                         SEQUENCE LISTING

<110>  ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF 
       ARIZONA
       Herman, Eliot
       Warner, Brad
       Schmidt, Monica
 
<120>  Methods, Systems, and Compositions for Legume-Based Production of
        Therapeutic Proteins and Therapeutic Medical Materials

<130>  UNIA 17.30 PCT

<150>  US 62/521,161
<151>  2017-06-16

<160>  34    

<170>  PatentIn version 3.5

<210>  1
<211>  180
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Modified EGF DNA sequence

<400>  1
tctctttctt cagccgaaaa ttccgatagt gagtgtccac tctcccatga tggctattgt       60

ttgcacgacg gagtttgcat gtatattgaa gctttggata agtacgcatg taactgcgtt      120

gtgggatata tcggtgaaag atgccaatac agggacctca aatggtggga gctgagataa      180


<210>  2
<211>  171
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Altered mod hEGF nucleaic acid sequence

<400>  2
tcagccgaaa cttccgatag tgagtgtcca ctctcccatg atggctattg tttgcacgac       60

ggagttcgca tgtatattga agctttggat aagtacgcat gtaactgcgt tgtgggatat      120

atcggtgaaa gatgccaata cagggacctc aaatggtggg agctgagata a               171


<210>  3
<211>  171
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Altered modhEGF nucleic acid sequence

<400>  3
tcagccgaaa actccgctag tgagtgtcca ctctcccatg atggctattg tttgcacgac       60

ggagttcgca tgtatattga agctttggat aagtacgcat ataactgcgt tgtgggatat      120

atcggtgaaa gatgccaata cagggacctc aaatggtggg agctgagata a               171


<210>  4
<211>  171
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Altered ModhEGF nucleic acid sequence

<400>  4
tcagccgaaa actccgctag tgagtgttca ctctcccatg atggcgattg tttgcacgac       60

ggagttcgca tgtatattga agctttggat aagtacgcat ataactgcgt tgtggaatat      120

atcggtgaaa gaggccaata cagggacctc aaacggtggg agctgagata a               171


<210>  5
<211>  171
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Altered modhEGF nucleic acid sequence

<400>  5
tcagccgaaa actccgctat tgagtgttca ctctcccctg atggcgattg tttgcacgac       60

ggagttcgca tgtatattga agctttgtat aagtacgcat ataactgcgt tgtggaatat      120

atcggtgaaa gaggccaata caggaacctc aaacggtggg agctgagata a               171


<210>  6
<211>  171
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Altered modhEGF nucleic acid sequence

<400>  6
tcagccgaaa actccgctat tgagtgttca ctctcccctg atggcgattg tttgcaagac       60

gtagttcgca tgtatagtga agctttgtat aagtacgcat ataactgcgt tgtggaatat      120

ctcggtgaaa gaggccaata caggaacctc aaacggtgga agctgagata a               171


<210>  7
<211>  171
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Altered modhEGF nucleic acid sequence

<400>  7
tcagccgaaa atcccgatag tgagtgtcca ctctgccatg ctggctattg ttcgcacgac       60

ggagtttgca tgtatattgt agctgtggat aagtacgcat gtaactgcgc tgtgggatat      120

atcggtgcaa gatgccaata cagcgacctc aaatggtggg acccgagata a               171


<210>  8
<211>  171
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Altered modhEGF nucleic acid sequence

<400>  8
tcagccgaaa atcccgatcg tgagtgtcca ctctgccatg ctggctattg ttcgcacgac       60

ggagtttgca tgtatattgt agctgtggat aagtacgcat gtaactgcgc tgtgggatat      120

atcggtgcaa gatgccaata cagcgacctc aaatggtggg acccgagata a               171


<210>  9
<211>  171
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Altered modhEGF nucleic acid sequence

<400>  9
tcagccgaaa atcccgatcg tgagtgtcca ctctgccatg ctggctattg ttcgcacgac       60

ggagtttgca tgtatattgt agctgtggat aagtacgcat gtaactgcgc tgtgggatat      120

atcggtgcaa gatgccaata cagcgacctc aaatggtggg acccgagata a               171


<210>  10
<211>  171
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Altered modhEGF nucleic acid sequence

<400>  10
tcagccgaaa atcccgatcg tgcgtgtcca ctctgccatg ctgtctattg ttcgcacgac       60

ggagtttgca tgtatattgt agctgtggat aagtacgcat gtaactgcgc tgtgggatat      120

atcggtgcaa gatgccaata cagcgacctc aaatggtggg acccgagata a               171


<210>  11
<211>  171
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Altered modhEGF nucleic acid sequence

<400>  11
tcagccgaaa atcccgatcg tgcgtgtcta ctctgccatg ctgtctattg ttcgcacgac       60

agagtttgca tgtatattgt agctgtggat aagtactcat gtaactgcgc tgtgggatgt      120

atcggtgcaa gatgccaata cagcgacctc aattggtggg agccgagata a               171


<210>  12
<211>  59
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified EGF protein sequence

<400>  12

Ser Leu Ser Ser Ala Glu Asn Ser Asp Ser Glu Cys Pro Leu Ser His 
1               5                   10                  15      


Asp Gly Tyr Cys Leu His Asp Gly Val Cys Met Tyr Ile Glu Ala Leu 
            20                  25                  30          


Asp Lys Tyr Ala Cys Asn Cys Val Val Gly Tyr Ile Gly Glu Arg Cys 
        35                  40                  45              


Gln Tyr Arg Asp Leu Lys Trp Trp Glu Leu Arg 
    50                  55                  


<210>  13
<211>  59
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Altered modhEGF protein sequence

<400>  13

Ser Leu Ser Ser Ala Glu Thr Ser Asp Ser Glu Cys Pro Leu Ser His 
1               5                   10                  15      


Asp Gly Tyr Cys Leu His Asp Gly Val Arg Met Tyr Ile Glu Ala Leu 
            20                  25                  30          


Asp Lys Tyr Ala Cys Asn Cys Val Val Gly Tyr Ile Gly Glu Arg Cys 
        35                  40                  45              


Gln Tyr Arg Asp Leu Lys Trp Trp Glu Leu Arg 
    50                  55                  


<210>  14
<211>  59
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Altered modhEGF protein sequence

<400>  14

Ser Leu Ser Ser Ala Glu Thr Ser Ala Ser Glu Cys Pro Leu Ser His 
1               5                   10                  15      


Asp Gly Tyr Cys Leu His Asp Gly Val Arg Met Tyr Ile Glu Ala Leu 
            20                  25                  30          


Asp Lys Tyr Ala Tyr Asn Cys Val Val Gly Tyr Ile Gly Glu Arg Cys 
        35                  40                  45              


Gln Tyr Arg Asp Leu Lys Trp Trp Glu Leu Arg 
    50                  55                  


<210>  15
<211>  59
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Altered modhEGF protein sequence

<400>  15

Ser Leu Ser Ser Ala Glu Thr Ser Ala Ser Glu Cys Ser Leu Ser His 
1               5                   10                  15      


Asp Gly Asp Cys Leu His Asp Gly Val Arg Met Tyr Ile Glu Ala Leu 
            20                  25                  30          


Asp Lys Tyr Ala Tyr Asn Cys Val Val Glu Tyr Ile Gly Glu Arg Gly 
        35                  40                  45              


Gln Tyr Arg Asp Leu Lys Arg Trp Glu Leu Arg 
    50                  55                  


<210>  16
<211>  59
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Altered modhEGF protein sequence

<400>  16

Ser Leu Ser Ser Ala Glu Thr Ser Ala Ile Glu Cys Ser Leu Ser Pro 
1               5                   10                  15      


Asp Gly Asp Cys Leu His Asp Gly Val Arg Met Tyr Ile Glu Ala Leu 
            20                  25                  30          


Tyr Lys Tyr Ala Tyr Asn Cys Val Val Glu Tyr Ile Gly Glu Arg Gly 
        35                  40                  45              


Gln Tyr Arg Asn Leu Lys Arg Trp Glu Leu Arg 
    50                  55                  


<210>  17
<211>  59
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Altered modhEGF protein sequence

<400>  17

Ser Leu Ser Ser Ala Glu Thr Ser Ala Ile Glu Cys Ser Leu Ser Pro 
1               5                   10                  15      


Asp Gly Asp Cys Leu Gln Asp Val Val Arg Met Tyr Ser Glu Ala Leu 
            20                  25                  30          


Tyr Lys Tyr Ala Tyr Asn Cys Val Val Glu Tyr Leu Gly Glu Arg Gly 
        35                  40                  45              


Gln Tyr Arg Asn Leu Lys Arg Trp Lys Leu Arg 
    50                  55                  


<210>  18
<211>  59
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Altered modhEGF protein sequence

<400>  18

Ser Leu Ser Ser Ala Glu Asn Ala Asp Ser Glu Cys Pro Leu Ser His 
1               5                   10                  15      


Asp Gly Tyr Cys Leu His Asp Gly Val Cys Met Tyr Ile Val Ala Leu 
            20                  25                  30          


Asp Lys Tyr Ala Cys Asn Cys Val Val Gly Tyr Ile Gly Glu Arg Cys 
        35                  40                  45              


Gln Tyr Arg Asp Leu Lys Trp Trp Glu Leu Arg 
    50                  55                  


<210>  19
<211>  59
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Altered modhEGF protein sequence

<400>  19

Ser Leu Ser Ser Ala Glu Asn Ala Asp Arg Glu Cys Pro Leu Ser His 
1               5                   10                  15      


Ala Gly Tyr Cys Leu His Asp Gly Val Cys Met Tyr Ile Val Ala Leu 
            20                  25                  30          


Asp Lys Tyr Ala Cys Asn Cys Val Val Gly Tyr Ile Gly Glu Arg Cys 
        35                  40                  45              


Gln Tyr Arg Asp Leu Lys Trp Trp Glu Leu Arg 
    50                  55                  


<210>  20
<211>  59
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Altered modhEGF protein sequence

<400>  20

Ser Leu Ser Ser Ala Glu Asn Ala Asp Arg Glu Cys Pro Leu Cys His 
1               5                   10                  15      


Ala Gly Tyr Cys Ser His Asp Gly Val Cys Met Tyr Ile Val Ala Leu 
            20                  25                  30          


Asp Lys Tyr Ala Cys Asn Cys Ala Val Gly Tyr Ile Gly Glu Arg Cys 
        35                  40                  45              


Gln Tyr Ser Asp Leu Lys Trp Trp Glu Pro Arg 
    50                  55                  


<210>  21
<211>  59
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Altered modhEGF protein sequence

<400>  21

Ser Leu Ser Ser Ala Glu Asn Ala Asp Arg Ala Cys Pro Leu Cys His 
1               5                   10                  15      


Ala Val Tyr Cys Ser His Asp Gly Val Cys Met Tyr Ile Val Ala Val 
            20                  25                  30          


Asp Lys Tyr Ala Cys Asn Cys Ala Val Gly Tyr Ile Gly Ala Arg Cys 
        35                  40                  45              


Gln Tyr Ser Asp Leu Lys Trp Trp Glu Pro Arg 
    50                  55                  


<210>  22
<211>  59
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Altered modhEGF protein sequence

<400>  22

Ser Leu Ser Ser Ala Glu Asn Ala Asp Arg Ala Cys Leu Leu Cys His 
1               5                   10                  15      


Ala Val Tyr Cys Ser His Asp Arg Val Cys Met Tyr Ile Val Ala Val 
            20                  25                  30          


Asp Lys Tyr Ser Cys Asn Cys Ala Val Gly Cys Ile Gly Ala Arg Cys 
        35                  40                  45              


Gln Tyr Ser Asp Leu Asn Trp Trp Glu Pro Arg 
    50                  55                  


<210>  23
<211>  165
<212>  DNA
<213>  Homo sapiens

<400>  23
gtaagaaata gtgactctga atgtcccctg tcccacgatg ggtactgcct ccatgatggt       60

gtgtgcatgt atattgaagc attggacaag tatgcatgca actgtgttgt tggctacatc      120

ggggagcgat gtcagtaccg agacctgaag tggtgggaac tgcgc                      165


<210>  24
<211>  39
<212>  PRT
<213>  Homo sapiens

<400>  24

Met Lys Thr Asn Leu Phe Leu Phe Leu Ile Phe Ser Leu Leu Leu Ser 
1               5                   10                  15      


Leu Ser Ser Ala Glu Phe Lys Thr Asn Leu Phe Leu Phe Leu Ile Phe 
            20                  25                  30          


Ser Leu Leu Leu Ser Leu Ser 
        35                  


<210>  25
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  25

Lys His Asp Glu Leu 
1               5   


<210>  26
<211>  162
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Modified hEGF coding region

<400>  26
aattccgata gtgagtgtcc actctcccat gatggctatt gtttgcacga cggagtttgc       60

atgtatattg aagctttgga taagtacgca tgtaactgcg ttgtgggata tatcggtgaa      120

agatgccaat acagggacct caaatggtgg gagctgagat aa                         162


<210>  27
<211>  162
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Altered modhEGF coding nucleic acid sequence

<400>  27
acttccgata gtgagtgtcc actctcccat gatggctatt gtttgcacga cggagttcgc       60

atgtatattg aagctttgga taagtacgca tgtaactgcg ttgtgggata tatcggtgaa      120

agatgccaat acagggacct caaatggtgg gagctgagat aa                         162


<210>  28
<211>  162
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Altered modhEGF coding nucleic acid sequence

<400>  28
aactccgcta gtgagtgtcc actctcccat gatggctatt gtttgcacga cggagttcgc       60

atgtatattg aagctttgga taagtacgca tataactgcg ttgtgggata tatcggtgaa      120

agatgccaat acagggacct caaatggtgg gagctgagat aa                         162


<210>  29
<211>  162
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Altered modhEGF coding nucleic acid sequence

<400>  29
aactccgcta gtgagtgttc actctcccat gatggcgatt gtttgcacga cggagttcgc       60

atgtatattg aagctttgga taagtacgca tataactgcg ttgtggaata tatcggtgaa      120

agaggccaat acagggacct caaacggtgg gagctgagat aa                         162


<210>  30
<211>  162
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Altered modhEGF cding nucleic acid sequence

<400>  30
aactccgcta ttgagtgttc actctcccct gatggcgatt gtttgcacga cggagttcgc       60

atgtatattg aagctttgta taagtacgca tataactgcg ttgtggaata tatcggtgaa      120

agaggccaat acaggaacct caaacggtgg gagctgagat aa                         162


<210>  31
<211>  162
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Altered modhEGF coding nucleic acid sequence

<400>  31
aactccgcta ttgagtgttc actctcccct gatggcgatt gtttgcaaga cgtagttcgc       60

atgtatagtg aagctttgta taagtacgca tataactgcg ttgtggaata tctcggtgaa      120

agaggccaat acaggaacct caaacggtgg aagctgagat aa                         162


<210>  32
<211>  18
<212>  DNA
<213>  Homo sapiens

<400>  32
tctctttctt cagccgaa                                                     18


<210>  33
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Altered nucleic acid sequence

<400>  33
tctttttctt cagccgaa                                                     18


<210>  34
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Altered nucleic acid sequence

<400>  34
tctttttctt aagccgaa                                                     18


