                         SEQUENCE LISTING

<110>  AstraZeneca AB
 
<120>  NOVEL COMPOUNDS

<130>  200613-WO-PCT

<150>  62/519263
<151>  2017-06-14

<160>  2     

<170>  PatentIn version 3.5

<210>  1
<211>  526
<212>  PRT
<213>  Homo sapiens

<400>  1

His Asn His Asn His Asn His Asn His Asn His Asn Gly Gly Leu Asn 
1               5                   10                  15      


Asp Ile Phe Glu Ala Gln Lys Ile Glu Trp His Glu Gly Ser Pro Ile 
            20                  25                  30          


Leu Gly Tyr Trp Lys Ile Lys Gly Leu Val Gln Pro Thr Arg Leu Leu 
        35                  40                  45              


Leu Glu Tyr Leu Glu Glu Lys Tyr Glu Glu His Leu Tyr Glu Arg Asp 
    50                  55                  60                  


Glu Gly Asp Lys Trp Arg Asn Lys Lys Phe Glu Leu Gly Leu Glu Phe 
65                  70                  75                  80  


Pro Asn Leu Pro Tyr Tyr Ile Asp Gly Asp Val Lys Leu Thr Gln Ser 
                85                  90                  95      


Met Ala Ile Ile Arg Tyr Ile Ala Asp Lys His Asn Met Leu Gly Gly 
            100                 105                 110         


Cys Pro Lys Glu Arg Ala Glu Ile Ser Met Leu Glu Gly Ala Val Leu 
        115                 120                 125             


Asp Ile Arg Tyr Gly Val Ser Arg Ile Ala Tyr Ser Lys Asp Phe Glu 
    130                 135                 140                 


Thr Leu Lys Val Asp Phe Leu Ser Lys Leu Pro Glu Met Leu Lys Met 
145                 150                 155                 160 


Phe Glu Asp Arg Leu Cys His Lys Thr Tyr Leu Asn Gly Asp His Val 
                165                 170                 175     


Thr His Pro Asp Phe Met Leu Tyr Asp Ala Leu Asp Val Val Leu Tyr 
            180                 185                 190         


Met Asp Pro Met Cys Leu Asp Ala Phe Pro Lys Leu Val Cys Phe Lys 
        195                 200                 205             


Lys Arg Ile Glu Ala Ile Pro Gln Ile Asp Lys Tyr Leu Lys Ser Ser 
    210                 215                 220                 


Lys Tyr Ile Ala Trp Pro Leu Gln Gly Trp Gln Ala Thr Phe Gly Gly 
225                 230                 235                 240 


Gly Asp His Pro Pro Lys Ser Asp Tyr Asp Ile Pro Thr Thr Gly Ser 
                245                 250                 255     


Gly Ser Gly Ser Leu Val Pro Arg Gly Ser Thr Pro Glu Ala Pro Tyr 
            260                 265                 270         


Ala Ser Leu Thr Glu Ile Glu His Leu Val Gln Ser Val Cys Lys Ser 
        275                 280                 285             


Tyr Arg Glu Thr Cys Gln Leu Arg Leu Glu Asp Leu Leu Arg Gln Arg 
    290                 295                 300                 


Ser Asn Ile Phe Ser Arg Glu Glu Val Thr Gly Tyr Gln Arg Lys Ser 
305                 310                 315                 320 


Met Trp Glu Met Trp Glu Arg Cys Ala His His Leu Thr Glu Ala Ile 
                325                 330                 335     


Gln Tyr Val Val Glu Phe Ala Lys Arg Leu Ser Gly Phe Met Glu Leu 
            340                 345                 350         


Cys Gln Asn Asp Gln Ile Val Leu Leu Lys Ala Gly Ala Met Glu Val 
        355                 360                 365             


Val Leu Val Arg Met Cys Arg Ala Tyr Asn Ala Asp Asn Arg Thr Val 
    370                 375                 380                 


Phe Phe Glu Gly Lys Tyr Gly Gly Met Glu Leu Phe Arg Ala Leu Gly 
385                 390                 395                 400 


Cys Ser Glu Leu Ile Ser Ser Ile Phe Asp Phe Ser His Ser Leu Ser 
                405                 410                 415     


Ala Leu His Phe Ser Glu Asp Glu Ile Ala Leu Tyr Thr Ala Leu Val 
            420                 425                 430         


Leu Ile Asn Ala His Arg Pro Gly Leu Gln Glu Lys Arg Lys Val Glu 
        435                 440                 445             


Gln Leu Gln Tyr Asn Leu Glu Leu Ala Phe His His His Leu Cys Lys 
    450                 455                 460                 


Thr His Arg Gln Ser Ile Leu Ala Lys Leu Pro Pro Lys Gly Lys Leu 
465                 470                 475                 480 


Arg Ser Leu Cys Ser Gln His Val Glu Arg Leu Gln Ile Phe Gln His 
                485                 490                 495     


Leu His Pro Ile Val Val Gln Ala Ala Phe Pro Pro Leu Tyr Lys Glu 
            500                 505                 510         


Leu Phe Ser Thr Glu Thr Glu Ser Pro Val Gly Leu Ser Lys 
        515                 520                 525     


<210>  2
<211>  678
<212>  PRT
<213>  Homo sapiens

<400>  2

Met His Asn His Asn His Asn His Asn His Asn His Asn Gly Gly Leu 
1               5                   10                  15      


Asn Asp Ile Phe Glu Ala Gln Lys Ile Glu Trp His Glu Gly Met Lys 
            20                  25                  30          


Ile Glu Glu Gly Lys Leu Val Ile Trp Ile Asn Gly Asp Lys Gly Tyr 
        35                  40                  45              


Asn Gly Leu Ala Glu Val Gly Lys Lys Phe Glu Lys Asp Thr Gly Ile 
    50                  55                  60                  


Lys Val Thr Val Glu His Pro Asp Lys Leu Glu Glu Lys Phe Pro Gln 
65                  70                  75                  80  


Val Ala Ala Thr Gly Asp Gly Pro Asp Ile Ile Phe Trp Ala His Asp 
                85                  90                  95      


Arg Phe Gly Gly Tyr Ala Gln Ser Gly Leu Leu Ala Glu Ile Thr Pro 
            100                 105                 110         


Asp Lys Ala Phe Gln Asp Lys Leu Tyr Pro Phe Thr Trp Asp Ala Val 
        115                 120                 125             


Arg Tyr Asn Gly Lys Leu Ile Ala Tyr Pro Ile Ala Val Glu Ala Leu 
    130                 135                 140                 


Ser Leu Ile Tyr Asn Lys Asp Leu Leu Pro Asn Pro Pro Lys Thr Trp 
145                 150                 155                 160 


Glu Glu Ile Pro Ala Leu Asp Lys Glu Leu Lys Ala Lys Gly Lys Ser 
                165                 170                 175     


Ala Leu Met Phe Asn Leu Gln Glu Pro Tyr Phe Thr Trp Pro Leu Ile 
            180                 185                 190         


Ala Ala Asp Gly Gly Tyr Ala Phe Lys Tyr Glu Asn Gly Lys Tyr Asp 
        195                 200                 205             


Ile Lys Asp Val Gly Val Asp Asn Ala Gly Ala Lys Ala Gly Leu Thr 
    210                 215                 220                 


Phe Leu Val Asp Leu Ile Lys Asn Lys His Met Asn Ala Asp Thr Asp 
225                 230                 235                 240 


Tyr Ser Ile Ala Glu Ala Ala Phe Asn Lys Gly Glu Thr Ala Met Thr 
                245                 250                 255     


Ile Asn Gly Pro Trp Ala Trp Ser Asn Ile Asp Thr Ser Lys Val Asn 
            260                 265                 270         


Tyr Gly Val Thr Val Leu Pro Thr Phe Lys Gly Gln Pro Ser Lys Pro 
        275                 280                 285             


Phe Val Gly Val Leu Ser Ala Gly Ile Asn Ala Ala Ser Pro Asn Lys 
    290                 295                 300                 


Glu Leu Ala Lys Glu Phe Leu Glu Asn Tyr Leu Leu Thr Asp Glu Gly 
305                 310                 315                 320 


Leu Glu Ala Val Asn Lys Asp Lys Pro Leu Gly Ala Val Ala Leu Lys 
                325                 330                 335     


Ser Tyr Glu Glu Glu Leu Ala Lys Asp Pro Arg Ile Ala Ala Thr Met 
            340                 345                 350         


Glu Asn Ala Gln Lys Gly Glu Ile Met Pro Asn Ile Pro Gln Met Ser 
        355                 360                 365             


Ala Phe Trp Tyr Ala Val Arg Thr Ala Val Ile Asn Ala Ala Ser Gly 
    370                 375                 380                 


Arg Gln Thr Val Asp Glu Ala Leu Lys Asp Ala Gln Thr Gly Ser Asp 
385                 390                 395                 400 


Tyr Asp Ile Pro Thr Thr Gly Ser Gly Ser Gly Ser Leu Val Pro Arg 
                405                 410                 415     


Gly Ser Thr Pro Glu Ala Pro Tyr Ala Ser Leu Thr Glu Ile Glu His 
            420                 425                 430         


Leu Val Gln Ser Val Cys Lys Ser Tyr Arg Glu Thr Cys Gln Leu Arg 
        435                 440                 445             


Leu Glu Asp Leu Leu Arg Gln Arg Ser Asn Ile Phe Ser Arg Glu Glu 
    450                 455                 460                 


Val Thr Gly Tyr Gln Arg Lys Ser Met Trp Glu Met Trp Glu Arg Cys 
465                 470                 475                 480 


Ala His His Leu Thr Glu Ala Ile Gln Tyr Val Val Glu Phe Ala Lys 
                485                 490                 495     


Arg Leu Ser Gly Phe Met Glu Leu Cys Gln Asn Asp Gln Ile Val Leu 
            500                 505                 510         


Leu Lys Ala Gly Ala Met Glu Val Val Leu Val Arg Met Cys Arg Ala 
        515                 520                 525             


Tyr Asn Ala Asp Asn Arg Thr Val Phe Phe Glu Gly Lys Tyr Gly Gly 
    530                 535                 540                 


Met Glu Leu Phe Arg Ala Leu Gly Cys Ser Glu Leu Ile Ser Ser Ile 
545                 550                 555                 560 


Phe Asp Phe Ser His Ser Leu Ser Ala Leu His Phe Ser Glu Asp Glu 
                565                 570                 575     


Ile Ala Leu Tyr Thr Ala Leu Val Leu Ile Asn Ala His Arg Pro Gly 
            580                 585                 590         


Leu Gln Glu Lys Arg Lys Val Glu Gln Leu Gln Tyr Asn Leu Glu Leu 
        595                 600                 605             


Ala Phe His His His Leu Cys Lys Thr His Arg Gln Ser Ile Leu Ala 
    610                 615                 620                 


Lys Leu Pro Pro Lys Gly Lys Leu Arg Ser Leu Cys Ser Gln His Val 
625                 630                 635                 640 


Glu Arg Leu Gln Ile Phe Gln His Leu His Pro Ile Val Val Gln Ala 
                645                 650                 655     


Ala Phe Pro Pro Leu Tyr Lys Glu Leu Phe Ser Thr Glu Thr Glu Ser 
            660                 665                 670         


Pro Val Gly Leu Ser Lys 
        675             


