                         SEQUENCE LISTING

<110>  YEDA RESEARCH AND DEVELOPMENT CO. LTD.
       MIRELMAN, David
       AHARONI, Rina
       RABINKOV, Aharon
       ARNON, Ruth
 
<120>  TREATMENT OF ADVANCED OR PROGRESSIVE MULTIPLE SCLEROSIS

<130>  74017

<150>  US 62/518,664
<151>  2017-06-13

<160>  3     

<170>  PatentIn version 3.5

<210>  1
<211>  2140
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  recombinant GOT nucleic acid sequence

<400>  1
gcgttccttc tcccctgtgc cttcgtcgtc agaagctggc gattggttaa tcgcgttgcc       60

aagctttgga cgcggctcga ccattggagg ccgcgggccc gcccccgccg gctaggtgaa      120

ggtgagtgtc tcctccagtc gcaacggcca gacctgacct gccagctccg ggcgtggggt      180

gaaatctctt gattcctagt ctctcgatat ggcacctccg tcagtctttg ccgaggttcc      240

gcaggcccag cctgtcctgg tcttcaagct cactgccgac ttcagggagg atccggaccc      300

ccgcaaggtc aacctgggag tgggagcata tcgcacggat gactgccatc cctgggtttt      360

gccagtagtg aagaaagtgg agcagaagat tgctaatgac aatagcctaa atcacgagta      420

tctgccaatc ctgggcctgg ctgagttccg gagctgtgct tctcgtcttg cccttgggga      480

tgacagccca gcactcaagg agaagcgggt aggaggtgtg caatctttgg ggggaacagg      540

tgcacttcga attggagctg atttcttagc gcgttggtac aatggaacaa acaacaagaa      600

cacacctgtc tatgtgtcct caccaacctg ggagaatcac aatgctgtgt tttccgctgc      660

tggttttaaa gacattcggt cctatcgcta ctgggatgca gagaagagag gattggacct      720

ccagggcttc ctgaatgatc tggagaatgc tcctgagttc tccattgttg tcctccacgc      780

ctgtgcacac aacccaactg ggattgaccc aactccggag cagtggaagc agattgcttc      840

tgtcatgaag caccggtttc tgttcccctt ctttgactca gcctatcagg gcttcgcatc      900

tggaaacctg gagagagatg cctgggccat tcgctatttt gtgtctgaag gcttcgagtt      960

cttctgtgcc cagtccttct ccaagaactt cgggctctac aatgagagag tcgggaatct     1020

gactgtggtt ggaaaagaac ctgagagcat cctgcaagtc ctttcccaga tggagaagat     1080

cgtgcggatt acttggtcca atccccccgc ccagggagca cgaattgtgg ccagcaccct     1140

ctctaaccct gagctctttg aggaatggac aggtaatgtg aagacaatgg ctgaccggat     1200

tctgaccatg agatctgaac tcagggcacg actagaagcc ctcaaaaccc ctgggacctg     1260

gaaccacatc actgatcaaa ttggcatgtt cagcttcact gggttgaacc ccaagcaggt     1320

tgagtatctg gtcaatgaaa agcacatcta cctgctgcca agtggtcgaa tcaacgtgag     1380

tggcttaacc accaaaaatc tagattacgt ggccacctcc atccatgaag cagtcaccaa     1440

aatccagtga agaaacacca cccgtccagt accaccaaag tagttctctg tcatgtgtgt     1500

tccctgcctg cacaaaccta catgtacata ccatggatta gagacacttg caggactgaa     1560

aggctgctct ggtgaggcag cctctgttta aaccggcccc acatgaagag aacatccctt     1620

gagacgaatt tggagactgg gattagagcc tttggaggtc aaagcaaatt aagattttta     1680

tttaagaata aaagagtact ttgatcatga gacataggta tcttgtccct ctcactaaaa     1740

aggagtgttg tgtgtggcgg ccacgtgctt ctatgtggtg tttgactctg tacaaattct     1800

agtcccaaag atcaagttgt ctgaaggagc caaagtgtga atgtgggtgt cggctgcggc     1860

attaaattca tcatctcaac ccagagtgtc tggtctccct gctctttctg catggttgtg     1920

tccctagtcc taagctttgg ttctttaggg tgactgtggt aagaaggata tttaatcatg     1980

acatgcacgg acacgtacat atttaactga aacaagtttt accaaacagt atttactcgt     2040

gatgtgcgta gtgcattctg atatttttga gccattctat tgtgttctac ttcacctaaa     2100

aaaataaaat aaaaatgttg atcaagaaaa aaaaaaaaaa                           2140


<210>  2
<211>  1242
<212>  DNA
<213>  Homo sapiens

<400>  2
atggcacctc cgtcagtctt tgccgaggtt ccgcaggccc agcctgtcct ggtcttcaag       60

ctcactgccg acttcaggga ggatccggac ccccgcaagg tcaacctggg agtgggagca      120

tatcgcacgg atgactgcca tccctgggtt ttgccagtag tgaagaaagt ggagcagaag      180

attgctaatg acaatagcct aaatcacgag tatctgccaa tcctgggcct ggctgagttc      240

cggagctgtg cttctcgtct tgcccttggg gatgacagcc cagcactcaa ggagaagcgg      300

gtaggaggtg tgcaatcttt ggggggaaca ggtgcacttc gaattggagc tgatttctta      360

gcgcgttggt acaatggaac aaacaacaag aacacacctg tctatgtgtc ctcaccaacc      420

tgggagaatc acaatgctgt gttttccgct gctggtttta aagacattcg gtcctatcgc      480

tactgggatg cagagaagag aggattggac ctccagggct tcctgaatga tctggagaat      540

gctcctgagt tctccattgt tgtcctccac gcctgtgcac acaacccaac tgggattgac      600

ccaactccgg agcagtggaa gcagattgct tctgtcatga agcaccggtt tctgttcccc      660

ttctttgact cagcctatca gggcttcgca tctggaaacc tggagagaga tgcctgggcc      720

attcgctatt ttgtgtctga aggcttcgag ttcttctgtg cccagtcctt ctccaagaac      780

ttcgggctct acaatgagag agtcgggaat ctgactgtgg ttggaaaaga acctgagagc      840

atcctgcaag tcctttccca gatggagaag atcgtgcgga ttacttggtc caatcccccc      900

gcccagggag cacgaattgt ggccagcacc ctctctaacc ctgagctctt tgaggaatgg      960

acaggtaatg tgaagacaat ggctgaccgg attctgacca tgagatctga actcagggca     1020

cgactagaag ccctcaaaac ccctgggacc tggaaccaca tcactgatca aattggcatg     1080

ttcagcttca ctgggttgaa ccccaagcag gttgagtatc tggtcaatga aaagcacatc     1140

tacctgctgc caagtggtcg aatcaacgtg agtggcttaa ccaccaaaaa tctagattac     1200

gtggccacct ccatccatga agcagtcacc aaaatccagt ga                        1242


<210>  3
<211>  412
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recombinant GOT1 amino acid sequence

<400>  3

Ala Pro Pro Ser Val Phe Ala Glu Val Pro Gln Ala Gln Pro Val Leu 
1               5                   10                  15      


Val Phe Lys Leu Thr Ala Asp Phe Arg Glu Asp Pro Asp Pro Arg Lys 
            20                  25                  30          


Val Asn Leu Gly Val Gly Ala Tyr Arg Thr Asp Asp Cys His Pro Trp 
        35                  40                  45              


Val Leu Pro Val Val Lys Lys Val Glu Gln Lys Ile Ala Asn Asp Asn 
    50                  55                  60                  


Ser Leu Asn His Glu Tyr Leu Pro Ile Leu Gly Leu Ala Glu Phe Arg 
65                  70                  75                  80  


Ser Cys Ala Ser Arg Leu Ala Leu Gly Asp Asp Ser Pro Ala Leu Lys 
                85                  90                  95      


Glu Lys Arg Val Gly Gly Val Gln Ser Leu Gly Gly Thr Gly Ala Leu 
            100                 105                 110         


Arg Ile Gly Ala Asp Phe Leu Ala Arg Trp Tyr Asn Gly Thr Asn Asn 
        115                 120                 125             


Lys Asn Thr Pro Val Tyr Val Ser Ser Pro Thr Trp Glu Asn His Asn 
    130                 135                 140                 


Ala Val Phe Ser Ala Ala Gly Phe Lys Asp Ile Arg Ser Tyr Arg Tyr 
145                 150                 155                 160 


Trp Asp Ala Glu Lys Arg Gly Leu Asp Leu Gln Gly Phe Leu Asn Asp 
                165                 170                 175     


Leu Glu Asn Ala Pro Glu Phe Ser Ile Val Val Leu His Ala Cys Ala 
            180                 185                 190         


His Asn Pro Thr Gly Ile Asp Pro Thr Pro Glu Gln Trp Lys Gln Ile 
        195                 200                 205             


Ala Ser Val Met Lys His Arg Phe Leu Phe Pro Phe Phe Asp Ser Ala 
    210                 215                 220                 


Tyr Gln Gly Phe Ala Ser Gly Asn Leu Glu Arg Asp Ala Trp Ala Ile 
225                 230                 235                 240 


Arg Tyr Phe Val Ser Glu Gly Phe Glu Phe Phe Cys Ala Gln Ser Phe 
                245                 250                 255     


Ser Lys Asn Phe Gly Leu Tyr Asn Glu Arg Val Gly Asn Leu Thr Val 
            260                 265                 270         


Val Gly Lys Glu Pro Glu Ser Ile Leu Gln Val Leu Ser Gln Met Glu 
        275                 280                 285             


Lys Ile Val Arg Ile Thr Trp Ser Asn Pro Pro Ala Gln Gly Ala Arg 
    290                 295                 300                 


Ile Val Ala Ser Thr Leu Ser Asn Pro Glu Leu Phe Glu Glu Trp Thr 
305                 310                 315                 320 


Gly Asn Val Lys Thr Met Ala Asp Arg Ile Leu Thr Met Arg Ser Glu 
                325                 330                 335     


Leu Arg Ala Arg Leu Glu Ala Leu Lys Thr Pro Gly Thr Trp Asn His 
            340                 345                 350         


Ile Thr Asp Gln Ile Gly Met Phe Ser Phe Thr Gly Leu Asn Pro Lys 
        355                 360                 365             


Gln Val Glu Tyr Leu Val Asn Glu Lys His Ile Tyr Leu Leu Pro Ser 
    370                 375                 380                 


Gly Arg Ile Asn Val Ser Gly Leu Thr Thr Lys Asn Leu Asp Tyr Val 
385                 390                 395                 400 


Ala Thr Ser Ile His Glu Ala Val Thr Lys Ile Gln 
                405                 410         


