                         SEQUENCE LISTING

<110>  Epizyme, Inc.
 
<120>  Inhibitors of EZH2 and Methods of Use Thereof

<130>  EPIZ-083/001WO

<150>  62/519,078
<151>  2017-06-13

<160>  26    

<170>  PatentIn version 3.5

<210>  1
<211>  746
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Gly Gln Thr Gly Lys Lys Ser Glu Lys Gly Pro Val Cys Trp Arg 
1               5                   10                  15      


Lys Arg Val Lys Ser Glu Tyr Met Arg Leu Arg Gln Leu Lys Arg Phe 
            20                  25                  30          


Arg Arg Ala Asp Glu Val Lys Ser Met Phe Ser Ser Asn Arg Gln Lys 
        35                  40                  45              


Ile Leu Glu Arg Thr Glu Ile Leu Asn Gln Glu Trp Lys Gln Arg Arg 
    50                  55                  60                  


Ile Gln Pro Val His Ile Leu Thr Ser Val Ser Ser Leu Arg Gly Thr 
65                  70                  75                  80  


Arg Glu Cys Ser Val Thr Ser Asp Leu Asp Phe Pro Thr Gln Val Ile 
                85                  90                  95      


Pro Leu Lys Thr Leu Asn Ala Val Ala Ser Val Pro Ile Met Tyr Ser 
            100                 105                 110         


Trp Ser Pro Leu Gln Gln Asn Phe Met Val Glu Asp Glu Thr Val Leu 
        115                 120                 125             


His Asn Ile Pro Tyr Met Gly Asp Glu Val Leu Asp Gln Asp Gly Thr 
    130                 135                 140                 


Phe Ile Glu Glu Leu Ile Lys Asn Tyr Asp Gly Lys Val His Gly Asp 
145                 150                 155                 160 


Arg Glu Cys Gly Phe Ile Asn Asp Glu Ile Phe Val Glu Leu Val Asn 
                165                 170                 175     


Ala Leu Gly Gln Tyr Asn Asp Asp Asp Asp Asp Asp Asp Gly Asp Asp 
            180                 185                 190         


Pro Glu Glu Arg Glu Glu Lys Gln Lys Asp Leu Glu Asp His Arg Asp 
        195                 200                 205             


Asp Lys Glu Ser Arg Pro Pro Arg Lys Phe Pro Ser Asp Lys Ile Phe 
    210                 215                 220                 


Glu Ala Ile Ser Ser Met Phe Pro Asp Lys Gly Thr Ala Glu Glu Leu 
225                 230                 235                 240 


Lys Glu Lys Tyr Lys Glu Leu Thr Glu Gln Gln Leu Pro Gly Ala Leu 
                245                 250                 255     


Pro Pro Glu Cys Thr Pro Asn Ile Asp Gly Pro Asn Ala Lys Ser Val 
            260                 265                 270         


Gln Arg Glu Gln Ser Leu His Ser Phe His Thr Leu Phe Cys Arg Arg 
        275                 280                 285             


Cys Phe Lys Tyr Asp Cys Phe Leu His Pro Phe His Ala Thr Pro Asn 
    290                 295                 300                 


Thr Tyr Lys Arg Lys Asn Thr Glu Thr Ala Leu Asp Asn Lys Pro Cys 
305                 310                 315                 320 


Gly Pro Gln Cys Tyr Gln His Leu Glu Gly Ala Lys Glu Phe Ala Ala 
                325                 330                 335     


Ala Leu Thr Ala Glu Arg Ile Lys Thr Pro Pro Lys Arg Pro Gly Gly 
            340                 345                 350         


Arg Arg Arg Gly Arg Leu Pro Asn Asn Ser Ser Arg Pro Ser Thr Pro 
        355                 360                 365             


Thr Ile Asn Val Leu Glu Ser Lys Asp Thr Asp Ser Asp Arg Glu Ala 
    370                 375                 380                 


Gly Thr Glu Thr Gly Gly Glu Asn Asn Asp Lys Glu Glu Glu Glu Lys 
385                 390                 395                 400 


Lys Asp Glu Thr Ser Ser Ser Ser Glu Ala Asn Ser Arg Cys Gln Thr 
                405                 410                 415     


Pro Ile Lys Met Lys Pro Asn Ile Glu Pro Pro Glu Asn Val Glu Trp 
            420                 425                 430         


Ser Gly Ala Glu Ala Ser Met Phe Arg Val Leu Ile Gly Thr Tyr Tyr 
        435                 440                 445             


Asp Asn Phe Cys Ala Ile Ala Arg Leu Ile Gly Thr Lys Thr Cys Arg 
    450                 455                 460                 


Gln Val Tyr Glu Phe Arg Val Lys Glu Ser Ser Ile Ile Ala Pro Ala 
465                 470                 475                 480 


Pro Ala Glu Asp Val Asp Thr Pro Pro Arg Lys Lys Lys Arg Lys His 
                485                 490                 495     


Arg Leu Trp Ala Ala His Cys Arg Lys Ile Gln Leu Lys Lys Asp Gly 
            500                 505                 510         


Ser Ser Asn His Val Tyr Asn Tyr Gln Pro Cys Asp His Pro Arg Gln 
        515                 520                 525             


Pro Cys Asp Ser Ser Cys Pro Cys Val Ile Ala Gln Asn Phe Cys Glu 
    530                 535                 540                 


Lys Phe Cys Gln Cys Ser Ser Glu Cys Gln Asn Arg Phe Pro Gly Cys 
545                 550                 555                 560 


Arg Cys Lys Ala Gln Cys Asn Thr Lys Gln Cys Pro Cys Tyr Leu Ala 
                565                 570                 575     


Val Arg Glu Cys Asp Pro Asp Leu Cys Leu Thr Cys Gly Ala Ala Asp 
            580                 585                 590         


His Trp Asp Ser Lys Asn Val Ser Cys Lys Asn Cys Ser Ile Gln Arg 
        595                 600                 605             


Gly Ser Lys Lys His Leu Leu Leu Ala Pro Ser Asp Val Ala Gly Trp 
    610                 615                 620                 


Gly Ile Phe Ile Lys Asp Pro Val Gln Lys Asn Glu Phe Ile Ser Glu 
625                 630                 635                 640 


Tyr Cys Gly Glu Ile Ile Ser Gln Asp Glu Ala Asp Arg Arg Gly Lys 
                645                 650                 655     


Val Tyr Asp Lys Tyr Met Cys Ser Phe Leu Phe Asn Leu Asn Asn Asp 
            660                 665                 670         


Phe Val Val Asp Ala Thr Arg Lys Gly Asn Lys Ile Arg Phe Ala Asn 
        675                 680                 685             


His Ser Val Asn Pro Asn Cys Tyr Ala Lys Val Met Met Val Asn Gly 
    690                 695                 700                 


Asp His Arg Ile Gly Ile Phe Ala Lys Arg Ala Ile Gln Thr Gly Glu 
705                 710                 715                 720 


Glu Leu Phe Phe Asp Tyr Arg Tyr Ser Gln Ala Asp Ala Leu Lys Tyr 
                725                 730                 735     


Val Gly Ile Glu Arg Glu Met Glu Ile Pro 
            740                 745     


<210>  2
<211>  2723
<212>  DNA
<213>  Homo sapiens

<400>  2
ggcggcgctt gattgggctg ggggggccaa ataaaagcga tggcgattgg gctgccgcgt       60

ttggcgctcg gtccggtcgc gtccgacacc cggtgggact cagaaggcag tggagccccg      120

gcggcggcgg cggcggcgcg cgggggcgac gcgcgggaac aacgcgagtc ggcgcgcggg      180

acgaagaata atcatgggcc agactgggaa gaaatctgag aagggaccag tttgttggcg      240

gaagcgtgta aaatcagagt acatgcgact gagacagctc aagaggttca gacgagctga      300

tgaagtaaag agtatgttta gttccaatcg tcagaaaatt ttggaaagaa cggaaatctt      360

aaaccaagaa tggaaacagc gaaggataca gcctgtgcac atcctgactt ctgtgagctc      420

attgcgcggg actagggagt gttcggtgac cagtgacttg gattttccaa cacaagtcat      480

cccattaaag actctgaatg cagttgcttc agtacccata atgtattctt ggtctcccct      540

acagcagaat tttatggtgg aagatgaaac tgttttacat aacattcctt atatgggaga      600

tgaagtttta gatcaggatg gtactttcat tgaagaacta ataaaaaatt atgatgggaa      660

agtacacggg gatagagaat gtgggtttat aaatgatgaa atttttgtgg agttggtgaa      720

tgcccttggt caatataatg atgatgacga tgatgatgat ggagacgatc ctgaagaaag      780

agaagaaaag cagaaagatc tggaggatca ccgagatgat aaagaaagcc gcccacctcg      840

gaaatttcct tctgataaaa tttttgaagc catttcctca atgtttccag ataagggcac      900

agcagaagaa ctaaaggaaa aatataaaga actcaccgaa cagcagctcc caggcgcact      960

tcctcctgaa tgtaccccca acatagatgg accaaatgct aaatctgttc agagagagca     1020

aagcttacac tcctttcata cgcttttctg taggcgatgt tttaaatatg actgcttcct     1080

acatcgtaag tgcaattatt cttttcatgc aacacccaac acttataagc ggaagaacac     1140

agaaacagct ctagacaaca aaccttgtgg accacagtgt taccagcatt tggagggagc     1200

aaaggagttt gctgctgctc tcaccgctga gcggataaag accccaccaa aacgtccagg     1260

aggccgcaga agaggacggc ttcccaataa cagtagcagg cccagcaccc ccaccattaa     1320

tgtgctggaa tcaaaggata cagacagtga tagggaagca gggactgaaa cggggggaga     1380

gaacaatgat aaagaagaag aagagaagaa agatgaaact tcgagctcct ctgaagcaaa     1440

ttctcggtgt caaacaccaa taaagatgaa gccaaatatt gaacctcctg agaatgtgga     1500

gtggagtggt gctgaagcct caatgtttag agtcctcatt ggcacttact atgacaattt     1560

ctgtgccatt gctaggttaa ttgggaccaa aacatgtaga caggtgtatg agtttagagt     1620

caaagaatct agcatcatag ctccagctcc cgctgaggat gtggatactc ctccaaggaa     1680

aaagaagagg aaacaccggt tgtgggctgc acactgcaga aagatacagc tgaaaaagga     1740

cggctcctct aaccatgttt acaactatca accctgtgat catccacggc agccttgtga     1800

cagttcgtgc ccttgtgtga tagcacaaaa tttttgtgaa aagttttgtc aatgtagttc     1860

agagtgtcaa aaccgctttc cgggatgccg ctgcaaagca cagtgcaaca ccaagcagtg     1920

cccgtgctac ctggctgtcc gagagtgtga ccctgacctc tgtcttactt gtggagccgc     1980

tgaccattgg gacagtaaaa atgtgtcctg caagaactgc agtattcagc ggggctccaa     2040

aaagcatcta ttgctggcac catctgacgt ggcaggctgg gggattttta tcaaagatcc     2100

tgtgcagaaa aatgaattca tctcagaata ctgtggagag attatttctc aagatgaagc     2160

tgacagaaga gggaaagtgt atgataaata catgtgcagc tttctgttca acttgaacaa     2220

tgattttgtg gtggatgcaa cccgcaaggg taacaaaatt cgttttgcaa atcattcggt     2280

aaatccaaac tgctatgcaa aagttatgat ggttaacggt gatcacagga taggtatttt     2340

tgccaagaga gccatccaga ctggcgaaga gctgtttttt gattacagat acagccaggc     2400

tgatgccctg aagtatgtcg gcatcgaaag agaaatggaa atcccttgac atctgctacc     2460

tcctcccccc tcctctgaaa cagctgcctt agcttcagga acctcgagta ctgtgggcaa     2520

tttagaaaaa gaacatgcag tttgaaattc tgaatttgca aagtactgta agaataattt     2580

atagtaatga gtttaaaaat caacttttta ttgccttctc accagctgca aagtgttttg     2640

taccagtgaa tttttgcaat aatgcagtat ggtacatttt tcaactttga ataaagaata     2700

cttgaacttg tccttgttga atc                                             2723


<210>  3
<211>  751
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Gly Gln Thr Gly Lys Lys Ser Glu Lys Gly Pro Val Cys Trp Arg 
1               5                   10                  15      


Lys Arg Val Lys Ser Glu Tyr Met Arg Leu Arg Gln Leu Lys Arg Phe 
            20                  25                  30          


Arg Arg Ala Asp Glu Val Lys Ser Met Phe Ser Ser Asn Arg Gln Lys 
        35                  40                  45              


Ile Leu Glu Arg Thr Glu Ile Leu Asn Gln Glu Trp Lys Gln Arg Arg 
    50                  55                  60                  


Ile Gln Pro Val His Ile Leu Thr Ser Val Ser Ser Leu Arg Gly Thr 
65                  70                  75                  80  


Arg Glu Cys Ser Val Thr Ser Asp Leu Asp Phe Pro Thr Gln Val Ile 
                85                  90                  95      


Pro Leu Lys Thr Leu Asn Ala Val Ala Ser Val Pro Ile Met Tyr Ser 
            100                 105                 110         


Trp Ser Pro Leu Gln Gln Asn Phe Met Val Glu Asp Glu Thr Val Leu 
        115                 120                 125             


His Asn Ile Pro Tyr Met Gly Asp Glu Val Leu Asp Gln Asp Gly Thr 
    130                 135                 140                 


Phe Ile Glu Glu Leu Ile Lys Asn Tyr Asp Gly Lys Val His Gly Asp 
145                 150                 155                 160 


Arg Glu Cys Gly Phe Ile Asn Asp Glu Ile Phe Val Glu Leu Val Asn 
                165                 170                 175     


Ala Leu Gly Gln Tyr Asn Asp Asp Asp Asp Asp Asp Asp Gly Asp Asp 
            180                 185                 190         


Pro Glu Glu Arg Glu Glu Lys Gln Lys Asp Leu Glu Asp His Arg Asp 
        195                 200                 205             


Asp Lys Glu Ser Arg Pro Pro Arg Lys Phe Pro Ser Asp Lys Ile Phe 
    210                 215                 220                 


Glu Ala Ile Ser Ser Met Phe Pro Asp Lys Gly Thr Ala Glu Glu Leu 
225                 230                 235                 240 


Lys Glu Lys Tyr Lys Glu Leu Thr Glu Gln Gln Leu Pro Gly Ala Leu 
                245                 250                 255     


Pro Pro Glu Cys Thr Pro Asn Ile Asp Gly Pro Asn Ala Lys Ser Val 
            260                 265                 270         


Gln Arg Glu Gln Ser Leu His Ser Phe His Thr Leu Phe Cys Arg Arg 
        275                 280                 285             


Cys Phe Lys Tyr Asp Cys Phe Leu His Arg Lys Cys Asn Tyr Ser Phe 
    290                 295                 300                 


His Ala Thr Pro Asn Thr Tyr Lys Arg Lys Asn Thr Glu Thr Ala Leu 
305                 310                 315                 320 


Asp Asn Lys Pro Cys Gly Pro Gln Cys Tyr Gln His Leu Glu Gly Ala 
                325                 330                 335     


Lys Glu Phe Ala Ala Ala Leu Thr Ala Glu Arg Ile Lys Thr Pro Pro 
            340                 345                 350         


Lys Arg Pro Gly Gly Arg Arg Arg Gly Arg Leu Pro Asn Asn Ser Ser 
        355                 360                 365             


Arg Pro Ser Thr Pro Thr Ile Asn Val Leu Glu Ser Lys Asp Thr Asp 
    370                 375                 380                 


Ser Asp Arg Glu Ala Gly Thr Glu Thr Gly Gly Glu Asn Asn Asp Lys 
385                 390                 395                 400 


Glu Glu Glu Glu Lys Lys Asp Glu Thr Ser Ser Ser Ser Glu Ala Asn 
                405                 410                 415     


Ser Arg Cys Gln Thr Pro Ile Lys Met Lys Pro Asn Ile Glu Pro Pro 
            420                 425                 430         


Glu Asn Val Glu Trp Ser Gly Ala Glu Ala Ser Met Phe Arg Val Leu 
        435                 440                 445             


Ile Gly Thr Tyr Tyr Asp Asn Phe Cys Ala Ile Ala Arg Leu Ile Gly 
    450                 455                 460                 


Thr Lys Thr Cys Arg Gln Val Tyr Glu Phe Arg Val Lys Glu Ser Ser 
465                 470                 475                 480 


Ile Ile Ala Pro Ala Pro Ala Glu Asp Val Asp Thr Pro Pro Arg Lys 
                485                 490                 495     


Lys Lys Arg Lys His Arg Leu Trp Ala Ala His Cys Arg Lys Ile Gln 
            500                 505                 510         


Leu Lys Lys Asp Gly Ser Ser Asn His Val Tyr Asn Tyr Gln Pro Cys 
        515                 520                 525             


Asp His Pro Arg Gln Pro Cys Asp Ser Ser Cys Pro Cys Val Ile Ala 
    530                 535                 540                 


Gln Asn Phe Cys Glu Lys Phe Cys Gln Cys Ser Ser Glu Cys Gln Asn 
545                 550                 555                 560 


Arg Phe Pro Gly Cys Arg Cys Lys Ala Gln Cys Asn Thr Lys Gln Cys 
                565                 570                 575     


Pro Cys Tyr Leu Ala Val Arg Glu Cys Asp Pro Asp Leu Cys Leu Thr 
            580                 585                 590         


Cys Gly Ala Ala Asp His Trp Asp Ser Lys Asn Val Ser Cys Lys Asn 
        595                 600                 605             


Cys Ser Ile Gln Arg Gly Ser Lys Lys His Leu Leu Leu Ala Pro Ser 
    610                 615                 620                 


Asp Val Ala Gly Trp Gly Ile Phe Ile Lys Asp Pro Val Gln Lys Asn 
625                 630                 635                 640 


Glu Phe Ile Ser Glu Tyr Cys Gly Glu Ile Ile Ser Gln Asp Glu Ala 
                645                 650                 655     


Asp Arg Arg Gly Lys Val Tyr Asp Lys Tyr Met Cys Ser Phe Leu Phe 
            660                 665                 670         


Asn Leu Asn Asn Asp Phe Val Val Asp Ala Thr Arg Lys Gly Asn Lys 
        675                 680                 685             


Ile Arg Phe Ala Asn His Ser Val Asn Pro Asn Cys Tyr Ala Lys Val 
    690                 695                 700                 


Met Met Val Asn Gly Asp His Arg Ile Gly Ile Phe Ala Lys Arg Ala 
705                 710                 715                 720 


Ile Gln Thr Gly Glu Glu Leu Phe Phe Asp Tyr Arg Tyr Ser Gln Ala 
                725                 730                 735     


Asp Ala Leu Lys Tyr Val Gly Ile Glu Arg Glu Met Glu Ile Pro 
            740                 745                 750     


<210>  4
<211>  2591
<212>  DNA
<213>  Homo sapiens

<400>  4
ggcggcgctt gattgggctg ggggggccaa ataaaagcga tggcgattgg gctgccgcgt       60

ttggcgctcg gtccggtcgc gtccgacacc cggtgggact cagaaggcag tggagccccg      120

gcggcggcgg cggcggcgcg cgggggcgac gcgcgggaac aacgcgagtc ggcgcgcggg      180

acgaagaata atcatgggcc agactgggaa gaaatctgag aagggaccag tttgttggcg      240

gaagcgtgta aaatcagagt acatgcgact gagacagctc aagaggttca gacgagctga      300

tgaagtaaag agtatgttta gttccaatcg tcagaaaatt ttggaaagaa cggaaatctt      360

aaaccaagaa tggaaacagc gaaggataca gcctgtgcac atcctgactt ctgtgagctc      420

attgcgcggg actagggagg tggaagatga aactgtttta cataacattc cttatatggg      480

agatgaagtt ttagatcagg atggtacttt cattgaagaa ctaataaaaa attatgatgg      540

gaaagtacac ggggatagag aatgtgggtt tataaatgat gaaatttttg tggagttggt      600

gaatgccctt ggtcaatata atgatgatga cgatgatgat gatggagacg atcctgaaga      660

aagagaagaa aagcagaaag atctggagga tcaccgagat gataaagaaa gccgcccacc      720

tcggaaattt ccttctgata aaatttttga agccatttcc tcaatgtttc cagataaggg      780

cacagcagaa gaactaaagg aaaaatataa agaactcacc gaacagcagc tcccaggcgc      840

acttcctcct gaatgtaccc ccaacataga tggaccaaat gctaaatctg ttcagagaga      900

gcaaagctta cactcctttc atacgctttt ctgtaggcga tgttttaaat atgactgctt      960

cctacatcct tttcatgcaa cacccaacac ttataagcgg aagaacacag aaacagctct     1020

agacaacaaa ccttgtggac cacagtgtta ccagcatttg gagggagcaa aggagtttgc     1080

tgctgctctc accgctgagc ggataaagac cccaccaaaa cgtccaggag gccgcagaag     1140

aggacggctt cccaataaca gtagcaggcc cagcaccccc accattaatg tgctggaatc     1200

aaaggataca gacagtgata gggaagcagg gactgaaacg gggggagaga acaatgataa     1260

agaagaagaa gagaagaaag atgaaacttc gagctcctct gaagcaaatt ctcggtgtca     1320

aacaccaata aagatgaagc caaatattga acctcctgag aatgtggagt ggagtggtgc     1380

tgaagcctca atgtttagag tcctcattgg cacttactat gacaatttct gtgccattgc     1440

taggttaatt gggaccaaaa catgtagaca ggtgtatgag tttagagtca aagaatctag     1500

catcatagct ccagctcccg ctgaggatgt ggatactcct ccaaggaaaa agaagaggaa     1560

acaccggttg tgggctgcac actgcagaaa gatacagctg aaaaaggacg gctcctctaa     1620

ccatgtttac aactatcaac cctgtgatca tccacggcag ccttgtgaca gttcgtgccc     1680

ttgtgtgata gcacaaaatt tttgtgaaaa gttttgtcaa tgtagttcag agtgtcaaaa     1740

ccgctttccg ggatgccgct gcaaagcaca gtgcaacacc aagcagtgcc cgtgctacct     1800

ggctgtccga gagtgtgacc ctgacctctg tcttacttgt ggagccgctg accattggga     1860

cagtaaaaat gtgtcctgca agaactgcag tattcagcgg ggctccaaaa agcatctatt     1920

gctggcacca tctgacgtgg caggctgggg gatttttatc aaagatcctg tgcagaaaaa     1980

tgaattcatc tcagaatact gtggagagat tatttctcaa gatgaagctg acagaagagg     2040

gaaagtgtat gataaataca tgtgcagctt tctgttcaac ttgaacaatg attttgtggt     2100

ggatgcaacc cgcaagggta acaaaattcg ttttgcaaat cattcggtaa atccaaactg     2160

ctatgcaaaa gttatgatgg ttaacggtga tcacaggata ggtatttttg ccaagagagc     2220

catccagact ggcgaagagc tgttttttga ttacagatac agccaggctg atgccctgaa     2280

gtatgtcggc atcgaaagag aaatggaaat cccttgacat ctgctacctc ctcccccctc     2340

ctctgaaaca gctgccttag cttcaggaac ctcgagtact gtgggcaatt tagaaaaaga     2400

acatgcagtt tgaaattctg aatttgcaaa gtactgtaag aataatttat agtaatgagt     2460

ttaaaaatca actttttatt gccttctcac cagctgcaaa gtgttttgta ccagtgaatt     2520

tttgcaataa tgcagtatgg tacatttttc aactttgaat aaagaatact tgaacttgtc     2580

cttgttgaat c                                                          2591


<210>  5
<211>  707
<212>  PRT
<213>  Homo sapiens

<400>  5

Met Gly Gln Thr Gly Lys Lys Ser Glu Lys Gly Pro Val Cys Trp Arg 
1               5                   10                  15      


Lys Arg Val Lys Ser Glu Tyr Met Arg Leu Arg Gln Leu Lys Arg Phe 
            20                  25                  30          


Arg Arg Ala Asp Glu Val Lys Ser Met Phe Ser Ser Asn Arg Gln Lys 
        35                  40                  45              


Ile Leu Glu Arg Thr Glu Ile Leu Asn Gln Glu Trp Lys Gln Arg Arg 
    50                  55                  60                  


Ile Gln Pro Val His Ile Leu Thr Ser Val Ser Ser Leu Arg Gly Thr 
65                  70                  75                  80  


Arg Glu Val Glu Asp Glu Thr Val Leu His Asn Ile Pro Tyr Met Gly 
                85                  90                  95      


Asp Glu Val Leu Asp Gln Asp Gly Thr Phe Ile Glu Glu Leu Ile Lys 
            100                 105                 110         


Asn Tyr Asp Gly Lys Val His Gly Asp Arg Glu Cys Gly Phe Ile Asn 
        115                 120                 125             


Asp Glu Ile Phe Val Glu Leu Val Asn Ala Leu Gly Gln Tyr Asn Asp 
    130                 135                 140                 


Asp Asp Asp Asp Asp Asp Gly Asp Asp Pro Glu Glu Arg Glu Glu Lys 
145                 150                 155                 160 


Gln Lys Asp Leu Glu Asp His Arg Asp Asp Lys Glu Ser Arg Pro Pro 
                165                 170                 175     


Arg Lys Phe Pro Ser Asp Lys Ile Phe Glu Ala Ile Ser Ser Met Phe 
            180                 185                 190         


Pro Asp Lys Gly Thr Ala Glu Glu Leu Lys Glu Lys Tyr Lys Glu Leu 
        195                 200                 205             


Thr Glu Gln Gln Leu Pro Gly Ala Leu Pro Pro Glu Cys Thr Pro Asn 
    210                 215                 220                 


Ile Asp Gly Pro Asn Ala Lys Ser Val Gln Arg Glu Gln Ser Leu His 
225                 230                 235                 240 


Ser Phe His Thr Leu Phe Cys Arg Arg Cys Phe Lys Tyr Asp Cys Phe 
                245                 250                 255     


Leu His Pro Phe His Ala Thr Pro Asn Thr Tyr Lys Arg Lys Asn Thr 
            260                 265                 270         


Glu Thr Ala Leu Asp Asn Lys Pro Cys Gly Pro Gln Cys Tyr Gln His 
        275                 280                 285             


Leu Glu Gly Ala Lys Glu Phe Ala Ala Ala Leu Thr Ala Glu Arg Ile 
    290                 295                 300                 


Lys Thr Pro Pro Lys Arg Pro Gly Gly Arg Arg Arg Gly Arg Leu Pro 
305                 310                 315                 320 


Asn Asn Ser Ser Arg Pro Ser Thr Pro Thr Ile Asn Val Leu Glu Ser 
                325                 330                 335     


Lys Asp Thr Asp Ser Asp Arg Glu Ala Gly Thr Glu Thr Gly Gly Glu 
            340                 345                 350         


Asn Asn Asp Lys Glu Glu Glu Glu Lys Lys Asp Glu Thr Ser Ser Ser 
        355                 360                 365             


Ser Glu Ala Asn Ser Arg Cys Gln Thr Pro Ile Lys Met Lys Pro Asn 
    370                 375                 380                 


Ile Glu Pro Pro Glu Asn Val Glu Trp Ser Gly Ala Glu Ala Ser Met 
385                 390                 395                 400 


Phe Arg Val Leu Ile Gly Thr Tyr Tyr Asp Asn Phe Cys Ala Ile Ala 
                405                 410                 415     


Arg Leu Ile Gly Thr Lys Thr Cys Arg Gln Val Tyr Glu Phe Arg Val 
            420                 425                 430         


Lys Glu Ser Ser Ile Ile Ala Pro Ala Pro Ala Glu Asp Val Asp Thr 
        435                 440                 445             


Pro Pro Arg Lys Lys Lys Arg Lys His Arg Leu Trp Ala Ala His Cys 
    450                 455                 460                 


Arg Lys Ile Gln Leu Lys Lys Asp Gly Ser Ser Asn His Val Tyr Asn 
465                 470                 475                 480 


Tyr Gln Pro Cys Asp His Pro Arg Gln Pro Cys Asp Ser Ser Cys Pro 
                485                 490                 495     


Cys Val Ile Ala Gln Asn Phe Cys Glu Lys Phe Cys Gln Cys Ser Ser 
            500                 505                 510         


Glu Cys Gln Asn Arg Phe Pro Gly Cys Arg Cys Lys Ala Gln Cys Asn 
        515                 520                 525             


Thr Lys Gln Cys Pro Cys Tyr Leu Ala Val Arg Glu Cys Asp Pro Asp 
    530                 535                 540                 


Leu Cys Leu Thr Cys Gly Ala Ala Asp His Trp Asp Ser Lys Asn Val 
545                 550                 555                 560 


Ser Cys Lys Asn Cys Ser Ile Gln Arg Gly Ser Lys Lys His Leu Leu 
                565                 570                 575     


Leu Ala Pro Ser Asp Val Ala Gly Trp Gly Ile Phe Ile Lys Asp Pro 
            580                 585                 590         


Val Gln Lys Asn Glu Phe Ile Ser Glu Tyr Cys Gly Glu Ile Ile Ser 
        595                 600                 605             


Gln Asp Glu Ala Asp Arg Arg Gly Lys Val Tyr Asp Lys Tyr Met Cys 
    610                 615                 620                 


Ser Phe Leu Phe Asn Leu Asn Asn Asp Phe Val Val Asp Ala Thr Arg 
625                 630                 635                 640 


Lys Gly Asn Lys Ile Arg Phe Ala Asn His Ser Val Asn Pro Asn Cys 
                645                 650                 655     


Tyr Ala Lys Val Met Met Val Asn Gly Asp His Arg Ile Gly Ile Phe 
            660                 665                 670         


Ala Lys Arg Ala Ile Gln Thr Gly Glu Glu Leu Phe Phe Asp Tyr Arg 
        675                 680                 685             


Tyr Ser Gln Ala Asp Ala Leu Lys Tyr Val Gly Ile Glu Arg Glu Met 
    690                 695                 700                 


Glu Ile Pro 
705         


<210>  6
<211>  200
<212>  PRT
<213>  Homo sapiens

<400>  6

Ser Cys Pro Cys Val Ile Ala Gln Asn Phe Cys Glu Lys Phe Cys Gln 
1               5                   10                  15      


Cys Ser Ser Glu Cys Gln Asn Arg Phe Pro Gly Cys Arg Cys Lys Ala 
            20                  25                  30          


Gln Cys Asn Thr Lys Gln Cys Pro Cys Tyr Leu Ala Val Arg Glu Cys 
        35                  40                  45              


Asp Pro Asp Leu Cys Leu Thr Cys Gly Ala Ala Asp His Trp Asp Ser 
    50                  55                  60                  


Lys Asn Val Ser Cys Lys Asn Cys Ser Ile Gln Arg Gly Ser Lys Lys 
65                  70                  75                  80  


His Leu Leu Leu Ala Pro Ser Asp Val Ala Gly Trp Gly Ile Phe Ile 
                85                  90                  95      


Lys Asp Pro Val Gln Lys Asn Glu Phe Ile Ser Glu Tyr Cys Gly Glu 
            100                 105                 110         


Ile Ile Ser Gln Asp Glu Ala Asp Arg Arg Gly Lys Val Tyr Asp Lys 
        115                 120                 125             


Tyr Met Cys Ser Phe Leu Phe Asn Leu Asn Asn Asp Phe Val Val Asp 
    130                 135                 140                 


Ala Thr Arg Lys Gly Asn Lys Ile Arg Phe Ala Asn His Ser Val Asn 
145                 150                 155                 160 


Pro Asn Cys Tyr Ala Lys Val Met Met Val Asn Gly Asp His Arg Ile 
                165                 170                 175     


Gly Ile Phe Ala Lys Arg Ala Ile Gln Thr Gly Glu Glu Leu Phe Phe 
            180                 185                 190         


Asp Tyr Arg Tyr Ser Gln Ala Asp 
        195                 200 


<210>  7
<211>  114
<212>  PRT
<213>  Homo sapiens

<400>  7

His Leu Leu Leu Ala Pro Ser Asp Val Ala Gly Trp Gly Ile Phe Ile 
1               5                   10                  15      


Lys Asp Pro Val Gln Lys Asn Glu Phe Ile Ser Glu Tyr Cys Gly Glu 
            20                  25                  30          


Ile Ile Ser Gln Asp Glu Ala Asp Arg Arg Gly Lys Val Tyr Asp Lys 
        35                  40                  45              


Tyr Met Cys Ser Phe Leu Phe Asn Leu Asn Asn Asp Phe Val Val Asp 
    50                  55                  60                  


Ala Thr Arg Lys Gly Asn Lys Ile Arg Phe Ala Asn His Ser Val Asn 
65                  70                  75                  80  


Pro Asn Cys Tyr Ala Lys Val Met Met Val Asn Gly Asp His Arg Ile 
                85                  90                  95      


Gly Ile Phe Ala Lys Arg Ala Ile Gln Thr Gly Glu Glu Leu Phe Phe 
            100                 105                 110         


Asp Tyr 
        


<210>  8
<211>  342
<212>  DNA
<213>  Homo sapiens

<400>  8
catctattgc tggcaccatc tgacgtggca ggctggggga tttttatcaa agatcctgtg       60

cagaaaaatg aattcatctc agaatactgt ggagagatta tttctcaaga tgaagctgac      120

agaagaggga aagtgtatga taaatacatg tgcagctttc tgttcaactt gaacaatgat      180

tttgtggtgg atgcaacccg caagggtaac aaaattcgtt ttgcaaatca ttcggtaaat      240

ccaaactgct atgcaaaagt tatgatggtt aacggtgatc acaggatagg tatttttgcc      300

aagagagcca tccagactgg cgaagagctg ttttttgatt ac                         342


<210>  9
<211>  746
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (641)..(641)
<223>  Wherein "X" can be any amino acid residue other than tyrosine "Y"

<400>  9

Met Gly Gln Thr Gly Lys Lys Ser Glu Lys Gly Pro Val Cys Trp Arg 
1               5                   10                  15      


Lys Arg Val Lys Ser Glu Tyr Met Arg Leu Arg Gln Leu Lys Arg Phe 
            20                  25                  30          


Arg Arg Ala Asp Glu Val Lys Ser Met Phe Ser Ser Asn Arg Gln Lys 
        35                  40                  45              


Ile Leu Glu Arg Thr Glu Ile Leu Asn Gln Glu Trp Lys Gln Arg Arg 
    50                  55                  60                  


Ile Gln Pro Val His Ile Leu Thr Ser Val Ser Ser Leu Arg Gly Thr 
65                  70                  75                  80  


Arg Glu Cys Ser Val Thr Ser Asp Leu Asp Phe Pro Thr Gln Val Ile 
                85                  90                  95      


Pro Leu Lys Thr Leu Asn Ala Val Ala Ser Val Pro Ile Met Tyr Ser 
            100                 105                 110         


Trp Ser Pro Leu Gln Gln Asn Phe Met Val Glu Asp Glu Thr Val Leu 
        115                 120                 125             


His Asn Ile Pro Tyr Met Gly Asp Glu Val Leu Asp Gln Asp Gly Thr 
    130                 135                 140                 


Phe Ile Glu Glu Leu Ile Lys Asn Tyr Asp Gly Lys Val His Gly Asp 
145                 150                 155                 160 


Arg Glu Cys Gly Phe Ile Asn Asp Glu Ile Phe Val Glu Leu Val Asn 
                165                 170                 175     


Ala Leu Gly Gln Tyr Asn Asp Asp Asp Asp Asp Asp Asp Gly Asp Asp 
            180                 185                 190         


Pro Glu Glu Arg Glu Glu Lys Gln Lys Asp Leu Glu Asp His Arg Asp 
        195                 200                 205             


Asp Lys Glu Ser Arg Pro Pro Arg Lys Phe Pro Ser Asp Lys Ile Phe 
    210                 215                 220                 


Glu Ala Ile Ser Ser Met Phe Pro Asp Lys Gly Thr Ala Glu Glu Leu 
225                 230                 235                 240 


Lys Glu Lys Tyr Lys Glu Leu Thr Glu Gln Gln Leu Pro Gly Ala Leu 
                245                 250                 255     


Pro Pro Glu Cys Thr Pro Asn Ile Asp Gly Pro Asn Ala Lys Ser Val 
            260                 265                 270         


Gln Arg Glu Gln Ser Leu His Ser Phe His Thr Leu Phe Cys Arg Arg 
        275                 280                 285             


Cys Phe Lys Tyr Asp Cys Phe Leu His Pro Phe His Ala Thr Pro Asn 
    290                 295                 300                 


Thr Tyr Lys Arg Lys Asn Thr Glu Thr Ala Leu Asp Asn Lys Pro Cys 
305                 310                 315                 320 


Gly Pro Gln Cys Tyr Gln His Leu Glu Gly Ala Lys Glu Phe Ala Ala 
                325                 330                 335     


Ala Leu Thr Ala Glu Arg Ile Lys Thr Pro Pro Lys Arg Pro Gly Gly 
            340                 345                 350         


Arg Arg Arg Gly Arg Leu Pro Asn Asn Ser Ser Arg Pro Ser Thr Pro 
        355                 360                 365             


Thr Ile Asn Val Leu Glu Ser Lys Asp Thr Asp Ser Asp Arg Glu Ala 
    370                 375                 380                 


Gly Thr Glu Thr Gly Gly Glu Asn Asn Asp Lys Glu Glu Glu Glu Lys 
385                 390                 395                 400 


Lys Asp Glu Thr Ser Ser Ser Ser Glu Ala Asn Ser Arg Cys Gln Thr 
                405                 410                 415     


Pro Ile Lys Met Lys Pro Asn Ile Glu Pro Pro Glu Asn Val Glu Trp 
            420                 425                 430         


Ser Gly Ala Glu Ala Ser Met Phe Arg Val Leu Ile Gly Thr Tyr Tyr 
        435                 440                 445             


Asp Asn Phe Cys Ala Ile Ala Arg Leu Ile Gly Thr Lys Thr Cys Arg 
    450                 455                 460                 


Gln Val Tyr Glu Phe Arg Val Lys Glu Ser Ser Ile Ile Ala Pro Ala 
465                 470                 475                 480 


Pro Ala Glu Asp Val Asp Thr Pro Pro Arg Lys Lys Lys Arg Lys His 
                485                 490                 495     


Arg Leu Trp Ala Ala His Cys Arg Lys Ile Gln Leu Lys Lys Asp Gly 
            500                 505                 510         


Ser Ser Asn His Val Tyr Asn Tyr Gln Pro Cys Asp His Pro Arg Gln 
        515                 520                 525             


Pro Cys Asp Ser Ser Cys Pro Cys Val Ile Ala Gln Asn Phe Cys Glu 
    530                 535                 540                 


Lys Phe Cys Gln Cys Ser Ser Glu Cys Gln Asn Arg Phe Pro Gly Cys 
545                 550                 555                 560 


Arg Cys Lys Ala Gln Cys Asn Thr Lys Gln Cys Pro Cys Tyr Leu Ala 
                565                 570                 575     


Val Arg Glu Cys Asp Pro Asp Leu Cys Leu Thr Cys Gly Ala Ala Asp 
            580                 585                 590         


His Trp Asp Ser Lys Asn Val Ser Cys Lys Asn Cys Ser Ile Gln Arg 
        595                 600                 605             


Gly Ser Lys Lys His Leu Leu Leu Ala Pro Ser Asp Val Ala Gly Trp 
    610                 615                 620                 


Gly Ile Phe Ile Lys Asp Pro Val Gln Lys Asn Glu Phe Ile Ser Glu 
625                 630                 635                 640 


Xaa Cys Gly Glu Ile Ile Ser Gln Asp Glu Ala Asp Arg Arg Gly Lys 
                645                 650                 655     


Val Tyr Asp Lys Tyr Met Cys Ser Phe Leu Phe Asn Leu Asn Asn Asp 
            660                 665                 670         


Phe Val Val Asp Ala Thr Arg Lys Gly Asn Lys Ile Arg Phe Ala Asn 
        675                 680                 685             


His Ser Val Asn Pro Asn Cys Tyr Ala Lys Val Met Met Val Asn Gly 
    690                 695                 700                 


Asp His Arg Ile Gly Ile Phe Ala Lys Arg Ala Ile Gln Thr Gly Glu 
705                 710                 715                 720 


Glu Leu Phe Phe Asp Tyr Arg Tyr Ser Gln Ala Asp Ala Leu Lys Tyr 
                725                 730                 735     


Val Gly Ile Glu Arg Glu Met Glu Ile Pro 
            740                 745     


<210>  10
<211>  746
<212>  PRT
<213>  Homo sapiens

<400>  10

Met Gly Gln Thr Gly Lys Lys Ser Glu Lys Gly Pro Val Cys Trp Arg 
1               5                   10                  15      


Lys Arg Val Lys Ser Glu Tyr Met Arg Leu Arg Gln Leu Lys Arg Phe 
            20                  25                  30          


Arg Arg Ala Asp Glu Val Lys Ser Met Phe Ser Ser Asn Arg Gln Lys 
        35                  40                  45              


Ile Leu Glu Arg Thr Glu Ile Leu Asn Gln Glu Trp Lys Gln Arg Arg 
    50                  55                  60                  


Ile Gln Pro Val His Ile Leu Thr Ser Val Ser Ser Leu Arg Gly Thr 
65                  70                  75                  80  


Arg Glu Cys Ser Val Thr Ser Asp Leu Asp Phe Pro Thr Gln Val Ile 
                85                  90                  95      


Pro Leu Lys Thr Leu Asn Ala Val Ala Ser Val Pro Ile Met Tyr Ser 
            100                 105                 110         


Trp Ser Pro Leu Gln Gln Asn Phe Met Val Glu Asp Glu Thr Val Leu 
        115                 120                 125             


His Asn Ile Pro Tyr Met Gly Asp Glu Val Leu Asp Gln Asp Gly Thr 
    130                 135                 140                 


Phe Ile Glu Glu Leu Ile Lys Asn Tyr Asp Gly Lys Val His Gly Asp 
145                 150                 155                 160 


Arg Glu Cys Gly Phe Ile Asn Asp Glu Ile Phe Val Glu Leu Val Asn 
                165                 170                 175     


Ala Leu Gly Gln Tyr Asn Asp Asp Asp Asp Asp Asp Asp Gly Asp Asp 
            180                 185                 190         


Pro Glu Glu Arg Glu Glu Lys Gln Lys Asp Leu Glu Asp His Arg Asp 
        195                 200                 205             


Asp Lys Glu Ser Arg Pro Pro Arg Lys Phe Pro Ser Asp Lys Ile Phe 
    210                 215                 220                 


Glu Ala Ile Ser Ser Met Phe Pro Asp Lys Gly Thr Ala Glu Glu Leu 
225                 230                 235                 240 


Lys Glu Lys Tyr Lys Glu Leu Thr Glu Gln Gln Leu Pro Gly Ala Leu 
                245                 250                 255     


Pro Pro Glu Cys Thr Pro Asn Ile Asp Gly Pro Asn Ala Lys Ser Val 
            260                 265                 270         


Gln Arg Glu Gln Ser Leu His Ser Phe His Thr Leu Phe Cys Arg Arg 
        275                 280                 285             


Cys Phe Lys Tyr Asp Cys Phe Leu His Pro Phe His Ala Thr Pro Asn 
    290                 295                 300                 


Thr Tyr Lys Arg Lys Asn Thr Glu Thr Ala Leu Asp Asn Lys Pro Cys 
305                 310                 315                 320 


Gly Pro Gln Cys Tyr Gln His Leu Glu Gly Ala Lys Glu Phe Ala Ala 
                325                 330                 335     


Ala Leu Thr Ala Glu Arg Ile Lys Thr Pro Pro Lys Arg Pro Gly Gly 
            340                 345                 350         


Arg Arg Arg Gly Arg Leu Pro Asn Asn Ser Ser Arg Pro Ser Thr Pro 
        355                 360                 365             


Thr Ile Asn Val Leu Glu Ser Lys Asp Thr Asp Ser Asp Arg Glu Ala 
    370                 375                 380                 


Gly Thr Glu Thr Gly Gly Glu Asn Asn Asp Lys Glu Glu Glu Glu Lys 
385                 390                 395                 400 


Lys Asp Glu Thr Ser Ser Ser Ser Glu Ala Asn Ser Arg Cys Gln Thr 
                405                 410                 415     


Pro Ile Lys Met Lys Pro Asn Ile Glu Pro Pro Glu Asn Val Glu Trp 
            420                 425                 430         


Ser Gly Ala Glu Ala Ser Met Phe Arg Val Leu Ile Gly Thr Tyr Tyr 
        435                 440                 445             


Asp Asn Phe Cys Ala Ile Ala Arg Leu Ile Gly Thr Lys Thr Cys Arg 
    450                 455                 460                 


Gln Val Tyr Glu Phe Arg Val Lys Glu Ser Ser Ile Ile Ala Pro Ala 
465                 470                 475                 480 


Pro Ala Glu Asp Val Asp Thr Pro Pro Arg Lys Lys Lys Arg Lys His 
                485                 490                 495     


Arg Leu Trp Ala Ala His Cys Arg Lys Ile Gln Leu Lys Lys Asp Gly 
            500                 505                 510         


Ser Ser Asn His Val Tyr Asn Tyr Gln Pro Cys Asp His Pro Arg Gln 
        515                 520                 525             


Pro Cys Asp Ser Ser Cys Pro Cys Val Ile Ala Gln Asn Phe Cys Glu 
    530                 535                 540                 


Lys Phe Cys Gln Cys Ser Ser Glu Cys Gln Asn Arg Phe Pro Gly Cys 
545                 550                 555                 560 


Arg Cys Lys Ala Gln Cys Asn Thr Lys Gln Cys Pro Cys Tyr Leu Ala 
                565                 570                 575     


Val Arg Glu Cys Asp Pro Asp Leu Cys Leu Thr Cys Gly Ala Ala Asp 
            580                 585                 590         


His Trp Asp Ser Lys Asn Val Ser Cys Lys Asn Cys Ser Ile Gln Arg 
        595                 600                 605             


Gly Ser Lys Lys His Leu Leu Leu Ala Pro Ser Asp Val Ala Gly Trp 
    610                 615                 620                 


Gly Ile Phe Ile Lys Asp Pro Val Gln Lys Asn Glu Phe Ile Ser Glu 
625                 630                 635                 640 


Phe Cys Gly Glu Ile Ile Ser Gln Asp Glu Ala Asp Arg Arg Gly Lys 
                645                 650                 655     


Val Tyr Asp Lys Tyr Met Cys Ser Phe Leu Phe Asn Leu Asn Asn Asp 
            660                 665                 670         


Phe Val Val Asp Ala Thr Arg Lys Gly Asn Lys Ile Arg Phe Ala Asn 
        675                 680                 685             


His Ser Val Asn Pro Asn Cys Tyr Ala Lys Val Met Met Val Asn Gly 
    690                 695                 700                 


Asp His Arg Ile Gly Ile Phe Ala Lys Arg Ala Ile Gln Thr Gly Glu 
705                 710                 715                 720 


Glu Leu Phe Phe Asp Tyr Arg Tyr Ser Gln Ala Asp Ala Leu Lys Tyr 
                725                 730                 735     


Val Gly Ile Glu Arg Glu Met Glu Ile Pro 
            740                 745     


<210>  11
<211>  746
<212>  PRT
<213>  Homo sapiens

<400>  11

Met Gly Gln Thr Gly Lys Lys Ser Glu Lys Gly Pro Val Cys Trp Arg 
1               5                   10                  15      


Lys Arg Val Lys Ser Glu Tyr Met Arg Leu Arg Gln Leu Lys Arg Phe 
            20                  25                  30          


Arg Arg Ala Asp Glu Val Lys Ser Met Phe Ser Ser Asn Arg Gln Lys 
        35                  40                  45              


Ile Leu Glu Arg Thr Glu Ile Leu Asn Gln Glu Trp Lys Gln Arg Arg 
    50                  55                  60                  


Ile Gln Pro Val His Ile Leu Thr Ser Val Ser Ser Leu Arg Gly Thr 
65                  70                  75                  80  


Arg Glu Cys Ser Val Thr Ser Asp Leu Asp Phe Pro Thr Gln Val Ile 
                85                  90                  95      


Pro Leu Lys Thr Leu Asn Ala Val Ala Ser Val Pro Ile Met Tyr Ser 
            100                 105                 110         


Trp Ser Pro Leu Gln Gln Asn Phe Met Val Glu Asp Glu Thr Val Leu 
        115                 120                 125             


His Asn Ile Pro Tyr Met Gly Asp Glu Val Leu Asp Gln Asp Gly Thr 
    130                 135                 140                 


Phe Ile Glu Glu Leu Ile Lys Asn Tyr Asp Gly Lys Val His Gly Asp 
145                 150                 155                 160 


Arg Glu Cys Gly Phe Ile Asn Asp Glu Ile Phe Val Glu Leu Val Asn 
                165                 170                 175     


Ala Leu Gly Gln Tyr Asn Asp Asp Asp Asp Asp Asp Asp Gly Asp Asp 
            180                 185                 190         


Pro Glu Glu Arg Glu Glu Lys Gln Lys Asp Leu Glu Asp His Arg Asp 
        195                 200                 205             


Asp Lys Glu Ser Arg Pro Pro Arg Lys Phe Pro Ser Asp Lys Ile Phe 
    210                 215                 220                 


Glu Ala Ile Ser Ser Met Phe Pro Asp Lys Gly Thr Ala Glu Glu Leu 
225                 230                 235                 240 


Lys Glu Lys Tyr Lys Glu Leu Thr Glu Gln Gln Leu Pro Gly Ala Leu 
                245                 250                 255     


Pro Pro Glu Cys Thr Pro Asn Ile Asp Gly Pro Asn Ala Lys Ser Val 
            260                 265                 270         


Gln Arg Glu Gln Ser Leu His Ser Phe His Thr Leu Phe Cys Arg Arg 
        275                 280                 285             


Cys Phe Lys Tyr Asp Cys Phe Leu His Pro Phe His Ala Thr Pro Asn 
    290                 295                 300                 


Thr Tyr Lys Arg Lys Asn Thr Glu Thr Ala Leu Asp Asn Lys Pro Cys 
305                 310                 315                 320 


Gly Pro Gln Cys Tyr Gln His Leu Glu Gly Ala Lys Glu Phe Ala Ala 
                325                 330                 335     


Ala Leu Thr Ala Glu Arg Ile Lys Thr Pro Pro Lys Arg Pro Gly Gly 
            340                 345                 350         


Arg Arg Arg Gly Arg Leu Pro Asn Asn Ser Ser Arg Pro Ser Thr Pro 
        355                 360                 365             


Thr Ile Asn Val Leu Glu Ser Lys Asp Thr Asp Ser Asp Arg Glu Ala 
    370                 375                 380                 


Gly Thr Glu Thr Gly Gly Glu Asn Asn Asp Lys Glu Glu Glu Glu Lys 
385                 390                 395                 400 


Lys Asp Glu Thr Ser Ser Ser Ser Glu Ala Asn Ser Arg Cys Gln Thr 
                405                 410                 415     


Pro Ile Lys Met Lys Pro Asn Ile Glu Pro Pro Glu Asn Val Glu Trp 
            420                 425                 430         


Ser Gly Ala Glu Ala Ser Met Phe Arg Val Leu Ile Gly Thr Tyr Tyr 
        435                 440                 445             


Asp Asn Phe Cys Ala Ile Ala Arg Leu Ile Gly Thr Lys Thr Cys Arg 
    450                 455                 460                 


Gln Val Tyr Glu Phe Arg Val Lys Glu Ser Ser Ile Ile Ala Pro Ala 
465                 470                 475                 480 


Pro Ala Glu Asp Val Asp Thr Pro Pro Arg Lys Lys Lys Arg Lys His 
                485                 490                 495     


Arg Leu Trp Ala Ala His Cys Arg Lys Ile Gln Leu Lys Lys Asp Gly 
            500                 505                 510         


Ser Ser Asn His Val Tyr Asn Tyr Gln Pro Cys Asp His Pro Arg Gln 
        515                 520                 525             


Pro Cys Asp Ser Ser Cys Pro Cys Val Ile Ala Gln Asn Phe Cys Glu 
    530                 535                 540                 


Lys Phe Cys Gln Cys Ser Ser Glu Cys Gln Asn Arg Phe Pro Gly Cys 
545                 550                 555                 560 


Arg Cys Lys Ala Gln Cys Asn Thr Lys Gln Cys Pro Cys Tyr Leu Ala 
                565                 570                 575     


Val Arg Glu Cys Asp Pro Asp Leu Cys Leu Thr Cys Gly Ala Ala Asp 
            580                 585                 590         


His Trp Asp Ser Lys Asn Val Ser Cys Lys Asn Cys Ser Ile Gln Arg 
        595                 600                 605             


Gly Ser Lys Lys His Leu Leu Leu Ala Pro Ser Asp Val Ala Gly Trp 
    610                 615                 620                 


Gly Ile Phe Ile Lys Asp Pro Val Gln Lys Asn Glu Phe Ile Ser Glu 
625                 630                 635                 640 


His Cys Gly Glu Ile Ile Ser Gln Asp Glu Ala Asp Arg Arg Gly Lys 
                645                 650                 655     


Val Tyr Asp Lys Tyr Met Cys Ser Phe Leu Phe Asn Leu Asn Asn Asp 
            660                 665                 670         


Phe Val Val Asp Ala Thr Arg Lys Gly Asn Lys Ile Arg Phe Ala Asn 
        675                 680                 685             


His Ser Val Asn Pro Asn Cys Tyr Ala Lys Val Met Met Val Asn Gly 
    690                 695                 700                 


Asp His Arg Ile Gly Ile Phe Ala Lys Arg Ala Ile Gln Thr Gly Glu 
705                 710                 715                 720 


Glu Leu Phe Phe Asp Tyr Arg Tyr Ser Gln Ala Asp Ala Leu Lys Tyr 
                725                 730                 735     


Val Gly Ile Glu Arg Glu Met Glu Ile Pro 
            740                 745     


<210>  12
<211>  746
<212>  PRT
<213>  Homo sapiens

<400>  12

Met Gly Gln Thr Gly Lys Lys Ser Glu Lys Gly Pro Val Cys Trp Arg 
1               5                   10                  15      


Lys Arg Val Lys Ser Glu Tyr Met Arg Leu Arg Gln Leu Lys Arg Phe 
            20                  25                  30          


Arg Arg Ala Asp Glu Val Lys Ser Met Phe Ser Ser Asn Arg Gln Lys 
        35                  40                  45              


Ile Leu Glu Arg Thr Glu Ile Leu Asn Gln Glu Trp Lys Gln Arg Arg 
    50                  55                  60                  


Ile Gln Pro Val His Ile Leu Thr Ser Val Ser Ser Leu Arg Gly Thr 
65                  70                  75                  80  


Arg Glu Cys Ser Val Thr Ser Asp Leu Asp Phe Pro Thr Gln Val Ile 
                85                  90                  95      


Pro Leu Lys Thr Leu Asn Ala Val Ala Ser Val Pro Ile Met Tyr Ser 
            100                 105                 110         


Trp Ser Pro Leu Gln Gln Asn Phe Met Val Glu Asp Glu Thr Val Leu 
        115                 120                 125             


His Asn Ile Pro Tyr Met Gly Asp Glu Val Leu Asp Gln Asp Gly Thr 
    130                 135                 140                 


Phe Ile Glu Glu Leu Ile Lys Asn Tyr Asp Gly Lys Val His Gly Asp 
145                 150                 155                 160 


Arg Glu Cys Gly Phe Ile Asn Asp Glu Ile Phe Val Glu Leu Val Asn 
                165                 170                 175     


Ala Leu Gly Gln Tyr Asn Asp Asp Asp Asp Asp Asp Asp Gly Asp Asp 
            180                 185                 190         


Pro Glu Glu Arg Glu Glu Lys Gln Lys Asp Leu Glu Asp His Arg Asp 
        195                 200                 205             


Asp Lys Glu Ser Arg Pro Pro Arg Lys Phe Pro Ser Asp Lys Ile Phe 
    210                 215                 220                 


Glu Ala Ile Ser Ser Met Phe Pro Asp Lys Gly Thr Ala Glu Glu Leu 
225                 230                 235                 240 


Lys Glu Lys Tyr Lys Glu Leu Thr Glu Gln Gln Leu Pro Gly Ala Leu 
                245                 250                 255     


Pro Pro Glu Cys Thr Pro Asn Ile Asp Gly Pro Asn Ala Lys Ser Val 
            260                 265                 270         


Gln Arg Glu Gln Ser Leu His Ser Phe His Thr Leu Phe Cys Arg Arg 
        275                 280                 285             


Cys Phe Lys Tyr Asp Cys Phe Leu His Pro Phe His Ala Thr Pro Asn 
    290                 295                 300                 


Thr Tyr Lys Arg Lys Asn Thr Glu Thr Ala Leu Asp Asn Lys Pro Cys 
305                 310                 315                 320 


Gly Pro Gln Cys Tyr Gln His Leu Glu Gly Ala Lys Glu Phe Ala Ala 
                325                 330                 335     


Ala Leu Thr Ala Glu Arg Ile Lys Thr Pro Pro Lys Arg Pro Gly Gly 
            340                 345                 350         


Arg Arg Arg Gly Arg Leu Pro Asn Asn Ser Ser Arg Pro Ser Thr Pro 
        355                 360                 365             


Thr Ile Asn Val Leu Glu Ser Lys Asp Thr Asp Ser Asp Arg Glu Ala 
    370                 375                 380                 


Gly Thr Glu Thr Gly Gly Glu Asn Asn Asp Lys Glu Glu Glu Glu Lys 
385                 390                 395                 400 


Lys Asp Glu Thr Ser Ser Ser Ser Glu Ala Asn Ser Arg Cys Gln Thr 
                405                 410                 415     


Pro Ile Lys Met Lys Pro Asn Ile Glu Pro Pro Glu Asn Val Glu Trp 
            420                 425                 430         


Ser Gly Ala Glu Ala Ser Met Phe Arg Val Leu Ile Gly Thr Tyr Tyr 
        435                 440                 445             


Asp Asn Phe Cys Ala Ile Ala Arg Leu Ile Gly Thr Lys Thr Cys Arg 
    450                 455                 460                 


Gln Val Tyr Glu Phe Arg Val Lys Glu Ser Ser Ile Ile Ala Pro Ala 
465                 470                 475                 480 


Pro Ala Glu Asp Val Asp Thr Pro Pro Arg Lys Lys Lys Arg Lys His 
                485                 490                 495     


Arg Leu Trp Ala Ala His Cys Arg Lys Ile Gln Leu Lys Lys Asp Gly 
            500                 505                 510         


Ser Ser Asn His Val Tyr Asn Tyr Gln Pro Cys Asp His Pro Arg Gln 
        515                 520                 525             


Pro Cys Asp Ser Ser Cys Pro Cys Val Ile Ala Gln Asn Phe Cys Glu 
    530                 535                 540                 


Lys Phe Cys Gln Cys Ser Ser Glu Cys Gln Asn Arg Phe Pro Gly Cys 
545                 550                 555                 560 


Arg Cys Lys Ala Gln Cys Asn Thr Lys Gln Cys Pro Cys Tyr Leu Ala 
                565                 570                 575     


Val Arg Glu Cys Asp Pro Asp Leu Cys Leu Thr Cys Gly Ala Ala Asp 
            580                 585                 590         


His Trp Asp Ser Lys Asn Val Ser Cys Lys Asn Cys Ser Ile Gln Arg 
        595                 600                 605             


Gly Ser Lys Lys His Leu Leu Leu Ala Pro Ser Asp Val Ala Gly Trp 
    610                 615                 620                 


Gly Ile Phe Ile Lys Asp Pro Val Gln Lys Asn Glu Phe Ile Ser Glu 
625                 630                 635                 640 


Asn Cys Gly Glu Ile Ile Ser Gln Asp Glu Ala Asp Arg Arg Gly Lys 
                645                 650                 655     


Val Tyr Asp Lys Tyr Met Cys Ser Phe Leu Phe Asn Leu Asn Asn Asp 
            660                 665                 670         


Phe Val Val Asp Ala Thr Arg Lys Gly Asn Lys Ile Arg Phe Ala Asn 
        675                 680                 685             


His Ser Val Asn Pro Asn Cys Tyr Ala Lys Val Met Met Val Asn Gly 
    690                 695                 700                 


Asp His Arg Ile Gly Ile Phe Ala Lys Arg Ala Ile Gln Thr Gly Glu 
705                 710                 715                 720 


Glu Leu Phe Phe Asp Tyr Arg Tyr Ser Gln Ala Asp Ala Leu Lys Tyr 
                725                 730                 735     


Val Gly Ile Glu Arg Glu Met Glu Ile Pro 
            740                 745     


<210>  13
<211>  746
<212>  PRT
<213>  Homo sapiens

<400>  13

Met Gly Gln Thr Gly Lys Lys Ser Glu Lys Gly Pro Val Cys Trp Arg 
1               5                   10                  15      


Lys Arg Val Lys Ser Glu Tyr Met Arg Leu Arg Gln Leu Lys Arg Phe 
            20                  25                  30          


Arg Arg Ala Asp Glu Val Lys Ser Met Phe Ser Ser Asn Arg Gln Lys 
        35                  40                  45              


Ile Leu Glu Arg Thr Glu Ile Leu Asn Gln Glu Trp Lys Gln Arg Arg 
    50                  55                  60                  


Ile Gln Pro Val His Ile Leu Thr Ser Val Ser Ser Leu Arg Gly Thr 
65                  70                  75                  80  


Arg Glu Cys Ser Val Thr Ser Asp Leu Asp Phe Pro Thr Gln Val Ile 
                85                  90                  95      


Pro Leu Lys Thr Leu Asn Ala Val Ala Ser Val Pro Ile Met Tyr Ser 
            100                 105                 110         


Trp Ser Pro Leu Gln Gln Asn Phe Met Val Glu Asp Glu Thr Val Leu 
        115                 120                 125             


His Asn Ile Pro Tyr Met Gly Asp Glu Val Leu Asp Gln Asp Gly Thr 
    130                 135                 140                 


Phe Ile Glu Glu Leu Ile Lys Asn Tyr Asp Gly Lys Val His Gly Asp 
145                 150                 155                 160 


Arg Glu Cys Gly Phe Ile Asn Asp Glu Ile Phe Val Glu Leu Val Asn 
                165                 170                 175     


Ala Leu Gly Gln Tyr Asn Asp Asp Asp Asp Asp Asp Asp Gly Asp Asp 
            180                 185                 190         


Pro Glu Glu Arg Glu Glu Lys Gln Lys Asp Leu Glu Asp His Arg Asp 
        195                 200                 205             


Asp Lys Glu Ser Arg Pro Pro Arg Lys Phe Pro Ser Asp Lys Ile Phe 
    210                 215                 220                 


Glu Ala Ile Ser Ser Met Phe Pro Asp Lys Gly Thr Ala Glu Glu Leu 
225                 230                 235                 240 


Lys Glu Lys Tyr Lys Glu Leu Thr Glu Gln Gln Leu Pro Gly Ala Leu 
                245                 250                 255     


Pro Pro Glu Cys Thr Pro Asn Ile Asp Gly Pro Asn Ala Lys Ser Val 
            260                 265                 270         


Gln Arg Glu Gln Ser Leu His Ser Phe His Thr Leu Phe Cys Arg Arg 
        275                 280                 285             


Cys Phe Lys Tyr Asp Cys Phe Leu His Pro Phe His Ala Thr Pro Asn 
    290                 295                 300                 


Thr Tyr Lys Arg Lys Asn Thr Glu Thr Ala Leu Asp Asn Lys Pro Cys 
305                 310                 315                 320 


Gly Pro Gln Cys Tyr Gln His Leu Glu Gly Ala Lys Glu Phe Ala Ala 
                325                 330                 335     


Ala Leu Thr Ala Glu Arg Ile Lys Thr Pro Pro Lys Arg Pro Gly Gly 
            340                 345                 350         


Arg Arg Arg Gly Arg Leu Pro Asn Asn Ser Ser Arg Pro Ser Thr Pro 
        355                 360                 365             


Thr Ile Asn Val Leu Glu Ser Lys Asp Thr Asp Ser Asp Arg Glu Ala 
    370                 375                 380                 


Gly Thr Glu Thr Gly Gly Glu Asn Asn Asp Lys Glu Glu Glu Glu Lys 
385                 390                 395                 400 


Lys Asp Glu Thr Ser Ser Ser Ser Glu Ala Asn Ser Arg Cys Gln Thr 
                405                 410                 415     


Pro Ile Lys Met Lys Pro Asn Ile Glu Pro Pro Glu Asn Val Glu Trp 
            420                 425                 430         


Ser Gly Ala Glu Ala Ser Met Phe Arg Val Leu Ile Gly Thr Tyr Tyr 
        435                 440                 445             


Asp Asn Phe Cys Ala Ile Ala Arg Leu Ile Gly Thr Lys Thr Cys Arg 
    450                 455                 460                 


Gln Val Tyr Glu Phe Arg Val Lys Glu Ser Ser Ile Ile Ala Pro Ala 
465                 470                 475                 480 


Pro Ala Glu Asp Val Asp Thr Pro Pro Arg Lys Lys Lys Arg Lys His 
                485                 490                 495     


Arg Leu Trp Ala Ala His Cys Arg Lys Ile Gln Leu Lys Lys Asp Gly 
            500                 505                 510         


Ser Ser Asn His Val Tyr Asn Tyr Gln Pro Cys Asp His Pro Arg Gln 
        515                 520                 525             


Pro Cys Asp Ser Ser Cys Pro Cys Val Ile Ala Gln Asn Phe Cys Glu 
    530                 535                 540                 


Lys Phe Cys Gln Cys Ser Ser Glu Cys Gln Asn Arg Phe Pro Gly Cys 
545                 550                 555                 560 


Arg Cys Lys Ala Gln Cys Asn Thr Lys Gln Cys Pro Cys Tyr Leu Ala 
                565                 570                 575     


Val Arg Glu Cys Asp Pro Asp Leu Cys Leu Thr Cys Gly Ala Ala Asp 
            580                 585                 590         


His Trp Asp Ser Lys Asn Val Ser Cys Lys Asn Cys Ser Ile Gln Arg 
        595                 600                 605             


Gly Ser Lys Lys His Leu Leu Leu Ala Pro Ser Asp Val Ala Gly Trp 
    610                 615                 620                 


Gly Ile Phe Ile Lys Asp Pro Val Gln Lys Asn Glu Phe Ile Ser Glu 
625                 630                 635                 640 


Ser Cys Gly Glu Ile Ile Ser Gln Asp Glu Ala Asp Arg Arg Gly Lys 
                645                 650                 655     


Val Tyr Asp Lys Tyr Met Cys Ser Phe Leu Phe Asn Leu Asn Asn Asp 
            660                 665                 670         


Phe Val Val Asp Ala Thr Arg Lys Gly Asn Lys Ile Arg Phe Ala Asn 
        675                 680                 685             


His Ser Val Asn Pro Asn Cys Tyr Ala Lys Val Met Met Val Asn Gly 
    690                 695                 700                 


Asp His Arg Ile Gly Ile Phe Ala Lys Arg Ala Ile Gln Thr Gly Glu 
705                 710                 715                 720 


Glu Leu Phe Phe Asp Tyr Arg Tyr Ser Gln Ala Asp Ala Leu Lys Tyr 
                725                 730                 735     


Val Gly Ile Glu Arg Glu Met Glu Ile Pro 
            740                 745     


<210>  14
<211>  746
<212>  PRT
<213>  Homo sapiens

<400>  14

Met Gly Gln Thr Gly Lys Lys Ser Glu Lys Gly Pro Val Cys Trp Arg 
1               5                   10                  15      


Lys Arg Val Lys Ser Glu Tyr Met Arg Leu Arg Gln Leu Lys Arg Phe 
            20                  25                  30          


Arg Arg Ala Asp Glu Val Lys Ser Met Phe Ser Ser Asn Arg Gln Lys 
        35                  40                  45              


Ile Leu Glu Arg Thr Glu Ile Leu Asn Gln Glu Trp Lys Gln Arg Arg 
    50                  55                  60                  


Ile Gln Pro Val His Ile Leu Thr Ser Val Ser Ser Leu Arg Gly Thr 
65                  70                  75                  80  


Arg Glu Cys Ser Val Thr Ser Asp Leu Asp Phe Pro Thr Gln Val Ile 
                85                  90                  95      


Pro Leu Lys Thr Leu Asn Ala Val Ala Ser Val Pro Ile Met Tyr Ser 
            100                 105                 110         


Trp Ser Pro Leu Gln Gln Asn Phe Met Val Glu Asp Glu Thr Val Leu 
        115                 120                 125             


His Asn Ile Pro Tyr Met Gly Asp Glu Val Leu Asp Gln Asp Gly Thr 
    130                 135                 140                 


Phe Ile Glu Glu Leu Ile Lys Asn Tyr Asp Gly Lys Val His Gly Asp 
145                 150                 155                 160 


Arg Glu Cys Gly Phe Ile Asn Asp Glu Ile Phe Val Glu Leu Val Asn 
                165                 170                 175     


Ala Leu Gly Gln Tyr Asn Asp Asp Asp Asp Asp Asp Asp Gly Asp Asp 
            180                 185                 190         


Pro Glu Glu Arg Glu Glu Lys Gln Lys Asp Leu Glu Asp His Arg Asp 
        195                 200                 205             


Asp Lys Glu Ser Arg Pro Pro Arg Lys Phe Pro Ser Asp Lys Ile Phe 
    210                 215                 220                 


Glu Ala Ile Ser Ser Met Phe Pro Asp Lys Gly Thr Ala Glu Glu Leu 
225                 230                 235                 240 


Lys Glu Lys Tyr Lys Glu Leu Thr Glu Gln Gln Leu Pro Gly Ala Leu 
                245                 250                 255     


Pro Pro Glu Cys Thr Pro Asn Ile Asp Gly Pro Asn Ala Lys Ser Val 
            260                 265                 270         


Gln Arg Glu Gln Ser Leu His Ser Phe His Thr Leu Phe Cys Arg Arg 
        275                 280                 285             


Cys Phe Lys Tyr Asp Cys Phe Leu His Pro Phe His Ala Thr Pro Asn 
    290                 295                 300                 


Thr Tyr Lys Arg Lys Asn Thr Glu Thr Ala Leu Asp Asn Lys Pro Cys 
305                 310                 315                 320 


Gly Pro Gln Cys Tyr Gln His Leu Glu Gly Ala Lys Glu Phe Ala Ala 
                325                 330                 335     


Ala Leu Thr Ala Glu Arg Ile Lys Thr Pro Pro Lys Arg Pro Gly Gly 
            340                 345                 350         


Arg Arg Arg Gly Arg Leu Pro Asn Asn Ser Ser Arg Pro Ser Thr Pro 
        355                 360                 365             


Thr Ile Asn Val Leu Glu Ser Lys Asp Thr Asp Ser Asp Arg Glu Ala 
    370                 375                 380                 


Gly Thr Glu Thr Gly Gly Glu Asn Asn Asp Lys Glu Glu Glu Glu Lys 
385                 390                 395                 400 


Lys Asp Glu Thr Ser Ser Ser Ser Glu Ala Asn Ser Arg Cys Gln Thr 
                405                 410                 415     


Pro Ile Lys Met Lys Pro Asn Ile Glu Pro Pro Glu Asn Val Glu Trp 
            420                 425                 430         


Ser Gly Ala Glu Ala Ser Met Phe Arg Val Leu Ile Gly Thr Tyr Tyr 
        435                 440                 445             


Asp Asn Phe Cys Ala Ile Ala Arg Leu Ile Gly Thr Lys Thr Cys Arg 
    450                 455                 460                 


Gln Val Tyr Glu Phe Arg Val Lys Glu Ser Ser Ile Ile Ala Pro Ala 
465                 470                 475                 480 


Pro Ala Glu Asp Val Asp Thr Pro Pro Arg Lys Lys Lys Arg Lys His 
                485                 490                 495     


Arg Leu Trp Ala Ala His Cys Arg Lys Ile Gln Leu Lys Lys Asp Gly 
            500                 505                 510         


Ser Ser Asn His Val Tyr Asn Tyr Gln Pro Cys Asp His Pro Arg Gln 
        515                 520                 525             


Pro Cys Asp Ser Ser Cys Pro Cys Val Ile Ala Gln Asn Phe Cys Glu 
    530                 535                 540                 


Lys Phe Cys Gln Cys Ser Ser Glu Cys Gln Asn Arg Phe Pro Gly Cys 
545                 550                 555                 560 


Arg Cys Lys Ala Gln Cys Asn Thr Lys Gln Cys Pro Cys Tyr Leu Ala 
                565                 570                 575     


Val Arg Glu Cys Asp Pro Asp Leu Cys Leu Thr Cys Gly Ala Ala Asp 
            580                 585                 590         


His Trp Asp Ser Lys Asn Val Ser Cys Lys Asn Cys Ser Ile Gln Arg 
        595                 600                 605             


Gly Ser Lys Lys His Leu Leu Leu Ala Pro Ser Asp Val Ala Gly Trp 
    610                 615                 620                 


Gly Ile Phe Ile Lys Asp Pro Val Gln Lys Asn Glu Phe Ile Ser Glu 
625                 630                 635                 640 


Cys Cys Gly Glu Ile Ile Ser Gln Asp Glu Ala Asp Arg Arg Gly Lys 
                645                 650                 655     


Val Tyr Asp Lys Tyr Met Cys Ser Phe Leu Phe Asn Leu Asn Asn Asp 
            660                 665                 670         


Phe Val Val Asp Ala Thr Arg Lys Gly Asn Lys Ile Arg Phe Ala Asn 
        675                 680                 685             


His Ser Val Asn Pro Asn Cys Tyr Ala Lys Val Met Met Val Asn Gly 
    690                 695                 700                 


Asp His Arg Ile Gly Ile Phe Ala Lys Arg Ala Ile Gln Thr Gly Glu 
705                 710                 715                 720 


Glu Leu Phe Phe Asp Tyr Arg Tyr Ser Gln Ala Asp Ala Leu Lys Tyr 
                725                 730                 735     


Val Gly Ile Glu Arg Glu Met Glu Ile Pro 
            740                 745     


<210>  15
<211>  746
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (677)..(677)
<223>  Wherein X is preferably a glycine "G"

<400>  15

Met Gly Gln Thr Gly Lys Lys Ser Glu Lys Gly Pro Val Cys Trp Arg 
1               5                   10                  15      


Lys Arg Val Lys Ser Glu Tyr Met Arg Leu Arg Gln Leu Lys Arg Phe 
            20                  25                  30          


Arg Arg Ala Asp Glu Val Lys Ser Met Phe Ser Ser Asn Arg Gln Lys 
        35                  40                  45              


Ile Leu Glu Arg Thr Glu Ile Leu Asn Gln Glu Trp Lys Gln Arg Arg 
    50                  55                  60                  


Ile Gln Pro Val His Ile Leu Thr Ser Val Ser Ser Leu Arg Gly Thr 
65                  70                  75                  80  


Arg Glu Cys Ser Val Thr Ser Asp Leu Asp Phe Pro Thr Gln Val Ile 
                85                  90                  95      


Pro Leu Lys Thr Leu Asn Ala Val Ala Ser Val Pro Ile Met Tyr Ser 
            100                 105                 110         


Trp Ser Pro Leu Gln Gln Asn Phe Met Val Glu Asp Glu Thr Val Leu 
        115                 120                 125             


His Asn Ile Pro Tyr Met Gly Asp Glu Val Leu Asp Gln Asp Gly Thr 
    130                 135                 140                 


Phe Ile Glu Glu Leu Ile Lys Asn Tyr Asp Gly Lys Val His Gly Asp 
145                 150                 155                 160 


Arg Glu Cys Gly Phe Ile Asn Asp Glu Ile Phe Val Glu Leu Val Asn 
                165                 170                 175     


Ala Leu Gly Gln Tyr Asn Asp Asp Asp Asp Asp Asp Asp Gly Asp Asp 
            180                 185                 190         


Pro Glu Glu Arg Glu Glu Lys Gln Lys Asp Leu Glu Asp His Arg Asp 
        195                 200                 205             


Asp Lys Glu Ser Arg Pro Pro Arg Lys Phe Pro Ser Asp Lys Ile Phe 
    210                 215                 220                 


Glu Ala Ile Ser Ser Met Phe Pro Asp Lys Gly Thr Ala Glu Glu Leu 
225                 230                 235                 240 


Lys Glu Lys Tyr Lys Glu Leu Thr Glu Gln Gln Leu Pro Gly Ala Leu 
                245                 250                 255     


Pro Pro Glu Cys Thr Pro Asn Ile Asp Gly Pro Asn Ala Lys Ser Val 
            260                 265                 270         


Gln Arg Glu Gln Ser Leu His Ser Phe His Thr Leu Phe Cys Arg Arg 
        275                 280                 285             


Cys Phe Lys Tyr Asp Cys Phe Leu His Pro Phe His Ala Thr Pro Asn 
    290                 295                 300                 


Thr Tyr Lys Arg Lys Asn Thr Glu Thr Ala Leu Asp Asn Lys Pro Cys 
305                 310                 315                 320 


Gly Pro Gln Cys Tyr Gln His Leu Glu Gly Ala Lys Glu Phe Ala Ala 
                325                 330                 335     


Ala Leu Thr Ala Glu Arg Ile Lys Thr Pro Pro Lys Arg Pro Gly Gly 
            340                 345                 350         


Arg Arg Arg Gly Arg Leu Pro Asn Asn Ser Ser Arg Pro Ser Thr Pro 
        355                 360                 365             


Thr Ile Asn Val Leu Glu Ser Lys Asp Thr Asp Ser Asp Arg Glu Ala 
    370                 375                 380                 


Gly Thr Glu Thr Gly Gly Glu Asn Asn Asp Lys Glu Glu Glu Glu Lys 
385                 390                 395                 400 


Lys Asp Glu Thr Ser Ser Ser Ser Glu Ala Asn Ser Arg Cys Gln Thr 
                405                 410                 415     


Pro Ile Lys Met Lys Pro Asn Ile Glu Pro Pro Glu Asn Val Glu Trp 
            420                 425                 430         


Ser Gly Ala Glu Ala Ser Met Phe Arg Val Leu Ile Gly Thr Tyr Tyr 
        435                 440                 445             


Asp Asn Phe Cys Ala Ile Ala Arg Leu Ile Gly Thr Lys Thr Cys Arg 
    450                 455                 460                 


Gln Val Tyr Glu Phe Arg Val Lys Glu Ser Ser Ile Ile Ala Pro Ala 
465                 470                 475                 480 


Pro Ala Glu Asp Val Asp Thr Pro Pro Arg Lys Lys Lys Arg Lys His 
                485                 490                 495     


Arg Leu Trp Ala Ala His Cys Arg Lys Ile Gln Leu Lys Lys Asp Gly 
            500                 505                 510         


Ser Ser Asn His Val Tyr Asn Tyr Gln Pro Cys Asp His Pro Arg Gln 
        515                 520                 525             


Pro Cys Asp Ser Ser Cys Pro Cys Val Ile Ala Gln Asn Phe Cys Glu 
    530                 535                 540                 


Lys Phe Cys Gln Cys Ser Ser Glu Cys Gln Asn Arg Phe Pro Gly Cys 
545                 550                 555                 560 


Arg Cys Lys Ala Gln Cys Asn Thr Lys Gln Cys Pro Cys Tyr Leu Ala 
                565                 570                 575     


Val Arg Glu Cys Asp Pro Asp Leu Cys Leu Thr Cys Gly Ala Ala Asp 
            580                 585                 590         


His Trp Asp Ser Lys Asn Val Ser Cys Lys Asn Cys Ser Ile Gln Arg 
        595                 600                 605             


Gly Ser Lys Lys His Leu Leu Leu Ala Pro Ser Asp Val Ala Gly Trp 
    610                 615                 620                 


Gly Ile Phe Ile Lys Asp Pro Val Gln Lys Asn Glu Phe Ile Ser Glu 
625                 630                 635                 640 


Tyr Cys Gly Glu Ile Ile Ser Gln Asp Glu Ala Asp Arg Arg Gly Lys 
                645                 650                 655     


Val Tyr Asp Lys Tyr Met Cys Ser Phe Leu Phe Asn Leu Asn Asn Asp 
            660                 665                 670         


Phe Val Val Asp Xaa Thr Arg Lys Gly Asn Lys Ile Arg Phe Ala Asn 
        675                 680                 685             


His Ser Val Asn Pro Asn Cys Tyr Ala Lys Val Met Met Val Asn Gly 
    690                 695                 700                 


Asp His Arg Ile Gly Ile Phe Ala Lys Arg Ala Ile Gln Thr Gly Glu 
705                 710                 715                 720 


Glu Leu Phe Phe Asp Tyr Arg Tyr Ser Gln Ala Asp Ala Leu Lys Tyr 
                725                 730                 735     


Val Gly Ile Glu Arg Glu Met Glu Ile Pro 
            740                 745     


<210>  16
<211>  746
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (687)..(687)
<223>  Wherein X is preferably a valine "V"

<400>  16

Met Gly Gln Thr Gly Lys Lys Ser Glu Lys Gly Pro Val Cys Trp Arg 
1               5                   10                  15      


Lys Arg Val Lys Ser Glu Tyr Met Arg Leu Arg Gln Leu Lys Arg Phe 
            20                  25                  30          


Arg Arg Ala Asp Glu Val Lys Ser Met Phe Ser Ser Asn Arg Gln Lys 
        35                  40                  45              


Ile Leu Glu Arg Thr Glu Ile Leu Asn Gln Glu Trp Lys Gln Arg Arg 
    50                  55                  60                  


Ile Gln Pro Val His Ile Leu Thr Ser Val Ser Ser Leu Arg Gly Thr 
65                  70                  75                  80  


Arg Glu Cys Ser Val Thr Ser Asp Leu Asp Phe Pro Thr Gln Val Ile 
                85                  90                  95      


Pro Leu Lys Thr Leu Asn Ala Val Ala Ser Val Pro Ile Met Tyr Ser 
            100                 105                 110         


Trp Ser Pro Leu Gln Gln Asn Phe Met Val Glu Asp Glu Thr Val Leu 
        115                 120                 125             


His Asn Ile Pro Tyr Met Gly Asp Glu Val Leu Asp Gln Asp Gly Thr 
    130                 135                 140                 


Phe Ile Glu Glu Leu Ile Lys Asn Tyr Asp Gly Lys Val His Gly Asp 
145                 150                 155                 160 


Arg Glu Cys Gly Phe Ile Asn Asp Glu Ile Phe Val Glu Leu Val Asn 
                165                 170                 175     


Ala Leu Gly Gln Tyr Asn Asp Asp Asp Asp Asp Asp Asp Gly Asp Asp 
            180                 185                 190         


Pro Glu Glu Arg Glu Glu Lys Gln Lys Asp Leu Glu Asp His Arg Asp 
        195                 200                 205             


Asp Lys Glu Ser Arg Pro Pro Arg Lys Phe Pro Ser Asp Lys Ile Phe 
    210                 215                 220                 


Glu Ala Ile Ser Ser Met Phe Pro Asp Lys Gly Thr Ala Glu Glu Leu 
225                 230                 235                 240 


Lys Glu Lys Tyr Lys Glu Leu Thr Glu Gln Gln Leu Pro Gly Ala Leu 
                245                 250                 255     


Pro Pro Glu Cys Thr Pro Asn Ile Asp Gly Pro Asn Ala Lys Ser Val 
            260                 265                 270         


Gln Arg Glu Gln Ser Leu His Ser Phe His Thr Leu Phe Cys Arg Arg 
        275                 280                 285             


Cys Phe Lys Tyr Asp Cys Phe Leu His Pro Phe His Ala Thr Pro Asn 
    290                 295                 300                 


Thr Tyr Lys Arg Lys Asn Thr Glu Thr Ala Leu Asp Asn Lys Pro Cys 
305                 310                 315                 320 


Gly Pro Gln Cys Tyr Gln His Leu Glu Gly Ala Lys Glu Phe Ala Ala 
                325                 330                 335     


Ala Leu Thr Ala Glu Arg Ile Lys Thr Pro Pro Lys Arg Pro Gly Gly 
            340                 345                 350         


Arg Arg Arg Gly Arg Leu Pro Asn Asn Ser Ser Arg Pro Ser Thr Pro 
        355                 360                 365             


Thr Ile Asn Val Leu Glu Ser Lys Asp Thr Asp Ser Asp Arg Glu Ala 
    370                 375                 380                 


Gly Thr Glu Thr Gly Gly Glu Asn Asn Asp Lys Glu Glu Glu Glu Lys 
385                 390                 395                 400 


Lys Asp Glu Thr Ser Ser Ser Ser Glu Ala Asn Ser Arg Cys Gln Thr 
                405                 410                 415     


Pro Ile Lys Met Lys Pro Asn Ile Glu Pro Pro Glu Asn Val Glu Trp 
            420                 425                 430         


Ser Gly Ala Glu Ala Ser Met Phe Arg Val Leu Ile Gly Thr Tyr Tyr 
        435                 440                 445             


Asp Asn Phe Cys Ala Ile Ala Arg Leu Ile Gly Thr Lys Thr Cys Arg 
    450                 455                 460                 


Gln Val Tyr Glu Phe Arg Val Lys Glu Ser Ser Ile Ile Ala Pro Ala 
465                 470                 475                 480 


Pro Ala Glu Asp Val Asp Thr Pro Pro Arg Lys Lys Lys Arg Lys His 
                485                 490                 495     


Arg Leu Trp Ala Ala His Cys Arg Lys Ile Gln Leu Lys Lys Asp Gly 
            500                 505                 510         


Ser Ser Asn His Val Tyr Asn Tyr Gln Pro Cys Asp His Pro Arg Gln 
        515                 520                 525             


Pro Cys Asp Ser Ser Cys Pro Cys Val Ile Ala Gln Asn Phe Cys Glu 
    530                 535                 540                 


Lys Phe Cys Gln Cys Ser Ser Glu Cys Gln Asn Arg Phe Pro Gly Cys 
545                 550                 555                 560 


Arg Cys Lys Ala Gln Cys Asn Thr Lys Gln Cys Pro Cys Tyr Leu Ala 
                565                 570                 575     


Val Arg Glu Cys Asp Pro Asp Leu Cys Leu Thr Cys Gly Ala Ala Asp 
            580                 585                 590         


His Trp Asp Ser Lys Asn Val Ser Cys Lys Asn Cys Ser Ile Gln Arg 
        595                 600                 605             


Gly Ser Lys Lys His Leu Leu Leu Ala Pro Ser Asp Val Ala Gly Trp 
    610                 615                 620                 


Gly Ile Phe Ile Lys Asp Pro Val Gln Lys Asn Glu Phe Ile Ser Glu 
625                 630                 635                 640 


Tyr Cys Gly Glu Ile Ile Ser Gln Asp Glu Ala Asp Arg Arg Gly Lys 
                645                 650                 655     


Val Tyr Asp Lys Tyr Met Cys Ser Phe Leu Phe Asn Leu Asn Asn Asp 
            660                 665                 670         


Phe Val Val Asp Ala Thr Arg Lys Gly Asn Lys Ile Arg Phe Xaa Asn 
        675                 680                 685             


His Ser Val Asn Pro Asn Cys Tyr Ala Lys Val Met Met Val Asn Gly 
    690                 695                 700                 


Asp His Arg Ile Gly Ile Phe Ala Lys Arg Ala Ile Gln Thr Gly Glu 
705                 710                 715                 720 


Glu Leu Phe Phe Asp Tyr Arg Tyr Ser Gln Ala Asp Ala Leu Lys Tyr 
                725                 730                 735     


Val Gly Ile Glu Arg Glu Met Glu Ile Pro 
            740                 745     


<210>  17
<211>  746
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (685)..(685)
<223>  Wherein X is preferably a cysteine "C" or a histidine "H"

<400>  17

Met Gly Gln Thr Gly Lys Lys Ser Glu Lys Gly Pro Val Cys Trp Arg 
1               5                   10                  15      


Lys Arg Val Lys Ser Glu Tyr Met Arg Leu Arg Gln Leu Lys Arg Phe 
            20                  25                  30          


Arg Arg Ala Asp Glu Val Lys Ser Met Phe Ser Ser Asn Arg Gln Lys 
        35                  40                  45              


Ile Leu Glu Arg Thr Glu Ile Leu Asn Gln Glu Trp Lys Gln Arg Arg 
    50                  55                  60                  


Ile Gln Pro Val His Ile Leu Thr Ser Val Ser Ser Leu Arg Gly Thr 
65                  70                  75                  80  


Arg Glu Cys Ser Val Thr Ser Asp Leu Asp Phe Pro Thr Gln Val Ile 
                85                  90                  95      


Pro Leu Lys Thr Leu Asn Ala Val Ala Ser Val Pro Ile Met Tyr Ser 
            100                 105                 110         


Trp Ser Pro Leu Gln Gln Asn Phe Met Val Glu Asp Glu Thr Val Leu 
        115                 120                 125             


His Asn Ile Pro Tyr Met Gly Asp Glu Val Leu Asp Gln Asp Gly Thr 
    130                 135                 140                 


Phe Ile Glu Glu Leu Ile Lys Asn Tyr Asp Gly Lys Val His Gly Asp 
145                 150                 155                 160 


Arg Glu Cys Gly Phe Ile Asn Asp Glu Ile Phe Val Glu Leu Val Asn 
                165                 170                 175     


Ala Leu Gly Gln Tyr Asn Asp Asp Asp Asp Asp Asp Asp Gly Asp Asp 
            180                 185                 190         


Pro Glu Glu Arg Glu Glu Lys Gln Lys Asp Leu Glu Asp His Arg Asp 
        195                 200                 205             


Asp Lys Glu Ser Arg Pro Pro Arg Lys Phe Pro Ser Asp Lys Ile Phe 
    210                 215                 220                 


Glu Ala Ile Ser Ser Met Phe Pro Asp Lys Gly Thr Ala Glu Glu Leu 
225                 230                 235                 240 


Lys Glu Lys Tyr Lys Glu Leu Thr Glu Gln Gln Leu Pro Gly Ala Leu 
                245                 250                 255     


Pro Pro Glu Cys Thr Pro Asn Ile Asp Gly Pro Asn Ala Lys Ser Val 
            260                 265                 270         


Gln Arg Glu Gln Ser Leu His Ser Phe His Thr Leu Phe Cys Arg Arg 
        275                 280                 285             


Cys Phe Lys Tyr Asp Cys Phe Leu His Pro Phe His Ala Thr Pro Asn 
    290                 295                 300                 


Thr Tyr Lys Arg Lys Asn Thr Glu Thr Ala Leu Asp Asn Lys Pro Cys 
305                 310                 315                 320 


Gly Pro Gln Cys Tyr Gln His Leu Glu Gly Ala Lys Glu Phe Ala Ala 
                325                 330                 335     


Ala Leu Thr Ala Glu Arg Ile Lys Thr Pro Pro Lys Arg Pro Gly Gly 
            340                 345                 350         


Arg Arg Arg Gly Arg Leu Pro Asn Asn Ser Ser Arg Pro Ser Thr Pro 
        355                 360                 365             


Thr Ile Asn Val Leu Glu Ser Lys Asp Thr Asp Ser Asp Arg Glu Ala 
    370                 375                 380                 


Gly Thr Glu Thr Gly Gly Glu Asn Asn Asp Lys Glu Glu Glu Glu Lys 
385                 390                 395                 400 


Lys Asp Glu Thr Ser Ser Ser Ser Glu Ala Asn Ser Arg Cys Gln Thr 
                405                 410                 415     


Pro Ile Lys Met Lys Pro Asn Ile Glu Pro Pro Glu Asn Val Glu Trp 
            420                 425                 430         


Ser Gly Ala Glu Ala Ser Met Phe Arg Val Leu Ile Gly Thr Tyr Tyr 
        435                 440                 445             


Asp Asn Phe Cys Ala Ile Ala Arg Leu Ile Gly Thr Lys Thr Cys Arg 
    450                 455                 460                 


Gln Val Tyr Glu Phe Arg Val Lys Glu Ser Ser Ile Ile Ala Pro Ala 
465                 470                 475                 480 


Pro Ala Glu Asp Val Asp Thr Pro Pro Arg Lys Lys Lys Arg Lys His 
                485                 490                 495     


Arg Leu Trp Ala Ala His Cys Arg Lys Ile Gln Leu Lys Lys Asp Gly 
            500                 505                 510         


Ser Ser Asn His Val Tyr Asn Tyr Gln Pro Cys Asp His Pro Arg Gln 
        515                 520                 525             


Pro Cys Asp Ser Ser Cys Pro Cys Val Ile Ala Gln Asn Phe Cys Glu 
    530                 535                 540                 


Lys Phe Cys Gln Cys Ser Ser Glu Cys Gln Asn Arg Phe Pro Gly Cys 
545                 550                 555                 560 


Arg Cys Lys Ala Gln Cys Asn Thr Lys Gln Cys Pro Cys Tyr Leu Ala 
                565                 570                 575     


Val Arg Glu Cys Asp Pro Asp Leu Cys Leu Thr Cys Gly Ala Ala Asp 
            580                 585                 590         


His Trp Asp Ser Lys Asn Val Ser Cys Lys Asn Cys Ser Ile Gln Arg 
        595                 600                 605             


Gly Ser Lys Lys His Leu Leu Leu Ala Pro Ser Asp Val Ala Gly Trp 
    610                 615                 620                 


Gly Ile Phe Ile Lys Asp Pro Val Gln Lys Asn Glu Phe Ile Ser Glu 
625                 630                 635                 640 


Tyr Cys Gly Glu Ile Ile Ser Gln Asp Glu Ala Asp Arg Arg Gly Lys 
                645                 650                 655     


Val Tyr Asp Lys Tyr Met Cys Ser Phe Leu Phe Asn Leu Asn Asn Asp 
            660                 665                 670         


Phe Val Val Asp Ala Thr Arg Lys Gly Asn Lys Ile Xaa Phe Ala Asn 
        675                 680                 685             


His Ser Val Asn Pro Asn Cys Tyr Ala Lys Val Met Met Val Asn Gly 
    690                 695                 700                 


Asp His Arg Ile Gly Ile Phe Ala Lys Arg Ala Ile Gln Thr Gly Glu 
705                 710                 715                 720 


Glu Leu Phe Phe Asp Tyr Arg Tyr Ser Gln Ala Asp Ala Leu Lys Tyr 
                725                 730                 735     


Val Gly Ile Glu Arg Glu Met Glu Ile Pro 
            740                 745     


<210>  18
<211>  745
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (641)..(729)
<223>  Wherein "X" can be any amino acid except the corresponding wild 
       type residue.

<400>  18

Met Gly Gln Thr Gly Lys Lys Ser Glu Lys Gly Pro Val Cys Trp Arg 
1               5                   10                  15      


Lys Arg Val Lys Ser Glu Tyr Met Arg Leu Arg Gln Leu Lys Arg Phe 
            20                  25                  30          


Arg Arg Ala Asp Glu Val Lys Ser Met Phe Ser Ser Asn Arg Gln Lys 
        35                  40                  45              


Ile Leu Glu Arg Thr Glu Ile Leu Asn Gln Glu Trp Lys Gln Arg Arg 
    50                  55                  60                  


Ile Gln Pro Val His Ile Leu Thr Ser Val Ser Ser Leu Arg Gly Thr 
65                  70                  75                  80  


Arg Glu Cys Ser Val Thr Ser Asp Leu Asp Phe Pro Thr Gln Val Ile 
                85                  90                  95      


Pro Leu Lys Thr Leu Asn Ala Val Ala Ser Val Pro Ile Met Tyr Ser 
            100                 105                 110         


Trp Ser Pro Leu Gln Gln Asn Phe Met Val Glu Asp Glu Thr Val Leu 
        115                 120                 125             


His Asn Ile Pro Tyr Met Gly Asp Glu Val Leu Asp Gln Asp Gly Thr 
    130                 135                 140                 


Phe Ile Glu Glu Leu Ile Lys Asn Tyr Asp Gly Lys Val His Gly Asp 
145                 150                 155                 160 


Arg Glu Cys Gly Phe Ile Asn Asp Glu Ile Phe Val Glu Leu Val Asn 
                165                 170                 175     


Ala Leu Gly Gln Tyr Asn Asp Asp Asp Asp Asp Asp Asp Gly Asp Asp 
            180                 185                 190         


Pro Glu Glu Arg Glu Glu Lys Gln Lys Asp Leu Glu Asp His Arg Asp 
        195                 200                 205             


Asp Lys Glu Ser Arg Pro Pro Arg Lys Phe Pro Ser Asp Lys Ile Phe 
    210                 215                 220                 


Glu Ala Ile Ser Ser Met Phe Pro Asp Lys Gly Thr Ala Glu Glu Leu 
225                 230                 235                 240 


Lys Glu Lys Tyr Lys Glu Leu Thr Glu Gln Gln Leu Pro Gly Ala Leu 
                245                 250                 255     


Pro Pro Glu Cys Thr Pro Asn Ile Asp Gly Pro Asn Ala Lys Ser Val 
            260                 265                 270         


Gln Arg Glu Gln Ser Leu His Ser Phe His Thr Leu Phe Cys Arg Arg 
        275                 280                 285             


Cys Phe Lys Tyr Asp Cys Phe Leu His Pro Phe His Ala Thr Pro Asn 
    290                 295                 300                 


Thr Tyr Lys Arg Lys Asn Thr Glu Thr Ala Leu Asp Asn Lys Pro Cys 
305                 310                 315                 320 


Gly Pro Gln Cys Tyr Gln His Leu Glu Gly Ala Lys Glu Phe Ala Ala 
                325                 330                 335     


Ala Leu Thr Ala Glu Arg Ile Lys Thr Pro Pro Lys Arg Pro Gly Gly 
            340                 345                 350         


Arg Arg Arg Gly Arg Leu Pro Asn Asn Ser Ser Arg Pro Ser Thr Pro 
        355                 360                 365             


Thr Ile Asn Val Leu Glu Ser Lys Asp Thr Asp Ser Asp Arg Glu Ala 
    370                 375                 380                 


Gly Thr Glu Thr Gly Gly Glu Asn Asn Asp Lys Glu Glu Glu Glu Lys 
385                 390                 395                 400 


Lys Asp Glu Thr Ser Ser Ser Ser Glu Ala Asn Ser Arg Cys Gln Thr 
                405                 410                 415     


Pro Ile Lys Met Lys Pro Asn Ile Glu Pro Pro Glu Asn Val Glu Trp 
            420                 425                 430         


Ser Gly Ala Glu Ala Ser Met Phe Arg Val Leu Ile Gly Thr Tyr Tyr 
        435                 440                 445             


Asp Asn Phe Cys Ala Ile Ala Arg Leu Ile Gly Thr Lys Thr Cys Arg 
    450                 455                 460                 


Gln Val Tyr Glu Phe Arg Val Lys Glu Ser Ser Ile Ile Ala Pro Ala 
465                 470                 475                 480 


Pro Ala Glu Asp Val Asp Thr Pro Pro Arg Lys Lys Lys Arg Lys His 
                485                 490                 495     


Arg Leu Trp Ala Ala His Cys Arg Lys Ile Gln Leu Lys Lys Asp Gly 
            500                 505                 510         


Ser Ser Asn His Val Tyr Asn Tyr Gln Pro Cys Asp His Pro Arg Gln 
        515                 520                 525             


Pro Cys Asp Ser Ser Cys Pro Cys Val Ile Ala Gln Asn Phe Cys Glu 
    530                 535                 540                 


Lys Phe Cys Gln Cys Ser Ser Glu Cys Gln Asn Arg Phe Pro Gly Cys 
545                 550                 555                 560 


Arg Cys Lys Ala Gln Cys Asn Thr Lys Gln Cys Pro Cys Tyr Leu Ala 
                565                 570                 575     


Val Arg Glu Cys Asp Pro Asp Leu Cys Leu Thr Cys Gly Ala Ala Asp 
            580                 585                 590         


His Trp Asp Ser Lys Asn Val Ser Cys Lys Asn Cys Ser Ile Gln Arg 
        595                 600                 605             


Gly Ser Lys Lys His Leu Leu Leu Ala Pro Ser Asp Val Ala Gly Trp 
    610                 615                 620                 


Gly Ile Phe Ile Lys Asp Pro Val Gln Lys Asn Glu Phe Ile Ser Glu 
625                 630                 635                 640 


Xaa Cys Gly Glu Ile Ile Ser Gln Asp Glu Ala Asp Arg Arg Gly Lys 
                645                 650                 655     


Val Tyr Asp Lys Tyr Met Xaa Xaa Xaa Leu Xaa Asn Leu Asn Asn Asp 
            660                 665                 670         


Phe Xaa Xaa Asp Xaa Thr Arg Lys Gly Asn Lys Xaa Xaa Xaa Xaa His 
        675                 680                 685             


Ser Val Asn Pro Asn Cys Tyr Ala Lys Val Met Met Val Asn Gly Asp 
    690                 695                 700                 


His Arg Xaa Gly Ile Phe Ala Lys Arg Ala Ile Gln Thr Gly Glu Glu 
705                 710                 715                 720 


Leu Phe Xaa Asp Xaa Arg Tyr Ser Xaa Ala Asp Ala Leu Lys Tyr Val 
                725                 730                 735     


Gly Ile Glu Arg Glu Met Glu Ile Pro 
            740                 745 


<210>  19
<211>  8761
<212>  DNA
<213>  Homo sapiens

<400>  19
gccgaggagg aagaggttga tggcggcggc ggagctccga gagacctcgg ctgggcaggg       60

gccggccgtg gcgggccggg gactgcgcct ctagagccgc gagttctcgg gaattcgccg      120

cagcggacgc gctcggcgaa tttgtgctct tgtgccctcc tccgggcttg ggcccaggcc      180

cggcccctcg cacttgccct taccttttct atcgagtccg catccctctc cagccactgc      240

gacccggcga agagaaaaag gaacttcccc caccccctcg ggtgccgtcg gagcccccca      300

gcccacccct gggtgcggcg cggggacccc gggccgaaga agagatttcc tgaggattct      360

ggttttcctc gcttgtatct ccgaaagaat taaaaatggc cgagaatgtg gtggaaccgg      420

ggccgccttc agccaagcgg cctaaactct catctccggc cctctcggcg tccgccagcg      480

atggcacaga ttttggctct ctatttgact tggagcacga cttaccagat gaattaatca      540

actctacaga attgggacta accaatggtg gtgatattaa tcagcttcag acaagtcttg      600

gcatggtaca agatgcagct tctaaacata aacagctgtc agaattgctg cgatctggta      660

gttcccctaa cctcaatatg ggagttggtg gcccaggtca agtcatggcc agccaggccc      720

aacagagcag tcctggatta ggtttgataa atagcatggt caaaagccca atgacacagg      780

caggcttgac ttctcccaac atggggatgg gcactagtgg accaaatcag ggtcctacgc      840

agtcaacagg tatgatgaac agtccagtaa atcagcctgc catgggaatg aacacaggga      900

tgaatgcggg catgaatcct ggaatgttgg ctgcaggcaa tggacaaggg ataatgccta      960

atcaagtcat gaacggttca attggagcag gccgagggcg acagaatatg cagtacccaa     1020

acccaggcat gggaagtgct ggcaacttac tgactgagcc tcttcagcag ggctctcccc     1080

agatgggagg acaaacagga ttgagaggcc cccagcctct taagatggga atgatgaaca     1140

accccaatcc ttatggttca ccatatactc agaatcctgg acagcagatt ggagccagtg     1200

gccttggtct ccagattcag acaaaaactg tactatcaaa taacttatct ccatttgcta     1260

tggacaaaaa ggcagttcct ggtggaggaa tgcccaacat gggtcaacag ccagccccgc     1320

aggtccagca gccaggcctg gtgactccag ttgcccaagg gatgggttct ggagcacata     1380

cagctgatcc agagaagcgc aagctcatcc agcagcagct tgttctcctt ttgcatgctc     1440

acaagtgcca gcgccgggaa caggccaatg gggaagtgag gcagtgcaac cttccccact     1500

gtcgcacaat gaagaatgtc ctaaaccaca tgacacactg ccagtcaggc aagtcttgcc     1560

aagtggcaca ctgtgcatct tctcgacaaa tcatttcaca ctggaagaat tgtacaagac     1620

atgattgtcc tgtgtgtctc cccctcaaaa atgctggtga taagagaaat caacagccaa     1680

ttttgactgg agcacccgtt ggacttggaa atcctagctc tctaggggtg ggtcaacagt     1740

ctgcccccaa cctaagcact gttagtcaga ttgatcccag ctccatagaa agagcctatg     1800

cagctcttgg actaccctat caagtaaatc agatgccgac acaaccccag gtgcaagcaa     1860

agaaccagca gaatcagcag cctgggcagt ctccccaagg catgcggccc atgagcaaca     1920

tgagtgctag tcctatggga gtaaatggag gtgtaggagt tcaaacgccg agtcttcttt     1980

ctgactcaat gttgcattca gccataaatt ctcaaaaccc aatgatgagt gaaaatgcca     2040

gtgtgccctc cctgggtcct atgccaacag cagctcaacc atccactact ggaattcgga     2100

aacagtggca cgaagatatt actcaggatc ttcgaaatca tcttgttcac aaactcgtcc     2160

aagccatatt tcctacgccg gatcctgctg ctttaaaaga cagacggatg gaaaacctag     2220

ttgcatatgc tcggaaagtt gaaggggaca tgtatgaatc tgcaaacaat cgagcggaat     2280

actaccacct tctagctgag aaaatctata agatccagaa agaactagaa gaaaaacgaa     2340

ggaccagact acagaagcag aacatgctac caaatgctgc aggcatggtt ccagtttcca     2400

tgaatccagg gcctaacatg ggacagccgc aaccaggaat gacttctaat ggccctctac     2460

ctgacccaag tatgatccgt ggcagtgtgc caaaccagat gatgcctcga ataactccac     2520

aatctggttt gaatcaattt ggccagatga gcatggccca gccccctatt gtaccccggc     2580

aaacccctcc tcttcagcac catggacagt tggctcaacc tggagctctc aacccgccta     2640

tgggctatgg gcctcgtatg caacagcctt ccaaccaggg ccagttcctt cctcagactc     2700

agttcccatc acagggaatg aatgtaacaa atatcccttt ggctccgtcc agcggtcaag     2760

ctccagtgtc tcaagcacaa atgtctagtt cttcctgccc ggtgaactct cctataatgc     2820

ctccagggtc tcaggggagc cacattcact gtccccagct tcctcaacca gctcttcatc     2880

agaattcacc ctcgcctgta cctagtcgta cccccacccc tcaccatact cccccaagca     2940

taggggctca gcagccacca gcaacaacaa ttccagcccc tgttcctaca cctcctgcca     3000

tgccacctgg gccacagtcc caggctctac atccccctcc aaggcagaca cctacaccac     3060

caacaacaca acttccccaa caagtgcagc cttcacttcc tgctgcacct tctgctgacc     3120

agccccagca gcagcctcgc tcacagcaga gcacagcagc gtctgttcct accccaacag     3180

caccgctgct tcctccgcag cctgcaactc cactttccca gccagctgta agcattgaag     3240

gacaggtatc aaatcctcca tctactagta gcacagaagt gaattctcag gccattgctg     3300

agaagcagcc ttcccaggaa gtgaagatgg aggccaaaat ggaagtggat caaccagaac     3360

cagcagatac tcagccggag gatatttcag agtctaaagt ggaagactgt aaaatggaat     3420

ctaccgaaac agaagagaga agcactgagt taaaaactga aataaaagag gaggaagacc     3480

agccaagtac ttcagctacc cagtcatctc cggctccagg acagtcaaag aaaaagattt     3540

tcaaaccaga agaactacga caggcactga tgccaacttt ggaggcactt taccgtcagg     3600

atccagaatc ccttcccttt cgtcaacctg tggaccctca gcttttagga atccctgatt     3660

actttgatat tgtgaagagc cccatggatc tttctaccat taagaggaag ttagacactg     3720

gacagtatca ggagccctgg cagtatgtcg atgatatttg gcttatgttc aataatgcct     3780

ggttatataa ccggaaaaca tcacgggtat acaaatactg ctccaagctc tctgaggtct     3840

ttgaacaaga aattgaccca gtgatgcaaa gccttggata ctgttgtggc agaaagttgg     3900

agttctctcc acagacactg tgttgctacg gcaaacagtt gtgcacaata cctcgtgatg     3960

ccacttatta cagttaccag aacaggtatc atttctgtga gaagtgtttc aatgagatcc     4020

aaggggagag cgtttctttg ggggatgacc cttcccagcc tcaaactaca ataaataaag     4080

aacaattttc caagagaaaa aatgacacac tggatcctga actgtttgtt gaatgtacag     4140

agtgcggaag aaagatgcat cagatctgtg tccttcacca tgagatcatc tggcctgctg     4200

gattcgtctg tgatggctgt ttaaagaaaa gtgcacgaac taggaaagaa aataagtttt     4260

ctgctaaaag gttgccatct accagacttg gcacctttct agagaatcgt gtgaatgact     4320

ttctgaggcg acagaatcac cctgagtcag gagaggtcac tgttagagta gttcatgctt     4380

ctgacaaaac cgtggaagta aaaccaggca tgaaagcaag gtttgtggac agtggagaga     4440

tggcagaatc ctttccatac cgaaccaaag ccctctttgc ctttgaagaa attgatggtg     4500

ttgacctgtg cttctttggc atgcatgttc aagagtatgg ctctgactgc cctccaccca     4560

accagaggag agtatacata tcttacctcg atagtgttca tttcttccgt cctaaatgct     4620

tgaggactgc agtctatcat gaaatcctaa ttggatattt agaatatgtc aagaaattag     4680

gttacacaac agggcatatt tgggcatgtc caccaagtga gggagatgat tatatcttcc     4740

attgccatcc tcctgaccag aagataccca agcccaagcg actgcaggaa tggtacaaaa     4800

aaatgcttga caaggctgta tcagagcgta ttgtccatga ctacaaggat atttttaaac     4860

aagctactga agatagatta acaagtgcaa aggaattgcc ttatttcgag ggtgatttct     4920

ggcccaatgt tctggaagaa agcattaagg aactggaaca ggaggaagaa gagagaaaac     4980

gagaggaaaa caccagcaat gaaagcacag atgtgaccaa gggagacagc aaaaatgcta     5040

aaaagaagaa taataagaaa accagcaaaa ataagagcag cctgagtagg ggcaacaaga     5100

agaaacccgg gatgcccaat gtatctaacg acctctcaca gaaactatat gccaccatgg     5160

agaagcataa agaggtcttc tttgtgatcc gcctcattgc tggccctgct gccaactccc     5220

tgcctcccat tgttgatcct gatcctctca tcccctgcga tctgatggat ggtcgggatg     5280

cgtttctcac gctggcaagg gacaagcacc tggagttctc ttcactccga agagcccagt     5340

ggtccaccat gtgcatgctg gtggagctgc acacgcagag ccaggaccgc tttgtctaca     5400

cctgcaatga atgcaagcac catgtggaga cacgctggca ctgtactgtc tgtgaggatt     5460

atgacttgtg tatcacctgc tataacacta aaaaccatga ccacaaaatg gagaaactag     5520

gccttggctt agatgatgag agcaacaacc agcaggctgc agccacccag agcccaggcg     5580

attctcgccg cctgagtatc cagcgctgca tccagtctct ggtccatgct tgccagtgtc     5640

ggaatgccaa ttgctcactg ccatcctgcc agaagatgaa gcgggttgtg cagcatacca     5700

agggttgcaa acggaaaacc aatggcgggt gccccatctg caagcagctc attgccctct     5760

gctgctacca tgccaagcac tgccaggaga acaaatgccc ggtgccgttc tgcctaaaca     5820

tcaagcagaa gctccggcag caacagctgc agcaccgact acagcaggcc caaatgcttc     5880

gcaggaggat ggccagcatg cagcggactg gtgtggttgg gcagcaacag ggcctccctt     5940

cccccactcc tgccactcca acgacaccaa ctggccaaca gccaaccacc ccgcagacgc     6000

cccagcccac ttctcagcct cagcctaccc ctcccaatag catgccaccc tacttgccca     6060

ggactcaagc tgctggccct gtgtcccagg gtaaggcagc aggccaggtg acccctccaa     6120

cccctcctca gactgctcag ccaccccttc cagggccccc acctgcagca gtggaaatgg     6180

caatgcagat tcagagagca gcggagacgc agcgccagat ggcccacgtg caaatttttc     6240

aaaggccaat ccaacaccag atgcccccga tgactcccat ggcccccatg ggtatgaacc     6300

cacctcccat gaccagaggt cccagtgggc atttggagcc agggatggga ccgacaggga     6360

tgcagcaaca gccaccctgg agccaaggag gattgcctca gccccagcaa ctacagtctg     6420

ggatgccaag gccagccatg atgtcagtgg cccagcatgg tcaacctttg aacatggctc     6480

cacaaccagg attgggccag gtaggtatca gcccactcaa accaggcact gtgtctcaac     6540

aagccttaca aaaccttttg cggactctca ggtctcccag ctctcccctg cagcagcaac     6600

aggtgcttag tatccttcac gccaaccccc agctgttggc tgcattcatc aagcagcggg     6660

ctgccaagta tgccaactct aatccacaac ccatccctgg gcagcctggc atgccccagg     6720

ggcagccagg gctacagcca cctaccatgc caggtcagca gggggtccac tccaatccag     6780

ccatgcagaa catgaatcca atgcaggcgg gcgttcagag ggctggcctg ccccagcagc     6840

aaccacagca gcaactccag ccacccatgg gagggatgag cccccaggct cagcagatga     6900

acatgaacca caacaccatg ccttcacaat tccgagacat cttgagacga cagcaaatga     6960

tgcaacagca gcagcaacag ggagcagggc caggaatagg ccctggaatg gccaaccata     7020

accagttcca gcaaccccaa ggagttggct acccaccaca gcagcagcag cggatgcagc     7080

atcacatgca acagatgcaa caaggaaata tgggacagat aggccagctt ccccaggcct     7140

tgggagcaga ggcaggtgcc agtctacagg cctatcagca gcgactcctt cagcaacaga     7200

tggggtcccc tgttcagccc aaccccatga gcccccagca gcatatgctc ccaaatcagg     7260

cccagtcccc acacctacaa ggccagcaga tccctaattc tctctccaat caagtgcgct     7320

ctccccagcc tgtcccttct ccacggccac agtcccagcc cccccactcc agtccttccc     7380

caaggatgca gcctcagcct tctccacacc acgtttcccc acagacaagt tccccacatc     7440

ctggactggt agctgcccag gccaacccca tggaacaagg gcattttgcc agcccggacc     7500

agaattcaat gctttctcag cttgctagca atccaggcat ggcaaacctc catggtgcaa     7560

gcgccacgga cctgggactc agcaccgata actcagactt gaattcaaac ctctcacaga     7620

gtacactaga catacactag agacaccttg tagtattttg ggagcaaaaa aattattttc     7680

tcttaacaag actttttgta ctgaaaacaa tttttttgaa tctttcgtag cctaaaagac     7740

aattttcctt ggaacacata agaactgtgc agtagccgtt tgtggtttaa agcaaacatg     7800

caagatgaac ctgagggatg atagaataca aagaatatat ttttgttatg gctggttacc     7860

accagccttt cttccccttt gtgtgtgtgg ttcaagtgtg cactgggagg aggctgaggc     7920

ctgtgaagcc aaacaatatg ctcctgcctt gcacctccaa taggttttat tatttttttt     7980

aaattaatga acatatgtaa tattaatagt tattatttac tggtgcagat ggttgacatt     8040

tttccctatt ttcctcactt tatggaagag ttaaaacatt tctaaaccag aggacaaaag     8100

gggttaatgt tactttaaaa ttacattcta tatatatata aatatatata aatatatatt     8160

aaaataccag ttttttttct ctgggtgcaa agatgttcat tcttttaaaa aatgtttaaa     8220

aaaaaaaaaa aactgccttt cttcccctca agtcaacttt tgtgctccag aaaattttct     8280

attctgtaag tctgagcgta aaacttcaag tattaaaata atttgtacat gtagagagaa     8340

aaatgacttt ttcaaaaata tacaggggca gctgccaaat tgatgtatta tatattgtgg     8400

tttctgtttc ttgaaagaat ttttttcgtt atttttacat ctaacaaagt aaaaaaatta     8460

aaaagagggt aagaaacgat tccggtggga tgattttaac atgcaaaatg tccctggggg     8520

tttcttcttt gcttgctttc ttcctcctta ccctaccccc cactcacaca cacacacaca     8580

cacacacaca cacacacaca cacacacttt ctataaaact tgaaaatagc aaaaaccctc     8640

aactgttgta aatcatgcaa ttaaagttga ttacttataa atatgaactt tggatcactg     8700

tatagactgt taaatttgat ttcttattac ctattgttaa ataaactgtg tgagacagac     8760

a                                                                     8761


<210>  20
<211>  2414
<212>  PRT
<213>  Homo sapiens

<400>  20

Met Ala Glu Asn Val Val Glu Pro Gly Pro Pro Ser Ala Lys Arg Pro 
1               5                   10                  15      


Lys Leu Ser Ser Pro Ala Leu Ser Ala Ser Ala Ser Asp Gly Thr Asp 
            20                  25                  30          


Phe Gly Ser Leu Phe Asp Leu Glu His Asp Leu Pro Asp Glu Leu Ile 
        35                  40                  45              


Asn Ser Thr Glu Leu Gly Leu Thr Asn Gly Gly Asp Ile Asn Gln Leu 
    50                  55                  60                  


Gln Thr Ser Leu Gly Met Val Gln Asp Ala Ala Ser Lys His Lys Gln 
65                  70                  75                  80  


Leu Ser Glu Leu Leu Arg Ser Gly Ser Ser Pro Asn Leu Asn Met Gly 
                85                  90                  95      


Val Gly Gly Pro Gly Gln Val Met Ala Ser Gln Ala Gln Gln Ser Ser 
            100                 105                 110         


Pro Gly Leu Gly Leu Ile Asn Ser Met Val Lys Ser Pro Met Thr Gln 
        115                 120                 125             


Ala Gly Leu Thr Ser Pro Asn Met Gly Met Gly Thr Ser Gly Pro Asn 
    130                 135                 140                 


Gln Gly Pro Thr Gln Ser Thr Gly Met Met Asn Ser Pro Val Asn Gln 
145                 150                 155                 160 


Pro Ala Met Gly Met Asn Thr Gly Met Asn Ala Gly Met Asn Pro Gly 
                165                 170                 175     


Met Leu Ala Ala Gly Asn Gly Gln Gly Ile Met Pro Asn Gln Val Met 
            180                 185                 190         


Asn Gly Ser Ile Gly Ala Gly Arg Gly Arg Gln Asn Met Gln Tyr Pro 
        195                 200                 205             


Asn Pro Gly Met Gly Ser Ala Gly Asn Leu Leu Thr Glu Pro Leu Gln 
    210                 215                 220                 


Gln Gly Ser Pro Gln Met Gly Gly Gln Thr Gly Leu Arg Gly Pro Gln 
225                 230                 235                 240 


Pro Leu Lys Met Gly Met Met Asn Asn Pro Asn Pro Tyr Gly Ser Pro 
                245                 250                 255     


Tyr Thr Gln Asn Pro Gly Gln Gln Ile Gly Ala Ser Gly Leu Gly Leu 
            260                 265                 270         


Gln Ile Gln Thr Lys Thr Val Leu Ser Asn Asn Leu Ser Pro Phe Ala 
        275                 280                 285             


Met Asp Lys Lys Ala Val Pro Gly Gly Gly Met Pro Asn Met Gly Gln 
    290                 295                 300                 


Gln Pro Ala Pro Gln Val Gln Gln Pro Gly Leu Val Thr Pro Val Ala 
305                 310                 315                 320 


Gln Gly Met Gly Ser Gly Ala His Thr Ala Asp Pro Glu Lys Arg Lys 
                325                 330                 335     


Leu Ile Gln Gln Gln Leu Val Leu Leu Leu His Ala His Lys Cys Gln 
            340                 345                 350         


Arg Arg Glu Gln Ala Asn Gly Glu Val Arg Gln Cys Asn Leu Pro His 
        355                 360                 365             


Cys Arg Thr Met Lys Asn Val Leu Asn His Met Thr His Cys Gln Ser 
    370                 375                 380                 


Gly Lys Ser Cys Gln Val Ala His Cys Ala Ser Ser Arg Gln Ile Ile 
385                 390                 395                 400 


Ser His Trp Lys Asn Cys Thr Arg His Asp Cys Pro Val Cys Leu Pro 
                405                 410                 415     


Leu Lys Asn Ala Gly Asp Lys Arg Asn Gln Gln Pro Ile Leu Thr Gly 
            420                 425                 430         


Ala Pro Val Gly Leu Gly Asn Pro Ser Ser Leu Gly Val Gly Gln Gln 
        435                 440                 445             


Ser Ala Pro Asn Leu Ser Thr Val Ser Gln Ile Asp Pro Ser Ser Ile 
    450                 455                 460                 


Glu Arg Ala Tyr Ala Ala Leu Gly Leu Pro Tyr Gln Val Asn Gln Met 
465                 470                 475                 480 


Pro Thr Gln Pro Gln Val Gln Ala Lys Asn Gln Gln Asn Gln Gln Pro 
                485                 490                 495     


Gly Gln Ser Pro Gln Gly Met Arg Pro Met Ser Asn Met Ser Ala Ser 
            500                 505                 510         


Pro Met Gly Val Asn Gly Gly Val Gly Val Gln Thr Pro Ser Leu Leu 
        515                 520                 525             


Ser Asp Ser Met Leu His Ser Ala Ile Asn Ser Gln Asn Pro Met Met 
    530                 535                 540                 


Ser Glu Asn Ala Ser Val Pro Ser Leu Gly Pro Met Pro Thr Ala Ala 
545                 550                 555                 560 


Gln Pro Ser Thr Thr Gly Ile Arg Lys Gln Trp His Glu Asp Ile Thr 
                565                 570                 575     


Gln Asp Leu Arg Asn His Leu Val His Lys Leu Val Gln Ala Ile Phe 
            580                 585                 590         


Pro Thr Pro Asp Pro Ala Ala Leu Lys Asp Arg Arg Met Glu Asn Leu 
        595                 600                 605             


Val Ala Tyr Ala Arg Lys Val Glu Gly Asp Met Tyr Glu Ser Ala Asn 
    610                 615                 620                 


Asn Arg Ala Glu Tyr Tyr His Leu Leu Ala Glu Lys Ile Tyr Lys Ile 
625                 630                 635                 640 


Gln Lys Glu Leu Glu Glu Lys Arg Arg Thr Arg Leu Gln Lys Gln Asn 
                645                 650                 655     


Met Leu Pro Asn Ala Ala Gly Met Val Pro Val Ser Met Asn Pro Gly 
            660                 665                 670         


Pro Asn Met Gly Gln Pro Gln Pro Gly Met Thr Ser Asn Gly Pro Leu 
        675                 680                 685             


Pro Asp Pro Ser Met Ile Arg Gly Ser Val Pro Asn Gln Met Met Pro 
    690                 695                 700                 


Arg Ile Thr Pro Gln Ser Gly Leu Asn Gln Phe Gly Gln Met Ser Met 
705                 710                 715                 720 


Ala Gln Pro Pro Ile Val Pro Arg Gln Thr Pro Pro Leu Gln His His 
                725                 730                 735     


Gly Gln Leu Ala Gln Pro Gly Ala Leu Asn Pro Pro Met Gly Tyr Gly 
            740                 745                 750         


Pro Arg Met Gln Gln Pro Ser Asn Gln Gly Gln Phe Leu Pro Gln Thr 
        755                 760                 765             


Gln Phe Pro Ser Gln Gly Met Asn Val Thr Asn Ile Pro Leu Ala Pro 
    770                 775                 780                 


Ser Ser Gly Gln Ala Pro Val Ser Gln Ala Gln Met Ser Ser Ser Ser 
785                 790                 795                 800 


Cys Pro Val Asn Ser Pro Ile Met Pro Pro Gly Ser Gln Gly Ser His 
                805                 810                 815     


Ile His Cys Pro Gln Leu Pro Gln Pro Ala Leu His Gln Asn Ser Pro 
            820                 825                 830         


Ser Pro Val Pro Ser Arg Thr Pro Thr Pro His His Thr Pro Pro Ser 
        835                 840                 845             


Ile Gly Ala Gln Gln Pro Pro Ala Thr Thr Ile Pro Ala Pro Val Pro 
    850                 855                 860                 


Thr Pro Pro Ala Met Pro Pro Gly Pro Gln Ser Gln Ala Leu His Pro 
865                 870                 875                 880 


Pro Pro Arg Gln Thr Pro Thr Pro Pro Thr Thr Gln Leu Pro Gln Gln 
                885                 890                 895     


Val Gln Pro Ser Leu Pro Ala Ala Pro Ser Ala Asp Gln Pro Gln Gln 
            900                 905                 910         


Gln Pro Arg Ser Gln Gln Ser Thr Ala Ala Ser Val Pro Thr Pro Thr 
        915                 920                 925             


Ala Pro Leu Leu Pro Pro Gln Pro Ala Thr Pro Leu Ser Gln Pro Ala 
    930                 935                 940                 


Val Ser Ile Glu Gly Gln Val Ser Asn Pro Pro Ser Thr Ser Ser Thr 
945                 950                 955                 960 


Glu Val Asn Ser Gln Ala Ile Ala Glu Lys Gln Pro Ser Gln Glu Val 
                965                 970                 975     


Lys Met Glu Ala Lys Met Glu Val Asp Gln Pro Glu Pro Ala Asp Thr 
            980                 985                 990         


Gln Pro Glu Asp Ile Ser Glu Ser  Lys Val Glu Asp Cys  Lys Met Glu 
        995                 1000                 1005             


Ser Thr  Glu Thr Glu Glu Arg  Ser Thr Glu Leu Lys  Thr Glu Ile 
    1010                 1015                 1020             


Lys Glu  Glu Glu Asp Gln Pro  Ser Thr Ser Ala Thr  Gln Ser Ser 
    1025                 1030                 1035             


Pro Ala  Pro Gly Gln Ser Lys  Lys Lys Ile Phe Lys  Pro Glu Glu 
    1040                 1045                 1050             


Leu Arg  Gln Ala Leu Met Pro  Thr Leu Glu Ala Leu  Tyr Arg Gln 
    1055                 1060                 1065             


Asp Pro  Glu Ser Leu Pro Phe  Arg Gln Pro Val Asp  Pro Gln Leu 
    1070                 1075                 1080             


Leu Gly  Ile Pro Asp Tyr Phe  Asp Ile Val Lys Ser  Pro Met Asp 
    1085                 1090                 1095             


Leu Ser  Thr Ile Lys Arg Lys  Leu Asp Thr Gly Gln  Tyr Gln Glu 
    1100                 1105                 1110             


Pro Trp  Gln Tyr Val Asp Asp  Ile Trp Leu Met Phe  Asn Asn Ala 
    1115                 1120                 1125             


Trp Leu  Tyr Asn Arg Lys Thr  Ser Arg Val Tyr Lys  Tyr Cys Ser 
    1130                 1135                 1140             


Lys Leu  Ser Glu Val Phe Glu  Gln Glu Ile Asp Pro  Val Met Gln 
    1145                 1150                 1155             


Ser Leu  Gly Tyr Cys Cys Gly  Arg Lys Leu Glu Phe  Ser Pro Gln 
    1160                 1165                 1170             


Thr Leu  Cys Cys Tyr Gly Lys  Gln Leu Cys Thr Ile  Pro Arg Asp 
    1175                 1180                 1185             


Ala Thr  Tyr Tyr Ser Tyr Gln  Asn Arg Tyr His Phe  Cys Glu Lys 
    1190                 1195                 1200             


Cys Phe  Asn Glu Ile Gln Gly  Glu Ser Val Ser Leu  Gly Asp Asp 
    1205                 1210                 1215             


Pro Ser  Gln Pro Gln Thr Thr  Ile Asn Lys Glu Gln  Phe Ser Lys 
    1220                 1225                 1230             


Arg Lys  Asn Asp Thr Leu Asp  Pro Glu Leu Phe Val  Glu Cys Thr 
    1235                 1240                 1245             


Glu Cys  Gly Arg Lys Met His  Gln Ile Cys Val Leu  His His Glu 
    1250                 1255                 1260             


Ile Ile  Trp Pro Ala Gly Phe  Val Cys Asp Gly Cys  Leu Lys Lys 
    1265                 1270                 1275             


Ser Ala  Arg Thr Arg Lys Glu  Asn Lys Phe Ser Ala  Lys Arg Leu 
    1280                 1285                 1290             


Pro Ser  Thr Arg Leu Gly Thr  Phe Leu Glu Asn Arg  Val Asn Asp 
    1295                 1300                 1305             


Phe Leu  Arg Arg Gln Asn His  Pro Glu Ser Gly Glu  Val Thr Val 
    1310                 1315                 1320             


Arg Val  Val His Ala Ser Asp  Lys Thr Val Glu Val  Lys Pro Gly 
    1325                 1330                 1335             


Met Lys  Ala Arg Phe Val Asp  Ser Gly Glu Met Ala  Glu Ser Phe 
    1340                 1345                 1350             


Pro Tyr  Arg Thr Lys Ala Leu  Phe Ala Phe Glu Glu  Ile Asp Gly 
    1355                 1360                 1365             


Val Asp  Leu Cys Phe Phe Gly  Met His Val Gln Glu  Tyr Gly Ser 
    1370                 1375                 1380             


Asp Cys  Pro Pro Pro Asn Gln  Arg Arg Val Tyr Ile  Ser Tyr Leu 
    1385                 1390                 1395             


Asp Ser  Val His Phe Phe Arg  Pro Lys Cys Leu Arg  Thr Ala Val 
    1400                 1405                 1410             


Tyr His  Glu Ile Leu Ile Gly  Tyr Leu Glu Tyr Val  Lys Lys Leu 
    1415                 1420                 1425             


Gly Tyr  Thr Thr Gly His Ile  Trp Ala Cys Pro Pro  Ser Glu Gly 
    1430                 1435                 1440             


Asp Asp  Tyr Ile Phe His Cys  His Pro Pro Asp Gln  Lys Ile Pro 
    1445                 1450                 1455             


Lys Pro  Lys Arg Leu Gln Glu  Trp Tyr Lys Lys Met  Leu Asp Lys 
    1460                 1465                 1470             


Ala Val  Ser Glu Arg Ile Val  His Asp Tyr Lys Asp  Ile Phe Lys 
    1475                 1480                 1485             


Gln Ala  Thr Glu Asp Arg Leu  Thr Ser Ala Lys Glu  Leu Pro Tyr 
    1490                 1495                 1500             


Phe Glu  Gly Asp Phe Trp Pro  Asn Val Leu Glu Glu  Ser Ile Lys 
    1505                 1510                 1515             


Glu Leu  Glu Gln Glu Glu Glu  Glu Arg Lys Arg Glu  Glu Asn Thr 
    1520                 1525                 1530             


Ser Asn  Glu Ser Thr Asp Val  Thr Lys Gly Asp Ser  Lys Asn Ala 
    1535                 1540                 1545             


Lys Lys  Lys Asn Asn Lys Lys  Thr Ser Lys Asn Lys  Ser Ser Leu 
    1550                 1555                 1560             


Ser Arg  Gly Asn Lys Lys Lys  Pro Gly Met Pro Asn  Val Ser Asn 
    1565                 1570                 1575             


Asp Leu  Ser Gln Lys Leu Tyr  Ala Thr Met Glu Lys  His Lys Glu 
    1580                 1585                 1590             


Val Phe  Phe Val Ile Arg Leu  Ile Ala Gly Pro Ala  Ala Asn Ser 
    1595                 1600                 1605             


Leu Pro  Pro Ile Val Asp Pro  Asp Pro Leu Ile Pro  Cys Asp Leu 
    1610                 1615                 1620             


Met Asp  Gly Arg Asp Ala Phe  Leu Thr Leu Ala Arg  Asp Lys His 
    1625                 1630                 1635             


Leu Glu  Phe Ser Ser Leu Arg  Arg Ala Gln Trp Ser  Thr Met Cys 
    1640                 1645                 1650             


Met Leu  Val Glu Leu His Thr  Gln Ser Gln Asp Arg  Phe Val Tyr 
    1655                 1660                 1665             


Thr Cys  Asn Glu Cys Lys His  His Val Glu Thr Arg  Trp His Cys 
    1670                 1675                 1680             


Thr Val  Cys Glu Asp Tyr Asp  Leu Cys Ile Thr Cys  Tyr Asn Thr 
    1685                 1690                 1695             


Lys Asn  His Asp His Lys Met  Glu Lys Leu Gly Leu  Gly Leu Asp 
    1700                 1705                 1710             


Asp Glu  Ser Asn Asn Gln Gln  Ala Ala Ala Thr Gln  Ser Pro Gly 
    1715                 1720                 1725             


Asp Ser  Arg Arg Leu Ser Ile  Gln Arg Cys Ile Gln  Ser Leu Val 
    1730                 1735                 1740             


His Ala  Cys Gln Cys Arg Asn  Ala Asn Cys Ser Leu  Pro Ser Cys 
    1745                 1750                 1755             


Gln Lys  Met Lys Arg Val Val  Gln His Thr Lys Gly  Cys Lys Arg 
    1760                 1765                 1770             


Lys Thr  Asn Gly Gly Cys Pro  Ile Cys Lys Gln Leu  Ile Ala Leu 
    1775                 1780                 1785             


Cys Cys  Tyr His Ala Lys His  Cys Gln Glu Asn Lys  Cys Pro Val 
    1790                 1795                 1800             


Pro Phe  Cys Leu Asn Ile Lys  Gln Lys Leu Arg Gln  Gln Gln Leu 
    1805                 1810                 1815             


Gln His  Arg Leu Gln Gln Ala  Gln Met Leu Arg Arg  Arg Met Ala 
    1820                 1825                 1830             


Ser Met  Gln Arg Thr Gly Val  Val Gly Gln Gln Gln  Gly Leu Pro 
    1835                 1840                 1845             


Ser Pro  Thr Pro Ala Thr Pro  Thr Thr Pro Thr Gly  Gln Gln Pro 
    1850                 1855                 1860             


Thr Thr  Pro Gln Thr Pro Gln  Pro Thr Ser Gln Pro  Gln Pro Thr 
    1865                 1870                 1875             


Pro Pro  Asn Ser Met Pro Pro  Tyr Leu Pro Arg Thr  Gln Ala Ala 
    1880                 1885                 1890             


Gly Pro  Val Ser Gln Gly Lys  Ala Ala Gly Gln Val  Thr Pro Pro 
    1895                 1900                 1905             


Thr Pro  Pro Gln Thr Ala Gln  Pro Pro Leu Pro Gly  Pro Pro Pro 
    1910                 1915                 1920             


Ala Ala  Val Glu Met Ala Met  Gln Ile Gln Arg Ala  Ala Glu Thr 
    1925                 1930                 1935             


Gln Arg  Gln Met Ala His Val  Gln Ile Phe Gln Arg  Pro Ile Gln 
    1940                 1945                 1950             


His Gln  Met Pro Pro Met Thr  Pro Met Ala Pro Met  Gly Met Asn 
    1955                 1960                 1965             


Pro Pro  Pro Met Thr Arg Gly  Pro Ser Gly His Leu  Glu Pro Gly 
    1970                 1975                 1980             


Met Gly  Pro Thr Gly Met Gln  Gln Gln Pro Pro Trp  Ser Gln Gly 
    1985                 1990                 1995             


Gly Leu  Pro Gln Pro Gln Gln  Leu Gln Ser Gly Met  Pro Arg Pro 
    2000                 2005                 2010             


Ala Met  Met Ser Val Ala Gln  His Gly Gln Pro Leu  Asn Met Ala 
    2015                 2020                 2025             


Pro Gln  Pro Gly Leu Gly Gln  Val Gly Ile Ser Pro  Leu Lys Pro 
    2030                 2035                 2040             


Gly Thr  Val Ser Gln Gln Ala  Leu Gln Asn Leu Leu  Arg Thr Leu 
    2045                 2050                 2055             


Arg Ser  Pro Ser Ser Pro Leu  Gln Gln Gln Gln Val  Leu Ser Ile 
    2060                 2065                 2070             


Leu His  Ala Asn Pro Gln Leu  Leu Ala Ala Phe Ile  Lys Gln Arg 
    2075                 2080                 2085             


Ala Ala  Lys Tyr Ala Asn Ser  Asn Pro Gln Pro Ile  Pro Gly Gln 
    2090                 2095                 2100             


Pro Gly  Met Pro Gln Gly Gln  Pro Gly Leu Gln Pro  Pro Thr Met 
    2105                 2110                 2115             


Pro Gly  Gln Gln Gly Val His  Ser Asn Pro Ala Met  Gln Asn Met 
    2120                 2125                 2130             


Asn Pro  Met Gln Ala Gly Val  Gln Arg Ala Gly Leu  Pro Gln Gln 
    2135                 2140                 2145             


Gln Pro  Gln Gln Gln Leu Gln  Pro Pro Met Gly Gly  Met Ser Pro 
    2150                 2155                 2160             


Gln Ala  Gln Gln Met Asn Met  Asn His Asn Thr Met  Pro Ser Gln 
    2165                 2170                 2175             


Phe Arg  Asp Ile Leu Arg Arg  Gln Gln Met Met Gln  Gln Gln Gln 
    2180                 2185                 2190             


Gln Gln  Gly Ala Gly Pro Gly  Ile Gly Pro Gly Met  Ala Asn His 
    2195                 2200                 2205             


Asn Gln  Phe Gln Gln Pro Gln  Gly Val Gly Tyr Pro  Pro Gln Gln 
    2210                 2215                 2220             


Gln Gln  Arg Met Gln His His  Met Gln Gln Met Gln  Gln Gly Asn 
    2225                 2230                 2235             


Met Gly  Gln Ile Gly Gln Leu  Pro Gln Ala Leu Gly  Ala Glu Ala 
    2240                 2245                 2250             


Gly Ala  Ser Leu Gln Ala Tyr  Gln Gln Arg Leu Leu  Gln Gln Gln 
    2255                 2260                 2265             


Met Gly  Ser Pro Val Gln Pro  Asn Pro Met Ser Pro  Gln Gln His 
    2270                 2275                 2280             


Met Leu  Pro Asn Gln Ala Gln  Ser Pro His Leu Gln  Gly Gln Gln 
    2285                 2290                 2295             


Ile Pro  Asn Ser Leu Ser Asn  Gln Val Arg Ser Pro  Gln Pro Val 
    2300                 2305                 2310             


Pro Ser  Pro Arg Pro Gln Ser  Gln Pro Pro His Ser  Ser Pro Ser 
    2315                 2320                 2325             


Pro Arg  Met Gln Pro Gln Pro  Ser Pro His His Val  Ser Pro Gln 
    2330                 2335                 2340             


Thr Ser  Ser Pro His Pro Gly  Leu Val Ala Ala Gln  Ala Asn Pro 
    2345                 2350                 2355             


Met Glu  Gln Gly His Phe Ala  Ser Pro Asp Gln Asn  Ser Met Leu 
    2360                 2365                 2370             


Ser Gln  Leu Ala Ser Asn Pro  Gly Met Ala Asn Leu  His Gly Ala 
    2375                 2380                 2385             


Ser Ala  Thr Asp Leu Gly Leu  Ser Thr Asp Asn Ser  Asp Leu Asn 
    2390                 2395                 2400             


Ser Asn  Leu Ser Gln Ser Thr  Leu Asp Ile His 
    2405                 2410                 


<210>  21
<211>  695
<212>  PRT
<213>  Homo sapiens

<400>  21

Met Gly Gln Thr Gly Lys Lys Ser Glu Lys Gly Pro Val Cys Trp Arg 
1               5                   10                  15      


Lys Arg Val Lys Ser Glu Tyr Met Arg Leu Arg Gln Leu Lys Arg Phe 
            20                  25                  30          


Arg Arg Ala Asp Glu Val Lys Ser Met Phe Ser Ser Asn Arg Gln Lys 
        35                  40                  45              


Ile Leu Glu Arg Thr Glu Ile Leu Asn Gln Glu Trp Lys Gln Arg Arg 
    50                  55                  60                  


Ile Gln Pro Val His Ile Leu Thr Ser Cys Ser Val Thr Ser Asp Leu 
65                  70                  75                  80  


Asp Phe Pro Thr Gln Val Ile Pro Leu Lys Thr Leu Asn Ala Val Ala 
                85                  90                  95      


Ser Val Pro Ile Met Tyr Ser Trp Ser Pro Leu Gln Gln Asn Phe Met 
            100                 105                 110         


Val Glu Asp Glu Thr Val Leu His Asn Ile Pro Tyr Met Gly Asp Glu 
        115                 120                 125             


Val Leu Asp Gln Asp Gly Thr Phe Ile Glu Glu Leu Ile Lys Asn Tyr 
    130                 135                 140                 


Asp Gly Lys Val His Gly Asp Arg Glu Cys Gly Phe Ile Asn Asp Glu 
145                 150                 155                 160 


Ile Phe Val Glu Leu Val Asn Ala Leu Gly Gln Tyr Asn Asp Asp Asp 
                165                 170                 175     


Asp Asp Asp Asp Gly Asp Asp Pro Glu Glu Arg Glu Glu Lys Gln Lys 
            180                 185                 190         


Asp Leu Glu Asp His Arg Asp Asp Lys Glu Ser Arg Pro Pro Arg Lys 
        195                 200                 205             


Phe Pro Ser Asp Lys Ile Phe Glu Ala Ile Ser Ser Met Phe Pro Asp 
    210                 215                 220                 


Lys Gly Thr Ala Glu Glu Leu Lys Glu Lys Tyr Lys Glu Leu Thr Glu 
225                 230                 235                 240 


Gln Gln Leu Pro Gly Ala Leu Pro Pro Glu Cys Thr Pro Asn Ile Asp 
                245                 250                 255     


Gly Pro Asn Ala Lys Ser Val Gln Arg Glu Gln Ser Leu His Ser Phe 
            260                 265                 270         


His Thr Leu Phe Cys Arg Arg Cys Phe Lys Tyr Asp Cys Phe Leu His 
        275                 280                 285             


Pro Phe His Ala Thr Pro Asn Thr Tyr Lys Arg Lys Asn Thr Glu Thr 
    290                 295                 300                 


Ala Leu Asp Asn Lys Pro Cys Gly Pro Gln Cys Tyr Gln His Leu Glu 
305                 310                 315                 320 


Gly Ala Lys Glu Phe Ala Ala Ala Leu Thr Ala Glu Arg Ile Lys Thr 
                325                 330                 335     


Pro Pro Lys Arg Pro Gly Gly Arg Arg Arg Gly Arg Leu Pro Asn Asn 
            340                 345                 350         


Ser Ser Arg Pro Ser Thr Pro Thr Ile Asn Val Leu Glu Ser Lys Asp 
        355                 360                 365             


Thr Asp Ser Asp Arg Glu Ala Gly Thr Glu Thr Gly Gly Glu Asn Asn 
    370                 375                 380                 


Asp Lys Glu Glu Glu Glu Lys Lys Asp Glu Thr Ser Ser Ser Ser Glu 
385                 390                 395                 400 


Ala Asn Ser Arg Cys Gln Thr Pro Ile Lys Met Lys Pro Asn Ile Glu 
                405                 410                 415     


Pro Pro Glu Asn Val Glu Trp Ser Gly Ala Glu Ala Ser Met Phe Arg 
            420                 425                 430         


Val Leu Ile Gly Thr Tyr Tyr Asp Asn Phe Cys Ala Ile Ala Arg Leu 
        435                 440                 445             


Ile Gly Thr Lys Thr Cys Arg Gln Val Tyr Glu Phe Arg Val Lys Glu 
    450                 455                 460                 


Ser Ser Ile Ile Ala Pro Ala Pro Ala Glu Asp Val Asp Thr Pro Pro 
465                 470                 475                 480 


Arg Lys Lys Lys Arg Lys His Arg Leu Trp Ala Ala His Cys Arg Lys 
                485                 490                 495     


Ile Gln Leu Lys Lys Gly Gln Asn Arg Phe Pro Gly Cys Arg Cys Lys 
            500                 505                 510         


Ala Gln Cys Asn Thr Lys Gln Cys Pro Cys Tyr Leu Ala Val Arg Glu 
        515                 520                 525             


Cys Asp Pro Asp Leu Cys Leu Thr Cys Gly Ala Ala Asp His Trp Asp 
    530                 535                 540                 


Ser Lys Asn Val Ser Cys Lys Asn Cys Ser Ile Gln Arg Gly Ser Lys 
545                 550                 555                 560 


Lys His Leu Leu Leu Ala Pro Ser Asp Val Ala Gly Trp Gly Ile Phe 
                565                 570                 575     


Ile Lys Asp Pro Val Gln Lys Asn Glu Phe Ile Ser Glu Tyr Cys Gly 
            580                 585                 590         


Glu Ile Ile Ser Gln Asp Glu Ala Asp Arg Arg Gly Lys Val Tyr Asp 
        595                 600                 605             


Lys Tyr Met Cys Ser Phe Leu Phe Asn Leu Asn Asn Asp Phe Val Val 
    610                 615                 620                 


Asp Ala Thr Arg Lys Gly Asn Lys Ile Arg Phe Ala Asn His Ser Val 
625                 630                 635                 640 


Asn Pro Asn Cys Tyr Ala Lys Val Met Met Val Asn Gly Asp His Arg 
                645                 650                 655     


Ile Gly Ile Phe Ala Lys Arg Ala Ile Gln Thr Gly Glu Glu Leu Phe 
            660                 665                 670         


Phe Asp Tyr Arg Tyr Ser Gln Ala Asp Ala Leu Lys Tyr Val Gly Ile 
        675                 680                 685             


Glu Arg Glu Met Glu Ile Pro 
    690                 695 


<210>  22
<211>  2682
<212>  DNA
<213>  Homo sapiens

<400>  22
gacgacgttc gcggcgggga actcggagta gcttcgcctc tgacgtttcc ccacgacgca       60

ccccgaaatc cccctgagct ccggcggtcg cgggctgccc tcgccgcctg gtctggcttt      120

atgctaagtt tgagggaaga gtcgagctgc tctgctctct attgattgtg tttctggagg      180

gcgtcctgtt gaattcccac ttcattgtgt acatcccctt ccgttccccc caaaaatctg      240

tgccacaggg ttactttttg aaagcgggag gaatcgagaa gcacgatctt ttggaaaact      300

tggtgaacgc ctaaataatc atgggccaga ctgggaagaa atctgagaag ggaccagttt      360

gttggcggaa gcgtgtaaaa tcagagtaca tgcgactgag acagctcaag aggttcagac      420

gagctgatga agtaaagagt atgtttagtt ccaatcgtca gaaaattttg gaaagaacgg      480

aaatcttaaa ccaagaatgg aaacagcgaa ggatacagcc tgtgcacatc ctgacttctt      540

gttcggtgac cagtgacttg gattttccaa cacaagtcat cccattaaag actctgaatg      600

cagttgcttc agtacccata atgtattctt ggtctcccct acagcagaat tttatggtgg      660

aagatgaaac tgttttacat aacattcctt atatgggaga tgaagtttta gatcaggatg      720

gtactttcat tgaagaacta ataaaaaatt atgatgggaa agtacacggg gatagagaat      780

gtgggtttat aaatgatgaa atttttgtgg agttggtgaa tgcccttggt caatataatg      840

atgatgacga tgatgatgat ggagacgatc ctgaagaaag agaagaaaag cagaaagatc      900

tggaggatca ccgagatgat aaagaaagcc gcccacctcg gaaatttcct tctgataaaa      960

tttttgaagc catttcctca atgtttccag ataagggcac agcagaagaa ctaaaggaaa     1020

aatataaaga actcaccgaa cagcagctcc caggcgcact tcctcctgaa tgtaccccca     1080

acatagatgg accaaatgct aaatctgttc agagagagca aagcttacac tcctttcata     1140

cgcttttctg taggcgatgt tttaaatatg actgcttcct acatcctttt catgcaacac     1200

ccaacactta taagcggaag aacacagaaa cagctctaga caacaaacct tgtggaccac     1260

agtgttacca gcatttggag ggagcaaagg agtttgctgc tgctctcacc gctgagcgga     1320

taaagacccc accaaaacgt ccaggaggcc gcagaagagg acggcttccc aataacagta     1380

gcaggcccag cacccccacc attaatgtgc tggaatcaaa ggatacagac agtgataggg     1440

aagcagggac tgaaacgggg ggagagaaca atgataaaga agaagaagag aagaaagatg     1500

aaacttcgag ctcctctgaa gcaaattctc ggtgtcaaac accaataaag atgaagccaa     1560

atattgaacc tcctgagaat gtggagtgga gtggtgctga agcctcaatg tttagagtcc     1620

tcattggcac ttactatgac aatttctgtg ccattgctag gttaattggg accaaaacat     1680

gtagacaggt gtatgagttt agagtcaaag aatctagcat catagctcca gctcccgctg     1740

aggatgtgga tactcctcca aggaaaaaga agaggaaaca ccggttgtgg gctgcacact     1800

gcagaaagat acagctgaaa aagggtcaaa accgctttcc gggatgccgc tgcaaagcac     1860

agtgcaacac caagcagtgc ccgtgctacc tggctgtccg agagtgtgac cctgacctct     1920

gtcttacttg tggagccgct gaccattggg acagtaaaaa tgtgtcctgc aagaactgca     1980

gtattcagcg gggctccaaa aagcatctat tgctggcacc atctgacgtg gcaggctggg     2040

ggatttttat caaagatcct gtgcagaaaa atgaattcat ctcagaatac tgtggagaga     2100

ttatttctca agatgaagct gacagaagag ggaaagtgta tgataaatac atgtgcagct     2160

ttctgttcaa cttgaacaat gattttgtgg tggatgcaac ccgcaagggt aacaaaattc     2220

gttttgcaaa tcattcggta aatccaaact gctatgcaaa agttatgatg gttaacggtg     2280

atcacaggat aggtattttt gccaagagag ccatccagac tggcgaagag ctgttttttg     2340

attacagata cagccaggct gatgccctga agtatgtcgg catcgaaaga gaaatggaaa     2400

tcccttgaca tctgctacct cctcccccct cctctgaaac agctgcctta gcttcaggaa     2460

cctcgagtac tgtgggcaat ttagaaaaag aacatgcagt ttgaaattct gaatttgcaa     2520

agtactgtaa gaataattta tagtaatgag tttaaaaatc aactttttat tgccttctca     2580

ccagctgcaa agtgttttgt accagtgaat ttttgcaata atgcagtatg gtacattttt     2640

caactttgaa taaagaatac ttgaacttgt ccttgttgaa tc                        2682


<210>  23
<211>  10197
<212>  DNA
<213>  Homo sapiens

<400>  23
ctgcggggcg ctgttgctgt ggctgagatt tggccgccgc ctcccccacc cggcctgcgc       60

cctccctctc cctcggcgcc cgcccgcccg ctcgcggccc gcgctcgctc ctctccctcg      120

cagccggcag ggcccccgac ccccgtccgg gccctcgccg gcccggccgc ccgtgcccgg      180

ggctgttttc gcgagcaggt gaaaatggct gagaacttgc tggacggacc gcccaacccc      240

aaaagagcca aactcagctc gcccggtttc tcggcgaatg acagcacaga ttttggatca      300

ttgtttgact tggaaaatga tcttcctgat gagctgatac ccaatggagg agaattaggc      360

cttttaaaca gtgggaacct tgttccagat gctgcttcca aacataaaca actgtcggag      420

cttctacgag gaggcagcgg ctctagtatc aacccaggaa taggaaatgt gagcgccagc      480

agccccgtgc agcagggcct gggtggccag gctcaagggc agccgaacag tgctaacatg      540

gccagcctca gtgccatggg caagagccct ctgagccagg gagattcttc agcccccagc      600

ctgcctaaac aggcagccag cacctctggg cccacccccg ctgcctccca agcactgaat      660

ccgcaagcac aaaagcaagt ggggctggcg actagcagcc ctgccacgtc acagactgga      720

cctggtatct gcatgaatgc taactttaac cagacccacc caggcctcct caatagtaac      780

tctggccata gcttaattaa tcaggcttca caagggcagg cgcaagtcat gaatggatct      840

cttggggctg ctggcagagg aaggggagct ggaatgccgt accctactcc agccatgcag      900

ggcgcctcga gcagcgtgct ggctgagacc ctaacgcagg tttccccgca aatgactggt      960

cacgcgggac tgaacaccgc acaggcagga ggcatggcca agatgggaat aactgggaac     1020

acaagtccat ttggacagcc ctttagtcaa gctggagggc agccaatggg agccactgga     1080

gtgaaccccc agttagccag caaacagagc atggtcaaca gtttgcccac cttccctaca     1140

gatatcaaga atacttcagt caccaacgtg ccaaatatgt ctcagatgca aacatcagtg     1200

ggaattgtac ccacacaagc aattgcaaca ggccccactg cagatcctga aaaacgcaaa     1260

ctgatacagc agcagctggt tctactgctt catgctcata agtgtcagag acgagagcaa     1320

gcaaacggag aggttcgggc ctgctcgctc ccgcattgtc gaaccatgaa aaacgttttg     1380

aatcacatga cgcattgtca ggctgggaaa gcctgccaag ttgcccattg tgcatcttca     1440

cgacaaatca tctctcattg gaagaactgc acacgacatg actgtcctgt ttgcctccct     1500

ttgaaaaatg ccagtgacaa gcgaaaccaa caaaccatcc tggggtctcc agctagtgga     1560

attcaaaaca caattggttc tgttggcaca gggcaacaga atgccacttc tttaagtaac     1620

ccaaatccca tagaccccag ctccatgcag cgagcctatg ctgctctcgg actcccctac     1680

atgaaccagc cccagacgca gctgcagcct caggttcctg gccagcaacc agcacagcct     1740

caaacccacc agcagatgag gactctcaac cccctgggaa ataatccaat gaacattcca     1800

gcaggaggaa taacaacaga tcagcagccc ccaaacttga tttcagaatc agctcttccg     1860

acttccctgg gggccacaaa cccactgatg aacgatggct ccaactctgg taacattgga     1920

accctcagca ctataccaac agcagctcct ccttctagca ccggtgtaag gaaaggctgg     1980

cacgaacatg tcactcagga cctgcggagc catctagtgc ataaactcgt ccaagccatc     2040

ttcccaacac ctgatcccgc agctctaaag gatcgccgca tggaaaacct ggtagcctat     2100

gctaagaaag tggaagggga catgtacgag tctgccaaca gcagggatga atattatcac     2160

ttattagcag agaaaatcta caagatacaa aaagaactag aagaaaaacg gaggtcgcgt     2220

ttacataaac aaggcatctt ggggaaccag ccagccttac cagccccggg ggctcagccc     2280

cctgtgattc cacaggcaca acctgtgaga cctccaaatg gacccctgtc cctgccagtg     2340

aatcgcatgc aagtttctca agggatgaat tcatttaacc ccatgtcctt ggggaacgtc     2400

cagttgccac aagcacccat gggacctcgt gcagcctccc caatgaacca ctctgtccag     2460

atgaacagca tgggctcagt gccagggatg gccatttctc cttcccgaat gcctcagcct     2520

ccgaacatga tgggtgcaca caccaacaac atgatggccc aggcgcccgc tcagagccag     2580

tttctgccac agaaccagtt cccgtcatcc agcggggcga tgagtgtggg catggggcag     2640

ccgccagccc aaacaggcgt gtcacaggga caggtgcctg gtgctgctct tcctaaccct     2700

ctcaacatgc tggggcctca ggccagccag ctaccttgcc ctccagtgac acagtcacca     2760

ctgcacccaa caccgcctcc tgcttccacg gctgctggca tgccatctct ccagcacacg     2820

acaccacctg ggatgactcc tccccagcca gcagctccca ctcagccatc aactcctgtg     2880

tcgtcttccg ggcagactcc caccccgact cctggctcag tgcccagtgc tacccaaacc     2940

cagagcaccc ctacagtcca ggcagcagcc caggcccagg tgaccccgca gcctcaaacc     3000

ccagttcagc ccccgtctgt ggctacccct cagtcatcgc agcaacagcc gacgcctgtg     3060

cacgcccagc ctcctggcac accgctttcc caggcagcag ccagcattga taacagagtc     3120

cctaccccct cctcggtggc cagcgcagaa accaattccc agcagccagg acctgacgta     3180

cctgtgctgg aaatgaagac ggagacccaa gcagaggaca ctgagcccga tcctggtgaa     3240

tccaaagggg agcccaggtc tgagatgatg gaggaggatt tgcaaggagc ttcccaagtt     3300

aaagaagaaa cagacatagc agagcagaaa tcagaaccaa tggaagtgga tgaaaagaaa     3360

cctgaagtga aagtagaagt taaagaggaa gaagagagta gcagtaacgg cacagcctct     3420

cagtcaacat ctccttcgca gccgcgcaaa aaaatcttta aaccagagga gttacgccag     3480

gccctcatgc caaccctaga agcactgtat cgacaggacc cagagtcatt acctttccgg     3540

cagcctgtag atccccagct cctcggaatt ccagactatt ttgacatcgt aaagaatccc     3600

atggacctct ccaccatcaa gcggaagctg gacacagggc aataccaaga gccctggcag     3660

tacgtggacg acgtctggct catgttcaac aatgcctggc tctataatcg caagacatcc     3720

cgagtctata agttttgcag taagcttgca gaggtctttg agcaggaaat tgaccctgtc     3780

atgcagtccc ttggatattg ctgtggacgc aagtatgagt tttccccaca gactttgtgc     3840

tgctatggga agcagctgtg taccattcct cgcgatgctg cctactacag ctatcagaat     3900

aggtatcatt tctgtgagaa gtgtttcaca gagatccagg gcgagaatgt gaccctgggt     3960

gacgaccctt cacagcccca gacgacaatt tcaaaggatc agtttgaaaa gaagaaaaat     4020

gataccttag accccgaacc tttcgttgat tgcaaggagt gtggccggaa gatgcatcag     4080

atttgcgttc tgcactatga catcatttgg ccttcaggtt ttgtgtgcga caactgcttg     4140

aagaaaactg gcagacctcg aaaagaaaac aaattcagtg ctaagaggct gcagaccaca     4200

agactgggaa accacttgga agaccgagtg aacaaatttt tgcggcgcca gaatcaccct     4260

gaagccgggg aggtttttgt ccgagtggtg gccagctcag acaagacggt ggaggtcaag     4320

cccgggatga agtcacggtt tgtggattct ggggaaatgt ctgaatcttt cccatatcga     4380

accaaagctc tgtttgcttt tgaggaaatt gacggcgtgg atgtctgctt ttttggaatg     4440

cacgtccaag aatacggctc tgattgcccc cctccaaaca cgaggcgtgt gtacatttct     4500

tatctggata gtattcattt cttccggcca cgttgcctcc gcacagccgt ttaccatgag     4560

atccttattg gatatttaga gtatgtgaag aaattagggt atgtgacagg gcacatctgg     4620

gcctgtcctc caagtgaagg agatgattac atcttccatt gccacccacc tgatcaaaaa     4680

atacccaagc caaaacgact gcaggagtgg tacaaaaaga tgctggacaa ggcgtttgca     4740

gagcggatca tccatgacta caaggatatt ttcaaacaag caactgaaga caggctcacc     4800

agtgccaagg aactgcccta ttttgaaggt gatttctggc ccaatgtgtt agaagagagc     4860

attaaggaac tagaacaaga agaagaggag aggaaaaagg aagagagcac tgcagccagt     4920

gaaaccactg agggcagtca gggcgacagc aagaatgcca agaagaagaa caacaagaaa     4980

accaacaaga acaaaagcag catcagccgc gccaacaaga agaagcccag catgcccaac     5040

gtgtccaatg acctgtccca gaagctgtat gccaccatgg agaagcacaa ggaggtcttc     5100

ttcgtgatcc acctgcacgc tgggcctgtc atcaacaccc tgccccccat cgtcgacccc     5160

gaccccctgc tcagctgtga cctcatggat gggcgcgacg ccttcctcac cctcgccaga     5220

gacaagcact gggagttctc ctccttgcgc cgctccaagt ggtccacgct ctgcatgctg     5280

gtggagctgc acacccaggg ccaggaccgc tttgtctaca cctgcaacga gtgcaagcac     5340

cacgtggaga cgcgctggca ctgcactgtg tgcgaggact acgacctctg catcaactgc     5400

tataacacga agagccatgc ccataagatg gtgaagtggg ggctgggcct ggatgacgag     5460

ggcagcagcc agggcgagcc acagtcaaag agcccccagg agtcacgccg gctgagcatc     5520

cagcgctgca tccagtcgct ggtgcacgcg tgccagtgcc gcaacgccaa ctgctcgctg     5580

ccatcctgcc agaagatgaa gcgggtggtg cagcacacca agggctgcaa acgcaagacc     5640

aacgggggct gcccggtgtg caagcagctc atcgccctct gctgctacca cgccaagcac     5700

tgccaagaaa acaaatgccc cgtgcccttc tgcctcaaca tcaaacacaa gctccgccag     5760

cagcagatcc agcaccgcct gcagcaggcc cagctcatgc gccggcggat ggccaccatg     5820

aacacccgca acgtgcctca gcagagtctg ccttctccta cctcagcacc gcccgggacc     5880

cccacacagc agcccagcac accccagacg ccgcagcccc ctgcccagcc ccaaccctca     5940

cccgtgagca tgtcaccagc tggcttcccc agcgtggccc ggactcagcc ccccaccacg     6000

gtgtccacag ggaagcctac cagccaggtg ccggcccccc cacccccggc ccagccccct     6060

cctgcagcgg tggaagcggc tcggcagatc gagcgtgagg cccagcagca gcagcacctg     6120

taccgggtga acatcaacaa cagcatgccc ccaggacgca cgggcatggg gaccccgggg     6180

agccagatgg cccccgtgag cctgaatgtg ccccgaccca accaggtgag cgggcccgtc     6240

atgcccagca tgcctcccgg gcagtggcag caggcgcccc ttccccagca gcagcccatg     6300

ccaggcttgc ccaggcctgt gatatccatg caggcccagg cggccgtggc tgggccccgg     6360

atgcccagcg tgcagccacc caggagcatc tcacccagcg ctctgcaaga cctgctgcgg     6420

accctgaagt cgcccagctc ccctcagcag caacagcagg tgctgaacat tctcaaatca     6480

aacccgcagc taatggcagc tttcatcaaa cagcgcacag ccaagtacgt ggccaatcag     6540

cccggcatgc agccccagcc tggcctccag tcccagcccg gcatgcaacc ccagcctggc     6600

atgcaccagc agcccagcct gcagaacctg aatgccatgc aggctggcgt gccgcggccc     6660

ggtgtgcctc cacagcagca ggcgatggga ggcctgaacc cccagggcca ggccttgaac     6720

atcatgaacc caggacacaa ccccaacatg gcgagtatga atccacagta ccgagaaatg     6780

ttacggaggc agctgctgca gcagcagcag caacagcagc agcaacaaca gcagcaacag     6840

cagcagcagc aagggagtgc cggcatggct gggggcatgg cggggcacgg ccagttccag     6900

cagcctcaag gacccggagg ctacccaccg gccatgcagc agcagcagcg catgcagcag     6960

catctccccc tccagggcag ctccatgggc cagatggcgg ctcagatggg acagcttggc     7020

cagatggggc agccggggct gggggcagac agcaccccca acatccagca agccctgcag     7080

cagcggattc tgcagcaaca gcagatgaag cagcagattg ggtccccagg ccagccgaac     7140

cccatgagcc cccagcaaca catgctctca ggacagccac aggcctcgca tctccctggc     7200

cagcagatcg ccacgtccct tagtaaccag gtgcggtctc cagcccctgt ccagtctcca     7260

cggccccagt cccagcctcc acattccagc ccgtcaccac ggatacagcc ccagccttcg     7320

ccacaccacg tctcacccca gactggttcc ccccaccccg gactcgcagt caccatggcc     7380

agctccatag atcagggaca cttggggaac cccgaacaga gtgcaatgct cccccagctg     7440

aacaccccca gcaggagtgc gctgtccagc gaactgtccc tggtcgggga caccacgggg     7500

gacacgctag agaagtttgt ggagggcttg tagcattgtg agagcatcac cttttccctt     7560

tcatgttctt ggaccttttg tactgaaaat ccaggcatct aggttctttt tattcctaga     7620

tggaactgcg acttccgagc catggaaggg tggattgatg tttaaagaaa caatacaaag     7680

aatatatttt tttgttaaaa accagttgat ttaaatatct ggtctctctc tttggttttt     7740

ttttggcggg ggggtggggg gggttctttt ttttccgttt tgtttttgtt tggggggagg     7800

ggggttttgt ttggattctt tttgtcgtca ttgctggtga ctcatgcctt tttttaacgg     7860

gaaaaacaag ttcattatat tcatattttt tatttgtatt ttcaagactt taaacattta     7920

tgtttaaaag taagaagaaa aataatattc agaactgatt cctgaaataa tgcaagctta     7980

taatgtatcc cgataacttt gtgatgtttc gggaagattt ttttctatag tgaactctgt     8040

gggcgtctcc cagtattacc ctggatgata ggaattgact ccggcgtgca cacacgtaca     8100

cacccacaca catctatcta tacataatgg ctgaagccaa acttgtcttg cagatgtaga     8160

aattgttgct ttgtttctct gataaaactg gttttagaca aaaaataggg atgatcactc     8220

ttagaccatg ctaatgttac tagagaagaa gccttctttt ctttcttcta tgtgaaactt     8280

gaaatgagga aaagcaattc tagtgtaaat catgcaagcg ctctaattcc tataaatacg     8340

aaactcgaga agattcaatc actgtataga atggtaaaat accaactcat ttcttatatc     8400

atattgttaa ataaactgtg tgcaacagac aaaaagggtg gtccttcttg aattcatgta     8460

catggtatta acacttagtg ttcggggttt tttgttatga aaatgctgtt ttcaacattg     8520

tatttggact atgcatgtgt tttttcccca ttgtatataa agtaccgctt aaaattgata     8580

taaattactg aggtttttaa catgtattct gttctttaag atccctgtaa gaatgtttaa     8640

ggtttttatt tatttatata tattttttga gtctgttctt tgtaagacat ggttctggtt     8700

gttcgctcat agcggagagg ctggggctgc ggttgtggtt gtggcggcgt gggtggtggc     8760

tgggaactgt ggcccaggct tagcggccgc ccggaggctt ttcttcccgg agactgaggt     8820

gggcgactga ggtgggcggc tcagcgttgg ccccacacat tcgaggctca caggtgattg     8880

tcgctcacac agttagggtc gtcagttggt ctgaaactgc atttggccca ctcctccatc     8940

ctccctgtcc gtcgtagctg ccacccccag aggcggcgct tcttcccgtg ttcaggcggc     9000

tccccccccc cgtacacgac tcccagaatc tgaggcagag agtgctccag gctcgcgagg     9060

tgctttctga cttcccccca aatcctgccg ctgccgcgca gcatgtcccg tgtggcgttt     9120

gaggaaatgc tgagggacag acaccttgga gcaccagctc cggtccctgt tacagtgaga     9180

aaggtccccc acttcggggg atacttgcac ttagccacat ggtcctgcct cccttggagt     9240

ccagttccag gctcccttac tgagtgggtg agacaagttc acaaaaaccg taaaactgag     9300

aggaggacca tgggcagggg agctgaagtt catcccctaa gtctaccacc cccagcaccc     9360

agagaaccca ctttatccct agtcccccaa caaaggctgg tctaggtggg ggtgatggta     9420

attttagaaa tcacgcccca aatagcttcc gtttgggccc ttacattcac agataggttt     9480

taaatagctg aatacttggt ttgggaatct gaattcgagg aacctttcta agaagttgga     9540

aaggtccgat ctagttttag cacagagctt tgaaccttga gttataaaat gcagaataat     9600

tcaagtaaaa ataagaccac catctggcac ccctgaccag cccccattca ccccatccca     9660

ggaggggaag cacaggccgg gcctccggtg gagattgctg ccactgctcg gcctgctggg     9720

ttcttaacct ccagtgtcct cttcatcttt tccacccgta gggaaacctt gagccatgtg     9780

ttcaaacaag aagtggggct agagcccgag agcagcagct ctaagcccac actcagaaag     9840

tggcgccctc ctggttgtgc agccttttaa tgtgggcagt ggaggggcct ctgtttcagg     9900

ttatcctgga attcaaaacg ttatgtacca acctcatcct ctttggagtc tgcatcctgt     9960

gcaaccgtct tgggcaatcc agatgtcgaa ggatgtgacc gagagcatgg tctgtggatg    10020

ctaaccctaa gtttgtcgta aggaaatttc tgtaagaaac ctggaaagcc ccaacgctgt    10080

gtctcatgct gtatacttaa gaggagaaga aaaagtccta tatttgtgat caaaaagagg    10140

aaacttgaaa tgtgatggtg tttataataa aagatggtaa aactacttgg attcaaa       10197


<210>  24
<211>  2442
<212>  PRT
<213>  Homo sapiens

<400>  24

Met Ala Glu Asn Leu Leu Asp Gly Pro Pro Asn Pro Lys Arg Ala Lys 
1               5                   10                  15      


Leu Ser Ser Pro Gly Phe Ser Ala Asn Asp Ser Thr Asp Phe Gly Ser 
            20                  25                  30          


Leu Phe Asp Leu Glu Asn Asp Leu Pro Asp Glu Leu Ile Pro Asn Gly 
        35                  40                  45              


Gly Glu Leu Gly Leu Leu Asn Ser Gly Asn Leu Val Pro Asp Ala Ala 
    50                  55                  60                  


Ser Lys His Lys Gln Leu Ser Glu Leu Leu Arg Gly Gly Ser Gly Ser 
65                  70                  75                  80  


Ser Ile Asn Pro Gly Ile Gly Asn Val Ser Ala Ser Ser Pro Val Gln 
                85                  90                  95      


Gln Gly Leu Gly Gly Gln Ala Gln Gly Gln Pro Asn Ser Ala Asn Met 
            100                 105                 110         


Ala Ser Leu Ser Ala Met Gly Lys Ser Pro Leu Ser Gln Gly Asp Ser 
        115                 120                 125             


Ser Ala Pro Ser Leu Pro Lys Gln Ala Ala Ser Thr Ser Gly Pro Thr 
    130                 135                 140                 


Pro Ala Ala Ser Gln Ala Leu Asn Pro Gln Ala Gln Lys Gln Val Gly 
145                 150                 155                 160 


Leu Ala Thr Ser Ser Pro Ala Thr Ser Gln Thr Gly Pro Gly Ile Cys 
                165                 170                 175     


Met Asn Ala Asn Phe Asn Gln Thr His Pro Gly Leu Leu Asn Ser Asn 
            180                 185                 190         


Ser Gly His Ser Leu Ile Asn Gln Ala Ser Gln Gly Gln Ala Gln Val 
        195                 200                 205             


Met Asn Gly Ser Leu Gly Ala Ala Gly Arg Gly Arg Gly Ala Gly Met 
    210                 215                 220                 


Pro Tyr Pro Thr Pro Ala Met Gln Gly Ala Ser Ser Ser Val Leu Ala 
225                 230                 235                 240 


Glu Thr Leu Thr Gln Val Ser Pro Gln Met Thr Gly His Ala Gly Leu 
                245                 250                 255     


Asn Thr Ala Gln Ala Gly Gly Met Ala Lys Met Gly Ile Thr Gly Asn 
            260                 265                 270         


Thr Ser Pro Phe Gly Gln Pro Phe Ser Gln Ala Gly Gly Gln Pro Met 
        275                 280                 285             


Gly Ala Thr Gly Val Asn Pro Gln Leu Ala Ser Lys Gln Ser Met Val 
    290                 295                 300                 


Asn Ser Leu Pro Thr Phe Pro Thr Asp Ile Lys Asn Thr Ser Val Thr 
305                 310                 315                 320 


Asn Val Pro Asn Met Ser Gln Met Gln Thr Ser Val Gly Ile Val Pro 
                325                 330                 335     


Thr Gln Ala Ile Ala Thr Gly Pro Thr Ala Asp Pro Glu Lys Arg Lys 
            340                 345                 350         


Leu Ile Gln Gln Gln Leu Val Leu Leu Leu His Ala His Lys Cys Gln 
        355                 360                 365             


Arg Arg Glu Gln Ala Asn Gly Glu Val Arg Ala Cys Ser Leu Pro His 
    370                 375                 380                 


Cys Arg Thr Met Lys Asn Val Leu Asn His Met Thr His Cys Gln Ala 
385                 390                 395                 400 


Gly Lys Ala Cys Gln Val Ala His Cys Ala Ser Ser Arg Gln Ile Ile 
                405                 410                 415     


Ser His Trp Lys Asn Cys Thr Arg His Asp Cys Pro Val Cys Leu Pro 
            420                 425                 430         


Leu Lys Asn Ala Ser Asp Lys Arg Asn Gln Gln Thr Ile Leu Gly Ser 
        435                 440                 445             


Pro Ala Ser Gly Ile Gln Asn Thr Ile Gly Ser Val Gly Thr Gly Gln 
    450                 455                 460                 


Gln Asn Ala Thr Ser Leu Ser Asn Pro Asn Pro Ile Asp Pro Ser Ser 
465                 470                 475                 480 


Met Gln Arg Ala Tyr Ala Ala Leu Gly Leu Pro Tyr Met Asn Gln Pro 
                485                 490                 495     


Gln Thr Gln Leu Gln Pro Gln Val Pro Gly Gln Gln Pro Ala Gln Pro 
            500                 505                 510         


Gln Thr His Gln Gln Met Arg Thr Leu Asn Pro Leu Gly Asn Asn Pro 
        515                 520                 525             


Met Asn Ile Pro Ala Gly Gly Ile Thr Thr Asp Gln Gln Pro Pro Asn 
    530                 535                 540                 


Leu Ile Ser Glu Ser Ala Leu Pro Thr Ser Leu Gly Ala Thr Asn Pro 
545                 550                 555                 560 


Leu Met Asn Asp Gly Ser Asn Ser Gly Asn Ile Gly Thr Leu Ser Thr 
                565                 570                 575     


Ile Pro Thr Ala Ala Pro Pro Ser Ser Thr Gly Val Arg Lys Gly Trp 
            580                 585                 590         


His Glu His Val Thr Gln Asp Leu Arg Ser His Leu Val His Lys Leu 
        595                 600                 605             


Val Gln Ala Ile Phe Pro Thr Pro Asp Pro Ala Ala Leu Lys Asp Arg 
    610                 615                 620                 


Arg Met Glu Asn Leu Val Ala Tyr Ala Lys Lys Val Glu Gly Asp Met 
625                 630                 635                 640 


Tyr Glu Ser Ala Asn Ser Arg Asp Glu Tyr Tyr His Leu Leu Ala Glu 
                645                 650                 655     


Lys Ile Tyr Lys Ile Gln Lys Glu Leu Glu Glu Lys Arg Arg Ser Arg 
            660                 665                 670         


Leu His Lys Gln Gly Ile Leu Gly Asn Gln Pro Ala Leu Pro Ala Pro 
        675                 680                 685             


Gly Ala Gln Pro Pro Val Ile Pro Gln Ala Gln Pro Val Arg Pro Pro 
    690                 695                 700                 


Asn Gly Pro Leu Ser Leu Pro Val Asn Arg Met Gln Val Ser Gln Gly 
705                 710                 715                 720 


Met Asn Ser Phe Asn Pro Met Ser Leu Gly Asn Val Gln Leu Pro Gln 
                725                 730                 735     


Ala Pro Met Gly Pro Arg Ala Ala Ser Pro Met Asn His Ser Val Gln 
            740                 745                 750         


Met Asn Ser Met Gly Ser Val Pro Gly Met Ala Ile Ser Pro Ser Arg 
        755                 760                 765             


Met Pro Gln Pro Pro Asn Met Met Gly Ala His Thr Asn Asn Met Met 
    770                 775                 780                 


Ala Gln Ala Pro Ala Gln Ser Gln Phe Leu Pro Gln Asn Gln Phe Pro 
785                 790                 795                 800 


Ser Ser Ser Gly Ala Met Ser Val Gly Met Gly Gln Pro Pro Ala Gln 
                805                 810                 815     


Thr Gly Val Ser Gln Gly Gln Val Pro Gly Ala Ala Leu Pro Asn Pro 
            820                 825                 830         


Leu Asn Met Leu Gly Pro Gln Ala Ser Gln Leu Pro Cys Pro Pro Val 
        835                 840                 845             


Thr Gln Ser Pro Leu His Pro Thr Pro Pro Pro Ala Ser Thr Ala Ala 
    850                 855                 860                 


Gly Met Pro Ser Leu Gln His Thr Thr Pro Pro Gly Met Thr Pro Pro 
865                 870                 875                 880 


Gln Pro Ala Ala Pro Thr Gln Pro Ser Thr Pro Val Ser Ser Ser Gly 
                885                 890                 895     


Gln Thr Pro Thr Pro Thr Pro Gly Ser Val Pro Ser Ala Thr Gln Thr 
            900                 905                 910         


Gln Ser Thr Pro Thr Val Gln Ala Ala Ala Gln Ala Gln Val Thr Pro 
        915                 920                 925             


Gln Pro Gln Thr Pro Val Gln Pro Pro Ser Val Ala Thr Pro Gln Ser 
    930                 935                 940                 


Ser Gln Gln Gln Pro Thr Pro Val His Ala Gln Pro Pro Gly Thr Pro 
945                 950                 955                 960 


Leu Ser Gln Ala Ala Ala Ser Ile Asp Asn Arg Val Pro Thr Pro Ser 
                965                 970                 975     


Ser Val Ala Ser Ala Glu Thr Asn Ser Gln Gln Pro Gly Pro Asp Val 
            980                 985                 990         


Pro Val Leu Glu Met Lys Thr Glu  Thr Gln Ala Glu Asp  Thr Glu Pro 
        995                 1000                 1005             


Asp Pro  Gly Glu Ser Lys Gly  Glu Pro Arg Ser Glu  Met Met Glu 
    1010                 1015                 1020             


Glu Asp  Leu Gln Gly Ala Ser  Gln Val Lys Glu Glu  Thr Asp Ile 
    1025                 1030                 1035             


Ala Glu  Gln Lys Ser Glu Pro  Met Glu Val Asp Glu  Lys Lys Pro 
    1040                 1045                 1050             


Glu Val  Lys Val Glu Val Lys  Glu Glu Glu Glu Ser  Ser Ser Asn 
    1055                 1060                 1065             


Gly Thr  Ala Ser Gln Ser Thr  Ser Pro Ser Gln Pro  Arg Lys Lys 
    1070                 1075                 1080             


Ile Phe  Lys Pro Glu Glu Leu  Arg Gln Ala Leu Met  Pro Thr Leu 
    1085                 1090                 1095             


Glu Ala  Leu Tyr Arg Gln Asp  Pro Glu Ser Leu Pro  Phe Arg Gln 
    1100                 1105                 1110             


Pro Val  Asp Pro Gln Leu Leu  Gly Ile Pro Asp Tyr  Phe Asp Ile 
    1115                 1120                 1125             


Val Lys  Asn Pro Met Asp Leu  Ser Thr Ile Lys Arg  Lys Leu Asp 
    1130                 1135                 1140             


Thr Gly  Gln Tyr Gln Glu Pro  Trp Gln Tyr Val Asp  Asp Val Trp 
    1145                 1150                 1155             


Leu Met  Phe Asn Asn Ala Trp  Leu Tyr Asn Arg Lys  Thr Ser Arg 
    1160                 1165                 1170             


Val Tyr  Lys Phe Cys Ser Lys  Leu Ala Glu Val Phe  Glu Gln Glu 
    1175                 1180                 1185             


Ile Asp  Pro Val Met Gln Ser  Leu Gly Tyr Cys Cys  Gly Arg Lys 
    1190                 1195                 1200             


Tyr Glu  Phe Ser Pro Gln Thr  Leu Cys Cys Tyr Gly  Lys Gln Leu 
    1205                 1210                 1215             


Cys Thr  Ile Pro Arg Asp Ala  Ala Tyr Tyr Ser Tyr  Gln Asn Arg 
    1220                 1225                 1230             


Tyr His  Phe Cys Glu Lys Cys  Phe Thr Glu Ile Gln  Gly Glu Asn 
    1235                 1240                 1245             


Val Thr  Leu Gly Asp Asp Pro  Ser Gln Pro Gln Thr  Thr Ile Ser 
    1250                 1255                 1260             


Lys Asp  Gln Phe Glu Lys Lys  Lys Asn Asp Thr Leu  Asp Pro Glu 
    1265                 1270                 1275             


Pro Phe  Val Asp Cys Lys Glu  Cys Gly Arg Lys Met  His Gln Ile 
    1280                 1285                 1290             


Cys Val  Leu His Tyr Asp Ile  Ile Trp Pro Ser Gly  Phe Val Cys 
    1295                 1300                 1305             


Asp Asn  Cys Leu Lys Lys Thr  Gly Arg Pro Arg Lys  Glu Asn Lys 
    1310                 1315                 1320             


Phe Ser  Ala Lys Arg Leu Gln  Thr Thr Arg Leu Gly  Asn His Leu 
    1325                 1330                 1335             


Glu Asp  Arg Val Asn Lys Phe  Leu Arg Arg Gln Asn  His Pro Glu 
    1340                 1345                 1350             


Ala Gly  Glu Val Phe Val Arg  Val Val Ala Ser Ser  Asp Lys Thr 
    1355                 1360                 1365             


Val Glu  Val Lys Pro Gly Met  Lys Ser Arg Phe Val  Asp Ser Gly 
    1370                 1375                 1380             


Glu Met  Ser Glu Ser Phe Pro  Tyr Arg Thr Lys Ala  Leu Phe Ala 
    1385                 1390                 1395             


Phe Glu  Glu Ile Asp Gly Val  Asp Val Cys Phe Phe  Gly Met His 
    1400                 1405                 1410             


Val Gln  Glu Tyr Gly Ser Asp  Cys Pro Pro Pro Asn  Thr Arg Arg 
    1415                 1420                 1425             


Val Tyr  Ile Ser Tyr Leu Asp  Ser Ile His Phe Phe  Arg Pro Arg 
    1430                 1435                 1440             


Cys Leu  Arg Thr Ala Val Tyr  His Glu Ile Leu Ile  Gly Tyr Leu 
    1445                 1450                 1455             


Glu Tyr  Val Lys Lys Leu Gly  Tyr Val Thr Gly His  Ile Trp Ala 
    1460                 1465                 1470             


Cys Pro  Pro Ser Glu Gly Asp  Asp Tyr Ile Phe His  Cys His Pro 
    1475                 1480                 1485             


Pro Asp  Gln Lys Ile Pro Lys  Pro Lys Arg Leu Gln  Glu Trp Tyr 
    1490                 1495                 1500             


Lys Lys  Met Leu Asp Lys Ala  Phe Ala Glu Arg Ile  Ile His Asp 
    1505                 1510                 1515             


Tyr Lys  Asp Ile Phe Lys Gln  Ala Thr Glu Asp Arg  Leu Thr Ser 
    1520                 1525                 1530             


Ala Lys  Glu Leu Pro Tyr Phe  Glu Gly Asp Phe Trp  Pro Asn Val 
    1535                 1540                 1545             


Leu Glu  Glu Ser Ile Lys Glu  Leu Glu Gln Glu Glu  Glu Glu Arg 
    1550                 1555                 1560             


Lys Lys  Glu Glu Ser Thr Ala  Ala Ser Glu Thr Thr  Glu Gly Ser 
    1565                 1570                 1575             


Gln Gly  Asp Ser Lys Asn Ala  Lys Lys Lys Asn Asn  Lys Lys Thr 
    1580                 1585                 1590             


Asn Lys  Asn Lys Ser Ser Ile  Ser Arg Ala Asn Lys  Lys Lys Pro 
    1595                 1600                 1605             


Ser Met  Pro Asn Val Ser Asn  Asp Leu Ser Gln Lys  Leu Tyr Ala 
    1610                 1615                 1620             


Thr Met  Glu Lys His Lys Glu  Val Phe Phe Val Ile  His Leu His 
    1625                 1630                 1635             


Ala Gly  Pro Val Ile Asn Thr  Leu Pro Pro Ile Val  Asp Pro Asp 
    1640                 1645                 1650             


Pro Leu  Leu Ser Cys Asp Leu  Met Asp Gly Arg Asp  Ala Phe Leu 
    1655                 1660                 1665             


Thr Leu  Ala Arg Asp Lys His  Trp Glu Phe Ser Ser  Leu Arg Arg 
    1670                 1675                 1680             


Ser Lys  Trp Ser Thr Leu Cys  Met Leu Val Glu Leu  His Thr Gln 
    1685                 1690                 1695             


Gly Gln  Asp Arg Phe Val Tyr  Thr Cys Asn Glu Cys  Lys His His 
    1700                 1705                 1710             


Val Glu  Thr Arg Trp His Cys  Thr Val Cys Glu Asp  Tyr Asp Leu 
    1715                 1720                 1725             


Cys Ile  Asn Cys Tyr Asn Thr  Lys Ser His Ala His  Lys Met Val 
    1730                 1735                 1740             


Lys Trp  Gly Leu Gly Leu Asp  Asp Glu Gly Ser Ser  Gln Gly Glu 
    1745                 1750                 1755             


Pro Gln  Ser Lys Ser Pro Gln  Glu Ser Arg Arg Leu  Ser Ile Gln 
    1760                 1765                 1770             


Arg Cys  Ile Gln Ser Leu Val  His Ala Cys Gln Cys  Arg Asn Ala 
    1775                 1780                 1785             


Asn Cys  Ser Leu Pro Ser Cys  Gln Lys Met Lys Arg  Val Val Gln 
    1790                 1795                 1800             


His Thr  Lys Gly Cys Lys Arg  Lys Thr Asn Gly Gly  Cys Pro Val 
    1805                 1810                 1815             


Cys Lys  Gln Leu Ile Ala Leu  Cys Cys Tyr His Ala  Lys His Cys 
    1820                 1825                 1830             


Gln Glu  Asn Lys Cys Pro Val  Pro Phe Cys Leu Asn  Ile Lys His 
    1835                 1840                 1845             


Lys Leu  Arg Gln Gln Gln Ile  Gln His Arg Leu Gln  Gln Ala Gln 
    1850                 1855                 1860             


Leu Met  Arg Arg Arg Met Ala  Thr Met Asn Thr Arg  Asn Val Pro 
    1865                 1870                 1875             


Gln Gln  Ser Leu Pro Ser Pro  Thr Ser Ala Pro Pro  Gly Thr Pro 
    1880                 1885                 1890             


Thr Gln  Gln Pro Ser Thr Pro  Gln Thr Pro Gln Pro  Pro Ala Gln 
    1895                 1900                 1905             


Pro Gln  Pro Ser Pro Val Ser  Met Ser Pro Ala Gly  Phe Pro Ser 
    1910                 1915                 1920             


Val Ala  Arg Thr Gln Pro Pro  Thr Thr Val Ser Thr  Gly Lys Pro 
    1925                 1930                 1935             


Thr Ser  Gln Val Pro Ala Pro  Pro Pro Pro Ala Gln  Pro Pro Pro 
    1940                 1945                 1950             


Ala Ala  Val Glu Ala Ala Arg  Gln Ile Glu Arg Glu  Ala Gln Gln 
    1955                 1960                 1965             


Gln Gln  His Leu Tyr Arg Val  Asn Ile Asn Asn Ser  Met Pro Pro 
    1970                 1975                 1980             


Gly Arg  Thr Gly Met Gly Thr  Pro Gly Ser Gln Met  Ala Pro Val 
    1985                 1990                 1995             


Ser Leu  Asn Val Pro Arg Pro  Asn Gln Val Ser Gly  Pro Val Met 
    2000                 2005                 2010             


Pro Ser  Met Pro Pro Gly Gln  Trp Gln Gln Ala Pro  Leu Pro Gln 
    2015                 2020                 2025             


Gln Gln  Pro Met Pro Gly Leu  Pro Arg Pro Val Ile  Ser Met Gln 
    2030                 2035                 2040             


Ala Gln  Ala Ala Val Ala Gly  Pro Arg Met Pro Ser  Val Gln Pro 
    2045                 2050                 2055             


Pro Arg  Ser Ile Ser Pro Ser  Ala Leu Gln Asp Leu  Leu Arg Thr 
    2060                 2065                 2070             


Leu Lys  Ser Pro Ser Ser Pro  Gln Gln Gln Gln Gln  Val Leu Asn 
    2075                 2080                 2085             


Ile Leu  Lys Ser Asn Pro Gln  Leu Met Ala Ala Phe  Ile Lys Gln 
    2090                 2095                 2100             


Arg Thr  Ala Lys Tyr Val Ala  Asn Gln Pro Gly Met  Gln Pro Gln 
    2105                 2110                 2115             


Pro Gly  Leu Gln Ser Gln Pro  Gly Met Gln Pro Gln  Pro Gly Met 
    2120                 2125                 2130             


His Gln  Gln Pro Ser Leu Gln  Asn Leu Asn Ala Met  Gln Ala Gly 
    2135                 2140                 2145             


Val Pro  Arg Pro Gly Val Pro  Pro Gln Gln Gln Ala  Met Gly Gly 
    2150                 2155                 2160             


Leu Asn  Pro Gln Gly Gln Ala  Leu Asn Ile Met Asn  Pro Gly His 
    2165                 2170                 2175             


Asn Pro  Asn Met Ala Ser Met  Asn Pro Gln Tyr Arg  Glu Met Leu 
    2180                 2185                 2190             


Arg Arg  Gln Leu Leu Gln Gln  Gln Gln Gln Gln Gln  Gln Gln Gln 
    2195                 2200                 2205             


Gln Gln  Gln Gln Gln Gln Gln  Gln Gly Ser Ala Gly  Met Ala Gly 
    2210                 2215                 2220             


Gly Met  Ala Gly His Gly Gln  Phe Gln Gln Pro Gln  Gly Pro Gly 
    2225                 2230                 2235             


Gly Tyr  Pro Pro Ala Met Gln  Gln Gln Gln Arg Met  Gln Gln His 
    2240                 2245                 2250             


Leu Pro  Leu Gln Gly Ser Ser  Met Gly Gln Met Ala  Ala Gln Met 
    2255                 2260                 2265             


Gly Gln  Leu Gly Gln Met Gly  Gln Pro Gly Leu Gly  Ala Asp Ser 
    2270                 2275                 2280             


Thr Pro  Asn Ile Gln Gln Ala  Leu Gln Gln Arg Ile  Leu Gln Gln 
    2285                 2290                 2295             


Gln Gln  Met Lys Gln Gln Ile  Gly Ser Pro Gly Gln  Pro Asn Pro 
    2300                 2305                 2310             


Met Ser  Pro Gln Gln His Met  Leu Ser Gly Gln Pro  Gln Ala Ser 
    2315                 2320                 2325             


His Leu  Pro Gly Gln Gln Ile  Ala Thr Ser Leu Ser  Asn Gln Val 
    2330                 2335                 2340             


Arg Ser  Pro Ala Pro Val Gln  Ser Pro Arg Pro Gln  Ser Gln Pro 
    2345                 2350                 2355             


Pro His  Ser Ser Pro Ser Pro  Arg Ile Gln Pro Gln  Pro Ser Pro 
    2360                 2365                 2370             


His His  Val Ser Pro Gln Thr  Gly Ser Pro His Pro  Gly Leu Ala 
    2375                 2380                 2385             


Val Thr  Met Ala Ser Ser Ile  Asp Gln Gly His Leu  Gly Asn Pro 
    2390                 2395                 2400             


Glu Gln  Ser Ala Met Leu Pro  Gln Leu Asn Thr Pro  Ser Arg Ser 
    2405                 2410                 2415             


Ala Leu  Ser Ser Glu Leu Ser  Leu Val Gly Asp Thr  Thr Gly Asp 
    2420                 2425                 2430             


Thr Leu  Glu Lys Phe Val Glu  Gly Leu 
    2435                 2440         


<210>  25
<211>  10083
<212>  DNA
<213>  Homo sapiens

<400>  25
ctgcggggcg ctgttgctgt ggctgagatt tggccgccgc ctcccccacc cggcctgcgc       60

cctccctctc cctcggcgcc cgcccgcccg ctcgcggccc gcgctcgctc ctctccctcg      120

cagccggcag ggcccccgac ccccgtccgg gccctcgccg gcccggccgc ccgtgcccgg      180

ggctgttttc gcgagcaggt gaaaatggct gagaacttgc tggacggacc gcccaacccc      240

aaaagagcca aactcagctc gcccggtttc tcggcgaatg acagcacaga ttttggatca      300

ttgtttgact tggaaaatga tcttcctgat gagctgatac ccaatggagg agaattaggc      360

cttttaaaca gtgggaacct tgttccagat gctgcttcca aacataaaca actgtcggag      420

cttctacgag gaggcagcgg ctctagtatc aacccaggaa taggaaatgt gagcgccagc      480

agccccgtgc agcagggcct gggtggccag gctcaagggc agccgaacag tgctaacatg      540

gccagcctca gtgccatggg caagagccct ctgagccagg gagattcttc agcccccagc      600

ctgcctaaac aggcagccag cacctctggg cccacccccg ctgcctccca agcactgaat      660

ccgcaagcac aaaagcaagt ggggctggcg actagcagcc ctgccacgtc acagactgga      720

cctggtatct gcatgaatgc taactttaac cagacccacc caggcctcct caatagtaac      780

tctggccata gcttaattaa tcaggcttca caagggcagg cgcaagtcat gaatggatct      840

cttggggctg ctggcagagg aaggggagct ggaatgccgt accctactcc agccatgcag      900

ggcgcctcga gcagcgtgct ggctgagacc ctaacgcagg tttccccgca aatgactggt      960

cacgcgggac tgaacaccgc acaggcagga ggcatggcca agatgggaat aactgggaac     1020

acaagtccat ttggacagcc ctttagtcaa gctggagggc agccaatggg agccactgga     1080

gtgaaccccc agttagccag caaacagagc atggtcaaca gtttgcccac cttccctaca     1140

gatatcaaga atacttcagt caccaacgtg ccaaatatgt ctcagatgca aacatcagtg     1200

ggaattgtac ccacacaagc aattgcaaca ggccccactg cagatcctga aaaacgcaaa     1260

ctgatacagc agcagctggt tctactgctt catgctcata agtgtcagag acgagagcaa     1320

gcaaacggag aggttcgggc ctgctcgctc ccgcattgtc gaaccatgaa aaacgttttg     1380

aatcacatga cgcattgtca ggctgggaaa gcctgccaag ccatcctggg gtctccagct     1440

agtggaattc aaaacacaat tggttctgtt ggcacagggc aacagaatgc cacttcttta     1500

agtaacccaa atcccataga ccccagctcc atgcagcgag cctatgctgc tctcggactc     1560

ccctacatga accagcccca gacgcagctg cagcctcagg ttcctggcca gcaaccagca     1620

cagcctcaaa cccaccagca gatgaggact ctcaaccccc tgggaaataa tccaatgaac     1680

attccagcag gaggaataac aacagatcag cagcccccaa acttgatttc agaatcagct     1740

cttccgactt ccctgggggc cacaaaccca ctgatgaacg atggctccaa ctctggtaac     1800

attggaaccc tcagcactat accaacagca gctcctcctt ctagcaccgg tgtaaggaaa     1860

ggctggcacg aacatgtcac tcaggacctg cggagccatc tagtgcataa actcgtccaa     1920

gccatcttcc caacacctga tcccgcagct ctaaaggatc gccgcatgga aaacctggta     1980

gcctatgcta agaaagtgga aggggacatg tacgagtctg ccaacagcag ggatgaatat     2040

tatcacttat tagcagagaa aatctacaag atacaaaaag aactagaaga aaaacggagg     2100

tcgcgtttac ataaacaagg catcttgggg aaccagccag ccttaccagc cccgggggct     2160

cagccccctg tgattccaca ggcacaacct gtgagacctc caaatggacc cctgtccctg     2220

ccagtgaatc gcatgcaagt ttctcaaggg atgaattcat ttaaccccat gtccttgggg     2280

aacgtccagt tgccacaagc acccatggga cctcgtgcag cctccccaat gaaccactct     2340

gtccagatga acagcatggg ctcagtgcca gggatggcca tttctccttc ccgaatgcct     2400

cagcctccga acatgatggg tgcacacacc aacaacatga tggcccaggc gcccgctcag     2460

agccagtttc tgccacagaa ccagttcccg tcatccagcg gggcgatgag tgtgggcatg     2520

gggcagccgc cagcccaaac aggcgtgtca cagggacagg tgcctggtgc tgctcttcct     2580

aaccctctca acatgctggg gcctcaggcc agccagctac cttgccctcc agtgacacag     2640

tcaccactgc acccaacacc gcctcctgct tccacggctg ctggcatgcc atctctccag     2700

cacacgacac cacctgggat gactcctccc cagccagcag ctcccactca gccatcaact     2760

cctgtgtcgt cttccgggca gactcccacc ccgactcctg gctcagtgcc cagtgctacc     2820

caaacccaga gcacccctac agtccaggca gcagcccagg cccaggtgac cccgcagcct     2880

caaaccccag ttcagccccc gtctgtggct acccctcagt catcgcagca acagccgacg     2940

cctgtgcacg cccagcctcc tggcacaccg ctttcccagg cagcagccag cattgataac     3000

agagtcccta ccccctcctc ggtggccagc gcagaaacca attcccagca gccaggacct     3060

gacgtacctg tgctggaaat gaagacggag acccaagcag aggacactga gcccgatcct     3120

ggtgaatcca aaggggagcc caggtctgag atgatggagg aggatttgca aggagcttcc     3180

caagttaaag aagaaacaga catagcagag cagaaatcag aaccaatgga agtggatgaa     3240

aagaaacctg aagtgaaagt agaagttaaa gaggaagaag agagtagcag taacggcaca     3300

gcctctcagt caacatctcc ttcgcagccg cgcaaaaaaa tctttaaacc agaggagtta     3360

cgccaggccc tcatgccaac cctagaagca ctgtatcgac aggacccaga gtcattacct     3420

ttccggcagc ctgtagatcc ccagctcctc ggaattccag actattttga catcgtaaag     3480

aatcccatgg acctctccac catcaagcgg aagctggaca cagggcaata ccaagagccc     3540

tggcagtacg tggacgacgt ctggctcatg ttcaacaatg cctggctcta taatcgcaag     3600

acatcccgag tctataagtt ttgcagtaag cttgcagagg tctttgagca ggaaattgac     3660

cctgtcatgc agtcccttgg atattgctgt ggacgcaagt atgagttttc cccacagact     3720

ttgtgctgct atgggaagca gctgtgtacc attcctcgcg atgctgccta ctacagctat     3780

cagaataggt atcatttctg tgagaagtgt ttcacagaga tccagggcga gaatgtgacc     3840

ctgggtgacg acccttcaca gccccagacg acaatttcaa aggatcagtt tgaaaagaag     3900

aaaaatgata ccttagaccc cgaacctttc gttgattgca aggagtgtgg ccggaagatg     3960

catcagattt gcgttctgca ctatgacatc atttggcctt caggttttgt gtgcgacaac     4020

tgcttgaaga aaactggcag acctcgaaaa gaaaacaaat tcagtgctaa gaggctgcag     4080

accacaagac tgggaaacca cttggaagac cgagtgaaca aatttttgcg gcgccagaat     4140

caccctgaag ccggggaggt ttttgtccga gtggtggcca gctcagacaa gacggtggag     4200

gtcaagcccg ggatgaagtc acggtttgtg gattctgggg aaatgtctga atctttccca     4260

tatcgaacca aagctctgtt tgcttttgag gaaattgacg gcgtggatgt ctgctttttt     4320

ggaatgcacg tccaagaata cggctctgat tgcccccctc caaacacgag gcgtgtgtac     4380

atttcttatc tggatagtat tcatttcttc cggccacgtt gcctccgcac agccgtttac     4440

catgagatcc ttattggata tttagagtat gtgaagaaat tagggtatgt gacagggcac     4500

atctgggcct gtcctccaag tgaaggagat gattacatct tccattgcca cccacctgat     4560

caaaaaatac ccaagccaaa acgactgcag gagtggtaca aaaagatgct ggacaaggcg     4620

tttgcagagc ggatcatcca tgactacaag gatattttca aacaagcaac tgaagacagg     4680

ctcaccagtg ccaaggaact gccctatttt gaaggtgatt tctggcccaa tgtgttagaa     4740

gagagcatta aggaactaga acaagaagaa gaggagagga aaaaggaaga gagcactgca     4800

gccagtgaaa ccactgaggg cagtcagggc gacagcaaga atgccaagaa gaagaacaac     4860

aagaaaacca acaagaacaa aagcagcatc agccgcgcca acaagaagaa gcccagcatg     4920

cccaacgtgt ccaatgacct gtcccagaag ctgtatgcca ccatggagaa gcacaaggag     4980

gtcttcttcg tgatccacct gcacgctggg cctgtcatca acaccctgcc ccccatcgtc     5040

gaccccgacc ccctgctcag ctgtgacctc atggatgggc gcgacgcctt cctcaccctc     5100

gccagagaca agcactggga gttctcctcc ttgcgccgct ccaagtggtc cacgctctgc     5160

atgctggtgg agctgcacac ccagggccag gaccgctttg tctacacctg caacgagtgc     5220

aagcaccacg tggagacgcg ctggcactgc actgtgtgcg aggactacga cctctgcatc     5280

aactgctata acacgaagag ccatgcccat aagatggtga agtgggggct gggcctggat     5340

gacgagggca gcagccaggg cgagccacag tcaaagagcc cccaggagtc acgccggctg     5400

agcatccagc gctgcatcca gtcgctggtg cacgcgtgcc agtgccgcaa cgccaactgc     5460

tcgctgccat cctgccagaa gatgaagcgg gtggtgcagc acaccaaggg ctgcaaacgc     5520

aagaccaacg ggggctgccc ggtgtgcaag cagctcatcg ccctctgctg ctaccacgcc     5580

aagcactgcc aagaaaacaa atgccccgtg cccttctgcc tcaacatcaa acacaagctc     5640

cgccagcagc agatccagca ccgcctgcag caggcccagc tcatgcgccg gcggatggcc     5700

accatgaaca cccgcaacgt gcctcagcag agtctgcctt ctcctacctc agcaccgccc     5760

gggaccccca cacagcagcc cagcacaccc cagacgccgc agccccctgc ccagccccaa     5820

ccctcacccg tgagcatgtc accagctggc ttccccagcg tggcccggac tcagcccccc     5880

accacggtgt ccacagggaa gcctaccagc caggtgccgg cccccccacc cccggcccag     5940

ccccctcctg cagcggtgga agcggctcgg cagatcgagc gtgaggccca gcagcagcag     6000

cacctgtacc gggtgaacat caacaacagc atgcccccag gacgcacggg catggggacc     6060

ccggggagcc agatggcccc cgtgagcctg aatgtgcccc gacccaacca ggtgagcggg     6120

cccgtcatgc ccagcatgcc tcccgggcag tggcagcagg cgccccttcc ccagcagcag     6180

cccatgccag gcttgcccag gcctgtgata tccatgcagg cccaggcggc cgtggctggg     6240

ccccggatgc ccagcgtgca gccacccagg agcatctcac ccagcgctct gcaagacctg     6300

ctgcggaccc tgaagtcgcc cagctcccct cagcagcaac agcaggtgct gaacattctc     6360

aaatcaaacc cgcagctaat ggcagctttc atcaaacagc gcacagccaa gtacgtggcc     6420

aatcagcccg gcatgcagcc ccagcctggc ctccagtccc agcccggcat gcaaccccag     6480

cctggcatgc accagcagcc cagcctgcag aacctgaatg ccatgcaggc tggcgtgccg     6540

cggcccggtg tgcctccaca gcagcaggcg atgggaggcc tgaaccccca gggccaggcc     6600

ttgaacatca tgaacccagg acacaacccc aacatggcga gtatgaatcc acagtaccga     6660

gaaatgttac ggaggcagct gctgcagcag cagcagcaac agcagcagca acaacagcag     6720

caacagcagc agcagcaagg gagtgccggc atggctgggg gcatggcggg gcacggccag     6780

ttccagcagc ctcaaggacc cggaggctac ccaccggcca tgcagcagca gcagcgcatg     6840

cagcagcatc tccccctcca gggcagctcc atgggccaga tggcggctca gatgggacag     6900

cttggccaga tggggcagcc ggggctgggg gcagacagca cccccaacat ccagcaagcc     6960

ctgcagcagc ggattctgca gcaacagcag atgaagcagc agattgggtc cccaggccag     7020

ccgaacccca tgagccccca gcaacacatg ctctcaggac agccacaggc ctcgcatctc     7080

cctggccagc agatcgccac gtcccttagt aaccaggtgc ggtctccagc ccctgtccag     7140

tctccacggc cccagtccca gcctccacat tccagcccgt caccacggat acagccccag     7200

ccttcgccac accacgtctc accccagact ggttcccccc accccggact cgcagtcacc     7260

atggccagct ccatagatca gggacacttg gggaaccccg aacagagtgc aatgctcccc     7320

cagctgaaca cccccagcag gagtgcgctg tccagcgaac tgtccctggt cggggacacc     7380

acgggggaca cgctagagaa gtttgtggag ggcttgtagc attgtgagag catcaccttt     7440

tccctttcat gttcttggac cttttgtact gaaaatccag gcatctaggt tctttttatt     7500

cctagatgga actgcgactt ccgagccatg gaagggtgga ttgatgttta aagaaacaat     7560

acaaagaata tatttttttg ttaaaaacca gttgatttaa atatctggtc tctctctttg     7620

gttttttttt ggcggggggg tggggggggt tctttttttt ccgttttgtt tttgtttggg     7680

gggagggggg ttttgtttgg attctttttg tcgtcattgc tggtgactca tgcctttttt     7740

taacgggaaa aacaagttca ttatattcat attttttatt tgtattttca agactttaaa     7800

catttatgtt taaaagtaag aagaaaaata atattcagaa ctgattcctg aaataatgca     7860

agcttataat gtatcccgat aactttgtga tgtttcggga agattttttt ctatagtgaa     7920

ctctgtgggc gtctcccagt attaccctgg atgataggaa ttgactccgg cgtgcacaca     7980

cgtacacacc cacacacatc tatctataca taatggctga agccaaactt gtcttgcaga     8040

tgtagaaatt gttgctttgt ttctctgata aaactggttt tagacaaaaa atagggatga     8100

tcactcttag accatgctaa tgttactaga gaagaagcct tcttttcttt cttctatgtg     8160

aaacttgaaa tgaggaaaag caattctagt gtaaatcatg caagcgctct aattcctata     8220

aatacgaaac tcgagaagat tcaatcactg tatagaatgg taaaatacca actcatttct     8280

tatatcatat tgttaaataa actgtgtgca acagacaaaa agggtggtcc ttcttgaatt     8340

catgtacatg gtattaacac ttagtgttcg gggttttttg ttatgaaaat gctgttttca     8400

acattgtatt tggactatgc atgtgttttt tccccattgt atataaagta ccgcttaaaa     8460

ttgatataaa ttactgaggt ttttaacatg tattctgttc tttaagatcc ctgtaagaat     8520

gtttaaggtt tttatttatt tatatatatt ttttgagtct gttctttgta agacatggtt     8580

ctggttgttc gctcatagcg gagaggctgg ggctgcggtt gtggttgtgg cggcgtgggt     8640

ggtggctggg aactgtggcc caggcttagc ggccgcccgg aggcttttct tcccggagac     8700

tgaggtgggc gactgaggtg ggcggctcag cgttggcccc acacattcga ggctcacagg     8760

tgattgtcgc tcacacagtt agggtcgtca gttggtctga aactgcattt ggcccactcc     8820

tccatcctcc ctgtccgtcg tagctgccac ccccagaggc ggcgcttctt cccgtgttca     8880

ggcggctccc cccccccgta cacgactccc agaatctgag gcagagagtg ctccaggctc     8940

gcgaggtgct ttctgacttc cccccaaatc ctgccgctgc cgcgcagcat gtcccgtgtg     9000

gcgtttgagg aaatgctgag ggacagacac cttggagcac cagctccggt ccctgttaca     9060

gtgagaaagg tcccccactt cgggggatac ttgcacttag ccacatggtc ctgcctccct     9120

tggagtccag ttccaggctc ccttactgag tgggtgagac aagttcacaa aaaccgtaaa     9180

actgagagga ggaccatggg caggggagct gaagttcatc ccctaagtct accaccccca     9240

gcacccagag aacccacttt atccctagtc ccccaacaaa ggctggtcta ggtgggggtg     9300

atggtaattt tagaaatcac gccccaaata gcttccgttt gggcccttac attcacagat     9360

aggttttaaa tagctgaata cttggtttgg gaatctgaat tcgaggaacc tttctaagaa     9420

gttggaaagg tccgatctag ttttagcaca gagctttgaa ccttgagtta taaaatgcag     9480

aataattcaa gtaaaaataa gaccaccatc tggcacccct gaccagcccc cattcacccc     9540

atcccaggag gggaagcaca ggccgggcct ccggtggaga ttgctgccac tgctcggcct     9600

gctgggttct taacctccag tgtcctcttc atcttttcca cccgtaggga aaccttgagc     9660

catgtgttca aacaagaagt ggggctagag cccgagagca gcagctctaa gcccacactc     9720

agaaagtggc gccctcctgg ttgtgcagcc ttttaatgtg ggcagtggag gggcctctgt     9780

ttcaggttat cctggaattc aaaacgttat gtaccaacct catcctcttt ggagtctgca     9840

tcctgtgcaa ccgtcttggg caatccagat gtcgaaggat gtgaccgaga gcatggtctg     9900

tggatgctaa ccctaagttt gtcgtaagga aatttctgta agaaacctgg aaagccccaa     9960

cgctgtgtct catgctgtat acttaagagg agaagaaaaa gtcctatatt tgtgatcaaa    10020

aagaggaaac ttgaaatgtg atggtgttta taataaaaga tggtaaaact acttggattc    10080

aaa                                                                  10083


<210>  26
<211>  2404
<212>  PRT
<213>  Homo sapiens

<400>  26

Met Ala Glu Asn Leu Leu Asp Gly Pro Pro Asn Pro Lys Arg Ala Lys 
1               5                   10                  15      


Leu Ser Ser Pro Gly Phe Ser Ala Asn Asp Ser Thr Asp Phe Gly Ser 
            20                  25                  30          


Leu Phe Asp Leu Glu Asn Asp Leu Pro Asp Glu Leu Ile Pro Asn Gly 
        35                  40                  45              


Gly Glu Leu Gly Leu Leu Asn Ser Gly Asn Leu Val Pro Asp Ala Ala 
    50                  55                  60                  


Ser Lys His Lys Gln Leu Ser Glu Leu Leu Arg Gly Gly Ser Gly Ser 
65                  70                  75                  80  


Ser Ile Asn Pro Gly Ile Gly Asn Val Ser Ala Ser Ser Pro Val Gln 
                85                  90                  95      


Gln Gly Leu Gly Gly Gln Ala Gln Gly Gln Pro Asn Ser Ala Asn Met 
            100                 105                 110         


Ala Ser Leu Ser Ala Met Gly Lys Ser Pro Leu Ser Gln Gly Asp Ser 
        115                 120                 125             


Ser Ala Pro Ser Leu Pro Lys Gln Ala Ala Ser Thr Ser Gly Pro Thr 
    130                 135                 140                 


Pro Ala Ala Ser Gln Ala Leu Asn Pro Gln Ala Gln Lys Gln Val Gly 
145                 150                 155                 160 


Leu Ala Thr Ser Ser Pro Ala Thr Ser Gln Thr Gly Pro Gly Ile Cys 
                165                 170                 175     


Met Asn Ala Asn Phe Asn Gln Thr His Pro Gly Leu Leu Asn Ser Asn 
            180                 185                 190         


Ser Gly His Ser Leu Ile Asn Gln Ala Ser Gln Gly Gln Ala Gln Val 
        195                 200                 205             


Met Asn Gly Ser Leu Gly Ala Ala Gly Arg Gly Arg Gly Ala Gly Met 
    210                 215                 220                 


Pro Tyr Pro Thr Pro Ala Met Gln Gly Ala Ser Ser Ser Val Leu Ala 
225                 230                 235                 240 


Glu Thr Leu Thr Gln Val Ser Pro Gln Met Thr Gly His Ala Gly Leu 
                245                 250                 255     


Asn Thr Ala Gln Ala Gly Gly Met Ala Lys Met Gly Ile Thr Gly Asn 
            260                 265                 270         


Thr Ser Pro Phe Gly Gln Pro Phe Ser Gln Ala Gly Gly Gln Pro Met 
        275                 280                 285             


Gly Ala Thr Gly Val Asn Pro Gln Leu Ala Ser Lys Gln Ser Met Val 
    290                 295                 300                 


Asn Ser Leu Pro Thr Phe Pro Thr Asp Ile Lys Asn Thr Ser Val Thr 
305                 310                 315                 320 


Asn Val Pro Asn Met Ser Gln Met Gln Thr Ser Val Gly Ile Val Pro 
                325                 330                 335     


Thr Gln Ala Ile Ala Thr Gly Pro Thr Ala Asp Pro Glu Lys Arg Lys 
            340                 345                 350         


Leu Ile Gln Gln Gln Leu Val Leu Leu Leu His Ala His Lys Cys Gln 
        355                 360                 365             


Arg Arg Glu Gln Ala Asn Gly Glu Val Arg Ala Cys Ser Leu Pro His 
    370                 375                 380                 


Cys Arg Thr Met Lys Asn Val Leu Asn His Met Thr His Cys Gln Ala 
385                 390                 395                 400 


Gly Lys Ala Cys Gln Ala Ile Leu Gly Ser Pro Ala Ser Gly Ile Gln 
                405                 410                 415     


Asn Thr Ile Gly Ser Val Gly Thr Gly Gln Gln Asn Ala Thr Ser Leu 
            420                 425                 430         


Ser Asn Pro Asn Pro Ile Asp Pro Ser Ser Met Gln Arg Ala Tyr Ala 
        435                 440                 445             


Ala Leu Gly Leu Pro Tyr Met Asn Gln Pro Gln Thr Gln Leu Gln Pro 
    450                 455                 460                 


Gln Val Pro Gly Gln Gln Pro Ala Gln Pro Gln Thr His Gln Gln Met 
465                 470                 475                 480 


Arg Thr Leu Asn Pro Leu Gly Asn Asn Pro Met Asn Ile Pro Ala Gly 
                485                 490                 495     


Gly Ile Thr Thr Asp Gln Gln Pro Pro Asn Leu Ile Ser Glu Ser Ala 
            500                 505                 510         


Leu Pro Thr Ser Leu Gly Ala Thr Asn Pro Leu Met Asn Asp Gly Ser 
        515                 520                 525             


Asn Ser Gly Asn Ile Gly Thr Leu Ser Thr Ile Pro Thr Ala Ala Pro 
    530                 535                 540                 


Pro Ser Ser Thr Gly Val Arg Lys Gly Trp His Glu His Val Thr Gln 
545                 550                 555                 560 


Asp Leu Arg Ser His Leu Val His Lys Leu Val Gln Ala Ile Phe Pro 
                565                 570                 575     


Thr Pro Asp Pro Ala Ala Leu Lys Asp Arg Arg Met Glu Asn Leu Val 
            580                 585                 590         


Ala Tyr Ala Lys Lys Val Glu Gly Asp Met Tyr Glu Ser Ala Asn Ser 
        595                 600                 605             


Arg Asp Glu Tyr Tyr His Leu Leu Ala Glu Lys Ile Tyr Lys Ile Gln 
    610                 615                 620                 


Lys Glu Leu Glu Glu Lys Arg Arg Ser Arg Leu His Lys Gln Gly Ile 
625                 630                 635                 640 


Leu Gly Asn Gln Pro Ala Leu Pro Ala Pro Gly Ala Gln Pro Pro Val 
                645                 650                 655     


Ile Pro Gln Ala Gln Pro Val Arg Pro Pro Asn Gly Pro Leu Ser Leu 
            660                 665                 670         


Pro Val Asn Arg Met Gln Val Ser Gln Gly Met Asn Ser Phe Asn Pro 
        675                 680                 685             


Met Ser Leu Gly Asn Val Gln Leu Pro Gln Ala Pro Met Gly Pro Arg 
    690                 695                 700                 


Ala Ala Ser Pro Met Asn His Ser Val Gln Met Asn Ser Met Gly Ser 
705                 710                 715                 720 


Val Pro Gly Met Ala Ile Ser Pro Ser Arg Met Pro Gln Pro Pro Asn 
                725                 730                 735     


Met Met Gly Ala His Thr Asn Asn Met Met Ala Gln Ala Pro Ala Gln 
            740                 745                 750         


Ser Gln Phe Leu Pro Gln Asn Gln Phe Pro Ser Ser Ser Gly Ala Met 
        755                 760                 765             


Ser Val Gly Met Gly Gln Pro Pro Ala Gln Thr Gly Val Ser Gln Gly 
    770                 775                 780                 


Gln Val Pro Gly Ala Ala Leu Pro Asn Pro Leu Asn Met Leu Gly Pro 
785                 790                 795                 800 


Gln Ala Ser Gln Leu Pro Cys Pro Pro Val Thr Gln Ser Pro Leu His 
                805                 810                 815     


Pro Thr Pro Pro Pro Ala Ser Thr Ala Ala Gly Met Pro Ser Leu Gln 
            820                 825                 830         


His Thr Thr Pro Pro Gly Met Thr Pro Pro Gln Pro Ala Ala Pro Thr 
        835                 840                 845             


Gln Pro Ser Thr Pro Val Ser Ser Ser Gly Gln Thr Pro Thr Pro Thr 
    850                 855                 860                 


Pro Gly Ser Val Pro Ser Ala Thr Gln Thr Gln Ser Thr Pro Thr Val 
865                 870                 875                 880 


Gln Ala Ala Ala Gln Ala Gln Val Thr Pro Gln Pro Gln Thr Pro Val 
                885                 890                 895     


Gln Pro Pro Ser Val Ala Thr Pro Gln Ser Ser Gln Gln Gln Pro Thr 
            900                 905                 910         


Pro Val His Ala Gln Pro Pro Gly Thr Pro Leu Ser Gln Ala Ala Ala 
        915                 920                 925             


Ser Ile Asp Asn Arg Val Pro Thr Pro Ser Ser Val Ala Ser Ala Glu 
    930                 935                 940                 


Thr Asn Ser Gln Gln Pro Gly Pro Asp Val Pro Val Leu Glu Met Lys 
945                 950                 955                 960 


Thr Glu Thr Gln Ala Glu Asp Thr Glu Pro Asp Pro Gly Glu Ser Lys 
                965                 970                 975     


Gly Glu Pro Arg Ser Glu Met Met Glu Glu Asp Leu Gln Gly Ala Ser 
            980                 985                 990         


Gln Val Lys Glu Glu Thr Asp Ile  Ala Glu Gln Lys Ser  Glu Pro Met 
        995                 1000                 1005             


Glu Val  Asp Glu Lys Lys Pro  Glu Val Lys Val Glu  Val Lys Glu 
    1010                 1015                 1020             


Glu Glu  Glu Ser Ser Ser Asn  Gly Thr Ala Ser Gln  Ser Thr Ser 
    1025                 1030                 1035             


Pro Ser  Gln Pro Arg Lys Lys  Ile Phe Lys Pro Glu  Glu Leu Arg 
    1040                 1045                 1050             


Gln Ala  Leu Met Pro Thr Leu  Glu Ala Leu Tyr Arg  Gln Asp Pro 
    1055                 1060                 1065             


Glu Ser  Leu Pro Phe Arg Gln  Pro Val Asp Pro Gln  Leu Leu Gly 
    1070                 1075                 1080             


Ile Pro  Asp Tyr Phe Asp Ile  Val Lys Asn Pro Met  Asp Leu Ser 
    1085                 1090                 1095             


Thr Ile  Lys Arg Lys Leu Asp  Thr Gly Gln Tyr Gln  Glu Pro Trp 
    1100                 1105                 1110             


Gln Tyr  Val Asp Asp Val Trp  Leu Met Phe Asn Asn  Ala Trp Leu 
    1115                 1120                 1125             


Tyr Asn  Arg Lys Thr Ser Arg  Val Tyr Lys Phe Cys  Ser Lys Leu 
    1130                 1135                 1140             


Ala Glu  Val Phe Glu Gln Glu  Ile Asp Pro Val Met  Gln Ser Leu 
    1145                 1150                 1155             


Gly Tyr  Cys Cys Gly Arg Lys  Tyr Glu Phe Ser Pro  Gln Thr Leu 
    1160                 1165                 1170             


Cys Cys  Tyr Gly Lys Gln Leu  Cys Thr Ile Pro Arg  Asp Ala Ala 
    1175                 1180                 1185             


Tyr Tyr  Ser Tyr Gln Asn Arg  Tyr His Phe Cys Glu  Lys Cys Phe 
    1190                 1195                 1200             


Thr Glu  Ile Gln Gly Glu Asn  Val Thr Leu Gly Asp  Asp Pro Ser 
    1205                 1210                 1215             


Gln Pro  Gln Thr Thr Ile Ser  Lys Asp Gln Phe Glu  Lys Lys Lys 
    1220                 1225                 1230             


Asn Asp  Thr Leu Asp Pro Glu  Pro Phe Val Asp Cys  Lys Glu Cys 
    1235                 1240                 1245             


Gly Arg  Lys Met His Gln Ile  Cys Val Leu His Tyr  Asp Ile Ile 
    1250                 1255                 1260             


Trp Pro  Ser Gly Phe Val Cys  Asp Asn Cys Leu Lys  Lys Thr Gly 
    1265                 1270                 1275             


Arg Pro  Arg Lys Glu Asn Lys  Phe Ser Ala Lys Arg  Leu Gln Thr 
    1280                 1285                 1290             


Thr Arg  Leu Gly Asn His Leu  Glu Asp Arg Val Asn  Lys Phe Leu 
    1295                 1300                 1305             


Arg Arg  Gln Asn His Pro Glu  Ala Gly Glu Val Phe  Val Arg Val 
    1310                 1315                 1320             


Val Ala  Ser Ser Asp Lys Thr  Val Glu Val Lys Pro  Gly Met Lys 
    1325                 1330                 1335             


Ser Arg  Phe Val Asp Ser Gly  Glu Met Ser Glu Ser  Phe Pro Tyr 
    1340                 1345                 1350             


Arg Thr  Lys Ala Leu Phe Ala  Phe Glu Glu Ile Asp  Gly Val Asp 
    1355                 1360                 1365             


Val Cys  Phe Phe Gly Met His  Val Gln Glu Tyr Gly  Ser Asp Cys 
    1370                 1375                 1380             


Pro Pro  Pro Asn Thr Arg Arg  Val Tyr Ile Ser Tyr  Leu Asp Ser 
    1385                 1390                 1395             


Ile His  Phe Phe Arg Pro Arg  Cys Leu Arg Thr Ala  Val Tyr His 
    1400                 1405                 1410             


Glu Ile  Leu Ile Gly Tyr Leu  Glu Tyr Val Lys Lys  Leu Gly Tyr 
    1415                 1420                 1425             


Val Thr  Gly His Ile Trp Ala  Cys Pro Pro Ser Glu  Gly Asp Asp 
    1430                 1435                 1440             


Tyr Ile  Phe His Cys His Pro  Pro Asp Gln Lys Ile  Pro Lys Pro 
    1445                 1450                 1455             


Lys Arg  Leu Gln Glu Trp Tyr  Lys Lys Met Leu Asp  Lys Ala Phe 
    1460                 1465                 1470             


Ala Glu  Arg Ile Ile His Asp  Tyr Lys Asp Ile Phe  Lys Gln Ala 
    1475                 1480                 1485             


Thr Glu  Asp Arg Leu Thr Ser  Ala Lys Glu Leu Pro  Tyr Phe Glu 
    1490                 1495                 1500             


Gly Asp  Phe Trp Pro Asn Val  Leu Glu Glu Ser Ile  Lys Glu Leu 
    1505                 1510                 1515             


Glu Gln  Glu Glu Glu Glu Arg  Lys Lys Glu Glu Ser  Thr Ala Ala 
    1520                 1525                 1530             


Ser Glu  Thr Thr Glu Gly Ser  Gln Gly Asp Ser Lys  Asn Ala Lys 
    1535                 1540                 1545             


Lys Lys  Asn Asn Lys Lys Thr  Asn Lys Asn Lys Ser  Ser Ile Ser 
    1550                 1555                 1560             


Arg Ala  Asn Lys Lys Lys Pro  Ser Met Pro Asn Val  Ser Asn Asp 
    1565                 1570                 1575             


Leu Ser  Gln Lys Leu Tyr Ala  Thr Met Glu Lys His  Lys Glu Val 
    1580                 1585                 1590             


Phe Phe  Val Ile His Leu His  Ala Gly Pro Val Ile  Asn Thr Leu 
    1595                 1600                 1605             


Pro Pro  Ile Val Asp Pro Asp  Pro Leu Leu Ser Cys  Asp Leu Met 
    1610                 1615                 1620             


Asp Gly  Arg Asp Ala Phe Leu  Thr Leu Ala Arg Asp  Lys His Trp 
    1625                 1630                 1635             


Glu Phe  Ser Ser Leu Arg Arg  Ser Lys Trp Ser Thr  Leu Cys Met 
    1640                 1645                 1650             


Leu Val  Glu Leu His Thr Gln  Gly Gln Asp Arg Phe  Val Tyr Thr 
    1655                 1660                 1665             


Cys Asn  Glu Cys Lys His His  Val Glu Thr Arg Trp  His Cys Thr 
    1670                 1675                 1680             


Val Cys  Glu Asp Tyr Asp Leu  Cys Ile Asn Cys Tyr  Asn Thr Lys 
    1685                 1690                 1695             


Ser His  Ala His Lys Met Val  Lys Trp Gly Leu Gly  Leu Asp Asp 
    1700                 1705                 1710             


Glu Gly  Ser Ser Gln Gly Glu  Pro Gln Ser Lys Ser  Pro Gln Glu 
    1715                 1720                 1725             


Ser Arg  Arg Leu Ser Ile Gln  Arg Cys Ile Gln Ser  Leu Val His 
    1730                 1735                 1740             


Ala Cys  Gln Cys Arg Asn Ala  Asn Cys Ser Leu Pro  Ser Cys Gln 
    1745                 1750                 1755             


Lys Met  Lys Arg Val Val Gln  His Thr Lys Gly Cys  Lys Arg Lys 
    1760                 1765                 1770             


Thr Asn  Gly Gly Cys Pro Val  Cys Lys Gln Leu Ile  Ala Leu Cys 
    1775                 1780                 1785             


Cys Tyr  His Ala Lys His Cys  Gln Glu Asn Lys Cys  Pro Val Pro 
    1790                 1795                 1800             


Phe Cys  Leu Asn Ile Lys His  Lys Leu Arg Gln Gln  Gln Ile Gln 
    1805                 1810                 1815             


His Arg  Leu Gln Gln Ala Gln  Leu Met Arg Arg Arg  Met Ala Thr 
    1820                 1825                 1830             


Met Asn  Thr Arg Asn Val Pro  Gln Gln Ser Leu Pro  Ser Pro Thr 
    1835                 1840                 1845             


Ser Ala  Pro Pro Gly Thr Pro  Thr Gln Gln Pro Ser  Thr Pro Gln 
    1850                 1855                 1860             


Thr Pro  Gln Pro Pro Ala Gln  Pro Gln Pro Ser Pro  Val Ser Met 
    1865                 1870                 1875             


Ser Pro  Ala Gly Phe Pro Ser  Val Ala Arg Thr Gln  Pro Pro Thr 
    1880                 1885                 1890             


Thr Val  Ser Thr Gly Lys Pro  Thr Ser Gln Val Pro  Ala Pro Pro 
    1895                 1900                 1905             


Pro Pro  Ala Gln Pro Pro Pro  Ala Ala Val Glu Ala  Ala Arg Gln 
    1910                 1915                 1920             


Ile Glu  Arg Glu Ala Gln Gln  Gln Gln His Leu Tyr  Arg Val Asn 
    1925                 1930                 1935             


Ile Asn  Asn Ser Met Pro Pro  Gly Arg Thr Gly Met  Gly Thr Pro 
    1940                 1945                 1950             


Gly Ser  Gln Met Ala Pro Val  Ser Leu Asn Val Pro  Arg Pro Asn 
    1955                 1960                 1965             


Gln Val  Ser Gly Pro Val Met  Pro Ser Met Pro Pro  Gly Gln Trp 
    1970                 1975                 1980             


Gln Gln  Ala Pro Leu Pro Gln  Gln Gln Pro Met Pro  Gly Leu Pro 
    1985                 1990                 1995             


Arg Pro  Val Ile Ser Met Gln  Ala Gln Ala Ala Val  Ala Gly Pro 
    2000                 2005                 2010             


Arg Met  Pro Ser Val Gln Pro  Pro Arg Ser Ile Ser  Pro Ser Ala 
    2015                 2020                 2025             


Leu Gln  Asp Leu Leu Arg Thr  Leu Lys Ser Pro Ser  Ser Pro Gln 
    2030                 2035                 2040             


Gln Gln  Gln Gln Val Leu Asn  Ile Leu Lys Ser Asn  Pro Gln Leu 
    2045                 2050                 2055             


Met Ala  Ala Phe Ile Lys Gln  Arg Thr Ala Lys Tyr  Val Ala Asn 
    2060                 2065                 2070             


Gln Pro  Gly Met Gln Pro Gln  Pro Gly Leu Gln Ser  Gln Pro Gly 
    2075                 2080                 2085             


Met Gln  Pro Gln Pro Gly Met  His Gln Gln Pro Ser  Leu Gln Asn 
    2090                 2095                 2100             


Leu Asn  Ala Met Gln Ala Gly  Val Pro Arg Pro Gly  Val Pro Pro 
    2105                 2110                 2115             


Gln Gln  Gln Ala Met Gly Gly  Leu Asn Pro Gln Gly  Gln Ala Leu 
    2120                 2125                 2130             


Asn Ile  Met Asn Pro Gly His  Asn Pro Asn Met Ala  Ser Met Asn 
    2135                 2140                 2145             


Pro Gln  Tyr Arg Glu Met Leu  Arg Arg Gln Leu Leu  Gln Gln Gln 
    2150                 2155                 2160             


Gln Gln  Gln Gln Gln Gln Gln  Gln Gln Gln Gln Gln  Gln Gln Gln 
    2165                 2170                 2175             


Gly Ser  Ala Gly Met Ala Gly  Gly Met Ala Gly His  Gly Gln Phe 
    2180                 2185                 2190             


Gln Gln  Pro Gln Gly Pro Gly  Gly Tyr Pro Pro Ala  Met Gln Gln 
    2195                 2200                 2205             


Gln Gln  Arg Met Gln Gln His  Leu Pro Leu Gln Gly  Ser Ser Met 
    2210                 2215                 2220             


Gly Gln  Met Ala Ala Gln Met  Gly Gln Leu Gly Gln  Met Gly Gln 
    2225                 2230                 2235             


Pro Gly  Leu Gly Ala Asp Ser  Thr Pro Asn Ile Gln  Gln Ala Leu 
    2240                 2245                 2250             


Gln Gln  Arg Ile Leu Gln Gln  Gln Gln Met Lys Gln  Gln Ile Gly 
    2255                 2260                 2265             


Ser Pro  Gly Gln Pro Asn Pro  Met Ser Pro Gln Gln  His Met Leu 
    2270                 2275                 2280             


Ser Gly  Gln Pro Gln Ala Ser  His Leu Pro Gly Gln  Gln Ile Ala 
    2285                 2290                 2295             


Thr Ser  Leu Ser Asn Gln Val  Arg Ser Pro Ala Pro  Val Gln Ser 
    2300                 2305                 2310             


Pro Arg  Pro Gln Ser Gln Pro  Pro His Ser Ser Pro  Ser Pro Arg 
    2315                 2320                 2325             


Ile Gln  Pro Gln Pro Ser Pro  His His Val Ser Pro  Gln Thr Gly 
    2330                 2335                 2340             


Ser Pro  His Pro Gly Leu Ala  Val Thr Met Ala Ser  Ser Ile Asp 
    2345                 2350                 2355             


Gln Gly  His Leu Gly Asn Pro  Glu Gln Ser Ala Met  Leu Pro Gln 
    2360                 2365                 2370             


Leu Asn  Thr Pro Ser Arg Ser  Ala Leu Ser Ser Glu  Leu Ser Leu 
    2375                 2380                 2385             


Val Gly  Asp Thr Thr Gly Asp  Thr Leu Glu Lys Phe  Val Glu Gly 
    2390                 2395                 2400             


Leu 
    


