                         SEQUENCE LISTING

<110>  Emory University
       Children's Healthcare of Atlanta, Inc.
       Spencer, Harold T.
       Doering, Christopher
       Raikar, Sunil
       Fleischer, Lauren
 
<120>  T-Cell Antigen Targeted Chimeric Antigen Receptor (CAR) and Uses 
       in Cell Therapies

<130>  17172 PCT

<150>  US 62/518,588
<151>  2017-06-12

<160>  10    

<170>  PatentIn version 3.5

<210>  1
<211>  348
<212>  PRT
<213>  Homo sapiens

<400>  1

Arg Leu Ser Trp Tyr Asp Pro Asp Phe Gln Ala Arg Leu Thr Arg Ser 
1               5                   10                  15      


Asn Ser Lys Cys Gln Gly Gln Leu Glu Val Tyr Leu Lys Asp Gly Trp 
            20                  25                  30          


His Met Val Cys Ser Gln Ser Trp Gly Arg Ser Ser Lys Gln Trp Glu 
        35                  40                  45              


Asp Pro Ser Gln Ala Ser Lys Val Cys Gln Arg Leu Asn Cys Gly Val 
    50                  55                  60                  


Pro Leu Ser Leu Gly Pro Phe Leu Val Thr Tyr Thr Pro Gln Ser Ser 
65                  70                  75                  80  


Ile Ile Cys Tyr Gly Gln Leu Gly Ser Phe Ser Asn Cys Ser His Ser 
                85                  90                  95      


Arg Asn Asp Met Cys His Ser Leu Gly Leu Thr Cys Leu Glu Pro Gln 
            100                 105                 110         


Lys Thr Thr Pro Pro Thr Thr Arg Pro Pro Pro Thr Thr Thr Pro Glu 
        115                 120                 125             


Pro Thr Ala Pro Pro Arg Leu Gln Leu Val Ala Gln Ser Gly Gly Gln 
    130                 135                 140                 


His Cys Ala Gly Val Val Glu Phe Tyr Ser Gly Ser Leu Gly Gly Thr 
145                 150                 155                 160 


Ile Ser Tyr Glu Ala Gln Asp Lys Thr Gln Asp Leu Glu Asn Phe Leu 
                165                 170                 175     


Cys Asn Asn Leu Gln Cys Gly Ser Phe Leu Lys His Leu Pro Glu Thr 
            180                 185                 190         


Glu Ala Gly Arg Ala Gln Asp Pro Gly Glu Pro Arg Glu His Gln Pro 
        195                 200                 205             


Leu Pro Ile Gln Trp Lys Ile Gln Asn Ser Ser Cys Thr Ser Leu Glu 
    210                 215                 220                 


His Cys Phe Arg Lys Ile Lys Pro Gln Lys Ser Gly Arg Val Leu Ala 
225                 230                 235                 240 


Leu Leu Cys Ser Gly Phe Gln Pro Lys Val Gln Ser Arg Leu Val Gly 
                245                 250                 255     


Gly Ser Ser Ile Cys Glu Gly Thr Val Glu Val Arg Gln Gly Ala Gln 
            260                 265                 270         


Trp Ala Ala Leu Cys Asp Ser Ser Ser Ala Arg Ser Ser Leu Arg Trp 
        275                 280                 285             


Glu Glu Val Cys Arg Glu Gln Gln Cys Gly Ser Val Asn Ser Tyr Arg 
    290                 295                 300                 


Val Leu Asp Ala Gly Asp Pro Thr Ser Arg Gly Leu Phe Cys Pro His 
305                 310                 315                 320 


Gln Lys Leu Ser Gln Cys His Glu Leu Trp Glu Arg Asn Ser Tyr Cys 
                325                 330                 335     


Lys Lys Val Phe Val Thr Cys Gln Asp Pro Asn Pro 
            340                 345             


<210>  2
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic construct

<400>  2
cctgctgggg atgctgggtg agt                                               23


<210>  3
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic construct

<400>  3
ccggtggggg gtgggggggg a                                                 21


<210>  4
<211>  3
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic construct


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  n is a, c, g, or t

<400>  4
ngg                                                                      3


<210>  5
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic construct

<400>  5
agcggttgca gagaccccat                                                   20


<210>  6
<211>  1298
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic construct

<400>  6
atgtacagga tgcaactccg tcttgcattg cactaagtct tgcacttgtc acgaattcgg       60

gcgcgccttg tccttcacag tgctcctgca gcggaaccga ggtccattgt cagagaaaat      120

ccctggcttc agtccctgcc ggaatcccaa ccacaacaag ggtgctgtac ctgcacgtca      180

acgagattac taagttcgaa ccaggagtgt ttgaccgcct ggtcaacctg cagcagctgt      240

atctgggagg aaatcagctg agcgccctgc cagacggcgt gttcgatcga ctgactcagc      300

tgaccagact ggatctgtac aacaatcagc tgaccgtgct gcctgccggg gtctttgacc      360

gactggtgaa tctgcagaca ctggatctgc acaacaatca gctgaagtct atccccagag      420

gcgcattcga caacctgaaa agtctgaccc atatttggct gtttgggaat ccttgggact      480

gcgcctgtag cgatatcctg tatctgtccg gatggctggg acagcatgca gggaaagagc      540

agggacaggc tgtctgctct ggcaccaaca cacccgtgcg ggctgtcacc gaggcatcaa      600

catccccatc aaagtgtcct ggctacgtgg caacaaccag atctgctagc gagcagaagc      660

tgatcagcga ggaggacctg gacaatgaga agagcaatgg aaccattatc catgtgaaag      720

ggaaacacct ttgtccaagt cccctatttc ccggaccttc taagcccttt tgggtgctgg      780

tggtggttgg tggagtcctg gcttgctata gcttgctagt aacagtggcc tttattattt      840

tctgggtgag gagtaagagg agcaggctcc tgcacagtga ctacatgaac atgactccca      900

ggaggcctgg gccaacccgc aagcattacc agccctatgc cccaccacgc gacttcgcag      960

cctatcgctc cagcaggagc gcagacgctc ccgcgtacca gcagggccag aaccagctct     1020

ataacgagct caatctagga cgaagagagg agtacgatgt tttggacaag agacgtggcc     1080

gggaccctga gatgggaggc aagccgagaa ggaagaaccc tcaggaaggc ctgtacaatg     1140

aactgcagaa agataagatg gcggaggcct acagtgagat tgggatgaaa ggcgagcgcc     1200

ggaggggcaa ggggcacgat ggcctttacc agggtctcag tacagccacc aaggacacct     1260

acgacgccct tcacatgcag gccctgcctc ctcgctga                             1298


<210>  7
<211>  1439
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic construct

<400>  7
atgtacagga tgcaactcct gtcttgcatt gcactaagtc ttgcacttgt cacgaattcg       60

ggcgcgcctg aaattcagtt ggtgcaaagc ggaggtggcc ttgtgaagcc aggaggcagt      120

gtgcgaatta gttgtgcagc ctccggttac acgttcacca actatggcat gaactgggtg      180

agacaggccc ccggcaaggg gttggaatgg atgggctgga ttaacacaca tacgggcgaa      240

ccgacatacg ccgacagctt taaaggtcga tttactttta gcttggacga ttccaaaaat      300

acggcatacc tgcaaataaa ctcactgcgg gcagaggata cggccgtata tttttgtacg      360

cggagagggt acgattggta ctttgatgtc tggggacagg ggacgacagt aaccgtgtct      420

agtggcgggg gaggatcagg tggtggcggt agcggtggag gtggaagtga tatccagatg      480

acacaatcac cgagttccct gtccgcgtca gtaggggatc gggtgacaat tacatgtaga      540

gcatctcaag acatcaatag ctacctgagc tggtttcagc aaaagcccgg aaaagctccg      600

aaaactctga tttatcgggc caatcgcctt gagtctgggg tgccaagtag attttcaggc      660

tccgggagcg ggacggacta tacgttgacc atatcaagtc ttcagtacga ggacttcggg      720

atatactatt gccaacagta cgatgagagc ccgtggacct tcgggggtgg gacaaagttg      780

gagatcaaag ctagcgagca gaagctgatc agcgaggagg acctggacaa tgagaagagc      840

aatggaacca ttatccatgt gaaagggaaa cacctttgtc caagtcccct atttcccgga      900

ccttctaagc ccttttgggt gctggtggtg gttggtggag tcctggcttg ctatagcttg      960

ctagtaacag tggcctttat tattttctgg gtgaggagta agaggagcag gctcctgcac     1020

agtgactaca tgaacatgac tcccaggagg cctgggccaa cccgcaagca ttaccagccc     1080

tatgccccac cacgcgactt cgcagcctat cgctcagcag gagcgcagac gctcccgcgt     1140

accagcaggg ccagaaccag ctctataacg agctcaatct aggacgaaga gaggagtacg     1200

atgttttgga caagagacgt ggccgggacc ctgagatggg aggcaagccg agaaggaaga     1260

accctcagga aggcctgtac aatgaactgc agaaagataa gatggcggag gcctacagtg     1320

agattgggat gaaaggcgag cgccggaggg gcaaggggca cgatggcctt taccagggtc     1380

tcagtacagc caccaaggac acctacgacg cccttcacat gcaggccctg cctcctcgc      1439


<210>  8
<211>  240
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic construct

<400>  8

Glu Ile Gln Leu Val Gln Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Val Arg Ile Ser Cys Ala Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Gly Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr His Thr Gly Glu Pro Thr Tyr Ala Asp Ser Phe 
    50                  55                  60                  


Lys Gly Arg Phe Thr Phe Ser Leu Asp Asp Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Ile Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      


Thr Arg Arg Gly Tyr Asp Trp Tyr Phe Asp Val Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu 
    130                 135                 140                 


Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln 
145                 150                 155                 160 


Asp Ile Asn Ser Tyr Leu Ser Trp Phe Gln Gln Lys Pro Gly Lys Ala 
                165                 170                 175     


Pro Lys Thr Leu Ile Tyr Arg Ala Asn Arg Leu Glu Ser Gly Val Pro 
            180                 185                 190         


Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile 
        195                 200                 205             


Ser Ser Leu Gln Tyr Glu Asp Phe Gly Ile Tyr Tyr Cys Gln Gln Tyr 
    210                 215                 220                 


Asp Glu Ser Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
225                 230                 235                 240 


<210>  9
<211>  401
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic construct

<400>  9
gactcttcgc gatgtacggg ccagatatac gcgtaaggtc gggcaggaag agggcctatt       60

tcccatgatt ccttcatatt tgcatatacg atacaaggct gttagagaga taattagaat      120

taatttgact gtaaacacaa agatattagt acaaaatacg tgacgtagaa agtaataatt      180

tcttgggtag tttgcagttt taaaattatg ttttaaaatg gactatcata tgcttaccgt      240

aacttgaaag tatttcgatt tcttggcttt atatatcttg tggaaaggac gaaacaccga      300

gcggttgcag agaccccatg ttttagagct agaaatagca agttaaaata aggctagtcc      360

gttatcaact tgaaaaagtg gcaccgagtc ggtgcttttt t                          401


<210>  10
<211>  80
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic construct

<400>  10
accatgccca tggggtctct gcaaccgctg gccaccttgt acctgctggg gatgctggtc       60

gcttcctgcc tcggacggct                                                   80


