                         SEQUENCE LISTING

<110>  Singapore Health Services Pte Ltd
       ALBANI, Salvatore
       LEONG, Jing Yao
 
<120>  Methods and kits for evaluating clinical outcomes of autoimmune 
       disease

<130>  2018.p01130

<150>  SG 10201704905R
<151>  2017-06-14

<160>  82    

<170>  PatentIn version 3.5

<210>  1
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD3 HCDR1

<400>  1

Gly Tyr Gly Met His 
1               5   


<210>  2
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD3 HCDR2

<400>  2

Val Ile Trp Tyr Asp Gly Ser Lys Lys Tyr Tyr Val Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  3
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD3 HCDR3

<400>  3

Gln Met Gly Tyr Trp His Phe Asp Leu 
1               5                   


<210>  4
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD3 LCDR1

<400>  4

Arg Ala Ser Gln Ser Val Ser Ser Tyr Leu Ala 
1               5                   10      


<210>  5
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD3 LCDR2

<400>  5

Asp Ala Ser Asn Arg Ala Thr 
1               5           


<210>  6
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD3 LCDR3

<400>  6

Gln Gln Arg Ser Asn Trp Pro Pro Leu Thr 
1               5                   10  


<210>  7
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD4 HCDR1

<400>  7

Leu Ala Ser Glu Asp Ile Tyr Ser Asp Leu Ala 
1               5                   10      


<210>  8
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD4 HCDR2

<400>  8

Asn Thr Asp Thr Leu Gln Asn 
1               5           


<210>  9
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD4 HCDR3

<400>  9

Gln Gln Tyr Asn Asn Tyr Pro Trp Thr 
1               5                   


<210>  10
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD4 LCDR1

<400>  10

Asn Tyr Gly Met Ala 
1               5   


<210>  11
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD4 LCDR2

<400>  11

Thr Ile Ser His Asp Gly Ser Asp Thr Tyr Phe Arg Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  12
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD4 LCDR3

<400>  12

Gln Gly Thr Ile Ala Gly Ile Arg His 
1               5                   


<210>  13
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD45RA HCDR1

<400>  13

Asn Tyr Ile Ile His 
1               5   


<210>  14
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD45RA HCDR2

<400>  14

Tyr Phe Asn Pro Tyr Asn His Gly Thr Lys Tyr Asn Glu Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  15
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD45RA HCDR3

<400>  15

Ser Gly Pro Tyr Ala Trp Phe Asp Thr 
1               5                   


<210>  16
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD45RA LCDR1

<400>  16

Arg Ala Ser Gln Asn Ile Gly Thr Ser Ile Gln 
1               5                   10      


<210>  17
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD45RA LCDR2

<400>  17

Ser Ser Ser Glu Ser Ile Ser 
1               5           


<210>  18
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD45RA LCDR3

<400>  18

Gln Gln Ser Asn Thr Trp Pro Phe Thr 
1               5                   


<210>  19
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TNF-alpha HCDR1

<400>  19

Asn Tyr Trp Met Asn 
1               5   


<210>  20
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TNF-alpha HCDR2

<400>  20

Glu Val Arg Leu Gln Ser Asp Asn Phe Thr Thr Ser His Tyr Ala Glu 
1               5                   10                  15      


Ser Val Lys Gly 
            20  


<210>  21
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TNF-alpha HCDR3

<400>  21

Pro Phe Ala Tyr 
1               


<210>  22
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TNF-alpha LCDR1

<400>  22

Ser Ala Ser Ser Ser Val Ser Phe Met Tyr 
1               5                   10  


<210>  23
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TNF-alpha LCDR2

<400>  23

Asp Ala Ser Ile Leu Ala Ser 
1               5           


<210>  24
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TNF-alpha LCDR3

<400>  24

Gln Gln Trp Ser Asp Tyr Ser Pro Arg Thr 
1               5                   10  


<210>  25
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CXCR5 HCDR1

<400>  25

Gly Phe Ser Leu Ile Asp Tyr Gly Val Asn 
1               5                   10  


<210>  26
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CXCR5 HCDR2

<400>  26

Val Ile Trp Gly Asp Gly Thr Thr Tyr 
1               5                   


<210>  27
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CXCR5 HCDR3

<400>  27

Ile Val Tyr 
1           


<210>  28
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CXCR5 LCDR1

<400>  28

Arg Ser Ser Lys Ser Leu Leu His Ser Ser Gly Lys Thr Tyr Leu Tyr 
1               5                   10                  15      


<210>  29
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CXCR5 LCDR2

<400>  29

Arg Leu Ser Asn Leu Ala Ser 
1               5           


<210>  30
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CXCR5 LCDR3

<400>  30

Met Gln His Leu Glu Tyr Pro Tyr Thr 
1               5                   


<210>  31
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL-6 HCDR1

<400>  31

Gly Glu Asn Phe Asn Asp Tyr Phe Met Asn 
1               5                   10  


<210>  32
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL-6 HCDR2

<400>  32

Gln Met Arg Asn Lys Asn Tyr Gln Tyr Gly Thr Tyr Tyr Ala Glu Ser 
1               5                   10                  15      


Leu Glu Gly 
            


<210>  33
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL-6 HCDR1

<400>  33

Glu Ser Tyr Tyr Gly Phe Thr Ser Tyr 
1               5                   


<210>  34
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL-6 LCDR1

<400>  34

Gln Ala Ser Gln Asp Ile Gly Ile Ser Leu Ser 
1               5                   10      


<210>  35
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL-6 LCDR2

<400>  35

Asn Ala Asn Asn Leu Ala Asp 
1               5           


<210>  36
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL-6 LCDR3

<400>  36

Gln His Asn Ser Ala Pro Tyr Thr 
1               5               


<210>  37
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IFG-g HCDR1

<400>  37

Ser Tyr Ala Met Ser 
1               5   


<210>  38
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IFG-g HCDR2

<400>  38

Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  39
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IFG-g HCDR3

<400>  39

Asp Gly Ser Ser Gly Trp Tyr Val Pro His Trp Phe Asp Pro 
1               5                   10                  


<210>  40
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IFG-g LCDR1

<400>  40

Thr Arg Ser Ser Gly Ser Ile Ala Ser Asn Tyr Val Gln 
1               5                   10              


<210>  41
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IFG-g LCDR2

<400>  41

Glu Asp Asn Gln Arg Pro Ser 
1               5           


<210>  42
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IFG-g LCDR3

<400>  42

Gln Ser Tyr Asp Gly Ser Asn Arg Trp Met 
1               5                   10  


<210>  43
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL-21 HCDR1

<400>  43

Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr Trp Met His 
1               5                   10              


<210>  44
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL-21 HCDR2

<400>  44

Leu Ile Asp Thr Ser Asp Val Tyr Thr Ile Tyr Asn Gln Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  45
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL-21 HCDR3

<400>  45

Ala Arg Tyr Gly Pro Leu Ala Met Asp Tyr 
1               5                   10  


<210>  46
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL-21 LCDR1

<400>  46

Arg Ala Ser Gln Asp Ile Ser Asn Tyr Leu Asn 
1               5                   10      


<210>  47
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL-21 LCDR2

<400>  47

Tyr Tyr Thr Ser Arg Leu His Ser 
1               5               


<210>  48
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL-21 LCDR3

<400>  48

Gln Gln Phe His Thr Leu Arg Thr 
1               5               


<210>  49
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CXCR3 HCDR1

<400>  49

Asn Tyr Met Ala Ser 
1               5   


<210>  50
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CXCR3 HCDR2

<400>  50

Thr Ile Ser Ser Gly Gly Gly Tyr Thr Tyr Tyr Pro Asp Ser Leu Lys 
1               5                   10                  15      


Gly 
    


<210>  51
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CXCR3 HCDR3

<400>  51

His Gly Ala Pro Met Thr Thr Val Ile Thr Tyr Ala Pro Tyr Tyr Phe 
1               5                   10                  15      


<210>  52
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CXCR3 LCDR1

<400>  52

Arg Ala Ser Ser Ser Val Lys Tyr Met Tyr 
1               5                   10  


<210>  53
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CXCR3 LCDR2

<400>  53

Tyr Thr Ser Asn Leu Ala Pro 
1               5           


<210>  54
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CXCR3 LCDR3

<400>  54

Gln Gln Phe Thr Thr Ser Pro Tyr Thr 
1               5                   


<210>  55
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CCR6 HCDR1

<400>  55

Phe Ile Phe Thr Thr Tyr Tyr Met Ser Trp Val Arg 
1               5                   10          


<210>  56
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CCR6 HCDR2

<400>  56

Val Ser Asn Ile Ala Ala Gly Gly Ala Thr Asp Tyr Ala Asp Ser 
1               5                   10                  15  


<210>  57
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CCR6 HCDR3

<400>  57

Cys Ala Arg Gly Pro Trp Gly Arg Tyr His Pro Met Gly Phe Asp Tyr 
1               5                   10                  15      


Trp Gly Gln 
            


<210>  58
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CCR6 LCDR1

<400>  58

Arg Ala Ser Gln Ser Val Ser Ser Ser Tyr Leu Ala 
1               5                   10          


<210>  59
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CCR6 LCDR2

<400>  59

Gly Ala Ser Ser Arg Ala Thr 
1               5           


<210>  60
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CCR6 LCDR3

<400>  60

Cys Gln Gln Ala Tyr Tyr Ser Pro Val Thr Phe Gly Gln 
1               5                   10              


<210>  61
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD152 HCDR1

<400>  61

Phe Ser Leu Ser Asp Tyr Gly Val His 
1               5                   


<210>  62
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD152 HCDR2

<400>  62

Val Ile Trp Ala Gly Gly Gly Thr Asn Tyr Asn Ser Ala Leu Met Ser 
1               5                   10                  15      


<210>  63
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD152 HCDR3

<400>  63

Gly Tyr Ser Ser Thr Ser Phe 
1               5           


<210>  64
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD152 LCDR1

<400>  64

Arg Ala Ser Glu Ser Val Glu Tyr Tyr Val Thr Ser Leu 
1               5                   10              


<210>  65
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD152 LCDR2

<400>  65

Ala Ala Ser Asn Val Glu Ser 
1               5           


<210>  66
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD152 LCDR3

<400>  66

Gln Gln Ser Arg Lys Val Pro Tyr 
1               5               


<210>  67
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD1 HCDR1

<400>  67

Gly Tyr Thr Phe Thr Thr Tyr Tyr Leu Tyr 
1               5                   10  


<210>  68
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD1 HCDR2

<400>  68

Gly Ile Asn Pro Ser Asn Gly Gly Thr Asn Phe Asn Glu Lys Phe 
1               5                   10                  15  


<210>  69
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD1 HCDR3

<400>  69

Arg Asp Tyr Arg Tyr Asp Arg Gly 
1               5               


<210>  70
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD1 LCDR1

<400>  70

Arg Ala Ser Lys Ser Val Ser Thr Ser Gly Phe Asn Tyr Ile His 
1               5                   10                  15  


<210>  71
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD1 LCDR2

<400>  71

Leu Ala Ser Asn Leu Glu Ser 
1               5           


<210>  72
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD1 LCDR3

<400>  72

Gln His Ser Arg Glu Leu Pro Leu Thr 
1               5                   


<210>  73
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  FYN forward primer

<400>  73
gccgcctagt agttccctgt                                                   20


<210>  74
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  FYN reverse primer

<400>  74
cttcatgatc tgcgcttcct                                                   20


<210>  75
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TRAF1 forward primer

<400>  75
cactgccaag tatggttaca agt                                               23


<210>  76
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TRAF1 reverse primer

<400>  76
ggttgttctg gtcaagtagc at                                                22


<210>  77
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TNFRSF9 forward primer

<400>  77
tgtaaaacga cggccagt                                                     18


<210>  78
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TNFRSF9 reverse primer

<400>  78
caggaaacag ctatgacc                                                     18


<210>  79
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IKBKE forward primer

<400>  79
cagggcttgg ctacaacgag                                                   20


<210>  80
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IKBKE reverse primer

<400>  80
gatgtccagg aggtcagatg c                                                 21


<210>  81
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CASP1 forward primer

<400>  81
acaaggcacg ggacctatg                                                    19


<210>  82
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CASP1 reverse primer

<400>  82
tcccagtcag tcctggaaat g                                                 21


