                         SEQUENCE LISTING

<110>  Universitt Heidelberg
 
<120>  RAGE proteins for the treatment of fibrosis

<130>  6024W1008WO

<150>  EP17177679.2
<151>  2017-06-23

<160>  25    

<170>  PatentIn version 3.5

<210>  1
<211>  402
<212>  PRT
<213>  Mus musculus

<400>  1

Met Pro Ala Gly Thr Ala Ala Arg Ala Trp Val Leu Val Leu Ala Leu 
1               5                   10                  15      


Trp Gly Ala Val Ala Gly Gly Gln Asn Ile Thr Ala Arg Ile Gly Glu 
            20                  25                  30          


Pro Leu Val Leu Ser Cys Lys Gly Ala Pro Lys Lys Pro Pro Gln Gln 
        35                  40                  45              


Leu Glu Trp Lys Leu Asn Thr Gly Arg Thr Glu Ala Trp Lys Val Leu 
    50                  55                  60                  


Ser Pro Gln Gly Gly Pro Trp Asp Ser Val Ala Arg Ile Leu Pro Asn 
65                  70                  75                  80  


Gly Ser Leu Leu Leu Pro Ala Thr Gly Ile Val Asp Glu Gly Thr Phe 
                85                  90                  95      


Arg Cys Arg Ala Thr Asn Arg Arg Gly Lys Glu Val Lys Ser Asn Tyr 
            100                 105                 110         


Arg Val Arg Val Tyr Gln Ile Pro Gly Lys Pro Glu Ile Val Asp Pro 
        115                 120                 125             


Ala Ser Glu Leu Thr Ala Ser Val Pro Asn Lys Val Gly Thr Cys Val 
    130                 135                 140                 


Ser Glu Gly Ser Tyr Pro Ala Gly Thr Leu Ser Trp His Leu Asp Gly 
145                 150                 155                 160 


Lys Leu Leu Ile Pro Asp Gly Lys Glu Thr Leu Val Lys Glu Glu Thr 
                165                 170                 175     


Arg Arg His Pro Glu Thr Gly Leu Phe Thr Leu Arg Ser Glu Leu Thr 
            180                 185                 190         


Val Ile Pro Thr Gln Gly Gly Thr His Pro Thr Phe Ser Cys Ser Phe 
        195                 200                 205             


Ser Leu Gly Leu Pro Arg Arg Arg Pro Leu Asn Thr Ala Pro Ile Gln 
    210                 215                 220                 


Leu Arg Val Arg Glu Pro Gly Pro Pro Glu Gly Ile Gln Leu Leu Val 
225                 230                 235                 240 


Glu Pro Glu Gly Gly Ile Val Ala Pro Gly Gly Thr Val Thr Leu Thr 
                245                 250                 255     


Cys Ala Ile Ser Ala Gln Pro Pro Pro Gln Val His Trp Ile Lys Asp 
            260                 265                 270         


Gly Ala Pro Leu Pro Leu Ala Pro Ser Pro Val Leu Leu Leu Pro Glu 
        275                 280                 285             


Val Gly His Glu Asp Glu Gly Thr Tyr Ser Cys Val Ala Thr His Pro 
    290                 295                 300                 


Ser His Gly Pro Gln Glu Ser Pro Pro Val Ser Ile Arg Val Thr Glu 
305                 310                 315                 320 


Thr Gly Asp Glu Gly Pro Ala Glu Gly Ser Val Gly Glu Ser Gly Leu 
                325                 330                 335     


Gly Thr Leu Ala Leu Ala Leu Gly Ile Leu Gly Gly Leu Gly Val Val 
            340                 345                 350         


Ala Leu Leu Val Gly Ala Ile Leu Trp Arg Lys Arg Gln Pro Arg Arg 
        355                 360                 365             


Glu Glu Arg Lys Ala Pro Glu Ser Gln Glu Asp Glu Glu Glu Arg Ala 
    370                 375                 380                 


Glu Leu Asn Gln Ser Glu Glu Ala Glu Met Pro Glu Asn Gly Ala Gly 
385                 390                 395                 400 


Gly Pro 
        


<210>  2
<211>  402
<212>  PRT
<213>  Mus musculus

<400>  2

Met Pro Ala Gly Thr Ala Ala Arg Ala Trp Val Leu Val Leu Ala Leu 
1               5                   10                  15      


Trp Gly Ala Val Ala Gly Gly Gln Asn Ile Thr Ala Arg Ile Gly Glu 
            20                  25                  30          


Pro Leu Val Leu Ser Cys Lys Gly Ala Pro Lys Lys Pro Pro Gln Gln 
        35                  40                  45              


Leu Glu Trp Lys Leu Asn Thr Gly Arg Thr Glu Ala Trp Lys Val Leu 
    50                  55                  60                  


Ser Pro Gln Gly Gly Pro Trp Asp Ser Val Ala Arg Ile Leu Pro Asn 
65                  70                  75                  80  


Gly Ser Leu Leu Leu Pro Ala Thr Gly Ile Val Asp Glu Gly Thr Phe 
                85                  90                  95      


Arg Cys Arg Ala Thr Asn Arg Arg Gly Lys Glu Val Lys Ser Asn Tyr 
            100                 105                 110         


Arg Val Arg Val Tyr Gln Ile Pro Gly Lys Pro Glu Ile Val Asp Pro 
        115                 120                 125             


Ala Ser Glu Leu Thr Ala Ser Val Pro Asn Lys Val Gly Thr Cys Val 
    130                 135                 140                 


Ser Glu Gly Ser Tyr Pro Ala Gly Thr Leu Ser Trp His Leu Asp Gly 
145                 150                 155                 160 


Lys Leu Leu Ile Pro Asp Gly Lys Glu Thr Leu Val Lys Glu Glu Thr 
                165                 170                 175     


Arg Arg His Pro Glu Thr Gly Leu Phe Thr Leu Arg Ser Glu Leu Thr 
            180                 185                 190         


Val Ile Pro Thr Gln Gly Gly Thr His Pro Thr Phe Ser Cys Ser Phe 
        195                 200                 205             


Ser Leu Gly Leu Pro Arg Arg Arg Pro Leu Asn Thr Ala Pro Ile Gln 
    210                 215                 220                 


Leu Arg Val Arg Glu Pro Gly Pro Pro Glu Gly Ile Gln Leu Leu Val 
225                 230                 235                 240 


Glu Pro Glu Gly Gly Ile Val Ala Pro Gly Gly Thr Val Thr Leu Thr 
                245                 250                 255     


Cys Ala Ile Ser Ala Gln Pro Pro Pro Gln Val His Trp Ile Lys Asp 
            260                 265                 270         


Gly Ala Pro Leu Pro Leu Ala Pro Ser Pro Val Leu Leu Leu Pro Glu 
        275                 280                 285             


Val Gly His Glu Asp Glu Gly Thr Tyr Ser Cys Val Ala Thr His Pro 
    290                 295                 300                 


Ser His Gly Pro Gln Glu Ser Pro Pro Val Ser Ile Arg Val Thr Glu 
305                 310                 315                 320 


Thr Gly Asp Glu Gly Pro Ala Glu Gly Ser Val Gly Glu Ser Gly Leu 
                325                 330                 335     


Gly Thr Leu Ala Leu Ala Leu Gly Ile Leu Gly Gly Leu Gly Val Val 
            340                 345                 350         


Ala Leu Leu Val Gly Ala Ile Leu Trp Arg Lys Arg Gln Pro Arg Arg 
        355                 360                 365             


Glu Glu Arg Lys Ala Pro Glu Glu Gln Glu Asp Glu Glu Glu Arg Ala 
    370                 375                 380                 


Glu Leu Asn Gln Glu Glu Glu Ala Glu Met Pro Glu Asn Gly Ala Gly 
385                 390                 395                 400 


Gly Pro 
        


<210>  3
<211>  404
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Ala Ala Gly Thr Ala Val Gly Ala Trp Val Leu Val Leu Ser Leu 
1               5                   10                  15      


Trp Gly Ala Val Val Gly Ala Gln Asn Ile Thr Ala Arg Ile Gly Glu 
            20                  25                  30          


Pro Leu Val Leu Lys Cys Lys Gly Ala Pro Lys Lys Pro Pro Gln Arg 
        35                  40                  45              


Leu Glu Trp Lys Leu Asn Thr Gly Arg Thr Glu Ala Trp Lys Val Leu 
    50                  55                  60                  


Ser Pro Gln Gly Gly Gly Pro Trp Asp Ser Val Ala Arg Val Leu Pro 
65                  70                  75                  80  


Asn Gly Ser Leu Phe Leu Pro Ala Val Gly Ile Gln Asp Glu Gly Ile 
                85                  90                  95      


Phe Arg Cys Gln Ala Met Asn Arg Asn Gly Lys Glu Thr Lys Ser Asn 
            100                 105                 110         


Tyr Arg Val Arg Val Tyr Gln Ile Pro Gly Lys Pro Glu Ile Val Asp 
        115                 120                 125             


Ser Ala Ser Glu Leu Thr Ala Gly Val Pro Asn Lys Val Gly Thr Cys 
    130                 135                 140                 


Val Ser Glu Gly Ser Tyr Pro Ala Gly Thr Leu Ser Trp His Leu Asp 
145                 150                 155                 160 


Gly Lys Pro Leu Val Pro Asn Glu Lys Gly Val Ser Val Lys Glu Gln 
                165                 170                 175     


Thr Arg Arg His Pro Glu Thr Gly Leu Phe Thr Leu Gln Ser Glu Leu 
            180                 185                 190         


Met Val Thr Pro Ala Arg Gly Gly Asp Pro Arg Pro Thr Phe Ser Cys 
        195                 200                 205             


Ser Phe Ser Pro Gly Leu Pro Arg His Arg Ala Leu Arg Thr Ala Pro 
    210                 215                 220                 


Ile Gln Pro Arg Val Trp Glu Pro Val Pro Leu Glu Glu Val Gln Leu 
225                 230                 235                 240 


Val Val Glu Pro Glu Gly Gly Ala Val Ala Pro Gly Gly Thr Val Thr 
                245                 250                 255     


Leu Thr Cys Glu Val Pro Ala Gln Pro Ser Pro Gln Ile His Trp Met 
            260                 265                 270         


Lys Asp Gly Val Pro Leu Pro Leu Pro Pro Ser Pro Val Leu Ile Leu 
        275                 280                 285             


Pro Glu Ile Gly Pro Gln Asp Gln Gly Thr Tyr Ser Cys Val Ala Thr 
    290                 295                 300                 


His Ser Ser His Gly Pro Gln Glu Ser Arg Ala Val Ser Ile Ser Ile 
305                 310                 315                 320 


Ile Glu Pro Gly Glu Glu Gly Pro Thr Ala Gly Ser Val Gly Gly Ser 
                325                 330                 335     


Gly Leu Gly Thr Leu Ala Leu Ala Leu Gly Ile Leu Gly Gly Leu Gly 
            340                 345                 350         


Thr Ala Ala Leu Leu Ile Gly Val Ile Leu Trp Gln Arg Arg Gln Arg 
        355                 360                 365             


Arg Gly Glu Glu Arg Lys Ala Pro Glu Asn Gln Glu Glu Glu Glu Glu 
    370                 375                 380                 


Arg Ala Glu Leu Asn Gln Ser Glu Glu Pro Glu Ala Gly Glu Ser Ser 
385                 390                 395                 400 


Thr Gly Gly Pro 
                


<210>  4
<211>  404
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Ala Ala Gly Thr Ala Val Gly Ala Trp Val Leu Val Leu Ser Leu 
1               5                   10                  15      


Trp Gly Ala Val Val Gly Ala Gln Asn Ile Thr Ala Arg Ile Gly Glu 
            20                  25                  30          


Pro Leu Val Leu Lys Cys Lys Gly Ala Pro Lys Lys Pro Pro Gln Arg 
        35                  40                  45              


Leu Glu Trp Lys Leu Asn Thr Gly Arg Thr Glu Ala Trp Lys Val Leu 
    50                  55                  60                  


Ser Pro Gln Gly Gly Gly Pro Trp Asp Ser Val Ala Arg Val Leu Pro 
65                  70                  75                  80  


Asn Gly Ser Leu Phe Leu Pro Ala Val Gly Ile Gln Asp Glu Gly Ile 
                85                  90                  95      


Phe Arg Cys Gln Ala Met Asn Arg Asn Gly Lys Glu Thr Lys Ser Asn 
            100                 105                 110         


Tyr Arg Val Arg Val Tyr Gln Ile Pro Gly Lys Pro Glu Ile Val Asp 
        115                 120                 125             


Ser Ala Ser Glu Leu Thr Ala Gly Val Pro Asn Lys Val Gly Thr Cys 
    130                 135                 140                 


Val Ser Glu Gly Ser Tyr Pro Ala Gly Thr Leu Ser Trp His Leu Asp 
145                 150                 155                 160 


Gly Lys Pro Leu Val Pro Asn Glu Lys Gly Val Ser Val Lys Glu Gln 
                165                 170                 175     


Thr Arg Arg His Pro Glu Thr Gly Leu Phe Thr Leu Gln Ser Glu Leu 
            180                 185                 190         


Met Val Thr Pro Ala Arg Gly Gly Asp Pro Arg Pro Thr Phe Ser Cys 
        195                 200                 205             


Ser Phe Ser Pro Gly Leu Pro Arg His Arg Ala Leu Arg Thr Ala Pro 
    210                 215                 220                 


Ile Gln Pro Arg Val Trp Glu Pro Val Pro Leu Glu Glu Val Gln Leu 
225                 230                 235                 240 


Val Val Glu Pro Glu Gly Gly Ala Val Ala Pro Gly Gly Thr Val Thr 
                245                 250                 255     


Leu Thr Cys Glu Val Pro Ala Gln Pro Ser Pro Gln Ile His Trp Met 
            260                 265                 270         


Lys Asp Gly Val Pro Leu Pro Leu Pro Pro Ser Pro Val Leu Ile Leu 
        275                 280                 285             


Pro Glu Ile Gly Pro Gln Asp Gln Gly Thr Tyr Ser Cys Val Ala Thr 
    290                 295                 300                 


His Ser Ser His Gly Pro Gln Glu Ser Arg Ala Val Ser Ile Ser Ile 
305                 310                 315                 320 


Ile Glu Pro Gly Glu Glu Gly Pro Thr Ala Gly Ser Val Gly Gly Ser 
                325                 330                 335     


Gly Leu Gly Thr Leu Ala Leu Ala Leu Gly Ile Leu Gly Gly Leu Gly 
            340                 345                 350         


Thr Ala Ala Leu Leu Ile Gly Val Ile Leu Trp Gln Arg Arg Gln Arg 
        355                 360                 365             


Arg Gly Glu Glu Arg Lys Ala Pro Glu Asn Gln Glu Glu Glu Glu Glu 
    370                 375                 380                 


Arg Ala Glu Leu Asn Gln Glu Glu Glu Pro Glu Ala Gly Glu Ser Ser 
385                 390                 395                 400 


Thr Gly Gly Pro 
                


<210>  5
<211>  1209
<212>  DNA
<213>  Mus musculus

<400>  5
atgccagcgg ggacagcagc tagagcctgg gtgctggttc ttgctctatg gggagctgta       60

gctggtggtc agaacatcac agcccggatt ggagagccac ttgtgctaag ctgtaagggg      120

gcccctaaga agccgcccca gcagctagaa tggaaactga acacaggaag aactgaagct      180

tggaaggtcc tctctcccca gggaggcccc tgggacagcg tggctcgaat cctccccaat      240

ggttccctcc tccttccagc cactggaatt gtcgatgagg ggactttccg gtgtcgggca      300

actaacaggc gagggaagga ggtcaagtcc aactaccgag tccgagtcta ccagattcct      360

gggaagccag aaattgtgga tcctgcctct gaactcacag ccagtgtccc taataaggtg      420

gggacatgtg tgtctgaggg aagctaccct gcagggaccc ttagctggca cttagatggg      480

aaacttctga ttcccgatgg caaagaaaca ctcgtgaagg aagagaccag gagacaccct      540

gagacgggac tctttacact gcggtcagag ctgacagtga tccccaccca aggaggaacc      600

catcctacct tctcctgcag tttcagcctg ggccttcccc ggcgcagacc cctgaacaca      660

gcccccatcc aactccgagt cagggagcct gggcctccag agggcattca gctgttggtt      720

gagcctgaag gtggaatagt cgctcctggt gggactgtga ccttgacctg tgccatctct      780

gcccagcccc ctcctcaggt ccactggata aaggatggtg cacccttgcc cctggctccc      840

agccctgtgc tgctcctccc tgaggtgggg cacgaggatg agggcaccta tagctgcgtg      900

gccacccacc ctagccacgg acctcaggaa agccctcctg tcagcatcag ggtcacagaa      960

accggcgatg aggggccagc tgaaggctct gtgggtgagt ctgggctggg tacgctagcc     1020

ctggccttgg ggatcctggg aggcctggga gtagtagccc tgctcgtcgg ggctatcctg     1080

tggcgaaaac gacaacccag gcgtgaggag aggaaggccc cggaagaaca ggaggatgag     1140

gaggaacgtg cagagctgaa tcaggaagag gaagcggaga tgccagagaa tggtgccggg     1200

ggaccgtaa                                                             1209


<210>  6
<211>  1221
<212>  DNA
<213>  Homo sapiens

<400>  6
atggcagccg gaacagcagt tggagcctgg gtgctggtcc tcagtctgtg gggggcagta       60

gtaggtgctc aaaacatcac agcccggatt ggcgagccac tggtgctgaa gtgtaagggg      120

gcccccaaga aaccacccca gcggctggaa tggaaactga acacaggccg gacagaagct      180

tggaaggtcc tgtctcccca gggaggaggc ccctgggaca gtgtggctcg tgtccttccc      240

aacggctccc tcttccttcc ggctgtcggg atccaggatg aggggatttt ccggtgccag      300

gcaatgaaca ggaatggaaa ggagaccaag tccaactacc gagtccgtgt ctaccagatt      360

cctgggaagc cagaaattgt agattctgcc tctgaactca cggctggtgt tcccaataag      420

gtggggacat gtgtgtcaga gggaagctac cctgcaggga ctcttagctg gcacttggat      480

gggaagcccc tggtgcctaa tgagaaggga gtatctgtga aggaacagac caggagacac      540

cctgagacag ggctcttcac actgcagtcg gagctaatgg tgaccccagc ccggggagga      600

gatccccgtc ccaccttctc ctgtagcttc agcccaggcc ttccccgaca ccgggccttg      660

cgcacagccc ccatccagcc ccgtgtctgg gagcctgtgc ctctggagga ggtccaattg      720

gtggtggagc cagaaggtgg agcagtagct cctggtggaa ccgtaaccct gacctgtgaa      780

gtccctgccc agccctctcc tcaaatccac tggatgaagg atggtgtgcc cttgcccctt      840

ccccccagcc ctgtgctgat cctccctgag atagggcctc aggaccaggg aacctacagc      900

tgtgtggcca cccattccag ccacgggccc caggaaagcc gtgctgtcag catcagcatc      960

atcgaaccag gcgaggaggg gccaactgca ggctctgtgg gaggatcagg gctgggaact     1020

ctagccctgg ccctggggat cctgggaggc ctggggacag ccgccctgct cattggggtc     1080

atcttgtggc aaaggcggca acgccgagga gaggagagga aggccccaga aaaccaggag     1140

gaagaggagg agcgtgcaga actgaatcag gaggaggaac ctgaggcagg cgagagtagt     1200

actggagggc ctccgcggat a                                               1221


<210>  7
<211>  7
<212>  PRT
<213>  Simian virus 40

<400>  7

Pro Lys Lys Lys Arg Lys Val 
1               5           


<210>  8
<211>  16
<212>  PRT
<213>  Homo sapiens

<400>  8

Lys Arg Pro Ala Ala Thr Lys Lys Ala Gly Gln Ala Lys Lys Lys Lys 
1               5                   10                  15      


<210>  9
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  9

Pro Ala Ala Lys Arg Val Lys Leu Asp 
1               5                   


<210>  10
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  10

Arg Gln Arg Arg Asn Glu Leu Lys Arg Ser Pro 
1               5                   10      


<210>  11
<211>  38
<212>  PRT
<213>  Homo sapiens

<400>  11

Asn Gln Ser Ser Asn Phe Gly Pro Met Lys Gly Gly Asn Phe Gly Gly 
1               5                   10                  15      


Arg Ser Ser Gly Pro Tyr Gly Gly Gly Gly Gln Tyr Phe Ala Lys Pro 
            20                  25                  30          


Arg Asn Gln Gly Gly Tyr 
        35              


<210>  12
<211>  42
<212>  PRT
<213>  Homo sapiens

<400>  12

Arg Met Arg Ile Glx Phe Lys Asn Lys Gly Lys Asp Thr Ala Glu Leu 
1               5                   10                  15      


Arg Arg Arg Arg Val Glu Val Ser Val Glu Leu Arg Lys Ala Lys Lys 
            20                  25                  30          


Asp Glu Gln Ile Leu Lys Arg Arg Asn Val 
        35                  40          


<210>  13
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  13

Val Ser Arg Lys Arg Pro Arg Pro 
1               5               


<210>  14
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  14

Pro Pro Lys Lys Ala Arg Glu Asp 
1               5               


<210>  15
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  15

Pro Gln Pro Lys Lys Lys Pro Leu 
1               5               


<210>  16
<211>  12
<212>  PRT
<213>  Mus musculus

<400>  16

Ser Ala Leu Ile Lys Lys Lys Lys Lys Met Ala Pro 
1               5                   10          


<210>  17
<211>  5
<212>  PRT
<213>  Influenza virus

<400>  17

Asp Arg Leu Arg Arg 
1               5   


<210>  18
<211>  7
<212>  PRT
<213>  Influenza virus

<400>  18

Pro Lys Gln Lys Lys Arg Lys 
1               5           


<210>  19
<211>  10
<212>  PRT
<213>  Hepatitis D virus

<400>  19

Arg Lys Leu Lys Lys Lys Ile Lys Lys Leu 
1               5                   10  


<210>  20
<211>  10
<212>  PRT
<213>  Mus musculus

<400>  20

Arg Glu Lys Lys Lys Phe Leu Lys Arg Arg 
1               5                   10  


<210>  21
<211>  20
<212>  PRT
<213>  Homo sapiens

<400>  21

Lys Arg Lys Gly Asp Glu Val Asp Gly Val Asp Glu Val Ala Lys Lys 
1               5                   10                  15      


Lys Ser Lys Lys 
            20  


<210>  22
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  22

Arg Lys Cys Leu Gln Ala Gly Met Asn Leu Glu Ala Arg Lys Thr Lys 
1               5                   10                  15      


Lys 
    


<210>  23
<211>  404
<212>  PRT
<213>  Homo sapiens

<400>  23

Met Ala Ala Gly Thr Ala Val Gly Ala Trp Val Leu Val Leu Ser Leu 
1               5                   10                  15      


Trp Gly Ala Val Val Gly Ala Gln Asn Ile Thr Ala Arg Ile Gly Glu 
            20                  25                  30          


Pro Leu Val Leu Lys Cys Lys Gly Ala Pro Lys Lys Pro Pro Gln Arg 
        35                  40                  45              


Leu Glu Trp Lys Leu Asn Thr Gly Arg Thr Glu Ala Trp Lys Val Leu 
    50                  55                  60                  


Ser Pro Gln Gly Gly Gly Pro Trp Asp Ser Val Ala Arg Val Leu Pro 
65                  70                  75                  80  


Asn Gly Ser Leu Phe Leu Pro Ala Val Gly Ile Gln Asp Glu Gly Ile 
                85                  90                  95      


Phe Arg Cys Gln Ala Met Asn Arg Asn Gly Lys Glu Thr Lys Ser Asn 
            100                 105                 110         


Tyr Arg Val Arg Val Tyr Gln Ile Pro Gly Lys Pro Glu Ile Val Asp 
        115                 120                 125             


Ser Ala Ser Glu Leu Thr Ala Gly Val Pro Asn Lys Val Gly Thr Cys 
    130                 135                 140                 


Val Ser Glu Gly Ser Tyr Pro Ala Gly Thr Leu Ser Trp His Leu Asp 
145                 150                 155                 160 


Gly Lys Pro Leu Val Pro Asn Glu Lys Gly Val Ser Val Lys Glu Gln 
                165                 170                 175     


Thr Arg Arg His Pro Glu Thr Gly Leu Phe Thr Leu Gln Ser Glu Leu 
            180                 185                 190         


Met Val Thr Pro Ala Arg Gly Gly Asp Pro Arg Pro Thr Phe Ser Cys 
        195                 200                 205             


Ser Phe Ser Pro Gly Leu Pro Arg His Arg Ala Leu Arg Thr Ala Pro 
    210                 215                 220                 


Ile Gln Pro Arg Val Trp Glu Pro Val Pro Leu Glu Glu Val Gln Leu 
225                 230                 235                 240 


Val Val Glu Pro Glu Gly Gly Ala Val Ala Pro Gly Gly Thr Val Thr 
                245                 250                 255     


Leu Thr Cys Glu Val Pro Ala Gln Pro Ser Pro Gln Ile His Trp Met 
            260                 265                 270         


Lys Asp Gly Val Pro Leu Pro Leu Pro Pro Ser Pro Val Leu Ile Leu 
        275                 280                 285             


Pro Glu Ile Gly Pro Gln Asp Gln Gly Thr Tyr Ser Cys Val Ala Thr 
    290                 295                 300                 


His Ser Ser His Gly Pro Gln Glu Ser Arg Ala Val Ser Ile Ser Ile 
305                 310                 315                 320 


Ile Glu Pro Gly Glu Glu Gly Pro Thr Ala Gly Ser Val Gly Gly Ser 
                325                 330                 335     


Gly Leu Gly Thr Leu Ala Leu Ala Leu Gly Ile Leu Gly Gly Leu Gly 
            340                 345                 350         


Thr Ala Ala Leu Leu Ile Gly Val Ile Lys Trp Gln Arg Arg Gln Arg 
        355                 360                 365             


Arg Gly Glu Glu Arg Lys Ala Pro Glu Asn Gln Glu Glu Glu Glu Glu 
    370                 375                 380                 


Arg Ala Glu Leu Asn Gln Glu Glu Glu Pro Glu Ala Gly Glu Ser Ser 
385                 390                 395                 400 


Thr Gly Gly Pro 
                


<210>  24
<211>  404
<212>  PRT
<213>  Homo sapiens

<400>  24

Met Ala Ala Gly Thr Ala Val Gly Ala Trp Val Leu Val Leu Ser Leu 
1               5                   10                  15      


Trp Gly Ala Val Val Gly Ala Gln Asn Ile Thr Ala Arg Ile Gly Lys 
            20                  25                  30          


Pro Leu Val Leu Lys Cys Lys Gly Ala Pro Lys Lys Pro Pro Gln Arg 
        35                  40                  45              


Leu Glu Trp Lys Leu Asn Thr Gly Arg Thr Glu Ala Trp Lys Val Leu 
    50                  55                  60                  


Ser Pro Gln Gly Gly Gly Pro Trp Asp Ser Val Ala Arg Val Leu Pro 
65                  70                  75                  80  


Asn Gly Ser Leu Phe Leu Pro Ala Val Gly Ile Gln Asp Glu Gly Ile 
                85                  90                  95      


Phe Arg Cys Gln Ala Met Asn Arg Asn Gly Lys Glu Thr Lys Ser Asn 
            100                 105                 110         


Tyr Arg Val Arg Val Tyr Gln Ile Pro Gly Lys Pro Glu Ile Val Asp 
        115                 120                 125             


Ser Ala Ser Glu Leu Thr Ala Gly Val Pro Asn Lys Val Gly Thr Cys 
    130                 135                 140                 


Val Ser Glu Gly Ser Tyr Pro Ala Gly Thr Leu Ser Trp His Leu Asp 
145                 150                 155                 160 


Gly Lys Pro Leu Val Pro Asn Glu Lys Gly Val Ser Val Lys Glu Gln 
                165                 170                 175     


Thr Arg Arg His Pro Glu Thr Gly Leu Phe Thr Leu Gln Ser Glu Leu 
            180                 185                 190         


Met Val Thr Pro Ala Arg Gly Gly Asp Pro Arg Pro Thr Phe Ser Cys 
        195                 200                 205             


Ser Phe Ser Pro Gly Leu Pro Arg His Arg Ala Leu Arg Thr Ala Pro 
    210                 215                 220                 


Ile Gln Pro Arg Val Trp Glu Pro Val Pro Leu Glu Glu Val Gln Leu 
225                 230                 235                 240 


Val Val Glu Pro Glu Gly Gly Ala Val Ala Pro Gly Gly Thr Val Thr 
                245                 250                 255     


Leu Thr Cys Glu Val Pro Ala Gln Pro Ser Pro Gln Ile His Trp Met 
            260                 265                 270         


Lys Asp Gly Val Pro Leu Pro Leu Pro Pro Ser Pro Val Leu Ile Leu 
        275                 280                 285             


Pro Glu Ile Gly Pro Gln Asp Gln Gly Thr Tyr Ser Cys Val Ala Thr 
    290                 295                 300                 


His Ser Ser His Gly Pro Gln Glu Ser Arg Ala Val Ser Ile Ser Ile 
305                 310                 315                 320 


Ile Glu Pro Gly Glu Glu Gly Pro Thr Ala Gly Ser Val Gly Gly Ser 
                325                 330                 335     


Gly Leu Gly Thr Leu Ala Leu Ala Leu Gly Ile Leu Gly Gly Leu Gly 
            340                 345                 350         


Thr Ala Ala Leu Leu Ile Gly Val Ile Leu Trp Gln Arg Arg Gln Arg 
        355                 360                 365             


Arg Gly Glu Glu Arg Lys Ala Pro Glu Asn Gln Glu Glu Glu Glu Glu 
    370                 375                 380                 


Arg Ala Glu Leu Asn Gln Glu Glu Glu Pro Glu Ala Gly Glu Ser Ser 
385                 390                 395                 400 


Thr Gly Gly Pro 
                


<210>  25
<211>  404
<212>  PRT
<213>  Homo sapiens

<400>  25

Met Ala Ala Gly Thr Ala Val Gly Ala Trp Val Leu Val Leu Ser Leu 
1               5                   10                  15      


Trp Gly Ala Val Val Gly Ala Gln Asn Ile Thr Ala Arg Ile Gly Glu 
            20                  25                  30          


Pro Leu Val Leu Lys Cys Lys Gly Ala Pro Lys Lys Pro Pro Gln Arg 
        35                  40                  45              


Leu Glu Trp Lys Leu Asn Thr Gly Arg Thr Glu Ala Trp Lys Val Leu 
    50                  55                  60                  


Ser Pro Gln Gly Gly Gly Pro Trp Asp Ser Val Ala Arg Val Leu Pro 
65                  70                  75                  80  


Asn Gly Ser Leu Phe Leu Pro Ala Val Gly Ile Gln Asp Glu Gly Ile 
                85                  90                  95      


Phe Arg Cys Gln Ala Met Asn Arg Asn Gly Lys Glu Thr Lys Ser Asn 
            100                 105                 110         


Tyr Arg Val Arg Val Tyr Gln Ile Pro Gly Lys Pro Glu Ile Val Asp 
        115                 120                 125             


Ser Ala Ser Glu Leu Thr Ala Gly Val Pro Asn Lys Val Gly Thr Cys 
    130                 135                 140                 


Val Ser Glu Gly Ser Tyr Pro Ala Gly Thr Leu Ser Trp His Leu Asp 
145                 150                 155                 160 


Gly Lys Pro Leu Val Pro Asn Glu Lys Gly Val Ser Val Lys Glu Gln 
                165                 170                 175     


Thr Arg Arg His Pro Glu Thr Gly Leu Phe Thr Leu Gln Ser Glu Leu 
            180                 185                 190         


Met Val Thr Pro Ala Arg Gly Gly Asp Pro Arg Pro Thr Phe Ser Cys 
        195                 200                 205             


Ser Phe Ser Pro Gly Leu Pro Arg His Arg Ala Leu Arg Thr Ala Pro 
    210                 215                 220                 


Ile Gln Pro Arg Val Trp Glu Pro Val Pro Leu Glu Glu Val Gln Leu 
225                 230                 235                 240 


Val Val Glu Pro Glu Gly Gly Ala Val Ala Pro Gly Gly Thr Val Thr 
                245                 250                 255     


Leu Thr Cys Glu Val Pro Ala Gln Pro Ser Pro Gln Ile His Trp Met 
            260                 265                 270         


Lys Asp Gly Val Pro Leu Pro Leu Pro Pro Ser Pro Val Leu Ile Leu 
        275                 280                 285             


Pro Glu Ile Gly Pro Gln Asp Gln Gly Thr Tyr Ser Cys Val Ala Thr 
    290                 295                 300                 


His Ser Ser His Gly Pro Gln Glu Ser Arg Ala Val Ser Ile Ser Ile 
305                 310                 315                 320 


Ile Glu Pro Gly Glu Glu Gly Pro Thr Ala Gly Ser Val Gly Gly Ser 
                325                 330                 335     


Gly Leu Gly Thr Leu Ala Leu Ala Leu Gly Ile Leu Gly Gly Leu Gly 
            340                 345                 350         


Thr Ala Ala Leu Leu Ile Gly Val Ile Leu Trp Gln Arg Arg Lys Arg 
        355                 360                 365             


Arg Gly Glu Glu Arg Lys Ala Pro Glu Asn Gln Glu Glu Glu Glu Glu 
    370                 375                 380                 


Arg Ala Glu Leu Asn Gln Glu Glu Glu Pro Glu Ala Gly Glu Ser Ser 
385                 390                 395                 400 


Thr Gly Gly Pro 
                


