                         SEQUENCE LISTING

<110>  The University of Chicago
 
<120>  Methods and Compositions for Treating Cancer

<130>  ARCD.P0633WO

<150>  62/520,325
<151>  2017-06-15

<150>  62/610,711
<151>  2017-12-27

<160>  8     

<170>  PatentIn version 3.5

<210>  1
<211>  160
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Val Pro Lys Leu Phe Thr Ser Gln Ile Cys Leu Leu Leu Leu Leu 
1               5                   10                  15      


Gly Leu Met Gly Val Glu Gly Ser Leu His Ala Arg Pro Pro Gln Phe 
            20                  25                  30          


Thr Arg Ala Gln Trp Phe Ala Ile Gln His Ile Ser Leu Asn Pro Pro 
        35                  40                  45              


Arg Cys Thr Ile Ala Met Arg Ala Ile Asn Asn Tyr Arg Trp Arg Cys 
    50                  55                  60                  


Lys Asn Gln Asn Thr Phe Leu Arg Thr Thr Phe Ala Asn Val Val Asn 
65                  70                  75                  80  


Val Cys Gly Asn Gln Ser Ile Arg Cys Pro His Asn Arg Thr Leu Asn 
                85                  90                  95      


Asn Cys His Arg Ser Arg Phe Arg Val Pro Leu Leu His Cys Asp Leu 
            100                 105                 110         


Ile Asn Pro Gly Ala Gln Asn Ile Ser Asn Cys Thr Tyr Ala Asp Arg 
        115                 120                 125             


Pro Gly Arg Arg Phe Tyr Val Val Ala Cys Asp Asn Arg Asp Pro Arg 
    130                 135                 140                 


Asp Ser Pro Arg Tyr Pro Val Val Pro Val His Leu Asp Thr Thr Ile 
145                 150                 155                 160 


<210>  2
<211>  267
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Thr Leu Gly Arg Arg Leu Ala Cys Leu Phe Leu Ala Cys Val Leu 
1               5                   10                  15      


Pro Ala Leu Leu Leu Gly Gly Thr Ala Leu Ala Ser Glu Ile Val Gly 
            20                  25                  30          


Gly Arg Arg Ala Arg Pro His Ala Trp Pro Phe Met Val Ser Leu Gln 
        35                  40                  45              


Leu Arg Gly Gly His Phe Cys Gly Ala Thr Leu Ile Ala Pro Asn Phe 
    50                  55                  60                  


Val Met Ser Ala Ala His Cys Val Ala Asn Val Asn Val Arg Ala Val 
65                  70                  75                  80  


Arg Val Val Leu Gly Ala His Asn Leu Ser Arg Arg Glu Pro Thr Arg 
                85                  90                  95      


Gln Val Phe Ala Val Gln Arg Ile Phe Glu Asn Gly Tyr Asp Pro Val 
            100                 105                 110         


Asn Leu Leu Asn Asp Ile Val Ile Leu Gln Leu Asn Gly Ser Ala Thr 
        115                 120                 125             


Ile Asn Ala Asn Val Gln Val Ala Gln Leu Pro Ala Gln Gly Arg Arg 
    130                 135                 140                 


Leu Gly Asn Gly Val Gln Cys Leu Ala Met Gly Trp Gly Leu Leu Gly 
145                 150                 155                 160 


Arg Asn Arg Gly Ile Ala Ser Val Leu Gln Glu Leu Asn Val Thr Val 
                165                 170                 175     


Val Thr Ser Leu Cys Arg Arg Ser Asn Val Cys Thr Leu Val Arg Gly 
            180                 185                 190         


Arg Gln Ala Gly Val Cys Phe Gly Asp Ser Gly Ser Pro Leu Val Cys 
        195                 200                 205             


Asn Gly Leu Ile His Gly Ile Ala Ser Phe Val Arg Gly Gly Cys Ala 
    210                 215                 220                 


Ser Gly Leu Tyr Pro Asp Ala Phe Ala Pro Val Ala Gln Phe Val Asn 
225                 230                 235                 240 


Trp Ile Asp Ser Ile Ile Gln Arg Ser Glu Asp Asn Pro Cys Pro His 
                245                 250                 255     


Pro Arg Asp Pro Asp Pro Ala Ser Arg Thr His 
            260                 265         


<210>  3
<211>  255
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Gln Pro Leu Leu Leu Leu Leu Ala Phe Leu Leu Pro Thr Gly Ala 
1               5                   10                  15      


Glu Ala Gly Glu Ile Ile Gly Gly Arg Glu Ser Arg Pro His Ser Arg 
            20                  25                  30          


Pro Tyr Met Ala Tyr Leu Gln Ile Gln Ser Pro Ala Gly Gln Ser Arg 
        35                  40                  45              


Cys Gly Gly Phe Leu Val Arg Glu Asp Phe Val Leu Thr Ala Ala His 
    50                  55                  60                  


Cys Trp Gly Ser Asn Ile Asn Val Thr Leu Gly Ala His Asn Ile Gln 
65                  70                  75                  80  


Arg Arg Glu Asn Thr Gln Gln His Ile Thr Ala Arg Arg Ala Ile Arg 
                85                  90                  95      


His Pro Gln Tyr Asn Gln Arg Thr Ile Gln Asn Asp Ile Met Leu Leu 
            100                 105                 110         


Gln Leu Ser Arg Arg Val Arg Arg Asn Arg Asn Val Asn Pro Val Ala 
        115                 120                 125             


Leu Pro Arg Ala Gln Glu Gly Leu Arg Pro Gly Thr Leu Cys Thr Val 
    130                 135                 140                 


Ala Gly Trp Gly Arg Val Ser Met Arg Arg Gly Thr Asp Thr Leu Arg 
145                 150                 155                 160 


Glu Val Gln Leu Arg Val Gln Arg Asp Arg Gln Cys Leu Arg Ile Phe 
                165                 170                 175     


Gly Ser Tyr Asp Pro Arg Arg Gln Ile Cys Val Gly Asp Arg Arg Glu 
            180                 185                 190         


Arg Lys Ala Ala Phe Lys Gly Asp Ser Gly Gly Pro Leu Leu Cys Asn 
        195                 200                 205             


Asn Val Ala His Gly Ile Val Ser Tyr Gly Lys Ser Ser Gly Val Pro 
    210                 215                 220                 


Pro Glu Val Phe Thr Arg Val Ser Ser Phe Leu Pro Trp Ile Arg Thr 
225                 230                 235                 240 


Thr Met Arg Ser Phe Lys Leu Leu Asp Gln Met Glu Thr Pro Leu 
                245                 250                 255 


<210>  4
<211>  256
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Ala His Arg Pro Pro Ser Pro Ala Leu Ala Ser Val Leu Leu Ala 
1               5                   10                  15      


Leu Leu Leu Ser Gly Ala Ala Arg Ala Ala Glu Ile Val Gly Gly His 
            20                  25                  30          


Glu Ala Gln Pro His Ser Arg Pro Tyr Met Ala Ser Leu Gln Met Arg 
        35                  40                  45              


Gly Asn Pro Gly Ser His Phe Cys Gly Gly Thr Leu Ile His Pro Ser 
    50                  55                  60                  


Phe Val Leu Thr Ala Ala His Cys Leu Arg Asp Ile Pro Gln Arg Leu 
65                  70                  75                  80  


Val Asn Val Val Leu Gly Ala His Asn Val Arg Thr Gln Glu Pro Thr 
                85                  90                  95      


Gln Gln His Phe Ser Val Ala Gln Val Phe Leu Asn Asn Tyr Asp Ala 
            100                 105                 110         


Glu Asn Lys Leu Asn Asp Val Leu Leu Ile Gln Leu Ser Ser Pro Ala 
        115                 120                 125             


Asn Leu Ser Ala Ser Val Ala Thr Val Gln Leu Pro Gln Gln Asp Gln 
    130                 135                 140                 


Pro Val Pro His Gly Thr Gln Cys Leu Ala Met Gly Trp Gly Arg Val 
145                 150                 155                 160 


Gly Ala His Asp Pro Pro Ala Gln Val Leu Gln Glu Leu Asn Val Thr 
                165                 170                 175     


Val Val Thr Phe Phe Cys Arg Pro His Asn Ile Cys Thr Phe Val Pro 
            180                 185                 190         


Arg Arg Lys Ala Gly Ile Cys Phe Gly Asp Ser Gly Gly Pro Leu Ile 
        195                 200                 205             


Cys Asp Gly Ile Ile Gln Gly Ile Asp Ser Phe Val Ile Trp Gly Cys 
    210                 215                 220                 


Ala Thr Arg Leu Phe Pro Asp Phe Phe Thr Arg Val Ala Leu Tyr Val 
225                 230                 235                 240 


Asp Trp Ile Arg Ser Thr Leu Arg Arg Val Glu Ala Lys Gly Arg Pro 
                245                 250                 255     


<210>  5
<211>  265
<212>  PRT
<213>  Mus musculus

<400>  5

Met Ala Leu Gly Arg Leu Ser Ser Arg Thr Leu Ala Ala Met Leu Leu 
1               5                   10                  15      


Ala Leu Phe Leu Gly Gly Pro Ala Leu Ala Ser Glu Ile Val Gly Gly 
            20                  25                  30          


Arg Pro Ala Arg Pro His Ala Trp Pro Phe Met Ala Ser Leu Gln Arg 
        35                  40                  45              


Arg Gly Gly His Phe Cys Gly Ala Thr Leu Ile Ala Arg Asn Phe Val 
    50                  55                  60                  


Met Ser Ala Ala His Cys Val Asn Gly Leu Asn Phe Arg Ser Val Gln 
65                  70                  75                  80  


Val Val Leu Gly Ala His Asp Leu Arg Arg Gln Glu Arg Thr Arg Gln 
                85                  90                  95      


Thr Phe Ser Val Gln Arg Ile Phe Glu Asn Gly Phe Asp Pro Ser Gln 
            100                 105                 110         


Leu Leu Asn Asp Ile Val Ile Ile Gln Leu Asn Gly Ser Ala Thr Ile 
        115                 120                 125             


Asn Ala Asn Val Gln Val Ala Gln Leu Pro Ala Gln Gly Gln Gly Val 
    130                 135                 140                 


Gly Asp Arg Thr Pro Cys Leu Ala Met Gly Trp Gly Arg Leu Gly Thr 
145                 150                 155                 160 


Asn Arg Pro Ser Pro Ser Val Leu Gln Glu Leu Asn Val Thr Val Val 
                165                 170                 175     


Thr Asn Met Cys Arg Arg Arg Val Asn Val Cys Thr Leu Val Pro Arg 
            180                 185                 190         


Arg Gln Ala Gly Ile Cys Phe Gly Asp Ser Gly Gly Pro Leu Val Cys 
        195                 200                 205             


Asn Asn Leu Val Gln Gly Ile Asp Ser Phe Ile Arg Gly Gly Cys Gly 
    210                 215                 220                 


Ser Gly Leu Tyr Pro Asp Ala Phe Ala Pro Val Ala Glu Phe Ala Asp 
225                 230                 235                 240 


Trp Ile Asn Ser Ile Ile Arg Ser His Asn Asp His Leu Leu Thr His 
                245                 250                 255     


Pro Lys Asp Arg Glu Gly Arg Thr Asn 
            260                 265 


<210>  6
<211>  266
<212>  PRT
<213>  Sus scrofa

<400>  6

Met Leu Arg Leu Leu Val Val Ala Ser Leu Val Leu Tyr Gly His Ser 
1               5                   10                  15      


Thr Gln Asp Phe Pro Glu Thr Asn Ala Arg Val Val Gly Gly Thr Glu 
            20                  25                  30          


Ala Gln Arg Asn Ser Trp Pro Ser Gln Ile Ser Leu Gln Tyr Arg Ser 
        35                  40                  45              


Gly Ser Ser Trp Ala His Thr Cys Gly Gly Thr Leu Ile Arg Gln Asn 
    50                  55                  60                  


Trp Val Met Thr Ala Ala His Cys Val Asp Arg Glu Leu Thr Phe Arg 
65                  70                  75                  80  


Val Val Val Gly Glu His Asn Leu Asn Gln Asn Asp Gly Thr Glu Gln 
                85                  90                  95      


Tyr Val Gly Val Gln Lys Ile Val Val His Pro Tyr Trp Asn Thr Asp 
            100                 105                 110         


Asp Val Ala Ala Gly Tyr Asp Ile Ala Leu Leu Arg Leu Ala Gln Ser 
        115                 120                 125             


Val Thr Leu Asn Ser Tyr Val Gln Leu Gly Val Leu Pro Arg Ala Gly 
    130                 135                 140                 


Thr Ile Leu Ala Asn Asn Ser Pro Cys Tyr Ile Thr Gly Trp Gly Leu 
145                 150                 155                 160 


Thr Arg Thr Asn Gly Gln Leu Ala Gln Thr Leu Gln Gln Ala Tyr Leu 
                165                 170                 175     


Pro Thr Val Asp Tyr Ala Ile Cys Ser Ser Ser Ser Tyr Trp Gly Ser 
            180                 185                 190         


Thr Val Lys Asn Ser Met Val Cys Ala Gly Gly Asp Gly Val Arg Ser 
        195                 200                 205             


Gly Cys Gln Gly Asp Ser Gly Gly Pro Leu His Cys Leu Val Asn Gly 
    210                 215                 220                 


Gln Tyr Ala Val His Gly Val Thr Ser Phe Val Ser Arg Leu Gly Cys 
225                 230                 235                 240 


Asn Val Thr Arg Lys Pro Thr Val Phe Thr Arg Val Ser Ala Tyr Ile 
                245                 250                 255     


Ser Trp Ile Asn Asn Val Ile Ala Ser Asn 
            260                 265     


<210>  7
<211>  266
<212>  PRT
<213>  Mus musculus

<400>  7

Met Leu Arg Phe Leu Val Phe Ala Ser Leu Val Leu Cys Gly His Ser 
1               5                   10                  15      


Thr Glu Asp Val Pro Glu Thr Asp Ala Arg Val Val Gly Gly Ala Glu 
            20                  25                  30          


Ala Arg Arg Asn Ser Trp Pro Ser Gln Ile Ser Leu Gln Tyr Gln Tyr 
        35                  40                  45              


Gly Gly Ser Trp His His Thr Cys Gly Gly Thr Leu Ile Arg Ser Asn 
    50                  55                  60                  


Trp Val Met Thr Ala Ala His Cys Val Asp Ser Pro Met Thr Tyr Arg 
65                  70                  75                  80  


Val Val Val Gly Glu His Asn Leu Ser Gln Asn Asp Gly Thr Glu Gln 
                85                  90                  95      


Tyr Val Asn Val Gln Lys Ile Val Ser His Pro Tyr Trp Asn Lys Asn 
            100                 105                 110         


Asn Val Val Ala Gly Tyr Asp Ile Ala Leu Leu Arg Leu Ala Lys Ser 
        115                 120                 125             


Val Thr Leu Asn Asn Tyr Val Gln Leu Gly Val Leu Pro Arg Glu Gly 
    130                 135                 140                 


Thr Ile Leu Ala Asn Asn Ser Pro Cys Tyr Ile Thr Gly Trp Gly Arg 
145                 150                 155                 160 


Thr Arg Thr Asn Gly Glu Leu Ala Gln Thr Leu Gln Gln Ala Tyr Leu 
                165                 170                 175     


Pro Ser Val Ser Tyr Ser Ile Cys Ser Ser Ser Ser Tyr Trp Gly Ser 
            180                 185                 190         


Ser Val Lys Asn Thr Met Val Cys Ala Gly Gly Asp Gly Val Arg Ser 
        195                 200                 205             


Gly Cys Gln Gly Asp Ser Gly Gly Pro Leu His Cys Met Val Asn Gly 
    210                 215                 220                 


Gln Tyr Ala Val His Gly Val Thr Ser Phe Val Ser Ser Met Gly Cys 
225                 230                 235                 240 


Asn Val Ala Arg Lys Pro Thr Val Phe Thr Arg Val Ser Ala Tyr Ile 
                245                 250                 255     


Ser Trp Met Asn Asn Val Ile Ala Ser Asn 
            260                 265     


<210>  8
<211>  269
<212>  PRT
<213>  Rattus norvegicus

<400>  8

Met Leu Arg Phe Leu Val Phe Ala Ser Leu Val Leu Tyr Gly His Ser 
1               5                   10                  15      


Thr Gln Asp Phe Pro Glu Thr Asn Ala Arg Val Val Gly Gly Ala Glu 
            20                  25                  30          


Ala Arg Arg Asn Ser Trp Pro Ser Gln Ile Ser Leu Gln Tyr Leu Ser 
        35                  40                  45              


Gly Gly Ser Trp Tyr His Thr Cys Gly Gly Thr Leu Ile Arg Arg Asn 
    50                  55                  60                  


Trp Val Met Thr Ala Ala His Cys Val Ser Ser Gln Met Thr Phe Arg 
65                  70                  75                  80  


Val Val Val Gly Asp His Asn Leu Ser Gln Asn Asp Gly Thr Glu Gln 
                85                  90                  95      


Tyr Val Ser Val Gln Lys Ile Val Val His Pro Asn Trp Asn Ser Asn 
            100                 105                 110         


Asn Val Ala Ala Gly Tyr Asp Ile Ala Leu Leu Arg Leu Ala Gln Ser 
        115                 120                 125             


Val Thr Leu Asn Asn Tyr Val Gln Leu Ala Val Leu Pro Gln Glu Gly 
    130                 135                 140                 


Thr Ile Leu Ala Asn Asn Asn Pro Cys Tyr Ile Thr Gly Trp Gly Arg 
145                 150                 155                 160 


Thr Arg Thr Asn Gly Gln Leu Ser Gln Thr Leu Gln Gln Ala Tyr Leu 
                165                 170                 175     


Pro Ser Val Asp Tyr Ser Ile Cys Ser Ser Ser Ser Tyr Trp Gly Ser 
            180                 185                 190         


Thr Val Lys Thr Thr Met Val Cys Ala Gly Gly Asp Gly Val Arg Ser 
        195                 200                 205             


Gly Cys Gln Gly Asp Ser Gly Gly Pro Leu His Cys Leu Val Asn Gly 
    210                 215                 220                 


Gln Tyr Ser Val His Gly Val Thr Ser Phe Val Ser Ser Met Gly Cys 
225                 230                 235                 240 


Asn Val Ser Arg Lys Pro Thr Val Phe Thr Arg Val Ser Ala Tyr Ile 
                245                 250                 255     


Ser Trp Met Asn Asn Val Ile Ala Tyr Asn Ser Glu Gln 
            260                 265                 


