			SEQUENCE LISTING

<110> CODEXIS, INC.
 
<120> ENGINEERED TRANSAMINASE POLYPEPTIDES FOR INDUSTRIAL BIOCATALYSIS
 
<130> CX2-167USP1
 
<140> NOT YET ASSIGNED
<141> SUBMITTED HEREWITH
 
<160> 172
 
<210> 1
<211> 1362
<212> DNA
<213> Artificial Sequence
 
<220>
<223> variant of transaminase from Vibrio fluvialis Js17
 
<400> 1
atgaacaaac cgcagagttg ggaagcgcgt gcggaaacct atagcctgta tggctttacc 60
gatatgccga gcctgcatca gcgtggcacc gtggtggtga cccatggcga aggcccgtat 120
atcgtggatg tgaacggccg tcgttatctg gatgcgaaca gcggcctgtg gaacatggtg 180
gcgggctttg atcataaagg cctgattgat gcggcgaaag cgcagtatga acgttttccg 240
ggctatcatg cgttttttgg ccgtatgagc gatcagaccg tgatgttgtc tgaaaaactg 300
gtggaagtga gcccgtttga tagcggccgt gtgttttata ccaacagcgg cagcgaagcg 360
aacgatacca tggtgaaaat gctgtggttt ctgcatgcgg cggaaggcaa accgcagaaa 420
cgtaaaattc tgacccgttg gaacgcgtat catggcgtga ccgcggtgag cgcgagcatg 480
accggcaaac cgtataacag cgtgtttggc ctgccgctgc cgggctttgt gcatctgacc 540
tgcccgcatt attggcgtta tggcgaagaa ggcgaaaccg aagaacagtt tgtggcgcgt 600
ctggcccgtg aactggaaga aaccattcag cgtgaaggcg cggataccat tgcgggcttt 660
tttgcggaac cggtgatggg tgcgggcggt gttattccgc cggcgaaagg ctattttcag 720
gcgattctgc cgatcctgcg caaatatgat attccggtga tcagcgatga agtgatttgc 780
ggctttggcc gtaccggcaa cacctggggc tgcgtgacct atgattttac cccggatgcg 840
attattagca gcaaaaacct gaccgcgggt ttttttccga tgggcgcggt gattctgggt 900
ccggaactga gcaaacgtct ggaaaccgcg attgaagcga tcgaagaatt tccgcatggt 960
tttaccgcga gcggccatcc ggtgggttgt gcgattgcgc tgaaagcgat tgatgtggtg 1020
atgaacgaag gcctggccga aaacgtgcgt cgtctggccc cgcgttttga agaacgtctg 1080
aaacatattg cggaacgtcc gaacattggc gaatatcgtg gcattggctt tatgtgggcg 1140
ctggaagcgg tgaaagataa agcgagcaaa accccgtttg atggcaacct gagcgtgagc 1200
gaacgtattg cgaacacctg caccgatctg ggcctgattt gccgtccgct gggccagagc 1260
gtggttctgt gcccgccgtt tattctgacc gaagcgcaga tggatgaaat gttcgataaa 1320
ctggaaaaag cgctggataa agtgtttgcg gaagtggcgt aa                    1362

 
<210> 2
<211> 453
<212> PRT
<213> Artificial Sequence
 
<220>
<223> variant of transaminase from Vibrio fluvialis Js17
 
<400> 2
Met Asn Lys Pro Gln Ser Trp Glu Ala Arg Ala Glu Thr Tyr Ser Leu 
1               5                   10                  15      
Tyr Gly Phe Thr Asp Met Pro Ser Leu His Gln Arg Gly Thr Val Val 
            20                  25                  30          
Val Thr His Gly Glu Gly Pro Tyr Ile Val Asp Val Asn Gly Arg Arg 
        35                  40                  45              
Tyr Leu Asp Ala Asn Ser Gly Leu Trp Asn Met Val Ala Gly Phe Asp 
    50                  55                  60                  
His Lys Gly Leu Ile Asp Ala Ala Lys Ala Gln Tyr Glu Arg Phe Pro 
65                  70                  75                  80  
Gly Tyr His Ala Phe Phe Gly Arg Met Ser Asp Gln Thr Val Met Leu 
                85                  90                  95      
Ser Glu Lys Leu Val Glu Val Ser Pro Phe Asp Ser Gly Arg Val Phe 
            100                 105                 110         
Tyr Thr Asn Ser Gly Ser Glu Ala Asn Asp Thr Met Val Lys Met Leu 
        115                 120                 125             
Trp Phe Leu His Ala Ala Glu Gly Lys Pro Gln Lys Arg Lys Ile Leu 
    130                 135                 140                 
Thr Arg Trp Asn Ala Tyr His Gly Val Thr Ala Val Ser Ala Ser Met 
145                 150                 155                 160 
Thr Gly Lys Pro Tyr Asn Ser Val Phe Gly Leu Pro Leu Pro Gly Phe 
                165                 170                 175     
Val His Leu Thr Cys Pro His Tyr Trp Arg Tyr Gly Glu Glu Gly Glu 
            180                 185                 190         
Thr Glu Glu Gln Phe Val Ala Arg Leu Ala Arg Glu Leu Glu Glu Thr 
        195                 200                 205             
Ile Gln Arg Glu Gly Ala Asp Thr Ile Ala Gly Phe Phe Ala Glu Pro 
    210                 215                 220                 
Val Met Gly Ala Gly Gly Val Ile Pro Pro Ala Lys Gly Tyr Phe Gln 
225                 230                 235                 240 
Ala Ile Leu Pro Ile Leu Arg Lys Tyr Asp Ile Pro Val Ile Ser Asp 
                245                 250                 255     
Glu Val Ile Cys Gly Phe Gly Arg Thr Gly Asn Thr Trp Gly Cys Val 
            260                 265                 270         
Thr Tyr Asp Phe Thr Pro Asp Ala Ile Ile Ser Ser Lys Asn Leu Thr 
        275                 280                 285             
Ala Gly Phe Phe Pro Met Gly Ala Val Ile Leu Gly Pro Glu Leu Ser 
    290                 295                 300                 
Lys Arg Leu Glu Thr Ala Ile Glu Ala Ile Glu Glu Phe Pro His Gly 
305                 310                 315                 320 
Phe Thr Ala Ser Gly His Pro Val Gly Cys Ala Ile Ala Leu Lys Ala 
                325                 330                 335     
Ile Asp Val Val Met Asn Glu Gly Leu Ala Glu Asn Val Arg Arg Leu 
            340                 345                 350         
Ala Pro Arg Phe Glu Glu Arg Leu Lys His Ile Ala Glu Arg Pro Asn 
        355                 360                 365             
Ile Gly Glu Tyr Arg Gly Ile Gly Phe Met Trp Ala Leu Glu Ala Val 
    370                 375                 380                 
Lys Asp Lys Ala Ser Lys Thr Pro Phe Asp Gly Asn Leu Ser Val Ser 
385                 390                 395                 400 
Glu Arg Ile Ala Asn Thr Cys Thr Asp Leu Gly Leu Ile Cys Arg Pro 
                405                 410                 415     
Leu Gly Gln Ser Val Val Leu Cys Pro Pro Phe Ile Leu Thr Glu Ala 
            420                 425                 430         
Gln Met Asp Glu Met Phe Asp Lys Leu Glu Lys Ala Leu Asp Lys Val 
        435                 440                 445             
Phe Ala Glu Val Ala                                             
    450                                                         

 
<210> 3
<211> 1359
<212> DNA
<213> Artificial Sequence
 
<220>
<223> variant of transaminase from Vibrio fluvialis Js17
 
<400> 3
atgaacaaac cgcagagctg ggaaacgcgt gcggaaacct atagcctgta tggttttacc 60
gatatgccga gcctgcatca gcgtggcacc gtggtggtga cccatggcga aggcccgtat 120
atcgtggatg tgcatggccg tcgttatctg gatgcgaaca gcggcgctct gaacatggtg 180
gcgggctttg atcataaagg cctgattgat gcggcgaaaa cgcagtatga acgttttccg 240
ggctatcatg cgtttagcgg ccgtatgagc gatcagaccg tgatgctgtc tgaaaaactg 300
gtggaagtga gcccgtttga tagcggccgt gtgttttata ccaacagcgg cagcgaagcg 360
aacgatacca tggtgaaaat gctgtggttt ctgcatgcgg cggaaggcaa accgcagaaa 420
cgtaaaattc tgacccgttg gaacgcgtat catggcgcga ccgcggtgag cgcgagcatg 480
accggctttc cgtataacag cgtgtttggc ctgccgctgc cgggctttct gcatctgacc 540
tgcccgcatt attggcgtta tggcgaagaa ggcgaaaccg aagaacagtt tgtcgcgcgt 600
ctggcccgtg aactggaaga aaccattcag aaggaaggcg cggataccat tgcgggcttt 660
tttgcggaac cggtgatggg tgcgggcggt gttattccgc cggcaaaagg ctattttcag 720
gcgattctgc cgatcctgcg caaatatgat attccggtga tcagcgatga agtgatttgc 780
ggcttcggcc gtaccggtaa cacctggggc tgcgtgacct atgattttac cccggatgcg 840
attattagca gtaaaagcct aaccgcgggt ttttttccgg taggcgcggt gattctgggt 900
ccggaactga gcaaacgtct ggaaaccgcg attgaagcga tcgaagaatt tccgcatggt 960
tttaccacag gcggccatcc ggtgggttgt gcgattgcgc tgaaagcgat tgatgtggtg 1020
atgaacgaag gcctggccga aaacgtgcgt cgtctggccc cgcgttttga agaacgtctg 1080
aaacatattg cggaacgtcc gaacattggc gaatatcgtg gcattggctt tatgtgggcg 1140
ctggaagtcg tgaaagataa agcgagcaaa gccccgtttg gtggcaacct gagcgtgagc 1200
gaacgtattg cgaacacctg caccgatctg ggcctgattt gccgtccgct gggccagagc 1260
gtggttctgt gcccgccgtt tattctgacc gaagcgcaga tggatgaaat gttcgataaa 1320
ctggaaaaag cgctggataa agtgttcgcg gaagtggcg                        1359

 
<210> 4
<211> 453
<212> PRT
<213> Artificial Sequence
 
<220>
<223> variant of transaminase from Vibrio fluvialis Js17
 
<400> 4
Met Asn Lys Pro Gln Ser Trp Glu Thr Arg Ala Glu Thr Tyr Ser Leu 
1               5                   10                  15      
Tyr Gly Phe Thr Asp Met Pro Ser Leu His Gln Arg Gly Thr Val Val 
            20                  25                  30          
Val Thr His Gly Glu Gly Pro Tyr Ile Val Asp Val His Gly Arg Arg 
        35                  40                  45              
Tyr Leu Asp Ala Asn Ser Gly Ala Leu Asn Met Val Ala Gly Phe Asp 
    50                  55                  60                  
His Lys Gly Leu Ile Asp Ala Ala Lys Thr Gln Tyr Glu Arg Phe Pro 
65                  70                  75                  80  
Gly Tyr His Ala Phe Ser Gly Arg Met Ser Asp Gln Thr Val Met Leu 
                85                  90                  95      
Ser Glu Lys Leu Val Glu Val Ser Pro Phe Asp Ser Gly Arg Val Phe 
            100                 105                 110         
Tyr Thr Asn Ser Gly Ser Glu Ala Asn Asp Thr Met Val Lys Met Leu 
        115                 120                 125             
Trp Phe Leu His Ala Ala Glu Gly Lys Pro Gln Lys Arg Lys Ile Leu 
    130                 135                 140                 
Thr Arg Trp Asn Ala Tyr His Gly Ala Thr Ala Val Ser Ala Ser Met 
145                 150                 155                 160 
Thr Gly Phe Pro Tyr Asn Ser Val Phe Gly Leu Pro Leu Pro Gly Phe 
                165                 170                 175     
Leu His Leu Thr Cys Pro His Tyr Trp Arg Tyr Gly Glu Glu Gly Glu 
            180                 185                 190         
Thr Glu Glu Gln Phe Val Ala Arg Leu Ala Arg Glu Leu Glu Glu Thr 
        195                 200                 205             
Ile Gln Lys Glu Gly Ala Asp Thr Ile Ala Gly Phe Phe Ala Glu Pro 
    210                 215                 220                 
Val Met Gly Ala Gly Gly Val Ile Pro Pro Ala Lys Gly Tyr Phe Gln 
225                 230                 235                 240 
Ala Ile Leu Pro Ile Leu Arg Lys Tyr Asp Ile Pro Val Ile Ser Asp 
                245                 250                 255     
Glu Val Ile Cys Gly Phe Gly Arg Thr Gly Asn Thr Trp Gly Cys Val 
            260                 265                 270         
Thr Tyr Asp Phe Thr Pro Asp Ala Ile Ile Ser Ser Lys Ser Leu Thr 
        275                 280                 285             
Ala Gly Phe Phe Pro Val Gly Ala Val Ile Leu Gly Pro Glu Leu Ser 
    290                 295                 300                 
Lys Arg Leu Glu Thr Ala Ile Glu Ala Ile Glu Glu Phe Pro His Gly 
305                 310                 315                 320 
Phe Thr Thr Gly Gly His Pro Val Gly Cys Ala Ile Ala Leu Lys Ala 
                325                 330                 335     
Ile Asp Val Val Met Asn Glu Gly Leu Ala Glu Asn Val Arg Arg Leu 
            340                 345                 350         
Ala Pro Arg Phe Glu Glu Arg Leu Lys His Ile Ala Glu Arg Pro Asn 
        355                 360                 365             
Ile Gly Glu Tyr Arg Gly Ile Gly Phe Met Trp Ala Leu Glu Val Val 
    370                 375                 380                 
Lys Asp Lys Ala Ser Lys Ala Pro Phe Gly Gly Asn Leu Ser Val Ser 
385                 390                 395                 400 
Glu Arg Ile Ala Asn Thr Cys Thr Asp Leu Gly Leu Ile Cys Arg Pro 
                405                 410                 415     
Leu Gly Gln Ser Val Val Leu Cys Pro Pro Phe Ile Leu Thr Glu Ala 
            420                 425                 430         
Gln Met Asp Glu Met Phe Asp Lys Leu Glu Lys Ala Leu Asp Lys Val 
        435                 440                 445             
Phe Ala Glu Val Ala                                             
    450                                                         

 
<210> 5
<211> 1359
<212> DNA
<213> Artificial Sequence
 
<220>
<223> variant of transaminase from Vibrio fluvialis Js17
 
<400> 5
atgaacaaac cgcagagctg ggaaacgcgt gcggaaacct atagcctgta tggttttacc 60
gatatgccga gcctgcatca gcgtggcacc gtggtggtga cccatggcga aggcccgtat 120
atcgtggatg tgcatggccg tcgttatctg gatgcgaaca gcggcgctct gaacatggtg 180
gcgggctttg atcataaagg cctgattgat gcggcgaaaa cgcagtatga acgttttccg 240
ggctatcatg cgtttagcgg ccgtatgagc gatcagaccg tgatgctgtc tgaaaaactg 300
gtggaagtga gcccgtttga tagcggccgt gtgttttata ccaacagcgg cagcgaagcg 360
aacgatacca tggtgaaaat gctgtggttt ctgcatgcgg cggaaggcaa accgcagaaa 420
cgtaaaattc tgacccgttg gaacgcgtat catggcgcga ccgcggtgag cgcgagcatg 480
accggctttc cgtataacag cgtgtttggc ctgccgctgc cgggctttct gcatctgacc 540
tgcccgcatt attggcgtta tggcgaagaa ggcgaaaccg aagaacagtt tgtcgcgcgt 600
ctggcccgtg aactggaaga aaccattcag aaggaaggcg cggataccat tgcgggcttt 660
tttgcggaac cggtgatggg tgcgggcggt gttattccgc cggcaaaagg ctattttcag 720
gcgattctgc cgatcctgcg caaatatgat attccggtga tcagcgatga agtgatttgc 780
ggcttcggcc gtaccggtaa cacctggggc tgcgtgacct atgattttac cccggatgcg 840
attattagca gtaaaagcct aaccgcgggt ttttttccgg taggcgcggt gattctgggt 900
ccggaactga gcaaacgtct ggaaaccgcg attgaagcga tcgaagaatt tccggtgggt 960
tttaccacag gcggccatcc ggtgggttgt gcgattgcgc tgaaagcgat tgatgtggtg 1020
atgaacgaag gcctggccga aaacgtgcgt cgtctggccc cgcgttttga agaacgtctg 1080
aaacatattg cggaacgtcc gaacattggc gaatatcgtg gcattggctt tatgtgggcg 1140
ctggaagtcg tgaaagataa agcgagcaaa gccccgtttg gtggcaacct gagcgtgagc 1200
gaacgtattg cgaacacctg caccgatctg ggcctgattt gccgtccgct gggccagagc 1260
gtggttctgt gcccgccgtt tattctgacc gaagcgcaga tggatgaaat gttcgataaa 1320
ctggaaaaag cgctggataa agtgttcgcg gaagtggcg                        1359

 
<210> 6
<211> 453
<212> PRT
<213> Artificial Sequence
 
<220>
<223> variant of transaminase from Vibrio fluvialis Js17
 
<400> 6
Met Asn Lys Pro Gln Ser Trp Glu Thr Arg Ala Glu Thr Tyr Ser Leu 
1               5                   10                  15      
Tyr Gly Phe Thr Asp Met Pro Ser Leu His Gln Arg Gly Thr Val Val 
            20                  25                  30          
Val Thr His Gly Glu Gly Pro Tyr Ile Val Asp Val His Gly Arg Arg 
        35                  40                  45              
Tyr Leu Asp Ala Asn Ser Gly Ala Leu Asn Met Val Ala Gly Phe Asp 
    50                  55                  60                  
His Lys Gly Leu Ile Asp Ala Ala Lys Thr Gln Tyr Glu Arg Phe Pro 
65                  70                  75                  80  
Gly Tyr His Ala Phe Ser Gly Arg Met Ser Asp Gln Thr Val Met Leu 
                85                  90                  95      
Ser Glu Lys Leu Val Glu Val Ser Pro Phe Asp Ser Gly Arg Val Phe 
            100                 105                 110         
Tyr Thr Asn Ser Gly Ser Glu Ala Asn Asp Thr Met Val Lys Met Leu 
        115                 120                 125             
Trp Phe Leu His Ala Ala Glu Gly Lys Pro Gln Lys Arg Lys Ile Leu 
    130                 135                 140                 
Thr Arg Trp Asn Ala Tyr His Gly Ala Thr Ala Val Ser Ala Ser Met 
145                 150                 155                 160 
Thr Gly Phe Pro Tyr Asn Ser Val Phe Gly Leu Pro Leu Pro Gly Phe 
                165                 170                 175     
Leu His Leu Thr Cys Pro His Tyr Trp Arg Tyr Gly Glu Glu Gly Glu 
            180                 185                 190         
Thr Glu Glu Gln Phe Val Ala Arg Leu Ala Arg Glu Leu Glu Glu Thr 
        195                 200                 205             
Ile Gln Lys Glu Gly Ala Asp Thr Ile Ala Gly Phe Phe Ala Glu Pro 
    210                 215                 220                 
Val Met Gly Ala Gly Gly Val Ile Pro Pro Ala Lys Gly Tyr Phe Gln 
225                 230                 235                 240 
Ala Ile Leu Pro Ile Leu Arg Lys Tyr Asp Ile Pro Val Ile Ser Asp 
                245                 250                 255     
Glu Val Ile Cys Gly Phe Gly Arg Thr Gly Asn Thr Trp Gly Cys Val 
            260                 265                 270         
Thr Tyr Asp Phe Thr Pro Asp Ala Ile Ile Ser Ser Lys Ser Leu Thr 
        275                 280                 285             
Ala Gly Phe Phe Pro Val Gly Ala Val Ile Leu Gly Pro Glu Leu Ser 
    290                 295                 300                 
Lys Arg Leu Glu Thr Ala Ile Glu Ala Ile Glu Glu Phe Pro Val Gly 
305                 310                 315                 320 
Phe Thr Thr Gly Gly His Pro Val Gly Cys Ala Ile Ala Leu Lys Ala 
                325                 330                 335     
Ile Asp Val Val Met Asn Glu Gly Leu Ala Glu Asn Val Arg Arg Leu 
            340                 345                 350         
Ala Pro Arg Phe Glu Glu Arg Leu Lys His Ile Ala Glu Arg Pro Asn 
        355                 360                 365             
Ile Gly Glu Tyr Arg Gly Ile Gly Phe Met Trp Ala Leu Glu Val Val 
    370                 375                 380                 
Lys Asp Lys Ala Ser Lys Ala Pro Phe Gly Gly Asn Leu Ser Val Ser 
385                 390                 395                 400 
Glu Arg Ile Ala Asn Thr Cys Thr Asp Leu Gly Leu Ile Cys Arg Pro 
                405                 410                 415     
Leu Gly Gln Ser Val Val Leu Cys Pro Pro Phe Ile Leu Thr Glu Ala 
            420                 425                 430         
Gln Met Asp Glu Met Phe Asp Lys Leu Glu Lys Ala Leu Asp Lys Val 
        435                 440                 445             
Phe Ala Glu Val Ala                                             
    450                                                         

 
<210> 7
<211> 1359
<212> DNA
<213> Artificial Sequence
 
<220>
<223> variant of transaminase from Vibrio fluvialis Js17
 
<400> 7
atgaacaaac cgcagagctg ggaaacgcgt gcggaaacct atagcctgta tggttttacc 60
gatatgccga gcctgcatca gcgtggcacc gtggtggtga cccatggcga aggcccgtat 120
atcgtggatg tgcatggccg tcgttatctg gatgcgaaca gcggcgctct gaacatggtg 180
gcgggctttg atcataaagg cctgattgat gcggcgaaaa cgcagtatga acgttttccg 240
ggctatcatg cgtttagcgg ccgtatgagc gatcagaccg tgatgctgtc tgaaaaactg 300
gtggaagtga gcccgtttga tagcggccgt gtgttttata ccaacagcgg cagcgaagcg 360
aacgatacca tggtgaaaat gctgtggttt ctgcatgcgg cggaaggcaa accgcagaaa 420
cgtaaaattc tgacccgttg gaacgcgtat catggcgcga ccgcggtgag cgcgagcatg 480
accggctttc cgtataacag cgtgtttggc ctgccgctgc cgggctttct gcatctgacc 540
tgcccgcatt attggcgtta tggcgaagaa ggcgaaaccg aagaacagtt tgtcgcgcgt 600
ctggcccgtg aactggaaga aaccattcag aaggaaggcg cggataccat tgcgggcttt 660
tttgcggaac cggtgatggg tgcgggcggt gttattccgc cggcaaaagg ctattttcag 720
gcgattctgc cgatcctgcg caaatatgat attccggtga tcagcgatga agtgatttgc 780
ggcttcggcc gtaccggtaa cacctggggc tgcgtgacct atgattttac cccggatgcg 840
attattagca gtaaaagcct aaccgcgggt ttttttccgg taggcgcggt gattctgggt 900
ccggaactga gcaaacgtct ggaaaccgcg attgaagcga tcgaagaatt tccgcttggt 960
tttaccacag gcggccatcc ggtgggttgt gcgattgcgc tgaaagcgat tgatgtggtg 1020
atgaacgaag gcctggccga aaacgtgcgt cgtctggccc cgcgttttga agaacgtctg 1080
aaacatattg cggaacgtcc gaacattggc gaatatcgtg gcattggctt tatgtgggcg 1140
ctggaagtcg tgaaagataa agcgagcaaa gccccgtttg gtggcaacct gagcgtgagc 1200
gaacgtattg cgaacacctg caccgatctg ggcctgattt gccgtccgct gggccagagc 1260
gtggttctgt gcccgccgtt tattctgacc gaagcgcaga tggatgaaat gttcgataaa 1320
ctggaaaaag cgctggataa agtgttcgcg gaagtggcg                        1359

 
<210> 8
<211> 453
<212> PRT
<213> Artificial Sequence
 
<220>
<223> variant of transaminase from Vibrio fluvialis Js17
 
<400> 8
Met Asn Lys Pro Gln Ser Trp Glu Thr Arg Ala Glu Thr Tyr Ser Leu 
1               5                   10                  15      
Tyr Gly Phe Thr Asp Met Pro Ser Leu His Gln Arg Gly Thr Val Val 
            20                  25                  30          
Val Thr His Gly Glu Gly Pro Tyr Ile Val Asp Val His Gly Arg Arg 
        35                  40                  45              
Tyr Leu Asp Ala Asn Ser Gly Ala Leu Asn Met Val Ala Gly Phe Asp 
    50                  55                  60                  
His Lys Gly Leu Ile Asp Ala Ala Lys Thr Gln Tyr Glu Arg Phe Pro 
65                  70                  75                  80  
Gly Tyr His Ala Phe Ser Gly Arg Met Ser Asp Gln Thr Val Met Leu 
                85                  90                  95      
Ser Glu Lys Leu Val Glu Val Ser Pro Phe Asp Ser Gly Arg Val Phe 
            100                 105                 110         
Tyr Thr Asn Ser Gly Ser Glu Ala Asn Asp Thr Met Val Lys Met Leu 
        115                 120                 125             
Trp Phe Leu His Ala Ala Glu Gly Lys Pro Gln Lys Arg Lys Ile Leu 
    130                 135                 140                 
Thr Arg Trp Asn Ala Tyr His Gly Ala Thr Ala Val Ser Ala Ser Met 
145                 150                 155                 160 
Thr Gly Phe Pro Tyr Asn Ser Val Phe Gly Leu Pro Leu Pro Gly Phe 
                165                 170                 175     
Leu His Leu Thr Cys Pro His Tyr Trp Arg Tyr Gly Glu Glu Gly Glu 
            180                 185                 190         
Thr Glu Glu Gln Phe Val Ala Arg Leu Ala Arg Glu Leu Glu Glu Thr 
        195                 200                 205             
Ile Gln Lys Glu Gly Ala Asp Thr Ile Ala Gly Phe Phe Ala Glu Pro 
    210                 215                 220                 
Val Met Gly Ala Gly Gly Val Ile Pro Pro Ala Lys Gly Tyr Phe Gln 
225                 230                 235                 240 
Ala Ile Leu Pro Ile Leu Arg Lys Tyr Asp Ile Pro Val Ile Ser Asp 
                245                 250                 255     
Glu Val Ile Cys Gly Phe Gly Arg Thr Gly Asn Thr Trp Gly Cys Val 
            260                 265                 270         
Thr Tyr Asp Phe Thr Pro Asp Ala Ile Ile Ser Ser Lys Ser Leu Thr 
        275                 280                 285             
Ala Gly Phe Phe Pro Val Gly Ala Val Ile Leu Gly Pro Glu Leu Ser 
    290                 295                 300                 
Lys Arg Leu Glu Thr Ala Ile Glu Ala Ile Glu Glu Phe Pro Leu Gly 
305                 310                 315                 320 
Phe Thr Thr Gly Gly His Pro Val Gly Cys Ala Ile Ala Leu Lys Ala 
                325                 330                 335     
Ile Asp Val Val Met Asn Glu Gly Leu Ala Glu Asn Val Arg Arg Leu 
            340                 345                 350         
Ala Pro Arg Phe Glu Glu Arg Leu Lys His Ile Ala Glu Arg Pro Asn 
        355                 360                 365             
Ile Gly Glu Tyr Arg Gly Ile Gly Phe Met Trp Ala Leu Glu Val Val 
    370                 375                 380                 
Lys Asp Lys Ala Ser Lys Ala Pro Phe Gly Gly Asn Leu Ser Val Ser 
385                 390                 395                 400 
Glu Arg Ile Ala Asn Thr Cys Thr Asp Leu Gly Leu Ile Cys Arg Pro 
                405                 410                 415     
Leu Gly Gln Ser Val Val Leu Cys Pro Pro Phe Ile Leu Thr Glu Ala 
            420                 425                 430         
Gln Met Asp Glu Met Phe Asp Lys Leu Glu Lys Ala Leu Asp Lys Val 
        435                 440                 445             
Phe Ala Glu Val Ala                                             
    450                                                         

 
<210> 9
<211> 1359
<212> DNA
<213> Artificial Sequence
 
<220>
<223> variant of transaminase from Vibrio fluvialis Js17
 
<400> 9
atgaacaaac cgcagagctg ggaaacgcgt gcggaaacct atagcctgta tggttttacc 60
gatatgccga gcctgcatca gcgtggcacc gtggtggtga cccatggcga aggcccgtat 120
atcgtggatg tgcatggccg tcgttatctg gatgcgaaca gcggcgctct gaacatggtg 180
gcgggctttg atcataaagg cctgattgat gcggcgaaaa cgcagtatga acgttttccg 240
ggctatcatg cgtttagcgg ccgtatgagc gatcagaccg tgatgctgtc tgaaaaactg 300
gtggaagtga gcccgtttga tagcggccgt gtgttttata ccaacagcgg cagcgaagcg 360
aacgatacca tggtgaaaat gctgtggttt ctgcatgcgg cggaaggcaa accgcagaaa 420
cgtaaaattc tgacccgttg gaacgcgtat catggcgcga ccgcggtgag cgcgagcatg 480
accggctttc cgtataacag cgtgtttggc ctgccgctgc cgggctttct gcatctgacc 540
tgcccgcatt attggcgtta tggcgaagaa ggcgaaaccg aagaacagtt tgtcgcgcgt 600
ctggcccgtg aactggaaga aaccattcag aaggaaggcg cggataccat tgcgggcttt 660
tttgcggaac cggtgatggg tgcgggcggt gttattccgc cggcaaaagg ctattttcag 720
gcgattctgc cgatcctgcg caaatatgat attccggtga tcagcgatga agtgatttgc 780
ggcttcggcc gtaccggtaa cacctggggc tgcgtgacct atgattttac cccggatgcg 840
attattagca gtaaaagcct aaccgcgggt ttttttccgg taggcgcggt gattctgggt 900
ccggaactga gcaaacgtct ggaaaccgcg attgaagcga tcgaagaatt tccgcatggt 960
tttaccacag gcggccatcc ggtgggttgt gcgattgcgc tgaaagcgat tgatgtggtg 1020
atgaacgaag gcctggccga aaacgtgcgt cgtctggccc cgcgttttga agaacgtctg 1080
aaacatattg cggaacgtcc gaacattggc gaatatcgtg gcattggctt tatgtgggcg 1140
ctggaagtcg tgaaagataa agcgagcaaa gccccgtttg gtggcaacct gagcgtgagc 1200
gaacgtattg cgaacacctg caccgatctg ggcctgattt gccgtccggg gggccagagc 1260
gtggttctgt gcccgccgtt tattctgacc gaagcgcaga tggatgaaat gttcgataaa 1320
ctggaaaaag cgctggataa agtgttcgcg gaagtggcg                        1359

 
<210> 10
<211> 453
<212> PRT
<213> Artificial Sequence
 
<220>
<223> variant of transaminase from Vibrio fluvialis Js17
 
<400> 10
Met Asn Lys Pro Gln Ser Trp Glu Thr Arg Ala Glu Thr Tyr Ser Leu 
1               5                   10                  15      
Tyr Gly Phe Thr Asp Met Pro Ser Leu His Gln Arg Gly Thr Val Val 
            20                  25                  30          
Val Thr His Gly Glu Gly Pro Tyr Ile Val Asp Val His Gly Arg Arg 
        35                  40                  45              
Tyr Leu Asp Ala Asn Ser Gly Ala Leu Asn Met Val Ala Gly Phe Asp 
    50                  55                  60                  
His Lys Gly Leu Ile Asp Ala Ala Lys Thr Gln Tyr Glu Arg Phe Pro 
65                  70                  75                  80  
Gly Tyr His Ala Phe Ser Gly Arg Met Ser Asp Gln Thr Val Met Leu 
                85                  90                  95      
Ser Glu Lys Leu Val Glu Val Ser Pro Phe Asp Ser Gly Arg Val Phe 
            100                 105                 110         
Tyr Thr Asn Ser Gly Ser Glu Ala Asn Asp Thr Met Val Lys Met Leu 
        115                 120                 125             
Trp Phe Leu His Ala Ala Glu Gly Lys Pro Gln Lys Arg Lys Ile Leu 
    130                 135                 140                 
Thr Arg Trp Asn Ala Tyr His Gly Ala Thr Ala Val Ser Ala Ser Met 
145                 150                 155                 160 
Thr Gly Phe Pro Tyr Asn Ser Val Phe Gly Leu Pro Leu Pro Gly Phe 
                165                 170                 175     
Leu His Leu Thr Cys Pro His Tyr Trp Arg Tyr Gly Glu Glu Gly Glu 
            180                 185                 190         
Thr Glu Glu Gln Phe Val Ala Arg Leu Ala Arg Glu Leu Glu Glu Thr 
        195                 200                 205             
Ile Gln Lys Glu Gly Ala Asp Thr Ile Ala Gly Phe Phe Ala Glu Pro 
    210                 215                 220                 
Val Met Gly Ala Gly Gly Val Ile Pro Pro Ala Lys Gly Tyr Phe Gln 
225                 230                 235                 240 
Ala Ile Leu Pro Ile Leu Arg Lys Tyr Asp Ile Pro Val Ile Ser Asp 
                245                 250                 255     
Glu Val Ile Cys Gly Phe Gly Arg Thr Gly Asn Thr Trp Gly Cys Val 
            260                 265                 270         
Thr Tyr Asp Phe Thr Pro Asp Ala Ile Ile Ser Ser Lys Ser Leu Thr 
        275                 280                 285             
Ala Gly Phe Phe Pro Val Gly Ala Val Ile Leu Gly Pro Glu Leu Ser 
    290                 295                 300                 
Lys Arg Leu Glu Thr Ala Ile Glu Ala Ile Glu Glu Phe Pro His Gly 
305                 310                 315                 320 
Phe Thr Thr Gly Gly His Pro Val Gly Cys Ala Ile Ala Leu Lys Ala 
                325                 330                 335     
Ile Asp Val Val Met Asn Glu Gly Leu Ala Glu Asn Val Arg Arg Leu 
            340                 345                 350         
Ala Pro Arg Phe Glu Glu Arg Leu Lys His Ile Ala Glu Arg Pro Asn 
        355                 360                 365             
Ile Gly Glu Tyr Arg Gly Ile Gly Phe Met Trp Ala Leu Glu Val Val 
    370                 375                 380                 
Lys Asp Lys Ala Ser Lys Ala Pro Phe Gly Gly Asn Leu Ser Val Ser 
385                 390                 395                 400 
Glu Arg Ile Ala Asn Thr Cys Thr Asp Leu Gly Leu Ile Cys Arg Pro 
                405                 410                 415     
Gly Gly Gln Ser Val Val Leu Cys Pro Pro Phe Ile Leu Thr Glu Ala 
            420                 425                 430         
Gln Met Asp Glu Met Phe Asp Lys Leu Glu Lys Ala Leu Asp Lys Val 
        435                 440                 445             
Phe Ala Glu Val Ala                                             
    450                                                         

 
<210> 11
<211> 1359
<212> DNA
<213> Artificial Sequence
 
<220>
<223> variant of transaminase from Vibrio fluvialis Js17
 
<400> 11
atgaacaaac cgcagagctg ggaaacgcgt gcggaaacct atagcctgta tggttttacc 60
gatatgccga gcctgcatca gcgtggcacc gtggtggtga cccatggcga aggcccgtat 120
atcgtggatg tgcatggccg tcgttatctg gatgcgaaca gcggcgctac taacatggtg 180
gcgggctttg atcataaagg cctgattgat gcggcgaaaa cgcagtatga acgttttccg 240
ggctatcatg cgtttagcgg ccgtatgagc gatcagaccg tgatgctgtc tgaaaaactg 300
gtggaagtga gcccgtttga tagcggccgt gtgttttata ccaacagcgg cagcgaagcg 360
aacgatacca tggtgaaaat gctgtggttt ctgcatgcgg cggaaggcaa accgcagaaa 420
cgtaaaattc tgacccgttg gaacgcgtat catggcgcga ccgcggtgag cgcgagcatg 480
accggctttc cgtataacag cgtgtttggc ctgccgctgc cgggctttct gcatctgacc 540
tgcccgcatt attggcgtta tggcgaagaa ggcgaaaccg aagaacagtt tgtcgcgcgt 600
ctggcccgtg aactggaaga aaccattcag aaggaaggcg cggataccat tgcgggcttt 660
tttgcggaac cggtgatggg tgcgggcggt gttattccgc cggcaaaagg ctattttcag 720
gcgattctgc cgatcctgcg caaatatgat attccggtga tcagcgatga agtgatttgc 780
ggcttcggcc gtaccggtaa cacctggggc tgcgtgacct atgattttac cccggatgcg 840
attattagca gtaaaagcct aaccgcgggt ttttttccgg taggcgcggt gattctgggt 900
ccggaactga gcaaacgtct ggaaaccgcg attgaagcga tcgaagaatt tccggagggt 960
tttaccacag gcggccatcc ggtgggttgt gcgattgcgc tgaaagcgat tgatgtggtg 1020
atgaacgaag gcctggccga aaacgtgcgt cgtctggccc cgcgttttga agaacgtctg 1080
aaacatattg cggaacgtcc gaacattggc gaatatcgtg gcattggctt tatgtgggcg 1140
ctggaagtcg tgaaagataa agcgagcaaa gccccgtttg gtggcaacct gagcgtgagc 1200
gaacgtattg cgaacacctg caccgatctg ggcctgattt gccgtccgct gggccagagc 1260
gtggttctgt gcccgccgtt tattctgacc gaagcgcaga tggatgaaat gttcgataaa 1320
ctggaaaaag cgctggataa agtgttcgcg gaagtggcg                        1359

 
<210> 12
<211> 453
<212> PRT
<213> Artificial Sequence
 
<220>
<223> variant of transaminase from Vibrio fluvialis Js17
 
<400> 12
Met Asn Lys Pro Gln Ser Trp Glu Thr Arg Ala Glu Thr Tyr Ser Leu 
1               5                   10                  15      
Tyr Gly Phe Thr Asp Met Pro Ser Leu His Gln Arg Gly Thr Val Val 
            20                  25                  30          
Val Thr His Gly Glu Gly Pro Tyr Ile Val Asp Val His Gly Arg Arg 
        35                  40                  45              
Tyr Leu Asp Ala Asn Ser Gly Ala Thr Asn Met Val Ala Gly Phe Asp 
    50                  55                  60                  
His Lys Gly Leu Ile Asp Ala Ala Lys Thr Gln Tyr Glu Arg Phe Pro 
65                  70                  75                  80  
Gly Tyr His Ala Phe Ser Gly Arg Met Ser Asp Gln Thr Val Met Leu 
                85                  90                  95      
Ser Glu Lys Leu Val Glu Val Ser Pro Phe Asp Ser Gly Arg Val Phe 
            100                 105                 110         
Tyr Thr Asn Ser Gly Ser Glu Ala Asn Asp Thr Met Val Lys Met Leu 
        115                 120                 125             
Trp Phe Leu His Ala Ala Glu Gly Lys Pro Gln Lys Arg Lys Ile Leu 
    130                 135                 140                 
Thr Arg Trp Asn Ala Tyr His Gly Ala Thr Ala Val Ser Ala Ser Met 
145                 150                 155                 160 
Thr Gly Phe Pro Tyr Asn Ser Val Phe Gly Leu Pro Leu Pro Gly Phe 
                165                 170                 175     
Leu His Leu Thr Cys Pro His Tyr Trp Arg Tyr Gly Glu Glu Gly Glu 
            180                 185                 190         
Thr Glu Glu Gln Phe Val Ala Arg Leu Ala Arg Glu Leu Glu Glu Thr 
        195                 200                 205             
Ile Gln Lys Glu Gly Ala Asp Thr Ile Ala Gly Phe Phe Ala Glu Pro 
    210                 215                 220                 
Val Met Gly Ala Gly Gly Val Ile Pro Pro Ala Lys Gly Tyr Phe Gln 
225                 230                 235                 240 
Ala Ile Leu Pro Ile Leu Arg Lys Tyr Asp Ile Pro Val Ile Ser Asp 
                245                 250                 255     
Glu Val Ile Cys Gly Phe Gly Arg Thr Gly Asn Thr Trp Gly Cys Val 
            260                 265                 270         
Thr Tyr Asp Phe Thr Pro Asp Ala Ile Ile Ser Ser Lys Ser Leu Thr 
        275                 280                 285             
Ala Gly Phe Phe Pro Val Gly Ala Val Ile Leu Gly Pro Glu Leu Ser 
    290                 295                 300                 
Lys Arg Leu Glu Thr Ala Ile Glu Ala Ile Glu Glu Phe Pro Glu Gly 
305                 310                 315                 320 
Phe Thr Thr Gly Gly His Pro Val Gly Cys Ala Ile Ala Leu Lys Ala 
                325                 330                 335     
Ile Asp Val Val Met Asn Glu Gly Leu Ala Glu Asn Val Arg Arg Leu 
            340                 345                 350         
Ala Pro Arg Phe Glu Glu Arg Leu Lys His Ile Ala Glu Arg Pro Asn 
        355                 360                 365             
Ile Gly Glu Tyr Arg Gly Ile Gly Phe Met Trp Ala Leu Glu Val Val 
    370                 375                 380                 
Lys Asp Lys Ala Ser Lys Ala Pro Phe Gly Gly Asn Leu Ser Val Ser 
385                 390                 395                 400 
Glu Arg Ile Ala Asn Thr Cys Thr Asp Leu Gly Leu Ile Cys Arg Pro 
                405                 410                 415     
Leu Gly Gln Ser Val Val Leu Cys Pro Pro Phe Ile Leu Thr Glu Ala 
            420                 425                 430         
Gln Met Asp Glu Met Phe Asp Lys Leu Glu Lys Ala Leu Asp Lys Val 
        435                 440                 445             
Phe Ala Glu Val Ala                                             
    450                                                         

 
<210> 13
<211> 1359
<212> DNA
<213> Artificial Sequence
 
<220>
<223> variant of transaminase from Vibrio fluvialis Js17
 
<400> 13
atgaacaaac cgcagagctg ggaaacgcgt gcggaaacct atagcctgta tggttttacc 60
gatatgccga gcctgcatca gcgtggcacc gtggtggtga cccatggcga aggcccgtat 120
atcgtggatg tgcatggccg tcgttatctg gatgcgaaca gcggcgctct gaacatggtg 180
gcgggctttg atcataaagg cctgattgat gcggcgaaaa cgcagtatga acgttttccg 240
ggctatcatg cggggagcgg ccgtatgagc gatcagaccg tgatgctgtc tgaaaaactg 300
gtggaagtga gcccgtttga tagcggccgt gtgttttata ccaacagcgg cagcgaagcg 360
aacgatacca tggtgaaaat gctgtggttt ctgcatgcgg cggaaggcaa accgcagaaa 420
cgtaaaattc tgacccgttg gaacgcgtat catggcgcga ccgcggtgag cgcgagcatg 480
accggctttc cgtataacag cgtgtttggc ctgccgctgc cgggctttct gcatctgacc 540
tgcccgcatt attggcgtta tggcgaagaa ggcgaaaccg aagaacagtt tgtcgcgcgt 600
ctggcccgtg aactggaaga aaccattcag aaggaaggcg cggataccat tgcgggcttt 660
tttgcggaac cggtgatggg tgcgggcggt gttattccgc cggcaaaagg ctattttcag 720
gcgattctgc cgatcctgcg caaatatgat attccggtga tcagcgatga agtgatttgc 780
ggcttcggcc gtaccggtaa cacctggggc tgcgtgacct atgattttac cccggatgcg 840
attattagca gtaaaagcct aaccgcgggt ttttttccgg taggcgcggt gattctgggt 900
ccggaactga gcaaacgtct ggaaaccgcg attgaagcga tcgaagaatt tccgcatggt 960
tttaccacag gcggccatcc ggtgggttgt gcgattgcgc tgaaagcgat tgatgtggtg 1020
atgaacgaag gcctggccga aaacgtgcgt cgtctggccc cgcgttttga agaacgtctg 1080
aaacatattg cggaacgtcc gaacattggc gaatatcgtg gcattggctt tatgtgggcg 1140
ctggaagtcg tgaaagataa agcgagcaaa gccccgtttg gtggcaacct gagcgtgagc 1200
gaacgtattg cgaacacctg caccgatctg ggcctgattt gccgtccgct gggccagagc 1260
gtggttctgt gcccgccgtt tattctgacc gaagcgcaga tggatgaaat gttcgataaa 1320
ctggaaaaag cgctggataa agtgttcgcg gaagtggcg                        1359

 
<210> 14
<211> 453
<212> PRT
<213> Artificial Sequence
 
<220>
<223> variant of transaminase from Vibrio fluvialis Js17
 
<400> 14
Met Asn Lys Pro Gln Ser Trp Glu Thr Arg Ala Glu Thr Tyr Ser Leu 
1               5                   10                  15      
Tyr Gly Phe Thr Asp Met Pro Ser Leu His Gln Arg Gly Thr Val Val 
            20                  25                  30          
Val Thr His Gly Glu Gly Pro Tyr Ile Val Asp Val His Gly Arg Arg 
        35                  40                  45              
Tyr Leu Asp Ala Asn Ser Gly Ala Leu Asn Met Val Ala Gly Phe Asp 
    50                  55                  60                  
His Lys Gly Leu Ile Asp Ala Ala Lys Thr Gln Tyr Glu Arg Phe Pro 
65                  70                  75                  80  
Gly Tyr His Ala Gly Ser Gly Arg Met Ser Asp Gln Thr Val Met Leu 
                85                  90                  95      
Ser Glu Lys Leu Val Glu Val Ser Pro Phe Asp Ser Gly Arg Val Phe 
            100                 105                 110         
Tyr Thr Asn Ser Gly Ser Glu Ala Asn Asp Thr Met Val Lys Met Leu 
        115                 120                 125             
Trp Phe Leu His Ala Ala Glu Gly Lys Pro Gln Lys Arg Lys Ile Leu 
    130                 135                 140                 
Thr Arg Trp Asn Ala Tyr His Gly Ala Thr Ala Val Ser Ala Ser Met 
145                 150                 155                 160 
Thr Gly Phe Pro Tyr Asn Ser Val Phe Gly Leu Pro Leu Pro Gly Phe 
                165                 170                 175     
Leu His Leu Thr Cys Pro His Tyr Trp Arg Tyr Gly Glu Glu Gly Glu 
            180                 185                 190         
Thr Glu Glu Gln Phe Val Ala Arg Leu Ala Arg Glu Leu Glu Glu Thr 
        195                 200                 205             
Ile Gln Lys Glu Gly Ala Asp Thr Ile Ala Gly Phe Phe Ala Glu Pro 
    210                 215                 220                 
Val Met Gly Ala Gly Gly Val Ile Pro Pro Ala Lys Gly Tyr Phe Gln 
225                 230                 235                 240 
Ala Ile Leu Pro Ile Leu Arg Lys Tyr Asp Ile Pro Val Ile Ser Asp 
                245                 250                 255     
Glu Val Ile Cys Gly Phe Gly Arg Thr Gly Asn Thr Trp Gly Cys Val 
            260                 265                 270         
Thr Tyr Asp Phe Thr Pro Asp Ala Ile Ile Ser Ser Lys Ser Leu Thr 
        275                 280                 285             
Ala Gly Phe Phe Pro Val Gly Ala Val Ile Leu Gly Pro Glu Leu Ser 
    290                 295                 300                 
Lys Arg Leu Glu Thr Ala Ile Glu Ala Ile Glu Glu Phe Pro His Gly 
305                 310                 315                 320 
Phe Thr Thr Gly Gly His Pro Val Gly Cys Ala Ile Ala Leu Lys Ala 
                325                 330                 335     
Ile Asp Val Val Met Asn Glu Gly Leu Ala Glu Asn Val Arg Arg Leu 
            340                 345                 350         
Ala Pro Arg Phe Glu Glu Arg Leu Lys His Ile Ala Glu Arg Pro Asn 
        355                 360                 365             
Ile Gly Glu Tyr Arg Gly Ile Gly Phe Met Trp Ala Leu Glu Val Val 
    370                 375                 380                 
Lys Asp Lys Ala Ser Lys Ala Pro Phe Gly Gly Asn Leu Ser Val Ser 
385                 390                 395                 400 
Glu Arg Ile Ala Asn Thr Cys Thr Asp Leu Gly Leu Ile Cys Arg Pro 
                405                 410                 415     
Leu Gly Gln Ser Val Val Leu Cys Pro Pro Phe Ile Leu Thr Glu Ala 
            420                 425                 430         
Gln Met Asp Glu Met Phe Asp Lys Leu Glu Lys Ala Leu Asp Lys Val 
        435                 440                 445             
Phe Ala Glu Val Ala                                             
    450                                                         

 
<210> 15
<211> 1359
<212> DNA
<213> Artificial Sequence
 
<220>
<223> variant of transaminase from Vibrio fluvialis Js17
 
<400> 15
atgaacaaac cgcagagctg ggaaacgcgt gcggaaacct atagcctgta tggttttacc 60
gatatgccga gcctgcatca gcgtggcacc gtggtggtga cccatggcga aggcccgtat 120
atcgtggatg tgcatggccg tcgttatctg gatgcgaaca gcggcgctct gaacatggtg 180
gcgggctttg atcataaagg cctgattgat gcggcgaaaa cgcagtatga acgttttccg 240
ggctatcatg cgtctagcgg ccgtatgagc gatcagaccg tgatgctgtc tgaaaaactg 300
gtggaagtga gcccgtttga tagcggccgt gtgttttata ccaacagcgg cagcgaagcg 360
aacgatacca tggtgaaaat gctgtggttt ctgcatgcgg cggaaggcaa accgcagaaa 420
cgtaaaattc tgacccgttg gaacgcgtat catggcgcga ccgcggtgag cgcgagcatg 480
accggctttc cgtataacag cgtgtttggc ctgccgctgc cgggctttct gcatctgacc 540
tgcccgcatt attggcgtta tggcgaagaa ggcgaaaccg aagaacagtt tgtcgcgcgt 600
ctggcccgtg aactggaaga aaccattcag aaggaaggcg cggataccat tgcgggcttt 660
tttgcggaac cggtgatggg tgcgggcggt gttattccgc cggcaaaagg ctattttcag 720
gcgattctgc cgatcctgcg caaatatgat attccggtga tcagcgatga agtgatttgc 780
ggcttcggcc gtaccggtaa cacctggggc tgcgtgacct atgattttac cccggatgcg 840
attattagca gtaaaagcct aaccgcgggt ttttttccgg taggcgcggt gattctgggt 900
ccggaactga gcaaacgtct ggaaaccgcg attgaagcga tcgaagaatt tccgcatggt 960
tttaccacag gcggccatcc ggtgggttgt gcgattgcgc tgaaagcgat tgatgtggtg 1020
atgaacgaag gcctggccga aaacgtgcgt cgtctggccc cgcgttttga agaacgtctg 1080
aaacatattg cggaacgtcc gaacattggc gaatatcgtg gcattggctt tatgtgggcg 1140
ctggaagtcg tgaaagataa agcgagcaaa gccccgtttg gtggcaacct gagcgtgagc 1200
gaacgtattg cgaacacctg caccgatctg ggcctgattt gccgtccgct gggccagagc 1260
gtggttctgt gcccgccgtt tattctgacc gaagcgcaga tggatgaaat gttcgataaa 1320
ctggaaaaag cgctggataa agtgttcgcg gaagtggcg                        1359

 
<210> 16
<211> 453
<212> PRT
<213> Artificial Sequence
 
<220>
<223> variant of transaminase from Vibrio fluvialis Js17
 
<400> 16
Met Asn Lys Pro Gln Ser Trp Glu Thr Arg Ala Glu Thr Tyr Ser Leu 
1               5                   10                  15      
Tyr Gly Phe Thr Asp Met Pro Ser Leu His Gln Arg Gly Thr Val Val 
            20                  25                  30          
Val Thr His Gly Glu Gly Pro Tyr Ile Val Asp Val His Gly Arg Arg 
        35                  40                  45              
Tyr Leu Asp Ala Asn Ser Gly Ala Leu Asn Met Val Ala Gly Phe Asp 
    50                  55                  60                  
His Lys Gly Leu Ile Asp Ala Ala Lys Thr Gln Tyr Glu Arg Phe Pro 
65                  70                  75                  80  
Gly Tyr His Ala Ser Ser Gly Arg Met Ser Asp Gln Thr Val Met Leu 
                85                  90                  95      
Ser Glu Lys Leu Val Glu Val Ser Pro Phe Asp Ser Gly Arg Val Phe 
            100                 105                 110         
Tyr Thr Asn Ser Gly Ser Glu Ala Asn Asp Thr Met Val Lys Met Leu 
        115                 120                 125             
Trp Phe Leu His Ala Ala Glu Gly Lys Pro Gln Lys Arg Lys Ile Leu 
    130                 135                 140                 
Thr Arg Trp Asn Ala Tyr His Gly Ala Thr Ala Val Ser Ala Ser Met 
145                 150                 155                 160 
Thr Gly Phe Pro Tyr Asn Ser Val Phe Gly Leu Pro Leu Pro Gly Phe 
                165                 170                 175     
Leu His Leu Thr Cys Pro His Tyr Trp Arg Tyr Gly Glu Glu Gly Glu 
            180                 185                 190         
Thr Glu Glu Gln Phe Val Ala Arg Leu Ala Arg Glu Leu Glu Glu Thr 
        195                 200                 205             
Ile Gln Lys Glu Gly Ala Asp Thr Ile Ala Gly Phe Phe Ala Glu Pro 
    210                 215                 220                 
Val Met Gly Ala Gly Gly Val Ile Pro Pro Ala Lys Gly Tyr Phe Gln 
225                 230                 235                 240 
Ala Ile Leu Pro Ile Leu Arg Lys Tyr Asp Ile Pro Val Ile Ser Asp 
                245                 250                 255     
Glu Val Ile Cys Gly Phe Gly Arg Thr Gly Asn Thr Trp Gly Cys Val 
            260                 265                 270         
Thr Tyr Asp Phe Thr Pro Asp Ala Ile Ile Ser Ser Lys Ser Leu Thr 
        275                 280                 285             
Ala Gly Phe Phe Pro Val Gly Ala Val Ile Leu Gly Pro Glu Leu Ser 
    290                 295                 300                 
Lys Arg Leu Glu Thr Ala Ile Glu Ala Ile Glu Glu Phe Pro His Gly 
305                 310                 315                 320 
Phe Thr Thr Gly Gly His Pro Val Gly Cys Ala Ile Ala Leu Lys Ala 
                325                 330                 335     
Ile Asp Val Val Met Asn Glu Gly Leu Ala Glu Asn Val Arg Arg Leu 
            340                 345                 350         
Ala Pro Arg Phe Glu Glu Arg Leu Lys His Ile Ala Glu Arg Pro Asn 
        355                 360                 365             
Ile Gly Glu Tyr Arg Gly Ile Gly Phe Met Trp Ala Leu Glu Val Val 
    370                 375                 380                 
Lys Asp Lys Ala Ser Lys Ala Pro Phe Gly Gly Asn Leu Ser Val Ser 
385                 390                 395                 400 
Glu Arg Ile Ala Asn Thr Cys Thr Asp Leu Gly Leu Ile Cys Arg Pro 
                405                 410                 415     
Leu Gly Gln Ser Val Val Leu Cys Pro Pro Phe Ile Leu Thr Glu Ala 
            420                 425                 430         
Gln Met Asp Glu Met Phe Asp Lys Leu Glu Lys Ala Leu Asp Lys Val 
        435                 440                 445             
Phe Ala Glu Val Ala                                             
    450                                                         

 
<210> 17
<211> 1359
<212> DNA
<213> Artificial Sequence
 
<220>
<223> variant of transaminase from Vibrio fluvialis Js17
 
<400> 17
atgaacaaac cgcagagctg ggaaacgcgt gcggaaacct atagcctgta tggttttacc 60
gatatgccga gcctgcatca gcgtggcacc gtggtggtga cccatggcga aggcccgtat 120
atcgtggatg tgcatggccg tcgttatctg gatgcgaaca gcggcgctct gaacatggtg 180
gcgggctttg atcataaagg cctgattgat gcggcgaaaa cgcagtatga acgttttccg 240
ggctatcatg cggttagcgg ccgtatgagc gatcagaccg tgatgctgtc tgaaaaactg 300
gtggaagtga gcccgtttga tagcggccgt gtgttttata ccaacagcgg cagcgaagcg 360
aacgatacca tggtgaaaat gctgtggttt ctgcatgcgg cggaaggcaa accgcagaaa 420
cgtaaaattc tgacccgttg gaacgcgtat catggcgcga ccgcggtgag cgcgagcatg 480
accggctttc cgtataacag cgtgtttggc ctgccgctgc cgggctttct gcatctgacc 540
tgcccgcatt attggcgtta tggcgaagaa ggcgaaaccg aagaacagtt tgtcgcgcgt 600
ctggcccgtg aactggaaga aaccattcag aaggaaggcg cggataccat tgcgggcttt 660
tttgcggaac cggtgatggg tgcgggcggt gttattccgc cggcaaaagg ctattttcag 720
gcgattctgc cgatcctgcg caaatatgat attccggtga tcagcgatga agtgatttgc 780
ggcttcggcc gtaccggtaa cacctggggc tgcgtgacct atgattttac cccggatgcg 840
attattagca gtaaaagcct aaccgcgggt ttttttccgg taggcgcggt gattctgggt 900
ccggaactga gcaaacgtct ggaaaccgcg attgaagcga tcgaagaatt tccgcatggt 960
tttaccacag gcggccatcc ggtgggttgt gcgattgcgc tgaaagcgat tgatgtggtg 1020
atgaacgaag gcctggccga aaacgtgcgt cgtctggccc cgcgttttga agaacgtctg 1080
aaacatattg cggaacgtcc gaacattggc gaatatcgtg gcattggctt tatgtgggcg 1140
ctggaagtcg tgaaagataa agcgagcaaa gccccgtttg gtggcaacct gagcgtgagc 1200
gaacgtattg cgaacacctg caccgatctg ggcctgattt gccgtccgct gggccagagc 1260
gtggttctgt gcccgccgtt tattctgacc gaagcgcaga tggatgaaat gttcgataaa 1320
ctggaaaaag cgctggataa agtgttcgcg gaagtggcg                        1359

 
<210> 18
<211> 453
<212> PRT
<213> Artificial Sequence
 
<220>
<223> variant of transaminase from Vibrio fluvialis Js17
 
<400> 18
Met Asn Lys Pro Gln Ser Trp Glu Thr Arg Ala Glu Thr Tyr Ser Leu 
1               5                   10                  15      
Tyr Gly Phe Thr Asp Met Pro Ser Leu His Gln Arg Gly Thr Val Val 
            20                  25                  30          
Val Thr His Gly Glu Gly Pro Tyr Ile Val Asp Val His Gly Arg Arg 
        35                  40                  45              
Tyr Leu Asp Ala Asn Ser Gly Ala Leu Asn Met Val Ala Gly Phe Asp 
    50                  55                  60                  
His Lys Gly Leu Ile Asp Ala Ala Lys Thr Gln Tyr Glu Arg Phe Pro 
65                  70                  75                  80  
Gly Tyr His Ala Val Ser Gly Arg Met Ser Asp Gln Thr Val Met Leu 
                85                  90                  95      
Ser Glu Lys Leu Val Glu Val Ser Pro Phe Asp Ser Gly Arg Val Phe 
            100                 105                 110         
Tyr Thr Asn Ser Gly Ser Glu Ala Asn Asp Thr Met Val Lys Met Leu 
        115                 120                 125             
Trp Phe Leu His Ala Ala Glu Gly Lys Pro Gln Lys Arg Lys Ile Leu 
    130                 135                 140                 
Thr Arg Trp Asn Ala Tyr His Gly Ala Thr Ala Val Ser Ala Ser Met 
145                 150                 155                 160 
Thr Gly Phe Pro Tyr Asn Ser Val Phe Gly Leu Pro Leu Pro Gly Phe 
                165                 170                 175     
Leu His Leu Thr Cys Pro His Tyr Trp Arg Tyr Gly Glu Glu Gly Glu 
            180                 185                 190         
Thr Glu Glu Gln Phe Val Ala Arg Leu Ala Arg Glu Leu Glu Glu Thr 
        195                 200                 205             
Ile Gln Lys Glu Gly Ala Asp Thr Ile Ala Gly Phe Phe Ala Glu Pro 
    210                 215                 220                 
Val Met Gly Ala Gly Gly Val Ile Pro Pro Ala Lys Gly Tyr Phe Gln 
225                 230                 235                 240 
Ala Ile Leu Pro Ile Leu Arg Lys Tyr Asp Ile Pro Val Ile Ser Asp 
                245                 250                 255     
Glu Val Ile Cys Gly Phe Gly Arg Thr Gly Asn Thr Trp Gly Cys Val 
            260                 265                 270         
Thr Tyr Asp Phe Thr Pro Asp Ala Ile Ile Ser Ser Lys Ser Leu Thr 
        275                 280                 285             
Ala Gly Phe Phe Pro Val Gly Ala Val Ile Leu Gly Pro Glu Leu Ser 
    290                 295                 300                 
Lys Arg Leu Glu Thr Ala Ile Glu Ala Ile Glu Glu Phe Pro His Gly 
305                 310                 315                 320 
Phe Thr Thr Gly Gly His Pro Val Gly Cys Ala Ile Ala Leu Lys Ala 
                325                 330                 335     
Ile Asp Val Val Met Asn Glu Gly Leu Ala Glu Asn Val Arg Arg Leu 
            340                 345                 350         
Ala Pro Arg Phe Glu Glu Arg Leu Lys His Ile Ala Glu Arg Pro Asn 
        355                 360                 365             
Ile Gly Glu Tyr Arg Gly Ile Gly Phe Met Trp Ala Leu Glu Val Val 
    370                 375                 380                 
Lys Asp Lys Ala Ser Lys Ala Pro Phe Gly Gly Asn Leu Ser Val Ser 
385                 390                 395                 400 
Glu Arg Ile Ala Asn Thr Cys Thr Asp Leu Gly Leu Ile Cys Arg Pro 
                405                 410                 415     
Leu Gly Gln Ser Val Val Leu Cys Pro Pro Phe Ile Leu Thr Glu Ala 
            420                 425                 430         
Gln Met Asp Glu Met Phe Asp Lys Leu Glu Lys Ala Leu Asp Lys Val 
        435                 440                 445             
Phe Ala Glu Val Ala                                             
    450                                                         

 
<210> 19
<211> 1359
<212> DNA
<213> Artificial Sequence
 
<220>
<223> variant of transaminase from Vibrio fluvialis Js17
 
<400> 19
atgaacaaac cgcagagctg ggaaacgcgt gcggaaacct atagcctgta tggttttacc 60
gatatgccga gcctgcatca gcgtggcacc gtggtggtga cccatggcga aggcccgtat 120
atcgtggatg tgcatggccg tcgttatctg gatgcgaaca gcggcgctct gaacatggtg 180
gcgggctttg atcataaagg cctgattgat gcggcgaaaa cgcagtatga acgttttccg 240
ggctatcatg cggttgcggg ccgtatgagc gatcagaccg tgatgctgtc tgaaaaactg 300
gtggaagtga gcccgtttga tagcggccgt gtgttttata ccaacagcgg cagcgaagcg 360
aacgatacca tggtgaaaat gctgtggttt ctgcatgcgg cggaaggcaa accgcagaaa 420
cgtaaaattc tgacccgttg gaacgcgtat catggcgcga ccgcggtgag cgcgagcatg 480
accggctttc cgtataacag cgtgtttggc ctgccgctgc cgggctttct gcatctgacc 540
tgcccgcatt attggcgtta tggcgaagaa ggcgaaaccg aagaacagtt tgtcgcgcgt 600
ctggcccatg aactggaaga aaccattcag aaggaaggcg cggataccat tgcgggcttt 660
tttgcggaac cggtgatggg tgcgggcggt gttattccgc cggcaaaagg ctattttcag 720
gcgattctgc cgatcctgcg caaatatgat attccggtga tcagcgatga agtgatttgc 780
ggcttcggcc gtaccggtaa cacctggggc tgcgtgacct atgattttac cccggatgcg 840
attattagca gtaaaagcct aaccgcgggt ttttttccgg taggcgcggt gattctgggt 900
ccggaactga gcaaacgtct ggaaaccgcg attgaagcga tcgaaatgtt tccgcatggt 960
tttaccacag gcggccatcc ggtgggttgt gcgattgcgc tgaaagcgat tgatgtggtg 1020
atgaacgaag gcctggccga aaacgtgcgt cgtctggccc cgcgttttga agaacgtctg 1080
aaacatattg cggaacgtcc gaacattggc gaatatcgtg gcattggctt tatgtgggcg 1140
ctggaagtcg tgaaagataa agcgagcaaa gccccgtttg gtggcaacct gagcgtgagc 1200
gaacgtattg cgaacacctg caccgatctg ggcctgattt gccgtggcct gggccagagc 1260
gtggttctgt gcccgccgtt tattctgacc gaagcgcaga tggatgaaat gttcgataaa 1320
ctggaaaaag cgctggataa agtgttcgcg gaagtggcg                        1359

 
<210> 20
<211> 453
<212> PRT
<213> Artificial Sequence
 
<220>
<223> variant of transaminase from Vibrio fluvialis Js17
 
<400> 20
Met Asn Lys Pro Gln Ser Trp Glu Thr Arg Ala Glu Thr Tyr Ser Leu 
1               5                   10                  15      
Tyr Gly Phe Thr Asp Met Pro Ser Leu His Gln Arg Gly Thr Val Val 
            20                  25                  30          
Val Thr His Gly Glu Gly Pro Tyr Ile Val Asp Val His Gly Arg Arg 
        35                  40                  45              
Tyr Leu Asp Ala Asn Ser Gly Ala Leu Asn Met Val Ala Gly Phe Asp 
    50                  55                  60                  
His Lys Gly Leu Ile Asp Ala Ala Lys Thr Gln Tyr Glu Arg Phe Pro 
65                  70                  75                  80  
Gly Tyr His Ala Val Ala Gly Arg Met Ser Asp Gln Thr Val Met Leu 
                85                  90                  95      
Ser Glu Lys Leu Val Glu Val Ser Pro Phe Asp Ser Gly Arg Val Phe 
            100                 105                 110         
Tyr Thr Asn Ser Gly Ser Glu Ala Asn Asp Thr Met Val Lys Met Leu 
        115                 120                 125             
Trp Phe Leu His Ala Ala Glu Gly Lys Pro Gln Lys Arg Lys Ile Leu 
    130                 135                 140                 
Thr Arg Trp Asn Ala Tyr His Gly Ala Thr Ala Val Ser Ala Ser Met 
145                 150                 155                 160 
Thr Gly Phe Pro Tyr Asn Ser Val Phe Gly Leu Pro Leu Pro Gly Phe 
                165                 170                 175     
Leu His Leu Thr Cys Pro His Tyr Trp Arg Tyr Gly Glu Glu Gly Glu 
            180                 185                 190         
Thr Glu Glu Gln Phe Val Ala Arg Leu Ala His Glu Leu Glu Glu Thr 
        195                 200                 205             
Ile Gln Lys Glu Gly Ala Asp Thr Ile Ala Gly Phe Phe Ala Glu Pro 
    210                 215                 220                 
Val Met Gly Ala Gly Gly Val Ile Pro Pro Ala Lys Gly Tyr Phe Gln 
225                 230                 235                 240 
Ala Ile Leu Pro Ile Leu Arg Lys Tyr Asp Ile Pro Val Ile Ser Asp 
                245                 250                 255     
Glu Val Ile Cys Gly Phe Gly Arg Thr Gly Asn Thr Trp Gly Cys Val 
            260                 265                 270         
Thr Tyr Asp Phe Thr Pro Asp Ala Ile Ile Ser Ser Lys Ser Leu Thr 
        275                 280                 285             
Ala Gly Phe Phe Pro Val Gly Ala Val Ile Leu Gly Pro Glu Leu Ser 
    290                 295                 300                 
Lys Arg Leu Glu Thr Ala Ile Glu Ala Ile Glu Met Phe Pro His Gly 
305                 310                 315                 320 
Phe Thr Thr Gly Gly His Pro Val Gly Cys Ala Ile Ala Leu Lys Ala 
                325                 330                 335     
Ile Asp Val Val Met Asn Glu Gly Leu Ala Glu Asn Val Arg Arg Leu 
            340                 345                 350         
Ala Pro Arg Phe Glu Glu Arg Leu Lys His Ile Ala Glu Arg Pro Asn 
        355                 360                 365             
Ile Gly Glu Tyr Arg Gly Ile Gly Phe Met Trp Ala Leu Glu Val Val 
    370                 375                 380                 
Lys Asp Lys Ala Ser Lys Ala Pro Phe Gly Gly Asn Leu Ser Val Ser 
385                 390                 395                 400 
Glu Arg Ile Ala Asn Thr Cys Thr Asp Leu Gly Leu Ile Cys Arg Gly 
                405                 410                 415     
Leu Gly Gln Ser Val Val Leu Cys Pro Pro Phe Ile Leu Thr Glu Ala 
            420                 425                 430         
Gln Met Asp Glu Met Phe Asp Lys Leu Glu Lys Ala Leu Asp Lys Val 
        435                 440                 445             
Phe Ala Glu Val Ala                                             
    450                                                         

 
<210> 21
<211> 1359
<212> DNA
<213> Artificial Sequence
 
<220>
<223> variant of transaminase from Vibrio fluvialis Js17
 
<400> 21
atgaacaaac cgcagagctg ggaaacgcgt gcggaaacct atagcctgta tggttttacc 60
gatatgccga gcctgcatca gcgtggcacc gtggtggtga cccatggcga aggcccgtat 120
atcgtggatg tgcatggccg tcgttatctg gatgcgaaca gcggcgctct gaacatggtg 180
gcgggctttg atcataaagg cctgattgat gcggcgaaaa cgcagtatga acgttttccg 240
ggctatcatg cggttgcggg ccgtatgagc gatcagaccg tgatgctgtc tgaaaaactg 300
gtggaagtga gcccgtttga tagcggccgt gtgttttata ccaacagcgg cagcgaagcg 360
aacgatacca tggtgaaaat gctgtggttt ctgcatgcgg cggaaggcaa accgcagaaa 420
cgtaaaattc tgacccgttg gaacgcgtat catggcgcga ccgcggtgag cgcgagcatg 480
accggctttc cgtataacag cgtgtttggc ctgccgctgc cgggctttct gcatctgacc 540
tgcccgcatt attggcgtta tggcgaagaa ggcgaaaccg aagaacagtt tgtcgcgcgt 600
ctggcccgtg aactggaaga aaccattcag aaggaaggcg cggataccat tgcgggcttt 660
tttgcggaac cggtgatggg tgcgggcggt gttattccgc cggcaaaagg ctattttcag 720
gcgattctgc cgatcctgcg caaatatgat attccggtga tcagcgatga agtgatttgc 780
ggcttcggcc gtaccggtaa cacctggggc tgcgtgacct atgattttac cccggatgcg 840
attattagca gtaaaagcct aaccgcgggt ttttttccgg taggcgcggt gattctgggt 900
ccggaactga gcaaacgtct ggaaaccgcg attgaagcga tcgaaagctt tccgcatggt 960
tttaccacag gcggccatcc ggtgggttgt gcgattgcgc tgaaagcgat tgatgtggtg 1020
atgaacgaag gcctggccga aaacgtgcgt cgtctggccc cgcgttttga agaacgtctg 1080
aaacatattg cggaacgtcc gaacattggc gaatatcgtg gcattggctt tatgtgggcg 1140
ctggaagtcg tgaaagataa agcgagcaaa gccccgtttg gtggcaacct gagcgtgagc 1200
gaacgtattg cgaacacctg caccgatctg ggcctgattt gccgttgcct gggccagagc 1260
gtggttctgt gcccgccgtt tattctgacc gaagcgcaga tggatgaaat gttcgataaa 1320
ctggaaaaag cgctggataa agtgttcgcg gaagtggcg                        1359

 
<210> 22
<211> 453
<212> PRT
<213> Artificial Sequence
 
<220>
<223> variant of transaminase from Vibrio fluvialis Js17
 
<400> 22
Met Asn Lys Pro Gln Ser Trp Glu Thr Arg Ala Glu Thr Tyr Ser Leu 
1               5                   10                  15      
Tyr Gly Phe Thr Asp Met Pro Ser Leu His Gln Arg Gly Thr Val Val 
            20                  25                  30          
Val Thr His Gly Glu Gly Pro Tyr Ile Val Asp Val His Gly Arg Arg 
        35                  40                  45              
Tyr Leu Asp Ala Asn Ser Gly Ala Leu Asn Met Val Ala Gly Phe Asp 
    50                  55                  60                  
His Lys Gly Leu Ile Asp Ala Ala Lys Thr Gln Tyr Glu Arg Phe Pro 
65                  70                  75                  80  
Gly Tyr His Ala Val Ala Gly Arg Met Ser Asp Gln Thr Val Met Leu 
                85                  90                  95      
Ser Glu Lys Leu Val Glu Val Ser Pro Phe Asp Ser Gly Arg Val Phe 
            100                 105                 110         
Tyr Thr Asn Ser Gly Ser Glu Ala Asn Asp Thr Met Val Lys Met Leu 
        115                 120                 125             
Trp Phe Leu His Ala Ala Glu Gly Lys Pro Gln Lys Arg Lys Ile Leu 
    130                 135                 140                 
Thr Arg Trp Asn Ala Tyr His Gly Ala Thr Ala Val Ser Ala Ser Met 
145                 150                 155                 160 
Thr Gly Phe Pro Tyr Asn Ser Val Phe Gly Leu Pro Leu Pro Gly Phe 
                165                 170                 175     
Leu His Leu Thr Cys Pro His Tyr Trp Arg Tyr Gly Glu Glu Gly Glu 
            180                 185                 190         
Thr Glu Glu Gln Phe Val Ala Arg Leu Ala Arg Glu Leu Glu Glu Thr 
        195                 200                 205             
Ile Gln Lys Glu Gly Ala Asp Thr Ile Ala Gly Phe Phe Ala Glu Pro 
    210                 215                 220                 
Val Met Gly Ala Gly Gly Val Ile Pro Pro Ala Lys Gly Tyr Phe Gln 
225                 230                 235                 240 
Ala Ile Leu Pro Ile Leu Arg Lys Tyr Asp Ile Pro Val Ile Ser Asp 
                245                 250                 255     
Glu Val Ile Cys Gly Phe Gly Arg Thr Gly Asn Thr Trp Gly Cys Val 
            260                 265                 270         
Thr Tyr Asp Phe Thr Pro Asp Ala Ile Ile Ser Ser Lys Ser Leu Thr 
        275                 280                 285             
Ala Gly Phe Phe Pro Val Gly Ala Val Ile Leu Gly Pro Glu Leu Ser 
    290                 295                 300                 
Lys Arg Leu Glu Thr Ala Ile Glu Ala Ile Glu Ser Phe Pro His Gly 
305                 310                 315                 320 
Phe Thr Thr Gly Gly His Pro Val Gly Cys Ala Ile Ala Leu Lys Ala 
                325                 330                 335     
Ile Asp Val Val Met Asn Glu Gly Leu Ala Glu Asn Val Arg Arg Leu 
            340                 345                 350         
Ala Pro Arg Phe Glu Glu Arg Leu Lys His Ile Ala Glu Arg Pro Asn 
        355                 360                 365             
Ile Gly Glu Tyr Arg Gly Ile Gly Phe Met Trp Ala Leu Glu Val Val 
    370                 375                 380                 
Lys Asp Lys Ala Ser Lys Ala Pro Phe Gly Gly Asn Leu Ser Val Ser 
385                 390                 395                 400 
Glu Arg Ile Ala Asn Thr Cys Thr Asp Leu Gly Leu Ile Cys Arg Cys 
                405                 410                 415     
Leu Gly Gln Ser Val Val Leu Cys Pro Pro Phe Ile Leu Thr Glu Ala 
            420                 425                 430         
Gln Met Asp Glu Met Phe Asp Lys Leu Glu Lys Ala Leu Asp Lys Val 
        435                 440                 445             
Phe Ala Glu Val Ala                                             
    450                                                         

 
<210> 23
<211> 1359
<212> DNA
<213> Artificial Sequence
 
<220>
<223> variant of transaminase from Vibrio fluvialis Js17
 
<400> 23
atgaacaaac cgcagagctg ggaaacgcgt gcggaaacct atagcctgta tggttttacc 60
gatatgccga gcctgcatca gcgtggcacc gtggtggtga cccatggcga aggcccgtat 120
atcgtggatg tgcatggccg tcgttatctg gatgcgaaca gcggcgctct gaacatggtg 180
gcgggctttg atcataaagg cctgattgat gcggcgaaaa cgcagtatga acgttttccg 240
ggctatcatg cggttgcggg ccgtatgagc gatcagaccg tgatgctgtc tgaaaaactg 300
gtggaagtga gcccgtttga tagcggccgt gtgttttata ccaacagcgg cagcgaagcg 360
aacgatacca tggtgaaaat gctgtggttt ctgcatgcgg cggaaggcaa accgcagaaa 420
cgtaaaattc tgacccgttg gaacgcgtat catggcgcga ccgcggtgag cgcgagcatg 480
accggctttc cgtataacag cgtgtttggc ctgccgctgc cgggctttct gcatctgacc 540
tgcccgcatt attggcgtta tggcgaagaa ggcgaaaccg aagaacagtt tgtcgcgcgt 600
ctggcccatg aactggaaga aaccattcag aaggaaggcg cggataccat tgcgggcttt 660
tttgcggaac cggtgatggg tgcgggcggt gttattccgc cggcaaaagg ctattttcag 720
gcgattctgc cgatcctgcg caaatatgat attccggtga tcagcgatga agtgatttgc 780
ggcttcggcc gtaccggtaa cacctggggc tgcgtgacct atgattttac cccggatgcg 840
attattagca gtaaaagcct aaccgcgggt ttttttccgg taggcgcggt gattctgggt 900
ccggaactga gcaaacgtct ggaaaccgcg attgaagcga tcgaaatgtt tccgcatggt 960
tttaccacag gcggccatcc ggtgggttgt gcgattgcgc tgaaagcgat tgatgtggtg 1020
atgaacgaag gcctggccga aaacgtgcgt cgtctggccc cgcgttttga agaacgtctg 1080
aaacatattg cggaacgtcc gaacattggc gaatatcgtg gcattggctt tatgtgggcg 1140
ctggaagtcg tgaaagataa agcgagcaaa gccccgtttg gtggcaacct gagcgtgagc 1200
gaacgtattg cgaacacctg caccgatctg ggcctgattt gccgtccgct gggccagagc 1260
gtgggcctgt gcccgccgtt tattctgacc gaagcgcaga tggatgaaat gttcgataaa 1320
ctggaaaaag cgctggataa agtgttcgcg gaagtggcg                        1359

 
<210> 24
<211> 453
<212> PRT
<213> Artificial Sequence
 
<220>
<223> variant of transaminase from Vibrio fluvialis Js17
 
<400> 24
Met Asn Lys Pro Gln Ser Trp Glu Thr Arg Ala Glu Thr Tyr Ser Leu 
1               5                   10                  15      
Tyr Gly Phe Thr Asp Met Pro Ser Leu His Gln Arg Gly Thr Val Val 
            20                  25                  30          
Val Thr His Gly Glu Gly Pro Tyr Ile Val Asp Val His Gly Arg Arg 
        35                  40                  45              
Tyr Leu Asp Ala Asn Ser Gly Ala Leu Asn Met Val Ala Gly Phe Asp 
    50                  55                  60                  
His Lys Gly Leu Ile Asp Ala Ala Lys Thr Gln Tyr Glu Arg Phe Pro 
65                  70                  75                  80  
Gly Tyr His Ala Val Ala Gly Arg Met Ser Asp Gln Thr Val Met Leu 
                85                  90                  95      
Ser Glu Lys Leu Val Glu Val Ser Pro Phe Asp Ser Gly Arg Val Phe 
            100                 105                 110         
Tyr Thr Asn Ser Gly Ser Glu Ala Asn Asp Thr Met Val Lys Met Leu 
        115                 120                 125             
Trp Phe Leu His Ala Ala Glu Gly Lys Pro Gln Lys Arg Lys Ile Leu 
    130                 135                 140                 
Thr Arg Trp Asn Ala Tyr His Gly Ala Thr Ala Val Ser Ala Ser Met 
145                 150                 155                 160 
Thr Gly Phe Pro Tyr Asn Ser Val Phe Gly Leu Pro Leu Pro Gly Phe 
                165                 170                 175     
Leu His Leu Thr Cys Pro His Tyr Trp Arg Tyr Gly Glu Glu Gly Glu 
            180                 185                 190         
Thr Glu Glu Gln Phe Val Ala Arg Leu Ala His Glu Leu Glu Glu Thr 
        195                 200                 205             
Ile Gln Lys Glu Gly Ala Asp Thr Ile Ala Gly Phe Phe Ala Glu Pro 
    210                 215                 220                 
Val Met Gly Ala Gly Gly Val Ile Pro Pro Ala Lys Gly Tyr Phe Gln 
225                 230                 235                 240 
Ala Ile Leu Pro Ile Leu Arg Lys Tyr Asp Ile Pro Val Ile Ser Asp 
                245                 250                 255     
Glu Val Ile Cys Gly Phe Gly Arg Thr Gly Asn Thr Trp Gly Cys Val 
            260                 265                 270         
Thr Tyr Asp Phe Thr Pro Asp Ala Ile Ile Ser Ser Lys Ser Leu Thr 
        275                 280                 285             
Ala Gly Phe Phe Pro Val Gly Ala Val Ile Leu Gly Pro Glu Leu Ser 
    290                 295                 300                 
Lys Arg Leu Glu Thr Ala Ile Glu Ala Ile Glu Met Phe Pro His Gly 
305                 310                 315                 320 
Phe Thr Thr Gly Gly His Pro Val Gly Cys Ala Ile Ala Leu Lys Ala 
                325                 330                 335     
Ile Asp Val Val Met Asn Glu Gly Leu Ala Glu Asn Val Arg Arg Leu 
            340                 345                 350         
Ala Pro Arg Phe Glu Glu Arg Leu Lys His Ile Ala Glu Arg Pro Asn 
        355                 360                 365             
Ile Gly Glu Tyr Arg Gly Ile Gly Phe Met Trp Ala Leu Glu Val Val 
    370                 375                 380                 
Lys Asp Lys Ala Ser Lys Ala Pro Phe Gly Gly Asn Leu Ser Val Ser 
385                 390                 395                 400 
Glu Arg Ile Ala Asn Thr Cys Thr Asp Leu Gly Leu Ile Cys Arg Pro 
                405                 410                 415     
Leu Gly Gln Ser Val Gly Leu Cys Pro Pro Phe Ile Leu Thr Glu Ala 
            420                 425                 430         
Gln Met Asp Glu Met Phe Asp Lys Leu Glu Lys Ala Leu Asp Lys Val 
        435                 440                 445             
Phe Ala Glu Val Ala                                             
    450                                                         

 
<210> 25
<211> 1359
<212> DNA
<213> Artificial Sequence
 
<220>
<223> variant of transaminase from Vibrio fluvialis Js17
 
<400> 25
atgaacaaac cgcagagctg ggaaacgcgt gcggaaacct atagcctgta tggttttacc 60
gatatgccga gcctgcatca gcgtggcacc gtggtggtga cccatggcga aggcccgtat 120
atcgtggatg tgcatggccg tcgttatctg gatgcgaaca gcggcgctct gaacatggtg 180
gcgggctttg atcataaagg cctgattgat gcggcgaaaa cgcagtatga acgttttccg 240
ggctatcatg cggttagcgg ccgtatgagc gatcagaccg tgatgctgtc tgaaaaactg 300
gtggaagtga gcccgtttga tagcggccgt gtgttttata ccaacagcgg cagcgaagcg 360
aacgatacca tggtgaaaat gctgtggttt ctgcatgcgg cggaaggcaa accgcagaaa 420
cgtaaaattc tgacccgttg gaacgcgtat catggcgcga ccgcggtgag cgcgagcatg 480
accggctttc cgtataacag cgtgtttggc ctgccgctgc cgggctttct gcatctgacc 540
tgcccgcatt attggcgtta tggcgaagaa ggcgaaaccg aagaacagtt tgtcgcgcgt 600
ctggcccgtg aactggaaga aaccattcag aaggaaggcg cggataccat tgcgggcttt 660
tttgcggaac cggtgatggg tgcgggcggt gttattccgc cggcaaaagg ctattttcag 720
gcgattctgc cgatcctgcg caaatatgat attccggtga tcagcgatga agtgatttgc 780
ggcttcggcc gtaccggtaa cacctggggc tgcgtgacct atgattttac cccggatgcg 840
attattagca gtaaaagcct aaccgcgggt ttttttccgg taggcgcggt gattctgggt 900
ccggaactga gcaaacgtct ggaaaccgcg attgaagcga tcgaagaatt tccgcatggt 960
tttaccacag gcggccatcc ggtgggttgt gcgattgcgc tgaaagcgat tgatgtggtg 1020
atgaacgaag gcctggccga aaacgtgcgt cgtctggccc cgcgttttga agaacgtctg 1080
aaacatattg cggaacgtcc gaacattggc gaatatcgtg gcattggctt tatgtgggcg 1140
ctggaagtcg tgaaagataa agcgagcaaa gccccgtttg gtggcaacct gagcgtgagc 1200
gaacgtattg cgaacacctg caccgatctg ggcctgattt gccgtccgct gggccagagc 1260
gtgtgtctgt gcccgccgtt tattctgacc gaagcgcaga tggatgaaat gttcgataaa 1320
ctggaaaaag cgctggataa agtgttcgcg gaagtggcg                        1359

 
<210> 26
<211> 453
<212> PRT
<213> Artificial Sequence
 
<220>
<223> variant of transaminase from Vibrio fluvialis Js17
 
<400> 26
Met Asn Lys Pro Gln Ser Trp Glu Thr Arg Ala Glu Thr Tyr Ser Leu 
1               5                   10                  15      
Tyr Gly Phe Thr Asp Met Pro Ser Leu His Gln Arg Gly Thr Val Val 
            20                  25                  30          
Val Thr His Gly Glu Gly Pro Tyr Ile Val Asp Val His Gly Arg Arg 
        35                  40                  45              
Tyr Leu Asp Ala Asn Ser Gly Ala Leu Asn Met Val Ala Gly Phe Asp 
    50                  55                  60                  
His Lys Gly Leu Ile Asp Ala Ala Lys Thr Gln Tyr Glu Arg Phe Pro 
65                  70                  75                  80  
Gly Tyr His Ala Val Ser Gly Arg Met Ser Asp Gln Thr Val Met Leu 
                85                  90                  95      
Ser Glu Lys Leu Val Glu Val Ser Pro Phe Asp Ser Gly Arg Val Phe 
            100                 105                 110         
Tyr Thr Asn Ser Gly Ser Glu Ala Asn Asp Thr Met Val Lys Met Leu 
        115                 120                 125             
Trp Phe Leu His Ala Ala Glu Gly Lys Pro Gln Lys Arg Lys Ile Leu 
    130                 135                 140                 
Thr Arg Trp Asn Ala Tyr His Gly Ala Thr Ala Val Ser Ala Ser Met 
145                 150                 155                 160 
Thr Gly Phe Pro Tyr Asn Ser Val Phe Gly Leu Pro Leu Pro Gly Phe 
                165                 170                 175     
Leu His Leu Thr Cys Pro His Tyr Trp Arg Tyr Gly Glu Glu Gly Glu 
            180                 185                 190         
Thr Glu Glu Gln Phe Val Ala Arg Leu Ala Arg Glu Leu Glu Glu Thr 
        195                 200                 205             
Ile Gln Lys Glu Gly Ala Asp Thr Ile Ala Gly Phe Phe Ala Glu Pro 
    210                 215                 220                 
Val Met Gly Ala Gly Gly Val Ile Pro Pro Ala Lys Gly Tyr Phe Gln 
225                 230                 235                 240 
Ala Ile Leu Pro Ile Leu Arg Lys Tyr Asp Ile Pro Val Ile Ser Asp 
                245                 250                 255     
Glu Val Ile Cys Gly Phe Gly Arg Thr Gly Asn Thr Trp Gly Cys Val 
            260                 265                 270         
Thr Tyr Asp Phe Thr Pro Asp Ala Ile Ile Ser Ser Lys Ser Leu Thr 
        275                 280                 285             
Ala Gly Phe Phe Pro Val Gly Ala Val Ile Leu Gly Pro Glu Leu Ser 
    290                 295                 300                 
Lys Arg Leu Glu Thr Ala Ile Glu Ala Ile Glu Glu Phe Pro His Gly 
305                 310                 315                 320 
Phe Thr Thr Gly Gly His Pro Val Gly Cys Ala Ile Ala Leu Lys Ala 
                325                 330                 335     
Ile Asp Val Val Met Asn Glu Gly Leu Ala Glu Asn Val Arg Arg Leu 
            340                 345                 350         
Ala Pro Arg Phe Glu Glu Arg Leu Lys His Ile Ala Glu Arg Pro Asn 
        355                 360                 365             
Ile Gly Glu Tyr Arg Gly Ile Gly Phe Met Trp Ala Leu Glu Val Val 
    370                 375                 380                 
Lys Asp Lys Ala Ser Lys Ala Pro Phe Gly Gly Asn Leu Ser Val Ser 
385                 390                 395                 400 
Glu Arg Ile Ala Asn Thr Cys Thr Asp Leu Gly Leu Ile Cys Arg Pro 
                405                 410                 415     
Leu Gly Gln Ser Val Cys Leu Cys Pro Pro Phe Ile Leu Thr Glu Ala 
            420                 425                 430         
Gln Met Asp Glu Met Phe Asp Lys Leu Glu Lys Ala Leu Asp Lys Val 
        435                 440                 445             
Phe Ala Glu Val Ala                                             
    450                                                         

 
<210> 27
<211> 1359
<212> DNA
<213> Artificial Sequence
 
<220>
<223> variant of transaminase from Vibrio fluvialis Js17
 
<400> 27
atgaacaaac cgcagagctg ggaaacgcgt gcggaaacct atagcctggt gggttttacc 60
gatatgccga gcctgcatca gcgtggcacc gtggtggtga cccatggcga aggcccgtat 120
atcgtggatg tgcatggccg tcgttatctg gatgcgaaca gcggcgctct gaacatggtg 180
gcgggctttg atcataaagg cctgattgat gcggcgaaaa cgcagtatga acgttttccg 240
ggctatcatg cggttgcggg ccgtatgagc gatcagaccg tgatgctgtc tgaaaaactg 300
gtggaagtga gcccgtttga tagcggccgt gtgttttata ccaacagcgg cagcgaagcg 360
aacgatacca tggtgaaaat gctgtggttt ctgcatgcgg cggaaggcaa accgcagaaa 420
cgtaaaattc tgacccgttg gaacgcgtat catggcgcga ccgcggtgag cgcgagcatg 480
accggctttc cgtataacag cgtgtttggc ctgccgctgc cgggctttct gcatctgacc 540
tgcccgcatt attggcgtta tggcgaagaa ggcgaaaccg aagaacagtt tgtcgcgcgt 600
ctggcccatg aactggaaga aaccattcag aaggaaggcg cggataccat tgcgggcttt 660
tttgcggaac cggtgatggg tgcgggcggt gttattccgc cggcaaaagg ctattttcag 720
gcgattctgc cgatcctgcg caaatatgat attccggtga tcagcgatga agtgatttgc 780
ggcttcggcc gtaccggtaa cacctggggc tgcgtgacct atgattttac cccggatgcg 840
attattagca gtaaaagcct aaccgcgggt ttttttccgg taggcgcggt gattctgggt 900
ccggaactga gcaaacgtct ggaaaccgcg attgaagcgc gtgaatggtt tccgcatggt 960
tttaccacag gcggccatcc ggtgggttgt gcgattgcgc tgaaagcgat tgatgtggtg 1020
atgaacgaag gcctggccga aaacgtgcgt cgtctggccc cgcgttttga agaacgtctg 1080
aaacatattg cggaacgtcc gaacattggc gaatatcgtg gcattggctt tatgtgggcg 1140
ctggaagtcg tgaaagataa agcgagcaaa gccccgtttg gtggcaacct gagcgtgagc 1200
gaacgtattg cgaacacctg caccgatctg ggcctgattg tgcgtagcat gggccagagc 1260
gtggcgctgt gcccgccgtt tattctgacc gaagcgcaga tggatgaaat gttcgataaa 1320
ctggaaaaag cgctggataa agtgttcgcg gaagtggcg                        1359

 
<210> 28
<211> 453
<212> PRT
<213> Artificial Sequence
 
<220>
<223> variant of transaminase from Vibrio fluvialis Js17
 
<400> 28
Met Asn Lys Pro Gln Ser Trp Glu Thr Arg Ala Glu Thr Tyr Ser Leu 
1               5                   10                  15      
Val Gly Phe Thr Asp Met Pro Ser Leu His Gln Arg Gly Thr Val Val 
            20                  25                  30          
Val Thr His Gly Glu Gly Pro Tyr Ile Val Asp Val His Gly Arg Arg 
        35                  40                  45              
Tyr Leu Asp Ala Asn Ser Gly Ala Leu Asn Met Val Ala Gly Phe Asp 
    50                  55                  60                  
His Lys Gly Leu Ile Asp Ala Ala Lys Thr Gln Tyr Glu Arg Phe Pro 
65                  70                  75                  80  
Gly Tyr His Ala Val Ala Gly Arg Met Ser Asp Gln Thr Val Met Leu 
                85                  90                  95      
Ser Glu Lys Leu Val Glu Val Ser Pro Phe Asp Ser Gly Arg Val Phe 
            100                 105                 110         
Tyr Thr Asn Ser Gly Ser Glu Ala Asn Asp Thr Met Val Lys Met Leu 
        115                 120                 125             
Trp Phe Leu His Ala Ala Glu Gly Lys Pro Gln Lys Arg Lys Ile Leu 
    130                 135                 140                 
Thr Arg Trp Asn Ala Tyr His Gly Ala Thr Ala Val Ser Ala Ser Met 
145                 150                 155                 160 
Thr Gly Phe Pro Tyr Asn Ser Val Phe Gly Leu Pro Leu Pro Gly Phe 
                165                 170                 175     
Leu His Leu Thr Cys Pro His Tyr Trp Arg Tyr Gly Glu Glu Gly Glu 
            180                 185                 190         
Thr Glu Glu Gln Phe Val Ala Arg Leu Ala His Glu Leu Glu Glu Thr 
        195                 200                 205             
Ile Gln Lys Glu Gly Ala Asp Thr Ile Ala Gly Phe Phe Ala Glu Pro 
    210                 215                 220                 
Val Met Gly Ala Gly Gly Val Ile Pro Pro Ala Lys Gly Tyr Phe Gln 
225                 230                 235                 240 
Ala Ile Leu Pro Ile Leu Arg Lys Tyr Asp Ile Pro Val Ile Ser Asp 
                245                 250                 255     
Glu Val Ile Cys Gly Phe Gly Arg Thr Gly Asn Thr Trp Gly Cys Val 
            260                 265                 270         
Thr Tyr Asp Phe Thr Pro Asp Ala Ile Ile Ser Ser Lys Ser Leu Thr 
        275                 280                 285             
Ala Gly Phe Phe Pro Val Gly Ala Val Ile Leu Gly Pro Glu Leu Ser 
    290                 295                 300                 
Lys Arg Leu Glu Thr Ala Ile Glu Ala Arg Glu Trp Phe Pro His Gly 
305                 310                 315                 320 
Phe Thr Thr Gly Gly His Pro Val Gly Cys Ala Ile Ala Leu Lys Ala 
                325                 330                 335     
Ile Asp Val Val Met Asn Glu Gly Leu Ala Glu Asn Val Arg Arg Leu 
            340                 345                 350         
Ala Pro Arg Phe Glu Glu Arg Leu Lys His Ile Ala Glu Arg Pro Asn 
        355                 360                 365             
Ile Gly Glu Tyr Arg Gly Ile Gly Phe Met Trp Ala Leu Glu Val Val 
    370                 375                 380                 
Lys Asp Lys Ala Ser Lys Ala Pro Phe Gly Gly Asn Leu Ser Val Ser 
385                 390                 395                 400 
Glu Arg Ile Ala Asn Thr Cys Thr Asp Leu Gly Leu Ile Val Arg Ser 
                405                 410                 415     
Met Gly Gln Ser Val Ala Leu Cys Pro Pro Phe Ile Leu Thr Glu Ala 
            420                 425                 430         
Gln Met Asp Glu Met Phe Asp Lys Leu Glu Lys Ala Leu Asp Lys Val 
        435                 440                 445             
Phe Ala Glu Val Ala                                             
    450                                                         

 
<210> 29
<211> 1359
<212> DNA
<213> Artificial Sequence
 
<220>
<223> variant of transaminase from Vibrio fluvialis Js17
 
<400> 29
atgaacaaac cgcagagctg ggaaacgcgt gcggaaacct atagcctgta tggttttacc 60
gatatgccga gcctgcatca gcgtggcacc gtggtggtga cccatggcga aggcccgtat 120
atcgtggatg tgcatggccg tcgttatctg gatgcgaaca gcggcgctct gaacatggtg 180
gcgggctttg atcataaagg cctgattgat gcggcgaaaa cgcagtatga acgttttccg 240
ggctatcatg cggttgcggg ccgtatgagc gatcagaccg tgatgctgtc tgaaaaactg 300
gtggaagtga gcccgtttga tagcggccgt gtgttttata ccaacagcgg cagcgaagcg 360
aacgatacca tggtgaaaat gctgtggttt ctgcatgcgg cggaaggcaa accgcagaaa 420
cgtaaaattc tgacccgttg gaacgcgtat catggcgcga ccgcggtgag cgcgagcatg 480
accggctttc cgtataacag cgtgtttggc ctgccgctgc cgggctttct gcatctgacc 540
tgcccgcatt attggcgtta tggcgaagaa ggcgaaaccg aagaacagtt tgtcgcgcgt 600
ctggcccatg aactggaaga aaccattcag aaggaaggcg cggataccat tgcgggcttt 660
tttgcggaac cggtgatggg tgcgggcggt gttattccgc cggcaaaagg ctattttcag 720
gcgattctgc cgatcctgcg caaatatgat attccggtga tcagcgatga agtgatttgc 780
ggcttcggcc gtaccggtaa cacctggggc tgcgtgacct atgattttac cccggatgcg 840
attattagca gtaaaagcct aaccgcgggt ttttttccgg taggcgcggt gattctgggt 900
ccggaactga gcaaacgtct ggaaaccgcg attgaagcgc gtgaatggtt tccgcatggt 960
tttaccacag gcggccatcc ggtgggttgt gcgattgcgc tgaaagcgat tgatgtggtg 1020
atgaacgaag gcctggccga aaacgtgcgt cgtctggccc cgcgttttga agaacgtctg 1080
aaacatattg cggaacgtcc gaacattggc gaatatcgtg gcattggctt tatgtgggcg 1140
ctggaagtcg tgaaagataa agcgagcaaa gccccgtttg gtggcaacct gagcgtgagc 1200
gaacgtattg cgaacacctg caccgatctg ggcctgattg tgcgtgcgct gggccagagc 1260
gtggcgctgt gcccgccgtt tattctgacc gaagcgcaga tggatgaaat gttcgataaa 1320
ctggaaaaag cgctggataa agtgttcgcg gaagtggcg                        1359

 
<210> 30
<211> 453
<212> PRT
<213> Artificial Sequence
 
<220>
<223> variant of transaminase from Vibrio fluvialis Js17
 
<400> 30
Met Asn Lys Pro Gln Ser Trp Glu Thr Arg Ala Glu Thr Tyr Ser Leu 
1               5                   10                  15      
Tyr Gly Phe Thr Asp Met Pro Ser Leu His Gln Arg Gly Thr Val Val 
            20                  25                  30          
Val Thr His Gly Glu Gly Pro Tyr Ile Val Asp Val His Gly Arg Arg 
        35                  40                  45              
Tyr Leu Asp Ala Asn Ser Gly Ala Leu Asn Met Val Ala Gly Phe Asp 
    50                  55                  60                  
His Lys Gly Leu Ile Asp Ala Ala Lys Thr Gln Tyr Glu Arg Phe Pro 
65                  70                  75                  80  
Gly Tyr His Ala Val Ala Gly Arg Met Ser Asp Gln Thr Val Met Leu 
                85                  90                  95      
Ser Glu Lys Leu Val Glu Val Ser Pro Phe Asp Ser Gly Arg Val Phe 
            100                 105                 110         
Tyr Thr Asn Ser Gly Ser Glu Ala Asn Asp Thr Met Val Lys Met Leu 
        115                 120                 125             
Trp Phe Leu His Ala Ala Glu Gly Lys Pro Gln Lys Arg Lys Ile Leu 
    130                 135                 140                 
Thr Arg Trp Asn Ala Tyr His Gly Ala Thr Ala Val Ser Ala Ser Met 
145                 150                 155                 160 
Thr Gly Phe Pro Tyr Asn Ser Val Phe Gly Leu Pro Leu Pro Gly Phe 
                165                 170                 175     
Leu His Leu Thr Cys Pro His Tyr Trp Arg Tyr Gly Glu Glu Gly Glu 
            180                 185                 190         
Thr Glu Glu Gln Phe Val Ala Arg Leu Ala His Glu Leu Glu Glu Thr 
        195                 200                 205             
Ile Gln Lys Glu Gly Ala Asp Thr Ile Ala Gly Phe Phe Ala Glu Pro 
    210                 215                 220                 
Val Met Gly Ala Gly Gly Val Ile Pro Pro Ala Lys Gly Tyr Phe Gln 
225                 230                 235                 240 
Ala Ile Leu Pro Ile Leu Arg Lys Tyr Asp Ile Pro Val Ile Ser Asp 
                245                 250                 255     
Glu Val Ile Cys Gly Phe Gly Arg Thr Gly Asn Thr Trp Gly Cys Val 
            260                 265                 270         
Thr Tyr Asp Phe Thr Pro Asp Ala Ile Ile Ser Ser Lys Ser Leu Thr 
        275                 280                 285             
Ala Gly Phe Phe Pro Val Gly Ala Val Ile Leu Gly Pro Glu Leu Ser 
    290                 295                 300                 
Lys Arg Leu Glu Thr Ala Ile Glu Ala Arg Glu Trp Phe Pro His Gly 
305                 310                 315                 320 
Phe Thr Thr Gly Gly His Pro Val Gly Cys Ala Ile Ala Leu Lys Ala 
                325                 330                 335     
Ile Asp Val Val Met Asn Glu Gly Leu Ala Glu Asn Val Arg Arg Leu 
            340                 345                 350         
Ala Pro Arg Phe Glu Glu Arg Leu Lys His Ile Ala Glu Arg Pro Asn 
        355                 360                 365             
Ile Gly Glu Tyr Arg Gly Ile Gly Phe Met Trp Ala Leu Glu Val Val 
    370                 375                 380                 
Lys Asp Lys Ala Ser Lys Ala Pro Phe Gly Gly Asn Leu Ser Val Ser 
385                 390                 395                 400 
Glu Arg Ile Ala Asn Thr Cys Thr Asp Leu Gly Leu Ile Val Arg Ala 
                405                 410                 415     
Leu Gly Gln Ser Val Ala Leu Cys Pro Pro Phe Ile Leu Thr Glu Ala 
            420                 425                 430         
Gln Met Asp Glu Met Phe Asp Lys Leu Glu Lys Ala Leu Asp Lys Val 
        435                 440                 445             
Phe Ala Glu Val Ala                                             
    450                                                         

 
<210> 31
<211> 1359
<212> DNA
<213> Artificial Sequence
 
<220>
<223> variant of transaminase from Vibrio fluvialis Js17
 
<400> 31
atgaacaaac cgcagagctg ggaaacgcgt gcggaaacct atagcctgta tggttttacc 60
gatatgccga gcctgcatca gcgtggcacc gtggtggtga cccatggcga aggcccgtat 120
atcgtggatg tgcatggccg tcgttatctg gatgcgaaca gcggcgctct gaacatggtg 180
gcgggctttg atcataaagg cctgattgat gcggcgaaaa cgcagtatga acgttttccg 240
ggctatcatg cggttgcggg ccgtatgagc gatcagaccg tgatgctgtc tgaaaaactg 300
gtggaagtga gcccgtttga tagcggccgt gtgttttata ccaacagcgg cagcgaagcg 360
aacgatacca tggtgaaaat gctgtggttt ctgcatgcgg cggaaggcaa accgcagaaa 420
cgtaaaattc tgacccgttg gaacgcgtat catggcgcga ccgcggtgag cgcgagcatg 480
accggctttc cgtataacag cgtgtttggc ctgccgctgc cgggctttct gcatctgacc 540
tgcccgcatt attggcgtta tggcgaagaa ggcgaaaccg aaaaacagtt tgtcgcgcgt 600
ctggcccatg aactggaaga aaccattcag aaggaaggcg cggataccat tgcgggcttt 660
tttgcggaac cggtgatgtt tgcgggcggt gttattccgc cggcaaaagg ctattttcag 720
gcgattctgc cgatcctgcg caaatatgat attccggtga tcagcgatga agtgatttgc 780
ggcttcggcc gtaccggtaa cacctggggc tgcgtgacct atgattttac cccggatgcg 840
attattagca gtaaaagcct aaccgcgggt ttttttccgg taggcgcggt gattctgggt 900
ccggaactga gcaaacgtct ggaaaccgcg attgaagcgc gtgaatggtt tccgcatggt 960
tttaccacag gcggccatcc ggtgggttgt gcgattgcgc tgaaagcgat tgatgtggtg 1020
atgaacgaag gcctggccga aaacgtgcgt cgtctggccc cgcgttttga agaacgtctg 1080
aaacatattg cggaacgtcc gaacattggc gaatatcgtg gcattggctt tatgtgggcg 1140
ctggaagtcg tgaaagataa agcgagcaaa gccccgtttg gtggcaacct gagcgtgagc 1200
gaacgtattg cgaacacctg caccgatctg ggcctgattt gccgtgcgct gggccagagc 1260
gtggttctgt gcccgccgtt tattctgacc gaagcgcaga tggatgaaat gttcgataaa 1320
ctggaaaaag cgctggataa agtgttcgcg gaagtggcg                        1359

 
<210> 32
<211> 453
<212> PRT
<213> Artificial Sequence
 
<220>
<223> variant of transaminase from Vibrio fluvialis Js17
 
<400> 32
Met Asn Lys Pro Gln Ser Trp Glu Thr Arg Ala Glu Thr Tyr Ser Leu 
1               5                   10                  15      
Tyr Gly Phe Thr Asp Met Pro Ser Leu His Gln Arg Gly Thr Val Val 
            20                  25                  30          
Val Thr His Gly Glu Gly Pro Tyr Ile Val Asp Val His Gly Arg Arg 
        35                  40                  45              
Tyr Leu Asp Ala Asn Ser Gly Ala Leu Asn Met Val Ala Gly Phe Asp 
    50                  55                  60                  
His Lys Gly Leu Ile Asp Ala Ala Lys Thr Gln Tyr Glu Arg Phe Pro 
65                  70                  75                  80  
Gly Tyr His Ala Val Ala Gly Arg Met Ser Asp Gln Thr Val Met Leu 
                85                  90                  95      
Ser Glu Lys Leu Val Glu Val Ser Pro Phe Asp Ser Gly Arg Val Phe 
            100                 105                 110         
Tyr Thr Asn Ser Gly Ser Glu Ala Asn Asp Thr Met Val Lys Met Leu 
        115                 120                 125             
Trp Phe Leu His Ala Ala Glu Gly Lys Pro Gln Lys Arg Lys Ile Leu 
    130                 135                 140                 
Thr Arg Trp Asn Ala Tyr His Gly Ala Thr Ala Val Ser Ala Ser Met 
145                 150                 155                 160 
Thr Gly Phe Pro Tyr Asn Ser Val Phe Gly Leu Pro Leu Pro Gly Phe 
                165                 170                 175     
Leu His Leu Thr Cys Pro His Tyr Trp Arg Tyr Gly Glu Glu Gly Glu 
            180                 185                 190         
Thr Glu Lys Gln Phe Val Ala Arg Leu Ala His Glu Leu Glu Glu Thr 
        195                 200                 205             
Ile Gln Lys Glu Gly Ala Asp Thr Ile Ala Gly Phe Phe Ala Glu Pro 
    210                 215                 220                 
Val Met Phe Ala Gly Gly Val Ile Pro Pro Ala Lys Gly Tyr Phe Gln 
225                 230                 235                 240 
Ala Ile Leu Pro Ile Leu Arg Lys Tyr Asp Ile Pro Val Ile Ser Asp 
                245                 250                 255     
Glu Val Ile Cys Gly Phe Gly Arg Thr Gly Asn Thr Trp Gly Cys Val 
            260                 265                 270         
Thr Tyr Asp Phe Thr Pro Asp Ala Ile Ile Ser Ser Lys Ser Leu Thr 
        275                 280                 285             
Ala Gly Phe Phe Pro Val Gly Ala Val Ile Leu Gly Pro Glu Leu Ser 
    290                 295                 300                 
Lys Arg Leu Glu Thr Ala Ile Glu Ala Arg Glu Trp Phe Pro His Gly 
305                 310                 315                 320 
Phe Thr Thr Gly Gly His Pro Val Gly Cys Ala Ile Ala Leu Lys Ala 
                325                 330                 335     
Ile Asp Val Val Met Asn Glu Gly Leu Ala Glu Asn Val Arg Arg Leu 
            340                 345                 350         
Ala Pro Arg Phe Glu Glu Arg Leu Lys His Ile Ala Glu Arg Pro Asn 
        355                 360                 365             
Ile Gly Glu Tyr Arg Gly Ile Gly Phe Met Trp Ala Leu Glu Val Val 
    370                 375                 380                 
Lys Asp Lys Ala Ser Lys Ala Pro Phe Gly Gly Asn Leu Ser Val Ser 
385                 390                 395                 400 
Glu Arg Ile Ala Asn Thr Cys Thr Asp Leu Gly Leu Ile Cys Arg Ala 
                405                 410                 415     
Leu Gly Gln Ser Val Val Leu Cys Pro Pro Phe Ile Leu Thr Glu Ala 
            420                 425                 430         
Gln Met Asp Glu Met Phe Asp Lys Leu Glu Lys Ala Leu Asp Lys Val 
        435                 440                 445             
Phe Ala Glu Val Ala                                             
    450                                                         

 
<210> 33
<211> 1359
<212> DNA
<213> Artificial Sequence
 
<220>
<223> variant of transaminase from Vibrio fluvialis Js17
 
<400> 33
atgaacaaac cgcagagctg ggaaacgcgt gcggaaacct atagcctgta tggttttacc 60
gatatgccga gcctgcatca gcgtggcacc gtggtggtga cccatggcga aggcccgtat 120
atcgtggatg tgcatggccg tcgttatctg gatgcgaaca gcggcgctct gaacatggtg 180
gcgggctttg atcataaagg cctgattgat gcggcgaaaa cgcagtatga acgttttccg 240
ggctatcatg cggttgcggg ccgtatgagc gatcagaccg tgatgctgtc tgaaaaactg 300
gtggaagtga gcccgtttga tagcggccgt gtgttttata ccaacagcgg cagcgaagcg 360
aacgatacca tggtgaaaat gctgtggttt ctgcatgcgg cggaaggcaa accgcagaaa 420
cgtaaaattc tgacccgttg gaacgcgtat catggcgcga ccgcggtgag cgcgagcatg 480
accggctttc cgtataacag cgtgtttggc ctgccgctgc cgggctttct gcatctgacc 540
tgcccgcatt attggcgtta tggcgaagaa ggcgaaaccg aagaacagtt tgtcgcgcgt 600
ctggcccatg aactggaaga aaccattcag aaggaaggcg cggataccat tgcgggcttt 660
tttgcggaac cggtgatggg tgcgggcggt gttattccgc cggcaaaagg ctattttcag 720
gcgattctgc cgatcctgcg caaatatgat attccggtga tcagcgatga agtgatttgc 780
ggcttcggcc gtaccggtaa cacctggggc tgcgtgacct atgattttac cccggatgcg 840
attattagca gtaaaagcct aaccgcgggt ttttttccgg taggcgcggt gattctgggt 900
ccggaactga gcaaacgtct ggaaaccgcg attgaagcga tcgaaatgtt tccgcatggt 960
tttagtacag gcggccatcc ggtgggttgt gcgattgcgc tgaaagcgat tgatgtggtg 1020
atgaacgaag gcctggccga aaacgtgcgt cgtctggccc cgcgttttga agaacgtctg 1080
aaacatattg cggaacgtcc gaacattggc gaatatcgtg gcattggctt tatgtgggcg 1140
ctggaagtcg tgaaagataa agcgagcaaa gccccgtttg gtggcaacct gagcgtgagc 1200
gaacgtattg cgaacacctg caccgatctg ggcctgattt gccgtggcct gggccagagc 1260
gtggttctgt gcccgccgtt tattctgacc gaagcgcaga tggatgaaat gttcgataaa 1320
ctggaaaaag cgctggataa agtgttcgcg gaagtggcg                        1359

 
<210> 34
<211> 453
<212> PRT
<213> Artificial Sequence
 
<220>
<223> variant of transaminase from Vibrio fluvialis Js17
 
<400> 34
Met Asn Lys Pro Gln Ser Trp Glu Thr Arg Ala Glu Thr Tyr Ser Leu 
1               5                   10                  15      
Tyr Gly Phe Thr Asp Met Pro Ser Leu His Gln Arg Gly Thr Val Val 
            20                  25                  30          
Val Thr His Gly Glu Gly Pro Tyr Ile Val Asp Val His Gly Arg Arg 
        35                  40                  45              
Tyr Leu Asp Ala Asn Ser Gly Ala Leu Asn Met Val Ala Gly Phe Asp 
    50                  55                  60                  
His Lys Gly Leu Ile Asp Ala Ala Lys Thr Gln Tyr Glu Arg Phe Pro 
65                  70                  75                  80  
Gly Tyr His Ala Val Ala Gly Arg Met Ser Asp Gln Thr Val Met Leu 
                85                  90                  95      
Ser Glu Lys Leu Val Glu Val Ser Pro Phe Asp Ser Gly Arg Val Phe 
            100                 105                 110         
Tyr Thr Asn Ser Gly Ser Glu Ala Asn Asp Thr Met Val Lys Met Leu 
        115                 120                 125             
Trp Phe Leu His Ala Ala Glu Gly Lys Pro Gln Lys Arg Lys Ile Leu 
    130                 135                 140                 
Thr Arg Trp Asn Ala Tyr His Gly Ala Thr Ala Val Ser Ala Ser Met 
145                 150                 155                 160 
Thr Gly Phe Pro Tyr Asn Ser Val Phe Gly Leu Pro Leu Pro Gly Phe 
                165                 170                 175     
Leu His Leu Thr Cys Pro His Tyr Trp Arg Tyr Gly Glu Glu Gly Glu 
            180                 185                 190         
Thr Glu Glu Gln Phe Val Ala Arg Leu Ala His Glu Leu Glu Glu Thr 
        195                 200                 205             
Ile Gln Lys Glu Gly Ala Asp Thr Ile Ala Gly Phe Phe Ala Glu Pro 
    210                 215                 220                 
Val Met Gly Ala Gly Gly Val Ile Pro Pro Ala Lys Gly Tyr Phe Gln 
225                 230                 235                 240 
Ala Ile Leu Pro Ile Leu Arg Lys Tyr Asp Ile Pro Val Ile Ser Asp 
                245                 250                 255     
Glu Val Ile Cys Gly Phe Gly Arg Thr Gly Asn Thr Trp Gly Cys Val 
            260                 265                 270         
Thr Tyr Asp Phe Thr Pro Asp Ala Ile Ile Ser Ser Lys Ser Leu Thr 
        275                 280                 285             
Ala Gly Phe Phe Pro Val Gly Ala Val Ile Leu Gly Pro Glu Leu Ser 
    290                 295                 300                 
Lys Arg Leu Glu Thr Ala Ile Glu Ala Ile Glu Met Phe Pro His Gly 
305                 310                 315                 320 
Phe Ser Thr Gly Gly His Pro Val Gly Cys Ala Ile Ala Leu Lys Ala 
                325                 330                 335     
Ile Asp Val Val Met Asn Glu Gly Leu Ala Glu Asn Val Arg Arg Leu 
            340                 345                 350         
Ala Pro Arg Phe Glu Glu Arg Leu Lys His Ile Ala Glu Arg Pro Asn 
        355                 360                 365             
Ile Gly Glu Tyr Arg Gly Ile Gly Phe Met Trp Ala Leu Glu Val Val 
    370                 375                 380                 
Lys Asp Lys Ala Ser Lys Ala Pro Phe Gly Gly Asn Leu Ser Val Ser 
385                 390                 395                 400 
Glu Arg Ile Ala Asn Thr Cys Thr Asp Leu Gly Leu Ile Cys Arg Gly 
                405                 410                 415     
Leu Gly Gln Ser Val Val Leu Cys Pro Pro Phe Ile Leu Thr Glu Ala 
            420                 425                 430         
Gln Met Asp Glu Met Phe Asp Lys Leu Glu Lys Ala Leu Asp Lys Val 
        435                 440                 445             
Phe Ala Glu Val Ala                                             
    450                                                         

 
<210> 35
<211> 1359
<212> DNA
<213> Artificial Sequence
 
<220>
<223> variant of transaminase from Vibrio fluvialis Js17
 
<400> 35
atgaacaaac cgcagagctg ggaaacgcgt gcggaaacct atagcctgta tggttttacc 60
gatatgccga gcctgcatca gcgtggcacc gtggtggtga cccatggcga aggcccgtat 120
atcgtggatg tgcatggccg tcgttatctg gatgcgaaca gcggcgctct gaacatggtg 180
gcgggctttg atcataaagg cctgattgat gcggcgaaaa cgcagtatga acgttttccg 240
ggctatcatg cggttgcggg ccgtatgagc gatcagaccg tgatgctgtc tgaaaaactg 300
gtggaagtga gcccgtttga tagcggccgt gtgttttata ccaacagcgg cagcgaagcg 360
aacgatacca tggtgaaaat gctgtggttt ctgcatgcgg cggaaggcaa accgcagaaa 420
cgtaaaattc tgaccgtttg gaacgcgtat catggcgcga ccgcggtggg ggcgagcatg 480
accggctttc cgtataacag cgtgtttggc ctgccgctgc cgggctttct gcatctgacc 540
tgcccgcatt attggcgtta tggcgaagaa ggcgaaaccg aagaacagtt tgtcgcgcgt 600
ctggcccatg aactggaaga aaccattcag aaggaaggcg cggataccat tgcgggcttt 660
tttgcggaac cggtgatggg tgcgggcggt gttattccgc cggcaaaagg ctattttcag 720
gcgattctgc cgatcctgcg caaatatgat attccggtga tcagcgatga agtgatttgc 780
ggcttcggcc gtaccggtaa cacctggggc tgcgtgacct atgattttac cccggatgcg 840
attattagca gtaaaagcct aaccgcgggt ttttttccgg taggcgcggt gattctgggt 900
ccggaactga gcaaacgtct ggaaaccgcg attgaagcga tcgaaatgtt tccgcatggt 960
tttaccacag gcggccatcc ggtgggttgt gcgattgcgc tgaaagcgat tgatgtggtg 1020
atgaacgaag gcctggccga aaacgtgcgt cgtctggccc cgcgttttga agaacgtctg 1080
aaacatattg cggaacgtcc gaacattggc gaatatcgtg gcattggctt tatgtgggcg 1140
ctggaagtcg tgaaagataa agcgagcaaa gccccgtttg gtggcaacct gagcgtgagc 1200
gaacgtattg cgaacacctg caccgatctg ggcctgattt gccgtggcct gggccagagc 1260
gtggttctgt gcccgccgtt tattctgacc gaagcgcaga tggatgaaat gttcgataaa 1320
ctggaaaaag cgctggataa agtgttcgcg gaagtggcg                        1359

 
<210> 36
<211> 453
<212> PRT
<213> Artificial Sequence
 
<220>
<223> variant of transaminase from Vibrio fluvialis Js17
 
<400> 36
Met Asn Lys Pro Gln Ser Trp Glu Thr Arg Ala Glu Thr Tyr Ser Leu 
1               5                   10                  15      
Tyr Gly Phe Thr Asp Met Pro Ser Leu His Gln Arg Gly Thr Val Val 
            20                  25                  30          
Val Thr His Gly Glu Gly Pro Tyr Ile Val Asp Val His Gly Arg Arg 
        35                  40                  45              
Tyr Leu Asp Ala Asn Ser Gly Ala Leu Asn Met Val Ala Gly Phe Asp 
    50                  55                  60                  
His Lys Gly Leu Ile Asp Ala Ala Lys Thr Gln Tyr Glu Arg Phe Pro 
65                  70                  75                  80  
Gly Tyr His Ala Val Ala Gly Arg Met Ser Asp Gln Thr Val Met Leu 
                85                  90                  95      
Ser Glu Lys Leu Val Glu Val Ser Pro Phe Asp Ser Gly Arg Val Phe 
            100                 105                 110         
Tyr Thr Asn Ser Gly Ser Glu Ala Asn Asp Thr Met Val Lys Met Leu 
        115                 120                 125             
Trp Phe Leu His Ala Ala Glu Gly Lys Pro Gln Lys Arg Lys Ile Leu 
    130                 135                 140                 
Thr Val Trp Asn Ala Tyr His Gly Ala Thr Ala Val Gly Ala Ser Met 
145                 150                 155                 160 
Thr Gly Phe Pro Tyr Asn Ser Val Phe Gly Leu Pro Leu Pro Gly Phe 
                165                 170                 175     
Leu His Leu Thr Cys Pro His Tyr Trp Arg Tyr Gly Glu Glu Gly Glu 
            180                 185                 190         
Thr Glu Glu Gln Phe Val Ala Arg Leu Ala His Glu Leu Glu Glu Thr 
        195                 200                 205             
Ile Gln Lys Glu Gly Ala Asp Thr Ile Ala Gly Phe Phe Ala Glu Pro 
    210                 215                 220                 
Val Met Gly Ala Gly Gly Val Ile Pro Pro Ala Lys Gly Tyr Phe Gln 
225                 230                 235                 240 
Ala Ile Leu Pro Ile Leu Arg Lys Tyr Asp Ile Pro Val Ile Ser Asp 
                245                 250                 255     
Glu Val Ile Cys Gly Phe Gly Arg Thr Gly Asn Thr Trp Gly Cys Val 
            260                 265                 270         
Thr Tyr Asp Phe Thr Pro Asp Ala Ile Ile Ser Ser Lys Ser Leu Thr 
        275                 280                 285             
Ala Gly Phe Phe Pro Val Gly Ala Val Ile Leu Gly Pro Glu Leu Ser 
    290                 295                 300                 
Lys Arg Leu Glu Thr Ala Ile Glu Ala Ile Glu Met Phe Pro His Gly 
305                 310                 315                 320 
Phe Thr Thr Gly Gly His Pro Val Gly Cys Ala Ile Ala Leu Lys Ala 
                325                 330                 335     
Ile Asp Val Val Met Asn Glu Gly Leu Ala Glu Asn Val Arg Arg Leu 
            340                 345                 350         
Ala Pro Arg Phe Glu Glu Arg Leu Lys His Ile Ala Glu Arg Pro Asn 
        355                 360                 365             
Ile Gly Glu Tyr Arg Gly Ile Gly Phe Met Trp Ala Leu Glu Val Val 
    370                 375                 380                 
Lys Asp Lys Ala Ser Lys Ala Pro Phe Gly Gly Asn Leu Ser Val Ser 
385                 390                 395                 400 
Glu Arg Ile Ala Asn Thr Cys Thr Asp Leu Gly Leu Ile Cys Arg Gly 
                405                 410                 415     
Leu Gly Gln Ser Val Val Leu Cys Pro Pro Phe Ile Leu Thr Glu Ala 
            420                 425                 430         
Gln Met Asp Glu Met Phe Asp Lys Leu Glu Lys Ala Leu Asp Lys Val 
        435                 440                 445             
Phe Ala Glu Val Ala                                             
    450                                                         

 
<210> 37
<211> 1359
<212> DNA
<213> Artificial Sequence
 
<220>
<223> variant of transaminase from Vibrio fluvialis Js17
 
<400> 37
atgaacaaac cgcagagctg ggaaacgcgt gcggaaacct atagcctgta tggttttacc 60
gatatgccga gcctgcatca gcgtggcacc gtggtggtga cccatggcga aggcccgtat 120
atcgtggatg tgcatggccg tcgttatctg gatgcgaaca gcggcgctgc gaacatggtg 180
gcgggctttg atcataaagg cctgattgat gcggcgaaaa cgcagtatga acgttttccg 240
ggctatcatg cggttaaagg ccgtatgagc gatcagaccg tgatgctgtc tgaaaaactg 300
gtggaagtga gcccgtttga tagcggccgt gtgttttata ccaacagcgg cagcgaagcg 360
tgcgatacca tggtgaaaat gctgtggttt ctgcatgcgg cggaaggcaa accgcagaaa 420
cgtaaaattc tgaccaaatg gaacgcgtat catggcgcga ccgcggtggg cgcgagcatg 480
accggctttc cgtataacag cgtgtttggc ctgccgctgc cgggctttct gcatctgacc 540
tgcccgcatt attggcgtta tggcgaagaa ggcgaaaccg aagaacagtt tgtcgcgcgt 600
ctggcccatg aactggaaga aaccattcag aaggaaggcg cggataccat tgcgggcttt 660
tttgcggaac cggtgatggg tgcgggcggt gttattccgc cggcaaaagg ctattttcag 720
gcgattctgc cgatcctgcg caaatatgat attccggtga tcagcgatga agtgatttgc 780
ggcttcggcc gtaccggtaa cacctggggc tgcgtgacct atgattttac cccggatgcg 840
attattagca gtaaaagcct aaccgcgggt ttttttccgg taggcgcggt gattctgggt 900
ccggaactga gcaaacgtct ggaaaccgcg attgaagcgc gtgaatggtt tccgcatggt 960
tttaccacag gcggccatcc ggtgggttgt gcgattgcgc tgaaagcgat tgatgtggtg 1020
atgaacgaag gcctggccga aaacgtgcgt cgtctggccc cgcgttttga agaacgtctg 1080
aaacatattg cggaacgtcc gaacattggc gaatatcgtg gcattggctt tatgtgggcg 1140
ctggaagtcg tgaaagataa agcgagcaaa gccccgtttg gtggcaacct gagcgtgagc 1200
gaacgtattg cgaacacctg caccgatctg ggcctgattg tgcgtgcgct gggccagagc 1260
gtggcgctgt gcccgccgtt tattctgacc gaagcgcaga tggatgaaat gttcgataaa 1320
ctggaaaaag cgctggataa agtgttcgcg gaagtggcg                        1359

 
<210> 38
<211> 453
<212> PRT
<213> Artificial Sequence
 
<220>
<223> variant of transaminase from Vibrio fluvialis Js17
 
<400> 38
Met Asn Lys Pro Gln Ser Trp Glu Thr Arg Ala Glu Thr Tyr Ser Leu 
1               5                   10                  15      
Tyr Gly Phe Thr Asp Met Pro Ser Leu His Gln Arg Gly Thr Val Val 
            20                  25                  30          
Val Thr His Gly Glu Gly Pro Tyr Ile Val Asp Val His Gly Arg Arg 
        35                  40                  45              
Tyr Leu Asp Ala Asn Ser Gly Ala Ala Asn Met Val Ala Gly Phe Asp 
    50                  55                  60                  
His Lys Gly Leu Ile Asp Ala Ala Lys Thr Gln Tyr Glu Arg Phe Pro 
65                  70                  75                  80  
Gly Tyr His Ala Val Lys Gly Arg Met Ser Asp Gln Thr Val Met Leu 
                85                  90                  95      
Ser Glu Lys Leu Val Glu Val Ser Pro Phe Asp Ser Gly Arg Val Phe 
            100                 105                 110         
Tyr Thr Asn Ser Gly Ser Glu Ala Cys Asp Thr Met Val Lys Met Leu 
        115                 120                 125             
Trp Phe Leu His Ala Ala Glu Gly Lys Pro Gln Lys Arg Lys Ile Leu 
    130                 135                 140                 
Thr Lys Trp Asn Ala Tyr His Gly Ala Thr Ala Val Gly Ala Ser Met 
145                 150                 155                 160 
Thr Gly Phe Pro Tyr Asn Ser Val Phe Gly Leu Pro Leu Pro Gly Phe 
                165                 170                 175     
Leu His Leu Thr Cys Pro His Tyr Trp Arg Tyr Gly Glu Glu Gly Glu 
            180                 185                 190         
Thr Glu Glu Gln Phe Val Ala Arg Leu Ala His Glu Leu Glu Glu Thr 
        195                 200                 205             
Ile Gln Lys Glu Gly Ala Asp Thr Ile Ala Gly Phe Phe Ala Glu Pro 
    210                 215                 220                 
Val Met Gly Ala Gly Gly Val Ile Pro Pro Ala Lys Gly Tyr Phe Gln 
225                 230                 235                 240 
Ala Ile Leu Pro Ile Leu Arg Lys Tyr Asp Ile Pro Val Ile Ser Asp 
                245                 250                 255     
Glu Val Ile Cys Gly Phe Gly Arg Thr Gly Asn Thr Trp Gly Cys Val 
            260                 265                 270         
Thr Tyr Asp Phe Thr Pro Asp Ala Ile Ile Ser Ser Lys Ser Leu Thr 
        275                 280                 285             
Ala Gly Phe Phe Pro Val Gly Ala Val Ile Leu Gly Pro Glu Leu Ser 
    290                 295                 300                 
Lys Arg Leu Glu Thr Ala Ile Glu Ala Arg Glu Trp Phe Pro His Gly 
305                 310                 315                 320 
Phe Thr Thr Gly Gly His Pro Val Gly Cys Ala Ile Ala Leu Lys Ala 
                325                 330                 335     
Ile Asp Val Val Met Asn Glu Gly Leu Ala Glu Asn Val Arg Arg Leu 
            340                 345                 350         
Ala Pro Arg Phe Glu Glu Arg Leu Lys His Ile Ala Glu Arg Pro Asn 
        355                 360                 365             
Ile Gly Glu Tyr Arg Gly Ile Gly Phe Met Trp Ala Leu Glu Val Val 
    370                 375                 380                 
Lys Asp Lys Ala Ser Lys Ala Pro Phe Gly Gly Asn Leu Ser Val Ser 
385                 390                 395                 400 
Glu Arg Ile Ala Asn Thr Cys Thr Asp Leu Gly Leu Ile Val Arg Ala 
                405                 410                 415     
Leu Gly Gln Ser Val Ala Leu Cys Pro Pro Phe Ile Leu Thr Glu Ala 
            420                 425                 430         
Gln Met Asp Glu Met Phe Asp Lys Leu Glu Lys Ala Leu Asp Lys Val 
        435                 440                 445             
Phe Ala Glu Val Ala                                             
    450                                                         

 
<210> 39
<211> 1359
<212> DNA
<213> Artificial Sequence
 
<220>
<223> variant of transaminase from Vibrio fluvialis Js17
 
<400> 39
atgaacaaac cgcagagctg ggaaacgcgt gcggaaacct atagcctgta tggttttacc 60
gatatgccga gcctgcatca gcgtggcacc gtggtggtga cccatggcga aggcccgtat 120
atcgtggatg tgcatggccg tcgttatctg gatgcgaaca gcggcgctct gaacatggtg 180
gcgggctttg atcataaagg cctgattgat gcggcgaaaa cgcagtatga acgttttccg 240
ggctatcatg cggttaaagg ccgtatgagc gatcagaccg tgatgctgtc tgaaaaactg 300
gtggaagtga gcccgtttga tagcggccgt gtgttttata ccaacagcgg cagcgaagcg 360
aacgatacca tggtgaaaat gctgtggttt ctgcatgcgg cggaaggcaa accgcagaaa 420
cgtaaaattc tgacccgttg gaacgcgtat catggcgcga ccgcggtgag cgcgagcatg 480
accggctttc cgtataacag cgtgtttggc ctgccgctgc cgggctttct gcatctgacc 540
tgcccgcatt attggcgtta tggcgaagaa ggcgaaaccg aagaacagtt tgtcgcgcgt 600
ctggcccatg aactggaaga aaccattcag aaggaaggcg cggataccat tgcgggcttt 660
tttgcggaac cggtgatggg tgcgggcggt gttattccgc cggcaaaagg ctattttcag 720
gcgattctgc cgatcctgcg caaatatgat attccggtga tcagcgatga agtgatttgc 780
ggcttcggcc gtaccggtaa cacctggggc tgcgtgacct atgattttac cccggatgcg 840
attattagca gtaaaagcct aaccgcgggt ttttttccgg taggcgcggt gattctgggt 900
ccggaactga gcaaacgtct ggaaaccgcg attgaagcgc gtgaatggtt tccgcatggt 960
tttaccacag gcggccatcc ggtgggttgt gcgattgcgc tgaaagcgat tgatgtggtg 1020
atgaacgaag gcctggccga aaacgtgcgt cgtctggccc cgcgttttga agaacgtctg 1080
aaacatattg cggaacgtcc gaacattggc gaatatcgtg gcattggctt tatgtgggcg 1140
ctggaagtcg tgaaagataa agcgagcaaa gccccgtttg gtggcaacct gagcgtgagc 1200
gaacgtattg cgaacacctg caccgatctg ggcctgattg tgcgtgcgct gggccagagc 1260
gtggcgctgt gcccgccgtt tattctgacc gaagcgcaga tggatgaaat gttcgataaa 1320
ctggaaaaag cgctggataa agtgttcgcg gaagtggcg                        1359

 
<210> 40
<211> 453
<212> PRT
<213> Artificial Sequence
 
<220>
<223> variant of transaminase from Vibrio fluvialis Js17
 
<400> 40
Met Asn Lys Pro Gln Ser Trp Glu Thr Arg Ala Glu Thr Tyr Ser Leu 
1               5                   10                  15      
Tyr Gly Phe Thr Asp Met Pro Ser Leu His Gln Arg Gly Thr Val Val 
            20                  25                  30          
Val Thr His Gly Glu Gly Pro Tyr Ile Val Asp Val His Gly Arg Arg 
        35                  40                  45              
Tyr Leu Asp Ala Asn Ser Gly Ala Leu Asn Met Val Ala Gly Phe Asp 
    50                  55                  60                  
His Lys Gly Leu Ile Asp Ala Ala Lys Thr Gln Tyr Glu Arg Phe Pro 
65                  70                  75                  80  
Gly Tyr His Ala Val Lys Gly Arg Met Ser Asp Gln Thr Val Met Leu 
                85                  90                  95      
Ser Glu Lys Leu Val Glu Val Ser Pro Phe Asp Ser Gly Arg Val Phe 
            100                 105                 110         
Tyr Thr Asn Ser Gly Ser Glu Ala Asn Asp Thr Met Val Lys Met Leu 
        115                 120                 125             
Trp Phe Leu His Ala Ala Glu Gly Lys Pro Gln Lys Arg Lys Ile Leu 
    130                 135                 140                 
Thr Arg Trp Asn Ala Tyr His Gly Ala Thr Ala Val Ser Ala Ser Met 
145                 150                 155                 160 
Thr Gly Phe Pro Tyr Asn Ser Val Phe Gly Leu Pro Leu Pro Gly Phe 
                165                 170                 175     
Leu His Leu Thr Cys Pro His Tyr Trp Arg Tyr Gly Glu Glu Gly Glu 
            180                 185                 190         
Thr Glu Glu Gln Phe Val Ala Arg Leu Ala His Glu Leu Glu Glu Thr 
        195                 200                 205             
Ile Gln Lys Glu Gly Ala Asp Thr Ile Ala Gly Phe Phe Ala Glu Pro 
    210                 215                 220                 
Val Met Gly Ala Gly Gly Val Ile Pro Pro Ala Lys Gly Tyr Phe Gln 
225                 230                 235                 240 
Ala Ile Leu Pro Ile Leu Arg Lys Tyr Asp Ile Pro Val Ile Ser Asp 
                245                 250                 255     
Glu Val Ile Cys Gly Phe Gly Arg Thr Gly Asn Thr Trp Gly Cys Val 
            260                 265                 270         
Thr Tyr Asp Phe Thr Pro Asp Ala Ile Ile Ser Ser Lys Ser Leu Thr 
        275                 280                 285             
Ala Gly Phe Phe Pro Val Gly Ala Val Ile Leu Gly Pro Glu Leu Ser 
    290                 295                 300                 
Lys Arg Leu Glu Thr Ala Ile Glu Ala Arg Glu Trp Phe Pro His Gly 
305                 310                 315                 320 
Phe Thr Thr Gly Gly His Pro Val Gly Cys Ala Ile Ala Leu Lys Ala 
                325                 330                 335     
Ile Asp Val Val Met Asn Glu Gly Leu Ala Glu Asn Val Arg Arg Leu 
            340                 345                 350         
Ala Pro Arg Phe Glu Glu Arg Leu Lys His Ile Ala Glu Arg Pro Asn 
        355                 360                 365             
Ile Gly Glu Tyr Arg Gly Ile Gly Phe Met Trp Ala Leu Glu Val Val 
    370                 375                 380                 
Lys Asp Lys Ala Ser Lys Ala Pro Phe Gly Gly Asn Leu Ser Val Ser 
385                 390                 395                 400 
Glu Arg Ile Ala Asn Thr Cys Thr Asp Leu Gly Leu Ile Val Arg Ala 
                405                 410                 415     
Leu Gly Gln Ser Val Ala Leu Cys Pro Pro Phe Ile Leu Thr Glu Ala 
            420                 425                 430         
Gln Met Asp Glu Met Phe Asp Lys Leu Glu Lys Ala Leu Asp Lys Val 
        435                 440                 445             
Phe Ala Glu Val Ala                                             
    450                                                         

 
<210> 41
<211> 1359
<212> DNA
<213> Artificial Sequence
 
<220>
<223> variant of transaminase from Vibrio fluvialis Js17
 
<400> 41
atgaacaaac cgcagagctg ggaaacgcgt gcggaaacct atagcctgta tggttttacc 60
gatatgccga gcctgcatca gcgtggcacc gtggtggtga cccatggcga aggcccgtat 120
atcgtggatg tgcatggccg tcgttatctg gatgcgaaca gcggcgctct gaacatggtg 180
gcgggctttg atcataaagg cctgattgat gcggcgaaaa cgcagtatga acgttttccg 240
ggctatcatg cggttgcggg ccgtatgagc gatcagaccg tgatgctgtc tgaaaaactg 300
gtggaagtga gcccgtttga tagcggccgt gtgttttata ccaacagcgg cagcgaagcg 360
tgcgatacca tggtgaaaat gctgtggttt ctgcatgcgg cggaaggcaa accgcagaaa 420
cgtaaaattc tgacccgttg gaacgcgtat catggcgcga ccgcggtgag cgcgagcatg 480
accggctttc cgtataacag cgtgtttggc ctgccgctgc cgggctttct gcatctgacc 540
tgcccgcatt attggcgtta tggcgaagaa ggcgaaaccg aagaacagtt tgtcgcgcgt 600
ctggcccatg aactggaaga aaccattcag aaggaaggcg cggataccat tgcgggcttt 660
tttgcggaac cggtgatggg tgcgggcggt gttattccgc cggcaaaagg ctattttcag 720
gcgattctgc cgatcctgcg caaatatgat attccggtga tcagcgatga agtgatttgc 780
ggcttcggcc gtaccggtaa cacctggggc tgcgtgacct atgattttac cccggatgcg 840
attattagca gtaaaagcct aaccgcgggt ttttttccgg taggcgcggt gattctgggt 900
ccggaactga gcaaacgtct ggaaaccgcg attgaagcgc gtgaatggtt tccgcatggt 960
tttaccacag gcggccatcc ggtgggttgt gcgaccgcgc tgaaagcgat tgatgtggtg 1020
atgaacgaag gcctggccga aaacgtgcgt cgtctggccc cgcgttttga agaacgtctg 1080
aaacatattg cggaacgtcc gaacattggc gaatatcgtg gcattggctt tatgtgggcg 1140
ctggaagtcg tgaaagataa agcgagcaaa gccccgtttg gtggcaacct gagcgtgagc 1200
gaacgtattg cgaacacctg caccgatctg ggcctgattg tgcgtgcgct gggccagagc 1260
gtggcgctgt gcccgccgtt tattctgacc gaagcgcaga tggatgaaat gttcgataaa 1320
ctggaaaaag cgctggataa agtgttcgcg gaagtggcg                        1359

 
<210> 42
<211> 453
<212> PRT
<213> Artificial Sequence
 
<220>
<223> variant of transaminase from Vibrio fluvialis Js17
 
<400> 42
Met Asn Lys Pro Gln Ser Trp Glu Thr Arg Ala Glu Thr Tyr Ser Leu 
1               5                   10                  15      
Tyr Gly Phe Thr Asp Met Pro Ser Leu His Gln Arg Gly Thr Val Val 
            20                  25                  30          
Val Thr His Gly Glu Gly Pro Tyr Ile Val Asp Val His Gly Arg Arg 
        35                  40                  45              
Tyr Leu Asp Ala Asn Ser Gly Ala Leu Asn Met Val Ala Gly Phe Asp 
    50                  55                  60                  
His Lys Gly Leu Ile Asp Ala Ala Lys Thr Gln Tyr Glu Arg Phe Pro 
65                  70                  75                  80  
Gly Tyr His Ala Val Ala Gly Arg Met Ser Asp Gln Thr Val Met Leu 
                85                  90                  95      
Ser Glu Lys Leu Val Glu Val Ser Pro Phe Asp Ser Gly Arg Val Phe 
            100                 105                 110         
Tyr Thr Asn Ser Gly Ser Glu Ala Cys Asp Thr Met Val Lys Met Leu 
        115                 120                 125             
Trp Phe Leu His Ala Ala Glu Gly Lys Pro Gln Lys Arg Lys Ile Leu 
    130                 135                 140                 
Thr Arg Trp Asn Ala Tyr His Gly Ala Thr Ala Val Ser Ala Ser Met 
145                 150                 155                 160 
Thr Gly Phe Pro Tyr Asn Ser Val Phe Gly Leu Pro Leu Pro Gly Phe 
                165                 170                 175     
Leu His Leu Thr Cys Pro His Tyr Trp Arg Tyr Gly Glu Glu Gly Glu 
            180                 185                 190         
Thr Glu Glu Gln Phe Val Ala Arg Leu Ala His Glu Leu Glu Glu Thr 
        195                 200                 205             
Ile Gln Lys Glu Gly Ala Asp Thr Ile Ala Gly Phe Phe Ala Glu Pro 
    210                 215                 220                 
Val Met Gly Ala Gly Gly Val Ile Pro Pro Ala Lys Gly Tyr Phe Gln 
225                 230                 235                 240 
Ala Ile Leu Pro Ile Leu Arg Lys Tyr Asp Ile Pro Val Ile Ser Asp 
                245                 250                 255     
Glu Val Ile Cys Gly Phe Gly Arg Thr Gly Asn Thr Trp Gly Cys Val 
            260                 265                 270         
Thr Tyr Asp Phe Thr Pro Asp Ala Ile Ile Ser Ser Lys Ser Leu Thr 
        275                 280                 285             
Ala Gly Phe Phe Pro Val Gly Ala Val Ile Leu Gly Pro Glu Leu Ser 
    290                 295                 300                 
Lys Arg Leu Glu Thr Ala Ile Glu Ala Arg Glu Trp Phe Pro His Gly 
305                 310                 315                 320 
Phe Thr Thr Gly Gly His Pro Val Gly Cys Ala Thr Ala Leu Lys Ala 
                325                 330                 335     
Ile Asp Val Val Met Asn Glu Gly Leu Ala Glu Asn Val Arg Arg Leu 
            340                 345                 350         
Ala Pro Arg Phe Glu Glu Arg Leu Lys His Ile Ala Glu Arg Pro Asn 
        355                 360                 365             
Ile Gly Glu Tyr Arg Gly Ile Gly Phe Met Trp Ala Leu Glu Val Val 
    370                 375                 380                 
Lys Asp Lys Ala Ser Lys Ala Pro Phe Gly Gly Asn Leu Ser Val Ser 
385                 390                 395                 400 
Glu Arg Ile Ala Asn Thr Cys Thr Asp Leu Gly Leu Ile Val Arg Ala 
                405                 410                 415     
Leu Gly Gln Ser Val Ala Leu Cys Pro Pro Phe Ile Leu Thr Glu Ala 
            420                 425                 430         
Gln Met Asp Glu Met Phe Asp Lys Leu Glu Lys Ala Leu Asp Lys Val 
        435                 440                 445             
Phe Ala Glu Val Ala                                             
    450                                                         

 
<210> 43
<211> 1359
<212> DNA
<213> Artificial Sequence
 
<220>
<223> variant of transaminase from Vibrio fluvialis Js17
 
<400> 43
atgaacaaac cgcagagctg ggaaacgcgt gcggaaacct atagcctgta tggttttacc 60
gatatgccga gcctgcatca gcgtggcacc gtggtggtga cccatggcga aggcccgtat 120
atcgtggatg tgcatggccg tcgttatctg gatgcgaaca gcggcgctgc gaacatggtg 180
gcgggctttg atcataaagg cctgattgat gcggcgaaaa cgcagtatga acgttttccg 240
ggctatcatg cggttaaagg ccgtatgagc gatcagaccg tgatgctgtc tgaaaaactg 300
gtggaagtga gcccgtttga tagcggccgt gtgttttata ccaacagcgg cagcgaagcg 360
aacgatacca tggtgaaaat gctgtggttt ctgcatgcgg cggaaggcaa accgcagaaa 420
cgtaaaattc tgacccgttg gaacgcgtat catggcgcga ccgcggtggg cgcgagcatg 480
accggctttc cgtataacag cgtgtttggc ctgccgctgc cgggctttct gcatctgacc 540
tgcccgcatt attggcgtta tggcgaagaa ggcgaaaccg aagaacagtt tgtcgcgcgt 600
ctggcccatg aactggaaga aaccattcag aaggaaggcg cggataccat tgcgggcttt 660
tttgcggaac cggtgatggg tgcgggcggt gttattccgc cggcaaaagg ctattttcag 720
gcgattctgc cgatcctgcg caaatatgat attccggtga tcagcgatga agtggtgtgc 780
ggcttcggcc gtaccggtaa cacctggggc tgcgtgacct atgattttac cccggatgcg 840
attattagca gtaaaagcct aaccgcgggt ttttttccgg taggcgcggt gattctgggt 900
ccggaactga gcaaacgtct ggaaaccgcg attgaagcgc gtgaatggtt tccgcatggt 960
tttaccacag gcggccatcc ggtgggttgt gcgattgcgc tgaaagcgat tgatgtggtg 1020
atgaacgaag gcctggccga aaacgtgcgt cgtctggccc cgcgttttga agaacgtctg 1080
aaacatattg cggaacgtcc gaacattggc gaatatcgtg gcattggctt tatgtgggcg 1140
ctggaagtcg tgaaagataa agcgagcaaa gccccgtttg gtggcaacct gagcgtgagc 1200
gaacgtattg cgaacacctg caccgatctg ggcctgattg tgcgtgcgct gggccagagc 1260
gtggcgctgt gcccgccgtt tattctgacc gaagcgcaga tggatgaaat gttcgataaa 1320
ctggaaaaag cgctggataa agtgttcgcg gaagtggcg                        1359

 
<210> 44
<211> 453
<212> PRT
<213> Artificial Sequence
 
<220>
<223> variant of transaminase from Vibrio fluvialis Js17
 
<400> 44
Met Asn Lys Pro Gln Ser Trp Glu Thr Arg Ala Glu Thr Tyr Ser Leu 
1               5                   10                  15      
Tyr Gly Phe Thr Asp Met Pro Ser Leu His Gln Arg Gly Thr Val Val 
            20                  25                  30          
Val Thr His Gly Glu Gly Pro Tyr Ile Val Asp Val His Gly Arg Arg 
        35                  40                  45              
Tyr Leu Asp Ala Asn Ser Gly Ala Ala Asn Met Val Ala Gly Phe Asp 
    50                  55                  60                  
His Lys Gly Leu Ile Asp Ala Ala Lys Thr Gln Tyr Glu Arg Phe Pro 
65                  70                  75                  80  
Gly Tyr His Ala Val Lys Gly Arg Met Ser Asp Gln Thr Val Met Leu 
                85                  90                  95      
Ser Glu Lys Leu Val Glu Val Ser Pro Phe Asp Ser Gly Arg Val Phe 
            100                 105                 110         
Tyr Thr Asn Ser Gly Ser Glu Ala Asn Asp Thr Met Val Lys Met Leu 
        115                 120                 125             
Trp Phe Leu His Ala Ala Glu Gly Lys Pro Gln Lys Arg Lys Ile Leu 
    130                 135                 140                 
Thr Arg Trp Asn Ala Tyr His Gly Ala Thr Ala Val Gly Ala Ser Met 
145                 150                 155                 160 
Thr Gly Phe Pro Tyr Asn Ser Val Phe Gly Leu Pro Leu Pro Gly Phe 
                165                 170                 175     
Leu His Leu Thr Cys Pro His Tyr Trp Arg Tyr Gly Glu Glu Gly Glu 
            180                 185                 190         
Thr Glu Glu Gln Phe Val Ala Arg Leu Ala His Glu Leu Glu Glu Thr 
        195                 200                 205             
Ile Gln Lys Glu Gly Ala Asp Thr Ile Ala Gly Phe Phe Ala Glu Pro 
    210                 215                 220                 
Val Met Gly Ala Gly Gly Val Ile Pro Pro Ala Lys Gly Tyr Phe Gln 
225                 230                 235                 240 
Ala Ile Leu Pro Ile Leu Arg Lys Tyr Asp Ile Pro Val Ile Ser Asp 
                245                 250                 255     
Glu Val Val Cys Gly Phe Gly Arg Thr Gly Asn Thr Trp Gly Cys Val 
            260                 265                 270         
Thr Tyr Asp Phe Thr Pro Asp Ala Ile Ile Ser Ser Lys Ser Leu Thr 
        275                 280                 285             
Ala Gly Phe Phe Pro Val Gly Ala Val Ile Leu Gly Pro Glu Leu Ser 
    290                 295                 300                 
Lys Arg Leu Glu Thr Ala Ile Glu Ala Arg Glu Trp Phe Pro His Gly 
305                 310                 315                 320 
Phe Thr Thr Gly Gly His Pro Val Gly Cys Ala Ile Ala Leu Lys Ala 
                325                 330                 335     
Ile Asp Val Val Met Asn Glu Gly Leu Ala Glu Asn Val Arg Arg Leu 
            340                 345                 350         
Ala Pro Arg Phe Glu Glu Arg Leu Lys His Ile Ala Glu Arg Pro Asn 
        355                 360                 365             
Ile Gly Glu Tyr Arg Gly Ile Gly Phe Met Trp Ala Leu Glu Val Val 
    370                 375                 380                 
Lys Asp Lys Ala Ser Lys Ala Pro Phe Gly Gly Asn Leu Ser Val Ser 
385                 390                 395                 400 
Glu Arg Ile Ala Asn Thr Cys Thr Asp Leu Gly Leu Ile Val Arg Ala 
                405                 410                 415     
Leu Gly Gln Ser Val Ala Leu Cys Pro Pro Phe Ile Leu Thr Glu Ala 
            420                 425                 430         
Gln Met Asp Glu Met Phe Asp Lys Leu Glu Lys Ala Leu Asp Lys Val 
        435                 440                 445             
Phe Ala Glu Val Ala                                             
    450                                                         

 
<210> 45
<211> 1359
<212> DNA
<213> Artificial Sequence
 
<220>
<223> variant of transaminase from Vibrio fluvialis Js17
 
<400> 45
atgaacaaac cgcagagctg ggaaacgcgt gcggaaacct atagcctgta tggttttacc 60
gatatgccga gcctgcatca gcgtggcacc gtggtggtga cccatggcga aggcccgtat 120
atcgtggatg tgcatggccg tcgttatctg gatgcgaaca gcggcgctgc gaacatggtg 180
gcgggctttg atcataaagg cctgattgat gcggcgaaaa cgcagtatga acgttttccg 240
ggctatcatg cggttaaagg ccgtatgagc gatcagaccg tgatgctgtc tgaaaaactg 300
gtggaagtga gcccgtttga tagcggccgt gtgttttata ccaacagcgg cagcgaagcg 360
gcggatacca tggtgaaaat gctgtggttt ctgcatgcgg cggaaggcaa accgcagaaa 420
cgtaaaattc tgacccgttg gaacgcgtat catggcgcga ccgcggtgag cgcgagcatg 480
accggctttc cgtataacag cgtgtttggc ctgccgctgc cgggctttct gcatctgacc 540
tgcccgcatt attggcgtta tggcgaagaa ggcgaaaccg aagaacagtt tgtcgcgcgt 600
ctggcccatg aactggaaga aaccattcag aaggaaggcg cggataccat tgcgggcttt 660
tttgcggaac cggtgatggg tgcgggcggt gttattccgc cggcaaaagg ctattttcag 720
gcgattctgc cgatcctgcg caaatatgat attccggtga tcagcgatga agtgatttgc 780
ggcttcggcc gtaccggtaa cacctggggc tgcgtgacct atgattttac cccggatgcg 840
attattagca gtaaaagcct aaccgcgggt ttttttccgg taggcgcggt gattctgggt 900
ccggaactga gcaaacgtct ggaaaccgcg attgaagcgc gtgaatggtt tccgcatggt 960
tttaccacag gcggccatcc ggtgggttgt gcgaccgcgc tgaaagcgat tgatgtggtg 1020
atgaacgaag gcctggccga aaacgtgcgt cgtctggccc cgcgttttga agaacgtctg 1080
aaacatattg cggaacgtcc gaacattggc gaatatcgtg gcattggctt tatgtgggcg 1140
ctggaagtcg tgaaagataa agcgagcaaa gccccgtttg gtggcaacct gagcgtgagc 1200
gaacgtattg cgaacacctg caccgatctg ggcctgattg tgcgtgcgct gggccagagc 1260
gtggcgctgt gcccgccgtt tattctgacc gaagcgcaga tggatgaaat gttcgataaa 1320
ctggaaaaag cgctggataa agtgttcgcg gaagtggcg                        1359

 
<210> 46
<211> 453
<212> PRT
<213> Artificial Sequence
 
<220>
<223> variant of transaminase from Vibrio fluvialis Js17
 
<400> 46
Met Asn Lys Pro Gln Ser Trp Glu Thr Arg Ala Glu Thr Tyr Ser Leu 
1               5                   10                  15      
Tyr Gly Phe Thr Asp Met Pro Ser Leu His Gln Arg Gly Thr Val Val 
            20                  25                  30          
Val Thr His Gly Glu Gly Pro Tyr Ile Val Asp Val His Gly Arg Arg 
        35                  40                  45              
Tyr Leu Asp Ala Asn Ser Gly Ala Ala Asn Met Val Ala Gly Phe Asp 
    50                  55                  60                  
His Lys Gly Leu Ile Asp Ala Ala Lys Thr Gln Tyr Glu Arg Phe Pro 
65                  70                  75                  80  
Gly Tyr His Ala Val Lys Gly Arg Met Ser Asp Gln Thr Val Met Leu 
                85                  90                  95      
Ser Glu Lys Leu Val Glu Val Ser Pro Phe Asp Ser Gly Arg Val Phe 
            100                 105                 110         
Tyr Thr Asn Ser Gly Ser Glu Ala Ala Asp Thr Met Val Lys Met Leu 
        115                 120                 125             
Trp Phe Leu His Ala Ala Glu Gly Lys Pro Gln Lys Arg Lys Ile Leu 
    130                 135                 140                 
Thr Arg Trp Asn Ala Tyr His Gly Ala Thr Ala Val Ser Ala Ser Met 
145                 150                 155                 160 
Thr Gly Phe Pro Tyr Asn Ser Val Phe Gly Leu Pro Leu Pro Gly Phe 
                165                 170                 175     
Leu His Leu Thr Cys Pro His Tyr Trp Arg Tyr Gly Glu Glu Gly Glu 
            180                 185                 190         
Thr Glu Glu Gln Phe Val Ala Arg Leu Ala His Glu Leu Glu Glu Thr 
        195                 200                 205             
Ile Gln Lys Glu Gly Ala Asp Thr Ile Ala Gly Phe Phe Ala Glu Pro 
    210                 215                 220                 
Val Met Gly Ala Gly Gly Val Ile Pro Pro Ala Lys Gly Tyr Phe Gln 
225                 230                 235                 240 
Ala Ile Leu Pro Ile Leu Arg Lys Tyr Asp Ile Pro Val Ile Ser Asp 
                245                 250                 255     
Glu Val Ile Cys Gly Phe Gly Arg Thr Gly Asn Thr Trp Gly Cys Val 
            260                 265                 270         
Thr Tyr Asp Phe Thr Pro Asp Ala Ile Ile Ser Ser Lys Ser Leu Thr 
        275                 280                 285             
Ala Gly Phe Phe Pro Val Gly Ala Val Ile Leu Gly Pro Glu Leu Ser 
    290                 295                 300                 
Lys Arg Leu Glu Thr Ala Ile Glu Ala Arg Glu Trp Phe Pro His Gly 
305                 310                 315                 320 
Phe Thr Thr Gly Gly His Pro Val Gly Cys Ala Thr Ala Leu Lys Ala 
                325                 330                 335     
Ile Asp Val Val Met Asn Glu Gly Leu Ala Glu Asn Val Arg Arg Leu 
            340                 345                 350         
Ala Pro Arg Phe Glu Glu Arg Leu Lys His Ile Ala Glu Arg Pro Asn 
        355                 360                 365             
Ile Gly Glu Tyr Arg Gly Ile Gly Phe Met Trp Ala Leu Glu Val Val 
    370                 375                 380                 
Lys Asp Lys Ala Ser Lys Ala Pro Phe Gly Gly Asn Leu Ser Val Ser 
385                 390                 395                 400 
Glu Arg Ile Ala Asn Thr Cys Thr Asp Leu Gly Leu Ile Val Arg Ala 
                405                 410                 415     
Leu Gly Gln Ser Val Ala Leu Cys Pro Pro Phe Ile Leu Thr Glu Ala 
            420                 425                 430         
Gln Met Asp Glu Met Phe Asp Lys Leu Glu Lys Ala Leu Asp Lys Val 
        435                 440                 445             
Phe Ala Glu Val Ala                                             
    450                                                         

 
<210> 47
<211> 1359
<212> DNA
<213> Artificial Sequence
 
<220>
<223> variant of transaminase from Vibrio fluvialis Js17
 
<400> 47
atgaacaaac cgcagagctg ggaaacgcgt gcggaaacct atagcctgta tggttttacc 60
gatatgccga gcctgcatca gcgtggcacc gtggtggtga cccatggcga aggcccgtat 120
atcgtggatg tgcatggccg tcgttatctg gatgcgaaca gcggcgctgc gaacatggtg 180
gcgggctttg atcataaagg cctgattgat gcggcgaaaa cgcagtatga acgttttccg 240
ggctatcatg cggttaaagg ccgtatgagc gatcagaccg tgatgctgtc tgaaaaactg 300
gtggaagtga gcccgtttga tagcggccgt gtgttttata ccaacagcgg cagcgaagcg 360
aacgatacca tggtgaaaat gctgtggttt ctgcatgcgg cggaaggcaa accgcagaaa 420
cgtaaaattc tgacccgttg gaacgcgtat catggcgcga ccgcggtgag cgcgagcatg 480
accggctttc cgtataacag cgtgtttggc ctgccgctgc cgggctttct gcatctgacc 540
tgcccgcatt attggcgtta tggcgaagaa ggcgaaaccg aagaacagtt tgtcgcgcgt 600
ctggcccatg aactggaaga aaccattcag aaggaaggcg cggataccat tgcgggcttt 660
tttgcggaac cggtgatggg tgcgggcggt gttattccgc cggcaaaagg ctattttcag 720
gcgattctgc cgatcctgcg caaatatgat attccggtga tcagcgatga agtgatttgc 780
ggcttcggcc gtaccggtaa cacctggggc tgcgtgacct atgattttac cccggatgcg 840
attattagca gtaaaagcct aaccgcgggt ttttttccgg taggcgcggt gattctgggt 900
ccggaactga gcaaacgtct ggaaaccgcg attgaagcgc gtgaatggtt tccgcatggt 960
tttaccacag gcggccatcc ggtgggttgt gcgattgcgc tgaaagcgat tgatgtggtg 1020
atgaacgaag gcctggccga aaacgtgcgt cgtctggccc cgcgttttga agaacgtctg 1080
aaacatattg cggaacgtcc gaacattggc gaatatcgtg gcattggctt tatgtgggcg 1140
ctggaagtcg tgaaagataa agcgagcaaa gccccgtttg gtggcaacct gagcgtgagc 1200
gaacgtattg cgaacacctg caccgatctg ggcctgattg tgcgtgcgct gggccagagc 1260
gtggcgctgt gcccgccgtt tattctgacc gaagcgcaga tggatgaaat gttcgataaa 1320
ctggaaaaag cgctggataa agtgttcgcg gaagtggcg                        1359

 
<210> 48
<211> 453
<212> PRT
<213> Artificial Sequence
 
<220>
<223> variant of transaminase from Vibrio fluvialis Js17
 
<400> 48
Met Asn Lys Pro Gln Ser Trp Glu Thr Arg Ala Glu Thr Tyr Ser Leu 
1               5                   10                  15      
Tyr Gly Phe Thr Asp Met Pro Ser Leu His Gln Arg Gly Thr Val Val 
            20                  25                  30          
Val Thr His Gly Glu Gly Pro Tyr Ile Val Asp Val His Gly Arg Arg 
        35                  40                  45              
Tyr Leu Asp Ala Asn Ser Gly Ala Ala Asn Met Val Ala Gly Phe Asp 
    50                  55                  60                  
His Lys Gly Leu Ile Asp Ala Ala Lys Thr Gln Tyr Glu Arg Phe Pro 
65                  70                  75                  80  
Gly Tyr His Ala Val Lys Gly Arg Met Ser Asp Gln Thr Val Met Leu 
                85                  90                  95      
Ser Glu Lys Leu Val Glu Val Ser Pro Phe Asp Ser Gly Arg Val Phe 
            100                 105                 110         
Tyr Thr Asn Ser Gly Ser Glu Ala Asn Asp Thr Met Val Lys Met Leu 
        115                 120                 125             
Trp Phe Leu His Ala Ala Glu Gly Lys Pro Gln Lys Arg Lys Ile Leu 
    130                 135                 140                 
Thr Arg Trp Asn Ala Tyr His Gly Ala Thr Ala Val Ser Ala Ser Met 
145                 150                 155                 160 
Thr Gly Phe Pro Tyr Asn Ser Val Phe Gly Leu Pro Leu Pro Gly Phe 
                165                 170                 175     
Leu His Leu Thr Cys Pro His Tyr Trp Arg Tyr Gly Glu Glu Gly Glu 
            180                 185                 190         
Thr Glu Glu Gln Phe Val Ala Arg Leu Ala His Glu Leu Glu Glu Thr 
        195                 200                 205             
Ile Gln Lys Glu Gly Ala Asp Thr Ile Ala Gly Phe Phe Ala Glu Pro 
    210                 215                 220                 
Val Met Gly Ala Gly Gly Val Ile Pro Pro Ala Lys Gly Tyr Phe Gln 
225                 230                 235                 240 
Ala Ile Leu Pro Ile Leu Arg Lys Tyr Asp Ile Pro Val Ile Ser Asp 
                245                 250                 255     
Glu Val Ile Cys Gly Phe Gly Arg Thr Gly Asn Thr Trp Gly Cys Val 
            260                 265                 270         
Thr Tyr Asp Phe Thr Pro Asp Ala Ile Ile Ser Ser Lys Ser Leu Thr 
        275                 280                 285             
Ala Gly Phe Phe Pro Val Gly Ala Val Ile Leu Gly Pro Glu Leu Ser 
    290                 295                 300                 
Lys Arg Leu Glu Thr Ala Ile Glu Ala Arg Glu Trp Phe Pro His Gly 
305                 310                 315                 320 
Phe Thr Thr Gly Gly His Pro Val Gly Cys Ala Ile Ala Leu Lys Ala 
                325                 330                 335     
Ile Asp Val Val Met Asn Glu Gly Leu Ala Glu Asn Val Arg Arg Leu 
            340                 345                 350         
Ala Pro Arg Phe Glu Glu Arg Leu Lys His Ile Ala Glu Arg Pro Asn 
        355                 360                 365             
Ile Gly Glu Tyr Arg Gly Ile Gly Phe Met Trp Ala Leu Glu Val Val 
    370                 375                 380                 
Lys Asp Lys Ala Ser Lys Ala Pro Phe Gly Gly Asn Leu Ser Val Ser 
385                 390                 395                 400 
Glu Arg Ile Ala Asn Thr Cys Thr Asp Leu Gly Leu Ile Val Arg Ala 
                405                 410                 415     
Leu Gly Gln Ser Val Ala Leu Cys Pro Pro Phe Ile Leu Thr Glu Ala 
            420                 425                 430         
Gln Met Asp Glu Met Phe Asp Lys Leu Glu Lys Ala Leu Asp Lys Val 
        435                 440                 445             
Phe Ala Glu Val Ala                                             
    450                                                         

 
<210> 49
<211> 1359
<212> DNA
<213> Artificial Sequence
 
<220>
<223> variant of transaminase from Vibrio fluvialis Js17
 
<400> 49
atgaacaaac cgcagagctg ggaaacgcgt gcggaaacct atagcctgta tggttttacc 60
gatatgccga gcctgcatca gcgtggcacc gtggtggtga cccatggcga aggcccgtat 120
atcgtggatg tgcatggccg tcgttatctg gatgcgaaca gcggcgctct gaacatggtg 180
gcgggctttg atcataaagg cctgattgat gcggcgaaaa cgcagtatga acgttttccg 240
ggctatcatg cggttgcggg ccgtatgagc gatcagaccg tgatgctgtc tgaaaaactg 300
gtggaagtga gcccgtttga tagcggccgt gtgttttata ccaacagcgg cagcgaagcg 360
gcggatacca tggtgaaaat gctgtggttt ctgcatgcgg cggaaggcaa accgcagaaa 420
cgtaaaattc tgacccgttg gaacgcgtat catggcgcga ccgcggtgag cgcgagcatg 480
accggctttc cgtataacag cgtgtttggc ctgccgctgc cgggctttct gcatctgacc 540
tgcccgcatt attggcgtta tggcgaagaa ggcgaaaccg aagaacagtt tgtcgcgcgt 600
ctggcccatg aactggaaga aaccattcag aaggaaggcg cggataccat tgcgggcttt 660
tttgcggaac cggtgatggg tgcgggcggt gttattccgc cggcaaaagg ctattttcag 720
gcgattctgc cgatcctgcg caaatatgat attccggtga tcagcgatga agtgatttgc 780
ggcttcggcc gtaccggtaa cacctggggc tgcgtgacct atgattttac cccggatgcg 840
attattagca gtaaaagcct aaccgcgggt ttttttccgg taggcgcggt gattctgggt 900
ccggaactga gcaaacgtct ggaaaccgcg attgaagcgc gtgaatggtt tccgcatggt 960
tttaccacag gcggccatcc ggtgggttgt gcgattgcgc tgaaagcgat tgatgtggtg 1020
atgaacgaag gcctggccga aaacgtgcgt cgtctggccc cgcgttttga agaacgtctg 1080
aaacatattg cggaacgtcc gaacattggc gaatatcgtg gcattggctt tatgtgggcg 1140
ctggaagtcg tgaaagataa agcgagcaaa gccccgtttg gtggcaacct gagcgtgagc 1200
gaacgtattg cgaacacctg caccgatctg ggcctgattg tgcgtgcgct gggccagagc 1260
gtggcgctgt gcccgccgtt tattctgacc gaagcgcaga tggatgaaat gttcgataaa 1320
ctggaaaaag cgctggataa agtgttcgcg gaagtggcg                        1359

 
<210> 50
<211> 453
<212> PRT
<213> Artificial Sequence
 
<220>
<223> variant of transaminase from Vibrio fluvialis Js17
 
<400> 50
Met Asn Lys Pro Gln Ser Trp Glu Thr Arg Ala Glu Thr Tyr Ser Leu 
1               5                   10                  15      
Tyr Gly Phe Thr Asp Met Pro Ser Leu His Gln Arg Gly Thr Val Val 
            20                  25                  30          
Val Thr His Gly Glu Gly Pro Tyr Ile Val Asp Val His Gly Arg Arg 
        35                  40                  45              
Tyr Leu Asp Ala Asn Ser Gly Ala Leu Asn Met Val Ala Gly Phe Asp 
    50                  55                  60                  
His Lys Gly Leu Ile Asp Ala Ala Lys Thr Gln Tyr Glu Arg Phe Pro 
65                  70                  75                  80  
Gly Tyr His Ala Val Ala Gly Arg Met Ser Asp Gln Thr Val Met Leu 
                85                  90                  95      
Ser Glu Lys Leu Val Glu Val Ser Pro Phe Asp Ser Gly Arg Val Phe 
            100                 105                 110         
Tyr Thr Asn Ser Gly Ser Glu Ala Ala Asp Thr Met Val Lys Met Leu 
        115                 120                 125             
Trp Phe Leu His Ala Ala Glu Gly Lys Pro Gln Lys Arg Lys Ile Leu 
    130                 135                 140                 
Thr Arg Trp Asn Ala Tyr His Gly Ala Thr Ala Val Ser Ala Ser Met 
145                 150                 155                 160 
Thr Gly Phe Pro Tyr Asn Ser Val Phe Gly Leu Pro Leu Pro Gly Phe 
                165                 170                 175     
Leu His Leu Thr Cys Pro His Tyr Trp Arg Tyr Gly Glu Glu Gly Glu 
            180                 185                 190         
Thr Glu Glu Gln Phe Val Ala Arg Leu Ala His Glu Leu Glu Glu Thr 
        195                 200                 205             
Ile Gln Lys Glu Gly Ala Asp Thr Ile Ala Gly Phe Phe Ala Glu Pro 
    210                 215                 220                 
Val Met Gly Ala Gly Gly Val Ile Pro Pro Ala Lys Gly Tyr Phe Gln 
225                 230                 235                 240 
Ala Ile Leu Pro Ile Leu Arg Lys Tyr Asp Ile Pro Val Ile Ser Asp 
                245                 250                 255     
Glu Val Ile Cys Gly Phe Gly Arg Thr Gly Asn Thr Trp Gly Cys Val 
            260                 265                 270         
Thr Tyr Asp Phe Thr Pro Asp Ala Ile Ile Ser Ser Lys Ser Leu Thr 
        275                 280                 285             
Ala Gly Phe Phe Pro Val Gly Ala Val Ile Leu Gly Pro Glu Leu Ser 
    290                 295                 300                 
Lys Arg Leu Glu Thr Ala Ile Glu Ala Arg Glu Trp Phe Pro His Gly 
305                 310                 315                 320 
Phe Thr Thr Gly Gly His Pro Val Gly Cys Ala Ile Ala Leu Lys Ala 
                325                 330                 335     
Ile Asp Val Val Met Asn Glu Gly Leu Ala Glu Asn Val Arg Arg Leu 
            340                 345                 350         
Ala Pro Arg Phe Glu Glu Arg Leu Lys His Ile Ala Glu Arg Pro Asn 
        355                 360                 365             
Ile Gly Glu Tyr Arg Gly Ile Gly Phe Met Trp Ala Leu Glu Val Val 
    370                 375                 380                 
Lys Asp Lys Ala Ser Lys Ala Pro Phe Gly Gly Asn Leu Ser Val Ser 
385                 390                 395                 400 
Glu Arg Ile Ala Asn Thr Cys Thr Asp Leu Gly Leu Ile Val Arg Ala 
                405                 410                 415     
Leu Gly Gln Ser Val Ala Leu Cys Pro Pro Phe Ile Leu Thr Glu Ala 
            420                 425                 430         
Gln Met Asp Glu Met Phe Asp Lys Leu Glu Lys Ala Leu Asp Lys Val 
        435                 440                 445             
Phe Ala Glu Val Ala                                             
    450                                                         

 
<210> 51
<211> 1359
<212> DNA
<213> Artificial Sequence
 
<220>
<223> variant of transaminase from Vibrio fluvialis Js17
 
<400> 51
atgaacaaac cgcagagctg ggaaacgcgt gcggaaacct atagcctgta tggttttacc 60
gatatgagca gcctgcatca gcgtggcacc gtggtggtga cccatggcga aggcccgtat 120
atcgtggatg tgcatggccg tcgttatctg gatgcgtgca gcggcgctct gaacatggtg 180
gcgggctttg atcataaagg cctgattgat gcggcgaaaa cgcagtatga acgttttccg 240
ggctatcatg cggttgcggg ccgtatgagc gatcagaccg tgatgctgtc tgaaaaactg 300
gtggaagtga gcccgtttga tagcggccgt gtgttttata ccaacagcgg cagcgaagcg 360
aacgatacca tggtgaaaat gctgtggttt ctgcatgcgg cggaaggcaa accgcagaaa 420
cgtaaaattc tgacccattg gaacgcgtat catggcgcga ccgcggtgag cgcgagcatg 480
accgattttc cgtataacag cgtgtttggc ctgccgctgc cgggctttct gcatctgacc 540
tgcccgcatt attggcgtta tggcgaagaa ggcgaaaccg aagaacagtt tgtcgcgcgt 600
ctggcccatg aactggaaga aaccattcag aaggaaggcg cggataccat tgcgggcttt 660
tttgcggaac cggtgatggg tgcgggcggt gttattccgc cggcaaaagg ctattttcag 720
gcgattctgc cgatcctgcg caaatatgat attccggtga tcagcgatga agtgatttgc 780
ggcttcggcc gtaccggtaa cacctggggc tgcgtgacct atgattttac cccggatgcg 840
attattagca gtaaaagcct aaccgcgggt ttttttccgg taggcgcggt gattctgggt 900
ccggaactga gcaaacgtct ggaaaccgcg attgaagcgc gtgaatggtt tccgcatggt 960
tttaccacag gcggccatcc ggtgggttgt gcgattgcgc tgaaagcgat tgatgtggtg 1020
atgaacgaag gcctggccga aaacgtgcgt cgtctggccc cgcgttttga agaacgtctg 1080
aaacatattg cggaacgtcc gaacattggc gaatatcgtg gcattggctt tatgtgggcg 1140
ctggaagtcg tgaaagataa agcgagcaaa gccccgtttg gtgataacct gagcgtgagc 1200
gaacgtattg cgaacacctg caccgatctg ggcctgattg tgcgtgcgct gggccagagc 1260
gtggcgctgt gcccgccgtt tattctgacc gaagtgcaga tggatgaaat gttcgataaa 1320
ctggaaaaag cgctggataa agtgttcgcg gaagtggcg                        1359

 
<210> 52
<211> 453
<212> PRT
<213> Artificial Sequence
 
<220>
<223> variant of transaminase from Vibrio fluvialis Js17
 
<400> 52
Met Asn Lys Pro Gln Ser Trp Glu Thr Arg Ala Glu Thr Tyr Ser Leu 
1               5                   10                  15      
Tyr Gly Phe Thr Asp Met Ser Ser Leu His Gln Arg Gly Thr Val Val 
            20                  25                  30          
Val Thr His Gly Glu Gly Pro Tyr Ile Val Asp Val His Gly Arg Arg 
        35                  40                  45              
Tyr Leu Asp Ala Cys Ser Gly Ala Leu Asn Met Val Ala Gly Phe Asp 
    50                  55                  60                  
His Lys Gly Leu Ile Asp Ala Ala Lys Thr Gln Tyr Glu Arg Phe Pro 
65                  70                  75                  80  
Gly Tyr His Ala Val Ala Gly Arg Met Ser Asp Gln Thr Val Met Leu 
                85                  90                  95      
Ser Glu Lys Leu Val Glu Val Ser Pro Phe Asp Ser Gly Arg Val Phe 
            100                 105                 110         
Tyr Thr Asn Ser Gly Ser Glu Ala Asn Asp Thr Met Val Lys Met Leu 
        115                 120                 125             
Trp Phe Leu His Ala Ala Glu Gly Lys Pro Gln Lys Arg Lys Ile Leu 
    130                 135                 140                 
Thr His Trp Asn Ala Tyr His Gly Ala Thr Ala Val Ser Ala Ser Met 
145                 150                 155                 160 
Thr Asp Phe Pro Tyr Asn Ser Val Phe Gly Leu Pro Leu Pro Gly Phe 
                165                 170                 175     
Leu His Leu Thr Cys Pro His Tyr Trp Arg Tyr Gly Glu Glu Gly Glu 
            180                 185                 190         
Thr Glu Glu Gln Phe Val Ala Arg Leu Ala His Glu Leu Glu Glu Thr 
        195                 200                 205             
Ile Gln Lys Glu Gly Ala Asp Thr Ile Ala Gly Phe Phe Ala Glu Pro 
    210                 215                 220                 
Val Met Gly Ala Gly Gly Val Ile Pro Pro Ala Lys Gly Tyr Phe Gln 
225                 230                 235                 240 
Ala Ile Leu Pro Ile Leu Arg Lys Tyr Asp Ile Pro Val Ile Ser Asp 
                245                 250                 255     
Glu Val Ile Cys Gly Phe Gly Arg Thr Gly Asn Thr Trp Gly Cys Val 
            260                 265                 270         
Thr Tyr Asp Phe Thr Pro Asp Ala Ile Ile Ser Ser Lys Ser Leu Thr 
        275                 280                 285             
Ala Gly Phe Phe Pro Val Gly Ala Val Ile Leu Gly Pro Glu Leu Ser 
    290                 295                 300                 
Lys Arg Leu Glu Thr Ala Ile Glu Ala Arg Glu Trp Phe Pro His Gly 
305                 310                 315                 320 
Phe Thr Thr Gly Gly His Pro Val Gly Cys Ala Ile Ala Leu Lys Ala 
                325                 330                 335     
Ile Asp Val Val Met Asn Glu Gly Leu Ala Glu Asn Val Arg Arg Leu 
            340                 345                 350         
Ala Pro Arg Phe Glu Glu Arg Leu Lys His Ile Ala Glu Arg Pro Asn 
        355                 360                 365             
Ile Gly Glu Tyr Arg Gly Ile Gly Phe Met Trp Ala Leu Glu Val Val 
    370                 375                 380                 
Lys Asp Lys Ala Ser Lys Ala Pro Phe Gly Asp Asn Leu Ser Val Ser 
385                 390                 395                 400 
Glu Arg Ile Ala Asn Thr Cys Thr Asp Leu Gly Leu Ile Val Arg Ala 
                405                 410                 415     
Leu Gly Gln Ser Val Ala Leu Cys Pro Pro Phe Ile Leu Thr Glu Val 
            420                 425                 430         
Gln Met Asp Glu Met Phe Asp Lys Leu Glu Lys Ala Leu Asp Lys Val 
        435                 440                 445             
Phe Ala Glu Val Ala                                             
    450                                                         

 
<210> 53
<211> 1359
<212> DNA
<213> Artificial Sequence
 
<220>
<223> variant of transaminase from Vibrio fluvialis Js17
 
<400> 53
atgaacaaac cgcagagctg ggaaacgcgt gcggaaacct atagcctgta tggttttacc 60
gatatgagca gcctgcatca gcgtggcacc gtggtggtga cccatggcga aggcccgtat 120
atcgtggatg tgcatggccg tcgttatctg gatgcgtgca gcggcgctct gaacatggtg 180
gcgggctttg atcataaagg cctgattgat gcggcgaaaa cgcagtatga acgttttccg 240
ggctatcatg cggttgcggg ccgtatgagc gatcagaccg tgatgctgtc tgaaaaactg 300
gtggaagtga gcccgtttga tagcggccgt gtgttttata ccaacagcgg cagcgaagcg 360
aacgatacca tggtgaaaat gctgtggttt ctgcatgcgg cggaaggcaa accgcagaaa 420
cgtaaaattc tgacccattg gaacgcgtat catggcgcga ccgcggtgag cgcgagcatg 480
accggcaaac cgtataacag cgtgtttggc ctgccgctgc cgggctttct gcatctgacc 540
tgcccgcatt attggcgtta tggcgaagaa ggcgaaaccg aagaacagtt tgtcgcgcgt 600
ctggcccatg aactggaaga aaccattcag aaggaaggcg cggataccat tgcgggcttt 660
tttgcggaac cggtgatggg tgcgggcggt gttattccgc cggcaaaagg ctattttcag 720
gcgattctgc cgatcctgcg caaatatgat attccggtga tcagcgatga agtgatttgc 780
ggcttcggcc gtaccggtaa cacctggggc tgcgtgacct atgattttac cccggatgcg 840
attattagca gtaaaagcct aaccgcgggt ttttttccgg taggcgcggt gattctgggt 900
ccggaactga gcaaacgtct ggaaaccgcg attgaagcgc gtgaatggtt tccgcatggt 960
tttaccacag gcggccatcc ggtgggttgt gcgattgcgc tgaaagcgat tgatgtggtg 1020
atgaacgaag gcctggccga aaacgtgcgt cgtctggccc cgcgttttga agaacgtctg 1080
aaacatattg cggaacgtcc gaacattggc gaatatcgtg gcattggctt tatgtgggcg 1140
ctggaagtcg tgaaagataa agcgagcaaa gccccgtttg gtggcaacct gagcgtgagc 1200
gaacgtattg cgaacacctg caccgatctg ggcctgattg tgcgtgcgct gggccagagc 1260
gtggcgctgt gcccgccgtt tattctgacc gaagcgcaga tggatgaaat gttcgataaa 1320
ctggaaaaag cgctggataa agtgttcgcg gaagtggcg                        1359

 
<210> 54
<211> 453
<212> PRT
<213> Artificial Sequence
 
<220>
<223> variant of transaminase from Vibrio fluvialis Js17
 
<400> 54
Met Asn Lys Pro Gln Ser Trp Glu Thr Arg Ala Glu Thr Tyr Ser Leu 
1               5                   10                  15      
Tyr Gly Phe Thr Asp Met Ser Ser Leu His Gln Arg Gly Thr Val Val 
            20                  25                  30          
Val Thr His Gly Glu Gly Pro Tyr Ile Val Asp Val His Gly Arg Arg 
        35                  40                  45              
Tyr Leu Asp Ala Cys Ser Gly Ala Leu Asn Met Val Ala Gly Phe Asp 
    50                  55                  60                  
His Lys Gly Leu Ile Asp Ala Ala Lys Thr Gln Tyr Glu Arg Phe Pro 
65                  70                  75                  80  
Gly Tyr His Ala Val Ala Gly Arg Met Ser Asp Gln Thr Val Met Leu 
                85                  90                  95      
Ser Glu Lys Leu Val Glu Val Ser Pro Phe Asp Ser Gly Arg Val Phe 
            100                 105                 110         
Tyr Thr Asn Ser Gly Ser Glu Ala Asn Asp Thr Met Val Lys Met Leu 
        115                 120                 125             
Trp Phe Leu His Ala Ala Glu Gly Lys Pro Gln Lys Arg Lys Ile Leu 
    130                 135                 140                 
Thr His Trp Asn Ala Tyr His Gly Ala Thr Ala Val Ser Ala Ser Met 
145                 150                 155                 160 
Thr Gly Lys Pro Tyr Asn Ser Val Phe Gly Leu Pro Leu Pro Gly Phe 
                165                 170                 175     
Leu His Leu Thr Cys Pro His Tyr Trp Arg Tyr Gly Glu Glu Gly Glu 
            180                 185                 190         
Thr Glu Glu Gln Phe Val Ala Arg Leu Ala His Glu Leu Glu Glu Thr 
        195                 200                 205             
Ile Gln Lys Glu Gly Ala Asp Thr Ile Ala Gly Phe Phe Ala Glu Pro 
    210                 215                 220                 
Val Met Gly Ala Gly Gly Val Ile Pro Pro Ala Lys Gly Tyr Phe Gln 
225                 230                 235                 240 
Ala Ile Leu Pro Ile Leu Arg Lys Tyr Asp Ile Pro Val Ile Ser Asp 
                245                 250                 255     
Glu Val Ile Cys Gly Phe Gly Arg Thr Gly Asn Thr Trp Gly Cys Val 
            260                 265                 270         
Thr Tyr Asp Phe Thr Pro Asp Ala Ile Ile Ser Ser Lys Ser Leu Thr 
        275                 280                 285             
Ala Gly Phe Phe Pro Val Gly Ala Val Ile Leu Gly Pro Glu Leu Ser 
    290                 295                 300                 
Lys Arg Leu Glu Thr Ala Ile Glu Ala Arg Glu Trp Phe Pro His Gly 
305                 310                 315                 320 
Phe Thr Thr Gly Gly His Pro Val Gly Cys Ala Ile Ala Leu Lys Ala 
                325                 330                 335     
Ile Asp Val Val Met Asn Glu Gly Leu Ala Glu Asn Val Arg Arg Leu 
            340                 345                 350         
Ala Pro Arg Phe Glu Glu Arg Leu Lys His Ile Ala Glu Arg Pro Asn 
        355                 360                 365             
Ile Gly Glu Tyr Arg Gly Ile Gly Phe Met Trp Ala Leu Glu Val Val 
    370                 375                 380                 
Lys Asp Lys Ala Ser Lys Ala Pro Phe Gly Gly Asn Leu Ser Val Ser 
385                 390                 395                 400 
Glu Arg Ile Ala Asn Thr Cys Thr Asp Leu Gly Leu Ile Val Arg Ala 
                405                 410                 415     
Leu Gly Gln Ser Val Ala Leu Cys Pro Pro Phe Ile Leu Thr Glu Ala 
            420                 425                 430         
Gln Met Asp Glu Met Phe Asp Lys Leu Glu Lys Ala Leu Asp Lys Val 
        435                 440                 445             
Phe Ala Glu Val Ala                                             
    450                                                         

 
<210> 55
<211> 1359
<212> DNA
<213> Artificial Sequence
 
<220>
<223> variant of transaminase from Vibrio fluvialis Js17
 
<400> 55
atgaacaaac cgcagagctg ggaaacgcgt gcggaaacct atagcctgta tggttttacc 60
gatatgccga gcctgcatca gcgtggcacc gtggtggtga cccatggcga aggcccgtat 120
atcgtggatg tgcatggccg tcgttatctg gatgcgtgca gcggcgctct gaacatggtg 180
gcgggctttg atcataaagg cctgattgat gcggcgaaaa cgcagtatga acgttttccg 240
ggctatcatg cggttgcggg ccgtatgagc gatcagaccg tgatgctgtc tgaaaaactg 300
gtggaagtga gcccgtttga tagcggccgt gtgttttata ccaacagcgg cagcgaagcg 360
aacgatacca tggtgaaaat gctgtggttt ctgcatgcgg cggaaggcaa accgcagaaa 420
cgtaaaattc tgacccattg gaacgcgtat catggcgcga ccgcggtgag cgcgagcatg 480
accgattttc cgtataacag cgtgtttggc ctgccgctgc cgggctttct gcatctgacc 540
tgcccgcatt attggcgtta tggcgaagaa ggcgaaaccg aagaacagtt tgtcgcgcgt 600
ctggcccatg aactggaaga aaccattcag aaggaaggcg cggataccat tgcgggcttt 660
tttgcggaac cggtgatggg tgcgggcggt gttattccgc cggcaaaagg ctattttcag 720
gcgattctgc cgatcctgcg caaatatgat attccggtga tcagcgatga agtgatttgc 780
ggcttcggcc gtaccggtaa cacctggggc tgcgtgacct atgattttac cccggatgcg 840
attattagca gtaaaagcct aaccgcgggt ttttttccgg taggcgcggt gattctgggt 900
ccggaactga gcaaacgtct ggaaaccgcg attgaagcgc gtgaatggtt tccgcatggt 960
tttaccacag gcggccatcc ggtgggttgt gcgattgcgc tgaaagcgat tgatgtggtg 1020
atgaacgaag gcctggccga aaacgtgcgt cgtctggccc cgcgttttga agaacgtctg 1080
aaacatattg cggaacgtcc gaacattggc gaatatcgtg gcattggctt tatgtgggcg 1140
ctggaagtcg tgaaagataa agcgagcaaa gccccgtttg gtggcaacct gagcgtgagc 1200
gaacgtattg cgaacacctg caccgatctg ggcctgattg tgcgtgcgct gggccagagc 1260
gtggcgctgt gcccgccgtt tattctgacc gaagtgcaga tggatgaaat gttcgataaa 1320
ctggaaaaag cgctggataa agtgttcgcg gaagtggcg                        1359

 
<210> 56
<211> 453
<212> PRT
<213> Artificial Sequence
 
<220>
<223> variant of transaminase from Vibrio fluvialis Js17
 
<400> 56
Met Asn Lys Pro Gln Ser Trp Glu Thr Arg Ala Glu Thr Tyr Ser Leu 
1               5                   10                  15      
Tyr Gly Phe Thr Asp Met Pro Ser Leu His Gln Arg Gly Thr Val Val 
            20                  25                  30          
Val Thr His Gly Glu Gly Pro Tyr Ile Val Asp Val His Gly Arg Arg 
        35                  40                  45              
Tyr Leu Asp Ala Cys Ser Gly Ala Leu Asn Met Val Ala Gly Phe Asp 
    50                  55                  60                  
His Lys Gly Leu Ile Asp Ala Ala Lys Thr Gln Tyr Glu Arg Phe Pro 
65                  70                  75                  80  
Gly Tyr His Ala Val Ala Gly Arg Met Ser Asp Gln Thr Val Met Leu 
                85                  90                  95      
Ser Glu Lys Leu Val Glu Val Ser Pro Phe Asp Ser Gly Arg Val Phe 
            100                 105                 110         
Tyr Thr Asn Ser Gly Ser Glu Ala Asn Asp Thr Met Val Lys Met Leu 
        115                 120                 125             
Trp Phe Leu His Ala Ala Glu Gly Lys Pro Gln Lys Arg Lys Ile Leu 
    130                 135                 140                 
Thr His Trp Asn Ala Tyr His Gly Ala Thr Ala Val Ser Ala Ser Met 
145                 150                 155                 160 
Thr Asp Phe Pro Tyr Asn Ser Val Phe Gly Leu Pro Leu Pro Gly Phe 
                165                 170                 175     
Leu His Leu Thr Cys Pro His Tyr Trp Arg Tyr Gly Glu Glu Gly Glu 
            180                 185                 190         
Thr Glu Glu Gln Phe Val Ala Arg Leu Ala His Glu Leu Glu Glu Thr 
        195                 200                 205             
Ile Gln Lys Glu Gly Ala Asp Thr Ile Ala Gly Phe Phe Ala Glu Pro 
    210                 215                 220                 
Val Met Gly Ala Gly Gly Val Ile Pro Pro Ala Lys Gly Tyr Phe Gln 
225                 230                 235                 240 
Ala Ile Leu Pro Ile Leu Arg Lys Tyr Asp Ile Pro Val Ile Ser Asp 
                245                 250                 255     
Glu Val Ile Cys Gly Phe Gly Arg Thr Gly Asn Thr Trp Gly Cys Val 
            260                 265                 270         
Thr Tyr Asp Phe Thr Pro Asp Ala Ile Ile Ser Ser Lys Ser Leu Thr 
        275                 280                 285             
Ala Gly Phe Phe Pro Val Gly Ala Val Ile Leu Gly Pro Glu Leu Ser 
    290                 295                 300                 
Lys Arg Leu Glu Thr Ala Ile Glu Ala Arg Glu Trp Phe Pro His Gly 
305                 310                 315                 320 
Phe Thr Thr Gly Gly His Pro Val Gly Cys Ala Ile Ala Leu Lys Ala 
                325                 330                 335     
Ile Asp Val Val Met Asn Glu Gly Leu Ala Glu Asn Val Arg Arg Leu 
            340                 345                 350         
Ala Pro Arg Phe Glu Glu Arg Leu Lys His Ile Ala Glu Arg Pro Asn 
        355                 360                 365             
Ile Gly Glu Tyr Arg Gly Ile Gly Phe Met Trp Ala Leu Glu Val Val 
    370                 375                 380                 
Lys Asp Lys Ala Ser Lys Ala Pro Phe Gly Gly Asn Leu Ser Val Ser 
385                 390                 395                 400 
Glu Arg Ile Ala Asn Thr Cys Thr Asp Leu Gly Leu Ile Val Arg Ala 
                405                 410                 415     
Leu Gly Gln Ser Val Ala Leu Cys Pro Pro Phe Ile Leu Thr Glu Val 
            420                 425                 430         
Gln Met Asp Glu Met Phe Asp Lys Leu Glu Lys Ala Leu Asp Lys Val 
        435                 440                 445             
Phe Ala Glu Val Ala                                             
    450                                                         

 
<210> 57
<211> 1359
<212> DNA
<213> Artificial Sequence
 
<220>
<223> variant of transaminase from Vibrio fluvialis Js17
 
<400> 57
atgaacaaac cgcagagctg ggaaacgcgt gcggaaacct atagcctgta tggttttacc 60
gatatgccga gcctgcatca gcgtggcacc gtggtggtga cccatggcga aggcccgtat 120
atcgtggatg tgcatggccg tcgttatctg gatgcgtgca gcggcgctct gaacatggtg 180
gcgggctttg atcataaagg cctgattgat gcggcgaaaa cgcagtatga acgttttccg 240
ggctatcatg cggttgcggg ccgtatgagc gatcagaccg tgatgctgtc tgaaaaactg 300
gtggaagtga gcccgtttga tagcggccgt gtgttttata ccaacagcgg cagcgaagcg 360
aacgatacca tggtgaaaat gctgtggttt ctgcatgcgg cggaaggcaa accgcagaaa 420
cgtaaaattc tgacccattg gaacgcgtat catggcgcga ccgcggtgag cgcgagcatg 480
accggctttc cgtataacag cgtgtttggc ctgccgctgc cgggctttct gcatctgacc 540
tgcccgcatt attggcgtta tggcgaagaa ggcgaaaccg aagaacagtt tgtcgcgcgt 600
ctggcccatg aactggaaga aaccattcag aaggaaggcg cggataccat tgcgggcttt 660
tttgcggaac cggtgatggg tgcgggcggt gttattccgc cggcaaaagg ctattttcag 720
gcgattctgc cgatcctgcg caaatatgat attccggtga tcagcgatga agtgatttgc 780
ggcttcggcc gtaccggtaa cacctggggc tgcgtgacct atgattttac cccggatgcg 840
attattagca gtaaaagcct aaccgcgggt ttttttccgg taggcgcggt gattctgggt 900
ccggaactga gcaaacgtct ggaaaccgcg attgaagcgc gtgaatggtt tccgcatggt 960
tttaccacag gcggccatcc ggtgggttgt gcgattgcgc tgaaagcgat tgatgtggtg 1020
atgaacgaag gcctggccga aaacgtgcgt cgtctggccc cgcgttttga agaacgtctg 1080
aaacatattg cggaacgtcc gaacattggc gaatatcgtg gcattggctt tatgtgggcg 1140
ctggaagtcg tgaaagataa agcgagcaaa gccccgtttg gtgataacct gagcgtgagc 1200
gaacgtattg cgaacacctg caccgatctg ggcctgattg tgcgtgcgct gggccagagc 1260
gtggcgctgt gcccgccgtt tattctgacc gaagtgcaga tggatgaaat gttcgataaa 1320
ctggaaaaag cgctggataa agtgttcgcg gaagtggcg                        1359

 
<210> 58
<211> 453
<212> PRT
<213> Artificial Sequence
 
<220>
<223> variant of transaminase from Vibrio fluvialis Js17
 
<400> 58
Met Asn Lys Pro Gln Ser Trp Glu Thr Arg Ala Glu Thr Tyr Ser Leu 
1               5                   10                  15      
Tyr Gly Phe Thr Asp Met Pro Ser Leu His Gln Arg Gly Thr Val Val 
            20                  25                  30          
Val Thr His Gly Glu Gly Pro Tyr Ile Val Asp Val His Gly Arg Arg 
        35                  40                  45              
Tyr Leu Asp Ala Cys Ser Gly Ala Leu Asn Met Val Ala Gly Phe Asp 
    50                  55                  60                  
His Lys Gly Leu Ile Asp Ala Ala Lys Thr Gln Tyr Glu Arg Phe Pro 
65                  70                  75                  80  
Gly Tyr His Ala Val Ala Gly Arg Met Ser Asp Gln Thr Val Met Leu 
                85                  90                  95      
Ser Glu Lys Leu Val Glu Val Ser Pro Phe Asp Ser Gly Arg Val Phe 
            100                 105                 110         
Tyr Thr Asn Ser Gly Ser Glu Ala Asn Asp Thr Met Val Lys Met Leu 
        115                 120                 125             
Trp Phe Leu His Ala Ala Glu Gly Lys Pro Gln Lys Arg Lys Ile Leu 
    130                 135                 140                 
Thr His Trp Asn Ala Tyr His Gly Ala Thr Ala Val Ser Ala Ser Met 
145                 150                 155                 160 
Thr Gly Phe Pro Tyr Asn Ser Val Phe Gly Leu Pro Leu Pro Gly Phe 
                165                 170                 175     
Leu His Leu Thr Cys Pro His Tyr Trp Arg Tyr Gly Glu Glu Gly Glu 
            180                 185                 190         
Thr Glu Glu Gln Phe Val Ala Arg Leu Ala His Glu Leu Glu Glu Thr 
        195                 200                 205             
Ile Gln Lys Glu Gly Ala Asp Thr Ile Ala Gly Phe Phe Ala Glu Pro 
    210                 215                 220                 
Val Met Gly Ala Gly Gly Val Ile Pro Pro Ala Lys Gly Tyr Phe Gln 
225                 230                 235                 240 
Ala Ile Leu Pro Ile Leu Arg Lys Tyr Asp Ile Pro Val Ile Ser Asp 
                245                 250                 255     
Glu Val Ile Cys Gly Phe Gly Arg Thr Gly Asn Thr Trp Gly Cys Val 
            260                 265                 270         
Thr Tyr Asp Phe Thr Pro Asp Ala Ile Ile Ser Ser Lys Ser Leu Thr 
        275                 280                 285             
Ala Gly Phe Phe Pro Val Gly Ala Val Ile Leu Gly Pro Glu Leu Ser 
    290                 295                 300                 
Lys Arg Leu Glu Thr Ala Ile Glu Ala Arg Glu Trp Phe Pro His Gly 
305                 310                 315                 320 
Phe Thr Thr Gly Gly His Pro Val Gly Cys Ala Ile Ala Leu Lys Ala 
                325                 330                 335     
Ile Asp Val Val Met Asn Glu Gly Leu Ala Glu Asn Val Arg Arg Leu 
            340                 345                 350         
Ala Pro Arg Phe Glu Glu Arg Leu Lys His Ile Ala Glu Arg Pro Asn 
        355                 360                 365             
Ile Gly Glu Tyr Arg Gly Ile Gly Phe Met Trp Ala Leu Glu Val Val 
    370                 375                 380                 
Lys Asp Lys Ala Ser Lys Ala Pro Phe Gly Asp Asn Leu Ser Val Ser 
385                 390                 395                 400 
Glu Arg Ile Ala Asn Thr Cys Thr Asp Leu Gly Leu Ile Val Arg Ala 
                405                 410                 415     
Leu Gly Gln Ser Val Ala Leu Cys Pro Pro Phe Ile Leu Thr Glu Val 
            420                 425                 430         
Gln Met Asp Glu Met Phe Asp Lys Leu Glu Lys Ala Leu Asp Lys Val 
        435                 440                 445             
Phe Ala Glu Val Ala                                             
    450                                                         

 
<210> 59
<211> 1359
<212> DNA
<213> Artificial Sequence
 
<220>
<223> variant of transaminase from Vibrio fluvialis Js17
 
<400> 59
atgaacaaac cgcagagctg ggaaacgcgt gcggaaacct atagcctgta tggttttacc 60
gatatgagca gcctgcatca gcgtggcacc gtggtggtga cccatggcga aggcccgtat 120
atcgtggatg tgcatggccg tcgttatctg gatgcgtgca gcggcgctct gaacatggtg 180
gcgggctttg atcataaagg cctgattgat gcggcgaaaa cgcagtatga acgttttccg 240
ggctatcatg cggttgcggg ccgtatgagc gatcagaccg tgatgctgtc tgaaaaactg 300
gtggaagtga gcccgtttga tagcggccgt gtgttttata ccaacagcgg cagcgaagcg 360
aacgatacca tggtgaaaat gctgtggttt ctgcatgcgg cggaaggcaa accgcagaaa 420
cgtaaaattc tgacccattg gaacgcgtat catggcgcga ccgcggtgag cgcgaccatg 480
accggctttc cgtataacag cgtgtttggc ctgccgctgc cgggctttct gcatctgacc 540
tgcccgcatt attggcgtta tggcgaagaa ggcgaaaccg aagaacagtt tgtcgcgcgt 600
ctggcccatg aactggaaga aaccattcag aaggaaggcg cggataccat tgcgggcttt 660
tttgcggaac cggtgatggg tgcgggcggt gttattccgc cggcaaaagg ctattttcag 720
gcgattctgc cgatcctgcg caaatatgat attccggtga tcagcgatga agtgatttgc 780
ggcttcggcc gtaccggtaa cacctggggc tgcgtgacct atgattttac cccggatgcg 840
attattagca gtaaaagcct aaccgcgggt ttttttccgg taggcgcggt gattctgggt 900
ccggaactga gcaaacgtct ggaaaccgcg attgaagcgc gtgaatggtt tccgcatggt 960
tttaccacag gcggccatcc ggtgggttgt gcgattgcgc tgaaagcgat tgatgtggtg 1020
atgaacgaag gcctggccga aaacgtgcgt cgtctggccc cgcgttttga agaacgtctg 1080
aaacatattg cggaacgtcc gaacattggc gaatatcgtg gcattggctt tatgtgggcg 1140
ctggaagtcg tgaaagataa agcgagcaaa gccccgtttg gtgataacct gagcgtgagc 1200
gaacgtattg cgaacacctg caccgatctg ggcctgattg tgcgtgcgct gggccagagc 1260
gtggcgctgt gcccgccgtt tattctgacc gaagtgcaga tggatgaaat gttcgataaa 1320
ctggaaaaag cgctggataa agtgttcgcg gaagtggcg                        1359

 
<210> 60
<211> 453
<212> PRT
<213> Artificial Sequence
 
<220>
<223> variant of transaminase from Vibrio fluvialis Js17
 
<400> 60
Met Asn Lys Pro Gln Ser Trp Glu Thr Arg Ala Glu Thr Tyr Ser Leu 
1               5                   10                  15      
Tyr Gly Phe Thr Asp Met Ser Ser Leu His Gln Arg Gly Thr Val Val 
            20                  25                  30          
Val Thr His Gly Glu Gly Pro Tyr Ile Val Asp Val His Gly Arg Arg 
        35                  40                  45              
Tyr Leu Asp Ala Cys Ser Gly Ala Leu Asn Met Val Ala Gly Phe Asp 
    50                  55                  60                  
His Lys Gly Leu Ile Asp Ala Ala Lys Thr Gln Tyr Glu Arg Phe Pro 
65                  70                  75                  80  
Gly Tyr His Ala Val Ala Gly Arg Met Ser Asp Gln Thr Val Met Leu 
                85                  90                  95      
Ser Glu Lys Leu Val Glu Val Ser Pro Phe Asp Ser Gly Arg Val Phe 
            100                 105                 110         
Tyr Thr Asn Ser Gly Ser Glu Ala Asn Asp Thr Met Val Lys Met Leu 
        115                 120                 125             
Trp Phe Leu His Ala Ala Glu Gly Lys Pro Gln Lys Arg Lys Ile Leu 
    130                 135                 140                 
Thr His Trp Asn Ala Tyr His Gly Ala Thr Ala Val Ser Ala Thr Met 
145                 150                 155                 160 
Thr Gly Phe Pro Tyr Asn Ser Val Phe Gly Leu Pro Leu Pro Gly Phe 
                165                 170                 175     
Leu His Leu Thr Cys Pro His Tyr Trp Arg Tyr Gly Glu Glu Gly Glu 
            180                 185                 190         
Thr Glu Glu Gln Phe Val Ala Arg Leu Ala His Glu Leu Glu Glu Thr 
        195                 200                 205             
Ile Gln Lys Glu Gly Ala Asp Thr Ile Ala Gly Phe Phe Ala Glu Pro 
    210                 215                 220                 
Val Met Gly Ala Gly Gly Val Ile Pro Pro Ala Lys Gly Tyr Phe Gln 
225                 230                 235                 240 
Ala Ile Leu Pro Ile Leu Arg Lys Tyr Asp Ile Pro Val Ile Ser Asp 
                245                 250                 255     
Glu Val Ile Cys Gly Phe Gly Arg Thr Gly Asn Thr Trp Gly Cys Val 
            260                 265                 270         
Thr Tyr Asp Phe Thr Pro Asp Ala Ile Ile Ser Ser Lys Ser Leu Thr 
        275                 280                 285             
Ala Gly Phe Phe Pro Val Gly Ala Val Ile Leu Gly Pro Glu Leu Ser 
    290                 295                 300                 
Lys Arg Leu Glu Thr Ala Ile Glu Ala Arg Glu Trp Phe Pro His Gly 
305                 310                 315                 320 
Phe Thr Thr Gly Gly His Pro Val Gly Cys Ala Ile Ala Leu Lys Ala 
                325                 330                 335     
Ile Asp Val Val Met Asn Glu Gly Leu Ala Glu Asn Val Arg Arg Leu 
            340                 345                 350         
Ala Pro Arg Phe Glu Glu Arg Leu Lys His Ile Ala Glu Arg Pro Asn 
        355                 360                 365             
Ile Gly Glu Tyr Arg Gly Ile Gly Phe Met Trp Ala Leu Glu Val Val 
    370                 375                 380                 
Lys Asp Lys Ala Ser Lys Ala Pro Phe Gly Asp Asn Leu Ser Val Ser 
385                 390                 395                 400 
Glu Arg Ile Ala Asn Thr Cys Thr Asp Leu Gly Leu Ile Val Arg Ala 
                405                 410                 415     
Leu Gly Gln Ser Val Ala Leu Cys Pro Pro Phe Ile Leu Thr Glu Val 
            420                 425                 430         
Gln Met Asp Glu Met Phe Asp Lys Leu Glu Lys Ala Leu Asp Lys Val 
        435                 440                 445             
Phe Ala Glu Val Ala                                             
    450                                                         

 
<210> 61
<211> 1359
<212> DNA
<213> Artificial Sequence
 
<220>
<223> variant of transaminase from Vibrio fluvialis Js17
 
<400> 61
atgaacaaac cgcagagctg ggaaacgcgt gcggaaacct atagcctgta tggttttacc 60
ccgatgagca gcctgcatca gcgtggcacc gtggtggtga cccatggcga aggcccgtat 120
atcgtggatg tgcatggccg tcgttatctg gatgcgtgca gcggcgctct gaacatggtg 180
gcgggctttg atcataaagg cctgattgat gcggcgaaaa cgcagtatga acgttttccg 240
ggctatcatg cggttgcggg ccgtatgagc gatcagaccg tgatgctgtc tgaaaaactg 300
gtggaagtga gcccgtttga tagcggccgt gtgttttata ccaacagcgg cagcgaagcg 360
aacgatacca tggtgaaaat gctgtggttt ctgcatgcgg cggaaggcaa accgcagaaa 420
cgtaaaattc tgacccgttg gaacgcgtat catggcgcga ccgcggtgag cgcgagcatg 480
accggctttc cgtataacag cgtgtttggc ctgccgctgc cgggctttct gcatctgacc 540
tgcccgcatt attggcgtta tggcgaagaa ggcgaaaccg aagaacagtt tgtcgcgcgt 600
ctggcccatg aactggaaga aaccattcag aaggaaggcg cggataccat tgcgggcttt 660
tttgcggaac cggtgatggg tgcgggcggt gttattccgc cggcaaaagg ctattttcag 720
gcgattctgc cgatcctgcg caaatatgat attccggtga tcagcgatga agtgatttgc 780
ggcttcggcc gtaccggtaa cacctggggc tgcgtgacct atgattttac cccggatgcg 840
attattagca gtaaaagcct aaccgcgggt ttttttccgg taggcgcggt gattctgggt 900
ccggaactga gcaaacgtct ggaaaccgcg attgaagcgc gtgaatggtt tccgcatggt 960
tttaccacag gcggccatcc ggtgggttgt gcgattgcgc tgaaagcgat tgatgtggtg 1020
atgaacgaag gcctggccga aaacgtgcgt cgtctggccc cgcgttttga agaacgtctg 1080
aaacatattg cggaacgtcc gaacattggc gaatatcgtg gcattggctt tatgtgggcg 1140
ctggaagtcg tgaaagataa agcgagcaaa gccccgtttg gtgataacct gagcgtgagc 1200
gaacgtattg cgaacacctg caccgatctg ggcctgattg tgcgtgcgct gggccagagc 1260
gtggcgctgt gcccgccgtt tattctgacc gaagtgcaga tggatgaaat gttcgataaa 1320
ctggaaaaag cgctggataa agtgttcgcg gaagtggcg                        1359

 
<210> 62
<211> 453
<212> PRT
<213> Artificial Sequence
 
<220>
<223> variant of transaminase from Vibrio fluvialis Js17
 
<400> 62
Met Asn Lys Pro Gln Ser Trp Glu Thr Arg Ala Glu Thr Tyr Ser Leu 
1               5                   10                  15      
Tyr Gly Phe Thr Pro Met Ser Ser Leu His Gln Arg Gly Thr Val Val 
            20                  25                  30          
Val Thr His Gly Glu Gly Pro Tyr Ile Val Asp Val His Gly Arg Arg 
        35                  40                  45              
Tyr Leu Asp Ala Cys Ser Gly Ala Leu Asn Met Val Ala Gly Phe Asp 
    50                  55                  60                  
His Lys Gly Leu Ile Asp Ala Ala Lys Thr Gln Tyr Glu Arg Phe Pro 
65                  70                  75                  80  
Gly Tyr His Ala Val Ala Gly Arg Met Ser Asp Gln Thr Val Met Leu 
                85                  90                  95      
Ser Glu Lys Leu Val Glu Val Ser Pro Phe Asp Ser Gly Arg Val Phe 
            100                 105                 110         
Tyr Thr Asn Ser Gly Ser Glu Ala Asn Asp Thr Met Val Lys Met Leu 
        115                 120                 125             
Trp Phe Leu His Ala Ala Glu Gly Lys Pro Gln Lys Arg Lys Ile Leu 
    130                 135                 140                 
Thr Arg Trp Asn Ala Tyr His Gly Ala Thr Ala Val Ser Ala Ser Met 
145                 150                 155                 160 
Thr Gly Phe Pro Tyr Asn Ser Val Phe Gly Leu Pro Leu Pro Gly Phe 
                165                 170                 175     
Leu His Leu Thr Cys Pro His Tyr Trp Arg Tyr Gly Glu Glu Gly Glu 
            180                 185                 190         
Thr Glu Glu Gln Phe Val Ala Arg Leu Ala His Glu Leu Glu Glu Thr 
        195                 200                 205             
Ile Gln Lys Glu Gly Ala Asp Thr Ile Ala Gly Phe Phe Ala Glu Pro 
    210                 215                 220                 
Val Met Gly Ala Gly Gly Val Ile Pro Pro Ala Lys Gly Tyr Phe Gln 
225                 230                 235                 240 
Ala Ile Leu Pro Ile Leu Arg Lys Tyr Asp Ile Pro Val Ile Ser Asp 
                245                 250                 255     
Glu Val Ile Cys Gly Phe Gly Arg Thr Gly Asn Thr Trp Gly Cys Val 
            260                 265                 270         
Thr Tyr Asp Phe Thr Pro Asp Ala Ile Ile Ser Ser Lys Ser Leu Thr 
        275                 280                 285             
Ala Gly Phe Phe Pro Val Gly Ala Val Ile Leu Gly Pro Glu Leu Ser 
    290                 295                 300                 
Lys Arg Leu Glu Thr Ala Ile Glu Ala Arg Glu Trp Phe Pro His Gly 
305                 310                 315                 320 
Phe Thr Thr Gly Gly His Pro Val Gly Cys Ala Ile Ala Leu Lys Ala 
                325                 330                 335     
Ile Asp Val Val Met Asn Glu Gly Leu Ala Glu Asn Val Arg Arg Leu 
            340                 345                 350         
Ala Pro Arg Phe Glu Glu Arg Leu Lys His Ile Ala Glu Arg Pro Asn 
        355                 360                 365             
Ile Gly Glu Tyr Arg Gly Ile Gly Phe Met Trp Ala Leu Glu Val Val 
    370                 375                 380                 
Lys Asp Lys Ala Ser Lys Ala Pro Phe Gly Asp Asn Leu Ser Val Ser 
385                 390                 395                 400 
Glu Arg Ile Ala Asn Thr Cys Thr Asp Leu Gly Leu Ile Val Arg Ala 
                405                 410                 415     
Leu Gly Gln Ser Val Ala Leu Cys Pro Pro Phe Ile Leu Thr Glu Val 
            420                 425                 430         
Gln Met Asp Glu Met Phe Asp Lys Leu Glu Lys Ala Leu Asp Lys Val 
        435                 440                 445             
Phe Ala Glu Val Ala                                             
    450                                                         

 
<210> 63
<211> 1359
<212> DNA
<213> Artificial Sequence
 
<220>
<223> variant of transaminase from Vibrio fluvialis Js17
 
<400> 63
atgaacaaac cgcagagctg ggaaacgcgt gcggaaacct atagcctgta tggttttacc 60
gatatgccga gcctgcatca gcgtggcacc gtggtggtga cccatggcga aggcccgtat 120
atcgtggatg tgcatggccg tcgttatctg gatgcgtgca gcggcgctct gaacatggtg 180
gcgggctttg atcataaagg cctgattgat gcggcgaaaa cgcagtatga acgttttccg 240
ggctatcatg cggttgcggg ccgtatgagc gatcagaccg tgatgctgtc tgaaaaactg 300
gtggaagtga gcccgtttga tagcggccgt gtgttttata ccaacagcgg cagcgaagcg 360
aacgatacca tggtgaaaat gctgtggttt ctgcatgcgg cggaaggcaa accgcagaaa 420
cgtaaaattc tgacccattg gaacgcgtat catggcgcga ccgcggtgag cgcgagcatg 480
accgattttc cgtataacag cgtgtttggc ctgccgctgc cgggctttct gcatctgacc 540
tgcccgcatt attggcgtta tggcgaagaa ggcgaaaccg aagaacagtt tgtcgcgcgt 600
ctggcccatg aactggaaga aaccattcag aaggaaggcg cggataccat tgcgggcttt 660
tttgcggaac cggtgatggg tgcgggcggt gttattccgc cggcaaaagg ctattttcag 720
gcgattctgc cgatcctgcg caaatatgat attccggtga tcagcgatga agtgatttgc 780
ggcttcggcc gtaccggtaa cacctggggc tgcgtgacct atgattttac cccggatgcg 840
attattagca gtaaaagcct aaccgcgggt ttttttccgg taggcgcggt gattctgggt 900
ccggaactga gcaaacgtct ggaaaccgcg attgaagcgc gtgaatggtt tccgcatggt 960
tttaccacag gcggccatcc ggtgggttgt gcgattgcgc tgaaagcgat tgatgtggtg 1020
atgaacgaag gcctggccga aaacgtgcgt cgtctggccc cgcgttttga agaacgtctg 1080
aaacatattg cggaacgtcc gaacattggc gaatatcgtg gcattggctt tatgtgggcg 1140
ctggaagtcg tgaaagataa agcgagcaaa gccccgtttg gtgataacct gagcgtgagc 1200
gaacgtattg cgaacacctg caccgatctg ggcctgattg tgcgtgcgct gggccagagc 1260
gtggcgctgt gcccgccgtt tattctgacc gaagcgcaga tggatgaaat gttcgataaa 1320
ctggaaaaag cgctggataa agtgttcgcg gaagtggcg                        1359

 
<210> 64
<211> 453
<212> PRT
<213> Artificial Sequence
 
<220>
<223> variant of transaminase from Vibrio fluvialis Js17
 
<400> 64
Met Asn Lys Pro Gln Ser Trp Glu Thr Arg Ala Glu Thr Tyr Ser Leu 
1               5                   10                  15      
Tyr Gly Phe Thr Asp Met Pro Ser Leu His Gln Arg Gly Thr Val Val 
            20                  25                  30          
Val Thr His Gly Glu Gly Pro Tyr Ile Val Asp Val His Gly Arg Arg 
        35                  40                  45              
Tyr Leu Asp Ala Cys Ser Gly Ala Leu Asn Met Val Ala Gly Phe Asp 
    50                  55                  60                  
His Lys Gly Leu Ile Asp Ala Ala Lys Thr Gln Tyr Glu Arg Phe Pro 
65                  70                  75                  80  
Gly Tyr His Ala Val Ala Gly Arg Met Ser Asp Gln Thr Val Met Leu 
                85                  90                  95      
Ser Glu Lys Leu Val Glu Val Ser Pro Phe Asp Ser Gly Arg Val Phe 
            100                 105                 110         
Tyr Thr Asn Ser Gly Ser Glu Ala Asn Asp Thr Met Val Lys Met Leu 
        115                 120                 125             
Trp Phe Leu His Ala Ala Glu Gly Lys Pro Gln Lys Arg Lys Ile Leu 
    130                 135                 140                 
Thr His Trp Asn Ala Tyr His Gly Ala Thr Ala Val Ser Ala Ser Met 
145                 150                 155                 160 
Thr Asp Phe Pro Tyr Asn Ser Val Phe Gly Leu Pro Leu Pro Gly Phe 
                165                 170                 175     
Leu His Leu Thr Cys Pro His Tyr Trp Arg Tyr Gly Glu Glu Gly Glu 
            180                 185                 190         
Thr Glu Glu Gln Phe Val Ala Arg Leu Ala His Glu Leu Glu Glu Thr 
        195                 200                 205             
Ile Gln Lys Glu Gly Ala Asp Thr Ile Ala Gly Phe Phe Ala Glu Pro 
    210                 215                 220                 
Val Met Gly Ala Gly Gly Val Ile Pro Pro Ala Lys Gly Tyr Phe Gln 
225                 230                 235                 240 
Ala Ile Leu Pro Ile Leu Arg Lys Tyr Asp Ile Pro Val Ile Ser Asp 
                245                 250                 255     
Glu Val Ile Cys Gly Phe Gly Arg Thr Gly Asn Thr Trp Gly Cys Val 
            260                 265                 270         
Thr Tyr Asp Phe Thr Pro Asp Ala Ile Ile Ser Ser Lys Ser Leu Thr 
        275                 280                 285             
Ala Gly Phe Phe Pro Val Gly Ala Val Ile Leu Gly Pro Glu Leu Ser 
    290                 295                 300                 
Lys Arg Leu Glu Thr Ala Ile Glu Ala Arg Glu Trp Phe Pro His Gly 
305                 310                 315                 320 
Phe Thr Thr Gly Gly His Pro Val Gly Cys Ala Ile Ala Leu Lys Ala 
                325                 330                 335     
Ile Asp Val Val Met Asn Glu Gly Leu Ala Glu Asn Val Arg Arg Leu 
            340                 345                 350         
Ala Pro Arg Phe Glu Glu Arg Leu Lys His Ile Ala Glu Arg Pro Asn 
        355                 360                 365             
Ile Gly Glu Tyr Arg Gly Ile Gly Phe Met Trp Ala Leu Glu Val Val 
    370                 375                 380                 
Lys Asp Lys Ala Ser Lys Ala Pro Phe Gly Asp Asn Leu Ser Val Ser 
385                 390                 395                 400 
Glu Arg Ile Ala Asn Thr Cys Thr Asp Leu Gly Leu Ile Val Arg Ala 
                405                 410                 415     
Leu Gly Gln Ser Val Ala Leu Cys Pro Pro Phe Ile Leu Thr Glu Ala 
            420                 425                 430         
Gln Met Asp Glu Met Phe Asp Lys Leu Glu Lys Ala Leu Asp Lys Val 
        435                 440                 445             
Phe Ala Glu Val Ala                                             
    450                                                         

 
<210> 65
<211> 1359
<212> DNA
<213> Artificial Sequence
 
<220>
<223> variant of transaminase from Vibrio fluvialis Js17
 
<400> 65
atgaacaaac cgcagagctg ggaaacgcgt gcggaaacct atagcctgta tggttttacc 60
gatatgccga gcctgcatca gcgtggcacc gtggtggtga cccatggcga aggcccgtat 120
atcgtggatg tgcatggccg tcgttatctg gatgcgtgca gcggcgctct gaacatggtg 180
gcgggctttg atcataaagg cctgattgat gcggcgaaaa cgcagtatga acgttttccg 240
ggctatcatg cggttgcggg ccgtatgagc gatcagaccg tgatgctgtc tgaaaaactg 300
gtggaagtga gcccgtttga tagcggccgt gtgttttata ccaacagcgg cagcgaagcg 360
aacgatacca tggtgaaaat gctgtggttt ctgcatgcgg cggaaggcaa accgcagaaa 420
cgtaaaattc tgacccattg gaacgcgtat catggcgcga ccgcggtgag cgcgagcatg 480
accggcaaac cgtataacag cgtgtttggc ctgccgctgc cgggctttct gcatctgacc 540
tgcccgcatt attggcgtta tggcgaagaa ggcgaaaccg aagaacagtt tgtcgcgcgt 600
ctggcccatg aactggaaga aaccattcag aaggaaggcg cggataccat tgcgggcttt 660
tttgcggaac cggtgatggg tgcgggcggt gttattccgc cggcaaaagg ctattttcag 720
gcgattctgc cgatcctgcg caaatatgat attccggtga tcagcgatga agtgatttgc 780
ggcttcggcc gtaccggtaa cacctggggc tgcgtgacct atgattttac cccggatgcg 840
attattagca gtaaaagcct aaccgcgggt ttttttccgg taggcgcggt gattctgggt 900
ccggaactga gcaaacgtct ggaaaccgcg attgaagcgc gtgaatggtt tccgcatggt 960
tttaccacag gcggccatcc ggtgggttgt gcgattgcgc tgaaagcgat tgatgtggtg 1020
atgaacgaag gcctggccga aaacgtgcgt cgtctggccc cgcgttttga agaacgtctg 1080
aaacatattg cggaacgtcc gaacattggc gaatatcgtg gcattggctt tatgtgggcg 1140
ctggaagtcg tgaaagataa agcgagcaaa gccccgtttg gtgataacct gagcgtgagc 1200
gaacgtattg cgaacacctg caccgatctg ggcctgattg tgcgtgcgct gggccagagc 1260
gtggcgctgt gcccgccgtt tattctgacc gaagcgcaga tggatgaaat gttcgataaa 1320
ctggaaaaag cgctggataa agtgttcgcg gaagtggcg                        1359

 
<210> 66
<211> 453
<212> PRT
<213> Artificial Sequence
 
<220>
<223> variant of transaminase from Vibrio fluvialis Js17
 
<400> 66
Met Asn Lys Pro Gln Ser Trp Glu Thr Arg Ala Glu Thr Tyr Ser Leu 
1               5                   10                  15      
Tyr Gly Phe Thr Asp Met Pro Ser Leu His Gln Arg Gly Thr Val Val 
            20                  25                  30          
Val Thr His Gly Glu Gly Pro Tyr Ile Val Asp Val His Gly Arg Arg 
        35                  40                  45              
Tyr Leu Asp Ala Cys Ser Gly Ala Leu Asn Met Val Ala Gly Phe Asp 
    50                  55                  60                  
His Lys Gly Leu Ile Asp Ala Ala Lys Thr Gln Tyr Glu Arg Phe Pro 
65                  70                  75                  80  
Gly Tyr His Ala Val Ala Gly Arg Met Ser Asp Gln Thr Val Met Leu 
                85                  90                  95      
Ser Glu Lys Leu Val Glu Val Ser Pro Phe Asp Ser Gly Arg Val Phe 
            100                 105                 110         
Tyr Thr Asn Ser Gly Ser Glu Ala Asn Asp Thr Met Val Lys Met Leu 
        115                 120                 125             
Trp Phe Leu His Ala Ala Glu Gly Lys Pro Gln Lys Arg Lys Ile Leu 
    130                 135                 140                 
Thr His Trp Asn Ala Tyr His Gly Ala Thr Ala Val Ser Ala Ser Met 
145                 150                 155                 160 
Thr Gly Lys Pro Tyr Asn Ser Val Phe Gly Leu Pro Leu Pro Gly Phe 
                165                 170                 175     
Leu His Leu Thr Cys Pro His Tyr Trp Arg Tyr Gly Glu Glu Gly Glu 
            180                 185                 190         
Thr Glu Glu Gln Phe Val Ala Arg Leu Ala His Glu Leu Glu Glu Thr 
        195                 200                 205             
Ile Gln Lys Glu Gly Ala Asp Thr Ile Ala Gly Phe Phe Ala Glu Pro 
    210                 215                 220                 
Val Met Gly Ala Gly Gly Val Ile Pro Pro Ala Lys Gly Tyr Phe Gln 
225                 230                 235                 240 
Ala Ile Leu Pro Ile Leu Arg Lys Tyr Asp Ile Pro Val Ile Ser Asp 
                245                 250                 255     
Glu Val Ile Cys Gly Phe Gly Arg Thr Gly Asn Thr Trp Gly Cys Val 
            260                 265                 270         
Thr Tyr Asp Phe Thr Pro Asp Ala Ile Ile Ser Ser Lys Ser Leu Thr 
        275                 280                 285             
Ala Gly Phe Phe Pro Val Gly Ala Val Ile Leu Gly Pro Glu Leu Ser 
    290                 295                 300                 
Lys Arg Leu Glu Thr Ala Ile Glu Ala Arg Glu Trp Phe Pro His Gly 
305                 310                 315                 320 
Phe Thr Thr Gly Gly His Pro Val Gly Cys Ala Ile Ala Leu Lys Ala 
                325                 330                 335     
Ile Asp Val Val Met Asn Glu Gly Leu Ala Glu Asn Val Arg Arg Leu 
            340                 345                 350         
Ala Pro Arg Phe Glu Glu Arg Leu Lys His Ile Ala Glu Arg Pro Asn 
        355                 360                 365             
Ile Gly Glu Tyr Arg Gly Ile Gly Phe Met Trp Ala Leu Glu Val Val 
    370                 375                 380                 
Lys Asp Lys Ala Ser Lys Ala Pro Phe Gly Asp Asn Leu Ser Val Ser 
385                 390                 395                 400 
Glu Arg Ile Ala Asn Thr Cys Thr Asp Leu Gly Leu Ile Val Arg Ala 
                405                 410                 415     
Leu Gly Gln Ser Val Ala Leu Cys Pro Pro Phe Ile Leu Thr Glu Ala 
            420                 425                 430         
Gln Met Asp Glu Met Phe Asp Lys Leu Glu Lys Ala Leu Asp Lys Val 
        435                 440                 445             
Phe Ala Glu Val Ala                                             
    450                                                         

 
<210> 67
<211> 1359
<212> DNA
<213> Artificial Sequence
 
<220>
<223> variant of transaminase from Vibrio fluvialis Js17
 
<400> 67
atgaacaaac cgcagagctg ggaaacgcgt gcggaaacct atagcctgta tggttttacc 60
gatatgccga gcctgcatca gcgtggcacc gtggtggtga cccatggcga aggcccgtat 120
atcgtggatg tgcatggccg tcgttatctg gatgcgtgca gcggcgctct gaacatggtg 180
gcgggctttg atcataaagg cctgattgat gcggcgaaaa cgcagtatga acgttttccg 240
ggctatcatg cggttgcggg ccgtatgagc gatcagaccg tgatgctgtc tgaaaaactg 300
gtggaagtga gcccgtttgt tagcggccgt gtgttttata ccaacagcgg cagcgaagcg 360
aacgatacca tggtgaaaat gctgtggttt ctgcatgcgg cggaaggcaa accgcagaaa 420
cgtaaaattc tgacccattg gaacgcgtat catggcgcga ccgcggtgag cgcgagcatg 480
accggcaaac cgtataacag cgtgtttggc ctgccgctgc cgggctttct gcatctgacc 540
tgcccgcatt attggcgtta tggcgaagaa ggcgaaaccg aagaacagtt tgtcgcgcgt 600
ctggcccatg aactggaaga aaccattcag aaggaaggcg cggataccat tgcgggcttt 660
tttgcggaac cggtgatggg tgcgggcggt gttattccgc cggcaaaagg ctattttcag 720
gcgattctgc cgatcctgcg caaatatgat attccggtga tcagcgatga agtgatttgc 780
ggcttcggcc gtaccggtaa cacctggggc tgcgtgacct atgattttac cccggatgcg 840
attattagca gtaaaagcct aaccgcgggt ttttttccgg taggcgcggt gattctgggt 900
ccggaactga gcaaacgtct ggaaaccgcg attgaagcgc gtgaatggtt tccgcatggt 960
tttaccacag gcggccatcc ggtgggttgt gcgattgcgc tgaaagcgat tgatgtggtg 1020
atgaacgaag gcctggccga aaacgtgcgt cgtctggccc cgcgttttga agaacgtctg 1080
aaacatattg cggaacgtcc gaacattggc gaatatcgtg gcattggctt tatgtgggcg 1140
ctggaagtcg tgaaagataa agcgagcaaa gccccgtttg gtgataacct gagcgtgagc 1200
gaacgtattg cgaacacctg caccgatctg ggcctgattg tgcgtgcgct gggccagagc 1260
gtggcgctgt gcccgccgtt tattctgacc gaagcgcaga tggatgaaat gttcgataaa 1320
ctggaaaaag cgctggataa agtgttcgcg gaagtggcg                        1359

 
<210> 68
<211> 453
<212> PRT
<213> Artificial Sequence
 
<220>
<223> variant of transaminase from Vibrio fluvialis Js17
 
<400> 68
Met Asn Lys Pro Gln Ser Trp Glu Thr Arg Ala Glu Thr Tyr Ser Leu 
1               5                   10                  15      
Tyr Gly Phe Thr Asp Met Pro Ser Leu His Gln Arg Gly Thr Val Val 
            20                  25                  30          
Val Thr His Gly Glu Gly Pro Tyr Ile Val Asp Val His Gly Arg Arg 
        35                  40                  45              
Tyr Leu Asp Ala Cys Ser Gly Ala Leu Asn Met Val Ala Gly Phe Asp 
    50                  55                  60                  
His Lys Gly Leu Ile Asp Ala Ala Lys Thr Gln Tyr Glu Arg Phe Pro 
65                  70                  75                  80  
Gly Tyr His Ala Val Ala Gly Arg Met Ser Asp Gln Thr Val Met Leu 
                85                  90                  95      
Ser Glu Lys Leu Val Glu Val Ser Pro Phe Val Ser Gly Arg Val Phe 
            100                 105                 110         
Tyr Thr Asn Ser Gly Ser Glu Ala Asn Asp Thr Met Val Lys Met Leu 
        115                 120                 125             
Trp Phe Leu His Ala Ala Glu Gly Lys Pro Gln Lys Arg Lys Ile Leu 
    130                 135                 140                 
Thr His Trp Asn Ala Tyr His Gly Ala Thr Ala Val Ser Ala Ser Met 
145                 150                 155                 160 
Thr Gly Lys Pro Tyr Asn Ser Val Phe Gly Leu Pro Leu Pro Gly Phe 
                165                 170                 175     
Leu His Leu Thr Cys Pro His Tyr Trp Arg Tyr Gly Glu Glu Gly Glu 
            180                 185                 190         
Thr Glu Glu Gln Phe Val Ala Arg Leu Ala His Glu Leu Glu Glu Thr 
        195                 200                 205             
Ile Gln Lys Glu Gly Ala Asp Thr Ile Ala Gly Phe Phe Ala Glu Pro 
    210                 215                 220                 
Val Met Gly Ala Gly Gly Val Ile Pro Pro Ala Lys Gly Tyr Phe Gln 
225                 230                 235                 240 
Ala Ile Leu Pro Ile Leu Arg Lys Tyr Asp Ile Pro Val Ile Ser Asp 
                245                 250                 255     
Glu Val Ile Cys Gly Phe Gly Arg Thr Gly Asn Thr Trp Gly Cys Val 
            260                 265                 270         
Thr Tyr Asp Phe Thr Pro Asp Ala Ile Ile Ser Ser Lys Ser Leu Thr 
        275                 280                 285             
Ala Gly Phe Phe Pro Val Gly Ala Val Ile Leu Gly Pro Glu Leu Ser 
    290                 295                 300                 
Lys Arg Leu Glu Thr Ala Ile Glu Ala Arg Glu Trp Phe Pro His Gly 
305                 310                 315                 320 
Phe Thr Thr Gly Gly His Pro Val Gly Cys Ala Ile Ala Leu Lys Ala 
                325                 330                 335     
Ile Asp Val Val Met Asn Glu Gly Leu Ala Glu Asn Val Arg Arg Leu 
            340                 345                 350         
Ala Pro Arg Phe Glu Glu Arg Leu Lys His Ile Ala Glu Arg Pro Asn 
        355                 360                 365             
Ile Gly Glu Tyr Arg Gly Ile Gly Phe Met Trp Ala Leu Glu Val Val 
    370                 375                 380                 
Lys Asp Lys Ala Ser Lys Ala Pro Phe Gly Asp Asn Leu Ser Val Ser 
385                 390                 395                 400 
Glu Arg Ile Ala Asn Thr Cys Thr Asp Leu Gly Leu Ile Val Arg Ala 
                405                 410                 415     
Leu Gly Gln Ser Val Ala Leu Cys Pro Pro Phe Ile Leu Thr Glu Ala 
            420                 425                 430         
Gln Met Asp Glu Met Phe Asp Lys Leu Glu Lys Ala Leu Asp Lys Val 
        435                 440                 445             
Phe Ala Glu Val Ala                                             
    450                                                         

 
<210> 69
<211> 1359
<212> DNA
<213> Artificial Sequence
 
<220>
<223> variant of transaminase from Vibrio fluvialis Js17
 
<400> 69
atgaacaaac cgcagagctg ggaaacgcgt gcggaaacct atagcctgta tggttttacc 60
gatatgccga gcctgcatca gcgtggcacc gtggtggtga cccatggcga aggcccgtat 120
atcgtggatg tgcatggccg tcgttatctg gatgcgtgca gcggcgctct gaacatggtg 180
gcgggctttg atcataaagg cctgattgat gcggcgaaaa cgcagtatga acgttttccg 240
ggctatcatg cggttgcggg ccgtatgagc gatcagaccg tgatgctgtc tgaaaaactg 300
gtggaagtga gcccgtttga tagcggccgt gtgttttata ccaacagcgg cagcgaagcg 360
aacgatacca tggtgaaaat gctgtggttt ctgcatgcgg cggaaggcaa accgcagaaa 420
cgtaaaattc tgacccattg gaacgcgtat catggcgcga ccgcggtgag cgcgagcatg 480
accggcaaac cgtataacag cgtgtttggc ctgccgctgc cgggctttct gcatctgacc 540
tgcccgcatt attggcgtta tggcgaagaa ggcgaaaccg aagaacagtt tgtcgcgcgt 600
ctggcccatg aactggaaga aaccattcag aaggaaggcg cggataccat tgcgggcttt 660
tttgcggaac cggtgatggg tgcgggcggt gttattccgc cggcaaaagg ctattttcag 720
gcgattctgc cgatcctgcg caaatatgat attccggtga tcagcgatga agtgatttgc 780
ggcttcggcc gtaccggtaa cacctggggc tgcgtgacct atgattttac cccggatgcg 840
attattagca gtaaaagcct aaccgcgggt ttttttgcgg taggcgcggt gattctgggt 900
ccggaactga gcaaacgtct ggaaaccgcg attgaagcgc gtgaatggtt tccgcatggt 960
tttaccacag gcggccatcc ggtgggttgt gcgattgcgc tgaaagcgat tgatgtggtg 1020
atgaacgaag gcctggccga aaacgtgcgt cgtctggccc cgcgttttga agaacgtctg 1080
aaacatattg cggaacgtcc gaacattggc gaatatcgtg gcattggctt tatgtgggcg 1140
ctggaagtcg tgaaagataa agcgagcaaa gccccgtttg gtgataacct gagcgtgagc 1200
gaacgtattg cgaacacctg caccgatctg ggcctgattg tgcgtgcgct gggccagagc 1260
gtggcgctgt gcccgccgtt tattctgacc gaagcgcaga tggatgaaat gttcgataaa 1320
ctggaaaaag cgctggataa agtgttcgcg gaagtggcg                        1359

 
<210> 70
<211> 453
<212> PRT
<213> Artificial Sequence
 
<220>
<223> variant of transaminase from Vibrio fluvialis Js17
 
<400> 70
Met Asn Lys Pro Gln Ser Trp Glu Thr Arg Ala Glu Thr Tyr Ser Leu 
1               5                   10                  15      
Tyr Gly Phe Thr Asp Met Pro Ser Leu His Gln Arg Gly Thr Val Val 
            20                  25                  30          
Val Thr His Gly Glu Gly Pro Tyr Ile Val Asp Val His Gly Arg Arg 
        35                  40                  45              
Tyr Leu Asp Ala Cys Ser Gly Ala Leu Asn Met Val Ala Gly Phe Asp 
    50                  55                  60                  
His Lys Gly Leu Ile Asp Ala Ala Lys Thr Gln Tyr Glu Arg Phe Pro 
65                  70                  75                  80  
Gly Tyr His Ala Val Ala Gly Arg Met Ser Asp Gln Thr Val Met Leu 
                85                  90                  95      
Ser Glu Lys Leu Val Glu Val Ser Pro Phe Asp Ser Gly Arg Val Phe 
            100                 105                 110         
Tyr Thr Asn Ser Gly Ser Glu Ala Asn Asp Thr Met Val Lys Met Leu 
        115                 120                 125             
Trp Phe Leu His Ala Ala Glu Gly Lys Pro Gln Lys Arg Lys Ile Leu 
    130                 135                 140                 
Thr His Trp Asn Ala Tyr His Gly Ala Thr Ala Val Ser Ala Ser Met 
145                 150                 155                 160 
Thr Gly Lys Pro Tyr Asn Ser Val Phe Gly Leu Pro Leu Pro Gly Phe 
                165                 170                 175     
Leu His Leu Thr Cys Pro His Tyr Trp Arg Tyr Gly Glu Glu Gly Glu 
            180                 185                 190         
Thr Glu Glu Gln Phe Val Ala Arg Leu Ala His Glu Leu Glu Glu Thr 
        195                 200                 205             
Ile Gln Lys Glu Gly Ala Asp Thr Ile Ala Gly Phe Phe Ala Glu Pro 
    210                 215                 220                 
Val Met Gly Ala Gly Gly Val Ile Pro Pro Ala Lys Gly Tyr Phe Gln 
225                 230                 235                 240 
Ala Ile Leu Pro Ile Leu Arg Lys Tyr Asp Ile Pro Val Ile Ser Asp 
                245                 250                 255     
Glu Val Ile Cys Gly Phe Gly Arg Thr Gly Asn Thr Trp Gly Cys Val 
            260                 265                 270         
Thr Tyr Asp Phe Thr Pro Asp Ala Ile Ile Ser Ser Lys Ser Leu Thr 
        275                 280                 285             
Ala Gly Phe Phe Ala Val Gly Ala Val Ile Leu Gly Pro Glu Leu Ser 
    290                 295                 300                 
Lys Arg Leu Glu Thr Ala Ile Glu Ala Arg Glu Trp Phe Pro His Gly 
305                 310                 315                 320 
Phe Thr Thr Gly Gly His Pro Val Gly Cys Ala Ile Ala Leu Lys Ala 
                325                 330                 335     
Ile Asp Val Val Met Asn Glu Gly Leu Ala Glu Asn Val Arg Arg Leu 
            340                 345                 350         
Ala Pro Arg Phe Glu Glu Arg Leu Lys His Ile Ala Glu Arg Pro Asn 
        355                 360                 365             
Ile Gly Glu Tyr Arg Gly Ile Gly Phe Met Trp Ala Leu Glu Val Val 
    370                 375                 380                 
Lys Asp Lys Ala Ser Lys Ala Pro Phe Gly Asp Asn Leu Ser Val Ser 
385                 390                 395                 400 
Glu Arg Ile Ala Asn Thr Cys Thr Asp Leu Gly Leu Ile Val Arg Ala 
                405                 410                 415     
Leu Gly Gln Ser Val Ala Leu Cys Pro Pro Phe Ile Leu Thr Glu Ala 
            420                 425                 430         
Gln Met Asp Glu Met Phe Asp Lys Leu Glu Lys Ala Leu Asp Lys Val 
        435                 440                 445             
Phe Ala Glu Val Ala                                             
    450                                                         

 
<210> 71
<211> 1359
<212> DNA
<213> Artificial Sequence
 
<220>
<223> variant of transaminase from Vibrio fluvialis Js17
 
<400> 71
atgaacaaac cgcagagctg ggaaacgcgt gcggaaacct atagcctgta tggttttacc 60
gatatgccga gcctgcatca gcgtggcacc gtggtggtga cccatggcga aggcccgtat 120
atcgtggatg tgcatggccg tcgttatctg gatgcgtgca gcggcgctct gaacatggtg 180
gcgggctttg atcataaagg cctgattgat gcggcgaaaa cgcagtatga acgttttccg 240
ggctatcatg cggttgcggg ccgtatgagc gatcagaccg tgatgctgtc tgaaaaactg 300
gtggaagtga gcccgtttga tagcggccgt gtgttttata ccaacagcgg cagcgaagcg 360
aacgatacca tggtgaaaat gctgtggttt ctgcatgcgg cggaaggcaa accgcagaaa 420
cgtaaaattc tgacccattg gaacgcgtat catggcgcga ccgcggtgag cgcgagcatg 480
accggcaaac cgtataacag cgtgtttggc ctgccgctgc cgggctttct gcatctgacc 540
tgcccgcatt attggcgtta tggcgaagaa ggcgaaaccg aagaacagtt tgtcgcgcgt 600
ctggcccatg aactggaaga aaccattcag aaggaaggcg cggataccat tgcgggcttt 660
tttgcggaac cggtgatggg tgcgggcggt gttattccgc cggcaaaagg ctattttcag 720
gcgattctgc cgatcctgcg caaatatgat attccggtga tcagcgatga agtgatttgc 780
ggcttcggcc gtaccggtaa cacctggggc tgcgtgacct atgattttac cccggatgcg 840
agtattagca gtaaaagcct aaccgcgggt ttttttccgg taggcgcggt gattctgggt 900
ccggaactga gcaaacgtct ggaaaccgcg attgaagcgc gtgaatggtt tccgcatggt 960
tttaccacag gcggccatcc ggtgggttgt gcgattgcgc tgaaagcgat tgatgtggtg 1020
atgaacgaag gcctggccga aaacgtgcgt cgtctggccc cgcgttttga agaacgtctg 1080
aaacatattg cggaacgtcc gaacattggc gaatatcgtg gcattggctt tatgtgggcg 1140
ctggaagtcg tgaaagataa agcgagcaaa gccccgtttg gtgataacct gagcgtgagc 1200
gaacgtattg cgaacacctg caccgatctg ggcctgattg tgcgtgcgct gggccagagc 1260
gtggcgctgt gcccgccgtt tattctgacc gaagcgcaga tggatgaaat gttcgataaa 1320
ctggaaaaag cgctggataa agtgttcgcg gaagtggcg                        1359

 
<210> 72
<211> 453
<212> PRT
<213> Artificial Sequence
 
<220>
<223> variant of transaminase from Vibrio fluvialis Js17
 
<400> 72
Met Asn Lys Pro Gln Ser Trp Glu Thr Arg Ala Glu Thr Tyr Ser Leu 
1               5                   10                  15      
Tyr Gly Phe Thr Asp Met Pro Ser Leu His Gln Arg Gly Thr Val Val 
            20                  25                  30          
Val Thr His Gly Glu Gly Pro Tyr Ile Val Asp Val His Gly Arg Arg 
        35                  40                  45              
Tyr Leu Asp Ala Cys Ser Gly Ala Leu Asn Met Val Ala Gly Phe Asp 
    50                  55                  60                  
His Lys Gly Leu Ile Asp Ala Ala Lys Thr Gln Tyr Glu Arg Phe Pro 
65                  70                  75                  80  
Gly Tyr His Ala Val Ala Gly Arg Met Ser Asp Gln Thr Val Met Leu 
                85                  90                  95      
Ser Glu Lys Leu Val Glu Val Ser Pro Phe Asp Ser Gly Arg Val Phe 
            100                 105                 110         
Tyr Thr Asn Ser Gly Ser Glu Ala Asn Asp Thr Met Val Lys Met Leu 
        115                 120                 125             
Trp Phe Leu His Ala Ala Glu Gly Lys Pro Gln Lys Arg Lys Ile Leu 
    130                 135                 140                 
Thr His Trp Asn Ala Tyr His Gly Ala Thr Ala Val Ser Ala Ser Met 
145                 150                 155                 160 
Thr Gly Lys Pro Tyr Asn Ser Val Phe Gly Leu Pro Leu Pro Gly Phe 
                165                 170                 175     
Leu His Leu Thr Cys Pro His Tyr Trp Arg Tyr Gly Glu Glu Gly Glu 
            180                 185                 190         
Thr Glu Glu Gln Phe Val Ala Arg Leu Ala His Glu Leu Glu Glu Thr 
        195                 200                 205             
Ile Gln Lys Glu Gly Ala Asp Thr Ile Ala Gly Phe Phe Ala Glu Pro 
    210                 215                 220                 
Val Met Gly Ala Gly Gly Val Ile Pro Pro Ala Lys Gly Tyr Phe Gln 
225                 230                 235                 240 
Ala Ile Leu Pro Ile Leu Arg Lys Tyr Asp Ile Pro Val Ile Ser Asp 
                245                 250                 255     
Glu Val Ile Cys Gly Phe Gly Arg Thr Gly Asn Thr Trp Gly Cys Val 
            260                 265                 270         
Thr Tyr Asp Phe Thr Pro Asp Ala Ser Ile Ser Ser Lys Ser Leu Thr 
        275                 280                 285             
Ala Gly Phe Phe Pro Val Gly Ala Val Ile Leu Gly Pro Glu Leu Ser 
    290                 295                 300                 
Lys Arg Leu Glu Thr Ala Ile Glu Ala Arg Glu Trp Phe Pro His Gly 
305                 310                 315                 320 
Phe Thr Thr Gly Gly His Pro Val Gly Cys Ala Ile Ala Leu Lys Ala 
                325                 330                 335     
Ile Asp Val Val Met Asn Glu Gly Leu Ala Glu Asn Val Arg Arg Leu 
            340                 345                 350         
Ala Pro Arg Phe Glu Glu Arg Leu Lys His Ile Ala Glu Arg Pro Asn 
        355                 360                 365             
Ile Gly Glu Tyr Arg Gly Ile Gly Phe Met Trp Ala Leu Glu Val Val 
    370                 375                 380                 
Lys Asp Lys Ala Ser Lys Ala Pro Phe Gly Asp Asn Leu Ser Val Ser 
385                 390                 395                 400 
Glu Arg Ile Ala Asn Thr Cys Thr Asp Leu Gly Leu Ile Val Arg Ala 
                405                 410                 415     
Leu Gly Gln Ser Val Ala Leu Cys Pro Pro Phe Ile Leu Thr Glu Ala 
            420                 425                 430         
Gln Met Asp Glu Met Phe Asp Lys Leu Glu Lys Ala Leu Asp Lys Val 
        435                 440                 445             
Phe Ala Glu Val Ala                                             
    450                                                         

 
<210> 73
<211> 1359
<212> DNA
<213> Artificial Sequence
 
<220>
<223> variant of transaminase from Vibrio fluvialis Js17
 
<400> 73
atgaacaaac cgcagagctg ggaaacgcgt gcggaaacct atagcctgta tggttttacc 60
gatatgccga gcctgcatca gcgtggcacc gtggtggtga cccatggcga aggcccgtat 120
atcgtggatg tgcatggccg tcgttatctg gatgcgtgca gcggcgctct gaacatggtg 180
gcgggctttg atcataaagg cctgattgat gcggcgaaaa cgcagtatga acgttttccg 240
ggctatcatg cggttgcggg ccgtatgagc gatcagaccg tgatgctgtc tgaaaaactg 300
gtggaagtga gcccgtttga tagcggccgt gtgttttata ccaacagcgg cagcgaagcg 360
aacgatacca tggtgaaaat gctgtggttt ctgcatgcgg cggaaggcaa accgcagaaa 420
cttaaaattc tgacccattg gaacgcgtat catggcgcga ccgcggtgag cgcgagcatg 480
accggcaaac cgtataacag cgtgtttggc ctgccgctgc cgggctttct gcatctgacc 540
tgcccgcatt attggcgtta tggcgaagaa ggcgaaaccg aagaacagtt tgtcgcgcgt 600
ctggcccatg aactggaaga aaccattcag aaggaaggcg cggataccat tgcgggcttt 660
tttgcggaac cggtgatggg tgcgggcggt gttattccgc cggcaaaagg ctattttcag 720
gcgattctgc cgatcctgcg caaatatgat attccggtga tcagcgatga agtgatttgc 780
ggcttcggcc gtaccggtaa cacctggggc tgcgtgacct atgattttac cccggatgcg 840
attattagca gtaaaagcct aaccgcgggt ttttttccgg taggcgcggt gattctgggt 900
ccggaactga gcaaacgtct ggaaaccgcg attgaagcgc gtgaatggtt tccgcatggt 960
tttaccacag gcggccatcc ggtgggttgt gcgattgcgc tgaaagcgat tgatgtggtg 1020
atgaacgaag gcctggccga aaacgtgcgt cgtctggccc cgcgttttga agaacgtctg 1080
aaacatattg cggaacgtcc gaacattggc gaatatcgtg gcattggctt tatgtgggcg 1140
ctggaagtcg tgaaagataa agcgagcaaa gccccgtttg gtgataacct gagcgtgagc 1200
gaacgtattg cgaacacctg caccgatctg ggcctgattg tgcgtgcgct gggccagagc 1260
gtggcgctgt gcccgccgtt tattctgacc gaagcgcaga tggatgaaat gttcgataaa 1320
ctggaaaaag cgctggataa agtgttcgcg gaagtggcg                        1359

 
<210> 74
<211> 453
<212> PRT
<213> Artificial Sequence
 
<220>
<223> variant of transaminase from Vibrio fluvialis Js17
 
<400> 74
Met Asn Lys Pro Gln Ser Trp Glu Thr Arg Ala Glu Thr Tyr Ser Leu 
1               5                   10                  15      
Tyr Gly Phe Thr Asp Met Pro Ser Leu His Gln Arg Gly Thr Val Val 
            20                  25                  30          
Val Thr His Gly Glu Gly Pro Tyr Ile Val Asp Val His Gly Arg Arg 
        35                  40                  45              
Tyr Leu Asp Ala Cys Ser Gly Ala Leu Asn Met Val Ala Gly Phe Asp 
    50                  55                  60                  
His Lys Gly Leu Ile Asp Ala Ala Lys Thr Gln Tyr Glu Arg Phe Pro 
65                  70                  75                  80  
Gly Tyr His Ala Val Ala Gly Arg Met Ser Asp Gln Thr Val Met Leu 
                85                  90                  95      
Ser Glu Lys Leu Val Glu Val Ser Pro Phe Asp Ser Gly Arg Val Phe 
            100                 105                 110         
Tyr Thr Asn Ser Gly Ser Glu Ala Asn Asp Thr Met Val Lys Met Leu 
        115                 120                 125             
Trp Phe Leu His Ala Ala Glu Gly Lys Pro Gln Lys Leu Lys Ile Leu 
    130                 135                 140                 
Thr His Trp Asn Ala Tyr His Gly Ala Thr Ala Val Ser Ala Ser Met 
145                 150                 155                 160 
Thr Gly Lys Pro Tyr Asn Ser Val Phe Gly Leu Pro Leu Pro Gly Phe 
                165                 170                 175     
Leu His Leu Thr Cys Pro His Tyr Trp Arg Tyr Gly Glu Glu Gly Glu 
            180                 185                 190         
Thr Glu Glu Gln Phe Val Ala Arg Leu Ala His Glu Leu Glu Glu Thr 
        195                 200                 205             
Ile Gln Lys Glu Gly Ala Asp Thr Ile Ala Gly Phe Phe Ala Glu Pro 
    210                 215                 220                 
Val Met Gly Ala Gly Gly Val Ile Pro Pro Ala Lys Gly Tyr Phe Gln 
225                 230                 235                 240 
Ala Ile Leu Pro Ile Leu Arg Lys Tyr Asp Ile Pro Val Ile Ser Asp 
                245                 250                 255     
Glu Val Ile Cys Gly Phe Gly Arg Thr Gly Asn Thr Trp Gly Cys Val 
            260                 265                 270         
Thr Tyr Asp Phe Thr Pro Asp Ala Ile Ile Ser Ser Lys Ser Leu Thr 
        275                 280                 285             
Ala Gly Phe Phe Pro Val Gly Ala Val Ile Leu Gly Pro Glu Leu Ser 
    290                 295                 300                 
Lys Arg Leu Glu Thr Ala Ile Glu Ala Arg Glu Trp Phe Pro His Gly 
305                 310                 315                 320 
Phe Thr Thr Gly Gly His Pro Val Gly Cys Ala Ile Ala Leu Lys Ala 
                325                 330                 335     
Ile Asp Val Val Met Asn Glu Gly Leu Ala Glu Asn Val Arg Arg Leu 
            340                 345                 350         
Ala Pro Arg Phe Glu Glu Arg Leu Lys His Ile Ala Glu Arg Pro Asn 
        355                 360                 365             
Ile Gly Glu Tyr Arg Gly Ile Gly Phe Met Trp Ala Leu Glu Val Val 
    370                 375                 380                 
Lys Asp Lys Ala Ser Lys Ala Pro Phe Gly Asp Asn Leu Ser Val Ser 
385                 390                 395                 400 
Glu Arg Ile Ala Asn Thr Cys Thr Asp Leu Gly Leu Ile Val Arg Ala 
                405                 410                 415     
Leu Gly Gln Ser Val Ala Leu Cys Pro Pro Phe Ile Leu Thr Glu Ala 
            420                 425                 430         
Gln Met Asp Glu Met Phe Asp Lys Leu Glu Lys Ala Leu Asp Lys Val 
        435                 440                 445             
Phe Ala Glu Val Ala                                             
    450                                                         

 
<210> 75
<211> 1359
<212> DNA
<213> Artificial Sequence
 
<220>
<223> variant of transaminase from Vibrio fluvialis Js17
 
<400> 75
atgaacaaac cgcagagctg ggaaacgcgt gcggaaacct atagcctggg gggttttacc 60
gatatgccga gcctgcatca gcgtggcacc acggtggtga cccatggcga aggcccgtat 120
atcgtggatg tgcatggccg tcgttatctg gatgcgtgca gcggcgctct gaacatggtg 180
gcgggctttg atcataaagg cctgattgat gcggcgaaaa cgcagtatga acgttttccg 240
ggctatcatg cggttgcggg ccgtatgagc gatcagaccg tgatgctgtc tgaaaaactg 300
gtggaagtga gcccgtttga tagcggccgt gtgttttata ccaacagcgg cagcgaagcg 360
aacgatacca tggtgaaaat gctgtggttt ctgcatgcgg cggaaggcaa accgcagaaa 420
cgtaaaattc tgacccattg gaacgcgtat catggcgcga ccgcggtgag cgcgagcatg 480
accggcaaac cgtataacag cgtgtttggc ctgccgctgc cgggctttct gcatctgacc 540
tgcccgcatt attggcgtta tggcgaagaa ggcgaaaccg aagaacagtt tgtcgcgcgt 600
ctggcccatg aactggaaga aaccattcag aaggaaggcg cggataccat tgcgggcttt 660
tttgcggaac cggtgatggg tgcgggcggt gttattccgc cggcaaaagg ctattttcag 720
gcgattctgc cgatcctgcg caaatatgat attccggtga tcagcgatga agtgatttgc 780
ggcttcggcc gtaccggtaa cacctggggc tgcgtgacct atgattttac cccggatgcg 840
attattagca gtaaaagcct aaccgcgggt ttttttgcgg taggcgcggt gattctgggt 900
ccggaactga gcaaacgtct ggaaaccgcg attgaagcgc gtgaatggtt tccgcatggt 960
tttaccacag gcggccatcc ggtgggttgt gcgattgcgc tgaaagcgat tgatgtggtg 1020
atgaacgaag gcctggccga aaacgtgcgt cgtctggccc cgcgttttga agaacgtctg 1080
aaacatattg cggaacgtcc gaacattggc gaatatcgtg gcattggctt tatgtgggcg 1140
ctggaagtcg tgaaagataa agcgagcaaa gccccgtttg gtgataacct gagcgtgagc 1200
gaacgtattg cgaacacctg caccgatctg ggcctgattg tgcgtgcgct gggccagagc 1260
gtggcgctgt gcccgccgtt tattctgacc gaagcgcaga tggatgaaat gttcgataaa 1320
ctggaaaaag cgctggataa agtgttcgcg gaagtggcg                        1359

 
<210> 76
<211> 453
<212> PRT
<213> Artificial Sequence
 
<220>
<223> variant of transaminase from Vibrio fluvialis Js17
 
<400> 76
Met Asn Lys Pro Gln Ser Trp Glu Thr Arg Ala Glu Thr Tyr Ser Leu 
1               5                   10                  15      
Gly Gly Phe Thr Asp Met Pro Ser Leu His Gln Arg Gly Thr Thr Val 
            20                  25                  30          
Val Thr His Gly Glu Gly Pro Tyr Ile Val Asp Val His Gly Arg Arg 
        35                  40                  45              
Tyr Leu Asp Ala Cys Ser Gly Ala Leu Asn Met Val Ala Gly Phe Asp 
    50                  55                  60                  
His Lys Gly Leu Ile Asp Ala Ala Lys Thr Gln Tyr Glu Arg Phe Pro 
65                  70                  75                  80  
Gly Tyr His Ala Val Ala Gly Arg Met Ser Asp Gln Thr Val Met Leu 
                85                  90                  95      
Ser Glu Lys Leu Val Glu Val Ser Pro Phe Asp Ser Gly Arg Val Phe 
            100                 105                 110         
Tyr Thr Asn Ser Gly Ser Glu Ala Asn Asp Thr Met Val Lys Met Leu 
        115                 120                 125             
Trp Phe Leu His Ala Ala Glu Gly Lys Pro Gln Lys Arg Lys Ile Leu 
    130                 135                 140                 
Thr His Trp Asn Ala Tyr His Gly Ala Thr Ala Val Ser Ala Ser Met 
145                 150                 155                 160 
Thr Gly Lys Pro Tyr Asn Ser Val Phe Gly Leu Pro Leu Pro Gly Phe 
                165                 170                 175     
Leu His Leu Thr Cys Pro His Tyr Trp Arg Tyr Gly Glu Glu Gly Glu 
            180                 185                 190         
Thr Glu Glu Gln Phe Val Ala Arg Leu Ala His Glu Leu Glu Glu Thr 
        195                 200                 205             
Ile Gln Lys Glu Gly Ala Asp Thr Ile Ala Gly Phe Phe Ala Glu Pro 
    210                 215                 220                 
Val Met Gly Ala Gly Gly Val Ile Pro Pro Ala Lys Gly Tyr Phe Gln 
225                 230                 235                 240 
Ala Ile Leu Pro Ile Leu Arg Lys Tyr Asp Ile Pro Val Ile Ser Asp 
                245                 250                 255     
Glu Val Ile Cys Gly Phe Gly Arg Thr Gly Asn Thr Trp Gly Cys Val 
            260                 265                 270         
Thr Tyr Asp Phe Thr Pro Asp Ala Ile Ile Ser Ser Lys Ser Leu Thr 
        275                 280                 285             
Ala Gly Phe Phe Ala Val Gly Ala Val Ile Leu Gly Pro Glu Leu Ser 
    290                 295                 300                 
Lys Arg Leu Glu Thr Ala Ile Glu Ala Arg Glu Trp Phe Pro His Gly 
305                 310                 315                 320 
Phe Thr Thr Gly Gly His Pro Val Gly Cys Ala Ile Ala Leu Lys Ala 
                325                 330                 335     
Ile Asp Val Val Met Asn Glu Gly Leu Ala Glu Asn Val Arg Arg Leu 
            340                 345                 350         
Ala Pro Arg Phe Glu Glu Arg Leu Lys His Ile Ala Glu Arg Pro Asn 
        355                 360                 365             
Ile Gly Glu Tyr Arg Gly Ile Gly Phe Met Trp Ala Leu Glu Val Val 
    370                 375                 380                 
Lys Asp Lys Ala Ser Lys Ala Pro Phe Gly Asp Asn Leu Ser Val Ser 
385                 390                 395                 400 
Glu Arg Ile Ala Asn Thr Cys Thr Asp Leu Gly Leu Ile Val Arg Ala 
                405                 410                 415     
Leu Gly Gln Ser Val Ala Leu Cys Pro Pro Phe Ile Leu Thr Glu Ala 
            420                 425                 430         
Gln Met Asp Glu Met Phe Asp Lys Leu Glu Lys Ala Leu Asp Lys Val 
        435                 440                 445             
Phe Ala Glu Val Ala                                             
    450                                                         

 
<210> 77
<211> 1359
<212> DNA
<213> Artificial Sequence
 
<220>
<223> variant of transaminase from Vibrio fluvialis Js17
 
<400> 77
atgaacaaac cgcagagctg ggaaacgcgt gcggaaacct atagcctgta tggttttacc 60
gatatgccga gcctgcatca gcgtggcacc gtggtggtga cccatggcga aggcccgtat 120
atcgtggatg tgcatggccg tcgttatctg gatgcgtgca gcggcgctct gaacatggtg 180
gcgggctttg atcataaagg cctgattgat gcggcgaaaa cgcagtatga acgttttccg 240
ggctatcatg cggttgcggg ccgtatgagc gatcagaccg tgatgctgtc tgaaaaactg 300
gtggaagtga gcccgtttga tagcggccgt gtgttttata ccaacagcgg cagcgaagcg 360
aacgatacca tggtgaaaat gctgtggttt ctgcatgcgg cggaaggcaa accgcagaaa 420
cgtaaaattc tgacccattg gaacgcgtat catggcgcga ccgcggtgag cgcgagcatg 480
accggcaaac cgtataacag cgtgtttggc ctgccgctgc cgggctttct gcatctgacc 540
tgcccgcatt attggcgtta tggcgaagaa ggcgaaaccg aagaacagtt tgtcgcgcgt 600
ctggcccatg aactggaaga aaccattcag aaggaaggcg cggataccat tgcgggcttt 660
tttgcggaac cggtgatggg tgcgggcggt gttattgtgc cggcaaaagg ctattttcag 720
gcgattctgc cgatcctgcg caaatatgat attccggtga tcagcgatga agtgatttgc 780
ggcttcggcc gtaccggtaa cacctggggc tgcgtgacct atgattttac cccggatgcg 840
attattagca gtaaaagcct aaccgcgggt ttttttgcgg taggcgcggt gattctgggt 900
ccggaactga gcaaacgtct ggaaaccgcg attgaagcgc gtgaatggtt tccgcatggt 960
tttaccacag gcggccatcc ggtgggttgt gcgattgcgc tgaaagcgat tgatgtggtg 1020
atgaacgaag gcctggccga aaacgtgcgt cgtctggccc cgcgttttga agaacgtctg 1080
aaacatattg cggaacgtcc gaacattggc gaatatcgtg gcattggctt tatgtgggcg 1140
ctggaagtcg tgaaagataa agcgagcaaa gccccgtttg gtgataacct gagcgtgagc 1200
gaacgtattg cgaacacctg caccgatctg ggcctgattg tgcgtgcgct gggccagagc 1260
gtggcgctgt gcccgccgtt tattctgacc gaagcgcaga tggatgaaat gttcgataaa 1320
ctggaaaaag cgctggataa agtgttcgcg gaagtggcg                        1359

 
<210> 78
<211> 453
<212> PRT
<213> Artificial Sequence
 
<220>
<223> variant of transaminase from Vibrio fluvialis Js17
 
<400> 78
Met Asn Lys Pro Gln Ser Trp Glu Thr Arg Ala Glu Thr Tyr Ser Leu 
1               5                   10                  15      
Tyr Gly Phe Thr Asp Met Pro Ser Leu His Gln Arg Gly Thr Val Val 
            20                  25                  30          
Val Thr His Gly Glu Gly Pro Tyr Ile Val Asp Val His Gly Arg Arg 
        35                  40                  45              
Tyr Leu Asp Ala Cys Ser Gly Ala Leu Asn Met Val Ala Gly Phe Asp 
    50                  55                  60                  
His Lys Gly Leu Ile Asp Ala Ala Lys Thr Gln Tyr Glu Arg Phe Pro 
65                  70                  75                  80  
Gly Tyr His Ala Val Ala Gly Arg Met Ser Asp Gln Thr Val Met Leu 
                85                  90                  95      
Ser Glu Lys Leu Val Glu Val Ser Pro Phe Asp Ser Gly Arg Val Phe 
            100                 105                 110         
Tyr Thr Asn Ser Gly Ser Glu Ala Asn Asp Thr Met Val Lys Met Leu 
        115                 120                 125             
Trp Phe Leu His Ala Ala Glu Gly Lys Pro Gln Lys Arg Lys Ile Leu 
    130                 135                 140                 
Thr His Trp Asn Ala Tyr His Gly Ala Thr Ala Val Ser Ala Ser Met 
145                 150                 155                 160 
Thr Gly Lys Pro Tyr Asn Ser Val Phe Gly Leu Pro Leu Pro Gly Phe 
                165                 170                 175     
Leu His Leu Thr Cys Pro His Tyr Trp Arg Tyr Gly Glu Glu Gly Glu 
            180                 185                 190         
Thr Glu Glu Gln Phe Val Ala Arg Leu Ala His Glu Leu Glu Glu Thr 
        195                 200                 205             
Ile Gln Lys Glu Gly Ala Asp Thr Ile Ala Gly Phe Phe Ala Glu Pro 
    210                 215                 220                 
Val Met Gly Ala Gly Gly Val Ile Val Pro Ala Lys Gly Tyr Phe Gln 
225                 230                 235                 240 
Ala Ile Leu Pro Ile Leu Arg Lys Tyr Asp Ile Pro Val Ile Ser Asp 
                245                 250                 255     
Glu Val Ile Cys Gly Phe Gly Arg Thr Gly Asn Thr Trp Gly Cys Val 
            260                 265                 270         
Thr Tyr Asp Phe Thr Pro Asp Ala Ile Ile Ser Ser Lys Ser Leu Thr 
        275                 280                 285             
Ala Gly Phe Phe Ala Val Gly Ala Val Ile Leu Gly Pro Glu Leu Ser 
    290                 295                 300                 
Lys Arg Leu Glu Thr Ala Ile Glu Ala Arg Glu Trp Phe Pro His Gly 
305                 310                 315                 320 
Phe Thr Thr Gly Gly His Pro Val Gly Cys Ala Ile Ala Leu Lys Ala 
                325                 330                 335     
Ile Asp Val Val Met Asn Glu Gly Leu Ala Glu Asn Val Arg Arg Leu 
            340                 345                 350         
Ala Pro Arg Phe Glu Glu Arg Leu Lys His Ile Ala Glu Arg Pro Asn 
        355                 360                 365             
Ile Gly Glu Tyr Arg Gly Ile Gly Phe Met Trp Ala Leu Glu Val Val 
    370                 375                 380                 
Lys Asp Lys Ala Ser Lys Ala Pro Phe Gly Asp Asn Leu Ser Val Ser 
385                 390                 395                 400 
Glu Arg Ile Ala Asn Thr Cys Thr Asp Leu Gly Leu Ile Val Arg Ala 
                405                 410                 415     
Leu Gly Gln Ser Val Ala Leu Cys Pro Pro Phe Ile Leu Thr Glu Ala 
            420                 425                 430         
Gln Met Asp Glu Met Phe Asp Lys Leu Glu Lys Ala Leu Asp Lys Val 
        435                 440                 445             
Phe Ala Glu Val Ala                                             
    450                                                         

 
<210> 79
<211> 1359
<212> DNA
<213> Artificial Sequence
 
<220>
<223> variant of transaminase from Vibrio fluvialis Js17
 
<400> 79
atgaacaaac cgcagagctg ggaaacgcgt gcggaaacct atagcctgta tggttttacc 60
gatatgccga gcctgcatca gcgtggcacc gtggtggtga cccatggcga aggcccgtat 120
atcgtggatg tgcatggccg tcgttatctg gatgcgtgca gcggcgctct gaacatggtg 180
gcgggctttg atcataaagg cctgattgat gcggcgaaaa cgcagtatga acgttttccg 240
ggctatcatg cggttgcggg ccgtatgagc gatcagaccg tgatgctgtc tgaaaaactg 300
gtggaagtga gcccgtttga tagcggccgt gtgttttata ccaacagcgg cagcgaagcg 360
aacgatacca tggtgaaaat gctgtggttt ctgcatgcgg cggaaggcaa accgcagaaa 420
cgtaaaattc tgacccattg gaacgcgtat catggcgcga ccgcggtgag cgcgagcatg 480
accggcaaac cgtataacag cgtgtttggc ctgccgctgc cgggctttct gcatctgacc 540
tgcccgcatt attggcgtta tggcgaagaa ggcgaaaccg aagaacagtt tgtcgcgcgt 600
ctggcccatg aactggaaga aaccattcag aaggaaggcg cggataccat tgcgggcttt 660
tttgcggaac cggtgatggg tgcgggcggt gttattccgc cggcaaaagg ctattttcag 720
gcgattctgc cgatcgtgcg caaatatgat attccggtga tcagcgatga agtgatttgc 780
ggcttcggcc gtaccggtaa cacctggggc tgcgtgacct atgattttac cccggatgcg 840
attattagca gtaaaagcct aaccgcgggt ttttttgcgg taggcgcggt gattctgggt 900
ccggaactga gcaaacgtct ggaaaccgcg attgaagcgc gtgaatggtt tccgcatggt 960
tttaccacag gcggccatcc ggtgggttgt gcgattgcgc tgaaagcgat tgatgtggtg 1020
atgaacgaag gcctggccga aaacgtgcgt cgtctggccc cgcgttttga agaacgtctg 1080
aaacatattg cggaacgtcc gaacattggc gaatatcgtg gcattggctt tatgtgggcg 1140
ctggaagtcg tgaaagataa agcgagcaaa gccccgtttg gtgataacct gagcgtgagc 1200
gaacgtattg cgaacacctg caccgatctg ggcctgattg tgcgtgcgct gggccagagc 1260
gtggcgctgt gcccgccgtt tattctgacc gaagcgcaaa tggatgaaat gttcgataaa 1320
ctggaaaaag cgctggataa agtgttcgcg gaagtggcg                        1359

 
<210> 80
<211> 453
<212> PRT
<213> Artificial Sequence
 
<220>
<223> variant of transaminase from Vibrio fluvialis Js17
 
<400> 80
Met Asn Lys Pro Gln Ser Trp Glu Thr Arg Ala Glu Thr Tyr Ser Leu 
1               5                   10                  15      
Tyr Gly Phe Thr Asp Met Pro Ser Leu His Gln Arg Gly Thr Val Val 
            20                  25                  30          
Val Thr His Gly Glu Gly Pro Tyr Ile Val Asp Val His Gly Arg Arg 
        35                  40                  45              
Tyr Leu Asp Ala Cys Ser Gly Ala Leu Asn Met Val Ala Gly Phe Asp 
    50                  55                  60                  
His Lys Gly Leu Ile Asp Ala Ala Lys Thr Gln Tyr Glu Arg Phe Pro 
65                  70                  75                  80  
Gly Tyr His Ala Val Ala Gly Arg Met Ser Asp Gln Thr Val Met Leu 
                85                  90                  95      
Ser Glu Lys Leu Val Glu Val Ser Pro Phe Asp Ser Gly Arg Val Phe 
            100                 105                 110         
Tyr Thr Asn Ser Gly Ser Glu Ala Asn Asp Thr Met Val Lys Met Leu 
        115                 120                 125             
Trp Phe Leu His Ala Ala Glu Gly Lys Pro Gln Lys Arg Lys Ile Leu 
    130                 135                 140                 
Thr His Trp Asn Ala Tyr His Gly Ala Thr Ala Val Ser Ala Ser Met 
145                 150                 155                 160 
Thr Gly Lys Pro Tyr Asn Ser Val Phe Gly Leu Pro Leu Pro Gly Phe 
                165                 170                 175     
Leu His Leu Thr Cys Pro His Tyr Trp Arg Tyr Gly Glu Glu Gly Glu 
            180                 185                 190         
Thr Glu Glu Gln Phe Val Ala Arg Leu Ala His Glu Leu Glu Glu Thr 
        195                 200                 205             
Ile Gln Lys Glu Gly Ala Asp Thr Ile Ala Gly Phe Phe Ala Glu Pro 
    210                 215                 220                 
Val Met Gly Ala Gly Gly Val Ile Pro Pro Ala Lys Gly Tyr Phe Gln 
225                 230                 235                 240 
Ala Ile Leu Pro Ile Val Arg Lys Tyr Asp Ile Pro Val Ile Ser Asp 
                245                 250                 255     
Glu Val Ile Cys Gly Phe Gly Arg Thr Gly Asn Thr Trp Gly Cys Val 
            260                 265                 270         
Thr Tyr Asp Phe Thr Pro Asp Ala Ile Ile Ser Ser Lys Ser Leu Thr 
        275                 280                 285             
Ala Gly Phe Phe Ala Val Gly Ala Val Ile Leu Gly Pro Glu Leu Ser 
    290                 295                 300                 
Lys Arg Leu Glu Thr Ala Ile Glu Ala Arg Glu Trp Phe Pro His Gly 
305                 310                 315                 320 
Phe Thr Thr Gly Gly His Pro Val Gly Cys Ala Ile Ala Leu Lys Ala 
                325                 330                 335     
Ile Asp Val Val Met Asn Glu Gly Leu Ala Glu Asn Val Arg Arg Leu 
            340                 345                 350         
Ala Pro Arg Phe Glu Glu Arg Leu Lys His Ile Ala Glu Arg Pro Asn 
        355                 360                 365             
Ile Gly Glu Tyr Arg Gly Ile Gly Phe Met Trp Ala Leu Glu Val Val 
    370                 375                 380                 
Lys Asp Lys Ala Ser Lys Ala Pro Phe Gly Asp Asn Leu Ser Val Ser 
385                 390                 395                 400 
Glu Arg Ile Ala Asn Thr Cys Thr Asp Leu Gly Leu Ile Val Arg Ala 
                405                 410                 415     
Leu Gly Gln Ser Val Ala Leu Cys Pro Pro Phe Ile Leu Thr Glu Ala 
            420                 425                 430         
Gln Met Asp Glu Met Phe Asp Lys Leu Glu Lys Ala Leu Asp Lys Val 
        435                 440                 445             
Phe Ala Glu Val Ala                                             
    450                                                         

 
<210> 81
<211> 1359
<212> DNA
<213> Artificial Sequence
 
<220>
<223> variant of transaminase from Vibrio fluvialis Js17
 
<400> 81
atgaacaaac cgcagagctg ggaaacgcgt gcggaaacct atagcctgta tggttttacc 60
gatatgccga gcctgcatca gcgtggcacc gtggtggtga cccatggcga aggcccgtat 120
atcgtggatg tgcatggccg tcgttatctg gatgcgtgca gcggcgctct gaacatggtg 180
gcgggctttg atcataaagg cctgattgat gcggcgaaaa cgcagtatga acgttttccg 240
ggctatcatg cggttgcggg ccgtatgagc gatcagaccg tgatgctgtc tgaaaaactg 300
gtggaagtga gcccgtttga tagcggccgt gtgttttata ccaacagcgg cagcgaagcg 360
aacgatacca tggtgaaaat gctgtggttt ctgcatgcgg cggaaggcaa accgcagaaa 420
cgtaaaattc tgacccattg gaacgcgtat catggcgcga ccgcggtgag cgcgagcatg 480
accggcaaac cgtataacag cgtgtttggc ctgccgctgc cgggctttct gcatctgacc 540
tgcccgcatt attggcgtta tggcgaagaa ggcgaaaccg aagaacagtt tgtcgcgcgt 600
ctggcccatg aactggaaga aaccattcag aaggaaggcg cggataccat tgcgggcttt 660
tttgcggaac cggtgatggg tgcgggcggt gttattccgc cggcaaaagg ctattttcag 720
gcgattctgc cgatcctgcg caaatatgat attccggtga tcagcgatga agtgatttgc 780
ggcttcggcc gtaccggtaa cacctggggc tgcgtgacct atgattttac cccggatgcg 840
attattagca gtaaaagcct aaccgcgggt ttttttgcgg taggcgcggt gattctgggt 900
ccggaactga gcaaacgtct ggaaaccgcg attgaagcgc gtgaatggtt tccgcatggt 960
tttaccacag gcggccatcc ggtgggttgt gcgattgcgc tgaaagcgat tgatgtggtg 1020
atgaacgaag gcctggccga aaacgtgcgt cgtctggccc cgcgttttga agaaggtctg 1080
aaacatattg cggaacgtcc gaacattggc gaatatcgtg gcattggctt tatgtgggcg 1140
ctggaagtcg tgaaagataa agcgagcaaa gccccgtttg gtgataacct gagcgtgagc 1200
gaacgtattg cgaacacctg caccgatctg ggcctgattg tgcgtgcgct gggccagagc 1260
gtggcgctgt gcccgccgtt tattctgacc gaagcgcaga tggatgaaat gttcgataaa 1320
ctggaaaaag cgctggataa agtgttcgcg gaagtggcg                        1359

 
<210> 82
<211> 453
<212> PRT
<213> Artificial Sequence
 
<220>
<223> variant of transaminase from Vibrio fluvialis Js17
 
<400> 82
Met Asn Lys Pro Gln Ser Trp Glu Thr Arg Ala Glu Thr Tyr Ser Leu 
1               5                   10                  15      
Tyr Gly Phe Thr Asp Met Pro Ser Leu His Gln Arg Gly Thr Val Val 
            20                  25                  30          
Val Thr His Gly Glu Gly Pro Tyr Ile Val Asp Val His Gly Arg Arg 
        35                  40                  45              
Tyr Leu Asp Ala Cys Ser Gly Ala Leu Asn Met Val Ala Gly Phe Asp 
    50                  55                  60                  
His Lys Gly Leu Ile Asp Ala Ala Lys Thr Gln Tyr Glu Arg Phe Pro 
65                  70                  75                  80  
Gly Tyr His Ala Val Ala Gly Arg Met Ser Asp Gln Thr Val Met Leu 
                85                  90                  95      
Ser Glu Lys Leu Val Glu Val Ser Pro Phe Asp Ser Gly Arg Val Phe 
            100                 105                 110         
Tyr Thr Asn Ser Gly Ser Glu Ala Asn Asp Thr Met Val Lys Met Leu 
        115                 120                 125             
Trp Phe Leu His Ala Ala Glu Gly Lys Pro Gln Lys Arg Lys Ile Leu 
    130                 135                 140                 
Thr His Trp Asn Ala Tyr His Gly Ala Thr Ala Val Ser Ala Ser Met 
145                 150                 155                 160 
Thr Gly Lys Pro Tyr Asn Ser Val Phe Gly Leu Pro Leu Pro Gly Phe 
                165                 170                 175     
Leu His Leu Thr Cys Pro His Tyr Trp Arg Tyr Gly Glu Glu Gly Glu 
            180                 185                 190         
Thr Glu Glu Gln Phe Val Ala Arg Leu Ala His Glu Leu Glu Glu Thr 
        195                 200                 205             
Ile Gln Lys Glu Gly Ala Asp Thr Ile Ala Gly Phe Phe Ala Glu Pro 
    210                 215                 220                 
Val Met Gly Ala Gly Gly Val Ile Pro Pro Ala Lys Gly Tyr Phe Gln 
225                 230                 235                 240 
Ala Ile Leu Pro Ile Leu Arg Lys Tyr Asp Ile Pro Val Ile Ser Asp 
                245                 250                 255     
Glu Val Ile Cys Gly Phe Gly Arg Thr Gly Asn Thr Trp Gly Cys Val 
            260                 265                 270         
Thr Tyr Asp Phe Thr Pro Asp Ala Ile Ile Ser Ser Lys Ser Leu Thr 
        275                 280                 285             
Ala Gly Phe Phe Ala Val Gly Ala Val Ile Leu Gly Pro Glu Leu Ser 
    290                 295                 300                 
Lys Arg Leu Glu Thr Ala Ile Glu Ala Arg Glu Trp Phe Pro His Gly 
305                 310                 315                 320 
Phe Thr Thr Gly Gly His Pro Val Gly Cys Ala Ile Ala Leu Lys Ala 
                325                 330                 335     
Ile Asp Val Val Met Asn Glu Gly Leu Ala Glu Asn Val Arg Arg Leu 
            340                 345                 350         
Ala Pro Arg Phe Glu Glu Gly Leu Lys His Ile Ala Glu Arg Pro Asn 
        355                 360                 365             
Ile Gly Glu Tyr Arg Gly Ile Gly Phe Met Trp Ala Leu Glu Val Val 
    370                 375                 380                 
Lys Asp Lys Ala Ser Lys Ala Pro Phe Gly Asp Asn Leu Ser Val Ser 
385                 390                 395                 400 
Glu Arg Ile Ala Asn Thr Cys Thr Asp Leu Gly Leu Ile Val Arg Ala 
                405                 410                 415     
Leu Gly Gln Ser Val Ala Leu Cys Pro Pro Phe Ile Leu Thr Glu Ala 
            420                 425                 430         
Gln Met Asp Glu Met Phe Asp Lys Leu Glu Lys Ala Leu Asp Lys Val 
        435                 440                 445             
Phe Ala Glu Val Ala                                             
    450                                                         

 
<210> 83
<211> 1359
<212> DNA
<213> Artificial Sequence
 
<220>
<223> variant of transaminase from Vibrio fluvialis Js17
 
<400> 83
atgaacaaac cgcagagctg ggaaacgcgt gcggaaacct atagcctgta tggttttacc 60
gatatgccga gcctgcatca gcgtggcacc gtggtggtga cccatggcga aggcccgtat 120
atcgtggatg tgcatggccg tcgttatctg gatgcgtgca gcggcgctct gaacatggtg 180
gcgggctttg atcataaagg cctgattgat gcggcgaaaa cgcagtatga acgttttccg 240
ggctatcatg cggttgcggg ccgtatgagc gatcagaccg tgatgctgtc tgaaaaactg 300
gtggaagtga gcccgtttga tagcggccgt gtgttttata ccaacagcgg cagcgaagcg 360
aacgatacca tggtgaaaat gctgtggttt ctgcatgcgg cggaaggcaa accgcagaaa 420
cgtaaaattc tgacccattg gaacgcgtat catggcgcga ccgcggtgag cgcgagcatg 480
accggcaaac cgtataacag cgtgtttggc ctgccgctgc cgggctttct gcatctgacc 540
tgcccgcatt attggcgtta tggcgaagaa ggcgaaaccg aagaacagtt tgtcgcgcgt 600
ctggcccatg aactggaaga aaccattcag aaggaaggcg cggataccat tgcgggcttt 660
tttgcggaac cggtgatggg tgcgggcggt gttattccgc cggcaaaagg ctattttcag 720
gcgattctgc cgatcctgcg caaatatgat attccggtga tcagcgatga agtgatttgc 780
ggcttcggcc gtaccggtaa cacctggggc tgcgtgacct atgattttac cccggatgcg 840
attattagca gtaaaagcct aaccgcgggt ttttttgcgg taggcgcggt gattctgggt 900
ccggaactga gcaaacgtct ggaaaccgcg attgaagcgc gtgaatggtt tccgcatggt 960
tttaccacag gcggccatcc ggtgggttgt gcgattgcgc tgaaagcgat tgatgtggtg 1020
atgaacgaag gcctggccga aaacgtgcgt cgtctggccc cgcgttttga agaacgtctg 1080
aaacatattg cggaacgtcc gaacattggc gaatatcgtg gcattggctt tatgtgggcg 1140
ctggaagtcg tgaaagataa agcgagcaaa gccccgtttg gtgataacct gagcgtgagc 1200
gaacgtattg cgaacacctg cgcggatctg ggcctgattg tgcgtgcgct gggccagagc 1260
gtggcgctgt gcccgccgtt tattctgacc gaagcgcaga tggatgaaat gttcgataaa 1320
ctggaaaaag cgctggataa agtgttcgcg gaagtggcg                        1359

 
<210> 84
<211> 453
<212> PRT
<213> Artificial Sequence
 
<220>
<223> variant of transaminase from Vibrio fluvialis Js17
 
<400> 84
Met Asn Lys Pro Gln Ser Trp Glu Thr Arg Ala Glu Thr Tyr Ser Leu 
1               5                   10                  15      
Tyr Gly Phe Thr Asp Met Pro Ser Leu His Gln Arg Gly Thr Val Val 
            20                  25                  30          
Val Thr His Gly Glu Gly Pro Tyr Ile Val Asp Val His Gly Arg Arg 
        35                  40                  45              
Tyr Leu Asp Ala Cys Ser Gly Ala Leu Asn Met Val Ala Gly Phe Asp 
    50                  55                  60                  
His Lys Gly Leu Ile Asp Ala Ala Lys Thr Gln Tyr Glu Arg Phe Pro 
65                  70                  75                  80  
Gly Tyr His Ala Val Ala Gly Arg Met Ser Asp Gln Thr Val Met Leu 
                85                  90                  95      
Ser Glu Lys Leu Val Glu Val Ser Pro Phe Asp Ser Gly Arg Val Phe 
            100                 105                 110         
Tyr Thr Asn Ser Gly Ser Glu Ala Asn Asp Thr Met Val Lys Met Leu 
        115                 120                 125             
Trp Phe Leu His Ala Ala Glu Gly Lys Pro Gln Lys Arg Lys Ile Leu 
    130                 135                 140                 
Thr His Trp Asn Ala Tyr His Gly Ala Thr Ala Val Ser Ala Ser Met 
145                 150                 155                 160 
Thr Gly Lys Pro Tyr Asn Ser Val Phe Gly Leu Pro Leu Pro Gly Phe 
                165                 170                 175     
Leu His Leu Thr Cys Pro His Tyr Trp Arg Tyr Gly Glu Glu Gly Glu 
            180                 185                 190         
Thr Glu Glu Gln Phe Val Ala Arg Leu Ala His Glu Leu Glu Glu Thr 
        195                 200                 205             
Ile Gln Lys Glu Gly Ala Asp Thr Ile Ala Gly Phe Phe Ala Glu Pro 
    210                 215                 220                 
Val Met Gly Ala Gly Gly Val Ile Pro Pro Ala Lys Gly Tyr Phe Gln 
225                 230                 235                 240 
Ala Ile Leu Pro Ile Leu Arg Lys Tyr Asp Ile Pro Val Ile Ser Asp 
                245                 250                 255     
Glu Val Ile Cys Gly Phe Gly Arg Thr Gly Asn Thr Trp Gly Cys Val 
            260                 265                 270         
Thr Tyr Asp Phe Thr Pro Asp Ala Ile Ile Ser Ser Lys Ser Leu Thr 
        275                 280                 285             
Ala Gly Phe Phe Ala Val Gly Ala Val Ile Leu Gly Pro Glu Leu Ser 
    290                 295                 300                 
Lys Arg Leu Glu Thr Ala Ile Glu Ala Arg Glu Trp Phe Pro His Gly 
305                 310                 315                 320 
Phe Thr Thr Gly Gly His Pro Val Gly Cys Ala Ile Ala Leu Lys Ala 
                325                 330                 335     
Ile Asp Val Val Met Asn Glu Gly Leu Ala Glu Asn Val Arg Arg Leu 
            340                 345                 350         
Ala Pro Arg Phe Glu Glu Arg Leu Lys His Ile Ala Glu Arg Pro Asn 
        355                 360                 365             
Ile Gly Glu Tyr Arg Gly Ile Gly Phe Met Trp Ala Leu Glu Val Val 
    370                 375                 380                 
Lys Asp Lys Ala Ser Lys Ala Pro Phe Gly Asp Asn Leu Ser Val Ser 
385                 390                 395                 400 
Glu Arg Ile Ala Asn Thr Cys Ala Asp Leu Gly Leu Ile Val Arg Ala 
                405                 410                 415     
Leu Gly Gln Ser Val Ala Leu Cys Pro Pro Phe Ile Leu Thr Glu Ala 
            420                 425                 430         
Gln Met Asp Glu Met Phe Asp Lys Leu Glu Lys Ala Leu Asp Lys Val 
        435                 440                 445             
Phe Ala Glu Val Ala                                             
    450                                                         

 
<210> 85
<211> 1359
<212> DNA
<213> Artificial Sequence
 
<220>
<223> variant of transaminase from Vibrio fluvialis Js17
 
<400> 85
atgaacaaac cgcagagctg ggaaacgcgt gcggaaacct atagcctgta tggttttacc 60
gatatgccga gcctgcatca gcgtggcacc gtggtggtga cccatggcga aggcccgtat 120
atcgtggatg tgcatggccg tcgttatctg gatgcgtgca gcggcgctct gaacatggtg 180
gcgggctttg atcataaagg cctgattgat gcggcgaaaa cgcagtatga acgttttccg 240
ggctatcatg cggttgcggg ccgtatgagc gatcagaccg tgatgctgtc tgaaaaactg 300
gtggaagtga gcccgtttga tagcggccgt gtgttttata ccaacagcgg cagcgaagcg 360
aacgatacca tggtgaaaat gctgtggttt ctgcatgcgg cggaaggcaa accgcagaaa 420
cgtaaaattc tgacccattg gaacgcgtat catggcgcga ccgcggtgag cgcgagcatg 480
accggcaaac cgtataacag cgtgtttggc ctgccgctgc cgggctttct gcatctgacc 540
tgcccgcatt attggcgtta tggcgaagaa ggcgaaaccg aagaacagtt tgtcgcgcgt 600
ctggcccatg aactggaaga aaccattcag aaggaaggcg cggataccat tgcgggcttt 660
tttgcggaac cggtgatggg tgcgggcggt gttattccgc cggcaaaagg ctattttcag 720
gcgattctgc cgatcctgcg caaatatgat attccggtga tcagcgatga agtgatttgc 780
ggcttcggcc gtaccggtaa cacctggggc tgcgtgacct atgattttac cccggatgcg 840
attattagca gtaaaagcct aaccgcgggt ttttttgcgg taggcgcggt gattctgggt 900
ccggaactga gcaaacgtct ggaaaccgcg attgaagcgc gtgaatggtt tccgcatggt 960
tttaccacag gcggccatcc ggtgggttgt gcgattgcgc tgaaagcgat tgatgtggtg 1020
atgaacgaag gcctggccga aaacgtgcgt cgtctggccc cgcgttttga agaacgtctg 1080
aaacatattg cggaacgtcc gaacattggc gaatatcgtg gcattggctt tatgtgggcg 1140
ctggaagtcg tgaaagataa agcgagcaaa gccccgtttg gtgataacct gagcgtgagc 1200
gaacgtattg cgaacacctg cgttgatctg ggcctgattg tgcgtgcgct gggccagagc 1260
gtggcgctgt gcccgccgtt tattctgacc gaagcgcaga tggatgaaat gttcgataaa 1320
ctggaaaaag cgctggataa agtgttcgcg gaagtggcg                        1359

 
<210> 86
<211> 453
<212> PRT
<213> Artificial Sequence
 
<220>
<223> variant of transaminase from Vibrio fluvialis Js17
 
<400> 86
Met Asn Lys Pro Gln Ser Trp Glu Thr Arg Ala Glu Thr Tyr Ser Leu 
1               5                   10                  15      
Tyr Gly Phe Thr Asp Met Pro Ser Leu His Gln Arg Gly Thr Val Val 
            20                  25                  30          
Val Thr His Gly Glu Gly Pro Tyr Ile Val Asp Val His Gly Arg Arg 
        35                  40                  45              
Tyr Leu Asp Ala Cys Ser Gly Ala Leu Asn Met Val Ala Gly Phe Asp 
    50                  55                  60                  
His Lys Gly Leu Ile Asp Ala Ala Lys Thr Gln Tyr Glu Arg Phe Pro 
65                  70                  75                  80  
Gly Tyr His Ala Val Ala Gly Arg Met Ser Asp Gln Thr Val Met Leu 
                85                  90                  95      
Ser Glu Lys Leu Val Glu Val Ser Pro Phe Asp Ser Gly Arg Val Phe 
            100                 105                 110         
Tyr Thr Asn Ser Gly Ser Glu Ala Asn Asp Thr Met Val Lys Met Leu 
        115                 120                 125             
Trp Phe Leu His Ala Ala Glu Gly Lys Pro Gln Lys Arg Lys Ile Leu 
    130                 135                 140                 
Thr His Trp Asn Ala Tyr His Gly Ala Thr Ala Val Ser Ala Ser Met 
145                 150                 155                 160 
Thr Gly Lys Pro Tyr Asn Ser Val Phe Gly Leu Pro Leu Pro Gly Phe 
                165                 170                 175     
Leu His Leu Thr Cys Pro His Tyr Trp Arg Tyr Gly Glu Glu Gly Glu 
            180                 185                 190         
Thr Glu Glu Gln Phe Val Ala Arg Leu Ala His Glu Leu Glu Glu Thr 
        195                 200                 205             
Ile Gln Lys Glu Gly Ala Asp Thr Ile Ala Gly Phe Phe Ala Glu Pro 
    210                 215                 220                 
Val Met Gly Ala Gly Gly Val Ile Pro Pro Ala Lys Gly Tyr Phe Gln 
225                 230                 235                 240 
Ala Ile Leu Pro Ile Leu Arg Lys Tyr Asp Ile Pro Val Ile Ser Asp 
                245                 250                 255     
Glu Val Ile Cys Gly Phe Gly Arg Thr Gly Asn Thr Trp Gly Cys Val 
            260                 265                 270         
Thr Tyr Asp Phe Thr Pro Asp Ala Ile Ile Ser Ser Lys Ser Leu Thr 
        275                 280                 285             
Ala Gly Phe Phe Ala Val Gly Ala Val Ile Leu Gly Pro Glu Leu Ser 
    290                 295                 300                 
Lys Arg Leu Glu Thr Ala Ile Glu Ala Arg Glu Trp Phe Pro His Gly 
305                 310                 315                 320 
Phe Thr Thr Gly Gly His Pro Val Gly Cys Ala Ile Ala Leu Lys Ala 
                325                 330                 335     
Ile Asp Val Val Met Asn Glu Gly Leu Ala Glu Asn Val Arg Arg Leu 
            340                 345                 350         
Ala Pro Arg Phe Glu Glu Arg Leu Lys His Ile Ala Glu Arg Pro Asn 
        355                 360                 365             
Ile Gly Glu Tyr Arg Gly Ile Gly Phe Met Trp Ala Leu Glu Val Val 
    370                 375                 380                 
Lys Asp Lys Ala Ser Lys Ala Pro Phe Gly Asp Asn Leu Ser Val Ser 
385                 390                 395                 400 
Glu Arg Ile Ala Asn Thr Cys Val Asp Leu Gly Leu Ile Val Arg Ala 
                405                 410                 415     
Leu Gly Gln Ser Val Ala Leu Cys Pro Pro Phe Ile Leu Thr Glu Ala 
            420                 425                 430         
Gln Met Asp Glu Met Phe Asp Lys Leu Glu Lys Ala Leu Asp Lys Val 
        435                 440                 445             
Phe Ala Glu Val Ala                                             
    450                                                         

 
<210> 87
<211> 1359
<212> DNA
<213> Artificial Sequence
 
<220>
<223> variant of transaminase from Vibrio fluvialis Js17
 
<400> 87
atgaacaaac cgcagagctg ggaaacgcgt gcggaaacct atagcctgta tggttttacc 60
gatatgccga gcctgcatca gcgtggcacc gtggtggtga cccatggcga aggcccgtat 120
atcgtggatg tgcatggccg tcgttatctg gatgcgtgca gcggcgctgc gaacatggtg 180
gcgggctttg atcataaagg cctgattgat gcggcgaaaa cgcagtatga acgttttccg 240
ggctatcatg cggttaaagg ccgtatgagc gatcagaccg tgatgctgtc tgaaaaactg 300
gtggaagtga gcccgtttga tagcggccgt gtgttttata ccaacagcgg cagcgaagcg 360
aacgatacca tggtgaaaat gctgtggttt ctgcatgcgg cggaaggcaa accgcagaaa 420
cgtaaaattc tgacccattg gaacgcgtat catggcgcga ccgcggtgag cgcgagcatg 480
accggctttc cgtataacag cgtgtttggc ctgccgctgc cgggctttct gcatctgacc 540
tgcccgcatt attggcgtta tggcgaagaa ggcgaaaccg aagaacagtt tgtcgcgcgt 600
ctggcccatg aactggaaga aaccattcag aaggaaggcg cggataccat tgcgggcttt 660
tttgcggaac cggtgatggg tgcgggcggt gttattccgc cggcaaaagg ctattttcag 720
gcgattctgc cgatcctgcg caaatatgat attccggtga tcagcgatga agtgatttgc 780
ggcttcggcc gtaccggtaa cacctggggc tgcgtgacct atgattttac cccggatgcg 840
attattagca gtaaaagcct aaccgcgggt ttttttgcgg taggcgcggt gattctgggt 900
ccggaactga gcaaacgtct ggaaaccgcg attgaagcgc gtgaatggtt tccgcatggt 960
tttaccacag gcggccatcc ggtgggttgt gcgattgcgc tgaaagcgat tgatgtggtg 1020
atgaacgaag gcctggccga aaacgtgcgt cgtctggccc cgcgttttga agaacgtctg 1080
aaacatattg cggaacgtcc gaacattggc gaatatcgtg gcattggctt tatgtgggcg 1140
ctggaagtcg tgaaagataa agcgagcaaa gccccgtttg gtggcaacct gagcgtgagc 1200
gaacgtattg cgaacacctg caccgatctg ggcctgattg tgcgtgcgct gggccagagc 1260
gtggcgctgt gcccgccgtt tattctgacc gaagcgcaga tggatgaaat gttcgataaa 1320
ctggaaaaag cgctggataa agtgttcgcg gaagtggcg                        1359

 
<210> 88
<211> 453
<212> PRT
<213> Artificial Sequence
 
<220>
<223> variant of transaminase from Vibrio fluvialis Js17
 
<400> 88
Met Asn Lys Pro Gln Ser Trp Glu Thr Arg Ala Glu Thr Tyr Ser Leu 
1               5                   10                  15      
Tyr Gly Phe Thr Asp Met Pro Ser Leu His Gln Arg Gly Thr Val Val 
            20                  25                  30          
Val Thr His Gly Glu Gly Pro Tyr Ile Val Asp Val His Gly Arg Arg 
        35                  40                  45              
Tyr Leu Asp Ala Cys Ser Gly Ala Ala Asn Met Val Ala Gly Phe Asp 
    50                  55                  60                  
His Lys Gly Leu Ile Asp Ala Ala Lys Thr Gln Tyr Glu Arg Phe Pro 
65                  70                  75                  80  
Gly Tyr His Ala Val Lys Gly Arg Met Ser Asp Gln Thr Val Met Leu 
                85                  90                  95      
Ser Glu Lys Leu Val Glu Val Ser Pro Phe Asp Ser Gly Arg Val Phe 
            100                 105                 110         
Tyr Thr Asn Ser Gly Ser Glu Ala Asn Asp Thr Met Val Lys Met Leu 
        115                 120                 125             
Trp Phe Leu His Ala Ala Glu Gly Lys Pro Gln Lys Arg Lys Ile Leu 
    130                 135                 140                 
Thr His Trp Asn Ala Tyr His Gly Ala Thr Ala Val Ser Ala Ser Met 
145                 150                 155                 160 
Thr Gly Phe Pro Tyr Asn Ser Val Phe Gly Leu Pro Leu Pro Gly Phe 
                165                 170                 175     
Leu His Leu Thr Cys Pro His Tyr Trp Arg Tyr Gly Glu Glu Gly Glu 
            180                 185                 190         
Thr Glu Glu Gln Phe Val Ala Arg Leu Ala His Glu Leu Glu Glu Thr 
        195                 200                 205             
Ile Gln Lys Glu Gly Ala Asp Thr Ile Ala Gly Phe Phe Ala Glu Pro 
    210                 215                 220                 
Val Met Gly Ala Gly Gly Val Ile Pro Pro Ala Lys Gly Tyr Phe Gln 
225                 230                 235                 240 
Ala Ile Leu Pro Ile Leu Arg Lys Tyr Asp Ile Pro Val Ile Ser Asp 
                245                 250                 255     
Glu Val Ile Cys Gly Phe Gly Arg Thr Gly Asn Thr Trp Gly Cys Val 
            260                 265                 270         
Thr Tyr Asp Phe Thr Pro Asp Ala Ile Ile Ser Ser Lys Ser Leu Thr 
        275                 280                 285             
Ala Gly Phe Phe Ala Val Gly Ala Val Ile Leu Gly Pro Glu Leu Ser 
    290                 295                 300                 
Lys Arg Leu Glu Thr Ala Ile Glu Ala Arg Glu Trp Phe Pro His Gly 
305                 310                 315                 320 
Phe Thr Thr Gly Gly His Pro Val Gly Cys Ala Ile Ala Leu Lys Ala 
                325                 330                 335     
Ile Asp Val Val Met Asn Glu Gly Leu Ala Glu Asn Val Arg Arg Leu 
            340                 345                 350         
Ala Pro Arg Phe Glu Glu Arg Leu Lys His Ile Ala Glu Arg Pro Asn 
        355                 360                 365             
Ile Gly Glu Tyr Arg Gly Ile Gly Phe Met Trp Ala Leu Glu Val Val 
    370                 375                 380                 
Lys Asp Lys Ala Ser Lys Ala Pro Phe Gly Gly Asn Leu Ser Val Ser 
385                 390                 395                 400 
Glu Arg Ile Ala Asn Thr Cys Thr Asp Leu Gly Leu Ile Val Arg Ala 
                405                 410                 415     
Leu Gly Gln Ser Val Ala Leu Cys Pro Pro Phe Ile Leu Thr Glu Ala 
            420                 425                 430         
Gln Met Asp Glu Met Phe Asp Lys Leu Glu Lys Ala Leu Asp Lys Val 
        435                 440                 445             
Phe Ala Glu Val Ala                                             
    450                                                         

 
<210> 89
<211> 1359
<212> DNA
<213> Artificial Sequence
 
<220>
<223> variant of transaminase from Vibrio fluvialis Js17
 
<400> 89
atgaacaaac cgcagagctg ggaaacgcgt gcggaaacct atagcctgta tggttttacc 60
gatatgccga gcctgcatca gcgtggcacc gtggtggtga cccatggcga aggcccgtat 120
atcgtggatg tgcatggccg tcgttatctg gatgcgtgca gcggcgctgc gaacatggtg 180
gcgggctttg atcataaagg cctgattgat gcggcgaaaa cgcagtatga acgttttccg 240
ggctatcatg cggttaaagg ccgtatgagc gatcagaccg tgatgctgtc tgaaaaactg 300
gtggaagtga gcccgtttga tagcggccgt gtgttttata ccaacagcgg cagcgaagcg 360
aacgatacca tggtgaaaat gctgtggttt ctgcatgcgg cggaaggcaa accgcagaaa 420
cgtaaaattc tgacccattg gaacgcgtat catggcgcga ccgcggtgag cgcgagcatg 480
accggcaaac cgtataacag cgtgtttggc ctgccgctgc cgggctttct gcatctgacc 540
tgcccgcatt attggcgtta tggcgaagaa ggcgaaaccg aagaacagtt tgtcgcgcgt 600
ctggcccatg aactggaaga aaccattcag aaggaaggcg cggataccat tgcgggcttt 660
tttgcggaac cggtgatggg tgcgggcggt gttattccgc cggcaaaagg ctattttcag 720
gcgattctgc cgatcctgcg caaatatgat attccggtga tcagcgatga agtgatttgc 780
ggcttcggcc gtaccggtaa cacctggggc tgcgtgacct atgattttac cccggatgcg 840
attattagca gtaaaagcct aaccgcgggt ttttttccgg taggcgcggt gattctgggt 900
ccggaactga gcaaacgtct ggaaaccgcg attgaagcgc gtgaatggtt tccgcatggt 960
tttaccacag gcggccatcc ggtgggttgt gcgattgcgc tgaaagcgat tgatgtggtg 1020
atgaacgaag gcctggccga aaacgtgcgt cgtctggccc cgcgttttga agaacgtctg 1080
aaacatattg cggaacgtcc gaacattggc gaatatcgtg gcattggctt tatgtgggcg 1140
ctggaagtcg tgaaagataa agcgagcaaa gccccgtttg gtgataacct gagcgtgagc 1200
gaacgtattg cgaacacctg caccgatctg ggcctgattg tgcgtgcgct gggccagagc 1260
gtggcgctgt gcccgccgtt tattctgacc gaagtgcaga tggatgaaat gttcgataaa 1320
ctggaaaaag cgctggataa agtgttcgcg gaagtggcg                        1359

 
<210> 90
<211> 453
<212> PRT
<213> Artificial Sequence
 
<220>
<223> variant of transaminase from Vibrio fluvialis Js17
 
<400> 90
Met Asn Lys Pro Gln Ser Trp Glu Thr Arg Ala Glu Thr Tyr Ser Leu 
1               5                   10                  15      
Tyr Gly Phe Thr Asp Met Pro Ser Leu His Gln Arg Gly Thr Val Val 
            20                  25                  30          
Val Thr His Gly Glu Gly Pro Tyr Ile Val Asp Val His Gly Arg Arg 
        35                  40                  45              
Tyr Leu Asp Ala Cys Ser Gly Ala Ala Asn Met Val Ala Gly Phe Asp 
    50                  55                  60                  
His Lys Gly Leu Ile Asp Ala Ala Lys Thr Gln Tyr Glu Arg Phe Pro 
65                  70                  75                  80  
Gly Tyr His Ala Val Lys Gly Arg Met Ser Asp Gln Thr Val Met Leu 
                85                  90                  95      
Ser Glu Lys Leu Val Glu Val Ser Pro Phe Asp Ser Gly Arg Val Phe 
            100                 105                 110         
Tyr Thr Asn Ser Gly Ser Glu Ala Asn Asp Thr Met Val Lys Met Leu 
        115                 120                 125             
Trp Phe Leu His Ala Ala Glu Gly Lys Pro Gln Lys Arg Lys Ile Leu 
    130                 135                 140                 
Thr His Trp Asn Ala Tyr His Gly Ala Thr Ala Val Ser Ala Ser Met 
145                 150                 155                 160 
Thr Gly Lys Pro Tyr Asn Ser Val Phe Gly Leu Pro Leu Pro Gly Phe 
                165                 170                 175     
Leu His Leu Thr Cys Pro His Tyr Trp Arg Tyr Gly Glu Glu Gly Glu 
            180                 185                 190         
Thr Glu Glu Gln Phe Val Ala Arg Leu Ala His Glu Leu Glu Glu Thr 
        195                 200                 205             
Ile Gln Lys Glu Gly Ala Asp Thr Ile Ala Gly Phe Phe Ala Glu Pro 
    210                 215                 220                 
Val Met Gly Ala Gly Gly Val Ile Pro Pro Ala Lys Gly Tyr Phe Gln 
225                 230                 235                 240 
Ala Ile Leu Pro Ile Leu Arg Lys Tyr Asp Ile Pro Val Ile Ser Asp 
                245                 250                 255     
Glu Val Ile Cys Gly Phe Gly Arg Thr Gly Asn Thr Trp Gly Cys Val 
            260                 265                 270         
Thr Tyr Asp Phe Thr Pro Asp Ala Ile Ile Ser Ser Lys Ser Leu Thr 
        275                 280                 285             
Ala Gly Phe Phe Pro Val Gly Ala Val Ile Leu Gly Pro Glu Leu Ser 
    290                 295                 300                 
Lys Arg Leu Glu Thr Ala Ile Glu Ala Arg Glu Trp Phe Pro His Gly 
305                 310                 315                 320 
Phe Thr Thr Gly Gly His Pro Val Gly Cys Ala Ile Ala Leu Lys Ala 
                325                 330                 335     
Ile Asp Val Val Met Asn Glu Gly Leu Ala Glu Asn Val Arg Arg Leu 
            340                 345                 350         
Ala Pro Arg Phe Glu Glu Arg Leu Lys His Ile Ala Glu Arg Pro Asn 
        355                 360                 365             
Ile Gly Glu Tyr Arg Gly Ile Gly Phe Met Trp Ala Leu Glu Val Val 
    370                 375                 380                 
Lys Asp Lys Ala Ser Lys Ala Pro Phe Gly Asp Asn Leu Ser Val Ser 
385                 390                 395                 400 
Glu Arg Ile Ala Asn Thr Cys Thr Asp Leu Gly Leu Ile Val Arg Ala 
                405                 410                 415     
Leu Gly Gln Ser Val Ala Leu Cys Pro Pro Phe Ile Leu Thr Glu Val 
            420                 425                 430         
Gln Met Asp Glu Met Phe Asp Lys Leu Glu Lys Ala Leu Asp Lys Val 
        435                 440                 445             
Phe Ala Glu Val Ala                                             
    450                                                         

 
<210> 91
<211> 1359
<212> DNA
<213> Artificial Sequence
 
<220>
<223> variant of transaminase from Vibrio fluvialis Js17
 
<400> 91
atgaacaaac cgcagagctg ggaaacgcgt gcggaaacct atagcctgta tggttttacc 60
gatatgagca gcctgcatca gcgtggcacc gtggtggtga cccatggcga aggcccgtat 120
atcgtggatg tgcatggccg tcgttatctg gatgcgtgca gcggcgctgc gaacatggtg 180
gcgggctttg atcataaagg cctgattgat gcggcgaaaa cgcagtatga acgttttccg 240
ggctatcatg cggttaaagg ccgtatgagc gatcagaccg tgatgctgtc tgaaaaactg 300
gtggaagtga gcccgtttga tagcggccgt gtgttttata ccaacagcgg cagcgaagcg 360
aacgatacca tggtgaaaat gctgtggttt ctgcatgcgg cggaaggcaa accgcagaaa 420
cgtaaaattc tgacccattg gaacgcgtat catggcgcga ccgcggtgag cgcgagcatg 480
accggctttc cgtataacag cgtgtttggc ctgccgctgc cgggctttct gcatctgacc 540
tgcccgcatt attggcgtta tggcgaagaa ggcgaaaccg aagaacagtt tgtcgcgcgt 600
ctggcccatg aactggaaga aaccattcag aaggaaggcg cggataccat tgcgggcttt 660
tttgcggaac cggtgatggg tgcgggcggt gttattccgc cggcaaaagg ctattttcag 720
gcgattctgc cgatcctgcg caaatatgat attccggtga tcagcgatga agtgatttgc 780
ggcttcggcc gtaccggtaa cacctggggc tgcgtgacct atgattttac cccggatgcg 840
attattagca gtaaaagcct aaccgcgggt ttttttgcgg taggcgcggt gattctgggt 900
ccggaactga gcaaacgtct ggaaaccgcg attgaagcgc gtgaatggtt tccgcatggt 960
tttaccacag gcggccatcc ggtgggttgt gcgattgcgc tgaaagcgat tgatgtggtg 1020
atgaacgaag gcctggccga aaacgtgcgt cgtctggccc cgcgttttga agaacgtctg 1080
aaacatattg cggaacgtcc gaacattggc gaatatcgtg gcattggctt tatgtgggcg 1140
ctggaagtcg tgaaagataa agcgagcaaa gccccgtttg gtggcaacct gagcgtgagc 1200
gaacgtattg cgaacacctg caccgatctg ggcctgattg tgcgtgcgct gggccagagc 1260
gtggcgctgt gcccgccgtt tattctgacc gaagtgcaga tggatgaaat gttcgataaa 1320
ctggaaaaag cgctggataa agtgttcgcg gaagtggcg                        1359

 
<210> 92
<211> 453
<212> PRT
<213> Artificial Sequence
 
<220>
<223> variant of transaminase from Vibrio fluvialis Js17
 
<400> 92
Met Asn Lys Pro Gln Ser Trp Glu Thr Arg Ala Glu Thr Tyr Ser Leu 
1               5                   10                  15      
Tyr Gly Phe Thr Asp Met Ser Ser Leu His Gln Arg Gly Thr Val Val 
            20                  25                  30          
Val Thr His Gly Glu Gly Pro Tyr Ile Val Asp Val His Gly Arg Arg 
        35                  40                  45              
Tyr Leu Asp Ala Cys Ser Gly Ala Ala Asn Met Val Ala Gly Phe Asp 
    50                  55                  60                  
His Lys Gly Leu Ile Asp Ala Ala Lys Thr Gln Tyr Glu Arg Phe Pro 
65                  70                  75                  80  
Gly Tyr His Ala Val Lys Gly Arg Met Ser Asp Gln Thr Val Met Leu 
                85                  90                  95      
Ser Glu Lys Leu Val Glu Val Ser Pro Phe Asp Ser Gly Arg Val Phe 
            100                 105                 110         
Tyr Thr Asn Ser Gly Ser Glu Ala Asn Asp Thr Met Val Lys Met Leu 
        115                 120                 125             
Trp Phe Leu His Ala Ala Glu Gly Lys Pro Gln Lys Arg Lys Ile Leu 
    130                 135                 140                 
Thr His Trp Asn Ala Tyr His Gly Ala Thr Ala Val Ser Ala Ser Met 
145                 150                 155                 160 
Thr Gly Phe Pro Tyr Asn Ser Val Phe Gly Leu Pro Leu Pro Gly Phe 
                165                 170                 175     
Leu His Leu Thr Cys Pro His Tyr Trp Arg Tyr Gly Glu Glu Gly Glu 
            180                 185                 190         
Thr Glu Glu Gln Phe Val Ala Arg Leu Ala His Glu Leu Glu Glu Thr 
        195                 200                 205             
Ile Gln Lys Glu Gly Ala Asp Thr Ile Ala Gly Phe Phe Ala Glu Pro 
    210                 215                 220                 
Val Met Gly Ala Gly Gly Val Ile Pro Pro Ala Lys Gly Tyr Phe Gln 
225                 230                 235                 240 
Ala Ile Leu Pro Ile Leu Arg Lys Tyr Asp Ile Pro Val Ile Ser Asp 
                245                 250                 255     
Glu Val Ile Cys Gly Phe Gly Arg Thr Gly Asn Thr Trp Gly Cys Val 
            260                 265                 270         
Thr Tyr Asp Phe Thr Pro Asp Ala Ile Ile Ser Ser Lys Ser Leu Thr 
        275                 280                 285             
Ala Gly Phe Phe Ala Val Gly Ala Val Ile Leu Gly Pro Glu Leu Ser 
    290                 295                 300                 
Lys Arg Leu Glu Thr Ala Ile Glu Ala Arg Glu Trp Phe Pro His Gly 
305                 310                 315                 320 
Phe Thr Thr Gly Gly His Pro Val Gly Cys Ala Ile Ala Leu Lys Ala 
                325                 330                 335     
Ile Asp Val Val Met Asn Glu Gly Leu Ala Glu Asn Val Arg Arg Leu 
            340                 345                 350         
Ala Pro Arg Phe Glu Glu Arg Leu Lys His Ile Ala Glu Arg Pro Asn 
        355                 360                 365             
Ile Gly Glu Tyr Arg Gly Ile Gly Phe Met Trp Ala Leu Glu Val Val 
    370                 375                 380                 
Lys Asp Lys Ala Ser Lys Ala Pro Phe Gly Gly Asn Leu Ser Val Ser 
385                 390                 395                 400 
Glu Arg Ile Ala Asn Thr Cys Thr Asp Leu Gly Leu Ile Val Arg Ala 
                405                 410                 415     
Leu Gly Gln Ser Val Ala Leu Cys Pro Pro Phe Ile Leu Thr Glu Val 
            420                 425                 430         
Gln Met Asp Glu Met Phe Asp Lys Leu Glu Lys Ala Leu Asp Lys Val 
        435                 440                 445             
Phe Ala Glu Val Ala                                             
    450                                                         

 
<210> 93
<211> 1359
<212> DNA
<213> Artificial Sequence
 
<220>
<223> variant of transaminase from Vibrio fluvialis Js17
 
<400> 93
atgaacaaac cgcagagctg ggaaacgcgt gcggaaacct atagcctgta tggttttacc 60
gatatgccga gcctgcatca gcgtggcacc gtggtggtga cccatggcga aggcccgtat 120
atcgtggatg tgcatggccg tcgttatctg gatgcgtgca gcggcgctgc gaacatggtg 180
gcgggctttg atcataaagg cctgattgat gcggcgaaaa cgcagtatga acgttttccg 240
ggctatcatg cggttaaagg ccgtatgagc gatcagaccg tgatgctgtc tgaaaaactg 300
gtggaagtga gcccgtttga tagcggccgt gtgttttata ccaacagcgg cagcgaagcg 360
aacgatacca tggtgaaaat gctgtggttt ctgcatgcgg cggaaggcaa accgcagaaa 420
cgtaaaattc tgacccgttg gaacgcgtat catggcgcga ccgcggtgag cgcgagcatg 480
accggcaaac cgtataacag cgtgtttggc ctgccgctgc cgggctttct gcatctgacc 540
tgcccgcatt attggcgtta tggcgaagaa ggcgaaaccg aagaacagtt tgtcgcgcgt 600
ctggcccatg aactggaaga aaccattcag aaggaaggcg cggataccat tgcgggcttt 660
tttgcggaac cggtgatggg tgcgggcggt gttattccgc cggcaaaagg ctattttcag 720
gcgattctgc cgatcctgcg caaatatgat attccggtga tcagcgatga agtgatttgc 780
ggcttcggcc gtaccggtaa cacctggggc tgcgtgacct atgattttac cccggatgcg 840
attattagca gtaaaagcct aaccgcgggt ttttttgcgg taggcgcggt gattctgggt 900
ccggaactga gcaaacgtct ggaaaccgcg attgaagcgc gtgaatggtt tccgcatggt 960
tttaccacag gcggccatcc ggtgggttgt gcgattgcgc tgaaagcgat tgatgtggtg 1020
atgaacgaag gcctggccga aaacgtgcgt cgtctggccc cgcgttttga agaacgtctg 1080
aaacatattg cggaacgtcc gaacattggc gaatatcgtg gcattggctt tatgtgggcg 1140
ctggaagtcg tgaaagataa agcgagcaaa gccccgtttg gtgataacct gagcgtgagc 1200
gaacgtattg cgaacacctg caccgatctg ggcctgattg tgcgtgcgct gggccagagc 1260
gtggcgctgt gcccgccgtt tattctgacc gaagcgcaga tggatgaaat gttcgataaa 1320
ctggaaaaag cgctggataa agtgttcgcg gaagtggcg                        1359

 
<210> 94
<211> 453
<212> PRT
<213> Artificial Sequence
 
<220>
<223> variant of transaminase from Vibrio fluvialis Js17
 
<400> 94
Met Asn Lys Pro Gln Ser Trp Glu Thr Arg Ala Glu Thr Tyr Ser Leu 
1               5                   10                  15      
Tyr Gly Phe Thr Asp Met Pro Ser Leu His Gln Arg Gly Thr Val Val 
            20                  25                  30          
Val Thr His Gly Glu Gly Pro Tyr Ile Val Asp Val His Gly Arg Arg 
        35                  40                  45              
Tyr Leu Asp Ala Cys Ser Gly Ala Ala Asn Met Val Ala Gly Phe Asp 
    50                  55                  60                  
His Lys Gly Leu Ile Asp Ala Ala Lys Thr Gln Tyr Glu Arg Phe Pro 
65                  70                  75                  80  
Gly Tyr His Ala Val Lys Gly Arg Met Ser Asp Gln Thr Val Met Leu 
                85                  90                  95      
Ser Glu Lys Leu Val Glu Val Ser Pro Phe Asp Ser Gly Arg Val Phe 
            100                 105                 110         
Tyr Thr Asn Ser Gly Ser Glu Ala Asn Asp Thr Met Val Lys Met Leu 
        115                 120                 125             
Trp Phe Leu His Ala Ala Glu Gly Lys Pro Gln Lys Arg Lys Ile Leu 
    130                 135                 140                 
Thr Arg Trp Asn Ala Tyr His Gly Ala Thr Ala Val Ser Ala Ser Met 
145                 150                 155                 160 
Thr Gly Lys Pro Tyr Asn Ser Val Phe Gly Leu Pro Leu Pro Gly Phe 
                165                 170                 175     
Leu His Leu Thr Cys Pro His Tyr Trp Arg Tyr Gly Glu Glu Gly Glu 
            180                 185                 190         
Thr Glu Glu Gln Phe Val Ala Arg Leu Ala His Glu Leu Glu Glu Thr 
        195                 200                 205             
Ile Gln Lys Glu Gly Ala Asp Thr Ile Ala Gly Phe Phe Ala Glu Pro 
    210                 215                 220                 
Val Met Gly Ala Gly Gly Val Ile Pro Pro Ala Lys Gly Tyr Phe Gln 
225                 230                 235                 240 
Ala Ile Leu Pro Ile Leu Arg Lys Tyr Asp Ile Pro Val Ile Ser Asp 
                245                 250                 255     
Glu Val Ile Cys Gly Phe Gly Arg Thr Gly Asn Thr Trp Gly Cys Val 
            260                 265                 270         
Thr Tyr Asp Phe Thr Pro Asp Ala Ile Ile Ser Ser Lys Ser Leu Thr 
        275                 280                 285             
Ala Gly Phe Phe Ala Val Gly Ala Val Ile Leu Gly Pro Glu Leu Ser 
    290                 295                 300                 
Lys Arg Leu Glu Thr Ala Ile Glu Ala Arg Glu Trp Phe Pro His Gly 
305                 310                 315                 320 
Phe Thr Thr Gly Gly His Pro Val Gly Cys Ala Ile Ala Leu Lys Ala 
                325                 330                 335     
Ile Asp Val Val Met Asn Glu Gly Leu Ala Glu Asn Val Arg Arg Leu 
            340                 345                 350         
Ala Pro Arg Phe Glu Glu Arg Leu Lys His Ile Ala Glu Arg Pro Asn 
        355                 360                 365             
Ile Gly Glu Tyr Arg Gly Ile Gly Phe Met Trp Ala Leu Glu Val Val 
    370                 375                 380                 
Lys Asp Lys Ala Ser Lys Ala Pro Phe Gly Asp Asn Leu Ser Val Ser 
385                 390                 395                 400 
Glu Arg Ile Ala Asn Thr Cys Thr Asp Leu Gly Leu Ile Val Arg Ala 
                405                 410                 415     
Leu Gly Gln Ser Val Ala Leu Cys Pro Pro Phe Ile Leu Thr Glu Ala 
            420                 425                 430         
Gln Met Asp Glu Met Phe Asp Lys Leu Glu Lys Ala Leu Asp Lys Val 
        435                 440                 445             
Phe Ala Glu Val Ala                                             
    450                                                         

 
<210> 95
<211> 1359
<212> DNA
<213> Artificial Sequence
 
<220>
<223> variant of transaminase from Vibrio fluvialis Js17
 
<400> 95
atgaacaaac cgcagagctg ggaaacgcgt gcggaaacct atagcctgta tggttttacc 60
gatatgccga gcctgcatca gcgtggcacc gtggtggtga cccatggcga aggcccgtat 120
atcgtggatg tgcatggccg tcgttatctg gatgcgtgca gcggcgctgc gaacatggtg 180
gcgggctttg atcataaagg cctgattgat gcggcgaaaa cgcagtatga acgttttccg 240
ggctatcatg cggttaaagg ccgtatgagc gatcagaccg tgatgctgtc tgaaaaactg 300
gtggaagtga gcccgtttga tagcggccgt gtgttttata ccaacagcgg cagcgaagcg 360
aacgatacca tggtgaaaat gctgtggttt ctgcatgcgg cggaaggcaa accgcagaaa 420
cgtaaaattc tgacccattg gaacgcgtat catggcgcga ccgcggtgag cgcgagcatg 480
accggcaaac cgtataacag cgtgtttggc ctgccgctgc cgggctttct gcatctgacc 540
tgcccgcatt attggcgtta tggcgaagaa ggcgaaaccg aagaacagtt tgtcgcgcgt 600
ctggcccatg aactggaaga aaccattcag aaggaaggcg cggataccat tgcgggcttt 660
tttgcggaac cggtgatggg tgcgggcggt gttattccgc cggcaaaagg ctattttcag 720
gcgattctgc cgatcctgcg caaatatgat attccggtga tcagcgatga agtgatttgc 780
ggcttcggcc gtaccggtaa cacctggggc tgcgtgacct atgattttac cccggatgcg 840
attattagca gtaaaagcct aaccgcgggt ttttttgcgg taggcgcggt gattcttggt 900
ccggaactga gcaaacgtct ggaaaccgcg attgaagcgc gtgaatggtt tccgcatggt 960
tttaccacag gcggccatcc ggtgggttgt gcgattgcgc tgaaagcgat tgatgtggtg 1020
atgaacgaag gcctggccga aaacgtgcgt cgtctggccc cgcgttttga agaacgtctg 1080
aaacatattg cggaacgtcc gaacattggc gaatatcgtg gcattggctt tatgtgggcg 1140
ctggaagtcg tgaaagataa agcgagcaaa gccccgtttg gtgataacct gagcgtgagc 1200
gaacgtattg cgaacacctg caccgatctg ggcctgattg tgcgtgcgct gggccagagc 1260
gtggcgctgt gcccgccgtt tattctgacc gaagtgcaga tggatgaaat gttcgataaa 1320
ctggaaaaag cgctggataa agtgttcgcg gaagtggcg                        1359

 
<210> 96
<211> 453
<212> PRT
<213> Artificial Sequence
 
<220>
<223> variant of transaminase from Vibrio fluvialis Js17
 
<400> 96
Met Asn Lys Pro Gln Ser Trp Glu Thr Arg Ala Glu Thr Tyr Ser Leu 
1               5                   10                  15      
Tyr Gly Phe Thr Asp Met Pro Ser Leu His Gln Arg Gly Thr Val Val 
            20                  25                  30          
Val Thr His Gly Glu Gly Pro Tyr Ile Val Asp Val His Gly Arg Arg 
        35                  40                  45              
Tyr Leu Asp Ala Cys Ser Gly Ala Ala Asn Met Val Ala Gly Phe Asp 
    50                  55                  60                  
His Lys Gly Leu Ile Asp Ala Ala Lys Thr Gln Tyr Glu Arg Phe Pro 
65                  70                  75                  80  
Gly Tyr His Ala Val Lys Gly Arg Met Ser Asp Gln Thr Val Met Leu 
                85                  90                  95      
Ser Glu Lys Leu Val Glu Val Ser Pro Phe Asp Ser Gly Arg Val Phe 
            100                 105                 110         
Tyr Thr Asn Ser Gly Ser Glu Ala Asn Asp Thr Met Val Lys Met Leu 
        115                 120                 125             
Trp Phe Leu His Ala Ala Glu Gly Lys Pro Gln Lys Arg Lys Ile Leu 
    130                 135                 140                 
Thr His Trp Asn Ala Tyr His Gly Ala Thr Ala Val Ser Ala Ser Met 
145                 150                 155                 160 
Thr Gly Lys Pro Tyr Asn Ser Val Phe Gly Leu Pro Leu Pro Gly Phe 
                165                 170                 175     
Leu His Leu Thr Cys Pro His Tyr Trp Arg Tyr Gly Glu Glu Gly Glu 
            180                 185                 190         
Thr Glu Glu Gln Phe Val Ala Arg Leu Ala His Glu Leu Glu Glu Thr 
        195                 200                 205             
Ile Gln Lys Glu Gly Ala Asp Thr Ile Ala Gly Phe Phe Ala Glu Pro 
    210                 215                 220                 
Val Met Gly Ala Gly Gly Val Ile Pro Pro Ala Lys Gly Tyr Phe Gln 
225                 230                 235                 240 
Ala Ile Leu Pro Ile Leu Arg Lys Tyr Asp Ile Pro Val Ile Ser Asp 
                245                 250                 255     
Glu Val Ile Cys Gly Phe Gly Arg Thr Gly Asn Thr Trp Gly Cys Val 
            260                 265                 270         
Thr Tyr Asp Phe Thr Pro Asp Ala Ile Ile Ser Ser Lys Ser Leu Thr 
        275                 280                 285             
Ala Gly Phe Phe Ala Val Gly Ala Val Ile Leu Gly Pro Glu Leu Ser 
    290                 295                 300                 
Lys Arg Leu Glu Thr Ala Ile Glu Ala Arg Glu Trp Phe Pro His Gly 
305                 310                 315                 320 
Phe Thr Thr Gly Gly His Pro Val Gly Cys Ala Ile Ala Leu Lys Ala 
                325                 330                 335     
Ile Asp Val Val Met Asn Glu Gly Leu Ala Glu Asn Val Arg Arg Leu 
            340                 345                 350         
Ala Pro Arg Phe Glu Glu Arg Leu Lys His Ile Ala Glu Arg Pro Asn 
        355                 360                 365             
Ile Gly Glu Tyr Arg Gly Ile Gly Phe Met Trp Ala Leu Glu Val Val 
    370                 375                 380                 
Lys Asp Lys Ala Ser Lys Ala Pro Phe Gly Asp Asn Leu Ser Val Ser 
385                 390                 395                 400 
Glu Arg Ile Ala Asn Thr Cys Thr Asp Leu Gly Leu Ile Val Arg Ala 
                405                 410                 415     
Leu Gly Gln Ser Val Ala Leu Cys Pro Pro Phe Ile Leu Thr Glu Val 
            420                 425                 430         
Gln Met Asp Glu Met Phe Asp Lys Leu Glu Lys Ala Leu Asp Lys Val 
        435                 440                 445             
Phe Ala Glu Val Ala                                             
    450                                                         

 
<210> 97
<211> 1359
<212> DNA
<213> Artificial Sequence
 
<220>
<223> variant of transaminase from Vibrio fluvialis Js17
 
<400> 97
atgaacaaac cgcagagctg ggaaacgcgt gcggaaacct atagcctgta tggttttacc 60
gatatgagca gcctgcatca gcgtggcacc gtggtggtga cccatggcga aggcccgtat 120
atcgtggatg tgcatggccg tcgttatctg gatgcgtgca gcggcgctgc gaacatggtg 180
gcgggctttg atcataaagg cctgattgat gcggcgaaaa cgcagtatga acgttttccg 240
ggctatcatg cggttaaagg ccgtatgagc gatcagaccg tgatgctgtc tgaaaaactg 300
gtggaagtga gcccgtttga tagcggccgt gtgttttata ccaacagcgg cagcgaagcg 360
aacgatacca tggtgaaaat gctgtggttt ctgcatgcgg cggaaggcaa accgcagaaa 420
cgtaaaattc tgacccattg gaacgcgtat catggcgcga ccgcggtgag cgcgagcatg 480
accggcaaac cgtataacag cgtgtttggc ctgccgctgc cgggctttct gcatctgacc 540
tgcccgcatt attggcgtta tggcgaagaa ggcgaaaccg aagaacagtt tgtcgcgcgt 600
ctggcccatg aactggaaga aaccattcag aaggaaggcg cggataccat tgcgggcttt 660
tttgcggaac cggtgatggg tgcgggcggt gttattccgc cggcaaaagg ctattttcag 720
gcgattctgc cgatcctgcg caaatatgat attccggtga tcagcgatga agtgatttgc 780
ggcttcggcc gtaccggtaa cacctggggc tgcgtgacct atgattttac cccggatgcg 840
attattagca gtaaaagcct aaccgcgggt ttttttccgg taggcgcggt gattctgggt 900
ccggaactga gcaaacgtct ggaaaccgcg attgaagcgc gtgaatggtt tccgcatggt 960
tttaccacag gcggtcatcc ggtgggttgt gcgattgcgc tgaaagcgat tgatgtggtg 1020
atgaacgaag gcctggccga aaacgtgcgt cgtctggccc cgcgttttga agaacgtctg 1080
aaacatattg cggaacgtcc gaacattggc gaatatcgtg gcattggctt tatgtgggcg 1140
ctggaagtcg tgaaagataa agcgagcaaa gccccgtttg gtggcaacct gagcgtgagc 1200
gaacgtattg cgaacacctg caccgatctg ggcctgattg tgcgtgcgct gggccagagc 1260
gtggcgctgt gcccgccgtt tattctgacc gaagcgcaga tggatgaaat gttcgataaa 1320
ctggaaaaag cgctggataa agtgttcgcg gaagtggcg                        1359

 
<210> 98
<211> 453
<212> PRT
<213> Artificial Sequence
 
<220>
<223> variant of transaminase from Vibrio fluvialis Js17
 
<400> 98
Met Asn Lys Pro Gln Ser Trp Glu Thr Arg Ala Glu Thr Tyr Ser Leu 
1               5                   10                  15      
Tyr Gly Phe Thr Asp Met Ser Ser Leu His Gln Arg Gly Thr Val Val 
            20                  25                  30          
Val Thr His Gly Glu Gly Pro Tyr Ile Val Asp Val His Gly Arg Arg 
        35                  40                  45              
Tyr Leu Asp Ala Cys Ser Gly Ala Ala Asn Met Val Ala Gly Phe Asp 
    50                  55                  60                  
His Lys Gly Leu Ile Asp Ala Ala Lys Thr Gln Tyr Glu Arg Phe Pro 
65                  70                  75                  80  
Gly Tyr His Ala Val Lys Gly Arg Met Ser Asp Gln Thr Val Met Leu 
                85                  90                  95      
Ser Glu Lys Leu Val Glu Val Ser Pro Phe Asp Ser Gly Arg Val Phe 
            100                 105                 110         
Tyr Thr Asn Ser Gly Ser Glu Ala Asn Asp Thr Met Val Lys Met Leu 
        115                 120                 125             
Trp Phe Leu His Ala Ala Glu Gly Lys Pro Gln Lys Arg Lys Ile Leu 
    130                 135                 140                 
Thr His Trp Asn Ala Tyr His Gly Ala Thr Ala Val Ser Ala Ser Met 
145                 150                 155                 160 
Thr Gly Lys Pro Tyr Asn Ser Val Phe Gly Leu Pro Leu Pro Gly Phe 
                165                 170                 175     
Leu His Leu Thr Cys Pro His Tyr Trp Arg Tyr Gly Glu Glu Gly Glu 
            180                 185                 190         
Thr Glu Glu Gln Phe Val Ala Arg Leu Ala His Glu Leu Glu Glu Thr 
        195                 200                 205             
Ile Gln Lys Glu Gly Ala Asp Thr Ile Ala Gly Phe Phe Ala Glu Pro 
    210                 215                 220                 
Val Met Gly Ala Gly Gly Val Ile Pro Pro Ala Lys Gly Tyr Phe Gln 
225                 230                 235                 240 
Ala Ile Leu Pro Ile Leu Arg Lys Tyr Asp Ile Pro Val Ile Ser Asp 
                245                 250                 255     
Glu Val Ile Cys Gly Phe Gly Arg Thr Gly Asn Thr Trp Gly Cys Val 
            260                 265                 270         
Thr Tyr Asp Phe Thr Pro Asp Ala Ile Ile Ser Ser Lys Ser Leu Thr 
        275                 280                 285             
Ala Gly Phe Phe Pro Val Gly Ala Val Ile Leu Gly Pro Glu Leu Ser 
    290                 295                 300                 
Lys Arg Leu Glu Thr Ala Ile Glu Ala Arg Glu Trp Phe Pro His Gly 
305                 310                 315                 320 
Phe Thr Thr Gly Gly His Pro Val Gly Cys Ala Ile Ala Leu Lys Ala 
                325                 330                 335     
Ile Asp Val Val Met Asn Glu Gly Leu Ala Glu Asn Val Arg Arg Leu 
            340                 345                 350         
Ala Pro Arg Phe Glu Glu Arg Leu Lys His Ile Ala Glu Arg Pro Asn 
        355                 360                 365             
Ile Gly Glu Tyr Arg Gly Ile Gly Phe Met Trp Ala Leu Glu Val Val 
    370                 375                 380                 
Lys Asp Lys Ala Ser Lys Ala Pro Phe Gly Gly Asn Leu Ser Val Ser 
385                 390                 395                 400 
Glu Arg Ile Ala Asn Thr Cys Thr Asp Leu Gly Leu Ile Val Arg Ala 
                405                 410                 415     
Leu Gly Gln Ser Val Ala Leu Cys Pro Pro Phe Ile Leu Thr Glu Ala 
            420                 425                 430         
Gln Met Asp Glu Met Phe Asp Lys Leu Glu Lys Ala Leu Asp Lys Val 
        435                 440                 445             
Phe Ala Glu Val Ala                                             
    450                                                         

 
<210> 99
<211> 1359
<212> DNA
<213> Artificial Sequence
 
<220>
<223> variant of transaminase from Vibrio fluvialis Js17
 
<400> 99
atgaacaaac cgcagagctg ggaaacgcgt gcggaaacct atagcctgta tggttttacc 60
gatatgagca gcctgcatca gcgtggcacc gtggtggtga cccatggcga aggcccgtat 120
atcgtggatg tgcatggccg tcgttatctg gatgcgtgca gcggcgctgc gaacatggtg 180
gcgggctttg atcataaagg cctgattgat gcggcgaaaa cgcagtatga acgttttccg 240
ggctatcatg cggttaaagg ccgtatgagc gatcagaccg tgatgctgtc tgaaaaactg 300
gtggaagtga gcccgtttga tagcggccgt gtgttttata ccaacagcgg cagcgaagcg 360
aacgatacca tggtgaaaat gctgtggttt ctgcatgcgg cggaaggcaa accgcagaaa 420
cgtaaaattc tgacccattg gaacgcgtat catggcgcga ccgcggtgag cgcgagcatg 480
accggcaaac cgtataacag cgtgtttggc ctgccgctgc cgggctttct gcatctgacc 540
tgcccgcatt attggcgtta tggcgaagaa ggcgaaaccg aagaacagtt tgtcgcgcgt 600
ctggcccatg aactggaaga aaccattcag aaggaaggcg cggataccat tgcgggcttt 660
tttgcggaac cggtgatggg tgcgggcggt gttattccgc cggcaaaagg ctattttcag 720
gcgattctgc cgatcctgcg caaatatgat attccggtga tcagcgatga agtgatttgc 780
ggcttcggcc gtaccggtaa cacctggggc tgcgtgacct atgattttac cccggatgcg 840
attattagca gtaaaagcct aaccgcgggt ttttttgcgg taggcgcggt gattctgggt 900
ccggaactga gcaaacgtct ggaaaccgcg attgaagcgc gtgaatggtt tccgcatggt 960
tttaccacag gcggccatcc ggtgggttgt gcgattgcgc tgaaagcgat tgatgtggtg 1020
atgaacgaag gcctggccga aaacgtgcgt cgtctggccc cgcgttttga agaacgtctg 1080
aaacatattg cggaacgtcc gaacattggc gaatatcgtg gcattggctt tatgtgggcg 1140
ctggaagtcg tgaaagataa agcgagcaaa gccccgtttg gtggcaacct gagcgtgagc 1200
gaacgtattg cgaacacctg caccgatctg ggcctgattg tgcgtgcgct gggccagagc 1260
gtggcgctgt gcccgccgtt tattctgacc gaagtgcaga tggatgaaat gttcgataaa 1320
ctggaaaaag cgctggataa agtgttcgcg gaagtggcg                        1359

 
<210> 100
<211> 453
<212> PRT
<213> Artificial Sequence
 
<220>
<223> variant of transaminase from Vibrio fluvialis Js17
 
<400> 100
Met Asn Lys Pro Gln Ser Trp Glu Thr Arg Ala Glu Thr Tyr Ser Leu 
1               5                   10                  15      
Tyr Gly Phe Thr Asp Met Ser Ser Leu His Gln Arg Gly Thr Val Val 
            20                  25                  30          
Val Thr His Gly Glu Gly Pro Tyr Ile Val Asp Val His Gly Arg Arg 
        35                  40                  45              
Tyr Leu Asp Ala Cys Ser Gly Ala Ala Asn Met Val Ala Gly Phe Asp 
    50                  55                  60                  
His Lys Gly Leu Ile Asp Ala Ala Lys Thr Gln Tyr Glu Arg Phe Pro 
65                  70                  75                  80  
Gly Tyr His Ala Val Lys Gly Arg Met Ser Asp Gln Thr Val Met Leu 
                85                  90                  95      
Ser Glu Lys Leu Val Glu Val Ser Pro Phe Asp Ser Gly Arg Val Phe 
            100                 105                 110         
Tyr Thr Asn Ser Gly Ser Glu Ala Asn Asp Thr Met Val Lys Met Leu 
        115                 120                 125             
Trp Phe Leu His Ala Ala Glu Gly Lys Pro Gln Lys Arg Lys Ile Leu 
    130                 135                 140                 
Thr His Trp Asn Ala Tyr His Gly Ala Thr Ala Val Ser Ala Ser Met 
145                 150                 155                 160 
Thr Gly Lys Pro Tyr Asn Ser Val Phe Gly Leu Pro Leu Pro Gly Phe 
                165                 170                 175     
Leu His Leu Thr Cys Pro His Tyr Trp Arg Tyr Gly Glu Glu Gly Glu 
            180                 185                 190         
Thr Glu Glu Gln Phe Val Ala Arg Leu Ala His Glu Leu Glu Glu Thr 
        195                 200                 205             
Ile Gln Lys Glu Gly Ala Asp Thr Ile Ala Gly Phe Phe Ala Glu Pro 
    210                 215                 220                 
Val Met Gly Ala Gly Gly Val Ile Pro Pro Ala Lys Gly Tyr Phe Gln 
225                 230                 235                 240 
Ala Ile Leu Pro Ile Leu Arg Lys Tyr Asp Ile Pro Val Ile Ser Asp 
                245                 250                 255     
Glu Val Ile Cys Gly Phe Gly Arg Thr Gly Asn Thr Trp Gly Cys Val 
            260                 265                 270         
Thr Tyr Asp Phe Thr Pro Asp Ala Ile Ile Ser Ser Lys Ser Leu Thr 
        275                 280                 285             
Ala Gly Phe Phe Ala Val Gly Ala Val Ile Leu Gly Pro Glu Leu Ser 
    290                 295                 300                 
Lys Arg Leu Glu Thr Ala Ile Glu Ala Arg Glu Trp Phe Pro His Gly 
305                 310                 315                 320 
Phe Thr Thr Gly Gly His Pro Val Gly Cys Ala Ile Ala Leu Lys Ala 
                325                 330                 335     
Ile Asp Val Val Met Asn Glu Gly Leu Ala Glu Asn Val Arg Arg Leu 
            340                 345                 350         
Ala Pro Arg Phe Glu Glu Arg Leu Lys His Ile Ala Glu Arg Pro Asn 
        355                 360                 365             
Ile Gly Glu Tyr Arg Gly Ile Gly Phe Met Trp Ala Leu Glu Val Val 
    370                 375                 380                 
Lys Asp Lys Ala Ser Lys Ala Pro Phe Gly Gly Asn Leu Ser Val Ser 
385                 390                 395                 400 
Glu Arg Ile Ala Asn Thr Cys Thr Asp Leu Gly Leu Ile Val Arg Ala 
                405                 410                 415     
Leu Gly Gln Ser Val Ala Leu Cys Pro Pro Phe Ile Leu Thr Glu Val 
            420                 425                 430         
Gln Met Asp Glu Met Phe Asp Lys Leu Glu Lys Ala Leu Asp Lys Val 
        435                 440                 445             
Phe Ala Glu Val Ala                                             
    450                                                         

 
<210> 101
<211> 1359
<212> DNA
<213> Artificial Sequence
 
<220>
<223> variant of transaminase from Vibrio fluvialis Js17
 
<400> 101
atgaacaaac cgcagagctg ggaaacgcgt gcggaaacct atagcctgta tggttttacc 60
gatatgccga gcctgcatca gcgtggcacc gtggtggtga cccatggcga aggcccgtat 120
atcgtggatg tgcatggccg tcgttatctg gatgcgtgca gcggcgctgc gaacatggtg 180
gcgggctttg atcataaagg cctgattgat gcggcgaaaa cgcagtatga acgttttccg 240
ggctatcatg cggttaaagg ccgtatgagc gatcagaccg tgatgctgtc tgaaaaactg 300
gtggaagtga gcccgtttga tagcggccgt gtgttttata ccaacagcgg cagcgaagcg 360
aacgatacca tggtgaaaat gctgtggttt ctgcatgcgg cggaaggcaa accgcagaaa 420
cgtaaaattc tgacccattg gaacgcgtat catggcgcga ccgcggtgag cgcgagcatg 480
accggcatgc cgtataacag cgtgtttggc ctgccgctgc cgggctttct gcatctgacc 540
tgcccgcatt attggcgtta tggcgaagaa ggcgaaaccg aagaacagtt tgtcgcgcgt 600
ctggcccatg aactggaaga aaccattcag aaggaaggcg cggataccat tgcgggcttt 660
tttgcggaac cggtgatggg tgcgggcggt gttattccgc cggcaaaagg ctattttcag 720
gcgattctgc cgatcctgcg caaatatgat attccggtga tcagcgatga agtgatttgc 780
ggcttcggcc gtaccggtaa cacctggggc tgcgtgacct atgattttac cccggatgcg 840
attattagca gtaaaagcct aaccgcgggt ttttttgcgg taggcgcggt gattctgggt 900
ccggaactga gcaaacgtct ggaaaccgcg attgaagcgc gtgaatggtt tccgcatggt 960
tttaccacag gcggccatcc ggtgggttgt gcgattgcgc tgaaagcgat tgatgtggtg 1020
atgaacgaag gcctggccga aaacgtgcgt cgtctggccc cgcgttttga agaacgtctg 1080
aaacatattg cggaacgtcc gaacattggc gaatatcgtg gcattggctt tatgtgggcg 1140
ctggaagtcg tgaaagataa agcgagcaaa gccccgtttg gtggcaacct gagcgtgagc 1200
gaacgtattg cgaacacctg caccgatctg ggcctgattg tgcgtgcgct gggccagagc 1260
gtggcgctgt gcccgccgtt tattctgacc gaagcgcaga tggatgaaat gttcgataaa 1320
ctggaaaaag cgctggataa agtgttcgcg gaagtggcg                        1359

 
<210> 102
<211> 453
<212> PRT
<213> Artificial Sequence
 
<220>
<223> variant of transaminase from Vibrio fluvialis Js17
 
<400> 102
Met Asn Lys Pro Gln Ser Trp Glu Thr Arg Ala Glu Thr Tyr Ser Leu 
1               5                   10                  15      
Tyr Gly Phe Thr Asp Met Pro Ser Leu His Gln Arg Gly Thr Val Val 
            20                  25                  30          
Val Thr His Gly Glu Gly Pro Tyr Ile Val Asp Val His Gly Arg Arg 
        35                  40                  45              
Tyr Leu Asp Ala Cys Ser Gly Ala Ala Asn Met Val Ala Gly Phe Asp 
    50                  55                  60                  
His Lys Gly Leu Ile Asp Ala Ala Lys Thr Gln Tyr Glu Arg Phe Pro 
65                  70                  75                  80  
Gly Tyr His Ala Val Lys Gly Arg Met Ser Asp Gln Thr Val Met Leu 
                85                  90                  95      
Ser Glu Lys Leu Val Glu Val Ser Pro Phe Asp Ser Gly Arg Val Phe 
            100                 105                 110         
Tyr Thr Asn Ser Gly Ser Glu Ala Asn Asp Thr Met Val Lys Met Leu 
        115                 120                 125             
Trp Phe Leu His Ala Ala Glu Gly Lys Pro Gln Lys Arg Lys Ile Leu 
    130                 135                 140                 
Thr His Trp Asn Ala Tyr His Gly Ala Thr Ala Val Ser Ala Ser Met 
145                 150                 155                 160 
Thr Gly Met Pro Tyr Asn Ser Val Phe Gly Leu Pro Leu Pro Gly Phe 
                165                 170                 175     
Leu His Leu Thr Cys Pro His Tyr Trp Arg Tyr Gly Glu Glu Gly Glu 
            180                 185                 190         
Thr Glu Glu Gln Phe Val Ala Arg Leu Ala His Glu Leu Glu Glu Thr 
        195                 200                 205             
Ile Gln Lys Glu Gly Ala Asp Thr Ile Ala Gly Phe Phe Ala Glu Pro 
    210                 215                 220                 
Val Met Gly Ala Gly Gly Val Ile Pro Pro Ala Lys Gly Tyr Phe Gln 
225                 230                 235                 240 
Ala Ile Leu Pro Ile Leu Arg Lys Tyr Asp Ile Pro Val Ile Ser Asp 
                245                 250                 255     
Glu Val Ile Cys Gly Phe Gly Arg Thr Gly Asn Thr Trp Gly Cys Val 
            260                 265                 270         
Thr Tyr Asp Phe Thr Pro Asp Ala Ile Ile Ser Ser Lys Ser Leu Thr 
        275                 280                 285             
Ala Gly Phe Phe Ala Val Gly Ala Val Ile Leu Gly Pro Glu Leu Ser 
    290                 295                 300                 
Lys Arg Leu Glu Thr Ala Ile Glu Ala Arg Glu Trp Phe Pro His Gly 
305                 310                 315                 320 
Phe Thr Thr Gly Gly His Pro Val Gly Cys Ala Ile Ala Leu Lys Ala 
                325                 330                 335     
Ile Asp Val Val Met Asn Glu Gly Leu Ala Glu Asn Val Arg Arg Leu 
            340                 345                 350         
Ala Pro Arg Phe Glu Glu Arg Leu Lys His Ile Ala Glu Arg Pro Asn 
        355                 360                 365             
Ile Gly Glu Tyr Arg Gly Ile Gly Phe Met Trp Ala Leu Glu Val Val 
    370                 375                 380                 
Lys Asp Lys Ala Ser Lys Ala Pro Phe Gly Gly Asn Leu Ser Val Ser 
385                 390                 395                 400 
Glu Arg Ile Ala Asn Thr Cys Thr Asp Leu Gly Leu Ile Val Arg Ala 
                405                 410                 415     
Leu Gly Gln Ser Val Ala Leu Cys Pro Pro Phe Ile Leu Thr Glu Ala 
            420                 425                 430         
Gln Met Asp Glu Met Phe Asp Lys Leu Glu Lys Ala Leu Asp Lys Val 
        435                 440                 445             
Phe Ala Glu Val Ala                                             
    450                                                         

 
<210> 103
<211> 1359
<212> DNA
<213> Artificial Sequence
 
<220>
<223> variant of transaminase from Vibrio fluvialis Js17
 
<400> 103
atgaacaaac cgcagagctg ggaaacgcgt gcggaaacct atagcctgta tggttttacc 60
gatatgccga gcctgcatca gcgtggcacc gtggtggtga cccatggcga aggcccgtat 120
atcgtggatg tgcatggccg tcgttatctg gatgcgtgca gcggcgctgc gaacatggtg 180
gcgggctttg atcataaagg cctgattgat gcggcgaaaa cgcagtatga acgttttccg 240
ggctatcatg cggttaaagg ccgtatgagc gatcagaccg tgatgctgtc tgaaaaactg 300
gtggaagtga gcccgtttga tagcggccgt gtgttttata ccaacagcgg cagcgaagcg 360
aacgatacca tggtgaaaat gctgtggttt ctgcatgcgg cggaaggcaa accgcagaaa 420
cgtaaaattc tgacccattg gaacgcgtat catggcgcga ccgcggtgtg tgcgagcatg 480
accggctttc cgtataacag cgtgtttggc ctgccgctgc cgggctttct gcatctgacc 540
tgcccgcatt attggcgtta tggcgaagaa ggcgaaaccg aagaacagtt tgtcgcgcgt 600
ctggcccatg aactggaaga aaccattcag aaggaaggcg cggataccat tgcgggcttt 660
tttgcggaac cggtgatggg tgcgggcggt gttattccgc cggcaaaagg ctattttcag 720
gcgattctgc cgatcctgcg caaatatgat attccggtga tcagcgatga agtgatttgc 780
ggcttcggcc gtaccggtaa cacctggggc tgcgtgacct atgattttac cccggatgcg 840
attattagca gtaaaagcct aaccgcgggt ttttttgcgg taggcgcggt gattctgggt 900
ccggaactga gcaaacgtct ggaaaccgcg attgaagcgc gtgaatggtt tccgcatggt 960
tttaccacag gcggccatcc ggtgggttgt gcgattgcgc tgaaagcgat tgatgtggtg 1020
atgaacgaag gcctggccga aaacgtgcgt cgtctggccc cgcgttttga agaacgtctg 1080
aaacatattg cggaacgtcc gaacattggc gaatatcgtg gcattggctt tatgtgggcg 1140
ctggaagtcg tgaaagataa agcgagcaaa gccccgtttg gtggcaacct gagcgtgagc 1200
gaacgtattg cgaacacctg caccgatctg ggcctgattg tgcgtgcgct gggccagagc 1260
gtggcgctgt gcccgccgtt tattctgacc gaagcgcaga tggatgaaat gttcgataaa 1320
ctggaaaaag cgctggataa agtgttcgcg gaagtggcg                        1359

 
<210> 104
<211> 453
<212> PRT
<213> Artificial Sequence
 
<220>
<223> variant of transaminase from Vibrio fluvialis Js17
 
<400> 104
Met Asn Lys Pro Gln Ser Trp Glu Thr Arg Ala Glu Thr Tyr Ser Leu 
1               5                   10                  15      
Tyr Gly Phe Thr Asp Met Pro Ser Leu His Gln Arg Gly Thr Val Val 
            20                  25                  30          
Val Thr His Gly Glu Gly Pro Tyr Ile Val Asp Val His Gly Arg Arg 
        35                  40                  45              
Tyr Leu Asp Ala Cys Ser Gly Ala Ala Asn Met Val Ala Gly Phe Asp 
    50                  55                  60                  
His Lys Gly Leu Ile Asp Ala Ala Lys Thr Gln Tyr Glu Arg Phe Pro 
65                  70                  75                  80  
Gly Tyr His Ala Val Lys Gly Arg Met Ser Asp Gln Thr Val Met Leu 
                85                  90                  95      
Ser Glu Lys Leu Val Glu Val Ser Pro Phe Asp Ser Gly Arg Val Phe 
            100                 105                 110         
Tyr Thr Asn Ser Gly Ser Glu Ala Asn Asp Thr Met Val Lys Met Leu 
        115                 120                 125             
Trp Phe Leu His Ala Ala Glu Gly Lys Pro Gln Lys Arg Lys Ile Leu 
    130                 135                 140                 
Thr His Trp Asn Ala Tyr His Gly Ala Thr Ala Val Cys Ala Ser Met 
145                 150                 155                 160 
Thr Gly Phe Pro Tyr Asn Ser Val Phe Gly Leu Pro Leu Pro Gly Phe 
                165                 170                 175     
Leu His Leu Thr Cys Pro His Tyr Trp Arg Tyr Gly Glu Glu Gly Glu 
            180                 185                 190         
Thr Glu Glu Gln Phe Val Ala Arg Leu Ala His Glu Leu Glu Glu Thr 
        195                 200                 205             
Ile Gln Lys Glu Gly Ala Asp Thr Ile Ala Gly Phe Phe Ala Glu Pro 
    210                 215                 220                 
Val Met Gly Ala Gly Gly Val Ile Pro Pro Ala Lys Gly Tyr Phe Gln 
225                 230                 235                 240 
Ala Ile Leu Pro Ile Leu Arg Lys Tyr Asp Ile Pro Val Ile Ser Asp 
                245                 250                 255     
Glu Val Ile Cys Gly Phe Gly Arg Thr Gly Asn Thr Trp Gly Cys Val 
            260                 265                 270         
Thr Tyr Asp Phe Thr Pro Asp Ala Ile Ile Ser Ser Lys Ser Leu Thr 
        275                 280                 285             
Ala Gly Phe Phe Ala Val Gly Ala Val Ile Leu Gly Pro Glu Leu Ser 
    290                 295                 300                 
Lys Arg Leu Glu Thr Ala Ile Glu Ala Arg Glu Trp Phe Pro His Gly 
305                 310                 315                 320 
Phe Thr Thr Gly Gly His Pro Val Gly Cys Ala Ile Ala Leu Lys Ala 
                325                 330                 335     
Ile Asp Val Val Met Asn Glu Gly Leu Ala Glu Asn Val Arg Arg Leu 
            340                 345                 350         
Ala Pro Arg Phe Glu Glu Arg Leu Lys His Ile Ala Glu Arg Pro Asn 
        355                 360                 365             
Ile Gly Glu Tyr Arg Gly Ile Gly Phe Met Trp Ala Leu Glu Val Val 
    370                 375                 380                 
Lys Asp Lys Ala Ser Lys Ala Pro Phe Gly Gly Asn Leu Ser Val Ser 
385                 390                 395                 400 
Glu Arg Ile Ala Asn Thr Cys Thr Asp Leu Gly Leu Ile Val Arg Ala 
                405                 410                 415     
Leu Gly Gln Ser Val Ala Leu Cys Pro Pro Phe Ile Leu Thr Glu Ala 
            420                 425                 430         
Gln Met Asp Glu Met Phe Asp Lys Leu Glu Lys Ala Leu Asp Lys Val 
        435                 440                 445             
Phe Ala Glu Val Ala                                             
    450                                                         

 
<210> 105
<211> 1359
<212> DNA
<213> Artificial Sequence
 
<220>
<223> variant of transaminase from Vibrio fluvialis Js17
 
<400> 105
atgaacaaac cgcagagctg ggaaacgcgt gcggaaacct atagcctgta tggttttacc 60
gatatgccga gcctgcatca gcgtggcacc gtggtggtga cccatggcga aggcccgtat 120
atcgtggatg tgcatggccg tcgttatctg gatgcgtgca gcggcgctgc gaacatggtg 180
gcgggctttg atcataaagg cctgattgat gcggcgaaaa cgcagtatga acgttttccg 240
ggctatcatg cggttaaagg ccgtatgagc gatcagaccg tgatgctgtc tgaaaaactg 300
gtggaagtga gcccgtttga tagcggccgt gtgttttata ccaacagcgg cagcgaagcg 360
aacgatacca tggtgaaaat gctgtggttt ctgcatgcgg cggaaggcaa accgcagaaa 420
cgtaaaattc tgacccattg gaacgcgtat catggcgcga ccgcggtgag cgcgagcatg 480
accggctttc catataacag cgtgtttggc ctgccgctgc cgggctttct gcatctgacc 540
tgcccgcatt attggcgtta tggcgaagaa ggcgaaaccg aagaacagtt tgtcgcgcgt 600
ctggcccatg aactggaaga aaccattcag aaggaaggcg cggataccat tgcgggcttt 660
tttgcggaac cggtgatggg tgcgggcggt gttattccgc cggcaaaagg ctattttcag 720
gcgattctgc cgatcctgcg caaatatgat attccggtga tcagcgatga agtgatttgc 780
ggcttcggcc gtaccggtaa cacctggggc tgcgtgacct atgattttac cccggatgcg 840
attattagca gtaaaagcct aaccgcgggt ttttttgcgg taggcgcggt gattctgggt 900
ccggaactga gcaaacgtct ggaaaccgcg attgaagcgc gtgaatggtt tccgcatggt 960
tttaccacag gcggccatcc ggtgggttgt gcggttgcgc tgaaagcgat tgatgtggtg 1020
atgaacgaag gcctggccga aaacgtgcgt cgtctggccc cgcgttttga agaacgtctg 1080
aaacatattg cggaacgtcc gaacattggc gaatatcgtg gcattggctt tatgtgggcg 1140
ctggaagtcg tgaaagataa agcgagcaaa gccccgtttg gtggcaacct gagcgtgagc 1200
gaacgtattg cgaacacctg caccgatctg ggcctgattg tgcgtgcgct gggccagagc 1260
gtggcgctgt gcccgccgtt tattctgacc gaagcgcaga tggatgaaat gttcgataaa 1320
ctggaaaaag cgctggataa agtgttcgcg gaagtggcg                        1359

 
<210> 106
<211> 453
<212> PRT
<213> Artificial Sequence
 
<220>
<223> variant of transaminase from Vibrio fluvialis Js17
 
<400> 106
Met Asn Lys Pro Gln Ser Trp Glu Thr Arg Ala Glu Thr Tyr Ser Leu 
1               5                   10                  15      
Tyr Gly Phe Thr Asp Met Pro Ser Leu His Gln Arg Gly Thr Val Val 
            20                  25                  30          
Val Thr His Gly Glu Gly Pro Tyr Ile Val Asp Val His Gly Arg Arg 
        35                  40                  45              
Tyr Leu Asp Ala Cys Ser Gly Ala Ala Asn Met Val Ala Gly Phe Asp 
    50                  55                  60                  
His Lys Gly Leu Ile Asp Ala Ala Lys Thr Gln Tyr Glu Arg Phe Pro 
65                  70                  75                  80  
Gly Tyr His Ala Val Lys Gly Arg Met Ser Asp Gln Thr Val Met Leu 
                85                  90                  95      
Ser Glu Lys Leu Val Glu Val Ser Pro Phe Asp Ser Gly Arg Val Phe 
            100                 105                 110         
Tyr Thr Asn Ser Gly Ser Glu Ala Asn Asp Thr Met Val Lys Met Leu 
        115                 120                 125             
Trp Phe Leu His Ala Ala Glu Gly Lys Pro Gln Lys Arg Lys Ile Leu 
    130                 135                 140                 
Thr His Trp Asn Ala Tyr His Gly Ala Thr Ala Val Ser Ala Ser Met 
145                 150                 155                 160 
Thr Gly Phe Pro Tyr Asn Ser Val Phe Gly Leu Pro Leu Pro Gly Phe 
                165                 170                 175     
Leu His Leu Thr Cys Pro His Tyr Trp Arg Tyr Gly Glu Glu Gly Glu 
            180                 185                 190         
Thr Glu Glu Gln Phe Val Ala Arg Leu Ala His Glu Leu Glu Glu Thr 
        195                 200                 205             
Ile Gln Lys Glu Gly Ala Asp Thr Ile Ala Gly Phe Phe Ala Glu Pro 
    210                 215                 220                 
Val Met Gly Ala Gly Gly Val Ile Pro Pro Ala Lys Gly Tyr Phe Gln 
225                 230                 235                 240 
Ala Ile Leu Pro Ile Leu Arg Lys Tyr Asp Ile Pro Val Ile Ser Asp 
                245                 250                 255     
Glu Val Ile Cys Gly Phe Gly Arg Thr Gly Asn Thr Trp Gly Cys Val 
            260                 265                 270         
Thr Tyr Asp Phe Thr Pro Asp Ala Ile Ile Ser Ser Lys Ser Leu Thr 
        275                 280                 285             
Ala Gly Phe Phe Ala Val Gly Ala Val Ile Leu Gly Pro Glu Leu Ser 
    290                 295                 300                 
Lys Arg Leu Glu Thr Ala Ile Glu Ala Arg Glu Trp Phe Pro His Gly 
305                 310                 315                 320 
Phe Thr Thr Gly Gly His Pro Val Gly Cys Ala Val Ala Leu Lys Ala 
                325                 330                 335     
Ile Asp Val Val Met Asn Glu Gly Leu Ala Glu Asn Val Arg Arg Leu 
            340                 345                 350         
Ala Pro Arg Phe Glu Glu Arg Leu Lys His Ile Ala Glu Arg Pro Asn 
        355                 360                 365             
Ile Gly Glu Tyr Arg Gly Ile Gly Phe Met Trp Ala Leu Glu Val Val 
    370                 375                 380                 
Lys Asp Lys Ala Ser Lys Ala Pro Phe Gly Gly Asn Leu Ser Val Ser 
385                 390                 395                 400 
Glu Arg Ile Ala Asn Thr Cys Thr Asp Leu Gly Leu Ile Val Arg Ala 
                405                 410                 415     
Leu Gly Gln Ser Val Ala Leu Cys Pro Pro Phe Ile Leu Thr Glu Ala 
            420                 425                 430         
Gln Met Asp Glu Met Phe Asp Lys Leu Glu Lys Ala Leu Asp Lys Val 
        435                 440                 445             
Phe Ala Glu Val Ala                                             
    450                                                         

 
<210> 107
<211> 1359
<212> DNA
<213> Artificial Sequence
 
<220>
<223> variant of transaminase from Vibrio fluvialis Js17
 
<400> 107
atgaacaaac cgcagagctg ggaaacgcgt gcggaaacct atagcctgta tggttttacc 60
gatatgccga gcctgcatca gcgtggcacc gtggtggtga cccatggcga aggcccgtat 120
atcgtggatg tgcatggccg tcgttatctg gatgcgtgca gcggcgctgc gaacatggtg 180
gcgggctttg atcataaagg cctgattgat gcggcgaaaa cgcagtatga acgttttccg 240
ggctatcatg cggttaaagg ccgtatgagc gatcagaccg tgatgctgtc tgaaaaactg 300
gtggaagtga gcccgtttga tagcggccgt gtgttttata ccaacagcgg cagcgaagcg 360
aacgatacca tggtgaaaat gctgtggttt ctgcatgcgg cggaaggcaa accgcagaaa 420
cgtaaaattc tgacccattg gaacgcgtat catggcgcga ccgcggtggc ggcgagcatg 480
accggctttc cgtataacag cgtgtttggc ctgccgctgc cgggctttct gcatctgacc 540
tgcccgcatt attggcgtta tggcgaagaa ggcgaaaccg aagaacagtt tgtcgcgcgt 600
ctggcccatg aactggaaga aaccattcag aaggaaggcg cggataccat tgcgggcttt 660
tttgcggaac cggtgatggg tgcgggcggt gttattccgc cggcaaaagg ctattttcag 720
gcgattctgc cgatcctgcg caaatatgat attccggtga tcagcgatga agtgatttgc 780
ggcttcggcc gtaccggtaa cacctggggc tgcgtgacct atgattttac cccggatgcg 840
attattagca gtaaaagcct aaccgcgggt ttttttgcgg taggcgcggt gattctgggt 900
ccggaactga gcaaacgtct ggaaaccgcg attgaagcgc gtgaatggtt tccgcatggt 960
tttaccacag gcggccatcc ggtgggttgt gcgattgcgc tgaaagcgat tgatgtggtg 1020
atgaacgaag gcctggccga aaacgtgcgt cgtctggccc cgcgttttga agaacgtctg 1080
aaacatattg cggaacgtcc gaacattggc gaatatcgtg gcattggctt tatgtgggcg 1140
ctggaagtcg tgaaagataa agcgagcaaa gccccgtttg gtggcaacct gagcgtgagc 1200
gaacgtattg cgaacacctg caccgatctg ggcctgattg tgcgtgcgct gggccagagc 1260
gtggcgctgt gcccgccgtt tattctgacc gaagcgcaga tggatgaaat gttcgataaa 1320
ctggaaaaag cgctggataa agtgttcgcg gaagtggcg                        1359

 
<210> 108
<211> 453
<212> PRT
<213> Artificial Sequence
 
<220>
<223> variant of transaminase from Vibrio fluvialis Js17
 
<400> 108
Met Asn Lys Pro Gln Ser Trp Glu Thr Arg Ala Glu Thr Tyr Ser Leu 
1               5                   10                  15      
Tyr Gly Phe Thr Asp Met Pro Ser Leu His Gln Arg Gly Thr Val Val 
            20                  25                  30          
Val Thr His Gly Glu Gly Pro Tyr Ile Val Asp Val His Gly Arg Arg 
        35                  40                  45              
Tyr Leu Asp Ala Cys Ser Gly Ala Ala Asn Met Val Ala Gly Phe Asp 
    50                  55                  60                  
His Lys Gly Leu Ile Asp Ala Ala Lys Thr Gln Tyr Glu Arg Phe Pro 
65                  70                  75                  80  
Gly Tyr His Ala Val Lys Gly Arg Met Ser Asp Gln Thr Val Met Leu 
                85                  90                  95      
Ser Glu Lys Leu Val Glu Val Ser Pro Phe Asp Ser Gly Arg Val Phe 
            100                 105                 110         
Tyr Thr Asn Ser Gly Ser Glu Ala Asn Asp Thr Met Val Lys Met Leu 
        115                 120                 125             
Trp Phe Leu His Ala Ala Glu Gly Lys Pro Gln Lys Arg Lys Ile Leu 
    130                 135                 140                 
Thr His Trp Asn Ala Tyr His Gly Ala Thr Ala Val Ala Ala Ser Met 
145                 150                 155                 160 
Thr Gly Phe Pro Tyr Asn Ser Val Phe Gly Leu Pro Leu Pro Gly Phe 
                165                 170                 175     
Leu His Leu Thr Cys Pro His Tyr Trp Arg Tyr Gly Glu Glu Gly Glu 
            180                 185                 190         
Thr Glu Glu Gln Phe Val Ala Arg Leu Ala His Glu Leu Glu Glu Thr 
        195                 200                 205             
Ile Gln Lys Glu Gly Ala Asp Thr Ile Ala Gly Phe Phe Ala Glu Pro 
    210                 215                 220                 
Val Met Gly Ala Gly Gly Val Ile Pro Pro Ala Lys Gly Tyr Phe Gln 
225                 230                 235                 240 
Ala Ile Leu Pro Ile Leu Arg Lys Tyr Asp Ile Pro Val Ile Ser Asp 
                245                 250                 255     
Glu Val Ile Cys Gly Phe Gly Arg Thr Gly Asn Thr Trp Gly Cys Val 
            260                 265                 270         
Thr Tyr Asp Phe Thr Pro Asp Ala Ile Ile Ser Ser Lys Ser Leu Thr 
        275                 280                 285             
Ala Gly Phe Phe Ala Val Gly Ala Val Ile Leu Gly Pro Glu Leu Ser 
    290                 295                 300                 
Lys Arg Leu Glu Thr Ala Ile Glu Ala Arg Glu Trp Phe Pro His Gly 
305                 310                 315                 320 
Phe Thr Thr Gly Gly His Pro Val Gly Cys Ala Ile Ala Leu Lys Ala 
                325                 330                 335     
Ile Asp Val Val Met Asn Glu Gly Leu Ala Glu Asn Val Arg Arg Leu 
            340                 345                 350         
Ala Pro Arg Phe Glu Glu Arg Leu Lys His Ile Ala Glu Arg Pro Asn 
        355                 360                 365             
Ile Gly Glu Tyr Arg Gly Ile Gly Phe Met Trp Ala Leu Glu Val Val 
    370                 375                 380                 
Lys Asp Lys Ala Ser Lys Ala Pro Phe Gly Gly Asn Leu Ser Val Ser 
385                 390                 395                 400 
Glu Arg Ile Ala Asn Thr Cys Thr Asp Leu Gly Leu Ile Val Arg Ala 
                405                 410                 415     
Leu Gly Gln Ser Val Ala Leu Cys Pro Pro Phe Ile Leu Thr Glu Ala 
            420                 425                 430         
Gln Met Asp Glu Met Phe Asp Lys Leu Glu Lys Ala Leu Asp Lys Val 
        435                 440                 445             
Phe Ala Glu Val Ala                                             
    450                                                         

 
<210> 109
<211> 1359
<212> DNA
<213> Artificial Sequence
 
<220>
<223> variant of transaminase from Vibrio fluvialis Js17
 
<400> 109
atgaacaaac cgcagagctg ggaaacgcgt gcggaaacct atagcctgta tggttttacc 60
gatatgccga gcctgcatca gcgtggcacc gtggtggtga cccatggcga aggcccgtat 120
atcgtggatg tgcatggccg tcgttatctg gatgcgtgca gcggcgctgc gaacatggtg 180
gcgggctttg atcataaagg cctgattgat gcggcgaaaa cgcagtatga acgttttccg 240
ggctatcatg cggttaaagg ccgtatgagc gatcagaccg tgatgctgtc tgaaaaactg 300
gtggaagtga gcccgtttga tagcggccgt gtgttttata ccaacagcgg cagcgaagcg 360
aacgatacca tggtgaaaat gctgtggttt ctgcatgcgg cggaaggcaa accgcagaaa 420
cgtaaaattc tgacccattg gaacgcgtat catggcgcga ccgcggtgag cgcgagcatg 480
accggctttc cgtataacag cgtgtttggc ctgccgctgc cgggctttct gcatctgacc 540
tgcccgcatt attggcgtta tggcgaagaa ggcgaaaccg aagaacagtt tgtcgcgcgt 600
ctggcccatg aactggaaga aaccattcag aaggaaggcg cggataccat tgcgggcttt 660
tttgcggaac cggtgatggg tgcgggcggt gttattccgc cggcaaaagg ctattttcag 720
gcgattctgc cgatcctgcg caaatatgat attccggtga tcagcgatga agtgatttgc 780
ggcttcggcc gtaccggtaa cacctggggc tgcgtgacct atgattttac cccggatgcg 840
attattagcg cgaaaagcct aaccgcgggt ttttttgcgg taggcgcggt gattctgggt 900
ccggaactga gcaaacgtct ggaaaccgcg attgaagcgc gtgaatggtt tccgcatggt 960
tttaccacag gcggccatcc ggtgggttgt gcgattgcgc tgaaagcgat tgatgtggtg 1020
atgaacgaag gcctggccga aaacgtgcgt cgtctggccc cgcgttttga agaacgtctg 1080
aaacatattg cggaacgtcc gaacattggc gaatatcgtg gcattggctt tatgtgggcg 1140
ctggaagtcg tgaaagataa agcgagcaaa gccccgtttg gtggcaacct gagcgtgagc 1200
gaacgtattg cgaacacctg caccgatctg ggcctgattg tgcgtgcgct gggccagagc 1260
gtggcgctgt gcccgccgtt tattctgacc gaagcgcaga tggatgaaat gttcgataaa 1320
ctggaaaaag cgctggataa agtgttcgcg gaagtggcg                        1359

 
<210> 110
<211> 453
<212> PRT
<213> Artificial Sequence
 
<220>
<223> variant of transaminase from Vibrio fluvialis Js17
 
<400> 110
Met Asn Lys Pro Gln Ser Trp Glu Thr Arg Ala Glu Thr Tyr Ser Leu 
1               5                   10                  15      
Tyr Gly Phe Thr Asp Met Pro Ser Leu His Gln Arg Gly Thr Val Val 
            20                  25                  30          
Val Thr His Gly Glu Gly Pro Tyr Ile Val Asp Val His Gly Arg Arg 
        35                  40                  45              
Tyr Leu Asp Ala Cys Ser Gly Ala Ala Asn Met Val Ala Gly Phe Asp 
    50                  55                  60                  
His Lys Gly Leu Ile Asp Ala Ala Lys Thr Gln Tyr Glu Arg Phe Pro 
65                  70                  75                  80  
Gly Tyr His Ala Val Lys Gly Arg Met Ser Asp Gln Thr Val Met Leu 
                85                  90                  95      
Ser Glu Lys Leu Val Glu Val Ser Pro Phe Asp Ser Gly Arg Val Phe 
            100                 105                 110         
Tyr Thr Asn Ser Gly Ser Glu Ala Asn Asp Thr Met Val Lys Met Leu 
        115                 120                 125             
Trp Phe Leu His Ala Ala Glu Gly Lys Pro Gln Lys Arg Lys Ile Leu 
    130                 135                 140                 
Thr His Trp Asn Ala Tyr His Gly Ala Thr Ala Val Ser Ala Ser Met 
145                 150                 155                 160 
Thr Gly Phe Pro Tyr Asn Ser Val Phe Gly Leu Pro Leu Pro Gly Phe 
                165                 170                 175     
Leu His Leu Thr Cys Pro His Tyr Trp Arg Tyr Gly Glu Glu Gly Glu 
            180                 185                 190         
Thr Glu Glu Gln Phe Val Ala Arg Leu Ala His Glu Leu Glu Glu Thr 
        195                 200                 205             
Ile Gln Lys Glu Gly Ala Asp Thr Ile Ala Gly Phe Phe Ala Glu Pro 
    210                 215                 220                 
Val Met Gly Ala Gly Gly Val Ile Pro Pro Ala Lys Gly Tyr Phe Gln 
225                 230                 235                 240 
Ala Ile Leu Pro Ile Leu Arg Lys Tyr Asp Ile Pro Val Ile Ser Asp 
                245                 250                 255     
Glu Val Ile Cys Gly Phe Gly Arg Thr Gly Asn Thr Trp Gly Cys Val 
            260                 265                 270         
Thr Tyr Asp Phe Thr Pro Asp Ala Ile Ile Ser Ala Lys Ser Leu Thr 
        275                 280                 285             
Ala Gly Phe Phe Ala Val Gly Ala Val Ile Leu Gly Pro Glu Leu Ser 
    290                 295                 300                 
Lys Arg Leu Glu Thr Ala Ile Glu Ala Arg Glu Trp Phe Pro His Gly 
305                 310                 315                 320 
Phe Thr Thr Gly Gly His Pro Val Gly Cys Ala Ile Ala Leu Lys Ala 
                325                 330                 335     
Ile Asp Val Val Met Asn Glu Gly Leu Ala Glu Asn Val Arg Arg Leu 
            340                 345                 350         
Ala Pro Arg Phe Glu Glu Arg Leu Lys His Ile Ala Glu Arg Pro Asn 
        355                 360                 365             
Ile Gly Glu Tyr Arg Gly Ile Gly Phe Met Trp Ala Leu Glu Val Val 
    370                 375                 380                 
Lys Asp Lys Ala Ser Lys Ala Pro Phe Gly Gly Asn Leu Ser Val Ser 
385                 390                 395                 400 
Glu Arg Ile Ala Asn Thr Cys Thr Asp Leu Gly Leu Ile Val Arg Ala 
                405                 410                 415     
Leu Gly Gln Ser Val Ala Leu Cys Pro Pro Phe Ile Leu Thr Glu Ala 
            420                 425                 430         
Gln Met Asp Glu Met Phe Asp Lys Leu Glu Lys Ala Leu Asp Lys Val 
        435                 440                 445             
Phe Ala Glu Val Ala                                             
    450                                                         

 
<210> 111
<211> 1359
<212> DNA
<213> Artificial Sequence
 
<220>
<223> variant of transaminase from Vibrio fluvialis Js17
 
<400> 111
atgaacaaac cgcagagctg ggaaacgcgt gcggaaacct atagcctgta tggttttacc 60
gatatgccga gcctgcatca gcgtggcacc atggtggtga cccatggcga aggcccgtat 120
atcgtggatg tgcatggccg tcgttatctg gatgcgtgca gcggcgctgc gaacatggtg 180
gcgggctttg atcataaagg cctgattgat gcggcgaaaa cgcagtatga acgttttccg 240
ggctatcatg cggttaaagg ccgtatgagc gatcagaccg tgatgctgtc tgaaaaactg 300
gtggaagtga gcccgtttga tagcggccgt gtgttttata ccaacagcgg cagcgaagcg 360
aacgatacca tggtgaaaat gctgtggttt ctgcatgcgg cggaaggcaa accgcagaaa 420
cgtaaaattc tgacccattg gaacgcgtat catggcgcga ccgcggtgag cgcgagcatg 480
accggctttc cgtataacag cgtgtttggc ctgccgctgc cgggctttct gcatctgacc 540
tgcccgcatt attggcgtta tggcgaagaa ggcgaaaccg aagaacagtt tgtcgcgcgt 600
ctggcccatg aactggaaga aaccattcag aaggaaggcg cggataccat tgcgggcttt 660
tttgcggaac cggtgatggg tgcgggcggt gttattccgc cggcaaaagg ctattttcag 720
gcgattctgc cgatcctgcg caaatatgat attccggtga tcagcgatga agtgattacc 780
ggcttcggcc gtaccggtaa cacctggggc tgcgtgacct atgattttac cccggatgcg 840
attattagcg cgaaaggcct aaccgcgggt ttttttgcgg taggcgcggt gattctgggt 900
ccggaactga gcaaacgtct ggaaaccgcg attgaactgc gtgaatggtt tccgcatggt 960
tttaccacag gcggccatcc ggtgggttgt gcgattgcgc tgaaagcgat tgatgtggtg 1020
atgaacgaag gcctggccga aaacgtgcgt cgtctggccc cgcgttttga agaacgtctg 1080
aaacatattg cggaacgtcc gaacattggc gaatatcgtg gcattggctt tatgtgggcg 1140
ctggaagtcg tgaaagataa agcgagcaaa gccccgtttg gtggcaacct gagcgtgagc 1200
gaacgtattg cgaacacctg caccgatctg ggcctgattg tgcgtgcgct gggccagagc 1260
gtggcgctgg cgccgccgtt tattctgacc gaagcgcaga tggatgaaat gttcgataaa 1320
ctggaaaaag cgctggataa agtgttcgcg gaagtggcg                        1359

 
<210> 112
<211> 453
<212> PRT
<213> Artificial Sequence
 
<220>
<223> variant of transaminase from Vibrio fluvialis Js17
 
<400> 112
Met Asn Lys Pro Gln Ser Trp Glu Thr Arg Ala Glu Thr Tyr Ser Leu 
1               5                   10                  15      
Tyr Gly Phe Thr Asp Met Pro Ser Leu His Gln Arg Gly Thr Met Val 
            20                  25                  30          
Val Thr His Gly Glu Gly Pro Tyr Ile Val Asp Val His Gly Arg Arg 
        35                  40                  45              
Tyr Leu Asp Ala Cys Ser Gly Ala Ala Asn Met Val Ala Gly Phe Asp 
    50                  55                  60                  
His Lys Gly Leu Ile Asp Ala Ala Lys Thr Gln Tyr Glu Arg Phe Pro 
65                  70                  75                  80  
Gly Tyr His Ala Val Lys Gly Arg Met Ser Asp Gln Thr Val Met Leu 
                85                  90                  95      
Ser Glu Lys Leu Val Glu Val Ser Pro Phe Asp Ser Gly Arg Val Phe 
            100                 105                 110         
Tyr Thr Asn Ser Gly Ser Glu Ala Asn Asp Thr Met Val Lys Met Leu 
        115                 120                 125             
Trp Phe Leu His Ala Ala Glu Gly Lys Pro Gln Lys Arg Lys Ile Leu 
    130                 135                 140                 
Thr His Trp Asn Ala Tyr His Gly Ala Thr Ala Val Ser Ala Ser Met 
145                 150                 155                 160 
Thr Gly Phe Pro Tyr Asn Ser Val Phe Gly Leu Pro Leu Pro Gly Phe 
                165                 170                 175     
Leu His Leu Thr Cys Pro His Tyr Trp Arg Tyr Gly Glu Glu Gly Glu 
            180                 185                 190         
Thr Glu Glu Gln Phe Val Ala Arg Leu Ala His Glu Leu Glu Glu Thr 
        195                 200                 205             
Ile Gln Lys Glu Gly Ala Asp Thr Ile Ala Gly Phe Phe Ala Glu Pro 
    210                 215                 220                 
Val Met Gly Ala Gly Gly Val Ile Pro Pro Ala Lys Gly Tyr Phe Gln 
225                 230                 235                 240 
Ala Ile Leu Pro Ile Leu Arg Lys Tyr Asp Ile Pro Val Ile Ser Asp 
                245                 250                 255     
Glu Val Ile Thr Gly Phe Gly Arg Thr Gly Asn Thr Trp Gly Cys Val 
            260                 265                 270         
Thr Tyr Asp Phe Thr Pro Asp Ala Ile Ile Ser Ala Lys Gly Leu Thr 
        275                 280                 285             
Ala Gly Phe Phe Ala Val Gly Ala Val Ile Leu Gly Pro Glu Leu Ser 
    290                 295                 300                 
Lys Arg Leu Glu Thr Ala Ile Glu Leu Arg Glu Trp Phe Pro His Gly 
305                 310                 315                 320 
Phe Thr Thr Gly Gly His Pro Val Gly Cys Ala Ile Ala Leu Lys Ala 
                325                 330                 335     
Ile Asp Val Val Met Asn Glu Gly Leu Ala Glu Asn Val Arg Arg Leu 
            340                 345                 350         
Ala Pro Arg Phe Glu Glu Arg Leu Lys His Ile Ala Glu Arg Pro Asn 
        355                 360                 365             
Ile Gly Glu Tyr Arg Gly Ile Gly Phe Met Trp Ala Leu Glu Val Val 
    370                 375                 380                 
Lys Asp Lys Ala Ser Lys Ala Pro Phe Gly Gly Asn Leu Ser Val Ser 
385                 390                 395                 400 
Glu Arg Ile Ala Asn Thr Cys Thr Asp Leu Gly Leu Ile Val Arg Ala 
                405                 410                 415     
Leu Gly Gln Ser Val Ala Leu Ala Pro Pro Phe Ile Leu Thr Glu Ala 
            420                 425                 430         
Gln Met Asp Glu Met Phe Asp Lys Leu Glu Lys Ala Leu Asp Lys Val 
        435                 440                 445             
Phe Ala Glu Val Ala                                             
    450                                                         

 
<210> 113
<211> 1359
<212> DNA
<213> Artificial Sequence
 
<220>
<223> variant of transaminase from Vibrio fluvialis Js17
 
<400> 113
atgaacaaac cgcagagctg ggaaacgcgt gcggaaacct atagcctgta tggttttacc 60
gatatgccga gcctgcatca gcgtggcacc atggtggtga cccatggcga aggcccgtat 120
atcgtggatg tgcatggccg tcgttatctg gatgcgtgca gcggcgctgc gaacatggtg 180
gcgggctttg atcataaagg cctgattgat gcggcgaaaa cgcagtatga acgttttccg 240
ggctatcatg cggttaaagg ccgtatgagc gatcagaccg tgatgctgtc tgaaaaactg 300
gtggaagtga gcccgtttga tagcggccgt gtgttttata ccaacagcgg cagcgaagcg 360
aacgatacca tggtgaaaat gctgtggttt ctgcatgcgg cggaaggcaa accgcagaaa 420
cgtaaaattc tgacccattg gaacgcgtat catggcgcga ccgcggtgag cgcgagcatg 480
accggctttc cgtataacag cgtgtttggc ctgccgctgc cgggctttct gcatctgacc 540
tgcccgcatt attggcgtta tggcgaagaa ggcgaaaccg aagaacagtt tgtcgcgcgt 600
ctggcccatg aactggaaga aaacattcag aaggaaggcg cggataccat tgcgggcttt 660
tttgcggaac cggtgatggg tgcgggcggt gttattccgc cggcaaaagg ctattttcag 720
gcgattctgc cgatcctgcg caaatatgat attccggtga tcagcgatga agtgattacc 780
ggcttcggcc gtaccggtaa cacctggggc tgcgtgacct atgattttac cccggatgcg 840
attattagcg cgaaaggcct aaccgcgggt ttttttgcgg cgggcgcggt gattctgggt 900
ccggaactga gcaaacgtct ggaaaccgcg attgaagagc gtgaatggtt tccgcatggt 960
tttaccacag gcggccatcc ggtgggttgt gcgattgcgc tgaaagcgat tgatgtggtg 1020
atgaacgaag gcctggccga aaacgtgcgt cgtctggccc cgcgttttga agaacgtctg 1080
aaacatattg cggaacgtcc gaacattggc gaatatcgtg gcattggctt tatgtgggcg 1140
ctggaagtcg tgaaagataa agcgagcaaa gccccgtttg gtggcaacct gagcgtgagc 1200
gaacgtattg cgaacacctg caccgatctg ggcctgattg tgcgtgcgct gggccagagc 1260
gtggcgctgg cgccgccgtt tattctgacc gaagcgcaga tggatgaaat gttcgataaa 1320
ctggaaaaag cgctggataa agtgttcgcg gaagtggcg                        1359

 
<210> 114
<211> 453
<212> PRT
<213> Artificial Sequence
 
<220>
<223> variant of transaminase from Vibrio fluvialis Js17
 
<400> 114
Met Asn Lys Pro Gln Ser Trp Glu Thr Arg Ala Glu Thr Tyr Ser Leu 
1               5                   10                  15      
Tyr Gly Phe Thr Asp Met Pro Ser Leu His Gln Arg Gly Thr Met Val 
            20                  25                  30          
Val Thr His Gly Glu Gly Pro Tyr Ile Val Asp Val His Gly Arg Arg 
        35                  40                  45              
Tyr Leu Asp Ala Cys Ser Gly Ala Ala Asn Met Val Ala Gly Phe Asp 
    50                  55                  60                  
His Lys Gly Leu Ile Asp Ala Ala Lys Thr Gln Tyr Glu Arg Phe Pro 
65                  70                  75                  80  
Gly Tyr His Ala Val Lys Gly Arg Met Ser Asp Gln Thr Val Met Leu 
                85                  90                  95      
Ser Glu Lys Leu Val Glu Val Ser Pro Phe Asp Ser Gly Arg Val Phe 
            100                 105                 110         
Tyr Thr Asn Ser Gly Ser Glu Ala Asn Asp Thr Met Val Lys Met Leu 
        115                 120                 125             
Trp Phe Leu His Ala Ala Glu Gly Lys Pro Gln Lys Arg Lys Ile Leu 
    130                 135                 140                 
Thr His Trp Asn Ala Tyr His Gly Ala Thr Ala Val Ser Ala Ser Met 
145                 150                 155                 160 
Thr Gly Phe Pro Tyr Asn Ser Val Phe Gly Leu Pro Leu Pro Gly Phe 
                165                 170                 175     
Leu His Leu Thr Cys Pro His Tyr Trp Arg Tyr Gly Glu Glu Gly Glu 
            180                 185                 190         
Thr Glu Glu Gln Phe Val Ala Arg Leu Ala His Glu Leu Glu Glu Asn 
        195                 200                 205             
Ile Gln Lys Glu Gly Ala Asp Thr Ile Ala Gly Phe Phe Ala Glu Pro 
    210                 215                 220                 
Val Met Gly Ala Gly Gly Val Ile Pro Pro Ala Lys Gly Tyr Phe Gln 
225                 230                 235                 240 
Ala Ile Leu Pro Ile Leu Arg Lys Tyr Asp Ile Pro Val Ile Ser Asp 
                245                 250                 255     
Glu Val Ile Thr Gly Phe Gly Arg Thr Gly Asn Thr Trp Gly Cys Val 
            260                 265                 270         
Thr Tyr Asp Phe Thr Pro Asp Ala Ile Ile Ser Ala Lys Gly Leu Thr 
        275                 280                 285             
Ala Gly Phe Phe Ala Ala Gly Ala Val Ile Leu Gly Pro Glu Leu Ser 
    290                 295                 300                 
Lys Arg Leu Glu Thr Ala Ile Glu Glu Arg Glu Trp Phe Pro His Gly 
305                 310                 315                 320 
Phe Thr Thr Gly Gly His Pro Val Gly Cys Ala Ile Ala Leu Lys Ala 
                325                 330                 335     
Ile Asp Val Val Met Asn Glu Gly Leu Ala Glu Asn Val Arg Arg Leu 
            340                 345                 350         
Ala Pro Arg Phe Glu Glu Arg Leu Lys His Ile Ala Glu Arg Pro Asn 
        355                 360                 365             
Ile Gly Glu Tyr Arg Gly Ile Gly Phe Met Trp Ala Leu Glu Val Val 
    370                 375                 380                 
Lys Asp Lys Ala Ser Lys Ala Pro Phe Gly Gly Asn Leu Ser Val Ser 
385                 390                 395                 400 
Glu Arg Ile Ala Asn Thr Cys Thr Asp Leu Gly Leu Ile Val Arg Ala 
                405                 410                 415     
Leu Gly Gln Ser Val Ala Leu Ala Pro Pro Phe Ile Leu Thr Glu Ala 
            420                 425                 430         
Gln Met Asp Glu Met Phe Asp Lys Leu Glu Lys Ala Leu Asp Lys Val 
        435                 440                 445             
Phe Ala Glu Val Ala                                             
    450                                                         

 
<210> 115
<211> 1359
<212> DNA
<213> Artificial Sequence
 
<220>
<223> variant of transaminase from Vibrio fluvialis Js17
 
<400> 115
atgaacaaac cgcagagctg ggaaacgcgt gcggaaacct atagcctgta tggttttacc 60
gatatgccga gcctgcatca gcgtggcacc atggtggtga cccatggcga aggcccgtat 120
atcgtggatg tgcatggccg tcgttatctg gatgcgtgca gcggcgctgc gaacatggtg 180
gcgggctttg atcataaagg cctgattgat gcggcgaaaa cgcagtatga acgttttccg 240
ggctatcatg cggttaaagg ccgtatgagc gatcagaccg tgatgctgtc tgaaaaactg 300
gtggaagtga gcccgtttga tagcggccgt gtgttttata ccaacagcgg cagcgaagcg 360
aacgatacca tggtgaaaat gctgtggttt ctgcatgcgg cggaaggcaa accgcagaaa 420
cgtaaaattc tgacccattg gaacgcgtat catggcgcga ccgcggtgag cgcgagcatg 480
accggctttc cgtataacag cgtgtttggc ctgccgctgc cgggctttct gcatctgacc 540
tgcccgcatt attggcgtta tggcgaagaa ggcgaaaccg aagaacagtt tgtcgcgcgt 600
ctggcccatg aactggaaga aaacattcag aaggaaggcg cggataccat tgcgggcttt 660
tttgcggaac cggtgatggg tgcgggcggt gttattccgc cggcaaaagg ctattttcag 720
gcgattctgc cgatcctgcg caaatatgat attccggtga tcagcgatga agtgattacc 780
ggcttcggcc gtaccggtaa cacctggggc tgcgtgacct atgattttac cccggatgcg 840
attattagcg cgaaaggcct aaccgcgggt ttttttgcgg cgggcgcggt gattctgggt 900
ccggaactga gcaaacgtct ggaaaccgcg attgaactgc gtgaatggtt tccgcatggt 960
tttaccacag gcggccatcc ggtgggttgt gcgattgcgc tgaaagcgat tgatgtggtg 1020
atgaacgaag gcctggccga aaacgtgcgt cgtctggccc cgcgttttga agaacgtctg 1080
aaacatattg cggaacgtcc gaacattggc gaatatcgtg gcattggctt tatgtgggcg 1140
ctggaagtcg tgaaagataa agcgagcaaa gccccgtttg gtggcaacct gagcgtgagc 1200
gaacgtattg cgaacacctg caccgatctg ggcctgattg tgcgtgcgct gggccagagc 1260
gtggcgctgg cgccgccgtt tattctgacc gaagcgcaga tggatgaaat gttcgataaa 1320
ctggaaaaag cgctggataa agtgttcgcg gaagtggcg                        1359

 
<210> 116
<211> 453
<212> PRT
<213> Artificial Sequence
 
<220>
<223> variant of transaminase from Vibrio fluvialis Js17
 
<400> 116
Met Asn Lys Pro Gln Ser Trp Glu Thr Arg Ala Glu Thr Tyr Ser Leu 
1               5                   10                  15      
Tyr Gly Phe Thr Asp Met Pro Ser Leu His Gln Arg Gly Thr Met Val 
            20                  25                  30          
Val Thr His Gly Glu Gly Pro Tyr Ile Val Asp Val His Gly Arg Arg 
        35                  40                  45              
Tyr Leu Asp Ala Cys Ser Gly Ala Ala Asn Met Val Ala Gly Phe Asp 
    50                  55                  60                  
His Lys Gly Leu Ile Asp Ala Ala Lys Thr Gln Tyr Glu Arg Phe Pro 
65                  70                  75                  80  
Gly Tyr His Ala Val Lys Gly Arg Met Ser Asp Gln Thr Val Met Leu 
                85                  90                  95      
Ser Glu Lys Leu Val Glu Val Ser Pro Phe Asp Ser Gly Arg Val Phe 
            100                 105                 110         
Tyr Thr Asn Ser Gly Ser Glu Ala Asn Asp Thr Met Val Lys Met Leu 
        115                 120                 125             
Trp Phe Leu His Ala Ala Glu Gly Lys Pro Gln Lys Arg Lys Ile Leu 
    130                 135                 140                 
Thr His Trp Asn Ala Tyr His Gly Ala Thr Ala Val Ser Ala Ser Met 
145                 150                 155                 160 
Thr Gly Phe Pro Tyr Asn Ser Val Phe Gly Leu Pro Leu Pro Gly Phe 
                165                 170                 175     
Leu His Leu Thr Cys Pro His Tyr Trp Arg Tyr Gly Glu Glu Gly Glu 
            180                 185                 190         
Thr Glu Glu Gln Phe Val Ala Arg Leu Ala His Glu Leu Glu Glu Asn 
        195                 200                 205             
Ile Gln Lys Glu Gly Ala Asp Thr Ile Ala Gly Phe Phe Ala Glu Pro 
    210                 215                 220                 
Val Met Gly Ala Gly Gly Val Ile Pro Pro Ala Lys Gly Tyr Phe Gln 
225                 230                 235                 240 
Ala Ile Leu Pro Ile Leu Arg Lys Tyr Asp Ile Pro Val Ile Ser Asp 
                245                 250                 255     
Glu Val Ile Thr Gly Phe Gly Arg Thr Gly Asn Thr Trp Gly Cys Val 
            260                 265                 270         
Thr Tyr Asp Phe Thr Pro Asp Ala Ile Ile Ser Ala Lys Gly Leu Thr 
        275                 280                 285             
Ala Gly Phe Phe Ala Ala Gly Ala Val Ile Leu Gly Pro Glu Leu Ser 
    290                 295                 300                 
Lys Arg Leu Glu Thr Ala Ile Glu Leu Arg Glu Trp Phe Pro His Gly 
305                 310                 315                 320 
Phe Thr Thr Gly Gly His Pro Val Gly Cys Ala Ile Ala Leu Lys Ala 
                325                 330                 335     
Ile Asp Val Val Met Asn Glu Gly Leu Ala Glu Asn Val Arg Arg Leu 
            340                 345                 350         
Ala Pro Arg Phe Glu Glu Arg Leu Lys His Ile Ala Glu Arg Pro Asn 
        355                 360                 365             
Ile Gly Glu Tyr Arg Gly Ile Gly Phe Met Trp Ala Leu Glu Val Val 
    370                 375                 380                 
Lys Asp Lys Ala Ser Lys Ala Pro Phe Gly Gly Asn Leu Ser Val Ser 
385                 390                 395                 400 
Glu Arg Ile Ala Asn Thr Cys Thr Asp Leu Gly Leu Ile Val Arg Ala 
                405                 410                 415     
Leu Gly Gln Ser Val Ala Leu Ala Pro Pro Phe Ile Leu Thr Glu Ala 
            420                 425                 430         
Gln Met Asp Glu Met Phe Asp Lys Leu Glu Lys Ala Leu Asp Lys Val 
        435                 440                 445             
Phe Ala Glu Val Ala                                             
    450                                                         

 
<210> 117
<211> 1359
<212> DNA
<213> Artificial Sequence
 
<220>
<223> variant of transaminase from Vibrio fluvialis Js17
 
<400> 117
atgaacaaac cgcagagctg ggaaacgcgt gcggaaacct atagcctgta tggttttacc 60
gatatgccga gcctgcatca gcgtggcacc atggtggtga cccatggcga aggcccgtat 120
atcgtggatg tgcatggccg tcgttatctg gatgcgtgca gcggcgctgc gaacatggtg 180
gcgggctttg atcataaagg cctgattgat gcggcgaaaa cgcagtatga acgttttccg 240
ggctatcatg cggttaaagg ccgtatgagc gatcagaccg tgatgctgtc tgaaaaactg 300
gtggaagtga gcccgtttga tagcggccgt gtgttttata ccaacagcgg cagcgaagcg 360
aacgatacca tggtgaaaat gctgtggttt ctgcatgcgg cggaaggcaa accgcagaaa 420
cgtaaaattc tgacccattg gaacgcgtat catggcgcga ccgcggtgag cgcgagcatg 480
accggctttc cgtataacag cgtgtttggc ctgccgctgc cgggctttct gcatctgacc 540
tgcccgcatt attggcgtta tggcgaagaa ggcgaaaccg aagaacagtt tgtcgcgcgt 600
ctggcccatg aactggaaga aaacattcag aaggaaggcg cggataccat tgcgggcttt 660
tttgcggaac cggtgatggg tgcgggcggt gttattccgc cggcaaaagg ctattttcag 720
gcgattctgc cgatcctgcg caaatatgat attccggtga tcagcgatga agtgattacc 780
ggcttcggcc gtaccggtaa cacctggggc tgcgtgacct atgattttac cccggatgcg 840
attattagcg cgaaaggcct aaccgcgggt ttttttgcgg cgggcgcggt gattctgggt 900
ccggaactga gcaaacgtct ggaaaccgcg attgaagcgc gtgaatggtt tccgcatggt 960
tttaccacag gcggccatcc ggtgggttgt gcgattgcgc tgaaagcgat tgatgtggtg 1020
atgaacgaag gcctggccga aaacgtgcgt cgtctggccc cgcgttttga agaacgtctg 1080
aaacatattg cggaacgtcc gaacattggc gaatatcgtg gcattggctt tatgtgggcg 1140
ctggaagtcg tgaaagataa agcgagcaaa gccccgtttg gtggcaacct gagcgtgagc 1200
gaacgtattg cgaacacctg caccgatctg ggcctgattg tgcgtgcgct gggccagagc 1260
gtggcgctgg cgccgccgtt tattctgacc gaagcgcaga tggatgaaat gttcgataaa 1320
ctggaaaaag cgctggataa agtgttcgcg gaagtggcg                        1359

 
<210> 118
<211> 453
<212> PRT
<213> Artificial Sequence
 
<220>
<223> variant of transaminase from Vibrio fluvialis Js17
 
<400> 118
Met Asn Lys Pro Gln Ser Trp Glu Thr Arg Ala Glu Thr Tyr Ser Leu 
1               5                   10                  15      
Tyr Gly Phe Thr Asp Met Pro Ser Leu His Gln Arg Gly Thr Met Val 
            20                  25                  30          
Val Thr His Gly Glu Gly Pro Tyr Ile Val Asp Val His Gly Arg Arg 
        35                  40                  45              
Tyr Leu Asp Ala Cys Ser Gly Ala Ala Asn Met Val Ala Gly Phe Asp 
    50                  55                  60                  
His Lys Gly Leu Ile Asp Ala Ala Lys Thr Gln Tyr Glu Arg Phe Pro 
65                  70                  75                  80  
Gly Tyr His Ala Val Lys Gly Arg Met Ser Asp Gln Thr Val Met Leu 
                85                  90                  95      
Ser Glu Lys Leu Val Glu Val Ser Pro Phe Asp Ser Gly Arg Val Phe 
            100                 105                 110         
Tyr Thr Asn Ser Gly Ser Glu Ala Asn Asp Thr Met Val Lys Met Leu 
        115                 120                 125             
Trp Phe Leu His Ala Ala Glu Gly Lys Pro Gln Lys Arg Lys Ile Leu 
    130                 135                 140                 
Thr His Trp Asn Ala Tyr His Gly Ala Thr Ala Val Ser Ala Ser Met 
145                 150                 155                 160 
Thr Gly Phe Pro Tyr Asn Ser Val Phe Gly Leu Pro Leu Pro Gly Phe 
                165                 170                 175     
Leu His Leu Thr Cys Pro His Tyr Trp Arg Tyr Gly Glu Glu Gly Glu 
            180                 185                 190         
Thr Glu Glu Gln Phe Val Ala Arg Leu Ala His Glu Leu Glu Glu Asn 
        195                 200                 205             
Ile Gln Lys Glu Gly Ala Asp Thr Ile Ala Gly Phe Phe Ala Glu Pro 
    210                 215                 220                 
Val Met Gly Ala Gly Gly Val Ile Pro Pro Ala Lys Gly Tyr Phe Gln 
225                 230                 235                 240 
Ala Ile Leu Pro Ile Leu Arg Lys Tyr Asp Ile Pro Val Ile Ser Asp 
                245                 250                 255     
Glu Val Ile Thr Gly Phe Gly Arg Thr Gly Asn Thr Trp Gly Cys Val 
            260                 265                 270         
Thr Tyr Asp Phe Thr Pro Asp Ala Ile Ile Ser Ala Lys Gly Leu Thr 
        275                 280                 285             
Ala Gly Phe Phe Ala Ala Gly Ala Val Ile Leu Gly Pro Glu Leu Ser 
    290                 295                 300                 
Lys Arg Leu Glu Thr Ala Ile Glu Ala Arg Glu Trp Phe Pro His Gly 
305                 310                 315                 320 
Phe Thr Thr Gly Gly His Pro Val Gly Cys Ala Ile Ala Leu Lys Ala 
                325                 330                 335     
Ile Asp Val Val Met Asn Glu Gly Leu Ala Glu Asn Val Arg Arg Leu 
            340                 345                 350         
Ala Pro Arg Phe Glu Glu Arg Leu Lys His Ile Ala Glu Arg Pro Asn 
        355                 360                 365             
Ile Gly Glu Tyr Arg Gly Ile Gly Phe Met Trp Ala Leu Glu Val Val 
    370                 375                 380                 
Lys Asp Lys Ala Ser Lys Ala Pro Phe Gly Gly Asn Leu Ser Val Ser 
385                 390                 395                 400 
Glu Arg Ile Ala Asn Thr Cys Thr Asp Leu Gly Leu Ile Val Arg Ala 
                405                 410                 415     
Leu Gly Gln Ser Val Ala Leu Ala Pro Pro Phe Ile Leu Thr Glu Ala 
            420                 425                 430         
Gln Met Asp Glu Met Phe Asp Lys Leu Glu Lys Ala Leu Asp Lys Val 
        435                 440                 445             
Phe Ala Glu Val Ala                                             
    450                                                         

 
<210> 119
<211> 1359
<212> DNA
<213> Artificial Sequence
 
<220>
<223> variant of transaminase from Vibrio fluvialis Js17
 
<400> 119
atgaacaaac cgcagagctg ggaaacgcgt gcggaaacct atagcctgta tggtcatacc 60
gatatgccga gcctgcatca gcgtggcacc atggtggtga cccatggcga aggcccgtat 120
atcgtggatg tgcatggccg tcgttatctg gatgcgtgca gcggcgctgc gaacatggtg 180
gcgggctttg atcataaagg cctgattgat gcggcgaaaa cgcagtatga acgttttccg 240
ggctatcacg cggttaatgg ccgtatgagc gatcagaccg tgatgctgtc tgaaaaactg 300
gtggaagtga gcccgtttga tagcggccgt gtgttttata ccaacagcgg cagcgaagcg 360
aacgatacca tggtgaaaat gctgtggttt ctgcatgcgg cggaaggcaa accgcagaaa 420
cgtaaaattc tgacccattg gaacgcgtat catggcgcga ccgcggtgag cgcgagcatg 480
accggctttc cgtataacag cgtgtttggc ctgccgctgc cgggctttct gcatctgacc 540
tgcccgcatt attggcgtta tggcgaagaa ggcgaaaccg aagaacagtt tgtcgcgcgt 600
ctggcccatg aactggaaga aaccattcag aaggaaggcg cggataccat tgcgggcttt 660
tttgcggaac cggtgatggg tgcgggcggt gttattccgc cggcaaaagg ctattttcag 720
gcgattctgc cgatcctgcg caaatatgat attccggtga tcagcgatga agtgattacc 780
ggcttcggcc gtaccggtaa cacctggggc tgcgtgacct atgattttac cccggatgcg 840
attattagcg cgaaaggcct aaccgcgggt ttttttgcgg taggcgcggt gattctgggt 900
ccggaactga gcaaacgtct ggaaaccgcg attgaactgc gtgaatggtt tccgcatggt 960
tttaccacag gcggccatcc ggtgggttgt gcgattgcgc tgaaagcgat tgatgtggtg 1020
atgaacgaag gcctggccga aaacgtgcgt cgtctggccc cgcgttttga agaacgtctg 1080
aaacatattg cggaacgtcc gaacattggc gaatatcgtg gcattggctt tatgtgggcg 1140
ctggaagtcg tgaaagataa agcgagcaaa gccccgtttg gtggcaacct gagcgtgagc 1200
gaacgtattg cgaacacctg caccgatctg ggcctgattg tgcgtgcgct gggccagagc 1260
gtggcgctgg cgccgccgtt tattctgacc gaagcgcaga tggatgaaat gttcgataaa 1320
ctggaaaaag cgctggataa agtgttcgcg gaagtggcg                        1359

 
<210> 120
<211> 453
<212> PRT
<213> Artificial Sequence
 
<220>
<223> variant of transaminase from Vibrio fluvialis Js17
 
<400> 120
Met Asn Lys Pro Gln Ser Trp Glu Thr Arg Ala Glu Thr Tyr Ser Leu 
1               5                   10                  15      
Tyr Gly His Thr Asp Met Pro Ser Leu His Gln Arg Gly Thr Met Val 
            20                  25                  30          
Val Thr His Gly Glu Gly Pro Tyr Ile Val Asp Val His Gly Arg Arg 
        35                  40                  45              
Tyr Leu Asp Ala Cys Ser Gly Ala Ala Asn Met Val Ala Gly Phe Asp 
    50                  55                  60                  
His Lys Gly Leu Ile Asp Ala Ala Lys Thr Gln Tyr Glu Arg Phe Pro 
65                  70                  75                  80  
Gly Tyr His Ala Val Asn Gly Arg Met Ser Asp Gln Thr Val Met Leu 
                85                  90                  95      
Ser Glu Lys Leu Val Glu Val Ser Pro Phe Asp Ser Gly Arg Val Phe 
            100                 105                 110         
Tyr Thr Asn Ser Gly Ser Glu Ala Asn Asp Thr Met Val Lys Met Leu 
        115                 120                 125             
Trp Phe Leu His Ala Ala Glu Gly Lys Pro Gln Lys Arg Lys Ile Leu 
    130                 135                 140                 
Thr His Trp Asn Ala Tyr His Gly Ala Thr Ala Val Ser Ala Ser Met 
145                 150                 155                 160 
Thr Gly Phe Pro Tyr Asn Ser Val Phe Gly Leu Pro Leu Pro Gly Phe 
                165                 170                 175     
Leu His Leu Thr Cys Pro His Tyr Trp Arg Tyr Gly Glu Glu Gly Glu 
            180                 185                 190         
Thr Glu Glu Gln Phe Val Ala Arg Leu Ala His Glu Leu Glu Glu Thr 
        195                 200                 205             
Ile Gln Lys Glu Gly Ala Asp Thr Ile Ala Gly Phe Phe Ala Glu Pro 
    210                 215                 220                 
Val Met Gly Ala Gly Gly Val Ile Pro Pro Ala Lys Gly Tyr Phe Gln 
225                 230                 235                 240 
Ala Ile Leu Pro Ile Leu Arg Lys Tyr Asp Ile Pro Val Ile Ser Asp 
                245                 250                 255     
Glu Val Ile Thr Gly Phe Gly Arg Thr Gly Asn Thr Trp Gly Cys Val 
            260                 265                 270         
Thr Tyr Asp Phe Thr Pro Asp Ala Ile Ile Ser Ala Lys Gly Leu Thr 
        275                 280                 285             
Ala Gly Phe Phe Ala Val Gly Ala Val Ile Leu Gly Pro Glu Leu Ser 
    290                 295                 300                 
Lys Arg Leu Glu Thr Ala Ile Glu Leu Arg Glu Trp Phe Pro His Gly 
305                 310                 315                 320 
Phe Thr Thr Gly Gly His Pro Val Gly Cys Ala Ile Ala Leu Lys Ala 
                325                 330                 335     
Ile Asp Val Val Met Asn Glu Gly Leu Ala Glu Asn Val Arg Arg Leu 
            340                 345                 350         
Ala Pro Arg Phe Glu Glu Arg Leu Lys His Ile Ala Glu Arg Pro Asn 
        355                 360                 365             
Ile Gly Glu Tyr Arg Gly Ile Gly Phe Met Trp Ala Leu Glu Val Val 
    370                 375                 380                 
Lys Asp Lys Ala Ser Lys Ala Pro Phe Gly Gly Asn Leu Ser Val Ser 
385                 390                 395                 400 
Glu Arg Ile Ala Asn Thr Cys Thr Asp Leu Gly Leu Ile Val Arg Ala 
                405                 410                 415     
Leu Gly Gln Ser Val Ala Leu Ala Pro Pro Phe Ile Leu Thr Glu Ala 
            420                 425                 430         
Gln Met Asp Glu Met Phe Asp Lys Leu Glu Lys Ala Leu Asp Lys Val 
        435                 440                 445             
Phe Ala Glu Val Ala                                             
    450                                                         

 
<210> 121
<211> 1359
<212> DNA
<213> Artificial Sequence
 
<220>
<223> variant of transaminase from Vibrio fluvialis Js17
 
<400> 121
atgaacaaac cgcagagctg ggaaacgcgt gcggaaacct atagcctgta tggttatacc 60
gatatgccga gcctgcatca gcgtggcacc atggtggtga cccatggcga aggcccgtat 120
atcgtggatg tgcatggccg tcgttatctg gatgcgtgca gcggcgctgc gaacatggtg 180
gcgggctttg atcataaagg cctgattgat gcggcgaaaa cgcagtatga acgttttccg 240
ggctatcacg cggttaatgg ccgtatgagc gatcagaccg tgatgctgtc tgaaaaactg 300
gtggaagtga gcccgtttga tagcggccgt gtgttttata ccaacagcgg cagcgaagcg 360
aacgatacca tggtgaaaat gctgtggttt ctgcatgcgg cggaaggcaa accgcagaaa 420
cgtaaaattc tgacccattg gaacgcgtat catggcgcga ccgcggtgag cgcgagcatg 480
accggctttc cgtataacag cgtgtttggc ctgccgctgc cgggctttct gcatctgacc 540
tgcccgcatt attggcgtta tggcgaagaa ggcgaaaccg aagaacagtt tgtcgcacgt 600
ctggcccatg aactggaaga aaccattcag aaggaaggcg cggataccat tgcgggcttt 660
tttgcggaac cggtgatggg tgcgggcggt gttattccgc cggcaaaagg ctattttcag 720
gcgattctgc cgatcctgcg caaatatgat attccggtga tcagcgatga agtgattacc 780
ggcttcggcc gtaccggtaa cacctggggc tgcgtgacct atgattttac cccggatgcg 840
attattagcg cgaaaggcct aaccgcgggt ttttttgcgg taggcgcggt gattctgggt 900
ccggaactga gcaaacgtct ggaaaccgcg attgaactgc gtgaatggtt tccgcatggt 960
tataccacag gcggccatcc ggtgggttgt gcgattgcgc tgaaagcgat tgatgtggtg 1020
atgaacgaag gcctggccga aaacgtgcgt cgtctggccc cgcgttttga agaacgtctg 1080
aaacatattg cggaacgtcc gaacattggc gaatatcgtg gcattggctt tatgtgggcg 1140
ctggaagtcg tgaaagataa agcgagcaaa gccccgtttg gtggcaacct gagcgtgagc 1200
gaacgtattg cgaacacctg caccgatctg ggcctgattg tgcgggcgct aggccagagc 1260
gtggcgctgg cgccgccgtt tattctgacc gaagcgcaga tggatgaaat gttcgataaa 1320
ctggaaaaag cgctggataa agtgttcgcg gaagtggcg                        1359

 
<210> 122
<211> 453
<212> PRT
<213> Artificial Sequence
 
<220>
<223> variant of transaminase from Vibrio fluvialis Js17
 
<400> 122
Met Asn Lys Pro Gln Ser Trp Glu Thr Arg Ala Glu Thr Tyr Ser Leu 
1               5                   10                  15      
Tyr Gly Tyr Thr Asp Met Pro Ser Leu His Gln Arg Gly Thr Met Val 
            20                  25                  30          
Val Thr His Gly Glu Gly Pro Tyr Ile Val Asp Val His Gly Arg Arg 
        35                  40                  45              
Tyr Leu Asp Ala Cys Ser Gly Ala Ala Asn Met Val Ala Gly Phe Asp 
    50                  55                  60                  
His Lys Gly Leu Ile Asp Ala Ala Lys Thr Gln Tyr Glu Arg Phe Pro 
65                  70                  75                  80  
Gly Tyr His Ala Val Asn Gly Arg Met Ser Asp Gln Thr Val Met Leu 
                85                  90                  95      
Ser Glu Lys Leu Val Glu Val Ser Pro Phe Asp Ser Gly Arg Val Phe 
            100                 105                 110         
Tyr Thr Asn Ser Gly Ser Glu Ala Asn Asp Thr Met Val Lys Met Leu 
        115                 120                 125             
Trp Phe Leu His Ala Ala Glu Gly Lys Pro Gln Lys Arg Lys Ile Leu 
    130                 135                 140                 
Thr His Trp Asn Ala Tyr His Gly Ala Thr Ala Val Ser Ala Ser Met 
145                 150                 155                 160 
Thr Gly Phe Pro Tyr Asn Ser Val Phe Gly Leu Pro Leu Pro Gly Phe 
                165                 170                 175     
Leu His Leu Thr Cys Pro His Tyr Trp Arg Tyr Gly Glu Glu Gly Glu 
            180                 185                 190         
Thr Glu Glu Gln Phe Val Ala Arg Leu Ala His Glu Leu Glu Glu Thr 
        195                 200                 205             
Ile Gln Lys Glu Gly Ala Asp Thr Ile Ala Gly Phe Phe Ala Glu Pro 
    210                 215                 220                 
Val Met Gly Ala Gly Gly Val Ile Pro Pro Ala Lys Gly Tyr Phe Gln 
225                 230                 235                 240 
Ala Ile Leu Pro Ile Leu Arg Lys Tyr Asp Ile Pro Val Ile Ser Asp 
                245                 250                 255     
Glu Val Ile Thr Gly Phe Gly Arg Thr Gly Asn Thr Trp Gly Cys Val 
            260                 265                 270         
Thr Tyr Asp Phe Thr Pro Asp Ala Ile Ile Ser Ala Lys Gly Leu Thr 
        275                 280                 285             
Ala Gly Phe Phe Ala Val Gly Ala Val Ile Leu Gly Pro Glu Leu Ser 
    290                 295                 300                 
Lys Arg Leu Glu Thr Ala Ile Glu Leu Arg Glu Trp Phe Pro His Gly 
305                 310                 315                 320 
Tyr Thr Thr Gly Gly His Pro Val Gly Cys Ala Ile Ala Leu Lys Ala 
                325                 330                 335     
Ile Asp Val Val Met Asn Glu Gly Leu Ala Glu Asn Val Arg Arg Leu 
            340                 345                 350         
Ala Pro Arg Phe Glu Glu Arg Leu Lys His Ile Ala Glu Arg Pro Asn 
        355                 360                 365             
Ile Gly Glu Tyr Arg Gly Ile Gly Phe Met Trp Ala Leu Glu Val Val 
    370                 375                 380                 
Lys Asp Lys Ala Ser Lys Ala Pro Phe Gly Gly Asn Leu Ser Val Ser 
385                 390                 395                 400 
Glu Arg Ile Ala Asn Thr Cys Thr Asp Leu Gly Leu Ile Val Arg Ala 
                405                 410                 415     
Leu Gly Gln Ser Val Ala Leu Ala Pro Pro Phe Ile Leu Thr Glu Ala 
            420                 425                 430         
Gln Met Asp Glu Met Phe Asp Lys Leu Glu Lys Ala Leu Asp Lys Val 
        435                 440                 445             
Phe Ala Glu Val Ala                                             
    450                                                         

 
<210> 123
<211> 1359
<212> DNA
<213> Artificial Sequence
 
<220>
<223> variant of transaminase from Vibrio fluvialis Js17
 
<400> 123
atgaacaaac cgcagagctg ggaaacgcgt gcggaaacct atagcctgta tggttttacc 60
gatatgccga gcctgcatca gcgtggcacc atggtggtga cccatggcga aggcccgtat 120
atcgtggatg tgcatggccg tcgttatctg gatgcgtgca gcggcgcggc gaacatggtg 180
gcgggctttg atcataaagg cctgattgat gcggcgaaaa cgcagtatga acgttttccg 240
ggctatcatg cggttaaagg ccgtatgagc gatcagaccg tgatgctgtc tgaaaaactg 300
gtggaagtga gcccgtttga tagcggccgt gtgttttata ccaacagcgg cagcgaagcg 360
aacgatacca tggtgaaaat gctgtggttt ctgcatgcgg cggaaggcaa accgcagaaa 420
cgtaaaattc tgacccattg gaacgcgtat catggcgcga ccgcggtgag cgcgagcatg 480
accggctttc cgtataacag cgtgtttggc ctgccgctgc cgggctttct gcatctgacc 540
tgcccgcatt attggcgtta tggcgaagaa ggcgaaaccg aagaacagtt tgtcgcgcgt 600
ctggcccatg aactggaaga aaccattcag aaggaaggcg cggataccat tgcgggcttt 660
tttgcggaac cggtgatggg tgcgggcggt gttattccgc cggcaaaagg ctattttcag 720
gcgattctgc cgatcctgcg caaatatgat attccggtga tcagcgatga agtgattacc 780
ggcttcggcc gtaccggtaa cacctggggc tgcgtgacct atgattttac cccggatgcg 840
attattagcg cgaaaggcct aaccgcgggt ttttttgcga tgggcgcggt gattctgggt 900
ccggaactga gcaaacgtct ggaaaccgcg attgaactgc gtgaatggtt tccgcatggt 960
tttaccacag gcggccatcc ggtgggttgt gcgattgcgc tgaaagcgat tgatgtggtg 1020
atgaacgaag gcctggccga aaacgtgcgt cgtctggccc cgcgttttga agaacgtctg 1080
aaacatattg cggaacgtcc gaacattggc gaatatcgtg gcattggctt tatgtgggcg 1140
ctggaagtcg tgaaagataa agcgagcaaa gccccgtttg gtggcaacct gagcgtgagc 1200
gaacgtattg cgaacacctg caccgatctg ggcctgattg tgcgtgcgct gggccagagc 1260
gtggcgctgg cgccgccgtt tattctgacc gaagcgcaga tggatgaaat gttcgataaa 1320
ctggaaaaag cgctggataa agtgttcgcg gaagtggcg                        1359

 
<210> 124
<211> 453
<212> PRT
<213> Artificial Sequence
 
<220>
<223> variant of transaminase from Vibrio fluvialis Js17
 
<400> 124
Met Asn Lys Pro Gln Ser Trp Glu Thr Arg Ala Glu Thr Tyr Ser Leu 
1               5                   10                  15      
Tyr Gly Phe Thr Asp Met Pro Ser Leu His Gln Arg Gly Thr Met Val 
            20                  25                  30          
Val Thr His Gly Glu Gly Pro Tyr Ile Val Asp Val His Gly Arg Arg 
        35                  40                  45              
Tyr Leu Asp Ala Cys Ser Gly Ala Ala Asn Met Val Ala Gly Phe Asp 
    50                  55                  60                  
His Lys Gly Leu Ile Asp Ala Ala Lys Thr Gln Tyr Glu Arg Phe Pro 
65                  70                  75                  80  
Gly Tyr His Ala Val Lys Gly Arg Met Ser Asp Gln Thr Val Met Leu 
                85                  90                  95      
Ser Glu Lys Leu Val Glu Val Ser Pro Phe Asp Ser Gly Arg Val Phe 
            100                 105                 110         
Tyr Thr Asn Ser Gly Ser Glu Ala Asn Asp Thr Met Val Lys Met Leu 
        115                 120                 125             
Trp Phe Leu His Ala Ala Glu Gly Lys Pro Gln Lys Arg Lys Ile Leu 
    130                 135                 140                 
Thr His Trp Asn Ala Tyr His Gly Ala Thr Ala Val Ser Ala Ser Met 
145                 150                 155                 160 
Thr Gly Phe Pro Tyr Asn Ser Val Phe Gly Leu Pro Leu Pro Gly Phe 
                165                 170                 175     
Leu His Leu Thr Cys Pro His Tyr Trp Arg Tyr Gly Glu Glu Gly Glu 
            180                 185                 190         
Thr Glu Glu Gln Phe Val Ala Arg Leu Ala His Glu Leu Glu Glu Thr 
        195                 200                 205             
Ile Gln Lys Glu Gly Ala Asp Thr Ile Ala Gly Phe Phe Ala Glu Pro 
    210                 215                 220                 
Val Met Gly Ala Gly Gly Val Ile Pro Pro Ala Lys Gly Tyr Phe Gln 
225                 230                 235                 240 
Ala Ile Leu Pro Ile Leu Arg Lys Tyr Asp Ile Pro Val Ile Ser Asp 
                245                 250                 255     
Glu Val Ile Thr Gly Phe Gly Arg Thr Gly Asn Thr Trp Gly Cys Val 
            260                 265                 270         
Thr Tyr Asp Phe Thr Pro Asp Ala Ile Ile Ser Ala Lys Gly Leu Thr 
        275                 280                 285             
Ala Gly Phe Phe Ala Met Gly Ala Val Ile Leu Gly Pro Glu Leu Ser 
    290                 295                 300                 
Lys Arg Leu Glu Thr Ala Ile Glu Leu Arg Glu Trp Phe Pro His Gly 
305                 310                 315                 320 
Phe Thr Thr Gly Gly His Pro Val Gly Cys Ala Ile Ala Leu Lys Ala 
                325                 330                 335     
Ile Asp Val Val Met Asn Glu Gly Leu Ala Glu Asn Val Arg Arg Leu 
            340                 345                 350         
Ala Pro Arg Phe Glu Glu Arg Leu Lys His Ile Ala Glu Arg Pro Asn 
        355                 360                 365             
Ile Gly Glu Tyr Arg Gly Ile Gly Phe Met Trp Ala Leu Glu Val Val 
    370                 375                 380                 
Lys Asp Lys Ala Ser Lys Ala Pro Phe Gly Gly Asn Leu Ser Val Ser 
385                 390                 395                 400 
Glu Arg Ile Ala Asn Thr Cys Thr Asp Leu Gly Leu Ile Val Arg Ala 
                405                 410                 415     
Leu Gly Gln Ser Val Ala Leu Ala Pro Pro Phe Ile Leu Thr Glu Ala 
            420                 425                 430         
Gln Met Asp Glu Met Phe Asp Lys Leu Glu Lys Ala Leu Asp Lys Val 
        435                 440                 445             
Phe Ala Glu Val Ala                                             
    450                                                         

 
<210> 125
<211> 1359
<212> DNA
<213> Artificial Sequence
 
<220>
<223> variant of transaminase from Vibrio fluvialis Js17
 
<400> 125
atgaacaaac cgcagagctg ggaaacgcgt gcggaaacct atagcctgta tggttttacc 60
gatatgccga gcctgcatca gcgtggcacc atggtggtga cccatggcga aggcccgtat 120
atttttgatg tgcatggccg tcgttatctg gatgcgtgca gcggcgcggc gaacatggtg 180
gcgggctttg atcataaagg cctgattgat gcggcgaaaa cgcagtatga acgttttccg 240
ggctatcatg cggttaaagg ccgtatgagc gatcagaccg tgatgctgtc tgaaaaactg 300
gtggaagtga gcccgtttga tagcggccgt gtgttttata ccaacagcgg cagcgaagcg 360
aacgatacca tggtgaaaat gctgtggttt ctgcatgcgg cggaaggcaa accgcagaaa 420
cgtaaaattc tgacccattg gaacgcgtat catggcgcga ccgcggtgag cgcgagcatg 480
accggctttc cgtataacag cgtgtttggc ctgccgctgc cgggctttct gcatctgacc 540
tgcccgcatt attggcgttt tggcgaagaa ggcgaaaccg aagaacagtt tgtcgcgcgt 600
ctggcccatg aactggaaga aaccattcag aaggaaggcg cggataccat tgcgggcttt 660
tttgcggaac cggtgatggg tgcgggcggt gttattccgc cggcaaaagg ctattttcag 720
gcgattctgc cgatcctgcg caaatatgat attccggtga tcagcgatga agtgattacc 780
ggcttcggcc gtaccggtaa cacctggggc tgcgtgacct atgattttac cccggatgcg 840
attattagcg cgaaaggcct aaccgcgggt ttttttgcga tgggcgcggt gattctgggt 900
ccggaactga gcaaacgtct ggaaaccgcg attgaactgc gtgaatggtt tccgcatggt 960
tttaccacag gcggccatcc ggtgggttgt gcgattgcgc tgaaagcgat tgatgtggtg 1020
atgaacgaag gcctggccga aaacgtgcgt cgtctggccc cgcgttttga agaacgtctg 1080
aaacatattg cggaacgtcc gaacattggc gaatatcgtg gcattggctt tatgtgggcg 1140
ctggaagtcg tgaaagataa agcgagcaaa gccccgtttg gtggcaacct gagcgtgagc 1200
gaacgtattg cgaacacctg caccgatctg ggcctgattg tgcgtgcgct gggccagagc 1260
gtggcgctgg cgccgccgtt tattctgacc gaagcgcaga tggatgaaat gttcgataaa 1320
ctggaaaaag cgctggataa agtgttcgcg gaagtggcg                        1359

 
<210> 126
<211> 453
<212> PRT
<213> Artificial Sequence
 
<220>
<223> variant of transaminase from Vibrio fluvialis Js17
 
<400> 126
Met Asn Lys Pro Gln Ser Trp Glu Thr Arg Ala Glu Thr Tyr Ser Leu 
1               5                   10                  15      
Tyr Gly Phe Thr Asp Met Pro Ser Leu His Gln Arg Gly Thr Met Val 
            20                  25                  30          
Val Thr His Gly Glu Gly Pro Tyr Ile Phe Asp Val His Gly Arg Arg 
        35                  40                  45              
Tyr Leu Asp Ala Cys Ser Gly Ala Ala Asn Met Val Ala Gly Phe Asp 
    50                  55                  60                  
His Lys Gly Leu Ile Asp Ala Ala Lys Thr Gln Tyr Glu Arg Phe Pro 
65                  70                  75                  80  
Gly Tyr His Ala Val Lys Gly Arg Met Ser Asp Gln Thr Val Met Leu 
                85                  90                  95      
Ser Glu Lys Leu Val Glu Val Ser Pro Phe Asp Ser Gly Arg Val Phe 
            100                 105                 110         
Tyr Thr Asn Ser Gly Ser Glu Ala Asn Asp Thr Met Val Lys Met Leu 
        115                 120                 125             
Trp Phe Leu His Ala Ala Glu Gly Lys Pro Gln Lys Arg Lys Ile Leu 
    130                 135                 140                 
Thr His Trp Asn Ala Tyr His Gly Ala Thr Ala Val Ser Ala Ser Met 
145                 150                 155                 160 
Thr Gly Phe Pro Tyr Asn Ser Val Phe Gly Leu Pro Leu Pro Gly Phe 
                165                 170                 175     
Leu His Leu Thr Cys Pro His Tyr Trp Arg Phe Gly Glu Glu Gly Glu 
            180                 185                 190         
Thr Glu Glu Gln Phe Val Ala Arg Leu Ala His Glu Leu Glu Glu Thr 
        195                 200                 205             
Ile Gln Lys Glu Gly Ala Asp Thr Ile Ala Gly Phe Phe Ala Glu Pro 
    210                 215                 220                 
Val Met Gly Ala Gly Gly Val Ile Pro Pro Ala Lys Gly Tyr Phe Gln 
225                 230                 235                 240 
Ala Ile Leu Pro Ile Leu Arg Lys Tyr Asp Ile Pro Val Ile Ser Asp 
                245                 250                 255     
Glu Val Ile Thr Gly Phe Gly Arg Thr Gly Asn Thr Trp Gly Cys Val 
            260                 265                 270         
Thr Tyr Asp Phe Thr Pro Asp Ala Ile Ile Ser Ala Lys Gly Leu Thr 
        275                 280                 285             
Ala Gly Phe Phe Ala Met Gly Ala Val Ile Leu Gly Pro Glu Leu Ser 
    290                 295                 300                 
Lys Arg Leu Glu Thr Ala Ile Glu Leu Arg Glu Trp Phe Pro His Gly 
305                 310                 315                 320 
Phe Thr Thr Gly Gly His Pro Val Gly Cys Ala Ile Ala Leu Lys Ala 
                325                 330                 335     
Ile Asp Val Val Met Asn Glu Gly Leu Ala Glu Asn Val Arg Arg Leu 
            340                 345                 350         
Ala Pro Arg Phe Glu Glu Arg Leu Lys His Ile Ala Glu Arg Pro Asn 
        355                 360                 365             
Ile Gly Glu Tyr Arg Gly Ile Gly Phe Met Trp Ala Leu Glu Val Val 
    370                 375                 380                 
Lys Asp Lys Ala Ser Lys Ala Pro Phe Gly Gly Asn Leu Ser Val Ser 
385                 390                 395                 400 
Glu Arg Ile Ala Asn Thr Cys Thr Asp Leu Gly Leu Ile Val Arg Ala 
                405                 410                 415     
Leu Gly Gln Ser Val Ala Leu Ala Pro Pro Phe Ile Leu Thr Glu Ala 
            420                 425                 430         
Gln Met Asp Glu Met Phe Asp Lys Leu Glu Lys Ala Leu Asp Lys Val 
        435                 440                 445             
Phe Ala Glu Val Ala                                             
    450                                                         

 
<210> 127
<211> 1359
<212> DNA
<213> Artificial Sequence
 
<220>
<223> variant of transaminase from Vibrio fluvialis Js17
 
<400> 127
atgaacaaac cgcagagctg ggaaacgcgt gcggaaacct atagcctgta tggttttacc 60
gatatgccga gcctgcatca gcgtggcacc atggtggtga cccatggcga aggcccgtat 120
atcgtggatg tgcatggccg tcgttatctg gatgcgtgca gcggcgctgc gaacatggtg 180
gcgggctttg atcatccagg cctgattgat gcggcgaaaa cgcagtatga acgttttccg 240
ggctatcatg cggttaaagg ccgtatgagc gatcagaccg tgatgctgtc tgaaaaactg 300
gtggaagtga gcccgtttga tagcggccgt gtgttttata ccaacagcgg cagcgaagcg 360
aacgatacca tggtgaaaat gctgtggttt ctgcatgcgg cggaaggcaa accgcagaaa 420
cgtaaaattc tgacccattg gaacgcgtat catggcgcga ccgcggtgag cgcgagcatg 480
accggctttc cgtataacag cgtgtttggc ctgccgctgc cgggctttct gcatctgacc 540
tgcccgcatt attggcgtta tggcgaagaa ggcgaaaccg aagaacagtt tgtcgcgcgt 600
ctggcccatg aactggaaga aaccattcag aaggaaggcg cggataccat tgcgggcttt 660
tttgcggaac cggtgatggg tgcgggcggt gttattccgc cggcaaaagg ctattttcag 720
gcgattctgc cgatcctgcg caaatatgat attccggtga tcagcgatga agtgattacc 780
ggcttcggcc gtaccggtaa cacctggggc tgcgtgacct atgattttac cccggatgcg 840
attattagcg cgaaaggcct aaccgcgggt ttttttgcgg taggcgcggt gattctgggt 900
ccggaactga gcaaacgtct ggaaaccgcg attgaactgc gtgaatggtt tccgcatggt 960
tttaccacag gcggccatcc ggtgggttgt gcgattgcgc tgaaagcgat tgatgtggtg 1020
atgaacgaag gcctggccga aaacgtgcgt cgtctggccc cgcgttttga agaacgtctg 1080
aaacatattg cggaacggcc gaacattggc gaatatcgtg gcattggctt tatgtgggcg 1140
ctggaagtcg tgaaagataa agcgagcaaa gccccgtttc ctggcaacct gagcgtgagc 1200
gaacgtattg cgaacacctg caccgatctg ggcctgattg tgcgtgcgct gggccagagc 1260
gtggcgctgg cgccgccgtt tattctgacc gaagcgcaga tggatgaaat gttcgataaa 1320
ctggaaaaag cgctggataa agtgttcgcg gaagtggcg                        1359

 
<210> 128
<211> 453
<212> PRT
<213> Artificial Sequence
 
<220>
<223> variant of transaminase from Vibrio fluvialis Js17
 
<400> 128
Met Asn Lys Pro Gln Ser Trp Glu Thr Arg Ala Glu Thr Tyr Ser Leu 
1               5                   10                  15      
Tyr Gly Phe Thr Asp Met Pro Ser Leu His Gln Arg Gly Thr Met Val 
            20                  25                  30          
Val Thr His Gly Glu Gly Pro Tyr Ile Val Asp Val His Gly Arg Arg 
        35                  40                  45              
Tyr Leu Asp Ala Cys Ser Gly Ala Ala Asn Met Val Ala Gly Phe Asp 
    50                  55                  60                  
His Pro Gly Leu Ile Asp Ala Ala Lys Thr Gln Tyr Glu Arg Phe Pro 
65                  70                  75                  80  
Gly Tyr His Ala Val Lys Gly Arg Met Ser Asp Gln Thr Val Met Leu 
                85                  90                  95      
Ser Glu Lys Leu Val Glu Val Ser Pro Phe Asp Ser Gly Arg Val Phe 
            100                 105                 110         
Tyr Thr Asn Ser Gly Ser Glu Ala Asn Asp Thr Met Val Lys Met Leu 
        115                 120                 125             
Trp Phe Leu His Ala Ala Glu Gly Lys Pro Gln Lys Arg Lys Ile Leu 
    130                 135                 140                 
Thr His Trp Asn Ala Tyr His Gly Ala Thr Ala Val Ser Ala Ser Met 
145                 150                 155                 160 
Thr Gly Phe Pro Tyr Asn Ser Val Phe Gly Leu Pro Leu Pro Gly Phe 
                165                 170                 175     
Leu His Leu Thr Cys Pro His Tyr Trp Arg Tyr Gly Glu Glu Gly Glu 
            180                 185                 190         
Thr Glu Glu Gln Phe Val Ala Arg Leu Ala His Glu Leu Glu Glu Thr 
        195                 200                 205             
Ile Gln Lys Glu Gly Ala Asp Thr Ile Ala Gly Phe Phe Ala Glu Pro 
    210                 215                 220                 
Val Met Gly Ala Gly Gly Val Ile Pro Pro Ala Lys Gly Tyr Phe Gln 
225                 230                 235                 240 
Ala Ile Leu Pro Ile Leu Arg Lys Tyr Asp Ile Pro Val Ile Ser Asp 
                245                 250                 255     
Glu Val Ile Thr Gly Phe Gly Arg Thr Gly Asn Thr Trp Gly Cys Val 
            260                 265                 270         
Thr Tyr Asp Phe Thr Pro Asp Ala Ile Ile Ser Ala Lys Gly Leu Thr 
        275                 280                 285             
Ala Gly Phe Phe Ala Val Gly Ala Val Ile Leu Gly Pro Glu Leu Ser 
    290                 295                 300                 
Lys Arg Leu Glu Thr Ala Ile Glu Leu Arg Glu Trp Phe Pro His Gly 
305                 310                 315                 320 
Phe Thr Thr Gly Gly His Pro Val Gly Cys Ala Ile Ala Leu Lys Ala 
                325                 330                 335     
Ile Asp Val Val Met Asn Glu Gly Leu Ala Glu Asn Val Arg Arg Leu 
            340                 345                 350         
Ala Pro Arg Phe Glu Glu Arg Leu Lys His Ile Ala Glu Arg Pro Asn 
        355                 360                 365             
Ile Gly Glu Tyr Arg Gly Ile Gly Phe Met Trp Ala Leu Glu Val Val 
    370                 375                 380                 
Lys Asp Lys Ala Ser Lys Ala Pro Phe Pro Gly Asn Leu Ser Val Ser 
385                 390                 395                 400 
Glu Arg Ile Ala Asn Thr Cys Thr Asp Leu Gly Leu Ile Val Arg Ala 
                405                 410                 415     
Leu Gly Gln Ser Val Ala Leu Ala Pro Pro Phe Ile Leu Thr Glu Ala 
            420                 425                 430         
Gln Met Asp Glu Met Phe Asp Lys Leu Glu Lys Ala Leu Asp Lys Val 
        435                 440                 445             
Phe Ala Glu Val Ala                                             
    450                                                         

 
<210> 129
<211> 1359
<212> DNA
<213> Artificial Sequence
 
<220>
<223> variant of transaminase from Vibrio fluvialis Js17
 
<400> 129
atgaacaaac cgcagagctg ggaaacgcgt gcggaaacct atagcctgta tggttatacc 60
gatctgccga gcctgcatca gcgtggcacc atggtggtga cccatggcga aggcccgtat 120
atctttgatg tgcatggccg tcgttatctg gatgcgtgca gcggcgctgc gaacatggtg 180
gcgggctttg atcataaggg cctgattgat gcggcgaaaa cgcagtatga acgttttccg 240
ggctatcacg cggttaatgg ccgtatgagc gatcagaccg tgatgctgtc tgaaaaactg 300
gtggaagtga gcccgtttga tagcggccgt gtgttttata ccaacagcgg cagcgaagcg 360
aacgatacca tggtgaaaat gctgtggttt ctgcatgcgg cggaaggcaa accgcagaaa 420
cgtaaaattc tgacccattg gaacgcgtat catggcgcga ccgcggtgag cgcgagcatg 480
accggctttc cgtataacag cgtgtttggc ctgccgctgc cgggctttct gcatctgacc 540
tgcccgcatt attggcgtta tggcgaagaa ggcgaaaccg aagaacagtt tgtcgcgcgt 600
ctggcccatg aactggaaga aaccattcag aaggaaggcg cggataccat tgcgggcttt 660
tttgcggaac cggtgatggg tgcgggcggt gttattccgc cggcaaaagg ctattttcag 720
gcgattctgc cgatcctgcg caaatatgat attccggtga tcagcgatga agtgattacc 780
ggcttcggcc gtaccggtaa cacctggggc tgcgtgacct atgattttac cccggatgcg 840
attattagcg cgaaaggcct aaccgcgggt ttttttgcgg taggcgcggt gattctgggt 900
ccggaactga gcaaacgtct ggaaaccgcg attgaactgc gtgaatggtt tccgcatgca 960
tttaccacag gcggccatcc ggtgggttgt gcgattgcgc tgaaagcgat tgatgtggtg 1020
atgaacgaag gcctggccga aaacgtgcgt cgtctggccc cgcgttttga agaacgtctg 1080
aaacatattg cggaacgtcc gaacattggc gaatatcgtg gcattggctt tatgtgggcg 1140
ctggaagtcg tgaaagataa agcgagcaaa gccccgtttc ccggcaacct gagcgtgagc 1200
gaacgtattg cgaacacctg caccgatctg ggcctgattg tgcgtgcgct gggccagagc 1260
gtggcgctgg cgccgccgtt tattctgacc gaagcgcaga tggatgaaat gttcgataaa 1320
ctggaaaaag cgctggataa agtgttcgcg gaagtggcg                        1359

 
<210> 130
<211> 453
<212> PRT
<213> Artificial Sequence
 
<220>
<223> variant of transaminase from Vibrio fluvialis Js17
 
<400> 130
Met Asn Lys Pro Gln Ser Trp Glu Thr Arg Ala Glu Thr Tyr Ser Leu 
1               5                   10                  15      
Tyr Gly Tyr Thr Asp Leu Pro Ser Leu His Gln Arg Gly Thr Met Val 
            20                  25                  30          
Val Thr His Gly Glu Gly Pro Tyr Ile Phe Asp Val His Gly Arg Arg 
        35                  40                  45              
Tyr Leu Asp Ala Cys Ser Gly Ala Ala Asn Met Val Ala Gly Phe Asp 
    50                  55                  60                  
His Lys Gly Leu Ile Asp Ala Ala Lys Thr Gln Tyr Glu Arg Phe Pro 
65                  70                  75                  80  
Gly Tyr His Ala Val Asn Gly Arg Met Ser Asp Gln Thr Val Met Leu 
                85                  90                  95      
Ser Glu Lys Leu Val Glu Val Ser Pro Phe Asp Ser Gly Arg Val Phe 
            100                 105                 110         
Tyr Thr Asn Ser Gly Ser Glu Ala Asn Asp Thr Met Val Lys Met Leu 
        115                 120                 125             
Trp Phe Leu His Ala Ala Glu Gly Lys Pro Gln Lys Arg Lys Ile Leu 
    130                 135                 140                 
Thr His Trp Asn Ala Tyr His Gly Ala Thr Ala Val Ser Ala Ser Met 
145                 150                 155                 160 
Thr Gly Phe Pro Tyr Asn Ser Val Phe Gly Leu Pro Leu Pro Gly Phe 
                165                 170                 175     
Leu His Leu Thr Cys Pro His Tyr Trp Arg Tyr Gly Glu Glu Gly Glu 
            180                 185                 190         
Thr Glu Glu Gln Phe Val Ala Arg Leu Ala His Glu Leu Glu Glu Thr 
        195                 200                 205             
Ile Gln Lys Glu Gly Ala Asp Thr Ile Ala Gly Phe Phe Ala Glu Pro 
    210                 215                 220                 
Val Met Gly Ala Gly Gly Val Ile Pro Pro Ala Lys Gly Tyr Phe Gln 
225                 230                 235                 240 
Ala Ile Leu Pro Ile Leu Arg Lys Tyr Asp Ile Pro Val Ile Ser Asp 
                245                 250                 255     
Glu Val Ile Thr Gly Phe Gly Arg Thr Gly Asn Thr Trp Gly Cys Val 
            260                 265                 270         
Thr Tyr Asp Phe Thr Pro Asp Ala Ile Ile Ser Ala Lys Gly Leu Thr 
        275                 280                 285             
Ala Gly Phe Phe Ala Val Gly Ala Val Ile Leu Gly Pro Glu Leu Ser 
    290                 295                 300                 
Lys Arg Leu Glu Thr Ala Ile Glu Leu Arg Glu Trp Phe Pro His Ala 
305                 310                 315                 320 
Phe Thr Thr Gly Gly His Pro Val Gly Cys Ala Ile Ala Leu Lys Ala 
                325                 330                 335     
Ile Asp Val Val Met Asn Glu Gly Leu Ala Glu Asn Val Arg Arg Leu 
            340                 345                 350         
Ala Pro Arg Phe Glu Glu Arg Leu Lys His Ile Ala Glu Arg Pro Asn 
        355                 360                 365             
Ile Gly Glu Tyr Arg Gly Ile Gly Phe Met Trp Ala Leu Glu Val Val 
    370                 375                 380                 
Lys Asp Lys Ala Ser Lys Ala Pro Phe Pro Gly Asn Leu Ser Val Ser 
385                 390                 395                 400 
Glu Arg Ile Ala Asn Thr Cys Thr Asp Leu Gly Leu Ile Val Arg Ala 
                405                 410                 415     
Leu Gly Gln Ser Val Ala Leu Ala Pro Pro Phe Ile Leu Thr Glu Ala 
            420                 425                 430         
Gln Met Asp Glu Met Phe Asp Lys Leu Glu Lys Ala Leu Asp Lys Val 
        435                 440                 445             
Phe Ala Glu Val Ala                                             
    450                                                         

 
<210> 131
<211> 1359
<212> DNA
<213> Artificial Sequence
 
<220>
<223> variant of transaminase from Vibrio fluvialis Js17
 
<400> 131
atgaacaaac cgcagagctg ggaaacgcgt gcggaaacct atagcctgta tggttatacc 60
gatatgccga gcctgcatca gcgtggcacc atggtggtga cccatggcga aggcccgtat 120
atctttgatg tgcatggccg tcgttatctg gatgcgtgca gcggcgctgc gaacatggtg 180
gcgggctttg atcataaggg cctgattgat gcggcgaaaa cgcagtatga acgttttccg 240
ggctatcacg cggttaatgg ccgtatgagc gatcagaccg tgatgctgtc tgaaaaactg 300
gtggaagtga gcccgtttga tagcggccgt gtgttttata ccaacagcgg cagcgaagcg 360
aacgatacca tggtgaaaat gctgtggttt ctgcatgcgg cggaaggcaa accgcagaaa 420
cgtaaaattc tgacccattg gaacgcgtat catggcgcga ccgcggtgag cgcgagcatg 480
accggctttc cgtataacag cgtgtttggc ctgccgctgc cgggctttct gcatctgacc 540
tgcccgcatt attggcgtta tggcgaagaa ggcgaaaccg aagaacagtt tgtcgcgcgt 600
ctggcccatg aactggaaga aaccattcag aaggaaggcg cggataccat tgcgggcttt 660
tttgcggaac cggtgatggg tgcgggcggt gttattccgc cggcaaaagg ctattttcag 720
gcgattctgc cgatcctgcg caaatatgat attccggtga tcagcgatga agtgattacc 780
ggcttcggcc gtaccggtaa cacctggggc tgcgtaacct atgattttac cccggatgcg 840
attattagcg cgaaaggcct aaccgcgggt ttttttgcgg tgggcgcggt gattctgggt 900
ccggaactga gcaaacgtct ggaaaccgcg attgaactgc gtgaatggtt tccgcatggc 960
tttaccacag gcggccatcc ggtgggttgt gcgattgcgc tgaaagcgat tgatgtggtg 1020
atgaacgaag gcctggccga aaacgtgcgt cgtctggccc cgcgttttga agaacgtctg 1080
aaacatattg cggaacgtcc gaacattggc gaatatcgtg gcattggctt tatgtgggcg 1140
ctggaagtcg tgaaagataa agcgagcaaa gccccgtttg ggggcaacct gagcgtgagc 1200
gaacgtattg cgaacacctg caccgatctg ggcctgattg tgcgtgcgct gggccagagc 1260
gtggcgctgg cgccgccgtt tattctgacc gaagcgcaga tggatgaaat gttcgataaa 1320
ctggaaaaag cgctggataa agtgttcgcg gaagtggcg                        1359

 
<210> 132
<211> 453
<212> PRT
<213> Artificial Sequence
 
<220>
<223> variant of transaminase from Vibrio fluvialis Js17
 
<400> 132
Met Asn Lys Pro Gln Ser Trp Glu Thr Arg Ala Glu Thr Tyr Ser Leu 
1               5                   10                  15      
Tyr Gly Tyr Thr Asp Met Pro Ser Leu His Gln Arg Gly Thr Met Val 
            20                  25                  30          
Val Thr His Gly Glu Gly Pro Tyr Ile Phe Asp Val His Gly Arg Arg 
        35                  40                  45              
Tyr Leu Asp Ala Cys Ser Gly Ala Ala Asn Met Val Ala Gly Phe Asp 
    50                  55                  60                  
His Lys Gly Leu Ile Asp Ala Ala Lys Thr Gln Tyr Glu Arg Phe Pro 
65                  70                  75                  80  
Gly Tyr His Ala Val Asn Gly Arg Met Ser Asp Gln Thr Val Met Leu 
                85                  90                  95      
Ser Glu Lys Leu Val Glu Val Ser Pro Phe Asp Ser Gly Arg Val Phe 
            100                 105                 110         
Tyr Thr Asn Ser Gly Ser Glu Ala Asn Asp Thr Met Val Lys Met Leu 
        115                 120                 125             
Trp Phe Leu His Ala Ala Glu Gly Lys Pro Gln Lys Arg Lys Ile Leu 
    130                 135                 140                 
Thr His Trp Asn Ala Tyr His Gly Ala Thr Ala Val Ser Ala Ser Met 
145                 150                 155                 160 
Thr Gly Phe Pro Tyr Asn Ser Val Phe Gly Leu Pro Leu Pro Gly Phe 
                165                 170                 175     
Leu His Leu Thr Cys Pro His Tyr Trp Arg Tyr Gly Glu Glu Gly Glu 
            180                 185                 190         
Thr Glu Glu Gln Phe Val Ala Arg Leu Ala His Glu Leu Glu Glu Thr 
        195                 200                 205             
Ile Gln Lys Glu Gly Ala Asp Thr Ile Ala Gly Phe Phe Ala Glu Pro 
    210                 215                 220                 
Val Met Gly Ala Gly Gly Val Ile Pro Pro Ala Lys Gly Tyr Phe Gln 
225                 230                 235                 240 
Ala Ile Leu Pro Ile Leu Arg Lys Tyr Asp Ile Pro Val Ile Ser Asp 
                245                 250                 255     
Glu Val Ile Thr Gly Phe Gly Arg Thr Gly Asn Thr Trp Gly Cys Val 
            260                 265                 270         
Thr Tyr Asp Phe Thr Pro Asp Ala Ile Ile Ser Ala Lys Gly Leu Thr 
        275                 280                 285             
Ala Gly Phe Phe Ala Val Gly Ala Val Ile Leu Gly Pro Glu Leu Ser 
    290                 295                 300                 
Lys Arg Leu Glu Thr Ala Ile Glu Leu Arg Glu Trp Phe Pro His Gly 
305                 310                 315                 320 
Phe Thr Thr Gly Gly His Pro Val Gly Cys Ala Ile Ala Leu Lys Ala 
                325                 330                 335     
Ile Asp Val Val Met Asn Glu Gly Leu Ala Glu Asn Val Arg Arg Leu 
            340                 345                 350         
Ala Pro Arg Phe Glu Glu Arg Leu Lys His Ile Ala Glu Arg Pro Asn 
        355                 360                 365             
Ile Gly Glu Tyr Arg Gly Ile Gly Phe Met Trp Ala Leu Glu Val Val 
    370                 375                 380                 
Lys Asp Lys Ala Ser Lys Ala Pro Phe Gly Gly Asn Leu Ser Val Ser 
385                 390                 395                 400 
Glu Arg Ile Ala Asn Thr Cys Thr Asp Leu Gly Leu Ile Val Arg Ala 
                405                 410                 415     
Leu Gly Gln Ser Val Ala Leu Ala Pro Pro Phe Ile Leu Thr Glu Ala 
            420                 425                 430         
Gln Met Asp Glu Met Phe Asp Lys Leu Glu Lys Ala Leu Asp Lys Val 
        435                 440                 445             
Phe Ala Glu Val Ala                                             
    450                                                         

 
<210> 133
<211> 1359
<212> DNA
<213> Artificial Sequence
 
<220>
<223> variant of transaminase from Vibrio fluvialis Js17
 
<400> 133
atgaacaaac cgcagagctg ggaaacgcgt gcggaaacct atagcctgta tggtcatacc 60
gatatgccga gcctgcatca gcgtggcacc atggtggtga cccatggcga aggcccgtat 120
atcgttgatg tgcatggccg tcgttatctg gatgcgtgca gcggcgctgc gaacatggtg 180
gcgggctttg atcatccagg cctgattgat gcggcgaaaa cgcagtatga acgttttccg 240
ggctatcacg cggttaatgg ccgtatgagc gatcagaccg tgatgctgtc tgaaaaactg 300
gtggaagtga gcccgtttga tagcggccgt gtgttttata ccaacagcgg cagcgaagcg 360
aacgatacca tggtgaaaat gctgtggttt ctgcatgcgg cggaaggcaa accgcagaaa 420
cgtaaaattc tgacccattg gaacgcgtat catggcgcga ccgcggtgag cgcgagcatg 480
accggctttc cgtataacag cgtgtttggc ctgccgctgc cgggctttct gcatctgacc 540
tgcccgcatt attggcgtta tggcgaagaa ggcgaaaccg aagaacagtt tgtcgcgcgt 600
ctggcccatg aactggaaga aaccattcag aaggaaggcg cggataccat tgcgggcttt 660
tttgcggaac cggtgatggg tgcgggcggt gttattccgc cggcaaaagg ctattttcag 720
gcgattctgc cgatcctgcg caaatatgat attccggtga tcagcgatga agtgattacc 780
ggcttcggcc gtaccggtaa cacctggggc tgcgaaacct atgattttac cccggatgcg 840
attattagcg cgaaaggcct aaccgcgggt ttttttgcgg taggcgcggt gattctgggt 900
ccggaactga gcaaacgtct ggaaaccgcg attgaactgc gtgaatggtt tccgcatggt 960
tttaccacag gcggccatcc ggtgggttgt gcgattgcgc tgaaagcgat tgatgtggtg 1020
atgaacgaag gcctggccga aaacgtgcgt cgtctggccc cgcgttttga agaacgtctg 1080
aaacatattg cggaacgtcc gaacattggc gaatatcgtg gcattggctt tatgtgggcg 1140
ctggaagtcg tgaaagataa agcgagcaaa gccccgtttg gtggcaacct gagcgtgagc 1200
gaacgtattg cgaacacctg caccgatctg ggcctgattg tgcgtgcgct gggccagagc 1260
gtggcgctgg cgccgccgtt tattctgacc gaagcgcaga tggatgaaat gttcgataaa 1320
ctggaaaaag cgctggataa agtgttcgcg gaagtggcg                        1359

 
<210> 134
<211> 453
<212> PRT
<213> Artificial Sequence
 
<220>
<223> variant of transaminase from Vibrio fluvialis Js17
 
<400> 134
Met Asn Lys Pro Gln Ser Trp Glu Thr Arg Ala Glu Thr Tyr Ser Leu 
1               5                   10                  15      
Tyr Gly His Thr Asp Met Pro Ser Leu His Gln Arg Gly Thr Met Val 
            20                  25                  30          
Val Thr His Gly Glu Gly Pro Tyr Ile Val Asp Val His Gly Arg Arg 
        35                  40                  45              
Tyr Leu Asp Ala Cys Ser Gly Ala Ala Asn Met Val Ala Gly Phe Asp 
    50                  55                  60                  
His Pro Gly Leu Ile Asp Ala Ala Lys Thr Gln Tyr Glu Arg Phe Pro 
65                  70                  75                  80  
Gly Tyr His Ala Val Asn Gly Arg Met Ser Asp Gln Thr Val Met Leu 
                85                  90                  95      
Ser Glu Lys Leu Val Glu Val Ser Pro Phe Asp Ser Gly Arg Val Phe 
            100                 105                 110         
Tyr Thr Asn Ser Gly Ser Glu Ala Asn Asp Thr Met Val Lys Met Leu 
        115                 120                 125             
Trp Phe Leu His Ala Ala Glu Gly Lys Pro Gln Lys Arg Lys Ile Leu 
    130                 135                 140                 
Thr His Trp Asn Ala Tyr His Gly Ala Thr Ala Val Ser Ala Ser Met 
145                 150                 155                 160 
Thr Gly Phe Pro Tyr Asn Ser Val Phe Gly Leu Pro Leu Pro Gly Phe 
                165                 170                 175     
Leu His Leu Thr Cys Pro His Tyr Trp Arg Tyr Gly Glu Glu Gly Glu 
            180                 185                 190         
Thr Glu Glu Gln Phe Val Ala Arg Leu Ala His Glu Leu Glu Glu Thr 
        195                 200                 205             
Ile Gln Lys Glu Gly Ala Asp Thr Ile Ala Gly Phe Phe Ala Glu Pro 
    210                 215                 220                 
Val Met Gly Ala Gly Gly Val Ile Pro Pro Ala Lys Gly Tyr Phe Gln 
225                 230                 235                 240 
Ala Ile Leu Pro Ile Leu Arg Lys Tyr Asp Ile Pro Val Ile Ser Asp 
                245                 250                 255     
Glu Val Ile Thr Gly Phe Gly Arg Thr Gly Asn Thr Trp Gly Cys Glu 
            260                 265                 270         
Thr Tyr Asp Phe Thr Pro Asp Ala Ile Ile Ser Ala Lys Gly Leu Thr 
        275                 280                 285             
Ala Gly Phe Phe Ala Val Gly Ala Val Ile Leu Gly Pro Glu Leu Ser 
    290                 295                 300                 
Lys Arg Leu Glu Thr Ala Ile Glu Leu Arg Glu Trp Phe Pro His Gly 
305                 310                 315                 320 
Phe Thr Thr Gly Gly His Pro Val Gly Cys Ala Ile Ala Leu Lys Ala 
                325                 330                 335     
Ile Asp Val Val Met Asn Glu Gly Leu Ala Glu Asn Val Arg Arg Leu 
            340                 345                 350         
Ala Pro Arg Phe Glu Glu Arg Leu Lys His Ile Ala Glu Arg Pro Asn 
        355                 360                 365             
Ile Gly Glu Tyr Arg Gly Ile Gly Phe Met Trp Ala Leu Glu Val Val 
    370                 375                 380                 
Lys Asp Lys Ala Ser Lys Ala Pro Phe Gly Gly Asn Leu Ser Val Ser 
385                 390                 395                 400 
Glu Arg Ile Ala Asn Thr Cys Thr Asp Leu Gly Leu Ile Val Arg Ala 
                405                 410                 415     
Leu Gly Gln Ser Val Ala Leu Ala Pro Pro Phe Ile Leu Thr Glu Ala 
            420                 425                 430         
Gln Met Asp Glu Met Phe Asp Lys Leu Glu Lys Ala Leu Asp Lys Val 
        435                 440                 445             
Phe Ala Glu Val Ala                                             
    450                                                         

 
<210> 135
<211> 1359
<212> DNA
<213> Artificial Sequence
 
<220>
<223> variant of transaminase from Vibrio fluvialis Js17
 
<400> 135
atgaacaaac cgcagagctg ggaaacgcgt gcggaaacct atagcctgta tggtcatacc 60
gatatgccga gcctgcatca gcgtggcacc atggtggtga cccatggcga aggcccgtat 120
atcgttgatg tgcatggccg tcgttatctg gatgcgtgca gcggcgctgc gaacatggtg 180
gcgggctttg atcatccagg cctgattgat gcggcgaaaa cgcagtatga acgttttccg 240
ggctatcacg cggttaatgg ccgtatgagc gatcagaccg tgatgctgtc tgaaaaactg 300
gtggaagtga gcccgtttga tagcggccgt gtgttttata ccaacagcgg cagcgaagcg 360
aacgatacca tggtgaaaat gctgtggttt ctgcatgcgg cggaaggcaa accgcagaaa 420
cgtaaaattc tgacccattg gaacgcgtat catggcgcga ccgcggtgag cgcgagcatg 480
accggctttc cgtataacag cgtgtttggc ctgccgctgc cgggctttct gcatctgacc 540
tgcccgcatt attggcgtta tggcgaagaa ggcgaaaccg aagaacagtt tgtcgcgcgt 600
ctggcccatg aactggaaga aaccattcag aaggaaggcg cggataccat tgcgggcttt 660
tttgcggaac cggtgatggg tgcgggcggt gttattccgc cggcaaaagg ctattttcag 720
gcgattctgc cgatcctgcg caaatatgat attccggtga tcagcgatga agtgattacc 780
ggcttcggcc gtaccggtaa cacctggggc tgcgtgacct atgattttac cccggatgcg 840
attattagcg cgaaaggcct aaccgcgggt ttttttgcgg taggcgcggt gattctgggt 900
ccggaactga gcaaacgtct ggaaaccgcg attgaactgc gtgaatggtt tccgcatgcc 960
tttaccacag gcggccatcc ggtgggttgt gcgattgcgc tgaaagcgat tgatgtggtg 1020
atgaacgaag gcctggccga aaacgtgcgt cgtctggccc cgcgttttga agaacgtctg 1080
aaacatattg cggaacgtcc gaacattggc gaatatcgtg gcattggctt tatgtgggcg 1140
ctggaagtcg tgaaagataa agcgagcaaa gccccgtttg ggggcaacct gagcgtgagc 1200
gaacgtattg cgaacacctg caccgatctg ggcctgattg tgcgtgcgct gggccagagc 1260
gtggcgctgg cgccgccgtt tattctgacc gaagcgcaga tggatgaaat gttcgataaa 1320
ctggaaaaag cgctggataa agtgttcgcg gaagtggcg                        1359

 
<210> 136
<211> 453
<212> PRT
<213> Artificial Sequence
 
<220>
<223> variant of transaminase from Vibrio fluvialis Js17
 
<400> 136
Met Asn Lys Pro Gln Ser Trp Glu Thr Arg Ala Glu Thr Tyr Ser Leu 
1               5                   10                  15      
Tyr Gly His Thr Asp Met Pro Ser Leu His Gln Arg Gly Thr Met Val 
            20                  25                  30          
Val Thr His Gly Glu Gly Pro Tyr Ile Val Asp Val His Gly Arg Arg 
        35                  40                  45              
Tyr Leu Asp Ala Cys Ser Gly Ala Ala Asn Met Val Ala Gly Phe Asp 
    50                  55                  60                  
His Pro Gly Leu Ile Asp Ala Ala Lys Thr Gln Tyr Glu Arg Phe Pro 
65                  70                  75                  80  
Gly Tyr His Ala Val Asn Gly Arg Met Ser Asp Gln Thr Val Met Leu 
                85                  90                  95      
Ser Glu Lys Leu Val Glu Val Ser Pro Phe Asp Ser Gly Arg Val Phe 
            100                 105                 110         
Tyr Thr Asn Ser Gly Ser Glu Ala Asn Asp Thr Met Val Lys Met Leu 
        115                 120                 125             
Trp Phe Leu His Ala Ala Glu Gly Lys Pro Gln Lys Arg Lys Ile Leu 
    130                 135                 140                 
Thr His Trp Asn Ala Tyr His Gly Ala Thr Ala Val Ser Ala Ser Met 
145                 150                 155                 160 
Thr Gly Phe Pro Tyr Asn Ser Val Phe Gly Leu Pro Leu Pro Gly Phe 
                165                 170                 175     
Leu His Leu Thr Cys Pro His Tyr Trp Arg Tyr Gly Glu Glu Gly Glu 
            180                 185                 190         
Thr Glu Glu Gln Phe Val Ala Arg Leu Ala His Glu Leu Glu Glu Thr 
        195                 200                 205             
Ile Gln Lys Glu Gly Ala Asp Thr Ile Ala Gly Phe Phe Ala Glu Pro 
    210                 215                 220                 
Val Met Gly Ala Gly Gly Val Ile Pro Pro Ala Lys Gly Tyr Phe Gln 
225                 230                 235                 240 
Ala Ile Leu Pro Ile Leu Arg Lys Tyr Asp Ile Pro Val Ile Ser Asp 
                245                 250                 255     
Glu Val Ile Thr Gly Phe Gly Arg Thr Gly Asn Thr Trp Gly Cys Val 
            260                 265                 270         
Thr Tyr Asp Phe Thr Pro Asp Ala Ile Ile Ser Ala Lys Gly Leu Thr 
        275                 280                 285             
Ala Gly Phe Phe Ala Val Gly Ala Val Ile Leu Gly Pro Glu Leu Ser 
    290                 295                 300                 
Lys Arg Leu Glu Thr Ala Ile Glu Leu Arg Glu Trp Phe Pro His Ala 
305                 310                 315                 320 
Phe Thr Thr Gly Gly His Pro Val Gly Cys Ala Ile Ala Leu Lys Ala 
                325                 330                 335     
Ile Asp Val Val Met Asn Glu Gly Leu Ala Glu Asn Val Arg Arg Leu 
            340                 345                 350         
Ala Pro Arg Phe Glu Glu Arg Leu Lys His Ile Ala Glu Arg Pro Asn 
        355                 360                 365             
Ile Gly Glu Tyr Arg Gly Ile Gly Phe Met Trp Ala Leu Glu Val Val 
    370                 375                 380                 
Lys Asp Lys Ala Ser Lys Ala Pro Phe Gly Gly Asn Leu Ser Val Ser 
385                 390                 395                 400 
Glu Arg Ile Ala Asn Thr Cys Thr Asp Leu Gly Leu Ile Val Arg Ala 
                405                 410                 415     
Leu Gly Gln Ser Val Ala Leu Ala Pro Pro Phe Ile Leu Thr Glu Ala 
            420                 425                 430         
Gln Met Asp Glu Met Phe Asp Lys Leu Glu Lys Ala Leu Asp Lys Val 
        435                 440                 445             
Phe Ala Glu Val Ala                                             
    450                                                         

 
<210> 137
<211> 1359
<212> DNA
<213> Artificial Sequence
 
<220>
<223> variant of transaminase from Vibrio fluvialis Js17
 
<400> 137
atgaacaaac cgcagagctg ggaaacgcgt gcggaaacct atagcctgat gggtcatacc 60
gatatgccga gcctgcatca gcgtggcacc atggtggtga cccatggcga aggcccgtat 120
atcgtggatg tgcatggccg tcgttatctg gatgcgtgca gcggcgctgc gaacatggtg 180
gcgggctttg atcataaagg cctgattgat gcggcgaaaa cgcagtatga acgttttccg 240
ggctatcacg cggttaatgg ccgtatgagc gatcagaccg tgatgctgtc tgaaaaactg 300
gtggaagtga gcccgtttga tagcggccgt gtgttttata ccaacagcgg cagcgaagcg 360
aacgatacca tggtgaaaat gctgtggttt ctgcatgcgg cggaaggcaa accgcagaaa 420
cgtaaaattc tgacccattg gaacgcgtat catggcgcga ccgcggtgag cgcgagcatg 480
accggctttc cgtataacag cgtgtttggc ctgccgctgc cgggctttct gcatctgacc 540
tgcccgcatt attggcgtta tggcgaagaa ggcgaaaccg aagaacagtt tgtcgcgcgt 600
ctggcccatg aactggaaga aaccattcag aaggaaggcg cggataccat tgcgggcttt 660
tttgcggaac cggtgatggg tgcgggcggt gttattccgc cggcaaaagg ctattttcag 720
gcgattctgc cgatcctgcg caaatatgat attccggtga tctccgatga agtgattacc 780
ggcttcggcc gtaccggtaa cacctggggc tgcgtgacct atgattttac cccggatgcg 840
attattagcg cgaaaggcct aaccgcgggt ttttttgcgg taggcgcggt gattctgggt 900
ccggaactga gcaaacgtct ggaaaccgcg attgaactgc gtgaatggtt tccgcatgct 960
tttaccacag gtggccatcc ggtgggttgt gcgattgcgc tgaaagcgat tgatgtggtg 1020
atgaacgaag gcctggccga aaacgtgcgt cgtctggccc cgcgttttga agaacgtctg 1080
aaacatattg cggaacgtcc gaacattggc gaatatcgtg gcattggctt tatgtgggcg 1140
ctggaagtcg tgaaagataa agcgagcaaa gccccgtttg gtggcaacct gagcgtgagc 1200
gaacgtattg cgaacacctg caccgatctg ggcctgattg tgcgtgcgct gggccagagc 1260
gtggcgctgg cgccgccgtt tattctgacc gaagcgcaga tggatgaaat gttcgataaa 1320
ctggaaaaag cgctggataa agtgttcgcg gaagtggcg                        1359

 
<210> 138
<211> 453
<212> PRT
<213> Artificial Sequence
 
<220>
<223> variant of transaminase from Vibrio fluvialis Js17
 
<400> 138
Met Asn Lys Pro Gln Ser Trp Glu Thr Arg Ala Glu Thr Tyr Ser Leu 
1               5                   10                  15      
Met Gly His Thr Asp Met Pro Ser Leu His Gln Arg Gly Thr Met Val 
            20                  25                  30          
Val Thr His Gly Glu Gly Pro Tyr Ile Val Asp Val His Gly Arg Arg 
        35                  40                  45              
Tyr Leu Asp Ala Cys Ser Gly Ala Ala Asn Met Val Ala Gly Phe Asp 
    50                  55                  60                  
His Lys Gly Leu Ile Asp Ala Ala Lys Thr Gln Tyr Glu Arg Phe Pro 
65                  70                  75                  80  
Gly Tyr His Ala Val Asn Gly Arg Met Ser Asp Gln Thr Val Met Leu 
                85                  90                  95      
Ser Glu Lys Leu Val Glu Val Ser Pro Phe Asp Ser Gly Arg Val Phe 
            100                 105                 110         
Tyr Thr Asn Ser Gly Ser Glu Ala Asn Asp Thr Met Val Lys Met Leu 
        115                 120                 125             
Trp Phe Leu His Ala Ala Glu Gly Lys Pro Gln Lys Arg Lys Ile Leu 
    130                 135                 140                 
Thr His Trp Asn Ala Tyr His Gly Ala Thr Ala Val Ser Ala Ser Met 
145                 150                 155                 160 
Thr Gly Phe Pro Tyr Asn Ser Val Phe Gly Leu Pro Leu Pro Gly Phe 
                165                 170                 175     
Leu His Leu Thr Cys Pro His Tyr Trp Arg Tyr Gly Glu Glu Gly Glu 
            180                 185                 190         
Thr Glu Glu Gln Phe Val Ala Arg Leu Ala His Glu Leu Glu Glu Thr 
        195                 200                 205             
Ile Gln Lys Glu Gly Ala Asp Thr Ile Ala Gly Phe Phe Ala Glu Pro 
    210                 215                 220                 
Val Met Gly Ala Gly Gly Val Ile Pro Pro Ala Lys Gly Tyr Phe Gln 
225                 230                 235                 240 
Ala Ile Leu Pro Ile Leu Arg Lys Tyr Asp Ile Pro Val Ile Ser Asp 
                245                 250                 255     
Glu Val Ile Thr Gly Phe Gly Arg Thr Gly Asn Thr Trp Gly Cys Val 
            260                 265                 270         
Thr Tyr Asp Phe Thr Pro Asp Ala Ile Ile Ser Ala Lys Gly Leu Thr 
        275                 280                 285             
Ala Gly Phe Phe Ala Val Gly Ala Val Ile Leu Gly Pro Glu Leu Ser 
    290                 295                 300                 
Lys Arg Leu Glu Thr Ala Ile Glu Leu Arg Glu Trp Phe Pro His Ala 
305                 310                 315                 320 
Phe Thr Thr Gly Gly His Pro Val Gly Cys Ala Ile Ala Leu Lys Ala 
                325                 330                 335     
Ile Asp Val Val Met Asn Glu Gly Leu Ala Glu Asn Val Arg Arg Leu 
            340                 345                 350         
Ala Pro Arg Phe Glu Glu Arg Leu Lys His Ile Ala Glu Arg Pro Asn 
        355                 360                 365             
Ile Gly Glu Tyr Arg Gly Ile Gly Phe Met Trp Ala Leu Glu Val Val 
    370                 375                 380                 
Lys Asp Lys Ala Ser Lys Ala Pro Phe Gly Gly Asn Leu Ser Val Ser 
385                 390                 395                 400 
Glu Arg Ile Ala Asn Thr Cys Thr Asp Leu Gly Leu Ile Val Arg Ala 
                405                 410                 415     
Leu Gly Gln Ser Val Ala Leu Ala Pro Pro Phe Ile Leu Thr Glu Ala 
            420                 425                 430         
Gln Met Asp Glu Met Phe Asp Lys Leu Glu Lys Ala Leu Asp Lys Val 
        435                 440                 445             
Phe Ala Glu Val Ala                                             
    450                                                         

 
<210> 139
<211> 1359
<212> DNA
<213> Artificial Sequence
 
<220>
<223> variant of transaminase from Vibrio fluvialis Js17
 
<400> 139
atgaacaaac cgcagagctg ggaaacgcgt gcggaaacct atagcctgat gggtcatacc 60
gatctgccga gcctgcatca gcgtggcacc atggtggtga cccatggcga aggcccgtat 120
atcgtggatg tgcatggccg tcgttatctg gatgcgtgca gcggcgctgc gaacatggtg 180
gcgggctttg atcataaagg cctgattgat gcggcgaaaa cgcagtatga acgttttccg 240
ggctatcacg cggttaatgg ccgtatgagc gatcagaccg tgatgctgtc tgaaaaactg 300
gtggaagtga gcccgtttga tagcggccgt gtgttttata ccaacagcgg cagcgaagcg 360
aacgatacca tggtgaaaat gctgtggttt ctgcatgcgg cggaaggcaa accgcagaaa 420
cgtaaaattc tgacccattg gaacgcgtat catggcgcga ccgcggtgag cgcgagcatg 480
accggctttc cgtataacag cgtgtttggc ctgccgctgc cgggctttct gcatctgacc 540
tgcccgcatt attggcgtta tggcgaagaa ggcgaaaccg aagaacagtt tgtcgcgcgt 600
ctggcccatg aactggaaga aaccattcag aaggaaggcg cggataccat tgcgggcttt 660
tttgcggaac cggtgatggg tgcgggcggt gttattccgc cggcaaaagg ctattttcag 720
gcgattctgc cgatcctgcg caaatatgat attccggtga tcagcgatga agtgattacc 780
ggcttcggcc gtaccggtaa cacctggggc tgcgagacct atgattttac cccggatgcg 840
attattagcg cgaaaggcct aaccgcgggt ttttttgcgg taggcgcggt gattctgggt 900
ccggaactga gcaaacgtct ggaaaccgcg attgaactgc gtgaatggtt tccgcatggt 960
tttaccacag gcggccatcc ggtgggttgt gcgattgcgc tgaaagcgat tgatgtggtg 1020
atgaacgaag gcctggccga aaacgtgcgt cgtctggccc cgcgttttga agaacgtctg 1080
aaacatattg cggaacgtcc gaacattggc gaatatcgtg gcattggctt tatgtgggcg 1140
ctggaagtcg tgaaagataa agcgagcaaa gccccgtttg gtggcaacct gagcgtgagc 1200
gaacgtattg cgaacacctg caccgatctg ggcctgattg tgcgtgcgct gggccagagc 1260
gtggcgctgg cgccgccgtt tattctgacc gaagcgcaga tggatgaaat gttcgataaa 1320
ctggaaaaag cgctggataa agtgttcgcg gaagtggcg                        1359

 
<210> 140
<211> 453
<212> PRT
<213> Artificial Sequence
 
<220>
<223> variant of transaminase from Vibrio fluvialis Js17
 
<400> 140
Met Asn Lys Pro Gln Ser Trp Glu Thr Arg Ala Glu Thr Tyr Ser Leu 
1               5                   10                  15      
Met Gly His Thr Asp Leu Pro Ser Leu His Gln Arg Gly Thr Met Val 
            20                  25                  30          
Val Thr His Gly Glu Gly Pro Tyr Ile Val Asp Val His Gly Arg Arg 
        35                  40                  45              
Tyr Leu Asp Ala Cys Ser Gly Ala Ala Asn Met Val Ala Gly Phe Asp 
    50                  55                  60                  
His Lys Gly Leu Ile Asp Ala Ala Lys Thr Gln Tyr Glu Arg Phe Pro 
65                  70                  75                  80  
Gly Tyr His Ala Val Asn Gly Arg Met Ser Asp Gln Thr Val Met Leu 
                85                  90                  95      
Ser Glu Lys Leu Val Glu Val Ser Pro Phe Asp Ser Gly Arg Val Phe 
            100                 105                 110         
Tyr Thr Asn Ser Gly Ser Glu Ala Asn Asp Thr Met Val Lys Met Leu 
        115                 120                 125             
Trp Phe Leu His Ala Ala Glu Gly Lys Pro Gln Lys Arg Lys Ile Leu 
    130                 135                 140                 
Thr His Trp Asn Ala Tyr His Gly Ala Thr Ala Val Ser Ala Ser Met 
145                 150                 155                 160 
Thr Gly Phe Pro Tyr Asn Ser Val Phe Gly Leu Pro Leu Pro Gly Phe 
                165                 170                 175     
Leu His Leu Thr Cys Pro His Tyr Trp Arg Tyr Gly Glu Glu Gly Glu 
            180                 185                 190         
Thr Glu Glu Gln Phe Val Ala Arg Leu Ala His Glu Leu Glu Glu Thr 
        195                 200                 205             
Ile Gln Lys Glu Gly Ala Asp Thr Ile Ala Gly Phe Phe Ala Glu Pro 
    210                 215                 220                 
Val Met Gly Ala Gly Gly Val Ile Pro Pro Ala Lys Gly Tyr Phe Gln 
225                 230                 235                 240 
Ala Ile Leu Pro Ile Leu Arg Lys Tyr Asp Ile Pro Val Ile Ser Asp 
                245                 250                 255     
Glu Val Ile Thr Gly Phe Gly Arg Thr Gly Asn Thr Trp Gly Cys Glu 
            260                 265                 270         
Thr Tyr Asp Phe Thr Pro Asp Ala Ile Ile Ser Ala Lys Gly Leu Thr 
        275                 280                 285             
Ala Gly Phe Phe Ala Val Gly Ala Val Ile Leu Gly Pro Glu Leu Ser 
    290                 295                 300                 
Lys Arg Leu Glu Thr Ala Ile Glu Leu Arg Glu Trp Phe Pro His Gly 
305                 310                 315                 320 
Phe Thr Thr Gly Gly His Pro Val Gly Cys Ala Ile Ala Leu Lys Ala 
                325                 330                 335     
Ile Asp Val Val Met Asn Glu Gly Leu Ala Glu Asn Val Arg Arg Leu 
            340                 345                 350         
Ala Pro Arg Phe Glu Glu Arg Leu Lys His Ile Ala Glu Arg Pro Asn 
        355                 360                 365             
Ile Gly Glu Tyr Arg Gly Ile Gly Phe Met Trp Ala Leu Glu Val Val 
    370                 375                 380                 
Lys Asp Lys Ala Ser Lys Ala Pro Phe Gly Gly Asn Leu Ser Val Ser 
385                 390                 395                 400 
Glu Arg Ile Ala Asn Thr Cys Thr Asp Leu Gly Leu Ile Val Arg Ala 
                405                 410                 415     
Leu Gly Gln Ser Val Ala Leu Ala Pro Pro Phe Ile Leu Thr Glu Ala 
            420                 425                 430         
Gln Met Asp Glu Met Phe Asp Lys Leu Glu Lys Ala Leu Asp Lys Val 
        435                 440                 445             
Phe Ala Glu Val Ala                                             
    450                                                         

 
<210> 141
<211> 1359
<212> DNA
<213> Artificial Sequence
 
<220>
<223> variant of transaminase from Vibrio fluvialis Js17
 
<400> 141
atgaacaaac cgcagagctg ggaaacgcgt gcggaaacct atagcctgta tggtcatacc 60
gatatgccga gcctgcatca gcgtggcacc atggtggtga cccatggcga aggcccgtat 120
atcgtggatg tgcatggccg tcgttatctg gatgcgtgca gcggcgctgc gaacatggtg 180
gcgggctttg atcataaagg cctgattgat gcggcgaaaa cgcagtatga acgttttccg 240
ggctatcacg cggttaatgg ccgtatgagc gatcagaccg tgatgctgtc tgaaaaactg 300
gtggaagtga gcccgtttga tagcggccgt gtgttttata ccaacagcgg cagcgaagcg 360
aacgatacca tggtgaaaat gctgtggttt ctgcatgcgg cggaaggcaa accgcagaaa 420
cgtaaaattc tgacccattg gaacgcgtat catggcgcga ccgcggtgag cgcgagcatg 480
accggctttc cgtataacag cgtgtttggc ctgccgctgc cgggctttct gcatctgacc 540
tgcccgcatt attggcgtta tggcgaagaa ggcgaaaccg aagaacagtt tgtcgcgcgt 600
ctggcccatg aactggaaga aaccattcag aaggaaggcg cggataccat tgcgggcttt 660
tttgcggaac cggtgatggg tgcgggcggt gttattccgc cggcaaaagg ctattttcag 720
gcgattctgc cgatcctgcg caaatatgat attccggtga tcagcgatga agtgattacc 780
ggcttcggcc gtaccggtaa cacctggggc tgcgagacct atgattttac cccggatgcg 840
attattagcg cgaaaggcct aaccgcgggt ttttttgcgg taggcgcggt gattctgggt 900
ccggaactga gcaaacgtct ggaaaccgcg attgaactgc gtgaatggtt tccgcatgct 960
tttaccacag gtggccatcc ggtgggttgt gcgattgcgc tgaaagcgat tgatgtggtg 1020
atgaacgaag gcctggccga aaacgtgcgt cgtctggccc cgcgttttga agaacgtctg 1080
aaacatattg cggaacgtcc gaacattggc gaatatcgtg gcattggctt tatgtgggcg 1140
ctggaagtcg tgaaagataa agcgagcaaa gccccgtttg gtggcaacct gagcgtgagc 1200
gaacgtattg cgaacacctg caccgatctg ggcctgattg tgcgtgcgct gggccagagc 1260
gtggcgctgg cgccgccgtt tattctgacc gaagcgcaga tggatgaaat gttcgataaa 1320
ctggaaaaag cgctggataa agtgttcgcg gaagtggcg                        1359

 
<210> 142
<211> 453
<212> PRT
<213> Artificial Sequence
 
<220>
<223> variant of transaminase from Vibrio fluvialis Js17
 
<400> 142
Met Asn Lys Pro Gln Ser Trp Glu Thr Arg Ala Glu Thr Tyr Ser Leu 
1               5                   10                  15      
Tyr Gly His Thr Asp Met Pro Ser Leu His Gln Arg Gly Thr Met Val 
            20                  25                  30          
Val Thr His Gly Glu Gly Pro Tyr Ile Val Asp Val His Gly Arg Arg 
        35                  40                  45              
Tyr Leu Asp Ala Cys Ser Gly Ala Ala Asn Met Val Ala Gly Phe Asp 
    50                  55                  60                  
His Lys Gly Leu Ile Asp Ala Ala Lys Thr Gln Tyr Glu Arg Phe Pro 
65                  70                  75                  80  
Gly Tyr His Ala Val Asn Gly Arg Met Ser Asp Gln Thr Val Met Leu 
                85                  90                  95      
Ser Glu Lys Leu Val Glu Val Ser Pro Phe Asp Ser Gly Arg Val Phe 
            100                 105                 110         
Tyr Thr Asn Ser Gly Ser Glu Ala Asn Asp Thr Met Val Lys Met Leu 
        115                 120                 125             
Trp Phe Leu His Ala Ala Glu Gly Lys Pro Gln Lys Arg Lys Ile Leu 
    130                 135                 140                 
Thr His Trp Asn Ala Tyr His Gly Ala Thr Ala Val Ser Ala Ser Met 
145                 150                 155                 160 
Thr Gly Phe Pro Tyr Asn Ser Val Phe Gly Leu Pro Leu Pro Gly Phe 
                165                 170                 175     
Leu His Leu Thr Cys Pro His Tyr Trp Arg Tyr Gly Glu Glu Gly Glu 
            180                 185                 190         
Thr Glu Glu Gln Phe Val Ala Arg Leu Ala His Glu Leu Glu Glu Thr 
        195                 200                 205             
Ile Gln Lys Glu Gly Ala Asp Thr Ile Ala Gly Phe Phe Ala Glu Pro 
    210                 215                 220                 
Val Met Gly Ala Gly Gly Val Ile Pro Pro Ala Lys Gly Tyr Phe Gln 
225                 230                 235                 240 
Ala Ile Leu Pro Ile Leu Arg Lys Tyr Asp Ile Pro Val Ile Ser Asp 
                245                 250                 255     
Glu Val Ile Thr Gly Phe Gly Arg Thr Gly Asn Thr Trp Gly Cys Glu 
            260                 265                 270         
Thr Tyr Asp Phe Thr Pro Asp Ala Ile Ile Ser Ala Lys Gly Leu Thr 
        275                 280                 285             
Ala Gly Phe Phe Ala Val Gly Ala Val Ile Leu Gly Pro Glu Leu Ser 
    290                 295                 300                 
Lys Arg Leu Glu Thr Ala Ile Glu Leu Arg Glu Trp Phe Pro His Ala 
305                 310                 315                 320 
Phe Thr Thr Gly Gly His Pro Val Gly Cys Ala Ile Ala Leu Lys Ala 
                325                 330                 335     
Ile Asp Val Val Met Asn Glu Gly Leu Ala Glu Asn Val Arg Arg Leu 
            340                 345                 350         
Ala Pro Arg Phe Glu Glu Arg Leu Lys His Ile Ala Glu Arg Pro Asn 
        355                 360                 365             
Ile Gly Glu Tyr Arg Gly Ile Gly Phe Met Trp Ala Leu Glu Val Val 
    370                 375                 380                 
Lys Asp Lys Ala Ser Lys Ala Pro Phe Gly Gly Asn Leu Ser Val Ser 
385                 390                 395                 400 
Glu Arg Ile Ala Asn Thr Cys Thr Asp Leu Gly Leu Ile Val Arg Ala 
                405                 410                 415     
Leu Gly Gln Ser Val Ala Leu Ala Pro Pro Phe Ile Leu Thr Glu Ala 
            420                 425                 430         
Gln Met Asp Glu Met Phe Asp Lys Leu Glu Lys Ala Leu Asp Lys Val 
        435                 440                 445             
Phe Ala Glu Val Ala                                             
    450                                                         

 
<210> 143
<211> 1359
<212> DNA
<213> Artificial Sequence
 
<220>
<223> variant of transaminase from Vibrio fluvialis Js17
 
<400> 143
atgaacaaac cgcagagctg ggaaacgcgt gcggaaacct atagcctgat gggtcatacc 60
gatatgccga gcctgcatca gcgtggcacc atggtggtga cccatggcga aggcccgtat 120
atcgtggatg tgcatggccg tcgttatctg gatgcgtgca gcggcgctgc gaacatggtg 180
gcgggctttg atcataaagg cctgattgat gcggcgaaaa cgcagtatga acgttttccg 240
ggctatcacg cggttaatgg ccgtatgagc gatcagaccg tgatgctgtc tgaaaaactg 300
gtggaagtga gcccgtttga tagcggccgt gtgttttata ccaacagcgg cagcgaagcg 360
aacgatacca tggtgaaaat gctgtggttt ctgcatgcgg cggaaggcaa accgcagaaa 420
cgtaaaattc tgacccattg gaacgcgtat catggcgcga ccgcggtgag cgcgagcatg 480
accggctttc cgtataacag cgtgtttggc ctgccgctgc cgggctttct gcatctgacc 540
tgcccgcatt attggcgtta tggcgaagaa ggcgaaaccg aagaacagtt tgtcgcgcgt 600
ctggcccatg aactggaaga aaccattcag aaggaaggcg cggataccat tgcgggcttt 660
tttgcggaac cggtgatggg tgcgggcggt gttattccgc cggcaaaagg ctattttcag 720
gcgattctgc cgatcctgcg caaatatgat attccggtga tcagcgatga agtgattacc 780
ggcttcggcc gtaccggtaa cacctggggc tgcgagacct atgattttac cccggatgcg 840
attattagcg cgaaaggcct aaccgcgggt ttttttgcgg tgggcgcggt gattctgggt 900
ccggaactga gcaaacgtct ggaaaccgcg attgaactgc gtgaatggtt tccgcatgct 960
tttaccacag gtggccatcc ggtgggttgt gcgattgcgc tgaaagcgat tgatgtggtg 1020
atgaacgaag gcctggccga aaacgtgcgt cgtctggccc cgcgttttga agaacgtctg 1080
aaacatattg cggaacgtcc gaacattggc gaatatcgtg gcattggctt tatgtgggcg 1140
ctggaagtcg tgaaagataa agcgagcaaa gccccgtttg gtggcaacct gagcgtgagc 1200
gaacgtattg cgaacacctg caccgatctg ggcctgattg tgcgtgcgct gggccagagc 1260
gtggcgctgg cgccgccgtt tattctgacc gaagcgcaga tggatgaaat gttcgataaa 1320
ctggaaaaag cgctggataa agtgttcgcg gaagtggcg                        1359

 
<210> 144
<211> 453
<212> PRT
<213> Artificial Sequence
 
<220>
<223> variant of transaminase from Vibrio fluvialis Js17
 
<400> 144
Met Asn Lys Pro Gln Ser Trp Glu Thr Arg Ala Glu Thr Tyr Ser Leu 
1               5                   10                  15      
Met Gly His Thr Asp Met Pro Ser Leu His Gln Arg Gly Thr Met Val 
            20                  25                  30          
Val Thr His Gly Glu Gly Pro Tyr Ile Val Asp Val His Gly Arg Arg 
        35                  40                  45              
Tyr Leu Asp Ala Cys Ser Gly Ala Ala Asn Met Val Ala Gly Phe Asp 
    50                  55                  60                  
His Lys Gly Leu Ile Asp Ala Ala Lys Thr Gln Tyr Glu Arg Phe Pro 
65                  70                  75                  80  
Gly Tyr His Ala Val Asn Gly Arg Met Ser Asp Gln Thr Val Met Leu 
                85                  90                  95      
Ser Glu Lys Leu Val Glu Val Ser Pro Phe Asp Ser Gly Arg Val Phe 
            100                 105                 110         
Tyr Thr Asn Ser Gly Ser Glu Ala Asn Asp Thr Met Val Lys Met Leu 
        115                 120                 125             
Trp Phe Leu His Ala Ala Glu Gly Lys Pro Gln Lys Arg Lys Ile Leu 
    130                 135                 140                 
Thr His Trp Asn Ala Tyr His Gly Ala Thr Ala Val Ser Ala Ser Met 
145                 150                 155                 160 
Thr Gly Phe Pro Tyr Asn Ser Val Phe Gly Leu Pro Leu Pro Gly Phe 
                165                 170                 175     
Leu His Leu Thr Cys Pro His Tyr Trp Arg Tyr Gly Glu Glu Gly Glu 
            180                 185                 190         
Thr Glu Glu Gln Phe Val Ala Arg Leu Ala His Glu Leu Glu Glu Thr 
        195                 200                 205             
Ile Gln Lys Glu Gly Ala Asp Thr Ile Ala Gly Phe Phe Ala Glu Pro 
    210                 215                 220                 
Val Met Gly Ala Gly Gly Val Ile Pro Pro Ala Lys Gly Tyr Phe Gln 
225                 230                 235                 240 
Ala Ile Leu Pro Ile Leu Arg Lys Tyr Asp Ile Pro Val Ile Ser Asp 
                245                 250                 255     
Glu Val Ile Thr Gly Phe Gly Arg Thr Gly Asn Thr Trp Gly Cys Glu 
            260                 265                 270         
Thr Tyr Asp Phe Thr Pro Asp Ala Ile Ile Ser Ala Lys Gly Leu Thr 
        275                 280                 285             
Ala Gly Phe Phe Ala Val Gly Ala Val Ile Leu Gly Pro Glu Leu Ser 
    290                 295                 300                 
Lys Arg Leu Glu Thr Ala Ile Glu Leu Arg Glu Trp Phe Pro His Ala 
305                 310                 315                 320 
Phe Thr Thr Gly Gly His Pro Val Gly Cys Ala Ile Ala Leu Lys Ala 
                325                 330                 335     
Ile Asp Val Val Met Asn Glu Gly Leu Ala Glu Asn Val Arg Arg Leu 
            340                 345                 350         
Ala Pro Arg Phe Glu Glu Arg Leu Lys His Ile Ala Glu Arg Pro Asn 
        355                 360                 365             
Ile Gly Glu Tyr Arg Gly Ile Gly Phe Met Trp Ala Leu Glu Val Val 
    370                 375                 380                 
Lys Asp Lys Ala Ser Lys Ala Pro Phe Gly Gly Asn Leu Ser Val Ser 
385                 390                 395                 400 
Glu Arg Ile Ala Asn Thr Cys Thr Asp Leu Gly Leu Ile Val Arg Ala 
                405                 410                 415     
Leu Gly Gln Ser Val Ala Leu Ala Pro Pro Phe Ile Leu Thr Glu Ala 
            420                 425                 430         
Gln Met Asp Glu Met Phe Asp Lys Leu Glu Lys Ala Leu Asp Lys Val 
        435                 440                 445             
Phe Ala Glu Val Ala                                             
    450                                                         

 
<210> 145
<211> 1359
<212> DNA
<213> Artificial Sequence
 
<220>
<223> variant of transaminase from Vibrio fluvialis Js17
 
<400> 145
atgaacaaac cgcagagctg ggaaacgcgt gcggaaacct atagcctgat gggtcatacc 60
gatatgccga gcctgcatca gcgtggcacc atggtggtga cccatggcga aggcccgtat 120
attgtggatg tgcatggccg tcgttatctg gatgcgtgca gcggcgctgc gaacatggtg 180
gcgggctttg atcataaagg cctgattgat gcggcgaaaa cgcagtatga acgttttccg 240
ggctatcacg cggttaatgg ccgtatgagc gatcagaccg tgatgctgtc tgaaaaactg 300
gtggaagtga gcccgtttga tagcggccgt gtgttttata ccaacagcgg cagcgaagcg 360
aacgatacca tggtgaaaat gctgtggttt ctgcatgcgg cggaaggcaa accgcagaaa 420
cgtaaaattc tgacccattg gaacgcgtat catggcgcga ccgcggtgtc ggcgagcatg 480
accggctttc cgtataacag cgtgtttggc ctgccgctgc cgggctttct gcatctgacc 540
tgcccgcatt attggcgtta tggcgaagaa ggcgaaaccg aagaacagtt tgtcgcgcgt 600
ctggcccatg aactggaaga aaccattcag aaggaaggcg cggataccat tgcgggcttt 660
tttgcggaac cggtgatggg tgcgggcggt gttattccgc cggcaaaagg ctattttcag 720
gcgattctgc cgatcctgcg caaatatgat attccggtga tcagcgatga agtgattacc 780
ggcttcggcc gtaccggtaa cacctggggc tgcgtgacct atgattttac cccggatgcg 840
attattagcg cgaaaggcct aaccgcgggt ttttttgcgg taggcgcggt gattctgggt 900
ccggaactga gcaaacgtct ggaaaccgcg attgaactgc gtgaatggtt tccgcatggt 960
tttaccacag gcggccatcc ggtgggttgt gcgattgcgc tgaaagcgat tgatgtggtg 1020
atgaacgaag gcctggccga aaacgtgcgt cgtctggccc cgcgttttga agaacgtctg 1080
aaacatattg cggaacgtcc gaacattggc gaatatcgtg gcattggctt tatgtgggcg 1140
ctggaagtcg tgaaagataa agcgagcaaa gccccgtttg gtggcaaccc gagcgtgagc 1200
gaacgtattg cgaacacctg caccgatctg ggcctgattg tgcgtgcgct gggccagagc 1260
gtggcgctgg cgccgccgtt tattctgacc gaagcgcaga tggatgaaat gttcgataaa 1320
ctggaaaaag cgctggataa agtgttcgcg gaagtggcg                        1359

 
<210> 146
<211> 453
<212> PRT
<213> Artificial Sequence
 
<220>
<223> variant of transaminase from Vibrio fluvialis Js17
 
<400> 146
Met Asn Lys Pro Gln Ser Trp Glu Thr Arg Ala Glu Thr Tyr Ser Leu 
1               5                   10                  15      
Met Gly His Thr Asp Met Pro Ser Leu His Gln Arg Gly Thr Met Val 
            20                  25                  30          
Val Thr His Gly Glu Gly Pro Tyr Ile Val Asp Val His Gly Arg Arg 
        35                  40                  45              
Tyr Leu Asp Ala Cys Ser Gly Ala Ala Asn Met Val Ala Gly Phe Asp 
    50                  55                  60                  
His Lys Gly Leu Ile Asp Ala Ala Lys Thr Gln Tyr Glu Arg Phe Pro 
65                  70                  75                  80  
Gly Tyr His Ala Val Asn Gly Arg Met Ser Asp Gln Thr Val Met Leu 
                85                  90                  95      
Ser Glu Lys Leu Val Glu Val Ser Pro Phe Asp Ser Gly Arg Val Phe 
            100                 105                 110         
Tyr Thr Asn Ser Gly Ser Glu Ala Asn Asp Thr Met Val Lys Met Leu 
        115                 120                 125             
Trp Phe Leu His Ala Ala Glu Gly Lys Pro Gln Lys Arg Lys Ile Leu 
    130                 135                 140                 
Thr His Trp Asn Ala Tyr His Gly Ala Thr Ala Val Ser Ala Ser Met 
145                 150                 155                 160 
Thr Gly Phe Pro Tyr Asn Ser Val Phe Gly Leu Pro Leu Pro Gly Phe 
                165                 170                 175     
Leu His Leu Thr Cys Pro His Tyr Trp Arg Tyr Gly Glu Glu Gly Glu 
            180                 185                 190         
Thr Glu Glu Gln Phe Val Ala Arg Leu Ala His Glu Leu Glu Glu Thr 
        195                 200                 205             
Ile Gln Lys Glu Gly Ala Asp Thr Ile Ala Gly Phe Phe Ala Glu Pro 
    210                 215                 220                 
Val Met Gly Ala Gly Gly Val Ile Pro Pro Ala Lys Gly Tyr Phe Gln 
225                 230                 235                 240 
Ala Ile Leu Pro Ile Leu Arg Lys Tyr Asp Ile Pro Val Ile Ser Asp 
                245                 250                 255     
Glu Val Ile Thr Gly Phe Gly Arg Thr Gly Asn Thr Trp Gly Cys Val 
            260                 265                 270         
Thr Tyr Asp Phe Thr Pro Asp Ala Ile Ile Ser Ala Lys Gly Leu Thr 
        275                 280                 285             
Ala Gly Phe Phe Ala Val Gly Ala Val Ile Leu Gly Pro Glu Leu Ser 
    290                 295                 300                 
Lys Arg Leu Glu Thr Ala Ile Glu Leu Arg Glu Trp Phe Pro His Gly 
305                 310                 315                 320 
Phe Thr Thr Gly Gly His Pro Val Gly Cys Ala Ile Ala Leu Lys Ala 
                325                 330                 335     
Ile Asp Val Val Met Asn Glu Gly Leu Ala Glu Asn Val Arg Arg Leu 
            340                 345                 350         
Ala Pro Arg Phe Glu Glu Arg Leu Lys His Ile Ala Glu Arg Pro Asn 
        355                 360                 365             
Ile Gly Glu Tyr Arg Gly Ile Gly Phe Met Trp Ala Leu Glu Val Val 
    370                 375                 380                 
Lys Asp Lys Ala Ser Lys Ala Pro Phe Gly Gly Asn Pro Ser Val Ser 
385                 390                 395                 400 
Glu Arg Ile Ala Asn Thr Cys Thr Asp Leu Gly Leu Ile Val Arg Ala 
                405                 410                 415     
Leu Gly Gln Ser Val Ala Leu Ala Pro Pro Phe Ile Leu Thr Glu Ala 
            420                 425                 430         
Gln Met Asp Glu Met Phe Asp Lys Leu Glu Lys Ala Leu Asp Lys Val 
        435                 440                 445             
Phe Ala Glu Val Ala                                             
    450                                                         

 
<210> 147
<211> 1359
<212> DNA
<213> Artificial Sequence
 
<220>
<223> variant of transaminase from Vibrio fluvialis Js17
 
<400> 147
atgaacaaac cgcagagctg ggaaacgcgt gcggaaacct atagcctgat gggtcatacc 60
gatatgccga gcctgcatca gcgtggcacc atggtggtga cccatggcga aggcccgtat 120
attgtggatg tgcatggccg tcgttatctg gatgcgtgca gcggcgctgc gaacatggtg 180
gcgggctttg atcataaagg cctgattgat gcggcgaaaa cgcagtatga acgttttccg 240
ggctatcacg cggttaatgg ccgtatgagc gatcagaccg tgatgctgtc tgaaaaactg 300
gtggaagtga gcccgtttga tagcggccgt gtgttttata ccaacagcgg cagcgaagcg 360
aacgatacca tggtgaaaat gctgtggttt ctgcatgcgg cggaaggcaa accgcagaaa 420
cgtaaaattc tgacccattg gaacgcgtat catggcgcga ccgcggtgag cgcgagcatg 480
accggctttc cgtataacag cgtgtttggc ctgccgctgc cgggctttct gcatctgacc 540
tgcccgcatt attggcgtta tggcgaagaa ggcgaaaccg aagaacagtt tgtcgcgcgt 600
ctggcccatg aactggaaga aaccattcag aaggaaggcg cggataccat tgcgggcttt 660
attgcggaac cggtgatggg tgcgggcggt gttattccgc cggcaaaagg ctattttcag 720
gcgattctgc cgatcctgcg caaatatgat attccggtga tcagcgatga agtgattacc 780
ggcttcggcc gtaccggtaa cacctggggc tgcgtgacct atgattttac cccggatgcg 840
attattagcg cgaaaggcct aaccgcgggt ttttttgcgg taggcgcggt gattctgggt 900
ccggaactga gcaaacgtct ggaaaccgcg attgaactgc gtgaatggtt tccgcatgct 960
tttaccacag gcggccatcc ggtgggttgt gcgattgcgc tgaaagcgat tgatgtggtg 1020
atgaacgaag gcctggccga aaacgtgcgt cgtctggccc cgcgttttga agaacgtctg 1080
aaacatattg cggaacgtcc gaacattggc gaatatcgtg gcattggctt tatgtgggcg 1140
ctggaagtcg tgaaagataa agcgagcaaa gccccgtttg gtggcaacct gagcgtgagc 1200
gaacgtattg cgaacacctg caccgatctg ggcctgattg tgcgtgcgct gggccagagc 1260
gtggcgctgg cgccgccgtt tattctgacc gaagcgcaga tggatgaaat gttcgataaa 1320
ctggaaaaag cgctggataa agtgttcgcg gaagtggcg                        1359

 
<210> 148
<211> 453
<212> PRT
<213> Artificial Sequence
 
<220>
<223> variant of transaminase from Vibrio fluvialis Js17
 
<400> 148
Met Asn Lys Pro Gln Ser Trp Glu Thr Arg Ala Glu Thr Tyr Ser Leu 
1               5                   10                  15      
Met Gly His Thr Asp Met Pro Ser Leu His Gln Arg Gly Thr Met Val 
            20                  25                  30          
Val Thr His Gly Glu Gly Pro Tyr Ile Val Asp Val His Gly Arg Arg 
        35                  40                  45              
Tyr Leu Asp Ala Cys Ser Gly Ala Ala Asn Met Val Ala Gly Phe Asp 
    50                  55                  60                  
His Lys Gly Leu Ile Asp Ala Ala Lys Thr Gln Tyr Glu Arg Phe Pro 
65                  70                  75                  80  
Gly Tyr His Ala Val Asn Gly Arg Met Ser Asp Gln Thr Val Met Leu 
                85                  90                  95      
Ser Glu Lys Leu Val Glu Val Ser Pro Phe Asp Ser Gly Arg Val Phe 
            100                 105                 110         
Tyr Thr Asn Ser Gly Ser Glu Ala Asn Asp Thr Met Val Lys Met Leu 
        115                 120                 125             
Trp Phe Leu His Ala Ala Glu Gly Lys Pro Gln Lys Arg Lys Ile Leu 
    130                 135                 140                 
Thr His Trp Asn Ala Tyr His Gly Ala Thr Ala Val Ser Ala Ser Met 
145                 150                 155                 160 
Thr Gly Phe Pro Tyr Asn Ser Val Phe Gly Leu Pro Leu Pro Gly Phe 
                165                 170                 175     
Leu His Leu Thr Cys Pro His Tyr Trp Arg Tyr Gly Glu Glu Gly Glu 
            180                 185                 190         
Thr Glu Glu Gln Phe Val Ala Arg Leu Ala His Glu Leu Glu Glu Thr 
        195                 200                 205             
Ile Gln Lys Glu Gly Ala Asp Thr Ile Ala Gly Phe Ile Ala Glu Pro 
    210                 215                 220                 
Val Met Gly Ala Gly Gly Val Ile Pro Pro Ala Lys Gly Tyr Phe Gln 
225                 230                 235                 240 
Ala Ile Leu Pro Ile Leu Arg Lys Tyr Asp Ile Pro Val Ile Ser Asp 
                245                 250                 255     
Glu Val Ile Thr Gly Phe Gly Arg Thr Gly Asn Thr Trp Gly Cys Val 
            260                 265                 270         
Thr Tyr Asp Phe Thr Pro Asp Ala Ile Ile Ser Ala Lys Gly Leu Thr 
        275                 280                 285             
Ala Gly Phe Phe Ala Val Gly Ala Val Ile Leu Gly Pro Glu Leu Ser 
    290                 295                 300                 
Lys Arg Leu Glu Thr Ala Ile Glu Leu Arg Glu Trp Phe Pro His Ala 
305                 310                 315                 320 
Phe Thr Thr Gly Gly His Pro Val Gly Cys Ala Ile Ala Leu Lys Ala 
                325                 330                 335     
Ile Asp Val Val Met Asn Glu Gly Leu Ala Glu Asn Val Arg Arg Leu 
            340                 345                 350         
Ala Pro Arg Phe Glu Glu Arg Leu Lys His Ile Ala Glu Arg Pro Asn 
        355                 360                 365             
Ile Gly Glu Tyr Arg Gly Ile Gly Phe Met Trp Ala Leu Glu Val Val 
    370                 375                 380                 
Lys Asp Lys Ala Ser Lys Ala Pro Phe Gly Gly Asn Leu Ser Val Ser 
385                 390                 395                 400 
Glu Arg Ile Ala Asn Thr Cys Thr Asp Leu Gly Leu Ile Val Arg Ala 
                405                 410                 415     
Leu Gly Gln Ser Val Ala Leu Ala Pro Pro Phe Ile Leu Thr Glu Ala 
            420                 425                 430         
Gln Met Asp Glu Met Phe Asp Lys Leu Glu Lys Ala Leu Asp Lys Val 
        435                 440                 445             
Phe Ala Glu Val Ala                                             
    450                                                         

 
<210> 149
<211> 1359
<212> DNA
<213> Artificial Sequence
 
<220>
<223> variant of transaminase from Vibrio fluvialis Js17
 
<400> 149
atgaacaaac cgcagagctg ggaaacgcgt gcggaaacct atagcctgat gggtcatacc 60
gatatgccga gcctgcatca gcgtggcacc atggtggtga cccatggcga aggcccgtat 120
attgtggatg tgcatggccg tcgttatctg gatgcgtgca gcggcgctgc gaacatggtg 180
gcgggctttg atcataaagg cctgattgat gcggcgaaaa cgcagtatga acgttttccg 240
ggctatcacg cggttaatgg ccgtatgagc gatcagaccg tgatgctgtc tgaaaaactg 300
gtggaagtga gcccgtttga tagcggccgt gtgttttata ccaacagcgg cagcgaagcg 360
aacgatacca tggtgaaaat gctgtggttt ctgcatgcgg cggaaggcaa accgcagaaa 420
cgtaaaattc tgacccattg gaacgcgtat catggcgcga ccgcggtggg ggcgagcatg 480
accggctttc cgtataacag cgtgtttggc ctgccgctgc cgggctttct gcatctgacc 540
tgcccgcatt attggcgtta tggcgaagaa ggcgaaaccg aagaacagtt tgtcgcgcgt 600
ctggcccatg aactggaaga aaccattcag aaggaaggcg cggataccat tgcgggcttt 660
tttgcggaac cggtgatggg tgcgggcggt gttattccgc cggcaaaagg ctattttcag 720
gcgattctgc cgatcctgcg caaatatgat attccggtga tcagcgatga agtgattacc 780
ggcttcggcc gtaccggtaa cacctggggc tgcgtgacct atgattttac cccggatgcg 840
attattagcg cgaaaggcct aaccgcgggt ttttttgcgg taggcgcggt gattctgggt 900
ccggaactga gcaaacgtct ggaaaccgcg attgaactgc gtgaatggtt tccgcatgct 960
tttaccacag gcggccatcc ggtgggttgt gcgattgcgc tgaaagcgat tgatgtggtg 1020
atgaacgaag gcctggccga aaacgtgcgt cgtctggccc cgcgttttga agaacgtctg 1080
aaacatattg cggaacgtcc gaacattggc gaatatcgtg gcattggctt tatgtgggcg 1140
ctggaagtcg tgaaagataa agcgagcaaa gccccgtttg gtggcaaccc gagcgtgagc 1200
gaacgtattg cgaacacctg caccgatctg ggcctgattg tgcgtgcgct gggccagagc 1260
gtggcgctgg cgccgccgtt tattctgacc gaagcgcaga tggatgaaat gttcgataaa 1320
ctggaaaaag cgctggataa agtgttcgcg gaagtggcg                        1359

 
<210> 150
<211> 453
<212> PRT
<213> Artificial Sequence
 
<220>
<223> variant of transaminase from Vibrio fluvialis Js17
 
<400> 150
Met Asn Lys Pro Gln Ser Trp Glu Thr Arg Ala Glu Thr Tyr Ser Leu 
1               5                   10                  15      
Met Gly His Thr Asp Met Pro Ser Leu His Gln Arg Gly Thr Met Val 
            20                  25                  30          
Val Thr His Gly Glu Gly Pro Tyr Ile Val Asp Val His Gly Arg Arg 
        35                  40                  45              
Tyr Leu Asp Ala Cys Ser Gly Ala Ala Asn Met Val Ala Gly Phe Asp 
    50                  55                  60                  
His Lys Gly Leu Ile Asp Ala Ala Lys Thr Gln Tyr Glu Arg Phe Pro 
65                  70                  75                  80  
Gly Tyr His Ala Val Asn Gly Arg Met Ser Asp Gln Thr Val Met Leu 
                85                  90                  95      
Ser Glu Lys Leu Val Glu Val Ser Pro Phe Asp Ser Gly Arg Val Phe 
            100                 105                 110         
Tyr Thr Asn Ser Gly Ser Glu Ala Asn Asp Thr Met Val Lys Met Leu 
        115                 120                 125             
Trp Phe Leu His Ala Ala Glu Gly Lys Pro Gln Lys Arg Lys Ile Leu 
    130                 135                 140                 
Thr His Trp Asn Ala Tyr His Gly Ala Thr Ala Val Gly Ala Ser Met 
145                 150                 155                 160 
Thr Gly Phe Pro Tyr Asn Ser Val Phe Gly Leu Pro Leu Pro Gly Phe 
                165                 170                 175     
Leu His Leu Thr Cys Pro His Tyr Trp Arg Tyr Gly Glu Glu Gly Glu 
            180                 185                 190         
Thr Glu Glu Gln Phe Val Ala Arg Leu Ala His Glu Leu Glu Glu Thr 
        195                 200                 205             
Ile Gln Lys Glu Gly Ala Asp Thr Ile Ala Gly Phe Phe Ala Glu Pro 
    210                 215                 220                 
Val Met Gly Ala Gly Gly Val Ile Pro Pro Ala Lys Gly Tyr Phe Gln 
225                 230                 235                 240 
Ala Ile Leu Pro Ile Leu Arg Lys Tyr Asp Ile Pro Val Ile Ser Asp 
                245                 250                 255     
Glu Val Ile Thr Gly Phe Gly Arg Thr Gly Asn Thr Trp Gly Cys Val 
            260                 265                 270         
Thr Tyr Asp Phe Thr Pro Asp Ala Ile Ile Ser Ala Lys Gly Leu Thr 
        275                 280                 285             
Ala Gly Phe Phe Ala Val Gly Ala Val Ile Leu Gly Pro Glu Leu Ser 
    290                 295                 300                 
Lys Arg Leu Glu Thr Ala Ile Glu Leu Arg Glu Trp Phe Pro His Ala 
305                 310                 315                 320 
Phe Thr Thr Gly Gly His Pro Val Gly Cys Ala Ile Ala Leu Lys Ala 
                325                 330                 335     
Ile Asp Val Val Met Asn Glu Gly Leu Ala Glu Asn Val Arg Arg Leu 
            340                 345                 350         
Ala Pro Arg Phe Glu Glu Arg Leu Lys His Ile Ala Glu Arg Pro Asn 
        355                 360                 365             
Ile Gly Glu Tyr Arg Gly Ile Gly Phe Met Trp Ala Leu Glu Val Val 
    370                 375                 380                 
Lys Asp Lys Ala Ser Lys Ala Pro Phe Gly Gly Asn Pro Ser Val Ser 
385                 390                 395                 400 
Glu Arg Ile Ala Asn Thr Cys Thr Asp Leu Gly Leu Ile Val Arg Ala 
                405                 410                 415     
Leu Gly Gln Ser Val Ala Leu Ala Pro Pro Phe Ile Leu Thr Glu Ala 
            420                 425                 430         
Gln Met Asp Glu Met Phe Asp Lys Leu Glu Lys Ala Leu Asp Lys Val 
        435                 440                 445             
Phe Ala Glu Val Ala                                             
    450                                                         

 
<210> 151
<211> 1359
<212> DNA
<213> Artificial Sequence
 
<220>
<223> variant of transaminase from Vibrio fluvialis Js17
 
<400> 151
atgaacaaac cgcagagctg ggaaacgcgt gcggaaacct atagcctgat gggtcatacc 60
gatatgccga gcctgcatca gcgtggcacc atggtggtga cccatggcga aggcccgtat 120
atcgtggatg tgcatggccg tcgttatctg gatgcgtgca gcggcgctgc gaacatggtg 180
gcgggctttg atcataaagg cctgattgat gcggcgaaaa cgcagtatga acgttttccg 240
ggctatcact cggttaatgg ccgtatgagc gatcagaccg tgatgctgtc tgaaaaactg 300
gtggaagtga gcccgtttga tagcggccgt gtgttttata ccaacagcgg cagcgaagcg 360
aacgatacca tggtgaaaat gctgtggttt ctgcatgcgg cggaaggcaa accgcagaaa 420
cgtaaaattc tgacccattg gaacgcgtat catggcgcga ccgcggtgag cgcgagcatg 480
acgggcttcc ggtataacag cgtgtttggc ctgccgctgc cgggctttct gcatctgacc 540
tgcccgcatt attggcgtta tggcgaagaa ggcgaaaccg aagaacagtt tgtcgcgcgt 600
ctggcccatg aactggaaga aaccattcag aaggaaggcg cggataccat tgcgggcttt 660
tttgcggaac cggtgatggg tgcgggcggt gttattccgc cggcaaaagg ctattttcag 720
gcgattctgc cgatcctgcg caaatatgat attccggtga tcagcgatga agtgattacc 780
ggcttcggcc gtaccggtaa cacctggggc tgcgtgacct atgattttac cccggatgcg 840
attattagcg cgaaaggcct aaccgcgggt ttttttgcgg taggcgcggt gattctgggt 900
ccggaactga gcaaacgtct ggaaaccgcg attgaactgc gtgaatggtt tccgcatggt 960
tttaccacag gcggccatcc ggtgggttgt gcgattgcgc tgaaagcgat tgatgtggtg 1020
atgaacgaag gcctggccga aaacgtgcgt cgtctggccc cgcgttttga agaacgtctg 1080
aaacatattg cggaacgtcc gaacattggc gaatatcgtg gcattggctt tatgtgggcg 1140
ctggaagtcg tgaaagataa agcgagcaaa gccccgtttg gtggcaacct gagcgtgagc 1200
gaacgtattg cgaacacctg caccgatctg ggcctgattg tgcgtgcgct gggccagagc 1260
gtggcgctgg cgccgccgtt tattctgacc gaagcgcaga tggatgaaat gttcgataaa 1320
ctggaaaaag cgctggataa agtgttcgcg gaagtggcg                        1359

 
<210> 152
<211> 453
<212> PRT
<213> Artificial Sequence
 
<220>
<223> variant of transaminase from Vibrio fluvialis Js17
 
<400> 152
Met Asn Lys Pro Gln Ser Trp Glu Thr Arg Ala Glu Thr Tyr Ser Leu 
1               5                   10                  15      
Met Gly His Thr Asp Met Pro Ser Leu His Gln Arg Gly Thr Met Val 
            20                  25                  30          
Val Thr His Gly Glu Gly Pro Tyr Ile Val Asp Val His Gly Arg Arg 
        35                  40                  45              
Tyr Leu Asp Ala Cys Ser Gly Ala Ala Asn Met Val Ala Gly Phe Asp 
    50                  55                  60                  
His Lys Gly Leu Ile Asp Ala Ala Lys Thr Gln Tyr Glu Arg Phe Pro 
65                  70                  75                  80  
Gly Tyr His Ser Val Asn Gly Arg Met Ser Asp Gln Thr Val Met Leu 
                85                  90                  95      
Ser Glu Lys Leu Val Glu Val Ser Pro Phe Asp Ser Gly Arg Val Phe 
            100                 105                 110         
Tyr Thr Asn Ser Gly Ser Glu Ala Asn Asp Thr Met Val Lys Met Leu 
        115                 120                 125             
Trp Phe Leu His Ala Ala Glu Gly Lys Pro Gln Lys Arg Lys Ile Leu 
    130                 135                 140                 
Thr His Trp Asn Ala Tyr His Gly Ala Thr Ala Val Ser Ala Ser Met 
145                 150                 155                 160 
Thr Gly Phe Arg Tyr Asn Ser Val Phe Gly Leu Pro Leu Pro Gly Phe 
                165                 170                 175     
Leu His Leu Thr Cys Pro His Tyr Trp Arg Tyr Gly Glu Glu Gly Glu 
            180                 185                 190         
Thr Glu Glu Gln Phe Val Ala Arg Leu Ala His Glu Leu Glu Glu Thr 
        195                 200                 205             
Ile Gln Lys Glu Gly Ala Asp Thr Ile Ala Gly Phe Phe Ala Glu Pro 
    210                 215                 220                 
Val Met Gly Ala Gly Gly Val Ile Pro Pro Ala Lys Gly Tyr Phe Gln 
225                 230                 235                 240 
Ala Ile Leu Pro Ile Leu Arg Lys Tyr Asp Ile Pro Val Ile Ser Asp 
                245                 250                 255     
Glu Val Ile Thr Gly Phe Gly Arg Thr Gly Asn Thr Trp Gly Cys Val 
            260                 265                 270         
Thr Tyr Asp Phe Thr Pro Asp Ala Ile Ile Ser Ala Lys Gly Leu Thr 
        275                 280                 285             
Ala Gly Phe Phe Ala Val Gly Ala Val Ile Leu Gly Pro Glu Leu Ser 
    290                 295                 300                 
Lys Arg Leu Glu Thr Ala Ile Glu Leu Arg Glu Trp Phe Pro His Gly 
305                 310                 315                 320 
Phe Thr Thr Gly Gly His Pro Val Gly Cys Ala Ile Ala Leu Lys Ala 
                325                 330                 335     
Ile Asp Val Val Met Asn Glu Gly Leu Ala Glu Asn Val Arg Arg Leu 
            340                 345                 350         
Ala Pro Arg Phe Glu Glu Arg Leu Lys His Ile Ala Glu Arg Pro Asn 
        355                 360                 365             
Ile Gly Glu Tyr Arg Gly Ile Gly Phe Met Trp Ala Leu Glu Val Val 
    370                 375                 380                 
Lys Asp Lys Ala Ser Lys Ala Pro Phe Gly Gly Asn Leu Ser Val Ser 
385                 390                 395                 400 
Glu Arg Ile Ala Asn Thr Cys Thr Asp Leu Gly Leu Ile Val Arg Ala 
                405                 410                 415     
Leu Gly Gln Ser Val Ala Leu Ala Pro Pro Phe Ile Leu Thr Glu Ala 
            420                 425                 430         
Gln Met Asp Glu Met Phe Asp Lys Leu Glu Lys Ala Leu Asp Lys Val 
        435                 440                 445             
Phe Ala Glu Val Ala                                             
    450                                                         

 
<210> 153
<211> 1359
<212> DNA
<213> Artificial Sequence
 
<220>
<223> variant of transaminase from Vibrio fluvialis Js17
 
<400> 153
atgaacaaac cgcagagctg ggaaacgcgt gcggaaacct atagcctgat gggtcatacc 60
gatatgccga gcctgcatca gcgtggcacc atggtggtga cccatggcga aggcccgtat 120
atcgtggatg tgcatggccg tcgttatctg gatgcgtgca gcggcgctgc gaacatggtg 180
gcgggctttg atcatccagg cctgattgat gcggcgaaaa cgcagtatga acgttttccg 240
ggctatcacg cggttaatgg ccgtatgagc gatcagaccg tgatgctgtc tgaaaaactg 300
gtggaagtga gcccgtttga tagcggccgt gtgttttata ccaacagcgg cagcgaagcg 360
aacgatacca tggtgaaaat gctgtggttt ctgcatgcgg cggaaggcaa accgcagaaa 420
cgtaaaattc tgacccattg gaacgcgtat catggcgcga ccgcggtgag cgcgagcatg 480
accggctttc cgtggaacag cgtgtttggc ctgccgctgc cgggctttct gcatctgacc 540
tgcccgcatt attggcgtta tggcgaagaa ggcgaaaccg aagaacagtt tgtcgcgcgt 600
ctggcccatg aactggaaga aaccattcag aaggaaggcg cggataccat tgcgggcttt 660
tttgcggaac cggtgatggg tgcgggcggt gttattccgc cggcaaaagg ctattttcag 720
gcgattctgc cgatcctgcg caaatatgat attccggtga tctccgatga agtgattacc 780
ggcttcggcc gtaccggtaa cacctggggc tgcgtgacct atgattttac cccggatgcg 840
attattagcg cgaaaggcct aaccgcgggt ttttttgcgg taggcgcggt gattctgggt 900
ccggaactga gcaaacgtct ggaaaccgcg attgaactgc gtgaatggtt tccgcatgct 960
tttaccacag gtggccatcc ggtgggttgt gcgattgcgc tgaaagcgat tgatgtggtg 1020
atgaacgaag gcctggccga aaacgtgcgt cgtctggccc cgcgttttga agaacgtctg 1080
aaacatattg cggaacgtcc gaacattggc gaatatcgtg gcattggctt tatgtgggcg 1140
ctggaagtcg tgaaagataa agcgagcaaa gccccgtttg gtggcaacct gagcgtgagc 1200
gaacgtattg cgaacacctg caccgatctg ggcctgattg tgcgtgcgct gggccagagc 1260
gtggcgctgg cgccgccgtt tattctgacc gaagcgcaga tggatgaaat gttcgataaa 1320
ctggaaaaag cgctggataa agtgttcgcg gaagtggcg                        1359

 
<210> 154
<211> 453
<212> PRT
<213> Artificial Sequence
 
<220>
<223> variant of transaminase from Vibrio fluvialis Js17
 
<400> 154
Met Asn Lys Pro Gln Ser Trp Glu Thr Arg Ala Glu Thr Tyr Ser Leu 
1               5                   10                  15      
Met Gly His Thr Asp Met Pro Ser Leu His Gln Arg Gly Thr Met Val 
            20                  25                  30          
Val Thr His Gly Glu Gly Pro Tyr Ile Val Asp Val His Gly Arg Arg 
        35                  40                  45              
Tyr Leu Asp Ala Cys Ser Gly Ala Ala Asn Met Val Ala Gly Phe Asp 
    50                  55                  60                  
His Pro Gly Leu Ile Asp Ala Ala Lys Thr Gln Tyr Glu Arg Phe Pro 
65                  70                  75                  80  
Gly Tyr His Ala Val Asn Gly Arg Met Ser Asp Gln Thr Val Met Leu 
                85                  90                  95      
Ser Glu Lys Leu Val Glu Val Ser Pro Phe Asp Ser Gly Arg Val Phe 
            100                 105                 110         
Tyr Thr Asn Ser Gly Ser Glu Ala Asn Asp Thr Met Val Lys Met Leu 
        115                 120                 125             
Trp Phe Leu His Ala Ala Glu Gly Lys Pro Gln Lys Arg Lys Ile Leu 
    130                 135                 140                 
Thr His Trp Asn Ala Tyr His Gly Ala Thr Ala Val Ser Ala Ser Met 
145                 150                 155                 160 
Thr Gly Phe Pro Trp Asn Ser Val Phe Gly Leu Pro Leu Pro Gly Phe 
                165                 170                 175     
Leu His Leu Thr Cys Pro His Tyr Trp Arg Tyr Gly Glu Glu Gly Glu 
            180                 185                 190         
Thr Glu Glu Gln Phe Val Ala Arg Leu Ala His Glu Leu Glu Glu Thr 
        195                 200                 205             
Ile Gln Lys Glu Gly Ala Asp Thr Ile Ala Gly Phe Phe Ala Glu Pro 
    210                 215                 220                 
Val Met Gly Ala Gly Gly Val Ile Pro Pro Ala Lys Gly Tyr Phe Gln 
225                 230                 235                 240 
Ala Ile Leu Pro Ile Leu Arg Lys Tyr Asp Ile Pro Val Ile Ser Asp 
                245                 250                 255     
Glu Val Ile Thr Gly Phe Gly Arg Thr Gly Asn Thr Trp Gly Cys Val 
            260                 265                 270         
Thr Tyr Asp Phe Thr Pro Asp Ala Ile Ile Ser Ala Lys Gly Leu Thr 
        275                 280                 285             
Ala Gly Phe Phe Ala Val Gly Ala Val Ile Leu Gly Pro Glu Leu Ser 
    290                 295                 300                 
Lys Arg Leu Glu Thr Ala Ile Glu Leu Arg Glu Trp Phe Pro His Ala 
305                 310                 315                 320 
Phe Thr Thr Gly Gly His Pro Val Gly Cys Ala Ile Ala Leu Lys Ala 
                325                 330                 335     
Ile Asp Val Val Met Asn Glu Gly Leu Ala Glu Asn Val Arg Arg Leu 
            340                 345                 350         
Ala Pro Arg Phe Glu Glu Arg Leu Lys His Ile Ala Glu Arg Pro Asn 
        355                 360                 365             
Ile Gly Glu Tyr Arg Gly Ile Gly Phe Met Trp Ala Leu Glu Val Val 
    370                 375                 380                 
Lys Asp Lys Ala Ser Lys Ala Pro Phe Gly Gly Asn Leu Ser Val Ser 
385                 390                 395                 400 
Glu Arg Ile Ala Asn Thr Cys Thr Asp Leu Gly Leu Ile Val Arg Ala 
                405                 410                 415     
Leu Gly Gln Ser Val Ala Leu Ala Pro Pro Phe Ile Leu Thr Glu Ala 
            420                 425                 430         
Gln Met Asp Glu Met Phe Asp Lys Leu Glu Lys Ala Leu Asp Lys Val 
        435                 440                 445             
Phe Ala Glu Val Ala                                             
    450                                                         

 
<210> 155
<211> 1359
<212> DNA
<213> Artificial Sequence
 
<220>
<223> variant of transaminase from Vibrio fluvialis Js17
 
<400> 155
atgaacaaac cgcagagctg ggaaacgcgt gcggaaacct atagcctgat gggtcatacc 60
gatatgccga gcctgcatca gcgtggcacc atggtggtga cccatggcga aggcccgtat 120
atttttgatg tgcatggccg tcgttatctg gatgcgtgca gcggcgctgc gaacatggtg 180
gcgggctttg atcatccagg cctgattgat gcggcgaaaa cgcagtatga acgttttccg 240
ggctatcacg cggttaatgg ccgtatgagc gatcagaccg tgatgctgtc tgaaaaactg 300
gtggaagtga gcccgtttga tagcggccgt gtgttttata ccaacagcgg cagcgaagcg 360
aacgatacca tggtgaaaat gctgtggttt ctgcatgcgg cggaaggcaa accgcagaaa 420
cgtaaaattc tgacccattg gaacgcgtat catggcgcga ccgcggtgag cgcgagcatg 480
accggctttc cgtggaacag cgtgtttggc ctgccgctgc cgggctttct gcatctgacc 540
tgcccgcatt attggcgtta tggcgaagaa ggcgaaaccg aagaacagtt tgtcgcgcgt 600
ctggcccatg aactggaaga aaccattcag aaggaaggcg cggataccat tgcgggcttt 660
tttgcggaac cggtgatggg tgcgggcggt gttattccgc cggcaaaagg ctattttcag 720
gcgattctgc cgatcctgcg caaatatgat attccggtga tctccgatga agtgattacc 780
ggcttcggcc gtaccggtaa cacctggggc tgcgtaacct atgattttac cccggatgcg 840
attattagcg cgaaaggcct aaccgcgggt ttttttgcgg taggcgcggt gattctgggt 900
ccggaactga gcaaacgtct ggaaaccgcg attgaactgc gtgaatggtt tccgcatgct 960
tttaccacag gtggccatcc ggtgggttgt gcgattgcgc tgaaagcgat tgatgtggtg 1020
atgaacgaag gcctggccga aaacgtgcgt cgtctggccc cgcgttttga agaacgtctg 1080
aaacatattg cggaacgtcc gaacattggc gaatatcgtg gcattggctt tatgtgggcg 1140
ctggaagtcg tgaaagataa agcgagcaaa gccccgtttc ccggcaacct gagcgtgagc 1200
gaacgtattg cgaacacctg caccgatctg ggcctgattg tgcgtgcgct gggccagagc 1260
gtggcgctgg cgccgccgtt tattctgacc gaagcgcaga tggatgaaat gttcgataaa 1320
ctggaaaaag cgctggataa agtgttcgcg gaagtggcg                        1359

 
<210> 156
<211> 453
<212> PRT
<213> Artificial Sequence
 
<220>
<223> variant of transaminase from Vibrio fluvialis Js17
 
<400> 156
Met Asn Lys Pro Gln Ser Trp Glu Thr Arg Ala Glu Thr Tyr Ser Leu 
1               5                   10                  15      
Met Gly His Thr Asp Met Pro Ser Leu His Gln Arg Gly Thr Met Val 
            20                  25                  30          
Val Thr His Gly Glu Gly Pro Tyr Ile Phe Asp Val His Gly Arg Arg 
        35                  40                  45              
Tyr Leu Asp Ala Cys Ser Gly Ala Ala Asn Met Val Ala Gly Phe Asp 
    50                  55                  60                  
His Pro Gly Leu Ile Asp Ala Ala Lys Thr Gln Tyr Glu Arg Phe Pro 
65                  70                  75                  80  
Gly Tyr His Ala Val Asn Gly Arg Met Ser Asp Gln Thr Val Met Leu 
                85                  90                  95      
Ser Glu Lys Leu Val Glu Val Ser Pro Phe Asp Ser Gly Arg Val Phe 
            100                 105                 110         
Tyr Thr Asn Ser Gly Ser Glu Ala Asn Asp Thr Met Val Lys Met Leu 
        115                 120                 125             
Trp Phe Leu His Ala Ala Glu Gly Lys Pro Gln Lys Arg Lys Ile Leu 
    130                 135                 140                 
Thr His Trp Asn Ala Tyr His Gly Ala Thr Ala Val Ser Ala Ser Met 
145                 150                 155                 160 
Thr Gly Phe Pro Trp Asn Ser Val Phe Gly Leu Pro Leu Pro Gly Phe 
                165                 170                 175     
Leu His Leu Thr Cys Pro His Tyr Trp Arg Tyr Gly Glu Glu Gly Glu 
            180                 185                 190         
Thr Glu Glu Gln Phe Val Ala Arg Leu Ala His Glu Leu Glu Glu Thr 
        195                 200                 205             
Ile Gln Lys Glu Gly Ala Asp Thr Ile Ala Gly Phe Phe Ala Glu Pro 
    210                 215                 220                 
Val Met Gly Ala Gly Gly Val Ile Pro Pro Ala Lys Gly Tyr Phe Gln 
225                 230                 235                 240 
Ala Ile Leu Pro Ile Leu Arg Lys Tyr Asp Ile Pro Val Ile Ser Asp 
                245                 250                 255     
Glu Val Ile Thr Gly Phe Gly Arg Thr Gly Asn Thr Trp Gly Cys Val 
            260                 265                 270         
Thr Tyr Asp Phe Thr Pro Asp Ala Ile Ile Ser Ala Lys Gly Leu Thr 
        275                 280                 285             
Ala Gly Phe Phe Ala Val Gly Ala Val Ile Leu Gly Pro Glu Leu Ser 
    290                 295                 300                 
Lys Arg Leu Glu Thr Ala Ile Glu Leu Arg Glu Trp Phe Pro His Ala 
305                 310                 315                 320 
Phe Thr Thr Gly Gly His Pro Val Gly Cys Ala Ile Ala Leu Lys Ala 
                325                 330                 335     
Ile Asp Val Val Met Asn Glu Gly Leu Ala Glu Asn Val Arg Arg Leu 
            340                 345                 350         
Ala Pro Arg Phe Glu Glu Arg Leu Lys His Ile Ala Glu Arg Pro Asn 
        355                 360                 365             
Ile Gly Glu Tyr Arg Gly Ile Gly Phe Met Trp Ala Leu Glu Val Val 
    370                 375                 380                 
Lys Asp Lys Ala Ser Lys Ala Pro Phe Pro Gly Asn Leu Ser Val Ser 
385                 390                 395                 400 
Glu Arg Ile Ala Asn Thr Cys Thr Asp Leu Gly Leu Ile Val Arg Ala 
                405                 410                 415     
Leu Gly Gln Ser Val Ala Leu Ala Pro Pro Phe Ile Leu Thr Glu Ala 
            420                 425                 430         
Gln Met Asp Glu Met Phe Asp Lys Leu Glu Lys Ala Leu Asp Lys Val 
        435                 440                 445             
Phe Ala Glu Val Ala                                             
    450                                                         

 
<210> 157
<211> 1359
<212> DNA
<213> Artificial Sequence
 
<220>
<223> variant of transaminase from Vibrio fluvialis Js17
 
<400> 157
atgaacaaac cgcagagctg ggaaacgcgt gcggaaacct atagcctgat gggtcatacc 60
gatatgccga gcctgcatca gcgtggcacc atggtggtga cccatggcga aggcccgtat 120
atcgtggatg tgcatggccg tcgttatctg gatgcgtgca gcggcgctgc gaacatggtg 180
gcgggctttg atcataaagg cctgattgat gcggcgaaaa cgcagtatga acgttttccg 240
ggctatcacg cggttaatgg ccgtatgagc gatcagaccg tgatgctgtc tgaaaaactg 300
gtggaagtga gcccgtttga tagcggccgt gtgttttata ccaacagcgg cagcgaagcg 360
aacgatacca tggtgaaaat gctgtggttt ctgcatgcgg cggaaggcaa accgcagaaa 420
cgtaaaattc tgacccattg gaacgcgtat catggcgcga ccgcggtgag cgcgagcatg 480
accggctttc cgtggaacag cgtgtttggc ctgccgctgc cgggctttct gcatctgacc 540
tgcccgcatt attggcgtta tggcgaagaa ggcgaaaccg aagaacagtt tgtcgcgcgt 600
ctggcccatg aactggaaga aaccattcag aaggaaggcg cggataccat tgcgggcttt 660
tttgcggaac cggtgatggg tgcgggcggt gttattccgc cggcaaaagg ctattttcag 720
gcgattctgc cgatcctgcg caaatatgat attccggtga tctccgatga agtgattacc 780
ggcttcggcc gtaccggtaa cacctggggc tgcgtaacct atgattttac cccggatgcg 840
attattagcg cgaaaggcct aaccgcgggt ttttttgcgg taggcgcggt gattctgggt 900
ccggaactga gcaaacgtct ggaaaccgcg attgaactgc gtgaatggtt tccgcatgct 960
tttaccacag gtggccatcc ggtgggttgt gcgattgcgc tgaaagcgat tgatgtggtg 1020
atgaacgaag gcctggccga aaacgtgcgt cgtctggccc cgcgttttga agaacgtctg 1080
aaacatattg cggaacgtcc gaacattggc gaatatcgtg gcattggctt tatgtgggcg 1140
ctggaagtcg tgaaagataa agcgagcaaa gccccgtttc ccggcaacct gagcgtgagc 1200
gaacgtattg cgaacacctg caccgatctg ggcctgattg tgcgtgcgct gggccagagc 1260
gtggcgctgg cgccgccgtt tattctgacc gaagcgcaga tggatgaaat gttcgataaa 1320
ctggaaaaag cgctggataa agtgttcgcg gaagtggcg                        1359

 
<210> 158
<211> 453
<212> PRT
<213> Artificial Sequence
 
<220>
<223> variant of transaminase from Vibrio fluvialis Js17
 
<400> 158
Met Asn Lys Pro Gln Ser Trp Glu Thr Arg Ala Glu Thr Tyr Ser Leu 
1               5                   10                  15      
Met Gly His Thr Asp Met Pro Ser Leu His Gln Arg Gly Thr Met Val 
            20                  25                  30          
Val Thr His Gly Glu Gly Pro Tyr Ile Val Asp Val His Gly Arg Arg 
        35                  40                  45              
Tyr Leu Asp Ala Cys Ser Gly Ala Ala Asn Met Val Ala Gly Phe Asp 
    50                  55                  60                  
His Lys Gly Leu Ile Asp Ala Ala Lys Thr Gln Tyr Glu Arg Phe Pro 
65                  70                  75                  80  
Gly Tyr His Ala Val Asn Gly Arg Met Ser Asp Gln Thr Val Met Leu 
                85                  90                  95      
Ser Glu Lys Leu Val Glu Val Ser Pro Phe Asp Ser Gly Arg Val Phe 
            100                 105                 110         
Tyr Thr Asn Ser Gly Ser Glu Ala Asn Asp Thr Met Val Lys Met Leu 
        115                 120                 125             
Trp Phe Leu His Ala Ala Glu Gly Lys Pro Gln Lys Arg Lys Ile Leu 
    130                 135                 140                 
Thr His Trp Asn Ala Tyr His Gly Ala Thr Ala Val Ser Ala Ser Met 
145                 150                 155                 160 
Thr Gly Phe Pro Trp Asn Ser Val Phe Gly Leu Pro Leu Pro Gly Phe 
                165                 170                 175     
Leu His Leu Thr Cys Pro His Tyr Trp Arg Tyr Gly Glu Glu Gly Glu 
            180                 185                 190         
Thr Glu Glu Gln Phe Val Ala Arg Leu Ala His Glu Leu Glu Glu Thr 
        195                 200                 205             
Ile Gln Lys Glu Gly Ala Asp Thr Ile Ala Gly Phe Phe Ala Glu Pro 
    210                 215                 220                 
Val Met Gly Ala Gly Gly Val Ile Pro Pro Ala Lys Gly Tyr Phe Gln 
225                 230                 235                 240 
Ala Ile Leu Pro Ile Leu Arg Lys Tyr Asp Ile Pro Val Ile Ser Asp 
                245                 250                 255     
Glu Val Ile Thr Gly Phe Gly Arg Thr Gly Asn Thr Trp Gly Cys Val 
            260                 265                 270         
Thr Tyr Asp Phe Thr Pro Asp Ala Ile Ile Ser Ala Lys Gly Leu Thr 
        275                 280                 285             
Ala Gly Phe Phe Ala Val Gly Ala Val Ile Leu Gly Pro Glu Leu Ser 
    290                 295                 300                 
Lys Arg Leu Glu Thr Ala Ile Glu Leu Arg Glu Trp Phe Pro His Ala 
305                 310                 315                 320 
Phe Thr Thr Gly Gly His Pro Val Gly Cys Ala Ile Ala Leu Lys Ala 
                325                 330                 335     
Ile Asp Val Val Met Asn Glu Gly Leu Ala Glu Asn Val Arg Arg Leu 
            340                 345                 350         
Ala Pro Arg Phe Glu Glu Arg Leu Lys His Ile Ala Glu Arg Pro Asn 
        355                 360                 365             
Ile Gly Glu Tyr Arg Gly Ile Gly Phe Met Trp Ala Leu Glu Val Val 
    370                 375                 380                 
Lys Asp Lys Ala Ser Lys Ala Pro Phe Pro Gly Asn Leu Ser Val Ser 
385                 390                 395                 400 
Glu Arg Ile Ala Asn Thr Cys Thr Asp Leu Gly Leu Ile Val Arg Ala 
                405                 410                 415     
Leu Gly Gln Ser Val Ala Leu Ala Pro Pro Phe Ile Leu Thr Glu Ala 
            420                 425                 430         
Gln Met Asp Glu Met Phe Asp Lys Leu Glu Lys Ala Leu Asp Lys Val 
        435                 440                 445             
Phe Ala Glu Val Ala                                             
    450                                                         

 
<210> 159
<211> 1359
<212> DNA
<213> Artificial Sequence
 
<220>
<223> variant of transaminase from Vibrio fluvialis Js17
 
<400> 159
atgaacaaac cgcagagctg ggaaacgcgt gcggaaacct atagcctgat gggtcatacc 60
gatatgccga gcctgcatca gcgtggcacc atggtggtga cccatggcga aggcccgtat 120
atcgtggatg tgcatggccg tcgttatctg gatgcgtgca gcggcgctgc gaacatggtg 180
gcgggctttg atcataaagg cctgattgat gcggcgaaaa cgcagtatga acgttttccg 240
ggctatcacg cggttaatgg ccgtatgagc gatcagaccg tgatgctgtc tgaaaaactg 300
gtggaagtga gcccgtttga tagcggccgt gtgttttata ccaacagcgg cagcgaagcg 360
aacgatacca tggtgaaaat gctgtggttt ctgcatgcgg cggaaggcaa accgcagaaa 420
cgtaaaattc tgacccattg gaacgcgtat catggcgcga ccgcggtgag cgcgagcatg 480
accggctttc cgtataacag cgtgtttggc ctgccgctgc cgggctttct gcatctgacc 540
tgcccgcatt attggcgtta tggcgaaccc ggcgaaaccg aagaacagtt tgtcgcgcgt 600
ctggcccatg aactggaaga taccattgca aaggaaggcg cggataccat tgcgggcttt 660
tttgcggaac cggtgatggg tgcgggcggt gttattccgc cggcaaaagg ctattttcag 720
gcgattctgc cgatcctgcg caaatatgat attccggtga tctccgatga agtgattacc 780
ggcttcggcc gtaccggtaa cacctggggc tgcgtgacct atgattttac cccggatgcg 840
attattagcg cgaaaggcct aaccgcgggt ttttttgcgg taggcgcggt gattctgggt 900
ccggaactga gcaaacgtct ggaaaccgcg attgaactgc gtgaatggtt tccgcatgct 960
tttaccacag gtggccatcc ggtgggttgt gcgattgcgc tgaaagcgat tgatgtggtg 1020
atgaacgaag gcctggccga aaacgtgcgt cgtctggccc cgcgttttga agaacgtctg 1080
aaacatattg cggaacgtcc gaacattggc gaatatcgtg gcattggctt tatgtgggcg 1140
ctggaagtcg tgaaggataa agcgagcaaa gccccgtttg gtggcaacct gagcgtgagc 1200
gaacgtattg cgaacacctg caccgatctg ggcctgattg tgcgtgcgct gggccagagc 1260
gtggcgctgg cgccgccgtt tattctgacc gaagcgcaga tggatgaaat gttcgataaa 1320
ctggaaaaag cgctggataa agtgttcgcg gaagtggcg                        1359

 
<210> 160
<211> 453
<212> PRT
<213> Artificial Sequence
 
<220>
<223> variant of transaminase from Vibrio fluvialis Js17
 
<400> 160
Met Asn Lys Pro Gln Ser Trp Glu Thr Arg Ala Glu Thr Tyr Ser Leu 
1               5                   10                  15      
Met Gly His Thr Asp Met Pro Ser Leu His Gln Arg Gly Thr Met Val 
            20                  25                  30          
Val Thr His Gly Glu Gly Pro Tyr Ile Val Asp Val His Gly Arg Arg 
        35                  40                  45              
Tyr Leu Asp Ala Cys Ser Gly Ala Ala Asn Met Val Ala Gly Phe Asp 
    50                  55                  60                  
His Lys Gly Leu Ile Asp Ala Ala Lys Thr Gln Tyr Glu Arg Phe Pro 
65                  70                  75                  80  
Gly Tyr His Ala Val Asn Gly Arg Met Ser Asp Gln Thr Val Met Leu 
                85                  90                  95      
Ser Glu Lys Leu Val Glu Val Ser Pro Phe Asp Ser Gly Arg Val Phe 
            100                 105                 110         
Tyr Thr Asn Ser Gly Ser Glu Ala Asn Asp Thr Met Val Lys Met Leu 
        115                 120                 125             
Trp Phe Leu His Ala Ala Glu Gly Lys Pro Gln Lys Arg Lys Ile Leu 
    130                 135                 140                 
Thr His Trp Asn Ala Tyr His Gly Ala Thr Ala Val Ser Ala Ser Met 
145                 150                 155                 160 
Thr Gly Phe Pro Tyr Asn Ser Val Phe Gly Leu Pro Leu Pro Gly Phe 
                165                 170                 175     
Leu His Leu Thr Cys Pro His Tyr Trp Arg Tyr Gly Glu Pro Gly Glu 
            180                 185                 190         
Thr Glu Glu Gln Phe Val Ala Arg Leu Ala His Glu Leu Glu Asp Thr 
        195                 200                 205             
Ile Ala Lys Glu Gly Ala Asp Thr Ile Ala Gly Phe Phe Ala Glu Pro 
    210                 215                 220                 
Val Met Gly Ala Gly Gly Val Ile Pro Pro Ala Lys Gly Tyr Phe Gln 
225                 230                 235                 240 
Ala Ile Leu Pro Ile Leu Arg Lys Tyr Asp Ile Pro Val Ile Ser Asp 
                245                 250                 255     
Glu Val Ile Thr Gly Phe Gly Arg Thr Gly Asn Thr Trp Gly Cys Val 
            260                 265                 270         
Thr Tyr Asp Phe Thr Pro Asp Ala Ile Ile Ser Ala Lys Gly Leu Thr 
        275                 280                 285             
Ala Gly Phe Phe Ala Val Gly Ala Val Ile Leu Gly Pro Glu Leu Ser 
    290                 295                 300                 
Lys Arg Leu Glu Thr Ala Ile Glu Leu Arg Glu Trp Phe Pro His Ala 
305                 310                 315                 320 
Phe Thr Thr Gly Gly His Pro Val Gly Cys Ala Ile Ala Leu Lys Ala 
                325                 330                 335     
Ile Asp Val Val Met Asn Glu Gly Leu Ala Glu Asn Val Arg Arg Leu 
            340                 345                 350         
Ala Pro Arg Phe Glu Glu Arg Leu Lys His Ile Ala Glu Arg Pro Asn 
        355                 360                 365             
Ile Gly Glu Tyr Arg Gly Ile Gly Phe Met Trp Ala Leu Glu Val Val 
    370                 375                 380                 
Lys Asp Lys Ala Ser Lys Ala Pro Phe Gly Gly Asn Leu Ser Val Ser 
385                 390                 395                 400 
Glu Arg Ile Ala Asn Thr Cys Thr Asp Leu Gly Leu Ile Val Arg Ala 
                405                 410                 415     
Leu Gly Gln Ser Val Ala Leu Ala Pro Pro Phe Ile Leu Thr Glu Ala 
            420                 425                 430         
Gln Met Asp Glu Met Phe Asp Lys Leu Glu Lys Ala Leu Asp Lys Val 
        435                 440                 445             
Phe Ala Glu Val Ala                                             
    450                                                         

 
<210> 161
<211> 1359
<212> DNA
<213> Artificial Sequence
 
<220>
<223> variant of transaminase from Vibrio fluvialis Js17
 
<400> 161
atgaacaaac cgcagagctg ggaaacgcgt gcggaaacct atagcctgat gggtcatacc 60
gatatgccga ccctgcatca gcgtggcacc atggtggtga cccatggcga aggcccgtat 120
atcgtggatg tgcatggccg tcgttatctg gatgcgtgca gcggcgctgc gaacatggtg 180
gcgggctttg atcataaagg cctgattgat gcggcgaaaa cgcagtatga acgttttccg 240
ggctatcacg cggttaatgg ccgtatgagc gatcagaccg tgatgctgtc tgaaaaactg 300
gtggaagtga gcccgtttga tagcggccgt gtgttttata ccaacagcgg cagcgaagcg 360
aacgatacca tggtgaaaat gctgtggttt ctgcatgcgg cggaaggcaa accgcagaaa 420
cgtaaaattc tgacccattg gaacgcgtat catggcgcga ccgcggtgag cgcgagcatg 480
accggctttc cgtataacag cgtgtttggc ctgccgctgc cgggctttct gcatctgacc 540
tgcccgcatt attggcgtta tggcgaagaa ggcgaaaccg aagaacagtt tgtcgcgcgt 600
ctggcccatg aactggaaga aaccattcag aaggaaggcg cggataccat tgcgggcttt 660
tttgcggaac cggtgatggg tgcgggcggt gttattccgc cggcaaaagg ctattttcag 720
gcgattctgc cgatcctgcg caaatatgat attccggtga tctccgatga agtgattacc 780
ggcttcggcc gtaccggtaa cacctggggc tgcgtgacct atgattttac cccggatgcg 840
attattagcg cgaaaggcct aaccgcgggt ttttttgcgg taggcgcggt gattctgggt 900
ccggaactga gcaaacgtct ggaaaccgcg atcgaactgc gtgaatggtt tccgcatgct 960
tttaccacag gtggccatcc ggtgggttgt gcgattgcgc tgaaagcgat tgatgtggtg 1020
atgaacgaag gcctggccga aaacgtgcgt cgtctggccc cgcgttttga agaacgtctg 1080
aaacatattg cggaacgtcc gaacattggc gaatatcgtg gcattggctt tatgtgggcg 1140
ctggaagtcg tgaaagataa agcgagcaaa gccccgtttg gtggcaacct gagcgtgagc 1200
gaacgtattg cgaacacctg caccgatctg ggcctgattg tgcgtgcgct gggccagagc 1260
gtggcgctgg cgccgccgtt tattctgacc gaagcgcaga tggatgaaat gttcgataaa 1320
ctggaaaaag cgctggataa agtgttcgcg gaagtggcg                        1359

 
<210> 162
<211> 453
<212> PRT
<213> Artificial Sequence
 
<220>
<223> variant of transaminase from Vibrio fluvialis Js17
 
<400> 162
Met Asn Lys Pro Gln Ser Trp Glu Thr Arg Ala Glu Thr Tyr Ser Leu 
1               5                   10                  15      
Met Gly His Thr Asp Met Pro Thr Leu His Gln Arg Gly Thr Met Val 
            20                  25                  30          
Val Thr His Gly Glu Gly Pro Tyr Ile Val Asp Val His Gly Arg Arg 
        35                  40                  45              
Tyr Leu Asp Ala Cys Ser Gly Ala Ala Asn Met Val Ala Gly Phe Asp 
    50                  55                  60                  
His Lys Gly Leu Ile Asp Ala Ala Lys Thr Gln Tyr Glu Arg Phe Pro 
65                  70                  75                  80  
Gly Tyr His Ala Val Asn Gly Arg Met Ser Asp Gln Thr Val Met Leu 
                85                  90                  95      
Ser Glu Lys Leu Val Glu Val Ser Pro Phe Asp Ser Gly Arg Val Phe 
            100                 105                 110         
Tyr Thr Asn Ser Gly Ser Glu Ala Asn Asp Thr Met Val Lys Met Leu 
        115                 120                 125             
Trp Phe Leu His Ala Ala Glu Gly Lys Pro Gln Lys Arg Lys Ile Leu 
    130                 135                 140                 
Thr His Trp Asn Ala Tyr His Gly Ala Thr Ala Val Ser Ala Ser Met 
145                 150                 155                 160 
Thr Gly Phe Pro Tyr Asn Ser Val Phe Gly Leu Pro Leu Pro Gly Phe 
                165                 170                 175     
Leu His Leu Thr Cys Pro His Tyr Trp Arg Tyr Gly Glu Glu Gly Glu 
            180                 185                 190         
Thr Glu Glu Gln Phe Val Ala Arg Leu Ala His Glu Leu Glu Glu Thr 
        195                 200                 205             
Ile Gln Lys Glu Gly Ala Asp Thr Ile Ala Gly Phe Phe Ala Glu Pro 
    210                 215                 220                 
Val Met Gly Ala Gly Gly Val Ile Pro Pro Ala Lys Gly Tyr Phe Gln 
225                 230                 235                 240 
Ala Ile Leu Pro Ile Leu Arg Lys Tyr Asp Ile Pro Val Ile Ser Asp 
                245                 250                 255     
Glu Val Ile Thr Gly Phe Gly Arg Thr Gly Asn Thr Trp Gly Cys Val 
            260                 265                 270         
Thr Tyr Asp Phe Thr Pro Asp Ala Ile Ile Ser Ala Lys Gly Leu Thr 
        275                 280                 285             
Ala Gly Phe Phe Ala Val Gly Ala Val Ile Leu Gly Pro Glu Leu Ser 
    290                 295                 300                 
Lys Arg Leu Glu Thr Ala Ile Glu Leu Arg Glu Trp Phe Pro His Ala 
305                 310                 315                 320 
Phe Thr Thr Gly Gly His Pro Val Gly Cys Ala Ile Ala Leu Lys Ala 
                325                 330                 335     
Ile Asp Val Val Met Asn Glu Gly Leu Ala Glu Asn Val Arg Arg Leu 
            340                 345                 350         
Ala Pro Arg Phe Glu Glu Arg Leu Lys His Ile Ala Glu Arg Pro Asn 
        355                 360                 365             
Ile Gly Glu Tyr Arg Gly Ile Gly Phe Met Trp Ala Leu Glu Val Val 
    370                 375                 380                 
Lys Asp Lys Ala Ser Lys Ala Pro Phe Gly Gly Asn Leu Ser Val Ser 
385                 390                 395                 400 
Glu Arg Ile Ala Asn Thr Cys Thr Asp Leu Gly Leu Ile Val Arg Ala 
                405                 410                 415     
Leu Gly Gln Ser Val Ala Leu Ala Pro Pro Phe Ile Leu Thr Glu Ala 
            420                 425                 430         
Gln Met Asp Glu Met Phe Asp Lys Leu Glu Lys Ala Leu Asp Lys Val 
        435                 440                 445             
Phe Ala Glu Val Ala                                             
    450                                                         

 
<210> 163
<211> 1359
<212> DNA
<213> Artificial Sequence
 
<220>
<223> variant of transaminase from Vibrio fluvialis Js17
 
<400> 163
atgaacaaac cgcagagctg ggaaacgcgt gcggaaacct atagcctgat gggtcatacc 60
gatatgccga gcctgcatca gcgtggcacc atggtggtga cccatggcga aggcccgtat 120
atttttgatg tgcatggccg tcgttatctg gatgcgtgca gcggcgctgc gaacatggtg 180
gcgggctttg atcatccagg cctgattgat gcggcgaaaa cgcagtatga acgttttccg 240
ggctatcacg cggttaatgg ccgtatgagc gatcagaccg tgatgctgtc tgaaaaactg 300
gtggaagtga gcccgtttga tagcggccgt gtgttttata ccaacagcgg cagcgaagcg 360
aacgatacca tggtgaaaat gctgtggttt ctgcatgcgg cggaaggcaa accgcagaaa 420
cgtaaaattc tgacccattg gaacgcgtat catggcgcga ccgcggtgag cgcgagcatg 480
accggctttc cgtgggggag cgtgtttggc ctgccgctgc cgggctttct gcatctgacc 540
tgcccgcatt attggcgtta tggcgaagaa ggcgaaaccg aagaacagtt tgtcgcgcgt 600
ctggcccatg aactggaaga aaccattcag aaggaaggcg cggataccat tgcgggcttt 660
tttgcggaac cggtgatggg tgcgggcggt gttattccgc cggcaaaagg ctattttcag 720
gcgattctgc cgatcctgcg caaatatgat attccggtga tctccgatga agtgattacc 780
ggcttcggcc gtaccggtaa cacctggggc tgcgtaacct atgattttac cccggatgcg 840
attattagcg cgaaaggcct aaccgcgggt ttttttgcgg taggcgcggt gattctgggt 900
ccggaactga gcaaacgtct ggaaaccgcg attgaactgc gtgaatggtt tccgcatgct 960
tttaccacag gtggccatcc ggtgggttgt gcgattgcgc tgaaagcgat tgatgtggtg 1020
atgaacgaag gcctggccga aaacgtgcgt cgtctggccc cgcgttttga agaacgtctg 1080
aaacatattg cggaacgtcc gaacattggc gaatatcgtg gcattggctt tatgtgggcg 1140
ctggaagtcg tgaaagataa agcgagcaaa gccccgtttc ccggcaacct gagcgtgagc 1200
gaacgtattg cgaacacctg caccgatctg ggcctgattg tgcgtgcgct gggccagagc 1260
gtggcgctgg cgccgccgtt tattctgacc gaagcgcaga tggatgaaat gttcgataaa 1320
ctggaaaaag cgctggataa agtgttcgcg gaagtggcg                        1359

 
<210> 164
<211> 453
<212> PRT
<213> Artificial Sequence
 
<220>
<223> variant of transaminase from Vibrio fluvialis Js17
 
<400> 164
Met Asn Lys Pro Gln Ser Trp Glu Thr Arg Ala Glu Thr Tyr Ser Leu 
1               5                   10                  15      
Met Gly His Thr Asp Met Pro Ser Leu His Gln Arg Gly Thr Met Val 
            20                  25                  30          
Val Thr His Gly Glu Gly Pro Tyr Ile Phe Asp Val His Gly Arg Arg 
        35                  40                  45              
Tyr Leu Asp Ala Cys Ser Gly Ala Ala Asn Met Val Ala Gly Phe Asp 
    50                  55                  60                  
His Pro Gly Leu Ile Asp Ala Ala Lys Thr Gln Tyr Glu Arg Phe Pro 
65                  70                  75                  80  
Gly Tyr His Ala Val Asn Gly Arg Met Ser Asp Gln Thr Val Met Leu 
                85                  90                  95      
Ser Glu Lys Leu Val Glu Val Ser Pro Phe Asp Ser Gly Arg Val Phe 
            100                 105                 110         
Tyr Thr Asn Ser Gly Ser Glu Ala Asn Asp Thr Met Val Lys Met Leu 
        115                 120                 125             
Trp Phe Leu His Ala Ala Glu Gly Lys Pro Gln Lys Arg Lys Ile Leu 
    130                 135                 140                 
Thr His Trp Asn Ala Tyr His Gly Ala Thr Ala Val Ser Ala Ser Met 
145                 150                 155                 160 
Thr Gly Phe Pro Trp Gly Ser Val Phe Gly Leu Pro Leu Pro Gly Phe 
                165                 170                 175     
Leu His Leu Thr Cys Pro His Tyr Trp Arg Tyr Gly Glu Glu Gly Glu 
            180                 185                 190         
Thr Glu Glu Gln Phe Val Ala Arg Leu Ala His Glu Leu Glu Glu Thr 
        195                 200                 205             
Ile Gln Lys Glu Gly Ala Asp Thr Ile Ala Gly Phe Phe Ala Glu Pro 
    210                 215                 220                 
Val Met Gly Ala Gly Gly Val Ile Pro Pro Ala Lys Gly Tyr Phe Gln 
225                 230                 235                 240 
Ala Ile Leu Pro Ile Leu Arg Lys Tyr Asp Ile Pro Val Ile Ser Asp 
                245                 250                 255     
Glu Val Ile Thr Gly Phe Gly Arg Thr Gly Asn Thr Trp Gly Cys Val 
            260                 265                 270         
Thr Tyr Asp Phe Thr Pro Asp Ala Ile Ile Ser Ala Lys Gly Leu Thr 
        275                 280                 285             
Ala Gly Phe Phe Ala Val Gly Ala Val Ile Leu Gly Pro Glu Leu Ser 
    290                 295                 300                 
Lys Arg Leu Glu Thr Ala Ile Glu Leu Arg Glu Trp Phe Pro His Ala 
305                 310                 315                 320 
Phe Thr Thr Gly Gly His Pro Val Gly Cys Ala Ile Ala Leu Lys Ala 
                325                 330                 335     
Ile Asp Val Val Met Asn Glu Gly Leu Ala Glu Asn Val Arg Arg Leu 
            340                 345                 350         
Ala Pro Arg Phe Glu Glu Arg Leu Lys His Ile Ala Glu Arg Pro Asn 
        355                 360                 365             
Ile Gly Glu Tyr Arg Gly Ile Gly Phe Met Trp Ala Leu Glu Val Val 
    370                 375                 380                 
Lys Asp Lys Ala Ser Lys Ala Pro Phe Pro Gly Asn Leu Ser Val Ser 
385                 390                 395                 400 
Glu Arg Ile Ala Asn Thr Cys Thr Asp Leu Gly Leu Ile Val Arg Ala 
                405                 410                 415     
Leu Gly Gln Ser Val Ala Leu Ala Pro Pro Phe Ile Leu Thr Glu Ala 
            420                 425                 430         
Gln Met Asp Glu Met Phe Asp Lys Leu Glu Lys Ala Leu Asp Lys Val 
        435                 440                 445             
Phe Ala Glu Val Ala                                             
    450                                                         

 
<210> 165
<211> 1359
<212> DNA
<213> Artificial Sequence
 
<220>
<223> variant of transaminase from Vibrio fluvialis Js17
 
<400> 165
atgaacaaac cgcagagctg ggaaacgcgt gcggaaacct atagcctgat gggtcatacc 60
gatatgccga gcctgcatca gcgtggcacc atggtggtga cccatggcga aggcccgtat 120
atttttgatg tgcatggccg tcgttatctg gatgcgtgca gcggcgctgc gaacatggtg 180
gcgggctttg atcatccagg cctgattgat gcggcgaaaa cgcagtatga acgttttccg 240
ggctatcacg cggttaatgg ccgtatgagc gatcagaccg tgatgctgtc tgaaaaactg 300
gtggaagtga gcccgtttga tagcggccgt gtgttttata ccaacagcgg cagcgaagcg 360
aacgatacca tggtgaaaat gctgtggttt ctgcatgcgg cggaaggcaa accgcagaaa 420
cgtaaaattc tgacccattg gaacgcgtat catggcgcga ccgcggtgag cgcgagcatg 480
accggctttc cgtggaacag cgtgtttggc ctgccgctgc cgggctttct gcatctgacc 540
tgcccgcatt attggcgtta tggcgaagaa ggcgaaaccg aagaacagtt tgtcgcgcgt 600
ctggcccatg aactggaaga aaccattcag aaggaaggcg cggataccat tgcgggcttt 660
tttgcggaac cggtgatggg tgcgggcggt gttattccgc cggcaaaagg ctattttcag 720
gcgattctgc cgatcctgcg caaatatgat attccggtga tctccgatga agtgattacc 780
ggcttcggcc gtaccggtaa cacctggggc tgcgtaacct atgattttac cccggatgcg 840
attattagcg cgaaaggcct aaccgcgggt tattttgcgg taggcgcggt gattctgggt 900
ccggaactgt cgaaacgtct ggaagccgcg attgaactgc gtgaatggtt tccgcatgct 960
tttaccacag gtggccatcc ggtgggttgt gcgattgcgc tgaaagcgat tgatgtggtg 1020
atgaacgaag gcctggccga aaacgtgcgt cgtctggccc cgcgttttga agaacgtctg 1080
aaacatattg cggaacgtcc gaacattggc gaataccgtg gcattggctt tatgtgggcg 1140
ctggaagtcg tgaaagataa agcgagcaaa gccccgtttc ccggcaacct gagcgtgagc 1200
gaacgtattg cgaacacctg caccgatctg ggcctgattg tgcgtgcgct gggccagagc 1260
gtggcgctgg cgccgccgtt tattctgacc gaagcgcaga tggatgaaat gttcgataaa 1320
ctggaaaaag cgctggataa agtgttcgcg gaagtggcg                        1359

 
<210> 166
<211> 453
<212> PRT
<213> Artificial Sequence
 
<220>
<223> variant of transaminase from Vibrio fluvialis Js17
 
<400> 166
Met Asn Lys Pro Gln Ser Trp Glu Thr Arg Ala Glu Thr Tyr Ser Leu 
1               5                   10                  15      
Met Gly His Thr Asp Met Pro Ser Leu His Gln Arg Gly Thr Met Val 
            20                  25                  30          
Val Thr His Gly Glu Gly Pro Tyr Ile Phe Asp Val His Gly Arg Arg 
        35                  40                  45              
Tyr Leu Asp Ala Cys Ser Gly Ala Ala Asn Met Val Ala Gly Phe Asp 
    50                  55                  60                  
His Pro Gly Leu Ile Asp Ala Ala Lys Thr Gln Tyr Glu Arg Phe Pro 
65                  70                  75                  80  
Gly Tyr His Ala Val Asn Gly Arg Met Ser Asp Gln Thr Val Met Leu 
                85                  90                  95      
Ser Glu Lys Leu Val Glu Val Ser Pro Phe Asp Ser Gly Arg Val Phe 
            100                 105                 110         
Tyr Thr Asn Ser Gly Ser Glu Ala Asn Asp Thr Met Val Lys Met Leu 
        115                 120                 125             
Trp Phe Leu His Ala Ala Glu Gly Lys Pro Gln Lys Arg Lys Ile Leu 
    130                 135                 140                 
Thr His Trp Asn Ala Tyr His Gly Ala Thr Ala Val Ser Ala Ser Met 
145                 150                 155                 160 
Thr Gly Phe Pro Trp Asn Ser Val Phe Gly Leu Pro Leu Pro Gly Phe 
                165                 170                 175     
Leu His Leu Thr Cys Pro His Tyr Trp Arg Tyr Gly Glu Glu Gly Glu 
            180                 185                 190         
Thr Glu Glu Gln Phe Val Ala Arg Leu Ala His Glu Leu Glu Glu Thr 
        195                 200                 205             
Ile Gln Lys Glu Gly Ala Asp Thr Ile Ala Gly Phe Phe Ala Glu Pro 
    210                 215                 220                 
Val Met Gly Ala Gly Gly Val Ile Pro Pro Ala Lys Gly Tyr Phe Gln 
225                 230                 235                 240 
Ala Ile Leu Pro Ile Leu Arg Lys Tyr Asp Ile Pro Val Ile Ser Asp 
                245                 250                 255     
Glu Val Ile Thr Gly Phe Gly Arg Thr Gly Asn Thr Trp Gly Cys Val 
            260                 265                 270         
Thr Tyr Asp Phe Thr Pro Asp Ala Ile Ile Ser Ala Lys Gly Leu Thr 
        275                 280                 285             
Ala Gly Tyr Phe Ala Val Gly Ala Val Ile Leu Gly Pro Glu Leu Ser 
    290                 295                 300                 
Lys Arg Leu Glu Ala Ala Ile Glu Leu Arg Glu Trp Phe Pro His Ala 
305                 310                 315                 320 
Phe Thr Thr Gly Gly His Pro Val Gly Cys Ala Ile Ala Leu Lys Ala 
                325                 330                 335     
Ile Asp Val Val Met Asn Glu Gly Leu Ala Glu Asn Val Arg Arg Leu 
            340                 345                 350         
Ala Pro Arg Phe Glu Glu Arg Leu Lys His Ile Ala Glu Arg Pro Asn 
        355                 360                 365             
Ile Gly Glu Tyr Arg Gly Ile Gly Phe Met Trp Ala Leu Glu Val Val 
    370                 375                 380                 
Lys Asp Lys Ala Ser Lys Ala Pro Phe Pro Gly Asn Leu Ser Val Ser 
385                 390                 395                 400 
Glu Arg Ile Ala Asn Thr Cys Thr Asp Leu Gly Leu Ile Val Arg Ala 
                405                 410                 415     
Leu Gly Gln Ser Val Ala Leu Ala Pro Pro Phe Ile Leu Thr Glu Ala 
            420                 425                 430         
Gln Met Asp Glu Met Phe Asp Lys Leu Glu Lys Ala Leu Asp Lys Val 
        435                 440                 445             
Phe Ala Glu Val Ala                                             
    450                                                         

 
<210> 167
<211> 1359
<212> DNA
<213> Artificial Sequence
 
<220>
<223> variant of transaminase from Vibrio fluvialis Js17
 
<400> 167
atgaacaaac cgcagagctg ggaaacgcgt gcggaaacct atagcctgat gggtcatacc 60
gatatgccga gcctgcatca gcgtggcacc atggtggtga cccatggcga aggcccgtat 120
atttttgatg tgcatggccg tcgttatctg gatgcgtgca gcggcgctgc gaacatggtg 180
gcgggctttg atcatccagg cctgattgat gcggcgaaaa cgcagtatga acgttttccg 240
ggctatcacg cggttaatgg ccgtatgagc gatcagaccg tgatgctgtc tgaaaaactg 300
gtggaagtga gcccgtttga tagcggccgt gtgttttata ccaacagcgg cagcgaagcg 360
aacgatacca tggtgaaaat gctgtggttt ctgcatgcgg cggaaggcaa accgcagaaa 420
cgtaaaattc tgacccattg gaacgcgtat catggcgcga ccgcggtgag cgcgagcatg 480
accggctttc cgtgggccag cgtgtttggc ctgccgctgc cgggctttct gcatctgacc 540
tgcccgcatt attggcgtta tggcgaagag ggcgaaaccg aagaacagtt tgtcgcgcgt 600
ctggcccatg aactggaaga taccattcag aaggaaggcg cggataccat tgcgggcttt 660
tttgcggaac cggtgatggg tgcgggcggt gttattccgc cggcaaaagg ctattttcag 720
gcgattctgc cgatcctgcg caaatatgat attccggtga tctccgatga agtgattacc 780
ggcttcggcc gtaccggtaa cacctggggc tgcgtaacct atgattttac cccggatgcg 840
attattagcg cgaaaggcct aaccgcgggt ttttttgcgg taggcgcggt gattctgggt 900
ccggaactga gcaaacgtct ggaaaccgcg attgaactgc gtgaatggtt tccgcatgct 960
tttaccacag gtggccatcc ggtgggttgt gcgattgcgc tgaaagcgat tgatgtggtg 1020
atgaacgaag gcctggccga aaacgtgcgt cgtctggccc cgcgttttga agaacgtctg 1080
aaacatattg cggaacgtcc gaacattggc gaatatcgtg gcattggctt tatgtgggcg 1140
ctggaagtcg tgaaagataa agcgagcaaa gccccgtttc ccggcaacct gagcgtgagc 1200
gaacgtattg cgaacacctg caccgatctg ggcctgattg tgcgtgcgct gggccagagc 1260
gtggcgctgg cgccgccgtt tattctgacc gaagcgcaga tggatgaaat gttcgataaa 1320
ctggaaaaag cgctggataa agtgttcgcg gaagtggcg                        1359

 
<210> 168
<211> 453
<212> PRT
<213> Artificial Sequence
 
<220>
<223> variant of transaminase from Vibrio fluvialis Js17
 
<400> 168
Met Asn Lys Pro Gln Ser Trp Glu Thr Arg Ala Glu Thr Tyr Ser Leu 
1               5                   10                  15      
Met Gly His Thr Asp Met Pro Ser Leu His Gln Arg Gly Thr Met Val 
            20                  25                  30          
Val Thr His Gly Glu Gly Pro Tyr Ile Phe Asp Val His Gly Arg Arg 
        35                  40                  45              
Tyr Leu Asp Ala Cys Ser Gly Ala Ala Asn Met Val Ala Gly Phe Asp 
    50                  55                  60                  
His Pro Gly Leu Ile Asp Ala Ala Lys Thr Gln Tyr Glu Arg Phe Pro 
65                  70                  75                  80  
Gly Tyr His Ala Val Asn Gly Arg Met Ser Asp Gln Thr Val Met Leu 
                85                  90                  95      
Ser Glu Lys Leu Val Glu Val Ser Pro Phe Asp Ser Gly Arg Val Phe 
            100                 105                 110         
Tyr Thr Asn Ser Gly Ser Glu Ala Asn Asp Thr Met Val Lys Met Leu 
        115                 120                 125             
Trp Phe Leu His Ala Ala Glu Gly Lys Pro Gln Lys Arg Lys Ile Leu 
    130                 135                 140                 
Thr His Trp Asn Ala Tyr His Gly Ala Thr Ala Val Ser Ala Ser Met 
145                 150                 155                 160 
Thr Gly Phe Pro Trp Ala Ser Val Phe Gly Leu Pro Leu Pro Gly Phe 
                165                 170                 175     
Leu His Leu Thr Cys Pro His Tyr Trp Arg Tyr Gly Glu Glu Gly Glu 
            180                 185                 190         
Thr Glu Glu Gln Phe Val Ala Arg Leu Ala His Glu Leu Glu Asp Thr 
        195                 200                 205             
Ile Gln Lys Glu Gly Ala Asp Thr Ile Ala Gly Phe Phe Ala Glu Pro 
    210                 215                 220                 
Val Met Gly Ala Gly Gly Val Ile Pro Pro Ala Lys Gly Tyr Phe Gln 
225                 230                 235                 240 
Ala Ile Leu Pro Ile Leu Arg Lys Tyr Asp Ile Pro Val Ile Ser Asp 
                245                 250                 255     
Glu Val Ile Thr Gly Phe Gly Arg Thr Gly Asn Thr Trp Gly Cys Val 
            260                 265                 270         
Thr Tyr Asp Phe Thr Pro Asp Ala Ile Ile Ser Ala Lys Gly Leu Thr 
        275                 280                 285             
Ala Gly Phe Phe Ala Val Gly Ala Val Ile Leu Gly Pro Glu Leu Ser 
    290                 295                 300                 
Lys Arg Leu Glu Thr Ala Ile Glu Leu Arg Glu Trp Phe Pro His Ala 
305                 310                 315                 320 
Phe Thr Thr Gly Gly His Pro Val Gly Cys Ala Ile Ala Leu Lys Ala 
                325                 330                 335     
Ile Asp Val Val Met Asn Glu Gly Leu Ala Glu Asn Val Arg Arg Leu 
            340                 345                 350         
Ala Pro Arg Phe Glu Glu Arg Leu Lys His Ile Ala Glu Arg Pro Asn 
        355                 360                 365             
Ile Gly Glu Tyr Arg Gly Ile Gly Phe Met Trp Ala Leu Glu Val Val 
    370                 375                 380                 
Lys Asp Lys Ala Ser Lys Ala Pro Phe Pro Gly Asn Leu Ser Val Ser 
385                 390                 395                 400 
Glu Arg Ile Ala Asn Thr Cys Thr Asp Leu Gly Leu Ile Val Arg Ala 
                405                 410                 415     
Leu Gly Gln Ser Val Ala Leu Ala Pro Pro Phe Ile Leu Thr Glu Ala 
            420                 425                 430         
Gln Met Asp Glu Met Phe Asp Lys Leu Glu Lys Ala Leu Asp Lys Val 
        435                 440                 445             
Phe Ala Glu Val Ala                                             
    450                                                         

 
<210> 169
<211> 1359
<212> DNA
<213> Artificial Sequence
 
<220>
<223> variant of transaminase from Vibrio fluvialis Js17
 
<400> 169
atgaacaaac cgcagagctg ggaaacgcgt gcggaaacct atagcctgat gggtcatacc 60
gatatgccga gcctgcatca gcgtggcacc atggtggtga cccatggcga aggcccgtat 120
atttttgatg tgcatggccg tcgttatctg gatgcgtgca gcggcgctgc gaacatggtg 180
gcgggctttg atcatccagg cctgattgat gcggcgaaaa cgcagtatga tcgttttccg 240
ggctatcacg cggttaatgg ccgtatgagc gatcagaccg tgatgctgtc tgaaaaactg 300
gtggaagtga gcccgtttga tagcggcaaa gtgttttata ccaacagcgg cagcgaagcg 360
aacgatacca tggtgaaaat gctgtggttt ctgcatgcgg cggaaggcaa accgcagaaa 420
cgtaaaattc tgacccattg gaacgcgtat catggcgcga ccgcggtgag cgcgagcatg 480
accggctttc cgtggaacag cgtgtttggc ctgccgctgc cgggctttct gcatctgacc 540
tgcccgcatt attggcgtta tggcgaagaa ggcgaaaccg aagaacagtt tgtcgcgcgt 600
ctggcccatg aactggaaga aaccattcag aaggaaggcg cggataccat tgcgggcttt 660
tttgcggaac cggtgatggg tgcgggcggt gttattccgc cggcaaaagg ctattttcag 720
gcgattctgc cgatcctgcg caaatatgat attccggtga tctccgatga agtgattacc 780
ggcttcggcc gtaccggtaa cacctggggc tgcgtaacct atgattttac cccggatgcg 840
attattagcg cgaaaggcct aaccgcgggt tattttgcgg taggcgcggt gattctgggt 900
ccggaactgt cgaaacgtct gcaaaccgcg atcgaactgc gtgaatggtt tccgcatgct 960
tttaccacag gtggccatcc ggtgggttgt gcgattgcgc tgaaagcgat tgatgtggtg 1020
atgaacgaag gcctggccga aaacgtgcgt cgtctggccc cgcgttttga agaacgtctg 1080
aaacatattg cggaacgtcc gaacattggc gaatatcgtg gcattggctt tatgtgggcg 1140
ctggaagtcg tgaaagataa agcgagcaaa gccccgtttc ccggcaacct gagcgtgagc 1200
gaacgtattg cgaacacctg caccgatctg ggcctgattg tgcgtgcgct gggccagagc 1260
gtggcgctgg cgccgccgtt tattctgacc gaagcgcaga tggatgaaat gttcgataaa 1320
ctggaaaaag cgctggataa agtgttcgcg gaagtggcg                        1359

 
<210> 170
<211> 453
<212> PRT
<213> Artificial Sequence
 
<220>
<223> variant of transaminase from Vibrio fluvialis Js17
 
<400> 170
Met Asn Lys Pro Gln Ser Trp Glu Thr Arg Ala Glu Thr Tyr Ser Leu 
1               5                   10                  15      
Met Gly His Thr Asp Met Pro Ser Leu His Gln Arg Gly Thr Met Val 
            20                  25                  30          
Val Thr His Gly Glu Gly Pro Tyr Ile Phe Asp Val His Gly Arg Arg 
        35                  40                  45              
Tyr Leu Asp Ala Cys Ser Gly Ala Ala Asn Met Val Ala Gly Phe Asp 
    50                  55                  60                  
His Pro Gly Leu Ile Asp Ala Ala Lys Thr Gln Tyr Asp Arg Phe Pro 
65                  70                  75                  80  
Gly Tyr His Ala Val Asn Gly Arg Met Ser Asp Gln Thr Val Met Leu 
                85                  90                  95      
Ser Glu Lys Leu Val Glu Val Ser Pro Phe Asp Ser Gly Lys Val Phe 
            100                 105                 110         
Tyr Thr Asn Ser Gly Ser Glu Ala Asn Asp Thr Met Val Lys Met Leu 
        115                 120                 125             
Trp Phe Leu His Ala Ala Glu Gly Lys Pro Gln Lys Arg Lys Ile Leu 
    130                 135                 140                 
Thr His Trp Asn Ala Tyr His Gly Ala Thr Ala Val Ser Ala Ser Met 
145                 150                 155                 160 
Thr Gly Phe Pro Trp Asn Ser Val Phe Gly Leu Pro Leu Pro Gly Phe 
                165                 170                 175     
Leu His Leu Thr Cys Pro His Tyr Trp Arg Tyr Gly Glu Glu Gly Glu 
            180                 185                 190         
Thr Glu Glu Gln Phe Val Ala Arg Leu Ala His Glu Leu Glu Glu Thr 
        195                 200                 205             
Ile Gln Lys Glu Gly Ala Asp Thr Ile Ala Gly Phe Phe Ala Glu Pro 
    210                 215                 220                 
Val Met Gly Ala Gly Gly Val Ile Pro Pro Ala Lys Gly Tyr Phe Gln 
225                 230                 235                 240 
Ala Ile Leu Pro Ile Leu Arg Lys Tyr Asp Ile Pro Val Ile Ser Asp 
                245                 250                 255     
Glu Val Ile Thr Gly Phe Gly Arg Thr Gly Asn Thr Trp Gly Cys Val 
            260                 265                 270         
Thr Tyr Asp Phe Thr Pro Asp Ala Ile Ile Ser Ala Lys Gly Leu Thr 
        275                 280                 285             
Ala Gly Tyr Phe Ala Val Gly Ala Val Ile Leu Gly Pro Glu Leu Ser 
    290                 295                 300                 
Lys Arg Leu Gln Thr Ala Ile Glu Leu Arg Glu Trp Phe Pro His Ala 
305                 310                 315                 320 
Phe Thr Thr Gly Gly His Pro Val Gly Cys Ala Ile Ala Leu Lys Ala 
                325                 330                 335     
Ile Asp Val Val Met Asn Glu Gly Leu Ala Glu Asn Val Arg Arg Leu 
            340                 345                 350         
Ala Pro Arg Phe Glu Glu Arg Leu Lys His Ile Ala Glu Arg Pro Asn 
        355                 360                 365             
Ile Gly Glu Tyr Arg Gly Ile Gly Phe Met Trp Ala Leu Glu Val Val 
    370                 375                 380                 
Lys Asp Lys Ala Ser Lys Ala Pro Phe Pro Gly Asn Leu Ser Val Ser 
385                 390                 395                 400 
Glu Arg Ile Ala Asn Thr Cys Thr Asp Leu Gly Leu Ile Val Arg Ala 
                405                 410                 415     
Leu Gly Gln Ser Val Ala Leu Ala Pro Pro Phe Ile Leu Thr Glu Ala 
            420                 425                 430         
Gln Met Asp Glu Met Phe Asp Lys Leu Glu Lys Ala Leu Asp Lys Val 
        435                 440                 445             
Phe Ala Glu Val Ala                                             
    450                                                         

 
<210> 171
<211> 1359
<212> DNA
<213> Artificial Sequence
 
<220>
<223> variant of transaminase from Vibrio fluvialis Js17
 
<400> 171
atgaacaaac cgcagagctg ggaaacgcgt gcagaaacct atagcctgat gggtcatacc 60
gatatgccga gcctgcatca gcgtggcacc atggtggtga cccatggcga aggcccgtat 120
atttttgatg tgcatggccg tcgttatctg gatgcgtgca gcggcgctgc gaacatggtg 180
gcgggctttg atcatccagg cctgattgat gcggcgaaaa cgcagtatga acgttttccg 240
ggctatcacg cggttaatgg ccgtatgagc gatcagaccg tgatgctgtc tgaaaaactg 300
gtggaagtga gcccgtttga tagcggccgt gtgttttata ccaacagcgg cagcgaagcg 360
aacgatacca tggtgaaaat gctgtggttt ctgcatgcgg cggaaggcaa accgcagaaa 420
cgtaaaattc tgacccattg gaacgcgtat catggcgcga ccgcggtgag cgcgagcatg 480
accggctttc cgtggaacag cgtgtttggc ctgccgctgc cgggctttct gcatctgacc 540
tgcccgcatt attggcgtta tggcgaagaa ggcgaaaccg aagaacagtt tgtcgcgcgt 600
ctggcccatg aactggaaga aaccattcag aaggaaggcg cggataccat tgcgggcttt 660
tttgcggaac cggtgatggg tgcgggcggt gttattccgc cggcaaaagg ctattttcag 720
gcgattctgc cgatcctgcg caaatatgat attccggtga tctccgatga agtgattacc 780
ggcttcggcc gtaccggtaa cacctggggc tgcgtaacct atgattttac cccggatgcg 840
attattagcg cgaaaggcct aaccgcgggt tattttgcgg taggcgcggt gattctgggt 900
ccggaactga gcaaacgtct ggaaaccgcg attgaactgc gtgaatggtt tccgcatgct 960
tttaccacag gtggccatcc ggtgggttgt gcgattgcgc tgaaagcgat tgatgtggtg 1020
atgaacgaag gcctggccga aaacgtgcgt cgtctggccc cgcgttttga agaacgtctg 1080
aaacatattg cggaacgtcc gaacattggc gaatatcgtg gcattggctt tatgtgggcg 1140
ctggaagtcg tgaaagataa agcgagcaaa gccccgtttc ccggcaacct gagcgtgagc 1200
gaacgtattg cgaacacctg caccgatctg ggcctgattg tgcgtgcgct gggccagagc 1260
gtggcgctgg cgccgccgtt tattctgacc gaagcgcaga tggatgaaat gttcgataaa 1320
ctggaaaaag cgctggataa agtgttcgcg gaagtggcg                        1359

 
<210> 172
<211> 453
<212> PRT
<213> Artificial Sequence
 
<220>
<223> variant of transaminase from Vibrio fluvialis Js17
 
<400> 172
Met Asn Lys Pro Gln Ser Trp Glu Thr Arg Ala Glu Thr Tyr Ser Leu 
1               5                   10                  15      
Met Gly His Thr Asp Met Pro Ser Leu His Gln Arg Gly Thr Met Val 
            20                  25                  30          
Val Thr His Gly Glu Gly Pro Tyr Ile Phe Asp Val His Gly Arg Arg 
        35                  40                  45              
Tyr Leu Asp Ala Cys Ser Gly Ala Ala Asn Met Val Ala Gly Phe Asp 
    50                  55                  60                  
His Pro Gly Leu Ile Asp Ala Ala Lys Thr Gln Tyr Glu Arg Phe Pro 
65                  70                  75                  80  
Gly Tyr His Ala Val Asn Gly Arg Met Ser Asp Gln Thr Val Met Leu 
                85                  90                  95      
Ser Glu Lys Leu Val Glu Val Ser Pro Phe Asp Ser Gly Arg Val Phe 
            100                 105                 110         
Tyr Thr Asn Ser Gly Ser Glu Ala Asn Asp Thr Met Val Lys Met Leu 
        115                 120                 125             
Trp Phe Leu His Ala Ala Glu Gly Lys Pro Gln Lys Arg Lys Ile Leu 
    130                 135                 140                 
Thr His Trp Asn Ala Tyr His Gly Ala Thr Ala Val Ser Ala Ser Met 
145                 150                 155                 160 
Thr Gly Phe Pro Trp Asn Ser Val Phe Gly Leu Pro Leu Pro Gly Phe 
                165                 170                 175     
Leu His Leu Thr Cys Pro His Tyr Trp Arg Tyr Gly Glu Glu Gly Glu 
            180                 185                 190         
Thr Glu Glu Gln Phe Val Ala Arg Leu Ala His Glu Leu Glu Glu Thr 
        195                 200                 205             
Ile Gln Lys Glu Gly Ala Asp Thr Ile Ala Gly Phe Phe Ala Glu Pro 
    210                 215                 220                 
Val Met Gly Ala Gly Gly Val Ile Pro Pro Ala Lys Gly Tyr Phe Gln 
225                 230                 235                 240 
Ala Ile Leu Pro Ile Leu Arg Lys Tyr Asp Ile Pro Val Ile Ser Asp 
                245                 250                 255     
Glu Val Ile Thr Gly Phe Gly Arg Thr Gly Asn Thr Trp Gly Cys Val 
            260                 265                 270         
Thr Tyr Asp Phe Thr Pro Asp Ala Ile Ile Ser Ala Lys Gly Leu Thr 
        275                 280                 285             
Ala Gly Tyr Phe Ala Val Gly Ala Val Ile Leu Gly Pro Glu Leu Ser 
    290                 295                 300                 
Lys Arg Leu Glu Thr Ala Ile Glu Leu Arg Glu Trp Phe Pro His Ala 
305                 310                 315                 320 
Phe Thr Thr Gly Gly His Pro Val Gly Cys Ala Ile Ala Leu Lys Ala 
                325                 330                 335     
Ile Asp Val Val Met Asn Glu Gly Leu Ala Glu Asn Val Arg Arg Leu 
            340                 345                 350         
Ala Pro Arg Phe Glu Glu Arg Leu Lys His Ile Ala Glu Arg Pro Asn 
        355                 360                 365             
Ile Gly Glu Tyr Arg Gly Ile Gly Phe Met Trp Ala Leu Glu Val Val 
    370                 375                 380                 
Lys Asp Lys Ala Ser Lys Ala Pro Phe Pro Gly Asn Leu Ser Val Ser 
385                 390                 395                 400 
Glu Arg Ile Ala Asn Thr Cys Thr Asp Leu Gly Leu Ile Val Arg Ala 
                405                 410                 415     
Leu Gly Gln Ser Val Ala Leu Ala Pro Pro Phe Ile Leu Thr Glu Ala 
            420                 425                 430         
Gln Met Asp Glu Met Phe Asp Lys Leu Glu Lys Ala Leu Asp Lys Val 
        435                 440                 445             
Phe Ala Glu Val Ala                                             
    450                                                         

