    

<110> Ĵҩҵι˾
<120> װĿ-żtdcżλɸѡ
<160> 44

<210> 1
<211> 348
<212> DNA
<213> 2A1ɱVHDNA

<400> 1

gatgtgcagc ttcaggagtc gggacctagc ctggtgaaac cttctcagtc tctgtccctc       60

acctgcactg tcactggcta ctcaatcacc agtgattttg cctggaactg gattcggcag      120

tttccaggaa acaagctgga gtggatgggc tacataagtt atagtggtaa cactaggtac      180

aacccatctc tcaaaagtcg aatctctatc actcgcgaca catccaagaa ccaattcttc      240

ctgcagttga actctgtgac tattgaggac acagccacat attactgtgt aacggcggga      300

cgcgggtttc cttattgggg ccaagggact ctggtcactg tctctgca                   348





<210> 2
<211> 125
<212> PRT
<213> 2A1ɱVH

<400> 2

DVQLQESGPS LVKPSQSLSL TCTVTGYSIT SDFAWNWIRQ FPGNKLEWMG YISYSGNTRY        60
NPSLKCDRCD RSRISITRDT SKNQFFLQLN SVTIEDTATY YCVTAGRGFP YWGQGTLVTV       120
SACDR                                                                   125

<210> 6
<211> 324
<212> DNA
<213> 2A1ɱVLDNA

<400> 1

gacatcctga tgacccaatc tccatcctcc atgtctgtat ctctgggaga cacagtcagc        60
atcacttgcc attcaagtca ggacattaac agtaatatag ggtggttgca gcagagacca       120
gggaaatcat ttaagggcct gatctatcat ggaaccaact tggacgatga agttccatca       180
aggttcagtg gcagtggatc tggagccgat tattctctca ccatcagcag cctggaatct       240
gaagattttg cagactatta ctgtgtacag tatgctcagt ttccgtggac gttcggtgga       300
ggcaccaagc tggaaatcaa acgt                                              324

<210> 7
<211> 117
<212> PRT
<213> 2A1ɱVL

<400> 2

DILMTQSPSS MSVSLGDTVS ITCHSSQDIN SNIGWLQQRP GKSFKGLIYH GTNLDDEVPS        60
RFSGSCDRCD RGSGADYSLT ISSLESEDFA DYYCVQYAQF PWTFGGGTKL EIKRCDR          117


<210> 11
<211> 990
<212> DNA
<213> 2A1㶨CHDNA

<400> 1

gctagcacca agggcccatc ggtcttcccc ctggcaccct cctccaagag cacctctggg       60

ggcacagcgg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg      120

tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca      180

ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacccagacc      240

tacatctgca acgtgaatca caagcccagc aacaccaagg tggacaagag agttgagccc      300

aaatcttgtg acaaaactca cacatgccca ccgtgcccag cacctgaact cctgggggga      360

ccgtcagtct tcctcttccc cccaaaaccc aaggacaccc tcatgatctc ccggacccct      420

gaggtcacat gcgtggtggt ggacgtgagc cacgaagacc ctgaggtcaa gttcaactgg      480

tacgtggacg gcgtggaggt gcataatgcc aagacaaagc cgcgggagga gcagtacaac      540

agcacgtacc gtgtggtcag cgtcctcacc gtcctgcacc aggactggct gaatggcaag      600

gagtacaagt gcaaggtctc caacaaagcc ctcccagccc ccatcgagaa aaccatctcc      660

aaagccaaag ggcagccccg agaaccacag gtgtacaccc tgcccccatc ccgggatgag      720

ctgaccaaga accaggtcag cctgacctgc ctggtcaaag gcttctatcc cagcgacatc      780

gccgtggagt gggagagcaa tgggcagccg gagaacaact acaagaccac gcctcccgtg      840

ctggactccg acggctcctt cttcctctat agcaagctca ccgtggacaa gagcaggtgg      900

cagcagggga acgtcttctc atgctccgtg atgcatgagg ctctgcacaa ccactacacg      960

cagaagagcc tctccctgtc tccgggtaaa                                       990

<210> 12
<211> 330
<212> PRT
<213> 2A1㶨CH

<400> 2

ASTKGPSVFP LAPSSKSTSG GTAALGCLVK DYFPEPVTVS WNSGALTSGV HTFPAVLQSS        60
GLYSLSSVVT VPSSSLGTQT YICNVNHKPS NTKVDKRVEP KSCDKTHTCP PCPAPELLGG       120
PSVFLFPPKP KDTLMISRTP EVTCVVVDVS HEDPEVKFNW YVDGVEVHNA KTKPREEQYN       180
STYRVVSVLT VLHQDWLNGK EYKCKVSNKA LPAPIEKTIS KAKGQPREPQ VYTLPPSRDE       240
LTKNQVSLTC LVKGFYPSDI AVEWESNGQP ENNYKTTPPV LDSDGSFFLY SKLTVDKSRW       300
QQGNVFSCSV MHEALHNHYT QKSLSLSPGK                                        330


<210> 13
<211> 321
<212> DNA
<213> 2A1㶨CLDNA

<400> 1

acggtggctg caccatctgt cttcatcttc ccgccatctg atgagcagtt gaaatctgga        60
actgcctctg ttgtgtgcct gctgaataac ttctatccca gagaggccaa agtacagtgg       120
aaggtggata acgccctcca atcgggtaac tcccaggaga gtgtcacaga gcaggacagc       180
aaggacagca cctacagcct cagcagcacc ctgacgctga gcaaagcaga ctacgagaaa       240
cacaaagtct acgcctgcga agtcacccat cagggcctga gctcgcccgt cacaaagagc       300
ttcaacaggg gagagtgtta g                                                 321

<210> 14
<211> 106
<212> PRT
<213> 2A1㶨CL

<400> 2

TVAAPSVFIF PPSDEQLKSG TASVVCLLNN FYPREAKVQW KVDNALQSGN SQESVTEQDS        60
KDSTYSLSST LTLSKADYEK HKVYACEVTH QGLSSPVTKS FNRGEC                      106



<210> 15
<211> 336
<212> DNA
<213> 2A1-LC-Cys110ins㶨CLDNA

<400> 1

gaaatcaaac gtacgtgtgt ggctgcacca tctgtcttca tcttcccgcc atctgatgag        60
cagttgaaat ctggaactgc ctctgttgtg tgcctgctga ataacttcta tcccagagag       120
gccaaagtac agtggaaggt ggataacgcc ctccaatcgg gtaactccca ggagagtgtc       180
acagagcagg acagcaagga cagcacctac agcctcagca gcaccctgac gctgagcaaa       240
gcagactacg agaaacacaa agtctacgcc tgcgaagtca cccatcaggg cctgagctcg       300
cccgtcacaa agagcttcaa caggggagag tgttag                                 336

<210> 16
<211> 111
<212> PRT
<213> 2A1-LC-Cys110ins㶨CL

<400> 2

EIKRTCVAAP SVFIFPPSDE QLKSGTASVV CLLNNFYPRE AKVQWKVDNA LQSGNSQESV       60
TEQDSKDSTY SLSSTLTLSK ADYEKHKVYA CEVTHQGLSS PVTKSFNRGE C               111



<210> 17
<211> 336
<212> DNA
<213> 2A1-LC-Cys111ins㶨CLDNA

<400> 1

gaaatcaaac gtacggtgtg tgctgcacca tctgtcttca tcttcccgcc atctgatgag         60
cagttgaaat ctggaactgc ctctgttgtg tgcctgctga ataacttcta tcccagagag        120
gccaaagtac agtggaaggt ggataacgcc ctccaatcgg gtaactccca ggagagtgtc        180
acagagcagg acagcaagga cagcacctac agcctcagca gcaccctgac gctgagcaaa        240
gcagactacg agaaacacaa agtctacgcc tgcgaagtca cccatcaggg cctgagctcg        300
cccgtcacaa agagcttcaa caggggagag tgttag                                  336

<210> 18
<211> 111
<212> PRT
<213> 2A1-LC-Cys111ins㶨CL

<400> 2

EIKRTVCAAP SVFIFPPSDE QLKSGTASVV CLLNNFYPRE AKVQWKVDNA LQSGNSQESV       60
TEQDSKDSTY SLSSTLTLSK ADYEKHKVYA CEVTHQGLSS PVTKSFNRGE C               111


<210> 19
<211> 336
<212> DNA
<213> 2A1-LC-Cys142ins㶨CLDNA

<400> 1

gaaatcaaac gtacggtggc tgcaccatct gtcttcatct tcccgccatc tgatgagcag         60
ttgaaatctg gaactgcctc tgttgtgtgc ctgctgaata acttctatcc ctgtagagag        120
gccaaagtac agtggaaggt ggataacgcc ctccaatcgg gtaactccca ggagagtgtc        180
acagagcagg acagcaagga cagcacctac agcctcagca gcaccctgac gctgagcaaa        240
gcagactacg agaaacacaa agtctacgcc tgcgaagtca cccatcaggg cctgagctcg        300
cccgtcacaa agagcttcaa caggggagag tgttag                                  336

<210> 20
<211> 111
<212> PRT
<213> 2A1-LC-Cys142ins㶨CL

<400> 2

EIKRTVAAPS VFIFPPSDEQ LKSGTASVVC LLNNFYPCRE AKVQWKVDNA LQSGNSQESV       60
TEQDSKDSTY SLSSTLTLSK ADYEKHKVYA CEVTHQGLSS PVTKSFNRGE C               111



<210> 21
<211> 993
<212> DNA
<213> 2A1-HC-Cys254ins㶨CHDNA

<400> 1

gctagcacca agggcccatc ggtcttcccc ctggcaccct cctccaagag cacctctggg         60
ggcacagcgg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg        120
tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca        180
ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacccagacc        240
tacatctgca acgtgaatca caagcccagc aacaccaagg tggacaagag agttgagccc        300
aaatcttgtg acaaaactca cacatgccca ccgtgcccag cacctgaatt cctgggggga        360
ccgtcagtct tcctcttccc cccaaaaccc aaggacaccc tcatgatctc ccggacccct        420
tgtgaggtca catgcgtggt ggtggacgtg agccacgaag accctgaggt caagttcaac        480
tggtacgtgg acggcgtgga ggtgcataat gccaagacaa agccgcggga ggagcagtac        540
aacagcacgt accgtgtggt cagcgtcctc accgtcctgc accaggactg gctgaatggc        600
aaggagtaca agtgcaaggt ctccaacaaa gccctcccag cccccatcga gaaaaccatc        660
tccaaagcca aagggcagcc ccgagaacca caggtgtaca ccctgccccc atcccgggat        720
gagctgacca agaaccaggt cagcctgacc tgcctggtca aaggcttcta tcccagcgac        780
atcgccgtgg agtgggagag caatgggcag ccggagaaca actacaagac cacgcctccc        840
gtgctggact ccgacggctc cttcttcctc tatagcaagc tcaccgtgga caagagcagg        900
tggcagcagg ggaacgtctt ctcatgctcc gtgatgcatg aggctctgca caaccactac        960
acgcagaaga gcctctccct gtctccgggt taa                                     993

<210> 22
<211> 330
<212> PRT
<213> 2A1-HC-Cys254ins㶨CH

<400> 2

ASTKGPSVFP LAPSSKSTSG GTAALGCLVK DYFPEPVTVS WNSGALTSGV HTFPAVLQSS         60
GLYSLSSVVT VPSSSLGTQT YICNVNHKPS NTKVDKRVEP KSCDKTHTCP PCPAPEFLGG        120
PSVFLFPPKP KDTLMISRTP CEVTCVVVDV SHEDPEVKFN WYVDGVEVHN AKTKPREEQY        180
NSTYRVVSVL TVLHQDWLNG KEYKCKVSNK ALPAPIEKTI SKAKGQPREP QVYTLPPSRD        240
ELTKNQVSLT CLVKGFYPSD IAVEWESNGQ PENNYKTTPP VLDSDGSFFL YSKLTVDKSR        300
WQQGNVFSCS VMHEALHNHY TQKSLSLSPG                                         330



<210> 23
<211> 993
<212> DNA
<213> 2A1-HC-Cys255ins㶨CHDNA

<400> 1

gctagcacca agggcccatc ggtcttcccc ctggcaccct cctccaagag cacctctggg         60
ggcacagcgg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg        120
tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca        180
ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacccagacc        240
tacatctgca acgtgaatca caagcccagc aacaccaagg tggacaagag agttgagccc        300
aaatcttgtg acaaaactca cacatgccca ccgtgcccag cacctgaatt cctgggggga        360
ccgtcagtct tcctcttccc cccaaaaccc aaggacaccc tcatgatctc ccggacccct        420
gagtgtgtca catgcgtggt ggtggacgtg agccacgaag accctgaggt caagttcaac        480
tggtacgtgg acggcgtgga ggtgcataat gccaagacaa agccgcggga ggagcagtac        540
aacagcacgt accgtgtggt cagcgtcctc accgtcctgc accaggactg gctgaatggc        600
aaggagtaca agtgcaaggt ctccaacaaa gccctcccag cccccatcga gaaaaccatc        660
tccaaagcca aagggcagcc ccgagaacca caggtgtaca ccctgccccc atcccgggat        720
gagctgacca agaaccaggt cagcctgacc tgcctggtca aaggcttcta tcccagcgac        780
atcgccgtgg agtgggagag caatgggcag ccggagaaca actacaagac cacgcctccc        840
gtgctggact ccgacggctc cttcttcctc tatagcaagc tcaccgtgga caagagcagg        900
tggcagcagg ggaacgtctt ctcatgctcc gtgatgcatg aggctctgca caaccactac        960
acgcagaaga gcctctccct gtctccgggt taa                                     993

<210> 24
<211> 330
<212> PRT
<213> 2A1-HC-Cys255ins㶨CH

<400> 2

ASTKGPSVFP LAPSSKSTSG GTAALGCLVK DYFPEPVTVS WNSGALTSGV HTFPAVLQSS         60
GLYSLSSVVT VPSSSLGTQT YICNVNHKPS NTKVDKRVEP KSCDKTHTCP PCPAPEFLGG        120
PSVFLFPPKP KDTLMISRTP ECVTCVVVDV SHEDPEVKFN WYVDGVEVHN AKTKPREEQY        180
NSTYRVVSVL TVLHQDWLNG KEYKCKVSNK ALPAPIEKTI SKAKGQPREP QVYTLPPSRD        240
ELTKNQVSLT CLVKGFYPSD IAVEWESNGQ PENNYKTTPP VLDSDGSFFL YSKLTVDKSR        300
WQQGNVFSCS VMHEALHNHY TQKSLSLSPG                                         330


<210> 25
<211> 993
<212> DNA
<213> 2A1-HC-Cys258ins㶨CHDNA

<400> 1

gctagcacca agggcccatc ggtcttcccc ctggcaccct cctccaagag cacctctggg         60
ggcacagcgg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg        120
tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca        180
ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacccagacc        240
tacatctgca acgtgaatca caagcccagc aacaccaagg tggacaagag agttgagccc        300
aaatcttgtg acaaaactca cacatgccca ccgtgcccag cacctgaatt cctgggggga        360
ccgtcagtct tcctcttccc cccaaaaccc aaggacaccc tcatgatctc ccggacccct        420
gaggtcacat gctgtgtggt ggtggacgtg agccacgaag accctgaggt caagttcaac        480
tggtacgtgg acggcgtgga ggtgcataat gccaagacaa agccgcggga ggagcagtac        540
aacagcacgt accgtgtggt cagcgtcctc accgtcctgc accaggactg gctgaatggc        600
aaggagtaca agtgcaaggt ctccaacaaa gccctcccag cccccatcga gaaaaccatc        660
tccaaagcca aagggcagcc ccgagaacca caggtgtaca ccctgccccc atcccgggat        720
gagctgacca agaaccaggt cagcctgacc tgcctggtca aaggcttcta tcccagcgac        780
atcgccgtgg agtgggagag caatgggcag ccggagaaca actacaagac cacgcctccc        840
gtgctggact ccgacggctc cttcttcctc tatagcaagc tcaccgtgga caagagcagg        900
tggcagcagg ggaacgtctt ctcatgctcc gtgatgcatg aggctctgca caaccactac        960
acgcagaaga gcctctccct gtctccgggt taa                                     993

<210> 26
<211> 330
<212> PRT
<213> 2A1-HC-Cys258ins㶨CH

<400> 2

ASTKGPSVFP LAPSSKSTSG GTAALGCLVK DYFPEPVTVS WNSGALTSGV HTFPAVLQSS         60
GLYSLSSVVT VPSSSLGTQT YICNVNHKPS NTKVDKRVEP KSCDKTHTCP PCPAPEFLGG        120
PSVFLFPPKP KDTLMISRTP EVTCCVVVDV SHEDPEVKFN WYVDGVEVHN AKTKPREEQY        180
NSTYRVVSVL TVLHQDWLNG KEYKCKVSNK ALPAPIEKTI SKAKGQPREP QVYTLPPSRD        240
ELTKNQVSLT CLVKGFYPSD IAVEWESNGQ PENNYKTTPP VLDSDGSFFL YSKLTVDKSR        300
WQQGNVFSCS VMHEALHNHY TQKSLSLSPG                                         330


<210> 27
<211> 993
<212> DNA
<213> 2A1-HC-Cys259ins㶨CHDNA

<400> 1

gctagcacca agggcccatc ggtcttcccc ctggcaccct cctccaagag cacctctggg         60
ggcacagcgg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg        120
tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca        180
ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacccagacc        240
tacatctgca acgtgaatca caagcccagc aacaccaagg tggacaagag agttgagccc        300
aaatcttgtg acaaaactca cacatgccca ccgtgcccag cacctgaatt cctgggggga        360
ccgtcagtct tcctcttccc cccaaaaccc aaggacaccc tcatgatctc ccggacccct        420
gaggtcacat gcgtgtgtgt ggtggacgtg agccacgaag accctgaggt caagttcaac        480
tggtacgtgg acggcgtgga ggtgcataat gccaagacaa agccgcggga ggagcagtac        540
aacagcacgt accgtgtggt cagcgtcctc accgtcctgc accaggactg gctgaatggc        600
aaggagtaca agtgcaaggt ctccaacaaa gccctcccag cccccatcga gaaaaccatc        660
tccaaagcca aagggcagcc ccgagaacca caggtgtaca ccctgccccc atcccgggat        720
gagctgacca agaaccaggt cagcctgacc tgcctggtca aaggcttcta tcccagcgac        780
atcgccgtgg agtgggagag caatgggcag ccggagaaca actacaagac cacgcctccc        840
gtgctggact ccgacggctc cttcttcctc tatagcaagc tcaccgtgga caagagcagg        900
tggcagcagg ggaacgtctt ctcatgctcc gtgatgcatg aggctctgca caaccactac        960
acgcagaaga gcctctccct gtctccgggt taa                                     993

<210> 28
<211> 330
<212> PRT
<213> 2A1-HC-Cys259ins㶨CH

<400> 2

ASTKGPSVFP LAPSSKSTSG GTAALGCLVK DYFPEPVTVS WNSGALTSGV HTFPAVLQSS        60
GLYSLSSVVT VPSSSLGTQT YICNVNHKPS NTKVDKRVEP KSCDKTHTCP PCPAPEFLGG       120
PSVFLFPPKP KDTLMISRTP EVTCVCVVDV SHEDPEVKFN WYVDGVEVHN AKTKPREEQY       180
NSTYRVVSVL TVLHQDWLNG KEYKCKVSNK ALPAPIEKTI SKAKGQPREP QVYTLPPSRD       240
ELTKNQVSLT CLVKGFYPSD IAVEWESNGQ PENNYKTTPP VLDSDGSFFL YSKLTVDKSR       300
WQQGNVFSCS VMHEALHNHY TQKSLSLSPG                                        330


<210> 29
<211> 993
<212> DNA
<213> 2A1-HC-Cys354ins㶨CHDNA

<400> 1

gctagcacca agggcccatc ggtcttcccc ctggcaccct cctccaagag cacctctggg        60
ggcacagcgg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg       120
tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca       180
ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacccagacc       240
tacatctgca acgtgaatca caagcccagc aacaccaagg tggacaagag agttgagccc       300
aaatcttgtg acaaaactca cacatgccca ccgtgcccag cacctgaatt cctgggggga       360
ccgtcagtct tcctcttccc cccaaaaccc aaggacaccc tcatgatctc ccggacccct       420
gaggtcacat gcgtggtggt ggacgtgagc cacgaagacc ctgaggtcaa gttcaactgg       480
tacgtggacg gcgtggaggt gcataatgcc aagacaaagc cgcgggagga gcagtacaac       540
agcacgtacc gtgtggtcag cgtcctcacc gtcctgcacc aggactggct gaatggcaag       600
gagtacaagt gcaaggtctc caacaaagcc ctcccagccc ccatcgagaa aaccatctcc       660
aaagccaaag ggcagccccg agaaccacag gtgtacaccc tgcccccatc ccgggatgag       720
tgtctgacca agaaccaggt cagcctgacc tgcctggtca aaggcttcta tcccagcgac       780
atcgccgtgg agtgggagag caatgggcag ccggagaaca actacaagac cacgcctccc       840
gtgctggact ccgacggctc cttcttcctc tatagcaagc tcaccgtgga caagagcagg       900
tggcagcagg ggaacgtctt ctcatgctcc gtgatgcatg aggctctgca caaccactac       960
acgcagaaga gcctctccct gtctccgggt taa                                    993

<210> 30
<211> 330
<212> PRT
<213> 2A1-HC-Cys354ins㶨CH

<400> 2

ASTKGPSVFP LAPSSKSTSG GTAALGCLVK DYFPEPVTVS WNSGALTSGV HTFPAVLQSS        60
GLYSLSSVVT VPSSSLGTQT YICNVNHKPS NTKVDKRVEP KSCDKTHTCP PCPAPEFLGG       120
PSVFLFPPKP KDTLMISRTP EVTCVVVDVS HEDPEVKFNW YVDGVEVHNA KTKPREEQYN       180
STYRVVSVLT VLHQDWLNGK EYKCKVSNKA LPAPIEKTIS KAKGQPREPQ VYTLPPSRDE       240
CLTKNQVSLT CLVKGFYPSD IAVEWESNGQ PENNYKTTPP VLDSDGSFFL YSKLTVDKSR       300
WQQGNVFSCS VMHEALHNHY TQKSLSLSPG                                        330


<210> 31
<211> 993
<212> DNA
<213> 2A1-HC-Cys355ins㶨CHDNA

<400> 1

gctagcacca agggcccatc ggtcttcccc ctggcaccct cctccaagag cacctctggg        60
ggcacagcgg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg       120
tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca       180
ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacccagacc       240
tacatctgca acgtgaatca caagcccagc aacaccaagg tggacaagag agttgagccc       300
aaatcttgtg acaaaactca cacatgccca ccgtgcccag cacctgaatt cctgggggga       360
ccgtcagtct tcctcttccc cccaaaaccc aaggacaccc tcatgatctc ccggacccct       420
gaggtcacat gcgtggtggt ggacgtgagc cacgaagacc ctgaggtcaa gttcaactgg       480
tacgtggacg gcgtggaggt gcataatgcc aagacaaagc cgcgggagga gcagtacaac       540
agcacgtacc gtgtggtcag cgtcctcacc gtcctgcacc aggactggct gaatggcaag       600
gagtacaagt gcaaggtctc caacaaagcc ctcccagccc ccatcgagaa aaccatctcc       660
aaagccaaag ggcagccccg agaaccacag gtgtacaccc tgcccccatc ccgggatgag       720
ctgtgtacca agaaccaggt cagcctgacc tgcctggtca aaggcttcta tcccagcgac       780
atcgccgtgg agtgggagag caatgggcag ccggagaaca actacaagac cacgcctccc       840
gtgctggact ccgacggctc cttcttcctc tatagcaagc tcaccgtgga caagagcagg       900
tggcagcagg ggaacgtctt ctcatgctcc gtgatgcatg aggctctgca caaccactac       960
acgcagaaga gcctctccct gtctccgggt taa                                    993

<210> 32
<211> 330
<212> PRT
<213> 2A1-HC-Cys355ins㶨CH

<400> 2

ASTKGPSVFP LAPSSKSTSG GTAALGCLVK DYFPEPVTVS WNSGALTSGV HTFPAVLQSS        60
GLYSLSSVVT VPSSSLGTQT YICNVNHKPS NTKVDKRVEP KSCDKTHTCP PCPAPEFLGG       120
PSVFLFPPKP KDTLMISRTP EVTCVVVDVS HEDPEVKFNW YVDGVEVHNA KTKPREEQYN       180
STYRVVSVLT VLHQDWLNGK EYKCKVSNKA LPAPIEKTIS KAKGQPREPQ VYTLPPSRDE       240
LCTKNQVSLT CLVKGFYPSD IAVEWESNGQ PENNYKTTPP VLDSDGSFFL YSKLTVDKSR       300
WQQGNVFSCS VMHEALHNHY TQKSLSLSPG                                        330


<210> 33
<211> 993
<212> DNA
<213> 2A1-HC-Cys357ins㶨CHDNA

<400> 1

gctagcacca agggcccatc ggtcttcccc ctggcaccct cctccaagag cacctctggg        60
ggcacagcgg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg       120
tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca       180
ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacccagacc       240
tacatctgca acgtgaatca caagcccagc aacaccaagg tggacaagag agttgagccc       300
aaatcttgtg acaaaactca cacatgccca ccgtgcccag cacctgaatt cctgggggga       360
ccgtcagtct tcctcttccc cccaaaaccc aaggacaccc tcatgatctc ccggacccct       420
gaggtcacat gcgtggtggt ggacgtgagc cacgaagacc ctgaggtcaa gttcaactgg       480
tacgtggacg gcgtggaggt gcataatgcc aagacaaagc cgcgggagga gcagtacaac       540
agcacgtacc gtgtggtcag cgtcctcacc gtcctgcacc aggactggct gaatggcaag       600
gagtacaagt gcaaggtctc caacaaagcc ctcccagccc ccatcgagaa aaccatctcc       660
aaagccaaag ggcagccccg agaaccacag gtgtacaccc tgcccccatc ccgggatgag       720
ctgaccaagt gtaaccaggt cagcctgacc tgcctggtca aaggcttcta tcccagcgac       780
atcgccgtgg agtgggagag caatgggcag ccggagaaca actacaagac cacgcctccc       840
gtgctggact ccgacggctc cttcttcctc tatagcaagc tcaccgtgga caagagcagg       900
tggcagcagg ggaacgtctt ctcatgctcc gtgatgcatg aggctctgca caaccactac       960
acgcagaaga gcctctccct gtctccgggt taa                                    993

<210> 34
<211> 330
<212> PRT
<213> 2A1-HC-Cys357ins㶨CH

<400> 2

ASTKGPSVFP LAPSSKSTSG GTAALGCLVK DYFPEPVTVS WNSGALTSGV HTFPAVLQSS        60
GLYSLSSVVT VPSSSLGTQT YICNVNHKPS NTKVDKRVEP KSCDKTHTCP PCPAPEFLGG       120
PSVFLFPPKP KDTLMISRTP EVTCVVVDVS HEDPEVKFNW YVDGVEVHNA KTKPREEQYN       180
STYRVVSVLT VLHQDWLNGK EYKCKVSNKA LPAPIEKTIS KAKGQPREPQ VYTLPPSRDE       240
LTKCNQVSLT CLVKGFYPSD IAVEWESNGQ PENNYKTTPP VLDSDGSFFL YSKLTVDKSR       300
WQQGNVFSCS VMHEALHNHY TQKSLSLSPG                                        330

<210> 35
<211> 993
<212> DNA
<213> 2A1-HC-Cys378ins㶨CHDNA

<400> 1

gctagcacca agggcccatc ggtcttcccc ctggcaccct cctccaagag cacctctggg        60
ggcacagcgg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg       120
tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca       180
ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacccagacc       240
tacatctgca acgtgaatca caagcccagc aacaccaagg tggacaagag agttgagccc       300
aaatcttgtg acaaaactca cacatgccca ccgtgcccag cacctgaatt cctgggggga       360
ccgtcagtct tcctcttccc cccaaaaccc aaggacaccc tcatgatctc ccggacccct       420
gaggtcacat gcgtggtggt ggacgtgagc cacgaagacc ctgaggtcaa gttcaactgg       480
tacgtggacg gcgtggaggt gcataatgcc aagacaaagc cgcgggagga gcagtacaac       540
agcacgtacc gtgtggtcag cgtcctcacc gtcctgcacc aggactggct gaatggcaag       600
gagtacaagt gcaaggtctc caacaaagcc ctcccagccc ccatcgagaa aaccatctcc       660
aaagccaaag ggcagccccg agaaccacag gtgtacaccc tgcccccatc ccgggatgag       720
ctgaccaaga accaggtcag cctgacctgc ctggtcaaag gcttctatcc cagcgacatc       780
gccgtggagt ggtgtgagag caatgggcag ccggagaaca actacaagac cacgcctccc       840
gtgctggact ccgacggctc cttcttcctc tatagcaagc tcaccgtgga caagagcagg       900
tggcagcagg ggaacgtctt ctcatgctcc gtgatgcatg aggctctgca caaccactac       960
acgcagaaga gcctctccct gtctccgggt taa                                    993

<210> 36
<211> 330
<212> PRT
<213> 2A1-HC-Cys378ins㶨CH

<400> 2

ASTKGPSVFP LAPSSKSTSG GTAALGCLVK DYFPEPVTVS WNSGALTSGV HTFPAVLQSS        60
GLYSLSSVVT VPSSSLGTQT YICNVNHKPS NTKVDKRVEP KSCDKTHTCP PCPAPEFLGG       120
PSVFLFPPKP KDTLMISRTP EVTCVVVDVS HEDPEVKFNW YVDGVEVHNA KTKPREEQYN       180
STYRVVSVLT VLHQDWLNGK EYKCKVSNKA LPAPIEKTIS KAKGQPREPQ VYTLPPSRDE       240
LTKNQVSLTC LVKGFYPSDI AVEWCESNGQ PENNYKTTPP VLDSDGSFFL YSKLTVDKSR       300
WQQGNVFSCS VMHEALHNHY TQKSLSLSPG                                        330


<210> 37
<211> 993
<212> DNA
<213> 2A1-HC-Cys379ins㶨CHDNA

<400> 1

gctagcacca agggcccatc ggtcttcccc ctggcaccct cctccaagag cacctctggg        60
ggcacagcgg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg       120
tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca       180
ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacccagacc       240
tacatctgca acgtgaatca caagcccagc aacaccaagg tggacaagag agttgagccc       300
aaatcttgtg acaaaactca cacatgccca ccgtgcccag cacctgaatt cctgggggga       360
ccgtcagtct tcctcttccc cccaaaaccc aaggacaccc tcatgatctc ccggacccct       420
gaggtcacat gcgtggtggt ggacgtgagc cacgaagacc ctgaggtcaa gttcaactgg       480
tacgtggacg gcgtggaggt gcataatgcc aagacaaagc cgcgggagga gcagtacaac       540
agcacgtacc gtgtggtcag cgtcctcacc gtcctgcacc aggactggct gaatggcaag       600
gagtacaagt gcaaggtctc caacaaagcc ctcccagccc ccatcgagaa aaccatctcc       660
aaagccaaag ggcagccccg agaaccacag gtgtacaccc tgcccccatc ccgggatgag       720
ctgaccaaga accaggtcag cctgacctgc ctggtcaaag gcttctatcc cagcgacatc       780
gccgtggagt gggagtgtag caatgggcag ccggagaaca actacaagac cacgcctccc       840
gtgctggact ccgacggctc cttcttcctc tatagcaagc tcaccgtgga caagagcagg       900
tggcagcagg ggaacgtctt ctcatgctcc gtgatgcatg aggctctgca caaccactac       960
acgcagaaga gcctctccct gtctccgggt taa                                    993

<210> 38
<211> 330
<212> PRT
<213> 2A1-HC-Cys379ins㶨CH

<400> 2

ASTKGPSVFP LAPSSKSTSG GTAALGCLVK DYFPEPVTVS WNSGALTSGV HTFPAVLQSS        60
GLYSLSSVVT VPSSSLGTQT YICNVNHKPS NTKVDKRVEP KSCDKTHTCP PCPAPEFLGG       120
PSVFLFPPKP KDTLMISRTP EVTCVVVDVS HEDPEVKFNW YVDGVEVHNA KTKPREEQYN       180
STYRVVSVLT VLHQDWLNGK EYKCKVSNKA LPAPIEKTIS KAKGQPREPQ VYTLPPSRDE       240
LTKNQVSLTC LVKGFYPSDI AVEWECSNGQ PENNYKTTPP VLDSDGSFFL YSKLTVDKSR       300
WQQGNVFSCS VMHEALHNHY TQKSLSLSPG                                        330

<210> 39
<211> 993
<212> DNA
<213> 2A1-HC-Cys386ins㶨CHDNA

<400> 1

gctagcacca agggcccatc ggtcttcccc ctggcaccct cctccaagag cacctctggg        60
ggcacagcgg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg       120
tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca       180
ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacccagacc       240
tacatctgca acgtgaatca caagcccagc aacaccaagg tggacaagag agttgagccc       300
aaatcttgtg acaaaactca cacatgccca ccgtgcccag cacctgaatt cctgggggga       360
ccgtcagtct tcctcttccc cccaaaaccc aaggacaccc tcatgatctc ccggacccct       420
gaggtcacat gcgtggtggt ggacgtgagc cacgaagacc ctgaggtcaa gttcaactgg       480
tacgtggacg gcgtggaggt gcataatgcc aagacaaagc cgcgggagga gcagtacaac       540
agcacgtacc gtgtggtcag cgtcctcacc gtcctgcacc aggactggct gaatggcaag       600
gagtacaagt gcaaggtctc caacaaagcc ctcccagccc ccatcgagaa aaccatctcc       660
aaagccaaag ggcagccccg agaaccacag gtgtacaccc tgcccccatc ccgggatgag       720
ctgaccaaga accaggtcag cctgacctgc ctggtcaaag gcttctatcc cagcgacatc       780
gccgtggagt gggagagcaa tgggcagccg gagaactgta actacaagac cacgcctccc       840
gtgctggact ccgacggctc cttcttcctc tatagcaagc tcaccgtgga caagagcagg       900
tggcagcagg ggaacgtctt ctcatgctcc gtgatgcatg aggctctgca caaccactac       960
acgcagaaga gcctctccct gtctccgggt taa                                    993

<210> 40
<211> 330
<212> PRT
<213> 2A1-HC-Cys386ins㶨CH

<400> 2

ASTKGPSVFP LAPSSKSTSG GTAALGCLVK DYFPEPVTVS WNSGALTSGV HTFPAVLQSS        60
GLYSLSSVVT VPSSSLGTQT YICNVNHKPS NTKVDKRVEP KSCDKTHTCP PCPAPEFLGG       120
PSVFLFPPKP KDTLMISRTP EVTCVVVDVS HEDPEVKFNW YVDGVEVHNA KTKPREEQYN       180
STYRVVSVLT VLHQDWLNGK EYKCKVSNKA LPAPIEKTIS KAKGQPREPQ VYTLPPSRDE       240
LTKNQVSLTC LVKGFYPSDI AVEWESNGQP ENCNYKTTPP VLDSDGSFFL YSKLTVDKSR       300
WQQGNVFSCS VMHEALHNHY TQKSLSLSPG                                        330


<210> 41
<211> 993
<212> DNA
<213> 2A1-HC-Cys387ins㶨CHDNA

<400> 1

gctagcacca agggcccatc ggtcttcccc ctggcaccct cctccaagag cacctctggg        60
ggcacagcgg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg       120
tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca       180
ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacccagacc       240
tacatctgca acgtgaatca caagcccagc aacaccaagg tggacaagag agttgagccc       300
aaatcttgtg acaaaactca cacatgccca ccgtgcccag cacctgaatt cctgggggga       360
ccgtcagtct tcctcttccc cccaaaaccc aaggacaccc tcatgatctc ccggacccct       420
gaggtcacat gcgtggtggt ggacgtgagc cacgaagacc ctgaggtcaa gttcaactgg       480
tacgtggacg gcgtggaggt gcataatgcc aagacaaagc cgcgggagga gcagtacaac       540
agcacgtacc gtgtggtcag cgtcctcacc gtcctgcacc aggactggct gaatggcaag       600
gagtacaagt gcaaggtctc caacaaagcc ctcccagccc ccatcgagaa aaccatctcc       660
aaagccaaag ggcagccccg agaaccacag gtgtacaccc tgcccccatc ccgggatgag       720
ctgaccaaga accaggtcag cctgacctgc ctggtcaaag gcttctatcc cagcgacatc       780
gccgtggagt gggagagcaa tgggcagccg gagaacaact gttacaagac cacgcctccc       840
gtgctggact ccgacggctc cttcttcctc tatagcaagc tcaccgtgga caagagcagg       900
tggcagcagg ggaacgtctt ctcatgctcc gtgatgcatg aggctctgca caaccactac       960
acgcagaaga gcctctccct gtctccgggt taa                                    993


<210> 42
<211> 330
<212> PRT
<213> 2A1-HC-Cys387ins㶨CH

<400> 2

ASTKGPSVFP LAPSSKSTSG GTAALGCLVK DYFPEPVTVS WNSGALTSGV HTFPAVLQSS        60
GLYSLSSVVT VPSSSLGTQT YICNVNHKPS NTKVDKRVEP KSCDKTHTCP PCPAPEFLGG       120
PSVFLFPPKP KDTLMISRTP EVTCVVVDVS HEDPEVKFNW YVDGVEVHNA KTKPREEQYN       180
STYRVVSVLT VLHQDWLNGK EYKCKVSNKA LPAPIEKTIS KAKGQPREPQ VYTLPPSRDE       240
LTKNQVSLTC LVKGFYPSDI AVEWESNGQP ENNCYKTTPP VLDSDGSFFL YSKLTVDKSR       300
WQQGNVFSCS VMHEALHNHY TQKSLSLSPG                                        330


<210> 43
<211> 993
<212> DNA
<213> 2A1-HC-Cys410ins㶨CHDNA

<400> 1

gctagcacca agggcccatc ggtcttcccc ctggcaccct cctccaagag cacctctggg        60
ggcacagcgg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg       120
tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca       180
ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacccagacc       240
tacatctgca acgtgaatca caagcccagc aacaccaagg tggacaagag agttgagccc       300
aaatcttgtg acaaaactca cacatgccca ccgtgcccag cacctgaatt cctgggggga       360
ccgtcagtct tcctcttccc cccaaaaccc aaggacaccc tcatgatctc ccggacccct       420
gaggtcacat gcgtggtggt ggacgtgagc cacgaagacc ctgaggtcaa gttcaactgg       480
tacgtggacg gcgtggaggt gcataatgcc aagacaaagc cgcgggagga gcagtacaac       540
agcacgtacc gtgtggtcag cgtcctcacc gtcctgcacc aggactggct gaatggcaag       600
gagtacaagt gcaaggtctc caacaaagcc ctcccagccc ccatcgagaa aaccatctcc       660
aaagccaaag ggcagccccg agaaccacag gtgtacaccc tgcccccatc ccgggatgag       720
ctgaccaaga accaggtcag cctgacctgc ctggtcaaag gcttctatcc cagcgacatc       780
gccgtggagt gggagagcaa tgggcagccg gagaacaact acaagaccac gcctcccgtg       840
ctggactccg acggctcctt cttcctctat agcaagctca ccgtggactg taagagcagg       900
tggcagcagg ggaacgtctt ctcatgctcc gtgatgcatg aggctctgca caaccactac       960
acgcagaaga gcctctccct gtctccgggt taa                                    993

<210> 44
<211> 330
<212> PRT
<213> 2A1-HC-Cys410ins㶨CH

<400> 2

ASTKGPSVFP LAPSSKSTSG GTAALGCLVK DYFPEPVTVS WNSGALTSGV HTFPAVLQSS        60
GLYSLSSVVT VPSSSLGTQT YICNVNHKPS NTKVDKRVEP KSCDKTHTCP PCPAPEFLGG       120
PSVFLFPPKP KDTLMISRTP EVTCVVVDVS HEDPEVKFNW YVDGVEVHNA KTKPREEQYN       180
STYRVVSVLT VLHQDWLNGK EYKCKVSNKA LPAPIEKTIS KAKGQPREPQ VYTLPPSRDE       240
LTKNQVSLTC LVKGFYPSDI AVEWESNGQP ENNYKTTPPV LDSDGSFFLY SKLTVDCKSR       300
WQQGNVFSCS VMHEALHNHY TQKSLSLSPG                                        330

