacctgaa gaagatcgag gacctgatcc agagcatgca catcgacgcc     1740

accctgtaca ccgagagcga cgtgcacccc agctgcaagg tgaccgccat gaagtgcttc     1800

ctgctggagc tgcaggtgat cagcctggag agcggcgacg ccagcatcca cgacaccgtg     1860

gagaacctga tcatcctggc caacaacagc ctgagcagca acggcaacgt gaccgagagc     1920

ggctgcaagg agtgcgagga gctggaggag aagaacatca aggagttcct gcagagcttc     1980

gtgcacatcg tgcagatgtt catcaacacc agctccggcg gcggctccgg cggcggcggc     2040

tccggcggcg gcggctccgg cggcggcggc tccggcggcg gctccctgca gatcacctgc     2100

ccccccccca tgagcgtgga gcacgccgac atctgggtga agagctacag cctgtacagc     2160

agagagagat acatctgcaa cagcggcttc aagagaaagg ccggcaccag cagcctgacc     2220

gagtgcgtgc tgaacaaggc caccaacgtg gcccactgga ccacccccag cctgaagtgc     2280

atcagaacca ccacccccgc ccccaggccc cccacccccg cccccaccat cgccagccag     2340

cccctgagcc tgaggcccga ggcctgcagg cccgccgccg gcggcgccgt gcacaccagg     2400

ggcctggact tcgcctgcga cgtggctatc tccacgtcca ctgtcctgct gtgtgggctg     2460

agcgctgtgt ctctcctggc atgctactaa gtttaaac                             2498


<210>  192
<211>  827
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  (CD19b-BB-IL-15/IL-15sushi anchor CAR amino acid sequence)

<400>  192

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu 
            20                  25                  30          


Ile Lys Pro Gly Ala Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr 
        35                  40                  45              


Thr Phe Thr Ser Tyr Val Met His Trp Val Lys Gln Lys Pro Gly Gln 
    50                  55                  60                  


Gly Leu Glu Trp Ile Gly Tyr Ile Asn Pro Tyr Asn Asp Gly Thr Lys 
65                  70                  75                  80  


Tyr Asn Glu Lys Phe Lys Gly Lys Ala Thr Leu Thr Ser Asp Lys Ser 
                85                  90                  95      


Ser Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Thr Ser Glu Asp Ser 
            100                 105                 110         


Ala Val Tyr Tyr Cys Ala Arg Gly Thr Tyr Tyr Tyr Gly Ser Arg Val 
        115                 120                 125             


Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val 
145                 150                 155                 160 


Met Thr Gln Ala Ala Pro Ser Ile Pro Val Thr Pro Gly Glu Ser Val 
                165                 170                 175     


Ser Ile Ser Cys Arg Ser Ser Lys Ser Leu Leu Asn Ser Asn Gly Asn 
            180                 185                 190         


Thr Tyr Leu Tyr Trp Phe Leu Gln Arg Pro Gly Gln Ser Pro Gln Leu 
        195                 200                 205             


Leu Ile Tyr Arg Met Ser Asn Leu Ala Ser Gly Val Pro Asp Arg Phe 
    210                 215                 220                 


Ser Gly Ser Gly Ser Gly Thr Ala Phe Thr Leu Arg Ile Ser Arg Val 
225                 230                 235                 240 


Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln His Leu Glu Tyr 
                245                 250                 255     


Pro Phe Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Arg Thr Thr 
            260                 265                 270         


Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln 
        275                 280                 285             


Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala 
    290                 295                 300                 


Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala 
305                 310                 315                 320 


Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr 
                325                 330                 335     


Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln 
            340                 345                 350         


Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser 
        355                 360                 365             


Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys 
    370                 375                 380                 


Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln 
385                 390                 395                 400 


Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu 
                405                 410                 415     


Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Gln Arg 
            420                 425                 430         


Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys 
        435                 440                 445             


Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg 
    450                 455                 460                 


Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys 
465                 470                 475                 480 


Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg Gly Ser 
                485                 490                 495     


Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu 
            500                 505                 510         


Asn Pro Gly Pro Met Tyr Arg Met Gln Leu Leu Ser Cys Ile Ala Leu 
        515                 520                 525             


Ser Leu Ala Leu Val Thr Asn Ser Gly Ile His Val Phe Ile Leu Gly 
    530                 535                 540                 


Cys Phe Ser Ala Gly Leu Pro Lys Thr Glu Ala Asn Trp Val Asn Val 
545                 550                 555                 560 


Ile Ser Asp Leu Lys Lys Ile Glu Asp Leu Ile Gln Ser Met His Ile 
                565                 570                 575     


Asp Ala Thr Leu Tyr Thr Glu Ser Asp Val His Pro Ser Cys Lys Val 
            580                 585                 590         


Thr Ala Met Lys Cys Phe Leu Leu Glu Leu Gln Val Ile Ser Leu Glu 
        595                 600                 605             


Ser Gly Asp Ala Ser Ile His Asp Thr Val Glu Asn Leu Ile Ile Leu 
    610                 615                 620                 


Ala Asn Asn Ser Leu Ser Ser Asn Gly Asn Val Thr Glu Ser Gly Cys 
625                 630                 635                 640 


Lys Glu Cys Glu Glu Leu Glu Glu Lys Asn Ile Lys Glu Phe Leu Gln 
                645                 650                 655     


Ser Phe Val His Ile Val Gln Met Phe Ile Asn Thr Ser Ser Gly Gly 
            660                 665                 670         


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        675                 680                 685             


Ser Gly Gly Gly Ser Leu Gln Ile Thr Cys Pro Pro Pro Met Ser Val 
    690                 695                 700                 


Glu His Ala Asp Ile Trp Val Lys Ser Tyr Ser Leu Tyr Ser Arg Glu 
705                 710                 715                 720 


Arg Tyr Ile Cys Asn Ser Gly Phe Lys Arg Lys Ala Gly Thr Ser Ser 
                725                 730                 735     


Leu Thr Glu Cys Val Leu Asn Lys Ala Thr Asn Val Ala His Trp Thr 
            740                 745                 750         


Thr Pro Ser Leu Lys Cys Ile Arg Thr Thr Thr Pro Ala Pro Arg Pro 
        755                 760                 765             


Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro 
    770                 775                 780                 


Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu 
785                 790                 795                 800 


Asp Phe Ala Cys Asp Val Ala Ile Ser Thr Ser Thr Val Leu Leu Cys 
                805                 810                 815     


Gly Leu Ser Ala Val Ser Leu Leu Ala Cys Tyr 
            820                 825         


<210>  193
<211>  2492
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  (CD19b-BB-IL-15/IL-15sushi anchor CAR nucleotide sequence)

<400>  193
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccggaggtcc agctgcagca gtctggacct gagctgataa agcctggggc ttcagtgaag      120

atgtcctgca aggcttctgg atacacattc actagctatg ttatgcactg ggtgaagcag      180

aagcctgggc agggccttga gtggattgga tatattaatc cttacaatga tggtactaag      240

tacaatgaga agttcaaagg caaggccaca ctgacttcag acaaatcctc cagcacagcc      300

tacatggagc tcagcagcct gacctctgag gactctgcgg tctattactg tgcaagaggg      360

acttattact acggtagtag ggtatttgac tactggggcc aaggcaccac tctcacagtc      420

tcctcaggtg gagggggctc aggcggaggt ggctctgggg gtggaggctc ggacattgtg      480

atgactcagg ctgcaccctc tatacctgtc actcctggag agtcagtatc catctcctgc      540

aggtctagta agagtctcct gaatagtaat ggcaacactt acttgtattg gttcctgcag      600

aggccaggcc agtctcctca gctcctgata tatcggatgt ccaaccttgc ctcaggagtc      660

ccagacaggt tcagtggcag tgggtcagga actgctttca cactgagaat cagtagagtg      720

gaggctgagg atgtgggtgt ttattactgt atgcaacatc tagaatatcc gttcacgttc      780

ggtgctggga ccaagctgga gctgaaacgg accacgacgc cagcgccgcg accaccaaca      840

ccggcgccca ccatcgcgtc gcagcccctg tccctgcgcc cagaggcgtg ccggccagcg      900

gcggggggcg cagtgcacac gagggggctg gacttcgcct gtgatatcta catctgggcg      960

cccttggccg ggacttgtgg ggtccttctc ctgtcactgg ttatcaccct ttactgcaaa     1020

cggggcagaa agaaactcct gtatatattc aaacaaccat ttatgagacc agtacaaact     1080

actcaagagg aagatggctg tagctgccga tttccagaag aagaagaagg aggatgtgaa     1140

ctgagagtga agttcagcag gagcgcagac gcccccgcgt accagcaggg ccagaaccag     1200

ctctataacg agctcaatct aggacgaaga gaggagtacg atgttttgga caagagacgt     1260

ggccgggacc ctgagatggg gggaaagccg cagagaagga agaaccctca ggaaggcctg     1320

tacaatgaac tgcagaaaga taagatggcg gaggcctaca gtgagattgg gatgaaaggc     1380

gagcgccgga ggggcaaggg gcacgatggc ctttaccagg gtctcagtac agccaccaag     1440

gacacctacg acgcccttca catgcaggcc ctgccccctc gcggaagcgg agccaccaac     1500

ttcagcctgc tgaagcaggc cggcgacgtg gaggagaacc ccggccccat gtacagaatg     1560

cagctgctga gctgcatcgc cctgagcctg gccctggtga ccaacagcgg catccacgtg     1620

ttcatcctgg gctgcttcag cgccggcctg cccaagaccg aggccaactg ggtgaacgtg     1680

atcagcgacc tgaagaagat cgaggacctg atccagagca tgcacatcga cgccaccctg     1740

tacaccgaga gcgacgtgca ccccagctgc aaggtgaccg ccatgaagtg cttcctgctg     1800

gagctgcagg tgatcagcct ggagagcggc gacgccagca tccacgacac cgtggagaac     1860

ctgatcatcc tggccaacaa cagcctgagc agcaacggca acgtgaccga gagcggctgc     1920

aaggagtgcg aggagctgga ggagaagaac atcaaggagt tcctgcagag cttcgtgcac     1980

atcgtgcaga tgttcatcaa caccagctcc ggcggcggct ccggcggcgg cggctccggc     2040

ggcggcggct ccggcggcgg cggctccggc ggcggctccc tgcagatcac ctgccccccc     2100

cccatgagcg tggagcacgc cgacatctgg gtgaagagct acagcctgta cagcagagag     2160

agatacatct gcaacagcgg cttcaagaga aaggccggca ccagcagcct gaccgagtgc     2220

gtgctgaaca aggccaccaa cgtggcccac tggaccaccc ccagcctgaa gtgcatcaga     2280

accaccaccc ccgcccccag gccccccacc cccgccccca ccatcgccag ccagcccctg     2340

agcctgaggc ccgaggcctg caggcccgcc gccggcggcg ccgtgcacac caggggcctg     2400

gacttcgcct gcgacgtggc tatctccacg tccactgtcc tgctgtgtgg gctgagcgct     2460

gtgtctctcc tggcatgcta ctaagtttaa ac                                   2492


<210>  194
<211>  201
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  (CLL-1, C-type lectin domain family 12 member A, C-type 
       lectin-like molecule 1, extracellular domain)

<400>  194

His Val Thr Leu Lys Ile Glu Met Lys Lys Met Asn Lys Leu Gln Asn 
1               5                   10                  15      


Ile Ser Glu Glu Leu Gln Arg Asn Ile Ser Leu Gln Leu Met Ser Asn 
            20                  25                  30          


Met Asn Ile Ser Asn Lys Ile Arg Asn Leu Ser Thr Thr Leu Gln Thr 
        35                  40                  45              


Ile Ala Thr Lys Leu Cys Arg Glu Leu Tyr Ser Lys Glu Gln Glu His 
    50                  55                  60                  


Lys Cys Lys Pro Cys Pro Arg Arg Trp Ile Trp His Lys Asp Ser Cys 
65                  70                  75                  80  


Tyr Phe Leu Ser Asp Asp Val Gln Thr Trp Gln Glu Ser Lys Met Ala 
                85                  90                  95      


Cys Ala Ala Gln Asn Ala Ser Leu Leu Lys Ile Asn Asn Lys Asn Ala 
            100                 105                 110         


Leu Glu Phe Ile Lys Ser Gln Ser Arg Ser Tyr Asp Tyr Trp Leu Gly 
        115                 120                 125             


Leu Ser Pro Glu Glu Asp Ser Thr Arg Gly Met Arg Val Asp Asn Ile 
    130                 135                 140                 


Ile Asn Ser Ser Ala Trp Val Ile Arg Asn Ala Pro Asp Leu Asn Asn 
145                 150                 155                 160 


Met Tyr Cys Gly Tyr Ile Asn Arg Leu Tyr Val Gln Tyr Tyr His Cys 
                165                 170                 175     


Thr Tyr Lys Lys Arg Met Ile Cys Glu Lys Met Ala Asn Pro Val Gln 
            180                 185                 190         


Leu Gly Ser Thr Tyr Phe Arg Glu Ala 
        195                 200     


<210>  195
<211>  994
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  (BCMA-A7D-CS1-hu63-2G, CD269-A7D-CS1-hu63-2G CD269-A7D-28-2G CAR 
       amino acid sequence)

<400>  195

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Asp Val Val Met Thr Gln Ser His Arg Phe Met 
            20                  25                  30          


Ser Thr Ser Val Gly Asp Arg Val Ser Ile Thr Cys Arg Ala Ser Gln 
        35                  40                  45              


Asp Val Asn Thr Ala Val Ser Trp Tyr Gln Gln Lys Pro Gly Gln Ser 
    50                  55                  60                  


Pro Lys Leu Leu Ile Phe Ser Ala Ser Tyr Arg Tyr Thr Gly Val Pro 
65                  70                  75                  80  


Asp Arg Phe Thr Gly Ser Gly Ser Gly Ala Asp Phe Thr Leu Thr Ile 
                85                  90                  95      


Ser Ser Val Gln Ala Glu Asp Leu Ala Val Tyr Tyr Cys Gln Gln His 
            100                 105                 110         


Tyr Ser Thr Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Asp Ile Lys 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln 
    130                 135                 140                 


Ile Gln Leu Val Gln Ser Gly Pro Asp Leu Lys Lys Pro Gly Glu Thr 
145                 150                 155                 160 


Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Phe Gly 
                165                 170                 175     


Met Asn Trp Val Lys Gln Ala Pro Gly Lys Gly Phe Lys Trp Met Ala 
            180                 185                 190         


Trp Ile Asn Thr Tyr Thr Gly Glu Ser Tyr Phe Ala Asp Asp Phe Lys 
        195                 200                 205             


Gly Arg Phe Ala Phe Ser Val Glu Thr Ser Ala Thr Thr Ala Tyr Leu 
    210                 215                 220                 


Gln Ile Asn Asn Leu Lys Thr Glu Asp Thr Ala Thr Tyr Phe Cys Ala 
225                 230                 235                 240 


Arg Gly Glu Ile Tyr Tyr Gly Tyr Asp Gly Gly Phe Ala Tyr Trp Gly 
                245                 250                 255     


Gln Gly Thr Leu Val Thr Val Ser Ala Thr Thr Thr Pro Ala Pro Arg 
            260                 265                 270         


Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg 
        275                 280                 285             


Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly 
    290                 295                 300                 


Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr 
305                 310                 315                 320 


Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Arg Ser 
                325                 330                 335     


Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg 
            340                 345                 350         


Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg 
        355                 360                 365             


Asp Phe Ala Ala Tyr Arg Ser Arg Val Lys Phe Ser Arg Ser Ala Asp 
    370                 375                 380                 


Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn 
385                 390                 395                 400 


Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg 
                405                 410                 415     


Asp Pro Glu Met Gly Gly Lys Pro Gln Arg Arg Lys Asn Pro Gln Glu 
            420                 425                 430         


Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser 
        435                 440                 445             


Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly 
    450                 455                 460                 


Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu 
465                 470                 475                 480 


His Met Gln Ala Leu Pro Pro Arg Gly Ser Gly Ala Thr Asn Phe Ser 
                485                 490                 495     


Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met Ala 
            500                 505                 510         


Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu His Ala 
        515                 520                 525             


Ala Arg Pro Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala 
    530                 535                 540                 


Ser Val Gly Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Val 
545                 550                 555                 560 


Gly Ile Ala Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Val Pro Lys 
                565                 570                 575     


Leu Leu Ile Tyr Trp Ala Ser Thr Arg His Thr Gly Val Pro Asp Arg 
            580                 585                 590         


Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser 
        595                 600                 605             


Leu Gln Pro Glu Asp Val Ala Thr Tyr Tyr Cys Gln Gln Tyr Ser Ser 
    610                 615                 620                 


Tyr Pro Tyr Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Gly Gly 
625                 630                 635                 640 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln 
                645                 650                 655     


Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg 
            660                 665                 670         


Leu Ser Cys Ala Ala Ser Gly Phe Phe Ser Arg Tyr Trp Met Ser Trp 
        675                 680                 685             


Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Gly Glu Ile Asn 
    690                 695                 700                 


Pro Asp Ser Ser Thr Ile Asn Tyr Ala Pro Ser Leu Lys Asp Lys Phe 
705                 710                 715                 720 


Ile Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr Leu Gln Met Asn 
                725                 730                 735     


Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Pro Asp 
            740                 745                 750         


Gly Asn Tyr Trp Tyr Phe Asp Val Trp Gly Gln Gly Thr Leu Val Thr 
        755                 760                 765             


Val Ser Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro 
    770                 775                 780                 


Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro 
785                 790                 795                 800 


Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp 
                805                 810                 815     


Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu 
            820                 825                 830         


Ser Leu Val Ile Thr Leu Tyr Cys Arg Ser Lys Arg Ser Arg Leu Leu 
        835                 840                 845             


His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg 
    850                 855                 860                 


Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg 
865                 870                 875                 880 


Ser Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln 
                885                 890                 895     


Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu 
            900                 905                 910         


Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly 
        915                 920                 925             


Lys Pro Gln Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu 
    930                 935                 940                 


Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly 
945                 950                 955                 960 


Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser 
                965                 970                 975     


Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro 
            980                 985                 990         


Pro Arg 
        


<210>  196
<211>  2993
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  (BCMA-A7D-CS1-hu63-2G, CD269-A7D-CS1-hu63-2G CD269-A7D-28-2G CAR 
       nucleotide sequence)

<400>  196
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccggacgtgg tgatgaccca gagccacagg ttcatgagca ccagcgtggg cgacagggtg      120

agcatcacct gcagggccag ccaggacgtg aacaccgccg tgagctggta ccagcagaag      180

cccggccaga gccccaagct gctgatcttc agcgccagct acaggtacac cggcgtgccc      240

gacaggttca ccggcagcgg cagcggcgcc gacttcaccc tgaccatcag cagcgtgcag      300

gccgaggacc tggccgtgta ctactgccag cagcactaca gcaccccctg gaccttcggc      360

ggcggcacca agctggacat caagggaggg gggggatccg ggggaggagg ctccggcgga      420

ggcggaagcc agatccagct ggtgcagagc ggccccgacc tgaagaagcc cggcgagacc      480

gtgaagctga gctgcaaggc cagcggctac accttcacca acttcggcat gaactgggtg      540

aagcaggccc ccggcaaggg cttcaagtgg atggcctgga tcaacaccta caccggcgag      600

agctacttcg ccgacgactt caagggcagg ttcgccttca gcgtggagac cagcgccacc      660

accgcctacc tgcagatcaa caacctgaag accgaggaca ccgccaccta cttctgcgcc      720

aggggcgaga tctactacgg ctacgacggc ggcttcgcct actggggcca gggcaccctg      780

gtgaccgtga gcgccaccac gacgccagcg ccgcgaccac caacaccggc gcccaccatc      840

gcgtcgcagc ccctgtccct gcgcccagag gcgtgccggc cagcggcggg gggcgcagtg      900

cacacgaggg ggctggactt cgcctgtgat atctacatct gggcgccctt ggccgggact      960

tgtggggtcc ttctcctgtc actggttatc accctttact gcaggagtaa gaggagcagg     1020

ctcctgcaca gtgactacat gaacatgact ccccgccgcc ccgggcccac ccgcaagcat     1080

taccagccct atgccccacc acgcgacttc gcagcctatc gctccagagt gaagttcagc     1140

aggagcgcag acgcccccgc gtaccagcag ggccagaacc agctctataa cgagctcaat     1200

ctaggacgaa gagaggagta cgatgttttg gacaagagac gtggccggga ccctgagatg     1260

gggggaaagc cgcagagaag gaagaaccct caggaaggcc tgtacaatga actgcagaaa     1320

gataagatgg cggaggccta cagtgagatt gggatgaaag gcgagcgccg gaggggcaag     1380

gggcacgatg gcctttacca gggtctcagt acagccacca aggacaccta cgacgccctt     1440

cacatgcagg ccctgccccc tcgcggaagc ggagccacca acttcagcct gctgaagcag     1500

gccggcgacg tggaggagaa ccccggcccc atggccttac cagtgaccgc cttgctcctg     1560

ccgctggcct tgctgctcca cgccgccagg ccggacatcc agatgaccca gagccccagc     1620

agcctgagcg ccagcgtggg cgacagggtg accatcacct gcaaggccag ccaggacgtg     1680

ggcatcgccg tggcctggta ccagcagaag cccggcaagg tgcccaagct gctgatctac     1740

tgggccagca ccaggcacac cggcgtgccc gacaggttca gcggcagcgg cagcggcacc     1800

gacttcaccc tgaccatcag cagcctgcag cccgaggacg tggccaccta ctactgccag     1860

cagtacagca gctaccccta caccttcggc cagggcacca aggtggagat caagggaggg     1920

gggggatccg ggggaggagg ctccggcgga ggcggaagcg aggtgcagct ggtggagagc     1980

ggcggcggcc tggtgcagcc cggcggcagc ctgaggctga gctgcgccgc cagcggcttc     2040

ttcagcaggt actggatgag ctgggtgagg caggcccccg gcaagggcct ggagtggatc     2100

ggcgagatca accccgacag cagcaccatc aactacgccc ccagcctgaa ggacaagttc     2160

atcatcagca gggacaacgc caagaacagc ctgtacctgc agatgaacag cctgagggcc     2220

gaggacaccg ccgtgtacta ctgcgccagg cccgacggca actactggta cttcgacgtg     2280

tggggccagg gcaccctggt gaccgtgagc agcaccacga cgccagcgcc gcgaccacca     2340

acaccggcgc ccaccatcgc gtcgcagccc ctgtccctgc gcccagaggc gtgccggcca     2400

gcggcggggg gcgcagtgca cacgaggggg ctggacttcg cctgtgatat ctacatctgg     2460

gcgcccttgg ccgggacttg tggggtcctt ctcctgtcac tggttatcac cctttactgc     2520

aggagtaaga ggagcaggct cctgcacagt gactacatga acatgactcc ccgccgcccc     2580

gggcccaccc gcaagcatta ccagccctat gccccaccac gcgacttcgc agcctatcgc     2640

tccagagtga agttcagcag gagcgcagac gcccccgcgt accagcaggg ccagaaccag     2700

ctctataacg agctcaatct aggacgaaga gaggagtacg atgttttgga caagagacgt     2760

ggccgggacc ctgagatggg gggaaagccg cagagaagga agaaccctca ggaaggcctg     2820

tacaatgaac tgcagaaaga taagatggcg gaggcctaca gtgagattgg gatgaaaggc     2880

gagcgccgga ggggcaaggg gcacgatggc ctttaccagg gtctcagtac agccaccaag     2940

gacacctacg acgcccttca catgcaggcc ctgccccctc gctaagttta aac            2993


<210>  197
<211>  995
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  (BCMA-A7D-CS1-mu90-2G, CD269-A7D-CS1-mu90-2G CAR amino acid 
       sequence)

<400>  197

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Asp Val Val Met Thr Gln Ser His Arg Phe Met 
            20                  25                  30          


Ser Thr Ser Val Gly Asp Arg Val Ser Ile Thr Cys Arg Ala Ser Gln 
        35                  40                  45              


Asp Val Asn Thr Ala Val Ser Trp Tyr Gln Gln Lys Pro Gly Gln Ser 
    50                  55                  60                  


Pro Lys Leu Leu Ile Phe Ser Ala Ser Tyr Arg Tyr Thr Gly Val Pro 
65                  70                  75                  80  


Asp Arg Phe Thr Gly Ser Gly Ser Gly Ala Asp Phe Thr Leu Thr Ile 
                85                  90                  95      


Ser Ser Val Gln Ala Glu Asp Leu Ala Val Tyr Tyr Cys Gln Gln His 
            100                 105                 110         


Tyr Ser Thr Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Asp Ile Lys 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln 
    130                 135                 140                 


Ile Gln Leu Val Gln Ser Gly Pro Asp Leu Lys Lys Pro Gly Glu Thr 
145                 150                 155                 160 


Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Phe Gly 
                165                 170                 175     


Met Asn Trp Val Lys Gln Ala Pro Gly Lys Gly Phe Lys Trp Met Ala 
            180                 185                 190         


Trp Ile Asn Thr Tyr Thr Gly Glu Ser Tyr Phe Ala Asp Asp Phe Lys 
        195                 200                 205             


Gly Arg Phe Ala Phe Ser Val Glu Thr Ser Ala Thr Thr Ala Tyr Leu 
    210                 215                 220                 


Gln Ile Asn Asn Leu Lys Thr Glu Asp Thr Ala Thr Tyr Phe Cys Ala 
225                 230                 235                 240 


Arg Gly Glu Ile Tyr Tyr Gly Tyr Asp Gly Gly Phe Ala Tyr Trp Gly 
                245                 250                 255     


Gln Gly Thr Leu Val Thr Val Ser Ala Thr Thr Thr Pro Ala Pro Arg 
            260                 265                 270         


Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg 
        275                 280                 285             


Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly 
    290                 295                 300                 


Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr 
305                 310                 315                 320 


Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Arg Ser 
                325                 330                 335     


Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg 
            340                 345                 350         


Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg 
        355                 360                 365             


Asp Phe Ala Ala Tyr Arg Ser Arg Val Lys Phe Ser Arg Ser Ala Asp 
    370                 375                 380                 


Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn 
385                 390                 395                 400 


Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg 
                405                 410                 415     


Asp Pro Glu Met Gly Gly Lys Pro Gln Arg Arg Lys Asn Pro Gln Glu 
            420                 425                 430         


Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser 
        435                 440                 445             


Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly 
    450                 455                 460                 


Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu 
465                 470                 475                 480 


His Met Gln Ala Leu Pro Pro Arg Gly Ser Gly Ala Thr Asn Phe Ser 
                485                 490                 495     


Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met Ala 
            500                 505                 510         


Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu His Ala 
        515                 520                 525             


Ala Arg Pro Asp Ile Val Met Thr Gln Ser Gln Lys Ser Met Ser Thr 
    530                 535                 540                 


Ser Val Gly Asp Arg Val Ser Ile Thr Cys Lys Ala Ser Gln Asp Val 
545                 550                 555                 560 


Ile Thr Gly Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys 
                565                 570                 575     


Leu Leu Ile Tyr Ser Ala Ser Tyr Arg Tyr Thr Gly Val Pro Asp Arg 
            580                 585                 590         


Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Asn 
        595                 600                 605             


Val Gln Ala Glu Asp Leu Ala Val Tyr Tyr Cys Gln Gln His Tyr Ser 
    610                 615                 620                 


Thr Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Gly Gly 
625                 630                 635                 640 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln 
                645                 650                 655     


Leu Gln Gln Pro Gly Ala Glu Leu Val Arg Pro Gly Ala Ser Val Lys 
            660                 665                 670         


Leu Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Thr Tyr Trp Met Asn 
        675                 680                 685             


Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile Gly Met Ile 
    690                 695                 700                 


His Pro Ser Asp Ser Glu Thr Arg Leu Asn Lys Phe Lys Asp Lys Ala 
705                 710                 715                 720 


Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr Met Gln Leu Ser 
                725                 730                 735     


Ser Pro Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys Ala Arg Ser Thr 
            740                 745                 750         


Met Ile Ala Thr Arg Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser Val 
        755                 760                 765             


Thr Val Ser Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala 
    770                 775                 780                 


Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg 
785                 790                 795                 800 


Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys 
                805                 810                 815     


Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu 
            820                 825                 830         


Leu Ser Leu Val Ile Thr Leu Tyr Cys Arg Ser Lys Arg Ser Arg Leu 
        835                 840                 845             


Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr 
    850                 855                 860                 


Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr 
865                 870                 875                 880 


Arg Ser Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln 
                885                 890                 895     


Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu 
            900                 905                 910         


Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly 
        915                 920                 925             


Gly Lys Pro Gln Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu 
    930                 935                 940                 


Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys 
945                 950                 955                 960 


Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu 
                965                 970                 975     


Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu 
            980                 985                 990         


Pro Pro Arg 
        995 


<210>  198
<211>  2996
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  (BCMA-A7D-CS1-mu90-2G, CD269-A7D-CS1-mu90-2G CAR nucleotide 
       sequence

<400>  198
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccggacgtgg tgatgaccca gagccacagg ttcatgagca ccagcgtggg cgacagggtg      120

agcatcacct gcagggccag ccaggacgtg aacaccgccg tgagctggta ccagcagaag      180

cccggccaga gccccaagct gctgatcttc agcgccagct acaggtacac cggcgtgccc      240

gacaggttca ccggcagcgg cagcggcgcc gacttcaccc tgaccatcag cagcgtgcag      300

gccgaggacc tggccgtgta ctactgccag cagcactaca gcaccccctg gaccttcggc      360

ggcggcacca agctggacat caagggaggg gggggatccg ggggaggagg ctccggcgga      420

ggcggaagcc agatccagct ggtgcagagc ggccccgacc tgaagaagcc cggcgagacc      480

gtgaagctga gctgcaaggc cagcggctac accttcacca acttcggcat gaactgggtg      540

aagcaggccc ccggcaaggg cttcaagtgg atggcctgga tcaacaccta caccggcgag      600

agctacttcg ccgacgactt caagggcagg ttcgccttca gcgtggagac cagcgccacc      660

accgcctacc tgcagatcaa caacctgaag accgaggaca ccgccaccta cttctgcgcc      720

aggggcgaga tctactacgg ctacgacggc ggcttcgcct actggggcca gggcaccctg      780

gtgaccgtga gcgccaccac gacgccagcg ccgcgaccac caacaccggc gcccaccatc      840

gcgtcgcagc ccctgtccct gcgcccagag gcgtgccggc cagcggcggg gggcgcagtg      900

cacacgaggg ggctggactt cgcctgtgat atctacatct gggcgccctt ggccgggact      960

tgtggggtcc ttctcctgtc actggttatc accctttact gcaggagtaa gaggagcagg     1020

ctcctgcaca gtgactacat gaacatgact ccccgccgcc ccgggcccac ccgcaagcat     1080

taccagccct atgccccacc acgcgacttc gcagcctatc gctccagagt gaagttcagc     1140

aggagcgcag acgcccccgc gtaccagcag ggccagaacc agctctataa cgagctcaat     1200

ctaggacgaa gagaggagta cgatgttttg gacaagagac gtggccggga ccctgagatg     1260

gggggaaagc cgcagagaag gaagaaccct caggaaggcc tgtacaatga actgcagaaa     1320

gataagatgg cggaggccta cagtgagatt gggatgaaag gcgagcgccg gaggggcaag     1380

gggcacgatg gcctttacca gggtctcagt acagccacca aggacaccta cgacgccctt     1440

cacatgcagg ccctgccccc tcgcggaagc ggagccacca acttcagcct gctgaagcag     1500

gccggcgacg tggaggagaa ccccggcccc atggccttac cagtgaccgc cttgctcctg     1560

ccgctggcct tgctgctcca cgccgccagg ccggacatcg tgatgaccca gagccagaag     1620

agcatgagca ccagcgtggg cgacagggtg agcatcacct gcaaggccag ccaggacgtg     1680

atcaccggcg tggcctggta ccagcagaag cccggccaga gccccaagct gctgatctac     1740

agcgccagct acaggtacac cggcgtgccc gacaggttca ccggcagcgg cagcggcacc     1800

gacttcacct tcaccatcag caacgtgcag gccgaggacc tggccgtgta ctactgccag     1860

cagcactaca gcacccccct gaccttcggc gccggcacca agctggagct gaagggaggg     1920

gggggatccg ggggaggagg ctccggcgga ggcggaagcc aggtgcagct gcagcagccc     1980

ggcgccgagc tggtgaggcc cggcgccagc gtgaagctga gctgcaaggc cagcggctac     2040

agcttcacca cctactggat gaactgggtg aagcagaggc ccggccaggg cctggagtgg     2100

atcggcatga tccaccccag cgacagcgag accaggctga acaagttcaa ggacaaggcc     2160

accctgaccg tggacaagag cagcagcacc gcctacatgc agctgagcag ccccaccagc     2220

gaggacagcg ccgtgtacta ctgcgccagg agcaccatga tcgccaccag ggccatggac     2280

tactggggcc agggcaccag cgtgaccgtg agcagcacca cgacgccagc gccgcgacca     2340

ccaacaccgg cgcccaccat cgcgtcgcag cccctgtccc tgcgcccaga ggcgtgccgg     2400

ccagcggcgg ggggcgcagt gcacacgagg gggctggact tcgcctgtga tatctacatc     2460

tgggcgccct tggccgggac ttgtggggtc cttctcctgt cactggttat caccctttac     2520

tgcaggagta agaggagcag gctcctgcac agtgactaca tgaacatgac tccccgccgc     2580

cccgggccca cccgcaagca ttaccagccc tatgccccac cacgcgactt cgcagcctat     2640

cgctccagag tgaagttcag caggagcgca gacgcccccg cgtaccagca gggccagaac     2700

cagctctata acgagctcaa tctaggacga agagaggagt acgatgtttt ggacaagaga     2760

cgtggccggg accctgagat ggggggaaag ccgcagagaa ggaagaaccc tcaggaaggc     2820

ctgtacaatg aactgcagaa agataagatg gcggaggcct acagtgagat tgggatgaaa     2880

ggcgagcgcc ggaggggcaa ggggcacgat ggcctttacc agggtctcag tacagccacc     2940

aaggacacct acgacgccct tcacatgcag gccctgcccc ctcgctaagt ttaaac         2996


<210>  199
<211>  993
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  (BCMA-C11D-CS1-hu63-2G, CD269-C11D-CS1-hu63-2G CAR amino acid 
       sequence)

<400>  199

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Asp Ile Val Leu Thr Gln Ser Pro Pro Ser Leu 
            20                  25                  30          


Ala Met Ser Leu Gly Lys Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu 
        35                  40                  45              


Ser Val Thr Ile Leu Gly Ser His Leu Ile His Trp Tyr Gln Gln Lys 
    50                  55                  60                  


Pro Gly Gln Pro Pro Thr Leu Leu Ile Gln Leu Ala Ser Asn Val Gln 
65                  70                  75                  80  


Thr Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Arg Thr Asp Phe 
                85                  90                  95      


Thr Leu Thr Ile Asp Pro Val Glu Glu Asp Asp Val Ala Val Tyr Tyr 
            100                 105                 110         


Cys Leu Gln Ser Arg Thr Ile Pro Arg Thr Phe Gly Gly Gly Thr Lys 
        115                 120                 125             


Leu Glu Ile Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Gln Ile Gln Leu Val Gln Ser Gly Pro Glu Leu Lys Lys 
145                 150                 155                 160 


Pro Gly Glu Thr Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
                165                 170                 175     


Thr Asp Tyr Ser Ile Asn Trp Val Lys Arg Ala Pro Gly Lys Gly Leu 
            180                 185                 190         


Lys Trp Met Gly Trp Ile Asn Thr Glu Thr Arg Glu Pro Ala Tyr Ala 
        195                 200                 205             


Tyr Asp Phe Arg Gly Arg Phe Ala Phe Ser Leu Glu Thr Ser Ala Ser 
    210                 215                 220                 


Thr Ala Tyr Leu Gln Ile Asn Asn Leu Lys Tyr Glu Asp Thr Ala Thr 
225                 230                 235                 240 


Tyr Phe Cys Ala Leu Asp Tyr Ser Tyr Ala Met Asp Tyr Trp Gly Gln 
                245                 250                 255     


Gly Thr Ser Val Thr Val Ser Ser Thr Thr Thr Pro Ala Pro Arg Pro 
            260                 265                 270         


Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro 
        275                 280                 285             


Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu 
    290                 295                 300                 


Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys 
305                 310                 315                 320 


Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Arg Ser Lys 
                325                 330                 335     


Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg 
            340                 345                 350         


Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp 
        355                 360                 365             


Phe Ala Ala Tyr Arg Ser Arg Val Lys Phe Ser Arg Ser Ala Asp Ala 
    370                 375                 380                 


Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu 
385                 390                 395                 400 


Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp 
                405                 410                 415     


Pro Glu Met Gly Gly Lys Pro Gln Arg Arg Lys Asn Pro Gln Glu Gly 
            420                 425                 430         


Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu 
        435                 440                 445             


Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu 
    450                 455                 460                 


Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His 
465                 470                 475                 480 


Met Gln Ala Leu Pro Pro Arg Gly Ser Gly Ala Thr Asn Phe Ser Leu 
                485                 490                 495     


Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met Ala Leu 
            500                 505                 510         


Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu His Ala Ala 
        515                 520                 525             


Arg Pro Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser 
    530                 535                 540                 


Val Gly Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Val Gly 
545                 550                 555                 560 


Ile Ala Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Val Pro Lys Leu 
                565                 570                 575     


Leu Ile Tyr Trp Ala Ser Thr Arg His Thr Gly Val Pro Asp Arg Phe 
            580                 585                 590         


Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu 
        595                 600                 605             


Gln Pro Glu Asp Val Ala Thr Tyr Tyr Cys Gln Gln Tyr Ser Ser Tyr 
    610                 615                 620                 


Pro Tyr Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Gly Gly Gly 
625                 630                 635                 640 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu 
                645                 650                 655     


Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu 
            660                 665                 670         


Ser Cys Ala Ala Ser Gly Phe Phe Ser Arg Tyr Trp Met Ser Trp Val 
        675                 680                 685             


Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Gly Glu Ile Asn Pro 
    690                 695                 700                 


Asp Ser Ser Thr Ile Asn Tyr Ala Pro Ser Leu Lys Asp Lys Phe Ile 
705                 710                 715                 720 


Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr Leu Gln Met Asn Ser 
                725                 730                 735     


Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Pro Asp Gly 
            740                 745                 750         


Asn Tyr Trp Tyr Phe Asp Val Trp Gly Gln Gly Thr Leu Val Thr Val 
        755                 760                 765             


Ser Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr 
    770                 775                 780                 


Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala 
785                 790                 795                 800 


Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile 
                805                 810                 815     


Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser 
            820                 825                 830         


Leu Val Ile Thr Leu Tyr Cys Arg Ser Lys Arg Ser Arg Leu Leu His 
        835                 840                 845             


Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys 
    850                 855                 860                 


His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser 
865                 870                 875                 880 


Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly 
                885                 890                 895     


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
            900                 905                 910         


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
        915                 920                 925             


Pro Gln Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln 
    930                 935                 940                 


Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu 
945                 950                 955                 960 


Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr 
                965                 970                 975     


Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro 
            980                 985                 990         


Arg 
    


<210>  200
<211>  2990
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  (BCMA-C11D-CS1-hu63-2G, CD269-C11D-CS1-hu63-2G CAR nucleotide 
       sequence)

<400>  200
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccggacatcg tgctgaccca gagccccccc agcctggcca tgagcctggg caagagggcc      120

accatcagct gcagggccag cgagagcgtg accatcctgg gcagccacct gatccactgg      180

taccagcaga agcccggcca gccccccacc ctgctgatcc agctggccag caacgtgcag      240

accggcgtgc ccgccaggtt cagcggcagc ggcagcagga ccgacttcac cctgaccatc      300

gaccccgtgg aggaggacga cgtggccgtg tactactgcc tgcagagcag gaccatcccc      360

aggaccttcg gcggcggcac caagctggag atcaagggag gggggggatc cgggggagga      420

ggctccggcg gaggcggaag ccagatccag ctggtgcaga gcggccccga gctgaagaag      480

cccggcgaga ccgtgaagat cagctgcaag gccagcggct acaccttcac cgactacagc      540

atcaactggg tgaagagggc ccccggcaag ggcctgaagt ggatgggctg gatcaacacc      600

gagaccaggg agcccgccta cgcctacgac ttcaggggca ggttcgcctt cagcctggag      660

accagcgcca gcaccgccta cctgcagatc aacaacctga agtacgagga caccgccacc      720

tacttctgcg ccctggacta cagctacgcc atggactact ggggccaggg caccagcgtg      780

accgtgagca gcaccacgac gccagcgccg cgaccaccaa caccggcgcc caccatcgcg      840

tcgcagcccc tgtccctgcg cccagaggcg tgccggccag cggcgggggg cgcagtgcac      900

acgagggggc tggacttcgc ctgtgatatc tacatctggg cgcccttggc cgggacttgt      960

ggggtccttc tcctgtcact ggttatcacc ctttactgca ggagtaagag gagcaggctc     1020

ctgcacagtg actacatgaa catgactccc cgccgccccg ggcccacccg caagcattac     1080

cagccctatg ccccaccacg cgacttcgca gcctatcgct ccagagtgaa gttcagcagg     1140

agcgcagacg cccccgcgta ccagcagggc cagaaccagc tctataacga gctcaatcta     1200

ggacgaagag aggagtacga tgttttggac aagagacgtg gccgggaccc tgagatgggg     1260

ggaaagccgc agagaaggaa gaaccctcag gaaggcctgt acaatgaact gcagaaagat     1320

aagatggcgg aggcctacag tgagattggg atgaaaggcg agcgccggag gggcaagggg     1380

cacgatggcc tttaccaggg tctcagtaca gccaccaagg acacctacga cgcccttcac     1440

atgcaggccc tgccccctcg cggaagcgga gccaccaact tcagcctgct gaagcaggcc     1500

ggcgacgtgg aggagaaccc cggccccatg gccttaccag tgaccgcctt gctcctgccg     1560

ctggccttgc tgctccacgc cgccaggccg gacatccaga tgacccagag ccccagcagc     1620

ctgagcgcca gcgtgggcga cagggtgacc atcacctgca aggccagcca ggacgtgggc     1680

atcgccgtgg cctggtacca gcagaagccc ggcaaggtgc ccaagctgct gatctactgg     1740

gccagcacca ggcacaccgg cgtgcccgac aggttcagcg gcagcggcag cggcaccgac     1800

ttcaccctga ccatcagcag cctgcagccc gaggacgtgg ccacctacta ctgccagcag     1860

tacagcagct acccctacac cttcggccag ggcaccaagg tggagatcaa gggagggggg     1920

ggatccgggg gaggaggctc cggcggaggc ggaagcgagg tgcagctggt ggagagcggc     1980

ggcggcctgg tgcagcccgg cggcagcctg aggctgagct gcgccgccag cggcttcttc     2040

agcaggtact ggatgagctg ggtgaggcag gcccccggca agggcctgga gtggatcggc     2100

gagatcaacc ccgacagcag caccatcaac tacgccccca gcctgaagga caagttcatc     2160

atcagcaggg acaacgccaa gaacagcctg tacctgcaga tgaacagcct gagggccgag     2220

gacaccgccg tgtactactg cgccaggccc gacggcaact actggtactt cgacgtgtgg     2280

ggccagggca ccctggtgac cgtgagcagc accacgacgc cagcgccgcg accaccaaca     2340

ccggcgccca ccatcgcgtc gcagcccctg tccctgcgcc cagaggcgtg ccggccagcg     2400

gcggggggcg cagtgcacac gagggggctg gacttcgcct gtgatatcta catctgggcg     2460

cccttggccg ggacttgtgg ggtccttctc ctgtcactgg ttatcaccct ttactgcagg     2520

agtaagagga gcaggctcct gcacagtgac tacatgaaca tgactccccg ccgccccggg     2580

cccacccgca agcattacca gccctatgcc ccaccacgcg acttcgcagc ctatcgctcc     2640

agagtgaagt tcagcaggag cgcagacgcc cccgcgtacc agcagggcca gaaccagctc     2700

tataacgagc tcaatctagg acgaagagag gagtacgatg ttttggacaa gagacgtggc     2760

cgggaccctg agatgggggg aaagccgcag agaaggaaga accctcagga aggcctgtac     2820

aatgaactgc agaaagataa gatggcggag gcctacagtg agattgggat gaaaggcgag     2880

cgccggaggg gcaaggggca cgatggcctt taccagggtc tcagtacagc caccaaggac     2940

acctacgacg cccttcacat gcaggccctg ccccctcgct aagtttaaac                2990


<210>  201
<211>  996
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  (BCMA-C11D-CS1-mu34-2G, CD269-C11D-CS1-mu34-2G CAR amino acid 
       sequence)

<400>  201

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Asp Ile Val Leu Thr Gln Ser Pro Pro Ser Leu 
            20                  25                  30          


Ala Met Ser Leu Gly Lys Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu 
        35                  40                  45              


Ser Val Thr Ile Leu Gly Ser His Leu Ile His Trp Tyr Gln Gln Lys 
    50                  55                  60                  


Pro Gly Gln Pro Pro Thr Leu Leu Ile Gln Leu Ala Ser Asn Val Gln 
65                  70                  75                  80  


Thr Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Arg Thr Asp Phe 
                85                  90                  95      


Thr Leu Thr Ile Asp Pro Val Glu Glu Asp Asp Val Ala Val Tyr Tyr 
            100                 105                 110         


Cys Leu Gln Ser Arg Thr Ile Pro Arg Thr Phe Gly Gly Gly Thr Lys 
        115                 120                 125             


Leu Glu Ile Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Gln Ile Gln Leu Val Gln Ser Gly Pro Glu Leu Lys Lys 
145                 150                 155                 160 


Pro Gly Glu Thr Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
                165                 170                 175     


Thr Asp Tyr Ser Ile Asn Trp Val Lys Arg Ala Pro Gly Lys Gly Leu 
            180                 185                 190         


Lys Trp Met Gly Trp Ile Asn Thr Glu Thr Arg Glu Pro Ala Tyr Ala 
        195                 200                 205             


Tyr Asp Phe Arg Gly Arg Phe Ala Phe Ser Leu Glu Thr Ser Ala Ser 
    210                 215                 220                 


Thr Ala Tyr Leu Gln Ile Asn Asn Leu Lys Tyr Glu Asp Thr Ala Thr 
225                 230                 235                 240 


Tyr Phe Cys Ala Leu Asp Tyr Ser Tyr Ala Met Asp Tyr Trp Gly Gln 
                245                 250                 255     


Gly Thr Ser Val Thr Val Ser Ser Thr Thr Thr Pro Ala Pro Arg Pro 
            260                 265                 270         


Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro 
        275                 280                 285             


Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu 
    290                 295                 300                 


Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys 
305                 310                 315                 320 


Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Arg Ser Lys 
                325                 330                 335     


Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg 
            340                 345                 350         


Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp 
        355                 360                 365             


Phe Ala Ala Tyr Arg Ser Arg Val Lys Phe Ser Arg Ser Ala Asp Ala 
    370                 375                 380                 


Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu 
385                 390                 395                 400 


Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp 
                405                 410                 415     


Pro Glu Met Gly Gly Lys Pro Gln Arg Arg Lys Asn Pro Gln Glu Gly 
            420                 425                 430         


Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu 
        435                 440                 445             


Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu 
    450                 455                 460                 


Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His 
465                 470                 475                 480 


Met Gln Ala Leu Pro Pro Arg Gly Ser Gly Ala Thr Asn Phe Ser Leu 
                485                 490                 495     


Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met Ala Leu 
            500                 505                 510         


Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu His Ala Ala 
        515                 520                 525             


Arg Pro Asp Ile Gln Met Thr Gln Ser Ser Ser Tyr Leu Ser Val Ser 
    530                 535                 540                 


Leu Gly Gly Arg Val Thr Ile Thr Cys Lys Ala Ser Asp His Ile Asn 
545                 550                 555                 560 


Asn Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Asn Ala Pro Arg Leu 
                565                 570                 575     


Leu Ile Ser Gly Ala Thr Ser Leu Glu Thr Gly Val Pro Ser Arg Phe 
            580                 585                 590         


Ser Gly Ser Gly Ser Gly Lys Asp Tyr Thr Leu Ser Ile Thr Ser Leu 
        595                 600                 605             


Gln Thr Glu Asp Val Ala Thr Tyr Tyr Cys Gln Gln Tyr Trp Ser Thr 
    610                 615                 620                 


Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Gly Gly Gly 
625                 630                 635                 640 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu 
                645                 650                 655     


Gln Gln Ser Gly Ala Glu Leu Ala Arg Pro Gly Ala Ser Val Lys Leu 
            660                 665                 670         


Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr Trp Met Gln Trp 
        675                 680                 685             


Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile Gly Ala Ile Tyr 
    690                 695                 700                 


Pro Gly Asp Gly Asp Thr Arg Tyr Thr Gln Lys Phe Lys Gly Lys Ala 
705                 710                 715                 720 


Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr Met Gln Leu Ser 
                725                 730                 735     


Ser Leu Ala Ser Glu Asp Ser Ala Val Tyr Tyr Cys Ala Arg Gly Lys 
            740                 745                 750         


Val Tyr Tyr Gly Ser Asn Pro Phe Ala Tyr Trp Gly Gln Gly Thr Leu 
        755                 760                 765             


Val Thr Val Ser Ala Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro 
    770                 775                 780                 


Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys 
785                 790                 795                 800 


Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala 
                805                 810                 815     


Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu 
            820                 825                 830         


Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Arg Ser Lys Arg Ser Arg 
        835                 840                 845             


Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro 
    850                 855                 860                 


Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala 
865                 870                 875                 880 


Tyr Arg Ser Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr 
                885                 890                 895     


Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg 
            900                 905                 910         


Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met 
        915                 920                 925             


Gly Gly Lys Pro Gln Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn 
    930                 935                 940                 


Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met 
945                 950                 955                 960 


Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly 
                965                 970                 975     


Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala 
            980                 985                 990         


Leu Pro Pro Arg 
        995     


<210>  202
<211>  2999
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  (BCMA-C11D-CS1-mu34-2G, CD269-C11D-CS1-mu34-2G CAR nucleotide 
       sequence)

<400>  202
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccggacatcg tgctgaccca gagccccccc agcctggcca tgagcctggg caagagggcc      120

accatcagct gcagggccag cgagagcgtg accatcctgg gcagccacct gatccactgg      180

taccagcaga agcccggcca gccccccacc ctgctgatcc agctggccag caacgtgcag      240

accggcgtgc ccgccaggtt cagcggcagc ggcagcagga ccgacttcac cctgaccatc      300

gaccccgtgg aggaggacga cgtggccgtg tactactgcc tgcagagcag gaccatcccc      360

aggaccttcg gcggcggcac caagctggag atcaagggag gggggggatc cgggggagga      420

ggctccggcg gaggcggaag ccagatccag ctggtgcaga gcggccccga gctgaagaag      480

cccggcgaga ccgtgaagat cagctgcaag gccagcggct acaccttcac cgactacagc      540

atcaactggg tgaagagggc ccccggcaag ggcctgaagt ggatgggctg gatcaacacc      600

gagaccaggg agcccgccta cgcctacgac ttcaggggca ggttcgcctt cagcctggag      660

accagcgcca gcaccgccta cctgcagatc aacaacctga agtacgagga caccgccacc      720

tacttctgcg ccctggacta cagctacgcc atggactact ggggccaggg caccagcgtg      780

accgtgagca gcaccacgac gccagcgccg cgaccaccaa caccggcgcc caccatcgcg      840

tcgcagcccc tgtccctgcg cccagaggcg tgccggccag cggcgggggg cgcagtgcac      900

acgagggggc tggacttcgc ctgtgatatc tacatctggg cgcccttggc cgggacttgt      960

ggggtccttc tcctgtcact ggttatcacc ctttactgca ggagtaagag gagcaggctc     1020

ctgcacagtg actacatgaa catgactccc cgccgccccg ggcccacccg caagcattac     1080

cagccctatg ccccaccacg cgacttcgca gcctatcgct ccagagtgaa gttcagcagg     1140

agcgcagacg cccccgcgta ccagcagggc cagaaccagc tctataacga gctcaatcta     1200

ggacgaagag aggagtacga tgttttggac aagagacgtg gccgggaccc tgagatgggg     1260

ggaaagccgc agagaaggaa gaaccctcag gaaggcctgt acaatgaact gcagaaagat     1320

aagatggcgg aggcctacag tgagattggg atgaaaggcg agcgccggag gggcaagggg     1380

cacgatggcc tttaccaggg tctcagtaca gccaccaagg acacctacga cgcccttcac     1440

atgcaggccc tgccccctcg cggaagcgga gccaccaact tcagcctgct gaagcaggcc     1500

ggcgacgtgg aggagaaccc cggccccatg gccttaccag tgaccgcctt gctcctgccg     1560

ctggccttgc tgctccacgc cgccaggccg gacatccaga tgacccagag cagcagctac     1620

ctgagcgtga gcctgggcgg cagggtgacc atcacctgca aggccagcga ccacatcaac     1680

aactggctgg cctggtacca gcagaagccc ggcaacgccc ccaggctgct gatcagcggc     1740

gccaccagcc tggagaccgg cgtgcccagc aggttcagcg gcagcggcag cggcaaggac     1800

tacaccctga gcatcaccag cctgcagacc gaggacgtgg ccacctacta ctgccagcag     1860

tactggagca ccccctggac cttcggcggc ggcaccaagc tggagatcaa gggagggggg     1920

ggatccgggg gaggaggctc cggcggaggc ggaagccagg tgcagctgca gcagagcggc     1980

gccgagctgg ccaggcccgg cgccagcgtg aagctgagct gcaaggccag cggctacacc     2040

ttcaccagct actggatgca gtgggtgaag cagaggcccg gccagggcct ggagtggatc     2100

ggcgccatct accccggcga cggcgacacc aggtacaccc agaagttcaa gggcaaggcc     2160

accctgaccg ccgacaagag cagcagcacc gcctacatgc agctgagcag cctggccagc     2220

gaggacagcg ccgtgtacta ctgcgccagg ggcaaggtgt actacggcag caaccccttc     2280

gcctactggg gccagggcac cctggtgacc gtgagcgcca ccacgacgcc agcgccgcga     2340

ccaccaacac cggcgcccac catcgcgtcg cagcccctgt ccctgcgccc agaggcgtgc     2400

cggccagcgg cggggggcgc agtgcacacg agggggctgg acttcgcctg tgatatctac     2460

atctgggcgc ccttggccgg gacttgtggg gtccttctcc tgtcactggt tatcaccctt     2520

tactgcagga gtaagaggag caggctcctg cacagtgact acatgaacat gactccccgc     2580

cgccccgggc ccacccgcaa gcattaccag ccctatgccc caccacgcga cttcgcagcc     2640

tatcgctcca gagtgaagtt cagcaggagc gcagacgccc ccgcgtacca gcagggccag     2700

aaccagctct ataacgagct caatctagga cgaagagagg agtacgatgt tttggacaag     2760

agacgtggcc gggaccctga gatgggggga aagccgcaga gaaggaagaa ccctcaggaa     2820

ggcctgtaca atgaactgca gaaagataag atggcggagg cctacagtga gattgggatg     2880

aaaggcgagc gccggagggg caaggggcac gatggccttt accagggtct cagtacagcc     2940

accaaggaca cctacgacgc ccttcacatg caggccctgc cccctcgcta agtttaaac      2999


<210>  203
<211>  994
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BCMA-C11D-CS1-mu90-2G, CD269-C11D-CS1-mu90-2G CAR amino acid 
       sequence)

<400>  203

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Asp Ile Val Leu Thr Gln Ser Pro Pro Ser Leu 
            20                  25                  30          


Ala Met Ser Leu Gly Lys Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu 
        35                  40                  45              


Ser Val Thr Ile Leu Gly Ser His Leu Ile His Trp Tyr Gln Gln Lys 
    50                  55                  60                  


Pro Gly Gln Pro Pro Thr Leu Leu Ile Gln Leu Ala Ser Asn Val Gln 
65                  70                  75                  80  


Thr Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Arg Thr Asp Phe 
                85                  90                  95      


Thr Leu Thr Ile Asp Pro Val Glu Glu Asp Asp Val Ala Val Tyr Tyr 
            100                 105                 110         


Cys Leu Gln Ser Arg Thr Ile Pro Arg Thr Phe Gly Gly Gly Thr Lys 
        115                 120                 125             


Leu Glu Ile Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Gln Ile Gln Leu Val Gln Ser Gly Pro Glu Leu Lys Lys 
145                 150                 155                 160 


Pro Gly Glu Thr Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
                165                 170                 175     


Thr Asp Tyr Ser Ile Asn Trp Val Lys Arg Ala Pro Gly Lys Gly Leu 
            180                 185                 190         


Lys Trp Met Gly Trp Ile Asn Thr Glu Thr Arg Glu Pro Ala Tyr Ala 
        195                 200                 205             


Tyr Asp Phe Arg Gly Arg Phe Ala Phe Ser Leu Glu Thr Ser Ala Ser 
    210                 215                 220                 


Thr Ala Tyr Leu Gln Ile Asn Asn Leu Lys Tyr Glu Asp Thr Ala Thr 
225                 230                 235                 240 


Tyr Phe Cys Ala Leu Asp Tyr Ser Tyr Ala Met Asp Tyr Trp Gly Gln 
                245                 250                 255     


Gly Thr Ser Val Thr Val Ser Ser Thr Thr Thr Pro Ala Pro Arg Pro 
            260                 265                 270         


Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro 
        275                 280                 285             


Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu 
    290                 295                 300                 


Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys 
305                 310                 315                 320 


Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Arg Ser Lys 
                325                 330                 335     


Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg 
            340                 345                 350         


Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp 
        355                 360                 365             


Phe Ala Ala Tyr Arg Ser Arg Val Lys Phe Ser Arg Ser Ala Asp Ala 
    370                 375                 380                 


Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu 
385                 390                 395                 400 


Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp 
                405                 410                 415     


Pro Glu Met Gly Gly Lys Pro Gln Arg Arg Lys Asn Pro Gln Glu Gly 
            420                 425                 430         


Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu 
        435                 440                 445             


Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu 
    450                 455                 460                 


Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His 
465                 470                 475                 480 


Met Gln Ala Leu Pro Pro Arg Gly Ser Gly Ala Thr Asn Phe Ser Leu 
                485                 490                 495     


Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met Ala Leu 
            500                 505                 510         


Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu His Ala Ala 
        515                 520                 525             


Arg Pro Asp Ile Val Met Thr Gln Ser Gln Lys Ser Met Ser Thr Ser 
    530                 535                 540                 


Val Gly Asp Arg Val Ser Ile Thr Cys Lys Ala Ser Gln Asp Val Ile 
545                 550                 555                 560 


Thr Gly Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu 
                565                 570                 575     


Leu Ile Tyr Ser Ala Ser Tyr Arg Tyr Thr Gly Val Pro Asp Arg Phe 
            580                 585                 590         


Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Asn Val 
        595                 600                 605             


Gln Ala Glu Asp Leu Ala Val Tyr Tyr Cys Gln Gln His Tyr Ser Thr 
    610                 615                 620                 


Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Gly Gly Gly 
625                 630                 635                 640 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu 
                645                 650                 655     


Gln Gln Pro Gly Ala Glu Leu Val Arg Pro Gly Ala Ser Val Lys Leu 
            660                 665                 670         


Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Thr Tyr Trp Met Asn Trp 
        675                 680                 685             


Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile Gly Met Ile His 
    690                 695                 700                 


Pro Ser Asp Ser Glu Thr Arg Leu Asn Lys Phe Lys Asp Lys Ala Thr 
705                 710                 715                 720 


Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr Met Gln Leu Ser Ser 
                725                 730                 735     


Pro Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys Ala Arg Ser Thr Met 
            740                 745                 750         


Ile Ala Thr Arg Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr 
        755                 760                 765             


Val Ser Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro 
    770                 775                 780                 


Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro 
785                 790                 795                 800 


Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp 
                805                 810                 815     


Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu 
            820                 825                 830         


Ser Leu Val Ile Thr Leu Tyr Cys Arg Ser Lys Arg Ser Arg Leu Leu 
        835                 840                 845             


His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg 
    850                 855                 860                 


Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg 
865                 870                 875                 880 


Ser Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln 
                885                 890                 895     


Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu 
            900                 905                 910         


Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly 
        915                 920                 925             


Lys Pro Gln Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu 
    930                 935                 940                 


Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly 
945                 950                 955                 960 


Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser 
                965                 970                 975     


Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro 
            980                 985                 990         


Pro Arg 
        


<210>  204
<211>  2993
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  (BCMA-C11D-CS1-mu90-2G, CD269-C11D-CS1-mu90-2G CAR nucleotide 
       sequence)

<400>  204
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccggacatcg tgctgaccca gagccccccc agcctggcca tgagcctggg caagagggcc      120

accatcagct gcagggccag cgagagcgtg accatcctgg gcagccacct gatccactgg      180

taccagcaga agcccggcca gccccccacc ctgctgatcc agctggccag caacgtgcag      240

accggcgtgc ccgccaggtt cagcggcagc ggcagcagga ccgacttcac cctgaccatc      300

gaccccgtgg aggaggacga cgtggccgtg tactactgcc tgcagagcag gaccatcccc      360

aggaccttcg gcggcggcac caagctggag atcaagggag gggggggatc cgggggagga      420

ggctccggcg gaggcggaag ccagatccag ctggtgcaga gcggccccga gctgaagaag      480

cccggcgaga ccgtgaagat cagctgcaag gccagcggct acaccttcac cgactacagc      540

atcaactggg tgaagagggc ccccggcaag ggcctgaagt ggatgggctg gatcaacacc      600

gagaccaggg agcccgccta cgcctacgac ttcaggggca ggttcgcctt cagcctggag      660

accagcgcca gcaccgccta cctgcagatc aacaacctga agtacgagga caccgccacc      720

tacttctgcg ccctggacta cagctacgcc atggactact ggggccaggg caccagcgtg      780

accgtgagca gcaccacgac gccagcgccg cgaccaccaa caccggcgcc caccatcgcg      840

tcgcagcccc tgtccctgcg cccagaggcg tgccggccag cggcgggggg cgcagtgcac      900

acgagggggc tggacttcgc ctgtgatatc tacatctggg cgcccttggc cgggacttgt      960

ggggtccttc tcctgtcact ggttatcacc ctttactgca ggagtaagag gagcaggctc     1020

ctgcacagtg actacatgaa catgactccc cgccgccccg ggcccacccg caagcattac     1080

cagccctatg ccccaccacg cgacttcgca gcctatcgct ccagagtgaa gttcagcagg     1140

agcgcagacg cccccgcgta ccagcagggc cagaaccagc tctataacga gctcaatcta     1200

ggacgaagag aggagtacga tgttttggac aagagacgtg gccgggaccc tgagatgggg     1260

ggaaagccgc agagaaggaa gaaccctcag gaaggcctgt acaatgaact gcagaaagat     1320

aagatggcgg aggcctacag tgagattggg atgaaaggcg agcgccggag gggcaagggg     1380

cacgatggcc tttaccaggg tctcagtaca gccaccaagg acacctacga cgcccttcac     1440

atgcaggccc tgccccctcg cggaagcgga gccaccaact tcagcctgct gaagcaggcc     1500

ggcgacgtgg aggagaaccc cggccccatg gccttaccag tgaccgcctt gctcctgccg     1560

ctggccttgc tgctccacgc cgccaggccg gacatcgtga tgacccagag ccagaagagc     1620

atgagcacca gcgtgggcga cagggtgagc atcacctgca aggccagcca ggacgtgatc     1680

accggcgtgg cctggtacca gcagaagccc ggccagagcc ccaagctgct gatctacagc     1740

gccagctaca ggtacaccgg cgtgcccgac aggttcaccg gcagcggcag cggcaccgac     1800

ttcaccttca ccatcagcaa cgtgcaggcc gaggacctgg ccgtgtacta ctgccagcag     1860

cactacagca cccccctgac cttcggcgcc ggcaccaagc tggagctgaa gggagggggg     1920

ggatccgggg gaggaggctc cggcggaggc ggaagccagg tgcagctgca gcagcccggc     1980

gccgagctgg tgaggcccgg cgccagcgtg aagctgagct gcaaggccag cggctacagc     2040

ttcaccacct actggatgaa ctgggtgaag cagaggcccg gccagggcct ggagtggatc     2100

ggcatgatcc accccagcga cagcgagacc aggctgaaca agttcaagga caaggccacc     2160

ctgaccgtgg acaagagcag cagcaccgcc tacatgcagc tgagcagccc caccagcgag     2220

gacagcgccg tgtactactg cgccaggagc accatgatcg ccaccagggc catggactac     2280

tggggccagg gcaccagcgt gaccgtgagc agcaccacga cgccagcgcc gcgaccacca     2340

acaccggcgc ccaccatcgc gtcgcagccc ctgtccctgc gcccagaggc gtgccggcca     2400

gcggcggggg gcgcagtgca cacgaggggg ctggacttcg cctgtgatat ctacatctgg     2460

gcgcccttgg ccgggacttg tggggtcctt ctcctgtcac tggttatcac cctttactgc     2520

aggagtaaga ggagcaggct cctgcacagt gactacatga acatgactcc ccgccgcccc     2580

gggcccaccc gcaagcatta ccagccctat gccccaccac gcgacttcgc agcctatcgc     2640

tccagagtga agttcagcag gagcgcagac gcccccgcgt accagcaggg ccagaaccag     2700

ctctataacg agctcaatct aggacgaaga gaggagtacg atgttttgga caagagacgt     2760

ggccgggacc ctgagatggg gggaaagccg cagagaagga agaaccctca ggaaggcctg     2820

tacaatgaac tgcagaaaga taagatggcg gaggcctaca gtgagattgg gatgaaaggc     2880

gagcgccgga ggggcaaggg gcacgatggc ctttaccagg gtctcagtac agccaccaag     2940

gacacctacg acgcccttca catgcaggcc ctgccccctc gctaagttta aac            2993


<210>  205
<211>  1293
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  (BCMA-CS1-BB-IL-15/IL-15sushi, CD269-CS1-BB-IL-15/IL-15sushi CAR 
       amino acid sequence)

<400>  205

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Asp Val Val Met Thr Gln Ser His Arg Phe Met 
            20                  25                  30          


Ser Thr Ser Val Gly Asp Arg Val Ser Ile Thr Cys Arg Ala Ser Gln 
        35                  40                  45              


Asp Val Asn Thr Ala Val Ser Trp Tyr Gln Gln Lys Pro Gly Gln Ser 
    50                  55                  60                  


Pro Lys Leu Leu Ile Phe Ser Ala Ser Tyr Arg Tyr Thr Gly Val Pro 
65                  70                  75                  80  


Asp Arg Phe Thr Gly Ser Gly Ser Gly Ala Asp Phe Thr Leu Thr Ile 
                85                  90                  95      


Ser Ser Val Gln Ala Glu Asp Leu Ala Val Tyr Tyr Cys Gln Gln His 
            100                 105                 110         


Tyr Ser Thr Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Asp Ile Lys 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln 
    130                 135                 140                 


Ile Gln Leu Val Gln Ser Gly Pro Asp Leu Lys Lys Pro Gly Glu Thr 
145                 150                 155                 160 


Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Phe Gly 
                165                 170                 175     


Met Asn Trp Val Lys Gln Ala Pro Gly Lys Gly Phe Lys Trp Met Ala 
            180                 185                 190         


Trp Ile Asn Thr Thr Arg Tyr Thr Gly Glu Ser Tyr Phe Ala Asp Asp 
        195                 200                 205             


Phe Lys Gly Arg Phe Ala Phe Ser Val Glu Thr Ser Ala Thr Thr Ala 
    210                 215                 220                 


Tyr Leu Gln Ile Asn Asn Leu Lys Thr Glu Asp Thr Ala Thr Tyr Phe 
225                 230                 235                 240 


Cys Ala Arg Gly Glu Ile Tyr Tyr Gly Tyr Asp Gly Gly Phe Ala Tyr 
                245                 250                 255     


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ala Thr Thr Thr Pro Ala 
            260                 265                 270         


Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser 
        275                 280                 285             


Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr 
    290                 295                 300                 


Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala 
305                 310                 315                 320 


Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys 
                325                 330                 335     


Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met 
            340                 345                 350         


Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe 
        355                 360                 365             


Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg 
    370                 375                 380                 


Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn 
385                 390                 395                 400 


Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg 
                405                 410                 415     


Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Gln Arg Arg Lys Asn 
            420                 425                 430         


Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu 
        435                 440                 445             


Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly 
    450                 455                 460                 


His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr 
465                 470                 475                 480 


Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg Gly Ser Gly Ala Thr 
                485                 490                 495     


Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly 
            500                 505                 510         


Pro Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu 
        515                 520                 525             


Leu His Ala Ala Arg Pro Asp Ile Gln Met Thr Gln Ser Pro Ser Ser 
    530                 535                 540                 


Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Lys Ala Ser 
545                 550                 555                 560 


Gln Asp Val Gly Ile Ala Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys 
                565                 570                 575     


Val Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg His Thr Gly Val 
            580                 585                 590         


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
        595                 600                 605             


Ile Ser Ser Leu Gln Pro Glu Asp Val Ala Thr Tyr Tyr Cys Gln Gln 
    610                 615                 620                 


Tyr Ser Ser Tyr Pro Tyr Thr Phe Gly Gln Gly Thr Lys Val Glu Ile 
625                 630                 635                 640 


Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
                645                 650                 655     


Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
            660                 665                 670         


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asp Phe Ser Arg Tyr 
        675                 680                 685             


Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
    690                 695                 700                 


Gly Glu Ile Asn Pro Asp Ser Ser Thr Ile Asn Tyr Ala Pro Ser Leu 
705                 710                 715                 720 


Lys Asp Lys Phe Ile Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
                725                 730                 735     


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
            740                 745                 750         


Ala Arg Pro Asp Gly Asn Tyr Trp Tyr Phe Asp Val Trp Gly Gln Gly 
        755                 760                 765             


Thr Leu Val Thr Val Ser Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro 
    770                 775                 780                 


Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu 
785                 790                 795                 800 


Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp 
                805                 810                 815     


Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly 
            820                 825                 830         


Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg 
        835                 840                 845             


Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln 
    850                 855                 860                 


Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu 
865                 870                 875                 880 


Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala 
                885                 890                 895     


Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu 
            900                 905                 910         


Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp 
        915                 920                 925             


Pro Glu Met Gly Gly Lys Pro Gln Arg Arg Lys Asn Pro Gln Glu Gly 
    930                 935                 940                 


Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu 
945                 950                 955                 960 


Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu 
                965                 970                 975     


Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His 
            980                 985                 990         


Met Gln Ala Leu Pro Pro Arg Gly  Ser Gly Glu Gly Arg  Gly Ser Leu 
        995                 1000                 1005             


Leu Thr  Cys Gly Asp Val Glu  Glu Asn Pro Gly Pro  Met Tyr Arg 
    1010                 1015                 1020             


Met Gln  Leu Leu Ser Cys Ile  Ala Leu Ser Leu Ala  Leu Val Thr 
    1025                 1030                 1035             


Asn Ser  Gly Ile His Val Phe  Ile Leu Gly Cys Phe  Ser Ala Gly 
    1040                 1045                 1050             


Leu Pro  Lys Thr Glu Ala Asn  Trp Val Asn Val Ile  Ser Asp Leu 
    1055                 1060                 1065             


Lys Lys  Ile Glu Asp Leu Ile  Gln Ser Met His Ile  Asp Ala Thr 
    1070                 1075                 1080             


Leu Tyr  Thr Glu Ser Asp Val  His Pro Ser Cys Lys  Val Thr Ala 
    1085                 1090                 1095             


Met Lys  Cys Phe Leu Leu Glu  Leu Gln Val Ile Ser  Leu Glu Ser 
    1100                 1105                 1110             


Gly Asp  Ala Ser Ile His Asp  Thr Val Glu Asn Leu  Ile Ile Leu 
    1115                 1120                 1125             


Ala Asn  Asn Ser Leu Ser Ser  Asn Gly Asn Val Thr  Glu Ser Gly 
    1130                 1135                 1140             


Cys Lys  Glu Cys Glu Glu Leu  Glu Glu Lys Asn Ile  Lys Glu Phe 
    1145                 1150                 1155             


Leu Gln  Ser Phe Val His Ile  Val Gln Met Phe Ile  Asn Thr Ser 
    1160                 1165                 1170             


Ser Gly  Gly Gly Ser Gly Gly  Gly Gly Ser Gly Gly  Gly Gly Ser 
    1175                 1180                 1185             


Gly Gly  Gly Gly Ser Gly Gly  Gly Ser Leu Gln Ala  Pro Arg Arg 
    1190                 1195                 1200             


Ala Arg  Gly Cys Arg Thr Leu  Gly Leu Pro Ala Leu  Leu Leu Leu 
    1205                 1210                 1215             


Leu Leu  Leu Arg Pro Pro Ala  Thr Arg Gly Ile Thr  Cys Pro Pro 
    1220                 1225                 1230             


Pro Met  Ser Val Glu His Ala  Asp Ile Trp Val Lys  Ser Tyr Ser 
    1235                 1240                 1245             


Leu Tyr  Ser Arg Glu Arg Tyr  Ile Cys Asn Ser Gly  Phe Lys Arg 
    1250                 1255                 1260             


Lys Ala  Gly Thr Ser Ser Leu  Thr Glu Cys Val Leu  Asn Lys Ala 
    1265                 1270                 1275             


Thr Asn  Val Ala His Trp Thr  Thr Pro Ser Leu Lys  Cys Ile Arg 
    1280                 1285                 1290             


<210>  206
<211>  3879
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  (BCMA-CS1-BB-IL-15/IL-15sushi, CD269-CS1-BB-IL-15/IL-15sushi CAR 
       nucleotide sequence)

<400>  206
agtgaccgcc ttgctcctgc cgctggcctt gctgctccac gccgccaggc cggatgtggt       60

gatgacccag agccatcgct ttatgagcac cagcgtgggc gaccgagtga gcattacctg      120

ccgcgcgagc caggatgtga acaccgcggt gagctggtat cagcagaaac cgggccagag      180

cccgaaactg ctgattttta gcgcgagcta tcgctatacc ggcgtgccgg atcgctttac      240

cggcagcggc agcggcgcgg attttaccct gaccattagc agcgtgcagg cggaagatct      300

ggcggtgtat tattgccagc agcattatag caccccgtgg acctttggcg gcggcaccaa      360

actggacatt aaaggagggg ggggatccgg gggaggaggc tccggcggag gcggaagcca      420

gattcagctg gtgcagagcg gcccggatct gaaaaaaccg ggcgaaaccg tgaaactgag      480

ctgcaaagcg agcggctata cctttaccaa ctttggcatg aactgggtga aacaggcgcc      540

gggcaaaggc tttaaatgga tggcgtggat taacaccacc cgctataccg gcgaaagcta      600

ttttgcggat gattttaaag gccgctttgc gtttagcgtg gaaaccagcg cgaccaccgc      660

gtatctgcag attaacaacc tgaaaaccga agataccgcg acctattttt gcgcgcgcgg      720

cgaaatttat tatggctatg atggcggctt tgcgtattgg ggccagggca ccctggtgac      780

cgtgagcgcg accacgacgc cagcgccgcg accaccaaca ccggcgccca ccatcgcgtc      840

gcagcccctg tccctgcgcc cagaggcgtg ccggccagcg gcggggggcg cagtgcacac      900

gagggggctg gacttcgcct gtgatatcta catctgggcg cccttggccg ggacttgtgg      960

ggtccttctc ctgtcactgg ttatcaccct ttactgcaaa cggggcagaa agaaactcct     1020

gtatatattc aaacaaccat ttatgagacc agtacaaact actcaagagg aagatggctg     1080

tagctgccga tttccagaag aagaagaagg aggatgtgaa ctgagagtga agttcagcag     1140

gagcgcagac gcccccgcgt accagcaggg ccagaaccag ctctataacg agctcaatct     1200

aggacgaaga gaggagtacg atgttttgga caagagacgt ggccgggacc ctgagatggg     1260

gggaaagccg cagagaagga agaaccctca ggaaggcctg tacaatgaac tgcagaaaga     1320

taagatggcg gaggcctaca gtgagattgg gatgaaaggc gagcgccgga ggggcaaggg     1380

gcacgatggc ctttaccagg gtctcagtac agccaccaag gacacctacg acgcccttca     1440

catgcaggcc ctgccccctc gcggaagcgg agccaccaac ttcagcctgc tgaagcaggc     1500

cggcgacgtg gaggagaacc ccggccccat ggccctgccc gtgaccgccc tgctgctgcc     1560

cctggccctg ctgctgcacg ccgccaggcc cgatattcag atgacccaga gcccgagcag     1620

cctgagcgcg agcgtgggcg accgggtgac cattacctgc aaagcgagcc aggatgtggg     1680

cattgcggtg gcgtggtatc agcagaaacc gggcaaagtg ccgaaactgc tgatttattg     1740

ggcgagcacc cgccataccg gcgtgccgga tcgctttagc ggcagcggca gcggcaccga     1800

ttttaccctg accattagca gcctgcagcc ggaagatgtg gcgacctatt attgccagca     1860

gtatagcagc tatccgtata cctttggcca gggcaccaaa gtggaaatta aaggaggggg     1920

gggatccggg ggaggaggct ccggcggagg cggaagcgaa gtgcagctgg tggaaagcgg     1980

cggcggcctg gtgcagccgg gcggcagcct gcgcctgagc tgcgcggcga gcggctttga     2040

ttttagccgc tattggatga gctgggtgcg ccaggcgccg ggcaaaggcc tggaatggat     2100

tggcgaaatt aacccggata gcagcaccat taactatgcg ccgagcctga aagataaatt     2160

tattattagc cgcgataacg cgaaaaacag cctgtatctg cagatgaaca gcctgcgcgc     2220

ggaagatacc gcggtgtatt attgcgcgcg cccggatggc aactattggt attttgatgt     2280

gtggggccag ggcaccctgg tgaccgtgag cagcaccacc acccccgccc ccaggccccc     2340

cacccccgcc cccaccatcg ccagccagcc cctgagcctg aggcccgagg cctgcaggcc     2400

cgccgccggc ggcgccgtgc acaccagggg cctggacttc gcctgcgaca tctacatctg     2460

ggcccccctg gccggcacct gcggcgtgct gctgctgagc ctggtgatca ccctgtactg     2520

caagaggggc aggaagaagc tgctgtacat cttcaagcag cccttcatga ggcccgtgca     2580

gaccacccag gaggaggacg gctgcagctg caggttcccc gaggaggagg agggcggctg     2640

cgagctgagg gtgaagttca gcaggagcgc cgacgccccc gcctaccagc agggccagaa     2700

ccagctgtac aacgagctga acctgggcag gagggaggag tacgacgtgc tggacaagag     2760

gaggggcagg gaccccgaga tgggcggcaa gccccagagg aggaagaacc cccaggaggg     2820

cctgtacaac gagctgcaga aggacaagat ggccgaggcc tacagcgaga tcggcatgaa     2880

gggcgagagg aggaggggca agggccacga cggcctgtac cagggcctga gcaccgccac     2940

caaggacacc tacgacgccc tgcacatgca ggccctgccc cccaggggca gcggcgaagg     3000

ccgcggcagc ctgctgacct gcggcgatgt ggaagaaaac ccgggcccca tgtacagaat     3060

gcagctgctg agctgcatcg ccctgagcct ggccctggtg accaacagcg gcatccacgt     3120

gttcatcctg ggctgcttca gcgccggcct gcccaagacc gaggccaact gggtgaacgt     3180

gatcagcgac ctgaagaaga tcgaggacct gatccagagc atgcacatcg acgccaccct     3240

gtacaccgag agcgacgtgc accccagctg caaggtgacc gccatgaagt gcttcctgct     3300

ggagctgcag gtgatcagcc tggagagcgg cgacgccagc atccacgaca ccgtggagaa     3360

cctgatcatc ctggccaaca acagcctgag cagcaacggc aacgtgaccg agagcggctg     3420

caaggagtgc gaggagctgg aggagaagaa catcaaggag ttcctgcaga gcttcgtgca     3480

catcgtgcag atgttcatca acaccagctc cggcggcggc tccggcggcg gcggctccgg     3540

cggcggcggc tccggcggcg gcggctccgg cggcggctcc ctgcaggccc ccagaagagc     3600

cagaggctgc agaaccctgg gcctgcccgc cctgctgctg ctgctgctgc tgagaccccc     3660

cgccaccaga ggcatcacct gccccccccc catgagcgtg gagcacgccg acatctgggt     3720

gaagagctac agcctgtaca gcagagagag atacatctgc aacagcggct tcaagagaaa     3780

ggccggcacc agcagcctga ccgagtgcgt gctgaacaag gccaccaacg tggcccactg     3840

gaccaccccc agcctgaagt gcatcagata agtttaaac                            3879


<210>  207
<211>  663
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  (BCMA-A7D-28-IL-15, CD269-A7D-28-IL-15 CAR amino acid sequence)

<400>  207

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Asp Val Val Met Thr Gln Ser His Arg Phe Met 
            20                  25                  30          


Ser Thr Ser Val Gly Asp Arg Val Ser Ile Thr Cys Arg Ala Ser Gln 
        35                  40                  45              


Asp Val Asn Thr Ala Val Ser Trp Tyr Gln Gln Lys Pro Gly Gln Ser 
    50                  55                  60                  


Pro Lys Leu Leu Ile Phe Ser Ala Ser Tyr Arg Tyr Thr Gly Val Pro 
65                  70                  75                  80  


Asp Arg Phe Thr Gly Ser Gly Ser Gly Ala Asp Phe Thr Leu Thr Ile 
                85                  90                  95      


Ser Ser Val Gln Ala Glu Asp Leu Ala Val Tyr Tyr Cys Gln Gln His 
            100                 105                 110         


Tyr Ser Thr Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Asp Ile Lys 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln 
    130                 135                 140                 


Ile Gln Leu Val Gln Ser Gly Pro Asp Leu Lys Lys Pro Gly Glu Thr 
145                 150                 155                 160 


Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Phe Gly 
                165                 170                 175     


Met Asn Trp Val Lys Gln Ala Pro Gly Lys Gly Phe Lys Trp Met Ala 
            180                 185                 190         


Trp Ile Asn Thr Tyr Thr Gly Glu Ser Tyr Phe Ala Asp Asp Phe Lys 
        195                 200                 205             


Gly Arg Phe Ala Phe Ser Val Glu Thr Ser Ala Thr Thr Ala Tyr Leu 
    210                 215                 220                 


Gln Ile Asn Asn Leu Lys Thr Glu Asp Thr Ala Thr Tyr Phe Cys Ala 
225                 230                 235                 240 


Arg Gly Glu Ile Tyr Tyr Gly Tyr Asp Gly Gly Phe Ala Tyr Trp Gly 
                245                 250                 255     


Gln Gly Thr Leu Val Thr Val Ser Ala Thr Thr Thr Pro Ala Pro Arg 
            260                 265                 270         


Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg 
        275                 280                 285             


Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly 
    290                 295                 300                 


Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr 
305                 310                 315                 320 


Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Arg Ser 
                325                 330                 335     


Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg 
            340                 345                 350         


Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg 
        355                 360                 365             


Asp Phe Ala Ala Tyr Arg Ser Arg Val Lys Phe Ser Arg Ser Ala Asp 
    370                 375                 380                 


Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn 
385                 390                 395                 400 


Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg 
                405                 410                 415     


Asp Pro Glu Met Gly Gly Lys Pro Gln Arg Arg Lys Asn Pro Gln Glu 
            420                 425                 430         


Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser 
        435                 440                 445             


Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly 
    450                 455                 460                 


Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu 
465                 470                 475                 480 


His Met Gln Ala Leu Pro Pro Arg Gly Ser Gly Ala Thr Asn Phe Ser 
                485                 490                 495     


Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met Tyr 
            500                 505                 510         


Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu Val Thr 
        515                 520                 525             


Asn Ser Gly Ile His Val Phe Ile Leu Gly Cys Phe Ser Ala Gly Leu 
    530                 535                 540                 


Pro Lys Thr Glu Ala Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys 
545                 550                 555                 560 


Ile Glu Asp Leu Ile Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr 
                565                 570                 575     


Glu Ser Asp Val His Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe 
            580                 585                 590         


Leu Leu Glu Leu Gln Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile 
        595                 600                 605             


His Asp Thr Val Glu Asn Leu Ile Ile Leu Ala Asn Asn Ser Leu Ser 
    610                 615                 620                 


Ser Asn Gly Asn Val Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu 
625                 630                 635                 640 


Glu Glu Lys Asn Ile Lys Glu Phe Leu Gln Ser Phe Val His Ile Val 
                645                 650                 655     


Gln Met Phe Ile Asn Thr Ser 
            660             


<210>  208
<211>  2000
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  (BCMA-A7D-28-IL-15, CD269-A7D-28-IL-15 CAR nucleotide sequence)

<400>  208
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccggacgtgg tgatgaccca gagccacagg ttcatgagca ccagcgtggg cgacagggtg      120

agcatcacct gcagggccag ccaggacgtg aacaccgccg tgagctggta ccagcagaag      180

cccggccaga gccccaagct gctgatcttc agcgccagct acaggtacac cggcgtgccc      240

gacaggttca ccggcagcgg cagcggcgcc gacttcaccc tgaccatcag cagcgtgcag      300

gccgaggacc tggccgtgta ctactgccag cagcactaca gcaccccctg gaccttcggc      360

ggcggcacca agctggacat caagggaggg gggggatccg ggggaggagg ctccggcgga      420

ggcggaagcc agatccagct ggtgcagagc ggccccgacc tgaagaagcc cggcgagacc      480

gtgaagctga gctgcaaggc cagcggctac accttcacca acttcggcat gaactgggtg      540

aagcaggccc ccggcaaggg cttcaagtgg atggcctgga tcaacaccta caccggcgag      600

agctacttcg ccgacgactt caagggcagg ttcgccttca gcgtggagac cagcgccacc      660

accgcctacc tgcagatcaa caacctgaag accgaggaca ccgccaccta cttctgcgcc      720

aggggcgaga tctactacgg ctacgacggc ggcttcgcct actggggcca gggcaccctg      780

gtgaccgtga gcgccaccac gacgccagcg ccgcgaccac caacaccggc gcccaccatc      840

gcgtcgcagc ccctgtccct gcgcccagag gcgtgccggc cagcggcggg gggcgcagtg      900

cacacgaggg ggctggactt cgcctgtgat atctacatct gggcgccctt ggccgggact      960

tgtggggtcc ttctcctgtc actggttatc accctttact gcaggagtaa gaggagcagg     1020

ctcctgcaca gtgactacat gaacatgact ccccgccgcc ccgggcccac ccgcaagcat     1080

taccagccct atgccccacc acgcgacttc gcagcctatc gctccagagt gaagttcagc     1140

aggagcgcag acgcccccgc gtaccagcag ggccagaacc agctctataa cgagctcaat     1200

ctaggacgaa gagaggagta cgatgttttg gacaagagac gtggccggga ccctgagatg     1260

gggggaaagc cgcagagaag gaagaaccct caggaaggcc tgtacaatga actgcagaaa     1320

gataagatgg cggaggccta cagtgagatt gggatgaaag gcgagcgccg gaggggcaag     1380

gggcacgatg gcctttacca gggtctcagt acagccacca aggacaccta cgacgccctt     1440

cacatgcagg ccctgccccc tcgcggaagc ggagccacca acttcagcct gctgaagcag     1500

gccggcgacg tggaggagaa ccccggcccc atgtacagaa tgcagctgct gagctgcatc     1560

gccctgagcc tggccctggt gaccaacagc ggcatccacg tgttcatcct gggctgcttc     1620

agcgccggcc tgcccaagac cgaggccaac tgggtgaacg tgatcagcga cctgaagaag     1680

atcgaggacc tgatccagag catgcacatc gacgccaccc tgtacaccga gagcgacgtg     1740

caccccagct gcaaggtgac cgccatgaag tgcttcctgc tggagctgca ggtgatcagc     1800

ctggagagcg gcgacgccag catccacgac accgtggaga acctgatcat cctggccaac     1860

aacagcctga gcagcaacgg caacgtgacc gagagcggct gcaaggagtg cgaggagctg     1920

gaggagaaga acatcaagga gttcctgcag agcttcgtgc acatcgtgca gatgttcatc     1980

aacaccagct aagtttaaac                                                 2000


<210>  209
<211>  672
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  (CD33b-28-IL-15 CAR amino acid sequence)

<400>  209

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Met Ala Asp Tyr Lys Asp Ile Val Met Thr Gln 
            20                  25                  30          


Ser His Lys Phe Leu Leu Val Ser Val Gly Asp Arg Val Ser Ile Thr 
        35                  40                  45              


Cys Lys Ala Ser Gln Asp Val Ser Thr Ala Val Ala Trp Tyr Gln Gln 
    50                  55                  60                  


Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile Tyr Ser Ala Ser Tyr Arg 
65                  70                  75                  80  


Tyr Thr Gly Val Pro Asp Arg Phe Ile Gly Ser Gly Ser Gly Thr Asp 
                85                  90                  95      


Phe Thr Leu Thr Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Asp Tyr 
            100                 105                 110         


Phe Cys Gln Gln His Tyr Ser Thr Pro Leu Thr Phe Gly Ala Gly Thr 
        115                 120                 125             


Lys Leu Glu Ile Lys Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Ser Gly Gly Gly Ser Glu Val Gln Leu Lys Glu 
145                 150                 155                 160 


Ser Gly Pro Gly Leu Val Ala Pro Ser Gln Ser Leu Ser Ile Thr Cys 
                165                 170                 175     


Thr Val Ser Gly Phe Pro Leu Thr Ser Tyr Gly Val Ser Trp Val Arg 
            180                 185                 190         


Gln Pro Pro Gly Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Gly Asp 
        195                 200                 205             


Gly Ser Thr Asn Tyr His Ser Ala Leu Ile Ser Arg Leu Ser Ile Ser 
    210                 215                 220                 


Lys Asp Asn Ser Lys Ser Gln Val Phe Leu Lys Leu Asn Asn Leu Gln 
225                 230                 235                 240 


Thr Asp Asp Thr Ala Thr Tyr Tyr Cys Ala Arg Asp Thr Tyr Tyr Pro 
                245                 250                 255     


Tyr Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser 
            260                 265                 270         


Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile 
        275                 280                 285             


Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala 
    290                 295                 300                 


Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr 
305                 310                 315                 320 


Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu 
                325                 330                 335     


Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile 
            340                 345                 350         


Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp 
        355                 360                 365             


Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
    370                 375                 380                 


Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly 
385                 390                 395                 400 


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
                405                 410                 415     


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
            420                 425                 430         


Pro Gln Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln 
        435                 440                 445             


Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu 
    450                 455                 460                 


Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr 
465                 470                 475                 480 


Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro 
                485                 490                 495     


Arg Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp 
            500                 505                 510         


Val Glu Glu Asn Pro Gly Pro Met Tyr Arg Met Gln Leu Leu Ser Cys 
        515                 520                 525             


Ile Ala Leu Ser Leu Ala Leu Val Thr Asn Ser Gly Ile His Val Phe 
    530                 535                 540                 


Ile Leu Gly Cys Phe Ser Ala Gly Leu Pro Lys Thr Glu Ala Asn Trp 
545                 550                 555                 560 


Val Asn Val Ile Ser Asp Leu Lys Lys Ile Glu Asp Leu Ile Gln Ser 
                565                 570                 575     


Met His Ile Asp Ala Thr Leu Tyr Thr Glu Ser Asp Val His Pro Ser 
            580                 585                 590         


Cys Lys Val Thr Ala Met Lys Cys Phe Leu Leu Glu Leu Gln Val Ile 
        595                 600                 605             


Ser Leu Glu Ser Gly Asp Ala Ser Ile His Asp Thr Val Glu Asn Leu 
    610                 615                 620                 


Ile Ile Leu Ala Asn Asn Ser Leu Ser Ser Asn Gly Asn Val Thr Glu 
625                 630                 635                 640 


Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu Lys Asn Ile Lys Glu 
                645                 650                 655     


Phe Leu Gln Ser Phe Val His Ile Val Gln Met Phe Ile Asn Thr Ser 
            660                 665                 670         


<210>  210
<211>  2027
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  (CD33b-28-IL-15 , CD33b-BB-IL15xp-2G CAR nucleotide sequence)

<400>  210
atggccctgc ccgtgaccgc cctgctgctg cccctggccc tgctgctgca cgccgccagg       60

cccatggccg actacaagga catcgtgatg acccagagcc acaagttcct gctggtgagc      120

gtgggcgaca gggtgagcat cacctgcaag gccagccagg acgtgagcac cgccgtggcc      180

tggtaccagc agaagcccgg ccagagcccc aagctgctga tctacagcgc cagctacagg      240

tacaccggcg tgcccgacag gttcatcggc agcggcagcg gcaccgactt caccctgacc      300

atcagcagcg tgcaggccga ggacctggcc gactacttct gccagcagca ctacagcacc      360

cccctgacct tcggcgccgg caccaagctg gagatcaaga ggggcggcgg cggcagcggc      420

ggcggcggca gcggcggcgg cggcagcagc ggcggcggca gcgaggtgca gctgaaggag      480

agcggccccg gcctggtggc ccccagccag agcctgagca tcacctgcac cgtgagcggc      540

ttccccctga ccagctacgg cgtgagctgg gtgaggcagc cccccggcaa gggcctggag      600

tggctgggcg tgatctgggg cgacggcagc accaactacc acagcgccct gatcagcagg      660

ctgagcatca gcaaggacaa cagcaagagc caggtgttcc tgaagctgaa caacctgcag      720

accgacgaca ccgccaccta ctactgcgcc agggacacct actaccccta ctacgccatg      780

gactactggg gccagggcac cagcgtgacc gtgagcagca ccaccacccc cgcccccagg      840

ccccccaccc ccgcccccac catcgccagc cagcccctga gcctgaggcc cgaggcctgc      900

aggcccgccg ccggcggcgc cgtgcacacc aggggcctgg acttcgcctg cgacatctac      960

atctgggccc ccctggccgg cacctgcggc gtgctgctgc tgagcctggt gatcaccctg     1020

tactgcaaac ggggcagaaa gaaactcctg tatatattca aacaaccatt tatgagacca     1080

gtacaaacta ctcaagagga agatggctgt agctgccgat ttccagaaga agaagaagga     1140

ggatgtgaac tgagggtgaa gttcagcagg agcgccgacg cccccgccta ccagcagggc     1200

cagaaccagc tgtacaacga gctgaacctg ggcaggaggg aggagtacga cgtgctggac     1260

aagaggaggg gcagggaccc cgagatgggc ggcaagcccc agaggaggaa gaacccccag     1320

gagggcctgt acaacgagct gcagaaggac aagatggccg aggcctacag cgagatcggc     1380

atgaagggcg agaggaggag gggcaagggc cacgacggcc tgtaccaggg cctgagcacc     1440

gccaccaagg acacctacga cgccctgcac atgcaggccc tgccccccag gggaagcgga     1500

gccaccaact tcagcctgct gaagcaggcc ggcgacgtgg aggagaaccc cggccccatg     1560

tacagaatgc agctgctgag ctgcatcgcc ctgagcctgg ccctggtgac caacagcggc     1620

atccacgtgt tcatcctggg ctgcttcagc gccggcctgc ccaagaccga ggccaactgg     1680

gtgaacgtga tcagcgacct gaagaagatc gaggacctga tccagagcat gcacatcgac     1740

gccaccctgt acaccgagag cgacgtgcac cccagctgca aggtgaccgc catgaagtgc     1800

ttcctgctgg agctgcaggt gatcagcctg gagagcggcg acgccagcat ccacgacacc     1860

gtggagaacc tgatcatcct ggccaacaac agcctgagca gcaacggcaa cgtgaccgag     1920

agcggctgca aggagtgcga ggagctggag gagaagaaca tcaaggagtt cctgcagagc     1980

ttcgtgcaca tcgtgcagat gttcatcaac accagctaag tttaaac                   2027


<210>  211
<211>  669
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  (CD19bb-BB-IL-15 CAR amino acid sequence)

<400>  211

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu 
            20                  25                  30          


Ile Lys Pro Gly Ala Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr 
        35                  40                  45              


Thr Phe Thr Ser Tyr Val Met His Trp Val Lys Gln Lys Pro Gly Gln 
    50                  55                  60                  


Gly Leu Glu Trp Ile Gly Tyr Ile Asn Pro Tyr Asn Asp Gly Thr Lys 
65                  70                  75                  80  


Tyr Asn Glu Lys Phe Lys Gly Lys Ala Thr Leu Thr Ser Asp Lys Ser 
                85                  90                  95      


Ser Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Thr Ser Glu Asp Ser 
            100                 105                 110         


Ala Val Tyr Tyr Cys Ala Arg Gly Thr Tyr Tyr Tyr Gly Ser Arg Val 
        115                 120                 125             


Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val 
145                 150                 155                 160 


Met Thr Gln Ala Ala Pro Ser Ile Pro Val Thr Pro Gly Glu Ser Val 
                165                 170                 175     


Ser Ile Ser Cys Arg Ser Ser Lys Ser Leu Leu Asn Ser Asn Gly Asn 
            180                 185                 190         


Thr Tyr Leu Tyr Trp Phe Leu Gln Arg Pro Gly Gln Ser Pro Gln Leu 
        195                 200                 205             


Leu Ile Tyr Arg Met Ser Asn Leu Ala Ser Gly Val Pro Asp Arg Phe 
    210                 215                 220                 


Ser Gly Ser Gly Ser Gly Thr Ala Phe Thr Leu Arg Ile Ser Arg Val 
225                 230                 235                 240 


Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln His Leu Glu Tyr 
                245                 250                 255     


Pro Phe Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Arg Thr Thr 
            260                 265                 270         


Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln 
        275                 280                 285             


Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala 
    290                 295                 300                 


Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala 
305                 310                 315                 320 


Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr 
                325                 330                 335     


Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln 
            340                 345                 350         


Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser 
        355                 360                 365             


Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys 
    370                 375                 380                 


Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln 
385                 390                 395                 400 


Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu 
                405                 410                 415     


Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Gln Arg 
            420                 425                 430         


Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys 
        435                 440                 445             


Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg 
    450                 455                 460                 


Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys 
465                 470                 475                 480 


Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg Gly Ser 
                485                 490                 495     


Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu 
            500                 505                 510         


Asn Pro Gly Pro Met Tyr Arg Met Gln Leu Leu Ser Cys Ile Ala Leu 
        515                 520                 525             


Ser Leu Ala Leu Val Thr Asn Ser Gly Ile His Val Phe Ile Leu Gly 
    530                 535                 540                 


Cys Phe Ser Ala Gly Leu Pro Lys Thr Glu Ala Asn Trp Val Asn Val 
545                 550                 555                 560 


Ile Ser Asp Leu Lys Lys Ile Glu Asp Leu Ile Gln Ser Met His Ile 
                565                 570                 575     


Asp Ala Thr Leu Tyr Thr Glu Ser Asp Val His Pro Ser Cys Lys Val 
            580                 585                 590         


Thr Ala Met Lys Cys Phe Leu Leu Glu Leu Gln Val Ile Ser Leu Glu 
        595                 600                 605             


Ser Gly Asp Ala Ser Ile His Asp Thr Val Glu Asn Leu Ile Ile Leu 
    610                 615                 620                 


Ala Asn Asn Ser Leu Ser Ser Asn Gly Asn Val Thr Glu Ser Gly Cys 
625                 630                 635                 640 


Lys Glu Cys Glu Glu Leu Glu Glu Lys Asn Ile Lys Glu Phe Leu Gln 
                645                 650                 655     


Ser Phe Val His Ile Val Gln Met Phe Ile Asn Thr Ser 
            660                 665                 


<210>  212
<211>  2018
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  (CD19b-BB-IL-15 CAR nucleotide sequence)

<400>  212
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccggaggtcc agctgcagca gtctggacct gagctgataa agcctggggc ttcagtgaag      120

atgtcctgca aggcttctgg atacacattc actagctatg ttatgcactg ggtgaagcag      180

aagcctgggc agggccttga gtggattgga tatattaatc cttacaatga tggtactaag      240

tacaatgaga agttcaaagg caaggccaca ctgacttcag acaaatcctc cagcacagcc      300

tacatggagc tcagcagcct gacctctgag gactctgcgg tctattactg tgcaagaggg      360

acttattact acggtagtag ggtatttgac tactggggcc aaggcaccac tctcacagtc      420

tcctcaggtg gagggggctc aggcggaggt ggctctgggg gtggaggctc ggacattgtg      480

atgactcagg ctgcaccctc tatacctgtc actcctggag agtcagtatc catctcctgc      540

aggtctagta agagtctcct gaatagtaat ggcaacactt acttgtattg gttcctgcag      600

aggccaggcc agtctcctca gctcctgata tatcggatgt ccaaccttgc ctcaggagtc      660

ccagacaggt tcagtggcag tgggtcagga actgctttca cactgagaat cagtagagtg      720

gaggctgagg atgtgggtgt ttattactgt atgcaacatc tagaatatcc gttcacgttc      780

ggtgctggga ccaagctgga gctgaaacgg accacgacgc cagcgccgcg accaccaaca      840

ccggcgccca ccatcgcgtc gcagcccctg tccctgcgcc cagaggcgtg ccggccagcg      900

gcggggggcg cagtgcacac gagggggctg gacttcgcct gtgatatcta catctgggcg      960

cccttggccg ggacttgtgg ggtccttctc ctgtcactgg ttatcaccct ttactgcaaa     1020

cggggcagaa agaaactcct gtatatattc aaacaaccat ttatgagacc agtacaaact     1080

actcaagagg aagatggctg tagctgccga tttccagaag aagaagaagg aggatgtgaa     1140

ctgagagtga agttcagcag gagcgcagac gcccccgcgt accagcaggg ccagaaccag     1200

ctctataacg agctcaatct aggacgaaga gaggagtacg atgttttgga caagagacgt     1260

ggccgggacc ctgagatggg gggaaagccg cagagaagga agaaccctca ggaaggcctg     1320

tacaatgaac tgcagaaaga taagatggcg gaggcctaca gtgagattgg gatgaaaggc     1380

gagcgccgga ggggcaaggg gcacgatggc ctttaccagg gtctcagtac agccaccaag     1440

gacacctacg acgcccttca catgcaggcc ctgccccctc gcggaagcgg agccaccaac     1500

ttcagcctgc tgaagcaggc cggcgacgtg gaggagaacc ccggccccat gtacagaatg     1560

cagctgctga gctgcatcgc cctgagcctg gccctggtga ccaacagcgg catccacgtg     1620

ttcatcctgg gctgcttcag cgccggcctg cccaagaccg aggccaactg ggtgaacgtg     1680

atcagcgacc tgaagaagat cgaggacctg atccagagca tgcacatcga cgccaccctg     1740

tacaccgaga gcgacgtgca ccccagctgc aaggtgaccg ccatgaagtg cttcctgctg     1800

gagctgcagg tgatcagcct ggagagcggc gacgccagca tccacgacac cgtggagaac     1860

ctgatcatcc tggccaacaa cagcctgagc agcaacggca acgtgaccga gagcggctgc     1920

aaggagtgcg aggagctgga ggagaagaac atcaaggagt tcctgcagag cttcgtgcac     1980

atcgtgcaga tgttcatcaa caccagctaa gtttaaac                             2018


<210>  213
<211>  821
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  (CD269-A7D-28-IL-15/IL-15sushi anchor CAR nucleotide sequence)

<400>  213

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Asp Val Val Met Thr Gln Ser His Arg Phe Met 
            20                  25                  30          


Ser Thr Ser Val Gly Asp Arg Val Ser Ile Thr Cys Arg Ala Ser Gln 
        35                  40                  45              


Asp Val Asn Thr Ala Val Ser Trp Tyr Gln Gln Lys Pro Gly Gln Ser 
    50                  55                  60                  


Pro Lys Leu Leu Ile Phe Ser Ala Ser Tyr Arg Tyr Thr Gly Val Pro 
65                  70                  75                  80  


Asp Arg Phe Thr Gly Ser Gly Ser Gly Ala Asp Phe Thr Leu Thr Ile 
                85                  90                  95      


Ser Ser Val Gln Ala Glu Asp Leu Ala Val Tyr Tyr Cys Gln Gln His 
            100                 105                 110         


Tyr Ser Thr Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Asp Ile Lys 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln 
    130                 135                 140                 


Ile Gln Leu Val Gln Ser Gly Pro Asp Leu Lys Lys Pro Gly Glu Thr 
145                 150                 155                 160 


Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Phe Gly 
                165                 170                 175     


Met Asn Trp Val Lys Gln Ala Pro Gly Lys Gly Phe Lys Trp Met Ala 
            180                 185                 190         


Trp Ile Asn Thr Tyr Thr Gly Glu Ser Tyr Phe Ala Asp Asp Phe Lys 
        195                 200                 205             


Gly Arg Phe Ala Phe Ser Val Glu Thr Ser Ala Thr Thr Ala Tyr Leu 
    210                 215                 220                 


Gln Ile Asn Asn Leu Lys Thr Glu Asp Thr Ala Thr Tyr Phe Cys Ala 
225                 230                 235                 240 


Arg Gly Glu Ile Tyr Tyr Gly Tyr Asp Gly Gly Phe Ala Tyr Trp Gly 
                245                 250                 255     


Gln Gly Thr Leu Val Thr Val Ser Ala Thr Thr Thr Pro Ala Pro Arg 
            260                 265                 270         


Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg 
        275                 280                 285             


Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly 
    290                 295                 300                 


Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr 
305                 310                 315                 320 


Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Arg Ser 
                325                 330                 335     


Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg 
            340                 345                 350         


Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg 
        355                 360                 365             


Asp Phe Ala Ala Tyr Arg Ser Arg Val Lys Phe Ser Arg Ser Ala Asp 
    370                 375                 380                 


Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn 
385                 390                 395                 400 


Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg 
                405                 410                 415     


Asp Pro Glu Met Gly Gly Lys Pro Gln Arg Arg Lys Asn Pro Gln Glu 
            420                 425                 430         


Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser 
        435                 440                 445             


Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly 
    450                 455                 460                 


Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu 
465                 470                 475                 480 


His Met Gln Ala Leu Pro Pro Arg Gly Ser Gly Ala Thr Asn Phe Ser 
                485                 490                 495     


Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met Tyr 
            500                 505                 510         


Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu Val Thr 
        515                 520                 525             


Asn Ser Gly Ile His Val Phe Ile Leu Gly Cys Phe Ser Ala Gly Leu 
    530                 535                 540                 


Pro Lys Thr Glu Ala Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys 
545                 550                 555                 560 


Ile Glu Asp Leu Ile Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr 
                565                 570                 575     


Glu Ser Asp Val His Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe 
            580                 585                 590         


Leu Leu Glu Leu Gln Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile 
        595                 600                 605             


His Asp Thr Val Glu Asn Leu Ile Ile Leu Ala Asn Asn Ser Leu Ser 
    610                 615                 620                 


Ser Asn Gly Asn Val Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu 
625                 630                 635                 640 


Glu Glu Lys Asn Ile Lys Glu Phe Leu Gln Ser Phe Val His Ile Val 
                645                 650                 655     


Gln Met Phe Ile Asn Thr Ser Ser Gly Gly Gly Ser Gly Gly Gly Gly 
            660                 665                 670         


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Leu 
        675                 680                 685             


Gln Ile Thr Cys Pro Pro Pro Met Ser Val Glu His Ala Asp Ile Trp 
    690                 695                 700                 


Val Lys Ser Tyr Ser Leu Tyr Ser Arg Glu Arg Tyr Ile Cys Asn Ser 
705                 710                 715                 720 


Gly Phe Lys Arg Lys Ala Gly Thr Ser Ser Leu Thr Glu Cys Val Leu 
                725                 730                 735     


Asn Lys Ala Thr Asn Val Ala His Trp Thr Thr Pro Ser Leu Lys Cys 
            740                 745                 750         


Ile Arg Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr 
        755                 760                 765             


Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala 
    770                 775                 780                 


Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Val 
785                 790                 795                 800 


Ala Ile Ser Thr Ser Thr Val Leu Leu Cys Gly Leu Ser Ala Val Ser 
                805                 810                 815     


Leu Leu Ala Cys Tyr 
            820     


<210>  214
<211>  2466
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  (CD269-A7D-28-IL-15/IL-15sushi anchor CAR nucleotide sequence)

<400>  214
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccggacgtgg tgatgaccca gagccacagg ttcatgagca ccagcgtggg cgacagggtg      120

agcatcacct gcagggccag ccaggacgtg aacaccgccg tgagctggta ccagcagaag      180

cccggccaga gccccaagct gctgatcttc agcgccagct acaggtacac cggcgtgccc      240

gacaggttca ccggcagcgg cagcggcgcc gacttcaccc tgaccatcag cagcgtgcag      300

gccgaggacc tggccgtgta ctactgccag cagcactaca gcaccccctg gaccttcggc      360

ggcggcacca agctggacat caagggaggg gggggatccg ggggaggagg ctccggcgga      420

ggcggaagcc agatccagct ggtgcagagc ggccccgacc tgaagaagcc cggcgagacc      480

gtgaagctga gctgcaaggc cagcggctac accttcacca acttcggcat gaactgggtg      540

aagcaggccc ccggcaaggg cttcaagtgg atggcctgga tcaacaccta caccggcgag      600

agctacttcg ccgacgactt caagggcagg ttcgccttca gcgtggagac cagcgccacc      660

accgcctacc tgcagatcaa caacctgaag accgaggaca ccgccaccta cttctgcgcc      720

aggggcgaga tctactacgg ctacgacggc ggcttcgcct actggggcca gggcaccctg      780

gtgaccgtga gcgccaccac gacgccagcg ccgcgaccac caacaccggc gcccaccatc      840

gcgtcgcagc ccctgtccct gcgcccagag gcgtgccggc cagcggcggg gggcgcagtg      900

cacacgaggg ggctggactt cgcctgtgat atctacatct gggcgccctt ggccgggact      960

tgtggggtcc ttctcctgtc actggttatc accctttact gcaggagtaa gaggagcagg     1020

ctcctgcaca gtgactacat gaacatgact ccccgccgcc ccgggcccac ccgcaagcat     1080

taccagccct atgccccacc acgcgacttc gcagcctatc gctccagagt gaagttcagc     1140

aggagcgcag acgcccccgc gtaccagcag ggccagaacc agctctataa cgagctcaat     1200

ctaggacgaa gagaggagta cgatgttttg gacaagagac gtggccggga ccctgagatg     1260

gggggaaagc cgcagagaag gaagaaccct caggaaggcc tgtacaatga actgcagaaa     1320

gataagatgg cggaggccta cagtgagatt gggatgaaag gcgagcgccg gaggggcaag     1380

gggcacgatg gcctttacca gggtctcagt acagccacca aggacaccta cgacgccctt     1440

cacatgcagg ccctgccccc tcgcggaagc ggagccacca acttcagcct gctgaagcag     1500

gccggcgacg tggaggagaa ccccggcccc atgtacagaa tgcagctgct gagctgcatc     1560

gccctgagcc tggccctggt gaccaacagc ggcatccacg tgttcatcct gggctgcttc     1620

agcgccggcc tgcccaagac cgaggccaac tgggtgaacg tgatcagcga cctgaagaag     1680

atcgaggacc tgatccagag catgcacatc gacgccaccc tgtacaccga gagcgacgtg     1740

caccccagct gcaaggtgac cgccatgaag tgcttcctgc tggagctgca ggtgatcagc     1800

ctggagagcg gcgacgccag catccacgac accgtggaga acctgatcat cctggccaac     1860

aacagcctga gcagcaacgg caacgtgacc gagagcggct gcaaggagtg cgaggagctg     1920

gaggagaaga acatcaagga gttcctgcag agcttcgtgc acatcgtgca gatgttcatc     1980

aacaccagct ccggcggcgg ctccggcggc ggcggctccg gcggcggcgg ctccggcggc     2040

ggcggctccg gcggcggctc cctgcagatc acctgccccc cccccatgag cgtggagcac     2100

gccgacatct gggtgaagag ctacagcctg tacagcagag agagatacat ctgcaacagc     2160

ggcttcaaga gaaaggccgg caccagcagc ctgaccgagt gcgtgctgaa caaggccacc     2220

aacgtggccc actggaccac ccccagcctg aagtgcatca gaaccaccac ccccgccccc     2280

aggcccccca cccccgcccc caccatcgcc agccagcccc tgagcctgag gcccgaggcc     2340

tgcaggcccg ccgccggcgg cgccgtgcac accaggggcc tggacttcgc ctgcgacgtg     2400

gctatctcca cgtccactgt cctgctgtgt gggctgagcg ctgtgtctct cctggcatgc     2460

tactaa                                                                2466


<210>  215
<211>  785
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  (CD269-A7D-28-IL-15/IL-15sushi-2G CAR amino acid sequence)

<400>  215

Asp Arg Thr Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala 
1               5                   10                  15      


Leu Leu Leu His Ala Ala Arg Pro Asp Val Val Met Thr Gln Ser His 
            20                  25                  30          


Arg Phe Met Ser Thr Ser Val Gly Asp Arg Val Ser Ile Thr Cys Arg 
        35                  40                  45              


Ala Ser Gln Asp Val Asn Thr Ala Val Ser Trp Tyr Gln Gln Lys Pro 
    50                  55                  60                  


Gly Gln Ser Pro Lys Leu Leu Ile Phe Ser Ala Ser Tyr Arg Tyr Thr 
65                  70                  75                  80  


Gly Val Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Ala Asp Phe Thr 
                85                  90                  95      


Leu Thr Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Val Tyr Tyr Cys 
            100                 105                 110         


Gln Gln His Tyr Ser Thr Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu 
        115                 120                 125             


Asp Ile Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gln Ile Gln Leu Val Gln Ser Gly Pro Asp Leu Lys Lys Pro 
145                 150                 155                 160 


Gly Glu Thr Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr 
                165                 170                 175     


Asn Phe Gly Met Asn Trp Val Lys Gln Ala Pro Gly Lys Gly Phe Lys 
            180                 185                 190         


Trp Met Ala Trp Ile Asn Thr Tyr Thr Gly Glu Ser Tyr Phe Ala Asp 
        195                 200                 205             


Asp Phe Lys Gly Arg Phe Ala Phe Ser Val Glu Thr Ser Ala Thr Thr 
    210                 215                 220                 


Ala Tyr Leu Gln Ile Asn Asn Leu Lys Thr Glu Asp Thr Ala Thr Tyr 
225                 230                 235                 240 


Phe Cys Ala Arg Gly Glu Ile Tyr Tyr Gly Tyr Asp Gly Gly Phe Ala 
                245                 250                 255     


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ala Thr Thr Thr Pro 
            260                 265                 270         


Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu 
        275                 280                 285             


Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His 
    290                 295                 300                 


Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu 
305                 310                 315                 320 


Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr 
                325                 330                 335     


Cys Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met 
            340                 345                 350         


Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala 
        355                 360                 365             


Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Arg Val Lys Phe Ser Arg 
    370                 375                 380                 


Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn 
385                 390                 395                 400 


Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg 
                405                 410                 415     


Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Gln Arg Arg Lys Asn 
            420                 425                 430         


Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu 
        435                 440                 445             


Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly 
    450                 455                 460                 


His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr 
465                 470                 475                 480 


Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg Gly Ser Gly Glu Gly 
                485                 490                 495     


Arg Gly Ser Leu Leu Thr Cys Gly Asp Val Glu Glu Asn Pro Gly Pro 
            500                 505                 510         


Met Tyr Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu 
        515                 520                 525             


Val Thr Asn Ser Gly Ile His Val Phe Ile Leu Gly Cys Phe Ser Ala 
    530                 535                 540                 


Gly Leu Pro Lys Thr Glu Ala Asn Trp Val Asn Val Ile Ser Asp Leu 
545                 550                 555                 560 


Lys Lys Ile Glu Asp Leu Ile Gln Ser Met His Ile Asp Ala Thr Leu 
                565                 570                 575     


Tyr Thr Glu Ser Asp Val His Pro Ser Cys Lys Val Thr Ala Met Lys 
            580                 585                 590         


Cys Phe Leu Leu Glu Leu Gln Val Ile Ser Leu Glu Ser Gly Asp Ala 
        595                 600                 605             


Ser Ile His Asp Thr Val Glu Asn Leu Ile Ile Leu Ala Asn Asn Ser 
    610                 615                 620                 


Leu Ser Ser Asn Gly Asn Val Thr Glu Ser Gly Cys Lys Glu Cys Glu 
625                 630                 635                 640 


Glu Leu Glu Glu Lys Asn Ile Lys Glu Phe Leu Gln Ser Phe Val His 
                645                 650                 655     


Ile Val Gln Met Phe Ile Asn Thr Ser Ser Gly Gly Gly Ser Gly Gly 
            660                 665                 670         


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        675                 680                 685             


Ser Leu Gln Ala Pro Arg Arg Ala Arg Gly Cys Arg Thr Leu Gly Leu 
    690                 695                 700                 


Pro Ala Leu Leu Leu Leu Leu Leu Leu Arg Pro Pro Ala Thr Arg Gly 
705                 710                 715                 720 


Ile Thr Cys Pro Pro Pro Met Ser Val Glu His Ala Asp Ile Trp Val 
                725                 730                 735     


Lys Ser Tyr Ser Leu Tyr Ser Arg Glu Arg Tyr Ile Cys Asn Ser Gly 
            740                 745                 750         


Phe Lys Arg Lys Ala Gly Thr Ser Ser Leu Thr Glu Cys Val Leu Asn 
        755                 760                 765             


Lys Ala Thr Asn Val Ala His Trp Thr Thr Pro Ser Leu Lys Cys Ile 
    770                 775                 780                 


Arg 
785 


<210>  216
<211>  2357
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  (CD269-A7D-28-IL-15/IL-15sushi-2G CAR nucleotide sequence)

<400>  216
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccggacgtgg tgatgaccca gagccacagg ttcatgagca ccagcgtggg cgacagggtg      120

agcatcacct gcagggccag ccaggacgtg aacaccgccg tgagctggta ccagcagaag      180

cccggccaga gccccaagct gctgatcttc agcgccagct acaggtacac cggcgtgccc      240

gacaggttca ccggcagcgg cagcggcgcc gacttcaccc tgaccatcag cagcgtgcag      300

gccgaggacc tggccgtgta ctactgccag cagcactaca gcaccccctg gaccttcggc      360

ggcggcacca agctggacat caagggaggg gggggatccg ggggaggagg ctccggcgga      420

ggcggaagcc agatccagct ggtgcagagc ggccccgacc tgaagaagcc cggcgagacc      480

gtgaagctga gctgcaaggc cagcggctac accttcacca acttcggcat gaactgggtg      540

aagcaggccc ccggcaaggg cttcaagtgg atggcctgga tcaacaccta caccggcgag      600

agctacttcg ccgacgactt caagggcagg ttcgccttca gcgtggagac cagcgccacc      660

accgcctacc tgcagatcaa caacctgaag accgaggaca ccgccaccta cttctgcgcc      720

aggggcgaga tctactacgg ctacgacggc ggcttcgcct actggggcca gggcaccctg      780

gtgaccgtga gcgccaccac gacgccagcg ccgcgaccac caacaccggc gcccaccatc      840

gcgtcgcagc ccctgtccct gcgcccagag gcgtgccggc cagcggcggg gggcgcagtg      900

cacacgaggg ggctggactt cgcctgtgat atctacatct gggcgccctt ggccgggact      960

tgtggggtcc ttctcctgtc actggttatc accctttact gcaggagtaa gaggagcagg     1020

ctcctgcaca gtgactacat gaacatgact ccccgccgcc ccgggcccac ccgcaagcat     1080

taccagccct atgccccacc acgcgacttc gcagcctatc gctccagagt gaagttcagc     1140

aggagcgcag acgcccccgc gtaccagcag ggccagaacc agctctataa cgagctcaat     1200

ctaggacgaa gagaggagta cgatgttttg gacaagagac gtggccggga ccctgagatg     1260

gggggaaagc cgcagagaag gaagaaccct caggaaggcc tgtacaatga actgcagaaa     1320

gataagatgg cggaggccta cagtgagatt gggatgaaag gcgagcgccg gaggggcaag     1380

gggcacgatg gcctttacca gggtctcagt acagccacca aggacaccta cgacgccctt     1440

cacatgcagg ccctgccccc tcgcggcagc ggcgaaggcc gcggcagcct gctgacctgc     1500

ggcgatgtgg aagaaaaccc gggccccatg tacagaatgc agctgctgag ctgcatcgcc     1560

ctgagcctgg ccctggtgac caacagcggc atccacgtgt tcatcctggg ctgcttcagc     1620

gccggcctgc ccaagaccga ggccaactgg gtgaacgtga tcagcgacct gaagaagatc     1680

gaggacctga tccagagcat gcacatcgac gccaccctgt acaccgagag cgacgtgcac     1740

cccagctgca aggtgaccgc catgaagtgc ttcctgctgg agctgcaggt gatcagcctg     1800

gagagcggcg acgccagcat ccacgacacc gtggagaacc tgatcatcct ggccaacaac     1860

agcctgagca gcaacggcaa cgtgaccgag agcggctgca aggagtgcga ggagctggag     1920

gagaagaaca tcaaggagtt cctgcagagc ttcgtgcaca tcgtgcagat gttcatcaac     1980

accagctccg gcggcggctc cggcggcggc ggctccggcg gcggcggctc cggcggcggc     2040

ggctccggcg gcggctccct gcaggccccc agaagagcca gaggctgcag aaccctgggc     2100

ctgcccgccc tgctgctgct gctgctgctg agaccccccg ccaccagagg catcacctgc     2160

ccccccccca tgagcgtgga gcacgccgac atctgggtga agagctacag cctgtacagc     2220

agagagagat acatctgcaa cagcggcttc aagagaaagg ccggcaccag cagcctgacc     2280

gagtgcgtgc tgaacaaggc caccaacgtg gcccactgga ccacccccag cctgaagtgc     2340

atcagataag tttaaac                                                    2357


<210>  217
<211>  486
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  (GD2-3F8-BB-2G CAR amino acid sequence)

<400>  217

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gln Val Gln Leu Lys Glu Ser Gly Pro Gly Leu 
            20                  25                  30          


Val Ala Pro Ser Gln Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe 
        35                  40                  45              


Ser Val Thr Asn Tyr Gly Val His Trp Val Arg Gln Pro Pro Gly Lys 
    50                  55                  60                  


Gly Leu Glu Trp Leu Gly Val Ile Trp Ala Gly Gly Ile Thr Asn Tyr 
65                  70                  75                  80  


Asn Ser Ala Phe Met Ser Arg Leu Ser Ile Ser Lys Asp Asn Ser Lys 
                85                  90                  95      


Ser Gln Val Phe Leu Lys Met Asn Ser Leu Gln Ile Asp Asp Thr Ala 
            100                 105                 110         


Met Tyr Tyr Cys Ala Ser Arg Gly Gly His Tyr Gly Tyr Ala Leu Asp 
        115                 120                 125             


Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser Ile Val Met Thr 
145                 150                 155                 160 


Gln Thr Pro Lys Phe Leu Leu Val Ser Ala Gly Asp Arg Val Thr Ile 
                165                 170                 175     


Thr Cys Lys Ala Ser Gln Ser Val Ser Asn Asp Val Thr Trp Tyr Gln 
            180                 185                 190         


Gln Lys Ala Gly Gln Ser Pro Lys Leu Leu Ile Tyr Ser Ala Ser Asn 
        195                 200                 205             


Arg Tyr Ser Gly Val Pro Asp Arg Phe Thr Gly Ser Gly Tyr Gly Thr 
    210                 215                 220                 


Ala Phe Thr Phe Thr Ile Ser Thr Val Gln Ala Glu Asp Leu Ala Val 
225                 230                 235                 240 


Tyr Phe Cys Gln Gln Asp Tyr Ser Ser Phe Gly Gly Gly Thr Lys Leu 
                245                 250                 255     


Glu Ile Lys Arg Thr Val Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr 
            260                 265                 270         


Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala 
        275                 280                 285             


Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe 
    290                 295                 300                 


Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val 
305                 310                 315                 320 


Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys 
                325                 330                 335     


Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr 
            340                 345                 350         


Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu 
        355                 360                 365             


Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro 
    370                 375                 380                 


Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly 
385                 390                 395                 400 


Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro 
                405                 410                 415     


Glu Met Gly Gly Lys Pro Gln Arg Arg Lys Asn Pro Gln Glu Gly Leu 
            420                 425                 430         


Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile 
        435                 440                 445             


Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr 
    450                 455                 460                 


Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met 
465                 470                 475                 480 


Gln Ala Leu Pro Pro Arg 
                485     


<210>  218
<211>  1480
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  (GD2-3F8-BB-2G CAR nucleotide sequence)

<400>  218
gcgatcgcac catggccctg cccgtgaccg ccctgctgct gcccctggcc ctgctgctgc       60

acgccgccag gccccaggtg cagctgaagg agagcggccc cggcctggtg gcccccagcc      120

agagcctgag catcacctgc accgtgagcg gcttcagcgt gaccaactac ggcgtgcact      180

gggtgaggca gccccccggc aagggcctgg agtggctggg cgtgatctgg gccggcggca      240

tcaccaacta caacagcgcc ttcatgagca ggctgagcat cagcaaggac aacagcaaga      300

gccaggtgtt cctgaagatg aacagcctgc agatcgacga caccgccatg tactactgcg      360

ccagcagggg cggccactac ggctacgccc tggactactg gggccagggc accagcgtga      420

ccgtgagcag cggagggggg ggatccgggg gaggaggctc cggcggaggc ggaagcagca      480

tcgtgatgac ccagaccccc aagttcctgc tggtgagcgc cggcgacagg gtgaccatca      540

cctgcaaggc cagccagagc gtgagcaacg acgtgacctg gtaccagcag aaggccggcc      600

agagccccaa gctgctgatc tacagcgcca gcaacaggta cagcggcgtg cccgacaggt      660

tcaccggcag cggctacggc accgccttca ccttcaccat cagcaccgtg caggccgagg      720

acctggccgt gtacttctgc cagcaggact acagcagctt cggcggcggc accaagctgg      780

agatcaagag gaccgtgacc accacccccg cccccaggcc ccccaccccc gcccccacca      840

tcgccagcca gcccctgagc ctgaggcccg aggcctgcag gcccgccgcc ggcggcgccg      900

tgcacaccag gggcctggac ttcgcctgcg acatctacat ctgggccccc ctggccggca      960

cctgcggcgt gctgctgctg agcctggtga tcaccctgta ctgcaaacgg ggcagaaaga     1020

aactcctgta tatattcaaa caaccattta tgagaccagt acaaactact caagaggaag     1080

atggctgtag ctgccgattt ccagaagaag aagaaggagg atgtgaactg agggtgaagt     1140

tcagcaggag cgccgacgcc cccgcctacc agcagggcca gaaccagctg tacaacgagc     1200

tgaacctggg caggagggag gagtacgacg tgctggacaa gaggaggggc agggaccccg     1260

agatgggcgg caagccccag aggaggaaga acccccagga gggcctgtac aacgagctgc     1320

agaaggacaa gatggccgag gcctacagcg agatcggcat gaagggcgag aggaggaggg     1380

gcaagggcca cgacggcctg taccagggcc tgagcaccgc caccaaggac acctacgacg     1440

ccctgcacat gcaggccctg ccccccaggt aagtttaaac                           1480


<210>  219
<211>  483
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  (GD2-3G6-BB-2G CAR amino acid sequence)

<400>  219

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Ser Ile Val Met Thr Gln Thr Pro Lys Phe Leu 
            20                  25                  30          


Leu Val Ser Ala Gly Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln 
        35                  40                  45              


Ser Val Ser Asn Asp Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser 
    50                  55                  60                  


Pro Lys Leu Leu Ile Tyr Ser Ala Ser Asn Arg Tyr Thr Gly Val Pro 
65                  70                  75                  80  


Asp Arg Phe Thr Gly Ser Gly Tyr Gly Thr Asp Phe Thr Phe Thr Ile 
                85                  90                  95      


Ser Thr Val Gln Ala Glu Asp Leu Ala Val Tyr Phe Cys Gln Gln Asp 
            100                 105                 110         


Tyr Ser Ser Leu Gly Gly Gly Thr Lys Leu Glu Ile Lys Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Val 
    130                 135                 140                 


Lys Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln Ser Leu Ser Ile 
145                 150                 155                 160 


Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asn Tyr Gly Val His Trp 
                165                 170                 175     


Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Leu Gly Val Ile Trp 
            180                 185                 190         


Ala Gly Gly Ser Thr Asn Tyr Asn Ser Ala Leu Met Ser Arg Leu Ser 
        195                 200                 205             


Ile Ser Lys Asp Asn Ser Lys Ser Gln Val Phe Leu Lys Met Asn Ser 
    210                 215                 220                 


Leu Gln Thr Asp Asp Thr Ala Met Tyr Tyr Cys Ala Ser Arg Gly Gly 
225                 230                 235                 240 


Asn Tyr Gly Tyr Ala Leu Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr 
                245                 250                 255     


Val Ser Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro 
            260                 265                 270         


Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro 
        275                 280                 285             


Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp 
    290                 295                 300                 


Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu 
305                 310                 315                 320 


Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu 
                325                 330                 335     


Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu 
            340                 345                 350         


Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys 
        355                 360                 365             


Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln 
    370                 375                 380                 


Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu 
385                 390                 395                 400 


Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly 
                405                 410                 415     


Gly Lys Pro Gln Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu 
            420                 425                 430         


Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys 
        435                 440                 445             


Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu 
    450                 455                 460                 


Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu 
465                 470                 475                 480 


Pro Pro Arg 
            


<210>  220
<211>  1471
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  (GD2-3G6-BB-2G CAR nucleotide sequence)

<400>  220
gcgatcgcac catggccctg cccgtgaccg ccctgctgct gcccctggcc ctgctgctgc       60

acgccgccag gcccagtatt gtgatgaccc agactcccaa attcctgctt gtatcagcag      120

gagacagggt taccataacc tgcaaggcca gtcagagtgt gagtaatgat gtggcttggt      180

accaacagaa gccagggcag tctccgaaac tgctgatata ctctgcatcc aatcgctaca      240

ctggagtccc tgatcgcttc actggcagtg gatatgggac ggatttcact ttcaccatca      300

gcactgtgca ggctgaagac ctggcagttt atttctgtca gcaggattat agctcgctcg      360

gaggggggac caagctggaa ataaaaggtg gaggcggttc aggcggaggt ggctctggcg      420

gtggcggatc gcaggtgcag gtgaaggagt caggacctgg cctggtggcg ccctcacaga      480

gcctgtccat cacttgcact gtctctgggt tttcattaac caattatggt gtacactggg      540

ttcgccagcc tccaggaaag ggtctggagt ggctgggagt aatatgggct ggtggaagca      600

caaattataa ttcggctctt atgtccagac tgagcatcag caaggacaac tccaagagcc      660

aagttttctt aaaaatgaac agtctgcaaa ctgatgacac agccatgtac tactgtgcca      720

gtcggggggg taactacggc tatgctttgg actactgggg tcaaggaacc tcagtcaccg      780

tctcctcaac caccaccccc gcccccaggc cccccacccc cgcccccacc atcgccagcc      840

agcccctgag cctgaggccc gaggcctgca ggcccgccgc cggcggcgcc gtgcacacca      900

ggggcctgga cttcgcctgc gacatctaca tctgggcccc cctggccggc acctgcggcg      960

tgctgctgct gagcctggtg atcaccctgt actgcaaacg gggcagaaag aaactcctgt     1020

atatattcaa acaaccattt atgagaccag tacaaactac tcaagaggaa gatggctgta     1080

gctgccgatt tccagaagaa gaagaaggag gatgtgaact gagggtgaag ttcagcagga     1140

gcgccgacgc ccccgcctac cagcagggcc agaaccagct gtacaacgag ctgaacctgg     1200

gcaggaggga ggagtacgac gtgctggaca agaggagggg cagggacccc gagatgggcg     1260

gcaagcccca gaggaggaag aacccccagg agggcctgta caacgagctg cagaaggaca     1320

agatggccga ggcctacagc gagatcggca tgaagggcga gaggaggagg ggcaagggcc     1380

acgacggcct gtaccagggc ctgagcaccg ccaccaagga cacctacgac gccctgcaca     1440

tgcaggccct gccccccagg taagtttaaa c                                    1471


<210>  221
<211>  488
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  (GD2-8H9-BB-2G CAR amino acid sequence)

<400>  221

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gln Val Lys Leu Gln Gln Ser Gly Ala Glu Leu 
            20                  25                  30          


Val Lys Pro Gly Ala Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr 
        35                  40                  45              


Thr Phe Thr Asn Tyr Asp Ile Asn Trp Val Arg Gln Arg Pro Glu Gln 
    50                  55                  60                  


Gly Leu Glu Trp Ile Gly Trp Ile Phe Pro Gly Asp Gly Ser Thr Gln 
65                  70                  75                  80  


Tyr Asn Glu Lys Phe Lys Gly Lys Ala Thr Leu Thr Thr Asp Thr Ser 
                85                  90                  95      


Ser Ser Thr Ala Tyr Met Gln Leu Ser Arg Leu Thr Ser Glu Asp Ser 
            100                 105                 110         


Ala Val Tyr Phe Cys Ala Arg Gln Thr Thr Ala Thr Trp Phe Ala Tyr 
        115                 120                 125             


Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Asp Gly Gly Gly Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Glu Leu Thr Gln 
145                 150                 155                 160 


Ser Pro Thr Thr Leu Ser Val Thr Pro Gly Asp Arg Val Ser Leu Ser 
                165                 170                 175     


Cys Arg Ala Ser Gln Ser Ile Ser Asp Tyr Leu His Trp Tyr Gln Gln 
            180                 185                 190         


Lys Ser His Glu Ser Pro Arg Leu Leu Ile Lys Tyr Ala Ser Gln Ser 
        195                 200                 205             


Ile Ser Gly Ile Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Ser Asp 
    210                 215                 220                 


Phe Thr Leu Ser Ile Asn Ser Val Glu Pro Glu Asp Val Gly Val Tyr 
225                 230                 235                 240 


Tyr Cys Gln Asn Gly His Ser Phe Pro Leu Thr Phe Gly Ala Gly Thr 
                245                 250                 255     


Lys Leu Glu Leu Lys Gln Ala Ala Thr Thr Thr Pro Ala Pro Arg Pro 
            260                 265                 270         


Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro 
        275                 280                 285             


Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu 
    290                 295                 300                 


Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys 
305                 310                 315                 320 


Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly 
                325                 330                 335     


Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val 
            340                 345                 350         


Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu 
        355                 360                 365             


Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp 
    370                 375                 380                 


Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn 
385                 390                 395                 400 


Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg 
                405                 410                 415     


Asp Pro Glu Met Gly Gly Lys Pro Gln Arg Arg Lys Asn Pro Gln Glu 
            420                 425                 430         


Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser 
        435                 440                 445             


Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly 
    450                 455                 460                 


Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu 
465                 470                 475                 480 


His Met Gln Ala Leu Pro Pro Arg 
                485             


<210>  222
<211>  1486
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  (GD2-8H9-BB-2G CAR nucleotide sequence)

<400>  222
gcgatcgcac catggccctg cccgtgaccg ccctgctgct gcccctggcc ctgctgctgc       60

acgccgccag gccccaggtc aaactgcagc agtctggggc tgaactggta aagcctgggg      120

cttcagtgaa attgtcctgc aaggcttctg gctacacctt cacaaactat gatataaact      180

gggtgaggca gaggcctgaa cagggacttg agtggattgg atggatcttc cccggcgacg      240

gcagcaccca gtacaacgag aagttcaagg gcaaggccac cctgaccacc gacaccagca      300

gcagcaccgc ctacatgcag ctgagcaggc tgaccagcga ggactctgct gtctatttct      360

gtgcaagaca gactacggct acctggtttg cttactgggg ccaagggacc acggtcaccg      420

tctcctcaga tggaggcggt tcaggcggag gtggctctgg cggtggcgga tcggacatcg      480

agctcactca gtctccaacc accctgtctg tgactccagg agatagagtc tctctttcct      540

gcagggccag ccagagtatt agcgactact tacactggta ccaacaaaaa tcacatgagt      600

ctccaaggct tctcatcaaa tatgcttccc aatccatctc tgggatcccc tccaggttca      660

gtggcagtgg atcagggtca gatttcactc tcagtatcaa cagtgtggaa cctgaagatg      720

ttggagtgta ttactgtcaa aatggtcaca gctttccgct cacgttcggt gctgggacca      780

agctggagct gaaacaggcg gccaccacca cccccgcccc caggcccccc acccccgccc      840

ccaccatcgc cagccagccc ctgagcctga ggcccgaggc ctgcaggccc gccgccggcg      900

gcgccgtgca caccaggggc ctggacttcg cctgcgacat ctacatctgg gcccccctgg      960

ccggcacctg cggcgtgctg ctgctgagcc tggtgatcac cctgtactgc aaacggggca     1020

gaaagaaact cctgtatata ttcaaacaac catttatgag accagtacaa actactcaag     1080

aggaagatgg ctgtagctgc cgatttccag aagaagaaga aggaggatgt gaactgaggg     1140

tgaagttcag caggagcgcc gacgcccccg cctaccagca gggccagaac cagctgtaca     1200

acgagctgaa cctgggcagg agggaggagt acgacgtgct ggacaagagg aggggcaggg     1260

accccgagat gggcggcaag ccccagagga ggaagaaccc ccaggagggc ctgtacaacg     1320

agctgcagaa ggacaagatg gccgaggcct acagcgagat cggcatgaag ggcgagagga     1380

ggaggggcaa gggccacgac ggcctgtacc agggcctgag caccgccacc aaggacacct     1440

acgacgccct gcacatgcag gccctgcccc ccaggtaagt ttaaac                    1486


<210>  223
<211>  486
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  (GD2-28-2G CAR amino acid sequence)

<400>  223

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu 
            20                  25                  30          


Ser Val Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ser Ser Gln 
        35                  40                  45              


Ser Leu Val His Arg Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln 
    50                  55                  60                  


Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile His Lys Val Ser Asn Arg 
65                  70                  75                  80  


Phe Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp 
                85                  90                  95      


Phe Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr 
            100                 105                 110         


Phe Cys Ser Gln Ser Thr His Val Pro Pro Leu Thr Phe Gly Ala Gly 
        115                 120                 125             


Thr Lys Leu Glu Leu Lys Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Leu Gln Ser Gly Pro Glu 
145                 150                 155                 160 


Leu Glu Lys Pro Gly Ala Ser Val Met Ile Ser Cys Lys Ala Ser Gly 
                165                 170                 175     


Ser Ser Phe Thr Gly Tyr Asn Met Asn Trp Val Arg Gln Asn Ile Gly 
            180                 185                 190         


Lys Ser Leu Glu Trp Ile Gly Ala Ile Asp Pro Tyr Tyr Gly Gly Thr 
        195                 200                 205             


Ser Tyr Asn Gln Lys Phe Lys Gly Arg Ala Thr Leu Thr Val Asp Lys 
    210                 215                 220                 


Ser Ser Ser Thr Ala Tyr Met His Leu Lys Ser Leu Thr Ser Glu Asp 
225                 230                 235                 240 


Ser Ala Val Tyr Tyr Cys Val Ser Gly Met Glu Tyr Trp Gly Gln Gly 
                245                 250                 255     


Thr Ser Val Thr Val Ser Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro 
            260                 265                 270         


Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu 
        275                 280                 285             


Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp 
    290                 295                 300                 


Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly 
305                 310                 315                 320 


Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Arg Ser Lys Arg 
                325                 330                 335     


Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro 
            340                 345                 350         


Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe 
        355                 360                 365             


Ala Ala Tyr Arg Ser Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro 
    370                 375                 380                 


Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly 
385                 390                 395                 400 


Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro 
                405                 410                 415     


Glu Met Gly Gly Lys Pro Gln Arg Arg Lys Asn Pro Gln Glu Gly Leu 
            420                 425                 430         


Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile 
        435                 440                 445             


Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr 
    450                 455                 460                 


Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met 
465                 470                 475                 480 


Gln Ala Leu Pro Pro Arg 
                485     


<210>  224
<211>  1480
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  (GD2-28-2G CAR nucleotide sequence)

<400>  224
gcgatcgcac catggcctta ccagtgaccg ccttgctcct gccgctggcc ttgctgctcc       60

acgccgccag gccggagatc gtgatgaccc agagccccgc caccctgagc gtgagccccg      120

gcgagagggc caccctgagc tgcaggagca gccagagcct ggtgcacagg aacggcaaca      180

cctacctgca ctggtacctg cagaagcccg gccagagccc caagctgctg atccacaagg      240

tgagcaacag gttcagcggc gtgcccgaca ggttcagcgg cagcggcagc ggcaccgact      300

tcaccctgaa gatcagcagg gtggaggccg aggacctggg cgtgtacttc tgcagccaga      360

gcacccacgt gccccccctg accttcggcg ccggcaccaa gctggagctg aagaggggcg      420

gcggcggcag cggcggcggc ggcagcggcg gcggcggcag cgaggtgcag ctgctgcaga      480

gcggccccga gctggagaag cccggcgcca gcgtgatgat cagctgcaag gccagcggca      540

gcagcttcac cggctacaac atgaactggg tgaggcagaa catcggcaag agcctggagt      600

ggatcggcgc catcgacccc tactacggcg gcaccagcta caaccagaag ttcaagggca      660

gggccaccct gaccgtggac aagagcagca gcaccgccta catgcacctg aagagcctga      720

ccagcgagga cagcgccgtg tactactgcg tgagcggcat ggagtactgg ggccagggca      780

ccagcgtgac cgtgagcagc accacgacgc cagcgccgcg accaccaaca ccggcgccca      840

ccatcgcgtc gcagcccctg tccctgcgcc cagaggcgtg ccggccagcg gcggggggcg      900

cagtgcacac gagggggctg gacttcgcct gtgatatcta catctgggcg cccttggccg      960

ggacttgtgg ggtccttctc ctgtcactgg ttatcaccct ttactgcagg agtaagagga     1020

gcaggctcct gcacagtgac tacatgaaca tgactccccg ccgccccggg cccacccgca     1080

agcattacca gccctatgcc ccaccacgcg acttcgcagc ctatcgctcc agagtgaagt     1140

tcagcaggag cgcagacgcc cccgcgtacc agcagggcca gaaccagctc tataacgagc     1200

tcaatctagg acgaagagag gagtacgatg ttttggacaa gagacgtggc cgggaccctg     1260

agatgggggg aaagccgcag agaaggaaga accctcagga aggcctgtac aatgaactgc     1320

agaaagataa gatggcggag gcctacagtg agattgggat gaaaggcgag cgccggaggg     1380

gcaaggggca cgatggcctt taccagggtc tcagtacagc caccaaggac acctacgacg     1440

cccttcacat gcaggccctg ccccctcgct aagtttaaac                           1480


<210>  225
<211>  1057
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  (GD2-28-2G-41BBL-IL15/IL-15sushi CAR amino acid sequence)

<400>  225

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu 
            20                  25                  30          


Ser Val Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ser Ser Gln 
        35                  40                  45              


Ser Leu Val His Arg Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln 
    50                  55                  60                  


Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile His Lys Val Ser Asn Arg 
65                  70                  75                  80  


Phe Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp 
                85                  90                  95      


Phe Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr 
            100                 105                 110         


Phe Cys Ser Gln Ser Thr His Val Pro Pro Leu Thr Phe Gly Ala Gly 
        115                 120                 125             


Thr Lys Leu Glu Leu Lys Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Leu Gln Ser Gly Pro Glu 
145                 150                 155                 160 


Leu Glu Lys Pro Gly Ala Ser Val Met Ile Ser Cys Lys Ala Ser Gly 
                165                 170                 175     


Ser Ser Phe Thr Gly Tyr Asn Met Asn Trp Val Arg Gln Asn Ile Gly 
            180                 185                 190         


Lys Ser Leu Glu Trp Ile Gly Ala Ile Asp Pro Tyr Tyr Gly Gly Thr 
        195                 200                 205             


Ser Tyr Asn Gln Lys Phe Lys Gly Arg Ala Thr Leu Thr Val Asp Lys 
    210                 215                 220                 


Ser Ser Ser Thr Ala Tyr Met His Leu Lys Ser Leu Thr Ser Glu Asp 
225                 230                 235                 240 


Ser Ala Val Tyr Tyr Cys Val Ser Gly Met Glu Tyr Trp Gly Gln Gly 
                245                 250                 255     


Thr Ser Val Thr Val Ser Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro 
            260                 265                 270         


Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu 
        275                 280                 285             


Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp 
    290                 295                 300                 


Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly 
305                 310                 315                 320 


Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Arg Ser Lys Arg 
                325                 330                 335     


Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro 
            340                 345                 350         


Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe 
        355                 360                 365             


Ala Ala Tyr Arg Ser Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro 
    370                 375                 380                 


Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly 
385                 390                 395                 400 


Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro 
                405                 410                 415     


Glu Met Gly Gly Lys Pro Gln Arg Arg Lys Asn Pro Gln Glu Gly Leu 
            420                 425                 430         


Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile 
        435                 440                 445             


Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr 
    450                 455                 460                 


Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met 
465                 470                 475                 480 


Gln Ala Leu Pro Pro Arg Gly Ser Gly Glu Gly Arg Gly Ser Leu Leu 
                485                 490                 495     


Thr Cys Gly Asp Val Glu Glu Asn Pro Gly Pro Met Glu Tyr Ala Ser 
            500                 505                 510         


Asp Ala Ser Leu Asp Pro Glu Ala Pro Trp Pro Pro Ala Pro Arg Ala 
        515                 520                 525             


Arg Ala Cys Arg Val Leu Pro Trp Ala Leu Val Ala Gly Leu Leu Leu 
    530                 535                 540                 


Leu Leu Leu Leu Ala Ala Ala Cys Ala Val Phe Leu Ala Cys Pro Trp 
545                 550                 555                 560 


Ala Val Ser Gly Ala Arg Ala Ser Pro Gly Ser Ala Ala Ser Pro Arg 
                565                 570                 575     


Leu Arg Glu Gly Pro Glu Leu Ser Pro Asp Asp Pro Ala Gly Leu Leu 
            580                 585                 590         


Asp Leu Arg Gln Gly Met Phe Ala Gln Leu Val Ala Gln Asn Val Leu 
        595                 600                 605             


Leu Ile Asp Gly Pro Leu Ser Trp Tyr Ser Asp Pro Gly Leu Ala Gly 
    610                 615                 620                 


Val Ser Leu Thr Gly Gly Leu Ser Tyr Lys Glu Asp Thr Lys Glu Leu 
625                 630                 635                 640 


Val Val Ala Lys Ala Gly Val Tyr Tyr Val Phe Phe Gln Leu Glu Leu 
                645                 650                 655     


Arg Arg Val Val Ala Gly Glu Gly Ser Gly Ser Val Ser Leu Ala Leu 
            660                 665                 670         


His Leu Gln Pro Leu Arg Ser Ala Ala Gly Ala Ala Ala Leu Ala Leu 
        675                 680                 685             


Thr Val Asp Leu Pro Pro Ala Ser Ser Glu Ala Arg Asn Ser Ala Phe 
    690                 695                 700                 


Gly Phe Gln Gly Arg Leu Leu His Leu Ser Ala Gly Gln Arg Leu Gly 
705                 710                 715                 720 


Val His Leu His Thr Glu Ala Arg Ala Arg His Ala Trp Gln Leu Thr 
                725                 730                 735     


Gln Gly Ala Thr Val Leu Gly Leu Phe Arg Val Thr Pro Glu Ile Pro 
            740                 745                 750         


Ala Gly Leu Pro Ser Pro Arg Ser Glu Gly Ser Gly Ala Thr Asn Phe 
        755                 760                 765             


Leu Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro 
    770                 775                 780                 


Met Tyr Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu 
785                 790                 795                 800 


Val Thr Asn Ser Gly Ile His Val Phe Ile Leu Gly Cys Phe Ser Ala 
                805                 810                 815     


Gly Leu Pro Lys Thr Glu Ala Asn Trp Val Asn Val Ile Ser Asp Leu 
            820                 825                 830         


Lys Lys Ile Glu Asp Leu Ile Gln Ser Met His Ile Asp Ala Thr Leu 
        835                 840                 845             


Tyr Thr Glu Ser Asp Val His Pro Ser Cys Lys Val Thr Ala Met Lys 
    850                 855                 860                 


Cys Phe Leu Leu Glu Leu Gln Val Ile Ser Leu Glu Ser Gly Asp Ala 
865                 870                 875                 880 


Ser Ile His Asp Thr Val Glu Asn Leu Ile Ile Leu Ala Asn Asn Ser 
                885                 890                 895     


Leu Ser Ser Asn Gly Asn Val Thr Glu Ser Gly Cys Lys Glu Cys Glu 
            900                 905                 910         


Glu Leu Glu Glu Lys Asn Ile Lys Glu Phe Leu Gln Ser Phe Val His 
        915                 920                 925             


Ile Val Gln Met Phe Ile Asn Thr Ser Ser Gly Gly Gly Ser Gly Gly 
    930                 935                 940                 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
945                 950                 955                 960 


Ser Leu Gln Ala Pro Arg Arg Ala Arg Gly Cys Arg Thr Leu Gly Leu 
                965                 970                 975     


Pro Ala Leu Leu Leu Leu Leu Leu Leu Arg Pro Pro Ala Thr Arg Gly 
            980                 985                 990         


Ile Thr Cys Pro Pro Pro Met Ser  Val Glu His Ala Asp  Ile Trp Val 
        995                 1000                 1005             


Lys Ser  Tyr Ser Leu Tyr Ser  Arg Glu Arg Tyr Ile  Cys Asn Ser 
    1010                 1015                 1020             


Gly Phe  Lys Arg Lys Ala Gly  Thr Ser Ser Leu Thr  Glu Cys Val 
    1025                 1030                 1035             


Leu Asn  Lys Ala Thr Asn Val  Ala His Trp Thr Thr  Pro Ser Leu 
    1040                 1045                 1050             


Lys Cys  Ile Arg 
    1055         


<210>  226
<211>  3193
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  (GD2-28-2G-41BBL-IL15/IL-15sushi CAR nucleotide sequence)

<400>  226
gcgatcgcac catggcctta ccagtgaccg ccttgctcct gccgctggcc ttgctgctcc       60

acgccgccag gccggagatc gtgatgaccc agagccccgc caccctgagc gtgagccccg      120

gcgagagggc caccctgagc tgcaggagca gccagagcct ggtgcacagg aacggcaaca      180

cctacctgca ctggtacctg cagaagcccg gccagagccc caagctgctg atccacaagg      240

tgagcaacag gttcagcggc gtgcccgaca ggttcagcgg cagcggcagc ggcaccgact      300

tcaccctgaa gatcagcagg gtggaggccg aggacctggg cgtgtacttc tgcagccaga      360

gcacccacgt gccccccctg accttcggcg ccggcaccaa gctggagctg aagaggggcg      420

gcggcggcag cggcggcggc ggcagcggcg gcggcggcag cgaggtgcag ctgctgcaga      480

gcggccccga gctggagaag cccggcgcca gcgtgatgat cagctgcaag gccagcggca      540

gcagcttcac cggctacaac atgaactggg tgaggcagaa catcggcaag agcctggagt      600

ggatcggcgc catcgacccc tactacggcg gcaccagcta caaccagaag ttcaagggca      660

gggccaccct gaccgtggac aagagcagca gcaccgccta catgcacctg aagagcctga      720

ccagcgagga cagcgccgtg tactactgcg tgagcggcat ggagtactgg ggccagggca      780

ccagcgtgac cgtgagcagc accacgacgc cagcgccgcg accaccaaca ccggcgccca      840

ccatcgcgtc gcagcccctg tccctgcgcc cagaggcgtg ccggccagcg gcggggggcg      900

cagtgcacac gagggggctg gacttcgcct gtgatatcta catctgggcg cccttggccg      960

ggacttgtgg ggtccttctc ctgtcactgg ttatcaccct ttactgcagg agtaagagga     1020

gcaggctcct gcacagtgac tacatgaaca tgactccccg ccgccccggg cccacccgca     1080

agcattacca gccctatgcc ccaccacgcg acttcgcagc ctatcgctcc agagtgaagt     1140

tcagcaggag cgcagacgcc cccgcgtacc agcagggcca gaaccagctc tataacgagc     1200

tcaatctagg acgaagagag gagtacgatg ttttggacaa gagacgtggc cgggaccctg     1260

agatgggggg aaagccgcag agaaggaaga accctcagga aggcctgtac aatgaactgc     1320

agaaagataa gatggcggag gcctacagtg agattgggat gaaaggcgag cgccggaggg     1380

gcaaggggca cgatggcctt taccagggtc tcagtacagc caccaaggac acctacgacg     1440

cccttcacat gcaggccctg ccccctcgcg gcagcggcga aggccgcggc agcctgctga     1500

cctgcggcga tgtggaagaa aacccgggcc ccatggaata cgcctctgac gcttcactgg     1560

accccgaagc cccgtggcct cccgcgcccc gcgctcgcgc ctgccgcgta ctgccttggg     1620

ccctggtcgc ggggctgctg ctgctgctgc tgctcgctgc cgcctgcgcc gtcttcctcg     1680

cctgcccctg ggccgtgtcc ggggctcgcg cctcgcccgg ctccgcggcc agcccgagac     1740

tccgcgaggg tcccgagctt tcgcccgacg atcccgccgg cctcttggac ctgcggcagg     1800

gcatgtttgc gcagctggtg gcccaaaatg ttctgctgat cgatgggccc ctgagctggt     1860

acagtgaccc aggcctggca ggcgtgtccc tgacgggggg cctgagctac aaagaggaca     1920

cgaaggagct ggtggtggcc aaggctggag tctactatgt cttctttcaa ctagagctgc     1980

ggcgcgtggt ggccggcgag ggctcaggct ccgtttcact tgcgctgcac ctgcagccac     2040

tgcgctctgc tgctggggcc gccgccctgg ctttgaccgt ggacctgcca cccgcctcct     2100

ccgaggctcg gaactcggcc ttcggtttcc agggccgctt gctgcacctg agtgccggcc     2160

agcgcctggg cgtccatctt cacactgagg ccagggcacg ccatgcctgg cagcttaccc     2220

agggcgccac agtcttggga ctcttccggg tgacccccga aatcccagcc ggactccctt     2280

caccgaggtc ggaaggaagc ggagctacta acttcttgag cctgctgaag caggctggag     2340

acgtggagga gaaccctgga cctatgtaca gaatgcagct gctgagctgc atcgccctga     2400

gcctggccct ggtgaccaac agcggcatcc acgtgttcat cctgggctgc ttcagcgccg     2460

gcctgcccaa gaccgaggcc aactgggtga acgtgatcag cgacctgaag aagatcgagg     2520

acctgatcca gagcatgcac atcgacgcca ccctgtacac cgagagcgac gtgcacccca     2580

gctgcaaggt gaccgccatg aagtgcttcc tgctggagct gcaggtgatc agcctggaga     2640

gcggcgacgc cagcatccac gacaccgtgg agaacctgat catcctggcc aacaacagcc     2700

tgagcagcaa cggcaacgtg accgagagcg gctgcaagga gtgcgaggag ctggaggaga     2760

agaacatcaa ggagttcctg cagagcttcg tgcacatcgt gcagatgttc atcaacacca     2820

gctccggcgg cggctccggc ggcggcggct ccggcggcgg cggctccggc ggcggcggct     2880

ccggcggcgg ctccctgcag gcccccagaa gagccagagg ctgcagaacc ctgggcctgc     2940

ccgccctgct gctgctgctg ctgctgagac cccccgccac cagaggcatc acctgccccc     3000

cccccatgag cgtggagcac gccgacatct gggtgaagag ctacagcctg tacagcagag     3060

agagatacat ctgcaacagc ggcttcaaga gaaaggccgg caccagcagc ctgaccgagt     3120

gcgtgctgaa caaggccacc aacgtggccc actggaccac ccccagcctg aagtgcatca     3180

gataagttta aac                                                        3193


<210>  227
<211>  661
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  (GD2-28-2G-IL15xp CAR amino acid sequence)

<400>  227

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu 
            20                  25                  30          


Ser Val Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ser Ser Gln 
        35                  40                  45              


Ser Leu Val His Arg Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln 
    50                  55                  60                  


Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile His Lys Val Ser Asn Arg 
65                  70                  75                  80  


Phe Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp 
                85                  90                  95      


Phe Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr 
            100                 105                 110         


Phe Cys Ser Gln Ser Thr His Val Pro Pro Leu Thr Phe Gly Ala Gly 
        115                 120                 125             


Thr Lys Leu Glu Leu Lys Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Leu Gln Ser Gly Pro Glu 
145                 150                 155                 160 


Leu Glu Lys Pro Gly Ala Ser Val Met Ile Ser Cys Lys Ala Ser Gly 
                165                 170                 175     


Ser Ser Phe Thr Gly Tyr Asn Met Asn Trp Val Arg Gln Asn Ile Gly 
            180                 185                 190         


Lys Ser Leu Glu Trp Ile Gly Ala Ile Asp Pro Tyr Tyr Gly Gly Thr 
        195                 200                 205             


Ser Tyr Asn Gln Lys Phe Lys Gly Arg Ala Thr Leu Thr Val Asp Lys 
    210                 215                 220                 


Ser Ser Ser Thr Ala Tyr Met His Leu Lys Ser Leu Thr Ser Glu Asp 
225                 230                 235                 240 


Ser Ala Val Tyr Tyr Cys Val Ser Gly Met Glu Tyr Trp Gly Gln Gly 
                245                 250                 255     


Thr Ser Val Thr Val Ser Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro 
            260                 265                 270         


Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu 
        275                 280                 285             


Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp 
    290                 295                 300                 


Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly 
305                 310                 315                 320 


Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Arg Ser Lys Arg 
                325                 330                 335     


Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro 
            340                 345                 350         


Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe 
        355                 360                 365             


Ala Ala Tyr Arg Ser Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro 
    370                 375                 380                 


Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly 
385                 390                 395                 400 


Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro 
                405                 410                 415     


Glu Met Gly Gly Lys Pro Gln Arg Arg Lys Asn Pro Gln Glu Gly Leu 
            420                 425                 430         


Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile 
        435                 440                 445             


Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr 
    450                 455                 460                 


Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met 
465                 470                 475                 480 


Gln Ala Leu Pro Pro Arg Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu 
                485                 490                 495     


Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met Tyr Arg Met 
            500                 505                 510         


Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu Val Thr Asn Ser 
        515                 520                 525             


Gly Ile His Val Phe Ile Leu Gly Cys Phe Ser Ala Gly Leu Pro Lys 
    530                 535                 540                 


Thr Glu Ala Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys Ile Glu 
545                 550                 555                 560 


Asp Leu Ile Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr Glu Ser 
                565                 570                 575     


Asp Val His Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe Leu Leu 
            580                 585                 590         


Glu Leu Gln Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile His Asp 
        595                 600                 605             


Thr Val Glu Asn Leu Ile Ile Leu Ala Asn Asn Ser Leu Ser Ser Asn 
    610                 615                 620                 


Gly Asn Val Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu 
625                 630                 635                 640 


Lys Asn Ile Lys Glu Phe Leu Gln Ser Phe Val His Ile Val Gln Met 
                645                 650                 655     


Phe Ile Asn Thr Ser 
            660     


<210>  228
<211>  2005
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  (GD2-28-2G-IL15xp CAR nucleotide sequence)

<400>  228
gcgatcgcac catggcctta ccagtgaccg ccttgctcct gccgctggcc ttgctgctcc       60

acgccgccag gccggagatc gtgatgaccc agagccccgc caccctgagc gtgagccccg      120

gcgagagggc caccctgagc tgcaggagca gccagagcct ggtgcacagg aacggcaaca      180

cctacctgca ctggtacctg cagaagcccg gccagagccc caagctgctg atccacaagg      240

tgagcaacag gttcagcggc gtgcccgaca ggttcagcgg cagcggcagc ggcaccgact      300

tcaccctgaa gatcagcagg gtggaggccg aggacctggg cgtgtacttc tgcagccaga      360

gcacccacgt gccccccctg accttcggcg ccggcaccaa gctggagctg aagaggggcg      420

gcggcggcag cggcggcggc ggcagcggcg gcggcggcag cgaggtgcag ctgctgcaga      480

gcggccccga gctggagaag cccggcgcca gcgtgatgat cagctgcaag gccagcggca      540

gcagcttcac cggctacaac atgaactggg tgaggcagaa catcggcaag agcctggagt      600

ggatcggcgc catcgacccc tactacggcg gcaccagcta caaccagaag ttcaagggca      660

gggccaccct gaccgtggac aagagcagca gcaccgccta catgcacctg aagagcctga      720

ccagcgagga cagcgccgtg tactactgcg tgagcggcat ggagtactgg ggccagggca      780

ccagcgtgac cgtgagcagc accacgacgc cagcgccgcg accaccaaca ccggcgccca      840

ccatcgcgtc gcagcccctg tccctgcgcc cagaggcgtg ccggccagcg gcggggggcg      900

cagtgcacac gagggggctg gacttcgcct gtgatatcta catctgggcg cccttggccg      960

ggacttgtgg ggtccttctc ctgtcactgg ttatcaccct ttactgcagg agtaagagga     1020

gcaggctcct gcacagtgac tacatgaaca tgactccccg ccgccccggg cccacccgca     1080

agcattacca gccctatgcc ccaccacgcg acttcgcagc ctatcgctcc agagtgaagt     1140

tcagcaggag cgcagacgcc cccgcgtacc agcagggcca gaaccagctc tataacgagc     1200

tcaatctagg acgaagagag gagtacgatg ttttggacaa gagacgtggc cgggaccctg     1260

agatgggggg aaagccgcag agaaggaaga accctcagga aggcctgtac aatgaactgc     1320

agaaagataa gatggcggag gcctacagtg agattgggat gaaaggcgag cgccggaggg     1380

gcaaggggca cgatggcctt taccagggtc tcagtacagc caccaaggac acctacgacg     1440

cccttcacat gcaggccctg ccccctcgcg gaagcggagc caccaacttc agcctgctga     1500

agcaggccgg cgacgtggag gagaaccccg gccccatgta cagaatgcag ctgctgagct     1560

gcatcgccct gagcctggcc ctggtgacca acagcggcat ccacgtgttc atcctgggct     1620

gcttcagcgc cggcctgccc aagaccgagg ccaactgggt gaacgtgatc agcgacctga     1680

agaagatcga ggacctgatc cagagcatgc acatcgacgc caccctgtac accgagagcg     1740

acgtgcaccc cagctgcaag gtgaccgcca tgaagtgctt cctgctggag ctgcaggtga     1800

tcagcctgga gagcggcgac gccagcatcc acgacaccgt ggagaacctg atcatcctgg     1860

ccaacaacag cctgagcagc aacggcaacg tgaccgagag cggctgcaag gagtgcgagg     1920

agctggagga gaagaacatc aaggagttcc tgcagagctt cgtgcacatc gtgcagatgt     1980

tcatcaacac cagctaagtt taaac                                           2005


<210>  229
<211>  761
<212>  PRT
<213>  Artificial Sequence

<220>
<223>   (GD2-28-41BBL CAR amino acid sequence)

<400>  229

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu 
            20                  25                  30          


Ser Val Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ser Ser Gln 
        35                  40                  45              


Ser Leu Val His Arg Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln 
    50                  55                  60                  


Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile His Lys Val Ser Asn Arg 
65                  70                  75                  80  


Phe Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp 
                85                  90                  95      


Phe Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr 
            100                 105                 110         


Phe Cys Ser Gln Ser Thr His Val Pro Pro Leu Thr Phe Gly Ala Gly 
        115                 120                 125             


Thr Lys Leu Glu Leu Lys Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Leu Gln Ser Gly Pro Glu 
145                 150                 155                 160 


Leu Glu Lys Pro Gly Ala Ser Val Met Ile Ser Cys Lys Ala Ser Gly 
                165                 170                 175     


Ser Ser Phe Thr Gly Tyr Asn Met Asn Trp Val Arg Gln Asn Ile Gly 
            180                 185                 190         


Lys Ser Leu Glu Trp Ile Gly Ala Ile Asp Pro Tyr Tyr Gly Gly Thr 
        195                 200                 205             


Ser Tyr Asn Gln Lys Phe Lys Gly Arg Ala Thr Leu Thr Val Asp Lys 
    210                 215                 220                 


Ser Ser Ser Thr Ala Tyr Met His Leu Lys Ser Leu Thr Ser Glu Asp 
225                 230                 235                 240 


Ser Ala Val Tyr Tyr Cys Val Ser Gly Met Glu Tyr Trp Gly Gln Gly 
                245                 250                 255     


Thr Ser Val Thr Val Ser Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro 
            260                 265                 270         


Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu 
        275                 280                 285             


Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp 
    290                 295                 300                 


Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly 
305                 310                 315                 320 


Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Arg Ser Lys Arg 
                325                 330                 335     


Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro 
            340                 345                 350         


Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe 
        355                 360                 365             


Ala Ala Tyr Arg Ser Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro 
    370                 375                 380                 


Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly 
385                 390                 395                 400 


Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro 
                405                 410                 415     


Glu Met Gly Gly Lys Pro Gln Arg Arg Lys Asn Pro Gln Glu Gly Leu 
            420                 425                 430         


Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile 
        435                 440                 445             


Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr 
    450                 455                 460                 


Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met 
465                 470                 475                 480 


Gln Ala Leu Pro Pro Arg Gly Ser Gly Glu Gly Arg Gly Ser Leu Leu 
                485                 490                 495     


Thr Cys Gly Asp Val Glu Glu Asn Pro Gly Pro Met Glu Tyr Ala Ser 
            500                 505                 510         


Asp Ala Ser Leu Asp Pro Glu Ala Pro Trp Pro Pro Ala Pro Arg Ala 
        515                 520                 525             


Arg Ala Cys Arg Val Leu Pro Trp Ala Leu Val Ala Gly Leu Leu Leu 
    530                 535                 540                 


Leu Leu Leu Leu Ala Ala Ala Cys Ala Val Phe Leu Ala Cys Pro Trp 
545                 550                 555                 560 


Ala Val Ser Gly Ala Arg Ala Ser Pro Gly Ser Ala Ala Ser Pro Arg 
                565                 570                 575     


Leu Arg Glu Gly Pro Glu Leu Ser Pro Asp Asp Pro Ala Gly Leu Leu 
            580                 585                 590         


Asp Leu Arg Gln Gly Met Phe Ala Gln Leu Val Ala Gln Asn Val Leu 
        595                 600                 605             


Leu Ile Asp Gly Pro Leu Ser Trp Tyr Ser Asp Pro Gly Leu Ala Gly 
    610                 615                 620                 


Val Ser Leu Thr Gly Gly Leu Ser Tyr Lys Glu Asp Thr Lys Glu Leu 
625                 630                 635                 640 


Val Val Ala Lys Ala Gly Val Tyr Tyr Val Phe Phe Gln Leu Glu Leu 
                645                 650                 655     


Arg Arg Val Val Ala Gly Glu Gly Ser Gly Ser Val Ser Leu Ala Leu 
            660                 665                 670         


His Leu Gln Pro Leu Arg Ser Ala Ala Gly Ala Ala Ala Leu Ala Leu 
        675                 680                 685             


Thr Val Asp Leu Pro Pro Ala Ser Ser Glu Ala Arg Asn Ser Ala Phe 
    690                 695                 700                 


Gly Phe Gln Gly Arg Leu Leu His Leu Ser Ala Gly Gln Arg Leu Gly 
705                 710                 715                 720 


Val His Leu His Thr Glu Ala Arg Ala Arg His Ala Trp Gln Leu Thr 
                725                 730                 735     


Gln Gly Ala Thr Val Leu Gly Leu Phe Arg Val Thr Pro Glu Ile Pro 
            740                 745                 750         


Ala Gly Leu Pro Ser Pro Arg Ser Glu 
        755                 760     


<210>  230
<211>  2305
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  (GD2-28-41BBL CAR nucleotide sequence)

<400>  230
gcgatcgcac catggcctta ccagtgaccg ccttgctcct gccgctggcc ttgctgctcc       60

acgccgccag gccggagatc gtgatgaccc agagccccgc caccctgagc gtgagccccg      120

gcgagagggc caccctgagc tgcaggagca gccagagcct ggtgcacagg aacggcaaca      180

cctacctgca ctggtacctg cagaagcccg gccagagccc caagctgctg atccacaagg      240

tgagcaacag gttcagcggc gtgcccgaca ggttcagcgg cagcggcagc ggcaccgact      300

tcaccctgaa gatcagcagg gtggaggccg aggacctggg cgtgtacttc tgcagccaga      360

gcacccacgt gccccccctg accttcggcg ccggcaccaa gctggagctg aagaggggcg      420

gcggcggcag cggcggcggc ggcagcggcg gcggcggcag cgaggtgcag ctgctgcaga      480

gcggccccga gctggagaag cccggcgcca gcgtgatgat cagctgcaag gccagcggca      540

gcagcttcac cggctacaac atgaactggg tgaggcagaa catcggcaag agcctggagt      600

ggatcggcgc catcgacccc tactacggcg gcaccagcta caaccagaag ttcaagggca      660

gggccaccct gaccgtggac aagagcagca gcaccgccta catgcacctg aagagcctga      720

ccagcgagga cagcgccgtg tactactgcg tgagcggcat ggagtactgg ggccagggca      780

ccagcgtgac cgtgagcagc accacgacgc cagcgccgcg accaccaaca ccggcgccca      840

ccatcgcgtc gcagcccctg tccctgcgcc cagaggcgtg ccggccagcg gcggggggcg      900

cagtgcacac gagggggctg gacttcgcct gtgatatcta catctgggcg cccttggccg      960

ggacttgtgg ggtccttctc ctgtcactgg ttatcaccct ttactgcagg agtaagagga     1020

gcaggctcct gcacagtgac tacatgaaca tgactccccg ccgccccggg cccacccgca     1080

agcattacca gccctatgcc ccaccacgcg acttcgcagc ctatcgctcc agagtgaagt     1140

tcagcaggag cgcagacgcc cccgcgtacc agcagggcca gaaccagctc tataacgagc     1200

tcaatctagg acgaagagag gagtacgatg ttttggacaa gagacgtggc cgggaccctg     1260

agatgggggg aaagccgcag agaaggaaga accctcagga aggcctgtac aatgaactgc     1320

agaaagataa gatggcggag gcctacagtg agattgggat gaaaggcgag cgccggaggg     1380

gcaaggggca cgatggcctt taccagggtc tcagtacagc caccaaggac acctacgacg     1440

cccttcacat gcaggccctg ccccctcgcg gcagcggcga aggccgcggc agcctgctga     1500

cctgcggcga tgtggaagaa aacccgggcc ccatggaata cgcctctgac gcttcactgg     1560

accccgaagc cccgtggcct cccgcgcccc gcgctcgcgc ctgccgcgta ctgccttggg     1620

ccctggtcgc ggggctgctg ctgctgctgc tgctcgctgc cgcctgcgcc gtcttcctcg     1680

cctgcccctg ggccgtgtcc ggggctcgcg cctcgcccgg ctccgcggcc agcccgagac     1740

tccgcgaggg tcccgagctt tcgcccgacg atcccgccgg cctcttggac ctgcggcagg     1800

gcatgtttgc gcagctggtg gcccaaaatg ttctgctgat cgatgggccc ctgagctggt     1860

acagtgaccc aggcctggca ggcgtgtccc tgacgggggg cctgagctac aaagaggaca     1920

cgaaggagct ggtggtggcc aaggctggag tctactatgt cttctttcaa ctagagctgc     1980

ggcgcgtggt ggccggcgag ggctcaggct ccgtttcact tgcgctgcac ctgcagccac     2040

tgcgctctgc tgctggggcc gccgccctgg ctttgaccgt ggacctgcca cccgcctcct     2100

ccgaggctcg gaactcggcc ttcggtttcc agggccgctt gctgcacctg agtgccggcc     2160

agcgcctggg cgtccatctt cacactgagg ccagggcacg ccatgcctgg cagcttaccc     2220

agggcgccac agtcttggga ctcttccggg tgacccccga aatcccagcc ggactccctt     2280

caccgaggtc ggaataagtt taaac                                           2305


<210>  231
<211>  819
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  (GD2-28-IL-15/IL-15sushi anchor CAR amino acid sequence)

<400>  231

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu 
            20                  25                  30          


Ser Val Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ser Ser Gln 
        35                  40                  45              


Ser Leu Val His Arg Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln 
    50                  55                  60                  


Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile His Lys Val Ser Asn Arg 
65                  70                  75                  80  


Phe Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp 
                85                  90                  95      


Phe Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr 
            100                 105                 110         


Phe Cys Ser Gln Ser Thr His Val Pro Pro Leu Thr Phe Gly Ala Gly 
        115                 120                 125             


Thr Lys Leu Glu Leu Lys Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Leu Gln Ser Gly Pro Glu 
145                 150                 155                 160 


Leu Glu Lys Pro Gly Ala Ser Val Met Ile Ser Cys Lys Ala Ser Gly 
                165                 170                 175     


Ser Ser Phe Thr Gly Tyr Asn Met Asn Trp Val Arg Gln Asn Ile Gly 
            180                 185                 190         


Lys Ser Leu Glu Trp Ile Gly Ala Ile Asp Pro Tyr Tyr Gly Gly Thr 
        195                 200                 205             


Ser Tyr Asn Gln Lys Phe Lys Gly Arg Ala Thr Leu Thr Val Asp Lys 
    210                 215                 220                 


Ser Ser Ser Thr Ala Tyr Met His Leu Lys Ser Leu Thr Ser Glu Asp 
225                 230                 235                 240 


Ser Ala Val Tyr Tyr Cys Val Ser Gly Met Glu Tyr Trp Gly Gln Gly 
                245                 250                 255     


Thr Ser Val Thr Val Ser Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro 
            260                 265                 270         


Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu 
        275                 280                 285             


Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp 
    290                 295                 300                 


Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly 
305                 310                 315                 320 


Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Arg Ser Lys Arg 
                325                 330                 335     


Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro 
            340                 345                 350         


Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe 
        355                 360                 365             


Ala Ala Tyr Arg Ser Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro 
    370                 375                 380                 


Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly 
385                 390                 395                 400 


Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro 
                405                 410                 415     


Glu Met Gly Gly Lys Pro Gln Arg Arg Lys Asn Pro Gln Glu Gly Leu 
            420                 425                 430         


Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile 
        435                 440                 445             


Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr 
    450                 455                 460                 


Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met 
465                 470                 475                 480 


Gln Ala Leu Pro Pro Arg Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu 
                485                 490                 495     


Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met Tyr Arg Met 
            500                 505                 510         


Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu Val Thr Asn Ser 
        515                 520                 525             


Gly Ile His Val Phe Ile Leu Gly Cys Phe Ser Ala Gly Leu Pro Lys 
    530                 535                 540                 


Thr Glu Ala Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys Ile Glu 
545                 550                 555                 560 


Asp Leu Ile Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr Glu Ser 
                565                 570                 575     


Asp Val His Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe Leu Leu 
            580                 585                 590         


Glu Leu Gln Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile His Asp 
        595                 600                 605             


Thr Val Glu Asn Leu Ile Ile Leu Ala Asn Asn Ser Leu Ser Ser Asn 
    610                 615                 620                 


Gly Asn Val Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu 
625                 630                 635                 640 


Lys Asn Ile Lys Glu Phe Leu Gln Ser Phe Val His Ile Val Gln Met 
                645                 650                 655     


Phe Ile Asn Thr Ser Ser Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
            660                 665                 670         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Leu Gln Ile 
        675                 680                 685             


Thr Cys Pro Pro Pro Met Ser Val Glu His Ala Asp Ile Trp Val Lys 
    690                 695                 700                 


Ser Tyr Ser Leu Tyr Ser Arg Glu Arg Tyr Ile Cys Asn Ser Gly Phe 
705                 710                 715                 720 


Lys Arg Lys Ala Gly Thr Ser Ser Leu Thr Glu Cys Val Leu Asn Lys 
                725                 730                 735     


Ala Thr Asn Val Ala His Trp Thr Thr Pro Ser Leu Lys Cys Ile Arg 
            740                 745                 750         


Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala 
        755                 760                 765             


Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly 
    770                 775                 780                 


Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Val Ala Ile 
785                 790                 795                 800 


Ser Thr Ser Thr Val Leu Leu Cys Gly Leu Ser Ala Val Ser Leu Leu 
                805                 810                 815     


Ala Cys Tyr 
            


<210>  232
<211>  2479
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  (GD2-28-IL-15/IL-15sushi anchor CAR nucleotide sequence)

<400>  232
gcgatcgcac catggcctta ccagtgaccg ccttgctcct gccgctggcc ttgctgctcc       60

acgccgccag gccggagatc gtgatgaccc agagccccgc caccctgagc gtgagccccg      120

gcgagagggc caccctgagc tgcaggagca gccagagcct ggtgcacagg aacggcaaca      180

cctacctgca ctggtacctg cagaagcccg gccagagccc caagctgctg atccacaagg      240

tgagcaacag gttcagcggc gtgcccgaca ggttcagcgg cagcggcagc ggcaccgact      300

tcaccctgaa gatcagcagg gtggaggccg aggacctggg cgtgtacttc tgcagccaga      360

gcacccacgt gccccccctg accttcggcg ccggcaccaa gctggagctg aagaggggcg      420

gcggcggcag cggcggcggc ggcagcggcg gcggcggcag cgaggtgcag ctgctgcaga      480

gcggccccga gctggagaag cccggcgcca gcgtgatgat cagctgcaag gccagcggca      540

gcagcttcac cggctacaac atgaactggg tgaggcagaa catcggcaag agcctggagt      600

ggatcggcgc catcgacccc tactacggcg gcaccagcta caaccagaag ttcaagggca      660

gggccaccct gaccgtggac aagagcagca gcaccgccta catgcacctg aagagcctga      720

ccagcgagga cagcgccgtg tactactgcg tgagcggcat ggagtactgg ggccagggca      780

ccagcgtgac cgtgagcagc accacgacgc cagcgccgcg accaccaaca ccggcgccca      840

ccatcgcgtc gcagcccctg tccctgcgcc cagaggcgtg ccggccagcg gcggggggcg      900

cagtgcacac gagggggctg gacttcgcct gtgatatcta catctgggcg cccttggccg      960

ggacttgtgg ggtccttctc ctgtcactgg ttatcaccct ttactgcagg agtaagagga     1020

gcaggctcct gcacagtgac tacatgaaca tgactccccg ccgccccggg cccacccgca     1080

agcattacca gccctatgcc ccaccacgcg acttcgcagc ctatcgctcc agagtgaagt     1140

tcagcaggag cgcagacgcc cccgcgtacc agcagggcca gaaccagctc tataacgagc     1200

tcaatctagg acgaagagag gagtacgatg ttttggacaa gagacgtggc cgggaccctg     1260

agatgggggg aaagccgcag agaaggaaga accctcagga aggcctgtac aatgaactgc     1320

agaaagataa gatggcggag gcctacagtg agattgggat gaaaggcgag cgccggaggg     1380

gcaaggggca cgatggcctt taccagggtc tcagtacagc caccaaggac acctacgacg     1440

cccttcacat gcaggccctg ccccctcgcg gaagcggagc caccaacttc agcctgctga     1500

agcaggccgg cgacgtggag gagaaccccg gccccatgta cagaatgcag ctgctgagct     1560

gcatcgccct gagcctggcc ctggtgacca acagcggcat ccacgtgttc atcctgggct     1620

gcttcagcgc cggcctgccc aagaccgagg ccaactgggt gaacgtgatc agcgacctga     1680

agaagatcga ggacctgatc cagagcatgc acatcgacgc caccctgtac accgagagcg     1740

acgtgcaccc cagctgcaag gtgaccgcca tgaagtgctt cctgctggag ctgcaggtga     1800

tcagcctgga gagcggcgac gccagcatcc acgacaccgt ggagaacctg atcatcctgg     1860

ccaacaacag cctgagcagc aacggcaacg tgaccgagag cggctgcaag gagtgcgagg     1920

agctggagga gaagaacatc aaggagttcc tgcagagctt cgtgcacatc gtgcagatgt     1980

tcatcaacac cagctccggc ggcggctccg gcggcggcgg ctccggcggc ggcggctccg     2040

gcggcggcgg ctccggcggc ggctccctgc agatcacctg cccccccccc atgagcgtgg     2100

agcacgccga catctgggtg aagagctaca gcctgtacag cagagagaga tacatctgca     2160

acagcggctt caagagaaag gccggcacca gcagcctgac cgagtgcgtg ctgaacaagg     2220

ccaccaacgt ggcccactgg accaccccca gcctgaagtg catcagaacc accacccccg     2280

cccccaggcc ccccaccccc gcccccacca tcgccagcca gcccctgagc ctgaggcccg     2340

aggcctgcag gcccgccgcc ggcggcgccg tgcacaccag gggcctggac ttcgcctgcg     2400

acgtggctat ctccacgtcc actgtcctgc tgtgtgggct gagcgctgtg tctctcctgg     2460

catgctacta agtttaaac                                                  2479


<210>  233
<211>  780
<212>  PRT
<213>  Artificial Sequence

<220>
<223>   (GD2-28-IL-15/IL-15sushi CAR amino acid sequence)

<400>  233

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu 
            20                  25                  30          


Ser Val Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ser Ser Gln 
        35                  40                  45              


Ser Leu Val His Arg Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln 
    50                  55                  60                  


Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile His Lys Val Ser Asn Arg 
65                  70                  75                  80  


Phe Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp 
                85                  90                  95      


Phe Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr 
            100                 105                 110         


Phe Cys Ser Gln Ser Thr His Val Pro Pro Leu Thr Phe Gly Ala Gly 
        115                 120                 125             


Thr Lys Leu Glu Leu Lys Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Leu Gln Ser Gly Pro Glu 
145                 150                 155                 160 


Leu Glu Lys Pro Gly Ala Ser Val Met Ile Ser Cys Lys Ala Ser Gly 
                165                 170                 175     


Ser Ser Phe Thr Gly Tyr Asn Met Asn Trp Val Arg Gln Asn Ile Gly 
            180                 185                 190         


Lys Ser Leu Glu Trp Ile Gly Ala Ile Asp Pro Tyr Tyr Gly Gly Thr 
        195                 200                 205             


Ser Tyr Asn Gln Lys Phe Lys Gly Arg Ala Thr Leu Thr Val Asp Lys 
    210                 215                 220                 


Ser Ser Ser Thr Ala Tyr Met His Leu Lys Ser Leu Thr Ser Glu Asp 
225                 230                 235                 240 


Ser Ala Val Tyr Tyr Cys Val Ser Gly Met Glu Tyr Trp Gly Gln Gly 
                245                 250                 255     


Thr Ser Val Thr Val Ser Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro 
            260                 265                 270         


Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu 
        275                 280                 285             


Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp 
    290                 295                 300                 


Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly 
305                 310                 315                 320 


Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Arg Ser Lys Arg 
                325                 330                 335     


Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro 
            340                 345                 350         


Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe 
        355                 360                 365             


Ala Ala Tyr Arg Ser Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro 
    370                 375                 380                 


Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly 
385                 390                 395                 400 


Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro 
                405                 410                 415     


Glu Met Gly Gly Lys Pro Gln Arg Arg Lys Asn Pro Gln Glu Gly Leu 
            420                 425                 430         


Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile 
        435                 440                 445             


Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr 
    450                 455                 460                 


Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met 
465                 470                 475                 480 


Gln Ala Leu Pro Pro Arg Gly Ser Gly Glu Gly Arg Gly Ser Leu Leu 
                485                 490                 495     


Thr Cys Gly Asp Val Glu Glu Asn Pro Gly Pro Met Tyr Arg Met Gln 
            500                 505                 510         


Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu Val Thr Asn Ser Gly 
        515                 520                 525             


Ile His Val Phe Ile Leu Gly Cys Phe Ser Ala Gly Leu Pro Lys Thr 
    530                 535                 540                 


Glu Ala Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys Ile Glu Asp 
545                 550                 555                 560 


Leu Ile Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr Glu Ser Asp 
                565                 570                 575     


Val His Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe Leu Leu Glu 
            580                 585                 590         


Leu Gln Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile His Asp Thr 
        595                 600                 605             


Val Glu Asn Leu Ile Ile Leu Ala Asn Asn Ser Leu Ser Ser Asn Gly 
    610                 615                 620                 


Asn Val Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu Lys 
625                 630                 635                 640 


Asn Ile Lys Glu Phe Leu Gln Ser Phe Val His Ile Val Gln Met Phe 
                645                 650                 655     


Ile Asn Thr Ser Ser Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
            660                 665                 670         


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Leu Gln Ala Pro 
        675                 680                 685             


Arg Arg Ala Arg Gly Cys Arg Thr Leu Gly Leu Pro Ala Leu Leu Leu 
    690                 695                 700                 


Leu Leu Leu Leu Arg Pro Pro Ala Thr Arg Gly Ile Thr Cys Pro Pro 
705                 710                 715                 720 


Pro Met Ser Val Glu His Ala Asp Ile Trp Val Lys Ser Tyr Ser Leu 
                725                 730                 735     


Tyr Ser Arg Glu Arg Tyr Ile Cys Asn Ser Gly Phe Lys Arg Lys Ala 
            740                 745                 750         


Gly Thr Ser Ser Leu Thr Glu Cys Val Leu Asn Lys Ala Thr Asn Val 
        755                 760                 765             


Ala His Trp Thr Thr Pro Ser Leu Lys Cys Ile Arg 
    770                 775                 780 


<210>  234
<211>  2362
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  (GD2-28-IL-15/IL-15sushi CAR nucleotide sequence)

<400>  234
gcgatcgcac catggcctta ccagtgaccg ccttgctcct gccgctggcc ttgctgctcc       60

acgccgccag gccggagatc gtgatgaccc agagccccgc caccctgagc gtgagccccg      120

gcgagagggc caccctgagc tgcaggagca gccagagcct ggtgcacagg aacggcaaca      180

cctacctgca ctggtacctg cagaagcccg gccagagccc caagctgctg atccacaagg      240

tgagcaacag gttcagcggc gtgcccgaca ggttcagcgg cagcggcagc ggcaccgact      300

tcaccctgaa gatcagcagg gtggaggccg aggacctggg cgtgtacttc tgcagccaga      360

gcacccacgt gccccccctg accttcggcg ccggcaccaa gctggagctg aagaggggcg      420

gcggcggcag cggcggcggc ggcagcggcg gcggcggcag cgaggtgcag ctgctgcaga      480

gcggccccga gctggagaag cccggcgcca gcgtgatgat cagctgcaag gccagcggca      540

gcagcttcac cggctacaac atgaactggg tgaggcagaa catcggcaag agcctggagt      600

ggatcggcgc catcgacccc tactacggcg gcaccagcta caaccagaag ttcaagggca      660

gggccaccct gaccgtggac aagagcagca gcaccgccta catgcacctg aagagcctga      720

ccagcgagga cagcgccgtg tactactgcg tgagcggcat ggagtactgg ggccagggca      780

ccagcgtgac cgtgagcagc accacgacgc cagcgccgcg accaccaaca ccggcgccca      840

ccatcgcgtc gcagcccctg tccctgcgcc cagaggcgtg ccggccagcg gcggggggcg      900

cagtgcacac gagggggctg gacttcgcct gtgatatcta catctgggcg cccttggccg      960

ggacttgtgg ggtccttctc ctgtcactgg ttatcaccct ttactgcagg agtaagagga     1020

gcaggctcct gcacagtgac tacatgaaca tgactccccg ccgccccggg cccacccgca     1080

agcattacca gccctatgcc ccaccacgcg acttcgcagc ctatcgctcc agagtgaagt     1140

tcagcaggag cgcagacgcc cccgcgtacc agcagggcca gaaccagctc tataacgagc     1200

tcaatctagg acgaagagag gagtacgatg ttttggacaa gagacgtggc cgggaccctg     1260

agatgggggg aaagccgcag agaaggaaga accctcagga aggcctgtac aatgaactgc     1320

agaaagataa gatggcggag gcctacagtg agattgggat gaaaggcgag cgccggaggg     1380

gcaaggggca cgatggcctt taccagggtc tcagtacagc caccaaggac acctacgacg     1440

cccttcacat gcaggccctg ccccctcgcg gcagcggcga aggccgcggc agcctgctga     1500

cctgcggcga tgtggaagaa aacccgggcc ccatgtacag aatgcagctg ctgagctgca     1560

tcgccctgag cctggccctg gtgaccaaca gcggcatcca cgtgttcatc ctgggctgct     1620

tcagcgccgg cctgcccaag accgaggcca actgggtgaa cgtgatcagc gacctgaaga     1680

agatcgagga cctgatccag agcatgcaca tcgacgccac cctgtacacc gagagcgacg     1740

tgcaccccag ctgcaaggtg accgccatga agtgcttcct gctggagctg caggtgatca     1800

gcctggagag cggcgacgcc agcatccacg acaccgtgga gaacctgatc atcctggcca     1860

acaacagcct gagcagcaac ggcaacgtga ccgagagcgg ctgcaaggag tgcgaggagc     1920

tggaggagaa gaacatcaag gagttcctgc agagcttcgt gcacatcgtg cagatgttca     1980

tcaacaccag ctccggcggc ggctccggcg gcggcggctc cggcggcggc ggctccggcg     2040

gcggcggctc cggcggcggc tccctgcagg cccccagaag agccagaggc tgcagaaccc     2100

tgggcctgcc cgccctgctg ctgctgctgc tgctgagacc ccccgccacc agaggcatca     2160

cctgcccccc ccccatgagc gtggagcacg ccgacatctg ggtgaagagc tacagcctgt     2220

acagcagaga gagatacatc tgcaacagcg gcttcaagag aaaggccggc accagcagcc     2280

tgaccgagtg cgtgctgaac aaggccacca acgtggccca ctggaccacc cccagcctga     2340

agtgcatcag ataagtttaa ac                                              2362


<210>  235
<211>  993
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  (GD2-BB-GD3-28-2G cCAR amino acid sequence)

<400>  235

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu 
            20                  25                  30          


Ser Val Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ser Ser Gln 
        35                  40                  45              


Ser Leu Val His Arg Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln 
    50                  55                  60                  


Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile His Lys Val Ser Asn Arg 
65                  70                  75                  80  


Phe Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp 
                85                  90                  95      


Phe Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr 
            100                 105                 110         


Phe Cys Ser Gln Ser Thr His Val Pro Pro Leu Thr Phe Gly Ala Gly 
        115                 120                 125             


Thr Lys Leu Glu Leu Lys Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Leu Gln Ser Gly Pro Glu 
145                 150                 155                 160 


Leu Glu Lys Pro Gly Ala Ser Val Met Ile Ser Cys Lys Ala Ser Gly 
                165                 170                 175     


Ser Ser Phe Thr Gly Tyr Asn Met Asn Trp Val Arg Gln Asn Ile Gly 
            180                 185                 190         


Lys Ser Leu Glu Trp Ile Gly Ala Ile Asp Pro Tyr Tyr Gly Gly Thr 
        195                 200                 205             


Ser Tyr Asn Gln Lys Phe Lys Gly Arg Ala Thr Leu Thr Val Asp Lys 
    210                 215                 220                 


Ser Ser Ser Thr Ala Tyr Met His Leu Lys Ser Leu Thr Ser Glu Asp 
225                 230                 235                 240 


Ser Ala Val Tyr Tyr Cys Val Ser Gly Met Glu Tyr Trp Gly Gln Gly 
                245                 250                 255     


Thr Ser Val Thr Val Ser Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro 
            260                 265                 270         


Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu 
        275                 280                 285             


Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp 
    290                 295                 300                 


Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly 
305                 310                 315                 320 


Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Arg Ser Lys Arg 
                325                 330                 335     


Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro 
            340                 345                 350         


Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe 
        355                 360                 365             


Ala Ala Tyr Arg Ser Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro 
    370                 375                 380                 


Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly 
385                 390                 395                 400 


Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro 
                405                 410                 415     


Glu Met Gly Gly Lys Pro Gln Arg Arg Lys Asn Pro Gln Glu Gly Leu 
            420                 425                 430         


Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile 
        435                 440                 445             


Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr 
    450                 455                 460                 


Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met 
465                 470                 475                 480 


Gln Ala Leu Pro Pro Arg Gly Ser Gly Glu Gly Arg Gly Ser Leu Leu 
                485                 490                 495     


Thr Cys Gly Asp Val Glu Glu Asn Pro Gly Pro Met Ala Leu Pro Val 
            500                 505                 510         


Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu His Ala Ala Arg Pro 
        515                 520                 525             


Glu Val Thr Leu Val Glu Ser Gly Gly Asp Phe Val Lys Pro Gly Gly 
    530                 535                 540                 


Ser Leu Lys Val Ser Cys Ala Ala Ser Gly Phe Ala Phe Ser His Tyr 
545                 550                 555                 560 


Ala Met Ser Trp Val Arg Gln Thr Pro Ala Lys Arg Leu Glu Trp Val 
                565                 570                 575     


Ala Tyr Ile Ser Ser Gly Gly Ser Gly Thr Tyr Tyr Ser Asp Ser Val 
            580                 585                 590         


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
        595                 600                 605             


Leu Gln Met Arg Ser Leu Arg Ser Glu Asp Ser Ala Met Tyr Phe Cys 
    610                 615                 620                 


Thr Arg Val Lys Leu Gly Thr Tyr Tyr Phe Asp Ser Trp Gly Gln Gly 
625                 630                 635                 640 


Thr Thr Leu Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
                645                 650                 655     


Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Thr Ala Ser Ser 
            660                 665                 670         


Leu Pro Ala Ser Leu Gly Asp Arg Val Thr Ile Ser Cys Ser Ala Ser 
        675                 680                 685             


Gln Asp Ile Ser Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly 
    690                 695                 700                 


Thr Val Lys Leu Leu Ile Phe Tyr Ser Ser Asn Leu His Ser Gly Val 
705                 710                 715                 720 


Pro Ser Arg Phe Ser Gly Gly Gly Ser Gly Thr Asp Tyr Ser Leu Thr 
                725                 730                 735     


Ile Ser Asn Leu Glu Pro Glu Asp Ile Ala Thr Tyr Phe Cys His Gln 
            740                 745                 750         


Tyr Ser Lys Leu Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile 
        755                 760                 765             


Lys Arg Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr 
    770                 775                 780                 


Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala 
785                 790                 795                 800 


Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile 
                805                 810                 815     


Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser 
            820                 825                 830         


Leu Val Ile Thr Leu Tyr Cys Arg Ser Lys Arg Ser Arg Leu Leu His 
        835                 840                 845             


Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys 
    850                 855                 860                 


His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser 
865                 870                 875                 880 


Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly 
                885                 890                 895     


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
            900                 905                 910         


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
        915                 920                 925             


Pro Gln Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln 
    930                 935                 940                 


Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu 
945                 950                 955                 960 


Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr 
                965                 970                 975     


Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro 
            980                 985                 990         


Arg 
    


<210>  236
<211>  3001
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  (GD2-BB-GD3-28-2G cCAR nucleotide sequence)

<400>  236
gcgatcgcac catggcctta ccagtgaccg ccttgctcct gccgctggcc ttgctgctcc       60

acgccgccag gccggagatc gtgatgaccc agagccccgc caccctgagc gtgagccccg      120

gcgagagggc caccctgagc tgcaggagca gccagagcct ggtgcacagg aacggcaaca      180

cctacctgca ctggtacctg cagaagcccg gccagagccc caagctgctg atccacaagg      240

tgagcaacag gttcagcggc gtgcccgaca ggttcagcgg cagcggcagc ggcaccgact      300

tcaccctgaa gatcagcagg gtggaggccg aggacctggg cgtgtacttc tgcagccaga      360

gcacccacgt gccccccctg accttcggcg ccggcaccaa gctggagctg aagaggggcg      420

gcggcggcag cggcggcggc ggcagcggcg gcggcggcag cgaggtgcag ctgctgcaga      480

gcggccccga gctggagaag cccggcgcca gcgtgatgat cagctgcaag gccagcggca      540

gcagcttcac cggctacaac atgaactggg tgaggcagaa catcggcaag agcctggagt      600

ggatcggcgc catcgacccc tactacggcg gcaccagcta caaccagaag ttcaagggca      660

gggccaccct gaccgtggac aagagcagca gcaccgccta catgcacctg aagagcctga      720

ccagcgagga cagcgccgtg tactactgcg tgagcggcat ggagtactgg ggccagggca      780

ccagcgtgac cgtgagcagc accacgacgc cagcgccgcg accaccaaca ccggcgccca      840

ccatcgcgtc gcagcccctg tccctgcgcc cagaggcgtg ccggccagcg gcggggggcg      900

cagtgcacac gagggggctg gacttcgcct gtgatatcta catctgggcg cccttggccg      960

ggacttgtgg ggtccttctc ctgtcactgg ttatcaccct ttactgcagg agtaagagga     1020

gcaggctcct gcacagtgac tacatgaaca tgactccccg ccgccccggg cccacccgca     1080

agcattacca gccctatgcc ccaccacgcg acttcgcagc ctatcgctcc agagtgaagt     1140

tcagcaggag cgcagacgcc cccgcgtacc agcagggcca gaaccagctc tataacgagc     1200

tcaatctagg acgaagagag gagtacgatg ttttggacaa gagacgtggc cgggaccctg     1260

agatgggggg aaagccgcag agaaggaaga accctcagga aggcctgtac aatgaactgc     1320

agaaagataa gatggcggag gcctacagtg agattgggat gaaaggcgag cgccggaggg     1380

gcaaggggca cgatggcctt taccagggtc tcagtacagc caccaaggac acctacgacg     1440

cccttcacat gcaggccctg ccccctcgcg gcagcggcga aggccgcggc agcctgctga     1500

cctgcggcga tgtggaagaa aacccgggcc ccatggcctt accagtgacc gccttgctcc     1560

tgccgctggc cttgctgctc cacgccgcca ggccggaggt gaccctggtg gagagcggcg     1620

gcgacttcgt gaagcccggc ggcagcctga aggtgagctg cgccgccagc ggcttcgcct     1680

tcagccacta cgccatgagc tgggtgaggc agacccccgc caagaggctg gagtgggtgg     1740

cctacatcag cagcggcggc agcggcacct actacagcga cagcgtgaag ggcaggttca     1800

ccatcagcag ggacaacgcc aagaacaccc tgtacctgca gatgaggagc ctgaggagcg     1860

aggacagcgc catgtacttc tgcaccaggg tgaagctggg cacctactac ttcgacagct     1920

ggggccaggg caccaccctg accgtgagca gcggaggggg gggatccggg ggaggaggct     1980

ccggcggagg cggaagcgac atccagatga cccagaccgc cagcagcctg cccgccagcc     2040

tgggcgacag ggtgaccatc agctgcagcg ccagccagga catcagcaac tacctgaact     2100

ggtaccagca gaagcccgac ggcaccgtga agctgctgat cttctacagc agcaacctgc     2160

acagcggcgt gcccagcagg ttcagcggcg gcggcagcgg caccgactac agcctgacca     2220

tcagcaacct ggagcccgag gacatcgcca cctacttctg ccaccagtac agcaagctgc     2280

cctggacctt cggcggcggc accaagctgg agatcaagag gaccacgacg ccagcgccgc     2340

gaccaccaac accggcgccc accatcgcgt cgcagcccct gtccctgcgc ccagaggcgt     2400

gccggccagc ggcggggggc gcagtgcaca cgagggggct ggacttcgcc tgtgatatct     2460

acatctgggc gcccttggcc gggacttgtg gggtccttct cctgtcactg gttatcaccc     2520

tttactgcag gagtaagagg agcaggctcc tgcacagtga ctacatgaac atgactcccc     2580

gccgccccgg gcccacccgc aagcattacc agccctatgc cccaccacgc gacttcgcag     2640

cctatcgctc cagagtgaag ttcagcagga gcgcagacgc ccccgcgtac cagcagggcc     2700

agaaccagct ctataacgag ctcaatctag gacgaagaga ggagtacgat gttttggaca     2760

agagacgtgg ccgggaccct gagatggggg gaaagccgca gagaaggaag aaccctcagg     2820

aaggcctgta caatgaactg cagaaagata agatggcgga ggcctacagt gagattggga     2880

tgaaaggcga gcgccggagg ggcaaggggc acgatggcct ttaccagggt ctcagtacag     2940

ccaccaagga cacctacgac gcccttcaca tgcaggccct gccccctcgc taagtttaaa     3000

c                                                                     3001


<210>  237
<211>  487
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  (GD2-BBpre-2G CAR amino acid sequence)

<400>  237

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu 
            20                  25                  30          


Ser Val Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ser Ser Gln 
        35                  40                  45              


Ser Leu Val His Arg Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln 
    50                  55                  60                  


Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile His Lys Val Ser Asn Arg 
65                  70                  75                  80  


Phe Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp 
                85                  90                  95      


Phe Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr 
            100                 105                 110         


Phe Cys Ser Gln Ser Thr His Val Pro Pro Leu Thr Phe Gly Ala Gly 
        115                 120                 125             


Thr Lys Leu Glu Leu Lys Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Leu Gln Ser Gly Pro Glu 
145                 150                 155                 160 


Leu Glu Lys Pro Gly Ala Ser Val Met Ile Ser Cys Lys Ala Ser Gly 
                165                 170                 175     


Ser Ser Phe Thr Gly Tyr Asn Met Asn Trp Val Arg Gln Asn Ile Gly 
            180                 185                 190         


Lys Ser Leu Glu Trp Ile Gly Ala Ile Asp Pro Tyr Tyr Gly Gly Thr 
        195                 200                 205             


Ser Tyr Asn Gln Lys Phe Lys Gly Arg Ala Thr Leu Thr Val Asp Lys 
    210                 215                 220                 


Ser Ser Ser Thr Ala Tyr Met His Leu Lys Ser Leu Thr Ser Glu Asp 
225                 230                 235                 240 


Ser Ala Val Tyr Tyr Cys Val Ser Gly Met Glu Tyr Trp Gly Gln Gly 
                245                 250                 255     


Thr Ser Val Thr Val Ser Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro 
            260                 265                 270         


Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu 
        275                 280                 285             


Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp 
    290                 295                 300                 


Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly 
305                 310                 315                 320 


Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg 
                325                 330                 335     


Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln 
            340                 345                 350         


Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu 
        355                 360                 365             


Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala 
    370                 375                 380                 


Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu 
385                 390                 395                 400 


Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp 
                405                 410                 415     


Pro Glu Met Gly Gly Lys Pro Gln Arg Arg Lys Asn Pro Gln Glu Gly 
            420                 425                 430         


Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu 
        435                 440                 445             


Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu 
    450                 455                 460                 


Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His 
465                 470                 475                 480 


Met Gln Ala Leu Pro Pro Arg 
                485         


<210>  238
<211>  1483
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  (GD2-BBpre-2G CAR nucleotide sequence)

<400>  238
gcgatcgcac catggccctg cccgtgaccg ccctgctgct gcccctggcc ctgctgctgc       60

acgccgccag gcccgagatc gtgatgaccc agagccccgc caccctgagc gtgagccccg      120

gcgagagggc caccctgagc tgcaggagca gccagagcct ggtgcacagg aacggcaaca      180

cctacctgca ctggtacctg cagaagcccg gccagagccc caagctgctg atccacaagg      240

tgagcaacag gttcagcggc gtgcccgaca ggttcagcgg cagcggcagc ggcaccgact      300

tcaccctgaa gatcagcagg gtggaggccg aggacctggg cgtgtacttc tgcagccaga      360

gcacccacgt gccccccctg accttcggcg ccggcaccaa gctggagctg aagaggggcg      420

gcggcggcag cggcggcggc ggcagcggcg gcggcggcag cgaggtgcag ctgctgcaga      480

gcggccccga gctggagaag cccggcgcca gcgtgatgat cagctgcaag gccagcggca      540

gcagcttcac cggctacaac atgaactggg tgaggcagaa catcggcaag agcctggagt      600

ggatcggcgc catcgacccc tactacggcg gcaccagcta caaccagaag ttcaagggca      660

gggccaccct gaccgtggac aagagcagca gcaccgccta catgcacctg aagagcctga      720

ccagcgagga cagcgccgtg tactactgcg tgagcggcat ggagtactgg ggccagggca      780

ccagcgtgac cgtgagcagc accaccaccc ccgcccccag gccccccacc cccgccccca      840

ccatcgccag ccagcccctg agcctgaggc ccgaggcctg caggcccgcc gccggcggcg      900

ccgtgcacac caggggcctg gacttcgcct gcgacatcta catctgggcc cccctggccg      960

gcacctgcgg cgtgctgctg ctgagcctgg tgatcaccct gtactgcaaa cggggcagaa     1020

agaaactcct gtatatattc aaacaaccat ttatgagacc agtacaaact actcaagagg     1080

aagatggctg tagctgccga tttccagaag aagaagaagg aggatgtgaa ctgagggtga     1140

agttcagcag gagcgccgac gcccccgcct accagcaggg ccagaaccag ctgtacaacg     1200

agctgaacct gggcaggagg gaggagtacg acgtgctgga caagaggagg ggcagggacc     1260

ccgagatggg cggcaagccc cagaggagga agaaccccca ggagggcctg tacaacgagc     1320

tgcagaagga caagatggcc gaggcctaca gcgagatcgg catgaagggc gagaggagga     1380

ggggcaaggg ccacgacggc ctgtaccagg gcctgagcac cgccaccaag gacacctacg     1440

acgccctgca catgcaggcc ctgcccccca ggtaagttta aac                       1483


<210>  239
<211>  477
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  (GD3-28-2G CAR amino acid sequence)

<400>  239

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Val Thr Leu Val Glu Ser Gly Gly Asp Phe 
            20                  25                  30          


Val Lys Pro Gly Gly Ser Leu Lys Val Ser Cys Ala Ala Ser Gly Phe 
        35                  40                  45              


Ala Phe Ser His Tyr Ala Met Ser Trp Val Arg Gln Thr Pro Ala Lys 
    50                  55                  60                  


Arg Leu Glu Trp Val Ala Tyr Ile Ser Ser Gly Gly Ser Gly Thr Tyr 
65                  70                  75                  80  


Tyr Ser Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala 
                85                  90                  95      


Lys Asn Thr Leu Tyr Leu Gln Met Arg Ser Leu Arg Ser Glu Asp Ser 
            100                 105                 110         


Ala Met Tyr Phe Cys Thr Arg Val Lys Leu Gly Thr Tyr Tyr Phe Asp 
        115                 120                 125             


Ser Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr 
145                 150                 155                 160 


Gln Thr Ala Ser Ser Leu Pro Ala Ser Leu Gly Asp Arg Val Thr Ile 
                165                 170                 175     


Ser Cys Ser Ala Ser Gln Asp Ile Ser Asn Tyr Leu Asn Trp Tyr Gln 
            180                 185                 190         


Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile Phe Tyr Ser Ser Asn 
        195                 200                 205             


Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly Gly Gly Ser Gly Thr 
    210                 215                 220                 


Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Pro Glu Asp Ile Ala Thr 
225                 230                 235                 240 


Tyr Phe Cys His Gln Tyr Ser Lys Leu Pro Trp Thr Phe Gly Gly Gly 
                245                 250                 255     


Thr Lys Leu Glu Ile Lys Arg Thr Thr Thr Pro Ala Pro Arg Pro Pro 
            260                 265                 270         


Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu 
        275                 280                 285             


Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp 
    290                 295                 300                 


Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly 
305                 310                 315                 320 


Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Arg Ser Lys Arg 
                325                 330                 335     


Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro 
            340                 345                 350         


Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe 
        355                 360                 365             


Ala Ala Tyr Arg Ser Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro 
    370                 375                 380                 


Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly 
385                 390                 395                 400 


Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro 
                405                 410                 415     


Glu Met Gly Gly Lys Pro Gln Arg Arg Lys Asn Pro Gln Glu Gly Leu 
            420                 425                 430         


Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile 
        435                 440                 445             


Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr 
    450                 455                 460                 


Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala 
465                 470                 475         


<210>  240
<211>  1480
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  (GD3-28-2G CAR nucleotide sequence)

<400>  240
gcgatcgcac catggcctta ccagtgaccg ccttgctcct gccgctggcc ttgctgctcc       60

acgccgccag gccggaggtg accctggtgg agagcggcgg cgacttcgtg aagcccggcg      120

gcagcctgaa ggtgagctgc gccgccagcg gcttcgcctt cagccactac gccatgagct      180

gggtgaggca gacccccgcc aagaggctgg agtgggtggc ctacatcagc agcggcggca      240

gcggcaccta ctacagcgac agcgtgaagg gcaggttcac catcagcagg gacaacgcca      300

agaacaccct gtacctgcag atgaggagcc tgaggagcga ggacagcgcc atgtacttct      360

gcaccagggt gaagctgggc acctactact tcgacagctg gggccagggc accaccctga      420

ccgtgagcag cggagggggg ggatccgggg gaggaggctc cggcggaggc ggaagcgaca      480

tccagatgac ccagaccgcc agcagcctgc ccgccagcct gggcgacagg gtgaccatca      540

gctgcagcgc cagccaggac atcagcaact acctgaactg gtaccagcag aagcccgacg      600

gcaccgtgaa gctgctgatc ttctacagca gcaacctgca cagcggcgtg cccagcaggt      660

tcagcggcgg cggcagcggc accgactaca gcctgaccat cagcaacctg gagcccgagg      720

acatcgccac ctacttctgc caccagtaca gcaagctgcc ctggaccttc ggcggcggca      780

ccaagctgga gatcaagagg accacgacgc cagcgccgcg accaccaaca ccggcgccca      840

ccatcgcgtc gcagcccctg tccctgcgcc cagaggcgtg ccggccagcg gcggggggcg      900

cagtgcacac gagggggctg gacttcgcct gtgatatcta catctgggcg cccttggccg      960

ggacttgtgg ggtccttctc ctgtcactgg ttatcaccct ttactgcagg agtaagagga     1020

gcaggctcct gcacagtgac tacatgaaca tgactccccg ccgccccggg cccacccgca     1080

agcattacca gccctatgcc ccaccacgcg acttcgcagc ctatcgctcc agagtgaagt     1140

tcagcaggag cgcagacgcc cccgcgtacc agcagggcca gaaccagctc tataacgagc     1200

tcaatctagg acgaagagag gagtacgatg ttttggacaa gagacgtggc cgggaccctg     1260

agatgggggg aaagccgcag agaaggaaga accctcagga aggcctgtac aatgaactgc     1320

agaaagataa gatggcggag gcctacagtg agattgggat gaaaggcgag cgccggaggg     1380

gcaaggggca cgatggcctt taccagggtc tcagtacagc caccaaggac acctacgacg     1440

cccttcacat gcaggccctg ccccctcgct aagtttaaac                           1480


<210>  241
<211>  1057
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  (GD3-28-2G-4-1BBL-IL15/IL-15sushi CAR amino acid sequence)

<400>  241

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Val Thr Leu Val Glu Ser Gly Gly Asp Phe 
            20                  25                  30          


Val Lys Pro Gly Gly Ser Leu Lys Val Ser Cys Ala Ala Ser Gly Phe 
        35                  40                  45              


Ala Phe Ser His Tyr Ala Met Ser Trp Val Arg Gln Thr Pro Ala Lys 
    50                  55                  60                  


Arg Leu Glu Trp Val Ala Tyr Ile Ser Ser Gly Gly Ser Gly Thr Tyr 
65                  70                  75                  80  


Tyr Ser Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala 
                85                  90                  95      


Lys Asn Thr Leu Tyr Leu Gln Met Arg Ser Leu Arg Ser Glu Asp Ser 
            100                 105                 110         


Ala Met Tyr Phe Cys Thr Arg Val Lys Leu Gly Thr Tyr Tyr Phe Asp 
        115                 120                 125             


Ser Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr 
145                 150                 155                 160 


Gln Thr Ala Ser Ser Leu Pro Ala Ser Leu Gly Asp Arg Val Thr Ile 
                165                 170                 175     


Ser Cys Ser Ala Ser Gln Asp Ile Ser Asn Tyr Leu Asn Trp Tyr Gln 
            180                 185                 190         


Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile Phe Tyr Ser Ser Asn 
        195                 200                 205             


Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly Gly Gly Ser Gly Thr 
    210                 215                 220                 


Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Pro Glu Asp Ile Ala Thr 
225                 230                 235                 240 


Tyr Phe Cys His Gln Tyr Ser Lys Leu Pro Trp Thr Phe Gly Gly Gly 
                245                 250                 255     


Thr Lys Leu Glu Ile Lys Arg Thr Thr Thr Pro Ala Pro Arg Pro Pro 
            260                 265                 270         


Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu 
        275                 280                 285             


Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp 
    290                 295                 300                 


Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly 
305                 310                 315                 320 


Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Arg Ser Lys Arg 
                325                 330                 335     


Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro 
            340                 345                 350         


Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe 
        355                 360                 365             


Ala Ala Tyr Arg Ser Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro 
    370                 375                 380                 


Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly 
385                 390                 395                 400 


Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro 
                405                 410                 415     


Glu Met Gly Gly Lys Pro Gln Arg Arg Lys Asn Pro Gln Glu Gly Leu 
            420                 425                 430         


Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile 
        435                 440                 445             


Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr 
    450                 455                 460                 


Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met 
465                 470                 475                 480 


Gln Ala Leu Pro Pro Arg Gly Ser Gly Glu Gly Arg Gly Ser Leu Leu 
                485                 490                 495     


Thr Cys Gly Asp Val Glu Glu Asn Pro Gly Pro Met Glu Tyr Ala Ser 
            500                 505                 510         


Asp Ala Ser Leu Asp Pro Glu Ala Pro Trp Pro Pro Ala Pro Arg Ala 
        515                 520                 525             


Arg Ala Cys Arg Val Leu Pro Trp Ala Leu Val Ala Gly Leu Leu Leu 
    530                 535                 540                 


Leu Leu Leu Leu Ala Ala Ala Cys Ala Val Phe Leu Ala Cys Pro Trp 
545                 550                 555                 560 


Ala Val Ser Gly Ala Arg Ala Ser Pro Gly Ser Ala Ala Ser Pro Arg 
                565                 570                 575     


Leu Arg Glu Gly Pro Glu Leu Ser Pro Asp Asp Pro Ala Gly Leu Leu 
            580                 585                 590         


Asp Leu Arg Gln Gly Met Phe Ala Gln Leu Val Ala Gln Asn Val Leu 
        595                 600                 605             


Leu Ile Asp Gly Pro Leu Ser Trp Tyr Ser Asp Pro Gly Leu Ala Gly 
    610                 615                 620                 


Val Ser Leu Thr Gly Gly Leu Ser Tyr Lys Glu Asp Thr Lys Glu Leu 
625                 630                 635                 640 


Val Val Ala Lys Ala Gly Val Tyr Tyr Val Phe Phe Gln Leu Glu Leu 
                645                 650                 655     


Arg Arg Val Val Ala Gly Glu Gly Ser Gly Ser Val Ser Leu Ala Leu 
            660                 665                 670         


His Leu Gln Pro Leu Arg Ser Ala Ala Gly Ala Ala Ala Leu Ala Leu 
        675                 680                 685             


Thr Val Asp Leu Pro Pro Ala Ser Ser Glu Ala Arg Asn Ser Ala Phe 
    690                 695                 700                 


Gly Phe Gln Gly Arg Leu Leu His Leu Ser Ala Gly Gln Arg Leu Gly 
705                 710                 715                 720 


Val His Leu His Thr Glu Ala Arg Ala Arg His Ala Trp Gln Leu Thr 
                725                 730                 735     


Gln Gly Ala Thr Val Leu Gly Leu Phe Arg Val Thr Pro Glu Ile Pro 
            740                 745                 750         


Ala Gly Leu Pro Ser Pro Arg Ser Glu Gly Ser Gly Ala Thr Asn Phe 
        755                 760                 765             


Leu Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro 
    770                 775                 780                 


Met Tyr Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu 
785                 790                 795                 800 


Val Thr Asn Ser Gly Ile His Val Phe Ile Leu Gly Cys Phe Ser Ala 
                805                 810                 815     


Gly Leu Pro Lys Thr Glu Ala Asn Trp Val Asn Val Ile Ser Asp Leu 
            820                 825                 830         


Lys Lys Ile Glu Asp Leu Ile Gln Ser Met His Ile Asp Ala Thr Leu 
        835                 840                 845             


Tyr Thr Glu Ser Asp Val His Pro Ser Cys Lys Val Thr Ala Met Lys 
    850                 855                 860                 


Cys Phe Leu Leu Glu Leu Gln Val Ile Ser Leu Glu Ser Gly Asp Ala 
865                 870                 875                 880 


Ser Ile His Asp Thr Val Glu Asn Leu Ile Ile Leu Ala Asn Asn Ser 
                885                 890                 895     


Leu Ser Ser Asn Gly Asn Val Thr Glu Ser Gly Cys Lys Glu Cys Glu 
            900                 905                 910         


Glu Leu Glu Glu Lys Asn Ile Lys Glu Phe Leu Gln Ser Phe Val His 
        915                 920                 925             


Ile Val Gln Met Phe Ile Asn Thr Ser Ser Gly Gly Gly Ser Gly Gly 
    930                 935                 940                 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
945                 950                 955                 960 


Ser Leu Gln Ala Pro Arg Arg Ala Arg Gly Cys Arg Thr Leu Gly Leu 
                965                 970                 975     


Pro Ala Leu Leu Leu Leu Leu Leu Leu Arg Pro Pro Ala Thr Arg Gly 
            980                 985                 990         


Ile Thr Cys Pro Pro Pro Met Ser  Val Glu His Ala Asp  Ile Trp Val 
        995                 1000                 1005             


Lys Ser  Tyr Ser Leu Tyr Ser  Arg Glu Arg Tyr Ile  Cys Asn Ser 
    1010                 1015                 1020             


Gly Phe  Lys Arg Lys Ala Gly  Thr Ser Ser Leu Thr  Glu Cys Val 
    1025                 1030                 1035             


Leu Asn  Lys Ala Thr Asn Val  Ala His Trp Thr Thr  Pro Ser Leu 
    1040                 1045                 1050             


Lys Cys  Ile Arg 
    1055         


<210>  242
<211>  3193
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  (GD3-28-2G-4-1BBL-IL15/IL-15sushi nucleotide sequence)

<400>  242
gcgatcgcac catggcctta ccagtgaccg ccttgctcct gccgctggcc ttgctgctcc       60

acgccgccag gccggaggtg accctggtgg agagcggcgg cgacttcgtg aagcccggcg      120

gcagcctgaa ggtgagctgc gccgccagcg gcttcgcctt cagccactac gccatgagct      180

gggtgaggca gacccccgcc aagaggctgg agtgggtggc ctacatcagc agcggcggca      240

gcggcaccta ctacagcgac agcgtgaagg gcaggttcac catcagcagg gacaacgcca      300

agaacaccct gtacctgcag atgaggagcc tgaggagcga ggacagcgcc atgtacttct      360

gcaccagggt gaagctgggc acctactact tcgacagctg gggccagggc accaccctga      420

ccgtgagcag cggagggggg ggatccgggg gaggaggctc cggcggaggc ggaagcgaca      480

tccagatgac ccagaccgcc agcagcctgc ccgccagcct gggcgacagg gtgaccatca      540

gctgcagcgc cagccaggac atcagcaact acctgaactg gtaccagcag aagcccgacg      600

gcaccgtgaa gctgctgatc ttctacagca gcaacctgca cagcggcgtg cccagcaggt      660

tcagcggcgg cggcagcggc accgactaca gcctgaccat cagcaacctg gagcccgagg      720

acatcgccac ctacttctgc caccagtaca gcaagctgcc ctggaccttc ggcggcggca      780

ccaagctgga gatcaagagg accacgacgc cagcgccgcg accaccaaca ccggcgccca      840

ccatcgcgtc gcagcccctg tccctgcgcc cagaggcgtg ccggccagcg gcggggggcg      900

cagtgcacac gagggggctg gacttcgcct gtgatatcta catctgggcg cccttggccg      960

ggacttgtgg ggtccttctc ctgtcactgg ttatcaccct ttactgcagg agtaagagga     1020

gcaggctcct gcacagtgac tacatgaaca tgactccccg ccgccccggg cccacccgca     1080

agcattacca gccctatgcc ccaccacgcg acttcgcagc ctatcgctcc agagtgaagt     1140

tcagcaggag cgcagacgcc cccgcgtacc agcagggcca gaaccagctc tataacgagc     1200

tcaatctagg acgaagagag gagtacgatg ttttggacaa gagacgtggc cgggaccctg     1260

agatgggggg aaagccgcag agaaggaaga accctcagga aggcctgtac aatgaactgc     1320

agaaagataa gatggcggag gcctacagtg agattgggat gaaaggcgag cgccggaggg     1380

gcaaggggca cgatggcctt taccagggtc tcagtacagc caccaaggac acctacgacg     1440

cccttcacat gcaggccctg ccccctcgcg gcagcggcga aggccgcggc agcctgctga     1500

cctgcggcga tgtggaagaa aacccgggcc ccatggaata cgcctctgac gcttcactgg     1560

accccgaagc cccgtggcct cccgcgcccc gcgctcgcgc ctgccgcgta ctgccttggg     1620

ccctggtcgc ggggctgctg ctgctgctgc tgctcgctgc cgcctgcgcc gtcttcctcg     1680

cctgcccctg ggccgtgtcc ggggctcgcg cctcgcccgg ctccgcggcc agcccgagac     1740

tccgcgaggg tcccgagctt tcgcccgacg atcccgccgg cctcttggac ctgcggcagg     1800

gcatgtttgc gcagctggtg gcccaaaatg ttctgctgat cgatgggccc ctgagctggt     1860

acagtgaccc aggcctggca ggcgtgtccc tgacgggggg cctgagctac aaagaggaca     1920

cgaaggagct ggtggtggcc aaggctggag tctactatgt cttctttcaa ctagagctgc     1980

ggcgcgtggt ggccggcgag ggctcaggct ccgtttcact tgcgctgcac ctgcagccac     2040

tgcgctctgc tgctggggcc gccgccctgg ctttgaccgt ggacctgcca cccgcctcct     2100

ccgaggctcg gaactcggcc ttcggtttcc agggccgctt gctgcacctg agtgccggcc     2160

agcgcctggg cgtccatctt cacactgagg ccagggcacg ccatgcctgg cagcttaccc     2220

agggcgccac agtcttggga ctcttccggg tgacccccga aatcccagcc ggactccctt     2280

caccgaggtc ggaaggaagc ggagctacta acttcttgag cctgctgaag caggctggag     2340

acgtggagga gaaccctgga cctatgtaca gaatgcagct gctgagctgc atcgccctga     2400

gcctggccct ggtgaccaac agcggcatcc acgtgttcat cctgggctgc ttcagcgccg     2460

gcctgcccaa gaccgaggcc aactgggtga acgtgatcag cgacctgaag aagatcgagg     2520

acctgatcca gagcatgcac atcgacgcca ccctgtacac cgagagcgac gtgcacccca     2580

gctgcaaggt gaccgccatg aagtgcttcc tgctggagct gcaggtgatc agcctggaga     2640

gcggcgacgc cagcatccac gacaccgtgg agaacctgat catcctggcc aacaacagcc     2700

tgagcagcaa cggcaacgtg accgagagcg gctgcaagga gtgcgaggag ctggaggaga     2760

agaacatcaa ggagttcctg cagagcttcg tgcacatcgt gcagatgttc atcaacacca     2820

gctccggcgg cggctccggc ggcggcggct ccggcggcgg cggctccggc ggcggcggct     2880

ccggcggcgg ctccctgcag gcccccagaa gagccagagg ctgcagaacc ctgggcctgc     2940

ccgccctgct gctgctgctg ctgctgagac cccccgccac cagaggcatc acctgccccc     3000

cccccatgag cgtggagcac gccgacatct gggtgaagag ctacagcctg tacagcagag     3060

agagatacat ctgcaacagc ggcttcaaga gaaaggccgg caccagcagc ctgaccgagt     3120

gcgtgctgaa caaggccacc aacgtggccc actggaccac ccccagcctg aagtgcatca     3180

gataagttta aac                                                        3193


<210>  243
<211>  661
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  (GD3-28-2G-IL15xp CAR amino acid sequence)

<400>  243

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Val Thr Leu Val Glu Ser Gly Gly Asp Phe 
            20                  25                  30          


Val Lys Pro Gly Gly Ser Leu Lys Val Ser Cys Ala Ala Ser Gly Phe 
        35                  40                  45              


Ala Phe Ser His Tyr Ala Met Ser Trp Val Arg Gln Thr Pro Ala Lys 
    50                  55                  60                  


Arg Leu Glu Trp Val Ala Tyr Ile Ser Ser Gly Gly Ser Gly Thr Tyr 
65                  70                  75                  80  


Tyr Ser Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala 
                85                  90                  95      


Lys Asn Thr Leu Tyr Leu Gln Met Arg Ser Leu Arg Ser Glu Asp Ser 
            100                 105                 110         


Ala Met Tyr Phe Cys Thr Arg Val Lys Leu Gly Thr Tyr Tyr Phe Asp 
        115                 120                 125             


Ser Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr 
145                 150                 155                 160 


Gln Thr Ala Ser Ser Leu Pro Ala Ser Leu Gly Asp Arg Val Thr Ile 
                165                 170                 175     


Ser Cys Ser Ala Ser Gln Asp Ile Ser Asn Tyr Leu Asn Trp Tyr Gln 
            180                 185                 190         


Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile Phe Tyr Ser Ser Asn 
        195                 200                 205             


Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly Gly Gly Ser Gly Thr 
    210                 215                 220                 


Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Pro Glu Asp Ile Ala Thr 
225                 230                 235                 240 


Tyr Phe Cys His Gln Tyr Ser Lys Leu Pro Trp Thr Phe Gly Gly Gly 
                245                 250                 255     


Thr Lys Leu Glu Ile Lys Arg Thr Thr Thr Pro Ala Pro Arg Pro Pro 
            260                 265                 270         


Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu 
        275                 280                 285             


Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp 
    290                 295                 300                 


Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly 
305                 310                 315                 320 


Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Arg Ser Lys Arg 
                325                 330                 335     


Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro 
            340                 345                 350         


Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe 
        355                 360                 365             


Ala Ala Tyr Arg Ser Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro 
    370                 375                 380                 


Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly 
385                 390                 395                 400 


Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro 
                405                 410                 415     


Glu Met Gly Gly Lys Pro Gln Arg Arg Lys Asn Pro Gln Glu Gly Leu 
            420                 425                 430         


Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile 
        435                 440                 445             


Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr 
    450                 455                 460                 


Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met 
465                 470                 475                 480 


Gln Ala Leu Pro Pro Arg Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu 
                485                 490                 495     


Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met Tyr Arg Met 
            500                 505                 510         


Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu Val Thr Asn Ser 
        515                 520                 525             


Gly Ile His Val Phe Ile Leu Gly Cys Phe Ser Ala Gly Leu Pro Lys 
    530                 535                 540                 


Thr Glu Ala Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys Ile Glu 
545                 550                 555                 560 


Asp Leu Ile Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr Glu Ser 
                565                 570                 575     


Asp Val His Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe Leu Leu 
            580                 585                 590         


Glu Leu Gln Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile His Asp 
        595                 600                 605             


Thr Val Glu Asn Leu Ile Ile Leu Ala Asn Asn Ser Leu Ser Ser Asn 
    610                 615                 620                 


Gly Asn Val Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu 
625                 630                 635                 640 


Lys Asn Ile Lys Glu Phe Leu Gln Ser Phe Val His Ile Val Gln Met 
                645                 650                 655     


Phe Ile Asn Thr Ser 
            660     


<210>  244
<211>  2005
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  (GD3-28-2G-IL15xp nucleotide sequence)

<400>  244
gcgatcgcac catggcctta ccagtgaccg ccttgctcct gccgctggcc ttgctgctcc       60

acgccgccag gccggaggtg accctggtgg agagcggcgg cgacttcgtg aagcccggcg      120

gcagcctgaa ggtgagctgc gccgccagcg gcttcgcctt cagccactac gccatgagct      180

gggtgaggca gacccccgcc aagaggctgg agtgggtggc ctacatcagc agcggcggca      240

gcggcaccta ctacagcgac agcgtgaagg gcaggttcac catcagcagg gacaacgcca      300

agaacaccct gtacctgcag atgaggagcc tgaggagcga ggacagcgcc atgtacttct      360

gcaccagggt gaagctgggc acctactact tcgacagctg gggccagggc accaccctga      420

ccgtgagcag cggagggggg ggatccgggg gaggaggctc cggcggaggc ggaagcgaca      480

tccagatgac ccagaccgcc agcagcctgc ccgccagcct gggcgacagg gtgaccatca      540

gctgcagcgc cagccaggac atcagcaact acctgaactg gtaccagcag aagcccgacg      600

gcaccgtgaa gctgctgatc ttctacagca gcaacctgca cagcggcgtg cccagcaggt      660

tcagcggcgg cggcagcggc accgactaca gcctgaccat cagcaacctg gagcccgagg      720

acatcgccac ctacttctgc caccagtaca gcaagctgcc ctggaccttc ggcggcggca      780

ccaagctgga gatcaagagg accacgacgc cagcgccgcg accaccaaca ccggcgccca      840

ccatcgcgtc gcagcccctg tccctgcgcc cagaggcgtg ccggccagcg gcggggggcg      900

cagtgcacac gagggggctg gacttcgcct gtgatatcta catctgggcg cccttggccg      960

ggacttgtgg ggtccttctc ctgtcactgg ttatcaccct ttactgcagg agtaagagga     1020

gcaggctcct gcacagtgac tacatgaaca tgactccccg ccgccccggg cccacccgca     1080

agcattacca gccctatgcc ccaccacgcg acttcgcagc ctatcgctcc agagtgaagt     1140

tcagcaggag cgcagacgcc cccgcgtacc agcagggcca gaaccagctc tataacgagc     1200

tcaatctagg acgaagagag gagtacgatg ttttggacaa gagacgtggc cgggaccctg     1260

agatgggggg aaagccgcag agaaggaaga accctcagga aggcctgtac aatgaactgc     1320

agaaagataa gatggcggag gcctacagtg agattgggat gaaaggcgag cgccggaggg     1380

gcaaggggca cgatggcctt taccagggtc tcagtacagc caccaaggac acctacgacg     1440

cccttcacat gcaggccctg ccccctcgcg gaagcggagc caccaacttc agcctgctga     1500

agcaggccgg cgacgtggag gagaaccccg gccccatgta cagaatgcag ctgctgagct     1560

gcatcgccct gagcctggcc ctggtgacca acagcggcat ccacgtgttc atcctgggct     1620

gcttcagcgc cggcctgccc aagaccgagg ccaactgggt gaacgtgatc agcgacctga     1680

agaagatcga ggacctgatc cagagcatgc acatcgacgc caccctgtac accgagagcg     1740

acgtgcaccc cagctgcaag gtgaccgcca tgaagtgctt cctgctggag ctgcaggtga     1800

tcagcctgga gagcggcgac gccagcatcc acgacaccgt ggagaacctg atcatcctgg     1860

ccaacaacag cctgagcagc aacggcaacg tgaccgagag cggctgcaag gagtgcgagg     1920

agctggagga gaagaacatc aaggagttcc tgcagagctt cgtgcacatc gtgcagatgt     1980

tcatcaacac cagctaagtt taaac                                           2005


<210>  245
<211>  761
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  (GD3-28-41BBL CAR amino acid sequence)

<400>  245

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Val Thr Leu Val Glu Ser Gly Gly Asp Phe 
            20                  25                  30          


Val Lys Pro Gly Gly Ser Leu Lys Val Ser Cys Ala Ala Ser Gly Phe 
        35                  40                  45              


Ala Phe Ser His Tyr Ala Met Ser Trp Val Arg Gln Thr Pro Ala Lys 
    50                  55                  60                  


Arg Leu Glu Trp Val Ala Tyr Ile Ser Ser Gly Gly Ser Gly Thr Tyr 
65                  70                  75                  80  


Tyr Ser Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala 
                85                  90                  95      


Lys Asn Thr Leu Tyr Leu Gln Met Arg Ser Leu Arg Ser Glu Asp Ser 
            100                 105                 110         


Ala Met Tyr Phe Cys Thr Arg Val Lys Leu Gly Thr Tyr Tyr Phe Asp 
        115                 120                 125             


Ser Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr 
145                 150                 155                 160 


Gln Thr Ala Ser Ser Leu Pro Ala Ser Leu Gly Asp Arg Val Thr Ile 
                165                 170                 175     


Ser Cys Ser Ala Ser Gln Asp Ile Ser Asn Tyr Leu Asn Trp Tyr Gln 
            180                 185                 190         


Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile Phe Tyr Ser Ser Asn 
        195                 200                 205             


Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly Gly Gly Ser Gly Thr 
    210                 215                 220                 


Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Pro Glu Asp Ile Ala Thr 
225                 230                 235                 240 


Tyr Phe Cys His Gln Tyr Ser Lys Leu Pro Trp Thr Phe Gly Gly Gly 
                245                 250                 255     


Thr Lys Leu Glu Ile Lys Arg Thr Thr Thr Pro Ala Pro Arg Pro Pro 
            260                 265                 270         


Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu 
        275                 280                 285             


Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp 
    290                 295                 300                 


Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly 
305                 310                 315                 320 


Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Arg Ser Lys Arg 
                325                 330                 335     


Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro 
            340                 345                 350         


Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe 
        355                 360                 365             


Ala Ala Tyr Arg Ser Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro 
    370                 375                 380                 


Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly 
385                 390                 395                 400 


Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro 
                405                 410                 415     


Glu Met Gly Gly Lys Pro Gln Arg Arg Lys Asn Pro Gln Glu Gly Leu 
            420                 425                 430         


Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile 
        435                 440                 445             


Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr 
    450                 455                 460                 


Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met 
465                 470                 475                 480 


Gln Ala Leu Pro Pro Arg Gly Ser Gly Glu Gly Arg Gly Ser Leu Leu 
                485                 490                 495     


Thr Cys Gly Asp Val Glu Glu Asn Pro Gly Pro Met Glu Tyr Ala Ser 
            500                 505                 510         


Asp Ala Ser Leu Asp Pro Glu Ala Pro Trp Pro Pro Ala Pro Arg Ala 
        515                 520                 525             


Arg Ala Cys Arg Val Leu Pro Trp Ala Leu Val Ala Gly Leu Leu Leu 
    530                 535                 540                 


Leu Leu Leu Leu Ala Ala Ala Cys Ala Val Phe Leu Ala Cys Pro Trp 
545                 550                 555                 560 


Ala Val Ser Gly Ala Arg Ala Ser Pro Gly Ser Ala Ala Ser Pro Arg 
                565                 570                 575     


Leu Arg Glu Gly Pro Glu Leu Ser Pro Asp Asp Pro Ala Gly Leu Leu 
            580                 585                 590         


Asp Leu Arg Gln Gly Met Phe Ala Gln Leu Val Ala Gln Asn Val Leu 
        595                 600                 605             


Leu Ile Asp Gly Pro Leu Ser Trp Tyr Ser Asp Pro Gly Leu Ala Gly 
    610                 615                 620                 


Val Ser Leu Thr Gly Gly Leu Ser Tyr Lys Glu Asp Thr Lys Glu Leu 
625                 630                 635                 640 


Val Val Ala Lys Ala Gly Val Tyr Tyr Val Phe Phe Gln Leu Glu Leu 
                645                 650                 655     


Arg Arg Val Val Ala Gly Glu Gly Ser Gly Ser Val Ser Leu Ala Leu 
            660                 665                 670         


His Leu Gln Pro Leu Arg Ser Ala Ala Gly Ala Ala Ala Leu Ala Leu 
        675                 680                 685             


Thr Val Asp Leu Pro Pro Ala Ser Ser Glu Ala Arg Asn Ser Ala Phe 
    690                 695                 700                 


Gly Phe Gln Gly Arg Leu Leu His Leu Ser Ala Gly Gln Arg Leu Gly 
705                 710                 715                 720 


Val His Leu His Thr Glu Ala Arg Ala Arg His Ala Trp Gln Leu Thr 
                725                 730                 735     


Gln Gly Ala Thr Val Leu Gly Leu Phe Arg Val Thr Pro Glu Ile Pro 
            740                 745                 750         


Ala Gly Leu Pro Ser Pro Arg Ser Glu 
        755                 760     


<210>  246
<211>  2305
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  (GD3-28-41BBL nucleotide sequence)

<400>  246
gcgatcgcac catggcctta ccagtgaccg ccttgctcct gccgctggcc ttgctgctcc       60

acgccgccag gccggaggtg accctggtgg agagcggcgg cgacttcgtg aagcccggcg      120

gcagcctgaa ggtgagctgc gccgccagcg gcttcgcctt cagccactac gccatgagct      180

gggtgaggca gacccccgcc aagaggctgg agtgggtggc ctacatcagc agcggcggca      240

gcggcaccta ctacagcgac agcgtgaagg gcaggttcac catcagcagg gacaacgcca      300

agaacaccct gtacctgcag atgaggagcc tgaggagcga ggacagcgcc atgtacttct      360

gcaccagggt gaagctgggc acctactact tcgacagctg gggccagggc accaccctga      420

ccgtgagcag cggagggggg ggatccgggg gaggaggctc cggcggaggc ggaagcgaca      480

tccagatgac ccagaccgcc agcagcctgc ccgccagcct gggcgacagg gtgaccatca      540

gctgcagcgc cagccaggac atcagcaact acctgaactg gtaccagcag aagcccgacg      600

gcaccgtgaa gctgctgatc ttctacagca gcaacctgca cagcggcgtg cccagcaggt      660

tcagcggcgg cggcagcggc accgactaca gcctgaccat cagcaacctg gagcccgagg      720

acatcgccac ctacttctgc caccagtaca gcaagctgcc ctggaccttc ggcggcggca      780

ccaagctgga gatcaagagg accacgacgc cagcgccgcg accaccaaca ccggcgccca      840

ccatcgcgtc gcagcccctg tccctgcgcc cagaggcgtg ccggccagcg gcggggggcg      900

cagtgcacac gagggggctg gacttcgcct gtgatatcta catctgggcg cccttggccg      960

ggacttgtgg ggtccttctc ctgtcactgg ttatcaccct ttactgcagg agtaagagga     1020

gcaggctcct gcacagtgac tacatgaaca tgactccccg ccgccccggg cccacccgca     1080

agcattacca gccctatgcc ccaccacgcg acttcgcagc ctatcgctcc agagtgaagt     1140

tcagcaggag cgcagacgcc cccgcgtacc agcagggcca gaaccagctc tataacgagc     1200

tcaatctagg acgaagagag gagtacgatg ttttggacaa gagacgtggc cgggaccctg     1260

agatgggggg aaagccgcag agaaggaaga accctcagga aggcctgtac aatgaactgc     1320

agaaagataa gatggcggag gcctacagtg agattgggat gaaaggcgag cgccggaggg     1380

gcaaggggca cgatggcctt taccagggtc tcagtacagc caccaaggac acctacgacg     1440

cccttcacat gcaggccctg ccccctcgcg gcagcggcga aggccgcggc agcctgctga     1500

cctgcggcga tgtggaagaa aacccgggcc ccatggaata cgcctctgac gcttcactgg     1560

accccgaagc cccgtggcct cccgcgcccc gcgctcgcgc ctgccgcgta ctgccttggg     1620

ccctggtcgc ggggctgctg ctgctgctgc tgctcgctgc cgcctgcgcc gtcttcctcg     1680

cctgcccctg ggccgtgtcc ggggctcgcg cctcgcccgg ctccgcggcc agcccgagac     1740

tccgcgaggg tcccgagctt tcgcccgacg atcccgccgg cctcttggac ctgcggcagg     1800

gcatgtttgc gcagctggtg gcccaaaatg ttctgctgat cgatgggccc ctgagctggt     1860

acagtgaccc aggcctggca ggcgtgtccc tgacgggggg cctgagctac aaagaggaca     1920

cgaaggagct ggtggtggcc aaggctggag tctactatgt cttctttcaa ctagagctgc     1980

ggcgcgtggt ggccggcgag ggctcaggct ccgtttcact tgcgctgcac ctgcagccac     2040

tgcgctctgc tgctggggcc gccgccctgg ctttgaccgt ggacctgcca cccgcctcct     2100

ccgaggctcg gaactcggcc ttcggtttcc agggccgctt gctgcacctg agtgccggcc     2160

agcgcctggg cgtccatctt cacactgagg ccagggcacg ccatgcctgg cagcttaccc     2220

agggcgccac agtcttggga ctcttccggg tgacccccga aatcccagcc ggactccctt     2280

caccgaggtc ggaataagtt taaac                                           2305


<210>  247
<211>  819
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  (GD3-28-IL15/IL-15sushi anchor CAR amino acid sequence)

<400>  247

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Val Thr Leu Val Glu Ser Gly Gly Asp Phe 
            20                  25                  30          


Val Lys Pro Gly Gly Ser Leu Lys Val Ser Cys Ala Ala Ser Gly Phe 
        35                  40                  45              


Ala Phe Ser His Tyr Ala Met Ser Trp Val Arg Gln Thr Pro Ala Lys 
    50                  55                  60                  


Arg Leu Glu Trp Val Ala Tyr Ile Ser Ser Gly Gly Ser Gly Thr Tyr 
65                  70                  75                  80  


Tyr Ser Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala 
                85                  90                  95      


Lys Asn Thr Leu Tyr Leu Gln Met Arg Ser Leu Arg Ser Glu Asp Ser 
            100                 105                 110         


Ala Met Tyr Phe Cys Thr Arg Val Lys Leu Gly Thr Tyr Tyr Phe Asp 
        115                 120                 125             


Ser Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr 
145                 150                 155                 160 


Gln Thr Ala Ser Ser Leu Pro Ala Ser Leu Gly Asp Arg Val Thr Ile 
                165                 170                 175     


Ser Cys Ser Ala Ser Gln Asp Ile Ser Asn Tyr Leu Asn Trp Tyr Gln 
            180                 185                 190         


Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile Phe Tyr Ser Ser Asn 
        195                 200                 205             


Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly Gly Gly Ser Gly Thr 
    210                 215                 220                 


Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Pro Glu Asp Ile Ala Thr 
225                 230                 235                 240 


Tyr Phe Cys His Gln Tyr Ser Lys Leu Pro Trp Thr Phe Gly Gly Gly 
                245                 250                 255     


Thr Lys Leu Glu Ile Lys Arg Thr Thr Thr Pro Ala Pro Arg Pro Pro 
            260                 265                 270         


Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu 
        275                 280                 285             


Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp 
    290                 295                 300                 


Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly 
305                 310                 315                 320 


Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Arg Ser Lys Arg 
                325                 330                 335     


Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro 
            340                 345                 350         


Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe 
        355                 360                 365             


Ala Ala Tyr Arg Ser Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro 
    370                 375                 380                 


Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly 
385                 390                 395                 400 


Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro 
                405                 410                 415     


Glu Met Gly Gly Lys Pro Gln Arg Arg Lys Asn Pro Gln Glu Gly Leu 
            420                 425                 430         


Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile 
        435                 440                 445             


Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr 
    450                 455                 460                 


Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met 
465                 470                 475                 480 


Gln Ala Leu Pro Pro Arg Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu 
                485                 490                 495     


Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met Tyr Arg Met 
            500                 505                 510         


Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu Val Thr Asn Ser 
        515                 520                 525             


Gly Ile His Val Phe Ile Leu Gly Cys Phe Ser Ala Gly Leu Pro Lys 
    530                 535                 540                 


Thr Glu Ala Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys Ile Glu 
545                 550                 555                 560 


Asp Leu Ile Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr Glu Ser 
                565                 570                 575     


Asp Val His Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe Leu Leu 
            580                 585                 590         


Glu Leu Gln Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile His Asp 
        595                 600                 605             


Thr Val Glu Asn Leu Ile Ile Leu Ala Asn Asn Ser Leu Ser Ser Asn 
    610                 615                 620                 


Gly Asn Val Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu 
625                 630                 635                 640 


Lys Asn Ile Lys Glu Phe Leu Gln Ser Phe Val His Ile Val Gln Met 
                645                 650                 655     


Phe Ile Asn Thr Ser Ser Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
            660                 665                 670         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Leu Gln Ile 
        675                 680                 685             


Thr Cys Pro Pro Pro Met Ser Val Glu His Ala Asp Ile Trp Val Lys 
    690                 695                 700                 


Ser Tyr Ser Leu Tyr Ser Arg Glu Arg Tyr Ile Cys Asn Ser Gly Phe 
705                 710                 715                 720 


Lys Arg Lys Ala Gly Thr Ser Ser Leu Thr Glu Cys Val Leu Asn Lys 
                725                 730                 735     


Ala Thr Asn Val Ala His Trp Thr Thr Pro Ser Leu Lys Cys Ile Arg 
            740                 745                 750         


Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala 
        755                 760                 765             


Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly 
    770                 775                 780                 


Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Val Ala Ile 
785                 790                 795                 800 


Ser Thr Ser Thr Val Leu Leu Cys Gly Leu Ser Ala Val Ser Leu Leu 
                805                 810                 815     


Ala Cys Tyr 
            


<210>  248
<211>  2479
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  (GD3-28-IL15/IL-15sushi anchor nucleotide sequence)

<400>  248
gcgatcgcac catggcctta ccagtgaccg ccttgctcct gccgctggcc ttgctgctcc       60

acgccgccag gccggaggtg accctggtgg agagcggcgg cgacttcgtg aagcccggcg      120

gcagcctgaa ggtgagctgc gccgccagcg gcttcgcctt cagccactac gccatgagct      180

gggtgaggca gacccccgcc aagaggctgg agtgggtggc ctacatcagc agcggcggca      240

gcggcaccta ctacagcgac agcgtgaagg gcaggttcac catcagcagg gacaacgcca      300

agaacaccct gtacctgcag atgaggagcc tgaggagcga ggacagcgcc atgtacttct      360

gcaccagggt gaagctgggc acctactact tcgacagctg gggccagggc accaccctga      420

ccgtgagcag cggagggggg ggatccgggg gaggaggctc cggcggaggc ggaagcgaca      480

tccagatgac ccagaccgcc agcagcctgc ccgccagcct gggcgacagg gtgaccatca      540

gctgcagcgc cagccaggac atcagcaact acctgaactg gtaccagcag aagcccgacg      600

gcaccgtgaa gctgctgatc ttctacagca gcaacctgca cagcggcgtg cccagcaggt      660

tcagcggcgg cggcagcggc accgactaca gcctgaccat cagcaacctg gagcccgagg      720

acatcgccac ctacttctgc caccagtaca gcaagctgcc ctggaccttc ggcggcggca      780

ccaagctgga gatcaagagg accacgacgc cagcgccgcg accaccaaca ccggcgccca      840

ccatcgcgtc gcagcccctg tccctgcgcc cagaggcgtg ccggccagcg gcggggggcg      900

cagtgcacac gagggggctg gacttcgcct gtgatatcta catctgggcg cccttggccg      960

ggacttgtgg ggtccttctc ctgtcactgg ttatcaccct ttactgcagg agtaagagga     1020

gcaggctcct gcacagtgac tacatgaaca tgactccccg ccgccccggg cccacccgca     1080

agcattacca gccctatgcc ccaccacgcg acttcgcagc ctatcgctcc agagtgaagt     1140

tcagcaggag cgcagacgcc cccgcgtacc agcagggcca gaaccagctc tataacgagc     1200

tcaatctagg acgaagagag gagtacgatg ttttggacaa gagacgtggc cgggaccctg     1260

agatgggggg aaagccgcag agaaggaaga accctcagga aggcctgtac aatgaactgc     1320

agaaagataa gatggcggag gcctacagtg agattgggat gaaaggcgag cgccggaggg     1380

gcaaggggca cgatggcctt taccagggtc tcagtacagc caccaaggac acctacgacg     1440

cccttcacat gcaggccctg ccccctcgcg gaagcggagc caccaacttc agcctgctga     1500

agcaggccgg cgacgtggag gagaaccccg gccccatgta cagaatgcag ctgctgagct     1560

gcatcgccct gagcctggcc ctggtgacca acagcggcat ccacgtgttc atcctgggct     1620

gcttcagcgc cggcctgccc aagaccgagg ccaactgggt gaacgtgatc agcgacctga     1680

agaagatcga ggacctgatc cagagcatgc acatcgacgc caccctgtac accgagagcg     1740

acgtgcaccc cagctgcaag gtgaccgcca tgaagtgctt cctgctggag ctgcaggtga     1800

tcagcctgga gagcggcgac gccagcatcc acgacaccgt ggagaacctg atcatcctgg     1860

ccaacaacag cctgagcagc aacggcaacg tgaccgagag cggctgcaag gagtgcgagg     1920

agctggagga gaagaacatc aaggagttcc tgcagagctt cgtgcacatc gtgcagatgt     1980

tcatcaacac cagctccggc ggcggctccg gcggcggcgg ctccggcggc ggcggctccg     2040

gcggcggcgg ctccggcggc ggctccctgc agatcacctg cccccccccc atgagcgtgg     2100

agcacgccga catctgggtg aagagctaca gcctgtacag cagagagaga tacatctgca     2160

acagcggctt caagagaaag gccggcacca gcagcctgac cgagtgcgtg ctgaacaagg     2220

ccaccaacgt ggcccactgg accaccccca gcctgaagtg catcagaacc accacccccg     2280

cccccaggcc ccccaccccc gcccccacca tcgccagcca gcccctgagc ctgaggcccg     2340

aggcctgcag gcccgccgcc ggcggcgccg tgcacaccag gggcctggac ttcgcctgcg     2400

acgtggctat ctccacgtcc actgtcctgc tgtgtgggct gagcgctgtg tctctcctgg     2460

catgctacta agtttaaac                                                  2479


<210>  249
<211>  780
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  (GD3-28-IL15/IL-15sushi CAR amino acid sequence)

<400>  249

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Val Thr Leu Val Glu Ser Gly Gly Asp Phe 
            20                  25                  30          


Val Lys Pro Gly Gly Ser Leu Lys Val Ser Cys Ala Ala Ser Gly Phe 
        35                  40                  45              


Ala Phe Ser His Tyr Ala Met Ser Trp Val Arg Gln Thr Pro Ala Lys 
    50                  55                  60                  


Arg Leu Glu Trp Val Ala Tyr Ile Ser Ser Gly Gly Ser Gly Thr Tyr 
65                  70                  75                  80  


Tyr Ser Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala 
                85                  90                  95      


Lys Asn Thr Leu Tyr Leu Gln Met Arg Ser Leu Arg Ser Glu Asp Ser 
            100                 105                 110         


Ala Met Tyr Phe Cys Thr Arg Val Lys Leu Gly Thr Tyr Tyr Phe Asp 
        115                 120                 125             


Ser Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr 
145                 150                 155                 160 


Gln Thr Ala Ser Ser Leu Pro Ala Ser Leu Gly Asp Arg Val Thr Ile 
                165                 170                 175     


Ser Cys Ser Ala Ser Gln Asp Ile Ser Asn Tyr Leu Asn Trp Tyr Gln 
            180                 185                 190         


Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile Phe Tyr Ser Ser Asn 
        195                 200                 205             


Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly Gly Gly Ser Gly Thr 
    210                 215                 220                 


Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Pro Glu Asp Ile Ala Thr 
225                 230                 235                 240 


Tyr Phe Cys His Gln Tyr Ser Lys Leu Pro Trp Thr Phe Gly Gly Gly 
                245                 250                 255     


Thr Lys Leu Glu Ile Lys Arg Thr Thr Thr Pro Ala Pro Arg Pro Pro 
            260                 265                 270         


Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu 
        275                 280                 285             


Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp 
    290                 295                 300                 


Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly 
305                 310                 315                 320 


Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Arg Ser Lys Arg 
                325                 330                 335     


Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro 
            340                 345                 350         


Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe 
        355                 360                 365             


Ala Ala Tyr Arg Ser Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro 
    370                 375                 380                 


Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly 
385                 390                 395                 400 


Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro 
                405                 410                 415     


Glu Met Gly Gly Lys Pro Gln Arg Arg Lys Asn Pro Gln Glu Gly Leu 
            420                 425                 430         


Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile 
        435                 440                 445             


Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr 
    450                 455                 460                 


Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met 
465                 470                 475                 480 


Gln Ala Leu Pro Pro Arg Gly Ser Gly Glu Gly Arg Gly Ser Leu Leu 
                485                 490                 495     


Thr Cys Gly Asp Val Glu Glu Asn Pro Gly Pro Met Tyr Arg Met Gln 
            500                 505                 510         


Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu Val Thr Asn Ser Gly 
        515                 520                 525             


Ile His Val Phe Ile Leu Gly Cys Phe Ser Ala Gly Leu Pro Lys Thr 
    530                 535                 540                 


Glu Ala Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys Ile Glu Asp 
545                 550                 555                 560 


Leu Ile Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr Glu Ser Asp 
                565                 570                 575     


Val His Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe Leu Leu Glu 
            580                 585                 590         


Leu Gln Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile His Asp Thr 
        595                 600                 605             


Val Glu Asn Leu Ile Ile Leu Ala Asn Asn Ser Leu Ser Ser Asn Gly 
    610                 615                 620                 


Asn Val Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu Lys 
625                 630                 635                 640 


Asn Ile Lys Glu Phe Leu Gln Ser Phe Val His Ile Val Gln Met Phe 
                645                 650                 655     


Ile Asn Thr Ser Ser Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
            660                 665                 670         


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Leu Gln Ala Pro 
        675                 680                 685             


Arg Arg Ala Arg Gly Cys Arg Thr Leu Gly Leu Pro Ala Leu Leu Leu 
    690                 695                 700                 


Leu Leu Leu Leu Arg Pro Pro Ala Thr Arg Gly Ile Thr Cys Pro Pro 
705                 710                 715                 720 


Pro Met Ser Val Glu His Ala Asp Ile Trp Val Lys Ser Tyr Ser Leu 
                725                 730                 735     


Tyr Ser Arg Glu Arg Tyr Ile Cys Asn Ser Gly Phe Lys Arg Lys Ala 
            740                 745                 750         


Gly Thr Ser Ser Leu Thr Glu Cys Val Leu Asn Lys Ala Thr Asn Val 
        755                 760                 765             


Ala His Trp Thr Thr Pro Ser Leu Lys Cys Ile Arg 
    770                 775                 780 


<210>  250
<211>  2362
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  (GD3-28-IL15/IL-15sushi CAR nucleotide sequence)

<400>  250
gcgatcgcac catggcctta ccagtgaccg ccttgctcct gccgctggcc ttgctgctcc       60

acgccgccag gccggaggtg accctggtgg agagcggcgg cgacttcgtg aagcccggcg      120

gcagcctgaa ggtgagctgc gccgccagcg gcttcgcctt cagccactac gccatgagct      180

gggtgaggca gacccccgcc aagaggctgg agtgggtggc ctacatcagc agcggcggca      240

gcggcaccta ctacagcgac agcgtgaagg gcaggttcac catcagcagg gacaacgcca      300

agaacaccct gtacctgcag atgaggagcc tgaggagcga ggacagcgcc atgtacttct      360

gcaccagggt gaagctgggc acctactact tcgacagctg gggccagggc accaccctga      420

ccgtgagcag cggagggggg ggatccgggg gaggaggctc cggcggaggc ggaagcgaca      480

tccagatgac ccagaccgcc agcagcctgc ccgccagcct gggcgacagg gtgaccatca      540

gctgcagcgc cagccaggac atcagcaact acctgaactg gtaccagcag aagcccgacg      600

gcaccgtgaa gctgctgatc ttctacagca gcaacctgca cagcggcgtg cccagcaggt      660

tcagcggcgg cggcagcggc accgactaca gcctgaccat cagcaacctg gagcccgagg      720

acatcgccac ctacttctgc caccagtaca gcaagctgcc ctggaccttc ggcggcggca      780

ccaagctgga gatcaagagg accacgacgc cagcgccgcg accaccaaca ccggcgccca      840

ccatcgcgtc gcagcccctg tccctgcgcc cagaggcgtg ccggccagcg gcggggggcg      900

cagtgcacac gagggggctg gacttcgcct gtgatatcta catctgggcg cccttggccg      960

ggacttgtgg ggtccttctc ctgtcactgg ttatcaccct ttactgcagg agtaagagga     1020

gcaggctcct gcacagtgac tacatgaaca tgactccccg ccgccccggg cccacccgca     1080

agcattacca gccctatgcc ccaccacgcg acttcgcagc ctatcgctcc agagtgaagt     1140

tcagcaggag cgcagacgcc cccgcgtacc agcagggcca gaaccagctc tataacgagc     1200

tcaatctagg acgaagagag gagtacgatg ttttggacaa gagacgtggc cgggaccctg     1260

agatgggggg aaagccgcag agaaggaaga accctcagga aggcctgtac aatgaactgc     1320

agaaagataa gatggcggag gcctacagtg agattgggat gaaaggcgag cgccggaggg     1380

gcaaggggca cgatggcctt taccagggtc tcagtacagc caccaaggac acctacgacg     1440

cccttcacat gcaggccctg ccccctcgcg gcagcggcga aggccgcggc agcctgctga     1500

cctgcggcga tgtggaagaa aacccgggcc ccatgtacag aatgcagctg ctgagctgca     1560

tcgccctgag cctggccctg gtgaccaaca gcggcatcca cgtgttcatc ctgggctgct     1620

tcagcgccgg cctgcccaag accgaggcca actgggtgaa cgtgatcagc gacctgaaga     1680

agatcgagga cctgatccag agcatgcaca tcgacgccac cctgtacacc gagagcgacg     1740

tgcaccccag ctgcaaggtg accgccatga agtgcttcct gctggagctg caggtgatca     1800

gcctggagag cggcgacgcc agcatccacg acaccgtgga gaacctgatc atcctggcca     1860

acaacagcct gagcagcaac ggcaacgtga ccgagagcgg ctgcaaggag tgcgaggagc     1920

tggaggagaa gaacatcaag gagttcctgc agagcttcgt gcacatcgtg cagatgttca     1980

tcaacaccag ctccggcggc ggctccggcg gcggcggctc cggcggcggc ggctccggcg     2040

gcggcggctc cggcggcggc tccctgcagg cccccagaag agccagaggc tgcagaaccc     2100

tgggcctgcc cgccctgctg ctgctgctgc tgctgagacc ccccgccacc agaggcatca     2160

cctgcccccc ccccatgagc gtggagcacg ccgacatctg ggtgaagagc tacagcctgt     2220

acagcagaga gagatacatc tgcaacagcg gcttcaagag aaaggccggc accagcagcc     2280

tgaccgagtg cgtgctgaac aaggccacca acgtggccca ctggaccacc cccagcctga     2340

agtgcatcag ataagtttaa ac                                              2362


<210>  251
<211>  1004
<212>  PRT
<213>  Artificial Sequence

<220>
<223>   (BCMA-A7D-CD19b-BBpre-2G CAR amino acid sequence)

<400>  251

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Asp Val Val Met Thr Gln Ser His Arg Phe Met 
            20                  25                  30          


Ser Thr Ser Val Gly Asp Arg Val Ser Ile Thr Cys Arg Ala Ser Gln 
        35                  40                  45              


Asp Val Asn Thr Ala Val Ser Trp Tyr Gln Gln Lys Pro Gly Gln Ser 
    50                  55                  60                  


Pro Lys Leu Leu Ile Phe Ser Ala Ser Tyr Arg Tyr Thr Gly Val Pro 
65                  70                  75                  80  


Asp Arg Phe Thr Gly Ser Gly Ser Gly Ala Asp Phe Thr Leu Thr Ile 
                85                  90                  95      


Ser Ser Val Gln Ala Glu Asp Leu Ala Val Tyr Tyr Cys Gln Gln His 
            100                 105                 110         


Tyr Ser Thr Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Asp Ile Lys 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln 
    130                 135                 140                 


Ile Gln Leu Val Gln Ser Gly Pro Asp Leu Lys Lys Pro Gly Glu Thr 
145                 150                 155                 160 


Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Phe Gly 
                165                 170                 175     


Met Asn Trp Val Lys Gln Ala Pro Gly Lys Gly Phe Lys Trp Met Ala 
            180                 185                 190         


Trp Ile Asn Thr Tyr Thr Gly Glu Ser Tyr Phe Ala Asp Asp Phe Lys 
        195                 200                 205             


Gly Arg Phe Ala Phe Ser Val Glu Thr Ser Ala Thr Thr Ala Tyr Leu 
    210                 215                 220                 


Gln Ile Asn Asn Leu Lys Thr Glu Asp Thr Ala Thr Tyr Phe Cys Ala 
225                 230                 235                 240 


Arg Gly Glu Ile Tyr Tyr Gly Tyr Asp Gly Gly Phe Ala Tyr Trp Gly 
                245                 250                 255     


Gln Gly Thr Leu Val Thr Val Ser Ala Thr Thr Thr Pro Ala Pro Arg 
            260                 265                 270         


Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg 
        275                 280                 285             


Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly 
    290                 295                 300                 


Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr 
305                 310                 315                 320 


Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Arg Ser 
                325                 330                 335     


Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg 
            340                 345                 350         


Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg 
        355                 360                 365             


Asp Phe Ala Ala Tyr Arg Ser Arg Val Lys Phe Ser Arg Ser Ala Asp 
    370                 375                 380                 


Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn 
385                 390                 395                 400 


Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg 
                405                 410                 415     


Asp Pro Glu Met Gly Gly Lys Pro Gln Arg Arg Lys Asn Pro Gln Glu 
            420                 425                 430         


Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser 
        435                 440                 445             


Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly 
    450                 455                 460                 


Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu 
465                 470                 475                 480 


His Met Gln Ala Leu Pro Pro Arg Gly Ser Gly Ala Thr Asn Phe Ser 
                485                 490                 495     


Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met Ala 
            500                 505                 510         


Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu His Ala 
        515                 520                 525             


Ala Arg Pro Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Ile Lys 
    530                 535                 540                 


Pro Gly Ala Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
545                 550                 555                 560 


Thr Ser Tyr Val Met His Trp Val Lys Gln Lys Pro Gly Gln Gly Leu 
                565                 570                 575     


Glu Trp Ile Gly Tyr Ile Asn Pro Tyr Asn Asp Gly Thr Lys Tyr Asn 
            580                 585                 590         


Glu Lys Phe Lys Gly Lys Ala Thr Leu Thr Ser Asp Lys Ser Ser Ser 
        595                 600                 605             


Thr Ala Tyr Met Glu Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val 
    610                 615                 620                 


Tyr Tyr Cys Ala Arg Gly Thr Tyr Tyr Tyr Gly Ser Arg Val Phe Asp 
625                 630                 635                 640 


Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser Gly Gly Gly Gly 
                645                 650                 655     


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val Met Thr 
            660                 665                 670         


Gln Ala Ala Pro Ser Ile Pro Val Thr Pro Gly Glu Ser Val Ser Ile 
        675                 680                 685             


Ser Cys Arg Ser Ser Lys Ser Leu Leu Asn Ser Asn Gly Asn Thr Tyr 
    690                 695                 700                 


Leu Tyr Trp Phe Leu Gln Arg Pro Gly Gln Ser Pro Gln Leu Leu Ile 
705                 710                 715                 720 


Tyr Arg Met Ser Asn Leu Ala Ser Gly Val Pro Asp Arg Phe Ser Gly 
                725                 730                 735     


Ser Gly Ser Gly Thr Ala Phe Thr Leu Arg Ile Ser Arg Val Glu Ala 
            740                 745                 750         


Glu Asp Val Gly Val Tyr Tyr Cys Met Gln His Leu Glu Tyr Pro Phe 
        755                 760                 765             


Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Arg Thr Thr Thr Pro 
    770                 775                 780                 


Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu 
785                 790                 795                 800 


Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His 
                805                 810                 815     


Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu 
            820                 825                 830         


Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr 
        835                 840                 845             


Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe 
    850                 855                 860                 


Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg 
865                 870                 875                 880 


Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser 
                885                 890                 895     


Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr 
            900                 905                 910         


Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys 
        915                 920                 925             


Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Gln Arg Arg Lys 
    930                 935                 940                 


Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala 
945                 950                 955                 960 


Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys 
                965                 970                 975     


Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr 
            980                 985                 990         


Tyr Asp Ala Leu His Met Gln Ala  Leu Pro Pro Arg 
        995                 1000                 


<210>  252
<211>  3023
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  (BCMA-A7D-CD19b-BBpre-2G CAR amino acid sequence)

<400>  252
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccggacgtgg tgatgaccca gagccacagg ttcatgagca ccagcgtggg cgacagggtg      120

agcatcacct gcagggccag ccaggacgtg aacaccgccg tgagctggta ccagcagaag      180

cccggccaga gccccaagct gctgatcttc agcgccagct acaggtacac cggcgtgccc      240

gacaggttca ccggcagcgg cagcggcgcc gacttcaccc tgaccatcag cagcgtgcag      300

gccgaggacc tggccgtgta ctactgccag cagcactaca gcaccccctg gaccttcggc      360

ggcggcacca agctggacat caagggaggg gggggatccg ggggaggagg ctccggcgga      420

ggcggaagcc agatccagct ggtgcagagc ggccccgacc tgaagaagcc cggcgagacc      480

gtgaagctga gctgcaaggc cagcggctac accttcacca acttcggcat gaactgggtg      540

aagcaggccc ccggcaaggg cttcaagtgg atggcctgga tcaacaccta caccggcgag      600

agctacttcg ccgacgactt caagggcagg ttcgccttca gcgtggagac cagcgccacc      660

accgcctacc tgcagatcaa caacctgaag accgaggaca ccgccaccta cttctgcgcc      720

aggggcgaga tctactacgg ctacgacggc ggcttcgcct actggggcca gggcaccctg      780

gtgaccgtga gcgccaccac gacgccagcg ccgcgaccac caacaccggc gcccaccatc      840

gcgtcgcagc ccctgtccct gcgcccagag gcgtgccggc cagcggcggg gggcgcagtg      900

cacacgaggg ggctggactt cgcctgtgat atctacatct gggcgccctt ggccgggact      960

tgtggggtcc ttctcctgtc actggttatc accctttact gcaggagtaa gaggagcagg     1020

ctcctgcaca gtgactacat gaacatgact ccccgccgcc ccgggcccac ccgcaagcat     1080

taccagccct atgccccacc acgcgacttc gcagcctatc gctccagagt gaagttcagc     1140

aggagcgcag acgcccccgc gtaccagcag ggccagaacc agctctataa cgagctcaat     1200

ctaggacgaa gagaggagta cgatgttttg gacaagagac gtggccggga ccctgagatg     1260

gggggaaagc cgcagagaag gaagaaccct caggaaggcc tgtacaatga actgcagaaa     1320

gataagatgg cggaggccta cagtgagatt gggatgaaag gcgagcgccg gaggggcaag     1380

gggcacgatg gcctttacca gggtctcagt acagccacca aggacaccta cgacgccctt     1440

cacatgcagg ccctgccccc tcgcggaagc ggagccacca acttcagcct gctgaagcag     1500

gccggcgacg tggaggagaa ccccggcccc atggccctgc ccgtgaccgc cctgctgctg     1560

cccctggccc tgctgctgca cgccgccagg cccgaggtcc agctgcagca gtctggacct     1620

gagctgataa agcctggggc ttcagtgaag atgtcctgca aggcttctgg atacacattc     1680

actagctatg ttatgcactg ggtgaagcag aagcctgggc agggccttga gtggattgga     1740

tatattaatc cttacaatga tggtactaag tacaatgaga agttcaaagg caaggccaca     1800

ctgacttcag acaaatcctc cagcacagcc tacatggagc tcagcagcct gacctctgag     1860

gactctgcgg tctattactg tgcaagaggg acttattact acggtagtag ggtatttgac     1920

tactggggcc aaggcaccac tctcacagtc tcctcaggtg gagggggctc aggcggaggt     1980

ggctctgggg gtggaggctc ggacattgtg atgactcagg ctgcaccctc tatacctgtc     2040

actcctggag agtcagtatc catctcctgc aggtctagta agagtctcct gaatagtaat     2100

ggcaacactt acttgtattg gttcctgcag aggccaggcc agtctcctca gctcctgata     2160

tatcggatgt ccaaccttgc ctcaggagtc ccagacaggt tcagtggcag tgggtcagga     2220

actgctttca cactgagaat cagtagagtg gaggctgagg atgtgggtgt ttattactgt     2280

atgcaacatc tagaatatcc gttcacgttc ggtgctggga ccaagctgga gctgaaacgg     2340

accaccaccc ccgcccccag gccccccacc cccgccccca ccatcgccag ccagcccctg     2400

agcctgaggc ccgaggcctg caggcccgcc gccggcggcg ccgtgcacac caggggcctg     2460

gacttcgcct gcgacatcta catctgggcc cccctggccg gcacctgcgg cgtgctgctg     2520

ctgagcctgg tgatcaccct gtactgcaaa cggggcagaa agaaactcct gtatatattc     2580

aaacaaccat ttatgagacc agtacaaact actcaagagg aagatggctg tagctgccga     2640

tttccagaag aagaagaagg aggatgtgaa ctgagggtga agttcagcag gagcgccgac     2700

gcccccgcct accagcaggg ccagaaccag ctgtacaacg agctgaacct gggcaggagg     2760

gaggagtacg acgtgctgga caagaggagg ggcagggacc ccgagatggg cggcaagccc     2820

cagaggagga agaaccccca ggagggcctg tacaacgagc tgcagaagga caagatggcc     2880

gaggcctaca gcgagatcgg catgaagggc gagaggagga ggggcaaggg ccacgacggc     2940

ctgtaccagg gcctgagcac cgccaccaag gacacctacg acgccctgca catgcaggcc     3000

ctgcccccca ggtaagttta aac                                             3023


