                         SEQUENCE LISTING

<110>  Regents of the University of Minnesota
 
<120>  Increasing Gene Editing Frequency

<130>  09531-0376WO1

<150>  US 62/518,960
<151>  2017-06-13

<160>  24    

<170>  PatentIn version 3.5

<210>  1
<211>  116
<212>  PRT
<213>  Porcine circovirus 2

<400>  1

Ser Pro Ser Lys Lys Asn Gly Arg Ser Gly Pro Gln Pro His Lys Arg 
1               5                   10                  15      


Trp Val Phe Thr Leu Asn Asn Pro Ser Glu Asp Glu Arg Lys Lys Ile 
            20                  25                  30          


Arg Asp Leu Pro Ile Ser Leu Phe Asp Tyr Phe Ile Val Gly Glu Glu 
        35                  40                  45              


Gly Asn Glu Glu Gly Arg Thr Pro His Leu Gln Gly Phe Ala Asn Phe 
    50                  55                  60                  


Val Lys Lys Gln Thr Phe Asn Lys Val Lys Trp Tyr Leu Gly Ala Arg 
65                  70                  75                  80  


Cys His Ile Glu Lys Ala Lys Gly Thr Asp Gln Gln Asn Lys Glu Tyr 
                85                  90                  95      


Cys Ser Lys Glu Gly Asn Leu Leu Met Glu Cys Gly Ala Pro Arg Ser 
            100                 105                 110         


Gln Gly Gln Arg 
        115     


<210>  2
<211>  340
<212>  PRT
<213>  Bacteriophage PhiX174

<400>  2

Lys Ser Arg Arg Gly Phe Ala Ile Gln Arg Leu Met Asn Ala Met Arg 
1               5                   10                  15      


Gln Ala His Ala Asp Gly Trp Phe Ile Val Phe Asp Thr Leu Thr Leu 
            20                  25                  30          


Ala Asp Asp Arg Leu Glu Ala Phe Tyr Asp Asn Pro Asn Ala Leu Arg 
        35                  40                  45              


Asp Tyr Phe Arg Asp Ile Gly Arg Met Val Leu Ala Ala Glu Gly Arg 
    50                  55                  60                  


Lys Ala Asn Asp Ser His Ala Asp Cys Tyr Gln Tyr Phe Cys Val Pro 
65                  70                  75                  80  


Glu Tyr Gly Thr Ala Asn Gly Arg Leu His Phe His Ala Val His Phe 
                85                  90                  95      


Met Arg Thr Leu Pro Thr Gly Ser Val Asp Pro Asn Phe Gly Arg Arg 
            100                 105                 110         


Val Arg Asn Arg Arg Gln Leu Asn Ser Leu Gln Asn Thr Trp Pro Tyr 
        115                 120                 125             


Gly His Ser Met Pro Ile Ala Val Arg Tyr Thr Gln Asp Ala Phe Ser 
    130                 135                 140                 


Arg Ser Gly Trp Leu Trp Pro Val Asp Ala Lys Gly Glu Pro Leu Lys 
145                 150                 155                 160 


Ala Thr Ser Tyr Met Ala Val Gly Phe Tyr Val Ala Lys Tyr Val Asn 
                165                 170                 175     


Lys Lys Ser Asp Met Asp Leu Ala Ala Lys Gly Leu Gly Ala Lys Glu 
            180                 185                 190         


Trp Asn Asn Ser Leu Lys Thr Lys Leu Ser Leu Leu Pro Lys Lys Leu 
        195                 200                 205             


Phe Arg Ile Arg Met Ser Arg Asn Phe Gly Met Lys Met Leu Thr Met 
    210                 215                 220                 


Thr Asn Leu Ser Thr Glu Cys Leu Ile Gln Leu Thr Lys Leu Gly Tyr 
225                 230                 235                 240 


Asp Ala Thr Pro Phe Asn Gln Ile Leu Lys Gln Asn Ala Lys Arg Glu 
                245                 250                 255     


Met Arg Leu Arg Leu Gly Lys Val Thr Val Ala Asp Val Leu Ala Ala 
            260                 265                 270         


Gln Pro Val Thr Thr Asn Leu Leu Lys Phe Met Arg Ala Ser Ile Lys 
        275                 280                 285             


Met Ile Gly Val Ser Asn Leu Gln Ser Phe Ile Ala Ser Met Thr Gln 
    290                 295                 300                 


Lys Leu Thr Leu Ser Asp Ile Ser Asp Glu Ser Lys Asn Tyr Leu Asp 
305                 310                 315                 320 


Lys Ala Gly Ile Thr Thr Ala Cys Leu Arg Ile Lys Ser Lys Trp Thr 
                325                 330                 335     


Ala Gly Gly Lys 
            340 


<210>  3
<211>  186
<212>  PRT
<213>  Escherichia coli

<400>  3

Met Ala Ile Tyr His Leu Thr Ala Lys Thr Gly Ser Arg Ser Gly Gly 
1               5                   10                  15      


Gln Ser Ala Arg Ala Lys Ala Asp Tyr Ile Gln Arg Glu Gly Lys Tyr 
            20                  25                  30          


Ala Arg Asp Met Asp Glu Val Leu His Ala Glu Ser Gly His Met Pro 
        35                  40                  45              


Glu Phe Val Glu Arg Pro Ala Asp Tyr Trp Asp Ala Ala Asp Leu Tyr 
    50                  55                  60                  


Glu Arg Ala Asn Gly Arg Leu Phe Lys Glu Val Glu Phe Ala Leu Pro 
65                  70                  75                  80  


Val Glu Leu Thr Leu Asp Gln Gln Lys Ala Leu Ala Ser Glu Phe Ala 
                85                  90                  95      


Gln His Leu Thr Gly Ala Glu Arg Leu Pro Tyr Thr Leu Ala Ile His 
            100                 105                 110         


Ala Gly Gly Gly Glu Asn Pro His Cys His Leu Met Ile Ser Glu Arg 
        115                 120                 125             


Ile Asn Asp Gly Ile Glu Arg Pro Ala Ala Gln Trp Phe Lys Arg Tyr 
    130                 135                 140                 


Asn Gly Lys Thr Pro Glu Lys Gly Gly Ala Gln Lys Thr Glu Ala Leu 
145                 150                 155                 160 


Lys Pro Lys Ala Trp Leu Glu Gln Thr Arg Glu Ala Trp Ala Asp His 
                165                 170                 175     


Ala Asn Arg Ala Leu Glu Arg Ala Gly His 
            180                 185     


<210>  4
<211>  330
<212>  PRT
<213>  Escherichia coli

<400>  4

Met Met Ser Ile Ala Gln Val Arg Ser Ala Gly Ser Ala Gly Asn Tyr 
1               5                   10                  15      


Tyr Thr Asp Lys Asp Asn Tyr Tyr Val Leu Gly Ser Met Gly Glu Arg 
            20                  25                  30          


Trp Ala Gly Arg Gly Ala Glu Gln Leu Gly Leu Gln Gly Ser Val Asp 
        35                  40                  45              


Lys Asp Val Phe Thr Arg Leu Leu Glu Gly Arg Leu Pro Asp Gly Ala 
    50                  55                  60                  


Asp Leu Ser Arg Met Gln Asp Gly Ser Asn Arg His Arg Pro Gly Tyr 
65                  70                  75                  80  


Asp Leu Thr Phe Ser Ala Pro Lys Ser Val Ser Met Met Ala Met Leu 
                85                  90                  95      


Gly Gly Asp Lys Arg Leu Ile Asp Ala His Asn Gln Ala Val Asp Phe 
            100                 105                 110         


Ala Val Arg Gln Val Glu Ala Leu Ala Ser Thr Arg Val Met Thr Asp 
        115                 120                 125             


Gly Gln Ser Glu Thr Val Leu Thr Gly Asn Leu Val Met Ala Leu Phe 
    130                 135                 140                 


Asn His Asp Thr Ser Arg Asp Gln Glu Pro Gln Leu His Thr His Ala 
145                 150                 155                 160 


Val Val Ala Asn Val Thr Gln His Asn Gly Glu Trp Lys Thr Leu Ser 
                165                 170                 175     


Ser Asp Lys Val Gly Lys Thr Gly Phe Ile Glu Asn Val Tyr Ala Asn 
            180                 185                 190         


Gln Ile Ala Phe Gly Arg Leu Tyr Arg Glu Lys Leu Lys Glu Gln Val 
        195                 200                 205             


Glu Ala Leu Gly Tyr Glu Thr Glu Val Val Gly Lys His Gly Met Trp 
    210                 215                 220                 


Glu Met Pro Gly Val Pro Val Glu Ala Phe Ser Gly Arg Ser Gln Thr 
225                 230                 235                 240 


Ile Arg Glu Ala Val Gly Glu Asp Ala Ser Leu Lys Ser Arg Asp Val 
                245                 250                 255     


Ala Ala Leu Asp Thr Arg Lys Ser Lys Gln His Val Asp Pro Glu Ile 
            260                 265                 270         


Lys Met Ala Glu Trp Met Gln Thr Leu Lys Glu Thr Gly Phe Asp Ile 
        275                 280                 285             


Arg Ala Tyr Arg Asp Ala Ala Asp Gln Arg Ala Asp Leu Arg Thr Leu 
    290                 295                 300                 


Thr Pro Gly Pro Ala Ser Gln Asp Gly Pro Asp Val Gln Gln Ala Val 
305                 310                 315                 320 


Thr Gln Ala Ile Ala Gly Leu Ser Glu Arg 
                325                 330 


<210>  5
<211>  133
<212>  PRT
<213>  Streptococcus agalactiae

<400>  5

Met Ala Lys Glu Lys Ala Arg Tyr Phe Thr Phe Leu Leu Tyr Pro Glu 
1               5                   10                  15      


Ser Ile Pro Ser Asp Trp Glu Leu Lys Leu Glu Thr Leu Gly Val Pro 
            20                  25                  30          


Met Ala Ile Ser Pro Leu His Asp Lys Asp Lys Ser Ser Ile Lys Gly 
        35                  40                  45              


Gln Lys Tyr Lys Lys Ala His Tyr His Val Leu Tyr Ile Ala Lys Asn 
    50                  55                  60                  


Pro Val Thr Ala Asp Ser Val Arg Lys Lys Ile Lys Leu Leu Leu Gly 
65                  70                  75                  80  


Glu Lys Ser Leu Ala Met Val Gln Val Val Leu Asn Val Glu Asn Met 
                85                  90                  95      


Tyr Leu Tyr Leu Thr His Glu Ser Lys Asp Ala Ile Ala Lys Lys Lys 
            100                 105                 110         


His Val Tyr Asp Lys Ala Asp Ile Lys Leu Ile Asn Asn Phe Asp Ile 
        115                 120                 125             


Asp Arg Tyr Leu Glu 
    130             


<210>  6
<211>  130
<212>  PRT
<213>  Streptococcus pneumonia

<400>  6

Met Ser Glu Lys Lys Glu Ile Val Lys Gly Arg Asp Trp Thr Phe Leu 
1               5                   10                  15      


Val Tyr Pro Glu Ser Ala Pro Glu Asn Trp Arg Thr Ile Leu Asp Glu 
            20                  25                  30          


Thr Phe Met Arg Trp Val Glu Ser Pro Leu His Asp Lys Asp Val Asn 
        35                  40                  45              


Ala Asp Gly Glu Ile Lys Lys Pro His Trp His Ile Leu Leu Ser Ser 
    50                  55                  60                  


Asp Gly Pro Ile Thr Gln Thr Ala Val Gln Lys Ile Ile Gly Pro Leu 
65                  70                  75                  80  


Asn Cys Pro Asn Ala Gln Lys Val Gly Ser Ala Lys Gly Leu Val Arg 
                85                  90                  95      


Tyr Met Val His Leu Asp Asn Pro Glu Lys Tyr Gln Tyr Ser Leu Asp 
            100                 105                 110         


Glu Ile Val Gly His Asn Gly Ala Asp Val Ala Ser Tyr Phe Glu Leu 
        115                 120                 125             


Thr Ala 
    130 


<210>  7
<211>  98
<212>  PRT
<213>  Fava bean necrotic yellow virus

<400>  7

Met Ala Arg Gln Val Ile Cys Trp Cys Phe Thr Leu Asn Asn Pro Leu 
1               5                   10                  15      


Ser Pro Leu Ser Leu His Asp Ser Met Lys Tyr Leu Val Tyr Gln Thr 
            20                  25                  30          


Glu Gln Gly Glu Ala Gly Asn Ile His Phe Gln Gly Tyr Ile Glu Met 
        35                  40                  45              


Lys Lys Arg Thr Ser Leu Ala Gly Met Lys Lys Leu Ile Pro Gly Ala 
    50                  55                  60                  


His Phe Glu Lys Arg Arg Gly Thr Gln Gly Glu Ala Arg Ala Tyr Ser 
65                  70                  75                  80  


Met Lys Glu Asp Thr Arg Leu Glu Gly Pro Trp Glu Tyr Gly Glu Phe 
                85                  90                  95      


Val Pro 
        


<210>  8
<211>  219
<212>  PRT
<213>  Staphylococcus aureus

<400>  8

Ala Met Tyr His Phe Gln Asn Lys Phe Val Ser Lys Ala Asn Gly Gln 
1               5                   10                  15      


Ser Ala Thr Ala Lys Ser Ala Tyr Asn Ser Ala Ser Arg Ile Lys Asp 
            20                  25                  30          


Phe Lys Glu Asn Glu Phe Lys Asp Tyr Ser Asn Lys Gln Cys Asp Tyr 
        35                  40                  45              


Ser Glu Ile Leu Leu Pro Asn Asn Ala Asp Asp Lys Phe Lys Asp Arg 
    50                  55                  60                  


Glu Tyr Leu Trp Asn Lys Val His Asp Val Glu Asn Arg Lys Asn Ser 
65                  70                  75                  80  


Gln Val Ala Arg Glu Ile Ile Ile Gly Leu Pro Asn Glu Phe Asp Pro 
                85                  90                  95      


Asn Ser Asn Ile Glu Leu Ala Lys Glu Phe Ala Glu Ser Leu Ser Asn 
            100                 105                 110         


Glu Gly Met Ile Val Asp Leu Asn Ile His Lys Ile Asn Glu Glu Asn 
        115                 120                 125             


Pro His Ala His Leu Leu Cys Thr Leu Arg Gly Leu Asp Lys Asn Asn 
    130                 135                 140                 


Glu Phe Glu Pro Lys Arg Lys Gly Asn Asp Tyr Ile Arg Asp Trp Asn 
145                 150                 155                 160 


Thr Lys Glu Lys His Asn Glu Trp Arg Lys Arg Trp Glu Asn Val Gln 
                165                 170                 175     


Asn Lys His Leu Glu Lys Asn Gly Phe Ser Val Arg Val Ser Ala Asp 
            180                 185                 190         


Ser Tyr Lys Asn Gln Asn Ile Asp Leu Glu Pro Thr Lys Lys Glu Gly 
        195                 200                 205             


Trp Lys Ala Arg Lys Phe Glu Asp Glu Thr Gly 
    210                 215                 


<210>  9
<211>  293
<212>  PRT
<213>  Escherichia coli

<400>  9

Met Leu Ser His Met Val Leu Thr Arg Gln Asp Ile Gly Arg Ala Ala 
1               5                   10                  15      


Ser Tyr Tyr Glu Asp Gly Ala Asp Asp Tyr Tyr Ala Lys Asp Gly Asp 
            20                  25                  30          


Ala Ser Glu Trp Gln Gly Lys Gly Ala Glu Glu Leu Gly Leu Ser Gly 
        35                  40                  45              


Glu Val Asp Ser Lys Arg Phe Arg Glu Leu Leu Ala Gly Asn Ile Gly 
    50                  55                  60                  


Glu Gly His Arg Ile Met Arg Ser Ala Thr Arg Gln Asp Ser Lys Glu 
65                  70                  75                  80  


Arg Ile Gly Leu Asp Leu Thr Phe Ser Ala Pro Lys Ser Val Ser Leu 
                85                  90                  95      


Gln Ala Leu Val Ala Gly Asp Ala Glu Ile Ile Lys Ala His Asp Arg 
            100                 105                 110         


Ala Val Ala Arg Thr Leu Glu Gln Ala Glu Ala Arg Ala Gln Ala Arg 
        115                 120                 125             


Gln Lys Ile Gln Gly Lys Thr Arg Ile Glu Thr Thr Gly Asn Leu Val 
    130                 135                 140                 


Ile Gly Lys Phe Arg His Glu Thr Ser Arg Glu Arg Asp Pro Gln Leu 
145                 150                 155                 160 


His Thr His Ala Val Ile Leu Asn Met Thr Lys Arg Ser Asp Gly Gln 
                165                 170                 175     


Trp Arg Ala Leu Lys Asn Asp Glu Ile Val Lys Ala Thr Arg Tyr Leu 
            180                 185                 190         


Gly Ala Val Tyr Asn Ala Glu Leu Ala His Glu Leu Gln Lys Leu Gly 
        195                 200                 205             


Tyr Gln Leu Arg Tyr Gly Lys Asp Gly Asn Phe Asp Leu Ala His Ile 
    210                 215                 220                 


Asp Arg Gln Gln Ile Glu Gly Phe Ser Lys Arg Thr Glu Gln Ile Ala 
225                 230                 235                 240 


Glu Trp Tyr Ala Ala Arg Gly Leu Asp Pro Asn Ser Val Ser Leu Glu 
                245                 250                 255     


Gln Lys Gln Ala Ala Lys Val Leu Ser Arg Ala Lys Lys Thr Ser Val 
            260                 265                 270         


Asp Arg Glu Ala Leu Arg Ala Glu Trp Gln Ala Thr Ala Lys Glu Leu 
        275                 280                 285             


Gly Ile Asp Phe Ser 
    290             


<210>  10
<211>  257
<212>  PRT
<213>  Agrobacterium tumefaciens

<400>  10

Met Pro Asp Arg Ala Gln Val Ile Ile Arg Ile Val Pro Gly Gly Gly 
1               5                   10                  15      


Thr Lys Thr Leu Gln Gln Ile Ile Asn Gln Leu Glu Tyr Leu Ser Arg 
            20                  25                  30          


Lys Gly Arg Leu Glu Leu Gln Arg Ser Ala Arg His Leu Asp Ile Pro 
        35                  40                  45              


Leu Pro Pro Asp Gln Ile His Glu Leu Ala Arg Ser Trp Val Gln Glu 
    50                  55                  60                  


Thr Gly Thr Tyr Asp Glu Ser Gln Pro Asp Glu Glu Arg Gln Gln Glu 
65                  70                  75                  80  


Leu Thr Thr His Ile Ile Val Ser Phe Pro Ala Gly Thr Ser Gln Val 
                85                  90                  95      


Ala Ala Tyr Ala Ala Ser Arg Glu Trp Ala Ala Glu Met Phe Gly Ser 
            100                 105                 110         


Gly Ala Gly Gly Gly Arg Tyr Asn Tyr Leu Thr Ala Phe His Ile Asp 
        115                 120                 125             


Arg Asp His Pro His Leu His Val Val Val Asn Arg Arg Glu Leu Leu 
    130                 135                 140                 


Gly His Gly Trp Leu Lys Ile Ser Arg Arg His Pro Gln Leu Asn Tyr 
145                 150                 155                 160 


Asp Ala Leu Arg Ile Lys Met Ala Glu Ile Ser Leu Arg His Gly Ile 
                165                 170                 175     


Ala Leu Asp Ala Ser Arg Arg Ala Glu Arg Gly Ile Thr Glu Arg Pro 
            180                 185                 190         


Ile Thr Tyr Ala Gln Tyr Arg Arg Leu Glu Arg Glu Gln Ala Arg Gln 
        195                 200                 205             


Ile Arg Phe Glu Asp Ala Asp Leu Glu Gln Ser Ser Pro Gln Gly Asp 
    210                 215                 220                 


His Pro Glu Phe Ser Gln Pro Phe Asp Thr Ser Pro Phe Glu Ala Ser 
225                 230                 235                 240 


Ala Gly Gly Pro Glu Asp Met Pro Arg Pro Asn Asn Arg Gln Asn Glu 
                245                 250                 255     


Ser 
    


<210>  11
<211>  120
<212>  PRT
<213>  Tomato yellow leaf curl virus

<400>  11

Met Pro Arg Leu Phe Lys Ile Tyr Ala Lys Asn Tyr Phe Leu Thr Tyr 
1               5                   10                  15      


Pro Asn Cys Ser Leu Ser Lys Glu Glu Ala Leu Ser Gln Leu Lys Lys 
            20                  25                  30          


Leu Glu Thr Pro Thr Asn Lys Lys Tyr Ile Lys Val Cys Lys Glu Leu 
        35                  40                  45              


His Glu Asn Gly Glu Pro His Leu His Val Leu Ile Gln Phe Glu Gly 
    50                  55                  60                  


Lys Tyr Gln Cys Lys Asn Gln Arg Phe Phe Asp Leu Val Ser Pro Asn 
65                  70                  75                  80  


Arg Ser Ala His Phe His Pro Asn Ile Gln Ala Ala Lys Ser Ser Thr 
                85                  90                  95      


Asp Val Lys Thr Tyr Val Glu Lys Asp Gly Asn Phe Ile Asp Phe Gly 
            100                 105                 110         


Val Ser Gln Ile Asp Gly Arg Ser 
        115                 120 


<210>  12
<211>  130
<212>  PRT
<213>  Streptococcus pneumoniae

<400>  12

Met Ser Glu Lys Lys Glu Ile Val Lys Gly Arg Asp Trp Thr Phe Leu 
1               5                   10                  15      


Val Tyr Pro Glu Ser Ala Pro Glu Asn Trp Arg Thr Ile Leu Asp Glu 
            20                  25                  30          


Thr Phe Met Arg Trp Val Glu Ser Pro Leu His Asp Lys Asp Val Asn 
        35                  40                  45              


Ala Asp Gly Glu Ile Lys Lys Pro His Trp His Ile Leu Leu Ser Ser 
    50                  55                  60                  


Asp Gly Pro Ile Thr Gln Thr Ala Val Gln Lys Ile Ile Gly Pro Leu 
65                  70                  75                  80  


Asn Cys Pro Asn Ala Gln Lys Val Gly Ser Ala Lys Gly Leu Val Arg 
                85                  90                  95      


Tyr Met Val His Leu Asp Asn Pro Glu Lys Tyr Gln Tyr Ser Leu Asp 
            100                 105                 110         


Glu Ile Val Gly His Asn Gly Ala Asp Val Ala Ser Tyr Phe Glu Leu 
        115                 120                 125             


Thr Ala 
    130 


<210>  13
<211>  111
<212>  PRT
<213>  Duck circovirus

<400>  13

Met Ala Lys Ser Gly Asn Tyr Ser Tyr Lys Arg Trp Val Phe Thr Ile 
1               5                   10                  15      


Asn Asn Pro Thr Phe Glu Asp Tyr Val His Val Leu Glu Phe Cys Thr 
            20                  25                  30          


Leu Asp Asn Cys Lys Phe Ala Ile Val Gly Glu Glu Lys Gly Ala Asn 
        35                  40                  45              


Gly Thr Pro His Leu Gln Gly Phe Leu Asn Leu Arg Ser Asn Ala Arg 
    50                  55                  60                  


Ala Ala Ala Leu Glu Glu Ser Leu Gly Gly Arg Ala Trp Leu Ser Arg 
65                  70                  75                  80  


Ala Arg Gly Ser Asp Glu Asp Asn Glu Glu Tyr Cys Ala Lys Glu Ser 
                85                  90                  95      


Thr Tyr Leu Arg Val Gly Glu Pro Val Ser Lys Gly Arg Ser Ser 
            100                 105                 110     


<210>  14
<211>  1388
<212>  PRT
<213>  Streptococcus thermophilus

<400>  14

Met Thr Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Thr Thr Asp Asn Tyr Lys Val Pro Ser Lys Lys Met 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Ser Lys Lys Tyr Ile Lys Lys Asn Leu Leu 
        35                  40                  45              


Gly Val Leu Leu Phe Asp Ser Gly Ile Thr Ala Glu Gly Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Thr Glu Met Ala Thr Leu Asp Asp Ala 
                85                  90                  95      


Phe Phe Gln Arg Leu Asp Asp Ser Phe Leu Val Pro Asp Asp Lys Arg 
            100                 105                 110         


Asp Ser Lys Tyr Pro Ile Phe Gly Asn Leu Val Glu Glu Lys Ala Tyr 
        115                 120                 125             


His Asp Glu Phe Pro Thr Ile Tyr His Leu Arg Lys Tyr Leu Ala Asp 
    130                 135                 140                 


Ser Thr Lys Lys Ala Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Tyr Arg Gly His Phe Leu Ile Glu Gly Glu Phe Asn Ser 
                165                 170                 175     


Lys Asn Asn Asp Ile Gln Lys Asn Phe Gln Asp Phe Leu Asp Thr Tyr 
            180                 185                 190         


Asn Ala Ile Phe Glu Ser Asp Leu Ser Leu Glu Asn Ser Lys Gln Leu 
        195                 200                 205             


Glu Glu Ile Val Lys Asp Lys Ile Ser Lys Leu Glu Lys Lys Asp Arg 
    210                 215                 220                 


Ile Leu Lys Leu Phe Pro Gly Glu Lys Asn Ser Gly Ile Phe Ser Glu 
225                 230                 235                 240 


Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Arg Lys Cys Phe 
                245                 250                 255     


Asn Leu Asp Glu Lys Ala Ser Leu His Phe Ser Lys Glu Ser Tyr Asp 
            260                 265                 270         


Glu Asp Leu Glu Thr Leu Leu Gly Tyr Ile Gly Asp Asp Tyr Ser Asp 
        275                 280                 285             


Val Phe Leu Lys Ala Lys Lys Leu Tyr Asp Ala Ile Leu Leu Ser Gly 
    290                 295                 300                 


Phe Leu Thr Val Thr Asp Asn Glu Thr Glu Ala Pro Leu Ser Ser Ala 
305                 310                 315                 320 


Met Ile Lys Arg Tyr Asn Glu His Lys Glu Asp Leu Ala Leu Leu Lys 
                325                 330                 335     


Glu Tyr Ile Arg Asn Ile Ser Leu Lys Thr Tyr Asn Glu Val Phe Lys 
            340                 345                 350         


Asp Asp Thr Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Thr Asn 
        355                 360                 365             


Gln Glu Asp Phe Tyr Val Tyr Leu Lys Lys Leu Leu Ala Glu Phe Glu 
    370                 375                 380                 


Gly Ala Asp Tyr Phe Leu Glu Lys Ile Asp Arg Glu Asp Phe Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro Tyr Gln Ile His Leu 
                405                 410                 415     


Gln Glu Met Arg Ala Ile Leu Asp Lys Gln Ala Lys Phe Tyr Pro Phe 
            420                 425                 430         


Leu Ala Lys Asn Lys Glu Arg Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Asp Phe Ala Trp 
    450                 455                 460                 


Ser Ile Arg Lys Arg Asn Glu Lys Ile Thr Pro Trp Asn Phe Glu Asp 
465                 470                 475                 480 


Val Ile Asp Lys Glu Ser Ser Ala Glu Ala Phe Ile Asn Arg Met Thr 
                485                 490                 495     


Ser Phe Asp Leu Tyr Leu Pro Glu Glu Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Thr Phe Asn Val Tyr Asn Glu Leu Thr Lys Val Arg 
        515                 520                 525             


Phe Ile Ala Glu Ser Met Arg Asp Tyr Gln Phe Leu Asp Ser Lys Gln 
    530                 535                 540                 


Lys Lys Asp Ile Val Arg Leu Tyr Phe Lys Asp Lys Arg Lys Val Thr 
545                 550                 555                 560 


Asp Lys Asp Ile Ile Glu Tyr Leu His Ala Ile Tyr Gly Tyr Asp Gly 
                565                 570                 575     


Ile Glu Leu Lys Gly Ile Glu Lys Gln Phe Asn Ser Ser Leu Ser Thr 
            580                 585                 590         


Tyr His Asp Leu Leu Asn Ile Ile Asn Asp Lys Glu Phe Leu Asp Asp 
        595                 600                 605             


Ser Ser Asn Glu Ala Ile Ile Glu Glu Ile Ile His Thr Leu Thr Ile 
    610                 615                 620                 


Phe Glu Asp Arg Glu Met Ile Lys Gln Arg Leu Ser Lys Phe Glu Asn 
625                 630                 635                 640 


Ile Phe Asp Lys Ser Val Leu Lys Lys Leu Ser Arg Arg His Tyr Thr 
                645                 650                 655     


Gly Trp Gly Lys Leu Ser Ala Lys Leu Ile Asn Gly Ile Arg Asp Glu 
            660                 665                 670         


Lys Ser Gly Asn Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly Ile Ser 
        675                 680                 685             


Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ala Leu Ser Phe Lys 
    690                 695                 700                 


Lys Lys Ile Gln Lys Ala Gln Ile Ile Gly Asp Glu Asp Lys Gly Asn 
705                 710                 715                 720 


Ile Lys Glu Val Val Lys Ser Leu Pro Gly Ser Pro Ala Ile Lys Lys 
                725                 730                 735     


Gly Ile Leu Gln Ser Ile Lys Ile Val Asp Glu Leu Val Lys Val Met 
            740                 745                 750         


Gly Gly Arg Lys Pro Glu Ser Ile Val Val Glu Met Ala Arg Glu Asn 
        755                 760                 765             


Gln Tyr Thr Asn Gln Gly Lys Ser Asn Ser Gln Gln Arg Leu Lys Arg 
    770                 775                 780                 


Leu Glu Lys Ser Leu Lys Glu Leu Gly Ser Lys Ile Leu Lys Glu Asn 
785                 790                 795                 800 


Ile Pro Ala Lys Leu Ser Lys Ile Asp Asn Asn Ala Leu Gln Asn Asp 
                805                 810                 815     


Arg Leu Tyr Leu Tyr Tyr Leu Gln Asn Gly Lys Asp Met Tyr Thr Gly 
            820                 825                 830         


Asp Asp Leu Asp Ile Asp Arg Leu Ser Asn Tyr Asp Ile Asp His Ile 
        835                 840                 845             


Ile Pro Gln Ala Phe Leu Lys Asp Asn Ser Ile Asp Asn Lys Val Leu 
    850                 855                 860                 


Val Ser Ser Ala Ser Asn Arg Gly Lys Ser Asp Asp Val Pro Ser Leu 
865                 870                 875                 880 


Glu Val Val Lys Lys Arg Lys Thr Phe Trp Tyr Gln Leu Leu Lys Ser 
                885                 890                 895     


Lys Leu Ile Ser Gln Arg Lys Phe Asp Asn Leu Thr Lys Ala Glu Arg 
            900                 905                 910         


Gly Gly Leu Ser Pro Glu Asp Lys Ala Gly Phe Ile Gln Arg Gln Leu 
        915                 920                 925             


Val Glu Thr Arg Gln Ile Thr Lys His Val Ala Arg Leu Leu Asp Glu 
    930                 935                 940                 


Lys Phe Asn Asn Lys Lys Asp Glu Asn Asn Arg Ala Val Arg Thr Val 
945                 950                 955                 960 


Lys Ile Ile Thr Leu Lys Ser Thr Leu Val Ser Gln Phe Arg Lys Asp 
                965                 970                 975     


Phe Glu Leu Tyr Lys Val Arg Glu Ile Asn Asp Phe His His Ala His 
            980                 985                 990         


Asp Ala Tyr Leu Asn Ala Val Val  Ala Ser Ala Leu Leu  Lys Lys Tyr 
        995                 1000                 1005             


Pro Lys  Leu Glu Pro Glu Phe  Val Tyr Gly Asp Tyr  Pro Lys Tyr 
    1010                 1015                 1020             


Asn Ser  Phe Arg Glu Arg Lys  Ser Ala Thr Glu Lys  Val Tyr Phe 
    1025                 1030                 1035             


Tyr Ser  Asn Ile Met Asn Ile  Phe Lys Lys Ser Ile  Ser Leu Ala 
    1040                 1045                 1050             


Asp Gly  Arg Val Ile Glu Arg  Pro Leu Ile Glu Val  Asn Glu Glu 
    1055                 1060                 1065             


Thr Gly  Glu Ser Val Trp Asn  Lys Glu Ser Asp Leu  Ala Thr Val 
    1070                 1075                 1080             


Arg Arg  Val Leu Ser Tyr Pro  Gln Val Asn Val Val  Lys Lys Val 
    1085                 1090                 1095             


Glu Glu  Gln Asn His Gly Leu  Asp Arg Gly Lys Pro  Lys Gly Leu 
    1100                 1105                 1110             


Phe Asn  Ala Asn Leu Ser Ser  Lys Pro Lys Pro Asn  Ser Asn Glu 
    1115                 1120                 1125             


Asn Leu  Val Gly Ala Lys Glu  Tyr Leu Asp Pro Lys  Lys Tyr Gly 
    1130                 1135                 1140             


Gly Tyr  Ala Gly Ile Ser Asn  Ser Phe Thr Val Leu  Val Lys Gly 
    1145                 1150                 1155             


Thr Ile  Glu Lys Gly Ala Lys  Lys Lys Ile Thr Asn  Val Leu Glu 
    1160                 1165                 1170             


Phe Gln  Gly Ile Ser Ile Leu  Asp Arg Ile Asn Tyr  Arg Lys Asp 
    1175                 1180                 1185             


Lys Leu  Asn Phe Leu Leu Glu  Lys Gly Tyr Lys Asp  Ile Glu Leu 
    1190                 1195                 1200             


Ile Ile  Glu Leu Pro Lys Tyr  Ser Leu Phe Glu Leu  Ser Asp Gly 
    1205                 1210                 1215             


Ser Arg  Arg Met Leu Ala Ser  Ile Leu Ser Thr Asn  Asn Lys Arg 
    1220                 1225                 1230             


Gly Glu  Ile His Lys Gly Asn  Gln Ile Phe Leu Ser  Gln Lys Phe 
    1235                 1240                 1245             


Val Lys  Leu Leu Tyr His Ala  Lys Arg Ile Ser Asn  Thr Ile Asn 
    1250                 1255                 1260             


Glu Asn  His Arg Lys Tyr Val  Glu Asn His Lys Lys  Glu Phe Glu 
    1265                 1270                 1275             


Glu Leu  Phe Tyr Tyr Ile Leu  Glu Phe Asn Glu Asn  Tyr Val Gly 
    1280                 1285                 1290             


Ala Lys  Lys Asn Gly Lys Leu  Leu Asn Ser Ala Phe  Gln Ser Trp 
    1295                 1300                 1305             


Gln Asn  His Ser Ile Asp Glu  Leu Cys Ser Ser Phe  Ile Gly Pro 
    1310                 1315                 1320             


Thr Gly  Ser Glu Arg Lys Gly  Leu Phe Glu Leu Thr  Ser Arg Gly 
    1325                 1330                 1335             


Ser Ala  Ala Asp Phe Glu Phe  Leu Gly Val Lys Ile  Pro Arg Tyr 
    1340                 1345                 1350             


Arg Asp  Tyr Thr Pro Ser Ser  Leu Leu Lys Asp Ala  Thr Leu Ile 
    1355                 1360                 1365             


His Gln  Ser Val Thr Gly Leu  Tyr Glu Thr Arg Ile  Asp Leu Ala 
    1370                 1375                 1380             


Lys Leu  Gly Glu Gly 
    1385             


<210>  15
<211>  1368
<212>  PRT
<213>  Streptococcus pyogenes

<400>  15

Met Asp Lys Lys Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys 
            100                 105                 110         


His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr 
        115                 120                 125             


His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp 
    130                 135                 140                 


Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro 
                165                 170                 175     


Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr 
            180                 185                 190         


Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala 
        195                 200                 205             


Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn 
    210                 215                 220                 


Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn 
225                 230                 235                 240 


Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe 
                245                 250                 255     


Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp 
            260                 265                 270         


Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp 
        275                 280                 285             


Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp 
    290                 295                 300                 


Ile Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys 
                325                 330                 335     


Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe 
            340                 345                 350         


Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser 
        355                 360                 365             


Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp 
    370                 375                 380                 


Gly Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe 
            420                 425                 430         


Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp 
    450                 455                 460                 


Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu 
465                 470                 475                 480 


Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr 
                485                 490                 495     


Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln 
    530                 535                 540                 


Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr 
545                 550                 555                 560 


Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp 
                565                 570                 575     


Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly 
            580                 585                 590         


Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp 
        595                 600                 605             


Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr 
    610                 615                 620                 


Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala 
625                 630                 635                 640 


His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg Arg Tyr 
                645                 650                 655     


Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp 
            660                 665                 670         


Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe 
        675                 680                 685             


Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ser Leu Thr Phe 
    690                 695                 700                 


Lys Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln Gly Asp Ser Leu 
705                 710                 715                 720 


His Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly 
                725                 730                 735     


Ile Leu Gln Thr Val Lys Val Val Asp Glu Leu Val Lys Val Met Gly 
            740                 745                 750         


Arg His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Thr Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met Lys Arg Ile 
    770                 775                 780                 


Glu Glu Gly Ile Lys Glu Leu Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu Asp Ile Asn Arg 
            820                 825                 830         


Leu Ser Asp Tyr Asp Val Asp His Ile Val Pro Gln Ser Phe Leu Lys 
        835                 840                 845             


Asp Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asn Val Pro Ser Glu Glu Val Val Lys Lys Met Lys 
865                 870                 875                 880 


Asn Tyr Trp Arg Gln Leu Leu Asn Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu Leu Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Gln Ile Leu Asp Ser Arg Met Asn Thr Lys Tyr Asp 
    930                 935                 940                 


Glu Asn Asp Lys Leu Ile Arg Glu Val Lys Val Ile Thr Leu Lys Ser 
945                 950                 955                 960 


Lys Leu Val Ser Asp Phe Arg Lys Asp Phe Gln Phe Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asn Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Val Gly Thr Ala Leu Ile Lys Lys  Tyr Pro Lys Leu Glu  Ser Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Lys Val  Tyr Asp Val Arg Lys  Met Ile Ala 
    1010                 1015                 1020             


Lys Ser  Glu Gln Glu Ile Gly  Lys Ala Thr Ala Lys  Tyr Phe Phe 
    1025                 1030                 1035             


Tyr Ser  Asn Ile Met Asn Phe  Phe Lys Thr Glu Ile  Thr Leu Ala 
    1040                 1045                 1050             


Asn Gly  Glu Ile Arg Lys Arg  Pro Leu Ile Glu Thr  Asn Gly Glu 
    1055                 1060                 1065             


Thr Gly  Glu Ile Val Trp Asp  Lys Gly Arg Asp Phe  Ala Thr Val 
    1070                 1075                 1080             


Arg Lys  Val Leu Ser Met Pro  Gln Val Asn Ile Val  Lys Lys Thr 
    1085                 1090                 1095             


Glu Val  Gln Thr Gly Gly Phe  Ser Lys Glu Ser Ile  Leu Pro Lys 
    1100                 1105                 1110             


Arg Asn  Ser Asp Lys Leu Ile  Ala Arg Lys Lys Asp  Trp Asp Pro 
    1115                 1120                 1125             


Lys Lys  Tyr Gly Gly Phe Asp  Ser Pro Thr Val Ala  Tyr Ser Val 
    1130                 1135                 1140             


Leu Val  Val Ala Lys Val Glu  Lys Gly Lys Ser Lys  Lys Leu Lys 
    1145                 1150                 1155             


Ser Val  Lys Glu Leu Leu Gly  Ile Thr Ile Met Glu  Arg Ser Ser 
    1160                 1165                 1170             


Phe Glu  Lys Asn Pro Ile Asp  Phe Leu Glu Ala Lys  Gly Tyr Lys 
    1175                 1180                 1185             


Glu Val  Lys Lys Asp Leu Ile  Ile Lys Leu Pro Lys  Tyr Ser Leu 
    1190                 1195                 1200             


Phe Glu  Leu Glu Asn Gly Arg  Lys Arg Met Leu Ala  Ser Ala Gly 
    1205                 1210                 1215             


Glu Leu  Gln Lys Gly Asn Glu  Leu Ala Leu Pro Ser  Lys Tyr Val 
    1220                 1225                 1230             


Asn Phe  Leu Tyr Leu Ala Ser  His Tyr Glu Lys Leu  Lys Gly Ser 
    1235                 1240                 1245             


Pro Glu  Asp Asn Glu Gln Lys  Gln Leu Phe Val Glu  Gln His Lys 
    1250                 1255                 1260             


His Tyr  Leu Asp Glu Ile Ile  Glu Gln Ile Ser Glu  Phe Ser Lys 
    1265                 1270                 1275             


Arg Val  Ile Leu Ala Asp Ala  Asn Leu Asp Lys Val  Leu Ser Ala 
    1280                 1285                 1290             


Tyr Asn  Lys His Arg Asp Lys  Pro Ile Arg Glu Gln  Ala Glu Asn 
    1295                 1300                 1305             


Ile Ile  His Leu Phe Thr Leu  Thr Asn Leu Gly Ala  Pro Ala Ala 
    1310                 1315                 1320             


Phe Lys  Tyr Phe Asp Thr Thr  Ile Asp Arg Lys Arg  Tyr Thr Ser 
    1325                 1330                 1335             


Thr Lys  Glu Val Leu Asp Ala  Thr Leu Ile His Gln  Ser Ile Thr 
    1340                 1345                 1350             


Gly Leu  Tyr Glu Thr Arg Ile  Asp Leu Ser Gln Leu  Gly Gly Asp 
    1355                 1360                 1365             


<210>  16
<211>  1616
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  16

Met Arg Gly Ser His His His His His His Met Ala Ser Gly Ser Asp 
1               5                   10                  15      


Ser Glu Val Asn Gln Glu Ala Lys Pro Glu Val Lys Pro Glu Val Lys 
            20                  25                  30          


Pro Glu Thr His Ile Asn Leu Lys Val Ser Asp Gly Ser Ser Glu Ile 
        35                  40                  45              


Phe Phe Lys Ile Lys Lys Thr Thr Pro Leu Arg Arg Leu Met Glu Ala 
    50                  55                  60                  


Phe Ala Lys Arg Gln Gly Lys Glu Met Asp Ser Leu Arg Phe Leu Tyr 
65                  70                  75                  80  


Asp Gly Ile Arg Ile Gln Ala Asp Gln Thr Pro Glu Asp Leu Asp Met 
                85                  90                  95      


Glu Asp Asn Asp Ile Ile Glu Ala His Arg Glu Gln Ile Gly Gly Ser 
            100                 105                 110         


Met Asp Lys Lys Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
        115                 120                 125             


Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe 
    130                 135                 140                 


Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile 
145                 150                 155                 160 


Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu 
                165                 170                 175     


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys 
            180                 185                 190         


Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser 
        195                 200                 205             


Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys 
    210                 215                 220                 


His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr 
225                 230                 235                 240 


His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp 
                245                 250                 255     


Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
            260                 265                 270         


Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro 
        275                 280                 285             


Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr 
    290                 295                 300                 


Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala 
305                 310                 315                 320 


Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn 
                325                 330                 335     


Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn 
            340                 345                 350         


Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe 
        355                 360                 365             


Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp 
    370                 375                 380                 


Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp 
385                 390                 395                 400 


Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp 
                405                 410                 415     


Ile Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser 
            420                 425                 430         


Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys 
        435                 440                 445             


Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe 
    450                 455                 460                 


Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser 
465                 470                 475                 480 


Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp 
                485                 490                 495     


Gly Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg 
            500                 505                 510         


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
        515                 520                 525             


Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe 
    530                 535                 540                 


Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 
545                 550                 555                 560 


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp 
                565                 570                 575     


Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu 
            580                 585                 590         


Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr 
        595                 600                 605             


Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser 
    610                 615                 620                 


Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
625                 630                 635                 640 


Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln 
                645                 650                 655     


Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr 
            660                 665                 670         


Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp 
        675                 680                 685             


Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly 
    690                 695                 700                 


Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp 
705                 710                 715                 720 


Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr 
                725                 730                 735     


Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala 
            740                 745                 750         


His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg Arg Tyr 
        755                 760                 765             


Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp 
    770                 775                 780                 


Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe 
785                 790                 795                 800 


Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ser Leu Thr Phe 
                805                 810                 815     


Lys Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln Gly Asp Ser Leu 
            820                 825                 830         


His Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly 
        835                 840                 845             


Ile Leu Gln Thr Val Lys Val Val Asp Glu Leu Val Lys Val Met Gly 
    850                 855                 860                 


Arg His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln 
865                 870                 875                 880 


Thr Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met Lys Arg Ile 
                885                 890                 895     


Glu Glu Gly Ile Lys Glu Leu Gly Ser Gln Ile Leu Lys Glu His Pro 
            900                 905                 910         


Val Glu Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu 
        915                 920                 925             


Gln Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu Asp Ile Asn Arg 
    930                 935                 940                 


Leu Ser Asp Tyr Asp Val Asp His Ile Val Pro Gln Ser Phe Leu Lys 
945                 950                 955                 960 


Asp Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys Asn Arg 
                965                 970                 975     


Gly Lys Ser Asp Asn Val Pro Ser Glu Glu Val Val Lys Lys Met Lys 
            980                 985                 990         


Asn Tyr Trp Arg Gln Leu Leu Asn  Ala Lys Leu Ile Thr  Gln Arg Lys 
        995                 1000                 1005             


Phe Asp  Asn Leu Thr Lys Ala  Glu Arg Gly Gly Leu  Ser Glu Leu 
    1010                 1015                 1020             


Asp Lys  Ala Gly Phe Ile Lys  Arg Gln Leu Val Glu  Thr Arg Gln 
    1025                 1030                 1035             


Ile Thr  Lys His Val Ala Gln  Ile Leu Asp Ser Arg  Met Asn Thr 
    1040                 1045                 1050             


Lys Tyr  Asp Glu Asn Asp Lys  Leu Ile Arg Glu Val  Lys Val Ile 
    1055                 1060                 1065             


Thr Leu  Lys Ser Lys Leu Val  Ser Asp Phe Arg Lys  Asp Phe Gln 
    1070                 1075                 1080             


Phe Tyr  Lys Val Arg Glu Ile  Asn Asn Tyr His His  Ala His Asp 
    1085                 1090                 1095             


Ala Tyr  Leu Asn Ala Val Val  Gly Thr Ala Leu Ile  Lys Lys Tyr 
    1100                 1105                 1110             


Pro Lys  Leu Glu Ser Glu Phe  Val Tyr Gly Asp Tyr  Lys Val Tyr 
    1115                 1120                 1125             


Asp Val  Arg Lys Met Ile Ala  Lys Ser Glu Gln Glu  Ile Gly Lys 
    1130                 1135                 1140             


Ala Thr  Ala Lys Tyr Phe Phe  Tyr Ser Asn Ile Met  Asn Phe Phe 
    1145                 1150                 1155             


Lys Thr  Glu Ile Thr Leu Ala  Asn Gly Glu Ile Arg  Lys Arg Pro 
    1160                 1165                 1170             


Leu Ile  Glu Thr Asn Gly Glu  Thr Gly Glu Ile Val  Trp Asp Lys 
    1175                 1180                 1185             


Gly Arg  Asp Phe Ala Thr Val  Arg Lys Val Leu Ser  Met Pro Gln 
    1190                 1195                 1200             


Val Asn  Ile Val Lys Lys Thr  Glu Val Gln Thr Gly  Gly Phe Ser 
    1205                 1210                 1215             


Lys Glu  Ser Ile Leu Pro Lys  Arg Asn Ser Asp Lys  Leu Ile Ala 
    1220                 1225                 1230             


Arg Lys  Lys Asp Trp Asp Pro  Lys Lys Tyr Gly Gly  Phe Asp Ser 
    1235                 1240                 1245             


Pro Thr  Val Ala Tyr Ser Val  Leu Val Val Ala Lys  Val Glu Lys 
    1250                 1255                 1260             


Gly Lys  Ser Lys Lys Leu Lys  Ser Val Lys Glu Leu  Leu Gly Ile 
    1265                 1270                 1275             


Thr Ile  Met Glu Arg Ser Ser  Phe Glu Lys Asn Pro  Ile Asp Phe 
    1280                 1285                 1290             


Leu Glu  Ala Lys Gly Tyr Lys  Glu Val Lys Lys Asp  Leu Ile Ile 
    1295                 1300                 1305             


Lys Leu  Pro Lys Tyr Ser Leu  Phe Glu Leu Glu Asn  Gly Arg Lys 
    1310                 1315                 1320             


Arg Met  Leu Ala Ser Ala Gly  Glu Leu Gln Lys Gly  Asn Glu Leu 
    1325                 1330                 1335             


Ala Leu  Pro Ser Lys Tyr Val  Asn Phe Leu Tyr Leu  Ala Ser His 
    1340                 1345                 1350             


Tyr Glu  Lys Leu Lys Gly Ser  Pro Glu Asp Asn Glu  Gln Lys Gln 
    1355                 1360                 1365             


Leu Phe  Val Glu Gln His Lys  His Tyr Leu Asp Glu  Ile Ile Glu 
    1370                 1375                 1380             


Gln Ile  Ser Glu Phe Ser Lys  Arg Val Ile Leu Ala  Asp Ala Asn 
    1385                 1390                 1395             


Leu Asp  Lys Val Leu Ser Ala  Tyr Asn Lys His Arg  Asp Lys Pro 
    1400                 1405                 1410             


Ile Arg  Glu Gln Ala Glu Asn  Ile Ile His Leu Phe  Thr Leu Thr 
    1415                 1420                 1425             


Asn Leu  Gly Ala Pro Ala Ala  Phe Lys Tyr Phe Asp  Thr Thr Ile 
    1430                 1435                 1440             


Asp Arg  Lys Arg Tyr Thr Ser  Thr Lys Glu Val Leu  Asp Ala Thr 
    1445                 1450                 1455             


Leu Ile  His Gln Ser Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp 
    1460                 1465                 1470             


Leu Ser  Gln Leu Gly Gly Asp  Gly Gly Gly Ser Gly  Thr Arg Leu 
    1475                 1480                 1485             


Pro Lys  Lys Lys Arg Lys Val  Gly Gly Gly Ser Gly  Ser Pro Ser 
    1490                 1495                 1500             


Lys Lys  Asn Gly Arg Ser Gly  Pro Gln Pro His Lys  Arg Trp Val 
    1505                 1510                 1515             


Phe Thr  Leu Asn Asn Pro Ser  Glu Asp Glu Arg Lys  Lys Ile Arg 
    1520                 1525                 1530             


Asp Leu  Pro Ile Ser Leu Phe  Asp Tyr Phe Ile Val  Gly Glu Glu 
    1535                 1540                 1545             


Gly Asn  Glu Glu Gly Arg Thr  Pro His Leu Gln Gly  Phe Ala Asn 
    1550                 1555                 1560             


Phe Val  Lys Lys Gln Thr Phe  Asn Lys Val Lys Trp  Tyr Leu Gly 
    1565                 1570                 1575             


Ala Arg  Cys His Ile Glu Lys  Ala Lys Gly Thr Asp  Gln Gln Asn 
    1580                 1585                 1590             


Lys Glu  Tyr Cys Ser Lys Glu  Gly Asn Leu Leu Met  Glu Cys Gly 
    1595                 1600                 1605             


Ala Pro  Arg Ser Gln Gly Gln  Arg 
    1610                 1615     


<210>  17
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide

<400>  17
ctcccacctt tctcatccaa g                                                 21


<210>  18
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide

<400>  18
acatcacccc tctacctcc                                                    19


<210>  19
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide

<400>  19
gagactggct cttaaaaagt gc                                                22


<210>  20
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide

<400>  20
gctaatcttc ttgaacagcc g                                                 21


<210>  21
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide

<400>  21
ctgacaactc ttttcatctt ct                                                22


<210>  22
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide

<400>  22
aaagtgcagg gtctggcg                                                     18


<210>  23
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide

<400>  23
atgagcttgc tcctcccaaa cc                                                22


<210>  24
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide

<400>  24
tcactactta ccttgctgga cc                                                22


