                         SEQUENCE LISTING

<110>  Cell Design Labs, Inc.
 
<120>  METHODS AND COMPOSITIONS FOR REDUCING THE IMMUNOGENICITY OF 
       CHIMERIC NOTCH RECEPTORS

<130>  43159-0066WO1

<150>  US 62/603,993
<151>  2017-06-19

<150>  US 62/556,765
<151>  2017-09-11

<160>  35    

<170>  PatentIn version 3.5

<210>  1
<211>  22
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Ser 
            20          


<210>  2
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Myc tag

<400>  2

Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu 
1               5                   10  


<210>  3
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GS linker

<400>  3

Gly Ser Ala Ala Ala Gly Gly Ser Gly Gly Ser Gly Gly Ser 
1               5                   10                  


<210>  4
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GS linker

<400>  4

Gly Gly Gly Ser Gly Gly Gly Ser 
1               5               


<210>  5
<211>  638
<212>  PRT
<213>  Homo sapiens

<400>  5

Met Val Ser Lys Leu Ser Gln Leu Gln Thr Glu Leu Leu Ala Ala Leu 
1               5                   10                  15      


Leu Glu Ser Gly Leu Ser Lys Glu Ala Leu Ile Gln Ala Leu Gly Glu 
            20                  25                  30          


Pro Gly Pro Tyr Leu Leu Ala Gly Glu Gly Pro Leu Asp Lys Gly Glu 
        35                  40                  45              


Ser Cys Gly Gly Gly Arg Gly Glu Leu Ala Glu Leu Pro Asn Gly Leu 
    50                  55                  60                  


Gly Glu Thr Arg Gly Ser Glu Asp Glu Thr Asp Asp Asp Gly Glu Asp 
65                  70                  75                  80  


Phe Thr Pro Pro Ile Leu Lys Glu Leu Glu Asn Leu Ser Pro Glu Glu 
                85                  90                  95      


Ala Ala His Gln Lys Ala Val Val Glu Thr Leu Leu Gln Glu Asp Pro 
            100                 105                 110         


Trp Arg Val Ala Lys Met Val Lys Ser Tyr Leu Gln Gln His Asn Ile 
        115                 120                 125             


Pro Gln Arg Glu Val Val Asp Thr Thr Gly Leu Asn Gln Ser His Leu 
    130                 135                 140                 


Ser Gln His Leu Asn Lys Gly Thr Pro Met Lys Thr Gln Lys Arg Ala 
145                 150                 155                 160 


Ala Leu Tyr Thr Trp Tyr Val Arg Lys Gln Arg Glu Val Ala Gln Gln 
                165                 170                 175     


Phe Thr His Ala Gly Gln Gly Gly Leu Ile Glu Glu Pro Thr Gly Asp 
            180                 185                 190         


Glu Leu Pro Thr Lys Lys Gly Arg Arg Asn Arg Phe Lys Trp Gly Pro 
        195                 200                 205             


Ala Ser Gln Gln Ile Leu Phe Gln Ala Tyr Glu Arg Gln Lys Asn Pro 
    210                 215                 220                 


Ser Lys Glu Glu Arg Glu Thr Leu Val Glu Glu Cys Asn Arg Ala Glu 
225                 230                 235                 240 


Cys Ile Gln Arg Gly Val Ser Pro Ser Gln Ala Gln Gly Leu Gly Ser 
                245                 250                 255     


Asn Leu Val Thr Glu Val Arg Val Tyr Asn Trp Phe Ala Asn Arg Arg 
            260                 265                 270         


Lys Glu Glu Ala Phe Arg His Lys Leu Ala Met Asp Thr Tyr Ser Gly 
        275                 280                 285             


Pro Pro Pro Gly Pro Gly Pro Gly Pro Ala Leu Pro Ala His Ser Ser 
    290                 295                 300                 


Pro Gly Leu Pro Pro Pro Ala Leu Ser Pro Ser Lys Val His Gly Val 
305                 310                 315                 320 


Arg Tyr Gly Gln Pro Ala Thr Ser Glu Thr Ala Glu Val Pro Ser Ser 
                325                 330                 335     


Ser Gly Gly Pro Leu Val Thr Val Ser Thr Pro Leu His Gln Val Ser 
            340                 345                 350         


Pro Thr Gly Leu Glu Pro Ser His Ser Leu Leu Ser Thr Glu Ala Lys 
        355                 360                 365             


Leu Val Ser Ala Ala Gly Gly Pro Leu Pro Pro Val Ser Thr Leu Thr 
    370                 375                 380                 


Ala Leu His Ser Leu Glu Gln Thr Ser Pro Gly Leu Asn Gln Gln Pro 
385                 390                 395                 400 


Gln Asn Leu Ile Met Ala Ser Leu Pro Gly Val Met Thr Ile Gly Pro 
                405                 410                 415     


Gly Glu Pro Ala Ser Leu Gly Pro Thr Phe Thr Asn Thr Gly Ala Ser 
            420                 425                 430         


Thr Leu Val Ile Gly Leu Ala Ser Thr Gln Ala Gln Ser Val Pro Val 
        435                 440                 445             


Ile Asn Ser Met Gly Ser Ser Leu Thr Thr Leu Gln Pro Val Gln Phe 
    450                 455                 460                 


Ser Gln Pro Leu His Pro Ser Tyr Gln Gln Pro Leu Met Pro Pro Val 
465                 470                 475                 480 


Gln Ser His Val Thr Gln Ser Pro Phe Met Ala Thr Met Ala Gln Leu 
                485                 490                 495     


Gln Ser Pro His Ala Leu Tyr Ser His Lys Pro Glu Val Ala Gln Tyr 
            500                 505                 510         


Thr His Thr Gly Leu Leu Pro Gln Thr Met Leu Ile Thr Asp Thr Thr 
        515                 520                 525             


Asn Leu Ser Ala Leu Ala Ser Leu Thr Pro Thr Lys Gln Glu Ala Ala 
    530                 535                 540                 


Leu Leu Pro Gln Val Phe Thr Ser Asp Thr Glu Ala Ser Ser Glu Ser 
545                 550                 555                 560 


Gly Leu His Thr Pro Ala Ser Gln Ala Thr Thr Leu His Val Pro Ser 
                565                 570                 575     


Gln Asp Pro Ala Gly Ile Gln His Leu Gln Pro Ala His Arg Leu Ser 
            580                 585                 590         


Ala Ser Pro Thr Val Ser Ser Ser Ser Leu Val Leu Tyr Gln Ser Ser 
        595                 600                 605             


Asp Ser Ser Asn Gly Gln Ser His Leu Leu Pro Ser Asn His Ser Val 
    610                 615                 620                 


Ile Glu Thr Phe Ile Ser Thr Gln Met Ala Ser Ser Ser Gln 
625                 630                 635             


<210>  6
<211>  631
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Val Ser Lys Leu Ser Gln Leu Gln Thr Glu Leu Leu Ala Ala Leu 
1               5                   10                  15      


Leu Glu Ser Gly Leu Ser Lys Glu Ala Leu Ile Gln Ala Leu Gly Glu 
            20                  25                  30          


Pro Gly Pro Tyr Leu Leu Ala Gly Glu Gly Pro Leu Asp Lys Gly Glu 
        35                  40                  45              


Ser Cys Gly Gly Gly Arg Gly Glu Leu Ala Glu Leu Pro Asn Gly Leu 
    50                  55                  60                  


Gly Glu Thr Arg Gly Ser Glu Asp Glu Thr Asp Asp Asp Gly Glu Asp 
65                  70                  75                  80  


Phe Thr Pro Pro Ile Leu Lys Glu Leu Glu Asn Leu Ser Pro Glu Glu 
                85                  90                  95      


Ala Ala His Gln Lys Ala Val Val Glu Thr Leu Leu Gln Glu Asp Pro 
            100                 105                 110         


Trp Arg Val Ala Lys Met Val Lys Ser Tyr Leu Gln Gln His Asn Ile 
        115                 120                 125             


Pro Gln Arg Glu Val Val Asp Thr Thr Gly Leu Asn Gln Ser His Leu 
    130                 135                 140                 


Ser Gln His Leu Asn Lys Gly Thr Pro Met Lys Thr Gln Lys Arg Ala 
145                 150                 155                 160 


Ala Leu Tyr Thr Trp Tyr Val Arg Lys Gln Arg Glu Val Ala Gln Gln 
                165                 170                 175     


Phe Thr His Ala Gly Gln Gly Gly Leu Ile Glu Glu Pro Thr Gly Asp 
            180                 185                 190         


Glu Leu Pro Thr Lys Lys Gly Arg Arg Asn Arg Phe Lys Trp Gly Pro 
        195                 200                 205             


Ala Ser Gln Gln Ile Leu Phe Gln Ala Tyr Glu Arg Gln Lys Asn Pro 
    210                 215                 220                 


Ser Lys Glu Glu Arg Glu Thr Leu Val Glu Glu Cys Asn Arg Ala Glu 
225                 230                 235                 240 


Cys Ile Gln Arg Gly Val Ser Pro Ser Gln Ala Gln Gly Leu Gly Ser 
                245                 250                 255     


Asn Leu Val Thr Glu Val Arg Val Tyr Asn Trp Phe Ala Asn Arg Arg 
            260                 265                 270         


Lys Glu Glu Ala Phe Arg His Lys Leu Ala Met Asp Thr Tyr Ser Gly 
        275                 280                 285             


Pro Pro Pro Gly Pro Gly Pro Gly Pro Ala Leu Pro Ala His Ser Ser 
    290                 295                 300                 


Pro Gly Leu Pro Pro Pro Ala Leu Ser Pro Ser Lys Val His Gly Val 
305                 310                 315                 320 


Arg Tyr Gly Gln Pro Ala Thr Ser Glu Thr Ala Glu Val Pro Ser Ser 
                325                 330                 335     


Ser Gly Gly Pro Leu Val Thr Val Ser Thr Pro Leu His Gln Val Ser 
            340                 345                 350         


Pro Thr Gly Leu Glu Pro Ser His Ser Leu Leu Ser Thr Glu Ala Lys 
        355                 360                 365             


Leu Val Ser Ala Ala Gly Gly Pro Leu Pro Pro Val Ser Thr Leu Thr 
    370                 375                 380                 


Ala Leu His Ser Leu Glu Gln Thr Ser Pro Gly Leu Asn Gln Gln Pro 
385                 390                 395                 400 


Gln Asn Leu Ile Met Ala Ser Leu Pro Gly Val Met Thr Ile Gly Pro 
                405                 410                 415     


Gly Glu Pro Ala Ser Leu Gly Pro Thr Phe Thr Asn Thr Gly Ala Ser 
            420                 425                 430         


Thr Leu Val Ile Gly Leu Ala Ser Thr Gln Ala Gln Ser Val Pro Val 
        435                 440                 445             


Ile Asn Ser Met Gly Ser Ser Leu Thr Thr Leu Gln Pro Val Gln Phe 
    450                 455                 460                 


Ser Gln Pro Leu His Pro Ser Tyr Gln Gln Pro Leu Met Pro Pro Val 
465                 470                 475                 480 


Gln Ser His Val Thr Gln Ser Pro Phe Met Ala Thr Met Ala Gln Leu 
                485                 490                 495     


Gln Ser Pro His Ala Leu Tyr Ser His Lys Pro Glu Val Ala Gln Tyr 
            500                 505                 510         


Thr His Thr Gly Leu Leu Pro Gln Thr Met Leu Ile Thr Asp Thr Thr 
        515                 520                 525             


Asn Leu Ser Ala Leu Ala Ser Leu Thr Pro Thr Lys Gln Val Phe Thr 
    530                 535                 540                 


Ser Asp Thr Glu Ala Ser Ser Glu Ser Gly Leu His Thr Pro Ala Ser 
545                 550                 555                 560 


Gln Ala Thr Thr Leu His Val Pro Ser Gln Asp Pro Ala Gly Ile Gln 
                565                 570                 575     


His Leu Gln Pro Ala His Arg Leu Ser Ala Ser Pro Thr Val Ser Ser 
            580                 585                 590         


Ser Ser Leu Val Leu Tyr Gln Ser Ser Asp Ser Ser Asn Gly Gln Ser 
        595                 600                 605             


His Leu Leu Pro Ser Asn His Ser Val Ile Glu Thr Phe Ile Ser Thr 
    610                 615                 620                 


Gln Met Ala Ser Ser Ser Gln 
625                 630     


<210>  7
<211>  662
<212>  PRT
<213>  Homo sapiens

<400>  7

Met Val Ser Lys Leu Ser Gln Leu Gln Thr Glu Leu Leu Ala Ala Leu 
1               5                   10                  15      


Leu Glu Ser Gly Leu Ser Lys Glu Ala Leu Ile Gln Ala Leu Gly Glu 
            20                  25                  30          


Pro Gly Pro Tyr Leu Leu Ala Gly Glu Gly Pro Leu Asp Lys Gly Glu 
        35                  40                  45              


Ser Cys Gly Gly Gly Arg Gly Glu Leu Ala Glu Leu Pro Asn Gly Leu 
    50                  55                  60                  


Gly Glu Thr Arg Gly Ser Glu Asp Glu Thr Asp Asp Asp Gly Glu Asp 
65                  70                  75                  80  


Phe Thr Pro Pro Ile Leu Lys Glu Leu Glu Asn Leu Ser Pro Glu Glu 
                85                  90                  95      


Ala Ala His Gln Lys Ala Val Val Glu Thr Leu Leu Gln Glu Asp Pro 
            100                 105                 110         


Trp Arg Val Ala Lys Met Val Lys Ser Tyr Leu Gln Gln His Asn Ile 
        115                 120                 125             


Pro Gln Arg Glu Val Val Asp Thr Thr Gly Leu Asn Gln Ser His Leu 
    130                 135                 140                 


Ser Gln His Leu Asn Lys Gly Thr Pro Met Lys Thr Gln Lys Arg Ala 
145                 150                 155                 160 


Ala Leu Tyr Thr Trp Tyr Val Arg Lys Gln Arg Glu Val Ala Gln Gln 
                165                 170                 175     


Phe Thr His Ala Gly Gln Gly Gly Leu Ile Glu Glu Pro Thr Gly Asp 
            180                 185                 190         


Glu Leu Pro Thr Lys Lys Gly Arg Arg Asn Arg Phe Lys Trp Gly Pro 
        195                 200                 205             


Ala Ser Gln Gln Ile Leu Phe Gln Ala Tyr Glu Arg Gln Lys Asn Pro 
    210                 215                 220                 


Ser Lys Glu Glu Arg Glu Thr Leu Val Glu Glu Cys Asn Arg Ala Glu 
225                 230                 235                 240 


Cys Ile Gln Arg Gly Val Ser Pro Ser Gln Ala Gln Gly Leu Gly Ser 
                245                 250                 255     


Asn Leu Val Thr Glu Val Arg Val Tyr Asn Trp Phe Ala Asn Arg Arg 
            260                 265                 270         


Lys Glu Glu Ala Phe Arg His Lys Leu Ala Met Asp Thr Tyr Ser Gly 
        275                 280                 285             


Pro Pro Pro Gly Pro Gly Pro Gly Pro Ala Leu Pro Ala His Ser Ser 
    290                 295                 300                 


Pro Gly Leu Pro Pro Pro Ala Leu Ser Pro Ser Lys Val His Gly Val 
305                 310                 315                 320 


Arg Tyr Gly Gln Pro Ala Thr Ser Glu Thr Ala Glu Val Pro Ser Ser 
                325                 330                 335     


Ser Gly Gly Pro Leu Val Thr Val Ser Thr Pro Leu His Gln Val Ser 
            340                 345                 350         


Pro Thr Gly Leu Glu Pro Ser His Ser Leu Leu Ser Thr Glu Ala Lys 
        355                 360                 365             


Leu Val Ser Ala Ala Gly Gly Pro Leu Pro Pro Val Ser Thr Leu Thr 
    370                 375                 380                 


Ala Leu His Ser Leu Glu Gln Thr Ser Pro Gly Leu Asn Gln Gln Pro 
385                 390                 395                 400 


Gln Asn Leu Ile Met Ala Ser Leu Pro Gly Val Met Thr Ile Gly Pro 
                405                 410                 415     


Gly Glu Pro Ala Ser Leu Gly Pro Thr Phe Thr Asn Thr Gly Ala Ser 
            420                 425                 430         


Thr Leu Val Ile Gly Leu Ala Ser Thr Gln Ala Gln Ser Val Pro Val 
        435                 440                 445             


Ile Asn Ser Met Gly Ser Ser Leu Thr Thr Leu Gln Pro Val Gln Phe 
    450                 455                 460                 


Ser Gln Pro Leu His Pro Ser Tyr Gln Gln Pro Leu Met Pro Pro Val 
465                 470                 475                 480 


Gln Ser His Val Thr Gln Ser Pro Phe Met Ala Thr Met Ala Gln Leu 
                485                 490                 495     


Gln Ser Pro His Ala Leu Tyr Ser His Lys Pro Glu Val Ala Gln Tyr 
            500                 505                 510         


Thr His Thr Gly Leu Leu Pro Gln Thr Met Leu Ile Thr Asp Thr Thr 
        515                 520                 525             


Asn Leu Ser Ala Leu Ala Ser Leu Thr Pro Thr Lys Gln Val Arg Ser 
    530                 535                 540                 


Arg Pro Ala Gly Pro Pro Leu Ala Cys Asp Arg Ala Pro His Pro His 
545                 550                 555                 560 


Ile Pro Arg Ala Gln Glu Ala Ala Leu Leu Pro Gln Val Phe Thr Ser 
                565                 570                 575     


Asp Thr Glu Ala Ser Ser Glu Ser Gly Leu His Thr Pro Ala Ser Gln 
            580                 585                 590         


Ala Thr Thr Leu His Val Pro Ser Gln Asp Pro Ala Ser Ile Gln His 
        595                 600                 605             


Leu Gln Pro Ala His Arg Leu Ser Ala Ser Pro Thr Val Ser Ser Ser 
    610                 615                 620                 


Ser Leu Val Leu Tyr Gln Ser Ser Asp Ser Ser Asn Gly Gln Ser His 
625                 630                 635                 640 


Leu Leu Pro Ser Asn His Ser Val Ile Glu Thr Phe Ile Ser Thr Gln 
                645                 650                 655     


Met Ala Ser Ser Ser Gln 
            660         


<210>  8
<211>  3438
<212>  DNA
<213>  Homo sapiens

<400>  8
ggggccctga ttcacgggcc gctggggcca gggttggggg ttgggggtgc ccacagggct       60

tggctagtgg ggttttgggg gggcagtggg tgcaaggagt ttggtttgtg tctgccggcc      120

ggcaggcaaa cgcaacccac gcggtggggg aggcggctag cgtggtggac ccgggccgcg      180

tggccctgtg gcagccgagc catggtttct aaactgagcc agctgcagac ggagctcctg      240

gcggccctgc tcgagtcagg gctgagcaaa gaggcactga tccaggcact gggtgagccg      300

gggccctacc tcctggctgg agaaggcccc ctggacaagg gggagtcctg cggcggcggt      360

cgaggggagc tggctgagct gcccaatggg ctgggggaga ctcggggctc cgaggacgag      420

acggacgacg atggggaaga cttcacgcca cccatcctca aagagctgga gaacctcagc      480

cctgaggagg cggcccacca gaaagccgtg gtggagaccc ttctgcagga ggacccgtgg      540

cgtgtggcga agatggtcaa gtcctacctg cagcagcaca acatcccaca gcgggaggtg      600

gtcgatacca ctggcctcaa ccagtcccac ctgtcccaac acctcaacaa gggcactccc      660

atgaagacgc agaagcgggc cgccctgtac acctggtacg tccgcaagca gcgagaggtg      720

gcgcagcagt tcacccatgc agggcaggga gggctgattg aagagcccac aggtgatgag      780

ctaccaacca agaaggggcg gaggaaccgt ttcaagtggg gcccagcatc ccagcagatc      840

ctgttccagg cctatgagag gcagaagaac cctagcaagg aggagcgaga gacgctagtg      900

gaggagtgca atagggcgga atgcatccag agaggggtgt ccccatcaca ggcacagggg      960

ctgggctcca acctcgtcac ggaggtgcgt gtctacaact ggtttgccaa ccggcgcaaa     1020

gaagaagcct tccggcacaa gctggccatg gacacgtaca gcgggccccc cccagggcca     1080

ggcccgggac ctgcgctgcc cgctcacagc tcccctggcc tgcctccacc tgccctctcc     1140

cccagtaagg tccacggtgt gcgctatgga cagcctgcga ccagtgagac tgcagaagta     1200

ccctcaagca gcggcggtcc cttagtgaca gtgtctacac ccctccacca agtgtccccc     1260

acgggcctgg agcccagcca cagcctgctg agtacagaag ccaagctggt ctcagcagct     1320

gggggccccc tcccccctgt cagcaccctg acagcactgc acagcttgga gcagacatcc     1380

ccaggcctca accagcagcc ccagaacctc atcatggcct cacttcctgg ggtcatgacc     1440

atcgggcctg gtgagcctgc ctccctgggt cctacgttca ccaacacagg tgcctccacc     1500

ctggtcatcg gcctggcctc cacgcaggca cagagtgtgc cggtcatcaa cagcatgggc     1560

agcagcctga ccaccctgca gcccgtccag ttctcccagc cgctgcaccc ctcctaccag     1620

cagccgctca tgccacctgt gcagagccat gtgacccaga gccccttcat ggccaccatg     1680

gctcagctgc agagccccca cgccctctac agccacaagc ccgaggtggc ccagtacacc     1740

cacacgggcc tgctcccgca gactatgctc atcaccgaca ccaccaacct gagcgccctg     1800

gccagcctca cgcccaccaa gcaggaggct gctctgctcc cccaggtctt cacctcagac     1860

actgaggcct ccagtgagtc cgggcttcac acgccggcat ctcaggccac caccctccac     1920

gtccccagcc aggaccctgc cggcatccag cacctgcagc cggcccaccg gctcagcgcc     1980

agccccacag tgtcctccag cagcctggtg ctgtaccaga gctcagactc cagcaatggc     2040

cagagccacc tgctgccatc caaccacagc gtcatcgaga ccttcatctc cacccagatg     2100

gcctcttcct cccagtaacc acggcacctg ggccctgggg cctgtactgc ctgcttgggg     2160

ggtgatgagg gcagcagcca gccctgcctg gaggacctga gcctgccgag caaccgtggc     2220

ccttcctgga cagctgtgcc tcgctcccca ctctgctctg atgcatcaga aagggagggc     2280

tctgaggcgc cccaacccgt ggaggctgct cggggtgcac aggagggggt cgtggagagc     2340

taggagcaaa gcctgttcat ggcagatgta ggagggactg tcgctgcttc gtgggataca     2400

gtcttcttac ttggaactga agggggcggc ctatgacttg ggcaccccca gcctgggcct     2460

atggagagcc ctgggaccgc tacaccactc tggcagccac acttctcagg acacaggcct     2520

gtgtagctgt gacctgctga gctctgagag gccctggatc agcgtggcct tgttctgtca     2580

ccaatgtacc caccgggcca ctccttcctg ccccaactcc ttccagctag tgacccacat     2640

gccatttgta ctgaccccat cacctactca cacaggcatt tcctgggtgg ctactctgtg     2700

ccagagcctg gggctctaac gcctgagccc agggaggccg aagctaacag ggaaggcagg     2760

cagggctctc ctggcttccc atccccagcg attccctctc ccaggcccca tgacctccag     2820

ctttcctgta tttgttccca agagcatcat gcctctgagg ccagcctggc ctcctgcctc     2880

tactgggaag gctacttcgg ggctgggaag tcgtccttac tcctgtggga gcctcgcaac     2940

ccgtgccaag tccaggtcct ggtggggcag ctcctctgtc tcgagcgccc tgcagaccct     3000

gcccttgttt ggggcaggag tagctgagct cacaaggcag caaggcccga gcagctgagc     3060

agggccgggg aactggccaa gctgaggtgc ccaggagaag aaagaggtga ccccagggca     3120

caggagctac ctgtgtggac aggactaaca ctcagaagcc tgggggcctg gctggctgag     3180

ggcagttcgc agccaccctg aggagtctga ggtcctgagc actgccagga gggacaaagg     3240

agcctgtgaa cccaggacaa gcatggtccc acatccctgg gcctgctgct gagaacctgg     3300

ccttcagtgt accgcgtcta ccctgggatt caggaaaagg cctggggtga cccggcaccc     3360

cctgcagctt gtagccagcc ggggcgagtg gcacgtttat ttaactttta gtaaagtcaa     3420

ggagaaatgc ggtggaaa                                                   3438


<210>  9
<211>  3417
<212>  DNA
<213>  Homo sapiens

<400>  9
ggggccctga ttcacgggcc gctggggcca gggttggggg ttgggggtgc ccacagggct       60

tggctagtgg ggttttgggg gggcagtggg tgcaaggagt ttggtttgtg tctgccggcc      120

ggcaggcaaa cgcaacccac gcggtggggg aggcggctag cgtggtggac ccgggccgcg      180

tggccctgtg gcagccgagc catggtttct aaactgagcc agctgcagac ggagctcctg      240

gcggccctgc tcgagtcagg gctgagcaaa gaggcactga tccaggcact gggtgagccg      300

gggccctacc tcctggctgg agaaggcccc ctggacaagg gggagtcctg cggcggcggt      360

cgaggggagc tggctgagct gcccaatggg ctgggggaga ctcggggctc cgaggacgag      420

acggacgacg atggggaaga cttcacgcca cccatcctca aagagctgga gaacctcagc      480

cctgaggagg cggcccacca gaaagccgtg gtggagaccc ttctgcagga ggacccgtgg      540

cgtgtggcga agatggtcaa gtcctacctg cagcagcaca acatcccaca gcgggaggtg      600

gtcgatacca ctggcctcaa ccagtcccac ctgtcccaac acctcaacaa gggcactccc      660

atgaagacgc agaagcgggc cgccctgtac acctggtacg tccgcaagca gcgagaggtg      720

gcgcagcagt tcacccatgc agggcaggga gggctgattg aagagcccac aggtgatgag      780

ctaccaacca agaaggggcg gaggaaccgt ttcaagtggg gcccagcatc ccagcagatc      840

ctgttccagg cctatgagag gcagaagaac cctagcaagg aggagcgaga gacgctagtg      900

gaggagtgca atagggcgga atgcatccag agaggggtgt ccccatcaca ggcacagggg      960

ctgggctcca acctcgtcac ggaggtgcgt gtctacaact ggtttgccaa ccggcgcaaa     1020

gaagaagcct tccggcacaa gctggccatg gacacgtaca gcgggccccc cccagggcca     1080

ggcccgggac ctgcgctgcc cgctcacagc tcccctggcc tgcctccacc tgccctctcc     1140

cccagtaagg tccacggtgt gcgctatgga cagcctgcga ccagtgagac tgcagaagta     1200

ccctcaagca gcggcggtcc cttagtgaca gtgtctacac ccctccacca agtgtccccc     1260

acgggcctgg agcccagcca cagcctgctg agtacagaag ccaagctggt ctcagcagct     1320

gggggccccc tcccccctgt cagcaccctg acagcactgc acagcttgga gcagacatcc     1380

ccaggcctca accagcagcc ccagaacctc atcatggcct cacttcctgg ggtcatgacc     1440

atcgggcctg gtgagcctgc ctccctgggt cctacgttca ccaacacagg tgcctccacc     1500

ctggtcatcg gcctggcctc cacgcaggca cagagtgtgc cggtcatcaa cagcatgggc     1560

agcagcctga ccaccctgca gcccgtccag ttctcccagc cgctgcaccc ctcctaccag     1620

cagccgctca tgccacctgt gcagagccat gtgacccaga gccccttcat ggccaccatg     1680

gctcagctgc agagccccca cgccctctac agccacaagc ccgaggtggc ccagtacacc     1740

cacacgggcc tgctcccgca gactatgctc atcaccgaca ccaccaacct gagcgccctg     1800

gccagcctca cgcccaccaa gcaggtcttc acctcagaca ctgaggcctc cagtgagtcc     1860

gggcttcaca cgccggcatc tcaggccacc accctccacg tccccagcca ggaccctgcc     1920

ggcatccagc acctgcagcc ggcccaccgg ctcagcgcca gccccacagt gtcctccagc     1980

agcctggtgc tgtaccagag ctcagactcc agcaatggcc agagccacct gctgccatcc     2040

aaccacagcg tcatcgagac cttcatctcc acccagatgg cctcttcctc ccagtaacca     2100

cggcacctgg gccctggggc ctgtactgcc tgcttggggg gtgatgaggg cagcagccag     2160

ccctgcctgg aggacctgag cctgccgagc aaccgtggcc cttcctggac agctgtgcct     2220

cgctccccac tctgctctga tgcatcagaa agggagggct ctgaggcgcc ccaacccgtg     2280

gaggctgctc ggggtgcaca ggagggggtc gtggagagct aggagcaaag cctgttcatg     2340

gcagatgtag gagggactgt cgctgcttcg tgggatacag tcttcttact tggaactgaa     2400

gggggcggcc tatgacttgg gcacccccag cctgggccta tggagagccc tgggaccgct     2460

acaccactct ggcagccaca cttctcagga cacaggcctg tgtagctgtg acctgctgag     2520

ctctgagagg ccctggatca gcgtggcctt gttctgtcac caatgtaccc accgggccac     2580

tccttcctgc cccaactcct tccagctagt gacccacatg ccatttgtac tgaccccatc     2640

acctactcac acaggcattt cctgggtggc tactctgtgc cagagcctgg ggctctaacg     2700

cctgagccca gggaggccga agctaacagg gaaggcaggc agggctctcc tggcttccca     2760

tccccagcga ttccctctcc caggccccat gacctccagc tttcctgtat ttgttcccaa     2820

gagcatcatg cctctgaggc cagcctggcc tcctgcctct actgggaagg ctacttcggg     2880

gctgggaagt cgtccttact cctgtgggag cctcgcaacc cgtgccaagt ccaggtcctg     2940

gtggggcagc tcctctgtct cgagcgccct gcagaccctg cccttgtttg gggcaggagt     3000

agctgagctc acaaggcagc aaggcccgag cagctgagca gggccgggga actggccaag     3060

ctgaggtgcc caggagaaga aagaggtgac cccagggcac aggagctacc tgtgtggaca     3120

ggactaacac tcagaagcct gggggcctgg ctggctgagg gcagttcgca gccaccctga     3180

ggagtctgag gtcctgagca ctgccaggag ggacaaagga gcctgtgaac ccaggacaag     3240

catggtccca catccctggg cctgctgctg agaacctggc cttcagtgta ccgcgtctac     3300

cctgggattc aggaaaaggc ctggggtgac ccggcacccc ctgcagcttg tagccagccg     3360

gggcgagtgg cacgtttatt taacttttag taaagtcaag gagaaatgcg gtggaaa        3417


<210>  10
<211>  3563
<212>  DNA
<213>  Homo sapiens

<400>  10
ataaatatga accttggaga atttccccag ctccaatgta aacagaacag gcaggggccc       60

tgattcacgg gccgctgggg ccagggttgg gggttggggg tgcccacagg gcttggctag      120

tggggttttg ggggggcagt gggtgcaagg agtttggttt gtgtctgccg gccggcaggc      180

aaacgcaacc cacgcggtgg gggaggcggc tagcgtggtg gacccgggcc gcgtggccct      240

gtggcagccg agccatggtt tctaaactga gccagctgca gacggagctc ctggcggccc      300

tgctcgagtc agggctgagc aaagaggcac tgatccaggc actgggtgag ccggggccct      360

acctcctggc tggagaaggc cccctggaca agggggagtc ctgcggcggc ggtcgagggg      420

agctggctga gctgcccaat gggctggggg agactcgggg ctccgaggac gagacggacg      480

acgatgggga agacttcacg ccacccatcc tcaaagagct ggagaacctc agccctgagg      540

aggcggccca ccagaaagcc gtggtggaga cccttctgca ggaggacccg tggcgtgtgg      600

cgaagatggt caagtcctac ctgcagcagc acaacatccc acagcgggag gtggtcgata      660

ccactggcct caaccagtcc cacctgtccc aacacctcaa caagggcact cccatgaaga      720

cgcagaagcg ggccgccctg tacacctggt acgtccgcaa gcagcgagag gtggcgcagc      780

agttcaccca tgcagggcag ggagggctga ttgaagagcc cacaggtgat gagctaccaa      840

ccaagaaggg gcggaggaac cgtttcaagt ggggcccagc atcccagcag atcctgttcc      900

aggcctatga gaggcagaag aaccctagca aggaggagcg agagacgcta gtggaggagt      960

gcaatagggc ggaatgcatc cagagagggg tgtccccatc acaggcacag gggctgggct     1020

ccaacctcgt cacggaggtg cgtgtctaca actggtttgc caaccggcgc aaagaagaag     1080

ccttccggca caagctggcc atggacacgt acagcgggcc ccccccaggg ccaggcccgg     1140

gacctgcgct gcccgctcac agctcccctg gcctgcctcc acctgccctc tcccccagta     1200

aggtccacgg tgtgcgctat ggacagcctg cgaccagtga gactgcagaa gtaccctcaa     1260

gcagcggcgg tcccttagtg acagtgtcta cacccctcca ccaagtgtcc cccacgggcc     1320

tggagcccag ccacagcctg ctgagtacag aagccaagct ggtctcagca gctgggggcc     1380

ccctcccccc tgtcagcacc ctgacagcac tgcacagctt ggagcagaca tccccaggcc     1440

tcaaccagca gccccagaac ctcatcatgg cctcacttcc tggggtcatg accatcgggc     1500

ctggtgagcc tgcctccctg ggtcctacgt tcaccaacac aggtgcctcc accctggtca     1560

tcggcctggc ctccacgcag gcacagagtg tgccggtcat caacagcatg ggcagcagcc     1620

tgaccaccct gcagcccgtc cagttctccc agccgctgca cccctcctac cagcagccgc     1680

tcatgccacc tgtgcagagc catgtgaccc agagcccctt catggccacc atggctcagc     1740

tgcagagccc ccacgccctc tacagccaca agcccgaggt ggcccagtac acccacacgg     1800

gcctgctccc gcagactatg ctcatcaccg acaccaccaa cctgagcgcc ctggccagcc     1860

tcacgcccac caagcaggta aggtccaggc ctgctggccc tcccttggcc tgtgacagag     1920

cccctcaccc ccacatcccc cgggctcagg aggctgctct gctcccccag gtcttcacct     1980

cagacactga ggcctccagt gagtccgggc ttcacacgcc ggcatctcag gccaccaccc     2040

tccacgtccc cagccaggac cctgccagca tccagcacct gcagccggcc caccggctca     2100

gcgccagccc cacagtgtcc tccagcagcc tggtgctgta ccagagctca gactccagca     2160

atggccagag ccacctgctg ccatccaacc acagcgtcat cgagaccttc atctccaccc     2220

agatggcctc ttcctcccag taaccacggc acctgggccc tggggcctgt actgcctgct     2280

tggggggtga tgagggcagc agccagccct gcctggagga cctgagcctg ccgagcaacc     2340

gtggcccttc ctggacagct gtgcctcgct ccccactctg ctctgatgca tcagaaaggg     2400

agggctctga ggcgccccaa cccgtggagg ctgctcgggg tgcacaggag ggggtcgtgg     2460

agagctagga gcaaagcctg ttcatggcag atgtaggagg gactgtcgct gcttcgtggg     2520

atacagtctt cttacttgga actgaagggg gcggcctatg acttgggcac ccccagcctg     2580

ggcctatgga gagccctggg accgctacac cactctggca gccacacttc tcaggacaca     2640

ggcctgtgta gctgtgacct gctgagctct gagaggccct ggatcagcgt ggccttgttc     2700

tgtcaccaat gtacccaccg ggccactcct tcctgcccca actccttcca gctagtgacc     2760

cacatgccat ttgtactgac cccatcacct actcacacag gcatttcctg ggtggctact     2820

ctgtgccaga gcctggggct ctaacgcctg agcccaggga ggccgaagct aacagggaag     2880

gcaggcaggg ctctcctggc ttcccatccc cagcgattcc ctctcccagg ccccatgacc     2940

tccagctttc ctgtatttgt tcccaagagc atcatgcctc tgaggccagc ctggcctcct     3000

gcctctactg ggaaggctac ttcggggctg ggaagtcgtc cttactcctg tgggagcctc     3060

gcaacccgtg ccaagtccag gtcctggtgg ggcagctcct ctgtctcgag cgccctgcag     3120

accctgccct tgtttggggc aggagtagct gagctcacaa ggcagcaagg cccgagcagc     3180

tgagcagggc cggggaactg gccaagctga ggtgcccagg agaagaaaga ggtgacccca     3240

gggcacagga gctacctgtg tggacaggac taacactcag aagcctgggg gcctggctgg     3300

ctgagggcag ttcgcagcca ccctgaggag tctgaggtcc tgagcactgc caggagggac     3360

aaaggagcct gtgaacccag gacaagcatg gtcccacatc cctgggcctg ctgctgagaa     3420

cctggccttc agtgtaccgc gtctaccctg ggattcagga aaaggcctgg ggtgacccgg     3480

caccccctgc agcttgtagc cagccggggc gagtggcacg tttatttaac ttttagtaaa     3540

gtcaaggaga aatgcggtgg aaa                                             3563


<210>  11
<211>  13
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence


<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  HNF1-alpha binding sequence

<400>  11
gttaatnatt aac                                                          13


<210>  12
<211>  551
<212>  PRT
<213>  Homo sapiens

<400>  12

Met Asp Glu Leu Phe Pro Leu Ile Phe Pro Ala Glu Pro Ala Gln Ala 
1               5                   10                  15      


Ser Gly Pro Tyr Val Glu Ile Ile Glu Gln Pro Lys Gln Arg Gly Met 
            20                  25                  30          


Arg Phe Arg Tyr Lys Cys Glu Gly Arg Ser Ala Gly Ser Ile Pro Gly 
        35                  40                  45              


Glu Arg Ser Thr Asp Thr Thr Lys Thr His Pro Thr Ile Lys Ile Asn 
    50                  55                  60                  


Gly Tyr Thr Gly Pro Gly Thr Val Arg Ile Ser Leu Val Thr Lys Asp 
65                  70                  75                  80  


Pro Pro His Arg Pro His Pro His Glu Leu Val Gly Lys Asp Cys Arg 
                85                  90                  95      


Asp Gly Phe Tyr Glu Ala Glu Leu Cys Pro Asp Arg Cys Ile His Ser 
            100                 105                 110         


Phe Gln Asn Leu Gly Ile Gln Cys Val Lys Lys Arg Asp Leu Glu Gln 
        115                 120                 125             


Ala Ile Ser Gln Arg Ile Gln Thr Asn Asn Asn Pro Phe Gln Val Pro 
    130                 135                 140                 


Ile Glu Glu Gln Arg Gly Asp Tyr Asp Leu Asn Ala Val Arg Leu Cys 
145                 150                 155                 160 


Phe Gln Val Thr Val Arg Asp Pro Ser Gly Arg Pro Leu Arg Leu Pro 
                165                 170                 175     


Pro Val Leu Ser His Pro Ile Phe Asp Asn Arg Ala Pro Asn Thr Ala 
            180                 185                 190         


Glu Leu Lys Ile Cys Arg Val Asn Arg Asn Ser Gly Ser Cys Leu Gly 
        195                 200                 205             


Gly Asp Glu Ile Phe Leu Leu Cys Asp Lys Val Gln Lys Glu Asp Ile 
    210                 215                 220                 


Glu Val Tyr Phe Thr Gly Pro Gly Trp Glu Ala Arg Gly Ser Phe Ser 
225                 230                 235                 240 


Gln Ala Asp Val His Arg Gln Val Ala Ile Val Phe Arg Thr Pro Pro 
                245                 250                 255     


Tyr Ala Asp Pro Ser Leu Gln Ala Pro Val Arg Val Ser Met Gln Leu 
            260                 265                 270         


Arg Arg Pro Ser Asp Arg Glu Leu Ser Glu Pro Met Glu Phe Gln Tyr 
        275                 280                 285             


Leu Pro Asp Thr Asp Asp Arg His Arg Ile Glu Glu Lys Arg Lys Arg 
    290                 295                 300                 


Thr Tyr Glu Thr Phe Lys Ser Ile Met Lys Lys Ser Pro Phe Ser Gly 
305                 310                 315                 320 


Pro Thr Asp Pro Arg Pro Pro Pro Arg Arg Ile Ala Val Pro Ser Arg 
                325                 330                 335     


Ser Ser Ala Ser Val Pro Lys Pro Ala Pro Gln Pro Tyr Pro Phe Thr 
            340                 345                 350         


Ser Ser Leu Ser Thr Ile Asn Tyr Asp Glu Phe Pro Thr Met Val Phe 
        355                 360                 365             


Pro Ser Gly Gln Ile Ser Gln Ala Ser Ala Leu Ala Pro Ala Pro Pro 
    370                 375                 380                 


Gln Val Leu Pro Gln Ala Pro Ala Pro Ala Pro Ala Pro Ala Met Val 
385                 390                 395                 400 


Ser Ala Leu Ala Gln Ala Pro Ala Pro Val Pro Val Leu Ala Pro Gly 
                405                 410                 415     


Pro Pro Gln Ala Val Ala Pro Pro Ala Pro Lys Pro Thr Gln Ala Gly 
            420                 425                 430         


Glu Gly Thr Leu Ser Glu Ala Leu Leu Gln Leu Gln Phe Asp Asp Glu 
        435                 440                 445             


Asp Leu Gly Ala Leu Leu Gly Asn Ser Thr Asp Pro Ala Val Phe Thr 
    450                 455                 460                 


Asp Leu Ala Ser Val Asp Asn Ser Glu Phe Gln Gln Leu Leu Asn Gln 
465                 470                 475                 480 


Gly Ile Pro Val Ala Pro His Thr Thr Glu Pro Met Leu Met Glu Tyr 
                485                 490                 495     


Pro Glu Ala Ile Thr Arg Leu Val Thr Gly Ala Gln Arg Pro Pro Asp 
            500                 505                 510         


Pro Ala Pro Ala Pro Leu Gly Ala Pro Gly Leu Pro Asn Gly Leu Leu 
        515                 520                 525             


Ser Gly Asp Glu Asp Phe Ser Ser Ile Ala Asp Met Asp Phe Ser Ala 
    530                 535                 540                 


Leu Leu Ser Gln Ile Ser Ser 
545                 550     


<210>  13
<211>  548
<212>  PRT
<213>  Homo sapiens

<400>  13

Met Asp Glu Leu Phe Pro Leu Ile Phe Pro Ala Glu Pro Ala Gln Ala 
1               5                   10                  15      


Ser Gly Pro Tyr Val Glu Ile Ile Glu Gln Pro Lys Gln Arg Gly Met 
            20                  25                  30          


Arg Phe Arg Tyr Lys Cys Glu Gly Arg Ser Ala Gly Ser Ile Pro Gly 
        35                  40                  45              


Glu Arg Ser Thr Asp Thr Thr Lys Thr His Pro Thr Ile Lys Ile Asn 
    50                  55                  60                  


Gly Tyr Thr Gly Pro Gly Thr Val Arg Ile Ser Leu Val Thr Lys Asp 
65                  70                  75                  80  


Pro Pro His Arg Pro His Pro His Glu Leu Val Gly Lys Asp Cys Arg 
                85                  90                  95      


Asp Gly Phe Tyr Glu Ala Glu Leu Cys Pro Asp Arg Cys Ile His Ser 
            100                 105                 110         


Phe Gln Asn Leu Gly Ile Gln Cys Val Lys Lys Arg Asp Leu Glu Gln 
        115                 120                 125             


Ala Ile Ser Gln Arg Ile Gln Thr Asn Asn Asn Pro Phe Gln Glu Glu 
    130                 135                 140                 


Gln Arg Gly Asp Tyr Asp Leu Asn Ala Val Arg Leu Cys Phe Gln Val 
145                 150                 155                 160 


Thr Val Arg Asp Pro Ser Gly Arg Pro Leu Arg Leu Pro Pro Val Leu 
                165                 170                 175     


Ser His Pro Ile Phe Asp Asn Arg Ala Pro Asn Thr Ala Glu Leu Lys 
            180                 185                 190         


Ile Cys Arg Val Asn Arg Asn Ser Gly Ser Cys Leu Gly Gly Asp Glu 
        195                 200                 205             


Ile Phe Leu Leu Cys Asp Lys Val Gln Lys Glu Asp Ile Glu Val Tyr 
    210                 215                 220                 


Phe Thr Gly Pro Gly Trp Glu Ala Arg Gly Ser Phe Ser Gln Ala Asp 
225                 230                 235                 240 


Val His Arg Gln Val Ala Ile Val Phe Arg Thr Pro Pro Tyr Ala Asp 
                245                 250                 255     


Pro Ser Leu Gln Ala Pro Val Arg Val Ser Met Gln Leu Arg Arg Pro 
            260                 265                 270         


Ser Asp Arg Glu Leu Ser Glu Pro Met Glu Phe Gln Tyr Leu Pro Asp 
        275                 280                 285             


Thr Asp Asp Arg His Arg Ile Glu Glu Lys Arg Lys Arg Thr Tyr Glu 
    290                 295                 300                 


Thr Phe Lys Ser Ile Met Lys Lys Ser Pro Phe Ser Gly Pro Thr Asp 
305                 310                 315                 320 


Pro Arg Pro Pro Pro Arg Arg Ile Ala Val Pro Ser Arg Ser Ser Ala 
                325                 330                 335     


Ser Val Pro Lys Pro Ala Pro Gln Pro Tyr Pro Phe Thr Ser Ser Leu 
            340                 345                 350         


Ser Thr Ile Asn Tyr Asp Glu Phe Pro Thr Met Val Phe Pro Ser Gly 
        355                 360                 365             


Gln Ile Ser Gln Ala Ser Ala Leu Ala Pro Ala Pro Pro Gln Val Leu 
    370                 375                 380                 


Pro Gln Ala Pro Ala Pro Ala Pro Ala Pro Ala Met Val Ser Ala Leu 
385                 390                 395                 400 


Ala Gln Ala Pro Ala Pro Val Pro Val Leu Ala Pro Gly Pro Pro Gln 
                405                 410                 415     


Ala Val Ala Pro Pro Ala Pro Lys Pro Thr Gln Ala Gly Glu Gly Thr 
            420                 425                 430         


Leu Ser Glu Ala Leu Leu Gln Leu Gln Phe Asp Asp Glu Asp Leu Gly 
        435                 440                 445             


Ala Leu Leu Gly Asn Ser Thr Asp Pro Ala Val Phe Thr Asp Leu Ala 
    450                 455                 460                 


Ser Val Asp Asn Ser Glu Phe Gln Gln Leu Leu Asn Gln Gly Ile Pro 
465                 470                 475                 480 


Val Ala Pro His Thr Thr Glu Pro Met Leu Met Glu Tyr Pro Glu Ala 
                485                 490                 495     


Ile Thr Arg Leu Val Thr Gly Ala Gln Arg Pro Pro Asp Pro Ala Pro 
            500                 505                 510         


Ala Pro Leu Gly Ala Pro Gly Leu Pro Asn Gly Leu Leu Ser Gly Asp 
        515                 520                 525             


Glu Asp Phe Ser Ser Ile Ala Asp Met Asp Phe Ser Ala Leu Leu Ser 
    530                 535                 540                 


Gln Ile Ser Ser 
545             


<210>  14
<211>  482
<212>  PRT
<213>  Homo sapiens

<400>  14

Met Asp Glu Leu Phe Pro Leu Ile Phe Pro Ala Glu Pro Ala Gln Ala 
1               5                   10                  15      


Ser Gly Pro Tyr Val Glu Ile Ile Glu Gln Pro Lys Gln Arg Gly Met 
            20                  25                  30          


Arg Phe Arg Tyr Lys Cys Glu Gly Arg Ser Ala Gly Ser Ile Pro Gly 
        35                  40                  45              


Glu Arg Ser Thr Asp Thr Thr Lys Thr His Pro Thr Ile Lys Ile Asn 
    50                  55                  60                  


Gly Tyr Thr Gly Pro Gly Thr Val Arg Ile Ser Leu Val Thr Lys Asp 
65                  70                  75                  80  


Pro Pro His Arg Pro His Pro His Glu Leu Val Gly Lys Asp Cys Arg 
                85                  90                  95      


Asp Gly Phe Tyr Glu Ala Glu Leu Cys Pro Asp Arg Cys Ile His Ser 
            100                 105                 110         


Phe Gln Asn Leu Gly Ile Gln Cys Val Lys Lys Arg Asp Leu Glu Gln 
        115                 120                 125             


Ala Ile Ser Gln Arg Ile Gln Thr Asn Asn Asn Pro Phe Gln Val Pro 
    130                 135                 140                 


Ile Glu Glu Gln Arg Gly Asp Tyr Asp Leu Asn Ala Val Arg Leu Cys 
145                 150                 155                 160 


Phe Gln Val Thr Val Arg Asp Pro Ser Gly Arg Pro Leu Arg Leu Pro 
                165                 170                 175     


Pro Val Leu Ser His Pro Ile Phe Asp Asn Arg Ala Pro Asn Thr Ala 
            180                 185                 190         


Glu Leu Lys Ile Cys Arg Val Asn Arg Asn Ser Gly Ser Cys Leu Gly 
        195                 200                 205             


Gly Asp Glu Ile Phe Leu Leu Cys Asp Lys Val Gln Lys Glu Asp Ile 
    210                 215                 220                 


Glu Val Tyr Phe Thr Gly Pro Gly Trp Glu Ala Arg Gly Ser Phe Ser 
225                 230                 235                 240 


Gln Ala Asp Val His Arg Gln Val Ala Ile Val Phe Arg Thr Pro Pro 
                245                 250                 255     


Tyr Ala Asp Pro Ser Leu Gln Ala Pro Val Arg Val Ser Met Gln Leu 
            260                 265                 270         


Arg Arg Pro Ser Asp Arg Glu Leu Ser Glu Pro Met Glu Phe Gln Tyr 
        275                 280                 285             


Leu Pro Asp Thr Asp Asp Arg His Arg Ile Glu Glu Lys Arg Lys Arg 
    290                 295                 300                 


Thr Tyr Glu Thr Phe Lys Ser Ile Met Lys Lys Ser Pro Phe Ser Gly 
305                 310                 315                 320 


Pro Thr Asp Pro Arg Pro Pro Pro Arg Arg Ile Ala Val Pro Ser Arg 
                325                 330                 335     


Ser Ser Ala Ser Val Pro Lys Pro Ala Pro Gly Pro Pro Gln Ala Val 
            340                 345                 350         


Ala Pro Pro Ala Pro Lys Pro Thr Gln Ala Gly Glu Gly Thr Leu Ser 
        355                 360                 365             


Glu Ala Leu Leu Gln Leu Gln Phe Asp Asp Glu Asp Leu Gly Ala Leu 
    370                 375                 380                 


Leu Gly Asn Ser Thr Asp Pro Ala Val Phe Thr Asp Leu Ala Ser Val 
385                 390                 395                 400 


Asp Asn Ser Glu Phe Gln Gln Leu Leu Asn Gln Gly Ile Pro Val Ala 
                405                 410                 415     


Pro His Thr Thr Glu Pro Met Leu Met Glu Tyr Pro Glu Ala Ile Thr 
            420                 425                 430         


Arg Leu Val Thr Gly Ala Gln Arg Pro Pro Asp Pro Ala Pro Ala Pro 
        435                 440                 445             


Leu Gly Ala Pro Gly Leu Pro Asn Gly Leu Leu Ser Gly Asp Glu Asp 
    450                 455                 460                 


Phe Ser Ser Ile Ala Asp Met Asp Phe Ser Ala Leu Leu Ser Gln Ile 
465                 470                 475                 480 


Ser Ser 
        


<210>  15
<211>  448
<212>  PRT
<213>  Homo sapiens

<400>  15

Met Asp Glu Leu Phe Pro Leu Ile Phe Pro Ala Glu Pro Ala Gln Ala 
1               5                   10                  15      


Ser Gly Pro Tyr Val Glu Ile Ile Glu Gln Pro Lys Gln Arg Gly Met 
            20                  25                  30          


Arg Phe Arg Tyr Lys Cys Glu Gly Arg Ser Ala Gly Ser Ile Pro Gly 
        35                  40                  45              


Glu Arg Ser Thr Asp Thr Thr Lys Thr His Pro Thr Ile Lys Ile Asn 
    50                  55                  60                  


Gly Tyr Thr Gly Pro Gly Thr Val Arg Ile Ser Leu Val Thr Lys Asp 
65                  70                  75                  80  


Pro Pro His Arg Pro His Pro His Glu Leu Val Gly Lys Asp Cys Arg 
                85                  90                  95      


Asp Gly Phe Tyr Glu Ala Glu Leu Cys Pro Asp Arg Cys Ile His Ser 
            100                 105                 110         


Phe Gln Asn Leu Gly Ile Gln Cys Val Lys Lys Arg Asp Leu Glu Gln 
        115                 120                 125             


Ala Ile Ser Gln Arg Ile Gln Thr Asn Asn Asn Pro Phe Gln Val Pro 
    130                 135                 140                 


Ile Glu Glu Gln Arg Gly Asp Tyr Asp Leu Asn Ala Val Arg Leu Cys 
145                 150                 155                 160 


Phe Gln Val Thr Val Arg Asp Pro Ser Gly Arg Pro Leu Arg Leu Pro 
                165                 170                 175     


Pro Val Leu Ser His Pro Ile Phe Asp Asn Arg Ala Pro Asn Thr Ala 
            180                 185                 190         


Glu Leu Lys Ile Cys Arg Val Asn Arg Asn Ser Gly Ser Cys Leu Gly 
        195                 200                 205             


Gly Asp Glu Ile Phe Leu Leu Cys Asp Lys Val Gln Lys Glu Asp Ile 
    210                 215                 220                 


Glu Val Tyr Phe Thr Gly Pro Gly Trp Glu Ala Arg Gly Ser Phe Ser 
225                 230                 235                 240 


Gln Ala Asp Val His Arg Gln Val Ala Ile Val Phe Arg Thr Pro Pro 
                245                 250                 255     


Tyr Ala Asp Pro Ser Leu Gln Ala Pro Val Arg Val Ser Met Gln Leu 
            260                 265                 270         


Arg Arg Pro Ser Asp Arg Glu Leu Ser Glu Pro Met Glu Phe Gln Tyr 
        275                 280                 285             


Leu Pro Asp Thr Asp Asp Arg His Arg Ile Glu Glu Lys Arg Lys Arg 
    290                 295                 300                 


Thr Tyr Glu Thr Phe Lys Ser Ile Met Lys Lys Ser Pro Phe Ser Gly 
305                 310                 315                 320 


Pro Thr Asp Pro Arg Pro Pro Pro Arg Arg Ile Ala Val Pro Ser Arg 
                325                 330                 335     


Ser Ser Ala Ser Val Pro Lys Pro Ala Pro Gln Pro Tyr Pro Phe Thr 
            340                 345                 350         


Ser Ser Leu Ser Thr Ile Asn Tyr Asp Glu Phe Pro Thr Met Val Phe 
        355                 360                 365             


Pro Ser Gly Gln Ile Ser Gln Ala Ser Ala Leu Ala Pro Ala Pro Pro 
    370                 375                 380                 


Gln Val Leu Pro Gln Ala Pro Ala Pro Ala Pro Ala Pro Ala Met Val 
385                 390                 395                 400 


Ser Ala Leu Ala Gln Arg Pro Pro Asp Pro Ala Pro Ala Pro Leu Gly 
                405                 410                 415     


Ala Pro Gly Leu Pro Asn Gly Leu Leu Ser Gly Asp Glu Asp Phe Ser 
            420                 425                 430         


Ser Ile Ala Asp Met Asp Phe Ser Ala Leu Leu Ser Gln Ile Ser Ser 
        435                 440                 445             


<210>  16
<211>  480
<212>  PRT
<213>  Homo sapiens

<400>  16

Met Asp Glu Leu Phe Pro Leu Ile Phe Pro Ala Glu Pro Ala Gln Ala 
1               5                   10                  15      


Ser Gly Pro Tyr Val Glu Ile Ile Glu Gln Pro Lys Gln Arg Gly Met 
            20                  25                  30          


Arg Phe Arg Tyr Lys Cys Glu Gly Arg Ser Ala Gly Ser Ile Pro Gly 
        35                  40                  45              


Glu Arg Ser Thr Asp Thr Thr Lys Thr His Pro Thr Ile Lys Ile Asn 
    50                  55                  60                  


Gly Tyr Thr Gly Pro Gly Thr Val Arg Ile Ser Leu Val Thr Lys Asp 
65                  70                  75                  80  


Pro Pro His Arg Pro His Pro His Glu Leu Val Gly Lys Asp Cys Arg 
                85                  90                  95      


Asp Gly Phe Tyr Glu Ala Glu Leu Cys Pro Asp Arg Cys Ile His Ser 
            100                 105                 110         


Phe Gln Asn Leu Gly Ile Gln Cys Val Lys Lys Arg Asp Leu Glu Gln 
        115                 120                 125             


Ala Ile Ser Gln Arg Ile Gln Thr Asn Asn Asn Pro Phe Gln Val Pro 
    130                 135                 140                 


Ile Glu Glu Gln Arg Gly Asp Tyr Asp Leu Asn Ala Val Arg Leu Cys 
145                 150                 155                 160 


Phe Gln Val Thr Val Arg Asp Pro Ser Gly Arg Pro Leu Arg Leu Pro 
                165                 170                 175     


Pro Val Leu Ser His Pro Ile Phe Asp Asn Arg Ala Pro Asn Thr Ala 
            180                 185                 190         


Glu Leu Lys Ile Cys Arg Val Asn Arg Asn Ser Gly Ser Cys Leu Gly 
        195                 200                 205             


Gly Asp Glu Ile Phe Leu Leu Cys Asp Lys Val Gln Lys Asp Asp Arg 
    210                 215                 220                 


His Arg Ile Glu Glu Lys Arg Lys Arg Thr Tyr Glu Thr Phe Lys Ser 
225                 230                 235                 240 


Ile Met Lys Lys Ser Pro Phe Ser Gly Pro Thr Asp Pro Arg Pro Pro 
                245                 250                 255     


Pro Arg Arg Ile Ala Val Pro Ser Arg Ser Ser Ala Ser Val Pro Lys 
            260                 265                 270         


Pro Ala Pro Gln Pro Tyr Pro Phe Thr Ser Ser Leu Ser Thr Ile Asn 
        275                 280                 285             


Tyr Asp Glu Phe Pro Thr Met Val Phe Pro Ser Gly Gln Ile Ser Gln 
    290                 295                 300                 


Ala Ser Ala Leu Ala Pro Ala Pro Pro Gln Val Leu Pro Gln Ala Pro 
305                 310                 315                 320 


Ala Pro Ala Pro Ala Pro Ala Met Val Ser Ala Leu Ala Gln Ala Pro 
                325                 330                 335     


Ala Pro Val Pro Val Leu Ala Pro Gly Pro Pro Gln Ala Val Ala Pro 
            340                 345                 350         


Pro Ala Pro Lys Pro Thr Gln Ala Gly Glu Gly Thr Leu Ser Glu Ala 
        355                 360                 365             


Leu Leu Gln Leu Gln Phe Asp Asp Glu Asp Leu Gly Ala Leu Leu Gly 
    370                 375                 380                 


Asn Ser Thr Asp Pro Ala Val Phe Thr Asp Leu Ala Ser Val Asp Asn 
385                 390                 395                 400 


Ser Glu Phe Gln Gln Leu Leu Asn Gln Gly Ile Pro Val Ala Pro His 
                405                 410                 415     


Thr Thr Glu Pro Met Leu Met Glu Tyr Pro Glu Ala Ile Thr Arg Leu 
            420                 425                 430         


Val Thr Gly Ala Gln Arg Pro Pro Asp Pro Ala Pro Ala Pro Leu Gly 
        435                 440                 445             


Ala Pro Gly Leu Pro Asn Gly Leu Leu Ser Gly Asp Glu Asp Phe Ser 
    450                 455                 460                 


Ser Ile Ala Asp Met Asp Phe Ser Ala Leu Leu Ser Gln Ile Ser Ser 
465                 470                 475                 480 


<210>  17
<211>  445
<212>  PRT
<213>  Homo sapiens

<400>  17

Met Asp Glu Leu Phe Pro Leu Ile Phe Pro Ala Glu Pro Ala Gln Ala 
1               5                   10                  15      


Ser Gly Pro Tyr Val Glu Ile Ile Glu Gln Pro Lys Gln Arg Gly Met 
            20                  25                  30          


Arg Phe Arg Tyr Lys Cys Glu Gly Arg Ser Ala Gly Ser Ile Pro Gly 
        35                  40                  45              


Glu Arg Ser Thr Asp Thr Thr Lys Thr His Pro Thr Ile Lys Ile Asn 
    50                  55                  60                  


Gly Tyr Thr Gly Pro Gly Thr Val Arg Ile Ser Leu Val Thr Lys Asp 
65                  70                  75                  80  


Pro Pro His Arg Pro His Pro His Glu Leu Val Gly Lys Asp Cys Arg 
                85                  90                  95      


Asp Gly Phe Tyr Glu Ala Glu Leu Cys Pro Asp Arg Cys Ile His Ser 
            100                 105                 110         


Phe Gln Asn Leu Gly Ile Gln Cys Val Lys Lys Arg Asp Leu Glu Gln 
        115                 120                 125             


Ala Ile Ser Gln Arg Ile Gln Thr Asn Asn Asn Pro Phe Gln Val Pro 
    130                 135                 140                 


Ile Glu Glu Gln Arg Gly Asp Tyr Asp Leu Asn Ala Val Arg Leu Cys 
145                 150                 155                 160 


Phe Gln Val Thr Val Arg Asp Pro Ser Gly Arg Pro Leu Arg Leu Pro 
                165                 170                 175     


Pro Val Leu Ser His Pro Ile Phe Asp Asn His Asp Arg His Arg Ile 
            180                 185                 190         


Glu Glu Lys Arg Lys Arg Thr Tyr Glu Thr Phe Lys Ser Ile Met Lys 
        195                 200                 205             


Lys Ser Pro Phe Ser Gly Pro Thr Asp Pro Arg Pro Pro Pro Arg Arg 
    210                 215                 220                 


Ile Ala Val Pro Ser Arg Ser Ser Ala Ser Val Pro Lys Pro Ala Pro 
225                 230                 235                 240 


Gln Pro Tyr Pro Phe Thr Ser Ser Leu Ser Thr Ile Asn Tyr Asp Glu 
                245                 250                 255     


Phe Pro Thr Met Val Phe Pro Ser Gly Gln Ile Ser Gln Ala Ser Ala 
            260                 265                 270         


Leu Ala Pro Ala Pro Pro Gln Val Leu Pro Gln Ala Pro Ala Pro Ala 
        275                 280                 285             


Pro Ala Pro Ala Met Val Ser Ala Leu Ala Gln Ala Pro Ala Pro Val 
    290                 295                 300                 


Pro Val Leu Ala Pro Gly Pro Pro Gln Ala Val Ala Pro Pro Ala Pro 
305                 310                 315                 320 


Lys Pro Thr Gln Ala Gly Glu Gly Thr Leu Ser Glu Ala Leu Leu Gln 
                325                 330                 335     


Leu Gln Phe Asp Asp Glu Asp Leu Gly Ala Leu Leu Gly Asn Ser Thr 
            340                 345                 350         


Asp Pro Ala Val Phe Thr Asp Leu Ala Ser Val Asp Asn Ser Glu Phe 
        355                 360                 365             


Gln Gln Leu Leu Asn Gln Gly Ile Pro Val Ala Pro His Thr Thr Glu 
    370                 375                 380                 


Pro Met Leu Met Glu Tyr Pro Glu Ala Ile Thr Arg Leu Val Thr Gly 
385                 390                 395                 400 


Ala Gln Arg Pro Pro Asp Pro Ala Pro Ala Pro Leu Gly Ala Pro Gly 
                405                 410                 415     


Leu Pro Asn Gly Leu Leu Ser Gly Asp Glu Asp Phe Ser Ser Ile Ala 
            420                 425                 430         


Asp Met Asp Phe Ser Ala Leu Leu Ser Gln Ile Ser Ser 
        435                 440                 445 


<210>  18
<211>  2595
<212>  DNA
<213>  Homo sapiens

<400>  18
agcgcgcagg cgcggccgga ttccgggcag tgacgcgacg gcgggccgcg cggcgcattt       60

ccgcctctgg cgaatggctc gtctgtagtg cacgccgcgg gcccagctgc gaccccggcc      120

ccgcccccgg gaccccggcc atggacgaac tgttccccct catcttcccg gcagagccag      180

cccaggcctc tggcccctat gtggagatca ttgagcagcc caagcagcgg ggcatgcgct      240

tccgctacaa gtgcgagggg cgctccgcgg gcagcatccc aggcgagagg agcacagata      300

ccaccaagac ccaccccacc atcaagatca atggctacac aggaccaggg acagtgcgca      360

tctccctggt caccaaggac cctcctcacc ggcctcaccc ccacgagctt gtaggaaagg      420

actgccggga tggcttctat gaggctgagc tctgcccgga ccgctgcatc cacagtttcc      480

agaacctggg aatccagtgt gtgaagaagc gggacctgga gcaggctatc agtcagcgca      540

tccagaccaa caacaacccc ttccaagttc ctatagaaga gcagcgtggg gactacgacc      600

tgaatgctgt gcggctctgc ttccaggtga cagtgcggga cccatcaggc aggcccctcc      660

gcctgccgcc tgtcctttct catcccatct ttgacaatcg tgcccccaac actgccgagc      720

tcaagatctg ccgagtgaac cgaaactctg gcagctgcct cggtggggat gagatcttcc      780

tactgtgtga caaggtgcag aaagaggaca ttgaggtgta tttcacggga ccaggctggg      840

aggcccgagg ctccttttcg caagctgatg tgcaccgaca agtggccatt gtgttccgga      900

cccctcccta cgcagacccc agcctgcagg ctcctgtgcg tgtctccatg cagctgcggc      960

ggccttccga ccgggagctc agtgagccca tggaattcca gtacctgcca gatacagacg     1020

atcgtcaccg gattgaggag aaacgtaaaa ggacatatga gaccttcaag agcatcatga     1080

agaagagtcc tttcagcgga cccaccgacc cccggcctcc acctcgacgc attgctgtgc     1140

cttcccgcag ctcagcttct gtccccaagc cagcacccca gccctatccc tttacgtcat     1200

ccctgagcac catcaactat gatgagtttc ccaccatggt gtttccttct gggcagatca     1260

gccaggcctc ggccttggcc ccggcccctc cccaagtcct gccccaggct ccagcccctg     1320

cccctgctcc agccatggta tcagctctgg cccaggcccc agcccctgtc ccagtcctag     1380

ccccaggccc tcctcaggct gtggccccac ctgcccccaa gcccacccag gctggggaag     1440

gaacgctgtc agaggccctg ctgcagctgc agtttgatga tgaagacctg ggggccttgc     1500

ttggcaacag cacagaccca gctgtgttca cagacctggc atccgtcgac aactccgagt     1560

ttcagcagct gctgaaccag ggcatacctg tggcccccca cacaactgag cccatgctga     1620

tggagtaccc tgaggctata actcgcctag tgacaggggc ccagaggccc cccgacccag     1680

ctcctgctcc actgggggcc ccggggctcc ccaatggcct cctttcagga gatgaagact     1740

tctcctccat tgcggacatg gacttctcag ccctgctgag tcagatcagc tcctaagggg     1800

gtgacgcctg ccctccccag agcactgggt tgcaggggat tgaagccctc caaaagcact     1860

tacggattct ggtggggtgt gttccaactg cccccaactt tgtggatgtc ttccttggag     1920

gggggagcca tattttattc ttttattgtc agtatctgta tctctctctc tttttggagg     1980

tgcttaagca gaagcattaa cttctctgga aaggggggag ctggggaaac tcaaactttt     2040

cccctgtcct gatggtcagc tcccttctct gtagggaact ctggggtccc ccatccccat     2100

cctccagctt ctggtactct cctagagaca gaagcaggct ggaggtaagg cctttgagcc     2160

cacaaagcct tatcaagtgt cttccatcat ggattcatta cagcttaatc aaaataacgc     2220

cccagatacc agcccctgta tggcactggc attgtccctg tgcctaacac cagcgtttga     2280

ggggctggcc ttcctgccct acagaggtct ctgccggctc tttccttgct caaccatggc     2340

tgaaggaaac cagtgcaaca gcactggctc tctccaggat ccagaagggg tttggtctgg     2400

gacttccttg ctctccctct tctcaagtgc cttaatagta gggtaagttg ttaagagtgg     2460

gggagagcag gctggcagct ctccagtcag gaggcatagt ttttactgaa caatcaaagc     2520

acttggactc ttgctctttc tactctgaac taataaatct gttgccaagc tggctagaaa     2580

aaaaaaaaaa aaaaa                                                      2595


<210>  19
<211>  2586
<212>  DNA
<213>  Homo sapiens

<400>  19
agcgcgcagg cgcggccgga ttccgggcag tgacgcgacg gcgggccgcg cggcgcattt       60

ccgcctctgg cgaatggctc gtctgtagtg cacgccgcgg gcccagctgc gaccccggcc      120

ccgcccccgg gaccccggcc atggacgaac tgttccccct catcttcccg gcagagccag      180

cccaggcctc tggcccctat gtggagatca ttgagcagcc caagcagcgg ggcatgcgct      240

tccgctacaa gtgcgagggg cgctccgcgg gcagcatccc aggcgagagg agcacagata      300

ccaccaagac ccaccccacc atcaagatca atggctacac aggaccaggg acagtgcgca      360

tctccctggt caccaaggac cctcctcacc ggcctcaccc ccacgagctt gtaggaaagg      420

actgccggga tggcttctat gaggctgagc tctgcccgga ccgctgcatc cacagtttcc      480

agaacctggg aatccagtgt gtgaagaagc gggacctgga gcaggctatc agtcagcgca      540

tccagaccaa caacaacccc ttccaagaag agcagcgtgg ggactacgac ctgaatgctg      600

tgcggctctg cttccaggtg acagtgcggg acccatcagg caggcccctc cgcctgccgc      660

ctgtcctttc tcatcccatc tttgacaatc gtgcccccaa cactgccgag ctcaagatct      720

gccgagtgaa ccgaaactct ggcagctgcc tcggtgggga tgagatcttc ctactgtgtg      780

acaaggtgca gaaagaggac attgaggtgt atttcacggg accaggctgg gaggcccgag      840

gctccttttc gcaagctgat gtgcaccgac aagtggccat tgtgttccgg acccctccct      900

acgcagaccc cagcctgcag gctcctgtgc gtgtctccat gcagctgcgg cggccttccg      960

accgggagct cagtgagccc atggaattcc agtacctgcc agatacagac gatcgtcacc     1020

ggattgagga gaaacgtaaa aggacatatg agaccttcaa gagcatcatg aagaagagtc     1080

ctttcagcgg acccaccgac ccccggcctc cacctcgacg cattgctgtg ccttcccgca     1140

gctcagcttc tgtccccaag ccagcacccc agccctatcc ctttacgtca tccctgagca     1200

ccatcaacta tgatgagttt cccaccatgg tgtttccttc tgggcagatc agccaggcct     1260

cggccttggc cccggcccct ccccaagtcc tgccccaggc tccagcccct gcccctgctc     1320

cagccatggt atcagctctg gcccaggccc cagcccctgt cccagtccta gccccaggcc     1380

ctcctcaggc tgtggcccca cctgccccca agcccaccca ggctggggaa ggaacgctgt     1440

cagaggccct gctgcagctg cagtttgatg atgaagacct gggggccttg cttggcaaca     1500

gcacagaccc agctgtgttc acagacctgg catccgtcga caactccgag tttcagcagc     1560

tgctgaacca gggcatacct gtggcccccc acacaactga gcccatgctg atggagtacc     1620

ctgaggctat aactcgccta gtgacagggg cccagaggcc ccccgaccca gctcctgctc     1680

cactgggggc cccggggctc cccaatggcc tcctttcagg agatgaagac ttctcctcca     1740

ttgcggacat ggacttctca gccctgctga gtcagatcag ctcctaaggg ggtgacgcct     1800

gccctcccca gagcactggg ttgcagggga ttgaagccct ccaaaagcac ttacggattc     1860

tggtggggtg tgttccaact gcccccaact ttgtggatgt cttccttgga ggggggagcc     1920

atattttatt cttttattgt cagtatctgt atctctctct ctttttggag gtgcttaagc     1980

agaagcatta acttctctgg aaagggggga gctggggaaa ctcaaacttt tcccctgtcc     2040

tgatggtcag ctcccttctc tgtagggaac tctggggtcc cccatcccca tcctccagct     2100

tctggtactc tcctagagac agaagcaggc tggaggtaag gcctttgagc ccacaaagcc     2160

ttatcaagtg tcttccatca tggattcatt acagcttaat caaaataacg ccccagatac     2220

cagcccctgt atggcactgg cattgtccct gtgcctaaca ccagcgtttg aggggctggc     2280

cttcctgccc tacagaggtc tctgccggct ctttccttgc tcaaccatgg ctgaaggaaa     2340

ccagtgcaac agcactggct ctctccagga tccagaaggg gtttggtctg ggacttcctt     2400

gctctccctc ttctcaagtg ccttaatagt agggtaagtt gttaagagtg ggggagagca     2460

ggctggcagc tctccagtca ggaggcatag tttttactga acaatcaaag cacttggact     2520

cttgctcttt ctactctgaa ctaataaatc tgttgccaag ctggctagaa aaaaaaaaaa     2580

aaaaaa                                                                2586


<210>  20
<211>  2388
<212>  DNA
<213>  Homo sapiens

<400>  20
agcgcgcagg cgcggccgga ttccgggcag tgacgcgacg gcgggccgcg cggcgcattt       60

ccgcctctgg cgaatggctc gtctgtagtg cacgccgcgg gcccagctgc gaccccggcc      120

ccgcccccgg gaccccggcc atggacgaac tgttccccct catcttcccg gcagagccag      180

cccaggcctc tggcccctat gtggagatca ttgagcagcc caagcagcgg ggcatgcgct      240

tccgctacaa gtgcgagggg cgctccgcgg gcagcatccc aggcgagagg agcacagata      300

ccaccaagac ccaccccacc atcaagatca atggctacac aggaccaggg acagtgcgca      360

tctccctggt caccaaggac cctcctcacc ggcctcaccc ccacgagctt gtaggaaagg      420

actgccggga tggcttctat gaggctgagc tctgcccgga ccgctgcatc cacagtttcc      480

agaacctggg aatccagtgt gtgaagaagc gggacctgga gcaggctatc agtcagcgca      540

tccagaccaa caacaacccc ttccaagttc ctatagaaga gcagcgtggg gactacgacc      600

tgaatgctgt gcggctctgc ttccaggtga cagtgcggga cccatcaggc aggcccctcc      660

gcctgccgcc tgtcctttct catcccatct ttgacaatcg tgcccccaac actgccgagc      720

tcaagatctg ccgagtgaac cgaaactctg gcagctgcct cggtggggat gagatcttcc      780

tactgtgtga caaggtgcag aaagaggaca ttgaggtgta tttcacggga ccaggctggg      840

aggcccgagg ctccttttcg caagctgatg tgcaccgaca agtggccatt gtgttccgga      900

cccctcccta cgcagacccc agcctgcagg ctcctgtgcg tgtctccatg cagctgcggc      960

ggccttccga ccgggagctc agtgagccca tggaattcca gtacctgcca gatacagacg     1020

atcgtcaccg gattgaggag aaacgtaaaa ggacatatga gaccttcaag agcatcatga     1080

agaagagtcc tttcagcgga cccaccgacc cccggcctcc acctcgacgc attgctgtgc     1140

cttcccgcag ctcagcttct gtccccaagc cagccccagg ccctcctcag gctgtggccc     1200

cacctgcccc caagcccacc caggctgggg aaggaacgct gtcagaggcc ctgctgcagc     1260

tgcagtttga tgatgaagac ctgggggcct tgcttggcaa cagcacagac ccagctgtgt     1320

tcacagacct ggcatccgtc gacaactccg agtttcagca gctgctgaac cagggcatac     1380

ctgtggcccc ccacacaact gagcccatgc tgatggagta ccctgaggct ataactcgcc     1440

tagtgacagg ggcccagagg ccccccgacc cagctcctgc tccactgggg gccccggggc     1500

tccccaatgg cctcctttca ggagatgaag acttctcctc cattgcggac atggacttct     1560

cagccctgct gagtcagatc agctcctaag ggggtgacgc ctgccctccc cagagcactg     1620

ggttgcaggg gattgaagcc ctccaaaagc acttacggat tctggtgggg tgtgttccaa     1680

ctgcccccaa ctttgtggat gtcttccttg gaggggggag ccatatttta ttcttttatt     1740

gtcagtatct gtatctctct ctctttttgg aggtgcttaa gcagaagcat taacttctct     1800

ggaaaggggg gagctgggga aactcaaact tttcccctgt cctgatggtc agctcccttc     1860

tctgtaggga actctggggt cccccatccc catcctccag cttctggtac tctcctagag     1920

acagaagcag gctggaggta aggcctttga gcccacaaag ccttatcaag tgtcttccat     1980

catggattca ttacagctta atcaaaataa cgccccagat accagcccct gtatggcact     2040

ggcattgtcc ctgtgcctaa caccagcgtt tgaggggctg gccttcctgc cctacagagg     2100

tctctgccgg ctctttcctt gctcaaccat ggctgaagga aaccagtgca acagcactgg     2160

ctctctccag gatccagaag gggtttggtc tgggacttcc ttgctctccc tcttctcaag     2220

tgccttaata gtagggtaag ttgttaagag tgggggagag caggctggca gctctccagt     2280

caggaggcat agtttttact gaacaatcaa agcacttgga ctcttgctct ttctactctg     2340

aactaataaa tctgttgcca agctggctag aaaaaaaaaa aaaaaaaa                  2388


<210>  21
<211>  2286
<212>  DNA
<213>  Homo sapiens

<400>  21
agcgcgcagg cgcggccgga ttccgggcag tgacgcgacg gcgggccgcg cggcgcattt       60

ccgcctctgg cgaatggctc gtctgtagtg cacgccgcgg gcccagctgc gaccccggcc      120

ccgcccccgg gaccccggcc atggacgaac tgttccccct catcttcccg gcagagccag      180

cccaggcctc tggcccctat gtggagatca ttgagcagcc caagcagcgg ggcatgcgct      240

tccgctacaa gtgcgagggg cgctccgcgg gcagcatccc aggcgagagg agcacagata      300

ccaccaagac ccaccccacc atcaagatca atggctacac aggaccaggg acagtgcgca      360

tctccctggt caccaaggac cctcctcacc ggcctcaccc ccacgagctt gtaggaaagg      420

actgccggga tggcttctat gaggctgagc tctgcccgga ccgctgcatc cacagtttcc      480

agaacctggg aatccagtgt gtgaagaagc gggacctgga gcaggctatc agtcagcgca      540

tccagaccaa caacaacccc ttccaagttc ctatagaaga gcagcgtggg gactacgacc      600

tgaatgctgt gcggctctgc ttccaggtga cagtgcggga cccatcaggc aggcccctcc      660

gcctgccgcc tgtcctttct catcccatct ttgacaatcg tgcccccaac actgccgagc      720

tcaagatctg ccgagtgaac cgaaactctg gcagctgcct cggtggggat gagatcttcc      780

tactgtgtga caaggtgcag aaagaggaca ttgaggtgta tttcacggga ccaggctggg      840

aggcccgagg ctccttttcg caagctgatg tgcaccgaca agtggccatt gtgttccgga      900

cccctcccta cgcagacccc agcctgcagg ctcctgtgcg tgtctccatg cagctgcggc      960

ggccttccga ccgggagctc agtgagccca tggaattcca gtacctgcca gatacagacg     1020

atcgtcaccg gattgaggag aaacgtaaaa ggacatatga gaccttcaag agcatcatga     1080

agaagagtcc tttcagcgga cccaccgacc cccggcctcc acctcgacgc attgctgtgc     1140

cttcccgcag ctcagcttct gtccccaagc cagcacccca gccctatccc tttacgtcat     1200

ccctgagcac catcaactat gatgagtttc ccaccatggt gtttccttct gggcagatca     1260

gccaggcctc ggccttggcc ccggcccctc cccaagtcct gccccaggct ccagcccctg     1320

cccctgctcc agccatggta tcagctctgg cccagaggcc ccccgaccca gctcctgctc     1380

cactgggggc cccggggctc cccaatggcc tcctttcagg agatgaagac ttctcctcca     1440

ttgcggacat ggacttctca gccctgctga gtcagatcag ctcctaaggg ggtgacgcct     1500

gccctcccca gagcactggg ttgcagggga ttgaagccct ccaaaagcac ttacggattc     1560

tggtggggtg tgttccaact gcccccaact ttgtggatgt cttccttgga ggggggagcc     1620

atattttatt cttttattgt cagtatctgt atctctctct ctttttggag gtgcttaagc     1680

agaagcatta acttctctgg aaagggggga gctggggaaa ctcaaacttt tcccctgtcc     1740

tgatggtcag ctcccttctc tgtagggaac tctggggtcc cccatcccca tcctccagct     1800

tctggtactc tcctagagac agaagcaggc tggaggtaag gcctttgagc ccacaaagcc     1860

ttatcaagtg tcttccatca tggattcatt acagcttaat caaaataacg ccccagatac     1920

cagcccctgt atggcactgg cattgtccct gtgcctaaca ccagcgtttg aggggctggc     1980

cttcctgccc tacagaggtc tctgccggct ctttccttgc tcaaccatgg ctgaaggaaa     2040

ccagtgcaac agcactggct ctctccagga tccagaaggg gtttggtctg ggacttcctt     2100

gctctccctc ttctcaagtg ccttaatagt agggtaagtt gttaagagtg ggggagagca     2160

ggctggcagc tctccagtca ggaggcatag tttttactga acaatcaaag cacttggact     2220

cttgctcttt ctactctgaa ctaataaatc tgttgccaag ctggctagaa aaaaaaaaaa     2280

aaaaaa                                                                2286


<210>  22
<211>  2341
<212>  DNA
<213>  Homo sapiens

<400>  22
attccgggca gtgacgcgac ggcgggccgc gcggcgcatt tccgcctctg gcgaatggct       60

cgtctgtagt gcacgccgcg ggcccagctg cgaccccggc cccgcccccg ggaccccggc      120

catggacgaa ctgttccccc tcatcttccc ggcagagcca gcccaggcct ctggccccta      180

tgtggagatc attgagcagc ccaagcagcg gggcatgcgc ttccgctaca agtgcgaggg      240

gcgctccgcg ggcagcatcc caggcgagag gagcacagat accaccaaga cccaccccac      300

catcaagatc aatggctaca caggaccagg gacagtgcgc atctccctgg tcaccaagga      360

ccctcctcac cggcctcacc cccacgagct tgtaggaaag gactgccggg atggcttcta      420

tgaggctgag ctctgcccgg accgctgcat ccacagtttc cagaacctgg gaatccagtg      480

tgtgaagaag cgggacctgg agcaggctat cagtcagcgc atccagacca acaacaaccc      540

cttccaagtt cctatagaag agcagcgtgg ggactacgac ctgaatgctg tgcggctctg      600

cttccaggtg acagtgcggg acccatcagg caggcccctc cgcctgccgc ctgtcctttc      660

tcatcccatc tttgacaatc gtgcccccaa cactgccgag ctcaagatct gccgagtgaa      720

ccgaaactct ggcagctgcc tcggtgggga tgagatcttc ctactgtgtg acaaggtgca      780

gaaagacgat cgtcaccgga ttgaggagaa acgtaaaagg acatatgaga ccttcaagag      840

catcatgaag aagagtcctt tcagcggacc caccgacccc cggcctccac ctcgacgcat      900

tgctgtgcct tcccgcagct cagcttctgt ccccaagcca gcaccccagc cctatccctt      960

tacgtcatcc ctgagcacca tcaactatga tgagtttccc accatggtgt ttccttctgg     1020

gcagatcagc caggcctcgg ccttggcccc ggcccctccc caagtcctgc cccaggctcc     1080

agcccctgcc cctgctccag ccatggtatc agctctggcc caggccccag cccctgtccc     1140

agtcctagcc ccaggccctc ctcaggctgt ggccccacct gcccccaagc ccacccaggc     1200

tggggaagga acgctgtcag aggccctgct gcagctgcag tttgatgatg aagacctggg     1260

ggccttgctt ggcaacagca cagacccagc tgtgttcaca gacctggcat ccgtcgacaa     1320

ctccgagttt cagcagctgc tgaaccaggg catacctgtg gccccccaca caactgagcc     1380

catgctgatg gagtaccctg aggctataac tcgcctagtg acaggggccc agaggccccc     1440

cgacccagct cctgctccac tgggggcccc ggggctcccc aatggcctcc tttcaggaga     1500

tgaagacttc tcctccattg cggacatgga cttctcagcc ctgctgagtc agatcagctc     1560

ctaagggggt gacgcctgcc ctccccagag cactgggttg caggggattg aagccctcca     1620

aaagcactta cggattctgg tggggtgtgt tccaactgcc cccaactttg tggatgtctt     1680

ccttggaggg gggagccata ttttattctt ttattgtcag tatctgtatc tctctctctt     1740

tttggaggtg cttaagcaga agcattaact tctctggaaa ggggggagct ggggaaactc     1800

aaacttttcc cctgtcctga tggtcagctc ccttctctgt agggaactct ggggtccccc     1860

atccccatcc tccagcttct ggtactctcc tagagacaga agcaggctgg aggtaaggcc     1920

tttgagccca caaagcctta tcaagtgtct tccatcatgg attcattaca gcttaatcaa     1980

aataacgccc cagataccag cccctgtatg gcactggcat tgtccctgtg cctaacacca     2040

gcgtttgagg ggctggcctt cctgccctac agaggtctct gccggctctt tccttgctca     2100

accatggctg aaggaaacca gtgcaacagc actggctctc tccaggatcc agaaggggtt     2160

tggtctggga cttccttgct ctccctcttc tcaagtgcct taatagtagg gtaagttgtt     2220

aagagtgggg gagagcaggc tggcagctct ccagtcagga ggcatagttt ttactgaaca     2280

atcaaagcac ttggactctt gctctttcta ctctgaacta ataaatctgt tgccaagctg     2340

g                                                                     2341


<210>  23
<211>  2236
<212>  DNA
<213>  Homo sapiens

<400>  23
attccgggca gtgacgcgac ggcgggccgc gcggcgcatt tccgcctctg gcgaatggct       60

cgtctgtagt gcacgccgcg ggcccagctg cgaccccggc cccgcccccg ggaccccggc      120

catggacgaa ctgttccccc tcatcttccc ggcagagcca gcccaggcct ctggccccta      180

tgtggagatc attgagcagc ccaagcagcg gggcatgcgc ttccgctaca agtgcgaggg      240

gcgctccgcg ggcagcatcc caggcgagag gagcacagat accaccaaga cccaccccac      300

catcaagatc aatggctaca caggaccagg gacagtgcgc atctccctgg tcaccaagga      360

ccctcctcac cggcctcacc cccacgagct tgtaggaaag gactgccggg atggcttcta      420

tgaggctgag ctctgcccgg accgctgcat ccacagtttc cagaacctgg gaatccagtg      480

tgtgaagaag cgggacctgg agcaggctat cagtcagcgc atccagacca acaacaaccc      540

cttccaagtt cctatagaag agcagcgtgg ggactacgac ctgaatgctg tgcggctctg      600

cttccaggtg acagtgcggg acccatcagg caggcccctc cgcctgccgc ctgtcctttc      660

tcatcccatc tttgacaatc acgatcgtca ccggattgag gagaaacgta aaaggacata      720

tgagaccttc aagagcatca tgaagaagag tcctttcagc ggacccaccg acccccggcc      780

tccacctcga cgcattgctg tgccttcccg cagctcagct tctgtcccca agccagcacc      840

ccagccctat ccctttacgt catccctgag caccatcaac tatgatgagt ttcccaccat      900

ggtgtttcct tctgggcaga tcagccaggc ctcggccttg gccccggccc ctccccaagt      960

cctgccccag gctccagccc ctgcccctgc tccagccatg gtatcagctc tggcccaggc     1020

cccagcccct gtcccagtcc tagccccagg ccctcctcag gctgtggccc cacctgcccc     1080

caagcccacc caggctgggg aaggaacgct gtcagaggcc ctgctgcagc tgcagtttga     1140

tgatgaagac ctgggggcct tgcttggcaa cagcacagac ccagctgtgt tcacagacct     1200

ggcatccgtc gacaactccg agtttcagca gctgctgaac cagggcatac ctgtggcccc     1260

ccacacaact gagcccatgc tgatggagta ccctgaggct ataactcgcc tagtgacagg     1320

ggcccagagg ccccccgacc cagctcctgc tccactgggg gccccggggc tccccaatgg     1380

cctcctttca ggagatgaag acttctcctc cattgcggac atggacttct cagccctgct     1440

gagtcagatc agctcctaag ggggtgacgc ctgccctccc cagagcactg ggttgcaggg     1500

gattgaagcc ctccaaaagc acttacggat tctggtgggg tgtgttccaa ctgcccccaa     1560

ctttgtggat gtcttccttg gaggggggag ccatatttta ttcttttatt gtcagtatct     1620

gtatctctct ctctttttgg aggtgcttaa gcagaagcat taacttctct ggaaaggggg     1680

gagctgggga aactcaaact tttcccctgt cctgatggtc agctcccttc tctgtaggga     1740

actctggggt cccccatccc catcctccag cttctggtac tctcctagag acagaagcag     1800

gctggaggta aggcctttga gcccacaaag ccttatcaag tgtcttccat catggattca     1860

ttacagctta atcaaaataa cgccccagat accagcccct gtatggcact ggcattgtcc     1920

ctgtgcctaa caccagcgtt tgaggggctg gccttcctgc cctacagagg tctctgccgg     1980

ctctttcctt gctcaaccat ggctgaagga aaccagtgca acagcactgg ctctctccag     2040

gatccagaag gggtttggtc tgggacttcc ttgctctccc tcttctcaag tgccttaata     2100

gtagggtaag ttgttaagag tgggggagag caggctggca gctctccagt caggaggcat     2160

agtttttact gaacaatcaa agcacttgga ctcttgctct ttctactctg aactaataaa     2220

tctgttgcca agctgg                                                     2236


<210>  24
<211>  2555
<212>  PRT
<213>  Homo sapiens

<400>  24

Met Pro Pro Leu Leu Ala Pro Leu Leu Cys Leu Ala Leu Leu Pro Ala 
1               5                   10                  15      


Leu Ala Ala Arg Gly Pro Arg Cys Ser Gln Pro Gly Glu Thr Cys Leu 
            20                  25                  30          


Asn Gly Gly Lys Cys Glu Ala Ala Asn Gly Thr Glu Ala Cys Val Cys 
        35                  40                  45              


Gly Gly Ala Phe Val Gly Pro Arg Cys Gln Asp Pro Asn Pro Cys Leu 
    50                  55                  60                  


Ser Thr Pro Cys Lys Asn Ala Gly Thr Cys His Val Val Asp Arg Arg 
65                  70                  75                  80  


Gly Val Ala Asp Tyr Ala Cys Ser Cys Ala Leu Gly Phe Ser Gly Pro 
                85                  90                  95      


Leu Cys Leu Thr Pro Leu Asp Asn Ala Cys Leu Thr Asn Pro Cys Arg 
            100                 105                 110         


Asn Gly Gly Thr Cys Asp Leu Leu Thr Leu Thr Glu Tyr Lys Cys Arg 
        115                 120                 125             


Cys Pro Pro Gly Trp Ser Gly Lys Ser Cys Gln Gln Ala Asp Pro Cys 
    130                 135                 140                 


Ala Ser Asn Pro Cys Ala Asn Gly Gly Gln Cys Leu Pro Phe Glu Ala 
145                 150                 155                 160 


Ser Tyr Ile Cys His Cys Pro Pro Ser Phe His Gly Pro Thr Cys Arg 
                165                 170                 175     


Gln Asp Val Asn Glu Cys Gly Gln Lys Pro Gly Leu Cys Arg His Gly 
            180                 185                 190         


Gly Thr Cys His Asn Glu Val Gly Ser Tyr Arg Cys Val Cys Arg Ala 
        195                 200                 205             


Thr His Thr Gly Pro Asn Cys Glu Arg Pro Tyr Val Pro Cys Ser Pro 
    210                 215                 220                 


Ser Pro Cys Gln Asn Gly Gly Thr Cys Arg Pro Thr Gly Asp Val Thr 
225                 230                 235                 240 


His Glu Cys Ala Cys Leu Pro Gly Phe Thr Gly Gln Asn Cys Glu Glu 
                245                 250                 255     


Asn Ile Asp Asp Cys Pro Gly Asn Asn Cys Lys Asn Gly Gly Ala Cys 
            260                 265                 270         


Val Asp Gly Val Asn Thr Tyr Asn Cys Arg Cys Pro Pro Glu Trp Thr 
        275                 280                 285             


Gly Gln Tyr Cys Thr Glu Asp Val Asp Glu Cys Gln Leu Met Pro Asn 
    290                 295                 300                 


Ala Cys Gln Asn Gly Gly Thr Cys His Asn Thr His Gly Gly Tyr Asn 
305                 310                 315                 320 


Cys Val Cys Val Asn Gly Trp Thr Gly Glu Asp Cys Ser Glu Asn Ile 
                325                 330                 335     


Asp Asp Cys Ala Ser Ala Ala Cys Phe His Gly Ala Thr Cys His Asp 
            340                 345                 350         


Arg Val Ala Ser Phe Tyr Cys Glu Cys Pro His Gly Arg Thr Gly Leu 
        355                 360                 365             


Leu Cys His Leu Asn Asp Ala Cys Ile Ser Asn Pro Cys Asn Glu Gly 
    370                 375                 380                 


Ser Asn Cys Asp Thr Asn Pro Val Asn Gly Lys Ala Ile Cys Thr Cys 
385                 390                 395                 400 


Pro Ser Gly Tyr Thr Gly Pro Ala Cys Ser Gln Asp Val Asp Glu Cys 
                405                 410                 415     


Ser Leu Gly Ala Asn Pro Cys Glu His Ala Gly Lys Cys Ile Asn Thr 
            420                 425                 430         


Leu Gly Ser Phe Glu Cys Gln Cys Leu Gln Gly Tyr Thr Gly Pro Arg 
        435                 440                 445             


Cys Glu Ile Asp Val Asn Glu Cys Val Ser Asn Pro Cys Gln Asn Asp 
    450                 455                 460                 


Ala Thr Cys Leu Asp Gln Ile Gly Glu Phe Gln Cys Ile Cys Met Pro 
465                 470                 475                 480 


Gly Tyr Glu Gly Val His Cys Glu Val Asn Thr Asp Glu Cys Ala Ser 
                485                 490                 495     


Ser Pro Cys Leu His Asn Gly Arg Cys Leu Asp Lys Ile Asn Glu Phe 
            500                 505                 510         


Gln Cys Glu Cys Pro Thr Gly Phe Thr Gly His Leu Cys Gln Tyr Asp 
        515                 520                 525             


Val Asp Glu Cys Ala Ser Thr Pro Cys Lys Asn Gly Ala Lys Cys Leu 
    530                 535                 540                 


Asp Gly Pro Asn Thr Tyr Thr Cys Val Cys Thr Glu Gly Tyr Thr Gly 
545                 550                 555                 560 


Thr His Cys Glu Val Asp Ile Asp Glu Cys Asp Pro Asp Pro Cys His 
                565                 570                 575     


Tyr Gly Ser Cys Lys Asp Gly Val Ala Thr Phe Thr Cys Leu Cys Arg 
            580                 585                 590         


Pro Gly Tyr Thr Gly His His Cys Glu Thr Asn Ile Asn Glu Cys Ser 
        595                 600                 605             


Ser Gln Pro Cys Arg His Gly Gly Thr Cys Gln Asp Arg Asp Asn Ala 
    610                 615                 620                 


Tyr Leu Cys Phe Cys Leu Lys Gly Thr Thr Gly Pro Asn Cys Glu Ile 
625                 630                 635                 640 


Asn Leu Asp Asp Cys Ala Ser Ser Pro Cys Asp Ser Gly Thr Cys Leu 
                645                 650                 655     


Asp Lys Ile Asp Gly Tyr Glu Cys Ala Cys Glu Pro Gly Tyr Thr Gly 
            660                 665                 670         


Ser Met Cys Asn Ile Asn Ile Asp Glu Cys Ala Gly Asn Pro Cys His 
        675                 680                 685             


Asn Gly Gly Thr Cys Glu Asp Gly Ile Asn Gly Phe Thr Cys Arg Cys 
    690                 695                 700                 


Pro Glu Gly Tyr His Asp Pro Thr Cys Leu Ser Glu Val Asn Glu Cys 
705                 710                 715                 720 


Asn Ser Asn Pro Cys Val His Gly Ala Cys Arg Asp Ser Leu Asn Gly 
                725                 730                 735     


Tyr Lys Cys Asp Cys Asp Pro Gly Trp Ser Gly Thr Asn Cys Asp Ile 
            740                 745                 750         


Asn Asn Asn Glu Cys Glu Ser Asn Pro Cys Val Asn Gly Gly Thr Cys 
        755                 760                 765             


Lys Asp Met Thr Ser Gly Tyr Val Cys Thr Cys Arg Glu Gly Phe Ser 
    770                 775                 780                 


Gly Pro Asn Cys Gln Thr Asn Ile Asn Glu Cys Ala Ser Asn Pro Cys 
785                 790                 795                 800 


Leu Asn Gln Gly Thr Cys Ile Asp Asp Val Ala Gly Tyr Lys Cys Asn 
                805                 810                 815     


Cys Leu Leu Pro Tyr Thr Gly Ala Thr Cys Glu Val Val Leu Ala Pro 
            820                 825                 830         


Cys Ala Pro Ser Pro Cys Arg Asn Gly Gly Glu Cys Arg Gln Ser Glu 
        835                 840                 845             


Asp Tyr Glu Ser Phe Ser Cys Val Cys Pro Thr Gly Trp Gln Gly Gln 
    850                 855                 860                 


Thr Cys Glu Val Asp Ile Asn Glu Cys Val Leu Ser Pro Cys Arg His 
865                 870                 875                 880 


Gly Ala Ser Cys Gln Asn Thr His Gly Gly Tyr Arg Cys His Cys Gln 
                885                 890                 895     


Ala Gly Tyr Ser Gly Arg Asn Cys Glu Thr Asp Ile Asp Asp Cys Arg 
            900                 905                 910         


Pro Asn Pro Cys His Asn Gly Gly Ser Cys Thr Asp Gly Ile Asn Thr 
        915                 920                 925             


Ala Phe Cys Asp Cys Leu Pro Gly Phe Arg Gly Thr Phe Cys Glu Glu 
    930                 935                 940                 


Asp Ile Asn Glu Cys Ala Ser Asp Pro Cys Arg Asn Gly Ala Asn Cys 
945                 950                 955                 960 


Thr Asp Cys Val Asp Ser Tyr Thr Cys Thr Cys Pro Ala Gly Phe Ser 
                965                 970                 975     


Gly Ile His Cys Glu Asn Asn Thr Pro Asp Cys Thr Glu Ser Ser Cys 
            980                 985                 990         


Phe Asn Gly Gly Thr Cys Val Asp  Gly Ile Asn Ser Phe  Thr Cys Leu 
        995                 1000                 1005             


Cys Pro  Pro Gly Phe Thr Gly  Ser Tyr Cys Gln His  Asp Val Asn 
    1010                 1015                 1020             


Glu Cys  Asp Ser Gln Pro Cys  Leu His Gly Gly Thr  Cys Gln Asp 
    1025                 1030                 1035             


Gly Cys  Gly Ser Tyr Arg Cys  Thr Cys Pro Gln Gly  Tyr Thr Gly 
    1040                 1045                 1050             


Pro Asn  Cys Gln Asn Leu Val  His Trp Cys Asp Ser  Ser Pro Cys 
    1055                 1060                 1065             


Lys Asn  Gly Gly Lys Cys Trp  Gln Thr His Thr Gln  Tyr Arg Cys 
    1070                 1075                 1080             


Glu Cys  Pro Ser Gly Trp Thr  Gly Leu Tyr Cys Asp  Val Pro Ser 
    1085                 1090                 1095             


Val Ser  Cys Glu Val Ala Ala  Gln Arg Gln Gly Val  Asp Val Ala 
    1100                 1105                 1110             


Arg Leu  Cys Gln His Gly Gly  Leu Cys Val Asp Ala  Gly Asn Thr 
    1115                 1120                 1125             


His His  Cys Arg Cys Gln Ala  Gly Tyr Thr Gly Ser  Tyr Cys Glu 
    1130                 1135                 1140             


Asp Leu  Val Asp Glu Cys Ser  Pro Ser Pro Cys Gln  Asn Gly Ala 
    1145                 1150                 1155             


Thr Cys  Thr Asp Tyr Leu Gly  Gly Tyr Ser Cys Lys  Cys Val Ala 
    1160                 1165                 1170             


Gly Tyr  His Gly Val Asn Cys  Ser Glu Glu Ile Asp  Glu Cys Leu 
    1175                 1180                 1185             


Ser His  Pro Cys Gln Asn Gly  Gly Thr Cys Leu Asp  Leu Pro Asn 
    1190                 1195                 1200             


Thr Tyr  Lys Cys Ser Cys Pro  Arg Gly Thr Gln Gly  Val His Cys 
    1205                 1210                 1215             


Glu Ile  Asn Val Asp Asp Cys  Asn Pro Pro Val Asp  Pro Val Ser 
    1220                 1225                 1230             


Arg Ser  Pro Lys Cys Phe Asn  Asn Gly Thr Cys Val  Asp Gln Val 
    1235                 1240                 1245             


Gly Gly  Tyr Ser Cys Thr Cys  Pro Pro Gly Phe Val  Gly Glu Arg 
    1250                 1255                 1260             


Cys Glu  Gly Asp Val Asn Glu  Cys Leu Ser Asn Pro  Cys Asp Ala 
    1265                 1270                 1275             


Arg Gly  Thr Gln Asn Cys Val  Gln Arg Val Asn Asp  Phe His Cys 
    1280                 1285                 1290             


Glu Cys  Arg Ala Gly His Thr  Gly Arg Arg Cys Glu  Ser Val Ile 
    1295                 1300                 1305             


Asn Gly  Cys Lys Gly Lys Pro  Cys Lys Asn Gly Gly  Thr Cys Ala 
    1310                 1315                 1320             


Val Ala  Ser Asn Thr Ala Arg  Gly Phe Ile Cys Lys  Cys Pro Ala 
    1325                 1330                 1335             


Gly Phe  Glu Gly Ala Thr Cys  Glu Asn Asp Ala Arg  Thr Cys Gly 
    1340                 1345                 1350             


Ser Leu  Arg Cys Leu Asn Gly  Gly Thr Cys Ile Ser  Gly Pro Arg 
    1355                 1360                 1365             


Ser Pro  Thr Cys Leu Cys Leu  Gly Pro Phe Thr Gly  Pro Glu Cys 
    1370                 1375                 1380             


Gln Phe  Pro Ala Ser Ser Pro  Cys Leu Gly Gly Asn  Pro Cys Tyr 
    1385                 1390                 1395             


Asn Gln  Gly Thr Cys Glu Pro  Thr Ser Glu Ser Pro  Phe Tyr Arg 
    1400                 1405                 1410             


Cys Leu  Cys Pro Ala Lys Phe  Asn Gly Leu Leu Cys  His Ile Leu 
    1415                 1420                 1425             


Asp Tyr  Ser Phe Gly Gly Gly  Ala Gly Arg Asp Ile  Pro Pro Pro 
    1430                 1435                 1440             


Leu Ile  Glu Glu Ala Cys Glu  Leu Pro Glu Cys Gln  Glu Asp Ala 
    1445                 1450                 1455             


Gly Asn  Lys Val Cys Ser Leu  Gln Cys Asn Asn His  Ala Cys Gly 
    1460                 1465                 1470             


Trp Asp  Gly Gly Asp Cys Ser  Leu Asn Phe Asn Asp  Pro Trp Lys 
    1475                 1480                 1485             


Asn Cys  Thr Gln Ser Leu Gln  Cys Trp Lys Tyr Phe  Ser Asp Gly 
    1490                 1495                 1500             


His Cys  Asp Ser Gln Cys Asn  Ser Ala Gly Cys Leu  Phe Asp Gly 
    1505                 1510                 1515             


Phe Asp  Cys Gln Arg Ala Glu  Gly Gln Cys Asn Pro  Leu Tyr Asp 
    1520                 1525                 1530             


Gln Tyr  Cys Lys Asp His Phe  Ser Asp Gly His Cys  Asp Gln Gly 
    1535                 1540                 1545             


Cys Asn  Ser Ala Glu Cys Glu  Trp Asp Gly Leu Asp  Cys Ala Glu 
    1550                 1555                 1560             


His Val  Pro Glu Arg Leu Ala  Ala Gly Thr Leu Val  Val Val Val 
    1565                 1570                 1575             


Leu Met  Pro Pro Glu Gln Leu  Arg Asn Ser Ser Phe  His Phe Leu 
    1580                 1585                 1590             


Arg Glu  Leu Ser Arg Val Leu  His Thr Asn Val Val  Phe Lys Arg 
    1595                 1600                 1605             


Asp Ala  His Gly Gln Gln Met  Ile Phe Pro Tyr Tyr  Gly Arg Glu 
    1610                 1615                 1620             


Glu Glu  Leu Arg Lys His Pro  Ile Lys Arg Ala Ala  Glu Gly Trp 
    1625                 1630                 1635             


Ala Ala  Pro Asp Ala Leu Leu  Gly Gln Val Lys Ala  Ser Leu Leu 
    1640                 1645                 1650             


Pro Gly  Gly Ser Glu Gly Gly  Arg Arg Arg Arg Glu  Leu Asp Pro 
    1655                 1660                 1665             


Met Asp  Val Arg Gly Ser Ile  Val Tyr Leu Glu Ile  Asp Asn Arg 
    1670                 1675                 1680             


Gln Cys  Val Gln Ala Ser Ser  Gln Cys Phe Gln Ser  Ala Thr Asp 
    1685                 1690                 1695             


Val Ala  Ala Phe Leu Gly Ala  Leu Ala Ser Leu Gly  Ser Leu Asn 
    1700                 1705                 1710             


Ile Pro  Tyr Lys Ile Glu Ala  Val Gln Ser Glu Thr  Val Glu Pro 
    1715                 1720                 1725             


Pro Pro  Pro Ala Gln Leu His  Phe Met Tyr Val Ala  Ala Ala Ala 
    1730                 1735                 1740             


Phe Val  Leu Leu Phe Phe Val  Gly Cys Gly Val Leu  Leu Ser Arg 
    1745                 1750                 1755             


Lys Arg  Arg Arg Gln His Gly  Gln Leu Trp Phe Pro  Glu Gly Phe 
    1760                 1765                 1770             


Lys Val  Ser Glu Ala Ser Lys  Lys Lys Arg Arg Glu  Pro Leu Gly 
    1775                 1780                 1785             


Glu Asp  Ser Val Gly Leu Lys  Pro Leu Lys Asn Ala  Ser Asp Gly 
    1790                 1795                 1800             


Ala Leu  Met Asp Asp Asn Gln  Asn Glu Trp Gly Asp  Glu Asp Leu 
    1805                 1810                 1815             


Glu Thr  Lys Lys Phe Arg Phe  Glu Glu Pro Val Val  Leu Pro Asp 
    1820                 1825                 1830             


Leu Asp  Asp Gln Thr Asp His  Arg Gln Trp Thr Gln  Gln His Leu 
    1835                 1840                 1845             


Asp Ala  Ala Asp Leu Arg Met  Ser Ala Met Ala Pro  Thr Pro Pro 
    1850                 1855                 1860             


Gln Gly  Glu Val Asp Ala Asp  Cys Met Asp Val Asn  Val Arg Gly 
    1865                 1870                 1875             


Pro Asp  Gly Phe Thr Pro Leu  Met Ile Ala Ser Cys  Ser Gly Gly 
    1880                 1885                 1890             


Gly Leu  Glu Thr Gly Asn Ser  Glu Glu Glu Glu Asp  Ala Pro Ala 
    1895                 1900                 1905             


Val Ile  Ser Asp Phe Ile Tyr  Gln Gly Ala Ser Leu  His Asn Gln 
    1910                 1915                 1920             


Thr Asp  Arg Thr Gly Glu Thr  Ala Leu His Leu Ala  Ala Arg Tyr 
    1925                 1930                 1935             


Ser Arg  Ser Asp Ala Ala Lys  Arg Leu Leu Glu Ala  Ser Ala Asp 
    1940                 1945                 1950             


Ala Asn  Ile Gln Asp Asn Met  Gly Arg Thr Pro Leu  His Ala Ala 
    1955                 1960                 1965             


Val Ser  Ala Asp Ala Gln Gly  Val Phe Gln Ile Leu  Ile Arg Asn 
    1970                 1975                 1980             


Arg Ala  Thr Asp Leu Asp Ala  Arg Met His Asp Gly  Thr Thr Pro 
    1985                 1990                 1995             


Leu Ile  Leu Ala Ala Arg Leu  Ala Val Glu Gly Met  Leu Glu Asp 
    2000                 2005                 2010             


Leu Ile  Asn Ser His Ala Asp  Val Asn Ala Val Asp  Asp Leu Gly 
    2015                 2020                 2025             


Lys Ser  Ala Leu His Trp Ala  Ala Ala Val Asn Asn  Val Asp Ala 
    2030                 2035                 2040             


Ala Val  Val Leu Leu Lys Asn  Gly Ala Asn Lys Asp  Met Gln Asn 
    2045                 2050                 2055             


Asn Arg  Glu Glu Thr Pro Leu  Phe Leu Ala Ala Arg  Glu Gly Ser 
    2060                 2065                 2070             


Tyr Glu  Thr Ala Lys Val Leu  Leu Asp His Phe Ala  Asn Arg Asp 
    2075                 2080                 2085             


Ile Thr  Asp His Met Asp Arg  Leu Pro Arg Asp Ile  Ala Gln Glu 
    2090                 2095                 2100             


Arg Met  His His Asp Ile Val  Arg Leu Leu Asp Glu  Tyr Asn Leu 
    2105                 2110                 2115             


Val Arg  Ser Pro Gln Leu His  Gly Ala Pro Leu Gly  Gly Thr Pro 
    2120                 2125                 2130             


Thr Leu  Ser Pro Pro Leu Cys  Ser Pro Asn Gly Tyr  Leu Gly Ser 
    2135                 2140                 2145             


Leu Lys  Pro Gly Val Gln Gly  Lys Lys Val Arg Lys  Pro Ser Ser 
    2150                 2155                 2160             


Lys Gly  Leu Ala Cys Gly Ser  Lys Glu Ala Lys Asp  Leu Lys Ala 
    2165                 2170                 2175             


Arg Arg  Lys Lys Ser Gln Asp  Gly Lys Gly Cys Leu  Leu Asp Ser 
    2180                 2185                 2190             


Ser Gly  Met Leu Ser Pro Val  Asp Ser Leu Glu Ser  Pro His Gly 
    2195                 2200                 2205             


Tyr Leu  Ser Asp Val Ala Ser  Pro Pro Leu Leu Pro  Ser Pro Phe 
    2210                 2215                 2220             


Gln Gln  Ser Pro Ser Val Pro  Leu Asn His Leu Pro  Gly Met Pro 
    2225                 2230                 2235             


Asp Thr  His Leu Gly Ile Gly  His Leu Asn Val Ala  Ala Lys Pro 
    2240                 2245                 2250             


Glu Met  Ala Ala Leu Gly Gly  Gly Gly Arg Leu Ala  Phe Glu Thr 
    2255                 2260                 2265             


Gly Pro  Pro Arg Leu Ser His  Leu Pro Val Ala Ser  Gly Thr Ser 
    2270                 2275                 2280             


Thr Val  Leu Gly Ser Ser Ser  Gly Gly Ala Leu Asn  Phe Thr Val 
    2285                 2290                 2295             


Gly Gly  Ser Thr Ser Leu Asn  Gly Gln Cys Glu Trp  Leu Ser Arg 
    2300                 2305                 2310             


Leu Gln  Ser Gly Met Val Pro  Asn Gln Tyr Asn Pro  Leu Arg Gly 
    2315                 2320                 2325             


Ser Val  Ala Pro Gly Pro Leu  Ser Thr Gln Ala Pro  Ser Leu Gln 
    2330                 2335                 2340             


His Gly  Met Val Gly Pro Leu  His Ser Ser Leu Ala  Ala Ser Ala 
    2345                 2350                 2355             


Leu Ser  Gln Met Met Ser Tyr  Gln Gly Leu Pro Ser  Thr Arg Leu 
    2360                 2365                 2370             


Ala Thr  Gln Pro His Leu Val  Gln Thr Gln Gln Val  Gln Pro Gln 
    2375                 2380                 2385             


Asn Leu  Gln Met Gln Gln Gln  Asn Leu Gln Pro Ala  Asn Ile Gln 
    2390                 2395                 2400             


Gln Gln  Gln Ser Leu Gln Pro  Pro Pro Pro Pro Pro  Gln Pro His 
    2405                 2410                 2415             


Leu Gly  Val Ser Ser Ala Ala  Ser Gly His Leu Gly  Arg Ser Phe 
    2420                 2425                 2430             


Leu Ser  Gly Glu Pro Ser Gln  Ala Asp Val Gln Pro  Leu Gly Pro 
    2435                 2440                 2445             


Ser Ser  Leu Ala Val His Thr  Ile Leu Pro Gln Glu  Ser Pro Ala 
    2450                 2455                 2460             


Leu Pro  Thr Ser Leu Pro Ser  Ser Leu Val Pro Pro  Val Thr Ala 
    2465                 2470                 2475             


Ala Gln  Phe Leu Thr Pro Pro  Ser Gln His Ser Tyr  Ser Ser Pro 
    2480                 2485                 2490             


Val Asp  Asn Thr Pro Ser His  Gln Leu Gln Val Pro  Glu His Pro 
    2495                 2500                 2505             


Phe Leu  Thr Pro Ser Pro Glu  Ser Pro Asp Gln Trp  Ser Ser Ser 
    2510                 2515                 2520             


Ser Pro  His Ser Asn Val Ser  Asp Trp Ser Glu Gly  Val Ser Ser 
    2525                 2530                 2535             


Pro Pro  Thr Ser Met Gln Ser  Gln Ile Ala Arg Ile  Pro Glu Ala 
    2540                 2545                 2550             


Phe Lys  
    2555 


<210>  25
<211>  2471
<212>  PRT
<213>  Homo sapiens

<400>  25

Met Pro Ala Leu Arg Pro Ala Leu Leu Trp Ala Leu Leu Ala Leu Trp 
1               5                   10                  15      


Leu Cys Cys Ala Ala Pro Ala His Ala Leu Gln Cys Arg Asp Gly Tyr 
            20                  25                  30          


Glu Pro Cys Val Asn Glu Gly Met Cys Val Thr Tyr His Asn Gly Thr 
        35                  40                  45              


Gly Tyr Cys Lys Cys Pro Glu Gly Phe Leu Gly Glu Tyr Cys Gln His 
    50                  55                  60                  


Arg Asp Pro Cys Glu Lys Asn Arg Cys Gln Asn Gly Gly Thr Cys Val 
65                  70                  75                  80  


Ala Gln Ala Met Leu Gly Lys Ala Thr Cys Arg Cys Ala Ser Gly Phe 
                85                  90                  95      


Thr Gly Glu Asp Cys Gln Tyr Ser Thr Ser His Pro Cys Phe Val Ser 
            100                 105                 110         


Arg Pro Cys Leu Asn Gly Gly Thr Cys His Met Leu Ser Arg Asp Thr 
        115                 120                 125             


Tyr Glu Cys Thr Cys Gln Val Gly Phe Thr Gly Lys Glu Cys Gln Trp 
    130                 135                 140                 


Thr Asp Ala Cys Leu Ser His Pro Cys Ala Asn Gly Ser Thr Cys Thr 
145                 150                 155                 160 


Thr Val Ala Asn Gln Phe Ser Cys Lys Cys Leu Thr Gly Phe Thr Gly 
                165                 170                 175     


Gln Lys Cys Glu Thr Asp Val Asn Glu Cys Asp Ile Pro Gly His Cys 
            180                 185                 190         


Gln His Gly Gly Thr Cys Leu Asn Leu Pro Gly Ser Tyr Gln Cys Gln 
        195                 200                 205             


Cys Pro Gln Gly Phe Thr Gly Gln Tyr Cys Asp Ser Leu Tyr Val Pro 
    210                 215                 220                 


Cys Ala Pro Ser Pro Cys Val Asn Gly Gly Thr Cys Arg Gln Thr Gly 
225                 230                 235                 240 


Asp Phe Thr Phe Glu Cys Asn Cys Leu Pro Gly Phe Glu Gly Ser Thr 
                245                 250                 255     


Cys Glu Arg Asn Ile Asp Asp Cys Pro Asn His Arg Cys Gln Asn Gly 
            260                 265                 270         


Gly Val Cys Val Asp Gly Val Asn Thr Tyr Asn Cys Arg Cys Pro Pro 
        275                 280                 285             


Gln Trp Thr Gly Gln Phe Cys Thr Glu Asp Val Asp Glu Cys Leu Leu 
    290                 295                 300                 


Gln Pro Asn Ala Cys Gln Asn Gly Gly Thr Cys Ala Asn Arg Asn Gly 
305                 310                 315                 320 


Gly Tyr Gly Cys Val Cys Val Asn Gly Trp Ser Gly Asp Asp Cys Ser 
                325                 330                 335     


Glu Asn Ile Asp Asp Cys Ala Phe Ala Ser Cys Thr Pro Gly Ser Thr 
            340                 345                 350         


Cys Ile Asp Arg Val Ala Ser Phe Ser Cys Met Cys Pro Glu Gly Lys 
        355                 360                 365             


Ala Gly Leu Leu Cys His Leu Asp Asp Ala Cys Ile Ser Asn Pro Cys 
    370                 375                 380                 


His Lys Gly Ala Leu Cys Asp Thr Asn Pro Leu Asn Gly Gln Tyr Ile 
385                 390                 395                 400 


Cys Thr Cys Pro Gln Gly Tyr Lys Gly Ala Asp Cys Thr Glu Asp Val 
                405                 410                 415     


Asp Glu Cys Ala Met Ala Asn Ser Asn Pro Cys Glu His Ala Gly Lys 
            420                 425                 430         


Cys Val Asn Thr Asp Gly Ala Phe His Cys Glu Cys Leu Lys Gly Tyr 
        435                 440                 445             


Ala Gly Pro Arg Cys Glu Met Asp Ile Asn Glu Cys His Ser Asp Pro 
    450                 455                 460                 


Cys Gln Asn Asp Ala Thr Cys Leu Asp Lys Ile Gly Gly Phe Thr Cys 
465                 470                 475                 480 


Leu Cys Met Pro Gly Phe Lys Gly Val His Cys Glu Leu Glu Ile Asn 
                485                 490                 495     


Glu Cys Gln Ser Asn Pro Cys Val Asn Asn Gly Gln Cys Val Asp Lys 
            500                 505                 510         


Val Asn Arg Phe Gln Cys Leu Cys Pro Pro Gly Phe Thr Gly Pro Val 
        515                 520                 525             


Cys Gln Ile Asp Ile Asp Asp Cys Ser Ser Thr Pro Cys Leu Asn Gly 
    530                 535                 540                 


Ala Lys Cys Ile Asp His Pro Asn Gly Tyr Glu Cys Gln Cys Ala Thr 
545                 550                 555                 560 


Gly Phe Thr Gly Val Leu Cys Glu Glu Asn Ile Asp Asn Cys Asp Pro 
                565                 570                 575     


Asp Pro Cys His His Gly Gln Cys Gln Asp Gly Ile Asp Ser Tyr Thr 
            580                 585                 590         


Cys Ile Cys Asn Pro Gly Tyr Met Gly Ala Ile Cys Ser Asp Gln Ile 
        595                 600                 605             


Asp Glu Cys Tyr Ser Ser Pro Cys Leu Asn Asp Gly Arg Cys Ile Asp 
    610                 615                 620                 


Leu Val Asn Gly Tyr Gln Cys Asn Cys Gln Pro Gly Thr Ser Gly Val 
625                 630                 635                 640 


Asn Cys Glu Ile Asn Phe Asp Asp Cys Ala Ser Asn Pro Cys Ile His 
                645                 650                 655     


Gly Ile Cys Met Asp Gly Ile Asn Arg Tyr Ser Cys Val Cys Ser Pro 
            660                 665                 670         


Gly Phe Thr Gly Gln Arg Cys Asn Ile Asp Ile Asp Glu Cys Ala Ser 
        675                 680                 685             


Asn Pro Cys Arg Lys Gly Ala Thr Cys Ile Asn Gly Val Asn Gly Phe 
    690                 695                 700                 


Arg Cys Ile Cys Pro Glu Gly Pro His His Pro Ser Cys Tyr Ser Gln 
705                 710                 715                 720 


Val Asn Glu Cys Leu Ser Asn Pro Cys Ile His Gly Asn Cys Thr Gly 
                725                 730                 735     


Gly Leu Ser Gly Tyr Lys Cys Leu Cys Asp Ala Gly Trp Val Gly Ile 
            740                 745                 750         


Asn Cys Glu Val Asp Lys Asn Glu Cys Leu Ser Asn Pro Cys Gln Asn 
        755                 760                 765             


Gly Gly Thr Cys Asp Asn Leu Val Asn Gly Tyr Arg Cys Thr Cys Lys 
    770                 775                 780                 


Lys Gly Phe Lys Gly Tyr Asn Cys Gln Val Asn Ile Asp Glu Cys Ala 
785                 790                 795                 800 


Ser Asn Pro Cys Leu Asn Gln Gly Thr Cys Phe Asp Asp Ile Ser Gly 
                805                 810                 815     


Tyr Thr Cys His Cys Val Leu Pro Tyr Thr Gly Lys Asn Cys Gln Thr 
            820                 825                 830         


Val Leu Ala Pro Cys Ser Pro Asn Pro Cys Glu Asn Ala Ala Val Cys 
        835                 840                 845             


Lys Glu Ser Pro Asn Phe Glu Ser Tyr Thr Cys Leu Cys Ala Pro Gly 
    850                 855                 860                 


Trp Gln Gly Gln Arg Cys Thr Ile Asp Ile Asp Glu Cys Ile Ser Lys 
865                 870                 875                 880 


Pro Cys Met Asn His Gly Leu Cys His Asn Thr Gln Gly Ser Tyr Met 
                885                 890                 895     


Cys Glu Cys Pro Pro Gly Phe Ser Gly Met Asp Cys Glu Glu Asp Ile 
            900                 905                 910         


Asp Asp Cys Leu Ala Asn Pro Cys Gln Asn Gly Gly Ser Cys Met Asp 
        915                 920                 925             


Gly Val Asn Thr Phe Ser Cys Leu Cys Leu Pro Gly Phe Thr Gly Asp 
    930                 935                 940                 


Lys Cys Gln Thr Asp Met Asn Glu Cys Leu Ser Glu Pro Cys Lys Asn 
945                 950                 955                 960 


Gly Gly Thr Cys Ser Asp Tyr Val Asn Ser Tyr Thr Cys Lys Cys Gln 
                965                 970                 975     


Ala Gly Phe Asp Gly Val His Cys Glu Asn Asn Ile Asn Glu Cys Thr 
            980                 985                 990         


Glu Ser Ser Cys Phe Asn Gly Gly  Thr Cys Val Asp Gly  Ile Asn Ser 
        995                 1000                 1005             


Phe Ser  Cys Leu Cys Pro Val  Gly Phe Thr Gly Ser  Phe Cys Leu 
    1010                 1015                 1020             


His Glu  Ile Asn Glu Cys Ser  Ser His Pro Cys Leu  Asn Glu Gly 
    1025                 1030                 1035             


Thr Cys  Val Asp Gly Leu Gly  Thr Tyr Arg Cys Ser  Cys Pro Leu 
    1040                 1045                 1050             


Gly Tyr  Thr Gly Lys Asn Cys  Gln Thr Leu Val Asn  Leu Cys Ser 
    1055                 1060                 1065             


Arg Ser  Pro Cys Lys Asn Lys  Gly Thr Cys Val Gln  Lys Lys Ala 
    1070                 1075                 1080             


Glu Ser  Gln Cys Leu Cys Pro  Ser Gly Trp Ala Gly  Ala Tyr Cys 
    1085                 1090                 1095             


Asp Val  Pro Asn Val Ser Cys  Asp Ile Ala Ala Ser  Arg Arg Gly 
    1100                 1105                 1110             


Val Leu  Val Glu His Leu Cys  Gln His Ser Gly Val  Cys Ile Asn 
    1115                 1120                 1125             


Ala Gly  Asn Thr His Tyr Cys  Gln Cys Pro Leu Gly  Tyr Thr Gly 
    1130                 1135                 1140             


Ser Tyr  Cys Glu Glu Gln Leu  Asp Glu Cys Ala Ser  Asn Pro Cys 
    1145                 1150                 1155             


Gln His  Gly Ala Thr Cys Ser  Asp Phe Ile Gly Gly  Tyr Arg Cys 
    1160                 1165                 1170             


Glu Cys  Val Pro Gly Tyr Gln  Gly Val Asn Cys Glu  Tyr Glu Val 
    1175                 1180                 1185             


Asp Glu  Cys Gln Asn Gln Pro  Cys Gln Asn Gly Gly  Thr Cys Ile 
    1190                 1195                 1200             


Asp Leu  Val Asn His Phe Lys  Cys Ser Cys Pro Pro  Gly Thr Arg 
    1205                 1210                 1215             


Gly Leu  Leu Cys Glu Glu Asn  Ile Asp Asp Cys Ala  Arg Gly Pro 
    1220                 1225                 1230             


His Cys  Leu Asn Gly Gly Gln  Cys Met Asp Arg Ile  Gly Gly Tyr 
    1235                 1240                 1245             


Ser Cys  Arg Cys Leu Pro Gly  Phe Ala Gly Glu Arg  Cys Glu Gly 
    1250                 1255                 1260             


Asp Ile  Asn Glu Cys Leu Ser  Asn Pro Cys Ser Ser  Glu Gly Ser 
    1265                 1270                 1275             


Leu Asp  Cys Ile Gln Leu Thr  Asn Asp Tyr Leu Cys  Val Cys Arg 
    1280                 1285                 1290             


Ser Ala  Phe Thr Gly Arg His  Cys Glu Thr Phe Val  Asp Val Cys 
    1295                 1300                 1305             


Pro Gln  Met Pro Cys Leu Asn  Gly Gly Thr Cys Ala  Val Ala Ser 
    1310                 1315                 1320             


Asn Met  Pro Asp Gly Phe Ile  Cys Arg Cys Pro Pro  Gly Phe Ser 
    1325                 1330                 1335             


Gly Ala  Arg Cys Gln Ser Ser  Cys Gly Gln Val Lys  Cys Arg Lys 
    1340                 1345                 1350             


Gly Glu  Gln Cys Val His Thr  Ala Ser Gly Pro Arg  Cys Phe Cys 
    1355                 1360                 1365             


Pro Ser  Pro Arg Asp Cys Glu  Ser Gly Cys Ala Ser  Ser Pro Cys 
    1370                 1375                 1380             


Gln His  Gly Gly Ser Cys His  Pro Gln Arg Gln Pro  Pro Tyr Tyr 
    1385                 1390                 1395             


Ser Cys  Gln Cys Ala Pro Pro  Phe Ser Gly Ser Arg  Cys Glu Leu 
    1400                 1405                 1410             


Tyr Thr  Ala Pro Pro Ser Thr  Pro Pro Ala Thr Cys  Leu Ser Gln 
    1415                 1420                 1425             


Tyr Cys  Ala Asp Lys Ala Arg  Asp Gly Val Cys Asp  Glu Ala Cys 
    1430                 1435                 1440             


Asn Ser  His Ala Cys Gln Trp  Asp Gly Gly Asp Cys  Ser Leu Thr 
    1445                 1450                 1455             


Met Glu  Asn Pro Trp Ala Asn  Cys Ser Ser Pro Leu  Pro Cys Trp 
    1460                 1465                 1470             


Asp Tyr  Ile Asn Asn Gln Cys  Asp Glu Leu Cys Asn  Thr Val Glu 
    1475                 1480                 1485             


Cys Leu  Phe Asp Asn Phe Glu  Cys Gln Gly Asn Ser  Lys Thr Cys 
    1490                 1495                 1500             


Lys Tyr  Asp Lys Tyr Cys Ala  Asp His Phe Lys Asp  Asn His Cys 
    1505                 1510                 1515             


Asp Gln  Gly Cys Asn Ser Glu  Glu Cys Gly Trp Asp  Gly Leu Asp 
    1520                 1525                 1530             


Cys Ala  Ala Asp Gln Pro Glu  Asn Leu Ala Glu Gly  Thr Leu Val 
    1535                 1540                 1545             


Ile Val  Val Leu Met Pro Pro  Glu Gln Leu Leu Gln  Asp Ala Arg 
    1550                 1555                 1560             


Ser Phe  Leu Arg Ala Leu Gly  Thr Leu Leu His Thr  Asn Leu Arg 
    1565                 1570                 1575             


Ile Lys  Arg Asp Ser Gln Gly  Glu Leu Met Val Tyr  Pro Tyr Tyr 
    1580                 1585                 1590             


Gly Glu  Lys Ser Ala Ala Met  Lys Lys Gln Arg Met  Thr Arg Arg 
    1595                 1600                 1605             


Ser Leu  Pro Gly Glu Gln Glu  Gln Glu Val Ala Gly  Ser Lys Val 
    1610                 1615                 1620             


Phe Leu  Glu Ile Asp Asn Arg  Gln Cys Val Gln Asp  Ser Asp His 
    1625                 1630                 1635             


Cys Phe  Lys Asn Thr Asp Ala  Ala Ala Ala Leu Leu  Ala Ser His 
    1640                 1645                 1650             


Ala Ile  Gln Gly Thr Leu Ser  Tyr Pro Leu Val Ser  Val Val Ser 
    1655                 1660                 1665             


Glu Ser  Leu Thr Pro Glu Arg  Thr Gln Leu Leu Tyr  Leu Leu Ala 
    1670                 1675                 1680             


Val Ala  Val Val Ile Ile Leu  Phe Ile Ile Leu Leu  Gly Val Ile 
    1685                 1690                 1695             


Met Ala  Lys Arg Lys Arg Lys  His Gly Ser Leu Trp  Leu Pro Glu 
    1700                 1705                 1710             


Gly Phe  Thr Leu Arg Arg Asp  Ala Ser Asn His Lys  Arg Arg Glu 
    1715                 1720                 1725             


Pro Val  Gly Gln Asp Ala Val  Gly Leu Lys Asn Leu  Ser Val Gln 
    1730                 1735                 1740             


Val Ser  Glu Ala Asn Leu Ile  Gly Thr Gly Thr Ser  Glu His Trp 
    1745                 1750                 1755             


Val Asp  Asp Glu Gly Pro Gln  Pro Lys Lys Val Lys  Ala Glu Asp 
    1760                 1765                 1770             


Glu Ala  Leu Leu Ser Glu Glu  Asp Asp Pro Ile Asp  Arg Arg Pro 
    1775                 1780                 1785             


Trp Thr  Gln Gln His Leu Glu  Ala Ala Asp Ile Arg  Arg Thr Pro 
    1790                 1795                 1800             


Ser Leu  Ala Leu Thr Pro Pro  Gln Ala Glu Gln Glu  Val Asp Val 
    1805                 1810                 1815             


Leu Asp  Val Asn Val Arg Gly  Pro Asp Gly Cys Thr  Pro Leu Met 
    1820                 1825                 1830             


Leu Ala  Ser Leu Arg Gly Gly  Ser Ser Asp Leu Ser  Asp Glu Asp 
    1835                 1840                 1845             


Glu Asp  Ala Glu Asp Ser Ser  Ala Asn Ile Ile Thr  Asp Leu Val 
    1850                 1855                 1860             


Tyr Gln  Gly Ala Ser Leu Gln  Ala Gln Thr Asp Arg  Thr Gly Glu 
    1865                 1870                 1875             


Met Ala  Leu His Leu Ala Ala  Arg Tyr Ser Arg Ala  Asp Ala Ala 
    1880                 1885                 1890             


Lys Arg  Leu Leu Asp Ala Gly  Ala Asp Ala Asn Ala  Gln Asp Asn 
    1895                 1900                 1905             


Met Gly  Arg Cys Pro Leu His  Ala Ala Val Ala Ala  Asp Ala Gln 
    1910                 1915                 1920             


Gly Val  Phe Gln Ile Leu Ile  Arg Asn Arg Val Thr  Asp Leu Asp 
    1925                 1930                 1935             


Ala Arg  Met Asn Asp Gly Thr  Thr Pro Leu Ile Leu  Ala Ala Arg 
    1940                 1945                 1950             


Leu Ala  Val Glu Gly Met Val  Ala Glu Leu Ile Asn  Cys Gln Ala 
    1955                 1960                 1965             


Asp Val  Asn Ala Val Asp Asp  His Gly Lys Ser Ala  Leu His Trp 
    1970                 1975                 1980             


Ala Ala  Ala Val Asn Asn Val  Glu Ala Thr Leu Leu  Leu Leu Lys 
    1985                 1990                 1995             


Asn Gly  Ala Asn Arg Asp Met  Gln Asp Asn Lys Glu  Glu Thr Pro 
    2000                 2005                 2010             


Leu Phe  Leu Ala Ala Arg Glu  Gly Ser Tyr Glu Ala  Ala Lys Ile 
    2015                 2020                 2025             


Leu Leu  Asp His Phe Ala Asn  Arg Asp Ile Thr Asp  His Met Asp 
    2030                 2035                 2040             


Arg Leu  Pro Arg Asp Val Ala  Arg Asp Arg Met His  His Asp Ile 
    2045                 2050                 2055             


Val Arg  Leu Leu Asp Glu Tyr  Asn Val Thr Pro Ser  Pro Pro Gly 
    2060                 2065                 2070             


Thr Val  Leu Thr Ser Ala Leu  Ser Pro Val Ile Cys  Gly Pro Asn 
    2075                 2080                 2085             


Arg Ser  Phe Leu Ser Leu Lys  His Thr Pro Met Gly  Lys Lys Ser 
    2090                 2095                 2100             


Arg Arg  Pro Ser Ala Lys Ser  Thr Met Pro Thr Ser  Leu Pro Asn 
    2105                 2110                 2115             


Leu Ala  Lys Glu Ala Lys Asp  Ala Lys Gly Ser Arg  Arg Lys Lys 
    2120                 2125                 2130             


Ser Leu  Ser Glu Lys Val Gln  Leu Ser Glu Ser Ser  Val Thr Leu 
    2135                 2140                 2145             


Ser Pro  Val Asp Ser Leu Glu  Ser Pro His Thr Tyr  Val Ser Asp 
    2150                 2155                 2160             


Thr Thr  Ser Ser Pro Met Ile  Thr Ser Pro Gly Ile  Leu Gln Ala 
    2165                 2170                 2175             


Ser Pro  Asn Pro Met Leu Ala  Thr Ala Ala Pro Pro  Ala Pro Val 
    2180                 2185                 2190             


His Ala  Gln His Ala Leu Ser  Phe Ser Asn Leu His  Glu Met Gln 
    2195                 2200                 2205             


Pro Leu  Ala His Gly Ala Ser  Thr Val Leu Pro Ser  Val Ser Gln 
    2210                 2215                 2220             


Leu Leu  Ser His His His Ile  Val Ser Pro Gly Ser  Gly Ser Ala 
    2225                 2230                 2235             


Gly Ser  Leu Ser Arg Leu His  Pro Val Pro Val Pro  Ala Asp Trp 
    2240                 2245                 2250             


Met Asn  Arg Met Glu Val Asn  Glu Thr Gln Tyr Asn  Glu Met Phe 
    2255                 2260                 2265             


Gly Met  Val Leu Ala Pro Ala  Glu Gly Thr His Pro  Gly Ile Ala 
    2270                 2275                 2280             


Pro Gln  Ser Arg Pro Pro Glu  Gly Lys His Ile Thr  Thr Pro Arg 
    2285                 2290                 2295             


Glu Pro  Leu Pro Pro Ile Val  Thr Phe Gln Leu Ile  Pro Lys Gly 
    2300                 2305                 2310             


Ser Ile  Ala Gln Pro Ala Gly  Ala Pro Gln Pro Gln  Ser Thr Cys 
    2315                 2320                 2325             


Pro Pro  Ala Val Ala Gly Pro  Leu Pro Thr Met Tyr  Gln Ile Pro 
    2330                 2335                 2340             


Glu Met  Ala Arg Leu Pro Ser  Val Ala Phe Pro Thr  Ala Met Met 
    2345                 2350                 2355             


Pro Gln  Gln Asp Gly Gln Val  Ala Gln Thr Ile Leu  Pro Ala Tyr 
    2360                 2365                 2370             


His Pro  Phe Pro Ala Ser Val  Gly Lys Tyr Pro Thr  Pro Pro Ser 
    2375                 2380                 2385             


Gln His  Ser Tyr Ala Ser Ser  Asn Ala Ala Glu Arg  Thr Pro Ser 
    2390                 2395                 2400             


His Ser  Gly His Leu Gln Gly  Glu His Pro Tyr Leu  Thr Pro Ser 
    2405                 2410                 2415             


Pro Glu  Ser Pro Asp Gln Trp  Ser Ser Ser Ser Pro  His Ser Ala 
    2420                 2425                 2430             


Ser Asp  Trp Ser Asp Val Thr  Thr Ser Pro Thr Pro  Gly Gly Ala 
    2435                 2440                 2445             


Gly Gly  Gly Gln Arg Gly Pro  Gly Thr His Met Ser  Glu Pro Pro 
    2450                 2455                 2460             


His Asn  Asn Met Gln Val Tyr  Ala 
    2465                 2470     


<210>  26
<211>  1235
<212>  PRT
<213>  Homo sapiens

<400>  26

Met Pro Ala Leu Arg Pro Ala Leu Leu Trp Ala Leu Leu Ala Leu Trp 
1               5                   10                  15      


Leu Cys Cys Ala Ala Pro Ala His Ala Leu Gln Cys Arg Asp Gly Tyr 
            20                  25                  30          


Glu Pro Cys Val Asn Glu Gly Met Cys Val Thr Tyr His Asn Gly Thr 
        35                  40                  45              


Gly Tyr Cys Lys Cys Pro Glu Gly Phe Leu Gly Glu Tyr Cys Gln His 
    50                  55                  60                  


Arg Asp Pro Cys Glu Lys Asn Arg Cys Gln Asn Gly Gly Thr Cys Val 
65                  70                  75                  80  


Ala Gln Ala Met Leu Gly Lys Ala Thr Cys Arg Cys Ala Ser Gly Phe 
                85                  90                  95      


Thr Gly Glu Asp Cys Gln Tyr Ser Thr Ser His Pro Cys Phe Val Ser 
            100                 105                 110         


Arg Pro Cys Leu Asn Gly Gly Thr Cys His Met Leu Ser Arg Asp Thr 
        115                 120                 125             


Tyr Glu Cys Thr Cys Gln Val Gly Phe Thr Gly Lys Glu Cys Gln Trp 
    130                 135                 140                 


Thr Asp Ala Cys Leu Ser His Pro Cys Ala Asn Gly Ser Thr Cys Thr 
145                 150                 155                 160 


Thr Val Ala Asn Gln Phe Ser Cys Lys Cys Leu Thr Gly Phe Thr Gly 
                165                 170                 175     


Gln Lys Cys Glu Thr Asp Val Asn Glu Cys Asp Ile Pro Gly His Cys 
            180                 185                 190         


Gln His Gly Gly Thr Cys Leu Asn Leu Pro Gly Ser Tyr Gln Cys Gln 
        195                 200                 205             


Cys Pro Gln Gly Phe Thr Gly Gln Tyr Cys Asp Ser Leu Tyr Val Pro 
    210                 215                 220                 


Cys Ala Pro Ser Pro Cys Val Asn Gly Gly Thr Cys Arg Gln Thr Gly 
225                 230                 235                 240 


Asp Phe Thr Phe Glu Cys Asn Cys Leu Pro Gly Phe Glu Gly Ser Thr 
                245                 250                 255     


Cys Glu Arg Asn Ile Asp Asp Cys Pro Asn His Arg Cys Gln Asn Gly 
            260                 265                 270         


Gly Val Cys Val Asp Gly Val Asn Thr Tyr Asn Cys Arg Cys Pro Pro 
        275                 280                 285             


Gln Trp Thr Gly Gln Phe Cys Thr Glu Asp Val Asp Glu Cys Leu Leu 
    290                 295                 300                 


Gln Pro Asn Ala Cys Gln Asn Gly Gly Thr Cys Ala Asn Arg Asn Gly 
305                 310                 315                 320 


Gly Tyr Gly Cys Val Cys Val Asn Gly Trp Ser Gly Asp Asp Cys Ser 
                325                 330                 335     


Glu Asn Ile Asp Asp Cys Ala Phe Ala Ser Cys Thr Pro Gly Ser Thr 
            340                 345                 350         


Cys Ile Asp Arg Val Ala Ser Phe Ser Cys Met Cys Pro Glu Gly Lys 
        355                 360                 365             


Ala Gly Leu Leu Cys His Leu Asp Asp Ala Cys Ile Ser Asn Pro Cys 
    370                 375                 380                 


His Lys Gly Ala Leu Cys Asp Thr Asn Pro Leu Asn Gly Gln Tyr Ile 
385                 390                 395                 400 


Cys Thr Cys Pro Gln Gly Tyr Lys Gly Ala Asp Cys Thr Glu Asp Val 
                405                 410                 415     


Asp Glu Cys Ala Met Ala Asn Ser Asn Pro Cys Glu His Ala Gly Lys 
            420                 425                 430         


Cys Val Asn Thr Asp Gly Ala Phe His Cys Glu Cys Leu Lys Gly Tyr 
        435                 440                 445             


Ala Gly Pro Arg Cys Glu Met Asp Ile Asn Glu Cys His Ser Asp Pro 
    450                 455                 460                 


Cys Gln Asn Asp Ala Thr Cys Leu Asp Lys Ile Gly Gly Phe Thr Cys 
465                 470                 475                 480 


Leu Cys Met Pro Gly Phe Lys Gly Val His Cys Glu Leu Glu Ile Asn 
                485                 490                 495     


Glu Cys Gln Ser Asn Pro Cys Val Asn Asn Gly Gln Cys Val Asp Lys 
            500                 505                 510         


Val Asn Arg Phe Gln Cys Leu Cys Pro Pro Gly Phe Thr Gly Pro Val 
        515                 520                 525             


Cys Gln Ile Asp Ile Asp Asp Cys Ser Ser Thr Pro Cys Leu Asn Gly 
    530                 535                 540                 


Ala Lys Cys Ile Asp His Pro Asn Gly Tyr Glu Cys Gln Cys Ala Thr 
545                 550                 555                 560 


Gly Phe Thr Gly Val Leu Cys Glu Glu Asn Ile Asp Asn Cys Asp Pro 
                565                 570                 575     


Asp Pro Cys His His Gly Gln Cys Gln Asp Gly Ile Asp Ser Tyr Thr 
            580                 585                 590         


Cys Ile Cys Asn Pro Gly Tyr Met Gly Ala Ile Cys Ser Asp Gln Ile 
        595                 600                 605             


Asp Glu Cys Tyr Ser Ser Pro Cys Leu Asn Asp Gly Arg Cys Ile Asp 
    610                 615                 620                 


Leu Val Asn Gly Tyr Gln Cys Asn Cys Gln Pro Gly Thr Ser Gly Val 
625                 630                 635                 640 


Asn Cys Glu Ile Asn Phe Asp Asp Cys Ala Ser Asn Pro Cys Ile His 
                645                 650                 655     


Gly Ile Cys Met Asp Gly Ile Asn Arg Tyr Ser Cys Val Cys Ser Pro 
            660                 665                 670         


Gly Phe Thr Gly Gln Arg Cys Asn Ile Asp Ile Asp Glu Cys Ala Ser 
        675                 680                 685             


Asn Pro Cys Arg Lys Gly Ala Thr Cys Ile Asn Gly Val Asn Gly Phe 
    690                 695                 700                 


Arg Cys Ile Cys Pro Glu Gly Pro His His Pro Ser Cys Tyr Ser Gln 
705                 710                 715                 720 


Val Asn Glu Cys Leu Ser Asn Pro Cys Ile His Gly Asn Cys Thr Gly 
                725                 730                 735     


Gly Leu Ser Gly Tyr Lys Cys Leu Cys Asp Ala Gly Trp Val Gly Ile 
            740                 745                 750         


Asn Cys Glu Val Asp Lys Asn Glu Cys Leu Ser Asn Pro Cys Gln Asn 
        755                 760                 765             


Gly Gly Thr Cys Asp Asn Leu Val Asn Gly Tyr Arg Cys Thr Cys Lys 
    770                 775                 780                 


Lys Gly Phe Lys Gly Tyr Asn Cys Gln Val Asn Ile Asp Glu Cys Ala 
785                 790                 795                 800 


Ser Asn Pro Cys Leu Asn Gln Gly Thr Cys Phe Asp Asp Ile Ser Gly 
                805                 810                 815     


Tyr Thr Cys His Cys Val Leu Pro Tyr Thr Gly Lys Asn Cys Gln Thr 
            820                 825                 830         


Val Leu Ala Pro Cys Ser Pro Asn Pro Cys Glu Asn Ala Ala Val Cys 
        835                 840                 845             


Lys Glu Ser Pro Asn Phe Glu Ser Tyr Thr Cys Leu Cys Ala Pro Gly 
    850                 855                 860                 


Trp Gln Gly Gln Arg Cys Thr Ile Asp Ile Asp Glu Cys Ile Ser Lys 
865                 870                 875                 880 


Pro Cys Met Asn His Gly Leu Cys His Asn Thr Gln Gly Ser Tyr Met 
                885                 890                 895     


Cys Glu Cys Pro Pro Gly Phe Ser Gly Met Asp Cys Glu Glu Asp Ile 
            900                 905                 910         


Asp Asp Cys Leu Ala Asn Pro Cys Gln Asn Gly Gly Ser Cys Met Asp 
        915                 920                 925             


Gly Val Asn Thr Phe Ser Cys Leu Cys Leu Pro Gly Phe Thr Gly Asp 
    930                 935                 940                 


Lys Cys Gln Thr Asp Met Asn Glu Cys Leu Ser Glu Pro Cys Lys Asn 
945                 950                 955                 960 


Gly Gly Thr Cys Ser Asp Tyr Val Asn Ser Tyr Thr Cys Lys Cys Gln 
                965                 970                 975     


Ala Gly Phe Asp Gly Val His Cys Glu Asn Asn Ile Asn Glu Cys Thr 
            980                 985                 990         


Glu Ser Ser Cys Phe Asn Gly Gly  Thr Cys Val Asp Gly  Ile Asn Ser 
        995                 1000                 1005             


Phe Ser  Cys Leu Cys Pro Val  Gly Phe Thr Gly Ser  Phe Cys Leu 
    1010                 1015                 1020             


His Glu  Ile Asn Glu Cys Ser  Ser His Pro Cys Leu  Asn Glu Gly 
    1025                 1030                 1035             


Thr Cys  Val Asp Gly Leu Gly  Thr Tyr Arg Cys Ser  Cys Pro Leu 
    1040                 1045                 1050             


Gly Tyr  Thr Gly Lys Asn Cys  Gln Thr Leu Val Asn  Leu Cys Ser 
    1055                 1060                 1065             


Arg Ser  Pro Cys Lys Asn Lys  Gly Thr Cys Val Gln  Lys Lys Ala 
    1070                 1075                 1080             


Glu Ser  Gln Cys Leu Cys Pro  Ser Gly Trp Ala Gly  Ala Tyr Cys 
    1085                 1090                 1095             


Asp Val  Pro Asn Val Ser Cys  Asp Ile Ala Ala Ser  Arg Arg Gly 
    1100                 1105                 1110             


Val Leu  Val Glu His Leu Cys  Gln His Ser Gly Val  Cys Ile Asn 
    1115                 1120                 1125             


Ala Gly  Asn Thr His Tyr Cys  Gln Cys Pro Leu Gly  Tyr Thr Gly 
    1130                 1135                 1140             


Ser Tyr  Cys Glu Glu Gln Leu  Asp Glu Cys Ala Ser  Asn Pro Cys 
    1145                 1150                 1155             


Gln His  Gly Ala Thr Cys Ser  Asp Phe Ile Gly Gly  Tyr Arg Cys 
    1160                 1165                 1170             


Glu Cys  Val Pro Gly Tyr Gln  Gly Val Asn Cys Glu  Tyr Glu Val 
    1175                 1180                 1185             


Asp Glu  Cys Gln Asn Gln Pro  Cys Gln Asn Gly Gly  Thr Cys Ile 
    1190                 1195                 1200             


Asp Leu  Val Asn His Phe Lys  Cys Ser Cys Pro Pro  Gly Thr Arg 
    1205                 1210                 1215             


Gly Met  Lys Ser Ser Leu Ser  Ile Phe His Pro Gly  His Cys Leu 
    1220                 1225                 1230             


Lys Leu  
    1235 


<210>  27
<211>  2321
<212>  PRT
<213>  Homo sapiens

<400>  27

Met Gly Pro Gly Ala Arg Gly Arg Arg Arg Arg Arg Arg Pro Met Ser 
1               5                   10                  15      


Pro Pro Pro Pro Pro Pro Pro Val Arg Ala Leu Pro Leu Leu Leu Leu 
            20                  25                  30          


Leu Ala Gly Pro Gly Ala Ala Ala Pro Pro Cys Leu Asp Gly Ser Pro 
        35                  40                  45              


Cys Ala Asn Gly Gly Arg Cys Thr Gln Leu Pro Ser Arg Glu Ala Ala 
    50                  55                  60                  


Cys Leu Cys Pro Pro Gly Trp Val Gly Glu Arg Cys Gln Leu Glu Asp 
65                  70                  75                  80  


Pro Cys His Ser Gly Pro Cys Ala Gly Arg Gly Val Cys Gln Ser Ser 
                85                  90                  95      


Val Val Ala Gly Thr Ala Arg Phe Ser Cys Arg Cys Pro Arg Gly Phe 
            100                 105                 110         


Arg Gly Pro Asp Cys Ser Leu Pro Asp Pro Cys Leu Ser Ser Pro Cys 
        115                 120                 125             


Ala His Gly Ala Arg Cys Ser Val Gly Pro Asp Gly Arg Phe Leu Cys 
    130                 135                 140                 


Ser Cys Pro Pro Gly Tyr Gln Gly Arg Ser Cys Arg Ser Asp Val Asp 
145                 150                 155                 160 


Glu Cys Arg Val Gly Glu Pro Cys Arg His Gly Gly Thr Cys Leu Asn 
                165                 170                 175     


Thr Pro Gly Ser Phe Arg Cys Gln Cys Pro Ala Gly Tyr Thr Gly Pro 
            180                 185                 190         


Leu Cys Glu Asn Pro Ala Val Pro Cys Ala Pro Ser Pro Cys Arg Asn 
        195                 200                 205             


Gly Gly Thr Cys Arg Gln Ser Gly Asp Leu Thr Tyr Asp Cys Ala Cys 
    210                 215                 220                 


Leu Pro Gly Phe Glu Gly Gln Asn Cys Glu Val Asn Val Asp Asp Cys 
225                 230                 235                 240 


Pro Gly His Arg Cys Leu Asn Gly Gly Thr Cys Val Asp Gly Val Asn 
                245                 250                 255     


Thr Tyr Asn Cys Gln Cys Pro Pro Glu Trp Thr Gly Gln Phe Cys Thr 
            260                 265                 270         


Glu Asp Val Asp Glu Cys Gln Leu Gln Pro Asn Ala Cys His Asn Gly 
        275                 280                 285             


Gly Thr Cys Phe Asn Thr Leu Gly Gly His Ser Cys Val Cys Val Asn 
    290                 295                 300                 


Gly Trp Thr Gly Glu Ser Cys Ser Gln Asn Ile Asp Asp Cys Ala Thr 
305                 310                 315                 320 


Ala Val Cys Phe His Gly Ala Thr Cys His Asp Arg Val Ala Ser Phe 
                325                 330                 335     


Tyr Cys Ala Cys Pro Met Gly Lys Thr Gly Leu Leu Cys His Leu Asp 
            340                 345                 350         


Asp Ala Cys Val Ser Asn Pro Cys His Glu Asp Ala Ile Cys Asp Thr 
        355                 360                 365             


Asn Pro Val Asn Gly Arg Ala Ile Cys Thr Cys Pro Pro Gly Phe Thr 
    370                 375                 380                 


Gly Gly Ala Cys Asp Gln Asp Val Asp Glu Cys Ser Ile Gly Ala Asn 
385                 390                 395                 400 


Pro Cys Glu His Leu Gly Arg Cys Val Asn Thr Gln Gly Ser Phe Leu 
                405                 410                 415     


Cys Gln Cys Gly Arg Gly Tyr Thr Gly Pro Arg Cys Glu Thr Asp Val 
            420                 425                 430         


Asn Glu Cys Leu Ser Gly Pro Cys Arg Asn Gln Ala Thr Cys Leu Asp 
        435                 440                 445             


Arg Ile Gly Gln Phe Thr Cys Ile Cys Met Ala Gly Phe Thr Gly Thr 
    450                 455                 460                 


Tyr Cys Glu Val Asp Ile Asp Glu Cys Gln Ser Ser Pro Cys Val Asn 
465                 470                 475                 480 


Gly Gly Val Cys Lys Asp Arg Val Asn Gly Phe Ser Cys Thr Cys Pro 
                485                 490                 495     


Ser Gly Phe Ser Gly Ser Thr Cys Gln Leu Asp Val Asp Glu Cys Ala 
            500                 505                 510         


Ser Thr Pro Cys Arg Asn Gly Ala Lys Cys Val Asp Gln Pro Asp Gly 
        515                 520                 525             


Tyr Glu Cys Arg Cys Ala Glu Gly Phe Glu Gly Thr Leu Cys Asp Arg 
    530                 535                 540                 


Asn Val Asp Asp Cys Ser Pro Asp Pro Cys His His Gly Arg Cys Val 
545                 550                 555                 560 


Asp Gly Ile Ala Ser Phe Ser Cys Ala Cys Ala Pro Gly Tyr Thr Gly 
                565                 570                 575     


Thr Arg Cys Glu Ser Gln Val Asp Glu Cys Arg Ser Gln Pro Cys Arg 
            580                 585                 590         


His Gly Gly Lys Cys Leu Asp Leu Val Asp Lys Tyr Leu Cys Arg Cys 
        595                 600                 605             


Pro Ser Gly Thr Thr Gly Val Asn Cys Glu Val Asn Ile Asp Asp Cys 
    610                 615                 620                 


Ala Ser Asn Pro Cys Thr Phe Gly Val Cys Arg Asp Gly Ile Asn Arg 
625                 630                 635                 640 


Tyr Asp Cys Val Cys Gln Pro Gly Phe Thr Gly Pro Leu Cys Asn Val 
                645                 650                 655     


Glu Ile Asn Glu Cys Ala Ser Ser Pro Cys Gly Glu Gly Gly Ser Cys 
            660                 665                 670         


Val Asp Gly Glu Asn Gly Phe Arg Cys Leu Cys Pro Pro Gly Ser Leu 
        675                 680                 685             


Pro Pro Leu Cys Leu Pro Pro Ser His Pro Cys Ala His Glu Pro Cys 
    690                 695                 700                 


Ser His Gly Ile Cys Tyr Asp Ala Pro Gly Gly Phe Arg Cys Val Cys 
705                 710                 715                 720 


Glu Pro Gly Trp Ser Gly Pro Arg Cys Ser Gln Ser Leu Ala Arg Asp 
                725                 730                 735     


Ala Cys Glu Ser Gln Pro Cys Arg Ala Gly Gly Thr Cys Ser Ser Asp 
            740                 745                 750         


Gly Met Gly Phe His Cys Thr Cys Pro Pro Gly Val Gln Gly Arg Gln 
        755                 760                 765             


Cys Glu Leu Leu Ser Pro Cys Thr Pro Asn Pro Cys Glu His Gly Gly 
    770                 775                 780                 


Arg Cys Glu Ser Ala Pro Gly Gln Leu Pro Val Cys Ser Cys Pro Gln 
785                 790                 795                 800 


Gly Trp Gln Gly Pro Arg Cys Gln Gln Asp Val Asp Glu Cys Ala Gly 
                805                 810                 815     


Pro Ala Pro Cys Gly Pro His Gly Ile Cys Thr Asn Leu Ala Gly Ser 
            820                 825                 830         


Phe Ser Cys Thr Cys His Gly Gly Tyr Thr Gly Pro Ser Cys Asp Gln 
        835                 840                 845             


Asp Ile Asn Asp Cys Asp Pro Asn Pro Cys Leu Asn Gly Gly Ser Cys 
    850                 855                 860                 


Gln Asp Gly Val Gly Ser Phe Ser Cys Ser Cys Leu Pro Gly Phe Ala 
865                 870                 875                 880 


Gly Pro Arg Cys Ala Arg Asp Val Asp Glu Cys Leu Ser Asn Pro Cys 
                885                 890                 895     


Gly Pro Gly Thr Cys Thr Asp His Val Ala Ser Phe Thr Cys Thr Cys 
            900                 905                 910         


Pro Pro Gly Tyr Gly Gly Phe His Cys Glu Gln Asp Leu Pro Asp Cys 
        915                 920                 925             


Ser Pro Ser Ser Cys Phe Asn Gly Gly Thr Cys Val Asp Gly Val Asn 
    930                 935                 940                 


Ser Phe Ser Cys Leu Cys Arg Pro Gly Tyr Thr Gly Ala His Cys Gln 
945                 950                 955                 960 


His Glu Ala Asp Pro Cys Leu Ser Arg Pro Cys Leu His Gly Gly Val 
                965                 970                 975     


Cys Ser Ala Ala His Pro Gly Phe Arg Cys Thr Cys Leu Glu Ser Phe 
            980                 985                 990         


Thr Gly Pro Gln Cys Gln Thr Leu  Val Asp Trp Cys Ser  Arg Gln Pro 
        995                 1000                 1005             


Cys Gln  Asn Gly Gly Arg Cys  Val Gln Thr Gly Ala  Tyr Cys Leu 
    1010                 1015                 1020             


Cys Pro  Pro Gly Trp Ser Gly  Arg Leu Cys Asp Ile  Arg Ser Leu 
    1025                 1030                 1035             


Pro Cys  Arg Glu Ala Ala Ala  Gln Ile Gly Val Arg  Leu Glu Gln 
    1040                 1045                 1050             


Leu Cys  Gln Ala Gly Gly Gln  Cys Val Asp Glu Asp  Ser Ser His 
    1055                 1060                 1065             


Tyr Cys  Val Cys Pro Glu Gly  Arg Thr Gly Ser His  Cys Glu Gln 
    1070                 1075                 1080             


Glu Val  Asp Pro Cys Leu Ala  Gln Pro Cys Gln His  Gly Gly Thr 
    1085                 1090                 1095             


Cys Arg  Gly Tyr Met Gly Gly  Tyr Met Cys Glu Cys  Leu Pro Gly 
    1100                 1105                 1110             


Tyr Asn  Gly Asp Asn Cys Glu  Asp Asp Val Asp Glu  Cys Ala Ser 
    1115                 1120                 1125             


Gln Pro  Cys Gln His Gly Gly  Ser Cys Ile Asp Leu  Val Ala Arg 
    1130                 1135                 1140             


Tyr Leu  Cys Ser Cys Pro Pro  Gly Thr Leu Gly Val  Leu Cys Glu 
    1145                 1150                 1155             


Ile Asn  Glu Asp Asp Cys Gly  Pro Gly Pro Pro Leu  Asp Ser Gly 
    1160                 1165                 1170             


Pro Arg  Cys Leu His Asn Gly  Thr Cys Val Asp Leu  Val Gly Gly 
    1175                 1180                 1185             


Phe Arg  Cys Thr Cys Pro Pro  Gly Tyr Thr Gly Leu  Arg Cys Glu 
    1190                 1195                 1200             


Ala Asp  Ile Asn Glu Cys Arg  Ser Gly Ala Cys His  Ala Ala His 
    1205                 1210                 1215             


Thr Arg  Asp Cys Leu Gln Asp  Pro Gly Gly Gly Phe  Arg Cys Leu 
    1220                 1225                 1230             


Cys His  Ala Gly Phe Ser Gly  Pro Arg Cys Gln Thr  Val Leu Ser 
    1235                 1240                 1245             


Pro Cys  Glu Ser Gln Pro Cys  Gln His Gly Gly Gln  Cys Arg Pro 
    1250                 1255                 1260             


Ser Pro  Gly Pro Gly Gly Gly  Leu Thr Phe Thr Cys  His Cys Ala 
    1265                 1270                 1275             


Gln Pro  Phe Trp Gly Pro Arg  Cys Glu Arg Val Ala  Arg Ser Cys 
    1280                 1285                 1290             


Arg Glu  Leu Gln Cys Pro Val  Gly Val Pro Cys Gln  Gln Thr Pro 
    1295                 1300                 1305             


Arg Gly  Pro Arg Cys Ala Cys  Pro Pro Gly Leu Ser  Gly Pro Ser 
    1310                 1315                 1320             


Cys Arg  Ser Phe Pro Gly Ser  Pro Pro Gly Ala Ser  Asn Ala Ser 
    1325                 1330                 1335             


Cys Ala  Ala Ala Pro Cys Leu  His Gly Gly Ser Cys  Arg Pro Ala 
    1340                 1345                 1350             


Pro Leu  Ala Pro Phe Phe Arg  Cys Ala Cys Ala Gln  Gly Trp Thr 
    1355                 1360                 1365             


Gly Pro  Arg Cys Glu Ala Pro  Ala Ala Ala Pro Glu  Val Ser Glu 
    1370                 1375                 1380             


Glu Pro  Arg Cys Pro Arg Ala  Ala Cys Gln Ala Lys  Arg Gly Asp 
    1385                 1390                 1395             


Gln Arg  Cys Asp Arg Glu Cys  Asn Ser Pro Gly Cys  Gly Trp Asp 
    1400                 1405                 1410             


Gly Gly  Asp Cys Ser Leu Ser  Val Gly Asp Pro Trp  Arg Gln Cys 
    1415                 1420                 1425             


Glu Ala  Leu Gln Cys Trp Arg  Leu Phe Asn Asn Ser  Arg Cys Asp 
    1430                 1435                 1440             


Pro Ala  Cys Ser Ser Pro Ala  Cys Leu Tyr Asp Asn  Phe Asp Cys 
    1445                 1450                 1455             


His Ala  Gly Gly Arg Glu Arg  Thr Cys Asn Pro Val  Tyr Glu Lys 
    1460                 1465                 1470             


Tyr Cys  Ala Asp His Phe Ala  Asp Gly Arg Cys Asp  Gln Gly Cys 
    1475                 1480                 1485             


Asn Thr  Glu Glu Cys Gly Trp  Asp Gly Leu Asp Cys  Ala Ser Glu 
    1490                 1495                 1500             


Val Pro  Ala Leu Leu Ala Arg  Gly Val Leu Val Leu  Thr Val Leu 
    1505                 1510                 1515             


Leu Pro  Pro Glu Glu Leu Leu  Arg Ser Ser Ala Asp  Phe Leu Gln 
    1520                 1525                 1530             


Arg Leu  Ser Ala Ile Leu Arg  Thr Ser Leu Arg Phe  Arg Leu Asp 
    1535                 1540                 1545             


Ala His  Gly Gln Ala Met Val  Phe Pro Tyr His Arg  Pro Ser Pro 
    1550                 1555                 1560             


Gly Ser  Glu Pro Arg Ala Arg  Arg Glu Leu Ala Pro  Glu Val Ile 
    1565                 1570                 1575             


Gly Ser  Val Val Met Leu Glu  Ile Asp Asn Arg Leu  Cys Leu Gln 
    1580                 1585                 1590             


Ser Pro  Glu Asn Asp His Cys  Phe Pro Asp Ala Gln  Ser Ala Ala 
    1595                 1600                 1605             


Asp Tyr  Leu Gly Ala Leu Ser  Ala Val Glu Arg Leu  Asp Phe Pro 
    1610                 1615                 1620             


Tyr Pro  Leu Arg Asp Val Arg  Gly Glu Pro Leu Glu  Pro Pro Glu 
    1625                 1630                 1635             


Pro Ser  Val Pro Leu Leu Pro  Leu Leu Val Ala Gly  Ala Val Leu 
    1640                 1645                 1650             


Leu Leu  Val Ile Leu Val Leu  Gly Val Met Val Ala  Arg Arg Lys 
    1655                 1660                 1665             


Arg Glu  His Ser Thr Leu Trp  Phe Pro Glu Gly Phe  Ser Leu His 
    1670                 1675                 1680             


Lys Asp  Val Ala Ser Gly His  Lys Gly Arg Arg Glu  Pro Val Gly 
    1685                 1690                 1695             


Gln Asp  Ala Leu Gly Met Lys  Asn Met Ala Lys Gly  Glu Ser Leu 
    1700                 1705                 1710             


Met Gly  Glu Val Ala Thr Asp  Trp Met Asp Thr Glu  Cys Pro Glu 
    1715                 1720                 1725             


Ala Lys  Arg Leu Lys Val Glu  Glu Pro Gly Met Gly  Ala Glu Glu 
    1730                 1735                 1740             


Ala Val  Asp Cys Arg Gln Trp  Thr Gln His His Leu  Val Ala Ala 
    1745                 1750                 1755             


Asp Ile  Arg Val Ala Pro Ala  Met Ala Leu Thr Pro  Pro Gln Gly 
    1760                 1765                 1770             


Asp Ala  Asp Ala Asp Gly Met  Asp Val Asn Val Arg  Gly Pro Asp 
    1775                 1780                 1785             


Gly Phe  Thr Pro Leu Met Leu  Ala Ser Phe Cys Gly  Gly Ala Leu 
    1790                 1795                 1800             


Glu Pro  Met Pro Thr Glu Glu  Asp Glu Ala Asp Asp  Thr Ser Ala 
    1805                 1810                 1815             


Ser Ile  Ile Ser Asp Leu Ile  Cys Gln Gly Ala Gln  Leu Gly Ala 
    1820                 1825                 1830             


Arg Thr  Asp Arg Thr Gly Glu  Thr Ala Leu His Leu  Ala Ala Arg 
    1835                 1840                 1845             


Tyr Ala  Arg Ala Asp Ala Ala  Lys Arg Leu Leu Asp  Ala Gly Ala 
    1850                 1855                 1860             


Asp Thr  Asn Ala Gln Asp His  Ser Gly Arg Thr Pro  Leu His Thr 
    1865                 1870                 1875             


Ala Val  Thr Ala Asp Ala Gln  Gly Val Phe Gln Ile  Leu Ile Arg 
    1880                 1885                 1890             


Asn Arg  Ser Thr Asp Leu Asp  Ala Arg Met Ala Asp  Gly Ser Thr 
    1895                 1900                 1905             


Ala Leu  Ile Leu Ala Ala Arg  Leu Ala Val Glu Gly  Met Val Glu 
    1910                 1915                 1920             


Glu Leu  Ile Ala Ser His Ala  Asp Val Asn Ala Val  Asp Glu Leu 
    1925                 1930                 1935             


Gly Lys  Ser Ala Leu His Trp  Ala Ala Ala Val Asn  Asn Val Glu 
    1940                 1945                 1950             


Ala Thr  Leu Ala Leu Leu Lys  Asn Gly Ala Asn Lys  Asp Met Gln 
    1955                 1960                 1965             


Asp Ser  Lys Glu Glu Thr Pro  Leu Phe Leu Ala Ala  Arg Glu Gly 
    1970                 1975                 1980             


Ser Tyr  Glu Ala Ala Lys Leu  Leu Leu Asp His Phe  Ala Asn Arg 
    1985                 1990                 1995             


Glu Ile  Thr Asp His Leu Asp  Arg Leu Pro Arg Asp  Val Ala Gln 
    2000                 2005                 2010             


Glu Arg  Leu His Gln Asp Ile  Val Arg Leu Leu Asp  Gln Pro Ser 
    2015                 2020                 2025             


Gly Pro  Arg Ser Pro Pro Gly  Pro His Gly Leu Gly  Pro Leu Leu 
    2030                 2035                 2040             


Cys Pro  Pro Gly Ala Phe Leu  Pro Gly Leu Lys Ala  Ala Gln Ser 
    2045                 2050                 2055             


Gly Ser  Lys Lys Ser Arg Arg  Pro Pro Gly Lys Ala  Gly Leu Gly 
    2060                 2065                 2070             


Pro Gln  Gly Pro Arg Gly Arg  Gly Lys Lys Leu Thr  Leu Ala Cys 
    2075                 2080                 2085             


Pro Gly  Pro Leu Ala Asp Ser  Ser Val Thr Leu Ser  Pro Val Asp 
    2090                 2095                 2100             


Ser Leu  Asp Ser Pro Arg Pro  Phe Gly Gly Pro Pro  Ala Ser Pro 
    2105                 2110                 2115             


Gly Gly  Phe Pro Leu Glu Gly  Pro Tyr Ala Ala Ala  Thr Ala Thr 
    2120                 2125                 2130             


Ala Val  Ser Leu Ala Gln Leu  Gly Gly Pro Gly Arg  Ala Gly Leu 
    2135                 2140                 2145             


Gly Arg  Gln Pro Pro Gly Gly  Cys Val Leu Ser Leu  Gly Leu Leu 
    2150                 2155                 2160             


Asn Pro  Val Ala Val Pro Leu  Asp Trp Ala Arg Leu  Pro Pro Pro 
    2165                 2170                 2175             


Ala Pro  Pro Gly Pro Ser Phe  Leu Leu Pro Leu Ala  Pro Gly Pro 
    2180                 2185                 2190             


Gln Leu  Leu Asn Pro Gly Thr  Pro Val Ser Pro Gln  Glu Arg Pro 
    2195                 2200                 2205             


Pro Pro  Tyr Leu Ala Val Pro  Gly His Gly Glu Glu  Tyr Pro Ala 
    2210                 2215                 2220             


Ala Gly  Ala His Ser Ser Pro  Pro Lys Ala Arg Phe  Leu Arg Val 
    2225                 2230                 2235             


Pro Ser  Glu His Pro Tyr Leu  Thr Pro Ser Pro Glu  Ser Pro Glu 
    2240                 2245                 2250             


His Trp  Ala Ser Pro Ser Pro  Pro Ser Leu Ser Asp  Trp Ser Glu 
    2255                 2260                 2265             


Ser Thr  Pro Ser Pro Ala Thr  Ala Thr Gly Ala Met  Ala Thr Thr 
    2270                 2275                 2280             


Thr Gly  Ala Leu Pro Ala Gln  Pro Leu Pro Leu Ser  Val Pro Ser 
    2285                 2290                 2295             


Ser Leu  Ala Gln Ala Gln Thr  Gln Leu Gly Pro Gln  Pro Glu Val 
    2300                 2305                 2310             


Thr Pro  Lys Arg Gln Val Leu  Ala 
    2315                 2320     


<210>  28
<211>  2003
<212>  PRT
<213>  Homo sapiens

<400>  28

Met Gln Pro Pro Ser Leu Leu Leu Leu Leu Leu Leu Leu Leu Leu Leu 
1               5                   10                  15      


Cys Val Ser Val Val Arg Pro Arg Gly Leu Leu Cys Gly Ser Phe Pro 
            20                  25                  30          


Glu Pro Cys Ala Asn Gly Gly Thr Cys Leu Ser Leu Ser Leu Gly Gln 
        35                  40                  45              


Gly Thr Cys Gln Cys Ala Pro Gly Phe Leu Gly Glu Thr Cys Gln Phe 
    50                  55                  60                  


Pro Asp Pro Cys Gln Asn Ala Gln Leu Cys Gln Asn Gly Gly Ser Cys 
65                  70                  75                  80  


Gln Ala Leu Leu Pro Ala Pro Leu Gly Leu Pro Ser Ser Pro Ser Pro 
                85                  90                  95      


Leu Thr Pro Ser Phe Leu Cys Thr Cys Leu Pro Gly Phe Thr Gly Glu 
            100                 105                 110         


Arg Cys Gln Ala Lys Leu Glu Asp Pro Cys Pro Pro Ser Phe Cys Ser 
        115                 120                 125             


Lys Arg Gly Arg Cys His Ile Gln Ala Ser Gly Arg Pro Gln Cys Ser 
    130                 135                 140                 


Cys Met Pro Gly Trp Thr Gly Glu Gln Cys Gln Leu Arg Asp Phe Cys 
145                 150                 155                 160 


Ser Ala Asn Pro Cys Val Asn Gly Gly Val Cys Leu Ala Thr Tyr Pro 
                165                 170                 175     


Gln Ile Gln Cys His Cys Pro Pro Gly Phe Glu Gly His Ala Cys Glu 
            180                 185                 190         


Arg Asp Val Asn Glu Cys Phe Gln Asp Pro Gly Pro Cys Pro Lys Gly 
        195                 200                 205             


Thr Ser Cys His Asn Thr Leu Gly Ser Phe Gln Cys Leu Cys Pro Val 
    210                 215                 220                 


Gly Gln Glu Gly Pro Arg Cys Glu Leu Arg Ala Gly Pro Cys Pro Pro 
225                 230                 235                 240 


Arg Gly Cys Ser Asn Gly Gly Thr Cys Gln Leu Met Pro Glu Lys Asp 
                245                 250                 255     


Ser Thr Phe His Leu Cys Leu Cys Pro Pro Gly Phe Ile Gly Pro Asp 
            260                 265                 270         


Cys Glu Val Asn Pro Asp Asn Cys Val Ser His Gln Cys Gln Asn Gly 
        275                 280                 285             


Gly Thr Cys Gln Asp Gly Leu Asp Thr Tyr Thr Cys Leu Cys Pro Glu 
    290                 295                 300                 


Thr Trp Thr Gly Trp Asp Cys Ser Glu Asp Val Asp Glu Cys Glu Thr 
305                 310                 315                 320 


Gln Gly Pro Pro His Cys Arg Asn Gly Gly Thr Cys Gln Asn Ser Ala 
                325                 330                 335     


Gly Ser Phe His Cys Val Cys Val Ser Gly Trp Gly Gly Thr Ser Cys 
            340                 345                 350         


Glu Glu Asn Leu Asp Asp Cys Ile Ala Ala Thr Cys Ala Pro Gly Ser 
        355                 360                 365             


Thr Cys Ile Asp Arg Val Gly Ser Phe Ser Cys Leu Cys Pro Pro Gly 
    370                 375                 380                 


Arg Thr Gly Leu Leu Cys His Leu Glu Asp Met Cys Leu Ser Gln Pro 
385                 390                 395                 400 


Cys His Gly Asp Ala Gln Cys Ser Thr Asn Pro Leu Thr Gly Ser Thr 
                405                 410                 415     


Leu Cys Leu Cys Gln Pro Gly Tyr Ser Gly Pro Thr Cys His Gln Asp 
            420                 425                 430         


Leu Asp Glu Cys Leu Met Ala Gln Gln Gly Pro Ser Pro Cys Glu His 
        435                 440                 445             


Gly Gly Ser Cys Leu Asn Thr Pro Gly Ser Phe Asn Cys Leu Cys Pro 
    450                 455                 460                 


Pro Gly Tyr Thr Gly Ser Arg Cys Glu Ala Asp His Asn Glu Cys Leu 
465                 470                 475                 480 


Ser Gln Pro Cys His Pro Gly Ser Thr Cys Leu Asp Leu Leu Ala Thr 
                485                 490                 495     


Phe His Cys Leu Cys Pro Pro Gly Leu Glu Gly Gln Leu Cys Glu Val 
            500                 505                 510         


Glu Thr Asn Glu Cys Ala Ser Ala Pro Cys Leu Asn His Ala Asp Cys 
        515                 520                 525             


His Asp Leu Leu Asn Gly Phe Gln Cys Ile Cys Leu Pro Gly Phe Ser 
    530                 535                 540                 


Gly Thr Arg Cys Glu Glu Asp Ile Asp Glu Cys Arg Ser Ser Pro Cys 
545                 550                 555                 560 


Ala Asn Gly Gly Gln Cys Gln Asp Gln Pro Gly Ala Phe His Cys Lys 
                565                 570                 575     


Cys Leu Pro Gly Phe Glu Gly Pro Arg Cys Gln Thr Glu Val Asp Glu 
            580                 585                 590         


Cys Leu Ser Asp Pro Cys Pro Val Gly Ala Ser Cys Leu Asp Leu Pro 
        595                 600                 605             


Gly Ala Phe Phe Cys Leu Cys Pro Ser Gly Phe Thr Gly Gln Leu Cys 
    610                 615                 620                 


Glu Val Pro Leu Cys Ala Pro Asn Leu Cys Gln Pro Lys Gln Ile Cys 
625                 630                 635                 640 


Lys Asp Gln Lys Asp Lys Ala Asn Cys Leu Cys Pro Asp Gly Ser Pro 
                645                 650                 655     


Gly Cys Ala Pro Pro Glu Asp Asn Cys Thr Cys His His Gly His Cys 
            660                 665                 670         


Gln Arg Ser Ser Cys Val Cys Asp Val Gly Trp Thr Gly Pro Glu Cys 
        675                 680                 685             


Glu Ala Glu Leu Gly Gly Cys Ile Ser Ala Pro Cys Ala His Gly Gly 
    690                 695                 700                 


Thr Cys Tyr Pro Gln Pro Ser Gly Tyr Asn Cys Thr Cys Pro Thr Gly 
705                 710                 715                 720 


Tyr Thr Gly Pro Thr Cys Ser Glu Glu Met Thr Ala Cys His Ser Gly 
                725                 730                 735     


Pro Cys Leu Asn Gly Gly Ser Cys Asn Pro Ser Pro Gly Gly Tyr Tyr 
            740                 745                 750         


Cys Thr Cys Pro Pro Ser His Thr Gly Pro Gln Cys Gln Thr Ser Thr 
        755                 760                 765             


Asp Tyr Cys Val Ser Ala Pro Cys Phe Asn Gly Gly Thr Cys Val Asn 
    770                 775                 780                 


Arg Pro Gly Thr Phe Ser Cys Leu Cys Ala Met Gly Phe Gln Gly Pro 
785                 790                 795                 800 


Arg Cys Glu Gly Lys Leu Arg Pro Ser Cys Ala Asp Ser Pro Cys Arg 
                805                 810                 815     


Asn Arg Ala Thr Cys Gln Asp Ser Pro Gln Gly Pro Arg Cys Leu Cys 
            820                 825                 830         


Pro Thr Gly Tyr Thr Gly Gly Ser Cys Gln Thr Leu Met Asp Leu Cys 
        835                 840                 845             


Ala Gln Lys Pro Cys Pro Arg Asn Ser His Cys Leu Gln Thr Gly Pro 
    850                 855                 860                 


Ser Phe His Cys Leu Cys Leu Gln Gly Trp Thr Gly Pro Leu Cys Asn 
865                 870                 875                 880 


Leu Pro Leu Ser Ser Cys Gln Lys Ala Ala Leu Ser Gln Gly Ile Asp 
                885                 890                 895     


Val Ser Ser Leu Cys His Asn Gly Gly Leu Cys Val Asp Ser Gly Pro 
            900                 905                 910         


Ser Tyr Phe Cys His Cys Pro Pro Gly Phe Gln Gly Ser Leu Cys Gln 
        915                 920                 925             


Asp His Val Asn Pro Cys Glu Ser Arg Pro Cys Gln Asn Gly Ala Thr 
    930                 935                 940                 


Cys Met Ala Gln Pro Ser Gly Tyr Leu Cys Gln Cys Ala Pro Gly Tyr 
945                 950                 955                 960 


Asp Gly Gln Asn Cys Ser Lys Glu Leu Asp Ala Cys Gln Ser Gln Pro 
                965                 970                 975     


Cys His Asn His Gly Thr Cys Thr Pro Lys Pro Gly Gly Phe His Cys 
            980                 985                 990         


Ala Cys Pro Pro Gly Phe Val Gly  Leu Arg Cys Glu Gly  Asp Val Asp 
        995                 1000                 1005             


Glu Cys  Leu Asp Gln Pro Cys  His Pro Thr Gly Thr  Ala Ala Cys 
    1010                 1015                 1020             


His Ser  Leu Ala Asn Ala Phe  Tyr Cys Gln Cys Leu  Pro Gly His 
    1025                 1030                 1035             


Thr Gly  Gln Trp Cys Glu Val  Glu Ile Asp Pro Cys  His Ser Gln 
    1040                 1045                 1050             


Pro Cys  Phe His Gly Gly Thr  Cys Glu Ala Thr Ala  Gly Ser Pro 
    1055                 1060                 1065             


Leu Gly  Phe Ile Cys His Cys  Pro Lys Gly Phe Glu  Gly Pro Thr 
    1070                 1075                 1080             


Cys Ser  His Arg Ala Pro Ser  Cys Gly Phe His His  Cys His His 
    1085                 1090                 1095             


Gly Gly  Leu Cys Leu Pro Ser  Pro Lys Pro Gly Phe  Pro Pro Arg 
    1100                 1105                 1110             


Cys Ala  Cys Leu Ser Gly Tyr  Gly Gly Pro Asp Cys  Leu Thr Pro 
    1115                 1120                 1125             


Pro Ala  Pro Lys Gly Cys Gly  Pro Pro Ser Pro Cys  Leu Tyr Asn 
    1130                 1135                 1140             


Gly Ser  Cys Ser Glu Thr Thr  Gly Leu Gly Gly Pro  Gly Phe Arg 
    1145                 1150                 1155             


Cys Ser  Cys Pro His Ser Ser  Pro Gly Pro Arg Cys  Gln Lys Pro 
    1160                 1165                 1170             


Gly Ala  Lys Gly Cys Glu Gly  Arg Ser Gly Asp Gly  Ala Cys Asp 
    1175                 1180                 1185             


Ala Gly  Cys Ser Gly Pro Gly  Gly Asn Trp Asp Gly  Gly Asp Cys 
    1190                 1195                 1200             


Ser Leu  Gly Val Pro Asp Pro  Trp Lys Gly Cys Pro  Ser His Ser 
    1205                 1210                 1215             


Arg Cys  Trp Leu Leu Phe Arg  Asp Gly Gln Cys His  Pro Gln Cys 
    1220                 1225                 1230             


Asp Ser  Glu Glu Cys Leu Phe  Asp Gly Tyr Asp Cys  Glu Thr Pro 
    1235                 1240                 1245             


Pro Ala  Cys Thr Pro Ala Tyr  Asp Gln Tyr Cys His  Asp His Phe 
    1250                 1255                 1260             


His Asn  Gly His Cys Glu Lys  Gly Cys Asn Thr Ala  Glu Cys Gly 
    1265                 1270                 1275             


Trp Asp  Gly Gly Asp Cys Arg  Pro Glu Asp Gly Asp  Pro Glu Trp 
    1280                 1285                 1290             


Gly Pro  Ser Leu Ala Leu Leu  Val Val Leu Ser Pro  Pro Ala Leu 
    1295                 1300                 1305             


Asp Gln  Gln Leu Phe Ala Leu  Ala Arg Val Leu Ser  Leu Thr Leu 
    1310                 1315                 1320             


Arg Val  Gly Leu Trp Val Arg  Lys Asp Arg Asp Gly  Arg Asp Met 
    1325                 1330                 1335             


Val Tyr  Pro Tyr Pro Gly Ala  Arg Ala Glu Glu Lys  Leu Gly Gly 
    1340                 1345                 1350             


Thr Arg  Asp Pro Thr Tyr Gln  Glu Arg Ala Ala Pro  Gln Thr Gln 
    1355                 1360                 1365             


Pro Leu  Gly Lys Glu Thr Asp  Ser Leu Ser Ala Gly  Phe Val Val 
    1370                 1375                 1380             


Val Met  Gly Val Asp Leu Ser  Arg Cys Gly Pro Asp  His Pro Ala 
    1385                 1390                 1395             


Ser Arg  Cys Pro Trp Asp Pro  Gly Leu Leu Leu Arg  Phe Leu Ala 
    1400                 1405                 1410             


Ala Met  Ala Ala Val Gly Ala  Leu Glu Pro Leu Leu  Pro Gly Pro 
    1415                 1420                 1425             


Leu Leu  Ala Val His Pro His  Ala Gly Thr Ala Pro  Pro Ala Asn 
    1430                 1435                 1440             


Gln Leu  Pro Trp Pro Val Leu  Cys Ser Pro Val Ala  Gly Val Ile 
    1445                 1450                 1455             


Leu Leu  Ala Leu Gly Ala Leu  Leu Val Leu Gln Leu  Ile Arg Arg 
    1460                 1465                 1470             


Arg Arg  Arg Glu His Gly Ala  Leu Trp Leu Pro Pro  Gly Phe Thr 
    1475                 1480                 1485             


Arg Arg  Pro Arg Thr Gln Ser  Ala Pro His Arg Arg  Arg Pro Pro 
    1490                 1495                 1500             


Leu Gly  Glu Asp Ser Ile Gly  Leu Lys Ala Leu Lys  Pro Lys Ala 
    1505                 1510                 1515             


Glu Val  Asp Glu Asp Gly Val  Val Met Cys Ser Gly  Pro Glu Glu 
    1520                 1525                 1530             


Gly Glu  Glu Val Gly Gln Ala  Glu Glu Thr Gly Pro  Pro Ser Thr 
    1535                 1540                 1545             


Cys Gln  Leu Trp Ser Leu Ser  Gly Gly Cys Gly Ala  Leu Pro Gln 
    1550                 1555                 1560             


Ala Ala  Met Leu Thr Pro Pro  Gln Glu Ser Glu Met  Glu Ala Pro 
    1565                 1570                 1575             


Asp Leu  Asp Thr Arg Gly Pro  Asp Gly Val Thr Pro  Leu Met Ser 
    1580                 1585                 1590             


Ala Val  Cys Cys Gly Glu Val  Gln Ser Gly Thr Phe  Gln Gly Ala 
    1595                 1600                 1605             


Trp Leu  Gly Cys Pro Glu Pro  Trp Glu Pro Leu Leu  Asp Gly Gly 
    1610                 1615                 1620             


Ala Cys  Pro Gln Ala His Thr  Val Gly Thr Gly Glu  Thr Pro Leu 
    1625                 1630                 1635             


His Leu  Ala Ala Arg Phe Ser  Arg Pro Thr Ala Ala  Arg Arg Leu 
    1640                 1645                 1650             


Leu Glu  Ala Gly Ala Asn Pro  Asn Gln Pro Asp Arg  Ala Gly Arg 
    1655                 1660                 1665             


Thr Pro  Leu His Ala Ala Val  Ala Ala Asp Ala Arg  Glu Val Cys 
    1670                 1675                 1680             


Gln Leu  Leu Leu Arg Ser Arg  Gln Thr Ala Val Asp  Ala Arg Thr 
    1685                 1690                 1695             


Glu Asp  Gly Thr Thr Pro Leu  Met Leu Ala Ala Arg  Leu Ala Val 
    1700                 1705                 1710             


Glu Asp  Leu Val Glu Glu Leu  Ile Ala Ala Gln Ala  Asp Val Gly 
    1715                 1720                 1725             


Ala Arg  Asp Lys Trp Gly Lys  Thr Ala Leu His Trp  Ala Ala Ala 
    1730                 1735                 1740             


Val Asn  Asn Ala Arg Ala Ala  Arg Ser Leu Leu Gln  Ala Gly Ala 
    1745                 1750                 1755             


Asp Lys  Asp Ala Gln Asp Asn  Arg Glu Gln Thr Pro  Leu Phe Leu 
    1760                 1765                 1770             


Ala Ala  Arg Glu Gly Ala Val  Glu Val Ala Gln Leu  Leu Leu Gly 
    1775                 1780                 1785             


Leu Gly  Ala Ala Arg Glu Leu  Arg Asp Gln Ala Gly  Leu Ala Pro 
    1790                 1795                 1800             


Ala Asp  Val Ala His Gln Arg  Asn His Trp Asp Leu  Leu Thr Leu 
    1805                 1810                 1815             


Leu Glu  Gly Ala Gly Pro Pro  Glu Ala Arg His Lys  Ala Thr Pro 
    1820                 1825                 1830             


Gly Arg  Glu Ala Gly Pro Phe  Pro Arg Ala Arg Thr  Val Ser Val 
    1835                 1840                 1845             


Ser Val  Pro Pro His Gly Gly  Gly Ala Leu Pro Arg  Cys Arg Thr 
    1850                 1855                 1860             


Leu Ser  Ala Gly Ala Gly Pro  Arg Gly Gly Gly Ala  Cys Leu Gln 
    1865                 1870                 1875             


Ala Arg  Thr Trp Ser Val Asp  Leu Ala Ala Arg Gly  Gly Gly Ala 
    1880                 1885                 1890             


Tyr Ser  His Cys Arg Ser Leu  Ser Gly Val Gly Ala  Gly Gly Gly 
    1895                 1900                 1905             


Pro Thr  Pro Arg Gly Arg Arg  Phe Ser Ala Gly Met  Arg Gly Pro 
    1910                 1915                 1920             


Arg Pro  Asn Pro Ala Ile Met  Arg Gly Arg Tyr Gly  Val Ala Ala 
    1925                 1930                 1935             


Gly Arg  Gly Gly Arg Val Ser  Thr Asp Asp Trp Pro  Cys Asp Trp 
    1940                 1945                 1950             


Val Ala  Leu Gly Ala Cys Gly  Ser Ala Ser Asn Ile  Pro Ile Pro 
    1955                 1960                 1965             


Pro Pro  Cys Leu Thr Pro Ser  Pro Glu Arg Gly Ser  Pro Gln Leu 
    1970                 1975                 1980             


Asp Cys  Gly Pro Pro Ala Leu  Gln Glu Met Pro Ile  Asn Gln Gly 
    1985                 1990                 1995             


Gly Glu  Gly Lys Lys 
    2000             


<210>  29
<211>  9322
<212>  DNA
<213>  Homo sapiens

<400>  29
atgccgccgc tcctggcgcc cctgctctgc ctggcgctgc tgcccgcgct cgccgcacga       60

ggcccgcgat gctcccagcc cggtgagacc tgcctgaatg gcgggaagtg tgaagcggcc      120

aatggcacgg aggcctgcgt ctgtggcggg gccttcgtgg gcccgcgatg ccaggacccc      180

aacccgtgcc tcagcacccc ctgcaagaac gccgggacat gccacgtggt ggaccgcaga      240

ggcgtggcag actatgcctg cagctgtgcc ctgggcttct ctgggcccct ctgcctgaca      300

cccctggaca atgcctgcct caccaacccc tgccgcaacg ggggcacctg cgacctgctc      360

acgctgacgg agtacaagtg ccgctgcccg cccggctggt cagggaaatc gtgccagcag      420

gctgacccgt gcgcctccaa cccctgcgcc aacggtggcc agtgcctgcc cttcgaggcc      480

tcctacatct gccactgccc acccagcttc catggcccca cctgccggca ggatgtcaac      540

gagtgtggcc agaagcccgg gctttgccgc cacggaggca cctgccacaa cgaggtcggc      600

tcctaccgct gcgtctgccg cgccacccac actggcccca actgcgagcg gccctacgtg      660

ccctgcagcc cctcgccctg ccagaacggg ggcacctgcc gccccacggg cgacgtcacc      720

cacgagtgtg cctgcctgcc aggcttcacc ggccagaact gtgaggaaaa tatcgacgat      780

tgtccaggaa acaactgcaa gaacgggggt gcctgtgtgg acggcgtgaa cacctacaac      840

tgccgctgcc cgccagagtg gacaggtcag tactgtaccg aggatgtgga cgagtgccag      900

ctgatgccaa atgcctgcca gaacggcggg acctgccaca acacccacgg tggctacaac      960

tgcgtgtgtg tcaacggctg gactggtgag gactgcagcg agaacattga tgactgtgcc     1020

agcgccgcct gcttccacgg cgccacctgc catgaccgtg tggcctcctt ctactgcgag     1080

tgtccccatg gccgcacagg tctgctgtgc cacctcaacg acgcatgcat cagcaacccc     1140

tgtaacgagg gctccaactg cgacaccaac cctgtcaatg gcaaggccat ctgcacctgc     1200

ccctcggggt acacgggccc ggcctgcagc caggacgtgg atgagtgctc gctgggtgcc     1260

aacccctgcg agcatgcggg caagtgcatc aacacgctgg gctccttcga gtgccagtgt     1320

ctgcagggct acacgggccc ccgatgcgag atcgacgtca acgagtgcgt ctcgaacccg     1380

tgccagaacg acgccacctg cctggaccag attggggagt tccagtgcat ctgcatgccc     1440

ggctacgagg gtgtgcactg cgaggtcaac acagacgagt gtgccagcag cccctgcctg     1500

cacaatggcc gctgcctgga caagatcaat gagttccagt gcgagtgccc cacgggcttc     1560

actgggcatc tgtgccagta cgatgtggac gagtgtgcca gcaccccctg caagaatggt     1620

gccaagtgcc tggacggacc caacacttac acctgtgtgt gcacggaagg gtacacgggg     1680

acgcactgcg aggtggacat cgatgagtgc gaccccgacc cctgccacta cggctcctgc     1740

aaggacggcg tcgccacctt cacctgcctc tgccgcccag gctacacggg ccaccactgc     1800

gagaccaaca tcaacgagtg ctccagccag ccctgccgcc acgggggcac ctgccaggac     1860

cgcgacaacg cctacctctg cttctgcctg aaggggacca caggacccaa ctgcgagatc     1920

aacctggatg actgtgccag cagcccctgc gactcgggca cctgtctgga caagatcgat     1980

ggctacgagt gtgcctgtga gccgggctac acagggagca tgtgtaacat caacatcgat     2040

gagtgtgcgg gcaacccctg ccacaacggg ggcacctgcg aggacggcat caatggcttc     2100

acctgccgct gccccgaggg ctaccacgac cccacctgcc tgtctgaggt caatgagtgc     2160

aacagcaacc cctgcgtcca cggggcctgc cgggacagcc tcaacgggta caagtgcgac     2220

tgtgaccctg ggtggagtgg gaccaactgt gacatcaaca acaatgagtg tgaatccaac     2280

ccttgtgtca acggcggcac ctgcaaagac atgaccagtg gctacgtgtg cacctgccgg     2340

gagggcttca gcggtcccaa ctgccagacc aacatcaacg agtgtgcgtc caacccatgt     2400

ctgaaccagg gcacgtgtat tgacgacgtt gccgggtaca agtgcaactg cctgctgccc     2460

tacacaggtg ccacgtgtga ggtggtgctg gccccgtgtg cccccagccc ctgcagaaac     2520

ggcggggagt gcaggcaatc cgaggactat gagagcttct cctgtgtctg ccccacgggc     2580

tggcaagggc agacctgtga ggtcgacatc aacgagtgcg ttctgagccc gtgccggcac     2640

ggcgcatcct gccagaacac ccacggcggc taccgctgcc actgccaggc cggctacagt     2700

gggcgcaact gcgagaccga catcgacgac tgccggccca acccgtgtca caacgggggc     2760

tcctgcacag acggcatcaa cacggccttc tgcgactgcc tgcccggctt ccggggcact     2820

ttctgtgagg aggacatcaa cgagtgtgcc agtgacccct gccgcaacgg ggccaactgc     2880

acggactgcg tggacagcta cacgtgcacc tgccccgcag gcttcagcgg gatccactgt     2940

gagaacaaca cgcctgactg cacagagagc tcctgcttca acggtggcac ctgcgtggac     3000

ggcatcaact cgttcacctg cctgtgtcca cccggcttca cgggcagcta ctgccagcac     3060

gatgtcaatg agtgcgactc acagccctgc ctgcatggcg gcacctgtca ggacggctgc     3120

ggctcctaca ggtgcacctg cccccagggc tacactggcc ccaactgcca gaaccttgtg     3180

cactggtgtg actcctcgcc ctgcaagaac ggcggcaaat gctggcagac ccacacccag     3240

taccgctgcg agtgccccag cggctggacc ggcctttact gcgacgtgcc cagcgtgtcc     3300

tgtgaggtgg ctgcgcagcg acaaggtgtt gacgttgccc gcctgtgcca gcatggaggg     3360

ctctgtgtgg acgcgggcaa cacgcaccac tgccgctgcc aggcgggcta cacaggcagc     3420

tactgtgagg acctggtgga cgagtgctca cccagcccct gccagaacgg ggccacctgc     3480

acggactacc tgggcggcta ctcctgcaag tgcgtggccg gctaccacgg ggtgaactgc     3540

tctgaggaga tcgacgagtg cctctcccac ccctgccaga acgggggcac ctgcctcgac     3600

ctccccaaca cctacaagtg ctcctgccca cggggcactc agggtgtgca ctgtgagatc     3660

aacgtggacg actgcaatcc ccccgttgac cccgtgtccc ggagccccaa gtgctttaac     3720

aacggcacct gcgtggacca ggtgggcggc tacagctgca cctgcccgcc gggcttcgtg     3780

ggtgagcgct gtgaggggga tgtcaacgag tgcctgtcca atccctgcga cgcccgtggc     3840

acccagaact gcgtgcagcg cgtcaatgac ttccactgcg agtgccgtgc tggtcacacc     3900

gggcgccgct gcgagtccgt catcaatggc tgcaaaggca agccctgcaa gaatgggggc     3960

acctgcgccg tggcctccaa caccgcccgc gggttcatct gcaagtgccc tgcgggcttc     4020

gagggcgcca cgtgtgagaa tgacgctcgt acctgcggca gcctgcgctg cctcaacggc     4080

ggcacatgca tctccggccc gcgcagcccc acctgcctgt gcctgggccc cttcacgggc     4140

cccgaatgcc agttcccggc cagcagcccc tgcctgggcg gcaacccctg ctacaaccag     4200

gggacctgtg agcccacatc cgagagcccc ttctaccgtt gcctgtgccc cgccaaattc     4260

aacgggctct tgtgccacat cctggactac agcttcgggg gtggggccgg gcgcgacatc     4320

cccccgccgc tgatcgagga ggcgtgcgag ctgcccgagt gccaggagga cgcgggcaac     4380

aaggtctgca gcctgcagtg caacaaccac gcgtgcggct gggacggcgg tgactgctcc     4440

ctcaacttca atgacccctg gaagaactgc acgcagtctc tgcagtgctg gaagtacttc     4500

agtgacggcc actgtgacag ccagtgcaac tcagccggct gcctcttcga cggctttgac     4560

tgccagcgtg cggaaggcca gtgcaacccc ctgtacgacc agtactgcaa ggaccacttc     4620

agcgacgggc actgcgacca gggctgcaac agcgcggagt gcgagtggga cgggctggac     4680

tgtgcggagc atgtacccga gaggctggcg gccggcacgc tggtggtggt ggtgctgatg     4740

ccgccggagc agctgcgcaa cagctccttc cacttcctgc gggagctcag ccgcgtgctg     4800

cacaccaacg tggtcttcaa gcgtgacgca cacggccagc agatgatctt cccctactac     4860

ggccgcgagg aggagctgcg caagcacccc atcaagcgtg ccgccgaggg ctgggccgca     4920

cctgacgccc tgctgggcca ggtgaaggcc tcgctgctcc ctggtggcag cgagggtggg     4980

cggcggcgga gggagctgga ccccatggac gtccgcggct ccatcgtcta cctggagatt     5040

gacaaccggc agtgtgtgca ggcctcctcg cagtgcttcc agagtgccac cgacgtggcc     5100

gcattcctgg gagcgctcgc ctcgctgggc agcctcaaca tcccctacaa gatcgaggcc     5160

gtgcagagtg agaccgtgga gccgcccccg ccggcgcagc tgcacttcat gtacgtggcg     5220

gcggccgcct ttgtgcttct gttcttcgtg ggctgcgggg tgctgctgtc ccgcaagcgc     5280

cggcggcagc atggccagct ctggttccct gagggcttca aagtgtctga ggccagcaag     5340

aagaagcggc gggagcccct cggcgaggac tccgtgggcc tcaagcccct gaagaacgct     5400

tcagacggtg ccctcatgga cgacaaccag aatgagtggg gggacgagga cctggagacc     5460

aagaagttcc ggttcgagga gcccgtggtt ctgcctgacc tggacgacca gacagaccac     5520

cggcagtgga ctcagcagca cctggatgcc gctgacctgc gcatgtctgc catggccccc     5580

acaccgcccc agggtgaggt tgacgccgac tgcatggacg tcaatgtccg cgggcctgat     5640

ggcttcaccc cgctcatgat cgcctcctgc agcgggggcg gcctggagac gggcaacagc     5700

gaggaagagg aggacgcgcc ggccgtcatc tccgacttca tctaccaggg cgccagcctg     5760

cacaaccaga cagaccgcac gggcgagacc gccttgcacc tggccgcccg ctactcacgc     5820

tctgatgccg ccaagcgcct gctggaggcc agcgcagatg ccaacatcca ggacaacatg     5880

ggccgcaccc cgctgcatgc ggctgtgtct gccgacgcac aaggtgtctt ccagatcctg     5940

atccggaacc gagccacaga cctggatgcc cgcatgcatg atggcacgac gccactgatc     6000

ctggctgccc gcctggccgt ggagggcatg ctggaggacc tcatcaactc acacgccgac     6060

gtcaacgccg tagatgacct gggcaagtcc gccctgcact gggccgccgc cgtgaacaat     6120

gtggatgccg cagttgtgct cctgaagaac ggggctaaca aagatatgca gaacaacagg     6180

gaggagacac ccctgtttct ggccgcccgg gagggcagct acgagaccgc caaggtgctg     6240

ctggaccact ttgccaaccg ggacatcacg gatcatatgg accgcctgcc gcgcgacatc     6300

gcacaggagc gcatgcatca cgacatcgtg aggctgctgg acgagtacaa cctggtgcgc     6360

agcccgcagc tgcacggagc cccgctgggg ggcacgccca ccctgtcgcc cccgctctgc     6420

tcgcccaacg gctacctggg cagcctcaag cccggcgtgc agggcaagaa ggtccgcaag     6480

cccagcagca aaggcctggc ctgtggaagc aaggaggcca aggacctcaa ggcacggagg     6540

aagaagtccc aggacggcaa gggctgcctg ctggacagct ccggcatgct ctcgcccgtg     6600

gactccctgg agtcacccca tggctacctg tcagacgtgg cctcgccgcc actgctgccc     6660

tccccgttcc agcagtctcc gtccgtgccc ctcaaccacc tgcctgggat gcccgacacc     6720

cacctgggca tcgggcacct gaacgtggcg gccaagcccg agatggcggc gctgggtggg     6780

ggcggccggc tggcctttga gactggccca cctcgtctct cccacctgcc tgtggcctct     6840

ggcaccagca ccgtcctggg ctccagcagc ggaggggccc tgaatttcac tgtgggcggg     6900

tccaccagtt tgaatggtca atgcgagtgg ctgtcccggc tgcagagcgg catggtgccg     6960

aaccaataca accctctgcg ggggagtgtg gcaccaggcc ccctgagcac acaggccccc     7020

tccctgcagc atggcatggt aggcccgctg cacagtagcc ttgctgccag cgccctgtcc     7080

cagatgatga gctaccaggg cctgcccagc acccggctgg ccacccagcc tcacctggtg     7140

cagacccagc aggtgcagcc acaaaactta cagatgcagc agcagaacct gcagccagca     7200

aacatccagc agcagcaaag cctgcagccg ccaccaccac caccacagcc gcaccttggc     7260

gtgagctcag cagccagcgg ccacctgggc cggagcttcc tgagtggaga gccgagccag     7320

gcagacgtgc agccactggg ccccagcagc ctggcggtgc acactattct gccccaggag     7380

agccccgccc tgcccacgtc gctgccatcc tcgctggtcc cacccgtgac cgcagcccag     7440

ttcctgacgc ccccctcgca gcacagctac tcctcgcctg tggacaacac ccccagccac     7500

cagctacagg tgcctgagca ccccttcctc accccgtccc ctgagtcccc tgaccagtgg     7560

tccagctcgt ccccgcattc caacgtctcc gactggtccg agggcgtctc cagccctccc     7620

accagcatgc agtcccagat cgcccgcatt ccggaggcct tcaagtaaac ggcgcgcccc     7680

acgagacccc ggcttccttt cccaagcctt cgggcgtctg tgtgcgctct gtggatgcca     7740

gggccgacca gaggagcctt tttaaaacac atgtttttat acaaaataag aacgaggatt     7800

ttaatttttt ttagtattta tttatgtact tttattttac acagaaacac tgccttttta     7860

tttatatgta ctgttttatc tggccccagg tagaaacttt tatctattct gagaaaacaa     7920

gcaagttctg agagccaggg ttttcctacg taggatgaaa agattcttct gtgtttataa     7980

aatataaaca aagattcatg atttataaat gccatttatt tattgattcc ttttttcaaa     8040

atccaaaaag aaatgatgtt ggagaaggga agttgaacga gcatagtcca aaaagctcct     8100

ggggcgtcca ggccgcgccc tttccccgac gcccacccaa ccccaagcca gcccggccgc     8160

tccaccagca tcacctgcct gttaggagaa gctgcatcca gaggcaaacg gaggcaaagc     8220

tggctcacct tccgcacgcg gattaatttg catctgaaat aggaaacaag tgaaagcata     8280

tgggttagat gttgccatgt gttttagatg gtttcttgca agcatgcttg tgaaaatgtg     8340

ttctcggagt gtgtatgcca agagtgcacc catggtacca atcatgaatc tttgtttcag     8400

gttcagtatt atgtagttgt tcgttggtta tacaagttct tggtccctcc agaaccaccc     8460

cggccccctg cccgttcttg aaatgtaggc atcatgcatg tcaaacatga gatgtgtgga     8520

ctgtggcact tgcctgggtc acacacggag gcatcctacc cttttctggg gaaagacact     8580

gcctgggctg accccggtgg cggccccagc acctcagcct gcacagtgtc ccccaggttc     8640

cgaagaagat gctccagcaa cacagcctgg gccccagctc gcgggacccg accccccgtg     8700

ggctcccgtg ttttgtagga gacttgccag agccgggcac attgagctgt gcaacgccgt     8760

gggctgcgtc ctttggtcct gtccccgcag ccctggcagg gggcatgcgg tcgggcaggg     8820

gctggaggga ggcgggggct gcccttgggc cacccctcct agtttgggag gagcagattt     8880

ttgcaatacc aagtatagcc tatggcagaa aaaatgtctg taaatatgtt tttaaaggtg     8940

gattttgttt aaaaaatctt aatgaatgag tctgttgtgt gtcatgccag tgagggacgt     9000

cagacttggc tcagctcggg gagccttagc cgcccatgca ctggggacgc tccgctgccg     9060

tgccgcctgc actcctcagg gcagcctccc ccggctctac gggggccgcg tggtgccatc     9120

cccagggggc atgaccagat gcgtcccaag atgttgattt ttactgtgtt ttataaaata     9180

gagtgtagtt tacagaaaaa gactttaaaa gtgatctaca tgaggaactg tagatgatgt     9240

atttttttca tcttttttgt taactgattt gcaataaaaa tgatactgat ggtgatctgg     9300

cttccaaaaa aaaaaaaaaa aa                                              9322


<210>  30
<211>  11474
<212>  DNA
<213>  Homo sapiens

<400>  30
gcttgcggtg ggaggaggcg gctgaggcgg aaggacacac gaggctgctt cgttgcacac       60

ccgagaaagt ttcagccaaa cttcgggcgg cggctgaggc ggcggccgag gagcggcgga      120

ctcggggcgc ggggagtcga ggcatttgcg cctgggcttc ggagcgtagc gccagggcct      180

gagcctttga agcaggagga ggggaggaga gagtggggct cctctatcgg gaccccctcc      240

ccatgtggat ctgcccaggc ggcggcggcg gcggcggagg aggaggcgac cgagaagatg      300

cccgccctgc gccccgctct gctgtgggcg ctgctggcgc tctggctgtg ctgcgcggcc      360

cccgcgcatg cattgcagtg tcgagatggc tatgaaccct gtgtaaatga aggaatgtgt      420

gttacctacc acaatggcac aggatactgc aaatgtccag aaggcttctt gggggaatat      480

tgtcaacatc gagacccctg tgagaagaac cgctgccaga atggtgggac ttgtgtggcc      540

caggccatgc tggggaaagc cacgtgccga tgtgcctcag ggtttacagg agaggactgc      600

cagtactcaa catctcatcc atgctttgtg tctcgaccct gcctgaatgg cggcacatgc      660

catatgctca gccgggatac ctatgagtgc acctgtcaag tcgggtttac aggtaaggag      720

tgccaatgga cggatgcctg cctgtctcat ccctgtgcaa atggaagtac ctgtaccact      780

gtggccaacc agttctcctg caaatgcctc acaggcttca cagggcagaa atgtgagact      840

gatgtcaatg agtgtgacat tccaggacac tgccagcatg gtggcacctg cctcaacctg      900

cctggttcct accagtgcca gtgccctcag ggcttcacag gccagtactg tgacagcctg      960

tatgtgccct gtgcaccctc accttgtgtc aatggaggca cctgtcggca gactggtgac     1020

ttcacttttg agtgcaactg ccttccaggt tttgaaggga gcacctgtga gaggaatatt     1080

gatgactgcc ctaaccacag gtgtcagaat ggaggggttt gtgtggatgg ggtcaacact     1140

tacaactgcc gctgtccccc acaatggaca ggacagttct gcacagagga tgtggatgaa     1200

tgcctgctgc agcccaatgc ctgtcaaaat gggggcacct gtgccaaccg caatggaggc     1260

tatggctgtg tatgtgtcaa cggctggagt ggagatgact gcagtgagaa cattgatgat     1320

tgtgccttcg cctcctgtac tccaggctcc acctgcatcg accgtgtggc ctccttctct     1380

tgcatgtgcc cagaggggaa ggcaggtctc ctgtgtcatc tggatgatgc atgcatcagc     1440

aatccttgcc acaagggggc actgtgtgac accaaccccc taaatgggca atatatttgc     1500

acctgcccac aaggctacaa aggggctgac tgcacagaag atgtggatga atgtgccatg     1560

gccaatagca atccttgtga gcatgcagga aaatgtgtga acacggatgg cgccttccac     1620

tgtgagtgtc tgaagggtta tgcaggacct cgttgtgaga tggacatcaa tgagtgccat     1680

tcagacccct gccagaatga tgctacctgt ctggataaga ttggaggctt cacatgtctg     1740

tgcatgccag gtttcaaagg tgtgcattgt gaattagaaa taaatgaatg tcagagcaac     1800

ccttgtgtga acaatgggca gtgtgtggat aaagtcaatc gtttccagtg cctgtgtcct     1860

cctggtttca ctgggccagt ttgccagatt gatattgatg actgttccag tactccgtgt     1920

ctgaatgggg caaagtgtat cgatcacccg aatggctatg aatgccagtg tgccacaggt     1980

ttcactggtg tgttgtgtga ggagaacatt gacaactgtg accccgatcc ttgccaccat     2040

ggtcagtgtc aggatggtat tgattcctac acctgcatct gcaatcccgg gtacatgggc     2100

gccatctgca gtgaccagat tgatgaatgt tacagcagcc cttgcctgaa cgatggtcgc     2160

tgcattgacc tggtcaatgg ctaccagtgc aactgccagc caggcacgtc aggggttaat     2220

tgtgaaatta attttgatga ctgtgcaagt aacccttgta tccatggaat ctgtatggat     2280

ggcattaatc gctacagttg tgtctgctca ccaggattca cagggcagag atgtaacatt     2340

gacattgatg agtgtgcctc caatccctgt cgcaagggtg caacatgtat caacggtgtg     2400

aatggtttcc gctgtatatg ccccgaggga ccccatcacc ccagctgcta ctcacaggtg     2460

aacgaatgcc tgagcaatcc ctgcatccat ggaaactgta ctggaggtct cagtggatat     2520

aagtgtctct gtgatgcagg ctgggttggc atcaactgtg aagtggacaa aaatgaatgc     2580

ctttcgaatc catgccagaa tggaggaact tgtgacaatc tggtgaatgg atacaggtgt     2640

acttgcaaga agggctttaa aggctataac tgccaggtga atattgatga atgtgcctca     2700

aatccatgcc tgaaccaagg aacctgcttt gatgacataa gtggctacac ttgccactgt     2760

gtgctgccat acacaggcaa gaattgtcag acagtattgg ctccctgttc cccaaaccct     2820

tgtgagaatg ctgctgtttg caaagagtca ccaaattttg agagttatac ttgcttgtgt     2880

gctcctggct ggcaaggtca gcggtgtacc attgacattg acgagtgtat ctccaagccc     2940

tgcatgaacc atggtctctg ccataacacc cagggcagct acatgtgtga atgtccacca     3000

ggcttcagtg gtatggactg tgaggaggac attgatgact gccttgccaa tccttgccag     3060

aatggaggtt cctgtatgga tggagtgaat actttctcct gcctctgcct tccgggtttc     3120

actggggata agtgccagac agacatgaat gagtgtctga gtgaaccctg taagaatgga     3180

gggacctgct ctgactacgt caacagttac acttgcaagt gccaggcagg atttgatgga     3240

gtccattgtg agaacaacat caatgagtgc actgagagct cctgtttcaa tggtggcaca     3300

tgtgttgatg ggattaactc cttctcttgc ttgtgccctg tgggtttcac tggatccttc     3360

tgcctccatg agatcaatga atgcagctct catccatgcc tgaatgaggg aacgtgtgtt     3420

gatggcctgg gtacctaccg ctgcagctgc cccctgggct acactgggaa aaactgtcag     3480

accctggtga atctctgcag tcggtctcca tgtaaaaaca aaggtacttg cgttcagaaa     3540

aaagcagagt cccagtgcct atgtccatct ggatgggctg gtgcctattg tgacgtgccc     3600

aatgtctctt gtgacatagc agcctccagg agaggtgtgc ttgttgaaca cttgtgccag     3660

cactcaggtg tctgcatcaa tgctggcaac acgcattact gtcagtgccc cctgggctat     3720

actgggagct actgtgagga gcaactcgat gagtgtgcgt ccaacccctg ccagcacggg     3780

gcaacatgca gtgacttcat tggtggatac agatgcgagt gtgtcccagg ctatcagggt     3840

gtcaactgtg agtatgaagt ggatgagtgc cagaatcagc cctgccagaa tggaggcacc     3900

tgtattgacc ttgtgaacca tttcaagtgc tcttgcccac caggcactcg gggcctactc     3960

tgtgaagaga acattgatga ctgtgcccgg ggtccccatt gccttaatgg tggtcagtgc     4020

atggatagga ttggaggcta cagttgtcgc tgcttgcctg gctttgctgg ggagcgttgt     4080

gagggagaca tcaacgagtg cctctccaac ccctgcagct ctgagggcag cctggactgt     4140

atacagctca ccaatgacta cctgtgtgtt tgccgtagtg cctttactgg ccggcactgt     4200

gaaaccttcg tcgatgtgtg tccccagatg ccctgcctga atggagggac ttgtgctgtg     4260

gccagtaaca tgcctgatgg tttcatttgc cgttgtcccc cgggattttc cggggcaagg     4320

tgccagagca gctgtggaca agtgaaatgt aggaaggggg agcagtgtgt gcacaccgcc     4380

tctggacccc gctgcttctg ccccagtccc cgggactgcg agtcaggctg tgccagtagc     4440

ccctgccagc acgggggcag ctgccaccct cagcgccagc ctccttatta ctcctgccag     4500

tgtgccccac cattctcggg tagccgctgt gaactctaca cggcaccccc cagcacccct     4560

cctgccacct gtctgagcca gtattgtgcc gacaaagctc gggatggcgt ctgtgatgag     4620

gcctgcaaca gccatgcctg ccagtgggat gggggtgact gttctctcac catggagaac     4680

ccctgggcca actgctcctc cccacttccc tgctgggatt atatcaacaa ccagtgtgat     4740

gagctgtgca acacggtcga gtgcctgttt gacaactttg aatgccaggg gaacagcaag     4800

acatgcaagt atgacaaata ctgtgcagac cacttcaaag acaaccactg tgaccagggg     4860

tgcaacagtg aggagtgtgg ttgggatggg ctggactgtg ctgctgacca acctgagaac     4920

ctggcagaag gtaccctggt tattgtggta ttgatgccac ctgaacaact gctccaggat     4980

gctcgcagct tcttgcgggc actgggtacc ctgctccaca ccaacctgcg cattaagcgg     5040

gactcccagg gggaactcat ggtgtacccc tattatggtg agaagtcagc tgctatgaag     5100

aaacagagga tgacacgcag atcccttcct ggtgaacaag aacaggaggt ggctggctct     5160

aaagtctttc tggaaattga caaccgccag tgtgttcaag actcagacca ctgcttcaag     5220

aacacggatg cagcagcagc tctcctggcc tctcacgcca tacaggggac cctgtcatac     5280

cctcttgtgt ctgtcgtcag tgaatccctg actccagaac gcactcagct cctctatctc     5340

cttgctgttg ctgttgtcat cattctgttt attattctgc tgggggtaat catggcaaaa     5400

cgaaagcgta agcatggctc tctctggctg cctgaaggtt tcactcttcg ccgagatgca     5460

agcaatcaca agcgtcgtga gccagtggga caggatgctg tggggctgaa aaatctctca     5520

gtgcaagtct cagaagctaa cctaattggt actggaacaa gtgaacactg ggtcgatgat     5580

gaagggcccc agccaaagaa agtaaaggct gaagatgagg ccttactctc agaagaagat     5640

gaccccattg atcgacggcc atggacacag cagcaccttg aagctgcaga catccgtagg     5700

acaccatcgc tggctctcac ccctcctcag gcagagcagg aggtggatgt gttagatgtg     5760

aatgtccgtg gcccagatgg ctgcacccca ttgatgttgg cttctctccg aggaggcagc     5820

tcagatttga gtgatgaaga tgaagatgca gaggactctt ctgctaacat catcacagac     5880

ttggtctacc agggtgccag cctccaggcc cagacagacc ggactggtga gatggccctg     5940

caccttgcag cccgctactc acgggctgat gctgccaagc gtctcctgga tgcaggtgca     6000

gatgccaatg cccaggacaa catgggccgc tgtccactcc atgctgcagt ggcagctgat     6060

gcccaaggtg tcttccagat tctgattcgc aaccgagtaa ctgatctaga tgccaggatg     6120

aatgatggta ctacacccct gatcctggct gcccgcctgg ctgtggaggg aatggtggca     6180

gaactgatca actgccaagc ggatgtgaat gcagtggatg accatggaaa atctgctctt     6240

cactgggcag ctgctgtcaa taatgtggag gcaactcttt tgttgttgaa aaatggggcc     6300

aaccgagaca tgcaggacaa caaggaagag acacctctgt ttcttgctgc ccgggagggg     6360

agctatgaag cagccaagat cctgttagac cattttgcca atcgagacat cacagaccat     6420

atggatcgtc ttccccggga tgtggctcgg gatcgcatgc accatgacat tgtgcgcctt     6480

ctggatgaat acaatgtgac cccaagccct ccaggcaccg tgttgacttc tgctctctca     6540

cctgtcatct gtgggcccaa cagatctttc ctcagcctga agcacacccc aatgggcaag     6600

aagtctagac ggcccagtgc caagagtacc atgcctacta gcctccctaa ccttgccaag     6660

gaggcaaagg atgccaaggg tagtaggagg aagaagtctc tgagtgagaa ggtccaactg     6720

tctgagagtt cagtaacttt atcccctgtt gattccctag aatctcctca cacgtatgtt     6780

tccgacacca catcctctcc aatgattaca tcccctggga tcttacaggc ctcacccaac     6840

cctatgttgg ccactgccgc ccctcctgcc ccagtccatg cccagcatgc actatctttt     6900

tctaaccttc atgaaatgca gcctttggca catggggcca gcactgtgct tccctcagtg     6960

agccagttgc tatcccacca ccacattgtg tctccaggca gtggcagtgc tggaagcttg     7020

agtaggctcc atccagtccc agtcccagca gattggatga accgcatgga ggtgaatgag     7080

acccagtaca atgagatgtt tggtatggtc ctggctccag ctgagggcac ccatcctggc     7140

atagctcccc agagcaggcc acctgaaggg aagcacataa ccacccctcg ggagcccttg     7200

ccccccattg tgactttcca gctcatccct aaaggcagta ttgcccaacc agcgggggct     7260

ccccagcctc agtccacctg ccctccagct gttgcgggcc ccctgcccac catgtaccag     7320

attccagaaa tggcccgttt gcccagtgtg gctttcccca ctgccatgat gccccagcag     7380

gacgggcagg tagctcagac cattctccca gcctatcatc ctttcccagc ctctgtgggc     7440

aagtacccca cacccccttc acagcacagt tatgcttcct caaatgctgc tgagcgaaca     7500

cccagtcaca gtggtcacct ccagggtgag catccctacc tgacaccatc cccagagtct     7560

cctgaccagt ggtcaagttc atcaccccac tctgcttctg actggtcaga tgtgaccacc     7620

agccctaccc ctgggggtgc tggaggaggt cagcggggac ctgggacaca catgtctgag     7680

ccaccacaca acaacatgca ggtttatgcg tgagagagtc cacctccagt gtagagacat     7740

aactgacttt tgtaaatgct gctgaggaac aaatgaaggt catccgggag agaaatgaag     7800

aaatctctgg agccagcttc tagaggtagg aaagagaaga tgttcttatt cagataatgc     7860

aagagaagca attcgtcagt ttcactgggt atctgcaagg cttattgatt attctaatct     7920

aataagacaa gtttgtggaa atgcaagatg aatacaagcc ttgggtccat gtttactctc     7980

ttctatttgg agaataagat ggatgcttat tgaagcccag acattcttgc agcttggact     8040

gcattttaag ccctgcaggc ttctgccata tccatgagaa gattctacac tagcgtcctg     8100

ttgggaatta tgccctggaa ttctgcctga attgacctac gcatctcctc ctccttggac     8160

attcttttgt cttcatttgg tgcttttggt tttgcacctc tccgtgattg tagccctacc     8220

agcatgttat agggcaagac ctttgtgctt ttgatcattc tggcccatga aagcaacttt     8280

ggtctccttt cccctcctgt cttcccggta tcccttggag tctcacaagg tttactttgg     8340

tatggttctc agcacaaacc tttcaagtat gttgtttctt tggaaaatgg acatactgta     8400

ttgtgttctc ctgcatatat cattcctgga gagagaaggg gagaagaata cttttcttca     8460

acaaattttg ggggcaggag atcccttcaa gaggctgcac cttaattttt cttgtctgtg     8520

tgcaggtctt catataaact ttaccaggaa gaagggtgtg agtttgttgt ttttctgtgt     8580

atgggcctgg tcagtgtaaa gttttatcct tgatagtcta gttactatga ccctccccac     8640

ttttttaaaa ccagaaaaag gtttggaatg ttggaatgac caagagacaa gttaactcgt     8700

gcaagagcca gttacccacc cacaggtccc cctacttcct gccaagcatt ccattgactg     8760

cctgtatgga acacatttgt cccagatctg agcattctag gcctgtttca ctcactcacc     8820

cagcatatga aactagtctt aactgttgag cctttccttt catatccaca gaagacactg     8880

tctcaaatgt tgtacccttg ccatttagga ctgaactttc cttagcccaa gggacccagt     8940

gacagttgtc ttccgtttgt cagatgatca gtctctactg attatcttgc tgcttaaagg     9000

cctgctcacc aatctttctt tcacaccgtg tggtccgtgt tactggtata cccagtatgt     9060

tctcactgaa gacatggact ttatatgttc aagtgcagga attggaaagt tggacttgtt     9120

ttctatgatc caaaacagcc ctataagaag gttggaaaag gaggaactat atagcagcct     9180

ttgctatttt ctgctaccat ttcttttcct ctgaagcggc catgacattc cctttggcaa     9240

ctaacgtaga aactcaacag aacattttcc tttcctagag tcacctttta gatgataatg     9300

gacaactata gacttgctca ttgttcagac tgattgcccc tcacctgaat ccactctctg     9360

tattcatgct cttggcaatt tctttgactt tcttttaagg gcagaagcat tttagttaat     9420

tgtagataaa gaatagtttt cttcctcttc tccttgggcc agttaataat tggtccatgg     9480

ctacactgca acttccgtcc agtgctgtga tgcccatgac acctgcaaaa taagttctgc     9540

ctgggcattt tgtagatatt aacaggtgaa ttcccgactc ttttggtttg aatgacagtt     9600

ctcattcctt ctatggctgc aagtatgcat cagtgcttcc cacttacctg atttgtctgt     9660

cggtggcccc atatggaaac cctgcgtgtc tgttggcata atagtttaca aatggttttt     9720

tcagtcctat ccaaatttat tgaaccaaca aaaataatta cttctgccct gagataagca     9780

gattaagttt gttcattctc tgctttattc tctccatgtg gcaacattct gtcagcctct     9840

ttcatagtgt gcaaacattt tatcattcta aatggtgact ctctgccctt ggacccattt     9900

attattcaca gatggggaga acctatctgc atggacctct gtggaccaca gcgtacctgc     9960

ccctttctgc cctcctgctc cagccccact tctgaaagta tcagctactg atccagccac    10020

tggatatttt atatcctccc ttttccttaa gcacaatgtc agaccaaatt gcttgtttct    10080

ttttcttgga ctactttaat ttggatcctt tgggtttgga gaaagggaat gtgaaagctg    10140

tcattacaga caacaggttt cagtgatgag gaggacaaca ctgcctttca aactttttac    10200

tgatctctta gattttaaga actcttgaat tgtgtggtat ctaataaaag ggaaggtaag    10260

atggataatc actttctcat ttgggttctg aattggagac tcagttttta tgagacacat    10320

cttttatgcc atgtatagat cctcccctgc tatttttggt ttatttttat tgttataaat    10380

gctttctttc tttgactcct cttctgcctg cctttgggga taggtttttt tgtttgttta    10440

tttgcttcct ctgttttgtt ttaagcatca ttttcttatg tgaggtgggg aagggaaagg    10500

tatgagggaa agagagtctg agaattaaaa tattttagta taagcaattg gctgtgatgc    10560

tcaaatccat tgcatcctct tattgaattt gccaatttgt aatttttgca taataaagaa    10620

ccaaaggtgt aatgttttgt tgagaggtgg tttagggatt ttggccctaa ccaatacatt    10680

gaatgtatga tgactatttg ggaggacaca tttatgtacc cagaggcccc cactaataag    10740

tggtactatg gttacttcct tgtgtacatt tctcttaaaa gtgatattat atctgtttgt    10800

atgagaaacc cagtaaccaa taaaatgacc gcatattcct gactaaacgt agtaaggaaa    10860

atgcacactt tgtttttact tttccgtttc attctaaagg tagttaagat gaaatttata    10920

tgaaagcatt tttatcacaa aataaaaaag gtttgccaag ctcagtggtg ttgtattttt    10980

tattttccaa tactgcatcc atggcctggc agtgttacct catgatgtca taatttgctg    11040

agagagcaaa ttttcttttc tttctgaatc ccacaaagcc tagcaccaaa cttctttttt    11100

tcttccttta attagatcat aaataaatga tcctggggaa aaagcatctg tcaaatagga    11160

aacatcacaa aactgagcac tcttctgtgc actagccata gctggtgaca aacagatggt    11220

tgctcaggga caaggtgcct tccaatggaa atgcgaagta gttgctatag caagaattgg    11280

gaactgggat ataagtcata atattaatta tgctgttatg taaatgattg gtttgtaaca    11340

ttccttaagt gaaatttgtg tagaacttaa tatacaggat tataaaataa tattttgtgt    11400

ataaatttgt tataagttca cattcataca tttatttata aagtcagtga gatatttgaa    11460

catgaaaaaa aaaa                                                      11474


<210>  31
<211>  4326
<212>  DNA
<213>  Homo sapiens

<400>  31
gcttgcggtg ggaggaggcg gctgaggcgg aaggacacac gaggctgctt cgttgcacac       60

ccgagaaagt ttcagccaaa cttcgggcgg cggctgaggc ggcggccgag gagcggcgga      120

ctcggggcgc ggggagtcga ggcatttgcg cctgggcttc ggagcgtagc gccagggcct      180

gagcctttga agcaggagga ggggaggaga gagtggggct cctctatcgg gaccccctcc      240

ccatgtggat ctgcccaggc ggcggcggcg gcggcggagg aggaggcgac cgagaagatg      300

cccgccctgc gccccgctct gctgtgggcg ctgctggcgc tctggctgtg ctgcgcggcc      360

cccgcgcatg cattgcagtg tcgagatggc tatgaaccct gtgtaaatga aggaatgtgt      420

gttacctacc acaatggcac aggatactgc aaatgtccag aaggcttctt gggggaatat      480

tgtcaacatc gagacccctg tgagaagaac cgctgccaga atggtgggac ttgtgtggcc      540

caggccatgc tggggaaagc cacgtgccga tgtgcctcag ggtttacagg agaggactgc      600

cagtactcaa catctcatcc atgctttgtg tctcgaccct gcctgaatgg cggcacatgc      660

catatgctca gccgggatac ctatgagtgc acctgtcaag tcgggtttac aggtaaggag      720

tgccaatgga cggatgcctg cctgtctcat ccctgtgcaa atggaagtac ctgtaccact      780

gtggccaacc agttctcctg caaatgcctc acaggcttca cagggcagaa atgtgagact      840

gatgtcaatg agtgtgacat tccaggacac tgccagcatg gtggcacctg cctcaacctg      900

cctggttcct accagtgcca gtgccctcag ggcttcacag gccagtactg tgacagcctg      960

tatgtgccct gtgcaccctc accttgtgtc aatggaggca cctgtcggca gactggtgac     1020

ttcacttttg agtgcaactg ccttccaggt tttgaaggga gcacctgtga gaggaatatt     1080

gatgactgcc ctaaccacag gtgtcagaat ggaggggttt gtgtggatgg ggtcaacact     1140

tacaactgcc gctgtccccc acaatggaca ggacagttct gcacagagga tgtggatgaa     1200

tgcctgctgc agcccaatgc ctgtcaaaat gggggcacct gtgccaaccg caatggaggc     1260

tatggctgtg tatgtgtcaa cggctggagt ggagatgact gcagtgagaa cattgatgat     1320

tgtgccttcg cctcctgtac tccaggctcc acctgcatcg accgtgtggc ctccttctct     1380

tgcatgtgcc cagaggggaa ggcaggtctc ctgtgtcatc tggatgatgc atgcatcagc     1440

aatccttgcc acaagggggc actgtgtgac accaaccccc taaatgggca atatatttgc     1500

acctgcccac aaggctacaa aggggctgac tgcacagaag atgtggatga atgtgccatg     1560

gccaatagca atccttgtga gcatgcagga aaatgtgtga acacggatgg cgccttccac     1620

tgtgagtgtc tgaagggtta tgcaggacct cgttgtgaga tggacatcaa tgagtgccat     1680

tcagacccct gccagaatga tgctacctgt ctggataaga ttggaggctt cacatgtctg     1740

tgcatgccag gtttcaaagg tgtgcattgt gaattagaaa taaatgaatg tcagagcaac     1800

ccttgtgtga acaatgggca gtgtgtggat aaagtcaatc gtttccagtg cctgtgtcct     1860

cctggtttca ctgggccagt ttgccagatt gatattgatg actgttccag tactccgtgt     1920

ctgaatgggg caaagtgtat cgatcacccg aatggctatg aatgccagtg tgccacaggt     1980

ttcactggtg tgttgtgtga ggagaacatt gacaactgtg accccgatcc ttgccaccat     2040

ggtcagtgtc aggatggtat tgattcctac acctgcatct gcaatcccgg gtacatgggc     2100

gccatctgca gtgaccagat tgatgaatgt tacagcagcc cttgcctgaa cgatggtcgc     2160

tgcattgacc tggtcaatgg ctaccagtgc aactgccagc caggcacgtc aggggttaat     2220

tgtgaaatta attttgatga ctgtgcaagt aacccttgta tccatggaat ctgtatggat     2280

ggcattaatc gctacagttg tgtctgctca ccaggattca cagggcagag atgtaacatt     2340

gacattgatg agtgtgcctc caatccctgt cgcaagggtg caacatgtat caacggtgtg     2400

aatggtttcc gctgtatatg ccccgaggga ccccatcacc ccagctgcta ctcacaggtg     2460

aacgaatgcc tgagcaatcc ctgcatccat ggaaactgta ctggaggtct cagtggatat     2520

aagtgtctct gtgatgcagg ctgggttggc atcaactgtg aagtggacaa aaatgaatgc     2580

ctttcgaatc catgccagaa tggaggaact tgtgacaatc tggtgaatgg atacaggtgt     2640

acttgcaaga agggctttaa aggctataac tgccaggtga atattgatga atgtgcctca     2700

aatccatgcc tgaaccaagg aacctgcttt gatgacataa gtggctacac ttgccactgt     2760

gtgctgccat acacaggcaa gaattgtcag acagtattgg ctccctgttc cccaaaccct     2820

tgtgagaatg ctgctgtttg caaagagtca ccaaattttg agagttatac ttgcttgtgt     2880

gctcctggct ggcaaggtca gcggtgtacc attgacattg acgagtgtat ctccaagccc     2940

tgcatgaacc atggtctctg ccataacacc cagggcagct acatgtgtga atgtccacca     3000

ggcttcagtg gtatggactg tgaggaggac attgatgact gccttgccaa tccttgccag     3060

aatggaggtt cctgtatgga tggagtgaat actttctcct gcctctgcct tccgggtttc     3120

actggggata agtgccagac agacatgaat gagtgtctga gtgaaccctg taagaatgga     3180

gggacctgct ctgactacgt caacagttac acttgcaagt gccaggcagg atttgatgga     3240

gtccattgtg agaacaacat caatgagtgc actgagagct cctgtttcaa tggtggcaca     3300

tgtgttgatg ggattaactc cttctcttgc ttgtgccctg tgggtttcac tggatccttc     3360

tgcctccatg agatcaatga atgcagctct catccatgcc tgaatgaggg aacgtgtgtt     3420

gatggcctgg gtacctaccg ctgcagctgc cccctgggct acactgggaa aaactgtcag     3480

accctggtga atctctgcag tcggtctcca tgtaaaaaca aaggtacttg cgttcagaaa     3540

aaagcagagt cccagtgcct atgtccatct ggatgggctg gtgcctattg tgacgtgccc     3600

aatgtctctt gtgacatagc agcctccagg agaggtgtgc ttgttgaaca cttgtgccag     3660

cactcaggtg tctgcatcaa tgctggcaac acgcattact gtcagtgccc cctgggctat     3720

actgggagct actgtgagga gcaactcgat gagtgtgcgt ccaacccctg ccagcacggg     3780

gcaacatgca gtgacttcat tggtggatac agatgcgagt gtgtcccagg ctatcagggt     3840

gtcaactgtg agtatgaagt ggatgagtgc cagaatcagc cctgccagaa tggaggcacc     3900

tgtattgacc ttgtgaacca tttcaagtgc tcttgcccac caggcactcg gggtatgaaa     3960

tcatccttat ccattttcca tccagggcat tgtcttaagt tataaatcca ttcttagtgt     4020

tcaggggatt ttataaaatt aaagatagga agactagctt cattccaagc atttagttct     4080

acatcctagt aattcaagcc attttattct cccatctctt gctagctctg atgttgtggt     4140

ttatgttgtc agttttatct ggttgtttgg catcttgata ttccatgaaa cacagaatat     4200

ggaagggata caacattagc ataacattaa aaaattagcc tggtcagtaa gatttcttgt     4260

tgcttcacag aaaagcaact aatggcctct aaaataaaca atttacattt aaaaaaaaaa     4320

aaaaaa                                                                4326


<210>  32
<211>  8089
<212>  DNA
<213>  Homo sapiens

<400>  32
gcggcgcgga ggctggcccg ggacgcgccc ggagcccagg gaaggaggga ggaggggagg       60

gtcgcggccg gccgccatgg ggccgggggc ccgtggccgc cgccgccgcc gtcgcccgat      120

gtcgccgcca ccgccaccgc cacccgtgcg ggcgctgccc ctgctgctgc tgctagcggg      180

gccgggggct gcagcccccc cttgcctgga cggaagcccg tgtgcaaatg gaggtcgttg      240

cacccagctg ccctcccggg aggctgcctg cctgtgcccg cctggctggg tgggtgagcg      300

gtgtcagctg gaggacccct gtcactcagg cccctgtgct ggccgtggtg tctgccagag      360

ttcagtggtg gctggcaccg cccgattctc atgccggtgc ccccgtggct tccgaggccc      420

tgactgctcc ctgccagatc cctgcctcag cagcccttgt gcccacggtg cccgctgctc      480

agtggggccc gatggacgct tcctctgctc ctgcccacct ggctaccagg gccgcagctg      540

ccgaagcgac gtggatgagt gccgggtggg tgagccctgc cgccatggtg gcacctgcct      600

caacacacct ggctccttcc gctgccagtg tccagctggc tacacagggc cactatgtga      660

gaaccccgcg gtgccctgtg caccctcacc atgccgtaac gggggcacct gcaggcagag      720

tggcgacctc acttacgact gtgcctgtct tcctgggttt gagggtcaga attgtgaagt      780

gaacgtggac gactgtccag gacaccgatg tctcaatggg gggacatgcg tggatggcgt      840

caacacctat aactgccagt gccctcctga gtggacaggc cagttctgca cggaggacgt      900

ggatgagtgt cagctgcagc ccaacgcctg ccacaatggg ggtacctgct tcaacacgct      960

gggtggccac agctgcgtgt gtgtcaatgg ctggacaggc gagagctgca gtcagaatat     1020

cgatgactgt gccacagccg tgtgcttcca tggggccacc tgccatgacc gcgtggcttc     1080

tttctactgt gcctgcccca tgggcaagac tggcctcctg tgtcacctgg atgacgcctg     1140

tgtcagcaac ccctgccacg aggatgctat ctgtgacaca aatccggtga acggccgggc     1200

catttgcacc tgtcctcccg gcttcacggg tggggcatgt gaccaggatg tggacgagtg     1260

ctctatcggc gccaacccct gcgagcactt gggcaggtgc gtgaacacgc agggctcctt     1320

cctgtgccag tgcggtcgtg gctacactgg acctcgctgt gagaccgatg tcaacgagtg     1380

tctgtcgggg ccctgccgaa accaggccac gtgcctcgac cgcataggcc agttcacctg     1440

tatctgtatg gcaggcttca caggaaccta ttgcgaggtg gacattgacg agtgtcagag     1500

tagcccctgt gtcaacggtg gggtctgcaa ggaccgagtc aatggcttca gctgcacctg     1560

cccctcgggc ttcagcggct ccacgtgtca gctggacgtg gacgaatgcg ccagcacgcc     1620

ctgcaggaat ggcgccaaat gcgtggacca gcccgatggc tacgagtgcc gctgtgccga     1680

gggctttgag ggcacgctgt gtgatcgcaa cgtggacgac tgctcccctg acccatgcca     1740

ccatggtcgc tgcgtggatg gcatcgccag cttctcatgt gcctgtgctc ctggctacac     1800

gggcacacgc tgcgagagcc aggtggacga atgccgcagc cagccctgcc gccatggcgg     1860

caaatgccta gacctggtgg acaagtacct ctgccgctgc ccttctggga ccacaggtgt     1920

gaactgcgaa gtgaacattg acgactgtgc cagcaacccc tgcacctttg gagtctgccg     1980

tgatggcatc aaccgctacg actgtgtctg ccaacctggc ttcacagggc ccctttgtaa     2040

cgtggagatc aatgagtgtg cttccagccc atgcggcgag ggaggttcct gtgtggatgg     2100

ggaaaatggc ttccgctgcc tctgcccgcc tggctccttg cccccactct gcctcccccc     2160

gagccatccc tgtgcccatg agccctgcag tcacggcatc tgctatgatg cacctggcgg     2220

gttccgctgt gtgtgtgagc ctggctggag tggcccccgc tgcagccaga gcctggcccg     2280

agacgcctgt gagtcccagc cgtgcagggc cggtgggaca tgcagcagcg atggaatggg     2340

tttccactgc acctgcccgc ctggtgtcca gggacgtcag tgtgaactcc tctccccctg     2400

caccccgaac ccctgtgagc atgggggccg ctgcgagtct gcccctggcc agctgcctgt     2460

ctgctcctgc ccccagggct ggcaaggccc acgatgccag caggatgtgg acgagtgtgc     2520

tggccccgca ccctgtggcc ctcatggtat ctgcaccaac ctggcaggga gtttcagctg     2580

cacctgccat ggagggtaca ctggcccttc ctgcgatcag gacatcaatg actgtgaccc     2640

caacccatgc ctgaacggtg gctcgtgcca agacggcgtg ggctcctttt cctgctcctg     2700

cctccctggt ttcgccggcc cacgatgcgc ccgcgatgtg gatgagtgcc tgagcaaccc     2760

ctgcggcccg ggcacctgta ccgaccacgt ggcctccttc acctgcacct gcccgccagg     2820

ctacggaggc ttccactgcg aacaggacct gcccgactgc agccccagct cctgcttcaa     2880

tggcgggacc tgtgtggacg gcgtgaactc gttcagctgc ctgtgccgtc ccggctacac     2940

aggagcccac tgccaacatg aggcagaccc ctgcctctcg cggccctgcc tacacggggg     3000

cgtctgcagc gccgcccacc ctggcttccg ctgcacctgc ctcgagagct tcacgggccc     3060

gcagtgccag acgctggtgg attggtgcag ccgccagcct tgtcaaaacg ggggtcgctg     3120

cgtccagact ggggcctatt gcctttgtcc ccctggatgg agcggacgcc tctgtgacat     3180

ccgaagcttg ccctgcaggg aggccgcagc ccagatcggg gtgcggctgg agcagctgtg     3240

tcaggcgggt gggcagtgtg tggatgaaga cagctcccac tactgcgtgt gcccagaggg     3300

ccgtactggt agccactgtg agcaggaggt ggacccctgc ttggcccagc cctgccagca     3360

tggggggacc tgccgtggct atatgggggg ctacatgtgt gagtgtcttc ctggctacaa     3420

tggtgataac tgtgaggacg acgtggacga gtgtgcctcc cagccctgcc agcacggggg     3480

ttcatgcatt gacctcgtgg cccgctatct ctgctcctgt cccccaggaa cgctgggggt     3540

gctctgcgag attaatgagg atgactgcgg cccaggccca ccgctggact cagggccccg     3600

gtgcctacac aatggcacct gcgtggacct ggtgggtggt ttccgctgca cctgtccccc     3660

aggatacact ggtttgcgct gcgaggcaga catcaatgag tgtcgctcag gtgcctgcca     3720

cgcggcacac acccgggact gcctgcagga cccaggcgga ggtttccgtt gcctttgtca     3780

tgctggcttc tcaggtcctc gctgtcagac tgtcctgtct ccctgcgagt cccagccatg     3840

ccagcatgga ggccagtgcc gtcctagccc gggtcctggg ggtgggctga ccttcacctg     3900

tcactgtgcc cagccgttct ggggtccgcg ttgcgagcgg gtggcgcgct cctgccggga     3960

gctgcagtgc ccggtgggcg tcccatgcca gcagacgccc cgcgggccgc gctgcgcctg     4020

ccccccaggg ttgtcgggac cctcctgccg cagcttcccg gggtcgccgc cgggggccag     4080

caacgccagc tgcgcggccg ccccctgtct ccacgggggc tcctgccgcc ccgcgccgct     4140

cgcgcccttc ttccgctgcg cttgcgcgca gggctggacc gggccgcgct gcgaggcgcc     4200

cgccgcggca cccgaggtct cggaggagcc gcggtgcccg cgcgccgcct gccaggccaa     4260

gcgcggggac cagcgctgcg accgcgagtg caacagccca ggctgcggct gggacggcgg     4320

cgactgctcg ctgagcgtgg gcgacccctg gcggcaatgc gaggcgctgc agtgctggcg     4380

cctcttcaac aacagccgct gcgaccccgc ctgcagctcg cccgcctgcc tctacgacaa     4440

cttcgactgc cacgccggtg gccgcgagcg cacttgcaac ccggtgtacg agaagtactg     4500

cgccgaccac tttgccgacg gccgctgcga ccagggctgc aacacggagg agtgcggctg     4560

ggatgggctg gattgtgcca gcgaggtgcc ggccctgctg gcccgcggcg tgctggtgct     4620

cacagtgctg ctgccgccag aggagctact gcgttccagc gccgactttc tgcagcggct     4680

cagcgccatc ctgcgcacct cgctgcgctt ccgcctggac gcgcacggcc aggccatggt     4740

cttcccttac caccggccta gtcctggctc cgaaccccgg gcccgtcggg agctggcccc     4800

cgaggtgatc ggctcggtag taatgctgga gattgacaac cggctctgcc tgcagtcgcc     4860

tgagaatgat cactgcttcc ccgatgccca gagcgccgct gactacctgg gagcgttgtc     4920

agcggtggag cgcctggact tcccgtaccc actgcgggac gtgcgggggg agccgctgga     4980

gcctccagaa cccagcgtcc cgctgctgcc actgctagtg gcgggcgctg tcttgctgct     5040

ggtcattctc gtcctgggtg tcatggtggc ccggcgcaag cgcgagcaca gcaccctctg     5100

gttccctgag ggcttctcac tgcacaagga cgtggcctct ggtcacaagg gccggcggga     5160

acccgtgggc caggacgcgc tgggcatgaa gaacatggcc aagggtgaga gcctgatggg     5220

ggaggtggcc acagactgga tggacacaga gtgcccagag gccaagcggc taaaggtaga     5280

ggagccaggc atgggggctg aggaggctgt ggattgccgt cagtggactc aacaccatct     5340

ggttgctgct gacatccgcg tggcaccagc catggcactg acaccaccac agggcgacgc     5400

agatgctgat ggcatggatg tcaatgtgcg tggcccagat ggcttcaccc cgctaatgct     5460

ggcttccttc tgtggggggg ctctggagcc aatgccaact gaagaggatg aggcagatga     5520

cacatcagct agcatcatct ccgacctgat ctgccagggg gctcagcttg gggcacggac     5580

tgaccgtact ggcgagactg ctttgcacct ggctgcccgt tatgcccgtg ctgatgcagc     5640

caagcggctg ctggatgctg gggcagacac caatgcccag gaccactcag gccgcactcc     5700

cctgcacaca gctgtcacag ccgatgccca gggtgtcttc cagattctca tccgaaaccg     5760

ctctacagac ttggatgccc gcatggcaga tggctcaacg gcactgatcc tggcggcccg     5820

cctggcagta gagggcatgg tggaagagct catcgccagc catgctgatg tcaatgctgt     5880

ggatgagctt gggaaatcag ccttacactg ggctgcggct gtgaacaacg tggaagccac     5940

tttggccctg ctcaaaaatg gagccaataa ggacatgcag gatagcaagg aggagacccc     6000

cctattcctg gccgcccgcg agggcagcta tgaggctgcc aagctgctgt tggaccactt     6060

tgccaaccgt gagatcaccg accacctgga caggctgccg cgggacgtag cccaggagag     6120

actgcaccag gacatcgtgc gcttgctgga tcaacccagt gggccccgca gcccccccgg     6180

tccccacggc ctggggcctc tgctctgtcc tccaggggcc ttcctccctg gcctcaaagc     6240

ggcacagtcg gggtccaaga agagcaggag gccccccggg aaggcggggc tggggccgca     6300

ggggccccgg gggcggggca agaagctgac gctggcctgc ccgggccccc tggctgacag     6360

ctcggtcacg ctgtcgcccg tggactcgct ggactccccg cggcctttcg gtgggccccc     6420

tgcttcccct ggtggcttcc cccttgaggg gccctatgca gctgccactg ccactgcagt     6480

gtctctggca cagcttggtg gcccaggccg ggcgggtcta gggcgccagc cccctggagg     6540

atgtgtactc agcctgggcc tgctgaaccc tgtggctgtg cccctcgatt gggcccggct     6600

gcccccacct gcccctccag gcccctcgtt cctgctgcca ctggcgccgg gaccccagct     6660

gctcaaccca gggacccccg tctccccgca ggagcggccc ccgccttacc tggcagtccc     6720

aggacatggc gaggagtacc cggcggctgg ggcacacagc agccccccaa aggcccgctt     6780

cctgcgggtt cccagtgagc acccttacct gaccccatcc cccgaatccc ctgagcactg     6840

ggccagcccc tcacctccct ccctctcaga ctggtccgaa tccacgccta gcccagccac     6900

tgccactggg gccatggcca ccaccactgg ggcactgcct gcccagccac ttcccttgtc     6960

tgttcccagc tcccttgctc aggcccagac ccagctgggg ccccagccgg aagttacccc     7020

caagaggcaa gtgttggcct gagacgctcg tcagttctta gatcttgggg gcctaaagag     7080

acccccgtcc tgcctccttt ctttctctgt ctcttccttc cttttagtct ttttcatcct     7140

cttctctttc caccaaccct cctgcatcct tgccttgcag cgtgaccgag ataggtcatc     7200

agcccagggc ttcagtcttc ctttatttat aatgggtggg ggctaccacc caccctctca     7260

gtcttgtgaa gagtctggga cctccttctt ccccacttct ctcttccctc attcctttct     7320

ctctccttct ggcctctcat ttccttacac tctgacatga atgaattatt attattttta     7380

tttttctttt tttttttaca ttttgtatag aaacaaattc atttaaacaa acttattatt     7440

attatttttt acaaaatata tatatggaga tgctccctcc ccctgtgaac cccccagtgc     7500

ccccgtgggg ctgagtctgt gggcccattc ggccaagctg gattctgtgt acctagtaca     7560

caggcatgac tgggatcccg tgtaccgagt acacgaccca ggtatgtacc aagtaggcac     7620

ccttgggcgc acccactggg gccaggggtc gggggagtgt tgggagcctc ctccccaccc     7680

cacctccctc acttcactgc attccagatg ggacatgttc catagccttg ctggggaagg     7740

gcccactgcc aactccctct gccccagccc cacccttggc catctccctt tgggaactag     7800

ggggctgctg gtgggaaatg ggagccaggg cagatgtatg cattcctttg tgtccctgta     7860

aatgtgggac tacaagaaga ggagctgcct gagtggtact ttctcttcct ggtaatcctc     7920

tggcccagcc tcatggcaga atagaggtat ttttaggcta tttttgtaat atggcttctg     7980

gtcaaaatcc ctgtgtagct gaattcccaa gccctgcatt gtacagcccc ccactcccct     8040

caccacctaa taaaggaata gttaacactc aaaaaaaaaa aaaaaaaaa                 8089


<210>  33
<211>  6762
<212>  DNA
<213>  Homo sapiens

<400>  33
agacgtgagg cttgcagcag gccgaggagg aagaagaggg gcagtgggag cagaggaggt       60

ggctcctgcc ccagtgagag ctctgagggt ccctgcctga agagggacag ggaccggggc      120

ttggagaagg ggctgtggaa tgcagccccc ttcactgctg ctgctgctgc tgctgctgct      180

gctgctatgt gtctcagtgg tcagacccag agggctgctg tgtgggagtt tcccagaacc      240

ctgtgccaat ggaggcacct gcctgagcct gtctctggga caagggacct gccagtgtgc      300

ccctggcttc ctgggtgaga cgtgccagtt tcctgacccc tgccagaacg cccagctctg      360

ccaaaatgga ggcagctgcc aagccctgct tcccgctccc ctagggctcc ccagctctcc      420

ctctccattg acacccagct tcttgtgcac ttgcctccct ggcttcactg gtgagagatg      480

ccaggccaag cttgaagacc cttgtcctcc ctccttctgt tccaaaaggg gccgctgcca      540

catccaggcc tcgggccgcc cacagtgctc ctgcatgcct ggatggacag gtgagcagtg      600

ccagcttcgg gacttctgtt cagccaaccc atgtgttaat ggaggggtgt gtctggccac      660

atacccccag atccagtgcc actgcccacc gggcttcgag ggccatgcct gtgaacgtga      720

tgtcaacgag tgcttccagg acccaggacc ctgccccaaa ggcacctcct gccataacac      780

cctgggctcc ttccagtgcc tctgccctgt ggggcaggag ggtccacgtt gtgagctgcg      840

ggcaggaccc tgccctccta ggggctgttc gaatgggggc acctgccagc tgatgccaga      900

gaaagactcc acctttcacc tctgcctctg tcccccaggt ttcataggcc cagactgtga      960

ggtgaatcca gacaactgtg tcagccacca gtgtcagaat gggggcactt gccaggatgg     1020

gctggacacc tacacctgcc tctgcccaga aacctggaca ggctgggact gctccgaaga     1080

tgtggatgag tgtgagaccc agggtccccc tcactgcaga aacgggggca cctgccagaa     1140

ctctgctggt agctttcact gcgtgtgtgt gagtggctgg ggcggcacaa gctgtgagga     1200

gaacctggat gactgtattg ctgccacctg tgccccggga tccacctgca ttgaccgggt     1260

gggctctttc tcctgcctct gcccacctgg acgcacagga ctcctgtgcc acttggaaga     1320

catgtgtctg agccagccgt gccatgggga tgcccaatgc agcaccaacc ccctcacagg     1380

ctccacactc tgcctgtgtc agcctggcta ttcggggccc acctgccacc aggacctgga     1440

cgagtgtctg atggcccagc aaggcccaag tccctgtgaa catggcggtt cctgcctcaa     1500

cactcctggc tccttcaact gcctctgtcc acctggctac acaggctccc gttgtgaggc     1560

tgatcacaat gagtgcctct cccagccctg ccacccagga agcacctgtc tggacctact     1620

tgccaccttc cactgcctct gcccgccagg cttagaaggg cagctctgtg aggtggagac     1680

caacgagtgt gcctcagctc cctgcctgaa ccacgcggat tgccatgacc tgctcaacgg     1740

cttccagtgc atctgcctgc ctggattctc cggcacccga tgtgaggagg atatcgatga     1800

gtgcagaagc tctccctgtg ccaatggtgg gcagtgccag gaccagcctg gagccttcca     1860

ctgcaagtgt ctcccaggct ttgaagggcc acgctgtcaa acagaggtgg atgagtgcct     1920

gagtgaccca tgtcccgttg gagccagctg ccttgatctt ccaggagcct tcttttgcct     1980

ctgcccctct ggtttcacag gccagctctg tgaggttccc ctgtgtgctc ccaacctgtg     2040

ccagcccaag cagatatgta aggaccagaa agacaaggcc aactgcctct gtcctgatgg     2100

aagccctggc tgtgccccac ctgaggacaa ctgcacctgc caccacgggc actgccagag     2160

atcctcatgt gtgtgtgacg tgggttggac ggggccagag tgtgaggcag agctaggggg     2220

ctgcatctct gcaccctgtg cccatggggg gacctgctac ccccagccct ctggctacaa     2280

ctgcacctgc cctacaggct acacaggacc cacctgtagt gaggagatga cagcttgtca     2340

ctcagggcca tgtctcaatg gcggctcctg caaccctagc cctggaggct actactgcac     2400

ctgccctcca agccacacag ggccccagtg ccaaaccagc actgactact gtgtgtctgc     2460

cccgtgcttc aatgggggta cctgtgtgaa caggcctggc accttctcct gcctctgtgc     2520

catgggcttc cagggcccgc gctgtgaggg aaagctccgc cccagctgtg cagacagccc     2580

ctgtaggaat agggcaacct gccaggacag ccctcagggt ccccgctgcc tctgccccac     2640

tggctacacc ggaggcagct gccagactct gatggactta tgtgcccaga agccctgccc     2700

acgcaattcc cactgcctcc agactgggcc ctccttccac tgcttgtgcc tccagggatg     2760

gaccgggcct ctctgcaacc ttccactgtc ctcctgccag aaggctgcac tgagccaagg     2820

catagacgtc tcttcccttt gccacaatgg aggcctctgt gtcgacagcg gcccctccta     2880

tttctgccac tgcccccctg gattccaagg cagcctgtgc caggatcacg tgaacccatg     2940

tgagtccagg ccttgccaga acggggccac ctgcatggcc cagcccagtg ggtatctctg     3000

ccagtgtgcc ccaggctacg atggacagaa ctgctcaaag gaactcgatg cttgtcagtc     3060

ccaaccctgt cacaaccatg gaacctgtac tcccaaacct ggaggattcc actgtgcctg     3120

ccctccaggc tttgtggggc tacgctgtga gggagacgtg gacgagtgtc tggaccagcc     3180

ctgccacccc acaggcactg cagcctgcca ctctctggcc aatgccttct actgccagtg     3240

tctgcctgga cacacaggcc agtggtgtga ggtggagata gacccctgcc acagccaacc     3300

ctgctttcat ggagggacct gtgaggccac agcaggatca cccctgggtt tcatctgcca     3360

ctgccccaag ggttttgaag gccccacctg cagccacagg gccccttcct gcggcttcca     3420

tcactgccac cacggaggcc tgtgtctgcc ctcccctaag ccaggcttcc caccacgctg     3480

tgcctgcctc agtggctatg ggggtcctga ctgcctgacc ccaccagctc ctaaaggctg     3540

tggccctccc tccccatgcc tatacaatgg cagctgctca gagaccacgg gcttgggggg     3600

cccaggcttt cgatgctcct gccctcacag ctctccaggg ccccggtgtc agaaacccgg     3660

agccaagggg tgtgagggca gaagtggaga tggggcctgc gatgctggct gcagtggccc     3720

gggaggaaac tgggatggag gggactgctc tctgggagtc ccagacccct ggaagggctg     3780

cccctcccac tctcggtgct ggcttctctt ccgggacggg cagtgccacc cacagtgtga     3840

ctctgaagag tgtctgtttg atggctacga ctgtgagacc cctccagcct gcactccagc     3900

ctatgaccag tactgccatg atcacttcca caacgggcac tgtgagaaag gctgcaacac     3960

tgcagagtgt ggctgggatg gaggtgactg caggcctgaa gatggggacc cagagtgggg     4020

gccctccctg gccctgctgg tggtactgag ccccccagcc ctagaccagc agctgtttgc     4080

cctggcccgg gtgctgtccc tgactctgag ggtaggactc tgggtaagga aggatcgtga     4140

tggcagggac atggtgtacc cctatcctgg ggcccgggct gaagaaaagc taggaggaac     4200

tcgggacccc acctatcagg agagagcagc ccctcaaacg cagcccctgg gcaaggagac     4260

cgactccctc agtgctgggt ttgtggtggt catgggtgtg gatttgtccc gctgtggccc     4320

tgaccacccg gcatcccgct gtccctggga ccctgggctt ctactccgct tccttgctgc     4380

gatggctgca gtgggagccc tggagcccct gctgcctgga ccactgctgg ctgtccaccc     4440

tcatgcaggg accgcacccc ctgccaacca gcttccctgg cctgtgctgt gctccccagt     4500

ggccggggtg attctcctgg ccctaggggc tcttctcgtc ctccagctca tccggcgtcg     4560

acgccgagag catggagctc tctggctgcc ccctggtttc actcgacggc ctcggactca     4620

gtcagctccc caccgacgcc ggcccccact aggcgaggac agcattggtc tcaaggcact     4680

gaagccaaag gcagaagttg atgaggatgg agttgtgatg tgctcaggcc ctgaggaggg     4740

agaggaggtg ggccaggctg aagaaacagg cccaccctcc acgtgccagc tctggtctct     4800

gagtggtggc tgtggggcgc tccctcaggc agccatgcta actcctcccc aggaatctga     4860

gatggaagcc cctgacctgg acacccgtgg acctgatggg gtgacacccc tgatgtcagc     4920

agtttgctgt ggggaagtac agtccgggac cttccaaggg gcatggttgg gatgtcctga     4980

gccctgggaa cctctgctgg atggaggggc ctgtccccag gctcacaccg tgggcactgg     5040

ggagaccccc ctgcacctgg ctgcccgatt ctcccggcca accgctgccc gccgcctcct     5100

tgaggctgga gccaacccca accagccaga ccgggcaggg cgcacacccc ttcatgctgc     5160

tgtggctgct gatgctcggg aggtctgcca gcttctgctc cgtagcagac aaactgcagt     5220

ggacgctcgc acagaggacg ggaccacacc cttgatgctg gctgccaggc tggcggtgga     5280

agacctggtt gaagaactga ttgcagccca agcagacgtg ggggccagag ataaatgggg     5340

gaaaactgcg ctgcactggg ctgctgccgt gaacaacgcc cgagccgccc gctcgcttct     5400

ccaggccgga gccgataaag atgcccagga caacagggag cagacgccgc tattcctggc     5460

ggcgcgggaa ggagcggtgg aagtagccca gctactgctg gggctggggg cagcccgaga     5520

gctgcgggac caggctgggc tagcgccggc ggacgtcgct caccaacgta accactggga     5580

tctgctgacg ctgctggaag gggctgggcc accagaggcc cgtcacaaag ccacgccggg     5640

ccgcgaggct gggcccttcc cgcgcgcacg gacggtgtca gtaagcgtgc ccccgcatgg     5700

gggcggggct ctgccgcgct gccggacgct gtcagccgga gcaggccctc gtgggggcgg     5760

agcttgtctg caggctcgga cttggtccgt agacttggct gcgcgggggg gcggggccta     5820

ttctcattgc cggagcctct cgggagtagg agcaggagga ggcccgaccc ctcgcggccg     5880

taggttttct gcaggcatgc gcgggcctcg gcccaaccct gcgataatgc gaggaagata     5940

cggagtggct gccgggcgcg gaggcagggt ctcaacggat gactggccct gtgattgggt     6000

ggccctggga gcttgcggtt ctgcctccaa cattccgatc ccgcctcctt gccttactcc     6060

gtccccggag cggggatcac ctcaacttga ctgtggtccc ccagccctcc aagaaatgcc     6120

cataaaccaa ggaggagagg gtaaaaaata gaagaataca tggtagggag gaattccaaa     6180

aatgattacc cattaaaagg caggctggaa ggccttcctg gttttaagat ggatccccca     6240

aaatgaaggg ttgtgagttt agtttctctc ctaaaatgaa tgtatgccca ccagagcaga     6300

catcttccac gtggagaagc tgcagctctg gaaagagggt ttaagatgct aggatgaggc     6360

aggcccagtc ctcctccaga aaataagaca ggccacagga gggcagagtg gagtggaaat     6420

acccctaagt tggaaccaag aattgcaggc atatgggatg taagatgttc tttcctatat     6480

atggtttcca aagggtgccc ctatgatcca ttgtccccac tgcccacaaa tggctgacaa     6540

atatttattg ggcacctact atgtgccagg cactgtgtag gtgctgaaaa gtggccaagg     6600

gccacccccg ctgatgactc cttgcattcc ctcccctcac aacaaagaac tccactgtgg     6660

ggatgaagcg cttcttctag ccactgctat cgctatttaa gaaccctaaa tctgtcaccc     6720

ataataaagc tgatttgaag tgttaaaaaa aaaaaaaaaa aa                        6762


<210>  34
<211>  200
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CMV promoter

<400>  34
atcgatgtta ataattaaca tatatgttaa tcattaacta tatagttaat tattaaccgc       60

tatgttaatg attaacacta gttaggcgtg tacggtggga ggcctatata agcagagctc      120

gtttagtgaa ccgtcagatc gcctggagac gccatccacg ctgttttgac ctccatagaa      180

gacaccggga ccgatccagc                                                  200


<210>  35
<211>  9
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Kozak sequence

<400>  35
gccgccacc                                                                9


