                         SEQUENCE LISTING

<110>  Crea, Roberto
       Yoon, Jun
       Hokanson, Craig
       Zacco, Emanuela
 
<120>  FIBRONECTIN BINDING DOMAIN CHIMERIC ANTIGEN RECEPTORS AND METHODS
        OF USE THEREOF

<130>  602712: PTI-009PC

<150>  62/521,095
<151>  2017-06-16

<160>  41    

<170>  PatentIn version 3.5

<210>  1
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(5)
<223>  Residues 1-5 are may be repeated more than one time.

<400>  1

Gly Ser Gly Gly Ser 
1               5   


<210>  2
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(4)
<223>  Residues 1-4 may be repeated more than one time.

<400>  2

Gly Gly Gly Ser 
1               


<210>  3
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence

<400>  3

Gly Gly Ser Gly 
1               


<210>  4
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence

<400>  4

Gly Gly Ser Gly Gly 
1               5   


<210>  5
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence

<400>  5

Gly Ser Gly Ser Gly 
1               5   


<210>  6
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence

<400>  6

Gly Ser Gly Gly Gly 
1               5   


<210>  7
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence

<400>  7

Gly Gly Gly Ser Gly 
1               5   


<210>  8
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence

<400>  8

Gly Ser Ser Ser Gly 
1               5   


<210>  9
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence

<400>  9

Asp Lys Thr His Thr 
1               5   


<210>  10
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence

<400>  10

Cys Pro Pro Cys 
1               


<210>  11
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence

<400>  11

Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg 
1               5                   10                  15  


<210>  12
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence

<400>  12

Glu Leu Lys Thr Pro Leu Gly Asp Thr Thr His Thr 
1               5                   10          


<210>  13
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence

<400>  13

Lys Ser Cys Asp Lys Thr His Thr Cys Pro 
1               5                   10  


<210>  14
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence

<400>  14

Lys Cys Cys Val Asp Cys Pro 
1               5           


<210>  15
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence

<400>  15

Lys Tyr Gly Pro Pro Cys Pro 
1               5           


<210>  16
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence

<400>  16

Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
1               5                   10                  15  


<210>  17
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence

<400>  17

Glu Arg Lys Cys Cys Val Glu Cys Pro Pro Cys Pro 
1               5                   10          


<210>  18
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence

<400>  18

Glu Leu Lys Thr Pro Leu Gly Asp Thr Thr His Thr Cys Pro Arg Cys 
1               5                   10                  15      


Pro 
    


<210>  19
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence

<400>  19

Ser Pro Asn Met Val Pro His Ala His His Ala Gln 
1               5                   10          


<210>  20
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence

<400>  20

Glu Pro Lys Ser Cys Asp Lys Thr Tyr Thr Cys Pro Pro Cys Pro 
1               5                   10                  15  


<210>  21
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence

<400>  21

Ala Ile Asp Ala Pro Ser Asn Leu Arg Phe Leu Ala Thr Thr Pro Asn 
1               5                   10                  15      


Ser Leu Leu Val 
            20  


<210>  22
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence

<400>  22

Ala Ile Asp Ala Pro Ser Asn Leu Arg Phe Leu Ala Thr Thr 
1               5                   10                  


<210>  23
<211>  179
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence

<400>  23

Asn Val Ser Pro Pro Arg Arg Ala Arg Val Thr Asp Ala Thr Glu Thr 
1               5                   10                  15      


Thr Ile Thr Ile Ser Trp Arg Thr Lys Thr Glu Thr Ile Thr Gly Phe 
            20                  25                  30          


Gln Val Asp Ala Val Pro Ala Asn Gly Gln Thr Pro Ile Gln Arg Thr 
        35                  40                  45              


Ile Lys Pro Asp Val Arg Ser Tyr Thr Ile Thr Gly Leu Gln Pro Gly 
    50                  55                  60                  


Thr Asp Tyr Lys Ile Tyr Leu Tyr Thr Leu Asn Asp Asn Ala Arg Ser 
65                  70                  75                  80  


Ser Pro Val Val Ile Asp Ala Ser Thr Ala Ile Asp Ala Pro Ser Asn 
                85                  90                  95      


Leu Arg Phe Leu Ala Thr Thr Pro Asn Ser Leu Leu Val Ser Trp Gln 
            100                 105                 110         


Pro Pro Arg Ala Arg Ile Thr Gly Tyr Ile Ile Lys Tyr Glu Lys Pro 
        115                 120                 125             


Gly Ser Pro Pro Arg Glu Val Val Pro Arg Pro Arg Pro Gly Val Thr 
    130                 135                 140                 


Glu Ala Thr Ile Thr Gly Leu Glu Pro Gly Thr Glu Tyr Thr Ile Tyr 
145                 150                 155                 160 


Val Ile Ala Leu Lys Asn Asn Gln Lys Ser Glu Pro Leu Ile Gly Arg 
                165                 170                 175     


Lys Lys Thr 
            


<210>  24
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence

<400>  24

Tyr Pro Tyr Asp Val Pro Asp Tyr Ala 
1               5                   


<210>  25
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence

<400>  25

Asp Tyr Lys Asp Asp Asp Asp Lys 
1               5               


<210>  26
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence

<400>  26

Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu 
1               5                   10  


<210>  27
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence

<400>  27

His His His His His 
1               5   


<210>  28
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence

<400>  28

His His His His His His 
1               5       


<210>  29
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence

<400>  29

Trp Ser His Pro Gln Phe Glu Lys 
1               5               


<210>  30
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence

<400>  30

Arg Tyr Ile Arg Ser 
1               5   


<210>  31
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence

<400>  31

Pro His His Thr 
1               


<210>  32
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence

<400>  32

Trp Glu Ala Ala Ala Arg Glu Ala Cys Cys Arg Glu Cys Cys Ala Arg 
1               5                   10                  15      


Ala 
    


<210>  33
<211>  91
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence

<400>  33

Asn Val Ser Pro Pro Arg Arg Ala Arg Val Thr Asp Ala Thr Glu Thr 
1               5                   10                  15      


Thr Ile Thr Ile Arg Trp Glu Gly Arg Gly Val Ile Gly Phe Gln Val 
            20                  25                  30          


Asp Ala Val Pro Ala Asn Gly Gln Thr Pro Ile Gln Arg Thr Ile Lys 
        35                  40                  45              


Pro Asp Val Arg Ser Tyr Thr Ile Thr Gly Leu Gln Pro Gly Thr Asp 
    50                  55                  60                  


Tyr Lys Ile Tyr Leu Tyr Thr Leu Pro Asn Ile Gly Thr Gly His Phe 
65                  70                  75                  80  


Ser Ser Ser Pro Val Val Ile Asp Ala Ser Thr 
                85                  90      


<210>  34
<211>  93
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence

<400>  34

Asn Val Ser Pro Pro Arg Arg Ala Arg Val Thr Asp Ala Thr Glu Thr 
1               5                   10                  15      


Thr Ile Thr Ile Ser Trp Glu Gly Ser Pro Ser Thr Phe Ile Gly Phe 
            20                  25                  30          


Gln Val Asp Ala Val Pro Ala Asn Gly Gln Thr Pro Ile Gln Arg Thr 
        35                  40                  45              


Ile Lys Pro Asp Val Arg Ser Tyr Thr Ile Thr Gly Leu Gln Pro Gly 
    50                  55                  60                  


Thr Asp Tyr Lys Ile Tyr Leu Tyr Thr Leu Pro Asp Phe Gly Arg Gly 
65                  70                  75                  80  


His Phe Thr Ser Ser Pro Val Val Ile Asp Ala Ser Thr 
                85                  90              


<210>  35
<211>  91
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence

<400>  35

Asn Val Ser Pro Pro Arg Arg Ala Arg Val Thr Asp Ala Thr Glu Thr 
1               5                   10                  15      


Thr Ile Thr Ile Arg Trp Glu Gly Arg Gly Val Ile Gly Phe Gln Val 
            20                  25                  30          


Asp Ala Val Pro Ala Asn Gly Gln Thr Pro Ile Gln Arg Thr Ile Lys 
        35                  40                  45              


Pro Asp Val Arg Ser Tyr Thr Ile Thr Gly Leu Gln Pro Gly Thr Asp 
    50                  55                  60                  


Tyr Lys Ile Tyr Leu Tyr Thr Leu Pro Asp Phe Gly Arg Gly His Phe 
65                  70                  75                  80  


Thr Ser Ser Pro Val Val Ile Asp Ala Ser Thr 
                85                  90      


<210>  36
<211>  93
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence

<400>  36

Asn Val Ser Pro Pro Arg Arg Ala Arg Val Thr Asp Ala Thr Glu Thr 
1               5                   10                  15      


Thr Ile Thr Ile Ser Trp Arg Val Ser Pro Ser Thr Val Val Gly Leu 
            20                  25                  30          


Gln Val Asp Ala Val Pro Ala Asn Gly Gln Thr Pro Ile Gln Arg Thr 
        35                  40                  45              


Ile Lys Pro Asp Val Arg Ser Tyr Thr Ile Thr Gly Leu Gln Pro Gly 
    50                  55                  60                  


Thr Asp Tyr Lys Ile Tyr Leu Tyr Thr Leu Asn Val Ile Gly Gly Ser 
65                  70                  75                  80  


Ala His Ala Ser Ser Pro Val Val Ile Asp Ala Ser Thr 
                85                  90              


<210>  37
<211>  373
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence

<400>  37

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Ser Gly Ala Arg Cys Asn Val Ser Pro Pro Arg Arg Ala Arg Val 
            20                  25                  30          


Thr Asp Ala Thr Glu Thr Thr Ile Thr Ile Arg Trp Glu Gly Arg Gly 
        35                  40                  45              


Val Ile Gly Phe Gln Val Asp Ala Val Pro Ala Asn Gly Gln Thr Pro 
    50                  55                  60                  


Ile Gln Arg Thr Ile Lys Pro Asp Val Arg Ser Tyr Thr Ile Thr Gly 
65                  70                  75                  80  


Leu Gln Pro Gly Thr Asp Tyr Lys Ile Tyr Leu Tyr Thr Leu Pro Asn 
                85                  90                  95      


Ile Gly Thr Gly His Phe Ser Ser Ser Pro Val Val Ile Asp Ala Ser 
            100                 105                 110         


Thr Gly Gly Gly Gly Ser Glu Leu Val Val Thr Gln Glu Pro Ser Leu 
        115                 120                 125             


Thr Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Arg Ser Ser Thr 
    130                 135                 140                 


Gly Ala Val Thr Thr Ser Asn Tyr Ala Asn Trp Val Gln Gln Lys Pro 
145                 150                 155                 160 


Gly Gln Ala Pro Arg Gly Leu Ile Gly Gly Thr Asn Lys Arg Ala Pro 
                165                 170                 175     


Gly Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala 
            180                 185                 190         


Leu Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys 
        195                 200                 205             


Ala Leu Trp Tyr Ser Asn Leu Trp Val Phe Gly Gly Gly Thr Lys Leu 
    210                 215                 220                 


Thr Val Leu Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
225                 230                 235                 240 


Gly Ser Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro 
                245                 250                 255     


Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn 
            260                 265                 270         


Thr Tyr Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu 
        275                 280                 285             


Trp Val Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr 
    290                 295                 300                 


Ala Asp Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys 
305                 310                 315                 320 


Asn Thr Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala 
                325                 330                 335     


Val Tyr Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Val Ser 
            340                 345                 350         


Trp Phe Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser His 
        355                 360                 365             


His His His His His 
    370             


<210>  38
<211>  373
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence

<400>  38

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Ser Gly Ala Arg Cys Asn Val Ser Pro Pro Arg Arg Ala Arg Val 
            20                  25                  30          


Thr Asp Ala Thr Glu Thr Thr Ile Thr Ile Arg Trp Glu Gly Arg Gly 
        35                  40                  45              


Val Ile Gly Phe Gln Val Asp Ala Val Pro Ala Asn Gly Gln Thr Pro 
    50                  55                  60                  


Ile Gln Arg Thr Ile Lys Pro Asp Val Arg Ser Tyr Thr Ile Thr Gly 
65                  70                  75                  80  


Leu Gln Pro Gly Thr Asp Tyr Lys Ile Tyr Leu Tyr Thr Leu Pro Asp 
                85                  90                  95      


Phe Gly Arg Gly His Phe Thr Ser Ser Pro Val Val Ile Asp Ala Ser 
            100                 105                 110         


Thr Gly Gly Gly Gly Ser Glu Leu Val Val Thr Gln Glu Pro Ser Leu 
        115                 120                 125             


Thr Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Arg Ser Ser Thr 
    130                 135                 140                 


Gly Ala Val Thr Thr Ser Asn Tyr Ala Asn Trp Val Gln Gln Lys Pro 
145                 150                 155                 160 


Gly Gln Ala Pro Arg Gly Leu Ile Gly Gly Thr Asn Lys Arg Ala Pro 
                165                 170                 175     


Gly Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala 
            180                 185                 190         


Leu Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys 
        195                 200                 205             


Ala Leu Trp Tyr Ser Asn Leu Trp Val Phe Gly Gly Gly Thr Lys Leu 
    210                 215                 220                 


Thr Val Leu Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
225                 230                 235                 240 


Gly Ser Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro 
                245                 250                 255     


Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn 
            260                 265                 270         


Thr Tyr Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu 
        275                 280                 285             


Trp Val Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr 
    290                 295                 300                 


Ala Asp Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys 
305                 310                 315                 320 


Asn Thr Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala 
                325                 330                 335     


Val Tyr Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Val Ser 
            340                 345                 350         


Trp Phe Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser His 
        355                 360                 365             


His His His His His 
    370             


<210>  39
<211>  375
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence

<400>  39

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Ser Gly Ala Arg Cys Asn Val Ser Pro Pro Arg Arg Ala Arg Val 
            20                  25                  30          


Thr Asp Ala Thr Glu Thr Thr Ile Thr Ile Ser Trp Arg Val Ser Pro 
        35                  40                  45              


Ser Thr Val Val Gly Leu Gln Val Asp Ala Val Pro Ala Asn Gly Gln 
    50                  55                  60                  


Thr Pro Ile Gln Arg Thr Ile Lys Pro Asp Val Arg Ser Tyr Thr Ile 
65                  70                  75                  80  


Thr Gly Leu Gln Pro Gly Thr Asp Tyr Lys Ile Tyr Leu Tyr Thr Leu 
                85                  90                  95      


Asn Val Ile Gly Gly Ser Ala His Ala Ser Ser Pro Val Val Ile Asp 
            100                 105                 110         


Ala Ser Thr Gly Gly Gly Gly Ser Glu Leu Val Val Thr Gln Glu Pro 
        115                 120                 125             


Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Arg Ser 
    130                 135                 140                 


Ser Thr Gly Ala Val Thr Thr Ser Asn Tyr Ala Asn Trp Val Gln Gln 
145                 150                 155                 160 


Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly Gly Thr Asn Lys Arg 
                165                 170                 175     


Ala Pro Gly Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly Lys 
            180                 185                 190         


Ala Ala Leu Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Glu Tyr 
        195                 200                 205             


Tyr Cys Ala Leu Trp Tyr Ser Asn Leu Trp Val Phe Gly Gly Gly Thr 
    210                 215                 220                 


Lys Leu Thr Val Leu Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
225                 230                 235                 240 


Gly Gly Gly Ser Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val 
                245                 250                 255     


Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr 
            260                 265                 270         


Phe Asn Thr Tyr Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly 
        275                 280                 285             


Leu Glu Trp Val Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr 
    290                 295                 300                 


Tyr Tyr Ala Asp Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp 
305                 310                 315                 320 


Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp 
                325                 330                 335     


Thr Ala Val Tyr Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr 
            340                 345                 350         


Val Ser Trp Phe Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
        355                 360                 365             


Ser His His His His His His 
    370                 375 


<210>  40
<211>  479
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence

<400>  40

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Ser Gly Ala Arg Cys Asn Val Ser Pro Pro Arg Arg Ala Arg Val 
            20                  25                  30          


Thr Asp Ala Thr Glu Thr Thr Ile Thr Ile Arg Trp Glu Gly Arg Gly 
        35                  40                  45              


Val Ile Gly Phe Gln Val Asp Ala Val Pro Ala Asn Gly Gln Thr Pro 
    50                  55                  60                  


Ile Gln Arg Thr Ile Lys Pro Asp Val Arg Ser Tyr Thr Ile Thr Gly 
65                  70                  75                  80  


Leu Gln Pro Gly Thr Asp Tyr Lys Ile Tyr Leu Tyr Thr Leu Pro Asn 
                85                  90                  95      


Ile Gly Thr Gly His Phe Ser Ser Ser Pro Val Val Ile Asp Ala Ser 
            100                 105                 110         


Thr Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Asn Val Ser Pro Pro Arg Arg Ala Arg Val Thr Asp Ala Thr Glu Thr 
    130                 135                 140                 


Thr Ile Thr Ile Arg Trp Glu Gly Arg Gly Val Ile Gly Phe Gln Val 
145                 150                 155                 160 


Asp Ala Val Pro Ala Asn Gly Gln Thr Pro Ile Gln Arg Thr Ile Lys 
                165                 170                 175     


Pro Asp Val Arg Ser Tyr Thr Ile Thr Gly Leu Gln Pro Gly Thr Asp 
            180                 185                 190         


Tyr Lys Ile Tyr Leu Tyr Thr Leu Pro Asp Phe Gly Arg Gly His Phe 
        195                 200                 205             


Thr Ser Ser Pro Val Val Ile Asp Ala Ser Thr Gly Gly Gly Gly Ser 
    210                 215                 220                 


Glu Leu Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly 
225                 230                 235                 240 


Thr Val Thr Leu Thr Cys Arg Ser Ser Thr Gly Ala Val Thr Thr Ser 
                245                 250                 255     


Asn Tyr Ala Asn Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly 
            260                 265                 270         


Leu Ile Gly Gly Thr Asn Lys Arg Ala Pro Gly Thr Pro Ala Arg Phe 
        275                 280                 285             


Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val 
    290                 295                 300                 


Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn 
305                 310                 315                 320 


Leu Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gly Gly 
                325                 330                 335     


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu 
            340                 345                 350         


Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Lys Leu 
        355                 360                 365             


Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Thr Tyr Ala Met Asn Trp 
    370                 375                 380                 


Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Arg 
385                 390                 395                 400 


Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser Val Lys Asp 
                405                 410                 415     


Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr Ala Tyr Leu Gln 
            420                 425                 430         


Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Val Arg 
        435                 440                 445             


His Gly Asn Phe Gly Asn Ser Tyr Val Ser Trp Phe Ala Tyr Trp Gly 
    450                 455                 460                 


Gln Gly Thr Leu Val Thr Val Ser Ser His His His His His His 
465                 470                 475                 


<210>  41
<211>  586
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence

<400>  41

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Ser Gly Ala Arg Cys Asn Val Ser Pro Pro Arg Arg Ala Arg Val 
            20                  25                  30          


Thr Asp Ala Thr Glu Thr Thr Ile Thr Ile Arg Trp Glu Gly Arg Gly 
        35                  40                  45              


Val Ile Gly Phe Gln Val Asp Ala Val Pro Ala Asn Gly Gln Thr Pro 
    50                  55                  60                  


Ile Gln Arg Thr Ile Lys Pro Asp Val Arg Ser Tyr Thr Ile Thr Gly 
65                  70                  75                  80  


Leu Gln Pro Gly Thr Asp Tyr Lys Ile Tyr Leu Tyr Thr Leu Pro Asn 
                85                  90                  95      


Ile Gly Thr Gly His Phe Ser Ser Ser Pro Val Val Ile Asp Ala Ser 
            100                 105                 110         


Thr Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Asn Val Ser Pro Pro Arg Arg Ala Arg Val Thr Asp Ala Thr Glu Thr 
    130                 135                 140                 


Thr Ile Thr Ile Arg Trp Glu Gly Arg Gly Val Ile Gly Phe Gln Val 
145                 150                 155                 160 


Asp Ala Val Pro Ala Asn Gly Gln Thr Pro Ile Gln Arg Thr Ile Lys 
                165                 170                 175     


Pro Asp Val Arg Ser Tyr Thr Ile Thr Gly Leu Gln Pro Gly Thr Asp 
            180                 185                 190         


Tyr Lys Ile Tyr Leu Tyr Thr Leu Pro Asp Phe Gly Arg Gly His Phe 
        195                 200                 205             


Thr Ser Ser Pro Val Val Ile Asp Ala Ser Thr Gly Gly Gly Gly Ser 
    210                 215                 220                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Asn Val Ser Pro Pro Arg Arg 
225                 230                 235                 240 


Ala Arg Val Thr Asp Ala Thr Glu Thr Thr Ile Thr Ile Ser Trp Arg 
                245                 250                 255     


Val Ser Pro Ser Thr Val Val Gly Leu Gln Val Asp Ala Val Pro Ala 
            260                 265                 270         


Asn Gly Gln Thr Pro Ile Gln Arg Thr Ile Lys Pro Asp Val Arg Ser 
        275                 280                 285             


Tyr Thr Ile Thr Gly Leu Gln Pro Gly Thr Asp Tyr Lys Ile Tyr Leu 
    290                 295                 300                 


Tyr Thr Leu Asn Val Ile Gly Gly Ser Ala His Ala Ser Ser Pro Val 
305                 310                 315                 320 


Val Ile Asp Ala Ser Thr Gly Gly Gly Gly Ser Glu Leu Val Val Thr 
                325                 330                 335     


Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu Thr 
            340                 345                 350         


Cys Arg Ser Ser Thr Gly Ala Val Thr Thr Ser Asn Tyr Ala Asn Trp 
        355                 360                 365             


Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly Gly Thr 
    370                 375                 380                 


Asn Lys Arg Ala Pro Gly Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu 
385                 390                 395                 400 


Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val Gln Pro Glu Asp Glu 
                405                 410                 415     


Ala Glu Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn Leu Trp Val Phe Gly 
            420                 425                 430         


Gly Gly Thr Lys Leu Thr Val Leu Gly Gly Gly Gly Ser Gly Gly Gly 
        435                 440                 445             


Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Leu Glu Ser Gly Gly 
    450                 455                 460                 


Gly Leu Val Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser 
465                 470                 475                 480 


Gly Phe Thr Phe Asn Thr Tyr Ala Met Asn Trp Val Arg Gln Ala Pro 
                485                 490                 495     


Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Arg Ser Lys Tyr Asn Asn 
            500                 505                 510         


Tyr Ala Thr Tyr Tyr Ala Asp Ser Val Lys Asp Arg Phe Thr Ile Ser 
        515                 520                 525             


Arg Asp Asp Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Asn Leu Lys 
    530                 535                 540                 


Thr Glu Asp Thr Ala Val Tyr Tyr Cys Val Arg His Gly Asn Phe Gly 
545                 550                 555                 560 


Asn Ser Tyr Val Ser Trp Phe Ala Tyr Trp Gly Gln Gly Thr Leu Val 
                565                 570                 575     


Thr Val Ser Ser His His His His His His 
            580                 585     


