
                                SEQUENCE LISTING

<110> Bionomics Limited

<120> ANTIBODY DRUG CONJUGATES THAT BIND LGR5
  
<130> BIONO.015WO

<150> 62/520726           
<151> 2017-06-16  
  
<160> 49

<170> FastSEQ for Windows Version 4.0

<210> 1
<211> 8
<212> PRT
<213> Mouse

<220> 
<223> 18G7.1 Heavy Chain CDR1 Amino Acid

<400> 1
Gly Tyr Thr Phe Ser Gly Tyr Trp
 1               5              


<210> 2
<211> 8
<212> PRT
<213> Mouse

<220> 
<223> 18G7.1 Heavy Chain CDR2 Amino Acid

<400> 2
Ile Leu Pro Gly Ser Asp Ser Thr
 1               5              


<210> 3
<211> 11
<212> PRT
<213> Mouse

<220> 
<223> 18G7.1 Heavy Chain CDR3 Amino Acid

<400> 3
Ala Arg Ser Gly Tyr Tyr Gly Ser Ser Gln Tyr
 1               5                  10      


<210> 4
<211> 10
<212> PRT
<213> Mouse

<220> 
<223> 18G7.1 Light Chain CDR1 Amino Acid

<400> 4
Glu Ser Val Asp Ser Tyr Gly Asn Ser Phe
 1               5                  10  


<210> 5
<211> 3
<212> PRT
<213> Mouse

<220> 
<223> 18G7.1 Light Chain CDR2 Amino Acid

<400> 5
Leu Thr Ser
 1          


<210> 6
<211> 10
<212> PRT
<213> Mouse

<220> 
<223> 18G7.1 Light Chain CDR3 Amino Acid

<400> 6
Met Gln Gln Asn Asn Glu Asp Pro Arg Thr
 1               5                  10  


<210> 7
<211> 354
<212> DNA
<213> Artifical Sequence

<220> 
<223> 18G7H6A1 Heavy Chain DNA

<400> 7
gaggtgcagc tggtgcagag cggagccgag gtgaagaagc ccggcgagag cctgaggatc 60
agctgcaagg gcagcggcta cagcttcacc gcgtactgga tcgagtgggt gaggcaggct 120
cccggcaagg gcctggagtg gatcggcgag atcctgcccg gcagcgacag caccaactac 180
aacgagaagt tcaagggcca cgtgaccatc agcgccgaca agagcatcag caccgcctac 240
ctgcagtgga gcagcctgaa ggccagcgac accgccgtgt actactgcgc ccgcagcggc 300
tactacggca gcagccagta ctggggccag ggcaccctgg tgaccgtgag cagc       354

<210> 8
<211> 333
<212> DNA
<213> Artificial Sequence

<220> 
<223> 18G7H6A1 Light Chain DNA

<400> 8
gacatcgtgc tgacccagag ccccgccagc ctggccgtga gccccggcca gagggccacc 60
atcacctgcc gcgccagcga gagcgtggac agctacggca acagcttcat gcactggtat 120
cagcagaagc ccggccagcc ccccaagctg ctgatctacc tgaccagcaa cctggagtcc 180
ggcgtgcccg acaggttcag cggcagcggc agcggcaccg acttcaccct gaccatcaac 240
cccgtggagg ccaacgacgc cgccacctac tactgccagc agaacgccga ggaccccagg 300
accttcggcg gcggcaccaa gctggagatc aag                              333

<210> 9
<211> 466
<212> PRT
<213> Artificial Sequence

<220> 
<223> 18G7H6A1 Heavy Chain Amino Acid

<400> 9
Met Glu Trp Ser Trp Val Phe Leu Phe Phe Leu Ser Val Thr Thr Gly
 1               5                  10                  15      
Val His Ser Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys
            20                  25                  30          
Pro Gly Glu Ser Leu Arg Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe
        35                  40                  45              
Thr Ala Tyr Trp Ile Glu Trp Val Arg Gln Ala Pro Gly Lys Gly Leu
    50                  55                  60                  
Glu Trp Ile Gly Glu Ile Leu Pro Gly Ser Asp Ser Thr Asn Tyr Asn
65                  70                  75                  80  
Glu Lys Phe Lys Gly His Val Thr Ile Ser Ala Asp Lys Ser Ile Ser
                85                  90                  95      
Thr Ala Tyr Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Val
            100                 105                 110         
Tyr Tyr Cys Ala Arg Ser Gly Tyr Tyr Gly Ser Ser Gln Tyr Trp Gly
        115                 120                 125             
Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser
    130                 135                 140                 
Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala
145                 150                 155                 160 
Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val
                165                 170                 175     
Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala
            180                 185                 190         
Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val
        195                 200                 205             
Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His
    210                 215                 220                 
Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys
225                 230                 235                 240 
Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly
                245                 250                 255     
Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met
            260                 265                 270         
Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His
        275                 280                 285             
Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val
    290                 295                 300                 
His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr
305                 310                 315                 320 
Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly
                325                 330                 335     
Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile
            340                 345                 350         
Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val
        355                 360                 365             
Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser
    370                 375                 380                 
Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu
385                 390                 395                 400 
Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro
                405                 410                 415     
Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val
            420                 425                 430         
Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met
        435                 440                 445             
His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser
    450                 455                 460                 
Pro Gly
465     


<210> 10
<211> 238
<212> PRT
<213> Artificial Sequence

<220> 
<223> 18G7H6A1 Light Chain Amino Acid

<400> 10
Met Ser Val Pro Thr Gln Val Leu Gly Leu Leu Leu Leu Trp Leu Thr
 1               5                  10                  15      
Asp Ala Arg Cys Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala
            20                  25                  30          
Val Ser Pro Gly Gln Arg Ala Thr Ile Thr Cys Arg Ala Ser Glu Ser
        35                  40                  45              
Val Asp Ser Tyr Gly Asn Ser Phe Met His Trp Tyr Gln Gln Lys Pro
    50                  55                  60                  
Gly Gln Pro Pro Lys Leu Leu Ile Tyr Leu Thr Ser Asn Leu Glu Ser
65                  70                  75                  80  
Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr
                85                  90                  95      
Leu Thr Ile Asn Pro Val Glu Ala Asn Asp Ala Ala Thr Tyr Tyr Cys
            100                 105                 110         
Gln Gln Asn Ala Glu Asp Pro Arg Thr Phe Gly Gly Gly Thr Lys Leu
        115                 120                 125             
Glu Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro
    130                 135                 140                 
Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu
145                 150                 155                 160 
Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn
                165                 170                 175     
Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser
            180                 185                 190         
Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala
        195                 200                 205             
Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly
    210                 215                 220                 
Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys
225                 230                 235             


<210> 11
<211> 1423
<212> DNA
<213> Artificial Sequence

<220> 
<223> 18G7H6A3 Heavy Chain DNA

<400> 11
aagcttgccg ccaccatgga atggtcctgg gtgttcctgt tcttcctgtc cgtgaccacc 60
ggcgtgcact ccgaagtgca gctggtgcag tctggcgccg aagtgaagaa gcctggcgag 120
tccctgcgga tctcctgcaa gggctccggc tactccttca ccgcctactg gattgagtgg 180
gtgcgacagg cccctggcaa gggcctggaa tggatcggag agatcctgcc cggctccgac 240
tccaccaact acaacgagaa gttcaagggc cacgtgacca tctccgccga caagtccatc 300
tctaccgcct acctgcagtg gtcctccctg aaggcctctg acaccgccgt gtactactgc 360
gccagatccg gcctgtacgg ctcctctcag tattggggcc agggcaccct cgtgaccgtg 420
tcctctgctt ctaccaaggg cccaagcgtg ttccccctgg cccccagcag caagagcacc 480
agcggcggca cagccgccct gggctgcctg gtgaaggact acttccccga gcccgtgacc 540
gtgtcctgga acagcggagc cctgacctcc ggcgtgcaca ccttccccgc cgtgctgcag 600
agcagcggcc tgtacagcct gagcagcgtg gtgaccgtgc ccagcagcag cctgggcacc 660
cagacctaca tctgtaacgt gaaccacaag cccagcaaca ccaaggtgga caagaaggtg 720
gagcccaaga gctgtgacaa gacccacacc tgccccccct gcccagcccc cgagctgctg 780
ggcggaccca gcgtgttcct gttccccccc aagcccaagg acaccctgat gatcagcaga 840
acccccgagg tgacctgtgt ggtggtggac gtgtcccacg aggacccaga ggtgaagttc 900
aactggtacg tggacggcgt ggaggtgcac aacgccaaga ccaagcccag agaggagcag 960
tacaacagca cctacagggt ggtgtccgtg ctgaccgtgc tgcaccagga ctggctgaac 1020
ggcaaggagt acaagtgtaa ggtgtccaac aaggccctgc cagccccaat cgaaaagacc 1080
atcagcaagg ccaagggcca gccaagagag ccccaggtgt acaccctgcc acccagcagg 1140
gacgagctga ccaagaacca ggtgtccctg acctgtctgg tgaagggctt ctacccaagc 1200
gacatcgccg tggagtggga gagcaacggc cagcccgaga acaactacaa gaccaccccc 1260
ccagtgctgg acagcgacgg cagcttcttc ctgtacagca agctgaccgt ggacaagagc 1320
agatggcagc agggcaacgt gttcagctgc tccgtgatgc acgaggccct gcacaaccac 1380
tacacccaga agagcctgag cctgtcccca ggctgatgaa ttc                   1423

<210> 12
<211> 739
<212> DNA
<213> Artificial Sequence

<220> 
<223> 18G7H6A3 Light Chain DNA

<400> 12
aagcttgccg ccaccatgtc cgtgcctacc caggtgctgg gactgctgct gctgtggctg 60
accgacgcca gatgcgacat cgtgctgacc cagagccctg cctctctggc tgtgtctcct 120
ggccagaggg ccaccatcac ctgtagagcc tccgagtccg tggactccta cggcaactcc 180
ttcatgcact ggtatcagca gaagcccggc cagcccccca agctgctgat ctacctgacc 240
tccaacctgg aatccggcgt gcccgacaga ttctccggct ctggctctgg caccgacttc 300
accctgacca tcaaccccgt ggaagccaac gacgccgcca cctactactg ccagcagaac 360
gccgaggacc ccagaacctt tggcggaggc accaagctgg aaatcaagcg tacggtggcc 420
gctcccagcg tgttcatctt ccccccaagc gacgagcagc tgaagagcgg caccgccagc 480
gtggtgtgtc tgctgaacaa cttctacccc agggaggcca aggtgcagtg gaaggtggac 540
aacgccctgc agagcggcaa cagccaggag agcgtcaccg agcaggacag caaggactcc 600
acctacagcc tgagcagcac cctgaccctg agcaaggccg actacgagaa gcacaaggtg 660
tacgcctgtg aggtgaccca ccagggcctg tccagccccg tgaccaagag cttcaacagg 720
ggcgagtgct gatgaattc                                              739

<210> 13
<211> 466
<212> PRT
<213> Artificial Sequence

<220> 
<223> 18G7H6A3 Heavy Chain Amino Acid

<400> 13
Met Glu Trp Ser Trp Val Phe Leu Phe Phe Leu Ser Val Thr Thr Gly
 1               5                  10                  15      
Val His Ser Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys
            20                  25                  30          
Pro Gly Glu Ser Leu Arg Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe
        35                  40                  45              
Thr Ala Tyr Trp Ile Glu Trp Val Arg Gln Ala Pro Gly Lys Gly Leu
    50                  55                  60                  
Glu Trp Ile Gly Glu Ile Leu Pro Gly Ser Asp Ser Thr Asn Tyr Asn
65                  70                  75                  80  
Glu Lys Phe Lys Gly His Val Thr Ile Ser Ala Asp Lys Ser Ile Ser
                85                  90                  95      
Thr Ala Tyr Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Val
            100                 105                 110         
Tyr Tyr Cys Ala Arg Ser Gly Leu Tyr Gly Ser Ser Gln Tyr Trp Gly
        115                 120                 125             
Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser
    130                 135                 140                 
Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala
145                 150                 155                 160 
Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val
                165                 170                 175     
Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala
            180                 185                 190         
Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val
        195                 200                 205             
Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His
    210                 215                 220                 
Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys
225                 230                 235                 240 
Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly
                245                 250                 255     
Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met
            260                 265                 270         
Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His
        275                 280                 285             
Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val
    290                 295                 300                 
His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr
305                 310                 315                 320 
Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly
                325                 330                 335     
Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile
            340                 345                 350         
Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val
        355                 360                 365             
Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser
    370                 375                 380                 
Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu
385                 390                 395                 400 
Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro
                405                 410                 415     
Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val
            420                 425                 430         
Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met
        435                 440                 445             
His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser
    450                 455                 460                 
Pro Gly
465     


<210> 14
<211> 238
<212> PRT
<213> Artificial Sequence

<220> 
<223> 18G7H6A3 Light Chain Amino Acid

<400> 14
Met Ser Val Pro Thr Gln Val Leu Gly Leu Leu Leu Leu Trp Leu Thr
 1               5                  10                  15      
Asp Ala Arg Cys Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala
            20                  25                  30          
Val Ser Pro Gly Gln Arg Ala Thr Ile Thr Cys Arg Ala Ser Glu Ser
        35                  40                  45              
Val Asp Ser Tyr Gly Asn Ser Phe Met His Trp Tyr Gln Gln Lys Pro
    50                  55                  60                  
Gly Gln Pro Pro Lys Leu Leu Ile Tyr Leu Thr Ser Asn Leu Glu Ser
65                  70                  75                  80  
Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr
                85                  90                  95      
Leu Thr Ile Asn Pro Val Glu Ala Asn Asp Ala Ala Thr Tyr Tyr Cys
            100                 105                 110         
Gln Gln Asn Ala Glu Asp Pro Arg Thr Phe Gly Gly Gly Thr Lys Leu
        115                 120                 125             
Glu Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro
    130                 135                 140                 
Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu
145                 150                 155                 160 
Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn
                165                 170                 175     
Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser
            180                 185                 190         
Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala
        195                 200                 205             
Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly
    210                 215                 220                 
Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys
225                 230                 235             


<210> 15
<211> 354
<212> DNA
<213> Artificial Sequence

<220> 
<223> 18G7Ch Heavy Chain DNA

<400> 15
caggttcagc tgcagcagtc tggagctgag ctggtgaagc ctggggcctc agtgaagata 60
tcctgcaagg ctactggcta cacattcagt ggctactgga tagagtgggt aaagcagagg 120
cctggacatg gccttgagtg gattggagag attttgcctg gaagtgatag tactaactac 180
aatgagaagt tcaagggcaa ggccacattc actgcagata catcctccaa cacagtctac 240
atgcaattca gcagcctgac atctgaggac tctgccgtct attactgtgc aagatcgggt 300
tactacggta gtagtcagta ctggggccaa ggcaccactc tcacagtctc ctca       354

<210> 16
<211> 334
<212> DNA
<213> Artificial Sequence

<220> 
<223> 18G7Ch Light Chain DNA

<400> 16
aacattgtgc tgacccaatc tcctgcttct ttggctgtgt ctctagggca gagggccacc 60
atatcctgca gagccagtga aagtgttgat agttatggca atagttttat gcactggtac 120
cagcagaaac caggacagcc acccaaactc ctcatctatc ttacatccaa cctagaatct 180
ggggtccctg ccaggttcag tggcagtggg tctaggacag acttcaccct caccattgat 240
cctgtggagg ctgatgatgc tgcaacctat tactgtcagc aaaataatga ggatcctcgg 300
acgttcggtg gaggcaccaa gctggaaatc aaac                             334

<210> 17
<211> 466
<212> PRT
<213> Artificial Sequence

<220> 
<223> 18G7Ch Heavy Chain Amino Acid

<400> 17
Met Glu Trp Ser Trp Val Phe Leu Phe Phe Leu Ser Val Thr Thr Gly
 1               5                  10                  15      
Val His Ser Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Lys
            20                  25                  30          
Pro Gly Ala Ser Val Lys Ile Ser Cys Lys Ala Thr Gly Tyr Thr Phe
        35                  40                  45              
Ser Gly Tyr Trp Ile Glu Trp Val Lys Gln Arg Pro Gly His Gly Leu
    50                  55                  60                  
Glu Trp Ile Gly Glu Ile Leu Pro Gly Ser Asp Ser Thr Asn Tyr Asn
65                  70                  75                  80  
Glu Lys Phe Lys Gly Lys Ala Thr Phe Thr Ala Asp Thr Ser Ser Asn
                85                  90                  95      
Thr Val Tyr Met Gln Phe Ser Ser Leu Thr Ser Glu Asp Ser Ala Val
            100                 105                 110         
Tyr Tyr Cys Ala Arg Ser Gly Tyr Tyr Gly Ser Ser Gln Tyr Trp Gly
        115                 120                 125             
Gln Gly Thr Thr Leu Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser
    130                 135                 140                 
Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala
145                 150                 155                 160 
Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val
                165                 170                 175     
Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala
            180                 185                 190         
Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val
        195                 200                 205             
Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His
    210                 215                 220                 
Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys
225                 230                 235                 240 
Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly
                245                 250                 255     
Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met
            260                 265                 270         
Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His
        275                 280                 285             
Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val
    290                 295                 300                 
His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr
305                 310                 315                 320 
Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly
                325                 330                 335     
Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile
            340                 345                 350         
Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val
        355                 360                 365             
Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser
    370                 375                 380                 
Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu
385                 390                 395                 400 
Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro
                405                 410                 415     
Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val
            420                 425                 430         
Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met
        435                 440                 445             
His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser
    450                 455                 460                 
Pro Gly
465     


<210> 18
<211> 238
<212> PRT
<213> Artificial Sequence

<220> 
<223> 18G7ch Light Chain Amino Acid

<400> 18
Met Ser Val Pro Thr Gln Val Leu Gly Leu Leu Leu Leu Trp Leu Thr
 1               5                  10                  15      
Asp Ala Arg Cys Asn Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala
            20                  25                  30          
Val Ser Leu Gly Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser
        35                  40                  45              
Val Asp Ser Tyr Gly Asn Ser Phe Met His Trp Tyr Gln Gln Lys Pro
    50                  55                  60                  
Gly Gln Pro Pro Lys Leu Leu Ile Tyr Leu Thr Ser Asn Leu Glu Ser
65                  70                  75                  80  
Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Arg Thr Asp Phe Thr
                85                  90                  95      
Leu Thr Ile Asp Pro Val Glu Ala Asp Asp Ala Ala Thr Tyr Tyr Cys
            100                 105                 110         
Gln Gln Asn Asn Glu Asp Pro Arg Thr Phe Gly Gly Gly Thr Lys Leu
        115                 120                 125             
Glu Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro
    130                 135                 140                 
Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu
145                 150                 155                 160 
Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn
                165                 170                 175     
Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser
            180                 185                 190         
Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala
        195                 200                 205             
Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly
    210                 215                 220                 
Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys
225                 230                 235             


<210> 19
<211> 137
<212> PRT
<213> Artificial Sequence

<220> 
<223> 18G7H6A3 Heavy Chain Variable Domain Amino Acid

<400> 19
Met Glu Trp Ser Trp Val Phe Leu Phe Phe Leu Ser Val Thr Thr Gly
 1               5                  10                  15      
Val His Ser Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys
            20                  25                  30          
Pro Gly Glu Ser Leu Arg Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe
        35                  40                  45              
Thr Ala Tyr Trp Ile Glu Trp Val Arg Gln Ala Pro Gly Lys Gly Leu
    50                  55                  60                  
Glu Trp Ile Gly Glu Ile Leu Pro Gly Ser Asp Ser Thr Asn Tyr Asn
65                  70                  75                  80  
Glu Lys Phe Lys Gly His Val Thr Ile Ser Ala Asp Lys Ser Ile Ser
                85                  90                  95      
Thr Ala Tyr Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Val
            100                 105                 110         
Tyr Tyr Cys Ala Arg Ser Gly Tyr Tyr Gly Ser Ser Gln Tyr Trp Gly
        115                 120                 125             
Gln Gly Thr Leu Val Thr Val Ser Ser
    130                 135         


<210> 20
<211> 411
<212> DNA
<213> Artificial Sequence

<220> 
<223> 18G7H6A3 Heavy Chain Variable Domain DNA

<400> 20
atggaatggt cctgggtgtt cctgttcttc ctgtccgtga ccaccggcgt gcactccgaa 60
gtgcagctgg tgcagtctgg cgccgaagtg aagaagcctg gcgagtccct gcggatctcc 120
tgcaagggct ccggctactc cttcaccgcc tactggattg agtgggtgcg acaggcccct 180
ggcaagggcc tggaatggat cggagagatc ctgcccggct ccgactccac caactacaac 240
gagaagttca agggccacgt gaccatctcc gccgacaagt ccatctctac cgcctacctg 300
cagtggtcct ccctgaaggc ctctgacacc gccgtgtact actgcgccag atccggcctg 360
tacggctcct ctcagtattg gggccagggc accctcgtga ccgtgtcctc t          411

<210> 21
<211> 131
<212> PRT
<213> Artificial Sequence

<220> 
<223> 18G7H6A3 Light Chain Variable Domain

<400> 21
Met Ser Val Pro Thr Gln Val Leu Gly Leu Leu Leu Leu Trp Leu Thr
 1               5                  10                  15      
Asp Ala Arg Cys Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala
            20                  25                  30          
Val Ser Pro Gly Gln Arg Ala Thr Ile Thr Cys Arg Ala Ser Glu Ser
        35                  40                  45              
Val Asp Ser Tyr Gly Asn Ser Phe Met His Trp Tyr Gln Gln Lys Pro
    50                  55                  60                  
Gly Gln Pro Pro Lys Leu Leu Ile Tyr Leu Thr Ser Asn Leu Glu Ser
65                  70                  75                  80  
Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr
                85                  90                  95      
Leu Thr Ile Asn Pro Val Glu Ala Asn Asp Ala Ala Thr Tyr Tyr Cys
            100                 105                 110         
Gln Gln Asn Ala Glu Asp Pro Arg Thr Phe Gly Gly Gly Thr Lys Leu
        115                 120                 125             
Glu Ile Lys
    130     


<210> 22
<211> 393
<212> DNA
<213> Artificial Sequence

<220> 
<223> 18G7H6A3 Light Chain Variable Domain DNA

<400> 22
atgtccgtgc ctacccaggt gctgggactg ctgctgctgt ggctgaccga cgccagatgc 60
gacatcgtgc tgacccagag ccctgcctct ctggctgtgt ctcctggcca gagggccacc 120
atcacctgta gagcctccga gtccgtggac tcctacggca actccttcat gcactggtat 180
cagcagaagc ccggccagcc ccccaagctg ctgatctacc tgacctccaa cctggaatcc 240
ggcgtgcccg acagattctc cggctctggc tctggcaccg acttcaccct gaccatcaac 300
cccgtggaag ccaacgacgc cgccacctac tactgccagc agaacgccga ggaccccaga 360
acctttggcg gaggcaccaa gctggaaatc aag                              393

<210> 23
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> 18G7H6A3 Heavy Chain CDR1 Amino Acid

<400> 23
Gly Tyr Ser Phe Thr Ala Tyr Trp
 1               5              


<210> 24
<211> 24
<212> DNA
<213> Artificial Sequence

<220> 
<223> 18G7H6A3 Heavy Chain CDR1 DNA

<400> 24
ggctactcct tcaccgccta ctgg                                        24

<210> 25
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> 18G7H6A3 Heavy Chain CDR2 Amino Acid

<400> 25
Ile Leu Pro Gly Ser Asp Ser Thr
 1               5              


<210> 26
<211> 24
<212> DNA
<213> Artificial Sequence

<220> 
<223> 18G7H6A3 Heavy Chain CDR2 DNA

<400> 26
atcctgcccg gctccgactc cacc                                        24

<210> 27
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> 18G7H6A3 Heavy Chain CDR3 Amino Acid

<400> 27
Ala Arg Ser Gly Tyr Tyr Gly Ser Ser Gln Tyr
 1               5                  10      


<210> 28
<211> 33
<212> DNA
<213> Artificial Sequence

<220> 
<223> 18G7H6A3 Heavy Chain CDR3 DNA

<400> 28
gccagatccg gcctgtacgg ctcctctcag tat                              33

<210> 29
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> 18G7H6A3 Light Chain CDR1 Amino Acid

<400> 29
Glu Ser Val Asp Ser Tyr Gly Asn Ser Phe
 1               5                  10  


<210> 30
<211> 30
<212> DNA
<213> Artificial Sequence

<220> 
<223> 18G7H6A3 Light Chain CDR1 DNA

<400> 30
gagtccgtgg actcctacgg caactccttc                                  30

<210> 31
<211> 3
<212> PRT
<213> Artificial Sequence

<220> 
<223> 18G7H6A3 Light Chain CDR2 Amino Acid

<400> 31
Leu Thr Ser
 1          


<210> 32
<211> 9
<212> DNA
<213> Artificial Sequence

<220> 
<223> 18G7H6A3 Light Chain CDR2 DNA

<400> 32
ctgacctcc                                                         9

<210> 33
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> 18G7H6A3 Light Chain CDR3 Amino Acid

<400> 33
Gln Gln Asn Ala Glu Asp Pro Arg Thr
 1               5                  


<210> 34
<211> 27
<212> DNA
<213> Artificial Sequence

<220> 
<223> 18G7H6A3 Light Chain CDR3 DNA

<400> 34
cagcagaacg ccgaggaccc cagaacc                                     27

<210> 35
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> 18G7H6A1 Heavy Chain CDR1 Amino Acid

<400> 35
Gly Tyr Ser Phe Thr Ala Tyr Trp
 1               5              


<210> 36
<211> 24
<212> DNA
<213> Artificial Sequence

<220> 
<223> 18G7H6A1 Heavy Chain CDR1 DNA

<400> 36
ggctactcct tcaccgccta ctgg                                        24

<210> 37
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> 18G7H6A1 Heavy Chain CDR2 Amino Acid

<400> 37
Ile Leu Pro Gly Ser Asp Ser Thr
 1               5              


<210> 38
<211> 24
<212> DNA
<213> Artificial Sequence

<220> 
<223> 18G7H6A1 Heavy Chain CDR2 DNA

<400> 38
atcctgcccg gcagcgacag cacc                                        24

<210> 39
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> 18G7H6A1 Heavy Chain CDR3 Amino Acid

<400> 39
Ala Arg Ser Gly Tyr Tyr Gly Ser Ser Gln Tyr
 1               5                  10      


<210> 40
<211> 33
<212> DNA
<213> Artificial Sequence

<220> 
<223> 18G7H6A1 Heavy Chain CDR3 DNA

<400> 40
gcccgcagcg gctactacgg cagcagccag tac                              33

<210> 41
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> 18G7H6A1 Light Chain CDR1 Amino Acid

<400> 41
Glu Ser Val Asp Ser Tyr Gly Asn Ser Phe
 1               5                  10  


<210> 42
<211> 30
<212> DNA
<213> Artificial Sequence

<220> 
<223> 18G7H6A1 Light Chain CDR1 DNA

<400> 42
gagagcgtgg acagctacgg caacagcttc                                  30

<210> 43
<211> 3
<212> PRT
<213> Artificial Sequence

<220> 
<223> 18G7H6A1 Light Chain CDR2 Amino Acid

<400> 43
Leu Thr Ser
 1          


<210> 44
<211> 9
<212> DNA
<213> Artificial Sequence

<220> 
<223> 18G7H6A1 Light Chain CDR2 DNA

<400> 44
ctgaccagc                                                         9

<210> 45
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> 18G7H6A1 Light Chain CDR3 Amino Acid

<400> 45
Gln Gln Asn Ala Glu Asp Pro Arg Thr
 1               5                  


<210> 46
<211> 27
<212> DNA
<213> Artificial Sequence

<220> 
<223> 18G7H6A1 Light Chain CDR3 DNA

<400> 46
cagcagaacg ccgaggaccc caggacc                                     27

<210> 47
<211> 561
<212> PRT
<213> Homo Sapiens

<400> 47
Met Asp Thr Ser Arg Leu Gly Val Leu Leu Ser Leu Pro Val Leu Leu
 1               5                  10                  15      
Gln Leu Ala Thr Gly Gly Ser Ser Pro Arg Ser Gly Val Leu Leu Arg
            20                  25                  30          
Gly Cys Pro Thr His Cys His Cys Glu Pro Asp Gly Arg Met Leu Leu
        35                  40                  45              
Arg Val Asp Cys Ser Asp Leu Gly Leu Ser Glu Leu Pro Ser Asn Leu
    50                  55                  60                  
Ser Val Phe Thr Ser Tyr Leu Asp Leu Ser Met Asn Asn Ile Ser Gln
65                  70                  75                  80  
Leu Leu Pro Asn Pro Leu Pro Ser Leu Arg Phe Leu Glu Glu Leu Arg
                85                  90                  95      
Leu Ala Gly Asn Ala Leu Thr Tyr Ile Pro Lys Gly Ala Phe Thr Gly
            100                 105                 110         
Leu Tyr Ser Leu Lys Val Leu Met Leu Gln Asn Asn Gln Leu Arg His
        115                 120                 125             
Val Pro Thr Glu Ala Leu Gln Asn Leu Arg Ser Leu Gln Ser Leu Arg
    130                 135                 140                 
Leu Asp Ala Asn His Ile Ser Tyr Val Pro Pro Ser Cys Phe Ser Gly
145                 150                 155                 160 
Leu His Ser Leu Arg His Leu Trp Leu Asp Asp Asn Ala Leu Thr Glu
                165                 170                 175     
Ile Pro Val Gln Ala Phe Arg Ser Leu Ser Ala Leu Gln Ala Met Thr
            180                 185                 190         
Leu Ala Leu Asn Lys Ile His His Ile Pro Asp Tyr Ala Phe Gly Asn
        195                 200                 205             
Leu Ser Ser Leu Val Val Leu His Leu His Asn Asn Arg Ile His Ser
    210                 215                 220                 
Leu Gly Lys Lys Cys Phe Asp Gly Leu His Ser Leu Glu Thr Leu Asp
225                 230                 235                 240 
Leu Asn Tyr Asn Asn Leu Asp Glu Phe Pro Thr Ala Ile Arg Thr Leu
                245                 250                 255     
Ser Asn Leu Lys Glu Leu Gly Phe His Ser Asn Asn Ile Arg Ser Ile
            260                 265                 270         
Pro Glu Lys Ala Phe Val Gly Asn Pro Ser Leu Ile Thr Ile His Phe
        275                 280                 285             
Tyr Asp Asn Pro Ile Gln Phe Val Gly Arg Ser Ala Phe Gln His Leu
    290                 295                 300                 
Pro Glu Leu Arg Thr Leu Thr Leu Asn Gly Ala Ser Gln Ile Thr Glu
305                 310                 315                 320 
Phe Pro Asp Leu Thr Gly Thr Ala Asn Leu Glu Ser Leu Thr Leu Thr
                325                 330                 335     
Gly Ala Gln Ile Ser Ser Leu Pro Gln Thr Val Cys Asn Gln Leu Pro
            340                 345                 350         
Asn Leu Gln Val Leu Asp Leu Ser Tyr Asn Leu Leu Glu Asp Leu Pro
        355                 360                 365             
Ser Phe Ser Val Cys Gln Lys Leu Gln Lys Ile Asp Leu Arg His Asn
    370                 375                 380                 
Glu Ile Tyr Glu Ile Lys Val Asp Thr Phe Gln Gln Leu Leu Ser Leu
385                 390                 395                 400 
Arg Ser Leu Asn Leu Ala Trp Asn Lys Ile Ala Ile Ile His Pro Asn
                405                 410                 415     
Ala Phe Ser Thr Leu Pro Ser Leu Ile Lys Leu Asp Leu Ser Ser Asn
            420                 425                 430         
Leu Leu Ser Ser Phe Pro Ile Thr Gly Leu His Gly Leu Thr His Leu
        435                 440                 445             
Lys Leu Thr Gly Asn His Ala Leu Gln Ser Leu Ile Ser Ser Glu Asn
    450                 455                 460                 
Phe Pro Glu Leu Lys Val Ile Glu Met Pro Tyr Ala Tyr Gln Cys Cys
465                 470                 475                 480 
Ala Phe Gly Val Cys Glu Asn Ala Tyr Lys Ile Ser Asn Gln Trp Asn
                485                 490                 495     
Lys Gly Asp Asn Ser Ser Met Asp Asp Leu His Lys Lys Asp Ala Gly
            500                 505                 510         
Met Phe Gln Ala Gln Asp Glu Arg Asp Leu Glu Asp Phe Leu Leu Asp
        515                 520                 525             
Phe Glu Glu Asp Leu Lys Ala Leu His Ser Val Gln Cys Ser Pro Ser
    530                 535                 540                 
Pro Gly Pro Phe Lys Pro Cys Glu His Leu Leu Asp Gly Trp Leu Ile
545                 550                 555                 560 
Arg
    


<210> 48
<211> 137
<212> PRT
<213> Artificial Sequence

<220> 
<223> 18G7H6A1 Heavy Chain Variable Amino acid

<400> 48
Met Glu Trp Ser Trp Val Phe Leu Phe Phe Leu Ser Val Thr Thr Gly
 1               5                  10                  15      
Val His Ser Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys
            20                  25                  30          
Pro Gly Glu Ser Leu Arg Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe
        35                  40                  45              
Thr Ala Tyr Trp Ile Glu Trp Val Arg Gln Ala Pro Gly Lys Gly Leu
    50                  55                  60                  
Glu Trp Ile Gly Glu Ile Leu Pro Gly Ser Asp Ser Thr Asn Tyr Asn
65                  70                  75                  80  
Glu Lys Phe Lys Gly His Val Thr Ile Ser Ala Asp Lys Ser Ile Ser
                85                  90                  95      
Thr Ala Tyr Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Val
            100                 105                 110         
Tyr Tyr Cys Ala Arg Ser Gly Tyr Tyr Gly Ser Ser Gln Tyr Trp Gly
        115                 120                 125             
Gln Gly Thr Leu Val Thr Val Ser Ser
    130                 135         


<210> 49
<211> 131
<212> PRT
<213> Artificial Sequence

<220> 
<223> 18G7H6A1 Light Chain Variable Amino acid

<400> 49
Met Ser Val Pro Thr Gln Val Leu Gly Leu Leu Leu Leu Trp Leu Thr
 1               5                  10                  15      
Asp Ala Arg Cys Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala
            20                  25                  30          
Val Ser Pro Gly Gln Arg Ala Thr Ile Thr Cys Arg Ala Ser Glu Ser
        35                  40                  45              
Val Asp Ser Tyr Gly Asn Ser Phe Met His Trp Tyr Gln Gln Lys Pro
    50                  55                  60                  
Gly Gln Pro Pro Lys Leu Leu Ile Tyr Leu Thr Ser Asn Leu Glu Ser
65                  70                  75                  80  
Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr
                85                  90                  95      
Leu Thr Ile Asn Pro Val Glu Ala Asn Asp Ala Ala Thr Tyr Tyr Cys
            100                 105                 110         
Gln Gln Asn Ala Glu Asp Pro Arg Thr Phe Gly Gly Gly Thr Lys Leu
        115                 120                 125             
Glu Ile Lys
    130     

