                         SEQUENCE LISTING

<110>  Swedish Orphan Biovitrum AB (publ)
 
<120>  FUSION PROTEIN WITH HALF-LIFE EXTENDING POLYPEPTIDE

<130>  21090107

<160>  105   

<170>  PatentIn version 3.5

<210>  1
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Generic repeating sequence derived from human BSSL CTD


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (8)..(11)
<223>  Xaa can be any naturally occurring amino acid

<400>  1

Xaa Xaa Xaa Xaa Xaa Xaa Asp Xaa Xaa Xaa Xaa 
1               5                   10      


<210>  2
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  2

Pro Thr Val Thr Asp Gln Glu Ala Thr 
1               5                   


<210>  3
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  3

Pro Val Pro Pro Thr Gly Asp Ser Glu Ala Thr 
1               5                   10      


<210>  4
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  4

Pro Val Pro Pro Thr Gly Asp Ser Glu Thr Ala 
1               5                   10      


<210>  5
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  5

Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro 
1               5                   10      


<210>  6
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  6

Pro Val Pro Pro Thr Gly Asp Ala Gly Pro Pro 
1               5                   10      


<210>  7
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  7

Pro Val Thr Pro Thr Gly Asp Ser Glu Thr Ala 
1               5                   10      


<210>  8
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  8

Pro Val Pro Pro Thr Gly Asp Ser Glu Ala Ala 
1               5                   10      


<210>  9
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  9

Pro Val Pro Pro Thr Asp Asp Ser Lys Glu Ala 
1               5                   10      


<210>  10
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  10

Pro Val Pro Pro Thr Gly Asp Ser Gly Pro Pro 
1               5                   10      


<210>  11
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  11

Pro Val Pro Pro Thr Gly Asp Ser Lys Glu Ala 
1               5                   10      


<210>  12
<211>  196
<212>  PRT
<213>  Homo sapiens

<400>  12

Pro Thr Val Thr Asp Gln Glu Ala Thr Pro Val Pro Pro Thr Gly Asp 
1               5                   10                  15      


Ser Glu Ala Thr Pro Val Pro Pro Thr Gly Asp Ser Glu Thr Ala Pro 
            20                  25                  30          


Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly 
        35                  40                  45              


Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro 
    50                  55                  60                  


Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr 
65                  70                  75                  80  


Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala 
                85                  90                  95      


Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro 
            100                 105                 110         


Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ala Gly 
        115                 120                 125             


Pro Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro 
    130                 135                 140                 


Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Thr Pro Thr Gly Asp Ser 
145                 150                 155                 160 


Glu Thr Ala Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val 
                165                 170                 175     


Pro Pro Thr Gly Asp Ser Glu Ala Ala Pro Val Pro Pro Thr Asp Asp 
            180                 185                 190         


Ser Lys Glu Ala 
        195     


<210>  13
<211>  196
<212>  PRT
<213>  Homo sapiens

<400>  13

Pro Thr Val Thr Asp Gln Glu Ala Thr Pro Val Pro Pro Thr Gly Asp 
1               5                   10                  15      


Ser Glu Ala Thr Pro Val Pro Pro Thr Gly Asp Ser Glu Thr Ala Pro 
            20                  25                  30          


Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly 
        35                  40                  45              


Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro 
    50                  55                  60                  


Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr 
65                  70                  75                  80  


Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala 
                85                  90                  95      


Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro 
            100                 105                 110         


Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ala Gly 
        115                 120                 125             


Pro Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro 
    130                 135                 140                 


Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Thr Pro Thr Gly Asp Ser 
145                 150                 155                 160 


Glu Thr Ala Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val 
                165                 170                 175     


Pro Pro Thr Gly Asp Ser Glu Ala Ala Pro Val Pro Pro Thr Asp Asp 
            180                 185                 190         


Ser Lys Glu Ala 
        195     


<210>  14
<211>  185
<212>  PRT
<213>  Homo sapiens

<400>  14

Pro Thr Val Thr Asp Gln Glu Ala Thr Pro Val Pro Pro Thr Gly Asp 
1               5                   10                  15      


Ser Glu Ala Thr Pro Val Pro Pro Thr Gly Asp Ser Glu Thr Ala Pro 
            20                  25                  30          


Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly 
        35                  40                  45              


Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro 
    50                  55                  60                  


Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr 
65                  70                  75                  80  


Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala 
                85                  90                  95      


Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro 
            100                 105                 110         


Thr Gly Asp Ala Gly Pro Pro Pro Val Pro Pro Thr Gly Asp Ser Gly 
        115                 120                 125             


Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Thr 
    130                 135                 140                 


Pro Thr Gly Asp Ser Glu Thr Ala Pro Val Pro Pro Thr Gly Asp Ser 
145                 150                 155                 160 


Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Glu Ala Ala Pro Val 
                165                 170                 175     


Pro Pro Thr Asp Asp Ser Lys Glu Ala 
            180                 185 


<210>  15
<211>  185
<212>  PRT
<213>  Homo sapiens

<400>  15

Pro Thr Val Thr Asp Gln Glu Ala Thr Pro Val Pro Pro Thr Gly Asp 
1               5                   10                  15      


Ser Glu Ala Thr Pro Val Pro Pro Thr Gly Asp Ser Glu Thr Ala Pro 
            20                  25                  30          


Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly 
        35                  40                  45              


Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro 
    50                  55                  60                  


Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr 
65                  70                  75                  80  


Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala 
                85                  90                  95      


Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro 
            100                 105                 110         


Thr Gly Asp Ala Gly Pro Pro Pro Val Pro Pro Thr Gly Asp Ser Gly 
        115                 120                 125             


Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Thr 
    130                 135                 140                 


Pro Thr Gly Asp Ser Glu Thr Ala Pro Val Pro Pro Thr Gly Asp Ser 
145                 150                 155                 160 


Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Glu Ala Ala Pro Val 
                165                 170                 175     


Pro Pro Thr Asp Asp Ser Lys Glu Ala 
            180                 185 


<210>  16
<211>  163
<212>  PRT
<213>  Homo sapiens

<400>  16

Pro Thr Val Thr Asp Gln Glu Ala Thr Pro Val Pro Pro Thr Gly Asp 
1               5                   10                  15      


Ser Glu Ala Thr Pro Val Pro Pro Thr Gly Asp Ser Glu Thr Ala Pro 
            20                  25                  30          


Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly 
        35                  40                  45              


Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro 
    50                  55                  60                  


Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr 
65                  70                  75                  80  


Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala 
                85                  90                  95      


Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro 
            100                 105                 110         


Thr Gly Asp Ala Gly Pro Pro Pro Val Pro Pro Thr Gly Asp Ser Gly 
        115                 120                 125             


Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Thr 
    130                 135                 140                 


Pro Thr Gly Asp Ser Glu Thr Ala Pro Val Pro Pro Thr Gly Asp Ser 
145                 150                 155                 160 


Gly Ala Pro 
            


<210>  17
<211>  75
<212>  PRT
<213>  Homo sapiens

<400>  17

Pro Thr Val Thr Asp Gln Glu Ala Thr Pro Val Pro Pro Thr Gly Asp 
1               5                   10                  15      


Ser Glu Ala Thr Pro Val Pro Pro Thr Gly Asp Ser Glu Thr Ala Pro 
            20                  25                  30          


Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly 
        35                  40                  45              


Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Glu Ala Ala 
    50                  55                  60                  


Pro Val Pro Pro Thr Gly Asp Ser Lys Glu Ala 
65                  70                  75  


<210>  18
<211>  163
<212>  PRT
<213>  Homo sapiens

<400>  18

Pro Thr Val Thr Asp Gln Glu Ala Thr Pro Val Pro Pro Thr Gly Asp 
1               5                   10                  15      


Ser Glu Ala Thr Pro Val Pro Pro Thr Gly Asp Ser Glu Thr Ala Pro 
            20                  25                  30          


Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly 
        35                  40                  45              


Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro 
    50                  55                  60                  


Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr 
65                  70                  75                  80  


Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ala Gly Pro 
                85                  90                  95      


Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro 
            100                 105                 110         


Thr Gly Asp Ser Gly Ala Pro Pro Val Thr Pro Thr Gly Asp Ser Glu 
        115                 120                 125             


Thr Ala Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro 
    130                 135                 140                 


Pro Thr Gly Asp Ser Glu Ala Ala Pro Val Pro Pro Thr Asp Asp Ser 
145                 150                 155                 160 


Lys Glu Ala 
            


<210>  19
<211>  185
<212>  PRT
<213>  Homo sapiens

<400>  19

Pro Thr Val Thr Asp Gln Glu Ala Thr Pro Val Pro Pro Thr Gly Asp 
1               5                   10                  15      


Ser Glu Ala Thr Pro Val Pro Pro Thr Gly Asp Ser Glu Thr Ala Pro 
            20                  25                  30          


Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly 
        35                  40                  45              


Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro 
    50                  55                  60                  


Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr 
65                  70                  75                  80  


Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala 
                85                  90                  95      


Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro 
            100                 105                 110         


Thr Gly Asp Ala Gly Pro Pro Pro Val Pro Pro Thr Gly Asp Ser Gly 
        115                 120                 125             


Pro Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Thr 
    130                 135                 140                 


Pro Thr Gly Asp Ser Glu Thr Ala Pro Val Pro Pro Thr Gly Asp Ser 
145                 150                 155                 160 


Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Glu Ala Ala Pro Val 
                165                 170                 175     


Pro Pro Thr Asp Asp Ser Lys Glu Ala 
            180                 185 


<210>  20
<211>  119
<212>  PRT
<213>  Homo sapiens

<400>  20

Pro Thr Val Thr Asp Gln Glu Ala Thr Pro Val Pro Pro Thr Gly Asp 
1               5                   10                  15      


Ser Glu Ala Thr Pro Val Pro Pro Thr Gly Asp Ser Glu Thr Ala Pro 
            20                  25                  30          


Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly 
        35                  40                  45              


Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro 
    50                  55                  60                  


Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr 
65                  70                  75                  80  


Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala 
                85                  90                  95      


Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro 
            100                 105                 110         


Thr Asp Asp Ser Lys Glu Ala 
        115                 


<210>  21
<211>  86
<212>  PRT
<213>  Homo sapiens

<400>  21

Pro Thr Val Thr Asp Gln Glu Ala Thr Pro Val Pro Pro Thr Gly Asp 
1               5                   10                  15      


Ser Glu Ala Thr Pro Val Pro Pro Thr Gly Asp Ser Glu Thr Ala Pro 
            20                  25                  30          


Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly 
        35                  40                  45              


Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro 
    50                  55                  60                  


Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr 
65                  70                  75                  80  


Gly Asp Ser Gly Ala Pro 
                85      


<210>  22
<211>  1137
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IL1RA-G4SG4SG4S-BSSL CTD (17)

<400>  22
atggaaatct gcagaggcct ccgcagtcac ctaatcactc tcctcctctt cctgttccat       60

tcagagacga tctgccgacc ctctgggaga aaatccagca agatgcaagc cttcagaatc      120

tgggatgtta accagaagac cttctatctg aggaacaacc aactagttgc tggatacttg      180

caaggaccaa atgtcaattt agaagaaaag atagatgtgg tacccattga gcctcatgct      240

ctgttcttgg gaatccatgg agggaagatg tgcctgtcct gtgtcaagtc tggtgatgag      300

accagactcc agctggaggc agttaacatc actgacctga gcgagaacag aaagcaggac      360

aagcgcttcg ccttcatccg ctcagacagt ggccccacca ccagttttga gtctgccgcc      420

tgccccggtt ggttcctctg cacagcgatg gaagctgacc agcccgtcag cctcaccaat      480

atgcctgacg aaggcgtcat ggtcaccaaa ttctacttcc aggaggacga gggcggcgga      540

ggaagtggag gcggaggatc tggcggaggc ggatctccgg ttccgcctac cggtgatagc      600

gaagcaacac cggtgcctcc gaccggtgat tcagaaaccg caccggttcc accgacaggc      660

gatagcggtg cacctcctgt tcctccaaca ggtgattctg gtgcccctcc ggtgccacca      720

actggcgatt caggtgctcc gccagttccg ccaacgggtg acagtggtgc cccaccagta      780

ccgcctacag gggatagtgg cgcaccgcca gtgccaccta caggtgactc aggcgcacca      840

cctgtaccac cgactgggga ctcgggtgcg cctccagtac ctccgactgg tgacagcgga      900

gcgccacctg tcccaccaac cggtgatgca ggtccaccgc ctgtccctcc gacgggtgat      960

agtggtgctc cgcctgttcc accgactggt gattccggtg caccaccggt tacgccgact     1020

ggcgacagtg aaacagctcc tgtgcctcct actggcgata gcggagcccc tccagtccca     1080

cctacgggtg attctgaagc agctccagtt ccaccaactg atgatagcaa agaagca        1137


<210>  23
<211>  1599
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IL1RA-G4SG4SG4S-BSSL CTD (17)-GS-IL1RA

<400>  23
atggaaatct gcagaggcct ccgcagtcac ctaatcactc tcctcctctt cctgttccat       60

tcagagacga tctgccgacc ctctgggaga aaatccagca agatgcaagc cttcagaatc      120

tgggatgtta accagaagac cttctatctg aggaacaacc aactagttgc tggatacttg      180

caaggaccaa atgtcaattt agaagaaaag atagatgtgg tacccattga gcctcatgct      240

ctgttcttgg gaatccatgg agggaagatg tgcctgtcct gtgtcaagtc tggtgatgag      300

accagactcc agctggaggc agttaacatc actgacctga gcgagaacag aaagcaggac      360

aagcgcttcg ccttcatccg ctcagacagt ggccccacca ccagttttga gtctgccgcc      420

tgccccggtt ggttcctctg cacagcgatg gaagctgacc agcccgtcag cctcaccaat      480

atgcctgacg aaggcgtcat ggtcaccaaa ttctacttcc aggaggacga gggcggcgga      540

ggaagtggag gcggaggatc tggcggaggc ggatctccgg ttccgcctac cggtgatagc      600

gaagcaacac cggtgcctcc gaccggtgat tcagaaaccg caccggttcc accgacaggc      660

gatagcggtg cacctcctgt tcctccaaca ggtgattctg gtgcccctcc ggtgccacca      720

actggcgatt caggtgctcc gccagttccg ccaacgggtg acagtggtgc cccaccagta      780

ccgcctacag gggatagtgg cgcaccgcca gtgccaccta caggtgactc aggcgcacca      840

cctgtaccac cgactgggga ctcgggtgcg cctccagtac ctccgactgg tgacagcgga      900

gcgccacctg tcccaccaac cggtgatgca ggtccaccgc ctgtccctcc gacgggtgat      960

agtggtgctc cgcctgttcc accgactggt gattccggtg caccaccggt tacgccgact     1020

ggcgacagtg aaacagctcc tgtgcctcct actggcgata gcggagcccc tccagtccca     1080

cctacgggtg attctgaagc agctccagtt ccaccaactg atgatagcaa agaagcagga     1140

tccagaccca gcggccggaa gtccagcaag atgcaggcct tccggatctg ggacgtgaac     1200

cagaaaacct tctacctccg gaacaaccag ctcgtggccg gctatctgca gggccccaac     1260

gtgaacctgg aagagaagat cgacgtggtg cccatcgagc cccacgccct gtttctgggc     1320

atccacggcg gcaagatgtg cctgagctgc gtgaagtccg gcgacgagac aagactgcag     1380

ctggaagccg tgaacatcac cgatctgtcc gagaaccgga agcaggacaa gcggttcgcc     1440

ttcatcagaa gcgacagcgg ccccaccaca agctttgaga gcgccgcctg ccccggctgg     1500

tttctgtgta ccgccatgga agccgaccag cccgtgtccc tgaccaacat gcccgacgag     1560

ggcgtgatgg tcaccaagtt ctactttcaa gaagatgag                            1599


<210>  24
<211>  1705
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IL1RA-G4SG4SG4S-BSSL CTD (34, v1)-GS

<400>  24
atggaaatct gcagaggcct ccgcagtcac ctaatcactc tcctcctctt cctgttccat       60

tcagagacga tctgccgacc ctctgggaga aaatccagca agatgcaagc cttcagaatc      120

tgggatgtta accagaagac cttctatctg aggaacaacc aactagttgc tggatacttg      180

caaggaccaa atgtcaattt agaagaaaag atagatgtgg tacccattga gcctcatgct      240

ctgttcttgg gaatccatgg agggaagatg tgcctgtcct gtgtcaagtc tggtgatgag      300

accagactcc agctggaggc agttaacatc actgacctga gcgagaacag aaagcaggac      360

aagcgcttcg ccttcatccg ctcagacagt ggccccacca ccagttttga gtctgccgcc      420

tgccccggtt ggttcctctg cacagcgatg gaagctgacc agcccgtcag cctcaccaat      480

atgcctgacg aaggcgtcat ggtcaccaaa ttctacttcc aggaggacga gggcggcgga      540

ggaagtggag gcggaggatc tggcggaggc ggatctcccg tgccccccac cggcgattct      600

gaagctacac ctgtgcctcc aaccggcgac agcgaaacag ctcctgtgcc acctactggc      660

gactctggcg ctcctccagt gccaccaaca ggggatagcg gagcaccccc agtgcctccc      720

actggggatt caggcgcacc accagtgccc cctaccgggg acagtggcgc acctcccgtg      780

cctccaactg gcgatagtgg cgctccccct gtgcctccta ccggggatag cggggctcct      840

cctgtgccac ccaccgggga ttctggggca ccccccgtgc caccaaccgg ggactccggc      900

gctccacctg tgcccccaac tggcgattca ggggcacctc ctgtgccccc aaccggcgat      960

agcggagccc cacccgtgcc accaacaggc gattctggcg ccccacctgt gccacctact     1020

ggggacagcg gagccccacc tgtgccccct accggcgact ccggggcacc accagtgcct     1080

ccaacagggg actctggggc ccctccagtg cctcctaccg gcgattcagg ggctccccca     1140

gtgccaccta ctggcgatag tggggcacca cccgtgcccc ctactggcga cagcggcgct     1200

ccccccgtgc cacccaccgg cgacagcgga gcacctccag tgccaccaac cggcgattcc     1260

ggcgcacctc cagtgccccc cactggcgac tctggggctc cccctgtgcc ccccactggg     1320

gacagtgggg caccacctgt gccaccaact ggggatagtg gcgcccctcc agtgccccca     1380

actggggatt ctggcgctcc tcccgtgcct cctactgggg actcaggggc accccccgtg     1440

cctcccaccg gcgatagtgg ggcccctccc gtgcctccaa ccggggatgc tggaccacca     1500

ccagtgccac ccactggcga tagcggcgct ccaccagtgc ctccaaccgg cgatagcggg     1560

gcaccacctg tgactcctac cggcgatagt gaaaccgccc ctgtgcctcc aactggcgac     1620

tccggcgcac cacccgtgcc acctaccggc gattcagagg cagctcccgt gcctcccaca     1680

gacgactcta aagaggccgg atcct                                           1705


<210>  25
<211>  1704
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IL1RA-G4SG4SG4S-BSSL CTD (34, v2)-GS

<400>  25
atggaaatct gcagaggcct ccgcagtcac ctaatcactc tcctcctctt cctgttccat       60

tcagagacga tctgccgacc ctctgggaga aaatccagca agatgcaagc cttcagaatc      120

tgggatgtta accagaagac cttctatctg aggaacaacc aactagttgc tggatacttg      180

caaggaccaa atgtcaattt agaagaaaag atagatgtgg tacccattga gcctcatgct      240

ctgttcttgg gaatccatgg agggaagatg tgcctgtcct gtgtcaagtc tggtgatgag      300

accagactcc agctggaggc agttaacatc actgacctga gcgagaacag aaagcaggac      360

aagcgcttcg ccttcatccg ctcagacagt ggccccacca ccagttttga gtctgccgcc      420

tgccccggtt ggttcctctg cacagcgatg gaagctgacc agcccgtcag cctcaccaat      480

atgcctgacg aaggcgtcat ggtcaccaaa ttctacttcc aggaggacga gggcggcgga      540

ggaagtggag gcggaggatc tggcggaggc ggatctcccg tgccccccac cggcgattct      600

gaagctacac ctgtgcctcc aaccggcgac agcgaaacag ctcctgtgcc acctactggc      660

gactctggcg ctcctccagt gccaccaaca ggggatagcg gagcaccccc agtgcctccc      720

actggggatt caggcgcacc accagtgccc cctaccgggg acagtggcgc acctcccgtg      780

cctccaactg gcgatagtgg cgctccccct gtgcctccta ccggggatag cggggctcct      840

cctgtgccac ccaccgggga ttctggggca ccccccgtgc caccaaccgg ggactccggc      900

gctccacctg tgccccccac tggcgacgca ggacctccac cagtgcctcc aacaggcgat      960

tctggggcac ctcctgtgcc ccctactggc gatagcggag caccacctgt gacacctacc     1020

ggcgattccg agacagcccc agtgccacca actggcgaca gtggggcacc accagtgcca     1080

cccactggcg atagtgaagc cgctccagtg ccccccacag acgactctaa agaggcccct     1140

gtgcccccaa ctggggactc tgaagcaact ccagtgccac ctaccggcga cagcgagact     1200

gcacccgtgc ctccaaccgg ggattcaggg gctcccccag tgcctcctac tggcgactcc     1260

ggggcaccac ccgtgccccc aactggggat tctggcgccc ctcctgtgcc tcccaccggc     1320

gactcaggcg cccctcccgt gccacctact ggggatagtg gggcccctcc agtgccccca     1380

accggcgatt ccggcgcacc tccagtgcct ccaaccgggg actctggggc acctccagtg     1440

cctccaacag gcgacagcgg agcccctcct gtgccaccaa caggcgacgc tggaccaccc     1500

cccgtgccac ctactggcga cagcggcgca cctcctgtgc cccccactgg ggattccggc     1560

gctccccccg tgactccaac aggcgactct gaaacagccc cagtgcctcc caccggcgat     1620

agcggcgcac cacccgtgcc accaacaggc gattccgaag ctgctcccgt gcctcctacc     1680

gacgatagca aagaggccgg atcc                                            1704


<210>  26
<211>  1617
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  M-IL1RA-G4SG4S-BSSL CTD (34, v1)-GS

<400>  26
atgcgtccga gcggtcgtaa aagcagcaaa atgcaggcat ttcgtatttg ggatgtgaac       60

cagaaaacct tttatctgcg taacaatcag ctggttgcag gttatctgca gggtccgaat      120

gttaatctgg aagaaaaaat tgatgtggtg ccgattgaac cgcatgcact gtttctgggt      180

attcatggtg gtaaaatgtg tctgagctgt gttaaaagcg gtgatgaaac ccgtctgcag      240

ctggaagcag tgaatatcac cgatctgagc gaaaatcgta aacaggataa acgctttgcc      300

tttattcgta gcgatagcgg tccgaccacc agttttgaaa gcgcagcatg tccgggttgg      360

tttctgtgta ccgcaatgga agcagatcag ccggttagcc tgaccaatat gccggatgaa      420

ggtgttatgg ttaccaaatt ctatttccaa gaggatgaag gcggtggtgg ttcaggtggt      480

ggtggatctc cggttccgcc taccggtgat agcgaagcaa caccggtgcc tccgaccggt      540

gattcagaaa ccgcaccggt tccaccgaca ggcgatagcg gtgcacctcc tgttcctcca      600

acaggtgatt ctggtgcccc tccggtgcca ccaactggcg attcaggtgc tccgccagtt      660

ccgccaacgg gtgacagtgg tgccccacca gtaccgccta caggggatag tggcgcaccg      720

ccagtgccac ctacaggtga ctcaggcgca ccacctgtac caccgactgg ggactcgggt      780

gcgcctccag tacctccgac tggtgacagc ggagcgccac ctgtcccacc tacgggtgat      840

tccggtgctc caccggtccc accgactggt gattctggcg caccgcctgt ccctccgaca      900

ggcgacagtg gcgcaccacc ggttccacca accggtgact caggtgcgcc tccggttcct      960

cctacaggcg attcaggggc acctccagtc ccaccaacag gggatagcgg agccccacca     1020

gttcctccga ctggggattc aggtgcccca cctgttccac cgaccggtga tagtggtgct     1080

ccacctgtgc ctccgactgg cgatagcgga gcccctccgg ttccacctac aggtgacagt     1140

ggtgcccctc cggttcctcc gacgggtgac tccggtgcac ctccagttcc acctactggc     1200

gatagtggcg cacctcctgt accgcctact ggcgacagcg gtgctccgcc tgtaccacct     1260

accggtgact ctggtgcccc accagtccct ccaacgggtg atagcggtgc tcctccagtc     1320

cctcctaccg gtgattcggg tgcacctcct gtgccaccta cgggtgacag cggtgcacca     1380

cctgtgccac caactggtga tgccggtccg ccacctgtac cgccaaccgg tgatagcgga     1440

gcgcctcctg taccgccaac aggggattca ggcgctcctc ctgtgacgcc gacaggtgat     1500

tccgagacag cccctgttcc gccaacaggc gactcgggtg caccaccggt tccgcctacg     1560

ggtgattcag aagcagctcc ggttccgcca actgatgata gtaaagaagc aggatcc        1617


<210>  27
<211>  1617
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  M- IL1RA-G4SG4S-BSSL CTD (34, v2)-GS

<400>  27
atgcgtccga gcggtcgtaa aagcagcaaa atgcaggcat ttcgtatttg ggatgtgaac       60

cagaaaacct tttatctgcg taacaatcag ctggttgcag gttatctgca gggtccgaat      120

gttaatctgg aagaaaaaat tgatgtggtg ccgattgaac cgcatgcact gtttctgggt      180

attcatggtg gtaaaatgtg tctgagctgt gttaaaagcg gtgatgaaac ccgtctgcag      240

ctggaagcag tgaatatcac cgatctgagc gaaaatcgta aacaggataa acgctttgcc      300

tttattcgta gcgatagcgg tccgaccacc agttttgaaa gcgcagcatg tccgggttgg      360

tttctgtgta ccgcaatgga agcagatcag ccggttagcc tgaccaatat gccggatgaa      420

ggtgttatgg ttaccaaatt ctatttccaa gaggatgaag gcggtggtgg ttcaggtggt      480

ggtggatctc cggttccgcc taccggtgat agcgaagcaa caccggtgcc tccgaccggt      540

gattcagaaa ccgcaccggt tccaccgaca ggcgatagcg gtgcacctcc tgttcctcca      600

acaggtgatt ctggtgcccc tccggtgcca ccaactggcg attcaggtgc tccgccagtt      660

ccgccaacgg gtgacagtgg tgccccacca gtaccgccta caggggatag tggcgcaccg      720

ccagtgccac ctacaggtga ctcaggcgca ccacctgtac caccgactgg ggactcgggt      780

gcgcctccag tacctccgac tggtgacagc ggagcgccac ctgtcccacc aaccggtgat      840

gcaggtccac cgcctgtccc tccgacgggt gatagtggtg ctccgcctgt tccaccgact      900

ggtgattccg gtgcaccacc ggttacgccg actggcgaca gtgaaacagc tcctgtgcct      960

cctactggcg atagcggagc ccctccagtc ccacctacgg gtgattctga agcagctcca     1020

gttccaccaa ctgatgatag caaagaagct cctgtaccgc caactggtga tagtgaagcc     1080

acccctgttc cgcctacagg cgactctgaa accgcaccag tgcctccaac gggtgactcc     1140

ggtgctccac ctgtgcctcc gacaggcgac agtggcgcac caccggttcc accaactggt     1200

gactctgggg caccgccagt tcctccgact ggcgactctg gtgccccacc tgttccacct     1260

acgggtgaca gtggcgcacc tcctgtgcca ccgaccggtg acagcggtgc tcctccggtc     1320

cctcctaccg gtgactctgg tgctcctcca gtaccgccaa caggcgattc aggcgcacct     1380

ccggttcctc cgacgggtga cgcaggtccg cctccggttc ctcctacagg ggattcaggg     1440

gctccaccgg tgccaccgac tggtgatagt ggtgccccac cggtgacccc gacaggtgac     1500

agcgaaacag caccagttcc acctaccggt gattcgggtg ctccgcctgt acctccaact     1560

ggcgacagcg aagccgcacc ggtccctcca acagacgatt caaaagaagc aggatcc        1617


<210>  28
<211>  2178
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  M-IL1RA-G4SG4S-BSSL CTD (51, v1)-GS

<400>  28
atgcgtccga gcggtcgtaa aagcagcaaa atgcaggcat ttcgtatttg ggatgtgaac       60

cagaaaacct tttatctgcg taacaatcag ctggttgcag gttatctgca gggtccgaat      120

gttaatctgg aagaaaaaat tgatgtggtg ccgattgaac cgcatgcact gtttctgggt      180

attcatggtg gtaaaatgtg tctgagctgt gttaaaagcg gtgatgaaac ccgtctgcag      240

ctggaagcag tgaatatcac cgatctgagc gaaaatcgta aacaggataa acgctttgcc      300

tttattcgta gcgatagcgg tccgaccacc agttttgaaa gcgcagcatg tccgggttgg      360

tttctgtgta ccgcaatgga agcagatcag ccggttagcc tgaccaatat gccggatgaa      420

ggtgttatgg ttaccaaatt ctatttccaa gaggatgaag gcggtggtgg ttcaggtggt      480

ggtggatctc cggttccgcc taccggtgat agcgaagcaa caccggtgcc tccgaccggt      540

gattcagaaa ccgcaccggt tccaccgaca ggcgatagcg gtgcacctcc tgttcctcca      600

acaggtgatt ctggtgcccc tccggtgcca ccaactggcg attcaggtgc tccgccagtt      660

ccgccaacgg gtgacagtgg tgccccacca gtaccgccta caggggatag tggcgcaccg      720

ccagtgccac ctacaggtga ctcaggcgca ccacctgtac caccgactgg ggactcgggt      780

gcgcctccag tacctccgac tggtgacagc ggagcgccac ctgtcccacc tacgggtgat      840

tccggtgctc caccggtccc accgactggt gattctggcg caccgcctgt ccctccgaca      900

ggcgacagtg gcgcaccacc ggttccacca accggtgact caggtgcgcc tccggttcct      960

cctacaggcg attcaggggc acctccagtc ccaccaacag gggatagcgg agccccacca     1020

gttcctccga ctggggattc aggtgcccca cctgttccac cgaccggtga tagtggtgct     1080

ccacctgtgc ctccgactgg cgatagcgga gcccctccgg ttccacctac aggtgacagt     1140

ggtgcccctc cggttcctcc gacgggtgac tccggtgcac ctccagttcc acctactggc     1200

gatagtggcg cacctcctgt accgcctact ggcgacagcg gtgctccgcc tgtaccacct     1260

accggtgact ctggtgcccc accagtccct ccaacgggtg atagcggtgc tcctccagtc     1320

cctcctaccg gtgattcggg tgcacctcct gtgccaccta cgggtgacag cggtgcacca     1380

cctgtgccac caacaggcga ttctggcgca ccaccagttc cgcctacggg tgattctggc     1440

gctcctcctg ttccgccaac tggggactct ggggctccac cagtgccacc gaccggtgac     1500

agtggcgcac ctccagtgcc tccgaccggt gatagcggtg caccaccggt tccgcctact     1560

ggggactccg gtgcaccacc ggtgcctccg acaggtgata gtggtgctcc gccagttcca     1620

ccgaccggtg attccggtgc tccgcctgtt ccgcctacag gggattcagg cgctccacca     1680

gtgcctccaa caggcgactc cggtgctcct cctgtcccac cgacaggcga ctctggtgct     1740

ccgccagtgc ctcctactgg ggactctggt gcccctcctg ttccgcctac cggtgattca     1800

ggtgcaccac cagttccacc aacaggggac tcaggggcac cgccagtacc gccaactggt     1860

gattccggtg cgcctcctgt accgccaaca ggcgatagtg gtgccccacc ggtcccacca     1920

acaggcgact cgggtgcccc acctgtgcct ccaacaggtg atgcaggtcc gccaccggtc     1980

cctccaactg gggatagtgg tgcccctcct gtaccaccaa ctggtgacag tggcgcaccg     2040

cctgttaccc cgacgggtga ttcggagaca gcccctgttc caccaacggg tgatagcgga     2100

gcgcctccgg tgcctccaac tggtgatagc gaagcggcac cggttccgcc aacggatgat     2160

agcaaagaag caggatcc                                                   2178


<210>  29
<211>  2178
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  M-IL1RA-G4SG4S-BSSL CTD (51, v2)-GS

<400>  29
atgcgtccga gcggtcgtaa aagcagcaaa atgcaggcat ttcgtatttg ggatgtgaac       60

cagaaaacct tttatctgcg taacaatcag ctggttgcag gttatctgca gggtccgaat      120

gttaatctgg aagaaaaaat tgatgtggtg ccgattgaac cgcatgcact gtttctgggt      180

attcatggtg gtaaaatgtg tctgagctgt gttaaaagcg gtgatgaaac ccgtctgcag      240

ctggaagcag tgaatatcac cgatctgagc gaaaatcgta aacaggataa acgctttgcc      300

tttattcgta gcgatagcgg tccgaccacc agttttgaaa gcgcagcatg tccgggttgg      360

tttctgtgta ccgcaatgga agcagatcag ccggttagcc tgaccaatat gccggatgaa      420

ggtgttatgg ttaccaaatt ctatttccaa gaggatgaag gcggtggtgg ttcaggtggt      480

ggtggatctc cggttccgcc taccggtgat agcgaagcaa caccggtgcc tccgaccggt      540

gattcagaaa ccgcaccggt tccaccgaca ggcgatagcg gtgcacctcc tgttcctcca      600

acaggtgatt ctggtgcccc tccggtgcca ccaactggcg attcaggtgc tccgccagtt      660

ccgccaacgg gtgacagtgg tgccccacca gtaccgccta caggggatag tggcgcaccg      720

ccagtgccac ctacaggtga ctcaggcgca ccacctgtac caccgactgg ggactcgggt      780

gcgcctccag tacctccgac tggtgacagc ggagcgccac ctgtcccacc aaccggtgat      840

gcaggtccac cgcctgtccc tccgacgggt gatagtggtg ctccgcctgt tccaccgact      900

ggtgattccg gtgcaccacc ggttacgccg actggcgaca gtgaaacagc tcctgtgcct      960

cctactggcg atagcggagc ccctccagtc ccacctacgg gtgattctga agcagctcca     1020

gttccaccaa ctgatgatag caaagaagct cctgtaccgc caactggtga tagtgaagcc     1080

acccctgttc cgcctacagg cgactctgaa accgcaccag tgcctccaac gggtgactcc     1140

ggtgctccac ctgtgcctcc gacaggcgac agtggcgcac caccggttcc accaactggt     1200

gactctgggg caccgccagt tcctccgact ggcgactctg gtgccccacc tgttccacct     1260

acgggtgaca gtggcgcacc tcctgtgcca ccgaccggtg acagcggtgc tcctccggtc     1320

cctcctaccg gtgactctgg tgctcctcca gtaccgccaa caggcgattc aggcgcacct     1380

ccggttcctc cgacgggtga cgcaggtccg cctccggttc ctcctacagg ggattcaggg     1440

gctccaccgg tgccaccgac tggtgatagt ggtgccccac cggtgacccc gacaggtgac     1500

agcgaaacag caccagttcc acctaccggt gattcgggtg ctccgcctgt acctccaact     1560

ggcgacagcg aagccgcacc ggtccctcca acagacgatt caaaagaagc accagtccca     1620

ccaacagggg acagcgaagc gactcctgta cctcctacgg gtgactcaga aacagcccct     1680

gttccgccaa ccggtgactc gggtgcacct ccggttccac ctacaggtga cagcggagcc     1740

cctccggttc cgccaacagg cgatagtggt gctccaccag tccctccgac cggtgattct     1800

ggcgcacctc ctgttccgcc tactggggat agcggtgctc caccggttcc gcctacgggt     1860

gattctggcg caccaccggt gccacctacg ggtgattcag gtgccccacc ggttcctcca     1920

accggtgata gcggagcccc acctgttcct ccgactgggg atgcaggtcc tccgccagtg     1980

cctccaacag gggatagcgg agcgcctccg gtgccaccga caggggattc tggcgctcct     2040

ccagttactc ctacaggtga tagtgaaact gcgcctgtac caccaacagg cgactccggt     2100

gcacctccag tcccaccgac tggcgatagt gaagcagcac cggttccgcc aaccgacgac     2160

agcaaagaag caggatcc                                                   2178


<210>  30
<211>  2739
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  M-IL1RA-G4SG4S-BSSL CTD (68, v1)-GS

<400>  30
atgcgtccga gcggtcgtaa aagcagcaaa atgcaggcat ttcgtatttg ggatgtgaac       60

cagaaaacct tttatctgcg taacaatcag ctggttgcag gttatctgca gggtccgaat      120

gttaatctgg aagaaaaaat tgatgtggtg ccgattgaac cgcatgcact gtttctgggt      180

attcatggtg gtaaaatgtg tctgagctgt gttaaaagcg gtgatgaaac ccgtctgcag      240

ctggaagcag tgaatatcac cgatctgagc gaaaatcgta aacaggataa acgctttgcc      300

tttattcgta gcgatagcgg tccgaccacc agttttgaaa gcgcagcatg tccgggttgg      360

tttctgtgta ccgcaatgga agcagatcag ccggttagcc tgaccaatat gccggatgaa      420

ggtgttatgg ttaccaaatt ctatttccaa gaggatgaag gcggtggtgg ttcaggtggt      480

ggtggatctc cggttccgcc taccggtgat agcgaagcaa caccggttcc tccgacaggc      540

gatagtgaaa ccgcacctgt tccaccgacg ggtgattcag gtgcaccgcc tgttcctcca      600

actggtgaca gtggtgcacc tccggtgcca cctactggcg actcaggtgc tcctccagta      660

ccgccaacag gggattctgg cgctccgcca gttccaccta ctggagacag cggagcccca      720

ccagtgcctc cgacgggaga ctctggagcg ccacctgtac cacctaccgg agattcggga      780

gcaccacctg tccctccgac aggcgactcc ggagcaccgc cagtaccacc gactggcgat      840

agcggtgccc ctccggtccc tccaacaggt gattccggtg cgccaccagt gccaccaacc      900

ggtgactcag gcgcaccacc ggtcccacca acgggagata gtggggcacc accagttccg      960

cctacgggtg acagtggcgc tcctcctgtc cctcctactg gggatagcgg agcacctcct     1020

gttccgccaa cgggagactc gggagcccct ccagtcccac ctactggaga ttctggcgca     1080

cctccggtac ctccgaccgg tgacagcgga gcgcctcctg tgccaccgac aggtgatagt     1140

ggcgctccac cagtacctcc aactggcgat tcaggtgccc caccggttcc accgaccggt     1200

gacagtggtg ctccgcctgt accaccaacc ggtgattctg gtgctcctcc ggttcctcct     1260

acgggagatt caggtgcgcc tccggttccg cctacaggcg atagtggtgc gccaccggtt     1320

ccgccaactg gggattcggg tgcacctcct gtaccgccta cgggtgatag cggtgcgcct     1380

ccagttcctc cgactgggga ctccggtgcc cctcctgtgc ctccgaccgg agatagcggt     1440

gcaccacctg tcccacctac aggcgattcg ggtgctccac ctgtgcctcc aacaggcgac     1500

agcggagcac cgcctgtacc tccgacaggt gactcagggg cacctccagt tccaccgaca     1560

ggcgattctg gagcccctcc tgtaccacca actggcgaca gtggagcccc acctgttccg     1620

cctactggtg actctggagc gccaccggtt ccacctacag gcgatagcgg agcgccacct     1680

gtaccaccaa cgggtgactc gggtgcgcct ccggtgccac cgacgggaga cagtggagcc     1740

cctccggttc caccaaccgg agactccggt gctccgcctg ttcctccgac aggcgattct     1800

ggggcaccac cggtgccacc taccggtgac agcggtgcac cgccagtacc gcctactggg     1860

gactcagggg caccgcctgt gccacctact ggggattccg gagccccacc ggttccgcca     1920

acaggcgatt ctggagcgcc tccagtacct cctactgggg acagtggtgc cccaccagtt     1980

cctccaacgg gtgatagtgg agctccgcct gttcctccta caggcgatag tggggctcct     2040

ccagtgccac caactgggga tagtggtgcc cctcctgtcc caccgactgg ggactctggg     2100

gctcctcctg ttcctccaac aggggactct ggagctccac cggtaccacc gacaggcgac     2160

tcgggagccc caccagttcc gccaaccggt gacagcggtg cgccaccggt ccctccgacc     2220

ggtgatagtg gcgcaccgcc tgtaccgcca accggagata gtggagcgcc tccggtgcct     2280

cctaccggtg attctggggc accgccagtg cctccgactg gtgattcggg agcgcctcct     2340

gttcctccaa ccggagactc tggcgcacct ccagttccgc caacaggcga tagcggtgct     2400

ccgccagtcc caccgactgg tgactctggt gcaccaccag tcccacctac cggagattcc     2460

ggtgcccctc cagtaccacc tacaggtgac tcaggtgccc cacctgtacc tccgactgga     2520

gatgcaggtc cgccacctgt accgcctacg ggagactcag gcgctccacc agttcctccg     2580

accggtgact cgggtgctcc accggttacc cctacaggtg acagcgaaac agctcctgtt     2640

ccaccaactg gtgattccgg agcacctcca gtccctccga caggggattc agaagcagcc     2700

cctgttccac ctaccgatga tagtaaagaa gcaggatcc                            2739


<210>  31
<211>  2739
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  M-IL1RA-G4SG4S-BSSL CTD (68, v2)-GS

<400>  31
atgcgtccga gcggtcgtaa aagcagcaaa atgcaggcat ttcgtatttg ggatgtgaac       60

cagaaaacct tttatctgcg taacaatcag ctggttgcag gttatctgca gggtccgaat      120

gttaatctgg aagaaaaaat tgatgtggtg ccgattgaac cgcatgcact gtttctgggt      180

attcatggtg gtaaaatgtg tctgagctgt gttaaaagcg gtgatgaaac ccgtctgcag      240

ctggaagcag tgaatatcac cgatctgagc gaaaatcgta aacaggataa acgctttgcc      300

tttattcgta gcgatagcgg tccgaccacc agttttgaaa gcgcagcatg tccgggttgg      360

tttctgtgta ccgcaatgga agcagatcag ccggttagcc tgaccaatat gccggatgaa      420

ggtgttatgg ttaccaaatt ctatttccaa gaggatgaag gcggtggtgg ttcaggtggt      480

ggtggatctc cggttccgcc taccggtgat agcgaagcaa caccggtgcc tccgacaggt      540

gatagtgaaa ccgcaccggt tccaccaaca ggcgattcag gtgcaccgcc tgttccaccg      600

acgggtgaca gtggtgcacc tccggtccct ccaactgggg attctggcgc tccgccagtt      660

ccgccaacgg gagactctgg tgcccctcca gtaccgccta caggcgacag cggtgcgcca      720

ccagttcctc cgactggcga ctcgggagca ccgccagtgc ctccgaccgg agacagtgga      780

gccccacctg taccgccaac tggcgatagc ggagctcctc cggtgccacc tactggggat      840

gcaggtccgc ctcctgtacc accaaccgga gactccggag cgccaccggt acctccaacg      900

ggtgactcag gggcacctcc tgtgaccccg accggtgatt cagaaacagc accagtgcca      960

ccgacgggag atagcggagc accgcctgta ccgcctacag gtgattctga agcagcccct     1020

gttcctccaa ccgatgatag taaagaagcc ccagttccgc caaccggtga cagtgaggca     1080

accccagtac caccaactgg tgattccgag actgcacctg tccctccgac tggtgacagc     1140

ggtgccccac ctgtaccacc gaccggagat tctggtgctc cacctgtgcc tccgacgggt     1200

gattccggtg cccctccggt tcctcctacg ggagatagtg gtgcgcctcc tgtgccaccg     1260

acaggcgatt cgggagcgcc tccggtccca ccgactggag actccggtgc gcctcctgtt     1320

ccgccaactg gtgattcagg tgcgccaccg gtgccaccaa ccggagacag cggtgctccg     1380

ccagtgccac caacaggtga cgcaggtcct ccacctgttc ctccgacagg ggactcaggc     1440

gctccaccag tcccacctac aggcgatagt ggcgcaccac cggttacccc gacaggtgac     1500

agcgaaacag ccccagtacc tccaacaggg gatagcggag ccccaccagt tccacctact     1560

ggggattcag aagcggcacc tgtaccgcct acggatgata gcaaagaggc tcctgtacct     1620

cctactgggg acagtgaagc gacacctgtc ccaccaacag gtgactcaga aaccgctcct     1680

gtgcctccaa ccggagattc aggcgcacct ccagtccctc cgacaggtga ctctggggca     1740

ccaccggttc caccgactgg cgatagcggt gcccctccag tccctccaac cggtgattcg     1800

ggtgctcctc ctgtcccacc aacgggtgat agtggagcgc caccggttcc gcctacaggg     1860

gatagtgggg cacctccggt tccgccaact ggcgacagtg gcgctcctcc tgttcctcct     1920

acaggtgaca gcggagcacc tcctgtgcct ccgacgggag atgctggtcc gccaccagtt     1980

ccgccaacag gtgatagcgg tgcaccgcca gtaccaccta cgggagattc gggagcacca     2040

ccggtgacgc caactgggga ttccgaaaca gcgcctgtac cacctactgg tgacagtgga     2100

gccccacctg ttcctccgac cggtgatagc gaggctgcac ctgttccacc tacagatgat     2160

tcaaaagaag caccggtccc tccgacaggc gactccgaag ccactccagt tccaccgaca     2220

ggggatagtg aaacagcgcc agtccctcct actggcgatt ctggggcacc tccagtgcca     2280

ccaactgggg atagcggtgc gccacctgtg cctccaacag gggacagtgg cgcaccgcct     2340

gtgccaccta ccggtgatag cggagcccct cctgttcctc caacaggcga ctctggtgcg     2400

cctccggtgc ctccgacggg tgactcggga gcgccacctg tgccacctac tggagatagt     2460

ggtgcaccgc cagttcctcc gacaggcgat tccggtgctc ctccagttcc accgactgga     2520

gatgcaggtc ctcctccggt gcctccaaca ggcgatagtg gtgcacctcc tgtaccgcct     2580

accggagact cgggtgcacc gcctgtaacc ccgacaggcg atagcgagac tgctccggta     2640

cctccgacag gcgacagtgg agctccgcca gtacctccga cgggtgattc agaagctgca     2700

ccggttcctc cgacggacga cagcaaagaa gcaggatcc                            2739


<210>  32
<211>  2103
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  M-IL1RA-G4SG4S-BSSL CTD (34, v1)-GSG4SG4S-IL1RA

<400>  32
atgcgtccga gcggtcgtaa aagcagcaaa atgcaggcat ttcgtatttg ggatgtgaac       60

cagaaaacct tttatctgcg taacaatcag ctggttgcag gttatctgca gggtccgaat      120

gttaatctgg aagaaaaaat tgatgtggtg ccgattgaac cgcatgcact gtttctgggt      180

attcatggtg gtaaaatgtg tctgagctgt gttaaaagcg gtgatgaaac ccgtctgcag      240

ctggaagcag tgaatatcac cgatctgagc gaaaatcgta aacaggataa acgctttgcc      300

tttattcgta gcgatagcgg tccgaccacc agttttgaaa gcgcagcatg tccgggttgg      360

tttctgtgta ccgcaatgga agcagatcag ccggttagcc tgaccaatat gccggatgaa      420

ggtgttatgg ttaccaaatt ctatttccaa gaggatgaag gcggtggtgg ttcaggtggt      480

ggtggatctc cggttccgcc taccggtgat agcgaagcaa caccggtgcc tccgaccggt      540

gattcagaaa ccgcaccggt tccaccgaca ggcgatagcg gtgcacctcc tgttcctcca      600

acaggtgatt ctggtgcccc tccggtgcca ccaactggcg attcaggtgc tccgccagtt      660

ccgccaacgg gtgacagtgg tgccccacca gtaccgccta caggggatag tggcgcaccg      720

ccagtgccac ctacaggtga ctcaggcgca ccacctgtac caccgactgg ggactcgggt      780

gcgcctccag tacctccgac tggtgacagc ggagcgccac ctgtcccacc tacgggtgat      840

tccggtgctc caccggtccc accgactggt gattctggcg caccgcctgt ccctccgaca      900

ggcgacagtg gcgcaccacc ggttccacca accggtgact caggtgcgcc tccggttcct      960

cctacaggcg attcaggggc acctccagtc ccaccaacag gggatagcgg agccccacca     1020

gttcctccga ctggggattc aggtgcccca cctgttccac cgaccggtga tagtggtgct     1080

ccacctgtgc ctccgactgg cgatagcgga gcccctccgg ttccacctac aggtgacagt     1140

ggtgcccctc cggttcctcc gacgggtgac tccggtgcac ctccagttcc acctactggc     1200

gatagtggcg cacctcctgt accgcctact ggcgacagcg gtgctccgcc tgtaccacct     1260

accggtgact ctggtgcccc accagtccct ccaacgggtg atagcggtgc tcctccagtc     1320

cctcctaccg gtgattcggg tgcacctcct gtgccaccta cgggtgacag cggtgcacca     1380

cctgtgccac caactggtga tgccggtccg ccacctgtac cgccaaccgg tgatagcgga     1440

gcgcctcctg taccgccaac aggggattca ggcgctcctc ctgtgacgcc gacaggtgat     1500

tccgagacag cccctgttcc gccaacaggc gactcgggtg caccaccggt tccgcctacg     1560

ggtgattcag aagcagctcc ggttccgcca actgatgata gtaaagaagc aggatccggt     1620

ggtggtggta gcggtggtgg cggttcacgt ccgagcggtc gtaaaagcag caaaatgcag     1680

gcatttcgta tttgggatgt gaaccagaaa accttttatc tgcgtaacaa tcagctggtt     1740

gcaggttatc tgcagggtcc gaatgttaat ctggaagaaa aaattgatgt ggtgccgatt     1800

gaaccgcatg cactgtttct gggtattcat ggtggtaaaa tgtgtctgag ctgtgttaaa     1860

agcggtgatg aaacccgtct gcagctggaa gcagtgaata tcaccgatct gagcgaaaat     1920

cgtaaacagg ataaacgctt tgcctttatt cgtagcgata gcggtccgac caccagtttt     1980

gaaagcgcag catgtccggg ttggtttctg tgtaccgcaa tggaagcaga tcagccggtt     2040

agcctgacca atatgccgga tgaaggtgtt atggttacca aattctattt ccaagaggat     2100

gaa                                                                   2103


<210>  33
<211>  2103
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  M-IL1RA-G4SG4S-BSSL CTD (34, v2)-GSG4SG4S-IL1RA

<400>  33
atgcgtccga gcggtcgtaa aagcagcaaa atgcaggcat ttcgtatttg ggatgtgaac       60

cagaaaacct tttatctgcg taacaatcag ctggttgcag gttatctgca gggtccgaat      120

gttaatctgg aagaaaaaat tgatgtggtg ccgattgaac cgcatgcact gtttctgggt      180

attcatggtg gtaaaatgtg tctgagctgt gttaaaagcg gtgatgaaac ccgtctgcag      240

ctggaagcag tgaatatcac cgatctgagc gaaaatcgta aacaggataa acgctttgcc      300

tttattcgta gcgatagcgg tccgaccacc agttttgaaa gcgcagcatg tccgggttgg      360

tttctgtgta ccgcaatgga agcagatcag ccggttagcc tgaccaatat gccggatgaa      420

ggtgttatgg ttaccaaatt ctatttccaa gaggatgaag gcggtggtgg ttcaggtggt      480

ggtggatctc cggttccgcc taccggtgat agcgaagcaa caccggtgcc tccgaccggt      540

gattcagaaa ccgcaccggt tccaccgaca ggcgatagcg gtgcacctcc tgttcctcca      600

acaggtgatt ctggtgcccc tccggtgcca ccaactggcg attcaggtgc tccgccagtt      660

ccgccaacgg gtgacagtgg tgccccacca gtaccgccta caggggatag tggcgcaccg      720

ccagtgccac ctacaggtga ctcaggcgca ccacctgtac caccgactgg ggactcgggt      780

gcgcctccag tacctccgac tggtgacagc ggagcgccac ctgtcccacc aaccggtgat      840

gcaggtccac cgcctgtccc tccgacgggt gatagtggtg ctccgcctgt tccaccgact      900

ggtgattccg gtgcaccacc ggttacgccg actggcgaca gtgaaacagc tcctgtgcct      960

cctactggcg atagcggagc ccctccagtc ccacctacgg gtgattctga agcagctcca     1020

gttccaccaa ctgatgatag caaagaagct cctgtaccgc caactggtga tagtgaagcc     1080

acccctgttc cgcctacagg cgactctgaa accgcaccag tgcctccaac gggtgactcc     1140

ggtgctccac ctgtgcctcc gacaggcgac agtggcgcac caccggttcc accaactggt     1200

gactctgggg caccgccagt tcctccgact ggcgactctg gtgccccacc tgttccacct     1260

acgggtgaca gtggcgcacc tcctgtgcca ccgaccggtg acagcggtgc tcctccggtc     1320

cctcctaccg gtgactctgg tgctcctcca gtaccgccaa caggcgattc aggcgcacct     1380

ccggttcctc cgacgggtga cgcaggtccg cctccggttc ctcctacagg ggattcaggg     1440

gctccaccgg tgccaccgac tggtgatagt ggtgccccac cggtgacccc gacaggtgac     1500

agcgaaacag caccagttcc acctaccggt gattcgggtg ctccgcctgt acctccaact     1560

ggcgacagcg aagccgcacc ggtccctcca acagacgatt caaaagaagc aggatccggt     1620

ggtggtggta gcggtggtgg cggttcacgt ccgagcggtc gtaaaagcag caaaatgcag     1680

gcatttcgta tttgggatgt gaaccagaaa accttttatc tgcgtaacaa tcagctggtt     1740

gcaggttatc tgcagggtcc gaatgttaat ctggaagaaa aaattgatgt ggtgccgatt     1800

gaaccgcatg cactgtttct gggtattcat ggtggtaaaa tgtgtctgag ctgtgttaaa     1860

agcggtgatg aaacccgtct gcagctggaa gcagtgaata tcaccgatct gagcgaaaat     1920

cgtaaacagg ataaacgctt tgcctttatt cgtagcgata gcggtccgac caccagtttt     1980

gaaagcgcag catgtccggg ttggtttctg tgtaccgcaa tggaagcaga tcagccggtt     2040

agcctgacca atatgccgga tgaaggtgtt atggttacca aattctattt ccaagaggat     2100

gaa                                                                   2103


<210>  34
<211>  750
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Z06175(bb1)-GS-BSSL(r1-17)

<400>  34
atggccgaag caaaatatgc caaagaagtt ctggaagcct gggatgaaat tgatcgtctg       60

ccgaatctga ccattgaaca gtggctggcc tttattaaca aactggatga tgatccgagc      120

cagagcagcg aactgctgag cgaagccaaa aaactgagcg aaagtcaggc accgaaagga      180

tctccggttc cgcctaccgg tgatagcgaa gcaacaccgg tgcctccgac cggtgattca      240

gaaaccgcac cggttccacc gacaggcgat agcggtgcac ctcctgttcc tccaacaggt      300

gattctggtg cccctccggt gccaccaact ggcgattcag gtgctccgcc agttccgcca      360

acgggtgaca gtggtgcccc accagtaccg cctacagggg atagtggcgc accgccagtg      420

ccacctacag gtgactcagg cgcaccacct gtaccaccga ctggggactc gggtgcgcct      480

ccagtacctc cgactggtga cagcggagcg ccacctgtcc caccaaccgg tgatgcaggt      540

ccaccgcctg tccctccgac gggtgatagt ggtgctccgc ctgttccacc gactggtgat      600

tccggtgcac caccggttac gccgactggc gacagtgaaa cagctcctgt gcctcctact      660

ggcgatagcg gagcccctcc agtcccacct acgggtgatt ctgaagcagc tccagttcca      720

ccaactgatg atagcaaaga agcaggatcc                                       750


<210>  35
<211>  153
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  M-IL-1Ra (Anakinra)

<400>  35

Met Arg Pro Ser Gly Arg Lys Ser Ser Lys Met Gln Ala Phe Arg Ile 
1               5                   10                  15      


Trp Asp Val Asn Gln Lys Thr Phe Tyr Leu Arg Asn Asn Gln Leu Val 
            20                  25                  30          


Ala Gly Tyr Leu Gln Gly Pro Asn Val Asn Leu Glu Glu Lys Ile Asp 
        35                  40                  45              


Val Val Pro Ile Glu Pro His Ala Leu Phe Leu Gly Ile His Gly Gly 
    50                  55                  60                  


Lys Met Cys Leu Ser Cys Val Lys Ser Gly Asp Glu Thr Arg Leu Gln 
65                  70                  75                  80  


Leu Glu Ala Val Asn Ile Thr Asp Leu Ser Glu Asn Arg Lys Gln Asp 
                85                  90                  95      


Lys Arg Phe Ala Phe Ile Arg Ser Asp Ser Gly Pro Thr Thr Ser Phe 
            100                 105                 110         


Glu Ser Ala Ala Cys Pro Gly Trp Phe Leu Cys Thr Ala Met Glu Ala 
        115                 120                 125             


Asp Gln Pro Val Ser Leu Thr Asn Met Pro Asp Glu Gly Val Met Val 
    130                 135                 140                 


Thr Lys Phe Tyr Phe Gln Glu Asp Glu 
145                 150             


<210>  36
<211>  62
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Z06175-GS

<400>  36

Ala Glu Ala Lys Tyr Ala Lys Glu Val Leu Glu Ala Trp Asp Glu Ile 
1               5                   10                  15      


Asp Arg Leu Pro Asn Leu Thr Ile Glu Gln Trp Leu Ala Phe Ile Asn 
            20                  25                  30          


Lys Leu Asp Asp Asp Pro Ser Gln Ser Ser Glu Leu Leu Ser Glu Ala 
        35                  40                  45              


Lys Lys Leu Asn Asp Ser Gln Ala Pro Lys Val Asp Gly Ser 
    50                  55                  60          


<210>  37
<211>  249
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Z06175(bb1)-GS-BSSL(r1-17) pBV2428

<400>  37

Ala Glu Ala Lys Tyr Ala Lys Glu Val Leu Glu Ala Trp Asp Glu Ile 
1               5                   10                  15      


Asp Arg Leu Pro Asn Leu Thr Ile Glu Gln Trp Leu Ala Phe Ile Asn 
            20                  25                  30          


Lys Leu Asp Asp Asp Pro Ser Gln Ser Ser Glu Leu Leu Ser Glu Ala 
        35                  40                  45              


Lys Lys Leu Ser Glu Ser Gln Ala Pro Lys Gly Ser Pro Val Pro Pro 
    50                  55                  60                  


Thr Gly Asp Ser Glu Ala Thr Pro Val Pro Pro Thr Gly Asp Ser Glu 
65                  70                  75                  80  


Thr Ala Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro 
                85                  90                  95      


Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser 
            100                 105                 110         


Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val 
        115                 120                 125             


Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp 
    130                 135                 140                 


Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro 
145                 150                 155                 160 


Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly 
                165                 170                 175     


Asp Ala Gly Pro Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro 
            180                 185                 190         


Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Thr Pro Thr 
        195                 200                 205             


Gly Asp Ser Glu Thr Ala Pro Val Pro Pro Thr Gly Asp Ser Gly Ala 
    210                 215                 220                 


Pro Pro Val Pro Pro Thr Gly Asp Ser Glu Ala Ala Pro Val Pro Pro 
225                 230                 235                 240 


Thr Asp Asp Ser Lys Glu Ala Gly Ser 
                245                 


<210>  38
<211>  356
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL1RA-G4SG4SG4S-BSSL CTD (17)

<400>  38

Arg Pro Ser Gly Arg Lys Ser Ser Lys Met Gln Ala Phe Arg Ile Trp 
1               5                   10                  15      


Asp Val Asn Gln Lys Thr Phe Tyr Leu Arg Asn Asn Gln Leu Val Ala 
            20                  25                  30          


Gly Tyr Leu Gln Gly Pro Asn Val Asn Leu Glu Glu Lys Ile Asp Val 
        35                  40                  45              


Val Pro Ile Glu Pro His Ala Leu Phe Leu Gly Ile His Gly Gly Lys 
    50                  55                  60                  


Met Cys Leu Ser Cys Val Lys Ser Gly Asp Glu Thr Arg Leu Gln Leu 
65                  70                  75                  80  


Glu Ala Val Asn Ile Thr Asp Leu Ser Glu Asn Arg Lys Gln Asp Lys 
                85                  90                  95      


Arg Phe Ala Phe Ile Arg Ser Asp Ser Gly Pro Thr Thr Ser Phe Glu 
            100                 105                 110         


Ser Ala Ala Cys Pro Gly Trp Phe Leu Cys Thr Ala Met Glu Ala Asp 
        115                 120                 125             


Gln Pro Val Ser Leu Thr Asn Met Pro Asp Glu Gly Val Met Val Thr 
    130                 135                 140                 


Lys Phe Tyr Phe Gln Glu Asp Glu Gly Gly Gly Gly Ser Gly Gly Gly 
145                 150                 155                 160 


Gly Ser Gly Gly Gly Gly Ser Pro Val Pro Pro Thr Gly Asp Ser Glu 
                165                 170                 175     


Ala Thr Pro Val Pro Pro Thr Gly Asp Ser Glu Thr Ala Pro Val Pro 
            180                 185                 190         


Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser 
        195                 200                 205             


Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val 
    210                 215                 220                 


Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp 
225                 230                 235                 240 


Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro 
                245                 250                 255     


Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly 
            260                 265                 270         


Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ala Gly Pro Pro 
        275                 280                 285             


Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr 
    290                 295                 300                 


Gly Asp Ser Gly Ala Pro Pro Val Thr Pro Thr Gly Asp Ser Glu Thr 
305                 310                 315                 320 


Ala Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro 
                325                 330                 335     


Thr Gly Asp Ser Glu Ala Ala Pro Val Pro Pro Thr Asp Asp Ser Lys 
            340                 345                 350         


Glu Ala Gly Ser 
        355     


<210>  39
<211>  508
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL1RA-G4SG4SG4S-BSSL CTD (17)-GS-IL1RA

<400>  39

Arg Pro Ser Gly Arg Lys Ser Ser Lys Met Gln Ala Phe Arg Ile Trp 
1               5                   10                  15      


Asp Val Asn Gln Lys Thr Phe Tyr Leu Arg Asn Asn Gln Leu Val Ala 
            20                  25                  30          


Gly Tyr Leu Gln Gly Pro Asn Val Asn Leu Glu Glu Lys Ile Asp Val 
        35                  40                  45              


Val Pro Ile Glu Pro His Ala Leu Phe Leu Gly Ile His Gly Gly Lys 
    50                  55                  60                  


Met Cys Leu Ser Cys Val Lys Ser Gly Asp Glu Thr Arg Leu Gln Leu 
65                  70                  75                  80  


Glu Ala Val Asn Ile Thr Asp Leu Ser Glu Asn Arg Lys Gln Asp Lys 
                85                  90                  95      


Arg Phe Ala Phe Ile Arg Ser Asp Ser Gly Pro Thr Thr Ser Phe Glu 
            100                 105                 110         


Ser Ala Ala Cys Pro Gly Trp Phe Leu Cys Thr Ala Met Glu Ala Asp 
        115                 120                 125             


Gln Pro Val Ser Leu Thr Asn Met Pro Asp Glu Gly Val Met Val Thr 
    130                 135                 140                 


Lys Phe Tyr Phe Gln Glu Asp Glu Gly Gly Gly Gly Ser Gly Gly Gly 
145                 150                 155                 160 


Gly Ser Gly Gly Gly Gly Ser Pro Val Pro Pro Thr Gly Asp Ser Glu 
                165                 170                 175     


Ala Thr Pro Val Pro Pro Thr Gly Asp Ser Glu Thr Ala Pro Val Pro 
            180                 185                 190         


Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser 
        195                 200                 205             


Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val 
    210                 215                 220                 


Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp 
225                 230                 235                 240 


Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro 
                245                 250                 255     


Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly 
            260                 265                 270         


Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ala Gly Pro Pro 
        275                 280                 285             


Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr 
    290                 295                 300                 


Gly Asp Ser Gly Ala Pro Pro Val Thr Pro Thr Gly Asp Ser Glu Thr 
305                 310                 315                 320 


Ala Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro 
                325                 330                 335     


Thr Gly Asp Ser Glu Ala Ala Pro Val Pro Pro Thr Asp Asp Ser Lys 
            340                 345                 350         


Glu Ala Gly Ser Arg Pro Ser Gly Arg Lys Ser Ser Lys Met Gln Ala 
        355                 360                 365             


Phe Arg Ile Trp Asp Val Asn Gln Lys Thr Phe Tyr Leu Arg Asn Asn 
    370                 375                 380                 


Gln Leu Val Ala Gly Tyr Leu Gln Gly Pro Asn Val Asn Leu Glu Glu 
385                 390                 395                 400 


Lys Ile Asp Val Val Pro Ile Glu Pro His Ala Leu Phe Leu Gly Ile 
                405                 410                 415     


His Gly Gly Lys Met Cys Leu Ser Cys Val Lys Ser Gly Asp Glu Thr 
            420                 425                 430         


Arg Leu Gln Leu Glu Ala Val Asn Ile Thr Asp Leu Ser Glu Asn Arg 
        435                 440                 445             


Lys Gln Asp Lys Arg Phe Ala Phe Ile Arg Ser Asp Ser Gly Pro Thr 
    450                 455                 460                 


Thr Ser Phe Glu Ser Ala Ala Cys Pro Gly Trp Phe Leu Cys Thr Ala 
465                 470                 475                 480 


Met Glu Ala Asp Gln Pro Val Ser Leu Thr Asn Met Pro Asp Glu Gly 
                485                 490                 495     


Val Met Val Thr Lys Phe Tyr Phe Gln Glu Asp Glu 
            500                 505             


<210>  40
<211>  543
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL1RA-G4SG4SG4S-BSSL CTD (34, v1)-GS

<400>  40

Arg Pro Ser Gly Arg Lys Ser Ser Lys Met Gln Ala Phe Arg Ile Trp 
1               5                   10                  15      


Asp Val Asn Gln Lys Thr Phe Tyr Leu Arg Asn Asn Gln Leu Val Ala 
            20                  25                  30          


Gly Tyr Leu Gln Gly Pro Asn Val Asn Leu Glu Glu Lys Ile Asp Val 
        35                  40                  45              


Val Pro Ile Glu Pro His Ala Leu Phe Leu Gly Ile His Gly Gly Lys 
    50                  55                  60                  


Met Cys Leu Ser Cys Val Lys Ser Gly Asp Glu Thr Arg Leu Gln Leu 
65                  70                  75                  80  


Glu Ala Val Asn Ile Thr Asp Leu Ser Glu Asn Arg Lys Gln Asp Lys 
                85                  90                  95      


Arg Phe Ala Phe Ile Arg Ser Asp Ser Gly Pro Thr Thr Ser Phe Glu 
            100                 105                 110         


Ser Ala Ala Cys Pro Gly Trp Phe Leu Cys Thr Ala Met Glu Ala Asp 
        115                 120                 125             


Gln Pro Val Ser Leu Thr Asn Met Pro Asp Glu Gly Val Met Val Thr 
    130                 135                 140                 


Lys Phe Tyr Phe Gln Glu Asp Glu Gly Gly Gly Gly Ser Gly Gly Gly 
145                 150                 155                 160 


Gly Ser Gly Gly Gly Gly Ser Pro Val Pro Pro Thr Gly Asp Ser Glu 
                165                 170                 175     


Ala Thr Pro Val Pro Pro Thr Gly Asp Ser Glu Thr Ala Pro Val Pro 
            180                 185                 190         


Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser 
        195                 200                 205             


Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val 
    210                 215                 220                 


Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp 
225                 230                 235                 240 


Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro 
                245                 250                 255     


Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly 
            260                 265                 270         


Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro 
        275                 280                 285             


Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr 
    290                 295                 300                 


Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala 
305                 310                 315                 320 


Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro 
                325                 330                 335     


Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Gly 
            340                 345                 350         


Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro 
        355                 360                 365             


Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser 
    370                 375                 380                 


Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val 
385                 390                 395                 400 


Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp 
                405                 410                 415     


Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro 
            420                 425                 430         


Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly 
        435                 440                 445             


Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro 
    450                 455                 460                 


Pro Val Pro Pro Thr Gly Asp Ala Gly Pro Pro Pro Val Pro Pro Thr 
465                 470                 475                 480 


Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala 
                485                 490                 495     


Pro Pro Val Thr Pro Thr Gly Asp Ser Glu Thr Ala Pro Val Pro Pro 
            500                 505                 510         


Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Glu 
        515                 520                 525             


Ala Ala Pro Val Pro Pro Thr Asp Asp Ser Lys Glu Ala Gly Ser 
    530                 535                 540             


<210>  41
<211>  543
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL1RA-G4SG4SG4S-BSSL CTD (34, v2)-GS

<400>  41

Arg Pro Ser Gly Arg Lys Ser Ser Lys Met Gln Ala Phe Arg Ile Trp 
1               5                   10                  15      


Asp Val Asn Gln Lys Thr Phe Tyr Leu Arg Asn Asn Gln Leu Val Ala 
            20                  25                  30          


Gly Tyr Leu Gln Gly Pro Asn Val Asn Leu Glu Glu Lys Ile Asp Val 
        35                  40                  45              


Val Pro Ile Glu Pro His Ala Leu Phe Leu Gly Ile His Gly Gly Lys 
    50                  55                  60                  


Met Cys Leu Ser Cys Val Lys Ser Gly Asp Glu Thr Arg Leu Gln Leu 
65                  70                  75                  80  


Glu Ala Val Asn Ile Thr Asp Leu Ser Glu Asn Arg Lys Gln Asp Lys 
                85                  90                  95      


Arg Phe Ala Phe Ile Arg Ser Asp Ser Gly Pro Thr Thr Ser Phe Glu 
            100                 105                 110         


Ser Ala Ala Cys Pro Gly Trp Phe Leu Cys Thr Ala Met Glu Ala Asp 
        115                 120                 125             


Gln Pro Val Ser Leu Thr Asn Met Pro Asp Glu Gly Val Met Val Thr 
    130                 135                 140                 


Lys Phe Tyr Phe Gln Glu Asp Glu Gly Gly Gly Gly Ser Gly Gly Gly 
145                 150                 155                 160 


Gly Ser Gly Gly Gly Gly Ser Pro Val Pro Pro Thr Gly Asp Ser Glu 
                165                 170                 175     


Ala Thr Pro Val Pro Pro Thr Gly Asp Ser Glu Thr Ala Pro Val Pro 
            180                 185                 190         


Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser 
        195                 200                 205             


Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val 
    210                 215                 220                 


Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp 
225                 230                 235                 240 


Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro 
                245                 250                 255     


Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly 
            260                 265                 270         


Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ala Gly Pro Pro 
        275                 280                 285             


Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr 
    290                 295                 300                 


Gly Asp Ser Gly Ala Pro Pro Val Thr Pro Thr Gly Asp Ser Glu Thr 
305                 310                 315                 320 


Ala Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro 
                325                 330                 335     


Thr Gly Asp Ser Glu Ala Ala Pro Val Pro Pro Thr Asp Asp Ser Lys 
            340                 345                 350         


Glu Ala Pro Val Pro Pro Thr Gly Asp Ser Glu Ala Thr Pro Val Pro 
        355                 360                 365             


Pro Thr Gly Asp Ser Glu Thr Ala Pro Val Pro Pro Thr Gly Asp Ser 
    370                 375                 380                 


Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val 
385                 390                 395                 400 


Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp 
                405                 410                 415     


Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro 
            420                 425                 430         


Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly 
        435                 440                 445             


Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro 
    450                 455                 460                 


Pro Val Pro Pro Thr Gly Asp Ala Gly Pro Pro Pro Val Pro Pro Thr 
465                 470                 475                 480 


Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala 
                485                 490                 495     


Pro Pro Val Thr Pro Thr Gly Asp Ser Glu Thr Ala Pro Val Pro Pro 
            500                 505                 510         


Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Glu 
        515                 520                 525             


Ala Ala Pro Val Pro Pro Thr Asp Asp Ser Lys Glu Ala Gly Ser 
    530                 535                 540             


<210>  42
<211>  539
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  M-IL1RA-G4SG4S-BSSL CTD (34, v1)-GS

<400>  42

Met Arg Pro Ser Gly Arg Lys Ser Ser Lys Met Gln Ala Phe Arg Ile 
1               5                   10                  15      


Trp Asp Val Asn Gln Lys Thr Phe Tyr Leu Arg Asn Asn Gln Leu Val 
            20                  25                  30          


Ala Gly Tyr Leu Gln Gly Pro Asn Val Asn Leu Glu Glu Lys Ile Asp 
        35                  40                  45              


Val Val Pro Ile Glu Pro His Ala Leu Phe Leu Gly Ile His Gly Gly 
    50                  55                  60                  


Lys Met Cys Leu Ser Cys Val Lys Ser Gly Asp Glu Thr Arg Leu Gln 
65                  70                  75                  80  


Leu Glu Ala Val Asn Ile Thr Asp Leu Ser Glu Asn Arg Lys Gln Asp 
                85                  90                  95      


Lys Arg Phe Ala Phe Ile Arg Ser Asp Ser Gly Pro Thr Thr Ser Phe 
            100                 105                 110         


Glu Ser Ala Ala Cys Pro Gly Trp Phe Leu Cys Thr Ala Met Glu Ala 
        115                 120                 125             


Asp Gln Pro Val Ser Leu Thr Asn Met Pro Asp Glu Gly Val Met Val 
    130                 135                 140                 


Thr Lys Phe Tyr Phe Gln Glu Asp Glu Gly Gly Gly Gly Ser Gly Gly 
145                 150                 155                 160 


Gly Gly Ser Pro Val Pro Pro Thr Gly Asp Ser Glu Ala Thr Pro Val 
                165                 170                 175     


Pro Pro Thr Gly Asp Ser Glu Thr Ala Pro Val Pro Pro Thr Gly Asp 
            180                 185                 190         


Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro 
        195                 200                 205             


Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly 
    210                 215                 220                 


Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro 
225                 230                 235                 240 


Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr 
                245                 250                 255     


Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala 
            260                 265                 270         


Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro 
        275                 280                 285             


Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Gly 
    290                 295                 300                 


Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro 
305                 310                 315                 320 


Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser 
                325                 330                 335     


Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val 
            340                 345                 350         


Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp 
        355                 360                 365             


Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro 
    370                 375                 380                 


Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly 
385                 390                 395                 400 


Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro 
                405                 410                 415     


Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr 
            420                 425                 430         


Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala 
        435                 440                 445             


Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro 
    450                 455                 460                 


Thr Gly Asp Ala Gly Pro Pro Pro Val Pro Pro Thr Gly Asp Ser Gly 
465                 470                 475                 480 


Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Thr 
                485                 490                 495     


Pro Thr Gly Asp Ser Glu Thr Ala Pro Val Pro Pro Thr Gly Asp Ser 
            500                 505                 510         


Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Glu Ala Ala Pro Val 
        515                 520                 525             


Pro Pro Thr Asp Asp Ser Lys Glu Ala Gly Ser 
    530                 535                 


<210>  43
<211>  539
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  M- IL1RA-G4SG4S-BSSL CTD (34, v2)-GS

<400>  43

Met Arg Pro Ser Gly Arg Lys Ser Ser Lys Met Gln Ala Phe Arg Ile 
1               5                   10                  15      


Trp Asp Val Asn Gln Lys Thr Phe Tyr Leu Arg Asn Asn Gln Leu Val 
            20                  25                  30          


Ala Gly Tyr Leu Gln Gly Pro Asn Val Asn Leu Glu Glu Lys Ile Asp 
        35                  40                  45              


Val Val Pro Ile Glu Pro His Ala Leu Phe Leu Gly Ile His Gly Gly 
    50                  55                  60                  


Lys Met Cys Leu Ser Cys Val Lys Ser Gly Asp Glu Thr Arg Leu Gln 
65                  70                  75                  80  


Leu Glu Ala Val Asn Ile Thr Asp Leu Ser Glu Asn Arg Lys Gln Asp 
                85                  90                  95      


Lys Arg Phe Ala Phe Ile Arg Ser Asp Ser Gly Pro Thr Thr Ser Phe 
            100                 105                 110         


Glu Ser Ala Ala Cys Pro Gly Trp Phe Leu Cys Thr Ala Met Glu Ala 
        115                 120                 125             


Asp Gln Pro Val Ser Leu Thr Asn Met Pro Asp Glu Gly Val Met Val 
    130                 135                 140                 


Thr Lys Phe Tyr Phe Gln Glu Asp Glu Gly Gly Gly Gly Ser Gly Gly 
145                 150                 155                 160 


Gly Gly Ser Pro Val Pro Pro Thr Gly Asp Ser Glu Ala Thr Pro Val 
                165                 170                 175     


Pro Pro Thr Gly Asp Ser Glu Thr Ala Pro Val Pro Pro Thr Gly Asp 
            180                 185                 190         


Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro 
        195                 200                 205             


Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly 
    210                 215                 220                 


Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro 
225                 230                 235                 240 


Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr 
                245                 250                 255     


Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala 
            260                 265                 270         


Pro Pro Val Pro Pro Thr Gly Asp Ala Gly Pro Pro Pro Val Pro Pro 
        275                 280                 285             


Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Gly 
    290                 295                 300                 


Ala Pro Pro Val Thr Pro Thr Gly Asp Ser Glu Thr Ala Pro Val Pro 
305                 310                 315                 320 


Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser 
                325                 330                 335     


Glu Ala Ala Pro Val Pro Pro Thr Asp Asp Ser Lys Glu Ala Pro Val 
            340                 345                 350         


Pro Pro Thr Gly Asp Ser Glu Ala Thr Pro Val Pro Pro Thr Gly Asp 
        355                 360                 365             


Ser Glu Thr Ala Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro 
    370                 375                 380                 


Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly 
385                 390                 395                 400 


Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro 
                405                 410                 415     


Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr 
            420                 425                 430         


Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala 
        435                 440                 445             


Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro 
    450                 455                 460                 


Thr Gly Asp Ala Gly Pro Pro Pro Val Pro Pro Thr Gly Asp Ser Gly 
465                 470                 475                 480 


Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Thr 
                485                 490                 495     


Pro Thr Gly Asp Ser Glu Thr Ala Pro Val Pro Pro Thr Gly Asp Ser 
            500                 505                 510         


Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Glu Ala Ala Pro Val 
        515                 520                 525             


Pro Pro Thr Asp Asp Ser Lys Glu Ala Gly Ser 
    530                 535                 


<210>  44
<211>  726
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  M-IL1RA-G4SG4S-BSSL CTD (51, v1)-GS

<400>  44

Met Arg Pro Ser Gly Arg Lys Ser Ser Lys Met Gln Ala Phe Arg Ile 
1               5                   10                  15      


Trp Asp Val Asn Gln Lys Thr Phe Tyr Leu Arg Asn Asn Gln Leu Val 
            20                  25                  30          


Ala Gly Tyr Leu Gln Gly Pro Asn Val Asn Leu Glu Glu Lys Ile Asp 
        35                  40                  45              


Val Val Pro Ile Glu Pro His Ala Leu Phe Leu Gly Ile His Gly Gly 
    50                  55                  60                  


Lys Met Cys Leu Ser Cys Val Lys Ser Gly Asp Glu Thr Arg Leu Gln 
65                  70                  75                  80  


Leu Glu Ala Val Asn Ile Thr Asp Leu Ser Glu Asn Arg Lys Gln Asp 
                85                  90                  95      


Lys Arg Phe Ala Phe Ile Arg Ser Asp Ser Gly Pro Thr Thr Ser Phe 
            100                 105                 110         


Glu Ser Ala Ala Cys Pro Gly Trp Phe Leu Cys Thr Ala Met Glu Ala 
        115                 120                 125             


Asp Gln Pro Val Ser Leu Thr Asn Met Pro Asp Glu Gly Val Met Val 
    130                 135                 140                 


Thr Lys Phe Tyr Phe Gln Glu Asp Glu Gly Gly Gly Gly Ser Gly Gly 
145                 150                 155                 160 


Gly Gly Ser Pro Val Pro Pro Thr Gly Asp Ser Glu Ala Thr Pro Val 
                165                 170                 175     


Pro Pro Thr Gly Asp Ser Glu Thr Ala Pro Val Pro Pro Thr Gly Asp 
            180                 185                 190         


Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro 
        195                 200                 205             


Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly 
    210                 215                 220                 


Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro 
225                 230                 235                 240 


Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr 
                245                 250                 255     


Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala 
            260                 265                 270         


Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro 
        275                 280                 285             


Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Gly 
    290                 295                 300                 


Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro 
305                 310                 315                 320 


Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser 
                325                 330                 335     


Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val 
            340                 345                 350         


Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp 
        355                 360                 365             


Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro 
    370                 375                 380                 


Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly 
385                 390                 395                 400 


Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro 
                405                 410                 415     


Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr 
            420                 425                 430         


Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala 
        435                 440                 445             


Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro 
    450                 455                 460                 


Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Gly 
465                 470                 475                 480 


Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro 
                485                 490                 495     


Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser 
            500                 505                 510         


Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val 
        515                 520                 525             


Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp 
    530                 535                 540                 


Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro 
545                 550                 555                 560 


Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly 
                565                 570                 575     


Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro 
            580                 585                 590         


Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr 
        595                 600                 605             


Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala 
    610                 615                 620                 


Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro 
625                 630                 635                 640 


Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ala Gly 
                645                 650                 655     


Pro Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro 
            660                 665                 670         


Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Thr Pro Thr Gly Asp Ser 
        675                 680                 685             


Glu Thr Ala Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val 
    690                 695                 700                 


Pro Pro Thr Gly Asp Ser Glu Ala Ala Pro Val Pro Pro Thr Asp Asp 
705                 710                 715                 720 


Ser Lys Glu Ala Gly Ser 
                725     


<210>  45
<211>  726
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  M-IL1RA-G4SG4S-BSSL CTD (51, v2)-GS

<400>  45

Met Arg Pro Ser Gly Arg Lys Ser Ser Lys Met Gln Ala Phe Arg Ile 
1               5                   10                  15      


Trp Asp Val Asn Gln Lys Thr Phe Tyr Leu Arg Asn Asn Gln Leu Val 
            20                  25                  30          


Ala Gly Tyr Leu Gln Gly Pro Asn Val Asn Leu Glu Glu Lys Ile Asp 
        35                  40                  45              


Val Val Pro Ile Glu Pro His Ala Leu Phe Leu Gly Ile His Gly Gly 
    50                  55                  60                  


Lys Met Cys Leu Ser Cys Val Lys Ser Gly Asp Glu Thr Arg Leu Gln 
65                  70                  75                  80  


Leu Glu Ala Val Asn Ile Thr Asp Leu Ser Glu Asn Arg Lys Gln Asp 
                85                  90                  95      


Lys Arg Phe Ala Phe Ile Arg Ser Asp Ser Gly Pro Thr Thr Ser Phe 
            100                 105                 110         


Glu Ser Ala Ala Cys Pro Gly Trp Phe Leu Cys Thr Ala Met Glu Ala 
        115                 120                 125             


Asp Gln Pro Val Ser Leu Thr Asn Met Pro Asp Glu Gly Val Met Val 
    130                 135                 140                 


Thr Lys Phe Tyr Phe Gln Glu Asp Glu Gly Gly Gly Gly Ser Gly Gly 
145                 150                 155                 160 


Gly Gly Ser Pro Val Pro Pro Thr Gly Asp Ser Glu Ala Thr Pro Val 
                165                 170                 175     


Pro Pro Thr Gly Asp Ser Glu Thr Ala Pro Val Pro Pro Thr Gly Asp 
            180                 185                 190         


Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro 
        195                 200                 205             


Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly 
    210                 215                 220                 


Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro 
225                 230                 235                 240 


Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr 
                245                 250                 255     


Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala 
            260                 265                 270         


Pro Pro Val Pro Pro Thr Gly Asp Ala Gly Pro Pro Pro Val Pro Pro 
        275                 280                 285             


Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Gly 
    290                 295                 300                 


Ala Pro Pro Val Thr Pro Thr Gly Asp Ser Glu Thr Ala Pro Val Pro 
305                 310                 315                 320 


Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser 
                325                 330                 335     


Glu Ala Ala Pro Val Pro Pro Thr Asp Asp Ser Lys Glu Ala Pro Val 
            340                 345                 350         


Pro Pro Thr Gly Asp Ser Glu Ala Thr Pro Val Pro Pro Thr Gly Asp 
        355                 360                 365             


Ser Glu Thr Ala Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro 
    370                 375                 380                 


Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly 
385                 390                 395                 400 


Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro 
                405                 410                 415     


Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr 
            420                 425                 430         


Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala 
        435                 440                 445             


Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro 
    450                 455                 460                 


Thr Gly Asp Ala Gly Pro Pro Pro Val Pro Pro Thr Gly Asp Ser Gly 
465                 470                 475                 480 


Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Thr 
                485                 490                 495     


Pro Thr Gly Asp Ser Glu Thr Ala Pro Val Pro Pro Thr Gly Asp Ser 
            500                 505                 510         


Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Glu Ala Ala Pro Val 
        515                 520                 525             


Pro Pro Thr Asp Asp Ser Lys Glu Ala Pro Val Pro Pro Thr Gly Asp 
    530                 535                 540                 


Ser Glu Ala Thr Pro Val Pro Pro Thr Gly Asp Ser Glu Thr Ala Pro 
545                 550                 555                 560 


Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly 
                565                 570                 575     


Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro 
            580                 585                 590         


Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr 
        595                 600                 605             


Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala 
    610                 615                 620                 


Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro 
625                 630                 635                 640 


Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ala Gly 
                645                 650                 655     


Pro Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro 
            660                 665                 670         


Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Thr Pro Thr Gly Asp Ser 
        675                 680                 685             


Glu Thr Ala Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val 
    690                 695                 700                 


Pro Pro Thr Gly Asp Ser Glu Ala Ala Pro Val Pro Pro Thr Asp Asp 
705                 710                 715                 720 


Ser Lys Glu Ala Gly Ser 
                725     


<210>  46
<211>  913
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  M-IL1RA-G4SG4S-BSSL CTD (68, v1)-GS

<400>  46

Met Arg Pro Ser Gly Arg Lys Ser Ser Lys Met Gln Ala Phe Arg Ile 
1               5                   10                  15      


Trp Asp Val Asn Gln Lys Thr Phe Tyr Leu Arg Asn Asn Gln Leu Val 
            20                  25                  30          


Ala Gly Tyr Leu Gln Gly Pro Asn Val Asn Leu Glu Glu Lys Ile Asp 
        35                  40                  45              


Val Val Pro Ile Glu Pro His Ala Leu Phe Leu Gly Ile His Gly Gly 
    50                  55                  60                  


Lys Met Cys Leu Ser Cys Val Lys Ser Gly Asp Glu Thr Arg Leu Gln 
65                  70                  75                  80  


Leu Glu Ala Val Asn Ile Thr Asp Leu Ser Glu Asn Arg Lys Gln Asp 
                85                  90                  95      


Lys Arg Phe Ala Phe Ile Arg Ser Asp Ser Gly Pro Thr Thr Ser Phe 
            100                 105                 110         


Glu Ser Ala Ala Cys Pro Gly Trp Phe Leu Cys Thr Ala Met Glu Ala 
        115                 120                 125             


Asp Gln Pro Val Ser Leu Thr Asn Met Pro Asp Glu Gly Val Met Val 
    130                 135                 140                 


Thr Lys Phe Tyr Phe Gln Glu Asp Glu Gly Gly Gly Gly Ser Gly Gly 
145                 150                 155                 160 


Gly Gly Ser Pro Val Pro Pro Thr Gly Asp Ser Glu Ala Thr Pro Val 
                165                 170                 175     


Pro Pro Thr Gly Asp Ser Glu Thr Ala Pro Val Pro Pro Thr Gly Asp 
            180                 185                 190         


Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro 
        195                 200                 205             


Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly 
    210                 215                 220                 


Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro 
225                 230                 235                 240 


Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr 
                245                 250                 255     


Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala 
            260                 265                 270         


Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro 
        275                 280                 285             


Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Gly 
    290                 295                 300                 


Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro 
305                 310                 315                 320 


Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser 
                325                 330                 335     


Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val 
            340                 345                 350         


Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp 
        355                 360                 365             


Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro 
    370                 375                 380                 


Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly 
385                 390                 395                 400 


Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro 
                405                 410                 415     


Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr 
            420                 425                 430         


Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala 
        435                 440                 445             


Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro 
    450                 455                 460                 


Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Gly 
465                 470                 475                 480 


Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro 
                485                 490                 495     


Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser 
            500                 505                 510         


Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val 
        515                 520                 525             


Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp 
    530                 535                 540                 


Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro 
545                 550                 555                 560 


Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly 
                565                 570                 575     


Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro 
            580                 585                 590         


Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr 
        595                 600                 605             


Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala 
    610                 615                 620                 


Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro 
625                 630                 635                 640 


Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Gly 
                645                 650                 655     


Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro 
            660                 665                 670         


Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser 
        675                 680                 685             


Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val 
    690                 695                 700                 


Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp 
705                 710                 715                 720 


Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro 
                725                 730                 735     


Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly 
            740                 745                 750         


Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro 
        755                 760                 765             


Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr 
    770                 775                 780                 


Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala 
785                 790                 795                 800 


Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro 
                805                 810                 815     


Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Gly 
            820                 825                 830         


Ala Pro Pro Val Pro Pro Thr Gly Asp Ala Gly Pro Pro Pro Val Pro 
        835                 840                 845             


Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser 
    850                 855                 860                 


Gly Ala Pro Pro Val Thr Pro Thr Gly Asp Ser Glu Thr Ala Pro Val 
865                 870                 875                 880 


Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp 
                885                 890                 895     


Ser Glu Ala Ala Pro Val Pro Pro Thr Asp Asp Ser Lys Glu Ala Gly 
            900                 905                 910         


Ser 
    


<210>  47
<211>  913
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  M-IL1RA-G4SG4S-BSSL CTD (68, v2)-GS

<400>  47

Met Arg Pro Ser Gly Arg Lys Ser Ser Lys Met Gln Ala Phe Arg Ile 
1               5                   10                  15      


Trp Asp Val Asn Gln Lys Thr Phe Tyr Leu Arg Asn Asn Gln Leu Val 
            20                  25                  30          


Ala Gly Tyr Leu Gln Gly Pro Asn Val Asn Leu Glu Glu Lys Ile Asp 
        35                  40                  45              


Val Val Pro Ile Glu Pro His Ala Leu Phe Leu Gly Ile His Gly Gly 
    50                  55                  60                  


Lys Met Cys Leu Ser Cys Val Lys Ser Gly Asp Glu Thr Arg Leu Gln 
65                  70                  75                  80  


Leu Glu Ala Val Asn Ile Thr Asp Leu Ser Glu Asn Arg Lys Gln Asp 
                85                  90                  95      


Lys Arg Phe Ala Phe Ile Arg Ser Asp Ser Gly Pro Thr Thr Ser Phe 
            100                 105                 110         


Glu Ser Ala Ala Cys Pro Gly Trp Phe Leu Cys Thr Ala Met Glu Ala 
        115                 120                 125             


Asp Gln Pro Val Ser Leu Thr Asn Met Pro Asp Glu Gly Val Met Val 
    130                 135                 140                 


Thr Lys Phe Tyr Phe Gln Glu Asp Glu Gly Gly Gly Gly Ser Gly Gly 
145                 150                 155                 160 


Gly Gly Ser Pro Val Pro Pro Thr Gly Asp Ser Glu Ala Thr Pro Val 
                165                 170                 175     


Pro Pro Thr Gly Asp Ser Glu Thr Ala Pro Val Pro Pro Thr Gly Asp 
            180                 185                 190         


Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro 
        195                 200                 205             


Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly 
    210                 215                 220                 


Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro 
225                 230                 235                 240 


Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr 
                245                 250                 255     


Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala 
            260                 265                 270         


Pro Pro Val Pro Pro Thr Gly Asp Ala Gly Pro Pro Pro Val Pro Pro 
        275                 280                 285             


Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Gly 
    290                 295                 300                 


Ala Pro Pro Val Thr Pro Thr Gly Asp Ser Glu Thr Ala Pro Val Pro 
305                 310                 315                 320 


Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser 
                325                 330                 335     


Glu Ala Ala Pro Val Pro Pro Thr Asp Asp Ser Lys Glu Ala Pro Val 
            340                 345                 350         


Pro Pro Thr Gly Asp Ser Glu Ala Thr Pro Val Pro Pro Thr Gly Asp 
        355                 360                 365             


Ser Glu Thr Ala Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro 
    370                 375                 380                 


Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly 
385                 390                 395                 400 


Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro 
                405                 410                 415     


Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr 
            420                 425                 430         


Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala 
        435                 440                 445             


Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro 
    450                 455                 460                 


Thr Gly Asp Ala Gly Pro Pro Pro Val Pro Pro Thr Gly Asp Ser Gly 
465                 470                 475                 480 


Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Thr 
                485                 490                 495     


Pro Thr Gly Asp Ser Glu Thr Ala Pro Val Pro Pro Thr Gly Asp Ser 
            500                 505                 510         


Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Glu Ala Ala Pro Val 
        515                 520                 525             


Pro Pro Thr Asp Asp Ser Lys Glu Ala Pro Val Pro Pro Thr Gly Asp 
    530                 535                 540                 


Ser Glu Ala Thr Pro Val Pro Pro Thr Gly Asp Ser Glu Thr Ala Pro 
545                 550                 555                 560 


Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly 
                565                 570                 575     


Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro 
            580                 585                 590         


Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr 
        595                 600                 605             


Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala 
    610                 615                 620                 


Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro 
625                 630                 635                 640 


Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ala Gly 
                645                 650                 655     


Pro Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro 
            660                 665                 670         


Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Thr Pro Thr Gly Asp Ser 
        675                 680                 685             


Glu Thr Ala Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val 
    690                 695                 700                 


Pro Pro Thr Gly Asp Ser Glu Ala Ala Pro Val Pro Pro Thr Asp Asp 
705                 710                 715                 720 


Ser Lys Glu Ala Pro Val Pro Pro Thr Gly Asp Ser Glu Ala Thr Pro 
                725                 730                 735     


Val Pro Pro Thr Gly Asp Ser Glu Thr Ala Pro Val Pro Pro Thr Gly 
            740                 745                 750         


Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro 
        755                 760                 765             


Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr 
    770                 775                 780                 


Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala 
785                 790                 795                 800 


Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro 
                805                 810                 815     


Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Gly 
            820                 825                 830         


Ala Pro Pro Val Pro Pro Thr Gly Asp Ala Gly Pro Pro Pro Val Pro 
        835                 840                 845             


Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser 
    850                 855                 860                 


Gly Ala Pro Pro Val Thr Pro Thr Gly Asp Ser Glu Thr Ala Pro Val 
865                 870                 875                 880 


Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp 
                885                 890                 895     


Ser Glu Ala Ala Pro Val Pro Pro Thr Asp Asp Ser Lys Glu Ala Gly 
            900                 905                 910         


Ser 
    


<210>  48
<211>  701
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  M-IL1RA-G4SG4S-BSSL CTD (34, v1)-GSG4SG4S-IL1RA

<400>  48

Met Arg Pro Ser Gly Arg Lys Ser Ser Lys Met Gln Ala Phe Arg Ile 
1               5                   10                  15      


Trp Asp Val Asn Gln Lys Thr Phe Tyr Leu Arg Asn Asn Gln Leu Val 
            20                  25                  30          


Ala Gly Tyr Leu Gln Gly Pro Asn Val Asn Leu Glu Glu Lys Ile Asp 
        35                  40                  45              


Val Val Pro Ile Glu Pro His Ala Leu Phe Leu Gly Ile His Gly Gly 
    50                  55                  60                  


Lys Met Cys Leu Ser Cys Val Lys Ser Gly Asp Glu Thr Arg Leu Gln 
65                  70                  75                  80  


Leu Glu Ala Val Asn Ile Thr Asp Leu Ser Glu Asn Arg Lys Gln Asp 
                85                  90                  95      


Lys Arg Phe Ala Phe Ile Arg Ser Asp Ser Gly Pro Thr Thr Ser Phe 
            100                 105                 110         


Glu Ser Ala Ala Cys Pro Gly Trp Phe Leu Cys Thr Ala Met Glu Ala 
        115                 120                 125             


Asp Gln Pro Val Ser Leu Thr Asn Met Pro Asp Glu Gly Val Met Val 
    130                 135                 140                 


Thr Lys Phe Tyr Phe Gln Glu Asp Glu Gly Gly Gly Gly Ser Gly Gly 
145                 150                 155                 160 


Gly Gly Ser Pro Val Pro Pro Thr Gly Asp Ser Glu Ala Thr Pro Val 
                165                 170                 175     


Pro Pro Thr Gly Asp Ser Glu Thr Ala Pro Val Pro Pro Thr Gly Asp 
            180                 185                 190         


Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro 
        195                 200                 205             


Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly 
    210                 215                 220                 


Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro 
225                 230                 235                 240 


Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr 
                245                 250                 255     


Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala 
            260                 265                 270         


Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro 
        275                 280                 285             


Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Gly 
    290                 295                 300                 


Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro 
305                 310                 315                 320 


Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser 
                325                 330                 335     


Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val 
            340                 345                 350         


Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp 
        355                 360                 365             


Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro 
    370                 375                 380                 


Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly 
385                 390                 395                 400 


Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro 
                405                 410                 415     


Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr 
            420                 425                 430         


Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala 
        435                 440                 445             


Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro 
    450                 455                 460                 


Thr Gly Asp Ala Gly Pro Pro Pro Val Pro Pro Thr Gly Asp Ser Gly 
465                 470                 475                 480 


Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Thr 
                485                 490                 495     


Pro Thr Gly Asp Ser Glu Thr Ala Pro Val Pro Pro Thr Gly Asp Ser 
            500                 505                 510         


Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Glu Ala Ala Pro Val 
        515                 520                 525             


Pro Pro Thr Asp Asp Ser Lys Glu Ala Gly Ser Gly Gly Gly Gly Ser 
    530                 535                 540                 


Gly Gly Gly Gly Ser Arg Pro Ser Gly Arg Lys Ser Ser Lys Met Gln 
545                 550                 555                 560 


Ala Phe Arg Ile Trp Asp Val Asn Gln Lys Thr Phe Tyr Leu Arg Asn 
                565                 570                 575     


Asn Gln Leu Val Ala Gly Tyr Leu Gln Gly Pro Asn Val Asn Leu Glu 
            580                 585                 590         


Glu Lys Ile Asp Val Val Pro Ile Glu Pro His Ala Leu Phe Leu Gly 
        595                 600                 605             


Ile His Gly Gly Lys Met Cys Leu Ser Cys Val Lys Ser Gly Asp Glu 
    610                 615                 620                 


Thr Arg Leu Gln Leu Glu Ala Val Asn Ile Thr Asp Leu Ser Glu Asn 
625                 630                 635                 640 


Arg Lys Gln Asp Lys Arg Phe Ala Phe Ile Arg Ser Asp Ser Gly Pro 
                645                 650                 655     


Thr Thr Ser Phe Glu Ser Ala Ala Cys Pro Gly Trp Phe Leu Cys Thr 
            660                 665                 670         


Ala Met Glu Ala Asp Gln Pro Val Ser Leu Thr Asn Met Pro Asp Glu 
        675                 680                 685             


Gly Val Met Val Thr Lys Phe Tyr Phe Gln Glu Asp Glu 
    690                 695                 700     


<210>  49
<211>  701
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  M-IL1RA-G4SG4S-BSSL CTD (34, V2)-GSG4SG4S-IL1RA

<400>  49

Met Arg Pro Ser Gly Arg Lys Ser Ser Lys Met Gln Ala Phe Arg Ile 
1               5                   10                  15      


Trp Asp Val Asn Gln Lys Thr Phe Tyr Leu Arg Asn Asn Gln Leu Val 
            20                  25                  30          


Ala Gly Tyr Leu Gln Gly Pro Asn Val Asn Leu Glu Glu Lys Ile Asp 
        35                  40                  45              


Val Val Pro Ile Glu Pro His Ala Leu Phe Leu Gly Ile His Gly Gly 
    50                  55                  60                  


Lys Met Cys Leu Ser Cys Val Lys Ser Gly Asp Glu Thr Arg Leu Gln 
65                  70                  75                  80  


Leu Glu Ala Val Asn Ile Thr Asp Leu Ser Glu Asn Arg Lys Gln Asp 
                85                  90                  95      


Lys Arg Phe Ala Phe Ile Arg Ser Asp Ser Gly Pro Thr Thr Ser Phe 
            100                 105                 110         


Glu Ser Ala Ala Cys Pro Gly Trp Phe Leu Cys Thr Ala Met Glu Ala 
        115                 120                 125             


Asp Gln Pro Val Ser Leu Thr Asn Met Pro Asp Glu Gly Val Met Val 
    130                 135                 140                 


Thr Lys Phe Tyr Phe Gln Glu Asp Glu Gly Gly Gly Gly Ser Gly Gly 
145                 150                 155                 160 


Gly Gly Ser Pro Val Pro Pro Thr Gly Asp Ser Glu Ala Thr Pro Val 
                165                 170                 175     


Pro Pro Thr Gly Asp Ser Glu Thr Ala Pro Val Pro Pro Thr Gly Asp 
            180                 185                 190         


Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro 
        195                 200                 205             


Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly 
    210                 215                 220                 


Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro 
225                 230                 235                 240 


Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr 
                245                 250                 255     


Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala 
            260                 265                 270         


Pro Pro Val Pro Pro Thr Gly Asp Ala Gly Pro Pro Pro Val Pro Pro 
        275                 280                 285             


Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Gly 
    290                 295                 300                 


Ala Pro Pro Val Thr Pro Thr Gly Asp Ser Glu Thr Ala Pro Val Pro 
305                 310                 315                 320 


Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser 
                325                 330                 335     


Glu Ala Ala Pro Val Pro Pro Thr Asp Asp Ser Lys Glu Ala Pro Val 
            340                 345                 350         


Pro Pro Thr Gly Asp Ser Glu Ala Thr Pro Val Pro Pro Thr Gly Asp 
        355                 360                 365             


Ser Glu Thr Ala Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro 
    370                 375                 380                 


Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly 
385                 390                 395                 400 


Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro 
                405                 410                 415     


Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr 
            420                 425                 430         


Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala 
        435                 440                 445             


Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro 
    450                 455                 460                 


Thr Gly Asp Ala Gly Pro Pro Pro Val Pro Pro Thr Gly Asp Ser Gly 
465                 470                 475                 480 


Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Thr 
                485                 490                 495     


Pro Thr Gly Asp Ser Glu Thr Ala Pro Val Pro Pro Thr Gly Asp Ser 
            500                 505                 510         


Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Glu Ala Ala Pro Val 
        515                 520                 525             


Pro Pro Thr Asp Asp Ser Lys Glu Ala Gly Ser Gly Gly Gly Gly Ser 
    530                 535                 540                 


Gly Gly Gly Gly Ser Arg Pro Ser Gly Arg Lys Ser Ser Lys Met Gln 
545                 550                 555                 560 


Ala Phe Arg Ile Trp Asp Val Asn Gln Lys Thr Phe Tyr Leu Arg Asn 
                565                 570                 575     


Asn Gln Leu Val Ala Gly Tyr Leu Gln Gly Pro Asn Val Asn Leu Glu 
            580                 585                 590         


Glu Lys Ile Asp Val Val Pro Ile Glu Pro His Ala Leu Phe Leu Gly 
        595                 600                 605             


Ile His Gly Gly Lys Met Cys Leu Ser Cys Val Lys Ser Gly Asp Glu 
    610                 615                 620                 


Thr Arg Leu Gln Leu Glu Ala Val Asn Ile Thr Asp Leu Ser Glu Asn 
625                 630                 635                 640 


Arg Lys Gln Asp Lys Arg Phe Ala Phe Ile Arg Ser Asp Ser Gly Pro 
                645                 650                 655     


Thr Thr Ser Phe Glu Ser Ala Ala Cys Pro Gly Trp Phe Leu Cys Thr 
            660                 665                 670         


Ala Met Glu Ala Asp Gln Pro Val Ser Leu Thr Asn Met Pro Asp Glu 
        675                 680                 685             


Gly Val Met Val Thr Lys Phe Tyr Phe Gln Glu Asp Glu 
    690                 695                 700     


<210>  50
<211>  58
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Z06175(N52S, D53E)

<400>  50

Ala Glu Ala Lys Tyr Ala Lys Glu Val Leu Glu Ala Trp Asp Glu Ile 
1               5                   10                  15      


Asp Arg Leu Pro Asn Leu Thr Ile Glu Gln Trp Leu Ala Phe Ile Asn 
            20                  25                  30          


Lys Leu Asp Asp Asp Pro Ser Gln Ser Ser Glu Leu Leu Ser Glu Ala 
        35                  40                  45              


Lys Lys Leu Ser Glu Ser Gln Ala Pro Lys 
    50                  55              


<210>  51
<211>  59
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Z06175(bb1)+C59

<400>  51

Ala Glu Ala Lys Tyr Ala Lys Glu Val Leu Glu Ala Trp Asp Glu Ile 
1               5                   10                  15      


Asp Arg Leu Pro Asn Leu Thr Ile Glu Gln Trp Leu Ala Phe Ile Asn 
            20                  25                  30          


Lys Leu Asp Asp Asp Pro Ser Gln Ser Ser Glu Leu Leu Ser Glu Ala 
        35                  40                  45              


Lys Lys Leu Ser Glu Ser Gln Ala Pro Lys Cys 
    50                  55                  


<210>  52
<211>  55
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GLP2 BSSL CTD 22 aa

<400>  52

His Ala Asp Gly Ser Phe Ser Asp Glu Met Asn Thr Ile Leu Asp Asn 
1               5                   10                  15      


Leu Ala Ala Arg Asp Phe Ile Asn Trp Leu Ile Gln Thr Lys Ile Thr 
            20                  25                  30          


Asp Pro Val Pro Pro Thr Gly Asp Ser Glu Ala Thr Pro Val Pro Pro 
        35                  40                  45              


Thr Gly Asp Ser Glu Thr Ala 
    50                  55  


<210>  53
<211>  44
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GLP2 BSSL CTD 11 aa

<400>  53

His Ala Asp Gly Ser Phe Ser Asp Glu Met Asn Thr Ile Leu Asp Asn 
1               5                   10                  15      


Leu Ala Ala Arg Asp Phe Ile Asn Trp Leu Ile Gln Thr Lys Ile Thr 
            20                  25                  30          


Asp Pro Val Pro Pro Thr Gly Asp Ser Glu Ala Thr 
        35                  40                  


<210>  54
<211>  53
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GLP1(7-37) BSSL CTD 22 aa

<400>  54

His Ala Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly Arg Gly Pro 
            20                  25                  30          


Val Pro Pro Thr Gly Asp Ser Glu Ala Thr Pro Val Pro Pro Thr Gly 
        35                  40                  45              


Asp Ser Glu Thr Ala 
    50              


<210>  55
<211>  31
<212>  PRT
<213>  Homo sapiens

<400>  55

His Ala Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly Arg Gly 
            20                  25                  30      


<210>  56
<211>  33
<212>  PRT
<213>  Homo sapiens

<400>  56

His Ala Asp Gly Ser Phe Ser Asp Glu Met Asn Thr Ile Leu Asp Asn 
1               5                   10                  15      


Leu Ala Ala Arg Asp Phe Ile Asn Trp Leu Ile Gln Thr Lys Ile Thr 
            20                  25                  30          


Asp 
    


<210>  57
<211>  187
<212>  PRT
<213>  Homo sapiens

<400>  57

Pro Val Pro Pro Thr Gly Asp Ser Glu Ala Thr Pro Val Pro Pro Thr 
1               5                   10                  15      


Gly Asp Ser Glu Thr Ala Pro Val Pro Pro Thr Gly Asp Ser Gly Ala 
            20                  25                  30          


Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro 
        35                  40                  45              


Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Gly 
    50                  55                  60                  


Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro 
65                  70                  75                  80  


Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser 
                85                  90                  95      


Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val 
            100                 105                 110         


Pro Pro Thr Gly Asp Ala Gly Pro Pro Pro Val Pro Pro Thr Gly Asp 
        115                 120                 125             


Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro 
    130                 135                 140                 


Val Thr Pro Thr Gly Asp Ser Glu Thr Ala Pro Val Pro Pro Thr Gly 
145                 150                 155                 160 


Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Glu Ala Ala 
                165                 170                 175     


Pro Val Pro Pro Thr Asp Asp Ser Lys Glu Ala 
            180                 185         


<210>  58
<211>  187
<212>  PRT
<213>  Homo sapiens

<400>  58

Pro Val Pro Pro Thr Gly Asp Ser Glu Ala Thr Pro Val Pro Pro Thr 
1               5                   10                  15      


Gly Asp Ser Glu Thr Ala Pro Val Pro Pro Thr Gly Asp Ser Gly Ala 
            20                  25                  30          


Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro 
        35                  40                  45              


Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Gly 
    50                  55                  60                  


Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro 
65                  70                  75                  80  


Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser 
                85                  90                  95      


Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val 
            100                 105                 110         


Pro Pro Thr Gly Asp Ala Gly Pro Pro Pro Val Pro Pro Thr Gly Asp 
        115                 120                 125             


Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro 
    130                 135                 140                 


Val Thr Pro Thr Gly Asp Ser Glu Thr Ala Pro Val Pro Pro Thr Gly 
145                 150                 155                 160 


Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Glu Ala Ala 
                165                 170                 175     


Pro Val Pro Pro Thr Asp Asp Ser Lys Glu Ala 
            180                 185         


<210>  59
<211>  176
<212>  PRT
<213>  Homo sapiens

<400>  59

Pro Val Pro Pro Thr Gly Asp Ser Glu Ala Thr Pro Val Pro Pro Thr 
1               5                   10                  15      


Gly Asp Ser Glu Thr Ala Pro Val Pro Pro Thr Gly Asp Ser Gly Ala 
            20                  25                  30          


Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro 
        35                  40                  45              


Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Gly 
    50                  55                  60                  


Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro 
65                  70                  75                  80  


Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser 
                85                  90                  95      


Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ala Gly Pro Pro Pro Val 
            100                 105                 110         


Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp 
        115                 120                 125             


Ser Gly Ala Pro Pro Val Thr Pro Thr Gly Asp Ser Glu Thr Ala Pro 
    130                 135                 140                 


Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly 
145                 150                 155                 160 


Asp Ser Glu Ala Ala Pro Val Pro Pro Thr Asp Asp Ser Lys Glu Ala 
                165                 170                 175     


<210>  60
<211>  176
<212>  PRT
<213>  Homo sapiens

<400>  60

Pro Val Pro Pro Thr Gly Asp Ser Glu Ala Thr Pro Val Pro Pro Thr 
1               5                   10                  15      


Gly Asp Ser Glu Thr Ala Pro Val Pro Pro Thr Gly Asp Ser Gly Ala 
            20                  25                  30          


Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro 
        35                  40                  45              


Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Gly 
    50                  55                  60                  


Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro 
65                  70                  75                  80  


Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser 
                85                  90                  95      


Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ala Gly Pro Pro Pro Val 
            100                 105                 110         


Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp 
        115                 120                 125             


Ser Gly Ala Pro Pro Val Thr Pro Thr Gly Asp Ser Glu Thr Ala Pro 
    130                 135                 140                 


Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly 
145                 150                 155                 160 


Asp Ser Glu Ala Ala Pro Val Pro Pro Thr Asp Asp Ser Lys Glu Ala 
                165                 170                 175     


<210>  61
<211>  154
<212>  PRT
<213>  Homo sapiens

<400>  61

Pro Val Pro Pro Thr Gly Asp Ser Glu Ala Thr Pro Val Pro Pro Thr 
1               5                   10                  15      


Gly Asp Ser Glu Thr Ala Pro Val Pro Pro Thr Gly Asp Ser Gly Ala 
            20                  25                  30          


Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro 
        35                  40                  45              


Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Gly 
    50                  55                  60                  


Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro 
65                  70                  75                  80  


Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser 
                85                  90                  95      


Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ala Gly Pro Pro Pro Val 
            100                 105                 110         


Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp 
        115                 120                 125             


Ser Gly Ala Pro Pro Val Thr Pro Thr Gly Asp Ser Glu Thr Ala Pro 
    130                 135                 140                 


Val Pro Pro Thr Gly Asp Ser Gly Ala Pro 
145                 150                 


<210>  62
<211>  66
<212>  PRT
<213>  Homo sapiens

<400>  62

Pro Val Pro Pro Thr Gly Asp Ser Glu Ala Thr Pro Val Pro Pro Thr 
1               5                   10                  15      


Gly Asp Ser Glu Thr Ala Pro Val Pro Pro Thr Gly Asp Ser Gly Ala 
            20                  25                  30          


Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro 
        35                  40                  45              


Thr Gly Asp Ser Glu Ala Ala Pro Val Pro Pro Thr Gly Asp Ser Lys 
    50                  55                  60                  


Glu Ala 
65      


<210>  63
<211>  154
<212>  PRT
<213>  Homo sapiens

<400>  63

Pro Val Pro Pro Thr Gly Asp Ser Glu Ala Thr Pro Val Pro Pro Thr 
1               5                   10                  15      


Gly Asp Ser Glu Thr Ala Pro Val Pro Pro Thr Gly Asp Ser Gly Ala 
            20                  25                  30          


Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro 
        35                  40                  45              


Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Gly 
    50                  55                  60                  


Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro 
65                  70                  75                  80  


Pro Thr Gly Asp Ala Gly Pro Pro Pro Val Pro Pro Thr Gly Asp Ser 
                85                  90                  95      


Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val 
            100                 105                 110         


Thr Pro Thr Gly Asp Ser Glu Thr Ala Pro Val Pro Pro Thr Gly Asp 
        115                 120                 125             


Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Glu Ala Ala Pro 
    130                 135                 140                 


Val Pro Pro Thr Asp Asp Ser Lys Glu Ala 
145                 150                 


<210>  64
<211>  176
<212>  PRT
<213>  Homo sapiens

<400>  64

Pro Val Pro Pro Thr Gly Asp Ser Glu Ala Thr Pro Val Pro Pro Thr 
1               5                   10                  15      


Gly Asp Ser Glu Thr Ala Pro Val Pro Pro Thr Gly Asp Ser Gly Ala 
            20                  25                  30          


Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro 
        35                  40                  45              


Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Gly 
    50                  55                  60                  


Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro 
65                  70                  75                  80  


Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser 
                85                  90                  95      


Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ala Gly Pro Pro Pro Val 
            100                 105                 110         


Pro Pro Thr Gly Asp Ser Gly Pro Pro Pro Val Pro Pro Thr Gly Asp 
        115                 120                 125             


Ser Gly Ala Pro Pro Val Thr Pro Thr Gly Asp Ser Glu Thr Ala Pro 
    130                 135                 140                 


Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly 
145                 150                 155                 160 


Asp Ser Glu Ala Ala Pro Val Pro Pro Thr Asp Asp Ser Lys Glu Ala 
                165                 170                 175     


<210>  65
<211>  110
<212>  PRT
<213>  Homo sapiens

<400>  65

Pro Val Pro Pro Thr Gly Asp Ser Glu Ala Thr Pro Val Pro Pro Thr 
1               5                   10                  15      


Gly Asp Ser Glu Thr Ala Pro Val Pro Pro Thr Gly Asp Ser Gly Ala 
            20                  25                  30          


Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro 
        35                  40                  45              


Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Gly 
    50                  55                  60                  


Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro 
65                  70                  75                  80  


Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser 
                85                  90                  95      


Gly Ala Pro Pro Val Pro Pro Thr Asp Asp Ser Lys Glu Ala 
            100                 105                 110 


<210>  66
<211>  77
<212>  PRT
<213>  Homo sapiens

<400>  66

Pro Val Pro Pro Thr Gly Asp Ser Glu Ala Thr Pro Val Pro Pro Thr 
1               5                   10                  15      


Gly Asp Ser Glu Thr Ala Pro Val Pro Pro Thr Gly Asp Ser Gly Ala 
            20                  25                  30          


Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro 
        35                  40                  45              


Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Gly 
    50                  55                  60                  


Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro 
65                  70                  75          


<210>  67
<211>  226
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ruplizumab Fab (hu5c8) HC

<400>  67

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Ile Phe Thr Ser Tyr 
            20                  25                  30          


Tyr Met Tyr Trp Val Lys Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Asn Pro Ser Asn Gly Asp Thr Asn Phe Asn Glu Lys Phe 
    50                  55                  60                  


Lys Ser Lys Ala Thr Leu Thr Val Asp Lys Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Ser Asp Gly Arg Asn Asp Met Asp Ser Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
        115                 120                 125             


Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly 
    130                 135                 140                 


Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
145                 150                 155                 160 


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
                165                 170                 175     


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
            180                 185                 190         


Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser 
        195                 200                 205             


Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr 
    210                 215                 220                 


His Thr 
225     


<210>  68
<211>  218
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ruplizumab Fab (hu5c8) LC

<400>  68

Asp Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Ser Cys Arg Ala Ser Gln Arg Val Ser Ser Ser 
            20                  25                  30          


Thr Tyr Ser Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Lys Tyr Ala Ser Asn Leu Glu Ser Gly Val Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  


Ser Val Glu Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln His Ser Trp 
                85                  90                  95      


Glu Ile Pro Pro Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105                 110         


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
        115                 120                 125             


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
    130                 135                 140                 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
145                 150                 155                 160 


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
                165                 170                 175     


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
            180                 185                 190         


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
        195                 200                 205             


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215             


<210>  69
<211>  423
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ruplizumab Fab (hu5c8) HC (17 units)

<400>  69

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Ile Phe Thr Ser Tyr 
            20                  25                  30          


Tyr Met Tyr Trp Val Lys Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Asn Pro Ser Asn Gly Asp Thr Asn Phe Asn Glu Lys Phe 
    50                  55                  60                  


Lys Ser Lys Ala Thr Leu Thr Val Asp Lys Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Ser Asp Gly Arg Asn Asp Met Asp Ser Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
        115                 120                 125             


Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly 
    130                 135                 140                 


Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
145                 150                 155                 160 


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
                165                 170                 175     


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
            180                 185                 190         


Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser 
        195                 200                 205             


Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr 
    210                 215                 220                 


His Thr Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Pro Val Pro Pro 
225                 230                 235                 240 


Thr Gly Asp Ser Glu Ala Thr Pro Val Pro Pro Thr Gly Asp Ser Glu 
                245                 250                 255     


Thr Ala Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro 
            260                 265                 270         


Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser 
        275                 280                 285             


Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val 
    290                 295                 300                 


Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp 
305                 310                 315                 320 


Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro 
                325                 330                 335     


Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly 
            340                 345                 350         


Asp Ala Gly Pro Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro 
        355                 360                 365             


Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Thr Pro Thr 
    370                 375                 380                 


Gly Asp Ser Glu Thr Ala Pro Val Pro Pro Thr Gly Asp Ser Gly Ala 
385                 390                 395                 400 


Pro Pro Val Pro Pro Thr Gly Asp Ser Glu Ala Ala Pro Val Pro Pro 
                405                 410                 415     


Thr Asp Asp Ser Lys Glu Ala 
            420             


<210>  70
<211>  415
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ruplizumab Fab (hu5c8) LC (17 units)

<400>  70

Asp Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Ser Cys Arg Ala Ser Gln Arg Val Ser Ser Ser 
            20                  25                  30          


Thr Tyr Ser Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Lys Tyr Ala Ser Asn Leu Glu Ser Gly Val Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  


Ser Val Glu Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln His Ser Trp 
                85                  90                  95      


Glu Ile Pro Pro Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105                 110         


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
        115                 120                 125             


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
    130                 135                 140                 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
145                 150                 155                 160 


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
                165                 170                 175     


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
            180                 185                 190         


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
        195                 200                 205             


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys Gly Gly Gly Gly Ser Gly 
    210                 215                 220                 


Gly Gly Gly Ser Pro Val Pro Pro Thr Gly Asp Ser Glu Ala Thr Pro 
225                 230                 235                 240 


Val Pro Pro Thr Gly Asp Ser Glu Thr Ala Pro Val Pro Pro Thr Gly 
                245                 250                 255     


Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro 
            260                 265                 270         


Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr 
        275                 280                 285             


Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala 
    290                 295                 300                 


Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro 
305                 310                 315                 320 


Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Gly 
                325                 330                 335     


Ala Pro Pro Val Pro Pro Thr Gly Asp Ala Gly Pro Pro Pro Val Pro 
            340                 345                 350         


Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser 
        355                 360                 365             


Gly Ala Pro Pro Val Thr Pro Thr Gly Asp Ser Glu Thr Ala Pro Val 
    370                 375                 380                 


Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp 
385                 390                 395                 400 


Ser Glu Ala Ala Pro Val Pro Pro Thr Asp Asp Ser Lys Glu Ala 
                405                 410                 415 


<210>  71
<211>  610
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ruplizumab Fab (hu5c8) HC (34 units)

<400>  71

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Ile Phe Thr Ser Tyr 
            20                  25                  30          


Tyr Met Tyr Trp Val Lys Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Asn Pro Ser Asn Gly Asp Thr Asn Phe Asn Glu Lys Phe 
    50                  55                  60                  


Lys Ser Lys Ala Thr Leu Thr Val Asp Lys Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Ser Asp Gly Arg Asn Asp Met Asp Ser Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
        115                 120                 125             


Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly 
    130                 135                 140                 


Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
145                 150                 155                 160 


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
                165                 170                 175     


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
            180                 185                 190         


Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser 
        195                 200                 205             


Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr 
    210                 215                 220                 


His Thr Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Pro Val Pro Pro 
225                 230                 235                 240 


Thr Gly Asp Ser Glu Ala Thr Pro Val Pro Pro Thr Gly Asp Ser Glu 
                245                 250                 255     


Thr Ala Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro 
            260                 265                 270         


Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser 
        275                 280                 285             


Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val 
    290                 295                 300                 


Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp 
305                 310                 315                 320 


Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro 
                325                 330                 335     


Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly 
            340                 345                 350         


Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro 
        355                 360                 365             


Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr 
    370                 375                 380                 


Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala 
385                 390                 395                 400 


Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro 
                405                 410                 415     


Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Gly 
            420                 425                 430         


Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro 
        435                 440                 445             


Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser 
    450                 455                 460                 


Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val 
465                 470                 475                 480 


Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp 
                485                 490                 495     


Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro 
            500                 505                 510         


Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly 
        515                 520                 525             


Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ala Gly Pro Pro 
    530                 535                 540                 


Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr 
545                 550                 555                 560 


Gly Asp Ser Gly Ala Pro Pro Val Thr Pro Thr Gly Asp Ser Glu Thr 
                565                 570                 575     


Ala Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro 
            580                 585                 590         


Thr Gly Asp Ser Glu Ala Ala Pro Val Pro Pro Thr Asp Asp Ser Lys 
        595                 600                 605             


Glu Ala 
    610 


<210>  72
<211>  602
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ruplizumab Fab (hu5c8) LC (34 units)

<400>  72

Asp Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Ser Cys Arg Ala Ser Gln Arg Val Ser Ser Ser 
            20                  25                  30          


Thr Tyr Ser Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Lys Tyr Ala Ser Asn Leu Glu Ser Gly Val Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  


Ser Val Glu Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln His Ser Trp 
                85                  90                  95      


Glu Ile Pro Pro Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105                 110         


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
        115                 120                 125             


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
    130                 135                 140                 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
145                 150                 155                 160 


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
                165                 170                 175     


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
            180                 185                 190         


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
        195                 200                 205             


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys Gly Gly Gly Gly Ser Gly 
    210                 215                 220                 


Gly Gly Gly Ser Pro Val Pro Pro Thr Gly Asp Ser Glu Ala Thr Pro 
225                 230                 235                 240 


Val Pro Pro Thr Gly Asp Ser Glu Thr Ala Pro Val Pro Pro Thr Gly 
                245                 250                 255     


Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro 
            260                 265                 270         


Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr 
        275                 280                 285             


Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala 
    290                 295                 300                 


Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro 
305                 310                 315                 320 


Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Gly 
                325                 330                 335     


Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro 
            340                 345                 350         


Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser 
        355                 360                 365             


Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val 
    370                 375                 380                 


Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp 
385                 390                 395                 400 


Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro 
                405                 410                 415     


Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly 
            420                 425                 430         


Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro 
        435                 440                 445             


Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr 
    450                 455                 460                 


Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala 
465                 470                 475                 480 


Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro 
                485                 490                 495     


Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Gly 
            500                 505                 510         


Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro 
        515                 520                 525             


Pro Thr Gly Asp Ala Gly Pro Pro Pro Val Pro Pro Thr Gly Asp Ser 
    530                 535                 540                 


Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val 
545                 550                 555                 560 


Thr Pro Thr Gly Asp Ser Glu Thr Ala Pro Val Pro Pro Thr Gly Asp 
                565                 570                 575     


Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Glu Ala Ala Pro 
            580                 585                 590         


Val Pro Pro Thr Asp Asp Ser Lys Glu Ala 
        595                 600         


<210>  73
<211>  797
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ruplizumab Fab (hu5c8) HC (51 units)

<400>  73

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Ile Phe Thr Ser Tyr 
            20                  25                  30          


Tyr Met Tyr Trp Val Lys Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Asn Pro Ser Asn Gly Asp Thr Asn Phe Asn Glu Lys Phe 
    50                  55                  60                  


Lys Ser Lys Ala Thr Leu Thr Val Asp Lys Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Ser Asp Gly Arg Asn Asp Met Asp Ser Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
        115                 120                 125             


Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly 
    130                 135                 140                 


Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
145                 150                 155                 160 


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
                165                 170                 175     


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
            180                 185                 190         


Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser 
        195                 200                 205             


Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr 
    210                 215                 220                 


His Thr Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Pro Val Pro Pro 
225                 230                 235                 240 


Thr Gly Asp Ser Glu Ala Thr Pro Val Pro Pro Thr Gly Asp Ser Glu 
                245                 250                 255     


Thr Ala Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro 
            260                 265                 270         


Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser 
        275                 280                 285             


Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val 
    290                 295                 300                 


Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp 
305                 310                 315                 320 


Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro 
                325                 330                 335     


Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly 
            340                 345                 350         


Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro 
        355                 360                 365             


Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr 
    370                 375                 380                 


Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala 
385                 390                 395                 400 


Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro 
                405                 410                 415     


Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Gly 
            420                 425                 430         


Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro 
        435                 440                 445             


Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser 
    450                 455                 460                 


Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val 
465                 470                 475                 480 


Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp 
                485                 490                 495     


Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro 
            500                 505                 510         


Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly 
        515                 520                 525             


Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro 
    530                 535                 540                 


Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr 
545                 550                 555                 560 


Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala 
                565                 570                 575     


Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro 
            580                 585                 590         


Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Gly 
        595                 600                 605             


Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro 
    610                 615                 620                 


Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser 
625                 630                 635                 640 


Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val 
                645                 650                 655     


Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp 
            660                 665                 670         


Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro 
        675                 680                 685             


Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly 
    690                 695                 700                 


Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro 
705                 710                 715                 720 


Pro Val Pro Pro Thr Gly Asp Ala Gly Pro Pro Pro Val Pro Pro Thr 
                725                 730                 735     


Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala 
            740                 745                 750         


Pro Pro Val Thr Pro Thr Gly Asp Ser Glu Thr Ala Pro Val Pro Pro 
        755                 760                 765             


Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Glu 
    770                 775                 780                 


Ala Ala Pro Val Pro Pro Thr Asp Asp Ser Lys Glu Ala 
785                 790                 795         


<210>  74
<211>  984
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ruplizumab Fab (hu5c8) (68x1 units)

<400>  74

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Ile Phe Thr Ser Tyr 
            20                  25                  30          


Tyr Met Tyr Trp Val Lys Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Asn Pro Ser Asn Gly Asp Thr Asn Phe Asn Glu Lys Phe 
    50                  55                  60                  


Lys Ser Lys Ala Thr Leu Thr Val Asp Lys Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Ser Asp Gly Arg Asn Asp Met Asp Ser Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
        115                 120                 125             


Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly 
    130                 135                 140                 


Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
145                 150                 155                 160 


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
                165                 170                 175     


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
            180                 185                 190         


Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser 
        195                 200                 205             


Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr 
    210                 215                 220                 


His Thr Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Pro Val Pro Pro 
225                 230                 235                 240 


Thr Gly Asp Ser Glu Ala Thr Pro Val Pro Pro Thr Gly Asp Ser Glu 
                245                 250                 255     


Thr Ala Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro 
            260                 265                 270         


Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser 
        275                 280                 285             


Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val 
    290                 295                 300                 


Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp 
305                 310                 315                 320 


Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro 
                325                 330                 335     


Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly 
            340                 345                 350         


Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro 
        355                 360                 365             


Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr 
    370                 375                 380                 


Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala 
385                 390                 395                 400 


Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro 
                405                 410                 415     


Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Gly 
            420                 425                 430         


Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro 
        435                 440                 445             


Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser 
    450                 455                 460                 


Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val 
465                 470                 475                 480 


Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp 
                485                 490                 495     


Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro 
            500                 505                 510         


Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly 
        515                 520                 525             


Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro 
    530                 535                 540                 


Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr 
545                 550                 555                 560 


Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala 
                565                 570                 575     


Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro 
            580                 585                 590         


Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Gly 
        595                 600                 605             


Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro 
    610                 615                 620                 


Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser 
625                 630                 635                 640 


Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val 
                645                 650                 655     


Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp 
            660                 665                 670         


Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro 
        675                 680                 685             


Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly 
    690                 695                 700                 


Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro 
705                 710                 715                 720 


Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr 
                725                 730                 735     


Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala 
            740                 745                 750         


Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro 
        755                 760                 765             


Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Gly 
    770                 775                 780                 


Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro 
785                 790                 795                 800 


Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser 
                805                 810                 815     


Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val 
            820                 825                 830         


Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp 
        835                 840                 845             


Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro 
    850                 855                 860                 


Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly 
865                 870                 875                 880 


Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro 
                885                 890                 895     


Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr 
            900                 905                 910         


Gly Asp Ala Gly Pro Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala 
        915                 920                 925             


Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Thr Pro 
    930                 935                 940                 


Thr Gly Asp Ser Glu Thr Ala Pro Val Pro Pro Thr Gly Asp Ser Gly 
945                 950                 955                 960 


Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Glu Ala Ala Pro Val Pro 
                965                 970                 975     


Pro Thr Asp Asp Ser Lys Glu Ala 
            980                 


<210>  75
<211>  448
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ruplizumab HC

<400>  75

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Ile Phe Thr Ser Tyr 
            20                  25                  30          


Tyr Met Tyr Trp Val Lys Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Asn Pro Ser Asn Gly Asp Thr Asn Phe Asn Glu Lys Phe 
    50                  55                  60                  


Lys Ser Lys Ala Thr Leu Thr Val Asp Lys Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Ser Asp Gly Arg Asn Asp Met Asp Ser Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
        115                 120                 125             


Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly 
    130                 135                 140                 


Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
145                 150                 155                 160 


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
                165                 170                 175     


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
            180                 185                 190         


Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser 
        195                 200                 205             


Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr 
    210                 215                 220                 


His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser 
225                 230                 235                 240 


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
                245                 250                 255     


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
            260                 265                 270         


Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
        275                 280                 285             


Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 
    290                 295                 300                 


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
305                 310                 315                 320 


Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 
                325                 330                 335     


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
            340                 345                 350         


Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys 
        355                 360                 365             


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
    370                 375                 380                 


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
385                 390                 395                 400 


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
                405                 410                 415     


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
            420                 425                 430         


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445             


<210>  76
<211>  228
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CD40L (sec) HC GS

<400>  76

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Ile Phe Thr Ser Tyr 
            20                  25                  30          


Tyr Met Tyr Trp Val Lys Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Asn Pro Ser Asn Gly Asp Thr Asn Phe Asn Glu Lys Phe 
    50                  55                  60                  


Lys Ser Lys Ala Thr Leu Thr Val Asp Lys Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Ser Asp Gly Arg Asn Asp Met Asp Ser Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
        115                 120                 125             


Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly 
    130                 135                 140                 


Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
145                 150                 155                 160 


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
                165                 170                 175     


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
            180                 185                 190         


Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser 
        195                 200                 205             


Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr 
    210                 215                 220                 


His Thr Gly Ser 
225             


<210>  77
<211>  229
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Met-anti-CD40L (cyt) HC - GS

<400>  77

Met Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Val Lys Pro Gly 
1               5                   10                  15      


Ala Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Ile Phe Thr Ser 
            20                  25                  30          


Tyr Tyr Met Tyr Trp Val Lys Gln Ala Pro Gly Gln Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly Glu Ile Asn Pro Ser Asn Gly Asp Thr Asn Phe Asn Glu Lys 
    50                  55                  60                  


Phe Lys Ser Lys Ala Thr Leu Thr Val Asp Lys Ser Ala Ser Thr Ala 
65                  70                  75                  80  


Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Thr Arg Ser Asp Gly Arg Asn Asp Met Asp Ser Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
        115                 120                 125             


Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu 
    130                 135                 140                 


Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
145                 150                 155                 160 


Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
                165                 170                 175     


Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
            180                 185                 190         


Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro 
        195                 200                 205             


Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys 
    210                 215                 220                 


Thr His Thr Gly Ser 
225                 


<210>  78
<211>  219
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Met-anti-CD40L (cyt) LC

<400>  78

Met Asp Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro 
1               5                   10                  15      


Gly Glu Arg Ala Thr Ile Ser Cys Arg Ala Ser Gln Arg Val Ser Ser 
            20                  25                  30          


Ser Thr Tyr Ser Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro 
        35                  40                  45              


Pro Lys Leu Leu Ile Lys Tyr Ala Ser Asn Leu Glu Ser Gly Val Pro 
    50                  55                  60                  


Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile 
65                  70                  75                  80  


Ser Ser Val Glu Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln His Ser 
                85                  90                  95      


Trp Glu Ile Pro Pro Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
        115                 120                 125             


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
    130                 135                 140                 


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
145                 150                 155                 160 


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
                165                 170                 175     


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
            180                 185                 190         


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
        195                 200                 205             


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 


<210>  79
<211>  257
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ruplizumab scFv (VL-VH)

<400>  79

Asp Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Ser Cys Arg Ala Ser Gln Arg Val Ser Ser Ser 
            20                  25                  30          


Thr Tyr Ser Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Lys Tyr Ala Ser Asn Leu Glu Ser Gly Val Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  


Ser Val Glu Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln His Ser Trp 
                85                  90                  95      


Glu Ile Pro Pro Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Gly 
            100                 105                 110         


Ala Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Ser Ser 
        115                 120                 125             


Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Val Lys Pro Gly Ala 
    130                 135                 140                 


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Ile Phe Thr Ser Tyr 
145                 150                 155                 160 


Tyr Met Tyr Trp Val Lys Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
                165                 170                 175     


Gly Glu Ile Asn Pro Ser Asn Gly Asp Thr Asn Phe Asn Glu Lys Phe 
            180                 185                 190         


Lys Ser Lys Ala Thr Leu Thr Val Asp Lys Ser Ala Ser Thr Ala Tyr 
        195                 200                 205             


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
    210                 215                 220                 


Thr Arg Ser Asp Gly Arg Asn Asp Met Asp Ser Trp Gly Gln Gly Thr 
225                 230                 235                 240 


Leu Val Thr Val Ser Ser Ala Ser Gly Gly Gly Gly Ser Glu Pro Glu 
                245                 250                 255     


Ala 
    


<210>  80
<211>  253
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ruplizumab scFv (VH-VL)

<400>  80

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Ile Phe Thr Ser Tyr 
            20                  25                  30          


Tyr Met Tyr Trp Val Lys Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Asn Pro Ser Asn Gly Asp Thr Asn Phe Asn Glu Lys Phe 
    50                  55                  60                  


Lys Ser Lys Ala Thr Leu Thr Val Asp Lys Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Ser Asp Gly Arg Asn Asp Met Asp Ser Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Ala Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Ser Asp Ile Val Leu Thr Gln Ser Pro Ala Thr Leu 
    130                 135                 140                 


Ser Val Ser Pro Gly Glu Arg Ala Thr Ile Ser Cys Arg Ala Ser Gln 
145                 150                 155                 160 


Arg Val Ser Ser Ser Thr Tyr Ser Tyr Met His Trp Tyr Gln Gln Lys 
                165                 170                 175     


Pro Gly Gln Pro Pro Lys Leu Leu Ile Lys Tyr Ala Ser Asn Leu Glu 
            180                 185                 190         


Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 
        195                 200                 205             


Thr Leu Thr Ile Ser Ser Val Glu Pro Glu Asp Phe Ala Thr Tyr Tyr 
    210                 215                 220                 


Cys Gln His Ser Trp Glu Ile Pro Pro Thr Phe Gly Gly Gly Thr Lys 
225                 230                 235                 240 


Leu Glu Ile Lys Gly Gly Gly Gly Ser Glu Pro Glu Ala 
                245                 250             


<210>  81
<211>  475
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ruplizumab-N297A-Avitag HC

<400>  81

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Ile Phe Thr Ser Tyr 
            20                  25                  30          


Tyr Met Tyr Trp Val Lys Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Asn Pro Ser Asn Gly Asp Thr Asn Phe Asn Glu Lys Phe 
    50                  55                  60                  


Lys Ser Lys Ala Thr Leu Thr Val Asp Lys Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Ser Asp Gly Arg Asn Asp Met Asp Ser Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
        115                 120                 125             


Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly 
    130                 135                 140                 


Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
145                 150                 155                 160 


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
                165                 170                 175     


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
            180                 185                 190         


Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser 
        195                 200                 205             


Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr 
    210                 215                 220                 


His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser 
225                 230                 235                 240 


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
                245                 250                 255     


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
            260                 265                 270         


Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
        275                 280                 285             


Lys Thr Lys Pro Arg Glu Glu Gln Tyr Ala Ser Thr Tyr Arg Val Val 
    290                 295                 300                 


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
305                 310                 315                 320 


Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 
                325                 330                 335     


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
            340                 345                 350         


Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys 
        355                 360                 365             


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
    370                 375                 380                 


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
385                 390                 395                 400 


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
                405                 410                 415     


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
            420                 425                 430         


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Leu Asn Asp Ile 
    450                 455                 460                 


Phe Glu Ala Gln Lys Ile Glu Trp His Gly Ser 
465                 470                 475 


<210>  82
<211>  604
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ruplizumab Fab E.coli OmpA HC 34 - GS

<400>  82

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Ile Phe Thr Ser Tyr 
            20                  25                  30          


Tyr Met Tyr Trp Val Lys Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Asn Pro Ser Asn Gly Asp Thr Asn Phe Asn Glu Lys Phe 
    50                  55                  60                  


Lys Ser Lys Ala Thr Leu Thr Val Asp Lys Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Ser Asp Gly Arg Asn Asp Met Asp Ser Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
        115                 120                 125             


Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly 
    130                 135                 140                 


Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
145                 150                 155                 160 


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
                165                 170                 175     


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
            180                 185                 190         


Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser 
        195                 200                 205             


Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr 
    210                 215                 220                 


His Thr Gly Ser Pro Val Pro Pro Thr Gly Asp Ser Glu Ala Thr Pro 
225                 230                 235                 240 


Val Pro Pro Thr Gly Asp Ser Glu Thr Ala Pro Val Pro Pro Thr Gly 
                245                 250                 255     


Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro 
            260                 265                 270         


Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr 
        275                 280                 285             


Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala 
    290                 295                 300                 


Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro 
305                 310                 315                 320 


Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Gly 
                325                 330                 335     


Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro 
            340                 345                 350         


Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser 
        355                 360                 365             


Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val 
    370                 375                 380                 


Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp 
385                 390                 395                 400 


Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro 
                405                 410                 415     


Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly 
            420                 425                 430         


Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro 
        435                 440                 445             


Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr 
    450                 455                 460                 


Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala 
465                 470                 475                 480 


Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro 
                485                 490                 495     


Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Gly 
            500                 505                 510         


Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro 
        515                 520                 525             


Pro Thr Gly Asp Ala Gly Pro Pro Pro Val Pro Pro Thr Gly Asp Ser 
    530                 535                 540                 


Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val 
545                 550                 555                 560 


Thr Pro Thr Gly Asp Ser Glu Thr Ala Pro Val Pro Pro Thr Gly Asp 
                565                 570                 575     


Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Glu Ala Ala Pro 
            580                 585                 590         


Val Pro Pro Thr Asp Asp Ser Lys Glu Ala Gly Ser 
        595                 600                 


<210>  83
<211>  605
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ruplizumab Fab E.coli cyt HC 34 - GS

<400>  83

Met Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Val Lys Pro Gly 
1               5                   10                  15      


Ala Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Ile Phe Thr Ser 
            20                  25                  30          


Tyr Tyr Met Tyr Trp Val Lys Gln Ala Pro Gly Gln Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly Glu Ile Asn Pro Ser Asn Gly Asp Thr Asn Phe Asn Glu Lys 
    50                  55                  60                  


Phe Lys Ser Lys Ala Thr Leu Thr Val Asp Lys Ser Ala Ser Thr Ala 
65                  70                  75                  80  


Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Thr Arg Ser Asp Gly Arg Asn Asp Met Asp Ser Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
        115                 120                 125             


Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu 
    130                 135                 140                 


Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
145                 150                 155                 160 


Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
                165                 170                 175     


Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
            180                 185                 190         


Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro 
        195                 200                 205             


Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys 
    210                 215                 220                 


Thr His Thr Gly Ser Pro Val Pro Pro Thr Gly Asp Ser Glu Ala Thr 
225                 230                 235                 240 


Pro Val Pro Pro Thr Gly Asp Ser Glu Thr Ala Pro Val Pro Pro Thr 
                245                 250                 255     


Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala 
            260                 265                 270         


Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro 
        275                 280                 285             


Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Gly 
    290                 295                 300                 


Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro 
305                 310                 315                 320 


Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser 
                325                 330                 335     


Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val 
            340                 345                 350         


Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp 
        355                 360                 365             


Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro 
    370                 375                 380                 


Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly 
385                 390                 395                 400 


Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro 
                405                 410                 415     


Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr 
            420                 425                 430         


Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala 
        435                 440                 445             


Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro 
    450                 455                 460                 


Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Gly 
465                 470                 475                 480 


Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro 
                485                 490                 495     


Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser 
            500                 505                 510         


Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val 
        515                 520                 525             


Pro Pro Thr Gly Asp Ala Gly Pro Pro Pro Val Pro Pro Thr Gly Asp 
    530                 535                 540                 


Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro 
545                 550                 555                 560 


Val Thr Pro Thr Gly Asp Ser Glu Thr Ala Pro Val Pro Pro Thr Gly 
                565                 570                 575     


Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Glu Ala Ala 
            580                 585                 590         


Pro Val Pro Pro Thr Asp Asp Ser Lys Glu Ala Gly Ser 
        595                 600                 605 


<210>  84
<211>  678
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ruplizumab Fab (hu5c8) HC

<400>  84
caggtgcagc tggtgcaatc tggcgctgag gttgtgaagc ctggcgcctc tgtgaagctg       60

tcctgtaaag cctccggcta catcttcacc agctactaca tgtactgggt caagcaggcc      120

cctggacagg gccttgagtg gatcggagag atcaaccctt ccaacggcga caccaacttc      180

aacgagaagt tcaagtccaa ggctaccctg accgtggaca agtctgcctc caccgcctac      240

atggaactgt ccagcctgag atctgaggac accgccgtgt actactgcac cagatccgac      300

ggccggaacg acatggattc ttggggacag ggcaccctgg tcaccgtgtc ctctgcttct      360

accaagggac ccagcgtgtt ccctctggct ccttccagca agtctacctc tggcggaaca      420

gctgctctgg gctgcctggt caaggactac tttcctgagc ctgtgaccgt gtcttggaac      480

tctggcgctc tgacatccgg cgtgcacacc tttccagctg tgctgcaatc ctccggcctg      540

tactctctgt cctccgtcgt gaccgtgcct tctagctctc tgggcaccca gacctacatc      600

tgcaatgtga accacaagcc ttccaacacc aaggtggaca agaaggtgga acccaagtcc      660

tgcgacaaga cccacaca                                                    678


<210>  85
<211>  2508
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ruplizumab Fab (hu5c8) HC-G4SX2-17 units

<400>  85
caggtgcagc tggtgcaatc tggcgctgag gttgtgaagc ctggcgcctc tgtgaagctg       60

tcctgtaaag cctccggcta catcttcacc agctactaca tgtactgggt caagcaggcc      120

cctggacagg gccttgagtg gatcggagag atcaaccctt ccaacggcga caccaacttc      180

aacgagaagt tcaagtccaa ggctaccctg accgtggaca agtctgcctc caccgcctac      240

atggaactgt ccagcctgag atctgaggac accgccgtgt actactgcac cagatccgac      300

ggccggaacg acatggattc ttggggacag ggcaccctgg tcaccgtgtc ctctgcttct      360

accaagggac ccagcgtgtt ccctctggct ccttccagca agtctacctc tggcggaaca      420

gctgctctgg gctgcctggt caaggactac tttcctgagc ctgtgaccgt gtcttggaac      480

tctggcgctc tgacatccgg cgtgcacacc tttccagctg tgctgcaatc ctccggcctg      540

tactctctgt cctccgtcgt gaccgtgcct tctagctctc tgggcaccca gacctacatc      600

tgcaatgtga accacaagcc ttccaacacc aaggtggaca agaaggtgga acccaagtcc      660

tgcgacaaga cccatacacc tgttcctcct actggcgact ctgaggctac acctgttcca      720

ccaaccggcg acagcgaaac agctcctgtg ccaccaacag gcgattctgg tgctcctcca      780

gtgcctccta ccggcgatag tggtgctcca cctgtgcctc caactggcga tagcggagca      840

cctccagttc cacctactgg cgattcaggt gcaccacctg ttcctccaac cggcgattct      900

ggcgcacctc ctgttccacc aactggcgac tccggcgctc cacctgtgcc acctaccggc      960

gactctgggg caccaccagt gcctccaaca ggcgacagtg gcgccccacc agtgccacct     1020

actggcgacg caggacctcc tcctgtgcct ccaaccggcg attcaggggc tccaccagtt     1080

ccaccaactg gcgatagtgg ggctcctcct gttactccta ccggggattc cgagactgcc     1140

cctgttccac ctaccggcga tagcggtgcc cctccagtgc caccaaccgg ggacagtgaa     1200

gctgctccag ttcctccaac agacgattcc aaagaggccc aggtgcagct ggtgcaatct     1260

ggcgctgagg ttgtgaagcc tggcgcctct gtgaagctgt cctgtaaagc ctccggctac     1320

atcttcacca gctactacat gtactgggtc aagcaggccc ctggacaggg ccttgagtgg     1380

atcggagaga tcaacccttc caacggcgac accaacttca acgagaagtt caagtccaag     1440

gctaccctga ccgtggacaa gtctgcctcc accgcctaca tggaactgtc cagcctgaga     1500

tctgaggaca ccgccgtgta ctactgcacc agatccgacg gccggaacga catggattct     1560

tggggacagg gcaccctggt caccgtgtcc tctgcttcta ccaagggacc cagcgtgttc     1620

cctctggctc cttccagcaa gtctacctct ggcggaacag ctgctctggg ctgcctggtc     1680

aaggactact ttcctgagcc tgtgaccgtg tcttggaact ctggcgctct gacatccggc     1740

gtgcacacct ttccagctgt gctgcaatcc tccggcctgt actctctgtc ctccgtcgtg     1800

accgtgcctt ctagctctct gggcacccag acctacatct gcaatgtgaa ccacaagcct     1860

tccaacacca aggtggacaa gaaggtggaa cccaagtcct gcgacaagac ccatacaggc     1920

ggcggaggat ctggcggagg cggatctcct gttcctccta ctggcgactc tgaggctaca     1980

cctgttccac caaccggcga cagcgaaaca gctcctgtgc caccaacagg cgattctggt     2040

gctcctccag tgcctcctac cggcgatagt ggtgctccac ctgtgcctcc aactggcgat     2100

agcggagcac ctccagttcc acctactggc gattcaggtg caccacctgt tcctccaacc     2160

ggcgattctg gcgcacctcc tgttccacca actggcgact ccggcgctcc acctgtgcca     2220

cctaccggcg actctggggc accaccagtg cctccaacag gcgacagtgg cgccccacca     2280

gtgccaccta ctggcgacgc aggacctcct cctgtgcctc caaccggcga ttcaggggct     2340

ccaccagttc caccaactgg cgatagtggg gctcctcctg ttactcctac cggggattcc     2400

gagactgccc ctgttccacc taccggcgat agcggtgccc ctccagtgcc accaaccggg     2460

gacagtgaag ctgctccagt tcctccaaca gacgattcca aagaggcc                  2508


<210>  86
<211>  3630
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ruplizumab Fab (hu5c8) HC-G4SX2-34 units

<400>  86
caggtgcagc tggtgcaatc tggcgctgag gttgtgaagc ctggcgcctc tgtgaagctg       60

tcctgtaaag cctccggcta catcttcacc agctactaca tgtactgggt caagcaggcc      120

cctggacagg gccttgagtg gatcggagag atcaaccctt ccaacggcga caccaacttc      180

aacgagaagt tcaagtccaa ggctaccctg accgtggaca agtctgcctc caccgcctac      240

atggaactgt ccagcctgag atctgaggac accgccgtgt actactgcac cagatccgac      300

ggccggaacg acatggattc ttggggacag ggcaccctgg tcaccgtgtc ctctgcttct      360

accaagggac ccagcgtgtt ccctctggct ccttccagca agtctacctc tggcggaaca      420

gctgctctgg gctgcctggt caaggactac tttcctgagc ctgtgaccgt gtcttggaac      480

tctggcgctc tgacatccgg cgtgcacacc tttccagctg tgctgcaatc ctccggcctg      540

tactctctgt cctccgtcgt gaccgtgcct tctagctctc tgggcaccca gacctacatc      600

tgcaatgtga accacaagcc ttccaacacc aaggtggaca agaaggtgga acccaagtcc      660

tgcgacaaga cccatacacc tgttcctcct actggcgact ctgaggctac acctgttcca      720

ccaaccggcg acagcgaaac agctcctgtg ccaccaacag gcgattctgg tgctcctcca      780

gtgcctccta ccggcgatag tggtgctcca cctgtgcctc caactggcga tagcggagca      840

cctccagttc cacctactgg cgattcaggt gcaccacctg ttcctccaac cggcgattct      900

ggcgcacctc ctgttccacc aactggcgac tccggcgctc cacctgtgcc acctaccggc      960

gactctgggg caccaccagt gcctccaaca ggcgacagtg gcgccccacc agtgccacca     1020

actggcgata gtggggctcc tcctgttcct cctaccggcg attcaggtgc tcctcctgtg     1080

ccaccaaccg gcgatagtgg cgcaccacca gttcctccaa ctggcgactc aggtgcccct     1140

cctgttccac ctactggcga tagcggtgct ccaccagttc caccaaccgg cgattccggt     1200

gctccaccag ttccacctac tggcgacagt ggcgcacctc ctgtgcctcc aaccggcgac     1260

agcggtgccc ctcctgttcc tccaactggc gatagtggcg ctccacctgt gccacctact     1320

ggcgattcag gcgcccctcc agtgcctcca acaggcgatt caggcgctcc accagttcct     1380

ccaaccggcg actctggggc tcctccagtt cctccaactg gcgattccgg tgcacctcca     1440

gtgccaccaa caggcgatag cggtgcacca cctgtgccac caacaggcga ctcaggtgca     1500

ccaccagttc cacctaccgg cgatagcgga gcccctcctg tgcctcctac tggcgattcc     1560

ggggctcctc ctgtgcctcc aactggcgac gctggacctc caccagtgcc accaaccggc     1620

gacagcggcg ctcctccagt gccacctact ggcgactctg gtgctcctcc tgtcacaccc     1680

actggggaca gtgaaactgc tcccgttcct cctactggcg atagtggggc ccctccagtg     1740

cctccaactg gggactctga agctgctcct gtgccaccta cagacgactc caaagaggct     1800

caggtgcagc tggtgcaatc tggcgctgag gttgtgaagc ctggcgcctc tgtgaagctg     1860

tcctgtaaag cctccggcta catcttcacc agctactaca tgtactgggt caagcaggcc     1920

cctggacagg gccttgagtg gatcggagag atcaaccctt ccaacggcga caccaacttc     1980

aacgagaagt tcaagtccaa ggctaccctg accgtggaca agtctgcctc caccgcctac     2040

atggaactgt ccagcctgag atctgaggac accgccgtgt actactgcac cagatccgac     2100

ggccggaacg acatggattc ttggggacag ggcaccctgg tcaccgtgtc ctctgcttct     2160

accaagggac ccagcgtgtt ccctctggct ccttccagca agtctacctc tggcggaaca     2220

gctgctctgg gctgcctggt caaggactac tttcctgagc ctgtgaccgt gtcttggaac     2280

tctggcgctc tgacatccgg cgtgcacacc tttccagctg tgctgcaatc ctccggcctg     2340

tactctctgt cctccgtcgt gaccgtgcct tctagctctc tgggcaccca gacctacatc     2400

tgcaatgtga accacaagcc ttccaacacc aaggtggaca agaaggtgga acccaagtcc     2460

tgcgacaaga cccatacagg cggcggagga tctggcggag gcggatctcc tgttcctcct     2520

actggcgact ctgaggctac acctgttcca ccaaccggcg acagcgaaac agctcctgtg     2580

ccaccaacag gcgattctgg tgctcctcca gtgcctccta ccggcgatag tggtgctcca     2640

cctgtgcctc caactggcga tagcggagca cctccagttc cacctactgg cgattcaggt     2700

gcaccacctg ttcctccaac cggcgattct ggcgcacctc ctgttccacc aactggcgac     2760

tccggcgctc cacctgtgcc acctaccggc gactctgggg caccaccagt gcctccaaca     2820

ggcgacagtg gcgccccacc agtgccacca actggcgata gtggggctcc tcctgttcct     2880

cctaccggcg attcaggtgc tcctcctgtg ccaccaaccg gcgatagtgg cgcaccacca     2940

gttcctccaa ctggcgactc aggtgcccct cctgttccac ctactggcga tagcggtgct     3000

ccaccagttc caccaaccgg cgattccggt gctccaccag ttccacctac tggcgacagt     3060

ggcgcacctc ctgtgcctcc aaccggcgac agcggtgccc ctcctgttcc tccaactggc     3120

gatagtggcg ctccacctgt gccacctact ggcgattcag gcgcccctcc agtgcctcca     3180

acaggcgatt caggcgctcc accagttcct ccaaccggcg actctggggc tcctccagtt     3240

cctccaactg gcgattccgg tgcacctcca gtgccaccaa caggcgatag cggtgcacca     3300

cctgtgccac caacaggcga ctcaggtgca ccaccagttc cacctaccgg cgatagcgga     3360

gcccctcctg tgcctcctac tggcgattcc ggggctcctc ctgtgcctcc aactggcgac     3420

gctggacctc caccagtgcc accaaccggc gacagcggcg ctcctccagt gccacctact     3480

ggcgactctg gtgctcctcc tgtcacaccc actggggaca gtgaaactgc tcccgttcct     3540

cctactggcg atagtggggc ccctccagtg cctccaactg gggactctga agctgctcct     3600

gtgccaccta cagacgactc caaagaggct                                      3630


<210>  87
<211>  4782
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ruplizumab Fab (hu5c8) HC-G4SX2-51 units

<400>  87
caggtgcagc tggtgcaatc tggcgctgag gttgtgaagc ctggcgcctc tgtgaagctg       60

tcctgtaaag cctccggcta catcttcacc agctactaca tgtactgggt caagcaggcc      120

cctggacagg gccttgagtg gatcggagag atcaaccctt ccaacggcga caccaacttc      180

aacgagaagt tcaagtccaa ggctaccctg accgtggaca agtctgcctc caccgcctac      240

atggaactgt ccagcctgag atctgaggac accgccgtgt actactgcac cagatccgac      300

ggccggaacg acatggattc ttggggacag ggcaccctgg tcaccgtgtc ctctgcttct      360

accaagggac ccagcgtgtt ccctctggct ccttccagca agtctacctc tggcggaaca      420

gctgctctgg gctgcctggt caaggactac tttcctgagc ctgtgaccgt gtcttggaac      480

tctggcgctc tgacatccgg cgtgcacacc tttccagctg tgctgcaatc ctccggcctg      540

tactctctgt cctccgtcgt gaccgtgcct tctagctctc tgggcaccca gacctacatc      600

tgcaatgtga accacaagcc ttccaacacc aaggtggaca agaaggtgga acccaagtcc      660

tgcgacaaga cccatacagg cggcggagga tctggcggag gcggatctcc tgttcctcct      720

actggcgact ctgaggctac acctgttcca ccaaccggcg acagcgaaac agctcctgtg      780

ccaccaacag gcgattctgg tgctcctcca gtgcctccta ccggcgatag tggtgctcca      840

cctgtgcctc caactggcga tagcggagca cctccagttc cacctactgg cgattcaggt      900

gcaccacctg ttcctccaac cggcgattct ggcgcacctc ctgttccacc aactggcgac      960

tccggcgctc cacctgtgcc acctaccggc gactctgggg caccaccagt gcctccaaca     1020

ggcgacagtg gcgccccacc agtgccacca actggcgata gtggggctcc tcctgttcct     1080

cctaccggcg attcaggtgc tcctcctgtg ccaccaaccg gcgatagtgg cgcaccacca     1140

gttcctccaa ctggcgactc aggtgcccct cctgttccac ctactggcga tagcggtgct     1200

ccaccagttc caccaaccgg cgattccggt gctccaccag ttccacctac tggcgacagt     1260

ggcgcacctc ctgtgcctcc aaccggcgac agcggtgccc ctcctgttcc tccaactggc     1320

gatagtggcg ctccacctgt gccacctact ggcgattcag gcgcccctcc agtgcctcca     1380

acaggcgatt caggcgctcc accagttcct ccaaccggcg actctggggc tcctccagtt     1440

cctccaactg gcgattccgg tgcacctcca gtgccaccaa caggcgatag cggtgcacca     1500

cctgtgccac caacaggcga ctcaggtgca ccaccagttc cacctaccgg cgatagcgga     1560

gcccctcctg tgcctcctac tggcgattcc ggggctcctc ctgtgcctcc aactggcgac     1620

tcaggggccc caccagtgcc acctactggc gactctggtg ctcctcctgt tcctcctact     1680

ggcgattctg gcgctccacc agttccacct accggcgatt ctggcgcccc acctgtgcct     1740

ccaactggcg actctggtgc tccacctgtg ccaccaacag gcgattccgg ggcacctcct     1800

gttccaccta ccggcgacag tggggctcca cctgttccac caactggcga ttctggggca     1860

ccaccagttc caccaactgg cgacagcggt gcccctccag tgccacctac cggcgattcc     1920

ggcgcacctc cagttcctcc aactggcgat agcggtgctc ctccagtgcc tccaacaggc     1980

gacagcgggg ctccaccagt gcctccaacc ggcgattcag gtgcaccacc agtgcctcca     2040

actggcgatt ccggcgcacc acctgttcca cctactggcg actcaggggc tcctccagtt     2100

cctcctaccg gcgacagcgg cgcaccacca gttccaccta ctggcgattc cggcgctcct     2160

cctgttcctc ctactggcga cgctggacct cctccagtgc cacctactgg cgactcaggc     2220

gccccacctg ttcctccaac cggcgacagt ggtgctccac cagtgacacc tacaggggac     2280

agcgaaactg cacccgttcc tccaaccggc gatagcgggg cacctcctgt gccacctact     2340

ggggatagtg aagctgctcc cgtgcctcct acagacgact ctaaagaggc tcaggtgcag     2400

ctggtgcaat ctggcgctga ggttgtgaag cctggcgcct ctgtgaagct gtcctgtaaa     2460

gcctccggct acatcttcac cagctactac atgtactggg tcaagcaggc ccctggacag     2520

ggccttgagt ggatcggaga gatcaaccct tccaacggcg acaccaactt caacgagaag     2580

ttcaagtcca aggctaccct gaccgtggac aagtctgcct ccaccgccta catggaactg     2640

tccagcctga gatctgagga caccgccgtg tactactgca ccagatccga cggccggaac     2700

gacatggatt cttggggaca gggcaccctg gtcaccgtgt cctctgcttc taccaaggga     2760

cccagcgtgt tccctctggc tccttccagc aagtctacct ctggcggaac agctgctctg     2820

ggctgcctgg tcaaggacta ctttcctgag cctgtgaccg tgtcttggaa ctctggcgct     2880

ctgacatccg gcgtgcacac ctttccagct gtgctgcaat cctccggcct gtactctctg     2940

tcctccgtcg tgaccgtgcc ttctagctct ctgggcaccc agacctacat ctgcaatgtg     3000

aaccacaagc cttccaacac caaggtggac aagaaggtgg aacccaagtc ctgcgacaag     3060

acccatacag gcggcggagg atctggcgga ggcggatctc ctgttcctcc tactggcgac     3120

tctgaggcta cacctgttcc accaaccggc gacagcgaaa cagctcctgt gccaccaaca     3180

ggcgattctg gtgctcctcc agtgcctcct accggcgata gtggtgctcc acctgtgcct     3240

ccaactggcg atagcggagc acctccagtt ccacctactg gcgattcagg tgcaccacct     3300

gttcctccaa ccggcgattc tggcgcacct cctgttccac caactggcga ctccggcgct     3360

ccacctgtgc cacctaccgg cgactctggg gcaccaccag tgcctccaac aggcgacagt     3420

ggcgccccac cagtgccacc aactggcgat agtggggctc ctcctgttcc tcctaccggc     3480

gattcaggtg ctcctcctgt gccaccaacc ggcgatagtg gcgcaccacc agttcctcca     3540

actggcgact caggtgcccc tcctgttcca cctactggcg atagcggtgc tccaccagtt     3600

ccaccaaccg gcgattccgg tgctccacca gttccaccta ctggcgacag tggcgcacct     3660

cctgtgcctc caaccggcga cagcggtgcc cctcctgttc ctccaactgg cgatagtggc     3720

gctccacctg tgccacctac tggcgattca ggcgcccctc cagtgcctcc aacaggcgat     3780

tcaggcgctc caccagttcc tccaaccggc gactctgggg ctcctccagt tcctccaact     3840

ggcgattccg gtgcacctcc agtgccacca acaggcgata gcggtgcacc acctgtgcca     3900

ccaacaggcg actcaggtgc accaccagtt ccacctaccg gcgatagcgg agcccctcct     3960

gtgcctccta ctggcgattc cggggctcct cctgtgcctc caactggcga ctcaggggcc     4020

ccaccagtgc cacctactgg cgactctggt gctcctcctg ttcctcctac tggcgattct     4080

ggcgctccac cagttccacc taccggcgat tctggcgccc cacctgtgcc tccaactggc     4140

gactctggtg ctccacctgt gccaccaaca ggcgattccg gggcacctcc tgttccacct     4200

accggcgaca gtggggctcc acctgttcca ccaactggcg attctggggc accaccagtt     4260

ccaccaactg gcgacagcgg tgcccctcca gtgccaccta ccggcgattc cggcgcacct     4320

ccagttcctc caactggcga tagcggtgct cctccagtgc ctccaacagg cgacagcggg     4380

gctccaccag tgcctccaac cggcgattca ggtgcaccac cagtgcctcc aactggcgat     4440

tccggcgcac cacctgttcc acctactggc gactcagggg ctcctccagt tcctcctacc     4500

ggcgacagcg gcgcaccacc agttccacct actggcgatt ccggcgctcc tcctgttcct     4560

cctactggcg acgctggacc tcctccagtg ccacctactg gcgactcagg cgccccacct     4620

gttcctccaa ccggcgacag tggtgctcca ccagtgacac ctacagggga cagcgaaact     4680

gcacccgttc ctccaaccgg cgatagcggg gcacctcctg tgccacctac tggggatagt     4740

gaagctgctc ccgtgcctcc tacagacgac tctaaagagg ct                        4782


<210>  88
<211>  5874
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ruplizumab Fab (hu5c8) HC-G4SX2-68 units

<400>  88
caggtgcagc tggtgcaatc tggcgctgag gttgtgaagc ctggcgcctc tgtgaagctg       60

tcctgtaaag cctccggcta catcttcacc agctactaca tgtactgggt caagcaggcc      120

cctggacagg gccttgagtg gatcggagag atcaaccctt ccaacggcga caccaacttc      180

aacgagaagt tcaagtccaa ggctaccctg accgtggaca agtctgcctc caccgcctac      240

atggaactgt ccagcctgag atctgaggac accgccgtgt actactgcac cagatccgac      300

ggccggaacg acatggattc ttggggacag ggcaccctgg tcaccgtgtc ctctgcttct      360

accaagggac ccagcgtgtt ccctctggct ccttccagca agtctacctc tggcggaaca      420

gctgctctgg gctgcctggt caaggactac tttcctgagc ctgtgaccgt gtcttggaac      480

tctggcgctc tgacatccgg cgtgcacacc tttccagctg tgctgcaatc ctccggcctg      540

tactctctgt cctccgtcgt gaccgtgcct tctagctctc tgggcaccca gacctacatc      600

tgcaatgtga accacaagcc ttccaacacc aaggtggaca agaaggtgga acccaagtcc      660

tgcgacaaga cccatacacc tgttcctcct actggcgact ctgaggctac acctgttcca      720

ccaaccggcg acagcgaaac agctcctgtg ccaccaacag gcgattctgg tgctcctcca      780

gtgcctccta ccggcgatag tggtgctcca cctgtgcctc caactggcga tagcggagca      840

cctccagttc cacctactgg cgattcaggt gcaccacctg ttcctccaac cggcgattct      900

ggcgcacctc ctgttccacc aactggcgac tccggcgctc cacctgtgcc acctaccggc      960

gactctgggg caccaccagt gcctccaaca ggcgacagtg gcgccccacc agtgccacca     1020

actggcgata gtggggctcc tcctgttcct cctaccggcg attcaggtgc tcctcctgtg     1080

ccaccaaccg gcgatagtgg cgcaccacca gttcctccaa ctggcgactc aggtgcccct     1140

cctgttccac ctactggcga tagcggtgct ccaccagttc caccaaccgg cgattccggt     1200

gctccaccag ttccacctac tggcgacagt ggcgcacctc ctgtgcctcc aaccggcgac     1260

agcggtgccc ctcctgttcc tccaactggc gatagtggcg ctccacctgt gccacctact     1320

ggcgattcag gcgcccctcc agtgcctcca acaggcgatt caggcgctcc accagttcct     1380

ccaaccggcg actctggggc tcctccagtt cctccaactg gcgattccgg tgcacctcca     1440

gtgccaccaa caggcgatag cggtgcacca cctgtgccac caacaggcga ctcaggtgca     1500

ccaccagttc cacctaccgg cgatagcgga gcccctcctg tgcctcctac tggcgattcc     1560

ggggctcctc ctgtgcctcc aactggcgac tcaggggccc caccagtgcc acctactggc     1620

gactctggtg ctcctcctgt tcctcctact ggcgattctg gcgctccacc agttccacct     1680

accggcgatt ctggcgcccc acctgtgcct ccaactggcg actctggtgc tccacctgtg     1740

ccaccaacag gcgattccgg ggcacctcct gttccaccta ccggcgacag tggggctcca     1800

cctgttccac caactggcga ttctggggca ccaccagttc caccaactgg cgacagcggt     1860

gcccctccag tgccacctac cggcgattcc ggcgcacctc cagttcctcc aactggcgat     1920

agcggtgctc ctccagtgcc tccaacaggc gacagcgggg ctccaccagt gcctccaacc     1980

ggcgattcag gtgcaccacc agtgcctcca actggcgatt ccggcgcacc acctgttcca     2040

cctactggcg actcaggggc tcctccagtt cctcctaccg gcgacagcgg cgcaccacca     2100

gttccaccta ctggcgattc cggcgctcct cctgttcctc caaccggcga tagcggggca     2160

cctcctgtgc caccaactgg cgatagcggc gctccacctg ttcctccaac tggcgacagt     2220

ggtgctcctc ctgtgccacc tactggcgac agcggggctc ctcctgtgcc accaacaggc     2280

gactctggcg cccctcctgt gccaccaacc ggcgattcag gtgcccctcc tgtgcctcct     2340

accggcgaca gtggcgctcc tccagtgcct cctactggcg actctggggc acctcctgtg     2400

ccacctactg gcgattctgg cgcaccacct gtgccaccaa ccggcgattc aggcgctcct     2460

ccagtgccac ctactggcga tagtggcgcc cctccagttc cacctactgg cgactctggc     2520

gcacctccag tgcctccaac tggcgatagt ggggcaccac ctgttccacc tactggcgat     2580

agtggggcac caccagtgcc accaaccggc gacagcggag cacctccagt gcctccaacc     2640

ggcgactccg gcgctcctcc tgttccacca actggcgaca gtggggcacc tccagttcca     2700

cctactggcg acgctggacc tccaccagtt cctccaactg gcgattcagg ggctcctcct     2760

gttccaccta ctggcgactc aggcgcacca cctgtcactc ctactgggga ttcagagaca     2820

gccccagttc ctcctactgg cgattcaggc gcacctccag ttccaccaac cggggatagt     2880

gaagctgctc ccgtgcctcc tacagatgac tccaaagagg ctcaggtgca gctggtgcaa     2940

tctggcgctg aggttgtgaa gcctggcgcc tctgtgaagc tgtcctgtaa agcctccggc     3000

tacatcttca ccagctacta catgtactgg gtcaagcagg cccctggaca gggccttgag     3060

tggatcggag agatcaaccc ttccaacggc gacaccaact tcaacgagaa gttcaagtcc     3120

aaggctaccc tgaccgtgga caagtctgcc tccaccgcct acatggaact gtccagcctg     3180

agatctgagg acaccgccgt gtactactgc accagatccg acggccggaa cgacatggat     3240

tcttggggac agggcaccct ggtcaccgtg tcctctgctt ctaccaaggg acccagcgtg     3300

ttccctctgg ctccttccag caagtctacc tctggcggaa cagctgctct gggctgcctg     3360

gtcaaggact actttcctga gcctgtgacc gtgtcttgga actctggcgc tctgacatcc     3420

ggcgtgcaca cctttccagc tgtgctgcaa tcctccggcc tgtactctct gtcctccgtc     3480

gtgaccgtgc cttctagctc tctgggcacc cagacctaca tctgcaatgt gaaccacaag     3540

ccttccaaca ccaaggtgga caagaaggtg gaacccaagt cctgcgacaa gacccataca     3600

ggcggcggag gatctggcgg aggcggatct cctgttcctc ctactggcga ctctgaggct     3660

acacctgttc caccaaccgg cgacagcgaa acagctcctg tgccaccaac aggcgattct     3720

ggtgctcctc cagtgcctcc taccggcgat agtggtgctc cacctgtgcc tccaactggc     3780

gatagcggag cacctccagt tccacctact ggcgattcag gtgcaccacc tgttcctcca     3840

accggcgatt ctggcgcacc tcctgttcca ccaactggcg actccggcgc tccacctgtg     3900

ccacctaccg gcgactctgg ggcaccacca gtgcctccaa caggcgacag tggcgcccca     3960

ccagtgccac caactggcga tagtggggct cctcctgttc ctcctaccgg cgattcaggt     4020

gctcctcctg tgccaccaac cggcgatagt ggcgcaccac cagttcctcc aactggcgac     4080

tcaggtgccc ctcctgttcc acctactggc gatagcggtg ctccaccagt tccaccaacc     4140

ggcgattccg gtgctccacc agttccacct actggcgaca gtggcgcacc tcctgtgcct     4200

ccaaccggcg acagcggtgc ccctcctgtt cctccaactg gcgatagtgg cgctccacct     4260

gtgccaccta ctggcgattc aggcgcccct ccagtgcctc caacaggcga ttcaggcgct     4320

ccaccagttc ctccaaccgg cgactctggg gctcctccag ttcctccaac tggcgattcc     4380

ggtgcacctc cagtgccacc aacaggcgat agcggtgcac cacctgtgcc accaacaggc     4440

gactcaggtg caccaccagt tccacctacc ggcgatagcg gagcccctcc tgtgcctcct     4500

actggcgatt ccggggctcc tcctgtgcct ccaactggcg actcaggggc cccaccagtg     4560

ccacctactg gcgactctgg tgctcctcct gttcctccta ctggcgattc tggcgctcca     4620

ccagttccac ctaccggcga ttctggcgcc ccacctgtgc ctccaactgg cgactctggt     4680

gctccacctg tgccaccaac aggcgattcc ggggcacctc ctgttccacc taccggcgac     4740

agtggggctc cacctgttcc accaactggc gattctgggg caccaccagt tccaccaact     4800

ggcgacagcg gtgcccctcc agtgccacct accggcgatt ccggcgcacc tccagttcct     4860

ccaactggcg atagcggtgc tcctccagtg cctccaacag gcgacagcgg ggctccacca     4920

gtgcctccaa ccggcgattc aggtgcacca ccagtgcctc caactggcga ttccggcgca     4980

ccacctgttc cacctactgg cgactcaggg gctcctccag ttcctcctac cggcgacagc     5040

ggcgcaccac cagttccacc tactggcgat tccggcgctc ctcctgttcc tccaaccggc     5100

gatagcgggg cacctcctgt gccaccaact ggcgatagcg gcgctccacc tgttcctcca     5160

actggcgaca gtggtgctcc tcctgtgcca cctactggcg acagcggggc tcctcctgtg     5220

ccaccaacag gcgactctgg cgcccctcct gtgccaccaa ccggcgattc aggtgcccct     5280

cctgtgcctc ctaccggcga cagtggcgct cctccagtgc ctcctactgg cgactctggg     5340

gcacctcctg tgccacctac tggcgattct ggcgcaccac ctgtgccacc aaccggcgat     5400

tcaggcgctc ctccagtgcc acctactggc gatagtggcg cccctccagt tccacctact     5460

ggcgactctg gcgcacctcc agtgcctcca actggcgata gtggggcacc acctgttcca     5520

cctactggcg atagtggggc accaccagtg ccaccaaccg gcgacagcgg agcacctcca     5580

gtgcctccaa ccggcgactc cggcgctcct cctgttccac caactggcga cagtggggca     5640

cctccagttc cacctactgg cgacgctgga cctccaccag ttcctccaac tggcgattca     5700

ggggctcctc ctgttccacc tactggcgac tcaggcgcac cacctgtcac tcctactggg     5760

gattcagaga cagccccagt tcctcctact ggcgattcag gcgcacctcc agttccacca     5820

accggggata gtgaagctgc tcccgtgcct cctacagatg actccaaaga ggct           5874


<210>  89
<211>  654
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ruplizumab (hu5c8) LC

<400>  89
gacatcgtgc tgacccagtc tccagccaca ctgagtgtgt ctccaggcga gagagccacc       60

atcagctgta gagcctctca gcgggtgtcc tcctccacct actcttacat gcactggtat      120

cagcagaagc ccggccagcc tcctaagctg ctgattaagt acgcctccaa cctggaatcc      180

ggcgtgcccg ctagattttc cggctctggc tctggcaccg actttaccct gaccatctcc      240

tccgtggaac ccgaggattt cgccacctac tactgccagc actcctggga gatcccacct      300

acatttggcg gaggcaccaa gctggaaatc aagcggacag tggccgctcc ttccgtgttc      360

atcttcccac cttccgacga gcagctgaag tccggcacag cttctgtcgt gtgcctgctg      420

aacaacttct accctcggga agccaaggtg cagtggaagg tggacaatgc cctgcagtcc      480

ggcaactccc aagagtctgt gaccgagcag gactccaagg acagcaccta cagcctgtcc      540

tccacactga ccctgtccaa ggccgactac gagaagcaca aggtgtacgc ctgcgaagtg      600

acccatcagg gcctgtctag ccctgtgacc aagtctttca accggggcga gtgt            654


<210>  90
<211>  2460
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ruplizumab (hu5c8) LC-G4SX2-17 units

<400>  90
gacatcgtgc tgacccagtc tccagccaca ctgagtgtgt ctccaggcga gagagccacc       60

atcagctgta gagcctctca gcgggtgtcc tcctccacct actcttacat gcactggtat      120

cagcagaagc ccggccagcc tcctaagctg ctgattaagt acgcctccaa cctggaatcc      180

ggcgtgcccg ctagattttc cggctctggc tctggcaccg actttaccct gaccatctcc      240

tccgtggaac ccgaggattt cgccacctac tactgccagc actcctggga gatcccacct      300

acatttggcg gaggcaccaa gctggaaatc aagcggacag tggccgctcc ttccgtgttc      360

atcttcccac cttccgacga gcagctgaag tccggcacag cttctgtcgt gtgcctgctg      420

aacaacttct accctcggga agccaaggtg cagtggaagg tggacaatgc cctgcagtcc      480

ggcaactccc aagagtctgt gaccgagcag gactccaagg acagcaccta cagcctgtcc      540

tccacactga ccctgtccaa ggccgactac gagaagcaca aggtgtacgc ctgcgaagtg      600

acccatcagg gcctgtctag ccctgtgacc aagtctttca acagaggcga gtgtcctgtt      660

cctcctactg gcgactctga ggctacacct gttccaccaa ccggcgacag cgaaacagct      720

cctgtgccac caacaggcga ttctggtgct cctccagtgc ctcctaccgg cgatagtggt      780

gctccacctg tgcctccaac tggcgatagc ggagcacctc cagttccacc aactggcgat      840

tcaggcgcac cacctgtgcc acctaccggc gactctggcg cacctcctgt tcctccaacc      900

ggcgatagtg gcgcccctcc tgttccacct actggcgata gtggtgcacc tcctgtgcca      960

ccaaccggcg atagcggtgc cccaccagtg ccacctactg gcgacgcagg acctcctcct     1020

gtgcctccta ctggcgattc aggtgctcct cctgttccac caactggcga ctctggggct     1080

cctcctgtga caccaactgg ggattctgag acagccccag tgcctccaac aggcgactcc     1140

ggggcaccac cagtgccacc aacaggggac agtgaagctg ctcccgtgcc tccaaccgac     1200

gattctaaag aggctgacat cgtgctgacc cagtctccag ccacactgag tgtgtctcca     1260

ggcgagagag ccaccatcag ctgtagagcc tctcagcggg tgtcctcctc cacctactct     1320

tacatgcact ggtatcagca gaagcccggc cagcctccta agctgctgat taagtacgcc     1380

tccaacctgg aatccggcgt gcccgctaga ttttccggct ctggctctgg caccgacttt     1440

accctgacca tctcctccgt ggaacccgag gatttcgcca cctactactg ccagcactcc     1500

tgggagatcc cacctacatt tggcggaggc accaagctgg aaatcaagcg gacagtggcc     1560

gctccttccg tgttcatctt cccaccttcc gacgagcagc tgaagtccgg cacagcttct     1620

gtcgtgtgcc tgctgaacaa cttctaccct cgggaagcca aggtgcagtg gaaggtggac     1680

aatgccctgc agtccggcaa ctcccaagag tctgtgaccg agcaggactc caaggacagc     1740

acctacagcc tgtcctccac actgaccctg tccaaggccg actacgagaa gcacaaggtg     1800

tacgcctgcg aagtgaccca tcagggcctg tctagccctg tgaccaagtc tttcaacaga     1860

ggcgagtgtg gcggcggagg aagcggaggc ggaggatctc ctgttcctcc tactggcgac     1920

tctgaggcta cacctgttcc accaaccggc gacagcgaaa cagctcctgt gccaccaaca     1980

ggcgattctg gtgctcctcc agtgcctcct accggcgata gtggtgctcc acctgtgcct     2040

ccaactggcg atagcggagc acctccagtt ccaccaactg gcgattcagg cgcaccacct     2100

gtgccaccta ccggcgactc tggcgcacct cctgttcctc caaccggcga tagtggcgcc     2160

cctcctgttc cacctactgg cgatagtggt gcacctcctg tgccaccaac cggcgatagc     2220

ggtgccccac cagtgccacc tactggcgac gcaggacctc ctcctgtgcc tcctactggc     2280

gattcaggtg ctcctcctgt tccaccaact ggcgactctg gggctcctcc tgtgacacca     2340

actggggatt ctgagacagc cccagtgcct ccaacaggcg actccggggc accaccagtg     2400

ccaccaacag gggacagtga agctgctccc gtgcctccaa ccgacgattc taaagaggct     2460


<210>  91
<211>  3582
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ruplizumab (hu5c8) LC-G4SX2-34 units

<400>  91
gacatcgtgc tgacccagtc tccagccaca ctgagtgtgt ctccaggcga gagagccacc       60

atcagctgta gagcctctca gcgggtgtcc tcctccacct actcttacat gcactggtat      120

cagcagaagc ccggccagcc tcctaagctg ctgattaagt acgcctccaa cctggaatcc      180

ggcgtgcccg ctagattttc cggctctggc tctggcaccg actttaccct gaccatctcc      240

tccgtggaac ccgaggattt cgccacctac tactgccagc actcctggga gatcccacct      300

acatttggcg gaggcaccaa gctggaaatc aagcggacag tggccgctcc ttccgtgttc      360

atcttcccac cttccgacga gcagctgaag tccggcacag cttctgtcgt gtgcctgctg      420

aacaacttct accctcggga agccaaggtg cagtggaagg tggacaatgc cctgcagtcc      480

ggcaactccc aagagtctgt gaccgagcag gactccaagg acagcaccta cagcctgtcc      540

tccacactga ccctgtccaa ggccgactac gagaagcaca aggtgtacgc ctgcgaagtg      600

acccatcagg gcctgtctag ccctgtgacc aagtctttca acagaggcga gtgtcctgtt      660

cctcctactg gcgactctga ggctacacct gttccaccaa ccggcgacag cgaaacagct      720

cctgtgccac caacaggcga ttctggtgct cctccagtgc ctcctaccgg cgatagtggt      780

gctccacctg tgcctccaac tggcgatagc ggagcacctc cagttccacc aactggcgat      840

tcaggcgcac cacctgtgcc acctaccggc gactctggcg cacctcctgt tcctccaacc      900

ggcgatagtg gcgcccctcc tgttccacct actggcgata gtggtgcacc tcctgtgcca      960

ccaaccggcg atagcggtgc cccaccagtg ccaccaacag gcgacagtgg cgctccacca     1020

gttccaccaa ccggcgattc tggggctcca cctgtgccac ctactggcga ttcaggtgct     1080

ccaccagttc ctccaactgg cgactccggt gctcctcctg ttccacctac cggcgactca     1140

ggtgcccctc cagtgccacc tactggcgac agcggagccc cacctgttcc tccaactggc     1200

gattctggcg ctccaccagt gccaccaaca ggcgattccg gcgctccacc tgttccacca     1260

actggcgaca gtggtgctcc tccagttcct cctactggcg attctggggc acctccagtt     1320

ccacctaccg gcgatagcgg cgctcctcca gttcctccta ccggcgacag cggggcacca     1380

ccagtgcctc caaccggcga ctcaggcgcc ccacctgtgc caccaacagg cgatagcggg     1440

gctcctcctg tgccaccaac tggcgactcc ggggcacctc cagtgccacc aacaggcgac     1500

tcaggtgccc ctcctgttcc tcctaccggc gattcaggcg ctcctcctgt gcctcctact     1560

ggcgacgctg gacctcctcc agtgcctcca acaggcgata gcggcgcacc acctgttcca     1620

cctactggcg attccggggc tcctcctgtc actccaacag gggattcaga gacagctccc     1680

gtgcctccaa ctggcgacag tggcgcacct ccagtgcctc caactgggga ttctgaagct     1740

gctcctgtgc ctccaaccga cgacagcaaa gaggctgaca tcgtgctgac ccagtctcca     1800

gccacactga gtgtgtctcc aggcgagaga gccaccatca gctgtagagc ctctcagcgg     1860

gtgtcctcct ccacctactc ttacatgcac tggtatcagc agaagcccgg ccagcctcct     1920

aagctgctga ttaagtacgc ctccaacctg gaatccggcg tgcccgctag attttccggc     1980

tctggctctg gcaccgactt taccctgacc atctcctccg tggaacccga ggatttcgcc     2040

acctactact gccagcactc ctgggagatc ccacctacat ttggcggagg caccaagctg     2100

gaaatcaagc ggacagtggc cgctccttcc gtgttcatct tcccaccttc cgacgagcag     2160

ctgaagtccg gcacagcttc tgtcgtgtgc ctgctgaaca acttctaccc tcgggaagcc     2220

aaggtgcagt ggaaggtgga caatgccctg cagtccggca actcccaaga gtctgtgacc     2280

gagcaggact ccaaggacag cacctacagc ctgtcctcca cactgaccct gtccaaggcc     2340

gactacgaga agcacaaggt gtacgcctgc gaagtgaccc atcagggcct gtctagccct     2400

gtgaccaagt ctttcaacag aggcgagtgt ggcggcggag gaagcggagg cggaggatct     2460

cctgttcctc ctactggcga ctctgaggct acacctgttc caccaaccgg cgacagcgaa     2520

acagctcctg tgccaccaac aggcgattct ggtgctcctc cagtgcctcc taccggcgat     2580

agtggtgctc cacctgtgcc tccaactggc gatagcggag cacctccagt tccaccaact     2640

ggcgattcag gcgcaccacc tgtgccacct accggcgact ctggcgcacc tcctgttcct     2700

ccaaccggcg atagtggcgc ccctcctgtt ccacctactg gcgatagtgg tgcacctcct     2760

gtgccaccaa ccggcgatag cggtgcccca ccagtgccac caacaggcga cagtggcgct     2820

ccaccagttc caccaaccgg cgattctggg gctccacctg tgccacctac tggcgattca     2880

ggtgctccac cagttcctcc aactggcgac tccggtgctc ctcctgttcc acctaccggc     2940

gactcaggtg cccctccagt gccacctact ggcgacagcg gagccccacc tgttcctcca     3000

actggcgatt ctggcgctcc accagtgcca ccaacaggcg attccggcgc tccacctgtt     3060

ccaccaactg gcgacagtgg tgctcctcca gttcctccta ctggcgattc tggggcacct     3120

ccagttccac ctaccggcga tagcggcgct cctccagttc ctcctaccgg cgacagcggg     3180

gcaccaccag tgcctccaac cggcgactca ggcgccccac ctgtgccacc aacaggcgat     3240

agcggggctc ctcctgtgcc accaactggc gactccgggg cacctccagt gccaccaaca     3300

ggcgactcag gtgcccctcc tgttcctcct accggcgatt caggcgctcc tcctgtgcct     3360

cctactggcg acgctggacc tcctccagtg cctccaacag gcgatagcgg cgcaccacct     3420

gttccaccta ctggcgattc cggggctcct cctgtcactc caacagggga ttcagagaca     3480

gctcccgtgc ctccaactgg cgacagtggc gcacctccag tgcctccaac tggggattct     3540

gaagctgctc ctgtgcctcc aaccgacgac agcaaagagg ct                        3582


<210>  92
<211>  759
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ruplizumab  (hu5c8) scFv (VH-VL) - C-tag

<400>  92
caggtgcagc tggtgcaatc tggcgctgag gttgtgaagc ctggcgcctc tgtgaagctg       60

tcctgtaaag cctccggcta catcttcacc agctactaca tgtactgggt caagcaggcc      120

cctggacagg gccttgagtg gatcggagag atcaaccctt ccaacggcga caccaacttc      180

aacgagaagt tcaagtccaa ggctaccctg accgtggaca agtctgcctc caccgcctac      240

atggaactgt ccagcctgag atctgaggac accgccgtgt actactgcac cagatccgac      300

ggccggaacg acatggattc ttggggacag ggcaccctgg tcaccgtgtc atctgcatct      360

ggtggcggag gatctggcgg aggtggaagt ggcggatctg acatcgtgct gacccagtct      420

ccagccacac tgagtgtgtc tccaggcgag agagccacca tcagctgtag agcctctcag      480

cgggtgtcct cctccaccta ctcttacatg cactggtatc agcagaagcc cggccagcct      540

cctaagctgc tgattaagta cgcctccaac ctggaatccg gcgtgcccgc tagattttcc      600

ggctctggct ctggcaccga ctttaccctg acaatctcct ccgtggaacc cgaggacttc      660

gccacctact actgccagca ctcctgggag atcccaccta catttggcgg aggcaccaag      720

ctggaaatca aaggcggcgg aggctctgag cctgaggct                             759


<210>  93
<211>  771
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ruplizumab  (hu5c8) scFv (VL-VH) - C-tag

<400>  93
gacatcgtgc tgacccagtc tccagccaca ctgagtgtgt ctccaggcga gagagccacc       60

atcagctgta gagcctctca gcgggtgtcc tcctccacct actcttacat gcactggtat      120

cagcagaagc ccggccagcc tcctaagctg ctgattaagt acgcctccaa cctggaatcc      180

ggcgtgcccg ctagattttc cggctctggc tctggcaccg actttaccct gaccatctcc      240

tccgtggaac ccgaggattt cgccacctac tactgccagc actcctggga gatcccacct      300

acatttggcg gaggcaccaa gctggaaatc aagggcgctt ctggtggcgg aggaagcgga      360

ggcggaggat ctggtggatc ttctcaggtg cagctggtgc agtctggcgc cgaagttgtg      420

aaacctggcg cctccgtgaa gctgtcctgt aaagcctccg gctacatctt caccagctac      480

tacatgtact gggtcaagca ggcccctgga cagggccttg agtggatcgg agagatcaac      540

ccttccaacg gcgacaccaa cttcaacgag aagttcaagt ccaaggccac tctgaccgtg      600

gacaagtctg cctccaccgc ctacatggaa ctgtccagcc tgagatctga ggacaccgcc      660

gtgtactact gtaccagatc tgacggccgg aacgacatgg actcttgggg acagggaacc      720

ctggtcaccg tgtcatctgc aagtggcggt ggcggatctg aacctgaggc t               771


<210>  94
<211>  678
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ruplizumab Fab (hu5c8) HC secreted

<400>  94
caggttcagc tggttcagag cggtgccgaa gttgttaaac cgggtgcaag cgttaaactg       60

agctgtaaag caagcggtta tatcttcacc agctattata tgtactgggt gaaacaggca      120

cctggtcaag gtctggaatg gattggtgaa attaatccga gcaatggcga taccaacttc      180

aacgaaaaat tcaaaagcaa agcaaccctg accgttgata aaagcgcaag caccgcatat      240

atggaactga gtagcctgcg tagcgaagat accgcagtgt attattgtac ccgtagtgat      300

ggtcgtaatg atatggatag ctggggtcag ggcaccctgg ttaccgttag cagcgcaagt      360

accaaaggtc cgagcgtgtt tccgctggca ccgagcagca aaagcaccag cggtggcacc      420

gcagcactgg gttgtctggt taaagattat tttccggaac cggttaccgt gagctggaat      480

agtggtgcac tgaccagtgg tgttcatacc tttccggcag ttctgcagag cagcggtctg      540

tatagcctga gcagtgttgt taccgttccg agcagtagcc tgggcaccca gacctatatt      600

tgtaatgtta atcataagcc gagcaacacc aaagtggaca aaaaagttga accgaaaagc      660

tgcgataaaa cccatacc                                                    678


<210>  95
<211>  1362
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ruplizumab Fab (hu5c8) HC cytoplasmic

<400>  95
atgcaggttc agctggttca gagcggtgcc gaagttgtta aaccgggtgc aagcgttaaa       60

ctgagctgta aagcaagcgg ttatatcttc accagctatt atatgtactg ggtgaaacag      120

gcacctggtc aaggtctgga atggattggt gaaattaatc cgagcaatgg cgataccaac      180

ttcaacgaaa aattcaaaag caaagcaacc ctgaccgttg ataaaagcgc aagcaccgca      240

tatatggaac tgagtagcct gcgtagcgaa gataccgcag tgtattattg tacccgtagt      300

gatggtcgta atgatatgga tagctggggt cagggcaccc tggttaccgt tagcagcgca      360

agtaccaaag gtccgagcgt gtttccgctg gcaccgagca gcaaaagcac cagcggtggc      420

accgcagcac tgggttgtct ggttaaagat tattttccgg aaccggttac cgtgagctgg      480

aatagtggtg cactgaccag tggtgttcat acctttccgg cagttctgca gagcagcggt      540

ctgtatagcc tgagcagtgt tgttaccgtt ccgagcagta gcctgggcac ccagacctat      600

atttgtaatg ttaatcataa gccgagcaac accaaagtgg acaaaaaagt tgaaccgaaa      660

agctgcgata aaacccatac catgcaggtt cagctggttc agagcggtgc cgaagttgtt      720

aaaccgggtg caagcgttaa actgagctgt aaagcaagcg gttatatctt caccagctat      780

tatatgtact gggtgaaaca ggcacctggt caaggtctgg aatggattgg tgaaattaat      840

ccgagcaatg gcgataccaa cttcaacgaa aaattcaaaa gcaaagcaac cctgaccgtt      900

gataaaagcg caagcaccgc atatatggaa ctgagtagcc tgcgtagcga agataccgca      960

gtgtattatt gtacccgtag tgatggtcgt aatgatatgg atagctgggg tcagggcacc     1020

ctggttaccg ttagcagcgc aagtaccaaa ggtccgagcg tgtttccgct ggcaccgagc     1080

agcaaaagca ccagcggtgg caccgcagca ctgggttgtc tggttaaaga ttattttccg     1140

gaaccggtta ccgtgagctg gaatagtggt gcactgacca gtggtgttca tacctttccg     1200

gcagttctgc agagcagcgg tctgtatagc ctgagcagtg ttgttaccgt tccgagcagt     1260

agcctgggca cccagaccta tatttgtaat gttaatcata agccgagcaa caccaaagtg     1320

gacaaaaaag ttgaaccgaa aagctgcgat aaaacccata cc                        1362


<210>  96
<211>  3612
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ruplizumab Fab (hu5c8) HC 34 units

<400>  96
atgcaggttc agctggttca gagcggtgcc gaagttgtta aaccgggtgc aagcgttaaa       60

ctgagctgta aagcaagcgg ttatatcttc accagctatt atatgtactg ggtgaaacag      120

gcacctggtc aaggtctgga atggattggt gaaattaatc cgagcaatgg cgataccaac      180

ttcaacgaaa aattcaaaag caaagcaacc ctgaccgttg ataaaagcgc aagcaccgca      240

tatatggaac tgagtagcct gcgtagcgaa gataccgcag tgtattattg tacccgtagt      300

gatggtcgta atgatatgga tagctggggt cagggcaccc tggttaccgt tagcagcgca      360

agtaccaaag gtccgagcgt gtttccgctg gcaccgagca gcaaaagcac cagcggtggc      420

accgcagcac tgggttgtct ggttaaagat tattttccgg aaccggttac cgtgagctgg      480

aatagtggtg cactgaccag tggtgttcat acctttccgg cagttctgca gagcagcggt      540

ctgtatagcc tgagcagtgt tgttaccgtt ccgagcagta gcctgggcac ccagacctat      600

atttgtaatg ttaatcataa gccgagcaac accaaagtgg acaaaaaagt tgaaccgaaa      660

agctgcgata aaacccatac cccggttccg cctaccggtg atagcgaagc aacaccggtg      720

cctccgaccg gtgattcaga aaccgcaccg gttccaccga caggcgatag cggtgcacct      780

cctgttcctc caacaggtga ttctggtgcc cctccggtgc caccaactgg cgattcaggt      840

gctccgccag ttccgccaac gggtgacagt ggtgccccac cagtaccgcc tacaggggat      900

agtggcgcac cgccagtgcc acctacaggt gactcaggcg caccacctgt accaccgact      960

ggggactcgg gtgcgcctcc agtacctccg actggtgaca gcggagcgcc acctgtccca     1020

cctacgggtg attccggtgc tccaccggtc ccaccgactg gtgattctgg cgcaccgcct     1080

gtccctccga caggcgacag tggcgcacca ccggttccac caaccggtga ctcaggtgcg     1140

cctccggttc ctcctacagg cgattcaggg gcacctccag tcccaccaac aggggatagc     1200

ggagccccac cagttcctcc gactggggat tcaggtgccc cacctgttcc accgaccggt     1260

gatagtggtg ctccacctgt gcctccgact ggcgatagcg gagcccctcc ggttccacct     1320

acaggtgaca gtggtgcccc tccggttcct ccgacgggtg actccggtgc acctccagtt     1380

ccacctactg gcgatagtgg cgcacctcct gtaccgccta ctggcgacag cggtgctccg     1440

cctgtaccac ctaccggtga ctctggtgcc ccaccagtcc ctccaacggg tgatagcggt     1500

gctcctccag tccctcctac cggtgattcg ggtgcacctc ctgtgccacc tacgggtgac     1560

agcggtgcac cacctgtgcc accaactggt gatgccggtc cgccacctgt accgccaacc     1620

ggtgatagcg gagcgcctcc tgtaccgcca acaggggatt caggcgctcc tcctgtgacg     1680

ccgacaggtg attccgagac agcccctgtt ccgccaacag gcgactcggg tgcaccaccg     1740

gttccgccta cgggtgattc agaagcagct ccggttccgc caactgatga tagtaaagaa     1800

gcaatgcagg ttcagctggt tcagagcggt gccgaagttg ttaaaccggg tgcaagcgtt     1860

aaactgagct gtaaagcaag cggttatatc ttcaccagct attatatgta ctgggtgaaa     1920

caggcacctg gtcaaggtct ggaatggatt ggtgaaatta atccgagcaa tggcgatacc     1980

aacttcaacg aaaaattcaa aagcaaagca accctgaccg ttgataaaag cgcaagcacc     2040

gcatatatgg aactgagtag cctgcgtagc gaagataccg cagtgtatta ttgtacccgt     2100

agtgatggtc gtaatgatat ggatagctgg ggtcagggca ccctggttac cgttagcagc     2160

gcaagtacca aaggtccgag cgtgtttccg ctggcaccga gcagcaaaag caccagcggt     2220

ggcaccgcag cactgggttg tctggttaaa gattattttc cggaaccggt taccgtgagc     2280

tggaatagtg gtgcactgac cagtggtgtt catacctttc cggcagttct gcagagcagc     2340

ggtctgtata gcctgagcag tgttgttacc gttccgagca gtagcctggg cacccagacc     2400

tatatttgta atgttaatca taagccgagc aacaccaaag tggacaaaaa agttgaaccg     2460

aaaagctgcg ataaaaccca taccggatct ccggttccgc ctaccggtga tagcgaagca     2520

acaccggtgc ctccgaccgg tgattcagaa accgcaccgg ttccaccgac aggcgatagc     2580

ggtgcacctc ctgttcctcc aacaggtgat tctggtgccc ctccggtgcc accaactggc     2640

gattcaggtg ctccgccagt tccgccaacg ggtgacagtg gtgccccacc agtaccgcct     2700

acaggggata gtggcgcacc gccagtgcca cctacaggtg actcaggcgc accacctgta     2760

ccaccgactg gggactcggg tgcgcctcca gtacctccga ctggtgacag cggagcgcca     2820

cctgtcccac ctacgggtga ttccggtgct ccaccggtcc caccgactgg tgattctggc     2880

gcaccgcctg tccctccgac aggcgacagt ggcgcaccac cggttccacc aaccggtgac     2940

tcaggtgcgc ctccggttcc tcctacaggc gattcagggg cacctccagt cccaccaaca     3000

ggggatagcg gagccccacc agttcctccg actggggatt caggtgcccc acctgttcca     3060

ccgaccggtg atagtggtgc tccacctgtg cctccgactg gcgatagcgg agcccctccg     3120

gttccaccta caggtgacag tggtgcccct ccggttcctc cgacgggtga ctccggtgca     3180

cctccagttc cacctactgg cgatagtggc gcacctcctg taccgcctac tggcgacagc     3240

ggtgctccgc ctgtaccacc taccggtgac tctggtgccc caccagtccc tccaacgggt     3300

gatagcggtg ctcctccagt ccctcctacc ggtgattcgg gtgcacctcc tgtgccacct     3360

acgggtgaca gcggtgcacc acctgtgcca ccaactggtg atgccggtcc gccacctgta     3420

ccgccaaccg gtgatagcgg agcgcctcct gtaccgccaa caggggattc aggcgctcct     3480

cctgtgacgc cgacaggtga ttccgagaca gcccctgttc cgccaacagg cgactcgggt     3540

gcaccaccgg ttccgcctac gggtgattca gaagcagctc cggttccgcc aactgatgat     3600

agtaaagaag ca                                                         3612


<210>  97
<211>  654
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ruplizumab Fab (hu5c8) LC secreted

<400>  97
gatattgttc tgacccagag tccggcaaca ctgagcgtta gtccgggtga acgtgcaacc       60

attagctgtc gtgcaagcca gcgtgttagc agcagcacct atagttatat gcattggtat      120

cagcagaaac cgggtcagcc tccgaaactg ctgatcaaat atgcaagcaa tctggaaagc      180

ggtgttccgg cacgttttag cggtagcggt agtggcaccg attttaccct gaccattagc      240

agcgttgaac cggaagattt tgcaacctat tattgtcagc atagctggga aattccgcct      300

acctttggtg gtggcaccaa actggaaatt aaacgtaccg ttgcagcacc gagcgttttt      360

atctttccgc ctagtgatga acagctgaaa agcggcaccg caagcgttgt ttgtctgctg      420

aataactttt atccgcgtga agcaaaagtt cagtggaaag ttgataatgc actgcagagc      480

ggtaatagcc aagaaagcgt taccgaacag gatagcaaag atagcaccta ttcactgagc      540

agcaccctga cactgagcaa agcagattat gaaaaacaca aagtgtatgc ctgcgaagtt      600

acccatcagg gtctgagcag tccggttacc aaaagtttta atcgtggtga atgc            654


<210>  98
<211>  657
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ruplizumab Fab (hu5c8) LC cytoplasmic

<400>  98
atggatattg ttctgaccca gagtccggca acactgagcg ttagtccggg tgaacgtgca       60

accattagct gtcgtgcaag ccagcgtgtt agcagcagca cctatagtta tatgcattgg      120

tatcagcaga aaccgggtca gcctccgaaa ctgctgatca aatatgcaag caatctggaa      180

agcggtgttc cggcacgttt tagcggtagc ggtagtggca ccgattttac cctgaccatt      240

agcagcgttg aaccggaaga ttttgcaacc tattattgtc agcatagctg ggaaattccg      300

cctacctttg gtggtggcac caaactggaa attaaacgta ccgttgcagc accgagcgtt      360

tttatctttc cgcctagtga tgaacagctg aaaagcggca ccgcaagcgt tgtttgtctg      420

ctgaataact tttatccgcg tgaagcaaaa gttcagtgga aagttgataa tgcactgcag      480

agcggtaata gccaagaaag cgttaccgaa caggatagca aagatagcac ctattcactg      540

agcagcaccc tgacactgag caaagcagat tatgaaaaac acaaagtgta tgcctgcgaa      600

gttacccatc agggtctgag cagtccggtt accaaaagtt ttaatcgtgg tgaatgc         657


<210>  99
<211>  3624
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ruplizumab Fab (hu5c8) HC 34 units

<400>  99
caggttcagc tggttcagag cggtgccgaa gttgttaaac cgggtgcaag cgttaaactg       60

agctgtaaag caagcggtta tatcttcacc agctattata tgtactgggt gaaacaggca      120

cctggtcaag gtctggaatg gattggtgaa attaatccga gcaatggcga taccaacttc      180

aacgaaaaat tcaaaagcaa agcaaccctg accgttgata aaagcgcaag caccgcatat      240

atggaactga gtagcctgcg tagcgaagat accgcagtgt attattgtac ccgtagtgat      300

ggtcgtaatg atatggatag ctggggtcag ggcaccctgg ttaccgttag cagcgcaagt      360

accaaaggtc cgagcgtgtt tccgctggca ccgagcagca aaagcaccag cggtggcacc      420

gcagcactgg gttgtctggt taaagattat tttccggaac cggttaccgt gagctggaat      480

agtggtgcac tgaccagtgg tgttcatacc tttccggcag ttctgcagag cagcggtctg      540

tatagcctga gcagtgttgt taccgttccg agcagtagcc tgggcaccca gacctatatt      600

tgtaatgtta atcataagcc gagcaacacc aaagtggaca aaaaagttga accgaaaagc      660

tgcgataaaa cccataccgg atctccggtt ccgcctaccg gtgatagcga agcaacaccg      720

gtgcctccga ccggtgattc agaaaccgca ccggttccac cgacaggcga tagcggtgca      780

cctcctgttc ctccaacagg tgattctggt gcccctccgg tgccaccaac tggcgattca      840

ggtgctccgc cagttccgcc aacgggtgac agtggtgccc caccagtacc gcctacaggg      900

gatagtggcg caccgccagt gccacctaca ggtgactcag gcgcaccacc tgtaccaccg      960

actggggact cgggtgcgcc tccagtacct ccgactggtg acagcggagc gccacctgtc     1020

ccacctacgg gtgattccgg tgctccaccg gtcccaccga ctggtgattc tggcgcaccg     1080

cctgtccctc cgacaggcga cagtggcgca ccaccggttc caccaaccgg tgactcaggt     1140

gcgcctccgg ttcctcctac aggcgattca ggggcacctc cagtcccacc aacaggggat     1200

agcggagccc caccagttcc tccgactggg gattcaggtg ccccacctgt tccaccgacc     1260

ggtgatagtg gtgctccacc tgtgcctccg actggcgata gcggagcccc tccggttcca     1320

cctacaggtg acagtggtgc ccctccggtt cctccgacgg gtgactccgg tgcacctcca     1380

gttccaccta ctggcgatag tggcgcacct cctgtaccgc ctactggcga cagcggtgct     1440

ccgcctgtac cacctaccgg tgactctggt gccccaccag tccctccaac gggtgatagc     1500

ggtgctcctc cagtccctcc taccggtgat tcgggtgcac ctcctgtgcc acctacgggt     1560

gacagcggtg caccacctgt gccaccaact ggtgatgccg gtccgccacc tgtaccgcca     1620

accggtgata gcggagcgcc tcctgtaccg ccaacagggg attcaggcgc tcctcctgtg     1680

acgccgacag gtgattccga gacagcccct gttccgccaa caggcgactc gggtgcacca     1740

ccggttccgc ctacgggtga ttcagaagca gctccggttc cgccaactga tgatagtaaa     1800

gaagcaggat cccaggttca gctggttcag agcggtgccg aagttgttaa accgggtgca     1860

agcgttaaac tgagctgtaa agcaagcggt tatatcttca ccagctatta tatgtactgg     1920

gtgaaacagg cacctggtca aggtctggaa tggattggtg aaattaatcc gagcaatggc     1980

gataccaact tcaacgaaaa attcaaaagc aaagcaaccc tgaccgttga taaaagcgca     2040

agcaccgcat atatggaact gagtagcctg cgtagcgaag ataccgcagt gtattattgt     2100

acccgtagtg atggtcgtaa tgatatggat agctggggtc agggcaccct ggttaccgtt     2160

agcagcgcaa gtaccaaagg tccgagcgtg tttccgctgg caccgagcag caaaagcacc     2220

agcggtggca ccgcagcact gggttgtctg gttaaagatt attttccgga accggttacc     2280

gtgagctgga atagtggtgc actgaccagt ggtgttcata cctttccggc agttctgcag     2340

agcagcggtc tgtatagcct gagcagtgtt gttaccgttc cgagcagtag cctgggcacc     2400

cagacctata tttgtaatgt taatcataag ccgagcaaca ccaaagtgga caaaaaagtt     2460

gaaccgaaaa gctgcgataa aacccatacc ggatctccgg ttccgcctac cggtgatagc     2520

gaagcaacac cggtgcctcc gaccggtgat tcagaaaccg caccggttcc accgacaggc     2580

gatagcggtg cacctcctgt tcctccaaca ggtgattctg gtgcccctcc ggtgccacca     2640

actggcgatt caggtgctcc gccagttccg ccaacgggtg acagtggtgc cccaccagta     2700

ccgcctacag gggatagtgg cgcaccgcca gtgccaccta caggtgactc aggcgcacca     2760

cctgtaccac cgactgggga ctcgggtgcg cctccagtac ctccgactgg tgacagcgga     2820

gcgccacctg tcccacctac gggtgattcc ggtgctccac cggtcccacc gactggtgat     2880

tctggcgcac cgcctgtccc tccgacaggc gacagtggcg caccaccggt tccaccaacc     2940

ggtgactcag gtgcgcctcc ggttcctcct acaggcgatt caggggcacc tccagtccca     3000

ccaacagggg atagcggagc cccaccagtt cctccgactg gggattcagg tgccccacct     3060

gttccaccga ccggtgatag tggtgctcca cctgtgcctc cgactggcga tagcggagcc     3120

cctccggttc cacctacagg tgacagtggt gcccctccgg ttcctccgac gggtgactcc     3180

ggtgcacctc cagttccacc tactggcgat agtggcgcac ctcctgtacc gcctactggc     3240

gacagcggtg ctccgcctgt accacctacc ggtgactctg gtgccccacc agtccctcca     3300

acgggtgata gcggtgctcc tccagtccct cctaccggtg attcgggtgc acctcctgtg     3360

ccacctacgg gtgacagcgg tgcaccacct gtgccaccaa ctggtgatgc cggtccgcca     3420

cctgtaccgc caaccggtga tagcggagcg cctcctgtac cgccaacagg ggattcaggc     3480

gctcctcctg tgacgccgac aggtgattcc gagacagccc ctgttccgcc aacaggcgac     3540

tcgggtgcac caccggttcc gcctacgggt gattcagaag cagctccggt tccgccaact     3600

gatgatagta aagaagcagg atcc                                            3624


<210>  100
<211>  374
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Half-life extending polypeptide, 34 units v1

<400>  100

Pro Val Pro Pro Thr Gly Asp Ser Glu Ala Thr Pro Val Pro Pro Thr 
1               5                   10                  15      


Gly Asp Ser Glu Thr Ala Pro Val Pro Pro Thr Gly Asp Ser Gly Ala 
            20                  25                  30          


Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro 
        35                  40                  45              


Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Gly 
    50                  55                  60                  


Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro 
65                  70                  75                  80  


Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser 
                85                  90                  95      


Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val 
            100                 105                 110         


Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp 
        115                 120                 125             


Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro 
    130                 135                 140                 


Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly 
145                 150                 155                 160 


Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro 
                165                 170                 175     


Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr 
            180                 185                 190         


Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala 
        195                 200                 205             


Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro 
    210                 215                 220                 


Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Gly 
225                 230                 235                 240 


Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro 
                245                 250                 255     


Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser 
            260                 265                 270         


Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val 
        275                 280                 285             


Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp 
    290                 295                 300                 


Ala Gly Pro Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro 
305                 310                 315                 320 


Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Thr Pro Thr Gly 
                325                 330                 335     


Asp Ser Glu Thr Ala Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro 
            340                 345                 350         


Pro Val Pro Pro Thr Gly Asp Ser Glu Ala Ala Pro Val Pro Pro Thr 
        355                 360                 365             


Asp Asp Ser Lys Glu Ala 
    370                 


<210>  101
<211>  374
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Half-life extending polypeptide, 34 units v2

<400>  101

Pro Val Pro Pro Thr Gly Asp Ser Glu Ala Thr Pro Val Pro Pro Thr 
1               5                   10                  15      


Gly Asp Ser Glu Thr Ala Pro Val Pro Pro Thr Gly Asp Ser Gly Ala 
            20                  25                  30          


Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro 
        35                  40                  45              


Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Gly 
    50                  55                  60                  


Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro 
65                  70                  75                  80  


Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser 
                85                  90                  95      


Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val 
            100                 105                 110         


Pro Pro Thr Gly Asp Ala Gly Pro Pro Pro Val Pro Pro Thr Gly Asp 
        115                 120                 125             


Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro 
    130                 135                 140                 


Val Thr Pro Thr Gly Asp Ser Glu Thr Ala Pro Val Pro Pro Thr Gly 
145                 150                 155                 160 


Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Glu Ala Ala 
                165                 170                 175     


Pro Val Pro Pro Thr Asp Asp Ser Lys Glu Ala Pro Val Pro Pro Thr 
            180                 185                 190         


Gly Asp Ser Glu Ala Thr Pro Val Pro Pro Thr Gly Asp Ser Glu Thr 
        195                 200                 205             


Ala Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro 
    210                 215                 220                 


Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Gly 
225                 230                 235                 240 


Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro 
                245                 250                 255     


Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser 
            260                 265                 270         


Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val 
        275                 280                 285             


Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp 
    290                 295                 300                 


Ala Gly Pro Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro 
305                 310                 315                 320 


Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Thr Pro Thr Gly 
                325                 330                 335     


Asp Ser Glu Thr Ala Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro 
            340                 345                 350         


Pro Val Pro Pro Thr Gly Asp Ser Glu Ala Ala Pro Val Pro Pro Thr 
        355                 360                 365             


Asp Asp Ser Lys Glu Ala 
    370                 


<210>  102
<211>  561
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Half-life extending polypeptide 51 units, v1

<400>  102

Pro Val Pro Pro Thr Gly Asp Ser Glu Ala Thr Pro Val Pro Pro Thr 
1               5                   10                  15      


Gly Asp Ser Glu Thr Ala Pro Val Pro Pro Thr Gly Asp Ser Gly Ala 
            20                  25                  30          


Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro 
        35                  40                  45              


Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Gly 
    50                  55                  60                  


Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro 
65                  70                  75                  80  


Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser 
                85                  90                  95      


Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val 
            100                 105                 110         


Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp 
        115                 120                 125             


Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro 
    130                 135                 140                 


Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly 
145                 150                 155                 160 


Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro 
                165                 170                 175     


Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr 
            180                 185                 190         


Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala 
        195                 200                 205             


Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro 
    210                 215                 220                 


Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Gly 
225                 230                 235                 240 


Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro 
                245                 250                 255     


Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser 
            260                 265                 270         


Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val 
        275                 280                 285             


Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp 
    290                 295                 300                 


Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro 
305                 310                 315                 320 


Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly 
                325                 330                 335     


Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro 
            340                 345                 350         


Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr 
        355                 360                 365             


Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala 
    370                 375                 380                 


Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro 
385                 390                 395                 400 


Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Gly 
                405                 410                 415     


Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro 
            420                 425                 430         


Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser 
        435                 440                 445             


Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val 
    450                 455                 460                 


Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp 
465                 470                 475                 480 


Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ala Gly Pro Pro Pro 
                485                 490                 495     


Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly 
            500                 505                 510         


Asp Ser Gly Ala Pro Pro Val Thr Pro Thr Gly Asp Ser Glu Thr Ala 
        515                 520                 525             


Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr 
    530                 535                 540                 


Gly Asp Ser Glu Ala Ala Pro Val Pro Pro Thr Asp Asp Ser Lys Glu 
545                 550                 555                 560 


Ala 
    


<210>  103
<211>  561
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Half-life extending polypeptide 51 units, v2

<400>  103

Pro Val Pro Pro Thr Gly Asp Ser Glu Ala Thr Pro Val Pro Pro Thr 
1               5                   10                  15      


Gly Asp Ser Glu Thr Ala Pro Val Pro Pro Thr Gly Asp Ser Gly Ala 
            20                  25                  30          


Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro 
        35                  40                  45              


Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Gly 
    50                  55                  60                  


Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro 
65                  70                  75                  80  


Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser 
                85                  90                  95      


Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val 
            100                 105                 110         


Pro Pro Thr Gly Asp Ala Gly Pro Pro Pro Val Pro Pro Thr Gly Asp 
        115                 120                 125             


Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro 
    130                 135                 140                 


Val Thr Pro Thr Gly Asp Ser Glu Thr Ala Pro Val Pro Pro Thr Gly 
145                 150                 155                 160 


Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Glu Ala Ala 
                165                 170                 175     


Pro Val Pro Pro Thr Asp Asp Ser Lys Glu Ala Pro Val Pro Pro Thr 
            180                 185                 190         


Gly Asp Ser Glu Ala Thr Pro Val Pro Pro Thr Gly Asp Ser Glu Thr 
        195                 200                 205             


Ala Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro 
    210                 215                 220                 


Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Gly 
225                 230                 235                 240 


Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro 
                245                 250                 255     


Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser 
            260                 265                 270         


Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val 
        275                 280                 285             


Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp 
    290                 295                 300                 


Ala Gly Pro Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro 
305                 310                 315                 320 


Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Thr Pro Thr Gly 
                325                 330                 335     


Asp Ser Glu Thr Ala Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro 
            340                 345                 350         


Pro Val Pro Pro Thr Gly Asp Ser Glu Ala Ala Pro Val Pro Pro Thr 
        355                 360                 365             


Asp Asp Ser Lys Glu Ala Pro Val Pro Pro Thr Gly Asp Ser Glu Ala 
    370                 375                 380                 


Thr Pro Val Pro Pro Thr Gly Asp Ser Glu Thr Ala Pro Val Pro Pro 
385                 390                 395                 400 


Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Gly 
                405                 410                 415     


Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro 
            420                 425                 430         


Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser 
        435                 440                 445             


Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val 
    450                 455                 460                 


Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp 
465                 470                 475                 480 


Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ala Gly Pro Pro Pro 
                485                 490                 495     


Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly 
            500                 505                 510         


Asp Ser Gly Ala Pro Pro Val Thr Pro Thr Gly Asp Ser Glu Thr Ala 
        515                 520                 525             


Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr 
    530                 535                 540                 


Gly Asp Ser Glu Ala Ala Pro Val Pro Pro Thr Asp Asp Ser Lys Glu 
545                 550                 555                 560 


Ala 
    


<210>  104
<211>  748
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Half-life extending polypeptide 68 units, v1

<400>  104

Pro Val Pro Pro Thr Gly Asp Ser Glu Ala Thr Pro Val Pro Pro Thr 
1               5                   10                  15      


Gly Asp Ser Glu Thr Ala Pro Val Pro Pro Thr Gly Asp Ser Gly Ala 
            20                  25                  30          


Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro 
        35                  40                  45              


Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Gly 
    50                  55                  60                  


Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro 
65                  70                  75                  80  


Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser 
                85                  90                  95      


Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val 
            100                 105                 110         


Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp 
        115                 120                 125             


Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro 
    130                 135                 140                 


Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly 
145                 150                 155                 160 


Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro 
                165                 170                 175     


Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr 
            180                 185                 190         


Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala 
        195                 200                 205             


Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro 
    210                 215                 220                 


Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Gly 
225                 230                 235                 240 


Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro 
                245                 250                 255     


Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser 
            260                 265                 270         


Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val 
        275                 280                 285             


Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp 
    290                 295                 300                 


Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro 
305                 310                 315                 320 


Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly 
                325                 330                 335     


Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro 
            340                 345                 350         


Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr 
        355                 360                 365             


Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala 
    370                 375                 380                 


Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro 
385                 390                 395                 400 


Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Gly 
                405                 410                 415     


Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro 
            420                 425                 430         


Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser 
        435                 440                 445             


Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val 
    450                 455                 460                 


Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp 
465                 470                 475                 480 


Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro 
                485                 490                 495     


Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly 
            500                 505                 510         


Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro 
        515                 520                 525             


Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr 
    530                 535                 540                 


Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala 
545                 550                 555                 560 


Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro 
                565                 570                 575     


Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Gly 
            580                 585                 590         


Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro 
        595                 600                 605             


Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser 
    610                 615                 620                 


Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val 
625                 630                 635                 640 


Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp 
                645                 650                 655     


Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro 
            660                 665                 670         


Val Pro Pro Thr Gly Asp Ala Gly Pro Pro Pro Val Pro Pro Thr Gly 
        675                 680                 685             


Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro 
    690                 695                 700                 


Pro Val Thr Pro Thr Gly Asp Ser Glu Thr Ala Pro Val Pro Pro Thr 
705                 710                 715                 720 


Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Glu Ala 
                725                 730                 735     


Ala Pro Val Pro Pro Thr Asp Asp Ser Lys Glu Ala 
            740                 745             


<210>  105
<211>  748
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Half-life extending polypeptide 68 units, v2

<400>  105

Pro Val Pro Pro Thr Gly Asp Ser Glu Ala Thr Pro Val Pro Pro Thr 
1               5                   10                  15      


Gly Asp Ser Glu Thr Ala Pro Val Pro Pro Thr Gly Asp Ser Gly Ala 
            20                  25                  30          


Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro 
        35                  40                  45              


Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Gly 
    50                  55                  60                  


Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro 
65                  70                  75                  80  


Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser 
                85                  90                  95      


Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val 
            100                 105                 110         


Pro Pro Thr Gly Asp Ala Gly Pro Pro Pro Val Pro Pro Thr Gly Asp 
        115                 120                 125             


Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro 
    130                 135                 140                 


Val Thr Pro Thr Gly Asp Ser Glu Thr Ala Pro Val Pro Pro Thr Gly 
145                 150                 155                 160 


Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Glu Ala Ala 
                165                 170                 175     


Pro Val Pro Pro Thr Asp Asp Ser Lys Glu Ala Pro Val Pro Pro Thr 
            180                 185                 190         


Gly Asp Ser Glu Ala Thr Pro Val Pro Pro Thr Gly Asp Ser Glu Thr 
        195                 200                 205             


Ala Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro 
    210                 215                 220                 


Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Gly 
225                 230                 235                 240 


Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro 
                245                 250                 255     


Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser 
            260                 265                 270         


Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val 
        275                 280                 285             


Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp 
    290                 295                 300                 


Ala Gly Pro Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro 
305                 310                 315                 320 


Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Thr Pro Thr Gly 
                325                 330                 335     


Asp Ser Glu Thr Ala Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro 
            340                 345                 350         


Pro Val Pro Pro Thr Gly Asp Ser Glu Ala Ala Pro Val Pro Pro Thr 
        355                 360                 365             


Asp Asp Ser Lys Glu Ala Pro Val Pro Pro Thr Gly Asp Ser Glu Ala 
    370                 375                 380                 


Thr Pro Val Pro Pro Thr Gly Asp Ser Glu Thr Ala Pro Val Pro Pro 
385                 390                 395                 400 


Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Gly 
                405                 410                 415     


Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro 
            420                 425                 430         


Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser 
        435                 440                 445             


Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val 
    450                 455                 460                 


Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp 
465                 470                 475                 480 


Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ala Gly Pro Pro Pro 
                485                 490                 495     


Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly 
            500                 505                 510         


Asp Ser Gly Ala Pro Pro Val Thr Pro Thr Gly Asp Ser Glu Thr Ala 
        515                 520                 525             


Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr 
    530                 535                 540                 


Gly Asp Ser Glu Ala Ala Pro Val Pro Pro Thr Asp Asp Ser Lys Glu 
545                 550                 555                 560 


Ala Pro Val Pro Pro Thr Gly Asp Ser Glu Ala Thr Pro Val Pro Pro 
                565                 570                 575     


Thr Gly Asp Ser Glu Thr Ala Pro Val Pro Pro Thr Gly Asp Ser Gly 
            580                 585                 590         


Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro 
        595                 600                 605             


Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser 
    610                 615                 620                 


Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val 
625                 630                 635                 640 


Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp 
                645                 650                 655     


Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro 
            660                 665                 670         


Val Pro Pro Thr Gly Asp Ala Gly Pro Pro Pro Val Pro Pro Thr Gly 
        675                 680                 685             


Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro 
    690                 695                 700                 


Pro Val Thr Pro Thr Gly Asp Ser Glu Thr Ala Pro Val Pro Pro Thr 
705                 710                 715                 720 


Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Glu Ala 
                725                 730                 735     


Ala Pro Val Pro Pro Thr Asp Asp Ser Lys Glu Ala 
            740                 745             


