                         SEQUENCE LISTING

<110>  Dana-Farber Cancer Institute, Inc.
 
<120>  Methods For Modulating Regulatory T Cells, Regulatory B Cells, 
       And Immune Responses Using Modulators Of The APRIL-TACI 
       Interaction

<130>  DFS-194.25

<140>  PCT/US2018/038490
<141>  2018-06-20

<150>  US 62/677,265
<151>  2018-05-29

<150>  US 62/573,264
<151>  2017-10-17

<150>  US 62/522,167
<151>  2017-06-20

<160>  24    

<170>  PatentIn version 3.5

<210>  1
<211>  2293
<212>  DNA
<213>  Homo sapiens

<400>  1
ccggaaccct gtgtgctggg gaggaatccc gcagtggccg gggggcttga ggccgctgct       60

ttgtctcttc gtccagagcc ttatgtaaga gcttttctcg ggaaacagga agtcctgctt      120

gccaatttca gcacagggag tagtgcaggc cttattccaa cacacccggc ccagccttaa      180

ccccagaact cagccagttt cttgcttccg tgcccctggt tctcctcccc atcgagccca      240

cccctccttt cccaccttca gtcaccccta gtgaactgcc ccagcgatct ctgctgtgct      300

tgaccccgag ggtcttccac cctcgccctg accctggaca ctgcccagct tggcccccca      360

tcctgctcct ggcacaatgc cctctagcca gccaaccttc cctcccccaa ccctggggcc      420

gccccagggt tcctgcgcac tgcctgttcc tcctgggtgt cactggcagc cctgtccttc      480

ctagagggac tggaacctaa ttctcctgag gctgagggag ggtggagggt ctcaaggcaa      540

cgctggcccc acgacggagt gccaggagca ctaacagtac ccttagcttg ctttcctcct      600

ccctcctttt tattttcaag ttccttttta tttctccttg cgtaacaacc ttcttccctt      660

ctgcaccact gcccgtaccc ttacccgccc cgccacctcc ttgctacccc actcttgaaa      720

ccacagctgt tggcagggtc cccagctcat gccagcctca tctcctttct tgctagcccc      780

caaagggcct ccaggcaaca tggggggccc agtcagagag ccggcactct cagttgccct      840

ctggttgagt tggggggcag ctctgggggc cgtggcttgt gccatggctc tgctgaccca      900

acaaacagag ctgcagagcc tcaggagaga ggtgagccgg ctgcagggga caggaggccc      960

ctcccagaat ggggaagggt atccctggca gagtctcccg gagcagagtt ccgatgccct     1020

ggaagcctgg gagaatgggg agagatcccg gaaaaggaga gcagtgctca cccaaaaaca     1080

gaagaagcag cactctgtcc tgcacctggt tcccattaac gccacctcca aggatgactc     1140

cgatgtgaca gaggtgatgt ggcaaccagc tcttaggcgt gggagaggcc tacaggccca     1200

aggatatggt gtccgaatcc aggatgctgg agtttatctg ctgtatagcc aggtcctgtt     1260

tcaagacgtg actttcacca tgggtcaggt ggtgtctcga gaaggccaag gaaggcagga     1320

gactctattc cgatgtataa gaagtatgcc ctcccacccg gaccgggcct acaacagctg     1380

ctatagcgca ggtgtcttcc atttacacca aggggatatt ctgagtgtca taattccccg     1440

ggcaagggcg aaacttaacc tctctccaca tggaaccttc ctggggtttg tgaaactgtg     1500

attgtgttat aaaaagtggc tcccagcttg gaagaccagg gtgggtacat actggagaca     1560

gccaagagct gagtatataa aggagaggga atgtgcagga acagaggcgt cttcctgggt     1620

ttggctcccc gttcctcact tttccctttt cattcccacc ccctagactt tgattttacg     1680

gatatcttgc ttctgttccc catggagctc cgaattcttg cgtgtgtgta gatgaggggc     1740

gggggacggg cgccaggcat tgtccagacc tggtcggggc ccactggaag catccagaac     1800

agcaccacca tctagcggcc gctcgaggga agcacccgcc ggttggccga agtccacgaa     1860

gccgccctct gctagggaaa acccctggtt ctccatgcca cacctctctc caggtgccct     1920

ctgcctcttc accccacaag aagccttatc ctacgtcctt ctctccatct atcggacccc     1980

agtttccatc actatctcca gagatgtagc tattatgcgc ccgtctacag ggggtgcccg     2040

acgatgacgg tgccttcgca gtcaaattac tcttcgggtc ccaaggtttg gctttcacgc     2100

gctccattgc cccggcgtgg caggccattc caagcccttc cgggctggaa ctggtgtcgg     2160

aggagcctcg ggtgtatcgt acgccctggt gttggtgttg cctcactcct ctgagctctt     2220

ctttctgatc aagccctgct taaagttaaa taaaatagaa tgaatgatac cccggcaaaa     2280

aaaaaaaaaa aaa                                                        2293


<210>  2
<211>  250
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Pro Ala Ser Ser Pro Phe Leu Leu Ala Pro Lys Gly Pro Pro Gly 
1               5                   10                  15      


Asn Met Gly Gly Pro Val Arg Glu Pro Ala Leu Ser Val Ala Leu Trp 
            20                  25                  30          


Leu Ser Trp Gly Ala Ala Leu Gly Ala Val Ala Cys Ala Met Ala Leu 
        35                  40                  45              


Leu Thr Gln Gln Thr Glu Leu Gln Ser Leu Arg Arg Glu Val Ser Arg 
    50                  55                  60                  


Leu Gln Gly Thr Gly Gly Pro Ser Gln Asn Gly Glu Gly Tyr Pro Trp 
65                  70                  75                  80  


Gln Ser Leu Pro Glu Gln Ser Ser Asp Ala Leu Glu Ala Trp Glu Asn 
                85                  90                  95      


Gly Glu Arg Ser Arg Lys Arg Arg Ala Val Leu Thr Gln Lys Gln Lys 
            100                 105                 110         


Lys Gln His Ser Val Leu His Leu Val Pro Ile Asn Ala Thr Ser Lys 
        115                 120                 125             


Asp Asp Ser Asp Val Thr Glu Val Met Trp Gln Pro Ala Leu Arg Arg 
    130                 135                 140                 


Gly Arg Gly Leu Gln Ala Gln Gly Tyr Gly Val Arg Ile Gln Asp Ala 
145                 150                 155                 160 


Gly Val Tyr Leu Leu Tyr Ser Gln Val Leu Phe Gln Asp Val Thr Phe 
                165                 170                 175     


Thr Met Gly Gln Val Val Ser Arg Glu Gly Gln Gly Arg Gln Glu Thr 
            180                 185                 190         


Leu Phe Arg Cys Ile Arg Ser Met Pro Ser His Pro Asp Arg Ala Tyr 
        195                 200                 205             


Asn Ser Cys Tyr Ser Ala Gly Val Phe His Leu His Gln Gly Asp Ile 
    210                 215                 220                 


Leu Ser Val Ile Ile Pro Arg Ala Arg Ala Lys Leu Asn Leu Ser Pro 
225                 230                 235                 240 


His Gly Thr Phe Leu Gly Phe Val Lys Leu 
                245                 250 


<210>  3
<211>  2245
<212>  DNA
<213>  Homo sapiens

<400>  3
ccggaaccct gtgtgctggg gaggaatccc gcagtggccg gggggcttga ggccgctgct       60

ttgtctcttc gtccagagcc ttatgtaaga gcttttctcg ggaaacagga agtcctgctt      120

gccaatttca gcacagggag tagtgcaggc cttattccaa cacacccggc ccagccttaa      180

ccccagaact cagccagttt cttgcttccg tgcccctggt tctcctcccc atcgagccca      240

cccctccttt cccaccttca gtcaccccta gtgaactgcc ccagcgatct ctgctgtgct      300

tgaccccgag ggtcttccac cctcgccctg accctggaca ctgcccagct tggcccccca      360

tcctgctcct ggcacaatgc cctctagcca gccaaccttc cctcccccaa ccctggggcc      420

gccccagggt tcctgcgcac tgcctgttcc tcctgggtgt cactggcagc cctgtccttc      480

ctagagggac tggaacctaa ttctcctgag gctgagggag ggtggagggt ctcaaggcaa      540

cgctggcccc acgacggagt gccaggagca ctaacagtac ccttagcttg ctttcctcct      600

ccctcctttt tattttcaag ttccttttta tttctccttg cgtaacaacc ttcttccctt      660

ctgcaccact gcccgtaccc ttacccgccc cgccacctcc ttgctacccc actcttgaaa      720

ccacagctgt tggcagggtc cccagctcat gccagcctca tctcctttct tgctagcccc      780

caaagggcct ccaggcaaca tggggggccc agtcagagag ccggcactct cagttgccct      840

ctggttgagt tggggggcag ctctgggggc cgtggcttgt gccatggctc tgctgaccca      900

acaaacagag ctgcagagcc tcaggagaga ggtgagccgg ctgcagggga caggaggccc      960

ctcccagaat ggggaagggt atccctggca gagtctcccg gagcagagtt ccgatgccct     1020

ggaagcctgg gagaatgggg agagatcccg gaaaaggaga gcagtgctca cccaaaaaca     1080

gaagaatgac tccgatgtga cagaggtgat gtggcaacca gctcttaggc gtgggagagg     1140

cctacaggcc caaggatatg gtgtccgaat ccaggatgct ggagtttatc tgctgtatag     1200

ccaggtcctg tttcaagacg tgactttcac catgggtcag gtggtgtctc gagaaggcca     1260

aggaaggcag gagactctat tccgatgtat aagaagtatg ccctcccacc cggaccgggc     1320

ctacaacagc tgctatagcg caggtgtctt ccatttacac caaggggata ttctgagtgt     1380

cataattccc cgggcaaggg cgaaacttaa cctctctcca catggaacct tcctggggtt     1440

tgtgaaactg tgattgtgtt ataaaaagtg gctcccagct tggaagacca gggtgggtac     1500

atactggaga cagccaagag ctgagtatat aaaggagagg gaatgtgcag gaacagaggc     1560

gtcttcctgg gtttggctcc ccgttcctca cttttccctt ttcattccca ccccctagac     1620

tttgatttta cggatatctt gcttctgttc cccatggagc tccgaattct tgcgtgtgtg     1680

tagatgaggg gcgggggacg ggcgccaggc attgtccaga cctggtcggg gcccactgga     1740

agcatccaga acagcaccac catctagcgg ccgctcgagg gaagcacccg ccggttggcc     1800

gaagtccacg aagccgccct ctgctaggga aaacccctgg ttctccatgc cacacctctc     1860

tccaggtgcc ctctgcctct tcaccccaca agaagcctta tcctacgtcc ttctctccat     1920

ctatcggacc ccagtttcca tcactatctc cagagatgta gctattatgc gcccgtctac     1980

agggggtgcc cgacgatgac ggtgccttcg cagtcaaatt actcttcggg tcccaaggtt     2040

tggctttcac gcgctccatt gccccggcgt ggcaggccat tccaagccct tccgggctgg     2100

aactggtgtc ggaggagcct cgggtgtatc gtacgccctg gtgttggtgt tgcctcactc     2160

ctctgagctc ttctttctga tcaagccctg cttaaagtta aataaaatag aatgaatgat     2220

accccggcaa aaaaaaaaaa aaaaa                                           2245


<210>  4
<211>  234
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Pro Ala Ser Ser Pro Phe Leu Leu Ala Pro Lys Gly Pro Pro Gly 
1               5                   10                  15      


Asn Met Gly Gly Pro Val Arg Glu Pro Ala Leu Ser Val Ala Leu Trp 
            20                  25                  30          


Leu Ser Trp Gly Ala Ala Leu Gly Ala Val Ala Cys Ala Met Ala Leu 
        35                  40                  45              


Leu Thr Gln Gln Thr Glu Leu Gln Ser Leu Arg Arg Glu Val Ser Arg 
    50                  55                  60                  


Leu Gln Gly Thr Gly Gly Pro Ser Gln Asn Gly Glu Gly Tyr Pro Trp 
65                  70                  75                  80  


Gln Ser Leu Pro Glu Gln Ser Ser Asp Ala Leu Glu Ala Trp Glu Asn 
                85                  90                  95      


Gly Glu Arg Ser Arg Lys Arg Arg Ala Val Leu Thr Gln Lys Gln Lys 
            100                 105                 110         


Asn Asp Ser Asp Val Thr Glu Val Met Trp Gln Pro Ala Leu Arg Arg 
        115                 120                 125             


Gly Arg Gly Leu Gln Ala Gln Gly Tyr Gly Val Arg Ile Gln Asp Ala 
    130                 135                 140                 


Gly Val Tyr Leu Leu Tyr Ser Gln Val Leu Phe Gln Asp Val Thr Phe 
145                 150                 155                 160 


Thr Met Gly Gln Val Val Ser Arg Glu Gly Gln Gly Arg Gln Glu Thr 
                165                 170                 175     


Leu Phe Arg Cys Ile Arg Ser Met Pro Ser His Pro Asp Arg Ala Tyr 
            180                 185                 190         


Asn Ser Cys Tyr Ser Ala Gly Val Phe His Leu His Gln Gly Asp Ile 
        195                 200                 205             


Leu Ser Val Ile Ile Pro Arg Ala Arg Ala Lys Leu Asn Leu Ser Pro 
    210                 215                 220                 


His Gly Thr Phe Leu Gly Phe Val Lys Leu 
225                 230                 


<210>  5
<211>  2112
<212>  DNA
<213>  Homo sapiens

<400>  5
ccggaaccct gtgtgctggg gaggaatccc gcagtggccg gggggcttga ggccgctgct       60

ttgtctcttc gtccagagcc ttatgtaaga gcttttctcg ggaaacagga agtcctgctt      120

gccaatttca gcacagggag tagtgcaggc cttattccaa cacacccggc ccagccttaa      180

ccccagaact cagccagttt cttgcttccg tgcccctggt tctcctcccc atcgagccca      240

cccctccttt cccaccttca gtcaccccta gtgaactgcc ccagcgatct ctgctgtgct      300

tgaccccgag ggtcttccac cctcgccctg accctggaca ctgcccagct tggcccccca      360

tcctgctcct ggcacaatgc cctctagcca gccaaccttc cctcccccaa ccctggggcc      420

gccccagggt tcctgcgcac tgcctgttcc tcctgggtgt cactggcagc cctgtccttc      480

ctagagggac tggaacctaa ttctcctgag gctgagggag ggtggagggt ctcaaggcaa      540

cgctggcccc acgacggagt gccaggagca ctaacagtac ccttagcttg ctttcctcct      600

ccctcctttt tattttcaag ttccttttta tttctccttg cgtaacaacc ttcttccctt      660

ctgcaccact gcccgtaccc ttacccgccc cgccacctcc ttgctacccc actcttgaaa      720

ccacagctgt tggcagggtc cccagctcat gccagcctca tctcctttct tgctagcccc      780

caaagggcct ccaggcaaca tggggggccc agtcagagag ccggcactct cagttgccct      840

ctggttgagt tggggggcag ctctgggggc cgtggcttgt gccatggctc tgctgaccca      900

acaaacagag ctgcagagcc tcaggagaga ggtgagccgg ctgcagggga caggaggccc      960

ctcccagaat ggggaagggt atccctggca gagtctcccg gagcagagtt ccgatgccct     1020

ggaagcctgg gagaatgggg agagatcccg gaaaaggaga gcagtgctca cccaaaaaca     1080

gaagaagcag cactctgtcc tgcacctggt tcccattaac gccacctcca aggatgactc     1140

cgatgtgaca gaggtgatgt ggcaaccagc tcttaggcgt gggagaggcc tacaggccca     1200

aggatatggt gtccgaatcc aggatgctgg agtttatctg ctgtatagcc aggtcctgtt     1260

tcaagacgtg actttcacca tgggtcaggt ggtgtctcga gaaggccaag gaaggcagga     1320

gactctattc cgatgtataa gaagtatgcc ctcccacccg gaccgggcct acaacagctg     1380

ctatagcgca ggtgtcttcc atttacacca aggggatatt ctgagtgtca taattccccg     1440

ggcaagggcg aaacttaacc tctctccaca tggaaccttc ctgggacttt gattttacgg     1500

atatcttgct tctgttcccc atggagctcc gaattcttgc gtgtgtgtag atgaggggcg     1560

ggggacgggc gccaggcatt gtccagacct ggtcggggcc cactggaagc atccagaaca     1620

gcaccaccat ctagcggccg ctcgagggaa gcacccgccg gttggccgaa gtccacgaag     1680

ccgccctctg ctagggaaaa cccctggttc tccatgccac acctctctcc aggtgccctc     1740

tgcctcttca ccccacaaga agccttatcc tacgtccttc tctccatcta tcggacccca     1800

gtttccatca ctatctccag agatgtagct attatgcgcc cgtctacagg gggtgcccga     1860

cgatgacggt gccttcgcag tcaaattact cttcgggtcc caaggtttgg ctttcacgcg     1920

ctccattgcc ccggcgtggc aggccattcc aagcccttcc gggctggaac tggtgtcgga     1980

ggagcctcgg gtgtatcgta cgccctggtg ttggtgttgc ctcactcctc tgagctcttc     2040

tttctgatca agccctgctt aaagttaaat aaaatagaat gaatgatacc ccggcaaaaa     2100

aaaaaaaaaa aa                                                         2112


<210>  6
<211>  247
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Pro Ala Ser Ser Pro Phe Leu Leu Ala Pro Lys Gly Pro Pro Gly 
1               5                   10                  15      


Asn Met Gly Gly Pro Val Arg Glu Pro Ala Leu Ser Val Ala Leu Trp 
            20                  25                  30          


Leu Ser Trp Gly Ala Ala Leu Gly Ala Val Ala Cys Ala Met Ala Leu 
        35                  40                  45              


Leu Thr Gln Gln Thr Glu Leu Gln Ser Leu Arg Arg Glu Val Ser Arg 
    50                  55                  60                  


Leu Gln Gly Thr Gly Gly Pro Ser Gln Asn Gly Glu Gly Tyr Pro Trp 
65                  70                  75                  80  


Gln Ser Leu Pro Glu Gln Ser Ser Asp Ala Leu Glu Ala Trp Glu Asn 
                85                  90                  95      


Gly Glu Arg Ser Arg Lys Arg Arg Ala Val Leu Thr Gln Lys Gln Lys 
            100                 105                 110         


Lys Gln His Ser Val Leu His Leu Val Pro Ile Asn Ala Thr Ser Lys 
        115                 120                 125             


Asp Asp Ser Asp Val Thr Glu Val Met Trp Gln Pro Ala Leu Arg Arg 
    130                 135                 140                 


Gly Arg Gly Leu Gln Ala Gln Gly Tyr Gly Val Arg Ile Gln Asp Ala 
145                 150                 155                 160 


Gly Val Tyr Leu Leu Tyr Ser Gln Val Leu Phe Gln Asp Val Thr Phe 
                165                 170                 175     


Thr Met Gly Gln Val Val Ser Arg Glu Gly Gln Gly Arg Gln Glu Thr 
            180                 185                 190         


Leu Phe Arg Cys Ile Arg Ser Met Pro Ser His Pro Asp Arg Ala Tyr 
        195                 200                 205             


Asn Ser Cys Tyr Ser Ala Gly Val Phe His Leu His Gln Gly Asp Ile 
    210                 215                 220                 


Leu Ser Val Ile Ile Pro Arg Ala Arg Ala Lys Leu Asn Leu Ser Pro 
225                 230                 235                 240 


His Gly Thr Phe Leu Gly Leu 
                245         


<210>  7
<211>  2212
<212>  DNA
<213>  Homo sapiens

<400>  7
ccggaaccct gtgtgctggg gaggaatccc gcagtggccg gggggcttga ggccgctgct       60

ttgtctcttc gtccagagcc ttatgtaaga gcttttctcg ggaaacagga agtcctgctt      120

gccaatttca gcacagggag tagtgcaggc cttattccaa cacacccggc ccagccttaa      180

ccccagaact cagccagttt cttgcttccg tgcccctggt tctcctcccc atcgagccca      240

cccctccttt cccaccttca gtcaccccta gtgaactgcc ccagcgatct ctgctgtgct      300

tgaccccgag ggtcttccac cctcgccctg accctggaca ctgcccagct tggcccccca      360

tcctgctcct ggcacaatgc cctctagcca gccaaccttc cctcccccaa ccctggggcc      420

gccccagggt tcctgcgcac tgcctgttcc tcctgggtgt cactggcagc cctgtccttc      480

ctagagggac tggaacctaa ttctcctgag gctgagggag ggtggagggt ctcaaggcaa      540

cgctggcccc acgacggagt gccaggagca ctaacagtac ccttagcttg ctttcctcct      600

ccctcctttt tattttcaag ttccttttta tttctccttg cgtaacaacc ttcttccctt      660

ctgcaccact gcccgtaccc ttacccgccc cgccacctcc ttgctacccc actcttgaaa      720

ccacagctgt tggcagggtc cccagctcat gccagcctca tctcctttct tgctagcccc      780

caaagggcct ccaggcaaca tggggggccc agtcagagag ccggcactct cagttgccct      840

ctggttgagt tggggggcag ctctgggggc cgtggcttgt gccatggctc tgctgaccca      900

acaaacagag ctgcagagcc tcaggagaga ggtgagccgg ctgcagggga caggaggccc      960

ctcccagaat ggggaagggt atccctggca gagtctcccg gagcagcagc actctgtcct     1020

gcacctggtt cccattaacg ccacctccaa ggatgactcc gatgtgacag aggtgatgtg     1080

gcaaccagct cttaggcgtg ggagaggcct acaggcccaa ggatatggtg tccgaatcca     1140

ggatgctgga gtttatctgc tgtatagcca ggtcctgttt caagacgtga ctttcaccat     1200

gggtcaggtg gtgtctcgag aaggccaagg aaggcaggag actctattcc gatgtataag     1260

aagtatgccc tcccacccgg accgggccta caacagctgc tatagcgcag gtgtcttcca     1320

tttacaccaa ggggatattc tgagtgtcat aattccccgg gcaagggcga aacttaacct     1380

ctctccacat ggaaccttcc tggggtttgt gaaactgtga ttgtgttata aaaagtggct     1440

cccagcttgg aagaccaggg tgggtacata ctggagacag ccaagagctg agtatataaa     1500

ggagagggaa tgtgcaggaa cagaggcgtc ttcctgggtt tggctccccg ttcctcactt     1560

ttcccttttc attcccaccc cctagacttt gattttacgg atatcttgct tctgttcccc     1620

atggagctcc gaattcttgc gtgtgtgtag atgaggggcg ggggacgggc gccaggcatt     1680

gtccagacct ggtcggggcc cactggaagc atccagaaca gcaccaccat ctagcggccg     1740

ctcgagggaa gcacccgccg gttggccgaa gtccacgaag ccgccctctg ctagggaaaa     1800

cccctggttc tccatgccac acctctctcc aggtgccctc tgcctcttca ccccacaaga     1860

agccttatcc tacgtccttc tctccatcta tcggacccca gtttccatca ctatctccag     1920

agatgtagct attatgcgcc cgtctacagg gggtgcccga cgatgacggt gccttcgcag     1980

tcaaattact cttcgggtcc caaggtttgg ctttcacgcg ctccattgcc ccggcgtggc     2040

aggccattcc aagcccttcc gggctggaac tggtgtcgga ggagcctcgg gtgtatcgta     2100

cgccctggtg ttggtgttgc ctcactcctc tgagctcttc tttctgatca agccctgctt     2160

aaagttaaat aaaatagaat gaatgatacc ccggcaaaaa aaaaaaaaaa aa             2212


<210>  8
<211>  223
<212>  PRT
<213>  Homo sapiens

<400>  8

Met Pro Ala Ser Ser Pro Phe Leu Leu Ala Pro Lys Gly Pro Pro Gly 
1               5                   10                  15      


Asn Met Gly Gly Pro Val Arg Glu Pro Ala Leu Ser Val Ala Leu Trp 
            20                  25                  30          


Leu Ser Trp Gly Ala Ala Leu Gly Ala Val Ala Cys Ala Met Ala Leu 
        35                  40                  45              


Leu Thr Gln Gln Thr Glu Leu Gln Ser Leu Arg Arg Glu Val Ser Arg 
    50                  55                  60                  


Leu Gln Gly Thr Gly Gly Pro Ser Gln Asn Gly Glu Gly Tyr Pro Trp 
65                  70                  75                  80  


Gln Ser Leu Pro Glu Gln Gln His Ser Val Leu His Leu Val Pro Ile 
                85                  90                  95      


Asn Ala Thr Ser Lys Asp Asp Ser Asp Val Thr Glu Val Met Trp Gln 
            100                 105                 110         


Pro Ala Leu Arg Arg Gly Arg Gly Leu Gln Ala Gln Gly Tyr Gly Val 
        115                 120                 125             


Arg Ile Gln Asp Ala Gly Val Tyr Leu Leu Tyr Ser Gln Val Leu Phe 
    130                 135                 140                 


Gln Asp Val Thr Phe Thr Met Gly Gln Val Val Ser Arg Glu Gly Gln 
145                 150                 155                 160 


Gly Arg Gln Glu Thr Leu Phe Arg Cys Ile Arg Ser Met Pro Ser His 
                165                 170                 175     


Pro Asp Arg Ala Tyr Asn Ser Cys Tyr Ser Ala Gly Val Phe His Leu 
            180                 185                 190         


His Gln Gly Asp Ile Leu Ser Val Ile Ile Pro Arg Ala Arg Ala Lys 
        195                 200                 205             


Leu Asn Leu Ser Pro His Gly Thr Phe Leu Gly Phe Val Lys Leu 
    210                 215                 220             


<210>  9
<211>  2209
<212>  DNA
<213>  Homo sapiens

<400>  9
ccggaaccct gtgtgctggg gaggaatccc gcagtggccg gggggcttga ggccgctgct       60

ttgtctcttc gtccagagcc ttatgtaaga gcttttctcg ggaaacagga agtcctgctt      120

gccaatttca gcacagggag tagtgcaggc cttattccaa cacacccggc ccagccttaa      180

ccccagaact cagccagttt cttgcttccg tgcccctggt tctcctcccc atcgagccca      240

cccctccttt cccaccttca gtcaccccta gtgaactgcc ccagcgatct ctgctgtgct      300

tgaccccgag ggtcttccac cctcgccctg accctggaca ctgcccagct tggcccccca      360

tcctgctcct ggcacaatgc cctctagcca gccaaccttc cctcccccaa ccctggggcc      420

gccccagggt tcctgcgcac tgcctgttcc tcctgggtgt cactggcagc cctgtccttc      480

ctagagggac tggaacctaa ttctcctgag gctgagggag ggtggagggt ctcaaggcaa      540

cgctggcccc acgacggagt gccaggagca ctaacagtac ccttagcttg ctttcctcct      600

ccctcctttt tattttcaag ttccttttta tttctccttg cgtaacaacc ttcttccctt      660

ctgcaccact gcccgtaccc ttacccgccc cgccacctcc ttgctacccc actcttgaaa      720

ccacagctgt tggcagggtc cccagctcat gccagcctca tctcctttct tgctagcccc      780

caaagggcct ccaggcaaca tggggggccc agtcagagag ccggcactct cagttgccct      840

ctggttgagt tggggggcag ctctgggggc cgtggcttgt gccatggctc tgctgaccca      900

acaaacagag ctgcagagcc tcaggagaga ggtgagccgg ctgcagggga caggaggccc      960

ctcccagaat ggggaagggt atccctggca gagtctcccg gagcagcact ctgtcctgca     1020

cctggttccc attaacgcca cctccaagga tgactccgat gtgacagagg tgatgtggca     1080

accagctctt aggcgtggga gaggcctaca ggcccaagga tatggtgtcc gaatccagga     1140

tgctggagtt tatctgctgt atagccaggt cctgtttcaa gacgtgactt tcaccatggg     1200

tcaggtggtg tctcgagaag gccaaggaag gcaggagact ctattccgat gtataagaag     1260

tatgccctcc cacccggacc gggcctacaa cagctgctat agcgcaggtg tcttccattt     1320

acaccaaggg gatattctga gtgtcataat tccccgggca agggcgaaac ttaacctctc     1380

tccacatgga accttcctgg ggtttgtgaa actgtgattg tgttataaaa agtggctccc     1440

agcttggaag accagggtgg gtacatactg gagacagcca agagctgagt atataaagga     1500

gagggaatgt gcaggaacag aggcgtcttc ctgggtttgg ctccccgttc ctcacttttc     1560

ccttttcatt cccaccccct agactttgat tttacggata tcttgcttct gttccccatg     1620

gagctccgaa ttcttgcgtg tgtgtagatg aggggcgggg gacgggcgcc aggcattgtc     1680

cagacctggt cggggcccac tggaagcatc cagaacagca ccaccatcta gcggccgctc     1740

gagggaagca cccgccggtt ggccgaagtc cacgaagccg ccctctgcta gggaaaaccc     1800

ctggttctcc atgccacacc tctctccagg tgccctctgc ctcttcaccc cacaagaagc     1860

cttatcctac gtccttctct ccatctatcg gaccccagtt tccatcacta tctccagaga     1920

tgtagctatt atgcgcccgt ctacaggggg tgcccgacga tgacggtgcc ttcgcagtca     1980

aattactctt cgggtcccaa ggtttggctt tcacgcgctc cattgccccg gcgtggcagg     2040

ccattccaag cccttccggg ctggaactgg tgtcggagga gcctcgggtg tatcgtacgc     2100

cctggtgttg gtgttgcctc actcctctga gctcttcttt ctgatcaagc cctgcttaaa     2160

gttaaataaa atagaatgaa tgataccccg gcaaaaaaaa aaaaaaaaa                 2209


<210>  10
<211>  222
<212>  PRT
<213>  Homo sapiens

<400>  10

Met Pro Ala Ser Ser Pro Phe Leu Leu Ala Pro Lys Gly Pro Pro Gly 
1               5                   10                  15      


Asn Met Gly Gly Pro Val Arg Glu Pro Ala Leu Ser Val Ala Leu Trp 
            20                  25                  30          


Leu Ser Trp Gly Ala Ala Leu Gly Ala Val Ala Cys Ala Met Ala Leu 
        35                  40                  45              


Leu Thr Gln Gln Thr Glu Leu Gln Ser Leu Arg Arg Glu Val Ser Arg 
    50                  55                  60                  


Leu Gln Gly Thr Gly Gly Pro Ser Gln Asn Gly Glu Gly Tyr Pro Trp 
65                  70                  75                  80  


Gln Ser Leu Pro Glu Gln His Ser Val Leu His Leu Val Pro Ile Asn 
                85                  90                  95      


Ala Thr Ser Lys Asp Asp Ser Asp Val Thr Glu Val Met Trp Gln Pro 
            100                 105                 110         


Ala Leu Arg Arg Gly Arg Gly Leu Gln Ala Gln Gly Tyr Gly Val Arg 
        115                 120                 125             


Ile Gln Asp Ala Gly Val Tyr Leu Leu Tyr Ser Gln Val Leu Phe Gln 
    130                 135                 140                 


Asp Val Thr Phe Thr Met Gly Gln Val Val Ser Arg Glu Gly Gln Gly 
145                 150                 155                 160 


Arg Gln Glu Thr Leu Phe Arg Cys Ile Arg Ser Met Pro Ser His Pro 
                165                 170                 175     


Asp Arg Ala Tyr Asn Ser Cys Tyr Ser Ala Gly Val Phe His Leu His 
            180                 185                 190         


Gln Gly Asp Ile Leu Ser Val Ile Ile Pro Arg Ala Arg Ala Lys Leu 
        195                 200                 205             


Asn Leu Ser Pro His Gly Thr Phe Leu Gly Phe Val Lys Leu 
    210                 215                 220         


<210>  11
<211>  1517
<212>  DNA
<213>  Homo sapiens

<400>  11
ccggaaccct gtgtgctggg gaggaatccc gcagtggccg gggggcttga ggccgctgct       60

ttgtctcttc gtccagagcc ttatccccca aagggcctcc aggcaacatg gggggcccag      120

tcagagagcc ggcactctca gttgccctct ggttgagttg gggggcagct ctgggggccg      180

tggcttgtgc catggctctg ctgacccaac aaacagagct gcagagcctc aggagagagg      240

tgagccggct gcaggggaca ggaggcccct cccagaatgg ggaagggtat ccctggcaga      300

gtctcccgga gcagcactct gtcctgcacc tggttcccat taacgccacc tccaaggatg      360

actccgatgt gacagaggtg atgtggcaac cagctcttag gcgtgggaga ggcctacagg      420

cccaaggata tggtgtccga atccaggatg ctggagttta tctgctgtat agccaggtcc      480

tgtttcaaga cgtgactttc accatgggtc aggtggtgtc tcgagaaggc caaggaaggc      540

aggagactct attccgatgt ataagaagta tgccctccca cccggaccgg gcctacaaca      600

gctgctatag cgcaggtgtc ttccatttac accaagggga tattctgagt gtcataattc      660

cccgggcaag ggcgaaactt aacctctctc cacatggaac cttcctgggg tttgtgaaac      720

tgtgattgtg ttataaaaag tggctcccag cttggaagac cagggtgggt acatactgga      780

gacagccaag agctgagtat ataaaggaga gggaatgtgc aggaacagag gcgtcttcct      840

gggtttggct ccccgttcct cacttttccc ttttcattcc caccccctag actttgattt      900

tacggatatc ttgcttctgt tccccatgga gctccgaatt cttgcgtgtg tgtagatgag      960

gggcggggga cgggcgccag gcattgtcca gacctggtcg gggcccactg gaagcatcca     1020

gaacagcacc accatctagc ggccgctcga gggaagcacc cgccggttgg ccgaagtcca     1080

cgaagccgcc ctctgctagg gaaaacccct ggttctccat gccacacctc tctccaggtg     1140

ccctctgcct cttcacccca caagaagcct tatcctacgt ccttctctcc atctatcgga     1200

ccccagtttc catcactatc tccagagatg tagctattat gcgcccgtct acagggggtg     1260

cccgacgatg acggtgcctt cgcagtcaaa ttactcttcg ggtcccaagg tttggctttc     1320

acgcgctcca ttgccccggc gtggcaggcc attccaagcc cttccgggct ggaactggtg     1380

tcggaggagc ctcgggtgta tcgtacgccc tggtgttggt gttgcctcac tcctctgagc     1440

tcttctttct gatcaagccc tgcttaaagt taaataaaat agaatgaatg ataccccggc     1500

aaaaaaaaaa aaaaaaa                                                    1517


<210>  12
<211>  205
<212>  PRT
<213>  Homo sapiens

<400>  12

Met Gly Gly Pro Val Arg Glu Pro Ala Leu Ser Val Ala Leu Trp Leu 
1               5                   10                  15      


Ser Trp Gly Ala Ala Leu Gly Ala Val Ala Cys Ala Met Ala Leu Leu 
            20                  25                  30          


Thr Gln Gln Thr Glu Leu Gln Ser Leu Arg Arg Glu Val Ser Arg Leu 
        35                  40                  45              


Gln Gly Thr Gly Gly Pro Ser Gln Asn Gly Glu Gly Tyr Pro Trp Gln 
    50                  55                  60                  


Ser Leu Pro Glu Gln His Ser Val Leu His Leu Val Pro Ile Asn Ala 
65                  70                  75                  80  


Thr Ser Lys Asp Asp Ser Asp Val Thr Glu Val Met Trp Gln Pro Ala 
                85                  90                  95      


Leu Arg Arg Gly Arg Gly Leu Gln Ala Gln Gly Tyr Gly Val Arg Ile 
            100                 105                 110         


Gln Asp Ala Gly Val Tyr Leu Leu Tyr Ser Gln Val Leu Phe Gln Asp 
        115                 120                 125             


Val Thr Phe Thr Met Gly Gln Val Val Ser Arg Glu Gly Gln Gly Arg 
    130                 135                 140                 


Gln Glu Thr Leu Phe Arg Cys Ile Arg Ser Met Pro Ser His Pro Asp 
145                 150                 155                 160 


Arg Ala Tyr Asn Ser Cys Tyr Ser Ala Gly Val Phe His Leu His Gln 
                165                 170                 175     


Gly Asp Ile Leu Ser Val Ile Ile Pro Arg Ala Arg Ala Lys Leu Asn 
            180                 185                 190         


Leu Ser Pro His Gly Thr Phe Leu Gly Phe Val Lys Leu 
        195                 200                 205 


<210>  13
<211>  1679
<212>  DNA
<213>  Mus musculus

<400>  13
gaaggctggc cgctccttct gggtgtcacg gctgccctgt ccttcctaga taatggcacc       60

aaattctcct gaggctaggg gggaaggagt gtcagagtgt cactagctcg accctgggga      120

caagggggac taatagtacc ctagcttgat ttcttcctat tctcaagttc ctttttattt      180

ctcccttgcg taacccgctc ttcccttctg tgcctttgcc tgtattccca ccctccctgc      240

tacctcttgg ccacctcact tctgagacca cagctgttgg cagggtccct agctcatgcc      300

agcctcatct ccaggccaca tggggggctc agtcagagag ccagcccttt cggttgctct      360

ttggttgagt tggggggcag ttctgggggc tgtgacttgt gctgtcgcac tactgatcca      420

acagacagag ctgcaaagcc taaggcggga ggtgagccgg ctgcagcgga gtggagggcc      480

ttcccagaag cagggagagc gcccatggca gagcctctgg gagcagagtc ctgatgtcct      540

ggaagcctgg aaggatgggg cgaaatctcg gagaaggaga gcagtactca cccagaagca      600

caagaagaag cactcagtcc tgcatcttgt tccagttaac attacctcca aggcagactc      660

tgacgtgaca gaggtgatgt ggcaaccagt acttaggcgt gggagaggcc tggaggccca      720

gggagacatt gtacgagtct gggacactgg aatttatctg ctctatagtc aggtcctgtt      780

tcatgatgtg actttcacaa tgggtcaggt ggtatctcgg gaaggacaag ggagaagaga      840

aactctattc cgatgtatca gaagtatgcc ttctgatcct gaccgtgcct acaatagctg      900

ctacagtgca ggtgtctttc atttacatca aggggatatt atcactgtca aaattccacg      960

ggcaaacgca aaacttagcc tttctccgca tggaacattc ctggggtttg tgaaactatg     1020

attgttataa agggggtggg gatttcccat tccaaaaact ggctagacaa aggacaagga     1080

acggtcaaga acagctctcc atggctttgc cttgactgtt gttcctccct ttgcctttcc     1140

cgctcccact atctgggctt tgactccatg gatattaaaa aagtagaata ttttgtgttt     1200

atctcccaca cagccccaaa ttcttttgtt gtgtgtgcga agggggtttt gcgcactgtg     1260

ccaagccttg tccactggaa tgcatccaga acagcagcac catctagcgg caggttgagg     1320

aaagactatg gtctctgcta gggaaaacct tatccaactc ttcaagtacc ctctgcttca     1380

attaacaaga agcccggctt tcagtatttc acctattgcg tccaaattct tgttactatc     1440

tagaaaaaga tatatgttag gtgcctcgat atgcatgcca ttcatcctcc ccattctcct     1500

atacacttcc gagctgggca ctgagcttta cgccttaaat cacagtactc gggaggcaga     1560

tctcgatgag ttcgaggcca acttggtcta aatagtgagt tccaggccac ccaggggtta     1620

caatggtgag accctgtctc aaacaaacta acaaacaaat aaacgaaagg ctctccacg      1679


<210>  14
<211>  241
<212>  PRT
<213>  Mus musculus

<400>  14

Met Pro Ala Ser Ser Pro Gly His Met Gly Gly Ser Val Arg Glu Pro 
1               5                   10                  15      


Ala Leu Ser Val Ala Leu Trp Leu Ser Trp Gly Ala Val Leu Gly Ala 
            20                  25                  30          


Val Thr Cys Ala Val Ala Leu Leu Ile Gln Gln Thr Glu Leu Gln Ser 
        35                  40                  45              


Leu Arg Arg Glu Val Ser Arg Leu Gln Arg Ser Gly Gly Pro Ser Gln 
    50                  55                  60                  


Lys Gln Gly Glu Arg Pro Trp Gln Ser Leu Trp Glu Gln Ser Pro Asp 
65                  70                  75                  80  


Val Leu Glu Ala Trp Lys Asp Gly Ala Lys Ser Arg Arg Arg Arg Ala 
                85                  90                  95      


Val Leu Thr Gln Lys His Lys Lys Lys His Ser Val Leu His Leu Val 
            100                 105                 110         


Pro Val Asn Ile Thr Ser Lys Ala Asp Ser Asp Val Thr Glu Val Met 
        115                 120                 125             


Trp Gln Pro Val Leu Arg Arg Gly Arg Gly Leu Glu Ala Gln Gly Asp 
    130                 135                 140                 


Ile Val Arg Val Trp Asp Thr Gly Ile Tyr Leu Leu Tyr Ser Gln Val 
145                 150                 155                 160 


Leu Phe His Asp Val Thr Phe Thr Met Gly Gln Val Val Ser Arg Glu 
                165                 170                 175     


Gly Gln Gly Arg Arg Glu Thr Leu Phe Arg Cys Ile Arg Ser Met Pro 
            180                 185                 190         


Ser Asp Pro Asp Arg Ala Tyr Asn Ser Cys Tyr Ser Ala Gly Val Phe 
        195                 200                 205             


His Leu His Gln Gly Asp Ile Ile Thr Val Lys Ile Pro Arg Ala Asn 
    210                 215                 220                 


Ala Lys Leu Ser Leu Ser Pro His Gly Thr Phe Leu Gly Phe Val Lys 
225                 230                 235                 240 


Leu 
    


<210>  15
<211>  1676
<212>  DNA
<213>  Mus musculus

<400>  15
gaaggctggc cgctccttct gggtgtcacg gctgccctgt ccttcctaga taatggcacc       60

aaattctcct gaggctaggg gggaaggagt gtcagagtgt cactagctcg accctgggga      120

caagggggac taatagtacc ctagcttgat ttcttcctat tctcaagttc ctttttattt      180

ctcccttgcg taacccgctc ttcccttctg tgcctttgcc tgtattccca ccctccctgc      240

tacctcttgg ccacctcact tctgagacca cagctgttgg cagggtccct agctcatgcc      300

agcctcatct ccaggccaca tggggggctc agtcagagag ccagcccttt cggttgctct      360

ttggttgagt tggggggcag ttctgggggc tgtgacttgt gctgtcgcac tactgatcca      420

acagacagag ctgcaaagcc taaggcggga ggtgagccgg ctgcagcgga gtggagggcc      480

ttcccagaag cagggagagc gcccatggca gagcctctgg gagcagagtc ctgatgtcct      540

ggaagcctgg aaggatgggg cgaaatctcg gagaaggaga gcagtactca cccagaagca      600

caagaagaag cactcagtcc tgcatcttgt tccagttaac attacctcca aggactctga      660

cgtgacagag gtgatgtggc aaccagtact taggcgtggg agaggcctgg aggcccaggg      720

agacattgta cgagtctggg acactggaat ttatctgctc tatagtcagg tcctgtttca      780

tgatgtgact ttcacaatgg gtcaggtggt atctcgggaa ggacaaggga gaagagaaac      840

tctattccga tgtatcagaa gtatgccttc tgatcctgac cgtgcctaca atagctgcta      900

cagtgcaggt gtctttcatt tacatcaagg ggatattatc actgtcaaaa ttccacgggc      960

aaacgcaaaa cttagccttt ctccgcatgg aacattcctg gggtttgtga aactatgatt     1020

gttataaagg gggtggggat ttcccattcc aaaaactggc tagacaaagg acaaggaacg     1080

gtcaagaaca gctctccatg gctttgcctt gactgttgtt cctccctttg cctttcccgc     1140

tcccactatc tgggctttga ctccatggat attaaaaaag tagaatattt tgtgtttatc     1200

tcccacacag ccccaaattc ttttgttgtg tgtgcgaagg gggttttgcg cactgtgcca     1260

agccttgtcc actggaatgc atccagaaca gcagcaccat ctagcggcag gttgaggaaa     1320

gactatggtc tctgctaggg aaaaccttat ccaactcttc aagtaccctc tgcttcaatt     1380

aacaagaagc ccggctttca gtatttcacc tattgcgtcc aaattcttgt tactatctag     1440

aaaaagatat atgttaggtg cctcgatatg catgccattc atcctcccca ttctcctata     1500

cacttccgag ctgggcactg agctttacgc cttaaatcac agtactcggg aggcagatct     1560

cgatgagttc gaggccaact tggtctaaat agtgagttcc aggccaccca ggggttacaa     1620

tggtgagacc ctgtctcaaa caaactaaca aacaaataaa cgaaaggctc tccacg         1676


<210>  16
<211>  240
<212>  PRT
<213>  Mus musculus

<400>  16

Met Pro Ala Ser Ser Pro Gly His Met Gly Gly Ser Val Arg Glu Pro 
1               5                   10                  15      


Ala Leu Ser Val Ala Leu Trp Leu Ser Trp Gly Ala Val Leu Gly Ala 
            20                  25                  30          


Val Thr Cys Ala Val Ala Leu Leu Ile Gln Gln Thr Glu Leu Gln Ser 
        35                  40                  45              


Leu Arg Arg Glu Val Ser Arg Leu Gln Arg Ser Gly Gly Pro Ser Gln 
    50                  55                  60                  


Lys Gln Gly Glu Arg Pro Trp Gln Ser Leu Trp Glu Gln Ser Pro Asp 
65                  70                  75                  80  


Val Leu Glu Ala Trp Lys Asp Gly Ala Lys Ser Arg Arg Arg Arg Ala 
                85                  90                  95      


Val Leu Thr Gln Lys His Lys Lys Lys His Ser Val Leu His Leu Val 
            100                 105                 110         


Pro Val Asn Ile Thr Ser Lys Asp Ser Asp Val Thr Glu Val Met Trp 
        115                 120                 125             


Gln Pro Val Leu Arg Arg Gly Arg Gly Leu Glu Ala Gln Gly Asp Ile 
    130                 135                 140                 


Val Arg Val Trp Asp Thr Gly Ile Tyr Leu Leu Tyr Ser Gln Val Leu 
145                 150                 155                 160 


Phe His Asp Val Thr Phe Thr Met Gly Gln Val Val Ser Arg Glu Gly 
                165                 170                 175     


Gln Gly Arg Arg Glu Thr Leu Phe Arg Cys Ile Arg Ser Met Pro Ser 
            180                 185                 190         


Asp Pro Asp Arg Ala Tyr Asn Ser Cys Tyr Ser Ala Gly Val Phe His 
        195                 200                 205             


Leu His Gln Gly Asp Ile Ile Thr Val Lys Ile Pro Arg Ala Asn Ala 
    210                 215                 220                 


Lys Leu Ser Leu Ser Pro His Gly Thr Phe Leu Gly Phe Val Lys Leu 
225                 230                 235                 240 


<210>  17
<211>  1377
<212>  DNA
<213>  Homo sapiens

<400>  17
agcatcctga gtaatgagtg gcctgggccg gagcaggcga ggtggccgga gccgtgtgga       60

ccaggaggag cgctttccac agggcctgtg gacgggggtg gctatgagat cctgccccga      120

agagcagtac tgggatcctc tgctgggtac ctgcatgtcc tgcaaaacca tttgcaacca      180

tcagagccag cgcacctgtg cagccttctg caggtcactc agctgccgca aggagcaagg      240

caagttctat gaccatctcc tgagggactg catcagctgt gcctccatct gtggacagca      300

ccctaagcaa tgtgcatact tctgtgagaa caagctcagg agcccagtga accttccacc      360

agagctcagg agacagcgga gtggagaagt tgaaaacaat tcagacaact cgggaaggta      420

ccaaggattg gagcacagag gctcagaagc aagtccagct ctcccggggc tgaagctgag      480

tgcagatcag gtggccctgg tctacagcac gctggggctc tgcctgtgtg ccgtcctctg      540

ctgcttcctg gtggcggtgg cctgcttcct caagaagagg ggggatccct gctcctgcca      600

gccccgctca aggccccgtc aaagtccggc caagtcttcc caggatcacg cgatggaagc      660

cggcagccct gtgagcacat cccccgagcc agtggagacc tgcagcttct gcttccctga      720

gtgcagggcg cccacgcagg agagcgcagt cacgcctggg acccccgacc ccacttgtgc      780

tggaaggtgg gggtgccaca ccaggaccac agtcctgcag ccttgcccac acatcccaga      840

cagtggcctt ggcattgtgt gtgtgcctgc ccaggagggg ggcccaggtg cataaatggg      900

ggtcagggag ggaaaggagg agggagagag atggagagga ggggagagag aaagagaggt      960

ggggagaggg gagagagata tgaggagaga gagacagagg aggcagagag ggagagaaac     1020

agaggagaca gagagggaga gagagacaga gggagagaga gacagagggg aagagaggca     1080

gagagggaaa gaggcagaga aggaaagaga caggcagaga aggagagagg cagagaggga     1140

gagaggcaga gagggagaga ggcagagaga cagagaggga gagagggaca gagagagata     1200

gagcaggagg tcggggcact ctgagtccca gttcccagtg cagctgtagg tcgtcatcac     1260

ctaaccacac gtgcaataaa gtcctcgtgc ctgctgctca cagcccccga gagcccctcc     1320

tcctggagaa taaaaccttt ggcagctgcc cttcctcaaa aaaaaaaaaa aaaaaaa        1377


<210>  18
<211>  293
<212>  PRT
<213>  Homo sapiens

<400>  18

Met Ser Gly Leu Gly Arg Ser Arg Arg Gly Gly Arg Ser Arg Val Asp 
1               5                   10                  15      


Gln Glu Glu Arg Phe Pro Gln Gly Leu Trp Thr Gly Val Ala Met Arg 
            20                  25                  30          


Ser Cys Pro Glu Glu Gln Tyr Trp Asp Pro Leu Leu Gly Thr Cys Met 
        35                  40                  45              


Ser Cys Lys Thr Ile Cys Asn His Gln Ser Gln Arg Thr Cys Ala Ala 
    50                  55                  60                  


Phe Cys Arg Ser Leu Ser Cys Arg Lys Glu Gln Gly Lys Phe Tyr Asp 
65                  70                  75                  80  


His Leu Leu Arg Asp Cys Ile Ser Cys Ala Ser Ile Cys Gly Gln His 
                85                  90                  95      


Pro Lys Gln Cys Ala Tyr Phe Cys Glu Asn Lys Leu Arg Ser Pro Val 
            100                 105                 110         


Asn Leu Pro Pro Glu Leu Arg Arg Gln Arg Ser Gly Glu Val Glu Asn 
        115                 120                 125             


Asn Ser Asp Asn Ser Gly Arg Tyr Gln Gly Leu Glu His Arg Gly Ser 
    130                 135                 140                 


Glu Ala Ser Pro Ala Leu Pro Gly Leu Lys Leu Ser Ala Asp Gln Val 
145                 150                 155                 160 


Ala Leu Val Tyr Ser Thr Leu Gly Leu Cys Leu Cys Ala Val Leu Cys 
                165                 170                 175     


Cys Phe Leu Val Ala Val Ala Cys Phe Leu Lys Lys Arg Gly Asp Pro 
            180                 185                 190         


Cys Ser Cys Gln Pro Arg Ser Arg Pro Arg Gln Ser Pro Ala Lys Ser 
        195                 200                 205             


Ser Gln Asp His Ala Met Glu Ala Gly Ser Pro Val Ser Thr Ser Pro 
    210                 215                 220                 


Glu Pro Val Glu Thr Cys Ser Phe Cys Phe Pro Glu Cys Arg Ala Pro 
225                 230                 235                 240 


Thr Gln Glu Ser Ala Val Thr Pro Gly Thr Pro Asp Pro Thr Cys Ala 
                245                 250                 255     


Gly Arg Trp Gly Cys His Thr Arg Thr Thr Val Leu Gln Pro Cys Pro 
            260                 265                 270         


His Ile Pro Asp Ser Gly Leu Gly Ile Val Cys Val Pro Ala Gln Glu 
        275                 280                 285             


Gly Gly Pro Gly Ala 
    290             


<210>  19
<211>  750
<212>  DNA
<213>  Mus musculus

<400>  19
atggctatgg cattctgccc caaagatcag tactgggact cctcaaggaa atcctgtgtc       60

tcctgtgcac tgacctgcag ccagaggagc cagcgcacct gtacagactt ctgcaaattc      120

atcaattgcc gaaaagagca aggcaggtac tacgaccatc tcctgggggc ctgcgtcagc      180

tgtgactcca cctgcacaca gcaccctcag cagtgtgccc acttctgtga gaaaaggccc      240

agaagccagg cgaacctcca gcccgagctc gggagaccac aggccgggga ggtggaagtc      300

aggtcagaca actcaggaag gcaccaggga tctgagcatg gtccaggatt gaggctaagt      360

agcgaccagc tgactctcta ctgcacactg ggggtctgcc tctgcgccat cttctgctgt      420

ttcttggtgg ccttggcctc cttcctcagg cgtagaggag agccactacc cagccagcct      480

gccgggccac gtgggtcaca agcaaactct ccccacgccc accgccccgt gacagaggct      540

tgcgacgagg tgaccgcgtc accccagcct gtggaaacgt gtagcttctg cttcccggag      600

cgcagttctc ccactcagga gagcgcgccg cgttcgctcg ggatacacgg cttcgcgggc      660

actgccgccc cgcagccctg tatgcgtgca acagtaggcg gcctgggtgt cctgcgcgca      720

tccactgggg acgctcgtcc ggcaacttga                                       750


<210>  20
<211>  249
<212>  PRT
<213>  Mus musculus

<400>  20

Met Ala Met Ala Phe Cys Pro Lys Asp Gln Tyr Trp Asp Ser Ser Arg 
1               5                   10                  15      


Lys Ser Cys Val Ser Cys Ala Leu Thr Cys Ser Gln Arg Ser Gln Arg 
            20                  25                  30          


Thr Cys Thr Asp Phe Cys Lys Phe Ile Asn Cys Arg Lys Glu Gln Gly 
        35                  40                  45              


Arg Tyr Tyr Asp His Leu Leu Gly Ala Cys Val Ser Cys Asp Ser Thr 
    50                  55                  60                  


Cys Thr Gln His Pro Gln Gln Cys Ala His Phe Cys Glu Lys Arg Pro 
65                  70                  75                  80  


Arg Ser Gln Ala Asn Leu Gln Pro Glu Leu Gly Arg Pro Gln Ala Gly 
                85                  90                  95      


Glu Val Glu Val Arg Ser Asp Asn Ser Gly Arg His Gln Gly Ser Glu 
            100                 105                 110         


His Gly Pro Gly Leu Arg Leu Ser Ser Asp Gln Leu Thr Leu Tyr Cys 
        115                 120                 125             


Thr Leu Gly Val Cys Leu Cys Ala Ile Phe Cys Cys Phe Leu Val Ala 
    130                 135                 140                 


Leu Ala Ser Phe Leu Arg Arg Arg Gly Glu Pro Leu Pro Ser Gln Pro 
145                 150                 155                 160 


Ala Gly Pro Arg Gly Ser Gln Ala Asn Ser Pro His Ala His Arg Pro 
                165                 170                 175     


Val Thr Glu Ala Cys Asp Glu Val Thr Ala Ser Pro Gln Pro Val Glu 
            180                 185                 190         


Thr Cys Ser Phe Cys Phe Pro Glu Arg Ser Ser Pro Thr Gln Glu Ser 
        195                 200                 205             


Ala Pro Arg Ser Leu Gly Ile His Gly Phe Ala Gly Thr Ala Ala Pro 
    210                 215                 220                 


Gln Pro Cys Met Arg Ala Thr Val Gly Gly Leu Gly Val Leu Arg Ala 
225                 230                 235                 240 


Ser Thr Gly Asp Ala Arg Pro Ala Thr 
                245                 


<210>  21
<211>  994
<212>  DNA
<213>  Homo sapiens

<400>  21
aagactcaaa cttagaaact tgaattagat gtggtattca aatccttagc tgccgcgaag       60

acacagacag cccccgtaag aacccacgaa gcaggcgaag ttcattgttc tcaacattct      120

agctgctctt gctgcatttg ctctggaatt cttgtagaga tattacttgt ccttccaggc      180

tgttctttct gtagctccct tgttttcttt ttgtgatcat gttgcagatg gctgggcagt      240

gctcccaaaa tgaatatttt gacagtttgt tgcatgcttg cataccttgt caacttcgat      300

gttcttctaa tactcctcct ctaacatgtc agcgttattg taatgcaagt gtgaccaatt      360

cagtgaaagg aacgaatgcg attctctgga cctgtttggg actgagctta ataatttctt      420

tggcagtttt cgtgctaatg tttttgctaa ggaagataaa ctctgaacca ttaaaggacg      480

agtttaaaaa cacaggatca ggtctcctgg gcatggctaa cattgacctg gaaaagagca      540

ggactggtga tgaaattatt cttccgagag gcctcgagta cacggtggaa gaatgcacct      600

gtgaagactg catcaagagc aaaccgaagg tcgactctga ccattgcttt ccactcccag      660

ctatggagga aggcgcaacc attcttgtca ccacgaaaac gaatgactat tgcaagagcc      720

tgccagctgc tttgagtgct acggagatag agaaatcaat ttctgctagg taattaacca      780

tttcgactcg agcagtgcca ctttaaaaat cttttgtcag aatagatgat gtgtcagatc      840

tctttaggat gactgtattt ttcagttgcc gatacagctt tttgtcctct aactgtggaa      900

actctttatg ttagatatat ttctctaggt tactgttggg agcttaatgg tagaaacttc      960

cttggtttca tgattaaact cttttttttc ctga                                  994


<210>  22
<211>  184
<212>  PRT
<213>  Homo sapiens

<400>  22

Met Leu Gln Met Ala Gly Gln Cys Ser Gln Asn Glu Tyr Phe Asp Ser 
1               5                   10                  15      


Leu Leu His Ala Cys Ile Pro Cys Gln Leu Arg Cys Ser Ser Asn Thr 
            20                  25                  30          


Pro Pro Leu Thr Cys Gln Arg Tyr Cys Asn Ala Ser Val Thr Asn Ser 
        35                  40                  45              


Val Lys Gly Thr Asn Ala Ile Leu Trp Thr Cys Leu Gly Leu Ser Leu 
    50                  55                  60                  


Ile Ile Ser Leu Ala Val Phe Val Leu Met Phe Leu Leu Arg Lys Ile 
65                  70                  75                  80  


Asn Ser Glu Pro Leu Lys Asp Glu Phe Lys Asn Thr Gly Ser Gly Leu 
                85                  90                  95      


Leu Gly Met Ala Asn Ile Asp Leu Glu Lys Ser Arg Thr Gly Asp Glu 
            100                 105                 110         


Ile Ile Leu Pro Arg Gly Leu Glu Tyr Thr Val Glu Glu Cys Thr Cys 
        115                 120                 125             


Glu Asp Cys Ile Lys Ser Lys Pro Lys Val Asp Ser Asp His Cys Phe 
    130                 135                 140                 


Pro Leu Pro Ala Met Glu Glu Gly Ala Thr Ile Leu Val Thr Thr Lys 
145                 150                 155                 160 


Thr Asn Asp Tyr Cys Lys Ser Leu Pro Ala Ala Leu Ser Ala Thr Glu 
                165                 170                 175     


Ile Glu Lys Ser Ile Ser Ala Arg 
            180                 


<210>  23
<211>  812
<212>  DNA
<213>  Mus musculus

<400>  23
cacaatacct gtggccctct taagagcagc agggtctttc tttccgcctg acttcctgtc       60

cacagggaac tcccacagag aatctgctgt tcttcctcga ttttctgtcc actcttcccg      120

tttctttcag tgatccagtc cctcatggcg caacagtgtt tccacagtga atattttgac      180

agtctgctgc atgcttgcaa accgtgtcac ttgcgatgtt ccaaccctcc tgcaacctgt      240

cagccttact gtgatccaag cgtgaccagt tcagtgaaag ggacgtacac ggtgctctgg      300

atcttcttgg ggctgacctt ggtcctctct ttggcacttt tcacaatctc attcttgctg      360

aggaagatga accccgaggc cctgaaggac gagcctcaaa gcccaggtca gcttgacgga      420

tcggctcagc tggacaaggc cgacaccgag ctgactagga tcagggctgg tgacgacagg      480

atctttcccc gaagcctgga gtatacagtg gaagagtgca cctgtgagga ctgtgtcaag      540

agcaaaccca agggggattc tgaccatttc ttcccgcttc cagccatgga ggagggggca      600

accattcttg tcaccacaaa aacgggtgac tacggcaagt caagtgtgcc aactgctttg      660

caaagtgtca tggggatgga gaagccaact cacactagat aatgagcttc ctaactggtg      720

tgaagctgct ttgagaacct tctgtcagga gagctggtgt tttagatgtc gttaggatga      780

ccgtttacca accaagaata cagttttttg tc                                    812


<210>  24
<211>  185
<212>  PRT
<213>  Mus musculus

<400>  24

Met Ala Gln Gln Cys Phe His Ser Glu Tyr Phe Asp Ser Leu Leu His 
1               5                   10                  15      


Ala Cys Lys Pro Cys His Leu Arg Cys Ser Asn Pro Pro Ala Thr Cys 
            20                  25                  30          


Gln Pro Tyr Cys Asp Pro Ser Val Thr Ser Ser Val Lys Gly Thr Tyr 
        35                  40                  45              


Thr Val Leu Trp Ile Phe Leu Gly Leu Thr Leu Val Leu Ser Leu Ala 
    50                  55                  60                  


Leu Phe Thr Ile Ser Phe Leu Leu Arg Lys Met Asn Pro Glu Ala Leu 
65                  70                  75                  80  


Lys Asp Glu Pro Gln Ser Pro Gly Gln Leu Asp Gly Ser Ala Gln Leu 
                85                  90                  95      


Asp Lys Ala Asp Thr Glu Leu Thr Arg Ile Arg Ala Gly Asp Asp Arg 
            100                 105                 110         


Ile Phe Pro Arg Ser Leu Glu Tyr Thr Val Glu Glu Cys Thr Cys Glu 
        115                 120                 125             


Asp Cys Val Lys Ser Lys Pro Lys Gly Asp Ser Asp His Phe Phe Pro 
    130                 135                 140                 


Leu Pro Ala Met Glu Glu Gly Ala Thr Ile Leu Val Thr Thr Lys Thr 
145                 150                 155                 160 


Gly Asp Tyr Gly Lys Ser Ser Val Pro Thr Ala Leu Gln Ser Val Met 
                165                 170                 175     


Gly Met Glu Lys Pro Thr His Thr Arg 
            180                 185