                               SEQUENCE LISTING

<110> NOVARTIS AG
 
<120> METHOD OF MANUFACTURING BISPECIFIC ANTIBODIES, BISPECIFIC 
      ANTIBODIES AND THERAPEUTIC USE OF SUCH ANTIBODIES

<130> PAT057716-WO-PCT

<140>
<141>

<150> 62/518,090
<151> 2017-06-12

<160> 104   

<170> PatentIn version 3.5

<210> 1
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 1
Ser Tyr Ala Ile Ser 
1               5   


<210> 2
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 2
Asn Ile Ile Pro Met Thr Gly Gln Thr Tyr Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210> 3
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 3
Ala Ala Tyr His Pro Leu Val Phe Asp Asn 
1               5                   10  


<210> 4
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 4
Gly Gly Thr Phe Lys Ser Tyr 
1               5           


<210> 5
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 5
Ile Pro Met Thr Gly Gln 
1               5       


<210> 6
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 6
Ala Ala Tyr His Pro Leu Val Phe Asp Asn 
1               5                   10  


<210> 7
<211> 119
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 7
Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Lys Ser Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Asn Ile Ile Pro Met Thr Gly Gln Thr Tyr Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ala Ala Tyr His Pro Leu Val Phe Asp Asn Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210> 8
<211> 356
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 8
gaggtgcagc tggtgcagag cggcgccgag gtgaagaagc ccggcagcag cgtgaaggtg       60

agctgcaagg ccagcggcgg caccttcaag agctacgcca tcagctgggt gaggcaggcc      120

cccggccagg gcctggagtg gatgggcaac atcatcccca tgaccggcca gacctactac      180

gcccagaagt tccagggcag ggtgaccatc accgccgacg agagcaccag caccgcctac      240

atggagctga gcagcctgag gagcgaggac accgccgtgt actactgcgc cagggccgcc      300

taccaccccc tggtgttcga caactgggcc agggcaccct ggtgaccgtg agcagc          356


<210> 9
<211> 449
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 9
Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Lys Ser Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Asn Ile Ile Pro Met Thr Gly Gln Thr Tyr Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ala Ala Tyr His Pro Leu Val Phe Asp Asn Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
        115                 120                 125             


Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu 
    130                 135                 140                 


Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
145                 150                 155                 160 


Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
                165                 170                 175     


Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
            180                 185                 190         


Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro 
        195                 200                 205             


Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp Lys 
    210                 215                 220                 


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro 
225                 230                 235                 240 


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                245                 250                 255     


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
            260                 265                 270         


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        275                 280                 285             


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
    290                 295                 300                 


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
305                 310                 315                 320 


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
                325                 330                 335     


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
            340                 345                 350         


Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr 
        355                 360                 365             


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    370                 375                 380                 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
385                 390                 395                 400 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
                405                 410                 415     


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            420                 425                 430         


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445             


Lys 
    


<210> 10
<211> 1347
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 10
gaggtgcagc tggtgcagag cggcgccgag gtgaagaagc ccggcagcag cgtgaaggtg       60

agctgcaagg ccagcggcgg caccttcaag agctacgcca tcagctgggt gaggcaggcc      120

cccggccagg gcctggagtg gatgggcaac atcatcccca tgaccggcca gacctactac      180

gcccagaagt tccagggcag ggtgaccatc accgccgacg agagcaccag caccgcctac      240

atggagctga gcagcctgag gagcgaggac accgccgtgt actactgcgc cagggccgcc      300

taccaccccc tggtgttcga caactggggc cagggcaccc tggtgaccgt gagcagcgcc      360

agcaccaagg gccccagcgt gttccccctg gcccccagca gcaagagcac cagcggcggc      420

accgccgccc tgggctgcct ggtgaaggac tacttccccg agcccgtgac cgtgagctgg      480

aacagcggcg ccctgaccag cggcgtgcac accttccccg ccgtgctgca gagcagcggc      540

ctgtacagcc tgagcagcgt ggtgaccgtg cccagcagca gcctgggcac ccagacctac      600

atctgcaacg tgaaccacaa gcccagcaac accaaggtgg acaagagggt ggagcccaag      660

agctgcgaca agacccacac ctgccccccc tgccccgccc ccgaggccgc cggcggcccc      720

agcgtgttcc tgttcccccc caagcccaag gacaccctga tgatcagcag gacccccgag      780

gtgacctgcg tggtggtgga cgtgagccac gaggaccccg aggtgaagtt caactggtac      840

gtggacggcg tggaggtgca caacgccaag accaagccca gggaggagca gtacaacagc      900

acctacaggg tggtgagcgt gctgaccgtg ctgcaccagg actggctgaa cggcaaggag      960

tacaagtgca aggtgagcaa caaggccctg cccgccccca tcgagaagac catcagcaag     1020

gccaagggcc agcccaggga gccccaggtg tacaccctgc cccccagcag ggaggagatg     1080

accaagaacc aggtgagcct gacctgcctg gtgaagggct tctaccccag cgacatcgcc     1140

gtggagtggg agagcaacgg ccagcccgag aacaactaca agaccacccc ccccgtgctg     1200

gacagcgacg gcagcttctt cctgtacagc aagctgaccg tggacaagag caggtggcag     1260

cagggcaacg tgttcagctg cagcgtgatg cacgaggccc tgcacaacca ctacacccag     1320

aagagcctga gcctgagccc cggcaag                                         1347


<210> 11
<211> 13
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 11
Ser Gly Ser Ser Ser Asn Ile Gly Asn His Tyr Val Asn 
1               5                   10              


<210> 12
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 12
Arg Asn Asn His Arg Pro Ser 
1               5           


<210> 13
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 13
Gln Ser Trp Asp Tyr Ser Gly Phe Ser Thr Val 
1               5                   10      


<210> 14
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 14
Ser Ser Ser Asn Ile Gly Asn His Tyr 
1               5                   


<210> 15
<211> 3
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 15
Arg Asn Asn 
1           


<210> 16
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 16
Trp Asp Tyr Ser Gly Phe Ser Thr 
1               5               


<210> 17
<211> 110
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 17
Asp Ile Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn His 
            20                  25                  30          


Tyr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Arg Asn Asn His Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu Gln 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Trp Asp Tyr Ser Gly 
                85                  90                  95      


Phe Ser Thr Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110 


<210> 18
<211> 330
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 18
gatatcgtcc tgactcagcc ccctagcgtc agcggcgctc ccggtcagag agtgactatt       60

agctgtagcg gctctagctc taatatcggt aatcactacg tgaactggta tcagcagctg      120

cccggcaccg cccctaagct gctgatctat agaaacaatc accggcctag cggcgtgccc      180

gataggttta gcggatctaa gtcaggcact agcgctagtc tggctatcac cggactgcag      240

tcagaggacg aggccgacta ctactgtcag tcctgggact atagcggctt tagcaccgtg      300

ttcggcggag gcactaagct gaccgtgctg                                       330


<210> 19
<211> 216
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 19
Asp Ile Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn His 
            20                  25                  30          


Tyr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Arg Asn Asn His Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu Gln 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Trp Asp Tyr Ser Gly 
                85                  90                  95      


Phe Ser Thr Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln 
            100                 105                 110         


Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu 
        115                 120                 125             


Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr 
    130                 135                 140                 


Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys 
145                 150                 155                 160 


Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr 
                165                 170                 175     


Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His 
            180                 185                 190         


Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys 
        195                 200                 205             


Thr Val Ala Pro Thr Glu Cys Ser 
    210                 215     


<210> 20
<211> 648
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 20
gatatcgtcc tgactcagcc ccctagcgtc agcggcgctc ccggtcagag agtgactatt       60

agctgtagcg gctctagctc taatatcggt aatcactacg tgaactggta tcagcagctg      120

cccggcaccg cccctaagct gctgatctat agaaacaatc accggcctag cggcgtgccc      180

gataggttta gcggatctaa gtcaggcact agcgctagtc tggctatcac cggactgcag      240

tcagaggacg aggccgacta ctactgtcag tcctgggact atagcggctt tagcaccgtg      300

ttcggcggag gcactaagct gaccgtgctg ggtcagccta aggctgcccc cagcgtgacc      360

ctgttccccc ccagcagcga ggagctgcag gccaacaagg ccaccctggt gtgcctgatc      420

agcgacttct acccaggcgc cgtgaccgtg gcctggaagg ccgacagcag ccccgtgaag      480

gccggcgtgg agaccaccac ccccagcaag cagagcaaca acaagtacgc cgccagcagc      540

tacctgagcc tgacccccga gcagtggaag agccacaggt cctacagctg ccaggtgacc      600

cacgagggca gcaccgtgga aaagaccgtg gccccaaccg agtgcagc                   648


<210> 21
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 21
Val Tyr Gly Met Asn 
1               5   


<210> 22
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 22
Ile Ile Trp Tyr Asp Gly Asp Asn Gln Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210> 23
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 23
Asp Leu Arg Thr Gly Pro Phe Asp Tyr 
1               5                   


<210> 24
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 24
Gly Phe Thr Phe Ser Val Tyr 
1               5           


<210> 25
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 25
Trp Tyr Asp Gly Asp Asn 
1               5       


<210> 26
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 26
Asp Leu Arg Thr Gly Pro Phe Asp Tyr 
1               5                   


<210> 27
<211> 118
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 27
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Val Tyr 
            20                  25                  30          


Gly Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Ile Ile Trp Tyr Asp Gly Asp Asn Gln Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Gly Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Leu Arg Thr Gly Pro Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210> 28
<211> 354
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 28
caggtgcagc tggtggagag cggcggcggc gtggtgcagc ccggcaggag cctgaggctg       60

agctgcgccg ccagcggctt caccttcagc gtgtacggca tgaactgggt gaggcaggcc      120

cccggcaagg gcctggagtg ggtggccatc atctggtacg acggcgacaa ccagtactac      180

gccgacagcg tgaagggcag gttcaccatc agcagggaca acagcaagaa caccctgtac      240

ctgcagatga acggcctgag ggccgaggac accgccgtgt actactgcgc cagggacctg      300

aggaccggcc ccttcgacta ctggggccag ggcaccctgg tgaccgtgag cagc            354


<210> 29
<211> 448
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 29
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Val Tyr 
            20                  25                  30          


Gly Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Ile Ile Trp Tyr Asp Gly Asp Asn Gln Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Gly Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Leu Arg Thr Gly Pro Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
        115                 120                 125             


Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly 
    130                 135                 140                 


Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
145                 150                 155                 160 


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
                165                 170                 175     


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
            180                 185                 190         


Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser 
        195                 200                 205             


Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp Lys Thr 
    210                 215                 220                 


His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser 
225                 230                 235                 240 


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
                245                 250                 255     


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
            260                 265                 270         


Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
        275                 280                 285             


Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 
    290                 295                 300                 


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
305                 310                 315                 320 


Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 
                325                 330                 335     


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
            340                 345                 350         


Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys 
        355                 360                 365             


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
    370                 375                 380                 


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
385                 390                 395                 400 


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
                405                 410                 415     


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
            420                 425                 430         


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445             


<210> 30
<211> 1344
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 30
caggtgcagc tggtggagag cggcggcggc gtggtgcagc ccggcaggag cctgaggctg       60

agctgcgccg ccagcggctt caccttcagc gtgtacggca tgaactgggt gaggcaggcc      120

cccggcaagg gcctggagtg ggtggccatc atctggtacg acggcgacaa ccagtactac      180

gccgacagcg tgaagggcag gttcaccatc agcagggaca acagcaagaa caccctgtac      240

ctgcagatga acggcctgag ggccgaggac accgccgtgt actactgcgc cagggacctg      300

aggaccggcc ccttcgacta ctggggccag ggcaccctgg tgaccgtgag cagcgccagc      360

accaagggcc ccagcgtgtt ccccctggcc cccagcagca agagcaccag cggcggcacc      420

gccgccctgg gctgcctggt gaaggactac ttccccgagc ccgtgaccgt gagctggaac      480

agcggcgccc tgaccagcgg cgtgcacacc ttccccgccg tgctgcagag cagcggcctg      540

tacagcctga gcagcgtggt gaccgtgccc agcagcagcc tgggcaccca gacctacatc      600

tgcaacgtga accacaagcc cagcaacacc aaggtggaca agagggtgga gcccaagagc      660

tgcgacaaga cccacacctg ccccccctgc cccgcccccg agctgctggg cggccccagc      720

gtgttcctgt tcccccccaa gcccaaggac accctgatga tcagcaggac ccccgaggtg      780

acctgcgtgg tggtggacgt gagccacgag gaccccgagg tgaagttcaa ctggtacgtg      840

gacggcgtgg aggtgcacaa cgccaagacc aagcccaggg aggagcagta caacagcacc      900

tacagggtgg tgagcgtgct gaccgtgctg caccaggact ggctgaacgg caaggagtac      960

aagtgcaagg tgagcaacaa ggccctgccc gcccccatcg agaagaccat cagcaaggcc     1020

aagggccagc ccagggagcc ccaggtgtac accctgcccc ccagcaggga ggagatgacc     1080

aagaaccagg tgagcctgac ctgcctggtg aagggcttct accccagcga catcgccgtg     1140

gagtgggaga gcaacggcca gcccgagaac aactacaaga ccaccccccc cgtgctggac     1200

agcgacggca gcttcttcct gtacagcaag ctgaccgtgg acaagagcag gtggcagcag     1260

ggcaacgtgt tcagctgcag cgtgatgcac gaggccctgc acaaccacta cacccagaag     1320

agcctgagcc tgagccccgg caag                                            1344


<210> 31
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 31
Arg Ala Ser Gln Ser Ile Gly Ser Ser Leu His 
1               5                   10      


<210> 32
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 32
Tyr Ala Ser Gln Ser Phe Ser 
1               5           


<210> 33
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 33
His Gln Ser Ser Ser Leu Pro Phe Thr 
1               5                   


<210> 34
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 34
Ser Gln Ser Ile Gly Ser Ser 
1               5           


<210> 35
<211> 3
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 35
Tyr Ala Ser 
1           


<210> 36
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 36
Ser Ser Ser Leu Pro Phe 
1               5       


<210> 37
<211> 107
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 37
Glu Ile Val Leu Thr Gln Ser Pro Asp Phe Gln Ser Val Thr Pro Lys 
1               5                   10                  15      


Glu Lys Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Gly Ser Ser 
            20                  25                  30          


Leu His Trp Tyr Gln Gln Lys Pro Asp Gln Ser Pro Lys Leu Leu Ile 
        35                  40                  45              


Lys Tyr Ala Ser Gln Ser Phe Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Asn Ser Leu Glu Ala 
65                  70                  75                  80  


Glu Asp Ala Ala Ala Tyr Tyr Cys His Gln Ser Ser Ser Leu Pro Phe 
                85                  90                  95      


Thr Phe Gly Pro Gly Thr Lys Val Asp Ile Lys 
            100                 105         


<210> 38
<211> 321
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 38
gagatcgtgc tgacccagtc acccgacttt cagtcagtga cccctaaaga aaaagtgact       60

atcacctgta gggcctccca gtctatcggc tctagcctgc actggtatca gcagaagccc      120

gatcagtcac ctaagctgct gattaagtac gcctctcagt cctttagcgg cgtgccctct      180

aggtttagcg gctcaggctc aggcaccgac ttcaccctga ctatcaatag cctggaagcc      240

gaggacgccg ctgcctacta ctgtcatcag tcaagtagcc tgcccttcac cttcggccct      300

ggcactaaag tggatattaa g                                                321


<210> 39
<211> 214
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 39
Glu Ile Val Leu Thr Gln Ser Pro Asp Phe Gln Ser Val Thr Pro Lys 
1               5                   10                  15      


Glu Lys Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Gly Ser Ser 
            20                  25                  30          


Leu His Trp Tyr Gln Gln Lys Pro Asp Gln Ser Pro Lys Leu Leu Ile 
        35                  40                  45              


Lys Tyr Ala Ser Gln Ser Phe Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Asn Ser Leu Glu Ala 
65                  70                  75                  80  


Glu Asp Ala Ala Ala Tyr Tyr Cys His Gln Ser Ser Ser Leu Pro Phe 
                85                  90                  95      


Thr Phe Gly Pro Gly Thr Lys Val Asp Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210> 40
<211> 642
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 40
gagatcgtgc tgacccagtc acccgacttt cagtcagtga cccctaaaga aaaagtgact       60

atcacctgta gggcctccca gtctatcggc tctagcctgc actggtatca gcagaagccc      120

gatcagtcac ctaagctgct gattaagtac gcctctcagt cctttagcgg cgtgccctct      180

aggtttagcg gctcaggctc aggcaccgac ttcaccctga ctatcaatag cctggaagcc      240

gaggacgccg ctgcctacta ctgtcatcag tcaagtagcc tgcccttcac cttcggccct      300

ggcactaaag tggatattaa gcgtacggtg gccgctccca gcgtgttcat cttccccccc      360

agcgacgagc agctgaagag cggcaccgcc agcgtggtgt gcctgctgaa caacttctac      420

ccccgggagg ccaaggtgca gtggaaggtg gacaacgccc tgcagagcgg caacagccag      480

gagagcgtca ccgagcagga cagcaaggac tccacctaca gcctgagcag caccctgacc      540

ctgagcaagg ccgactacga gaagcataag gtgtacgcct gcgaggtgac ccaccagggc      600

ctgtccagcc ccgtgaccaa gagcttcaac aggggcgagt gc                         642


<210> 41
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 41
Gly Phe Thr Phe Ser Val Tyr Gly Met Asn 
1               5                   10  


<210> 42
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 42
Ile Ile Trp Tyr Asp Gly Asp Asn Gln Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210> 43
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 43
Asp Leu Arg Thr Gly Pro Phe Asp Tyr 
1               5                   


<210> 44
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 44
Val Tyr Gly Met Asn 
1               5   


<210> 45
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 45
Ile Ile Trp Tyr Asp Gly Asp Asn Gln Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210> 46
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 46
Asp Leu Arg Thr Gly Pro Phe Asp Tyr 
1               5                   


<210> 47
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 47
Gly Phe Thr Phe Ser Val Tyr 
1               5           


<210> 48
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 48
Trp Tyr Asp Gly Asp Asn 
1               5       


<210> 49
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 49
Asp Leu Arg Thr Gly Pro Phe Asp Tyr 
1               5                   


<210> 50
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 50
Gly Phe Thr Phe Ser Val Tyr Gly 
1               5               


<210> 51
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 51
Ile Trp Tyr Asp Gly Asp Asn Gln 
1               5               


<210> 52
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 52
Ala Arg Asp Leu Arg Thr Gly Pro Phe Asp Tyr 
1               5                   10      


<210> 53
<211> 118
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 53
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Val Tyr 
            20                  25                  30          


Gly Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Ile Ile Trp Tyr Asp Gly Asp Asn Gln Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Gly Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Leu Arg Thr Gly Pro Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210> 54
<211> 354
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 54
caggtgcagc tggtggaatc aggcggcgga gtggtgcagc ctggtagatc actgagactg       60

agctgcgctg ctagtggctt cacctttagc gtctacggaa tgaactgggt ccgacaggcc      120

cctgggaaag gcctggagtg ggtggcaatt atctggtacg acggcgataa tcagtactac      180

gccgatagcg tgaagggacg gttcactatc tctagggata actctaagaa caccctgtac      240

ctgcagatga acggcctgag agccgaggac accgccgtct actactgcgc tagggacctg      300

agaaccggcc ccttcgacta ctggggacag ggcaccctgg tcaccgtgtc tagc            354


<210> 55
<211> 448
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 55
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Val Tyr 
            20                  25                  30          


Gly Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Ile Ile Trp Tyr Asp Gly Asp Asn Gln Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Gly Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Leu Arg Thr Gly Pro Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
        115                 120                 125             


Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly 
    130                 135                 140                 


Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
145                 150                 155                 160 


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
                165                 170                 175     


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
            180                 185                 190         


Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser 
        195                 200                 205             


Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp Lys Thr 
    210                 215                 220                 


His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser 
225                 230                 235                 240 


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
                245                 250                 255     


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
            260                 265                 270         


Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
        275                 280                 285             


Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 
    290                 295                 300                 


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
305                 310                 315                 320 


Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 
                325                 330                 335     


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Cys Thr Leu 
            340                 345                 350         


Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Ser Cys 
        355                 360                 365             


Ala Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
    370                 375                 380                 


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
385                 390                 395                 400 


Ser Asp Gly Ser Phe Phe Leu Val Ser Lys Leu Thr Val Asp Lys Ser 
                405                 410                 415     


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
            420                 425                 430         


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445             


<210> 56
<211> 1344
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 56
caggtgcagc tggtggaatc aggcggcgga gtggtgcagc ctggtagatc actgagactg       60

agctgcgctg ctagtggctt cacctttagc gtctacggaa tgaactgggt ccgacaggcc      120

cctgggaaag gcctggagtg ggtggcaatt atctggtacg acggcgataa tcagtactac      180

gccgatagcg tgaagggacg gttcactatc tctagggata actctaagaa caccctgtac      240

ctgcagatga acggcctgag agccgaggac accgccgtct actactgcgc tagggacctg      300

agaaccggcc ccttcgacta ctggggacag ggcaccctgg tcaccgtgtc tagcgcctct      360

actaagggcc caagcgtgtt ccccctggcc cctagctcta agtctactag cggaggcacc      420

gccgctctgg gctgcctggt caaggactac ttccccgagc ccgtgaccgt cagctggaat      480

agcggcgctc tgactagcgg agtgcacacc ttccccgccg tgctgcagtc tagcggcctg      540

tatagcctgt ctagcgtcgt gaccgtgcct agctctagcc tgggcactca gacctatatc      600

tgtaacgtga accacaagcc ctctaacact aaggtggaca agcgggtgga acctaagtcc      660

tgcgataaga ctcacacctg tcctccctgc cctgcccctg aggctgccgg aggacctagc      720

gtgttcctgt tcccacctaa gcctaaagac accctgatga tctctaggac ccccgaagtg      780

acctgcgtgg tggtggacgt ctcacacgag gaccctgaag tgaagtttaa ttggtacgtg      840

gacggcgtgg aagtgcacaa cgctaagact aagcctagag aggaacagta taactctacc      900

tatagggtcg tcagcgtgct gacagtgctg caccaggact ggctgaacgg gaaagagtat      960

aagtgtaaag tgtctaacaa ggccctgcca gcccctatcg aaaagactat ctctaaggct     1020

aaggggcagc ctagagaacc ccaagtgtgc actctgcccc ctagtagaga agagatgact     1080

aagaatcagg tgtcactgag ctgtgccgtg aagggcttct accctagcga tatcgccgtg     1140

gagtgggaga gcaacggcca gcccgagaac aactacaaga ccaccccccc agtgctggac     1200

agcgacggca gcttcttcct ggtgagcaag ctgaccgtgg acaagtccag gtggcagcag     1260

ggcaacgtgt tcagctgcag cgtgatgcac gaggccctgc acaaccacta cacccagaag     1320

tccctgagcc tgagccccgg caag                                            1344


<210> 57
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 57
Arg Ala Ser Gln Ser Ile Gly Ser Ser Leu His 
1               5                   10      


<210> 58
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 58
Tyr Ala Ser Gln Ser Phe Ser 
1               5           


<210> 59
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 59
His Gln Ser Ser Ser Leu Pro Phe Thr 
1               5                   


<210> 60
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 60
Arg Ala Ser Gln Ser Ile Gly Ser Ser Leu His 
1               5                   10      


<210> 61
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 61
Tyr Ala Ser Gln Ser Phe Ser 
1               5           


<210> 62
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 62
His Gln Ser Ser Ser Leu Pro Phe Thr 
1               5                   


<210> 63
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 63
Ser Gln Ser Ile Gly Ser Ser 
1               5           


<210> 64
<211> 3
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 64
Tyr Ala Ser 
1           


<210> 65
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 65
Ser Ser Ser Leu Pro Phe 
1               5       


<210> 66
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 66
Gln Ser Ile Gly Ser Ser 
1               5       


<210> 67
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 67
Tyr Ala Ser Gln Ser Phe Ser Gly Val Pro 
1               5                   10  


<210> 68
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 68
His Gln Ser Ser Ser Leu Pro Phe Thr 
1               5                   


<210> 69
<211> 107
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 69
Glu Ile Val Leu Thr Gln Ser Pro Asp Phe Gln Ser Val Thr Pro Lys 
1               5                   10                  15      


Glu Lys Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Gly Ser Ser 
            20                  25                  30          


Leu His Trp Tyr Gln Gln Lys Pro Asp Gln Ser Pro Lys Leu Leu Ile 
        35                  40                  45              


Lys Tyr Ala Ser Gln Ser Phe Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Asn Ser Leu Glu Ala 
65                  70                  75                  80  


Glu Asp Ala Ala Ala Tyr Tyr Cys His Gln Ser Ser Ser Leu Pro Phe 
                85                  90                  95      


Thr Phe Gly Pro Gly Thr Lys Val Asp Ile Lys 
            100                 105         


<210> 70
<211> 321
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 70
gagatcgtgc tgacccagtc acccgacttt cagtcagtga cccctaaaga aaaagtgact       60

atcacctgta gggcctccca gtctatcggc tctagcctgc actggtatca gcagaagccc      120

gatcagtcac ctaagctgct gattaagtac gcctctcagt cctttagcgg cgtgccctct      180

aggtttagcg gctcaggctc aggcaccgac ttcaccctga ctatcaatag cctggaagcc      240

gaggacgccg ctgcctacta ctgtcatcag tcaagtagcc tgcccttcac cttcggccct      300

ggcactaaag tggatattaa g                                                321


<210> 71
<211> 214
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 71
Glu Ile Val Leu Thr Gln Ser Pro Asp Phe Gln Ser Val Thr Pro Lys 
1               5                   10                  15      


Glu Lys Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Gly Ser Ser 
            20                  25                  30          


Leu His Trp Tyr Gln Gln Lys Pro Asp Gln Ser Pro Lys Leu Leu Ile 
        35                  40                  45              


Lys Tyr Ala Ser Gln Ser Phe Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Asn Ser Leu Glu Ala 
65                  70                  75                  80  


Glu Asp Ala Ala Ala Tyr Tyr Cys His Gln Ser Ser Ser Leu Pro Phe 
                85                  90                  95      


Thr Phe Gly Pro Gly Thr Lys Val Asp Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210> 72
<211> 642
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 72
gagatcgtgc tgacccagtc acccgacttt cagtcagtga cccctaaaga aaaagtgact       60

atcacctgta gggcctccca gtctatcggc tctagcctgc actggtatca gcagaagccc      120

gatcagtcac ctaagctgct gattaagtac gcctctcagt cctttagcgg cgtgccctct      180

aggtttagcg gctcaggctc aggcaccgac ttcaccctga ctatcaatag cctggaagcc      240

gaggacgccg ctgcctacta ctgtcatcag tcaagtagcc tgcccttcac cttcggccct      300

ggcactaaag tggatattaa gcgtacggtg gccgctccca gcgtgttcat cttccccccc      360

agcgacgagc agctgaagag cggcaccgcc agcgtggtgt gcctgctgaa caacttctac      420

ccccgggagg ccaaggtgca gtggaaggtg gacaacgccc tgcagagcgg caacagccag      480

gagagcgtca ccgagcagga cagcaaggac tccacctaca gcctgagcag caccctgacc      540

ctgagcaagg ccgactacga gaagcataag gtgtacgcct gcgaggtgac ccaccagggc      600

ctgtccagcc ccgtgaccaa gagcttcaac aggggcgagt gc                         642


<210> 73
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 73
Gly Gly Thr Phe Lys Ser Tyr Ala Ile Ser 
1               5                   10  


<210> 74
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 74
Asn Ile Ile Pro Met Thr Gly Gln Thr Tyr Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210> 75
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 75
Ala Ala Tyr His Pro Leu Val Phe Asp Asn 
1               5                   10  


<210> 76
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 76
Ser Tyr Ala Ile Ser 
1               5   


<210> 77
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 77
Asn Ile Ile Pro Met Thr Gly Gln Thr Tyr Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210> 78
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 78
Ala Ala Tyr His Pro Leu Val Phe Asp Asn 
1               5                   10  


<210> 79
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 79
Gly Gly Thr Phe Lys Ser Tyr 
1               5           


<210> 80
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 80
Ile Pro Met Thr Gly Gln 
1               5       


<210> 81
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 81
Ala Ala Tyr His Pro Leu Val Phe Asp Asn 
1               5                   10  


<210> 82
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 82
Gly Gly Thr Phe Lys Ser Tyr Ala 
1               5               


<210> 83
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 83
Ile Ile Pro Met Thr Gly Gln Thr 
1               5               


<210> 84
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 84
Ala Arg Ala Ala Tyr His Pro Leu Val Phe Asp Asn 
1               5                   10          


<210> 85
<211> 119
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 85
Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Lys Ser Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Asn Ile Ile Pro Met Thr Gly Gln Thr Tyr Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ala Ala Tyr His Pro Leu Val Phe Asp Asn Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210> 86
<211> 357
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 86
gaggtgcagc tggtgcagtc aggcgccgaa gtgaagaaac ccggctctag cgtgaaagtc       60

agctgtaaag ctagtggcgg caccttcaag tcctacgcta ttagctgggt cagacaggcc      120

ccaggtcagg gcctggagtg gatgggcaat attatcccta tgaccggtca gacctactac      180

gctcagaaat ttcagggtag agtgactatc accgccgacg agtctactag caccgcctat      240

atggaactgt ctagcctgag atcagaggac accgccgtct actactgcgc tagagccgcc      300

tatcaccccc tggtgttcga taactggggt cagggcaccc tggtcaccgt gtctagc         357


<210> 87
<211> 449
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 87
Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Lys Ser Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Asn Ile Ile Pro Met Thr Gly Gln Thr Tyr Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ala Ala Tyr His Pro Leu Val Phe Asp Asn Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
        115                 120                 125             


Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu 
    130                 135                 140                 


Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
145                 150                 155                 160 


Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
                165                 170                 175     


Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
            180                 185                 190         


Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro 
        195                 200                 205             


Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp Lys 
    210                 215                 220                 


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro 
225                 230                 235                 240 


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                245                 250                 255     


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
            260                 265                 270         


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        275                 280                 285             


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
    290                 295                 300                 


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
305                 310                 315                 320 


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
                325                 330                 335     


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
            340                 345                 350         


Leu Pro Pro Cys Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Trp 
        355                 360                 365             


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    370                 375                 380                 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
385                 390                 395                 400 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
                405                 410                 415     


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            420                 425                 430         


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445             


Lys 
    


<210> 88
<211> 1347
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 88
gaggtgcagc tggtgcagtc aggcgccgaa gtgaagaaac ccggctctag cgtgaaagtc       60

agctgtaaag ctagtggcgg caccttcaag tcctacgcta ttagctgggt cagacaggcc      120

ccaggtcagg gcctggagtg gatgggcaat attatcccta tgaccggtca gacctactac      180

gctcagaaat ttcagggtag agtgactatc accgccgacg agtctactag caccgcctat      240

atggaactgt ctagcctgag atcagaggac accgccgtct actactgcgc tagagccgcc      300

tatcaccccc tggtgttcga taactggggt cagggcaccc tggtcaccgt gtctagcgct      360

agcactaagg gcccctcagt gttccccctg gcccctagct ctaagtctac tagcggcggc      420

accgccgctc tgggctgcct ggtgaaagac tacttccccg agcccgtgac cgtgtcatgg      480

aatagcggcg ctctgactag cggagtgcac accttccccg ccgtgctgca gtctagcggc      540

ctgtatagcc tgtctagcgt ggtgaccgtg cctagctcta gcctgggcac tcagacctac      600

atctgtaacg tgaaccacaa gccctctaac actaaggtgg acaagcgggt ggaacctaag      660

tcctgcgata agactcacac ctgtcccccc tgccctgccc ctgaggctgc cggaggacct      720

agcgtgttcc tgttcccacc taagcctaag gacaccctga tgatctctag gacccccgaa      780

gtgacctgcg tggtggtgga tgtgtctcac gaggaccctg aagtgaagtt caattggtac      840

gtggacggcg tggaagtgca caacgctaag actaagccta gagaggaaca gtataactcc      900

acctatagag tggtgtcagt gctgaccgtg ctgcatcagg actggctgaa cggcaaagag      960

tataagtgta aagtctctaa caaggccctg ccagccccta tcgaaaagac tatctctaag     1020

gctaagggcc agcctagaga acctcaggtg tacaccctgc ccccctgtag agaagagatg     1080

actaagaatc aggtgtccct gtggtgtctg gtgaaaggct tctaccctag cgatatcgcc     1140

gtggaatggg agtctaacgg ccagcccgag aacaactata agactacccc ccctgtgctg     1200

gatagcgacg gctcattctt cctgtactct aagctgaccg tggacaagtc taggtggcag     1260

cagggcaatg tgtttagctg tagcgtgatg cacgaggccc tgcataatca ctacactcag     1320

aagtcactga gcctgagccc cggcaag                                         1347


<210> 89
<211> 13
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 89
Ser Gly Ser Ser Ser Asn Ile Gly Asn His Tyr Val Asn 
1               5                   10              


<210> 90
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 90
Arg Asn Asn His Arg Pro Ser 
1               5           


<210> 91
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 91
Gln Ser Trp Asp Tyr Ser Gly Phe Ser Thr Val 
1               5                   10      


<210> 92
<211> 13
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 92
Ser Gly Ser Ser Ser Asn Ile Gly Asn His Tyr Val Asn 
1               5                   10              


<210> 93
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 93
Arg Asn Asn His Arg Pro Ser 
1               5           


<210> 94
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 94
Gln Ser Trp Asp Tyr Ser Gly Phe Ser Thr Val 
1               5                   10      


<210> 95
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 95
Ser Ser Ser Asn Ile Gly Asn His Tyr 
1               5                   


<210> 96
<211> 3
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 96
Arg Asn Asn 
1           


<210> 97
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 97
Trp Asp Tyr Ser Gly Phe Ser Thr 
1               5               


<210> 98
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 98
Ser Ser Asn Ile Gly Asn His Tyr 
1               5               


<210> 99
<211> 3
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 99
Arg Asn Asn 
1           


<210> 100
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 100
Gln Ser Trp Asp Tyr Ser Gly Phe Ser Thr Val 
1               5                   10      


<210> 101
<211> 110
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 101
Asp Ile Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn His 
            20                  25                  30          


Tyr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Arg Asn Asn His Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu Gln 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Trp Asp Tyr Ser Gly 
                85                  90                  95      


Phe Ser Thr Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110 


<210> 102
<211> 330
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 102
gatatcgtcc tgactcagcc ccctagcgtc agcggcgctc ccggtcagag agtgactatt       60

agctgtagcg gctctagctc taatatcggt aatcactacg tgaactggta tcagcagctg      120

cccggcaccg cccctaagct gctgatctat agaaacaatc accggcctag cggcgtgccc      180

gataggttta gcggatctaa gtcaggcact agcgctagtc tggctatcac cggactgcag      240

tcagaggacg aggccgacta ctactgtcag tcctgggact atagcggctt tagcaccgtg      300

ttcggcggag gcactaagct gaccgtgctg                                       330


<210> 103
<211> 216
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 103
Asp Ile Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn His 
            20                  25                  30          


Tyr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Arg Asn Asn His Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu Gln 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Trp Asp Tyr Ser Gly 
                85                  90                  95      


Phe Ser Thr Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln 
            100                 105                 110         


Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu 
        115                 120                 125             


Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr 
    130                 135                 140                 


Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys 
145                 150                 155                 160 


Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr 
                165                 170                 175     


Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His 
            180                 185                 190         


Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys 
        195                 200                 205             


Thr Val Ala Pro Thr Glu Cys Ser 
    210                 215     


<210> 104
<211> 648
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 104
gatatcgtcc tgactcagcc ccctagcgtc agcggcgctc ccggtcagag agtgactatt       60

agctgtagcg gctctagctc taatatcggt aatcactacg tgaactggta tcagcagctg      120

cccggcaccg cccctaagct gctgatctat agaaacaatc accggcctag cggcgtgccc      180

gataggttta gcggatctaa gtcaggcact agcgctagtc tggctatcac cggactgcag      240

tcagaggacg aggccgacta ctactgtcag tcctgggact atagcggctt tagcaccgtg      300

ttcggcggag gcactaagct gaccgtgctg ggtcagccta aggctgcccc cagcgtgacc      360

ctgttccccc ccagcagcga ggagctgcag gccaacaagg ccaccctggt gtgcctgatc      420

agcgacttct acccaggcgc cgtgaccgtg gcctggaagg ccgacagcag ccccgtgaag      480

gccggcgtgg agaccaccac ccccagcaag cagagcaaca acaagtacgc cgccagcagc      540

tacctgagcc tgacccccga gcagtggaag agccacaggt cctacagctg ccaggtgacc      600

cacgagggca gcaccgtgga aaagaccgtg gccccaaccg agtgcagc                   648


