               SEQUENCE LISTING

<110> Merz Pharma GmbH & Co. KGaA

<120> NOVEL RECOMBINANT BOTULINUM TOXIN WITH INCREASED DURATION OF EFFECT

<130> 0117-000-PCT

<160> 6

<170> BiSSAP 1.3.6

<210> 1
<211> 100
<212> PRT
<213> Artificial Sequence


<220> 
<223> PASTGE100

<400> 1
Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser 
1               5                   10                  15      
Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly 
            20                  25                  30          
Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly 
        35                  40                  45              
Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu 
    50                  55                  60                  
Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu 
65                  70                  75                  80  
Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly 
                85                  90                  95      
Ser Glu Pro Ala 
            100 

<210> 2
<211> 200
<212> PRT
<213> Artificial Sequence


<220> 
<223> PASTGE200

<400> 2
Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser 
1               5                   10                  15      
Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly 
            20                  25                  30          
Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly 
        35                  40                  45              
Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu 
    50                  55                  60                  
Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu 
65                  70                  75                  80  
Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly 
                85                  90                  95      
Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Pro Ala Gly 
            100                 105                 110         
Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr Pro Glu 
        115                 120                 125             
Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly 
    130                 135                 140                 
Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro Ala Gly 
145                 150                 155                 160 
Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Glu Gly 
                165                 170                 175     
Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly 
            180                 185                 190         
Thr Ser Glu Ser Ala Thr Pro Glu 
        195                 200 

<210> 3
<211> 4935
<212> DNA
<213> Artificial Sequence


<220> 
<223> PASTGE100-BoNT/A- PASTGE 200

<400> 3
atgggtagca gccatcatca tcaccatcat ggtagcctgg ttccgcgtag ctcttctccg       60

gctgggtctc caacatcgac tgaagagggt acgtctgaga gtgctacacc cgagagcggt      120

ccaggcacat ccacggagcc atccgaaggg tcagcgcccg gaagcccggc gggttccccg      180

acatcgactg aggagggcac ctcaacagaa cctagcgagg gtagtgcacc ggggaccagc      240

actgagccct ccgaaggctc cgcgccaggg acaagtgagt ccgcaacgcc agagagcggc      300

ccaggcagcg agcctgccac gagtgggtca gagacgccgg ggtcagaacc tgcgccattt      360

gtgaacaagc agtttaacta taaggacccg gtgaacggtg tggatatcgc gtatatcaaa      420

atcccgaatg cgggccagat gcaaccagtc aaggcgttca agattcataa caagatttgg      480

gttattccgg aacgtgatac cttcaccaat ccggaagaag gcgatttaaa tccgccgcca      540

gaagccaaac aagtgccggt gagctactat gatagcacgt atcttagcac cgataatgaa      600

aaagacaatt acctgaaggg cgtgaccaag ttgttcgagc gcatctacag taccgactta      660

ggccgcatgt tgttgacgag catcgttcgc ggtatcccgt tctggggcgg ctcgaccatt      720

gataccgagt tgaaagtcat tgacacgaac tgtatcaatg ttatccaacc ggacggcagt      780

tatcgcagcg aggagttaaa tttggtcatc atcggtccaa gcgcagatat tattcagttc      840

gaatgcaaga gcttcggcca tgaggtcttg aatttgacgc gcaacggtta cggcagcacc      900

caatacatcc gctttagccc ggatttcacc tttggcttcg aggagagctt ggaggtggac      960

accaacccgc tgttaggtgc cggcaaattc gcaaccgacc cggcagtgac gttggcgcac     1020

gaattgattc atgcgggtca ccgcttatac ggtatcgcga tcaatccgaa tcgcgtcttt     1080

aaagtcaata ccaacgcgta ctacgaaatg agcggcttag aggttagctt tgaagaatta     1140

cgcaccttcg gtggccacga cgccaagttc atcgacagcc tgcaggaaaa tgagttccgc     1200

ttgtactatt acaataaatt caaggacatc gcgagcacct taaataaagc aaagagcatt     1260

gtgggcacca ccgcaagctt gcagtacatg aagaacgtat ttaaggaaaa atatttgttg     1320

tcggaggata ccagcgggaa attcagcgtc gataagctga aattcgacaa attgtataaa     1380

atgctgaccg agatttacac cgaggataac ttcgtcaagt tttttaaggt gttaaatcgt     1440

aagacctatt taaactttga taaagcggtg tttaaaatta atatcgtgcc gaaggtgaat     1500

tacaccatct acgatggttt caatttacgc aacacgaatc tggcggcgaa ttttaatggc     1560

caaaacaccg aaattaacaa catgaacttt acgaagttaa agaatttcac gggcttattc     1620

gaattctaca agttattatg cgtgcgcggc atcattacca gcaaggcagg tgcgggcaag     1680

tccttggttc cgcgtggcag cgccggcgcc ggcgcgctca atgatctgtg tattaaagtc     1740

aataactggg acctgttctt cagcccgagc gaggataact ttaccaacga cttaaacaaa     1800

ggcgaggaga tcacgagcga tacgaacatc gaggcggcgg aggaaaatat tagcctggac     1860

ctcattcagc agtactatct gacgttcaat tttgacaatg agccggagaa catcagcatt     1920

gaaaatctca gcagcgacat catcggtcag ttggaactga tgccgaacat tgaacgcttt     1980

ccgaacggca aaaaatatga actggacaag tataccatgt tccattactt acgcgcacag     2040

gaatttgagc acggcaagag ccgcattgcg ctgaccaata gcgttaacga ggccttgtta     2100

aatccgagcc gtgtctacac gttcttcagc agcgattatg tcaaaaaagt gaacaaggcg     2160

accgaagccg cgatgttttt gggctgggtc gagcaattgg tttacgattt taccgacgaa     2220

accagcgagg tgagcacgac cgacaaaatt gcagatatca ccatcatcat tccgtacatc     2280

ggtccggcgc tcaatatcgg caatatgtta tacaaggacg actttgtggg cgcgctgatc     2340

tttagcggcg cggttatctt attagaattc atcccggaga tcgcaatccc ggtcttgggc     2400

acctttgcgt tggtgagcta tatcgcgaat aaagtgctca cggtccaaac catcgataac     2460

gcgctcagca agcgtaatga gaaatgggac gaggtttata agtatatcgt gaccaactgg     2520

ttagcaaaag tcaatacgca gatcgatctc atccgcaaaa aaatgaaaga agccttggaa     2580

aatcaagcgg aggcaaccaa agccatcatt aattaccagt ataaccaata taccgaagaa     2640

gaaaaaaaca atatcaactt caatatcgat gatttgagca gcaaactgaa cgagagcatt     2700

aacaaagcga tgattaacat caacaagttc ttgaatcaat gcagcgtgag ctatctcatg     2760

aacagcatga tcccgtatgg cgtcaaacgc ttggaagatt ttgacgccag cctgaaagat     2820

gcgctcctca agtatattta tgacaaccgc ggcaccctca ttggccaggt ggaccgcttg     2880

aaggataaag tgaacaatac gctcagcacg gatatcccgt tccagctgag caagtacgtc     2940

gacaaccagc gcttactgag cacctttacc gagtatatca agaacatcat taataccagc     3000

atcctcaact tgcgctatga gagcaatcac ctgatcgacc tcagccgcta cgccagcaag     3060

atcaacatcg gcagcaaggt caatttcgac ccgatcgata agaatcagat ccaattgttt     3120

aacctggaaa gcagcaagat cgaggttatc ttgaagaacg cgattgtgta caacagcatg     3180

tacgagaact ttagcacgag cttctggatt cgtatcccga agtatttcaa tagcattagc     3240

ctgaataacg aatataccat tatcaactgc atggaaaata atagcggctg gaaggtgagc     3300

ttaaattacg gcgagatcat ttggacctta caggataccc aagaaatcaa acagcgcgtc     3360

gtctttaagt atagccagat gatcaacatc agcgattaca tcaaccgctg gatcttcgtg     3420

accatcacca ataatcgctt gaataatagc aagatttaca tcaatggtcg cttgattgat     3480

caaaaaccga tcagcaatct cggtaatatc catgccagca ataacatcat gtttaagtta     3540

gacggttgcc gcgataccca ccgctatatc tggatcaagt attttaactt atttgataag     3600

gaactcaacg aaaaggaaat taaagactta tatgacaatc agagcaatag cggcatcctg     3660

aaggatttct ggggcgacta cctgcagtac gataagccgt actatatgtt gaacttgtat     3720

gacccgaaca aatatgtcga tgtgaacaat gtgggtattc gtggctatat gtacttaaag     3780

ggcccgcgtg gtagcgtgat gaccacgaat atttacttaa acagcagctt ataccgcggc     3840

acgaagttta ttatcaagaa gtatgccagc ggcaacaagg acaatatcgt ccgcaacaac     3900

gaccgtgtgt atattaacgt ggtggtgaag aataaagagt accgcttggc cacgaatgcg     3960

agccaggcgg gcgtggaaaa aatcttgagc gcgttggaga tcccggacgt cggcaacctc     4020

agccaggttg tggtgatgaa gtctaaaaac gaccagggca tcacgaacaa gtgcaaaatg     4080

aatttgcaag ataacaacgg caacgacatc ggctttattg gttttcacca gttcaataac     4140

atcgccaaac tcgtggccag caattggtat aaccgccaaa ttgaacgcag cagccgcacg     4200

ctcggctgta gctgggagtt catcccggtg gacgatggct ggggcgagcg cccgctctct     4260

ccggcgggtt ctccgacctc taccgaagaa ggtacctctg aatctgcgac cccggaatct     4320

ggtccgggta cctctaccga accgtctgaa ggttctgcgc cgggttctcc ggcgggttct     4380

ccgacctcta ccgaagaagg tacctctacc gaaccgtctg aaggttctgc gccgggtacc     4440

tctaccgaac cgtctgaagg ttctgcgccg ggtacctctg aatctgcgac cccggaatct     4500

ggtccgggtt ctgaaccggc gacctctggt tctgaaaccc cgggttctga accggcgacc     4560

tctggttctg aaaccccggg ttctccggcg ggttctccga cctctaccga agaaggtacc     4620

tctgaatctg cgaccccgga atctggtccg ggtacctcta ccgaaccgtc tgaaggttct     4680

gcgccgggta cctctaccga accgtctgaa ggttctgcgc cgggttctcc ggcgggttct     4740

ccgacctcta ccgaagaagg tacctctacc gaaccgtctg aaggttctgc gccgggtacc     4800

tctaccgaac cgtctgaagg ttctgcgccg ggtacctctg aatctgcgac cccggaagga     4860

gatctggtgc cacgcggttc cgcgaattcg agctccgtcg acaagctttg gagccacccg     4920

cagttcgaaa aataa                                                      4935


<210> 4
<211> 1644
<212> PRT
<213> Artificial Sequence


<220> 
<223> PASTGE100-BoNT/A- PASTGE 200

<400> 4
Met Gly Ser Ser His His His His His His Gly Ser Leu Val Pro Arg 
1               5                   10                  15      
Ser Ser Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser 
            20                  25                  30          
Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser 
        35                  40                  45              
Glu Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu 
    50                  55                  60                  
Glu Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser 
65                  70                  75                  80  
Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr 
                85                  90                  95      
Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr 
            100                 105                 110         
Pro Gly Ser Glu Pro Ala Pro Phe Val Asn Lys Gln Phe Asn Tyr Lys 
        115                 120                 125             
Asp Pro Val Asn Gly Val Asp Ile Ala Tyr Ile Lys Ile Pro Asn Ala 
    130                 135                 140                 
Gly Gln Met Gln Pro Val Lys Ala Phe Lys Ile His Asn Lys Ile Trp 
145                 150                 155                 160 
Val Ile Pro Glu Arg Asp Thr Phe Thr Asn Pro Glu Glu Gly Asp Leu 
                165                 170                 175     
Asn Pro Pro Pro Glu Ala Lys Gln Val Pro Val Ser Tyr Tyr Asp Ser 
            180                 185                 190         
Thr Tyr Leu Ser Thr Asp Asn Glu Lys Asp Asn Tyr Leu Lys Gly Val 
        195                 200                 205             
Thr Lys Leu Phe Glu Arg Ile Tyr Ser Thr Asp Leu Gly Arg Met Leu 
    210                 215                 220                 
Leu Thr Ser Ile Val Arg Gly Ile Pro Phe Trp Gly Gly Ser Thr Ile 
225                 230                 235                 240 
Asp Thr Glu Leu Lys Val Ile Asp Thr Asn Cys Ile Asn Val Ile Gln 
                245                 250                 255     
Pro Asp Gly Ser Tyr Arg Ser Glu Glu Leu Asn Leu Val Ile Ile Gly 
            260                 265                 270         
Pro Ser Ala Asp Ile Ile Gln Phe Glu Cys Lys Ser Phe Gly His Glu 
        275                 280                 285             
Val Leu Asn Leu Thr Arg Asn Gly Tyr Gly Ser Thr Gln Tyr Ile Arg 
    290                 295                 300                 
Phe Ser Pro Asp Phe Thr Phe Gly Phe Glu Glu Ser Leu Glu Val Asp 
305                 310                 315                 320 
Thr Asn Pro Leu Leu Gly Ala Gly Lys Phe Ala Thr Asp Pro Ala Val 
                325                 330                 335     
Thr Leu Ala His Glu Leu Ile His Ala Gly His Arg Leu Tyr Gly Ile 
            340                 345                 350         
Ala Ile Asn Pro Asn Arg Val Phe Lys Val Asn Thr Asn Ala Tyr Tyr 
        355                 360                 365             
Glu Met Ser Gly Leu Glu Val Ser Phe Glu Glu Leu Arg Thr Phe Gly 
    370                 375                 380                 
Gly His Asp Ala Lys Phe Ile Asp Ser Leu Gln Glu Asn Glu Phe Arg 
385                 390                 395                 400 
Leu Tyr Tyr Tyr Asn Lys Phe Lys Asp Ile Ala Ser Thr Leu Asn Lys 
                405                 410                 415     
Ala Lys Ser Ile Val Gly Thr Thr Ala Ser Leu Gln Tyr Met Lys Asn 
            420                 425                 430         
Val Phe Lys Glu Lys Tyr Leu Leu Ser Glu Asp Thr Ser Gly Lys Phe 
        435                 440                 445             
Ser Val Asp Lys Leu Lys Phe Asp Lys Leu Tyr Lys Met Leu Thr Glu 
    450                 455                 460                 
Ile Tyr Thr Glu Asp Asn Phe Val Lys Phe Phe Lys Val Leu Asn Arg 
465                 470                 475                 480 
Lys Thr Tyr Leu Asn Phe Asp Lys Ala Val Phe Lys Ile Asn Ile Val 
                485                 490                 495     
Pro Lys Val Asn Tyr Thr Ile Tyr Asp Gly Phe Asn Leu Arg Asn Thr 
            500                 505                 510         
Asn Leu Ala Ala Asn Phe Asn Gly Gln Asn Thr Glu Ile Asn Asn Met 
        515                 520                 525             
Asn Phe Thr Lys Leu Lys Asn Phe Thr Gly Leu Phe Glu Phe Tyr Lys 
    530                 535                 540                 
Leu Leu Cys Val Arg Gly Ile Ile Thr Ser Lys Ala Gly Ala Gly Lys 
545                 550                 555                 560 
Ser Leu Val Pro Arg Gly Ser Ala Gly Ala Gly Ala Leu Asn Asp Leu 
                565                 570                 575     
Cys Ile Lys Val Asn Asn Trp Asp Leu Phe Phe Ser Pro Ser Glu Asp 
            580                 585                 590         
Asn Phe Thr Asn Asp Leu Asn Lys Gly Glu Glu Ile Thr Ser Asp Thr 
        595                 600                 605             
Asn Ile Glu Ala Ala Glu Glu Asn Ile Ser Leu Asp Leu Ile Gln Gln 
    610                 615                 620                 
Tyr Tyr Leu Thr Phe Asn Phe Asp Asn Glu Pro Glu Asn Ile Ser Ile 
625                 630                 635                 640 
Glu Asn Leu Ser Ser Asp Ile Ile Gly Gln Leu Glu Leu Met Pro Asn 
                645                 650                 655     
Ile Glu Arg Phe Pro Asn Gly Lys Lys Tyr Glu Leu Asp Lys Tyr Thr 
            660                 665                 670         
Met Phe His Tyr Leu Arg Ala Gln Glu Phe Glu His Gly Lys Ser Arg 
        675                 680                 685             
Ile Ala Leu Thr Asn Ser Val Asn Glu Ala Leu Leu Asn Pro Ser Arg 
    690                 695                 700                 
Val Tyr Thr Phe Phe Ser Ser Asp Tyr Val Lys Lys Val Asn Lys Ala 
705                 710                 715                 720 
Thr Glu Ala Ala Met Phe Leu Gly Trp Val Glu Gln Leu Val Tyr Asp 
                725                 730                 735     
Phe Thr Asp Glu Thr Ser Glu Val Ser Thr Thr Asp Lys Ile Ala Asp 
            740                 745                 750         
Ile Thr Ile Ile Ile Pro Tyr Ile Gly Pro Ala Leu Asn Ile Gly Asn 
        755                 760                 765             
Met Leu Tyr Lys Asp Asp Phe Val Gly Ala Leu Ile Phe Ser Gly Ala 
    770                 775                 780                 
Val Ile Leu Leu Glu Phe Ile Pro Glu Ile Ala Ile Pro Val Leu Gly 
785                 790                 795                 800 
Thr Phe Ala Leu Val Ser Tyr Ile Ala Asn Lys Val Leu Thr Val Gln 
                805                 810                 815     
Thr Ile Asp Asn Ala Leu Ser Lys Arg Asn Glu Lys Trp Asp Glu Val 
            820                 825                 830         
Tyr Lys Tyr Ile Val Thr Asn Trp Leu Ala Lys Val Asn Thr Gln Ile 
        835                 840                 845             
Asp Leu Ile Arg Lys Lys Met Lys Glu Ala Leu Glu Asn Gln Ala Glu 
    850                 855                 860                 
Ala Thr Lys Ala Ile Ile Asn Tyr Gln Tyr Asn Gln Tyr Thr Glu Glu 
865                 870                 875                 880 
Glu Lys Asn Asn Ile Asn Phe Asn Ile Asp Asp Leu Ser Ser Lys Leu 
                885                 890                 895     
Asn Glu Ser Ile Asn Lys Ala Met Ile Asn Ile Asn Lys Phe Leu Asn 
            900                 905                 910         
Gln Cys Ser Val Ser Tyr Leu Met Asn Ser Met Ile Pro Tyr Gly Val 
        915                 920                 925             
Lys Arg Leu Glu Asp Phe Asp Ala Ser Leu Lys Asp Ala Leu Leu Lys 
    930                 935                 940                 
Tyr Ile Tyr Asp Asn Arg Gly Thr Leu Ile Gly Gln Val Asp Arg Leu 
945                 950                 955                 960 
Lys Asp Lys Val Asn Asn Thr Leu Ser Thr Asp Ile Pro Phe Gln Leu 
                965                 970                 975     
Ser Lys Tyr Val Asp Asn Gln Arg Leu Leu Ser Thr Phe Thr Glu Tyr 
            980                 985                 990         
Ile Lys Asn Ile Ile Asn Thr Ser Ile Leu Asn Leu Arg Tyr Glu Ser 
        995                 1000                1005            
Asn His Leu Ile Asp Leu Ser Arg Tyr Ala Ser Lys Ile Asn Ile Gly 
    1010                1015                1020                
Ser Lys Val Asn Phe Asp Pro Ile Asp Lys Asn Gln Ile Gln Leu Phe 
1025                1030                1035                1040
Asn Leu Glu Ser Ser Lys Ile Glu Val Ile Leu Lys Asn Ala Ile Val 
                1045                1050                1055    
Tyr Asn Ser Met Tyr Glu Asn Phe Ser Thr Ser Phe Trp Ile Arg Ile 
            1060                1065                1070        
Pro Lys Tyr Phe Asn Ser Ile Ser Leu Asn Asn Glu Tyr Thr Ile Ile 
        1075                1080                1085            
Asn Cys Met Glu Asn Asn Ser Gly Trp Lys Val Ser Leu Asn Tyr Gly 
    1090                1095                1100                
Glu Ile Ile Trp Thr Leu Gln Asp Thr Gln Glu Ile Lys Gln Arg Val 
1105                1110                1115                1120
Val Phe Lys Tyr Ser Gln Met Ile Asn Ile Ser Asp Tyr Ile Asn Arg 
                1125                1130                1135    
Trp Ile Phe Val Thr Ile Thr Asn Asn Arg Leu Asn Asn Ser Lys Ile 
            1140                1145                1150        
Tyr Ile Asn Gly Arg Leu Ile Asp Gln Lys Pro Ile Ser Asn Leu Gly 
        1155                1160                1165            
Asn Ile His Ala Ser Asn Asn Ile Met Phe Lys Leu Asp Gly Cys Arg 
    1170                1175                1180                
Asp Thr His Arg Tyr Ile Trp Ile Lys Tyr Phe Asn Leu Phe Asp Lys 
1185                1190                1195                1200
Glu Leu Asn Glu Lys Glu Ile Lys Asp Leu Tyr Asp Asn Gln Ser Asn 
                1205                1210                1215    
Ser Gly Ile Leu Lys Asp Phe Trp Gly Asp Tyr Leu Gln Tyr Asp Lys 
            1220                1225                1230        
Pro Tyr Tyr Met Leu Asn Leu Tyr Asp Pro Asn Lys Tyr Val Asp Val 
        1235                1240                1245            
Asn Asn Val Gly Ile Arg Gly Tyr Met Tyr Leu Lys Gly Pro Arg Gly 
    1250                1255                1260                
Ser Val Met Thr Thr Asn Ile Tyr Leu Asn Ser Ser Leu Tyr Arg Gly 
1265                1270                1275                1280
Thr Lys Phe Ile Ile Lys Lys Tyr Ala Ser Gly Asn Lys Asp Asn Ile 
                1285                1290                1295    
Val Arg Asn Asn Asp Arg Val Tyr Ile Asn Val Val Val Lys Asn Lys 
            1300                1305                1310        
Glu Tyr Arg Leu Ala Thr Asn Ala Ser Gln Ala Gly Val Glu Lys Ile 
        1315                1320                1325            
Leu Ser Ala Leu Glu Ile Pro Asp Val Gly Asn Leu Ser Gln Val Val 
    1330                1335                1340                
Val Met Lys Ser Lys Asn Asp Gln Gly Ile Thr Asn Lys Cys Lys Met 
1345                1350                1355                1360
Asn Leu Gln Asp Asn Asn Gly Asn Asp Ile Gly Phe Ile Gly Phe His 
                1365                1370                1375    
Gln Phe Asn Asn Ile Ala Lys Leu Val Ala Ser Asn Trp Tyr Asn Arg 
            1380                1385                1390        
Gln Ile Glu Arg Ser Ser Arg Thr Leu Gly Cys Ser Trp Glu Phe Ile 
        1395                1400                1405            
Pro Val Asp Asp Gly Trp Gly Glu Arg Pro Leu Ser Pro Ala Gly Ser 
    1410                1415                1420                
Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser 
1425                1430                1435                1440
Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser 
                1445                1450                1455    
Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro 
            1460                1465                1470        
Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser 
        1475                1480                1485            
Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser 
    1490                1495                1500                
Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Glu Pro Ala Thr 
1505                1510                1515                1520
Ser Gly Ser Glu Thr Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr 
                1525                1530                1535    
Glu Glu Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr 
            1540                1545                1550        
Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro 
        1555                1560                1565            
Ser Glu Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr 
    1570                1575                1580                
Glu Glu Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr 
1585                1590                1595                1600
Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala 
                1605                1610                1615    
Thr Pro Glu Gly Asp Leu Val Pro Arg Gly Ser Ala Asn Ser Ser Ser 
            1620                1625                1630        
Val Asp Lys Leu Trp Ser His Pro Gln Phe Glu Lys 
        1635                1640                

<210> 5
<211> 300
<212> DNA
<213> Artificial Sequence


<220> 
<223> PASTGE100

<400> 5
tctccggctg ggtctccaac atcgactgaa gagggtacgt ctgagagtgc tacacccgag     60

agcggtccag gcacatccac ggagccatcc gaagggtcag cgcccggaag cccggcgggt    120

tccccgacat cgactgagga gggcacctca acagaaccta gcgagggtag tgcaccgggg    180

accagcactg agccctccga aggctccgcg ccagggacaa gtgagtccgc aacgccagag    240

agcggcccag gcagcgagcc tgccacgagt gggtcagaga cgccggggtc agaacctgcg    300


<210> 6
<211> 600
<212> DNA
<213> Artificial Sequence


<220> 
<223> PASTGE200

<400> 6
tctccggcgg gttctccgac ctctaccgaa gaaggtacct ctgaatctgc gaccccggaa      60

tctggtccgg gtacctctac cgaaccgtct gaaggttctg cgccgggttc tccggcgggt     120

tctccgacct ctaccgaaga aggtacctct accgaaccgt ctgaaggttc tgcgccgggt     180

acctctaccg aaccgtctga aggttctgcg ccgggtacct ctgaatctgc gaccccggaa     240

tctggtccgg gttctgaacc ggcgacctct ggttctgaaa ccccgggttc tgaaccggcg     300

acctctggtt ctgaaacccc gggttctccg gcgggttctc cgacctctac cgaagaaggt     360

acctctgaat ctgcgacccc ggaatctggt ccgggtacct ctaccgaacc gtctgaaggt     420

tctgcgccgg gtacctctac cgaaccgtct gaaggttctg cgccgggttc tccggcgggt     480

tctccgacct ctaccgaaga aggtacctct accgaaccgt ctgaaggttc tgcgccgggt     540

acctctaccg aaccgtctga aggttctgcg ccgggtacct ctgaatctgc gaccccggaa     600


