                         SEQUENCE LISTING

<110>  Novartis AG
 
<120>  COMBINATION THERAPY FOR THE TREATMENT OF CANCER

<130>  PAT057750-WO-PCT

<150>  US 62/520,859
<151>  2017-06-16

<160>  278   

<170>  PatentIn version 3.5

<210>  1
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NOV0281 HCDR1 (Kabat)

<400>  1

Asp Tyr Ala Ile Ser 
1               5   


<210>  2
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NOV0281 HCDR2 (Kabat)

<400>  2

Gly Ile Ile Pro Ile Ser Gly Thr Ala Asn Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  3
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NOV0281 HCDR3 (Kabat)

<400>  3

Asp His Ser Ser Ser Ser Tyr Asp Tyr Gln Tyr Gly Leu Ala Val 
1               5                   10                  15  


<210>  4
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NOV0281 VH

<400>  4

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Asp Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Ile Ser Gly Thr Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp His Ser Ser Ser Ser Tyr Asp Tyr Gln Tyr Gly Leu Ala 
            100                 105                 110         


Val Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  5
<211>  372
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  NOV0281 DNA VH

<400>  5
caggtgcagc tggtgcagtc aggcgccgaa gtgaagaaac ccggctctag cgtgaaagtc       60

agctgtaaag ctagtggcgg cacctttagc gactacgcta ttagctgggt cagacaggcc      120

ccaggtcagg gcctggagtg gatgggcgga attatcccta ttagcggcac cgctaactac      180

gctcagaaat ttcagggtag agtgactatc accgccgacg agtctactag caccgcctat      240

atggaactgt ctagcctgag atcagaggac accgccgtct actactgcgc tagagatcac      300

tctagctcta gctacgacta tcagtacggc ctggccgtgt ggggtcaggg caccctggtc      360

accgtgtcta gc                                                          372


<210>  6
<211>  454
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NOV0281 Heavy Chain

<400>  6

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Asp Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Ile Ser Gly Thr Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp His Ser Ser Ser Ser Tyr Asp Tyr Gln Tyr Gly Leu Ala 
            100                 105                 110         


Val Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys 
        115                 120                 125             


Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly 
    130                 135                 140                 


Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro 
145                 150                 155                 160 


Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr 
                165                 170                 175     


Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val 
            180                 185                 190         


Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn 
        195                 200                 205             


Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro 
    210                 215                 220                 


Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
225                 230                 235                 240 


Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
                245                 250                 255     


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
            260                 265                 270         


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
        275                 280                 285             


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
    290                 295                 300                 


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
305                 310                 315                 320 


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 
                325                 330                 335     


Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
            340                 345                 350         


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn 
        355                 360                 365             


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
    370                 375                 380                 


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
385                 390                 395                 400 


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
                405                 410                 415     


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
            420                 425                 430         


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
        435                 440                 445             


Ser Leu Ser Pro Gly Lys 
    450                 


<210>  7
<211>  1362
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  NOV0281 DNA Heavy Chain

<400>  7
caggtgcagc tggtgcagtc aggcgccgaa gtgaagaaac ccggctctag cgtgaaagtc       60

agctgtaaag ctagtggcgg cacctttagc gactacgcta ttagctgggt cagacaggcc      120

ccaggtcagg gcctggagtg gatgggcgga attatcccta ttagcggcac cgctaactac      180

gctcagaaat ttcagggtag agtgactatc accgccgacg agtctactag caccgcctat      240

atggaactgt ctagcctgag atcagaggac accgccgtct actactgcgc tagagatcac      300

tctagctcta gctacgacta tcagtacggc ctggccgtgt ggggtcaggg caccctggtc      360

accgtgtcta gcgctagcac taagggccca agtgtgtttc ccctggcccc cagcagcaag      420

tctacttccg gcggaactgc tgccctgggt tgcctggtga aggactactt ccccgagccc      480

gtgacagtgt cctggaactc tggggctctg acttccggcg tgcacacctt ccccgccgtg      540

ctgcagagca gcggcctgta cagcctgagc agcgtggtga cagtgccctc cagctctctg      600

ggaacccaga cctatatctg caacgtgaac cacaagccca gcaacaccaa ggtggacaag      660

agagtggagc ccaagagctg cgacaagacc cacacctgcc ccccctgccc agctccagaa      720

ctgctgggag ggccttccgt gttcctgttc ccccccaagc ccaaggacac cctgatgatc      780

agcaggaccc ccgaggtgac ctgcgtggtg gtggacgtgt cccacgagga cccagaggtg      840

aagttcaact ggtacgtgga cggcgtggag gtgcacaacg ccaagaccaa gcccagagag      900

gagcagtaca acagcaccta cagggtggtg tccgtgctga ccgtgctgca ccaggactgg      960

ctgaacggca aagaatacaa gtgcaaagtc tccaacaagg ccctgccagc cccaatcgaa     1020

aagacaatca gcaaggccaa gggccagcca cgggagcccc aggtgtacac cctgcccccc     1080

agccgggagg agatgaccaa gaaccaggtg tccctgacct gtctggtgaa gggcttctac     1140

cccagcgata tcgccgtgga gtgggagagc aacggccagc ccgagaacaa ctacaagacc     1200

acccccccag tgctggacag cgacggcagc ttcttcctgt acagcaagct gaccgtggac     1260

aagtccaggt ggcagcaggg caacgtgttc agctgcagcg tgatgcacga ggccctgcac     1320

aaccactaca cccagaagtc cctgagcctg agccccggca ag                        1362


<210>  8
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NOV0281 LCDR1 (Kabat)

<400>  8

Ser Gly Asp Lys Leu Gly Asp Tyr Tyr Val His 
1               5                   10      


<210>  9
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NOV0281 LCDR2 (Kabat)

<400>  9

Gln Asp Ser Lys Arg Pro Ser 
1               5           


<210>  10
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NOV0281 LCDR3 (Kabat)

<400>  10

Gly Ala Thr Asp Leu Ser Pro Trp Ser Ile Val 
1               5                   10      


<210>  11
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NOV0281 VL

<400>  11

Asp Ile Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ser Pro Gly Glu 
1               5                   10                  15      


Thr Ala Ser Ile Thr Cys Ser Gly Asp Lys Leu Gly Asp Tyr Tyr Val 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr 
        35                  40                  45              


Gln Asp Ser Lys Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  


Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Gly Thr Gln Ala Glu 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Gly Ala Thr Asp Leu Ser Pro Trp Ser 
                85                  90                  95      


Ile Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105             


<210>  12
<211>  324
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  NOV0281 DNA VL

<400>  12
gatatcgagc tgactcagcc ccctagcgtc agcgtcagcc ctggcgagac agcctctatc       60

acctgtagcg gcgataagct gggcgactac tacgtgcact ggtatcagca gaagcccggt      120

caggcccccg tgctggtgat ctatcaggac tctaagcggc ctagcggaat ccccgagcgg      180

tttagcggct ctaatagcgg taacaccgct accctgacta ttagcggcac tcaggccgag      240

gacgaggccg actactactg cggcgctacc gacctgagcc cctggtctat cgtgttcggc      300

ggaggcacta agctgaccgt gctg                                             324


<210>  13
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NOV0281 Light Chain

<400>  13

Asp Ile Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ser Pro Gly Glu 
1               5                   10                  15      


Thr Ala Ser Ile Thr Cys Ser Gly Asp Lys Leu Gly Asp Tyr Tyr Val 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr 
        35                  40                  45              


Gln Asp Ser Lys Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  


Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Gly Thr Gln Ala Glu 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Gly Ala Thr Asp Leu Ser Pro Trp Ser 
                85                  90                  95      


Ile Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln Pro Lys 
            100                 105                 110         


Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu Leu Gln 
        115                 120                 125             


Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr Pro Gly 
    130                 135                 140                 


Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys Ala Gly 
145                 150                 155                 160 


Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr Ala Ala 
                165                 170                 175     


Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His Arg Ser 
            180                 185                 190         


Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys Thr Val 
        195                 200                 205             


Ala Pro Thr Glu Cys Ser 
    210                 


<210>  14
<211>  642
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  NOV0281 DNA Light Chain

<400>  14
gatatcgagc tgactcagcc ccctagcgtc agcgtcagcc ctggcgagac agcctctatc       60

acctgtagcg gcgataagct gggcgactac tacgtgcact ggtatcagca gaagcccggt      120

caggcccccg tgctggtgat ctatcaggac tctaagcggc ctagcggaat ccccgagcgg      180

tttagcggct ctaatagcgg taacaccgct accctgacta ttagcggcac tcaggccgag      240

gacgaggccg actactactg cggcgctacc gacctgagcc cctggtctat cgtgttcggc      300

ggaggcacta agctgaccgt gctgggtcag cctaaggctg cccccagcgt gaccctgttc      360

ccccccagca gcgaggagct gcaggccaac aaggccaccc tggtgtgcct gatcagcgac      420

ttctacccag gcgccgtgac cgtggcctgg aaggccgaca gcagccccgt gaaggccggc      480

gtggagacca ccacccccag caagcagagc aacaacaagt acgccgccag cagctacctg      540

agcctgaccc ccgagcagtg gaagagccac aggtcctaca gctgccaggt gacccacgag      600

ggcagcaccg tggaaaagac cgtggcccca accgagtgca gc                         642


<210>  15
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NOV0308 HCDR1 (Kabat)

<400>  15

Ser Tyr Ala Ile Ser 
1               5   


<210>  16
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NOV0308 HCDR2 (Kabat)

<400>  16

Gly Ile Ile Pro Val Leu Gly Thr Ala Asn Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  17
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NOV0308 HCDR3 (Kabat)

<400>  17

Val Pro Thr Asp Tyr Phe Asp Tyr 
1               5               


<210>  18
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NOV0308 VH

<400>  18

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Val Leu Gly Thr Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Val Pro Thr Asp Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  19
<211>  351
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  NOV0308 DNA VH

<400>  19
caggtgcagc tggtgcagtc aggcgccgaa gtgaagaaac ccggctctag cgtgaaagtc       60

agctgtaaag ctagtggcgg caccttctct agctacgcta ttagctgggt cagacaggcc      120

ccaggtcagg gcctggagtg gatgggcgga attatccccg tgctgggcac cgctaactac      180

gctcagaaat ttcagggtag agtgactatc accgccgacg agtctactag caccgcctat      240

atggaactgt ctagcctgag atcagaggac accgccgtct actactgcgc tagagtgcct      300

accgactact tcgactactg gggtcagggc accctggtca ccgtgtctag c               351


<210>  20
<211>  447
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NOV0308 Heavy Chain

<400>  20

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Val Leu Gly Thr Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Val Pro Thr Asp Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
        115                 120                 125             


Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys 
    130                 135                 140                 


Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
145                 150                 155                 160 


Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
                165                 170                 175     


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
            180                 185                 190         


Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn 
        195                 200                 205             


Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His 
    210                 215                 220                 


Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
225                 230                 235                 240 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                245                 250                 255     


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
            260                 265                 270         


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        275                 280                 285             


Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
    290                 295                 300                 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
305                 310                 315                 320 


Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
                325                 330                 335     


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
            340                 345                 350         


Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
        355                 360                 365             


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
    370                 375                 380                 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
385                 390                 395                 400 


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
                405                 410                 415     


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            420                 425                 430         


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445         


<210>  21
<211>  1341
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  NOV0308 DNA Heavy Chain

<400>  21
caggtgcagc tggtgcagtc aggcgccgaa gtgaagaaac ccggctctag cgtgaaagtc       60

agctgtaaag ctagtggcgg caccttctct agctacgcta ttagctgggt cagacaggcc      120

ccaggtcagg gcctggagtg gatgggcgga attatccccg tgctgggcac cgctaactac      180

gctcagaaat ttcagggtag agtgactatc accgccgacg agtctactag caccgcctat      240

atggaactgt ctagcctgag atcagaggac accgccgtct actactgcgc tagagtgcct      300

accgactact tcgactactg gggtcagggc accctggtca ccgtgtctag cgctagcact      360

aagggcccaa gtgtgtttcc cctggccccc agcagcaagt ctacttccgg cggaactgct      420

gccctgggtt gcctggtgaa ggactacttc cccgagcccg tgacagtgtc ctggaactct      480

ggggctctga cttccggcgt gcacaccttc cccgccgtgc tgcagagcag cggcctgtac      540

agcctgagca gcgtggtgac agtgccctcc agctctctgg gaacccagac ctatatctgc      600

aacgtgaacc acaagcccag caacaccaag gtggacaaga gagtggagcc caagagctgc      660

gacaagaccc acacctgccc cccctgccca gctccagaac tgctgggagg gccttccgtg      720

ttcctgttcc cccccaagcc caaggacacc ctgatgatca gcaggacccc cgaggtgacc      780

tgcgtggtgg tggacgtgtc ccacgaggac ccagaggtga agttcaactg gtacgtggac      840

ggcgtggagg tgcacaacgc caagaccaag cccagagagg agcagtacaa cagcacctac      900

agggtggtgt ccgtgctgac cgtgctgcac caggactggc tgaacggcaa agaatacaag      960

tgcaaagtct ccaacaaggc cctgccagcc ccaatcgaaa agacaatcag caaggccaag     1020

ggccagccac gggagcccca ggtgtacacc ctgcccccca gccgggagga gatgaccaag     1080

aaccaggtgt ccctgacctg tctggtgaag ggcttctacc ccagcgatat cgccgtggag     1140

tgggagagca acggccagcc cgagaacaac tacaagacca cccccccagt gctggacagc     1200

gacggcagct tcttcctgta cagcaagctg accgtggaca agtccaggtg gcagcagggc     1260

aacgtgttca gctgcagcgt gatgcacgag gccctgcaca accactacac ccagaagtcc     1320

ctgagcctga gccccggcaa g                                               1341


<210>  22
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NOV0308 LCDR1 (Kabat)

<400>  22

Ser Gly Asp Asn Leu Gly Ser Lys Tyr Val His 
1               5                   10      


<210>  23
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NOV0308 LCDR2 (Kabat)

<400>  23

Asp Asp Asn Lys Arg Pro Ser 
1               5           


<210>  24
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NOV0308 LCDR3 (Kabat)

<400>  24

Gln Ser Trp Thr Leu Gly Asn Trp Val 
1               5                   


<210>  25
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NOV0308 VL

<400>  25

Asp Ile Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ser Pro Gly Gln 
1               5                   10                  15      


Thr Ala Ser Ile Thr Cys Ser Gly Asp Asn Leu Gly Ser Lys Tyr Val 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr 
        35                  40                  45              


Asp Asp Asn Lys Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  


Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Gly Thr Gln Ala Glu 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Trp Thr Leu Gly Asn Trp Val 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105     


<210>  26
<211>  318
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  NOV0308 DNA VL

<400>  26
gatatcgagc tgactcagcc ccctagcgtc agcgtcagcc ctggtcagac cgcctctatc       60

acctgtagcg gcgataacct gggctctaaa tacgtgcact ggtatcagca gaagcccggt      120

caggcccccg tgctggtgat ctacgacgat aacaagcggc ctagcggaat ccccgagcgg      180

tttagcggct ctaatagcgg taacaccgct accctgacta ttagcggcac tcaggccgag      240

gacgaggccg actactactg tcagtcctgg accctgggca actgggtgtt cggcggaggc      300

actaagctga ccgtgctg                                                    318


<210>  27
<211>  212
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NOV0308 Light Chain

<400>  27

Asp Ile Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ser Pro Gly Gln 
1               5                   10                  15      


Thr Ala Ser Ile Thr Cys Ser Gly Asp Asn Leu Gly Ser Lys Tyr Val 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr 
        35                  40                  45              


Asp Asp Asn Lys Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  


Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Gly Thr Gln Ala Glu 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Trp Thr Leu Gly Asn Trp Val 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln Pro Lys Ala Ala 
            100                 105                 110         


Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu Leu Gln Ala Asn 
        115                 120                 125             


Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr Pro Gly Ala Val 
    130                 135                 140                 


Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys Ala Gly Val Glu 
145                 150                 155                 160 


Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr Ala Ala Ser Ser 
                165                 170                 175     


Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His Arg Ser Tyr Ser 
            180                 185                 190         


Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys Thr Val Ala Pro 
        195                 200                 205             


Thr Glu Cys Ser 
    210         


<210>  28
<211>  636
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  NOV0308 DNA Light Chain

<400>  28
gatatcgagc tgactcagcc ccctagcgtc agcgtcagcc ctggtcagac cgcctctatc       60

acctgtagcg gcgataacct gggctctaaa tacgtgcact ggtatcagca gaagcccggt      120

caggcccccg tgctggtgat ctacgacgat aacaagcggc ctagcggaat ccccgagcgg      180

tttagcggct ctaatagcgg taacaccgct accctgacta ttagcggcac tcaggccgag      240

gacgaggccg actactactg tcagtcctgg accctgggca actgggtgtt cggcggaggc      300

actaagctga ccgtgctggg tcagcctaag gctgccccca gcgtgaccct gttccccccc      360

agcagcgagg agctgcaggc caacaaggcc accctggtgt gcctgatcag cgacttctac      420

ccaggcgccg tgaccgtggc ctggaaggcc gacagcagcc ccgtgaaggc cggcgtggag      480

accaccaccc ccagcaagca gagcaacaac aagtacgccg ccagcagcta cctgagcctg      540

acccccgagc agtggaagag ccacaggtcc tacagctgcc aggtgaccca cgagggcagc      600

accgtggaaa agaccgtggc cccaaccgag tgcagc                                636


<210>  29
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NOV0563 HCDR1 (Kabat)

<400>  29

Asp Asn Ala Ile Ser 
1               5   


<210>  30
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NOV0563 HCDR2 (Kabat)

<400>  30

Gly Ile Asn Pro Asp Phe Gly Trp Ala Asn Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  31
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NOV0563 HCDR3 (Kabat)

<400>  31

Asp Ser Ser Gly Met Gly Tyr 
1               5           


<210>  32
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NOV0563 VH

<400>  32

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Asp Asn 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Asn Pro Asp Phe Gly Trp Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Ser Ser Gly Met Gly Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  33
<211>  348
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  NOV0563 DNA VH

<400>  33
caggtgcagc tggtgcagtc aggcgccgaa gtgaagaaac ccggctctag cgtgaaagtc       60

agctgtaaag ctagtggcgg cacctttagc gataacgcta ttagctgggt cagacaggcc      120

ccaggtcagg gcctggagtg gatgggcggg attaaccccg acttcggctg ggctaactac      180

gctcagaaat ttcagggtag agtgactatc accgccgacg agtctactag caccgcctat      240

atggaactgt ctagcctgag atcagaggac accgccgtct actactgcgc tagggactct      300

agcggaatgg gctactgggg tcagggcacc ctggtcaccg tgtctagc                   348


<210>  34
<211>  446
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NOV0563 Heavy Chain

<400>  34

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Asp Asn 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Asn Pro Asp Phe Gly Trp Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Ser Ser Gly Met Gly Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
        115                 120                 125             


Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu 
    130                 135                 140                 


Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
145                 150                 155                 160 


Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 
                165                 170                 175     


Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu 
            180                 185                 190         


Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr 
        195                 200                 205             


Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr 
    210                 215                 220                 


Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe 
225                 230                 235                 240 


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
                245                 250                 255     


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
            260                 265                 270         


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
        275                 280                 285             


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
    290                 295                 300                 


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
305                 310                 315                 320 


Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
                325                 330                 335     


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
            340                 345                 350         


Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
        355                 360                 365             


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
    370                 375                 380                 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
385                 390                 395                 400 


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
                405                 410                 415     


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
            420                 425                 430         


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445     


<210>  35
<211>  1338
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  NOV0563 DNA Heavy Chain

<400>  35
caggtgcagc tggtgcagtc aggcgccgaa gtgaagaaac ccggctctag cgtgaaagtc       60

agctgtaaag ctagtggcgg cacctttagc gataacgcta ttagctgggt cagacaggcc      120

ccaggtcagg gcctggagtg gatgggcggg attaaccccg acttcggctg ggctaactac      180

gctcagaaat ttcagggtag agtgactatc accgccgacg agtctactag caccgcctat      240

atggaactgt ctagcctgag atcagaggac accgccgtct actactgcgc tagggactct      300

agcggaatgg gctactgggg tcagggcacc ctggtcaccg tgtctagcgc tagcactaag      360

ggcccaagtg tgtttcccct ggcccccagc agcaagtcta cttccggcgg aactgctgcc      420

ctgggttgcc tggtgaagga ctacttcccc gagcccgtga cagtgtcctg gaactctggg      480

gctctgactt ccggcgtgca caccttcccc gccgtgctgc agagcagcgg cctgtacagc      540

ctgagcagcg tggtgacagt gccctccagc tctctgggaa cccagaccta tatctgcaac      600

gtgaaccaca agcccagcaa caccaaggtg gacaagagag tggagcccaa gagctgcgac      660

aagacccaca cctgcccccc ctgcccagct ccagaactgc tgggagggcc ttccgtgttc      720

ctgttccccc ccaagcccaa ggacaccctg atgatcagca ggacccccga ggtgacctgc      780

gtggtggtgg acgtgtccca cgaggaccca gaggtgaagt tcaactggta cgtggacggc      840

gtggaggtgc acaacgccaa gaccaagccc agagaggagc agtacaacag cacctacagg      900

gtggtgtccg tgctgaccgt gctgcaccag gactggctga acggcaaaga atacaagtgc      960

aaagtctcca acaaggccct gccagcccca atcgaaaaga caatcagcaa ggccaagggc     1020

cagccacggg agccccaggt gtacaccctg ccccccagcc gggaggagat gaccaagaac     1080

caggtgtccc tgacctgtct ggtgaagggc ttctacccca gcgatatcgc cgtggagtgg     1140

gagagcaacg gccagcccga gaacaactac aagaccaccc ccccagtgct ggacagcgac     1200

ggcagcttct tcctgtacag caagctgacc gtggacaagt ccaggtggca gcagggcaac     1260

gtgttcagct gcagcgtgat gcacgaggcc ctgcacaacc actacaccca gaagtccctg     1320

agcctgagcc ccggcaag                                                   1338


<210>  36
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NOV0563 LCDR3 (Kabat)

<400>  36

Arg Ala Ser Gln Asp Ile Ser Ser Tyr Leu Asn 
1               5                   10      


<210>  37
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NOV0563 LCDR2 (Kabat)

<400>  37

Asp Ala Ser Thr Leu Gln Ser 
1               5           


<210>  38
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NOV0563 LCDR3 (Kabat)

<400>  38

Gln Gln Ser Gly His Trp Leu Ser Lys Thr 
1               5                   10  


<210>  39
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NOV0563 VL

<400>  39

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Ser Ser Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Gly His Trp Leu Ser 
                85                  90                  95      


Lys Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105             


<210>  40
<211>  324
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  NOV0563 DNA VL

<400>  40
gatattcaga tgactcagtc acctagtagc ctgagcgcta gtgtgggcga tagagtgact       60

atcacctgta gagcctctca ggatatctct agctacctga actggtatca gcagaagccc      120

ggtaaagccc ctaagctgct gatctacgac gcctctaccc tgcagtcagg cgtgccctct      180

aggtttagcg gtagcggtag tggcaccgac ttcaccctga ctatctctag cctgcagccc      240

gaggacttcg ctacctacta ctgtcagcag tcaggccact ggctgtctaa gaccttcggt      300

cagggcacta aggtcgagat taag                                             324


<210>  41
<211>  215
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NOV0563 Light Chain

<400>  41

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Ser Ser Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Gly His Trp Leu Ser 
                85                  90                  95      


Lys Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala 
            100                 105                 110         


Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser 
        115                 120                 125             


Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu 
    130                 135                 140                 


Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser 
145                 150                 155                 160 


Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu 
                165                 170                 175     


Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val 
            180                 185                 190         


Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys 
        195                 200                 205             


Ser Phe Asn Arg Gly Glu Cys 
    210                 215 


<210>  42
<211>  645
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  NOV0563 DNA Light Chain

<400>  42
gatattcaga tgactcagtc acctagtagc ctgagcgcta gtgtgggcga tagagtgact       60

atcacctgta gagcctctca ggatatctct agctacctga actggtatca gcagaagccc      120

ggtaaagccc ctaagctgct gatctacgac gcctctaccc tgcagtcagg cgtgccctct      180

aggtttagcg gtagcggtag tggcaccgac ttcaccctga ctatctctag cctgcagccc      240

gaggacttcg ctacctacta ctgtcagcag tcaggccact ggctgtctaa gaccttcggt      300

cagggcacta aggtcgagat taagcgtacg gtggccgctc ccagcgtgtt catcttcccc      360

cccagcgacg agcagctgaa gagcggcacc gccagcgtgg tgtgcctgct gaacaacttc      420

tacccccggg aggccaaggt gcagtggaag gtggacaacg ccctgcagag cggcaacagc      480

caggagagcg tcaccgagca ggacagcaag gactccacct acagcctgag cagcaccctg      540

accctgagca aggccgacta cgagaagcat aaggtgtacg cctgcgaggt gacccaccag      600

ggcctgtcca gccccgtgac caagagcttc aacaggggcg agtgc                      645


<210>  43
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NOV1216 HCDR3 (Kabat)

<400>  43

Asp Tyr Ala Ile Ser 
1               5   


<210>  44
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NOV1216 HCDR2 (Kabat)

<400>  44

Gly Ile Ile Pro Ala Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  45
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NOV1216 HCDR3 (Kabat)

<400>  45

Glu Gln Asp Pro Glu Tyr Gly Tyr Gly Gly Tyr Pro Tyr Glu Ala Met 
1               5                   10                  15      


Asp Val 
        


<210>  46
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NOV1216 VH

<400>  46

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Arg Asp Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Ala Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Gln Asp Pro Glu Tyr Gly Tyr Gly Gly Tyr Pro Tyr Glu 
            100                 105                 110         


Ala Met Asp Val Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125         


<210>  47
<211>  381
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  NOV1216 DNA VH

<400>  47
caggtgcagc tggtgcagtc aggcgccgaa gtgaagaaac ccggctctag cgtgaaagtc       60

agctgtaaag ctagtggcgg cacctttaga gactacgcta ttagctgggt cagacaggcc      120

ccaggtcagg gcctggagtg gatgggcgga attatccccg ccttcggcac cgctaactac      180

gctcagaaat ttcagggtag agtgactatc accgccgacg agtctactag caccgcctat      240

atggaactgt ctagcctgag atcagaggac accgccgtct actactgcgc tagagagcag      300

gaccccgagt acggctacgg cggctacccc tacgaggcta tggacgtgtg gggtcagggc      360

accctggtca ccgtgtctag c                                                381


<210>  48
<211>  457
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NOV1216 Heavy chain

<400>  48

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Arg Asp Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Ala Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Gln Asp Pro Glu Tyr Gly Tyr Gly Gly Tyr Pro Tyr Glu 
            100                 105                 110         


Ala Met Asp Val Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala 
        115                 120                 125             


Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser 
    130                 135                 140                 


Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe 
145                 150                 155                 160 


Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly 
                165                 170                 175     


Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu 
            180                 185                 190         


Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr 
        195                 200                 205             


Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg 
    210                 215                 220                 


Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
225                 230                 235                 240 


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
                245                 250                 255     


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            260                 265                 270         


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
        275                 280                 285             


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    290                 295                 300                 


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
305                 310                 315                 320 


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                325                 330                 335     


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
            340                 345                 350         


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met 
        355                 360                 365             


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
    370                 375                 380                 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
385                 390                 395                 400 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
                405                 410                 415     


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
            420                 425                 430         


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
        435                 440                 445             


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    450                 455         


<210>  49
<211>  1371
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  NOV1216 DNA Heavy Chain

<400>  49
caggtgcagc tggtgcagtc aggcgccgaa gtgaagaaac ccggctctag cgtgaaagtc       60

agctgtaaag ctagtggcgg cacctttaga gactacgcta ttagctgggt cagacaggcc      120

ccaggtcagg gcctggagtg gatgggcgga attatccccg ccttcggcac cgctaactac      180

gctcagaaat ttcagggtag agtgactatc accgccgacg agtctactag caccgcctat      240

atggaactgt ctagcctgag atcagaggac accgccgtct actactgcgc tagagagcag      300

gaccccgagt acggctacgg cggctacccc tacgaggcta tggacgtgtg gggtcagggc      360

accctggtca ccgtgtctag cgctagcact aagggcccaa gtgtgtttcc cctggccccc      420

agcagcaagt ctacttccgg cggaactgct gccctgggtt gcctggtgaa ggactacttc      480

cccgagcccg tgacagtgtc ctggaactct ggggctctga cttccggcgt gcacaccttc      540

cccgccgtgc tgcagagcag cggcctgtac agcctgagca gcgtggtgac agtgccctcc      600

agctctctgg gaacccagac ctatatctgc aacgtgaacc acaagcccag caacaccaag      660

gtggacaaga gagtggagcc caagagctgc gacaagaccc acacctgccc cccctgccca      720

gctccagaac tgctgggagg gccttccgtg ttcctgttcc cccccaagcc caaggacacc      780

ctgatgatca gcaggacccc cgaggtgacc tgcgtggtgg tggacgtgtc ccacgaggac      840

ccagaggtga agttcaactg gtacgtggac ggcgtggagg tgcacaacgc caagaccaag      900

cccagagagg agcagtacaa cagcacctac agggtggtgt ccgtgctgac cgtgctgcac      960

caggactggc tgaacggcaa agaatacaag tgcaaagtct ccaacaaggc cctgccagcc     1020

ccaatcgaaa agacaatcag caaggccaag ggccagccac gggagcccca ggtgtacacc     1080

ctgcccccca gccgggagga gatgaccaag aaccaggtgt ccctgacctg tctggtgaag     1140

ggcttctacc ccagcgatat cgccgtggag tgggagagca acggccagcc cgagaacaac     1200

tacaagacca cccccccagt gctggacagc gacggcagct tcttcctgta cagcaagctg     1260

accgtggaca agtccaggtg gcagcagggc aacgtgttca gctgcagcgt gatgcacgag     1320

gccctgcaca accactacac ccagaagtcc ctgagcctga gccccggcaa g              1371


<210>  50
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NOV1216 LCDR1 (Kabat)

<400>  50

Ser Gly Asp Asn Ile Pro Gln His Ser Val His 
1               5                   10      


<210>  51
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NOV1216 LCDR2 (Kabat)

<400>  51

Asp Asp Thr Glu Arg Pro Ser 
1               5           


<210>  52
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NOV1216 LCDR3 (Kabat)

<400>  52

Ser Ser Trp Asp Ser Ser Met Asp Ser Val Val 
1               5                   10      


<210>  53
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NOV1216 VL

<400>  53

Ser Tyr Glu Leu Thr Gln Pro Leu Ser Val Ser Val Ala Leu Gly Gln 
1               5                   10                  15      


Thr Ala Arg Ile Thr Cys Ser Gly Asp Asn Ile Pro Gln His Ser Val 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr 
        35                  40                  45              


Asp Asp Thr Glu Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  


Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Arg Ala Gln Ala Gly 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Trp Asp Ser Ser Met Asp Ser 
                85                  90                  95      


Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105             


<210>  54
<211>  324
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  NOV1216 DNA VL

<400>  54
agctacgagc tgactcagcc cctgagcgtc agcgtggccc tgggtcagac cgctagaatc       60

acctgtagcg gcgataatat ccctcagcac tcagtgcact ggtatcagca gaagcccggt      120

caggcccccg tgctggtgat ctacgacgac accgagcggc ctagcggaat ccccgagcgg      180

tttagcggct ctaatagcgg taacaccgct accctgacta tctctagggc tcaggccggc      240

gacgaggccg actactactg ctctagctgg gatagctcta tggatagcgt ggtgttcggc      300

ggaggcacta agctgaccgt gctg                                             324


<210>  55
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NOV1216 Light Chain

<400>  55

Ser Tyr Glu Leu Thr Gln Pro Leu Ser Val Ser Val Ala Leu Gly Gln 
1               5                   10                  15      


Thr Ala Arg Ile Thr Cys Ser Gly Asp Asn Ile Pro Gln His Ser Val 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr 
        35                  40                  45              


Asp Asp Thr Glu Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  


Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Arg Ala Gln Ala Gly 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Trp Asp Ser Ser Met Asp Ser 
                85                  90                  95      


Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln Pro Lys 
            100                 105                 110         


Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu Leu Gln 
        115                 120                 125             


Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr Pro Gly 
    130                 135                 140                 


Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys Ala Gly 
145                 150                 155                 160 


Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr Ala Ala 
                165                 170                 175     


Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His Arg Ser 
            180                 185                 190         


Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys Thr Val 
        195                 200                 205             


Ala Pro Thr Glu Cys Ser 
    210                 


<210>  56
<211>  642
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  NOV1216 DNA Light Chain

<400>  56
agctacgagc tgactcagcc cctgagcgtc agcgtggccc tgggtcagac cgctagaatc       60

acctgtagcg gcgataatat ccctcagcac tcagtgcact ggtatcagca gaagcccggt      120

caggcccccg tgctggtgat ctacgacgac accgagcggc ctagcggaat ccccgagcgg      180

tttagcggct ctaatagcgg taacaccgct accctgacta tctctagggc tcaggccggc      240

gacgaggccg actactactg ctctagctgg gatagctcta tggatagcgt ggtgttcggc      300

ggaggcacta agctgaccgt gctgggtcag cctaaggctg cccccagcgt gaccctgttc      360

ccccccagca gcgaggagct gcaggccaac aaggccaccc tggtgtgcct gatcagcgac      420

ttctacccag gcgccgtgac cgtggcctgg aaggccgaca gcagccccgt gaaggccggc      480

gtggagacca ccacccccag caagcagagc aacaacaagt acgccgccag cagctacctg      540

agcctgaccc ccgagcagtg gaagagccac aggtcctaca gctgccaggt gacccacgag      600

ggcagcaccg tggaaaagac cgtggcccca accgagtgca gc                         642


<210>  57
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NOV1218 HCDR1 (Kabat)

<400>  57

Thr His Gly Leu His 
1               5   


<210>  58
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NOV1218 HCDR2 (Kabat)

<400>  58

Ala Ile Ser Tyr Asp Ala Ser Glu Thr Asn Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  59
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NOV1218 HCDR3 (Kabat)

<400>  59

Glu Ser Ile Gly Gly Tyr Phe Asp Tyr 
1               5                   


<210>  60
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NOV1218 VH

<400>  60

Gln Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Pro Thr His 
            20                  25                  30          


Gly Leu His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Tyr Asp Ala Ser Glu Thr Asn Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Ser Ile Gly Gly Tyr Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  61
<211>  354
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  NOV1218 DNA VH

<400>  61
caggtgcagc tgctggaatc aggcggcgga ctggtgcagc ctggcggtag cctgagactg       60

agctgcgctg ctagtggctt caccttccct actcacggcc tgcactgggt cagacaggcc      120

cctggtaaag gcctggagtg ggtcagcgct attagctacg acgctagtga aactaactac      180

gccgatagcg tgaagggccg gttcactatc tctagggata actctaagaa caccctgtac      240

ctgcagatga atagcctgag agccgaggac accgccgtct actactgcgc tagagagtct      300

atcggcggct acttcgacta ctggggtcag ggcaccctgg tcaccgtgtc tagc            354


<210>  62
<211>  448
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NOV1218 Heavy Chain

<400>  62

Gln Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Pro Thr His 
            20                  25                  30          


Gly Leu His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Tyr Asp Ala Ser Glu Thr Asn Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Ser Ile Gly Gly Tyr Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
        115                 120                 125             


Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly 
    130                 135                 140                 


Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
145                 150                 155                 160 


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
                165                 170                 175     


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
            180                 185                 190         


Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser 
        195                 200                 205             


Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp Lys Thr 
    210                 215                 220                 


His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser 
225                 230                 235                 240 


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
                245                 250                 255     


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
            260                 265                 270         


Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
        275                 280                 285             


Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 
    290                 295                 300                 


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
305                 310                 315                 320 


Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 
                325                 330                 335     


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
            340                 345                 350         


Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys 
        355                 360                 365             


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
    370                 375                 380                 


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
385                 390                 395                 400 


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
                405                 410                 415     


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
            420                 425                 430         


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445             


<210>  63
<211>  1344
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  NOV1218 DNA Heavy Chain

<400>  63
caggtgcagc tgctggaatc aggcggcgga ctggtgcagc ctggcggtag cctgagactg       60

agctgcgctg ctagtggctt caccttccct actcacggcc tgcactgggt cagacaggcc      120

cctggtaaag gcctggagtg ggtcagcgct attagctacg acgctagtga aactaactac      180

gccgatagcg tgaagggccg gttcactatc tctagggata actctaagaa caccctgtac      240

ctgcagatga atagcctgag agccgaggac accgccgtct actactgcgc tagagagtct      300

atcggcggct acttcgacta ctggggtcag ggcaccctgg tcaccgtgtc tagcgctagc      360

actaagggcc caagtgtgtt tcccctggcc cccagcagca agtctacttc cggcggaact      420

gctgccctgg gttgcctggt gaaggactac ttccccgagc ccgtgacagt gtcctggaac      480

tctggggctc tgacttccgg cgtgcacacc ttccccgccg tgctgcagag cagcggcctg      540

tacagcctga gcagcgtggt gacagtgccc tccagctctc tgggaaccca gacctatatc      600

tgcaacgtga accacaagcc cagcaacacc aaggtggaca agagagtgga gcccaagagc      660

tgcgacaaga cccacacctg ccccccctgc ccagctccag aactgctggg agggccttcc      720

gtgttcctgt tcccccccaa gcccaaggac accctgatga tcagcaggac ccccgaggtg      780

acctgcgtgg tggtggacgt gtcccacgag gacccagagg tgaagttcaa ctggtacgtg      840

gacggcgtgg aggtgcacaa cgccaagacc aagcccagag aggagcagta caacagcacc      900

tacagggtgg tgtccgtgct gaccgtgctg caccaggact ggctgaacgg caaagaatac      960

aagtgcaaag tctccaacaa ggccctgcca gccccaatcg aaaagacaat cagcaaggcc     1020

aagggccagc cacgggagcc ccaggtgtac accctgcccc ccagccggga ggagatgacc     1080

aagaaccagg tgtccctgac ctgtctggtg aagggcttct accccagcga tatcgccgtg     1140

gagtgggaga gcaacggcca gcccgagaac aactacaaga ccaccccccc agtgctggac     1200

agcgacggca gcttcttcct gtacagcaag ctgaccgtgg acaagtccag gtggcagcag     1260

ggcaacgtgt tcagctgcag cgtgatgcac gaggccctgc acaaccacta cacccagaag     1320

tccctgagcc tgagccccgg caag                                            1344


<210>  64
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NOV1218 LCDR1 (Kabat)

<400>  64

Ser Gly Asp Ala Leu Gly Lys Asn Thr Val Ser 
1               5                   10      


<210>  65
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NOV1218 LCDR2 (Kabat)

<400>  65

Asp Asp Thr Asp Arg Pro Ser 
1               5           


<210>  66
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NOV1218 LCDR3 (Kabat)

<400>  66

Ser Ser Thr Asp Leu Ser Thr Val Val 
1               5                   


<210>  67
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NOV1218 VL

<400>  67

Ser Tyr Glu Leu Thr Gln Pro Leu Ser Val Ser Val Ala Leu Gly Gln 
1               5                   10                  15      


Thr Ala Arg Ile Thr Cys Ser Gly Asp Ala Leu Gly Lys Asn Thr Val 
            20                  25                  30          


Ser Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr 
        35                  40                  45              


Asp Asp Thr Asp Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  


Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Arg Ala Gln Ala Gly 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Thr Asp Leu Ser Thr Val Val 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105     


<210>  68
<211>  318
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  NOV1218 DNA VL

<400>  68
agctacgagc tgactcagcc cctgagcgtc agcgtggccc tgggtcagac cgctagaatc       60

acctgtagcg gcgacgccct gggtaaaaac accgtcagct ggtatcagca gaagcccggt      120

caggcccccg tgctggtgat ctacgacgac accgatagac ctagcggaat ccccgagcgg      180

tttagcggct ctaatagcgg taacaccgct accctgacta tctctagggc tcaggccggc      240

gacgaggccg actactactg ctctagcacc gacctgagca ccgtggtgtt cggcggaggc      300

actaagctga ccgtgctg                                                    318


<210>  69
<211>  212
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NOV1218 Light Chain

<400>  69

Ser Tyr Glu Leu Thr Gln Pro Leu Ser Val Ser Val Ala Leu Gly Gln 
1               5                   10                  15      


Thr Ala Arg Ile Thr Cys Ser Gly Asp Ala Leu Gly Lys Asn Thr Val 
            20                  25                  30          


Ser Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr 
        35                  40                  45              


Asp Asp Thr Asp Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  


Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Arg Ala Gln Ala Gly 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Thr Asp Leu Ser Thr Val Val 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln Pro Lys Ala Ala 
            100                 105                 110         


Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu Leu Gln Ala Asn 
        115                 120                 125             


Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr Pro Gly Ala Val 
    130                 135                 140                 


Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys Ala Gly Val Glu 
145                 150                 155                 160 


Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr Ala Ala Ser Ser 
                165                 170                 175     


Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His Arg Ser Tyr Ser 
            180                 185                 190         


Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys Thr Val Ala Pro 
        195                 200                 205             


Thr Glu Cys Ser 
    210         


<210>  70
<211>  636
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  NOV1218 DNA Light Chain

<400>  70
agctacgagc tgactcagcc cctgagcgtc agcgtggccc tgggtcagac cgctagaatc       60

acctgtagcg gcgacgccct gggtaaaaac accgtcagct ggtatcagca gaagcccggt      120

caggcccccg tgctggtgat ctacgacgac accgatagac ctagcggaat ccccgagcgg      180

tttagcggct ctaatagcgg taacaccgct accctgacta tctctagggc tcaggccggc      240

gacgaggccg actactactg ctctagcacc gacctgagca ccgtggtgtt cggcggaggc      300

actaagctga ccgtgctggg tcagcctaag gctgccccca gcgtgaccct gttccccccc      360

agcagcgagg agctgcaggc caacaaggcc accctggtgt gcctgatcag cgacttctac      420

ccaggcgccg tgaccgtggc ctggaaggcc gacagcagcc ccgtgaaggc cggcgtggag      480

accaccaccc ccagcaagca gagcaacaac aagtacgccg ccagcagcta cctgagcctg      540

acccccgagc agtggaagag ccacaggtcc tacagctgcc aggtgaccca cgagggcagc      600

accgtggaaa agaccgtggc cccaaccgag tgcagc                                636


<210>  71
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NOV1219 HCDR1 (Kabat)

<400>  71

Thr His Gly Leu His 
1               5   


<210>  72
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NOV1219 HCDR2 (Kabat)

<400>  72

Ala Ile Ser Tyr Glu Gly Ser Glu Thr Asn Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  73
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NOV1219 HCDR3 (Kabat)

<400>  73

Glu Ser Ile Gly Gly Tyr Phe Asp Tyr 
1               5                   


<210>  74
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NOV1219 VH

<400>  74

Gln Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Pro Thr His 
            20                  25                  30          


Gly Leu His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Tyr Glu Gly Ser Glu Thr Asn Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Ser Ile Gly Gly Tyr Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  75
<211>  354
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  NOV1219 DNA VH

<400>  75
caggtgcagc tgctggaatc aggcggcgga ctggtgcagc ctggcggtag cctgagactg       60

agctgcgctg ctagtggctt caccttccct actcacggcc tgcactgggt cagacaggcc      120

cctggtaaag gcctggagtg ggtcagcgct attagctacg agggtagcga gactaactac      180

gccgatagcg tgaagggccg gttcactatc tctagggata actctaagaa caccctgtac      240

ctgcagatga atagcctgag agccgaggac accgccgtct actactgcgc tagagagtct      300

atcggcggct acttcgacta ctggggtcag ggcaccctgg tcaccgtgtc tagc            354


<210>  76
<211>  448
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NOV1219 Heavy Chain

<400>  76

Gln Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Pro Thr His 
            20                  25                  30          


Gly Leu His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Tyr Glu Gly Ser Glu Thr Asn Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Ser Ile Gly Gly Tyr Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
        115                 120                 125             


Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly 
    130                 135                 140                 


Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
145                 150                 155                 160 


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
                165                 170                 175     


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
            180                 185                 190         


Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser 
        195                 200                 205             


Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp Lys Thr 
    210                 215                 220                 


His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser 
225                 230                 235                 240 


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
                245                 250                 255     


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
            260                 265                 270         


Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
        275                 280                 285             


Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 
    290                 295                 300                 


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
305                 310                 315                 320 


Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 
                325                 330                 335     


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
            340                 345                 350         


Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys 
        355                 360                 365             


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
    370                 375                 380                 


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
385                 390                 395                 400 


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
                405                 410                 415     


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
            420                 425                 430         


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445             


<210>  77
<211>  1344
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  NOV1219 DNA Heavy Chain

<400>  77
caggtgcagc tgctggaatc aggcggcgga ctggtgcagc ctggcggtag cctgagactg       60

agctgcgctg ctagtggctt caccttccct actcacggcc tgcactgggt cagacaggcc      120

cctggtaaag gcctggagtg ggtcagcgct attagctacg agggtagcga gactaactac      180

gccgatagcg tgaagggccg gttcactatc tctagggata actctaagaa caccctgtac      240

ctgcagatga atagcctgag agccgaggac accgccgtct actactgcgc tagagagtct      300

atcggcggct acttcgacta ctggggtcag ggcaccctgg tcaccgtgtc tagcgctagc      360

actaagggcc caagtgtgtt tcccctggcc cccagcagca agtctacttc cggcggaact      420

gctgccctgg gttgcctggt gaaggactac ttccccgagc ccgtgacagt gtcctggaac      480

tctggggctc tgacttccgg cgtgcacacc ttccccgccg tgctgcagag cagcggcctg      540

tacagcctga gcagcgtggt gacagtgccc tccagctctc tgggaaccca gacctatatc      600

tgcaacgtga accacaagcc cagcaacacc aaggtggaca agagagtgga gcccaagagc      660

tgcgacaaga cccacacctg ccccccctgc ccagctccag aactgctggg agggccttcc      720

gtgttcctgt tcccccccaa gcccaaggac accctgatga tcagcaggac ccccgaggtg      780

acctgcgtgg tggtggacgt gtcccacgag gacccagagg tgaagttcaa ctggtacgtg      840

gacggcgtgg aggtgcacaa cgccaagacc aagcccagag aggagcagta caacagcacc      900

tacagggtgg tgtccgtgct gaccgtgctg caccaggact ggctgaacgg caaagaatac      960

aagtgcaaag tctccaacaa ggccctgcca gccccaatcg aaaagacaat cagcaaggcc     1020

aagggccagc cacgggagcc ccaggtgtac accctgcccc ccagccggga ggagatgacc     1080

aagaaccagg tgtccctgac ctgtctggtg aagggcttct accccagcga tatcgccgtg     1140

gagtgggaga gcaacggcca gcccgagaac aactacaaga ccaccccccc agtgctggac     1200

agcgacggca gcttcttcct gtacagcaag ctgaccgtgg acaagtccag gtggcagcag     1260

ggcaacgtgt tcagctgcag cgtgatgcac gaggccctgc acaaccacta cacccagaag     1320

tccctgagcc tgagccccgg caag                                            1344


<210>  78
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NOV1219 LCDR3 (Kabat)

<400>  78

Ser Gly Asp Ala Leu Gly Lys Asn Thr Val Ser 
1               5                   10      


<210>  79
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NOV1219 LCDR2 (Kabat)

<400>  79

Asp Asp Thr Asp Arg Pro Ser 
1               5           


<210>  80
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NOV1219 LCDR3 (Kabat)

<400>  80

Ser Ser Thr Asp Leu Ser Thr Val Val 
1               5                   


<210>  81
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NOV1219 VL

<400>  81

Ser Tyr Glu Leu Thr Gln Pro Leu Ser Val Ser Val Ala Leu Gly Gln 
1               5                   10                  15      


Thr Ala Arg Ile Thr Cys Ser Gly Asp Ala Leu Gly Lys Asn Thr Val 
            20                  25                  30          


Ser Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr 
        35                  40                  45              


Asp Asp Thr Asp Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  


Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Arg Ala Gln Ala Gly 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Thr Asp Leu Ser Thr Val Val 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105     


<210>  82
<211>  318
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  NOV1219 DNA VL

<400>  82
agctacgagc tgactcagcc cctgagcgtc agcgtggccc tgggtcagac cgctagaatc       60

acctgtagcg gcgacgccct gggtaaaaac accgtcagct ggtatcagca gaagcccggt      120

caggcccccg tgctggtgat ctacgacgac accgatagac ctagcggaat ccccgagcgg      180

tttagcggct ctaatagcgg taacaccgct accctgacta tctctagggc tcaggccggc      240

gacgaggccg actactactg ctctagcacc gacctgagca ccgtggtgtt cggcggaggc      300

actaagctga ccgtgctg                                                    318


<210>  83
<211>  212
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NOV1219 Light Chain

<400>  83

Ser Tyr Glu Leu Thr Gln Pro Leu Ser Val Ser Val Ala Leu Gly Gln 
1               5                   10                  15      


Thr Ala Arg Ile Thr Cys Ser Gly Asp Ala Leu Gly Lys Asn Thr Val 
            20                  25                  30          


Ser Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr 
        35                  40                  45              


Asp Asp Thr Asp Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  


Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Arg Ala Gln Ala Gly 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Thr Asp Leu Ser Thr Val Val 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln Pro Lys Ala Ala 
            100                 105                 110         


Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu Leu Gln Ala Asn 
        115                 120                 125             


Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr Pro Gly Ala Val 
    130                 135                 140                 


Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys Ala Gly Val Glu 
145                 150                 155                 160 


Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr Ala Ala Ser Ser 
                165                 170                 175     


Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His Arg Ser Tyr Ser 
            180                 185                 190         


Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys Thr Val Ala Pro 
        195                 200                 205             


Thr Glu Cys Ser 
    210         


<210>  84
<211>  636
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  NOV1219 DNA Light Chain

<400>  84
agctacgagc tgactcagcc cctgagcgtc agcgtggccc tgggtcagac cgctagaatc       60

acctgtagcg gcgacgccct gggtaaaaac accgtcagct ggtatcagca gaagcccggt      120

caggcccccg tgctggtgat ctacgacgac accgatagac ctagcggaat ccccgagcgg      180

tttagcggct ctaatagcgg taacaccgct accctgacta tctctagggc tcaggccggc      240

gacgaggccg actactactg ctctagcacc gacctgagca ccgtggtgtt cggcggaggc      300

actaagctga ccgtgctggg tcagcctaag gctgccccca gcgtgaccct gttccccccc      360

agcagcgagg agctgcaggc caacaaggcc accctggtgt gcctgatcag cgacttctac      420

ccaggcgccg tgaccgtggc ctggaaggcc gacagcagcc ccgtgaaggc cggcgtggag      480

accaccaccc ccagcaagca gagcaacaac aagtacgccg ccagcagcta cctgagcctg      540

acccccgagc agtggaagag ccacaggtcc tacagctgcc aggtgaccca cgagggcagc      600

accgtggaaa agaccgtggc cccaaccgag tgcagc                                636


<210>  85
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NOV2106 HCDR1 (Kabat)

<400>  85

Asp Tyr Ala Ile Ser 
1               5   


<210>  86
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NOV2106 HCDR2 (Kabat)

<400>  86

Gly Ile Ile Pro Ala Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  87
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NOV2106 HCDR3 (Kabat)

<400>  87

Glu Gln Asp Pro Glu Phe Gly Tyr Gly Gly Tyr Pro Tyr Glu Ala Met 
1               5                   10                  15      


Asp Val 
        


<210>  88
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NOV2106 VH

<400>  88

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Arg Asp Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Ala Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Gln Asp Pro Glu Phe Gly Tyr Gly Gly Tyr Pro Tyr Glu 
            100                 105                 110         


Ala Met Asp Val Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125         


<210>  89
<211>  381
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  NOV2106 DNA VH

<400>  89
caggtgcagc tggtgcagtc aggcgccgaa gtgaagaaac ccggctctag cgtgaaagtc       60

agctgtaaag ctagtggcgg cacctttaga gactacgcta ttagctgggt cagacaggcc      120

ccaggtcagg gcctggagtg gatgggcgga attatccccg ccttcggcac cgctaactac      180

gctcagaaat ttcagggtag agtgactatc accgccgacg agtctactag caccgcctat      240

atggaactgt ctagcctgag atcagaggac accgccgtct actactgcgc tagagagcag      300

gaccccgagt tcggctacgg cggctacccc tacgaggcta tggacgtgtg gggtcagggc      360

accctggtca ccgtgtctag c                                                381


<210>  90
<211>  457
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NOV2106 Heavy Chain

<400>  90

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Arg Asp Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Ala Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Gln Asp Pro Glu Phe Gly Tyr Gly Gly Tyr Pro Tyr Glu 
            100                 105                 110         


Ala Met Asp Val Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala 
        115                 120                 125             


Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser 
    130                 135                 140                 


Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe 
145                 150                 155                 160 


Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly 
                165                 170                 175     


Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu 
            180                 185                 190         


Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr 
        195                 200                 205             


Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg 
    210                 215                 220                 


Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
225                 230                 235                 240 


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
                245                 250                 255     


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            260                 265                 270         


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
        275                 280                 285             


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    290                 295                 300                 


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
305                 310                 315                 320 


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                325                 330                 335     


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
            340                 345                 350         


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met 
        355                 360                 365             


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
    370                 375                 380                 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
385                 390                 395                 400 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
                405                 410                 415     


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
            420                 425                 430         


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
        435                 440                 445             


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    450                 455         


<210>  91
<211>  1371
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  NOV2106 DNA Heavy Chain

<400>  91
caggtgcagc tggtgcagtc aggcgccgaa gtgaagaaac ccggctctag cgtgaaagtc       60

agctgtaaag ctagtggcgg cacctttaga gactacgcta ttagctgggt cagacaggcc      120

ccaggtcagg gcctggagtg gatgggcgga attatccccg ccttcggcac cgctaactac      180

gctcagaaat ttcagggtag agtgactatc accgccgacg agtctactag caccgcctat      240

atggaactgt ctagcctgag atcagaggac accgccgtct actactgcgc tagagagcag      300

gaccccgagt tcggctacgg cggctacccc tacgaggcta tggacgtgtg gggtcagggc      360

accctggtca ccgtgtctag cgctagcact aagggcccaa gtgtgtttcc cctggccccc      420

agcagcaagt ctacttccgg cggaactgct gccctgggtt gcctggtgaa ggactacttc      480

cccgagcccg tgacagtgtc ctggaactct ggggctctga cttccggcgt gcacaccttc      540

cccgccgtgc tgcagagcag cggcctgtac agcctgagca gcgtggtgac agtgccctcc      600

agctctctgg gaacccagac ctatatctgc aacgtgaacc acaagcccag caacaccaag      660

gtggacaaga gagtggagcc caagagctgc gacaagaccc acacctgccc cccctgccca      720

gctccagaac tgctgggagg gccttccgtg ttcctgttcc cccccaagcc caaggacacc      780

ctgatgatca gcaggacccc cgaggtgacc tgcgtggtgg tggacgtgtc ccacgaggac      840

ccagaggtga agttcaactg gtacgtggac ggcgtggagg tgcacaacgc caagaccaag      900

cccagagagg agcagtacaa cagcacctac agggtggtgt ccgtgctgac cgtgctgcac      960

caggactggc tgaacggcaa agaatacaag tgcaaagtct ccaacaaggc cctgccagcc     1020

ccaatcgaaa agacaatcag caaggccaag ggccagccac gggagcccca ggtgtacacc     1080

ctgcccccca gccgggagga gatgaccaag aaccaggtgt ccctgacctg tctggtgaag     1140

ggcttctacc ccagcgatat cgccgtggag tgggagagca acggccagcc cgagaacaac     1200

tacaagacca cccccccagt gctggacagc gacggcagct tcttcctgta cagcaagctg     1260

accgtggaca agtccaggtg gcagcagggc aacgtgttca gctgcagcgt gatgcacgag     1320

gccctgcaca accactacac ccagaagtcc ctgagcctga gccccggcaa g              1371


<210>  92
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NOV2106 LCDR1 (Kabat)

<400>  92

Ser Gly Asp Asn Ile Pro Gln His Ser Val His 
1               5                   10      


<210>  93
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NOV2106 LCDR2 (Kabat)

<400>  93

Asp Asp Thr Glu Arg Pro Ser 
1               5           


<210>  94
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NOV2106 LCDR3 (Kabat)

<400>  94

Ser Ser Trp Asp Ser Ser Met Asp Ser Val Val 
1               5                   10      


<210>  95
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NOV2106 VL

<400>  95

Ser Tyr Glu Leu Thr Gln Pro Leu Ser Val Ser Val Ala Leu Gly Gln 
1               5                   10                  15      


Thr Ala Arg Ile Thr Cys Ser Gly Asp Asn Ile Pro Gln His Ser Val 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr 
        35                  40                  45              


Asp Asp Thr Glu Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  


Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Arg Ala Gln Ala Gly 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Trp Asp Ser Ser Met Asp Ser 
                85                  90                  95      


Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105             


<210>  96
<211>  324
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  NOV2106 DNA VL

<400>  96
agctacgagc tgactcagcc cctgagcgtc agcgtggccc tgggtcagac cgctagaatc       60

acctgtagcg gcgataatat ccctcagcac tcagtgcact ggtatcagca gaagcccggt      120

caggcccccg tgctggtgat ctacgacgac accgagcggc ctagcggaat ccccgagcgg      180

tttagcggct ctaatagcgg taacaccgct accctgacta tctctagggc tcaggccggc      240

gacgaggccg actactactg ctctagctgg gatagctcta tggatagcgt ggtgttcggc      300

ggaggcacta agctgaccgt gctg                                             324


<210>  97
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NOV2106 Light Chain

<400>  97

Ser Tyr Glu Leu Thr Gln Pro Leu Ser Val Ser Val Ala Leu Gly Gln 
1               5                   10                  15      


Thr Ala Arg Ile Thr Cys Ser Gly Asp Asn Ile Pro Gln His Ser Val 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr 
        35                  40                  45              


Asp Asp Thr Glu Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  


Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Arg Ala Gln Ala Gly 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Trp Asp Ser Ser Met Asp Ser 
                85                  90                  95      


Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln Pro Lys 
            100                 105                 110         


Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu Leu Gln 
        115                 120                 125             


Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr Pro Gly 
    130                 135                 140                 


Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys Ala Gly 
145                 150                 155                 160 


Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr Ala Ala 
                165                 170                 175     


Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His Arg Ser 
            180                 185                 190         


Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys Thr Val 
        195                 200                 205             


Ala Pro Thr Glu Cys Ser 
    210                 


<210>  98
<211>  642
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  NOV2106 DNA Light Chain

<400>  98
agctacgagc tgactcagcc cctgagcgtc agcgtggccc tgggtcagac cgctagaatc       60

acctgtagcg gcgataatat ccctcagcac tcagtgcact ggtatcagca gaagcccggt      120

caggcccccg tgctggtgat ctacgacgac accgagcggc ctagcggaat ccccgagcgg      180

tttagcggct ctaatagcgg taacaccgct accctgacta tctctagggc tcaggccggc      240

gacgaggccg actactactg ctctagctgg gatagctcta tggatagcgt ggtgttcggc      300

ggaggcacta agctgaccgt gctgggtcag cctaaggctg cccccagcgt gaccctgttc      360

ccccccagca gcgaggagct gcaggccaac aaggccaccc tggtgtgcct gatcagcgac      420

ttctacccag gcgccgtgac cgtggcctgg aaggccgaca gcagccccgt gaaggccggc      480

gtggagacca ccacccccag caagcagagc aacaacaagt acgccgccag cagctacctg      540

agcctgaccc ccgagcagtg gaagagccac aggtcctaca gctgccaggt gacccacgag      600

ggcagcaccg tggaaaagac cgtggcccca accgagtgca gc                         642


<210>  99
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NOV2107 HCDR1 (Kabat)

<400>  99

Asp Tyr Ala Ile Ser 
1               5   


<210>  100
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NOV2107 HCDR2 (Kabat)

<400>  100

Gly Ile Ile Pro Ala Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  101
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NOV2107 HCDR3 (Kabat)

<400>  101

Glu Gln Asp Pro Glu Ala Gly Tyr Gly Gly Tyr Pro Tyr Glu Ala Met 
1               5                   10                  15      


Asp Val 
        


<210>  102
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NOV2107 VH

<400>  102

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Arg Asp Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Ala Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Gln Asp Pro Glu Ala Gly Tyr Gly Gly Tyr Pro Tyr Glu 
            100                 105                 110         


Ala Met Asp Val Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125         


<210>  103
<211>  381
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  NOV2107 DNA VH

<400>  103
caggtgcagc tggtgcagtc aggcgccgaa gtgaagaaac ccggctctag cgtgaaagtc       60

agctgtaaag ctagtggcgg cacctttaga gactacgcta ttagctgggt cagacaggcc      120

ccaggtcagg gcctggagtg gatgggcgga attatccccg ccttcggcac cgctaactac      180

gctcagaaat ttcagggtag agtgactatc accgccgacg agtctactag caccgcctat      240

atggaactgt ctagcctgag atcagaggac accgccgtct actactgcgc tagagagcag      300

gaccccgagg ccggctacgg cggctacccc tacgaggcta tggacgtgtg gggtcagggc      360

accctggtca ccgtgtctag c                                                381


<210>  104
<211>  457
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NOV2107 Heavy Chain

<400>  104

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Arg Asp Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Ala Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Gln Asp Pro Glu Ala Gly Tyr Gly Gly Tyr Pro Tyr Glu 
            100                 105                 110         


Ala Met Asp Val Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala 
        115                 120                 125             


Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser 
    130                 135                 140                 


Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe 
145                 150                 155                 160 


Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly 
                165                 170                 175     


Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu 
            180                 185                 190         


Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr 
        195                 200                 205             


Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg 
    210                 215                 220                 


Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
225                 230                 235                 240 


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
                245                 250                 255     


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            260                 265                 270         


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
        275                 280                 285             


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    290                 295                 300                 


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
305                 310                 315                 320 


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                325                 330                 335     


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
            340                 345                 350         


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met 
        355                 360                 365             


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
    370                 375                 380                 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
385                 390                 395                 400 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
                405                 410                 415     


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
            420                 425                 430         


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
        435                 440                 445             


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    450                 455         


<210>  105
<211>  1371
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  NOV2107 DNA Heavy Chain

<400>  105
caggtgcagc tggtgcagtc aggcgccgaa gtgaagaaac ccggctctag cgtgaaagtc       60

agctgtaaag ctagtggcgg cacctttaga gactacgcta ttagctgggt cagacaggcc      120

ccaggtcagg gcctggagtg gatgggcgga attatccccg ccttcggcac cgctaactac      180

gctcagaaat ttcagggtag agtgactatc accgccgacg agtctactag caccgcctat      240

atggaactgt ctagcctgag atcagaggac accgccgtct actactgcgc tagagagcag      300

gaccccgagg ccggctacgg cggctacccc tacgaggcta tggacgtgtg gggtcagggc      360

accctggtca ccgtgtctag cgctagcact aagggcccaa gtgtgtttcc cctggccccc      420

agcagcaagt ctacttccgg cggaactgct gccctgggtt gcctggtgaa ggactacttc      480

cccgagcccg tgacagtgtc ctggaactct ggggctctga cttccggcgt gcacaccttc      540

cccgccgtgc tgcagagcag cggcctgtac agcctgagca gcgtggtgac agtgccctcc      600

agctctctgg gaacccagac ctatatctgc aacgtgaacc acaagcccag caacaccaag      660

gtggacaaga gagtggagcc caagagctgc gacaagaccc acacctgccc cccctgccca      720

gctccagaac tgctgggagg gccttccgtg ttcctgttcc cccccaagcc caaggacacc      780

ctgatgatca gcaggacccc cgaggtgacc tgcgtggtgg tggacgtgtc ccacgaggac      840

ccagaggtga agttcaactg gtacgtggac ggcgtggagg tgcacaacgc caagaccaag      900

cccagagagg agcagtacaa cagcacctac agggtggtgt ccgtgctgac cgtgctgcac      960

caggactggc tgaacggcaa agaatacaag tgcaaagtct ccaacaaggc cctgccagcc     1020

ccaatcgaaa agacaatcag caaggccaag ggccagccac gggagcccca ggtgtacacc     1080

ctgcccccca gccgggagga gatgaccaag aaccaggtgt ccctgacctg tctggtgaag     1140

ggcttctacc ccagcgatat cgccgtggag tgggagagca acggccagcc cgagaacaac     1200

tacaagacca cccccccagt gctggacagc gacggcagct tcttcctgta cagcaagctg     1260

accgtggaca agtccaggtg gcagcagggc aacgtgttca gctgcagcgt gatgcacgag     1320

gccctgcaca accactacac ccagaagtcc ctgagcctga gccccggcaa g              1371


<210>  106
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NOV2017 LCDR1 (Kabat)

<400>  106

Ser Gly Asp Asn Ile Pro Gln His Ser Val His 
1               5                   10      


<210>  107
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NOV2107 LCDR2 (Kabat)

<400>  107

Asp Asp Thr Glu Arg Pro Ser 
1               5           


<210>  108
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NOV2107 LCDR3 (Kabat)

<400>  108

Ser Ser Trp Asp Ser Ser Met Asp Ser Val Val 
1               5                   10      


<210>  109
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NOV2107 VL

<400>  109

Ser Tyr Glu Leu Thr Gln Pro Leu Ser Val Ser Val Ala Leu Gly Gln 
1               5                   10                  15      


Thr Ala Arg Ile Thr Cys Ser Gly Asp Asn Ile Pro Gln His Ser Val 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr 
        35                  40                  45              


Asp Asp Thr Glu Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  


Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Arg Ala Gln Ala Gly 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Trp Asp Ser Ser Met Asp Ser 
                85                  90                  95      


Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105             


<210>  110
<211>  324
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  NOV2107 DNA VL

<400>  110
agctacgagc tgactcagcc cctgagcgtc agcgtggccc tgggtcagac cgctagaatc       60

acctgtagcg gcgataatat ccctcagcac tcagtgcact ggtatcagca gaagcccggt      120

caggcccccg tgctggtgat ctacgacgac accgagcggc ctagcggaat ccccgagcgg      180

tttagcggct ctaatagcgg taacaccgct accctgacta tctctagggc tcaggccggc      240

gacgaggccg actactactg ctctagctgg gatagctcta tggatagcgt ggtgttcggc      300

ggaggcacta agctgaccgt gctg                                             324


<210>  111
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NOV2107 Light Chain

<400>  111

Ser Tyr Glu Leu Thr Gln Pro Leu Ser Val Ser Val Ala Leu Gly Gln 
1               5                   10                  15      


Thr Ala Arg Ile Thr Cys Ser Gly Asp Asn Ile Pro Gln His Ser Val 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr 
        35                  40                  45              


Asp Asp Thr Glu Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  


Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Arg Ala Gln Ala Gly 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Trp Asp Ser Ser Met Asp Ser 
                85                  90                  95      


Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln Pro Lys 
            100                 105                 110         


Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu Leu Gln 
        115                 120                 125             


Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr Pro Gly 
    130                 135                 140                 


Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys Ala Gly 
145                 150                 155                 160 


Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr Ala Ala 
                165                 170                 175     


Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His Arg Ser 
            180                 185                 190         


Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys Thr Val 
        195                 200                 205             


Ala Pro Thr Glu Cys Ser 
    210                 


<210>  112
<211>  642
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  NOV2107 DNA Light Chain

<400>  112
agctacgagc tgactcagcc cctgagcgtc agcgtggccc tgggtcagac cgctagaatc       60

acctgtagcg gcgataatat ccctcagcac tcagtgcact ggtatcagca gaagcccggt      120

caggcccccg tgctggtgat ctacgacgac accgagcggc ctagcggaat ccccgagcgg      180

tttagcggct ctaatagcgg taacaccgct accctgacta tctctagggc tcaggccggc      240

gacgaggccg actactactg ctctagctgg gatagctcta tggatagcgt ggtgttcggc      300

ggaggcacta agctgaccgt gctgggtcag cctaaggctg cccccagcgt gaccctgttc      360

ccccccagca gcgaggagct gcaggccaac aaggccaccc tggtgtgcct gatcagcgac      420

ttctacccag gcgccgtgac cgtggcctgg aaggccgaca gcagccccgt gaaggccggc      480

gtggagacca ccacccccag caagcagagc aacaacaagt acgccgccag cagctacctg      540

agcctgaccc ccgagcagtg gaagagccac aggtcctaca gctgccaggt gacccacgag      600

ggcagcaccg tggaaaagac cgtggcccca accgagtgca gc                         642


<210>  113
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NOV2108 HCDR1 (Kabat)

<400>  113

Asp Tyr Ala Ile Ser 
1               5   


<210>  114
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NOV2108 HCDR2 (Kabat)

<400>  114

Gly Ile Ile Pro Ala Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  115
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NOV2108 HCDR3 (Kabat)

<400>  115

Glu Gln Asp Pro Glu Ser Gly Tyr Gly Gly Tyr Pro Tyr Glu Ala Met 
1               5                   10                  15      


Asp Val 
        


<210>  116
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NOV2108 VH

<400>  116

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Arg Asp Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Ala Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Gln Asp Pro Glu Ser Gly Tyr Gly Gly Tyr Pro Tyr Glu 
            100                 105                 110         


Ala Met Asp Val Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125         


<210>  117
<211>  381
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  NOV2108 DNA VH

<400>  117
caggtgcagc tggtgcagtc aggcgccgaa gtgaagaaac ccggctctag cgtgaaagtc       60

agctgtaaag ctagtggcgg cacctttaga gactacgcta ttagctgggt cagacaggcc      120

ccaggtcagg gcctggagtg gatgggcgga attatccccg ccttcggcac cgctaactac      180

gctcagaaat ttcagggtag agtgactatc accgccgacg agtctactag caccgcctat      240

atggaactgt ctagcctgag atcagaggac accgccgtct actactgcgc tagagagcag      300

gaccccgagt ccggctacgg cggctacccc tacgaggcta tggacgtgtg gggtcagggc      360

accctggtca ccgtgtctag c                                                381


<210>  118
<211>  457
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NOV2108 Heavy Chain

<400>  118

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Arg Asp Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Ala Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Gln Asp Pro Glu Ser Gly Tyr Gly Gly Tyr Pro Tyr Glu 
            100                 105                 110         


Ala Met Asp Val Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala 
        115                 120                 125             


Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser 
    130                 135                 140                 


Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe 
145                 150                 155                 160 


Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly 
                165                 170                 175     


Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu 
            180                 185                 190         


Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr 
        195                 200                 205             


Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg 
    210                 215                 220                 


Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
225                 230                 235                 240 


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
                245                 250                 255     


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            260                 265                 270         


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
        275                 280                 285             


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    290                 295                 300                 


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
305                 310                 315                 320 


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                325                 330                 335     


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
            340                 345                 350         


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met 
        355                 360                 365             


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
    370                 375                 380                 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
385                 390                 395                 400 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
                405                 410                 415     


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
            420                 425                 430         


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
        435                 440                 445             


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    450                 455         


<210>  119
<211>  1371
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  NOV2108 DNA Heavy Chain

<400>  119
caggtgcagc tggtgcagtc aggcgccgaa gtgaagaaac ccggctctag cgtgaaagtc       60

agctgtaaag ctagtggcgg cacctttaga gactacgcta ttagctgggt cagacaggcc      120

ccaggtcagg gcctggagtg gatgggcgga attatccccg ccttcggcac cgctaactac      180

gctcagaaat ttcagggtag agtgactatc accgccgacg agtctactag caccgcctat      240

atggaactgt ctagcctgag atcagaggac accgccgtct actactgcgc tagagagcag      300

gaccccgagt ccggctacgg cggctacccc tacgaggcta tggacgtgtg gggtcagggc      360

accctggtca ccgtgtctag cgctagcact aagggcccaa gtgtgtttcc cctggccccc      420

agcagcaagt ctacttccgg cggaactgct gccctgggtt gcctggtgaa ggactacttc      480

cccgagcccg tgacagtgtc ctggaactct ggggctctga cttccggcgt gcacaccttc      540

cccgccgtgc tgcagagcag cggcctgtac agcctgagca gcgtggtgac agtgccctcc      600

agctctctgg gaacccagac ctatatctgc aacgtgaacc acaagcccag caacaccaag      660

gtggacaaga gagtggagcc caagagctgc gacaagaccc acacctgccc cccctgccca      720

gctccagaac tgctgggagg gccttccgtg ttcctgttcc cccccaagcc caaggacacc      780

ctgatgatca gcaggacccc cgaggtgacc tgcgtggtgg tggacgtgtc ccacgaggac      840

ccagaggtga agttcaactg gtacgtggac ggcgtggagg tgcacaacgc caagaccaag      900

cccagagagg agcagtacaa cagcacctac agggtggtgt ccgtgctgac cgtgctgcac      960

caggactggc tgaacggcaa agaatacaag tgcaaagtct ccaacaaggc cctgccagcc     1020

ccaatcgaaa agacaatcag caaggccaag ggccagccac gggagcccca ggtgtacacc     1080

ctgcccccca gccgggagga gatgaccaag aaccaggtgt ccctgacctg tctggtgaag     1140

ggcttctacc ccagcgatat cgccgtggag tgggagagca acggccagcc cgagaacaac     1200

tacaagacca cccccccagt gctggacagc gacggcagct tcttcctgta cagcaagctg     1260

accgtggaca agtccaggtg gcagcagggc aacgtgttca gctgcagcgt gatgcacgag     1320

gccctgcaca accactacac ccagaagtcc ctgagcctga gccccggcaa g              1371


<210>  120
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NOV2108 LCDR1 (Kabat)

<400>  120

Ser Gly Asp Asn Ile Pro Gln His Ser Val His 
1               5                   10      


<210>  121
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NOV2108 LCDR2 (Kabat)

<400>  121

Asp Asp Thr Glu Arg Pro Ser 
1               5           


<210>  122
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NOV2108 LCDR3 (Kabat)

<400>  122

Ser Ser Trp Asp Ser Ser Met Asp Ser Val Val 
1               5                   10      


<210>  123
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NOV2108 VL

<400>  123

Ser Tyr Glu Leu Thr Gln Pro Leu Ser Val Ser Val Ala Leu Gly Gln 
1               5                   10                  15      


Thr Ala Arg Ile Thr Cys Ser Gly Asp Asn Ile Pro Gln His Ser Val 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr 
        35                  40                  45              


Asp Asp Thr Glu Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  


Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Arg Ala Gln Ala Gly 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Trp Asp Ser Ser Met Asp Ser 
                85                  90                  95      


Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105             


<210>  124
<211>  324
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  NOV2108 DNA VL

<400>  124
agctacgagc tgactcagcc cctgagcgtc agcgtggccc tgggtcagac cgctagaatc       60

acctgtagcg gcgataatat ccctcagcac tcagtgcact ggtatcagca gaagcccggt      120

caggcccccg tgctggtgat ctacgacgac accgagcggc ctagcggaat ccccgagcgg      180

tttagcggct ctaatagcgg taacaccgct accctgacta tctctagggc tcaggccggc      240

gacgaggccg actactactg ctctagctgg gatagctcta tggatagcgt ggtgttcggc      300

ggaggcacta agctgaccgt gctg                                             324


<210>  125
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NOV2108 Light Chain

<400>  125

Ser Tyr Glu Leu Thr Gln Pro Leu Ser Val Ser Val Ala Leu Gly Gln 
1               5                   10                  15      


Thr Ala Arg Ile Thr Cys Ser Gly Asp Asn Ile Pro Gln His Ser Val 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr 
        35                  40                  45              


Asp Asp Thr Glu Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  


Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Arg Ala Gln Ala Gly 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Trp Asp Ser Ser Met Asp Ser 
                85                  90                  95      


Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln Pro Lys 
            100                 105                 110         


Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu Leu Gln 
        115                 120                 125             


Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr Pro Gly 
    130                 135                 140                 


Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys Ala Gly 
145                 150                 155                 160 


Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr Ala Ala 
                165                 170                 175     


Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His Arg Ser 
            180                 185                 190         


Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys Thr Val 
        195                 200                 205             


Ala Pro Thr Glu Cys Ser 
    210                 


<210>  126
<211>  642
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  NOV2108 DNA Light Chain

<400>  126
agctacgagc tgactcagcc cctgagcgtc agcgtggccc tgggtcagac cgctagaatc       60

acctgtagcg gcgataatat ccctcagcac tcagtgcact ggtatcagca gaagcccggt      120

caggcccccg tgctggtgat ctacgacgac accgagcggc ctagcggaat ccccgagcgg      180

tttagcggct ctaatagcgg taacaccgct accctgacta tctctagggc tcaggccggc      240

gacgaggccg actactactg ctctagctgg gatagctcta tggatagcgt ggtgttcggc      300

ggaggcacta agctgaccgt gctgggtcag cctaaggctg cccccagcgt gaccctgttc      360

ccccccagca gcgaggagct gcaggccaac aaggccaccc tggtgtgcct gatcagcgac      420

ttctacccag gcgccgtgac cgtggcctgg aaggccgaca gcagccccgt gaaggccggc      480

gtggagacca ccacccccag caagcagagc aacaacaagt acgccgccag cagctacctg      540

agcctgaccc ccgagcagtg gaagagccac aggtcctaca gctgccaggt gacccacgag      600

ggcagcaccg tggaaaagac cgtggcccca accgagtgca gc                         642


<210>  127
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NOV2109 HCDR1 (Kabat)

<400>  127

Asp Tyr Ala Ile Ser 
1               5   


<210>  128
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NOV2109 HCDR2 (Kabat)

<400>  128

Gly Ile Ile Pro Ala Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  129
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NOV2109 HCDR3 (Kabat)

<400>  129

Glu Gln Asp Pro Glu Tyr Gly Phe Gly Gly Tyr Pro Tyr Glu Ala Met 
1               5                   10                  15      


Asp Val 
        


<210>  130
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NOV2109 VH

<400>  130

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Arg Asp Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Ala Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Gln Asp Pro Glu Tyr Gly Phe Gly Gly Tyr Pro Tyr Glu 
            100                 105                 110         


Ala Met Asp Val Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125         


<210>  131
<211>  381
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  NOV2109 DNA VH

<400>  131
caggtgcagc tggtgcagtc aggcgccgaa gtgaagaaac ccggctctag cgtgaaagtc       60

agctgtaaag ctagtggcgg cacctttaga gactacgcta ttagctgggt cagacaggcc      120

ccaggtcagg gcctggagtg gatgggcgga attatccccg ccttcggcac cgctaactac      180

gctcagaaat ttcagggtag agtgactatc accgccgacg agtctactag caccgcctat      240

atggaactgt ctagcctgag atcagaggac accgccgtct actactgcgc tagagagcag      300

gaccccgagt acggcttcgg cggctacccc tacgaggcta tggacgtgtg gggtcagggc      360

accctggtca ccgtgtctag c                                                381


<210>  132
<211>  457
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NOV2109 Heavy Chain

<400>  132

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Arg Asp Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Ala Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Gln Asp Pro Glu Tyr Gly Phe Gly Gly Tyr Pro Tyr Glu 
            100                 105                 110         


Ala Met Asp Val Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala 
        115                 120                 125             


Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser 
    130                 135                 140                 


Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe 
145                 150                 155                 160 


Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly 
                165                 170                 175     


Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu 
            180                 185                 190         


Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr 
        195                 200                 205             


Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg 
    210                 215                 220                 


Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
225                 230                 235                 240 


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
                245                 250                 255     


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            260                 265                 270         


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
        275                 280                 285             


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    290                 295                 300                 


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
305                 310                 315                 320 


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                325                 330                 335     


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
            340                 345                 350         


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met 
        355                 360                 365             


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
    370                 375                 380                 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
385                 390                 395                 400 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
                405                 410                 415     


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
            420                 425                 430         


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
        435                 440                 445             


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    450                 455         


<210>  133
<211>  1371
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  NOV2109 DNA Heavy Chain

<400>  133
caggtgcagc tggtgcagtc aggcgccgaa gtgaagaaac ccggctctag cgtgaaagtc       60

agctgtaaag ctagtggcgg cacctttaga gactacgcta ttagctgggt cagacaggcc      120

ccaggtcagg gcctggagtg gatgggcgga attatccccg ccttcggcac cgctaactac      180

gctcagaaat ttcagggtag agtgactatc accgccgacg agtctactag caccgcctat      240

atggaactgt ctagcctgag atcagaggac accgccgtct actactgcgc tagagagcag      300

gaccccgagt acggcttcgg cggctacccc tacgaggcta tggacgtgtg gggtcagggc      360

accctggtca ccgtgtctag cgctagcact aagggcccaa gtgtgtttcc cctggccccc      420

agcagcaagt ctacttccgg cggaactgct gccctgggtt gcctggtgaa ggactacttc      480

cccgagcccg tgacagtgtc ctggaactct ggggctctga cttccggcgt gcacaccttc      540

cccgccgtgc tgcagagcag cggcctgtac agcctgagca gcgtggtgac agtgccctcc      600

agctctctgg gaacccagac ctatatctgc aacgtgaacc acaagcccag caacaccaag      660

gtggacaaga gagtggagcc caagagctgc gacaagaccc acacctgccc cccctgccca      720

gctccagaac tgctgggagg gccttccgtg ttcctgttcc cccccaagcc caaggacacc      780

ctgatgatca gcaggacccc cgaggtgacc tgcgtggtgg tggacgtgtc ccacgaggac      840

ccagaggtga agttcaactg gtacgtggac ggcgtggagg tgcacaacgc caagaccaag      900

cccagagagg agcagtacaa cagcacctac agggtggtgt ccgtgctgac cgtgctgcac      960

caggactggc tgaacggcaa agaatacaag tgcaaagtct ccaacaaggc cctgccagcc     1020

ccaatcgaaa agacaatcag caaggccaag ggccagccac gggagcccca ggtgtacacc     1080

ctgcccccca gccgggagga gatgaccaag aaccaggtgt ccctgacctg tctggtgaag     1140

ggcttctacc ccagcgatat cgccgtggag tgggagagca acggccagcc cgagaacaac     1200

tacaagacca cccccccagt gctggacagc gacggcagct tcttcctgta cagcaagctg     1260

accgtggaca agtccaggtg gcagcagggc aacgtgttca gctgcagcgt gatgcacgag     1320

gccctgcaca accactacac ccagaagtcc ctgagcctga gccccggcaa g              1371


<210>  134
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NOV2109 LCDR1 (Kabat)

<400>  134

Ser Gly Asp Asn Ile Pro Gln His Ser Val His 
1               5                   10      


<210>  135
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NOV2109 LCDR2 (Kabat)

<400>  135

Asp Asp Thr Glu Arg Pro Ser 
1               5           


<210>  136
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NOV2109 LCDR3 (Kabat)

<400>  136

Ser Ser Trp Asp Ser Ser Met Asp Ser Val Val 
1               5                   10      


<210>  137
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NOV2109 VL

<400>  137

Ser Tyr Glu Leu Thr Gln Pro Leu Ser Val Ser Val Ala Leu Gly Gln 
1               5                   10                  15      


Thr Ala Arg Ile Thr Cys Ser Gly Asp Asn Ile Pro Gln His Ser Val 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr 
        35                  40                  45              


Asp Asp Thr Glu Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  


Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Arg Ala Gln Ala Gly 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Trp Asp Ser Ser Met Asp Ser 
                85                  90                  95      


Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105             


<210>  138
<211>  324
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  NOV2109 DNA VL

<400>  138
agctacgagc tgactcagcc cctgagcgtc agcgtggccc tgggtcagac cgctagaatc       60

acctgtagcg gcgataatat ccctcagcac tcagtgcact ggtatcagca gaagcccggt      120

caggcccccg tgctggtgat ctacgacgac accgagcggc ctagcggaat ccccgagcgg      180

tttagcggct ctaatagcgg taacaccgct accctgacta tctctagggc tcaggccggc      240

gacgaggccg actactactg ctctagctgg gatagctcta tggatagcgt ggtgttcggc      300

ggaggcacta agctgaccgt gctg                                             324


<210>  139
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NOV2109 Light Chain

<400>  139

Ser Tyr Glu Leu Thr Gln Pro Leu Ser Val Ser Val Ala Leu Gly Gln 
1               5                   10                  15      


Thr Ala Arg Ile Thr Cys Ser Gly Asp Asn Ile Pro Gln His Ser Val 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr 
        35                  40                  45              


Asp Asp Thr Glu Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  


Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Arg Ala Gln Ala Gly 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Trp Asp Ser Ser Met Asp Ser 
                85                  90                  95      


Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln Pro Lys 
            100                 105                 110         


Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu Leu Gln 
        115                 120                 125             


Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr Pro Gly 
    130                 135                 140                 


Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys Ala Gly 
145                 150                 155                 160 


Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr Ala Ala 
                165                 170                 175     


Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His Arg Ser 
            180                 185                 190         


Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys Thr Val 
        195                 200                 205             


Ala Pro Thr Glu Cys Ser 
    210                 


<210>  140
<211>  642
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  NOV2109 DNA Light Chain

<400>  140
agctacgagc tgactcagcc cctgagcgtc agcgtggccc tgggtcagac cgctagaatc       60

acctgtagcg gcgataatat ccctcagcac tcagtgcact ggtatcagca gaagcccggt      120

caggcccccg tgctggtgat ctacgacgac accgagcggc ctagcggaat ccccgagcgg      180

tttagcggct ctaatagcgg taacaccgct accctgacta tctctagggc tcaggccggc      240

gacgaggccg actactactg ctctagctgg gatagctcta tggatagcgt ggtgttcggc      300

ggaggcacta agctgaccgt gctgggtcag cctaaggctg cccccagcgt gaccctgttc      360

ccccccagca gcgaggagct gcaggccaac aaggccaccc tggtgtgcct gatcagcgac      420

ttctacccag gcgccgtgac cgtggcctgg aaggccgaca gcagccccgt gaaggccggc      480

gtggagacca ccacccccag caagcagagc aacaacaagt acgccgccag cagctacctg      540

agcctgaccc ccgagcagtg gaagagccac aggtcctaca gctgccaggt gacccacgag      600

ggcagcaccg tggaaaagac cgtggcccca accgagtgca gc                         642


<210>  141
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NOV2110_N297A HCDR1 (Kabat)

<400>  141

Asp Tyr Ala Ile Ser 
1               5   


<210>  142
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NOV2110_N297A HCDR2 (Kabat)

<400>  142

Gly Ile Ile Pro Ala Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  143
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NOV2110_N297A HCDR3 (Kabat)

<400>  143

Glu Gln Asp Pro Glu Tyr Gly Tyr Gly Gly Phe Pro Tyr Glu Ala Met 
1               5                   10                  15      


Asp Val 
        


<210>  144
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NOV211_N297A VH

<400>  144

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Arg Asp Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Ala Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Gln Asp Pro Glu Tyr Gly Tyr Gly Gly Phe Pro Tyr Glu 
            100                 105                 110         


Ala Met Asp Val Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125         


<210>  145
<211>  381
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  NOV2110_N297A DNA VH

<400>  145
caggtgcaat tggtgcagag cggtgccgaa gtgaaaaaac cgggcagcag cgtgaaagtt       60

agctgcaaag catccggagg gacgtttcgt gactacgcta tctcttgggt gcgccaggcc      120

ccgggccagg gcctcgagtg gatgggcggt atcatcccgg ctttcggcac tgcgaactac      180

gcccagaaat ttcagggccg ggtgaccatt accgccgatg aaagcaccag caccgcctat      240

atggaactga gcagcctgcg cagcgaagat acggccgtgt attattgcgc gcgtgaacag      300

gacccggaat acggttacgg tggtttcccg tatgaagcta tggatgtttg gggccaaggc      360

accctggtga ctgttagctc a                                                381


<210>  146
<211>  457
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NOV2110_N297A Heavy Chain

<400>  146

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Arg Asp Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Ala Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Gln Asp Pro Glu Tyr Gly Tyr Gly Gly Phe Pro Tyr Glu 
            100                 105                 110         


Ala Met Asp Val Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala 
        115                 120                 125             


Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser 
    130                 135                 140                 


Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe 
145                 150                 155                 160 


Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly 
                165                 170                 175     


Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu 
            180                 185                 190         


Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr 
        195                 200                 205             


Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg 
    210                 215                 220                 


Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
225                 230                 235                 240 


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
                245                 250                 255     


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            260                 265                 270         


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
        275                 280                 285             


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    290                 295                 300                 


Gln Tyr Ala Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
305                 310                 315                 320 


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                325                 330                 335     


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
            340                 345                 350         


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met 
        355                 360                 365             


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
    370                 375                 380                 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
385                 390                 395                 400 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
                405                 410                 415     


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
            420                 425                 430         


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
        435                 440                 445             


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    450                 455         


<210>  147
<211>  1371
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  NOV2110_N297A DNA Heavy Chain

<400>  147
caggtgcaat tggtgcagag cggtgccgaa gtgaaaaaac cgggcagcag cgtgaaagtt       60

agctgcaaag catccggagg gacgtttcgt gactacgcta tctcttgggt gcgccaggcc      120

ccgggccagg gcctcgagtg gatgggcggt atcatcccgg ctttcggcac tgcgaactac      180

gcccagaaat ttcagggccg ggtgaccatt accgccgatg aaagcaccag caccgcctat      240

atggaactga gcagcctgcg cagcgaagat acggccgtgt attattgcgc gcgtgaacag      300

gacccggaat acggttacgg tggtttcccg tatgaagcta tggatgtttg gggccaaggc      360

accctggtga ctgttagctc agcctccacc aagggtccat cggtcttccc cctggcaccc      420

tcctccaaga gcacctctgg gggcacagcg gccctgggct gcctggtcaa ggactacttc      480

cccgaaccgg tgacggtgtc gtggaactca ggcgccctga ccagcggcgt gcacaccttc      540

ccggctgtcc tacagtcctc aggactctac tccctcagca gcgtggtgac cgtgccctcc      600

agcagcttgg gcacccagac ctacatctgc aacgtgaatc acaagcccag caacaccaag      660

gtggacaaga gagttgagcc caaatcttgt gacaaaactc acacatgccc accgtgccca      720

gcacctgaac tcctgggggg accgtcagtc ttcctcttcc ccccaaaacc caaggacacc      780

ctcatgatct cccggacccc tgaggtcaca tgcgtggtgg tggacgtgag ccacgaagac      840

cctgaggtca agttcaactg gtacgtggac ggcgtggagg tgcataatgc caagacaaag      900

ccgcgggagg agcagtacgc cagcacgtac cgggtggtca gcgtcctcac cgtcctgcac      960

caggactggc tgaatggcaa ggagtacaag tgcaaggtct ccaacaaagc cctcccagcc     1020

cccatcgaga aaaccatctc caaagccaaa gggcagcccc gagaaccaca ggtgtacacc     1080

ctgcccccat cccgggagga gatgaccaag aaccaggtca gcctgacctg cctggtcaaa     1140

ggcttctatc ccagcgacat cgccgtggag tgggagagca atgggcagcc ggagaacaac     1200

tacaagacca cgcctcccgt gctggactcc gacggctcct tcttcctcta cagcaagctc     1260

accgtggaca agagcaggtg gcagcagggg aacgtcttct catgctccgt gatgcatgag     1320

gctctgcaca accactacac gcagaagagc ctctccctgt ctccgggtaa a              1371


<210>  148
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NOV2110_N297A LCDR1 (Kabat)

<400>  148

Ser Gly Asp Asn Ile Pro Gln His Ser Val His 
1               5                   10      


<210>  149
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NOV2110_N297A LCDR2 (Kabat)

<400>  149

Asp Asp Thr Glu Arg Pro Ser 
1               5           


<210>  150
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NOV2110_N297A LCDR3 (Kabat)

<400>  150

Ser Ser Trp Asp Ser Ser Met Asp Ser Val Val 
1               5                   10      


<210>  151
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NOV2110_N297A VL

<400>  151

Ser Tyr Glu Leu Thr Gln Pro Leu Ser Val Ser Val Ala Leu Gly Gln 
1               5                   10                  15      


Thr Ala Arg Ile Thr Cys Ser Gly Asp Asn Ile Pro Gln His Ser Val 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr 
        35                  40                  45              


Asp Asp Thr Glu Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  


Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Arg Ala Gln Ala Gly 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Trp Asp Ser Ser Met Asp Ser 
                85                  90                  95      


Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105             


<210>  152
<211>  324
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  NOV2110_N297A DNA VL

<400>  152
agctacgaac tgacccagcc gctgagcgtg agcgtggccc tgggccagac cgcgaggatt       60

acctgtagcg gcgataacat cccgcagcat tctgttcatt ggtaccagca gaaaccgggc      120

caggcgccgg tgctggtgat ctacgacgac actgaacgtc cgagcggcat cccggaacgt      180

tttagcggat ccaacagcgg caacaccgcg accctgacca ttagcagggc ccaggcgggc      240

gacgaagcgg attattactg ctcttcttgg gactcttcta tggactctgt tgtgtttggc      300

ggcggcacga agttaaccgt ccta                                             324


<210>  153
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NOV2110_N297A Light Chain

<400>  153

Ser Tyr Glu Leu Thr Gln Pro Leu Ser Val Ser Val Ala Leu Gly Gln 
1               5                   10                  15      


Thr Ala Arg Ile Thr Cys Ser Gly Asp Asn Ile Pro Gln His Ser Val 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr 
        35                  40                  45              


Asp Asp Thr Glu Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  


Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Arg Ala Gln Ala Gly 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Trp Asp Ser Ser Met Asp Ser 
                85                  90                  95      


Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln Pro Lys 
            100                 105                 110         


Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu Leu Gln 
        115                 120                 125             


Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr Pro Gly 
    130                 135                 140                 


Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys Ala Gly 
145                 150                 155                 160 


Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr Ala Ala 
                165                 170                 175     


Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His Arg Ser 
            180                 185                 190         


Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys Thr Val 
        195                 200                 205             


Ala Pro Thr Glu Cys Ser 
    210                 


<210>  154
<211>  642
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  NOV2110_N297A DNA Light Chain

<400>  154
agctacgaac tgacccagcc gctgagcgtg agcgtggccc tgggccagac cgcgaggatt       60

acctgtagcg gcgataacat cccgcagcat tctgttcatt ggtaccagca gaaaccgggc      120

caggcgccgg tgctggtgat ctacgacgac actgaacgtc cgagcggcat cccggaacgt      180

tttagcggat ccaacagcgg caacaccgcg accctgacca ttagcagggc ccaggcgggc      240

gacgaagcgg attattactg ctcttcttgg gactcttcta tggactctgt tgtgtttggc      300

ggcggcacga agttaaccgt cctaggtcag cccaaggctg ccccctcggt cactctgttc      360

ccgccctcct ctgaggagct tcaagccaac aaggccacac tggtgtgtct cataagtgac      420

ttctacccgg gagccgtgac agtggcctgg aaggcagata gcagccccgt caaggcggga      480

gtggagacca ccacaccctc caaacaaagc aacaacaagt acgcggccag cagctatctg      540

agcctgacgc ctgagcagtg gaagtcccac agaagctaca gctgccaggt cacgcatgaa      600

gggagcaccg tggagaagac agtggcccct acagaatgtt ca                         642


<210>  155
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NOV2111_N297A HCDR1 (Kabat)

<400>  155

Asp Tyr Ala Ile Ser 
1               5   


<210>  156
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NOV2111_N297A HCDR2 (Kabat)

<400>  156

Gly Ile Ile Pro Ala Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  157
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NOV2111_N297A HCDR3 (Kabat)

<400>  157

Glu Gln Asp Pro Glu Tyr Gly Tyr Gly Gly Tyr Pro Phe Glu Ala Met 
1               5                   10                  15      


Asp Val 
        


<210>  158
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NOV2111_N297A VH

<400>  158

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Arg Asp Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Ala Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Gln Asp Pro Glu Tyr Gly Tyr Gly Gly Tyr Pro Phe Glu 
            100                 105                 110         


Ala Met Asp Val Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125         


<210>  159
<211>  381
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  NOV2111_N297A DNA VH

<400>  159
caggtgcaat tggtgcagag cggtgccgaa gtgaaaaaac cgggcagcag cgtgaaagtt       60

agctgcaaag catccggagg gacgtttcgt gactacgcta tctcttgggt gcgccaggcc      120

ccgggccagg gcctcgagtg gatgggcggt atcatcccgg ctttcggcac tgcgaactac      180

gcccagaaat ttcagggccg ggtgaccatt accgccgatg aaagcaccag caccgcctat      240

atggaactga gcagcctgcg cagcgaagat acggccgtgt attattgcgc gcgtgaacag      300

gacccggaat acggttacgg tggttacccg ttcgaagcta tggatgtttg gggccaaggc      360

accctggtga ctgttagctc a                                                381


<210>  160
<211>  457
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NOV2111_N297A Heavy Chain

<400>  160

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Arg Asp Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Ala Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Gln Asp Pro Glu Tyr Gly Tyr Gly Gly Tyr Pro Phe Glu 
            100                 105                 110         


Ala Met Asp Val Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala 
        115                 120                 125             


Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser 
    130                 135                 140                 


Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe 
145                 150                 155                 160 


Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly 
                165                 170                 175     


Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu 
            180                 185                 190         


Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr 
        195                 200                 205             


Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg 
    210                 215                 220                 


Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
225                 230                 235                 240 


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
                245                 250                 255     


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            260                 265                 270         


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
        275                 280                 285             


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    290                 295                 300                 


Gln Tyr Ala Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
305                 310                 315                 320 


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                325                 330                 335     


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
            340                 345                 350         


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met 
        355                 360                 365             


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
    370                 375                 380                 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
385                 390                 395                 400 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
                405                 410                 415     


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
            420                 425                 430         


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
        435                 440                 445             


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    450                 455         


<210>  161
<211>  1371
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  NOV2111_N297A DNA Heavy Chain

<400>  161
caggtgcaat tggtgcagag cggtgccgaa gtgaaaaaac cgggcagcag cgtgaaagtt       60

agctgcaaag catccggagg gacgtttcgt gactacgcta tctcttgggt gcgccaggcc      120

ccgggccagg gcctcgagtg gatgggcggt atcatcccgg ctttcggcac tgcgaactac      180

gcccagaaat ttcagggccg ggtgaccatt accgccgatg aaagcaccag caccgcctat      240

atggaactga gcagcctgcg cagcgaagat acggccgtgt attattgcgc gcgtgaacag      300

gacccggaat acggttacgg tggttacccg ttcgaagcta tggatgtttg gggccaaggc      360

accctggtga ctgttagctc agcctccacc aagggtccat cggtcttccc cctggcaccc      420

tcctccaaga gcacctctgg gggcacagcg gccctgggct gcctggtcaa ggactacttc      480

cccgaaccgg tgacggtgtc gtggaactca ggcgccctga ccagcggcgt gcacaccttc      540

ccggctgtcc tacagtcctc aggactctac tccctcagca gcgtggtgac cgtgccctcc      600

agcagcttgg gcacccagac ctacatctgc aacgtgaatc acaagcccag caacaccaag      660

gtggacaaga gagttgagcc caaatcttgt gacaaaactc acacatgccc accgtgccca      720

gcacctgaac tcctgggggg accgtcagtc ttcctcttcc ccccaaaacc caaggacacc      780

ctcatgatct cccggacccc tgaggtcaca tgcgtggtgg tggacgtgag ccacgaagac      840

cctgaggtca agttcaactg gtacgtggac ggcgtggagg tgcataatgc caagacaaag      900

ccgcgggagg agcagtacgc cagcacgtac cgggtggtca gcgtcctcac cgtcctgcac      960

caggactggc tgaatggcaa ggagtacaag tgcaaggtct ccaacaaagc cctcccagcc     1020

cccatcgaga aaaccatctc caaagccaaa gggcagcccc gagaaccaca ggtgtacacc     1080

ctgcccccat cccgggagga gatgaccaag aaccaggtca gcctgacctg cctggtcaaa     1140

ggcttctatc ccagcgacat cgccgtggag tgggagagca atgggcagcc ggagaacaac     1200

tacaagacca cgcctcccgt gctggactcc gacggctcct tcttcctcta cagcaagctc     1260

accgtggaca agagcaggtg gcagcagggg aacgtcttct catgctccgt gatgcatgag     1320

gctctgcaca accactacac gcagaagagc ctctccctgt ctccgggtaa a              1371


<210>  162
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NOV2111_N297A LCDR1 (Kabat)

<400>  162

Ser Gly Asp Asn Ile Pro Gln His Ser Val His 
1               5                   10      


<210>  163
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NOV2111_N297A LCDR2 (Kabat)

<400>  163

Asp Asp Thr Glu Arg Pro Ser 
1               5           


<210>  164
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NOV2111_N297A LCDR3 (Kabat)

<400>  164

Ser Ser Trp Asp Ser Ser Met Asp Ser Val Val 
1               5                   10      


<210>  165
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NOV2111_N297A VL

<400>  165

Ser Tyr Glu Leu Thr Gln Pro Leu Ser Val Ser Val Ala Leu Gly Gln 
1               5                   10                  15      


Thr Ala Arg Ile Thr Cys Ser Gly Asp Asn Ile Pro Gln His Ser Val 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr 
        35                  40                  45              


Asp Asp Thr Glu Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  


Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Arg Ala Gln Ala Gly 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Trp Asp Ser Ser Met Asp Ser 
                85                  90                  95      


Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105             


<210>  166
<211>  324
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  NOV2111_N297A DNA VL

<400>  166
agctacgaac tgacccagcc gctgagcgtg agcgtggccc tgggccagac cgcgaggatt       60

acctgtagcg gcgataacat cccgcagcat tctgttcatt ggtaccagca gaaaccgggc      120

caggcgccgg tgctggtgat ctacgacgac actgaacgtc cgagcggcat cccggaacgt      180

tttagcggat ccaacagcgg caacaccgcg accctgacca ttagcagggc ccaggcgggc      240

gacgaagcgg attattactg ctcttcttgg gactcttcta tggactctgt tgtgtttggc      300

ggcggcacga agttaaccgt ccta                                             324


<210>  167
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NOV2111_N297A Light Chain

<400>  167

Ser Tyr Glu Leu Thr Gln Pro Leu Ser Val Ser Val Ala Leu Gly Gln 
1               5                   10                  15      


Thr Ala Arg Ile Thr Cys Ser Gly Asp Asn Ile Pro Gln His Ser Val 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr 
        35                  40                  45              


Asp Asp Thr Glu Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  


Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Arg Ala Gln Ala Gly 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Trp Asp Ser Ser Met Asp Ser 
                85                  90                  95      


Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln Pro Lys 
            100                 105                 110         


Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu Leu Gln 
        115                 120                 125             


Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr Pro Gly 
    130                 135                 140                 


Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys Ala Gly 
145                 150                 155                 160 


Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr Ala Ala 
                165                 170                 175     


Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His Arg Ser 
            180                 185                 190         


Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys Thr Val 
        195                 200                 205             


Ala Pro Thr Glu Cys Ser 
    210                 


<210>  168
<211>  642
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  NOV2111_N297A DNA Light Chain

<400>  168
agctacgaac tgacccagcc gctgagcgtg agcgtggccc tgggccagac cgcgaggatt       60

acctgtagcg gcgataacat cccgcagcat tctgttcatt ggtaccagca gaaaccgggc      120

caggcgccgg tgctggtgat ctacgacgac actgaacgtc cgagcggcat cccggaacgt      180

tttagcggat ccaacagcgg caacaccgcg accctgacca ttagcagggc ccaggcgggc      240

gacgaagcgg attattactg ctcttcttgg gactcttcta tggactctgt tgtgtttggc      300

ggcggcacga agttaaccgt cctaggtcag cccaaggctg ccccctcggt cactctgttc      360

ccgccctcct ctgaggagct tcaagccaac aaggccacac tggtgtgtct cataagtgac      420

ttctacccgg gagccgtgac agtggcctgg aaggcagata gcagccccgt caaggcggga      480

gtggagacca ccacaccctc caaacaaagc aacaacaagt acgcggccag cagctatctg      540

agcctgacgc ctgagcagtg gaagtcccac agaagctaca gctgccaggt cacgcatgaa      600

gggagcaccg tggagaagac agtggcccct acagaatgtt ca                         642


<210>  169
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NOV2112 HCDR1 (Kabat)

<400>  169

Asp Tyr Ala Ile Ser 
1               5   


<210>  170
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NOV2112 HCDR2 (Kabat)

<400>  170

Gly Ile Ile Pro Ala Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  171
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NOV2112 HCDR3 (Kabat)

<400>  171

Glu Gln Asp Pro Ser Tyr Gly Tyr Gly Gly Tyr Pro Tyr Glu Ala Met 
1               5                   10                  15      


Asp Val 
        


<210>  172
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NOV2112 VH

<400>  172

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Arg Asp Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Ala Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Gln Asp Pro Ser Tyr Gly Tyr Gly Gly Tyr Pro Tyr Glu 
            100                 105                 110         


Ala Met Asp Val Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125         


<210>  173
<211>  381
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  NOV2112 DNA VH

<400>  173
caggtgcagc tggtgcagtc aggcgccgaa gtgaagaaac ccggctctag cgtgaaagtc       60

agctgtaaag ctagtggcgg cacctttaga gactacgcta ttagctgggt cagacaggcc      120

ccaggtcagg gcctggagtg gatgggcgga attatccccg ccttcggcac cgctaactac      180

gctcagaaat ttcagggtag agtgactatc accgccgacg agtctactag caccgcctat      240

atggaactgt ctagcctgag atcagaggac accgccgtct actactgcgc tagagagcag      300

gacccctcct acggctacgg cggctacccc tacgaggcta tggacgtgtg gggtcagggc      360

accctggtca ccgtgtctag c                                                381


<210>  174
<211>  457
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NOV2112 Heavy Chain

<400>  174

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Arg Asp Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Ala Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Gln Asp Pro Ser Tyr Gly Tyr Gly Gly Tyr Pro Tyr Glu 
            100                 105                 110         


Ala Met Asp Val Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala 
        115                 120                 125             


Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser 
    130                 135                 140                 


Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe 
145                 150                 155                 160 


Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly 
                165                 170                 175     


Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu 
            180                 185                 190         


Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr 
        195                 200                 205             


Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg 
    210                 215                 220                 


Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
225                 230                 235                 240 


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
                245                 250                 255     


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            260                 265                 270         


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
        275                 280                 285             


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    290                 295                 300                 


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
305                 310                 315                 320 


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                325                 330                 335     


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
            340                 345                 350         


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met 
        355                 360                 365             


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
    370                 375                 380                 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
385                 390                 395                 400 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
                405                 410                 415     


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
            420                 425                 430         


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
        435                 440                 445             


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    450                 455         


<210>  175
<211>  1371
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  NOV2112 DNA Heavy Chain

<400>  175
caggtgcagc tggtgcagtc aggcgccgaa gtgaagaaac ccggctctag cgtgaaagtc       60

agctgtaaag ctagtggcgg cacctttaga gactacgcta ttagctgggt cagacaggcc      120

ccaggtcagg gcctggagtg gatgggcgga attatccccg ccttcggcac cgctaactac      180

gctcagaaat ttcagggtag agtgactatc accgccgacg agtctactag caccgcctat      240

atggaactgt ctagcctgag atcagaggac accgccgtct actactgcgc tagagagcag      300

gacccctcct acggctacgg cggctacccc tacgaggcta tggacgtgtg gggtcagggc      360

accctggtca ccgtgtctag cgctagcact aagggcccaa gtgtgtttcc cctggccccc      420

agcagcaagt ctacttccgg cggaactgct gccctgggtt gcctggtgaa ggactacttc      480

cccgagcccg tgacagtgtc ctggaactct ggggctctga cttccggcgt gcacaccttc      540

cccgccgtgc tgcagagcag cggcctgtac agcctgagca gcgtggtgac agtgccctcc      600

agctctctgg gaacccagac ctatatctgc aacgtgaacc acaagcccag caacaccaag      660

gtggacaaga gagtggagcc caagagctgc gacaagaccc acacctgccc cccctgccca      720

gctccagaac tgctgggagg gccttccgtg ttcctgttcc cccccaagcc caaggacacc      780

ctgatgatca gcaggacccc cgaggtgacc tgcgtggtgg tggacgtgtc ccacgaggac      840

ccagaggtga agttcaactg gtacgtggac ggcgtggagg tgcacaacgc caagaccaag      900

cccagagagg agcagtacaa cagcacctac agggtggtgt ccgtgctgac cgtgctgcac      960

caggactggc tgaacggcaa agaatacaag tgcaaagtct ccaacaaggc cctgccagcc     1020

ccaatcgaaa agacaatcag caaggccaag ggccagccac gggagcccca ggtgtacacc     1080

ctgcccccca gccgggagga gatgaccaag aaccaggtgt ccctgacctg tctggtgaag     1140

ggcttctacc ccagcgatat cgccgtggag tgggagagca acggccagcc cgagaacaac     1200

tacaagacca cccccccagt gctggacagc gacggcagct tcttcctgta cagcaagctg     1260

accgtggaca agtccaggtg gcagcagggc aacgtgttca gctgcagcgt gatgcacgag     1320

gccctgcaca accactacac ccagaagtcc ctgagcctga gccccggcaa g              1371


<210>  176
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NOV2112 LCDR1 (Kabat)

<400>  176

Ser Gly Asp Asn Ile Pro Gln His Ser Val His 
1               5                   10      


<210>  177
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NOV2112 LCDR2 (Kabat)

<400>  177

Asp Asp Thr Glu Arg Pro Ser 
1               5           


<210>  178
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NOV2112 LCDR3 (Kabat)

<400>  178

Ser Ser Trp Asp Ser Ser Met Asp Ser Val Val 
1               5                   10      


<210>  179
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NOV2112 VL

<400>  179

Ser Tyr Glu Leu Thr Gln Pro Leu Ser Val Ser Val Ala Leu Gly Gln 
1               5                   10                  15      


Thr Ala Arg Ile Thr Cys Ser Gly Asp Asn Ile Pro Gln His Ser Val 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr 
        35                  40                  45              


Asp Asp Thr Glu Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  


Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Arg Ala Gln Ala Gly 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Trp Asp Ser Ser Met Asp Ser 
                85                  90                  95      


Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105             


<210>  180
<211>  324
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  NOV2112 DNA VL

<400>  180
agctacgagc tgactcagcc cctgagcgtc agcgtggccc tgggtcagac cgctagaatc       60

acctgtagcg gcgataatat ccctcagcac tcagtgcact ggtatcagca gaagcccggt      120

caggcccccg tgctggtgat ctacgacgac accgagcggc ctagcggaat ccccgagcgg      180

tttagcggct ctaatagcgg taacaccgct accctgacta tctctagggc tcaggccggc      240

gacgaggccg actactactg ctctagctgg gatagctcta tggatagcgt ggtgttcggc      300

ggaggcacta agctgaccgt gctg                                             324


<210>  181
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NOV2112 Light Chain

<400>  181

Ser Tyr Glu Leu Thr Gln Pro Leu Ser Val Ser Val Ala Leu Gly Gln 
1               5                   10                  15      


Thr Ala Arg Ile Thr Cys Ser Gly Asp Asn Ile Pro Gln His Ser Val 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr 
        35                  40                  45              


Asp Asp Thr Glu Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  


Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Arg Ala Gln Ala Gly 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Trp Asp Ser Ser Met Asp Ser 
                85                  90                  95      


Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln Pro Lys 
            100                 105                 110         


Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu Leu Gln 
        115                 120                 125             


Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr Pro Gly 
    130                 135                 140                 


Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys Ala Gly 
145                 150                 155                 160 


Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr Ala Ala 
                165                 170                 175     


Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His Arg Ser 
            180                 185                 190         


Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys Thr Val 
        195                 200                 205             


Ala Pro Thr Glu Cys Ser 
    210                 


<210>  182
<211>  642
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  NOV2112 DNA Light Chain

<400>  182
agctacgagc tgactcagcc cctgagcgtc agcgtggccc tgggtcagac cgctagaatc       60

acctgtagcg gcgataatat ccctcagcac tcagtgcact ggtatcagca gaagcccggt      120

caggcccccg tgctggtgat ctacgacgac accgagcggc ctagcggaat ccccgagcgg      180

tttagcggct ctaatagcgg taacaccgct accctgacta tctctagggc tcaggccggc      240

gacgaggccg actactactg ctctagctgg gatagctcta tggatagcgt ggtgttcggc      300

ggaggcacta agctgaccgt gctgggtcag cctaaggctg cccccagcgt gaccctgttc      360

ccccccagca gcgaggagct gcaggccaac aaggccaccc tggtgtgcct gatcagcgac      420

ttctacccag gcgccgtgac cgtggcctgg aaggccgaca gcagccccgt gaaggccggc      480

gtggagacca ccacccccag caagcagagc aacaacaagt acgccgccag cagctacctg      540

agcctgaccc ccgagcagtg gaagagccac aggtcctaca gctgccaggt gacccacgag      600

ggcagcaccg tggaaaagac cgtggcccca accgagtgca gc                         642


<210>  183
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NOV2113 HCDR1 (Kabat)

<400>  183

Asp Tyr Ala Ile Ser 
1               5   


<210>  184
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NOV2113 HCDR2 (Kabat)

<400>  184

Gly Ile Ile Pro Ala Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  185
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NOV2113 HCDR3 (Kabat)

<400>  185

Glu Gln Ser Pro Glu Tyr Gly Tyr Gly Gly Tyr Pro Tyr Glu Ala Met 
1               5                   10                  15      


Asp Val 
        


<210>  186
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NOV2113 VH

<400>  186

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Arg Asp Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Ala Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Gln Ser Pro Glu Tyr Gly Tyr Gly Gly Tyr Pro Tyr Glu 
            100                 105                 110         


Ala Met Asp Val Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125         


<210>  187
<211>  381
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  NOV2113 DNA VH

<400>  187
caggtgcagc tggtgcagtc aggcgccgaa gtgaagaaac ccggctctag cgtgaaagtc       60

agctgtaaag ctagtggcgg cacctttaga gactacgcta ttagctgggt cagacaggcc      120

ccaggtcagg gcctggagtg gatgggcgga attatccccg ccttcggcac cgctaactac      180

gctcagaaat ttcagggtag agtgactatc accgccgacg agtctactag caccgcctat      240

atggaactgt ctagcctgag atcagaggac accgccgtct actactgcgc tagagagcag      300

tcccccgagt acggctacgg cggctacccc tacgaggcta tggacgtgtg gggtcagggc      360

accctggtca ccgtgtctag c                                                381


<210>  188
<211>  457
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NOV2113 Heavy Chain

<400>  188

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Arg Asp Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Ala Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Gln Ser Pro Glu Tyr Gly Tyr Gly Gly Tyr Pro Tyr Glu 
            100                 105                 110         


Ala Met Asp Val Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala 
        115                 120                 125             


Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser 
    130                 135                 140                 


Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe 
145                 150                 155                 160 


Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly 
                165                 170                 175     


Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu 
            180                 185                 190         


Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr 
        195                 200                 205             


Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg 
    210                 215                 220                 


Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
225                 230                 235                 240 


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
                245                 250                 255     


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            260                 265                 270         


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
        275                 280                 285             


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    290                 295                 300                 


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
305                 310                 315                 320 


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                325                 330                 335     


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
            340                 345                 350         


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met 
        355                 360                 365             


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
    370                 375                 380                 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
385                 390                 395                 400 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
                405                 410                 415     


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
            420                 425                 430         


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
        435                 440                 445             


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    450                 455         


<210>  189
<211>  1371
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  NOV2113 DNA Heavy Chain

<400>  189
caggtgcagc tggtgcagtc aggcgccgaa gtgaagaaac ccggctctag cgtgaaagtc       60

agctgtaaag ctagtggcgg cacctttaga gactacgcta ttagctgggt cagacaggcc      120

ccaggtcagg gcctggagtg gatgggcgga attatccccg ccttcggcac cgctaactac      180

gctcagaaat ttcagggtag agtgactatc accgccgacg agtctactag caccgcctat      240

atggaactgt ctagcctgag atcagaggac accgccgtct actactgcgc tagagagcag      300

tcccccgagt acggctacgg cggctacccc tacgaggcta tggacgtgtg gggtcagggc      360

accctggtca ccgtgtctag cgctagcact aagggcccaa gtgtgtttcc cctggccccc      420

agcagcaagt ctacttccgg cggaactgct gccctgggtt gcctggtgaa ggactacttc      480

cccgagcccg tgacagtgtc ctggaactct ggggctctga cttccggcgt gcacaccttc      540

cccgccgtgc tgcagagcag cggcctgtac agcctgagca gcgtggtgac agtgccctcc      600

agctctctgg gaacccagac ctatatctgc aacgtgaacc acaagcccag caacaccaag      660

gtggacaaga gagtggagcc caagagctgc gacaagaccc acacctgccc cccctgccca      720

gctccagaac tgctgggagg gccttccgtg ttcctgttcc cccccaagcc caaggacacc      780

ctgatgatca gcaggacccc cgaggtgacc tgcgtggtgg tggacgtgtc ccacgaggac      840

ccagaggtga agttcaactg gtacgtggac ggcgtggagg tgcacaacgc caagaccaag      900

cccagagagg agcagtacaa cagcacctac agggtggtgt ccgtgctgac cgtgctgcac      960

caggactggc tgaacggcaa agaatacaag tgcaaagtct ccaacaaggc cctgccagcc     1020

ccaatcgaaa agacaatcag caaggccaag ggccagccac gggagcccca ggtgtacacc     1080

ctgcccccca gccgggagga gatgaccaag aaccaggtgt ccctgacctg tctggtgaag     1140

ggcttctacc ccagcgatat cgccgtggag tgggagagca acggccagcc cgagaacaac     1200

tacaagacca cccccccagt gctggacagc gacggcagct tcttcctgta cagcaagctg     1260

accgtggaca agtccaggtg gcagcagggc aacgtgttca gctgcagcgt gatgcacgag     1320

gccctgcaca accactacac ccagaagtcc ctgagcctga gccccggcaa g              1371


<210>  190
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NOV2113 LCDR1 (Kabat)

<400>  190

Ser Gly Asp Asn Ile Pro Gln His Ser Val His 
1               5                   10      


<210>  191
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NOV2113 LCDR2 (Kabat)

<400>  191

Asp Asp Thr Glu Arg Pro Ser 
1               5           


<210>  192
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NOV2113 LCDR3 (Kabat)

<400>  192

Ser Ser Trp Asp Ser Ser Met Asp Ser Val Val 
1               5                   10      


<210>  193
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NOV2113 VL

<400>  193

Ser Tyr Glu Leu Thr Gln Pro Leu Ser Val Ser Val Ala Leu Gly Gln 
1               5                   10                  15      


Thr Ala Arg Ile Thr Cys Ser Gly Asp Asn Ile Pro Gln His Ser Val 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr 
        35                  40                  45              


Asp Asp Thr Glu Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  


Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Arg Ala Gln Ala Gly 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Trp Asp Ser Ser Met Asp Ser 
                85                  90                  95      


Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105             


<210>  194
<211>  324
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  NOV2113 DNA VL

<400>  194
agctacgagc tgactcagcc cctgagcgtc agcgtggccc tgggtcagac cgctagaatc       60

acctgtagcg gcgataatat ccctcagcac tcagtgcact ggtatcagca gaagcccggt      120

caggcccccg tgctggtgat ctacgacgac accgagcggc ctagcggaat ccccgagcgg      180

tttagcggct ctaatagcgg taacaccgct accctgacta tctctagggc tcaggccggc      240

gacgaggccg actactactg ctctagctgg gatagctcta tggatagcgt ggtgttcggc      300

ggaggcacta agctgaccgt gctg                                             324


<210>  195
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NOV2113 Light Chain

<400>  195

Ser Tyr Glu Leu Thr Gln Pro Leu Ser Val Ser Val Ala Leu Gly Gln 
1               5                   10                  15      


Thr Ala Arg Ile Thr Cys Ser Gly Asp Asn Ile Pro Gln His Ser Val 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr 
        35                  40                  45              


Asp Asp Thr Glu Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  


Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Arg Ala Gln Ala Gly 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Trp Asp Ser Ser Met Asp Ser 
                85                  90                  95      


Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln Pro Lys 
            100                 105                 110         


Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu Leu Gln 
        115                 120                 125             


Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr Pro Gly 
    130                 135                 140                 


Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys Ala Gly 
145                 150                 155                 160 


Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr Ala Ala 
                165                 170                 175     


Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His Arg Ser 
            180                 185                 190         


Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys Thr Val 
        195                 200                 205             


Ala Pro Thr Glu Cys Ser 
    210                 


<210>  196
<211>  642
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  NOV2113 DNA Light Chain

<400>  196
agctacgagc tgactcagcc cctgagcgtc agcgtggccc tgggtcagac cgctagaatc       60

acctgtagcg gcgataatat ccctcagcac tcagtgcact ggtatcagca gaagcccggt      120

caggcccccg tgctggtgat ctacgacgac accgagcggc ctagcggaat ccccgagcgg      180

tttagcggct ctaatagcgg taacaccgct accctgacta tctctagggc tcaggccggc      240

gacgaggccg actactactg ctctagctgg gatagctcta tggatagcgt ggtgttcggc      300

ggaggcacta agctgaccgt gctgggtcag cctaaggctg cccccagcgt gaccctgttc      360

ccccccagca gcgaggagct gcaggccaac aaggccaccc tggtgtgcct gatcagcgac      420

ttctacccag gcgccgtgac cgtggcctgg aaggccgaca gcagccccgt gaaggccggc      480

gtggagacca ccacccccag caagcagagc aacaacaagt acgccgccag cagctacctg      540

agcctgaccc ccgagcagtg gaagagccac aggtcctaca gctgccaggt gacccacgag      600

ggcagcaccg tggaaaagac cgtggcccca accgagtgca gc                         642


<210>  197
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2B6 HCDR1 (Kabat)

<400>  197

Asp Tyr Pro Phe Thr Asn Tyr Trp Ile His 
1               5                   10  


<210>  198
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2B6 HCDR2 (Kabat)

<400>  198

Val Ile Asp Pro Ser Asp Thr Tyr Pro Asn Tyr Asn Lys Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  199
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2B6 HCDR3 (Kabat)

<400>  199

Asn Gly Asp Ser Asp Tyr Tyr Ser Gly Met Asp Tyr 
1               5                   10          


<210>  200
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2B6 VH

<400>  200

Gln Val Gln Leu Gln Gln Pro Val Thr Glu Leu Val Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Met Leu Ser Cys Lys Ala Ser Asp Tyr Pro Phe Thr Asn Tyr 
            20                  25                  30          


Trp Ile His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Val Ile Asp Pro Ser Asp Thr Tyr Pro Asn Tyr Asn Lys Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Val Val Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Asp Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asn Gly Asp Ser Asp Tyr Tyr Ser Gly Met Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Ser Val Thr Val Ser Ser 
        115                 120     


<210>  201
<211>  363
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  2B6 DNA VH

<400>  201
caggtccaat tgcagcagcc tgtgactgag ctggtgaggc cgggggcttc agtgatgttg       60

tcctgcaagg cttctgacta ccccttcacc aactactgga tacactgggt aaagcagagg      120

cctggacaag gcctggagtg gatcggagtg attgatcctt ctgatactta tccaaattac      180

aataaaaagt tcaagggcaa ggccacattg actgtagtcg tatcctccag cacagcctac      240

atgcagctca gcagcctgac atctgacgat tctgcggtct attactgtgc aagaaacggt      300

gattccgatt attactctgg tatggactac tggggtcaag gaacctcagt caccgtctcc      360

tca                                                                    363


<210>  202
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2B6 LCDR1 (Kabat)

<400>  202

Arg Thr Ser Gln Ser Ile Gly Thr Asn Ile His 
1               5                   10      


<210>  203
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2B6 LCDR2 (Kabat)

<400>  203

Asn Val Ser Glu Ser Ile Ser 
1               5           


<210>  204
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2B6 LCDR3 (Kabat)

<400>  204

Gln Gln Ser Asn Thr Trp Pro Phe Thr 
1               5                   


<210>  205
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2B6 VL

<400>  205

Asp Ile Leu Leu Thr Gln Ser Pro Ala Ile Leu Ser Val Ser Pro Gly 
1               5                   10                  15      


Glu Arg Val Ser Phe Ser Cys Arg Thr Ser Gln Ser Ile Gly Thr Asn 
            20                  25                  30          


Ile His Trp Tyr Gln Gln Arg Thr Asn Gly Phe Pro Arg Leu Leu Ile 
        35                  40                  45              


Lys Asn Val Ser Glu Ser Ile Ser Gly Ile Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Ile Leu Ser Ile Asn Ser Val Glu Ser 
65                  70                  75                  80  


Glu Asp Ile Ala Asp Tyr Tyr Cys Gln Gln Ser Asn Thr Trp Pro Phe 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  206
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  2B6 DNA VL

<400>  206
gacatcttgc tgactcagtc tccagccatc ctgtctgtga gtccaggaga gagagtcagt       60

ttttcctgca ggaccagtca gagcattggc acaaacatac actggtatca gcaaagaaca      120

aatggttttc caaggcttct cataaagaat gtttctgagt ctatctctgg gatcccttcc      180

aggtttagtg gcagtggatc agggacagat tttattctta gcatcaacag tgtggagtct      240

gaagatattg cagattatta ttgtcaacaa agtaatacct ggccgttcac gttcggaggg      300

gggaccaagc tggaaataaa a                                                321


<210>  207
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab20 HCDR3 (Kabat)

<400>  207

Ser Tyr Gly Ile Ser 
1               5   


<210>  208
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab20 HCDR2 (Kabat)

<400>  208

Trp Ile Ser Ala Tyr Asn Gly Asn Thr Lys Tyr Ala Gln Lys Leu Gln 
1               5                   10                  15      


Gly 
    


<210>  209
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab20 HCDR3 (Kabat)

<400>  209

Asp Ser Ala Ala His Gly Met Asp Val 
1               5                   


<210>  210
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab20 VH

<400>  210

Gln Val Gln Leu Val Gln Ser Gly Gly Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Thr Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Gly Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Ser Ala Tyr Asn Gly Asn Thr Lys Tyr Ala Gln Lys Leu 
    50                  55                  60                  


Gln Gly Arg Leu Thr Met Thr Thr Asp Thr Ser Thr Thr Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Ser Ala Ala His Gly Met Asp Val Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Val Thr Val Ser Ser 
        115             


<210>  211
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab20 LCDR1 (Kabat)

<400>  211

Arg Ala Ser Gln Gly Ile Ser Ser Trp Leu Ala 
1               5                   10      


<210>  212
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab20 LCDR2 (Kabat)

<400>  212

Ala Ala Ser Ser Leu Gln Ser 
1               5           


<210>  213
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab20 LCDR3 (Kabat)

<400>  213

Gln Gln Tyr Asn Ser Tyr Pro Tyr Thr 
1               5                   


<210>  214
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab20 VL

<400>  214

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Glu Lys Ala Pro Lys Ser Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Arg Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Ser Tyr Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105             


<210>  215
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab24 HCDR1 (Kabat)

<400>  215

Ser Tyr Gly Leu Ser 
1               5   


<210>  216
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab24 HCDR2 (Kabat)

<400>  216

Trp Ile Ser Pro Tyr Asn Gly Asn Thr His Tyr Ala Gln Lys Leu Gln 
1               5                   10                  15      


Gly 
    


<210>  217
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab24 HCDR3 (Kabat)

<400>  217

Asp Ser Ala Ala His Gly Met Asp Val 
1               5                   


<210>  218
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab24 VH

<400>  218

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Gly Leu Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Ser Pro Tyr Asn Gly Asn Thr His Tyr Ala Gln Lys Leu 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Thr Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Asp Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Ser Ala Ala His Gly Met Asp Val Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Val Thr Val Ser Ser 
        115             


<210>  219
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab24 LCDR1 (Kabat)

<400>  219

Arg Ala Ser Gln Gly Ile Ser Ser Trp Leu Ala 
1               5                   10      


<210>  220
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab24 LCDR2 (Kabat)

<400>  220

Ala Ala Ser Ser Leu Gln Ser 
1               5           


<210>  221
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab24 LCDR3 (Kabat)

<400>  221

Gln Gln Tyr Asn Ser Tyr Pro Tyr Thr 
1               5                   


<210>  222
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab24 VL

<400>  222

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Glu Lys Ala Pro Lys Ser Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Ser Tyr Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105             


<210>  223
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab26 HCDR1 (Kabat)

<400>  223

Ser Tyr Gly Leu Ser 
1               5   


<210>  224
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab26 HCDR2 (Kabat)

<400>  224

Trp Ile Ser Ala Tyr Asn Gly Asn Thr Asn Tyr Ala Gln Lys Leu Gln 
1               5                   10                  15      


Gly 
    


<210>  225
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab26 HCDR3 (Kabat)

<400>  225

Asp Ser Ala Ala His Gly Met Asp Val 
1               5                   


<210>  226
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab26 VH

<400>  226

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Gly Leu Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Ser Ala Tyr Asn Gly Asn Thr Asn Tyr Ala Gln Lys Leu 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Thr Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Asp Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Ser Ala Ala His Gly Met Asp Val Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Val Thr Val Ser Ser 
        115             


<210>  227
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab26 LCDR1 (Kabat)

<400>  227

Arg Ala Ser Gln Gly Ile Ser Ser Trp Leu Ala 
1               5                   10      


<210>  228
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab26 LCDR2 (Kabat)

<400>  228

Ala Ala Ser Ser Leu Gln Ser 
1               5           


<210>  229
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab26 LCDR3 (Kabat)

<400>  229

Gln Gln Tyr Asn Ser Tyr Pro Tyr Thr 
1               5                   


<210>  230
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab26 VL

<400>  230

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Glu Lys Ala Pro Lys Ser Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Ser Tyr Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105             


<210>  231
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab28 HCDR1 (Kabat)

<400>  231

Ser Tyr Gly Ile Ser 
1               5   


<210>  232
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab28 LCDR2 (Kabat)

<400>  232

Trp Ile Ser Ala Tyr Asn Gly Asn Thr Lys Tyr Ala Gln Lys Leu Gln 
1               5                   10                  15      


Gly 
    


<210>  233
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab28 HCDR3 (Kabat)

<400>  233

Asp Ser Ala Ala His Gly Met Asp Val 
1               5                   


<210>  234
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab28 VH

<400>  234

Gln Val Gln Val Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Thr Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Gly Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Ser Ala Tyr Asn Gly Asn Thr Lys Tyr Ala Gln Lys Leu 
    50                  55                  60                  


Gln Gly Arg Leu Thr Met Thr Thr Asp Thr Ser Thr Thr Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Ser Ala Ala His Gly Met Asp Val Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Val Ser Val Ser Ser 
        115             


<210>  235
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab28 LCDR1 (Kabat)

<400>  235

Arg Ala Ser Gln Gly Ile Ser Ser Trp Leu Ala 
1               5                   10      


<210>  236
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab28 LCDR2 (Kabat)

<400>  236

Ala Ala Ser Ser Leu Gln Ser 
1               5           


<210>  237
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab28 LCDR3 (Kabat)

<400>  237

Gln Gln Tyr Asn Ser Tyr Pro Tyr Thr 
1               5                   


<210>  238
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab28 VL

<400>  238

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Glu Lys Ala Pro Lys Ser Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Ser Tyr Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105             


<210>  239
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  6G11 HCDR1 (Kabat)

<400>  239

Ser Tyr Gly Met His 
1               5   


<210>  240
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  6G11 HCDR2 (Kabat)

<400>  240

Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  241
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  6G11 HCDR3 (Kabat)

<400>  241

Glu Leu Tyr Asp Ala Phe Asp Ile 
1               5               


<210>  242
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  6G11 VH

<400>  242

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Ala Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Leu Tyr Asp Ala Phe Asp Ile Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  243
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  6G11 LCDR1 (Kabat)

<400>  243

Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly Tyr Asp Val His 
1               5                   10                  


<210>  244
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  6G11 LCDR2 (Kabat)

<400>  244

Ala Asp Asp His Arg Pro Ser 
1               5           


<210>  245
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  6G11 LCDR3 (Kabat)

<400>  245

Ala Ser Trp Asp Asp Ser Gln Arg Ala Val Ile 
1               5                   10      


<210>  246
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  6G11 VL

<400>  246

Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 
            20                  25                  30          


Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Ala Asp Asp His Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu 
65                  70                  75                  80  


Arg Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ser Trp Asp Asp Ser 
                85                  90                  95      


Gln Arg Ala Val Ile Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         


<210>  247
<211>  317
<212>  PRT
<213>  Homo sapiens

<220>
<223>  H167 CD32a UniProtKB P12318

<400>  247

Met Thr Met Glu Thr Gln Met Ser Gln Asn Val Cys Pro Arg Asn Leu 
1               5                   10                  15      


Trp Leu Leu Gln Pro Leu Thr Val Leu Leu Leu Leu Ala Ser Ala Asp 
            20                  25                  30          


Ser Gln Ala Ala Ala Pro Pro Lys Ala Val Leu Lys Leu Glu Pro Pro 
        35                  40                  45              


Trp Ile Asn Val Leu Gln Glu Asp Ser Val Thr Leu Thr Cys Gln Gly 
    50                  55                  60                  


Ala Arg Ser Pro Glu Ser Asp Ser Ile Gln Trp Phe His Asn Gly Asn 
65                  70                  75                  80  


Leu Ile Pro Thr His Thr Gln Pro Ser Tyr Arg Phe Lys Ala Asn Asn 
                85                  90                  95      


Asn Asp Ser Gly Glu Tyr Thr Cys Gln Thr Gly Gln Thr Ser Leu Ser 
            100                 105                 110         


Asp Pro Val His Leu Thr Val Leu Ser Glu Trp Leu Val Leu Gln Thr 
        115                 120                 125             


Pro His Leu Glu Phe Gln Glu Gly Glu Thr Ile Met Leu Arg Cys His 
    130                 135                 140                 


Ser Trp Lys Asp Lys Pro Leu Val Lys Val Thr Phe Phe Gln Asn Gly 
145                 150                 155                 160 


Lys Ser Gln Lys Phe Ser His Leu Asp Pro Thr Phe Ser Ile Pro Gln 
                165                 170                 175     


Ala Asn His Ser His Ser Gly Asp Tyr His Cys Thr Gly Asn Ile Gly 
            180                 185                 190         


Tyr Thr Leu Phe Ser Ser Lys Pro Val Thr Ile Thr Val Gln Val Pro 
        195                 200                 205             


Ser Met Gly Ser Ser Ser Pro Met Gly Ile Ile Val Ala Val Val Ile 
    210                 215                 220                 


Ala Thr Ala Val Ala Ala Ile Val Ala Ala Val Val Ala Leu Ile Tyr 
225                 230                 235                 240 


Cys Arg Lys Lys Arg Ile Ser Ala Asn Ser Thr Asp Pro Val Lys Ala 
                245                 250                 255     


Ala Gln Phe Glu Pro Pro Gly Arg Gln Met Ile Ala Ile Arg Lys Arg 
            260                 265                 270         


Gln Leu Glu Glu Thr Asn Asn Asp Tyr Glu Thr Ala Asp Gly Gly Tyr 
        275                 280                 285             


Met Thr Leu Asn Pro Arg Ala Pro Thr Asp Asp Asp Lys Asn Ile Tyr 
    290                 295                 300                 


Leu Thr Leu Pro Pro Asn Asp His Val Asn Ser Asn Asn 
305                 310                 315         


<210>  248
<211>  310
<212>  PRT
<213>  Homo sapiens

<220>
<223>  CD32b variant 1 UniProtKB P31994-1

<400>  248

Met Gly Ile Leu Ser Phe Leu Pro Val Leu Ala Thr Glu Ser Asp Trp 
1               5                   10                  15      


Ala Asp Cys Lys Ser Pro Gln Pro Trp Gly His Met Leu Leu Trp Thr 
            20                  25                  30          


Ala Val Leu Phe Leu Ala Pro Val Ala Gly Thr Pro Ala Ala Pro Pro 
        35                  40                  45              


Lys Ala Val Leu Lys Leu Glu Pro Gln Trp Ile Asn Val Leu Gln Glu 
    50                  55                  60                  


Asp Ser Val Thr Leu Thr Cys Arg Gly Thr His Ser Pro Glu Ser Asp 
65                  70                  75                  80  


Ser Ile Gln Trp Phe His Asn Gly Asn Leu Ile Pro Thr His Thr Gln 
                85                  90                  95      


Pro Ser Tyr Arg Phe Lys Ala Asn Asn Asn Asp Ser Gly Glu Tyr Thr 
            100                 105                 110         


Cys Gln Thr Gly Gln Thr Ser Leu Ser Asp Pro Val His Leu Thr Val 
        115                 120                 125             


Leu Ser Glu Trp Leu Val Leu Gln Thr Pro His Leu Glu Phe Gln Glu 
    130                 135                 140                 


Gly Glu Thr Ile Val Leu Arg Cys His Ser Trp Lys Asp Lys Pro Leu 
145                 150                 155                 160 


Val Lys Val Thr Phe Phe Gln Asn Gly Lys Ser Lys Lys Phe Ser Arg 
                165                 170                 175     


Ser Asp Pro Asn Phe Ser Ile Pro Gln Ala Asn His Ser His Ser Gly 
            180                 185                 190         


Asp Tyr His Cys Thr Gly Asn Ile Gly Tyr Thr Leu Tyr Ser Ser Lys 
        195                 200                 205             


Pro Val Thr Ile Thr Val Gln Ala Pro Ser Ser Ser Pro Met Gly Ile 
    210                 215                 220                 


Ile Val Ala Val Val Thr Gly Ile Ala Val Ala Ala Ile Val Ala Ala 
225                 230                 235                 240 


Val Val Ala Leu Ile Tyr Cys Arg Lys Lys Arg Ile Ser Ala Leu Pro 
                245                 250                 255     


Gly Tyr Pro Glu Cys Arg Glu Met Gly Glu Thr Leu Pro Glu Lys Pro 
            260                 265                 270         


Ala Asn Pro Thr Asn Pro Asp Glu Ala Asp Lys Val Gly Ala Glu Asn 
        275                 280                 285             


Thr Ile Thr Tyr Ser Leu Leu Met His Pro Asp Ala Leu Glu Glu Pro 
    290                 295                 300                 


Asp Asp Gln Asn Arg Ile 
305                 310 


<210>  249
<211>  291
<212>  PRT
<213>  Homo sapiens

<220>
<223>  CD32b variant 2 UniProtKB P31994-2

<400>  249

Met Gly Ile Leu Ser Phe Leu Pro Val Leu Ala Thr Glu Ser Asp Trp 
1               5                   10                  15      


Ala Asp Cys Lys Ser Pro Gln Pro Trp Gly His Met Leu Leu Trp Thr 
            20                  25                  30          


Ala Val Leu Phe Leu Ala Pro Val Ala Gly Thr Pro Ala Ala Pro Pro 
        35                  40                  45              


Lys Ala Val Leu Lys Leu Glu Pro Gln Trp Ile Asn Val Leu Gln Glu 
    50                  55                  60                  


Asp Ser Val Thr Leu Thr Cys Arg Gly Thr His Ser Pro Glu Ser Asp 
65                  70                  75                  80  


Ser Ile Gln Trp Phe His Asn Gly Asn Leu Ile Pro Thr His Thr Gln 
                85                  90                  95      


Pro Ser Tyr Arg Phe Lys Ala Asn Asn Asn Asp Ser Gly Glu Tyr Thr 
            100                 105                 110         


Cys Gln Thr Gly Gln Thr Ser Leu Ser Asp Pro Val His Leu Thr Val 
        115                 120                 125             


Leu Ser Glu Trp Leu Val Leu Gln Thr Pro His Leu Glu Phe Gln Glu 
    130                 135                 140                 


Gly Glu Thr Ile Val Leu Arg Cys His Ser Trp Lys Asp Lys Pro Leu 
145                 150                 155                 160 


Val Lys Val Thr Phe Phe Gln Asn Gly Lys Ser Lys Lys Phe Ser Arg 
                165                 170                 175     


Ser Asp Pro Asn Phe Ser Ile Pro Gln Ala Asn His Ser His Ser Gly 
            180                 185                 190         


Asp Tyr His Cys Thr Gly Asn Ile Gly Tyr Thr Leu Tyr Ser Ser Lys 
        195                 200                 205             


Pro Val Thr Ile Thr Val Gln Ala Pro Ser Ser Ser Pro Met Gly Ile 
    210                 215                 220                 


Ile Val Ala Val Val Thr Gly Ile Ala Val Ala Ala Ile Val Ala Ala 
225                 230                 235                 240 


Val Val Ala Leu Ile Tyr Cys Arg Lys Lys Arg Ile Ser Ala Asn Pro 
                245                 250                 255     


Thr Asn Pro Asp Glu Ala Asp Lys Val Gly Ala Glu Asn Thr Ile Thr 
            260                 265                 270         


Tyr Ser Leu Leu Met His Pro Asp Ala Leu Glu Glu Pro Asp Asp Gln 
        275                 280                 285             


Asn Arg Ile 
    290     


<210>  250
<211>  17
<212>  PRT
<213>  Homo sapiens

<220>
<223>  NOV2108 binding epitope

<400>  250

Val Leu Arg Cys His Ser Trp Lys Asp Lys Pro Leu Val Lys Val Thr 
1               5                   10                  15      


Phe 
    


<210>  251
<211>  162
<212>  PRT
<213>  Homo sapiens

<220>
<223>  IL-15 (with signal peptide)  

<400>  251

Met Arg Ile Ser Lys Pro His Leu Arg Ser Ile Ser Ile Gln Cys Tyr 
1               5                   10                  15      


Leu Cys Leu Leu Leu Asn Ser His Phe Leu Thr Glu Ala Gly Ile His 
            20                  25                  30          


Val Phe Ile Leu Gly Cys Phe Ser Ala Gly Leu Pro Lys Thr Glu Ala 
        35                  40                  45              


Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys Ile Glu Asp Leu Ile 
    50                  55                  60                  


Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr Glu Ser Asp Val His 
65                  70                  75                  80  


Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe Leu Leu Glu Leu Gln 
                85                  90                  95      


Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile His Asp Thr Val Glu 
            100                 105                 110         


Asn Leu Ile Ile Leu Ala Asn Asn Ser Leu Ser Ser Asn Gly Asn Val 
        115                 120                 125             


Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu Lys Asn Ile 
    130                 135                 140                 


Lys Glu Phe Leu Gln Ser Phe Val His Ile Val Gln Met Phe Ile Asn 
145                 150                 155                 160 


Thr Ser 
        


<210>  252
<211>  489
<212>  DNA
<213>  Homo sapiens

<220>
<223>  	Immature/precursor form of human IL-15 including signal peptide DNA 

<400>  252
atgagaattt cgaaaccaca tttgagaagt atttccatcc agtgctactt gtgtttactt       60

ctaaacagtc attttctaac tgaagctggc attcatgtct tcattttggg ctgtttcagt      120

gcagggcttc ctaaaacaga agccaactgg gtgaatgtaa taagtgattt gaaaaaaatt      180

gaagatctta ttcaatctat gcatattgat gctactttat atacggaaag tgatgttcac      240

cccagttgca aagtaacagc aatgaagtgc tttctcttgg agttacaagt tatttcactt      300

gagtccggag atgcaagtat tcatgataca gtagaaaatc tgatcatcct agcaaacaac      360

agtttgtctt ctaatgggaa tgtaacagaa tctggatgca aagaatgtga ggaactggag      420

gaaaaaaata ttaaagaatt tttgcagagt tttgtacata ttgtccaaat gttcatcaac      480

acttcttga                                                              489


<210>  253
<211>  396
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  human IL-15 with GMCSF signal peptide

<400>  253
atgtggctcc agagcctgct actcctgggg acggtggcct gcagcatctc gaactgggtg       60

aacgtgatct cggacctgaa gaagatcgag gacctcatcc agtcgatgca catcgacgcg      120

acgctgtaca cggagtcgga cgtccacccg tcgtgcaagg tcacggcgat gaagtgcttc      180

ctcctggagc tccaagtcat ctcgctcgag tcgggggacg cgtcgatcca cgacacggtg      240

gagaacctga tcatcctggc gaacaactcg ctgtcgtcga acgggaacgt cacggagtcg      300

ggctgcaagg agtgcgagga gctggaggag aagaacatca aggagttcct gcagtcgttc      360

gtgcacatcg tccagatgtt catcaacacg tcgtga                                396


<210>  254
<211>  1847
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IL-15 codon optimized DNA

<400>  254
cctggccatt gcatacgttg tatccatatc ataatatgta catttatatt ggctcatgtc       60

caacattacc gccatgttga cattgattat tgactagtta ttaatagtaa tcaattacgg      120

ggtcattagt tcatagccca tatatggagt tccgcgttac ataacttacg gtaaatggcc      180

cgcctggctg accgcccaac gacccccgcc cattgacgtc aataatgacg tatgttccca      240

tagtaacgcc aatagggact ttccattgac gtcaatgggt ggagtattta cggtaaactg      300

cccacttggc agtacatcaa gtgtatcata tgccaagtac gccccctatt gacgtcaatg      360

atggtaaatg gcccgcctgg cattatgccc agtacatgac cttatgggac tttcctactt      420

ggcagtacat ctacgtatta gtcatcgcta ttaccatggt gatgcggttt tggcagtaca      480

tcaatgggcg tggatagcgg tttgactcac ggggatttcc aagtctccac cccattgacg      540

tcaatgggag tttgttttgg caccaaaatc aacgggactt tccaaaatgt cgtaacaact      600

ccgccccatt gacgcaaatg ggcggtaggc gtgtacggtg ggaggtctat ataagcagag      660

ctcgtttagt gaaccgtcag atcgcctgga gacgccatcc acgctgtttt gacctccata      720

gaagacaccg ggaccgatcc agcctccgcg ggcgcgcgtc gacaagaaat gcggatctcg      780

aagccgcacc tgcggtcgat atcgatccag tgctacctgt gcctgctcct gaactcgcac      840

ttcctcacgg aggccggtat acacgtcttc atcctgggct gcttctcggc ggggctgccg      900

aagacggagg cgaactgggt gaacgtgatc tcggacctga agaagatcga ggacctcatc      960

cagtcgatgc acatcgacgc gacgctgtac acggagtcgg acgtccaccc gtcgtgcaag     1020

gtcacggcga tgaagtgctt cctcctggag ctccaagtca tctcgctcga gtcgggggac     1080

gcgtcgatcc acgacacggt ggagaacctg atcatcctgg cgaacaactc gctgtcgtcg     1140

aacgggaacg tcacggagtc gggctgcaag gagtgcgagg agctggagga gaagaacatc     1200

aaggagttcc tgcagtcgtt cgtgcacatc gtccagatgt tcatcaacac gtcgtgaggg     1260

cccggcgcgc cgaattcgcg gatatcggtt aacggatcca gatctgctgt gccttctagt     1320

tgccagccat ctgttgtttg cccctccccc gtgccttcct tgaccctgga aggtgccact     1380

cccactgtcc tttcctaata aaatgaggaa attgcatcgc attgtctgag taggtgtcat     1440

tctattctgg ggggtggggt ggggcaggac agcaaggggg aggattggga agacaatagc     1500

aggcatgctg gggatgcggt gggctctatg ggtacccagg tgctgaagaa ttgacccggt     1560

tcctcctggg ccagaaagaa gcaggcacat ccccttctct gtgacacacc ctgtccacgc     1620

ccctggttct tagttccagc cccactcata ggacactcat agctcaggag ggctccgcct     1680

tcaatcccac ccgctaaagt acttggagcg gtctctccct ccctcatcag cccaccaaac     1740

caaacctagc ctccaagagt gggaagaaat taaagcaaga taggctatta agtgcagagg     1800

gagagaaaat gcctccaaca tgtgaggaag taatgagaga aatcata                   1847


<210>  255
<211>  162
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL-15 codon optimized

<400>  255

Met Arg Ile Ser Lys Pro His Leu Arg Ser Ile Ser Ile Gln Cys Tyr 
1               5                   10                  15      


Leu Cys Leu Leu Leu Asn Ser His Phe Leu Thr Glu Ala Gly Ile His 
            20                  25                  30          


Val Phe Ile Leu Gly Cys Phe Ser Ala Gly Leu Pro Lys Thr Glu Ala 
        35                  40                  45              


Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys Ile Glu Asp Leu Ile 
    50                  55                  60                  


Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr Glu Ser Asp Val His 
65                  70                  75                  80  


Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe Leu Leu Glu Leu Gln 
                85                  90                  95      


Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile His Asp Thr Val Glu 
            100                 105                 110         


Asn Leu Ile Ile Leu Ala Asn Asn Ser Leu Ser Ser Asn Gly Asn Val 
        115                 120                 125             


Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu Lys Asn Ile 
    130                 135                 140                 


Lys Glu Phe Leu Gln Ser Phe Val His Ile Val Gln Met Phe Ile Asn 
145                 150                 155                 160 


Thr Ser 
        


<210>  256
<211>  267
<212>  PRT
<213>  Homo sapiens

<220>
<223>  Immature IL-15Ra (full length with signal peptide)

<400>  256

Met Ala Pro Arg Arg Ala Arg Gly Cys Arg Thr Leu Gly Leu Pro Ala 
1               5                   10                  15      


Leu Leu Leu Leu Leu Leu Leu Arg Pro Pro Ala Thr Arg Gly Ile Thr 
            20                  25                  30          


Cys Pro Pro Pro Met Ser Val Glu His Ala Asp Ile Trp Val Lys Ser 
        35                  40                  45              


Tyr Ser Leu Tyr Ser Arg Glu Arg Tyr Ile Cys Asn Ser Gly Phe Lys 
    50                  55                  60                  


Arg Lys Ala Gly Thr Ser Ser Leu Thr Glu Cys Val Leu Asn Lys Ala 
65                  70                  75                  80  


Thr Asn Val Ala His Trp Thr Thr Pro Ser Leu Lys Cys Ile Arg Asp 
                85                  90                  95      


Pro Ala Leu Val His Gln Arg Pro Ala Pro Pro Ser Thr Val Thr Thr 
            100                 105                 110         


Ala Gly Val Thr Pro Gln Pro Glu Ser Leu Ser Pro Ser Gly Lys Glu 
        115                 120                 125             


Pro Ala Ala Ser Ser Pro Ser Ser Asn Asn Thr Ala Ala Thr Thr Ala 
    130                 135                 140                 


Ala Ile Val Pro Gly Ser Gln Leu Met Pro Ser Lys Ser Pro Ser Thr 
145                 150                 155                 160 


Gly Thr Thr Glu Ile Ser Ser His Glu Ser Ser His Gly Thr Pro Ser 
                165                 170                 175     


Gln Thr Thr Ala Lys Asn Trp Glu Leu Thr Ala Ser Ala Ser His Gln 
            180                 185                 190         


Pro Pro Gly Val Tyr Pro Gln Gly His Ser Asp Thr Thr Val Ala Ile 
        195                 200                 205             


Ser Thr Ser Thr Val Leu Leu Cys Gly Leu Ser Ala Val Ser Leu Leu 
    210                 215                 220                 


Ala Cys Tyr Leu Lys Ser Arg Gln Thr Pro Pro Leu Ala Ser Val Glu 
225                 230                 235                 240 


Met Glu Ala Met Glu Ala Leu Pro Val Thr Trp Gly Thr Ser Ser Arg 
                245                 250                 255     


Asp Glu Asp Leu Glu Asn Cys Ser His His Leu 
            260                 265         


<210>  257
<211>  200
<212>  PRT
<213>  Homo sapiens

<220>
<223>  Immature IL-15Ra (soluble human PQG termination with signal peptide)

<400>  257

Met Ala Pro Arg Arg Ala Arg Gly Cys Arg Thr Leu Gly Leu Pro Ala 
1               5                   10                  15      


Leu Leu Leu Leu Leu Leu Leu Arg Pro Pro Ala Thr Arg Gly Ile Thr 
            20                  25                  30          


Cys Pro Pro Pro Met Ser Val Glu His Ala Asp Ile Trp Val Lys Ser 
        35                  40                  45              


Tyr Ser Leu Tyr Ser Arg Glu Arg Tyr Ile Cys Asn Ser Gly Phe Lys 
    50                  55                  60                  


Arg Lys Ala Gly Thr Ser Ser Leu Thr Glu Cys Val Leu Asn Lys Ala 
65                  70                  75                  80  


Thr Asn Val Ala His Trp Thr Thr Pro Ser Leu Lys Cys Ile Arg Asp 
                85                  90                  95      


Pro Ala Leu Val His Gln Arg Pro Ala Pro Pro Ser Thr Val Thr Thr 
            100                 105                 110         


Ala Gly Val Thr Pro Gln Pro Glu Ser Leu Ser Pro Ser Gly Lys Glu 
        115                 120                 125             


Pro Ala Ala Ser Ser Pro Ser Ser Asn Asn Thr Ala Ala Thr Thr Ala 
    130                 135                 140                 


Ala Ile Val Pro Gly Ser Gln Leu Met Pro Ser Lys Ser Pro Ser Thr 
145                 150                 155                 160 


Gly Thr Thr Glu Ile Ser Ser His Glu Ser Ser His Gly Thr Pro Ser 
                165                 170                 175     


Gln Thr Thr Ala Lys Asn Trp Glu Leu Thr Ala Ser Ala Ser His Gln 
            180                 185                 190         


Pro Pro Gly Val Tyr Pro Gln Gly 
        195                 200 


<210>  258
<211>  804
<212>  DNA
<213>  Homo sapiens

<220>
<223>  Immature form of the full length human IL-15Ra DNA 

<400>  258
atggccccgc ggcgggcgcg cggctgccgg accctcggtc tcccggcgct gctactgctg       60

ctgctgctcc ggccgccggc gacgcggggc atcacgtgcc ctccccccat gtccgtggaa      120

cacgcagaca tctgggtcaa gagctacagc ttgtactcca gggagcggta catttgtaac      180

tctggtttca agcgtaaagc cggcacgtcc agcctgacgg agtgcgtgtt gaacaaggcc      240

acgaatgtcg cccactggac aacccccagt ctcaaatgca ttagagaccc tgccctggtt      300

caccaaaggc cagcgccacc ctccacagta acgacggcag gggtgacccc acagccagag      360

agcctctccc cttctggaaa agagcccgca gcttcatctc ccagctcaaa caacacagcg      420

gccacaacag cagctattgt cccgggctcc cagctgatgc cttcaaaatc accttccaca      480

ggaaccacag agataagcag tcatgagtcc tcccacggca ccccctctca gacaacagcc      540

aagaactggg aactcacagc atccgcctcc caccagccgc caggtgtgta tccacagggc      600

cacagcgaca ccactgtggc tatctccacg tccactgtcc tgctgtgtgg gctgagcgct      660

gtgtctctcc tggcatgcta cctcaagtca aggcaaactc ccccgctggc cagcgttgaa      720

atggaagcca tggaggctct gccggtgact tgggggacca gcagcagaga tgaagacttg      780

gaaaactgct ctcaccacct atga                                             804


<210>  259
<211>  600
<212>  DNA
<213>  Homo sapiens

<220>
<223>  Immature form of the soluble human IL-15Ra DNA 

<400>  259
atggccccgc ggcgggcgcg cggctgccgg accctcggtc tcccggcgct gctactgctg       60

ctgctgctcc ggccgccggc gacgcggggc atcacgtgcc ctccccccat gtccgtggaa      120

cacgcagaca tctgggtcaa gagctacagc ttgtactcca gggagcggta catttgtaac      180

tctggtttca agcgtaaagc cggcacgtcc agcctgacgg agtgcgtgtt gaacaaggcc      240

acgaatgtcg cccactggac aacccccagt ctcaaatgca ttagagaccc tgccctggtt      300

caccaaaggc cagcgccacc ctccacagta acgacggcag gggtgacccc acagccagag      360

agcctctccc cttctggaaa agagcccgca gcttcatctc ccagctcaaa caacacagcg      420

gccacaacag cagctattgt cccgggctcc cagctgatgc cttcaaaatc accttccaca      480

ggaaccacag agataagcag tcatgagtcc tcccacggca ccccctctca gacaacagcc      540

aagaactggg aactcacagc atccgcctcc caccagccgc caggtgtgta tccacagggc      600


<210>  260
<211>  170
<212>  PRT
<213>  Homo sapiens

<220>
<223>  IL-15Ra minus signal peptide with PQG termination 

<400>  260

Ile Thr Cys Pro Pro Pro Met Ser Val Glu His Ala Asp Ile Trp Val 
1               5                   10                  15      


Lys Ser Tyr Ser Leu Tyr Ser Arg Glu Arg Tyr Ile Cys Asn Ser Gly 
            20                  25                  30          


Phe Lys Arg Lys Ala Gly Thr Ser Ser Leu Thr Glu Cys Val Leu Asn 
        35                  40                  45              


Lys Ala Thr Asn Val Ala His Trp Thr Thr Pro Ser Leu Lys Cys Ile 
    50                  55                  60                  


Arg Asp Pro Ala Leu Val His Gln Arg Pro Ala Pro Pro Ser Thr Val 
65                  70                  75                  80  


Thr Thr Ala Gly Val Thr Pro Gln Pro Glu Ser Leu Ser Pro Ser Gly 
                85                  90                  95      


Lys Glu Pro Ala Ala Ser Ser Pro Ser Ser Asn Asn Thr Ala Ala Thr 
            100                 105                 110         


Thr Ala Ala Ile Val Pro Gly Ser Gln Leu Met Pro Ser Lys Ser Pro 
        115                 120                 125             


Ser Thr Gly Thr Thr Glu Ile Ser Ser His Glu Ser Ser His Gly Thr 
    130                 135                 140                 


Pro Ser Gln Thr Thr Ala Lys Asn Trp Glu Leu Thr Ala Ser Ala Ser 
145                 150                 155                 160 


His Gln Pro Pro Gly Val Tyr Pro Gln Gly 
                165                 170 


<210>  261
<211>  2140
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  huIL15Ra - nucleic acid construct encoding optimized human 
       IL-15Ra

<400>  261
cctggccatt gcatacgttg tatccatatc ataatatgta catttatatt ggctcatgtc       60

caacattacc gccatgttga cattgattat tgactagtta ttaatagtaa tcaattacgg      120

ggtcattagt tcatagccca tatatggagt tccgcgttac ataacttacg gtaaatggcc      180

cgcctggctg accgcccaac gacccccgcc cattgacgtc aataatgacg tatgttccca      240

tagtaacgcc aatagggact ttccattgac gtcaatgggt ggagtattta cggtaaactg      300

cccacttggc agtacatcaa gtgtatcata tgccaagtac gccccctatt gacgtcaatg      360

atggtaaatg gcccgcctgg cattatgccc agtacatgac cttatgggac tttcctactt      420

ggcagtacat ctacgtatta gtcatcgcta ttaccatggt gatgcggttt tggcagtaca      480

tcaatgggcg tggatagcgg tttgactcac ggggatttcc aagtctccac cccattgacg      540

tcaatgggag tttgttttgg caccaaaatc aacgggactt tccaaaatgt cgtaacaact      600

ccgccccatt gacgcaaatg ggcggtaggc gtgtacggtg ggaggtctat ataagcagag      660

ctcgtttagt gaaccgtcag atcgcctgga gacgccatcc acgctgtttt gacctccata      720

gaagacaccg ggaccgatcc agcctccgcg ggcgcgcgtc gacgctagca agaaatggcc      780

ccgaggcggg cgcgaggctg ccggaccctc ggtctcccgg cgctgctact gctcctgctg      840

ctccggccgc cggcgacgcg gggcatcacg tgcccgcccc ccatgtccgt ggagcacgca      900

gacatctggg tcaagagcta cagcttgtac tcccgggagc ggtacatctg caactcgggt      960

ttcaagcgga aggccggcac gtccagcctg acggagtgcg tgttgaacaa ggccacgaat     1020

gtcgcccact ggacgacccc ctcgctcaag tgcatccgcg acccggccct ggttcaccag     1080

cggcccgcgc caccctccac cgtaacgacg gcgggggtga ccccgcagcc ggagagcctc     1140

tccccgtcgg gaaaggagcc cgccgcgtcg tcgcccagct cgaacaacac ggcggccaca     1200

actgcagcga tcgtcccggg ctcccagctg atgccgtcga agtcgccgtc cacgggaacc     1260

acggagatca gcagtcatga gtcctcccac ggcaccccct cgcaaacgac ggccaagaac     1320

tgggaactca cggcgtccgc ctcccaccag ccgccggggg tgtatccgca aggccacagc     1380

gacaccacgg tggcgatctc cacgtccacg gtcctgctgt gtgggctgag cgcggtgtcg     1440

ctcctggcgt gctacctcaa gtcgaggcag actcccccgc tggccagcgt tgagatggag     1500

gccatggagg ctctgccggt gacgtggggg accagcagca gggatgagga cttggagaac     1560

tgctcgcacc acctataatg agaattcgat ccagatctgc tgtgccttct agttgccagc     1620

catctgttgt ttgcccctcc cccgtgcctt ccttgaccct ggaaggtgcc actcccactg     1680

tcctttccta ataaaatgag gaaattgcat cgcattgtct gagtaggtgt cattctattc     1740

tggggggtgg ggtggggcag gacagcaagg gggaggattg ggaagacaat agcaggcatg     1800

ctggggatgc ggtgggctct atgggtaccc aggtgctgaa gaattgaccc ggttcctcct     1860

gggccagaaa gaagcaggca catccccttc tctgtgacac accctgtcca cgcccctggt     1920

tcttagttcc agccccactc ataggacact catagctcag gagggctccg ccttcaatcc     1980

cacccgctaa agtacttgga gcggtctctc cctccctcat cagcccacca aaccaaacct     2040

agcctccaag agtgggaaga aattaaagca agataggcta ttaagtgcag agggagagaa     2100

aatgcctcca acatgtgagg aagtaatgag agaaatcata                           2140


<210>  262
<211>  267
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  huIL15Ra - amino acid sequence of optimized human IL-15Ra

<400>  262

Met Ala Pro Arg Arg Ala Arg Gly Cys Arg Thr Leu Gly Leu Pro Ala 
1               5                   10                  15      


Leu Leu Leu Leu Leu Leu Leu Arg Pro Pro Ala Thr Arg Gly Ile Thr 
            20                  25                  30          


Cys Pro Pro Pro Met Ser Val Glu His Ala Asp Ile Trp Val Lys Ser 
        35                  40                  45              


Tyr Ser Leu Tyr Ser Arg Glu Arg Tyr Ile Cys Asn Ser Gly Phe Lys 
    50                  55                  60                  


Arg Lys Ala Gly Thr Ser Ser Leu Thr Glu Cys Val Leu Asn Lys Ala 
65                  70                  75                  80  


Thr Asn Val Ala His Trp Thr Thr Pro Ser Leu Lys Cys Ile Arg Asp 
                85                  90                  95      


Pro Ala Leu Val His Gln Arg Pro Ala Pro Pro Ser Thr Val Thr Thr 
            100                 105                 110         


Ala Gly Val Thr Pro Gln Pro Glu Ser Leu Ser Pro Ser Gly Lys Glu 
        115                 120                 125             


Pro Ala Ala Ser Ser Pro Ser Ser Asn Asn Thr Ala Ala Thr Thr Ala 
    130                 135                 140                 


Ala Ile Val Pro Gly Ser Gln Leu Met Pro Ser Lys Ser Pro Ser Thr 
145                 150                 155                 160 


Gly Thr Thr Glu Ile Ser Ser His Glu Ser Ser His Gly Thr Pro Ser 
                165                 170                 175     


Gln Thr Thr Ala Lys Asn Trp Glu Leu Thr Ala Ser Ala Ser His Gln 
            180                 185                 190         


Pro Pro Gly Val Tyr Pro Gln Gly His Ser Asp Thr Thr Val Ala Ile 
        195                 200                 205             


Ser Thr Ser Thr Val Leu Leu Cys Gly Leu Ser Ala Val Ser Leu Leu 
    210                 215                 220                 


Ala Cys Tyr Leu Lys Ser Arg Gln Thr Pro Pro Leu Ala Ser Val Glu 
225                 230                 235                 240 


Met Glu Ala Met Glu Ala Leu Pro Val Thr Trp Gly Thr Ser Ser Arg 
                245                 250                 255     


Asp Glu Asp Leu Glu Asn Cys Ser His His Leu 
            260                 265         


<210>  263
<211>  1971
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CMV hu sIL15Ra - nucleic acid construct encoding optimized human 
       IL-15Ra

<400>  263
cctggccatt gcatacgttg tatccatatc ataatatgta catttatatt ggctcatgtc       60

caacattacc gccatgttga cattgattat tgactagtta ttaatagtaa tcaattacgg      120

ggtcattagt tcatagccca tatatggagt tccgcgttac ataacttacg gtaaatggcc      180

cgcctggctg accgcccaac gacccccgcc cattgacgtc aataatgacg tatgttccca      240

tagtaacgcc aatagggact ttccattgac gtcaatgggt ggagtattta cggtaaactg      300

cccacttggc agtacatcaa gtgtatcata tgccaagtac gccccctatt gacgtcaatg      360

atggtaaatg gcccgcctgg cattatgccc agtacatgac cttatgggac tttcctactt      420

ggcagtacat ctacgtatta gtcatcgcta ttaccatggt gatgcggttt tggcagtaca      480

tcaatgggcg tggatagcgg tttgactcac ggggatttcc aagtctccac cccattgacg      540

tcaatgggag tttgttttgg caccaaaatc aacgggactt tccaaaatgt cgtaacaact      600

ccgccccatt gacgcaaatg ggcggtaggc gtgtacggtg ggaggtctat ataagcagag      660

ctcgtttagt gaaccgtcag atcgcctgga gacgccatcc acgctgtttt gacctccata      720

gaagacaccg ggaccgatcc agcctccgcg ggcgcgcgtc gacgctagca agaaatggcc      780

ccgaggcggg cgcgaggctg ccggaccctc ggtctcccgg cgctgctact gctcctgctg      840

ctccggccgc cggcgacgcg gggcatcacg tgcccgcccc ccatgtccgt ggagcacgca      900

gacatctggg tcaagagcta cagcttgtac tcccgggagc ggtacatctg caactcgggt      960

ttcaagcgga aggccggcac gtccagcctg acggagtgcg tgttgaacaa ggccacgaat     1020

gtcgcccact ggacgacccc ctcgctcaag tgcatccgcg acccggccct ggttcaccag     1080

cggcccgcgc caccctccac cgtaacgacg gcgggggtga ccccgcagcc ggagagcctc     1140

tccccgtcgg gaaaggagcc cgccgcgtcg tcgcccagct cgaacaacac ggcggccaca     1200

actgcagcga tcgtcccggg ctcccagctg atgccgtcga agtcgccgtc cacgggaacc     1260

acggagatca gcagtcatga gtcctcccac ggcaccccct cgcaaacgac ggccaagaac     1320

tgggaactca cggcgtccgc ctcccaccag ccgccggggg tgtatccgca aggccacagc     1380

gacaccacgt aatgagaatt cgcggatatc ggttaacgga tccagatctg ctgtgccttc     1440

tagttgccag ccatctgttg tttgcccctc ccccgtgcct tccttgaccc tggaaggtgc     1500

cactcccact gtcctttcct aataaaatga ggaaattgca tcgcattgtc tgagtaggtg     1560

tcattctatt ctggggggtg gggtggggca ggacagcaag ggggaggatt gggaagacaa     1620

tagcaggcat gctggggatg cggtgggctc tatgggtacc caggtgctga agaattgacc     1680

cggttcctcc tgggccagaa agaagcaggc acatcccctt ctctgtgaca caccctgtcc     1740

acgcccctgg ttcttagttc cagccccact cataggacac tcatagctca ggagggctcc     1800

gccttcaatc ccacccgcta aagtacttgg agcggtctct ccctccctca tcagcccacc     1860

aaaccaaacc tagcctccaa gagtgggaag aaattaaagc aagataggct attaagtgca     1920

gagggagaga aaatgcctcc aacatgtgag gaagtaatga gagaaatcat a              1971


<210>  264
<211>  205
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CMV hu sIL15Ra - amino acid sequence of optimized human IL-15Ra

<400>  264

Met Ala Pro Arg Arg Ala Arg Gly Cys Arg Thr Leu Gly Leu Pro Ala 
1               5                   10                  15      


Leu Leu Leu Leu Leu Leu Leu Arg Pro Pro Ala Thr Arg Gly Ile Thr 
            20                  25                  30          


Cys Pro Pro Pro Met Ser Val Glu His Ala Asp Ile Trp Val Lys Ser 
        35                  40                  45              


Tyr Ser Leu Tyr Ser Arg Glu Arg Tyr Ile Cys Asn Ser Gly Phe Lys 
    50                  55                  60                  


Arg Lys Ala Gly Thr Ser Ser Leu Thr Glu Cys Val Leu Asn Lys Ala 
65                  70                  75                  80  


Thr Asn Val Ala His Trp Thr Thr Pro Ser Leu Lys Cys Ile Arg Asp 
                85                  90                  95      


Pro Ala Leu Val His Gln Arg Pro Ala Pro Pro Ser Thr Val Thr Thr 
            100                 105                 110         


Ala Gly Val Thr Pro Gln Pro Glu Ser Leu Ser Pro Ser Gly Lys Glu 
        115                 120                 125             


Pro Ala Ala Ser Ser Pro Ser Ser Asn Asn Thr Ala Ala Thr Thr Ala 
    130                 135                 140                 


Ala Ile Val Pro Gly Ser Gln Leu Met Pro Ser Lys Ser Pro Ser Thr 
145                 150                 155                 160 


Gly Thr Thr Glu Ile Ser Ser His Glu Ser Ser His Gly Thr Pro Ser 
                165                 170                 175     


Gln Thr Thr Ala Lys Asn Trp Glu Leu Thr Ala Ser Ala Ser His Gln 
            180                 185                 190         


Pro Pro Gly Val Tyr Pro Gln Gly His Ser Asp Thr Thr 
        195                 200                 205 


<210>  265
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C-terminal end of the soluble form of human IL-15Ra

<400>  265

Pro Gln Gly His Ser Asp Thr Thr 
1               5               


<210>  266
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C-terminal end of the soluble form of human IL-15Ra

<400>  266

Pro Gln Gly His Ser Asp Thr 
1               5           


<210>  267
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C-terminal end of the soluble form of human IL-15Ra

<400>  267

Pro Gln Gly His Ser Asp 
1               5       


<210>  268
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C-terminal end of the soluble form of human IL-15Ra

<400>  268

Pro Gln Gly His Ser 
1               5   


<210>  269
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C-terminal end of the soluble form of human IL-15Ra

<400>  269

Pro Gln Gly His 
1               


<210>  270
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C-terminal end of the soluble form of human IL-15Ra

<400>  270

Pro Gln Gly 
1           


<210>  271
<211>  175
<212>  PRT
<213>  Homo sapiens

<220>
<223>  Soluble form of human IL-15Ra 

<400>  271

Ile Thr Cys Pro Pro Pro Met Ser Val Glu His Ala Asp Ile Trp Val 
1               5                   10                  15      


Lys Ser Tyr Ser Leu Tyr Ser Arg Glu Arg Tyr Ile Cys Asn Ser Gly 
            20                  25                  30          


Phe Lys Arg Lys Ala Gly Thr Ser Ser Leu Thr Glu Cys Val Leu Asn 
        35                  40                  45              


Lys Ala Thr Asn Val Ala His Trp Thr Thr Pro Ser Leu Lys Cys Ile 
    50                  55                  60                  


Arg Asp Pro Ala Leu Val His Gln Arg Pro Ala Pro Pro Ser Thr Val 
65                  70                  75                  80  


Thr Thr Ala Gly Val Thr Pro Gln Pro Glu Ser Leu Ser Pro Ser Gly 
                85                  90                  95      


Lys Glu Pro Ala Ala Ser Ser Pro Ser Ser Asn Asn Thr Ala Ala Thr 
            100                 105                 110         


Thr Ala Ala Ile Val Pro Gly Ser Gln Leu Met Pro Ser Lys Ser Pro 
        115                 120                 125             


Ser Thr Gly Thr Thr Glu Ile Ser Ser His Glu Ser Ser His Gly Thr 
    130                 135                 140                 


Pro Ser Gln Thr Thr Ala Lys Asn Trp Glu Leu Thr Ala Ser Ala Ser 
145                 150                 155                 160 


His Gln Pro Pro Gly Val Tyr Pro Gln Gly His Ser Asp Thr Thr 
                165                 170                 175 


<210>  272
<211>  19
<212>  PRT
<213>  Homo sapiens

<220>
<223>  IL-15Ra O-glycosylation on Thr5 

<400>  272

Asn Trp Glu Leu Thr Ala Ser Ala Ser His Gln Pro Pro Gly Val Tyr 
1               5                   10                  15      


Pro Gln Gly 
            


<210>  273
<211>  17
<212>  PRT
<213>  Homo sapiens

<220>
<223>  IL-15Ra N-glycosylation on Ser 8 

<400>  273

Ile Thr Cys Pro Pro Pro Met Ser Val Glu His Ala Asp Ile Trp Val 
1               5                   10                  15      


Lys 
    


<210>  274
<211>  31
<212>  PRT
<213>  Homo sapiens

<220>
<223>  IL-15Ra N-glycosylation on Ser 18, 20, 23 or 31 

<400>  274

Ile Thr Cys Pro Pro Pro Met Ser Val Glu His Ala Asp Ile Trp Val 
1               5                   10                  15      


Lys Ser Tyr Ser Leu Tyr Ser Arg Glu Arg Tyr Ile Cys Asn Ser 
            20                  25                  30      


<210>  275
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL-15Ra heterologous protease cleavage site recognized by furin 
       protease Arg-X-X-Arg 

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  Xaa can be any naturally occurring amino acid

<400>  275

Arg Xaa Xaa Arg 
1               


<210>  276
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Il-15Ra heterologous protease cleavage site A-B-Pro-Arg-X-Y


<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  Xaa can be any hydrophobic amino acid

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  Xaa can be any non-acidic amino acid

<400>  276

Xaa Xaa Pro Arg Xaa Xaa 
1               5       


<210>  277
<211>  436
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic sIL-15Ralpha-Fc fusion protein huIL15sRa205-Fc

<400>  277

Met Ala Pro Arg Arg Ala Arg Gly Cys Arg Thr Leu Gly Leu Pro Ala 
1               5                   10                  15      


Leu Leu Leu Leu Leu Leu Leu Arg Pro Pro Ala Thr Arg Gly Ile Thr 
            20                  25                  30          


Cys Pro Pro Pro Met Ser Val Glu His Ala Asp Ile Trp Val Lys Ser 
        35                  40                  45              


Tyr Ser Leu Tyr Ser Arg Glu Arg Tyr Ile Cys Asn Ser Gly Phe Lys 
    50                  55                  60                  


Arg Lys Ala Gly Thr Ser Ser Leu Thr Glu Cys Val Leu Asn Lys Ala 
65                  70                  75                  80  


Thr Asn Val Ala His Trp Thr Thr Pro Ser Leu Lys Cys Ile Arg Asp 
                85                  90                  95      


Pro Ala Leu Val His Gln Arg Pro Ala Pro Pro Ser Thr Val Thr Thr 
            100                 105                 110         


Ala Gly Val Thr Pro Gln Pro Glu Ser Leu Ser Pro Ser Gly Lys Glu 
        115                 120                 125             


Pro Ala Ala Ser Ser Pro Ser Ser Asn Asn Thr Ala Ala Thr Thr Ala 
    130                 135                 140                 


Ala Ile Val Pro Gly Ser Gln Leu Met Pro Ser Lys Ser Pro Ser Thr 
145                 150                 155                 160 


Gly Thr Thr Glu Ile Ser Ser His Glu Ser Ser His Gly Thr Pro Ser 
                165                 170                 175     


Gln Thr Thr Ala Lys Asn Trp Glu Leu Thr Ala Ser Ala Ser His Gln 
            180                 185                 190         


Pro Pro Gly Val Tyr Pro Gln Gly His Ser Asp Thr Thr Pro Lys Ser 
        195                 200                 205             


Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
    210                 215                 220                 


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
225                 230                 235                 240 


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
                245                 250                 255     


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
            260                 265                 270         


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
        275                 280                 285             


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
    290                 295                 300                 


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
305                 310                 315                 320 


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
                325                 330                 335     


Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val 
            340                 345                 350         


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
        355                 360                 365             


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
    370                 375                 380                 


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
385                 390                 395                 400 


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
                405                 410                 415     


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
            420                 425                 430         


Ser Pro Gly Lys 
        435     


<210>  278
<211>  431
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic sIL-15Ralpha-Fc fusion protein huIL15sRa200-Fc

<400>  278

Met Ala Pro Arg Arg Ala Arg Gly Cys Arg Thr Leu Gly Leu Pro Ala 
1               5                   10                  15      


Leu Leu Leu Leu Leu Leu Leu Arg Pro Pro Ala Thr Arg Gly Ile Thr 
            20                  25                  30          


Cys Pro Pro Pro Met Ser Val Glu His Ala Asp Ile Trp Val Lys Ser 
        35                  40                  45              


Tyr Ser Leu Tyr Ser Arg Glu Arg Tyr Ile Cys Asn Ser Gly Phe Lys 
    50                  55                  60                  


Arg Lys Ala Gly Thr Ser Ser Leu Thr Glu Cys Val Leu Asn Lys Ala 
65                  70                  75                  80  


Thr Asn Val Ala His Trp Thr Thr Pro Ser Leu Lys Cys Ile Arg Asp 
                85                  90                  95      


Pro Ala Leu Val His Gln Arg Pro Ala Pro Pro Ser Thr Val Thr Thr 
            100                 105                 110         


Ala Gly Val Thr Pro Gln Pro Glu Ser Leu Ser Pro Ser Gly Lys Glu 
        115                 120                 125             


Pro Ala Ala Ser Ser Pro Ser Ser Asn Asn Thr Ala Ala Thr Thr Ala 
    130                 135                 140                 


Ala Ile Val Pro Gly Ser Gln Leu Met Pro Ser Lys Ser Pro Ser Thr 
145                 150                 155                 160 


Gly Thr Thr Glu Ile Ser Ser His Glu Ser Ser His Gly Thr Pro Ser 
                165                 170                 175     


Gln Thr Thr Ala Lys Asn Trp Glu Leu Thr Ala Ser Ala Ser His Gln 
            180                 185                 190         


Pro Pro Gly Val Tyr Pro Gln Gly Pro Lys Ser Cys Asp Lys Thr His 
        195                 200                 205             


Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
    210                 215                 220                 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
225                 230                 235                 240 


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
                245                 250                 255     


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
            260                 265                 270         


Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
        275                 280                 285             


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
    290                 295                 300                 


Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
305                 310                 315                 320 


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
                325                 330                 335     


Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
            340                 345                 350         


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
        355                 360                 365             


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
    370                 375                 380                 


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
385                 390                 395                 400 


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
                405                 410                 415     


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
            420                 425                 430     


