               SEQUENCE LISTING

<110> NESTEC SA

<120> MICRO-RNA BIOMARKERS OF BLOOD-BRAIN BARRIER DYSFUNCTION

<130> 15971

<160> 55

<170> BiSSAP 1.3.6

<210> 1
<211> 22
<212> RNA
<213> Homo sapiens


<220> 
<223> hsa-miR-204-5p

<400> 1
uucccuuugu cauccuaugc cu                                             22


<210> 2
<211> 22
<212> RNA
<213> Homo sapiens


<220> 
<223> hsa-miR-501-5p

<400> 2
aauccuuugu cccuggguga ga                                             22


<210> 3
<211> 22
<212> RNA
<213> Homo sapiens


<220> 
<223> hsa-miR-136-3p

<400> 3
caucaucguc ucaaaugagu cu                                             22


<210> 4
<211> 23
<212> RNA
<213> Homo sapiens


<220> 
<223> hsa-miR-34a-5p

<400> 4
uggcaggugu cuuagcuggu ugu                                            23


<210> 5
<211> 21
<212> RNA
<213> Homo sapiens


<220> 
<223> hsa-miR-6513-3p

<400> 5
ucaaguguca ucugucccua g                                              21


<210> 6
<211> 22
<212> RNA
<213> Homo sapiens


<220> 
<223> hsa-miR-624-5p

<400> 6
uaguaccagu accuuguguu ca                                             22


<210> 7
<211> 22
<212> RNA
<213> Homo sapiens


<220> 
<223> >hsa-miR-33a-3p

<400> 7
caauguuucc acagugcauc ac                                             22


<210> 8
<211> 21
<212> RNA
<213> Homo sapiens


<220> 
<223> hsa-miR-212-3p

<400> 8
uaacagucuc cagucacggc c                                              21


<210> 9
<211> 23
<212> RNA
<213> Homo sapiens


<220> 
<223> hsa-miR-6734-5p

<400> 9
uugaggggag aaugaggugg aga                                            23


<210> 10
<211> 22
<212> RNA
<213> Homo sapiens


<220> 
<223> hsa-miR-6723-5p

<400> 10
auaguccgag uaacgucggg gc                                             22


<210> 11
<211> 22
<212> RNA
<213> Homo sapiens


<220> 
<223> hsa-miR-3180-3p

<400> 11
uggggcggag cuuccggagg cc                                             22


<210> 12
<211> 22
<212> RNA
<213> Homo sapiens


<220> 
<223> hsa-miR-331-5p

<400> 12
cuagguaugg ucccagggau cc                                             22


<210> 13
<211> 21
<212> RNA
<213> Homo sapiens


<220> 
<223> hsa-miR-6747-3p

<400> 13
uccugccuuc cucugcacca g                                              21


<210> 14
<211> 22
<212> RNA
<213> Homo sapiens


<220> 
<223> hsa-miR-4798-5p

<400> 14
uucgguauac uuugugaauu gg                                             22


<210> 15
<211> 22
<212> RNA
<213> Homo sapiens


<220> 
<223> hsa-miR-5010-5p

<400> 15
agggggaugg cagagcaaaa uu                                             22


<210> 16
<211> 23
<212> RNA
<213> Homo sapiens


<220> 
<223> hsa-miR-500a-5p

<400> 16
uaauccuugc uaccugggug aga                                            23


<210> 17
<211> 22
<212> RNA
<213> Homo sapiens


<220> 
<223> hsa-miR-5010-3p

<400> 17
uuuugugucu cccauucccc ag                                             22


<210> 18
<211> 20
<212> RNA
<213> Homo sapiens


<220> 
<223> hsa-miR-4324

<400> 18
cccugagacc cuaaccuuaa                                                20


<210> 19
<211> 22
<212> RNA
<213> Homo sapiens


<220> 
<223> hsa-miR-16-1-3p

<400> 19
ccaguauuaa cugugcugcu ga                                             22


<210> 20
<211> 22
<212> RNA
<213> Homo sapiens


<220> 
<223> hsa-miR-885-3p

<400> 20
aggcagcggg guguagugga ua                                             22


<210> 21
<211> 23
<212> RNA
<213> Homo sapiens


<220> 
<223> hsa-miR-145-5p

<400> 21
guccaguuuu cccaggaauc ccu                                            23


<210> 22
<211> 22
<212> RNA
<213> Homo sapiens


<220> 
<223> hsa-miR-1247-5p

<400> 22
acccgucccg uucguccccg ga                                             22


<210> 23
<211> 24
<212> RNA
<213> Homo sapiens


<220> 
<223> hsa-miR-8089

<400> 23
ccuggggaca ggggauuggg gcag                                           24


<210> 24
<211> 18
<212> RNA
<213> Homo sapiens


<220> 
<223> hsa-miR-4292

<400> 24
ccccugggcc ggccuugg                                                  18


<210> 25
<211> 22
<212> RNA
<213> Homo sapiens


<220> 
<223> hsa-miR-6797-3p

<400> 25
ugcaugaccc uucccucccc ac                                             22


<210> 26
<211> 22
<212> RNA
<213> Homo sapiens


<220> 
<223> hsa-miR-4646-5p

<400> 26
acugggaaga ggagcugagg ga                                             22


<210> 27
<211> 21
<212> RNA
<213> Homo sapiens


<220> 
<223> hsa-miR-211-3p

<400> 27
gcagggacag caaaggggug c                                              21


<210> 28
<211> 21
<212> RNA
<213> Homo sapiens


<220> 
<223> hsa-miR-3124-5p

<400> 28
uucgcgggcg aaggcaaagu c                                              21


<210> 29
<211> 23
<212> RNA
<213> Homo sapiens


<220> 
<223> hsa-miR-8078

<400> 29
ggucuaggcc cggugagaga cuc                                            23


<210> 30
<211> 110
<212> RNA
<213> Homo sapiens


<220> 
<223> hsa-mir-204 MI0000284

<400> 30
ggcuacaguc uuucuucaug ugacucgugg acuucccuuu gucauccuau gccugagaau     60

auaugaagga ggcugggaag gcaaagggac guucaauugu caucacuggc               110


<210> 31
<211> 21
<212> RNA
<213> Homo sapiens


<220> 
<223> hsa-miR-204-3p MIMAT0022693

<400> 31
gcugggaagg caaagggacg u                                              21


<210> 32
<211> 84
<212> RNA
<213> Homo sapiens


<220> 
<223> hsa-mir-501 MI0003185

<400> 32
gcucuuccuc ucuaauccuu ugucccuggg ugagagugcu uucugaaugc aaugcacccg     60

ggcaaggauu cugagagggu gagc                                            84


<210> 33
<211> 22
<212> RNA
<213> Homo sapiens


<220> 
<223> hsa-miR-501-3p MIMAT0004774

<400> 33
aaugcacccg ggcaaggauu cu                                             22


<210> 34
<211> 82
<212> RNA
<213> Homo sapiens


<220> 
<223> hsa-mir-136 MI0000475

<400> 34
ugagcccucg gaggacucca uuuguuuuga ugauggauuc uuaugcucca ucaucgucuc     60

aaaugagucu ucagaggguu cu                                              82


<210> 35
<211> 23
<212> RNA
<213> Homo sapiens


<220> 
<223> hsa-miR-136-5p MIMAT0000448

<400> 35
acuccauuug uuuugaugau gga                                            23


<210> 36
<211> 110
<212> RNA
<213> Homo sapiens


<220> 
<223> hsa-mir-34a MI0000268

<400> 36
ggccagcugu gaguguuucu uuggcagugu cuuagcuggu uguugugagc aauaguaagg     60

aagcaaucag caaguauacu gcccuagaag ugcugcacgu uguggggccc               110


<210> 37
<211> 22
<212> RNA
<213> Homo sapiens


<220> 
<223> hsa-miR-34a-3p MIMAT0004557

<400> 37
caaucagcaa guauacugcc cu                                             22


<210> 38
<211> 840
<212> PRT
<213> Homo sapiens


<400> 38
Met Ser Ala Phe Arg Leu Trp Pro Gly Leu Leu Ile Met Leu Gly Ser 
1               5                   10                  15      
Leu Cys His Arg Gly Ser Pro Cys Gly Leu Ser Thr His Val Glu Ile 
            20                  25                  30          
Gly His Arg Ala Leu Glu Phe Leu Gln Leu His Asn Gly Arg Val Asn 
        35                  40                  45              
Tyr Arg Glu Leu Leu Leu Glu His Gln Asp Ala Tyr Gln Ala Gly Ile 
    50                  55                  60                  
Val Phe Pro Asp Cys Phe Tyr Pro Ser Ile Cys Lys Gly Gly Lys Phe 
65                  70                  75                  80  
His Asp Val Ser Glu Ser Thr His Trp Thr Pro Phe Leu Asn Ala Ser 
                85                  90                  95      
Val His Tyr Ile Arg Glu Asn Tyr Pro Leu Pro Trp Glu Lys Asp Thr 
            100                 105                 110         
Glu Lys Leu Val Ala Phe Leu Phe Gly Ile Thr Ser His Met Ala Ala 
        115                 120                 125             
Asp Val Ser Trp His Ser Leu Gly Leu Glu Gln Gly Phe Leu Arg Thr 
    130                 135                 140                 
Met Gly Ala Ile Asp Phe His Gly Ser Tyr Ser Glu Ala His Ser Ala 
145                 150                 155                 160 
Gly Asp Phe Gly Gly Asp Val Leu Ser Gln Phe Glu Phe Asn Phe Asn 
                165                 170                 175     
Tyr Leu Ala Arg Arg Trp Tyr Val Pro Val Lys Asp Leu Leu Gly Ile 
            180                 185                 190         
Tyr Glu Lys Leu Tyr Gly Arg Lys Val Ile Thr Glu Asn Val Ile Val 
        195                 200                 205             
Asp Cys Ser His Ile Gln Phe Leu Glu Met Tyr Gly Glu Met Leu Ala 
    210                 215                 220                 
Val Ser Lys Leu Tyr Pro Thr Tyr Ser Thr Lys Ser Pro Phe Leu Val 
225                 230                 235                 240 
Glu Gln Phe Gln Glu Tyr Phe Leu Gly Gly Leu Asp Asp Met Ala Phe 
                245                 250                 255     
Trp Ser Thr Asn Ile Tyr His Leu Thr Ser Phe Met Leu Glu Asn Gly 
            260                 265                 270         
Thr Ser Asp Cys Asn Leu Pro Glu Asn Pro Leu Phe Ile Ala Cys Gly 
        275                 280                 285             
Gly Gln Gln Asn His Thr Gln Gly Ser Lys Met Gln Lys Asn Asp Phe 
    290                 295                 300                 
His Arg Asn Leu Thr Thr Ser Leu Thr Glu Ser Val Asp Arg Asn Ile 
305                 310                 315                 320 
Asn Tyr Thr Glu Arg Gly Val Phe Phe Ser Val Asn Ser Trp Thr Pro 
                325                 330                 335     
Asp Ser Met Ser Phe Ile Tyr Lys Ala Leu Glu Arg Asn Ile Arg Thr 
            340                 345                 350         
Met Phe Ile Gly Gly Ser Gln Leu Ser Gln Lys His Val Ser Ser Pro 
        355                 360                 365             
Leu Ala Ser Tyr Phe Leu Ser Phe Pro Tyr Ala Arg Leu Gly Trp Ala 
    370                 375                 380                 
Met Thr Ser Ala Asp Leu Asn Gln Asp Gly His Gly Asp Leu Val Val 
385                 390                 395                 400 
Gly Ala Pro Gly Tyr Ser Arg Pro Gly His Ile His Ile Gly Arg Val 
                405                 410                 415     
Tyr Leu Ile Tyr Gly Asn Asp Leu Gly Leu Pro Pro Val Asp Leu Asp 
            420                 425                 430         
Leu Asp Lys Glu Ala His Arg Ile Leu Glu Gly Phe Gln Pro Ser Gly 
        435                 440                 445             
Arg Phe Gly Ser Ala Leu Ala Val Leu Asp Phe Asn Val Asp Gly Val 
    450                 455                 460                 
Pro Asp Leu Ala Val Gly Ala Pro Ser Val Gly Ser Glu Gln Leu Thr 
465                 470                 475                 480 
Tyr Lys Gly Ala Val Tyr Val Tyr Phe Gly Ser Lys Gln Gly Gly Met 
                485                 490                 495     
Ser Ser Ser Pro Asn Ile Thr Ile Ser Cys Gln Asp Ile Tyr Cys Asn 
            500                 505                 510         
Leu Gly Trp Thr Leu Leu Ala Ala Asp Val Asn Gly Asp Ser Glu Pro 
        515                 520                 525             
Asp Leu Val Ile Gly Ser Pro Phe Ala Pro Gly Gly Gly Lys Gln Lys 
    530                 535                 540                 
Gly Ile Val Ala Ala Phe Tyr Ser Gly Pro Ser Leu Ser Asp Lys Glu 
545                 550                 555                 560 
Lys Leu Asn Val Glu Ala Ala Asn Trp Thr Val Arg Gly Glu Glu Asp 
                565                 570                 575     
Phe Ser Trp Phe Gly Tyr Ser Leu His Gly Val Thr Val Asp Asn Arg 
            580                 585                 590         
Thr Leu Leu Leu Val Gly Ser Pro Thr Trp Lys Asn Ala Ser Arg Leu 
        595                 600                 605             
Gly His Leu Leu His Ile Arg Asp Glu Lys Lys Ser Leu Gly Arg Val 
    610                 615                 620                 
Tyr Gly Tyr Phe Pro Pro Asn Gly Gln Ser Trp Phe Thr Ile Ser Gly 
625                 630                 635                 640 
Asp Lys Ala Met Gly Lys Leu Gly Thr Ser Leu Ser Ser Gly His Val 
                645                 650                 655     
Leu Met Asn Gly Thr Leu Lys Gln Val Leu Leu Val Gly Ala Pro Thr 
            660                 665                 670         
Tyr Asp Asp Val Ser Lys Val Ala Phe Leu Thr Val Thr Leu His Gln 
        675                 680                 685             
Gly Gly Ala Thr Arg Met Tyr Ala Leu Thr Ser Asp Ala Gln Pro Leu 
    690                 695                 700                 
Leu Leu Ser Thr Phe Ser Gly Asp Arg Arg Phe Ser Arg Phe Gly Gly 
705                 710                 715                 720 
Val Leu His Leu Ser Asp Leu Asp Asp Asp Gly Leu Asp Glu Ile Ile 
                725                 730                 735     
Met Ala Ala Pro Leu Arg Ile Ala Asp Val Thr Ser Gly Leu Ile Gly 
            740                 745                 750         
Gly Glu Asp Gly Arg Val Tyr Val Tyr Asn Gly Lys Glu Thr Thr Leu 
        755                 760                 765             
Gly Asp Met Thr Gly Lys Cys Lys Ser Trp Ile Thr Pro Cys Pro Glu 
    770                 775                 780                 
Glu Lys Ala Gln Tyr Val Leu Ile Ser Pro Glu Ala Ser Ser Arg Phe 
785                 790                 795                 800 
Gly Ser Ser Leu Ile Thr Val Arg Ser Lys Ala Lys Asn Gln Val Val 
                805                 810                 815     
Ile Ala Ala Gly Arg Ser Ser Leu Gly Ala Arg Leu Ser Gly Ala Leu 
            820                 825                 830         
His Val Tyr Ser Leu Gly Ser Asp 
        835                 840 

<210> 39
<211> 817
<212> PRT
<213> Homo sapiens


<220> 
<223> PHLD mature form cleaved from original peptide

<400> 39
Cys Gly Leu Ser Thr His Val Glu Ile Gly His Arg Ala Leu Glu Phe 
1               5                   10                  15      
Leu Gln Leu His Asn Gly Arg Val Asn Tyr Arg Glu Leu Leu Leu Glu 
            20                  25                  30          
His Gln Asp Ala Tyr Gln Ala Gly Ile Val Phe Pro Asp Cys Phe Tyr 
        35                  40                  45              
Pro Ser Ile Cys Lys Gly Gly Lys Phe His Asp Val Ser Glu Ser Thr 
    50                  55                  60                  
His Trp Thr Pro Phe Leu Asn Ala Ser Val His Tyr Ile Arg Glu Asn 
65                  70                  75                  80  
Tyr Pro Leu Pro Trp Glu Lys Asp Thr Glu Lys Leu Val Ala Phe Leu 
                85                  90                  95      
Phe Gly Ile Thr Ser His Met Ala Ala Asp Val Ser Trp His Ser Leu 
            100                 105                 110         
Gly Leu Glu Gln Gly Phe Leu Arg Thr Met Gly Ala Ile Asp Phe His 
        115                 120                 125             
Gly Ser Tyr Ser Glu Ala His Ser Ala Gly Asp Phe Gly Gly Asp Val 
    130                 135                 140                 
Leu Ser Gln Phe Glu Phe Asn Phe Asn Tyr Leu Ala Arg Arg Trp Tyr 
145                 150                 155                 160 
Val Pro Val Lys Asp Leu Leu Gly Ile Tyr Glu Lys Leu Tyr Gly Arg 
                165                 170                 175     
Lys Val Ile Thr Glu Asn Val Ile Val Asp Cys Ser His Ile Gln Phe 
            180                 185                 190         
Leu Glu Met Tyr Gly Glu Met Leu Ala Val Ser Lys Leu Tyr Pro Thr 
        195                 200                 205             
Tyr Ser Thr Lys Ser Pro Phe Leu Val Glu Gln Phe Gln Glu Tyr Phe 
    210                 215                 220                 
Leu Gly Gly Leu Asp Asp Met Ala Phe Trp Ser Thr Asn Ile Tyr His 
225                 230                 235                 240 
Leu Thr Ser Phe Met Leu Glu Asn Gly Thr Ser Asp Cys Asn Leu Pro 
                245                 250                 255     
Glu Asn Pro Leu Phe Ile Ala Cys Gly Gly Gln Gln Asn His Thr Gln 
            260                 265                 270         
Gly Ser Lys Met Gln Lys Asn Asp Phe His Arg Asn Leu Thr Thr Ser 
        275                 280                 285             
Leu Thr Glu Ser Val Asp Arg Asn Ile Asn Tyr Thr Glu Arg Gly Val 
    290                 295                 300                 
Phe Phe Ser Val Asn Ser Trp Thr Pro Asp Ser Met Ser Phe Ile Tyr 
305                 310                 315                 320 
Lys Ala Leu Glu Arg Asn Ile Arg Thr Met Phe Ile Gly Gly Ser Gln 
                325                 330                 335     
Leu Ser Gln Lys His Val Ser Ser Pro Leu Ala Ser Tyr Phe Leu Ser 
            340                 345                 350         
Phe Pro Tyr Ala Arg Leu Gly Trp Ala Met Thr Ser Ala Asp Leu Asn 
        355                 360                 365             
Gln Asp Gly His Gly Asp Leu Val Val Gly Ala Pro Gly Tyr Ser Arg 
    370                 375                 380                 
Pro Gly His Ile His Ile Gly Arg Val Tyr Leu Ile Tyr Gly Asn Asp 
385                 390                 395                 400 
Leu Gly Leu Pro Pro Val Asp Leu Asp Leu Asp Lys Glu Ala His Arg 
                405                 410                 415     
Ile Leu Glu Gly Phe Gln Pro Ser Gly Arg Phe Gly Ser Ala Leu Ala 
            420                 425                 430         
Val Leu Asp Phe Asn Val Asp Gly Val Pro Asp Leu Ala Val Gly Ala 
        435                 440                 445             
Pro Ser Val Gly Ser Glu Gln Leu Thr Tyr Lys Gly Ala Val Tyr Val 
    450                 455                 460                 
Tyr Phe Gly Ser Lys Gln Gly Gly Met Ser Ser Ser Pro Asn Ile Thr 
465                 470                 475                 480 
Ile Ser Cys Gln Asp Ile Tyr Cys Asn Leu Gly Trp Thr Leu Leu Ala 
                485                 490                 495     
Ala Asp Val Asn Gly Asp Ser Glu Pro Asp Leu Val Ile Gly Ser Pro 
            500                 505                 510         
Phe Ala Pro Gly Gly Gly Lys Gln Lys Gly Ile Val Ala Ala Phe Tyr 
        515                 520                 525             
Ser Gly Pro Ser Leu Ser Asp Lys Glu Lys Leu Asn Val Glu Ala Ala 
    530                 535                 540                 
Asn Trp Thr Val Arg Gly Glu Glu Asp Phe Ser Trp Phe Gly Tyr Ser 
545                 550                 555                 560 
Leu His Gly Val Thr Val Asp Asn Arg Thr Leu Leu Leu Val Gly Ser 
                565                 570                 575     
Pro Thr Trp Lys Asn Ala Ser Arg Leu Gly His Leu Leu His Ile Arg 
            580                 585                 590         
Asp Glu Lys Lys Ser Leu Gly Arg Val Tyr Gly Tyr Phe Pro Pro Asn 
        595                 600                 605             
Gly Gln Ser Trp Phe Thr Ile Ser Gly Asp Lys Ala Met Gly Lys Leu 
    610                 615                 620                 
Gly Thr Ser Leu Ser Ser Gly His Val Leu Met Asn Gly Thr Leu Lys 
625                 630                 635                 640 
Gln Val Leu Leu Val Gly Ala Pro Thr Tyr Asp Asp Val Ser Lys Val 
                645                 650                 655     
Ala Phe Leu Thr Val Thr Leu His Gln Gly Gly Ala Thr Arg Met Tyr 
            660                 665                 670         
Ala Leu Thr Ser Asp Ala Gln Pro Leu Leu Leu Ser Thr Phe Ser Gly 
        675                 680                 685             
Asp Arg Arg Phe Ser Arg Phe Gly Gly Val Leu His Leu Ser Asp Leu 
    690                 695                 700                 
Asp Asp Asp Gly Leu Asp Glu Ile Ile Met Ala Ala Pro Leu Arg Ile 
705                 710                 715                 720 
Ala Asp Val Thr Ser Gly Leu Ile Gly Gly Glu Asp Gly Arg Val Tyr 
                725                 730                 735     
Val Tyr Asn Gly Lys Glu Thr Thr Leu Gly Asp Met Thr Gly Lys Cys 
            740                 745                 750         
Lys Ser Trp Ile Thr Pro Cys Pro Glu Glu Lys Ala Gln Tyr Val Leu 
        755                 760                 765             
Ile Ser Pro Glu Ala Ser Ser Arg Phe Gly Ser Ser Leu Ile Thr Val 
    770                 775                 780                 
Arg Ser Lys Ala Lys Asn Gln Val Val Ile Ala Ala Gly Arg Ser Ser 
785                 790                 795                 800 
Leu Gly Ala Arg Leu Ser Gly Ala Leu His Val Tyr Ser Leu Gly Ser 
                805                 810                 815     
Asp 
    

<210> 40
<211> 176
<212> PRT
<213> Homo sapiens


<220> 
<223> PHLD isoform 2

<400> 40
Met Ser Ala Phe Arg Leu Trp Pro Gly Leu Leu Ile Met Leu Gly Ser 
1               5                   10                  15      
Leu Cys His Arg Gly Ser Pro Cys Gly Leu Ser Thr His Val Glu Ile 
            20                  25                  30          
Gly His Arg Ala Leu Glu Phe Leu Gln Leu His Asn Gly Arg Val Asn 
        35                  40                  45              
Tyr Arg Glu Leu Leu Leu Glu His Gln Asp Ala Tyr Gln Ala Gly Ile 
    50                  55                  60                  
Val Phe Pro Asp Cys Phe Tyr Pro Ser Ile Cys Lys Gly Gly Lys Phe 
65                  70                  75                  80  
His Asp Val Ser Glu Ser Thr His Trp Thr Pro Phe Leu Asn Ala Ser 
                85                  90                  95      
Val His Tyr Ile Arg Glu Asn Tyr Pro Leu Pro Trp Glu Lys Asp Thr 
            100                 105                 110         
Glu Lys Leu Val Ala Phe Leu Phe Gly Ile Thr Ser His Met Ala Ala 
        115                 120                 125             
Asp Val Ser Trp His Ser Leu Gly Leu Glu Gln Gly Phe Leu Arg Thr 
    130                 135                 140                 
Met Gly Ala Ile Asp Phe His Gly Ser Tyr Ser Glu Ala His Ser Ala 
145                 150                 155                 160 
Gly Asp Phe Gly Thr Val Tyr Leu His Leu Leu Asn Phe Leu Val Val 
                165                 170                 175     



<210> 41
<211> 1404
<212> PRT
<213> Homo sapiens


<220> 
<223> PRG4

<400> 41
Met Ala Trp Lys Thr Leu Pro Ile Tyr Leu Leu Leu Leu Leu Ser Val 
1               5                   10                  15      
Phe Val Ile Gln Gln Val Ser Ser Gln Asp Leu Ser Ser Cys Ala Gly 
            20                  25                  30          
Arg Cys Gly Glu Gly Tyr Ser Arg Asp Ala Thr Cys Asn Cys Asp Tyr 
        35                  40                  45              
Asn Cys Gln His Tyr Met Glu Cys Cys Pro Asp Phe Lys Arg Val Cys 
    50                  55                  60                  
Thr Ala Glu Leu Ser Cys Lys Gly Arg Cys Phe Glu Ser Phe Glu Arg 
65                  70                  75                  80  
Gly Arg Glu Cys Asp Cys Asp Ala Gln Cys Lys Lys Tyr Asp Lys Cys 
                85                  90                  95      
Cys Pro Asp Tyr Glu Ser Phe Cys Ala Glu Val His Asn Pro Thr Ser 
            100                 105                 110         
Pro Pro Ser Ser Lys Lys Ala Pro Pro Pro Ser Gly Ala Ser Gln Thr 
        115                 120                 125             
Ile Lys Ser Thr Thr Lys Arg Ser Pro Lys Pro Pro Asn Lys Lys Lys 
    130                 135                 140                 
Thr Lys Lys Val Ile Glu Ser Glu Glu Ile Thr Glu Glu His Ser Val 
145                 150                 155                 160 
Ser Glu Asn Gln Glu Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser 
                165                 170                 175     
Ser Thr Ile Arg Lys Ile Lys Ser Ser Lys Asn Ser Ala Ala Asn Arg 
            180                 185                 190         
Glu Leu Gln Lys Lys Leu Lys Val Lys Asp Asn Lys Lys Asn Arg Thr 
        195                 200                 205             
Lys Lys Lys Pro Thr Pro Lys Pro Pro Val Val Asp Glu Ala Gly Ser 
    210                 215                 220                 
Gly Leu Asp Asn Gly Asp Phe Lys Val Thr Thr Pro Asp Thr Ser Thr 
225                 230                 235                 240 
Thr Gln His Asn Lys Val Ser Thr Ser Pro Lys Ile Thr Thr Ala Lys 
                245                 250                 255     
Pro Ile Asn Pro Arg Pro Ser Leu Pro Pro Asn Ser Asp Thr Ser Lys 
            260                 265                 270         
Glu Thr Ser Leu Thr Val Asn Lys Glu Thr Thr Val Glu Thr Lys Glu 
        275                 280                 285             
Thr Thr Thr Thr Asn Lys Gln Thr Ser Thr Asp Gly Lys Glu Lys Thr 
    290                 295                 300                 
Thr Ser Ala Lys Glu Thr Gln Ser Ile Glu Lys Thr Ser Ala Lys Asp 
305                 310                 315                 320 
Leu Ala Pro Thr Ser Lys Val Leu Ala Lys Pro Thr Pro Lys Ala Glu 
                325                 330                 335     
Thr Thr Thr Lys Gly Pro Ala Leu Thr Thr Pro Lys Glu Pro Thr Pro 
            340                 345                 350         
Thr Thr Pro Lys Glu Pro Ala Ser Thr Thr Pro Lys Glu Pro Thr Pro 
        355                 360                 365             
Thr Thr Ile Lys Ser Ala Pro Thr Thr Pro Lys Glu Pro Ala Pro Thr 
    370                 375                 380                 
Thr Thr Lys Ser Ala Pro Thr Thr Pro Lys Glu Pro Ala Pro Thr Thr 
385                 390                 395                 400 
Thr Lys Glu Pro Ala Pro Thr Thr Pro Lys Glu Pro Ala Pro Thr Thr 
                405                 410                 415     
Thr Lys Glu Pro Ala Pro Thr Thr Thr Lys Ser Ala Pro Thr Thr Pro 
            420                 425                 430         
Lys Glu Pro Ala Pro Thr Thr Pro Lys Lys Pro Ala Pro Thr Thr Pro 
        435                 440                 445             
Lys Glu Pro Ala Pro Thr Thr Pro Lys Glu Pro Thr Pro Thr Thr Pro 
    450                 455                 460                 
Lys Glu Pro Ala Pro Thr Thr Lys Glu Pro Ala Pro Thr Thr Pro Lys 
465                 470                 475                 480 
Glu Pro Ala Pro Thr Ala Pro Lys Lys Pro Ala Pro Thr Thr Pro Lys 
                485                 490                 495     
Glu Pro Ala Pro Thr Thr Pro Lys Glu Pro Ala Pro Thr Thr Thr Lys 
            500                 505                 510         
Glu Pro Ser Pro Thr Thr Pro Lys Glu Pro Ala Pro Thr Thr Thr Lys 
        515                 520                 525             
Ser Ala Pro Thr Thr Thr Lys Glu Pro Ala Pro Thr Thr Thr Lys Ser 
    530                 535                 540                 
Ala Pro Thr Thr Pro Lys Glu Pro Ser Pro Thr Thr Thr Lys Glu Pro 
545                 550                 555                 560 
Ala Pro Thr Thr Pro Lys Glu Pro Ala Pro Thr Thr Pro Lys Lys Pro 
                565                 570                 575     
Ala Pro Thr Thr Pro Lys Glu Pro Ala Pro Thr Thr Pro Lys Glu Pro 
            580                 585                 590         
Ala Pro Thr Thr Thr Lys Lys Pro Ala Pro Thr Thr Pro Lys Glu Pro 
        595                 600                 605             
Ala Pro Thr Thr Pro Lys Glu Thr Ala Pro Thr Thr Pro Lys Lys Leu 
    610                 615                 620                 
Thr Pro Thr Thr Pro Glu Lys Leu Ala Pro Thr Thr Pro Glu Lys Pro 
625                 630                 635                 640 
Ala Pro Thr Thr Pro Glu Glu Leu Ala Pro Thr Thr Pro Glu Glu Pro 
                645                 650                 655     
Thr Pro Thr Thr Pro Glu Glu Pro Ala Pro Thr Thr Pro Lys Ala Ala 
            660                 665                 670         
Ala Pro Asn Thr Pro Lys Glu Pro Ala Pro Thr Thr Pro Lys Glu Pro 
        675                 680                 685             
Ala Pro Thr Thr Pro Lys Glu Pro Ala Pro Thr Thr Pro Lys Glu Thr 
    690                 695                 700                 
Ala Pro Thr Thr Pro Lys Gly Thr Ala Pro Thr Thr Leu Lys Glu Pro 
705                 710                 715                 720 
Ala Pro Thr Thr Pro Lys Lys Pro Ala Pro Lys Glu Leu Ala Pro Thr 
                725                 730                 735     
Thr Thr Lys Glu Pro Thr Ser Thr Thr Cys Asp Lys Pro Ala Pro Thr 
            740                 745                 750         
Thr Pro Lys Gly Thr Ala Pro Thr Thr Pro Lys Glu Pro Ala Pro Thr 
        755                 760                 765             
Thr Pro Lys Glu Pro Ala Pro Thr Thr Pro Lys Gly Thr Ala Pro Thr 
    770                 775                 780                 
Thr Leu Lys Glu Pro Ala Pro Thr Thr Pro Lys Lys Pro Ala Pro Lys 
785                 790                 795                 800 
Glu Leu Ala Pro Thr Thr Thr Lys Gly Pro Thr Ser Thr Thr Ser Asp 
                805                 810                 815     
Lys Pro Ala Pro Thr Thr Pro Lys Glu Thr Ala Pro Thr Thr Pro Lys 
            820                 825                 830         
Glu Pro Ala Pro Thr Thr Pro Lys Lys Pro Ala Pro Thr Thr Pro Glu 
        835                 840                 845             
Thr Pro Pro Pro Thr Thr Ser Glu Val Ser Thr Pro Thr Thr Thr Lys 
    850                 855                 860                 
Glu Pro Thr Thr Ile His Lys Ser Pro Asp Glu Ser Thr Pro Glu Leu 
865                 870                 875                 880 
Ser Ala Glu Pro Thr Pro Lys Ala Leu Glu Asn Ser Pro Lys Glu Pro 
                885                 890                 895     
Gly Val Pro Thr Thr Lys Thr Pro Ala Ala Thr Lys Pro Glu Met Thr 
            900                 905                 910         
Thr Thr Ala Lys Asp Lys Thr Thr Glu Arg Asp Leu Arg Thr Thr Pro 
        915                 920                 925             
Glu Thr Thr Thr Ala Ala Pro Lys Met Thr Lys Glu Thr Ala Thr Thr 
    930                 935                 940                 
Thr Glu Lys Thr Thr Glu Ser Lys Ile Thr Ala Thr Thr Thr Gln Val 
945                 950                 955                 960 
Thr Ser Thr Thr Thr Gln Asp Thr Thr Pro Phe Lys Ile Thr Thr Leu 
                965                 970                 975     
Lys Thr Thr Thr Leu Ala Pro Lys Val Thr Thr Thr Lys Lys Thr Ile 
            980                 985                 990         
Thr Thr Thr Glu Ile Met Asn Lys Pro Glu Glu Thr Ala Lys Pro Lys 
        995                 1000                1005            
Asp Arg Ala Thr Asn Ser Lys Ala Thr Thr Pro Lys Pro Gln Lys Pro 
    1010                1015                1020                
Thr Lys Ala Pro Lys Lys Pro Thr Ser Thr Lys Lys Pro Lys Thr Met 
1025                1030                1035                1040
Pro Arg Val Arg Lys Pro Lys Thr Thr Pro Thr Pro Arg Lys Met Thr 
                1045                1050                1055    
Ser Thr Met Pro Glu Leu Asn Pro Thr Ser Arg Ile Ala Glu Ala Met 
            1060                1065                1070        
Leu Gln Thr Thr Thr Arg Pro Asn Gln Thr Pro Asn Ser Lys Leu Val 
        1075                1080                1085            
Glu Val Asn Pro Lys Ser Glu Asp Ala Gly Gly Ala Glu Gly Glu Thr 
    1090                1095                1100                
Pro His Met Leu Leu Arg Pro His Val Phe Met Pro Glu Val Thr Pro 
1105                1110                1115                1120
Asp Met Asp Tyr Leu Pro Arg Val Pro Asn Gln Gly Ile Ile Ile Asn 
                1125                1130                1135    
Pro Met Leu Ser Asp Glu Thr Asn Ile Cys Asn Gly Lys Pro Val Asp 
            1140                1145                1150        
Gly Leu Thr Thr Leu Arg Asn Gly Thr Leu Val Ala Phe Arg Gly His 
        1155                1160                1165            
Tyr Phe Trp Met Leu Ser Pro Phe Ser Pro Pro Ser Pro Ala Arg Arg 
    1170                1175                1180                
Ile Thr Glu Val Trp Gly Ile Pro Ser Pro Ile Asp Thr Val Phe Thr 
1185                1190                1195                1200
Arg Cys Asn Cys Glu Gly Lys Thr Phe Phe Phe Lys Asp Ser Gln Tyr 
                1205                1210                1215    
Trp Arg Phe Thr Asn Asp Ile Lys Asp Ala Gly Tyr Pro Lys Pro Ile 
            1220                1225                1230        
Phe Lys Gly Phe Gly Gly Leu Thr Gly Gln Ile Val Ala Ala Leu Ser 
        1235                1240                1245            
Thr Ala Lys Tyr Lys Asn Trp Pro Glu Ser Val Tyr Phe Phe Lys Arg 
    1250                1255                1260                
Gly Gly Ser Ile Gln Gln Tyr Ile Tyr Lys Gln Glu Pro Val Gln Lys 
1265                1270                1275                1280
Cys Pro Gly Arg Arg Pro Ala Leu Asn Tyr Pro Val Tyr Gly Glu Thr 
                1285                1290                1295    
Thr Gln Val Arg Arg Arg Arg Phe Glu Arg Ala Ile Gly Pro Ser Gln 
            1300                1305                1310        
Thr His Thr Ile Arg Ile Gln Tyr Ser Pro Ala Arg Leu Ala Tyr Gln 
        1315                1320                1325            
Asp Lys Gly Val Leu His Asn Glu Val Lys Val Ser Ile Leu Trp Arg 
    1330                1335                1340                
Gly Leu Pro Asn Val Val Thr Ser Ala Ile Ser Leu Pro Asn Ile Arg 
1345                1350                1355                1360
Lys Pro Asp Gly Tyr Asp Tyr Tyr Ala Phe Ser Lys Asp Gln Tyr Tyr 
                1365                1370                1375    
Asn Ile Asp Val Pro Ser Arg Thr Ala Arg Ala Ile Thr Thr Arg Ser 
            1380                1385                1390        
Gly Gln Thr Leu Ser Lys Val Trp Tyr Asn Cys Pro 
        1395                1400                

<210> 42
<211> 1380
<212> PRT
<213> Homo sapiens


<220> 
<223> PRG4 - mature form

<400> 42
Gln Asp Leu Ser Ser Cys Ala Gly Arg Cys Gly Glu Gly Tyr Ser Arg 
1               5                   10                  15      
Asp Ala Thr Cys Asn Cys Asp Tyr Asn Cys Gln His Tyr Met Glu Cys 
            20                  25                  30          
Cys Pro Asp Phe Lys Arg Val Cys Thr Ala Glu Leu Ser Cys Lys Gly 
        35                  40                  45              
Arg Cys Phe Glu Ser Phe Glu Arg Gly Arg Glu Cys Asp Cys Asp Ala 
    50                  55                  60                  
Gln Cys Lys Lys Tyr Asp Lys Cys Cys Pro Asp Tyr Glu Ser Phe Cys 
65                  70                  75                  80  
Ala Glu Val His Asn Pro Thr Ser Pro Pro Ser Ser Lys Lys Ala Pro 
                85                  90                  95      
Pro Pro Ser Gly Ala Ser Gln Thr Ile Lys Ser Thr Thr Lys Arg Ser 
            100                 105                 110         
Pro Lys Pro Pro Asn Lys Lys Lys Thr Lys Lys Val Ile Glu Ser Glu 
        115                 120                 125             
Glu Ile Thr Glu Glu His Ser Val Ser Glu Asn Gln Glu Ser Ser Ser 
    130                 135                 140                 
Ser Ser Ser Ser Ser Ser Ser Ser Ser Thr Ile Arg Lys Ile Lys Ser 
145                 150                 155                 160 
Ser Lys Asn Ser Ala Ala Asn Arg Glu Leu Gln Lys Lys Leu Lys Val 
                165                 170                 175     
Lys Asp Asn Lys Lys Asn Arg Thr Lys Lys Lys Pro Thr Pro Lys Pro 
            180                 185                 190         
Pro Val Val Asp Glu Ala Gly Ser Gly Leu Asp Asn Gly Asp Phe Lys 
        195                 200                 205             
Val Thr Thr Pro Asp Thr Ser Thr Thr Gln His Asn Lys Val Ser Thr 
    210                 215                 220                 
Ser Pro Lys Ile Thr Thr Ala Lys Pro Ile Asn Pro Arg Pro Ser Leu 
225                 230                 235                 240 
Pro Pro Asn Ser Asp Thr Ser Lys Glu Thr Ser Leu Thr Val Asn Lys 
                245                 250                 255     
Glu Thr Thr Val Glu Thr Lys Glu Thr Thr Thr Thr Asn Lys Gln Thr 
            260                 265                 270         
Ser Thr Asp Gly Lys Glu Lys Thr Thr Ser Ala Lys Glu Thr Gln Ser 
        275                 280                 285             
Ile Glu Lys Thr Ser Ala Lys Asp Leu Ala Pro Thr Ser Lys Val Leu 
    290                 295                 300                 
Ala Lys Pro Thr Pro Lys Ala Glu Thr Thr Thr Lys Gly Pro Ala Leu 
305                 310                 315                 320 
Thr Thr Pro Lys Glu Pro Thr Pro Thr Thr Pro Lys Glu Pro Ala Ser 
                325                 330                 335     
Thr Thr Pro Lys Glu Pro Thr Pro Thr Thr Ile Lys Ser Ala Pro Thr 
            340                 345                 350         
Thr Pro Lys Glu Pro Ala Pro Thr Thr Thr Lys Ser Ala Pro Thr Thr 
        355                 360                 365             
Pro Lys Glu Pro Ala Pro Thr Thr Thr Lys Glu Pro Ala Pro Thr Thr 
    370                 375                 380                 
Pro Lys Glu Pro Ala Pro Thr Thr Thr Lys Glu Pro Ala Pro Thr Thr 
385                 390                 395                 400 
Thr Lys Ser Ala Pro Thr Thr Pro Lys Glu Pro Ala Pro Thr Thr Pro 
                405                 410                 415     
Lys Lys Pro Ala Pro Thr Thr Pro Lys Glu Pro Ala Pro Thr Thr Pro 
            420                 425                 430         
Lys Glu Pro Thr Pro Thr Thr Pro Lys Glu Pro Ala Pro Thr Thr Lys 
        435                 440                 445             
Glu Pro Ala Pro Thr Thr Pro Lys Glu Pro Ala Pro Thr Ala Pro Lys 
    450                 455                 460                 
Lys Pro Ala Pro Thr Thr Pro Lys Glu Pro Ala Pro Thr Thr Pro Lys 
465                 470                 475                 480 
Glu Pro Ala Pro Thr Thr Thr Lys Glu Pro Ser Pro Thr Thr Pro Lys 
                485                 490                 495     
Glu Pro Ala Pro Thr Thr Thr Lys Ser Ala Pro Thr Thr Thr Lys Glu 
            500                 505                 510         
Pro Ala Pro Thr Thr Thr Lys Ser Ala Pro Thr Thr Pro Lys Glu Pro 
        515                 520                 525             
Ser Pro Thr Thr Thr Lys Glu Pro Ala Pro Thr Thr Pro Lys Glu Pro 
    530                 535                 540                 
Ala Pro Thr Thr Pro Lys Lys Pro Ala Pro Thr Thr Pro Lys Glu Pro 
545                 550                 555                 560 
Ala Pro Thr Thr Pro Lys Glu Pro Ala Pro Thr Thr Thr Lys Lys Pro 
                565                 570                 575     
Ala Pro Thr Thr Pro Lys Glu Pro Ala Pro Thr Thr Pro Lys Glu Thr 
            580                 585                 590         
Ala Pro Thr Thr Pro Lys Lys Leu Thr Pro Thr Thr Pro Glu Lys Leu 
        595                 600                 605             
Ala Pro Thr Thr Pro Glu Lys Pro Ala Pro Thr Thr Pro Glu Glu Leu 
    610                 615                 620                 
Ala Pro Thr Thr Pro Glu Glu Pro Thr Pro Thr Thr Pro Glu Glu Pro 
625                 630                 635                 640 
Ala Pro Thr Thr Pro Lys Ala Ala Ala Pro Asn Thr Pro Lys Glu Pro 
                645                 650                 655     
Ala Pro Thr Thr Pro Lys Glu Pro Ala Pro Thr Thr Pro Lys Glu Pro 
            660                 665                 670         
Ala Pro Thr Thr Pro Lys Glu Thr Ala Pro Thr Thr Pro Lys Gly Thr 
        675                 680                 685             
Ala Pro Thr Thr Leu Lys Glu Pro Ala Pro Thr Thr Pro Lys Lys Pro 
    690                 695                 700                 
Ala Pro Lys Glu Leu Ala Pro Thr Thr Thr Lys Glu Pro Thr Ser Thr 
705                 710                 715                 720 
Thr Cys Asp Lys Pro Ala Pro Thr Thr Pro Lys Gly Thr Ala Pro Thr 
                725                 730                 735     
Thr Pro Lys Glu Pro Ala Pro Thr Thr Pro Lys Glu Pro Ala Pro Thr 
            740                 745                 750         
Thr Pro Lys Gly Thr Ala Pro Thr Thr Leu Lys Glu Pro Ala Pro Thr 
        755                 760                 765             
Thr Pro Lys Lys Pro Ala Pro Lys Glu Leu Ala Pro Thr Thr Thr Lys 
    770                 775                 780                 
Gly Pro Thr Ser Thr Thr Ser Asp Lys Pro Ala Pro Thr Thr Pro Lys 
785                 790                 795                 800 
Glu Thr Ala Pro Thr Thr Pro Lys Glu Pro Ala Pro Thr Thr Pro Lys 
                805                 810                 815     
Lys Pro Ala Pro Thr Thr Pro Glu Thr Pro Pro Pro Thr Thr Ser Glu 
            820                 825                 830         
Val Ser Thr Pro Thr Thr Thr Lys Glu Pro Thr Thr Ile His Lys Ser 
        835                 840                 845             
Pro Asp Glu Ser Thr Pro Glu Leu Ser Ala Glu Pro Thr Pro Lys Ala 
    850                 855                 860                 
Leu Glu Asn Ser Pro Lys Glu Pro Gly Val Pro Thr Thr Lys Thr Pro 
865                 870                 875                 880 
Ala Ala Thr Lys Pro Glu Met Thr Thr Thr Ala Lys Asp Lys Thr Thr 
                885                 890                 895     
Glu Arg Asp Leu Arg Thr Thr Pro Glu Thr Thr Thr Ala Ala Pro Lys 
            900                 905                 910         
Met Thr Lys Glu Thr Ala Thr Thr Thr Glu Lys Thr Thr Glu Ser Lys 
        915                 920                 925             
Ile Thr Ala Thr Thr Thr Gln Val Thr Ser Thr Thr Thr Gln Asp Thr 
    930                 935                 940                 
Thr Pro Phe Lys Ile Thr Thr Leu Lys Thr Thr Thr Leu Ala Pro Lys 
945                 950                 955                 960 
Val Thr Thr Thr Lys Lys Thr Ile Thr Thr Thr Glu Ile Met Asn Lys 
                965                 970                 975     
Pro Glu Glu Thr Ala Lys Pro Lys Asp Arg Ala Thr Asn Ser Lys Ala 
            980                 985                 990         
Thr Thr Pro Lys Pro Gln Lys Pro Thr Lys Ala Pro Lys Lys Pro Thr 
        995                 1000                1005            
Ser Thr Lys Lys Pro Lys Thr Met Pro Arg Val Arg Lys Pro Lys Thr 
    1010                1015                1020                
Thr Pro Thr Pro Arg Lys Met Thr Ser Thr Met Pro Glu Leu Asn Pro 
1025                1030                1035                1040
Thr Ser Arg Ile Ala Glu Ala Met Leu Gln Thr Thr Thr Arg Pro Asn 
                1045                1050                1055    
Gln Thr Pro Asn Ser Lys Leu Val Glu Val Asn Pro Lys Ser Glu Asp 
            1060                1065                1070        
Ala Gly Gly Ala Glu Gly Glu Thr Pro His Met Leu Leu Arg Pro His 
        1075                1080                1085            
Val Phe Met Pro Glu Val Thr Pro Asp Met Asp Tyr Leu Pro Arg Val 
    1090                1095                1100                
Pro Asn Gln Gly Ile Ile Ile Asn Pro Met Leu Ser Asp Glu Thr Asn 
1105                1110                1115                1120
Ile Cys Asn Gly Lys Pro Val Asp Gly Leu Thr Thr Leu Arg Asn Gly 
                1125                1130                1135    
Thr Leu Val Ala Phe Arg Gly His Tyr Phe Trp Met Leu Ser Pro Phe 
            1140                1145                1150        
Ser Pro Pro Ser Pro Ala Arg Arg Ile Thr Glu Val Trp Gly Ile Pro 
        1155                1160                1165            
Ser Pro Ile Asp Thr Val Phe Thr Arg Cys Asn Cys Glu Gly Lys Thr 
    1170                1175                1180                
Phe Phe Phe Lys Asp Ser Gln Tyr Trp Arg Phe Thr Asn Asp Ile Lys 
1185                1190                1195                1200
Asp Ala Gly Tyr Pro Lys Pro Ile Phe Lys Gly Phe Gly Gly Leu Thr 
                1205                1210                1215    
Gly Gln Ile Val Ala Ala Leu Ser Thr Ala Lys Tyr Lys Asn Trp Pro 
            1220                1225                1230        
Glu Ser Val Tyr Phe Phe Lys Arg Gly Gly Ser Ile Gln Gln Tyr Ile 
        1235                1240                1245            
Tyr Lys Gln Glu Pro Val Gln Lys Cys Pro Gly Arg Arg Pro Ala Leu 
    1250                1255                1260                
Asn Tyr Pro Val Tyr Gly Glu Thr Thr Gln Val Arg Arg Arg Arg Phe 
1265                1270                1275                1280
Glu Arg Ala Ile Gly Pro Ser Gln Thr His Thr Ile Arg Ile Gln Tyr 
                1285                1290                1295    
Ser Pro Ala Arg Leu Ala Tyr Gln Asp Lys Gly Val Leu His Asn Glu 
            1300                1305                1310        
Val Lys Val Ser Ile Leu Trp Arg Gly Leu Pro Asn Val Val Thr Ser 
        1315                1320                1325            
Ala Ile Ser Leu Pro Asn Ile Arg Lys Pro Asp Gly Tyr Asp Tyr Tyr 
    1330                1335                1340                
Ala Phe Ser Lys Asp Gln Tyr Tyr Asn Ile Asp Val Pro Ser Arg Thr 
1345                1350                1355                1360
Ala Arg Ala Ile Thr Thr Arg Ser Gly Gln Thr Leu Ser Lys Val Trp 
                1365                1370                1375    
Tyr Asn Cys Pro 
            1380

<210> 43
<211> 1363
<212> PRT
<213> Homo sapiens


<220> 
<223> PRG4 isoform B

<400> 43
Met Ala Trp Lys Thr Leu Pro Ile Tyr Leu Leu Leu Leu Leu Ser Val 
1               5                   10                  15      
Phe Val Ile Gln Gln Val Ser Ser Gln Glu Leu Ser Cys Lys Gly Arg 
            20                  25                  30          
Cys Phe Glu Ser Phe Glu Arg Gly Arg Glu Cys Asp Cys Asp Ala Gln 
        35                  40                  45              
Cys Lys Lys Tyr Asp Lys Cys Cys Pro Asp Tyr Glu Ser Phe Cys Ala 
    50                  55                  60                  
Glu Val His Asn Pro Thr Ser Pro Pro Ser Ser Lys Lys Ala Pro Pro 
65                  70                  75                  80  
Pro Ser Gly Ala Ser Gln Thr Ile Lys Ser Thr Thr Lys Arg Ser Pro 
                85                  90                  95      
Lys Pro Pro Asn Lys Lys Lys Thr Lys Lys Val Ile Glu Ser Glu Glu 
            100                 105                 110         
Ile Thr Glu Glu His Ser Val Ser Glu Asn Gln Glu Ser Ser Ser Ser 
        115                 120                 125             
Ser Ser Ser Ser Ser Ser Ser Ser Thr Ile Arg Lys Ile Lys Ser Ser 
    130                 135                 140                 
Lys Asn Ser Ala Ala Asn Arg Glu Leu Gln Lys Lys Leu Lys Val Lys 
145                 150                 155                 160 
Asp Asn Lys Lys Asn Arg Thr Lys Lys Lys Pro Thr Pro Lys Pro Pro 
                165                 170                 175     
Val Val Asp Glu Ala Gly Ser Gly Leu Asp Asn Gly Asp Phe Lys Val 
            180                 185                 190         
Thr Thr Pro Asp Thr Ser Thr Thr Gln His Asn Lys Val Ser Thr Ser 
        195                 200                 205             
Pro Lys Ile Thr Thr Ala Lys Pro Ile Asn Pro Arg Pro Ser Leu Pro 
    210                 215                 220                 
Pro Asn Ser Asp Thr Ser Lys Glu Thr Ser Leu Thr Val Asn Lys Glu 
225                 230                 235                 240 
Thr Thr Val Glu Thr Lys Glu Thr Thr Thr Thr Asn Lys Gln Thr Ser 
                245                 250                 255     
Thr Asp Gly Lys Glu Lys Thr Thr Ser Ala Lys Glu Thr Gln Ser Ile 
            260                 265                 270         
Glu Lys Thr Ser Ala Lys Asp Leu Ala Pro Thr Ser Lys Val Leu Ala 
        275                 280                 285             
Lys Pro Thr Pro Lys Ala Glu Thr Thr Thr Lys Gly Pro Ala Leu Thr 
    290                 295                 300                 
Thr Pro Lys Glu Pro Thr Pro Thr Thr Pro Lys Glu Pro Ala Ser Thr 
305                 310                 315                 320 
Thr Pro Lys Glu Pro Thr Pro Thr Thr Ile Lys Ser Ala Pro Thr Thr 
                325                 330                 335     
Pro Lys Glu Pro Ala Pro Thr Thr Thr Lys Ser Ala Pro Thr Thr Pro 
            340                 345                 350         
Lys Glu Pro Ala Pro Thr Thr Thr Lys Glu Pro Ala Pro Thr Thr Pro 
        355                 360                 365             
Lys Glu Pro Ala Pro Thr Thr Thr Lys Glu Pro Ala Pro Thr Thr Thr 
    370                 375                 380                 
Lys Ser Ala Pro Thr Thr Pro Lys Glu Pro Ala Pro Thr Thr Pro Lys 
385                 390                 395                 400 
Lys Pro Ala Pro Thr Thr Pro Lys Glu Pro Ala Pro Thr Thr Pro Lys 
                405                 410                 415     
Glu Pro Thr Pro Thr Thr Pro Lys Glu Pro Ala Pro Thr Thr Lys Glu 
            420                 425                 430         
Pro Ala Pro Thr Thr Pro Lys Glu Pro Ala Pro Thr Ala Pro Lys Lys 
        435                 440                 445             
Pro Ala Pro Thr Thr Pro Lys Glu Pro Ala Pro Thr Thr Pro Lys Glu 
    450                 455                 460                 
Pro Ala Pro Thr Thr Thr Lys Glu Pro Ser Pro Thr Thr Pro Lys Glu 
465                 470                 475                 480 
Pro Ala Pro Thr Thr Thr Lys Ser Ala Pro Thr Thr Thr Lys Glu Pro 
                485                 490                 495     
Ala Pro Thr Thr Thr Lys Ser Ala Pro Thr Thr Pro Lys Glu Pro Ser 
            500                 505                 510         
Pro Thr Thr Thr Lys Glu Pro Ala Pro Thr Thr Pro Lys Glu Pro Ala 
        515                 520                 525             
Pro Thr Thr Pro Lys Lys Pro Ala Pro Thr Thr Pro Lys Glu Pro Ala 
    530                 535                 540                 
Pro Thr Thr Pro Lys Glu Pro Ala Pro Thr Thr Thr Lys Lys Pro Ala 
545                 550                 555                 560 
Pro Thr Thr Pro Lys Glu Pro Ala Pro Thr Thr Pro Lys Glu Thr Ala 
                565                 570                 575     
Pro Thr Thr Pro Lys Lys Leu Thr Pro Thr Thr Pro Glu Lys Leu Ala 
            580                 585                 590         
Pro Thr Thr Pro Glu Lys Pro Ala Pro Thr Thr Pro Glu Glu Leu Ala 
        595                 600                 605             
Pro Thr Thr Pro Glu Glu Pro Thr Pro Thr Thr Pro Glu Glu Pro Ala 
    610                 615                 620                 
Pro Thr Thr Pro Lys Ala Ala Ala Pro Asn Thr Pro Lys Glu Pro Ala 
625                 630                 635                 640 
Pro Thr Thr Pro Lys Glu Pro Ala Pro Thr Thr Pro Lys Glu Pro Ala 
                645                 650                 655     
Pro Thr Thr Pro Lys Glu Thr Ala Pro Thr Thr Pro Lys Gly Thr Ala 
            660                 665                 670         
Pro Thr Thr Leu Lys Glu Pro Ala Pro Thr Thr Pro Lys Lys Pro Ala 
        675                 680                 685             
Pro Lys Glu Leu Ala Pro Thr Thr Thr Lys Glu Pro Thr Ser Thr Thr 
    690                 695                 700                 
Cys Asp Lys Pro Ala Pro Thr Thr Pro Lys Gly Thr Ala Pro Thr Thr 
705                 710                 715                 720 
Pro Lys Glu Pro Ala Pro Thr Thr Pro Lys Glu Pro Ala Pro Thr Thr 
                725                 730                 735     
Pro Lys Gly Thr Ala Pro Thr Thr Leu Lys Glu Pro Ala Pro Thr Thr 
            740                 745                 750         
Pro Lys Lys Pro Ala Pro Lys Glu Leu Ala Pro Thr Thr Thr Lys Gly 
        755                 760                 765             
Pro Thr Ser Thr Thr Ser Asp Lys Pro Ala Pro Thr Thr Pro Lys Glu 
    770                 775                 780                 
Thr Ala Pro Thr Thr Pro Lys Glu Pro Ala Pro Thr Thr Pro Lys Lys 
785                 790                 795                 800 
Pro Ala Pro Thr Thr Pro Glu Thr Pro Pro Pro Thr Thr Ser Glu Val 
                805                 810                 815     
Ser Thr Pro Thr Thr Thr Lys Glu Pro Thr Thr Ile His Lys Ser Pro 
            820                 825                 830         
Asp Glu Ser Thr Pro Glu Leu Ser Ala Glu Pro Thr Pro Lys Ala Leu 
        835                 840                 845             
Glu Asn Ser Pro Lys Glu Pro Gly Val Pro Thr Thr Lys Thr Pro Ala 
    850                 855                 860                 
Ala Thr Lys Pro Glu Met Thr Thr Thr Ala Lys Asp Lys Thr Thr Glu 
865                 870                 875                 880 
Arg Asp Leu Arg Thr Thr Pro Glu Thr Thr Thr Ala Ala Pro Lys Met 
                885                 890                 895     
Thr Lys Glu Thr Ala Thr Thr Thr Glu Lys Thr Thr Glu Ser Lys Ile 
            900                 905                 910         
Thr Ala Thr Thr Thr Gln Val Thr Ser Thr Thr Thr Gln Asp Thr Thr 
        915                 920                 925             
Pro Phe Lys Ile Thr Thr Leu Lys Thr Thr Thr Leu Ala Pro Lys Val 
    930                 935                 940                 
Thr Thr Thr Lys Lys Thr Ile Thr Thr Thr Glu Ile Met Asn Lys Pro 
945                 950                 955                 960 
Glu Glu Thr Ala Lys Pro Lys Asp Arg Ala Thr Asn Ser Lys Ala Thr 
                965                 970                 975     
Thr Pro Lys Pro Gln Lys Pro Thr Lys Ala Pro Lys Lys Pro Thr Ser 
            980                 985                 990         
Thr Lys Lys Pro Lys Thr Met Pro Arg Val Arg Lys Pro Lys Thr Thr 
        995                 1000                1005            
Pro Thr Pro Arg Lys Met Thr Ser Thr Met Pro Glu Leu Asn Pro Thr 
    1010                1015                1020                
Ser Arg Ile Ala Glu Ala Met Leu Gln Thr Thr Thr Arg Pro Asn Gln 
1025                1030                1035                1040
Thr Pro Asn Ser Lys Leu Val Glu Val Asn Pro Lys Ser Glu Asp Ala 
                1045                1050                1055    
Gly Gly Ala Glu Gly Glu Thr Pro His Met Leu Leu Arg Pro His Val 
            1060                1065                1070        
Phe Met Pro Glu Val Thr Pro Asp Met Asp Tyr Leu Pro Arg Val Pro 
        1075                1080                1085            
Asn Gln Gly Ile Ile Ile Asn Pro Met Leu Ser Asp Glu Thr Asn Ile 
    1090                1095                1100                
Cys Asn Gly Lys Pro Val Asp Gly Leu Thr Thr Leu Arg Asn Gly Thr 
1105                1110                1115                1120
Leu Val Ala Phe Arg Gly His Tyr Phe Trp Met Leu Ser Pro Phe Ser 
                1125                1130                1135    
Pro Pro Ser Pro Ala Arg Arg Ile Thr Glu Val Trp Gly Ile Pro Ser 
            1140                1145                1150        
Pro Ile Asp Thr Val Phe Thr Arg Cys Asn Cys Glu Gly Lys Thr Phe 
        1155                1160                1165            
Phe Phe Lys Asp Ser Gln Tyr Trp Arg Phe Thr Asn Asp Ile Lys Asp 
    1170                1175                1180                
Ala Gly Tyr Pro Lys Pro Ile Phe Lys Gly Phe Gly Gly Leu Thr Gly 
1185                1190                1195                1200
Gln Ile Val Ala Ala Leu Ser Thr Ala Lys Tyr Lys Asn Trp Pro Glu 
                1205                1210                1215    
Ser Val Tyr Phe Phe Lys Arg Gly Gly Ser Ile Gln Gln Tyr Ile Tyr 
            1220                1225                1230        
Lys Gln Glu Pro Val Gln Lys Cys Pro Gly Arg Arg Pro Ala Leu Asn 
        1235                1240                1245            
Tyr Pro Val Tyr Gly Glu Thr Thr Gln Val Arg Arg Arg Arg Phe Glu 
    1250                1255                1260                
Arg Ala Ile Gly Pro Ser Gln Thr His Thr Ile Arg Ile Gln Tyr Ser 
1265                1270                1275                1280
Pro Ala Arg Leu Ala Tyr Gln Asp Lys Gly Val Leu His Asn Glu Val 
                1285                1290                1295    
Lys Val Ser Ile Leu Trp Arg Gly Leu Pro Asn Val Val Thr Ser Ala 
            1300                1305                1310        
Ile Ser Leu Pro Asn Ile Arg Lys Pro Asp Gly Tyr Asp Tyr Tyr Ala 
        1315                1320                1325            
Phe Ser Lys Asp Gln Tyr Tyr Asn Ile Asp Val Pro Ser Arg Thr Ala 
    1330                1335                1340                
Arg Ala Ile Thr Thr Arg Ser Gly Gln Thr Leu Ser Lys Val Trp Tyr 
1345                1350                1355                1360
Asn Cys Pro 
            

<210> 44
<211> 1311
<212> PRT
<213> Homo sapiens


<220> 
<223> PRG4 isoform C

<400> 44
Met Ala Trp Lys Thr Leu Pro Ile Tyr Leu Leu Leu Leu Leu Ser Val 
1               5                   10                  15      
Phe Val Ile Gln Gln Val Ser Ser Gln Asp Leu Ser Ser Cys Ala Gly 
            20                  25                  30          
Arg Cys Gly Glu Gly Tyr Ser Arg Asp Ala Thr Cys Asn Cys Asp Tyr 
        35                  40                  45              
Asn Cys Gln His Tyr Met Glu Cys Cys Pro Asp Phe Lys Arg Val Cys 
    50                  55                  60                  
Thr Ala Glu Leu Ser Cys Lys Gly Arg Cys Phe Glu Ser Phe Glu Arg 
65                  70                  75                  80  
Gly Arg Glu Cys Asp Cys Asp Ala Gln Cys Lys Lys Tyr Asp Lys Cys 
                85                  90                  95      
Cys Pro Asp Tyr Glu Ser Phe Cys Ala Glu Val Lys Asp Asn Lys Lys 
            100                 105                 110         
Asn Arg Thr Lys Lys Lys Pro Thr Pro Lys Pro Pro Val Val Asp Glu 
        115                 120                 125             
Ala Gly Ser Gly Leu Asp Asn Gly Asp Phe Lys Val Thr Thr Pro Asp 
    130                 135                 140                 
Thr Ser Thr Thr Gln His Asn Lys Val Ser Thr Ser Pro Lys Ile Thr 
145                 150                 155                 160 
Thr Ala Lys Pro Ile Asn Pro Arg Pro Ser Leu Pro Pro Asn Ser Asp 
                165                 170                 175     
Thr Ser Lys Glu Thr Ser Leu Thr Val Asn Lys Glu Thr Thr Val Glu 
            180                 185                 190         
Thr Lys Glu Thr Thr Thr Thr Asn Lys Gln Thr Ser Thr Asp Gly Lys 
        195                 200                 205             
Glu Lys Thr Thr Ser Ala Lys Glu Thr Gln Ser Ile Glu Lys Thr Ser 
    210                 215                 220                 
Ala Lys Asp Leu Ala Pro Thr Ser Lys Val Leu Ala Lys Pro Thr Pro 
225                 230                 235                 240 
Lys Ala Glu Thr Thr Thr Lys Gly Pro Ala Leu Thr Thr Pro Lys Glu 
                245                 250                 255     
Pro Thr Pro Thr Thr Pro Lys Glu Pro Ala Ser Thr Thr Pro Lys Glu 
            260                 265                 270         
Pro Thr Pro Thr Thr Ile Lys Ser Ala Pro Thr Thr Pro Lys Glu Pro 
        275                 280                 285             
Ala Pro Thr Thr Thr Lys Ser Ala Pro Thr Thr Pro Lys Glu Pro Ala 
    290                 295                 300                 
Pro Thr Thr Thr Lys Glu Pro Ala Pro Thr Thr Pro Lys Glu Pro Ala 
305                 310                 315                 320 
Pro Thr Thr Thr Lys Glu Pro Ala Pro Thr Thr Thr Lys Ser Ala Pro 
                325                 330                 335     
Thr Thr Pro Lys Glu Pro Ala Pro Thr Thr Pro Lys Lys Pro Ala Pro 
            340                 345                 350         
Thr Thr Pro Lys Glu Pro Ala Pro Thr Thr Pro Lys Glu Pro Thr Pro 
        355                 360                 365             
Thr Thr Pro Lys Glu Pro Ala Pro Thr Thr Lys Glu Pro Ala Pro Thr 
    370                 375                 380                 
Thr Pro Lys Glu Pro Ala Pro Thr Ala Pro Lys Lys Pro Ala Pro Thr 
385                 390                 395                 400 
Thr Pro Lys Glu Pro Ala Pro Thr Thr Pro Lys Glu Pro Ala Pro Thr 
                405                 410                 415     
Thr Thr Lys Glu Pro Ser Pro Thr Thr Pro Lys Glu Pro Ala Pro Thr 
            420                 425                 430         
Thr Thr Lys Ser Ala Pro Thr Thr Thr Lys Glu Pro Ala Pro Thr Thr 
        435                 440                 445             
Thr Lys Ser Ala Pro Thr Thr Pro Lys Glu Pro Ser Pro Thr Thr Thr 
    450                 455                 460                 
Lys Glu Pro Ala Pro Thr Thr Pro Lys Glu Pro Ala Pro Thr Thr Pro 
465                 470                 475                 480 
Lys Lys Pro Ala Pro Thr Thr Pro Lys Glu Pro Ala Pro Thr Thr Pro 
                485                 490                 495     
Lys Glu Pro Ala Pro Thr Thr Thr Lys Lys Pro Ala Pro Thr Thr Pro 
            500                 505                 510         
Lys Glu Pro Ala Pro Thr Thr Pro Lys Glu Thr Ala Pro Thr Thr Pro 
        515                 520                 525             
Lys Lys Leu Thr Pro Thr Thr Pro Glu Lys Leu Ala Pro Thr Thr Pro 
    530                 535                 540                 
Glu Lys Pro Ala Pro Thr Thr Pro Glu Glu Leu Ala Pro Thr Thr Pro 
545                 550                 555                 560 
Glu Glu Pro Thr Pro Thr Thr Pro Glu Glu Pro Ala Pro Thr Thr Pro 
                565                 570                 575     
Lys Ala Ala Ala Pro Asn Thr Pro Lys Glu Pro Ala Pro Thr Thr Pro 
            580                 585                 590         
Lys Glu Pro Ala Pro Thr Thr Pro Lys Glu Pro Ala Pro Thr Thr Pro 
        595                 600                 605             
Lys Glu Thr Ala Pro Thr Thr Pro Lys Gly Thr Ala Pro Thr Thr Leu 
    610                 615                 620                 
Lys Glu Pro Ala Pro Thr Thr Pro Lys Lys Pro Ala Pro Lys Glu Leu 
625                 630                 635                 640 
Ala Pro Thr Thr Thr Lys Glu Pro Thr Ser Thr Thr Cys Asp Lys Pro 
                645                 650                 655     
Ala Pro Thr Thr Pro Lys Gly Thr Ala Pro Thr Thr Pro Lys Glu Pro 
            660                 665                 670         
Ala Pro Thr Thr Pro Lys Glu Pro Ala Pro Thr Thr Pro Lys Gly Thr 
        675                 680                 685             
Ala Pro Thr Thr Leu Lys Glu Pro Ala Pro Thr Thr Pro Lys Lys Pro 
    690                 695                 700                 
Ala Pro Lys Glu Leu Ala Pro Thr Thr Thr Lys Gly Pro Thr Ser Thr 
705                 710                 715                 720 
Thr Ser Asp Lys Pro Ala Pro Thr Thr Pro Lys Glu Thr Ala Pro Thr 
                725                 730                 735     
Thr Pro Lys Glu Pro Ala Pro Thr Thr Pro Lys Lys Pro Ala Pro Thr 
            740                 745                 750         
Thr Pro Glu Thr Pro Pro Pro Thr Thr Ser Glu Val Ser Thr Pro Thr 
        755                 760                 765             
Thr Thr Lys Glu Pro Thr Thr Ile His Lys Ser Pro Asp Glu Ser Thr 
    770                 775                 780                 
Pro Glu Leu Ser Ala Glu Pro Thr Pro Lys Ala Leu Glu Asn Ser Pro 
785                 790                 795                 800 
Lys Glu Pro Gly Val Pro Thr Thr Lys Thr Pro Ala Ala Thr Lys Pro 
                805                 810                 815     
Glu Met Thr Thr Thr Ala Lys Asp Lys Thr Thr Glu Arg Asp Leu Arg 
            820                 825                 830         
Thr Thr Pro Glu Thr Thr Thr Ala Ala Pro Lys Met Thr Lys Glu Thr 
        835                 840                 845             
Ala Thr Thr Thr Glu Lys Thr Thr Glu Ser Lys Ile Thr Ala Thr Thr 
    850                 855                 860                 
Thr Gln Val Thr Ser Thr Thr Thr Gln Asp Thr Thr Pro Phe Lys Ile 
865                 870                 875                 880 
Thr Thr Leu Lys Thr Thr Thr Leu Ala Pro Lys Val Thr Thr Thr Lys 
                885                 890                 895     
Lys Thr Ile Thr Thr Thr Glu Ile Met Asn Lys Pro Glu Glu Thr Ala 
            900                 905                 910         
Lys Pro Lys Asp Arg Ala Thr Asn Ser Lys Ala Thr Thr Pro Lys Pro 
        915                 920                 925             
Gln Lys Pro Thr Lys Ala Pro Lys Lys Pro Thr Ser Thr Lys Lys Pro 
    930                 935                 940                 
Lys Thr Met Pro Arg Val Arg Lys Pro Lys Thr Thr Pro Thr Pro Arg 
945                 950                 955                 960 
Lys Met Thr Ser Thr Met Pro Glu Leu Asn Pro Thr Ser Arg Ile Ala 
                965                 970                 975     
Glu Ala Met Leu Gln Thr Thr Thr Arg Pro Asn Gln Thr Pro Asn Ser 
            980                 985                 990         
Lys Leu Val Glu Val Asn Pro Lys Ser Glu Asp Ala Gly Gly Ala Glu 
        995                 1000                1005            
Gly Glu Thr Pro His Met Leu Leu Arg Pro His Val Phe Met Pro Glu 
    1010                1015                1020                
Val Thr Pro Asp Met Asp Tyr Leu Pro Arg Val Pro Asn Gln Gly Ile 
1025                1030                1035                1040
Ile Ile Asn Pro Met Leu Ser Asp Glu Thr Asn Ile Cys Asn Gly Lys 
                1045                1050                1055    
Pro Val Asp Gly Leu Thr Thr Leu Arg Asn Gly Thr Leu Val Ala Phe 
            1060                1065                1070        
Arg Gly His Tyr Phe Trp Met Leu Ser Pro Phe Ser Pro Pro Ser Pro 
        1075                1080                1085            
Ala Arg Arg Ile Thr Glu Val Trp Gly Ile Pro Ser Pro Ile Asp Thr 
    1090                1095                1100                
Val Phe Thr Arg Cys Asn Cys Glu Gly Lys Thr Phe Phe Phe Lys Asp 
1105                1110                1115                1120
Ser Gln Tyr Trp Arg Phe Thr Asn Asp Ile Lys Asp Ala Gly Tyr Pro 
                1125                1130                1135    
Lys Pro Ile Phe Lys Gly Phe Gly Gly Leu Thr Gly Gln Ile Val Ala 
            1140                1145                1150        
Ala Leu Ser Thr Ala Lys Tyr Lys Asn Trp Pro Glu Ser Val Tyr Phe 
        1155                1160                1165            
Phe Lys Arg Gly Gly Ser Ile Gln Gln Tyr Ile Tyr Lys Gln Glu Pro 
    1170                1175                1180                
Val Gln Lys Cys Pro Gly Arg Arg Pro Ala Leu Asn Tyr Pro Val Tyr 
1185                1190                1195                1200
Gly Glu Thr Thr Gln Val Arg Arg Arg Arg Phe Glu Arg Ala Ile Gly 
                1205                1210                1215    
Pro Ser Gln Thr His Thr Ile Arg Ile Gln Tyr Ser Pro Ala Arg Leu 
            1220                1225                1230        
Ala Tyr Gln Asp Lys Gly Val Leu His Asn Glu Val Lys Val Ser Ile 
        1235                1240                1245            
Leu Trp Arg Gly Leu Pro Asn Val Val Thr Ser Ala Ile Ser Leu Pro 
    1250                1255                1260                
Asn Ile Arg Lys Pro Asp Gly Tyr Asp Tyr Tyr Ala Phe Ser Lys Asp 
1265                1270                1275                1280
Gln Tyr Tyr Asn Ile Asp Val Pro Ser Arg Thr Ala Arg Ala Ile Thr 
                1285                1290                1295    
Thr Arg Ser Gly Gln Thr Leu Ser Lys Val Trp Tyr Asn Cys Pro 
            1300                1305                1310    

<210> 45
<211> 1270
<212> PRT
<213> Homo sapiens


<220> 
<223> PRG4 isoform D

<400> 45
Met Ala Trp Lys Thr Leu Pro Ile Tyr Leu Leu Leu Leu Leu Ser Val 
1               5                   10                  15      
Phe Val Ile Gln Gln Val Ser Ser Gln Glu Leu Ser Cys Lys Gly Arg 
            20                  25                  30          
Cys Phe Glu Ser Phe Glu Arg Gly Arg Glu Cys Asp Cys Asp Ala Gln 
        35                  40                  45              
Cys Lys Lys Tyr Asp Lys Cys Cys Pro Asp Tyr Glu Ser Phe Cys Ala 
    50                  55                  60                  
Glu Val Lys Asp Asn Lys Lys Asn Arg Thr Lys Lys Lys Pro Thr Pro 
65                  70                  75                  80  
Lys Pro Pro Val Val Asp Glu Ala Gly Ser Gly Leu Asp Asn Gly Asp 
                85                  90                  95      
Phe Lys Val Thr Thr Pro Asp Thr Ser Thr Thr Gln His Asn Lys Val 
            100                 105                 110         
Ser Thr Ser Pro Lys Ile Thr Thr Ala Lys Pro Ile Asn Pro Arg Pro 
        115                 120                 125             
Ser Leu Pro Pro Asn Ser Asp Thr Ser Lys Glu Thr Ser Leu Thr Val 
    130                 135                 140                 
Asn Lys Glu Thr Thr Val Glu Thr Lys Glu Thr Thr Thr Thr Asn Lys 
145                 150                 155                 160 
Gln Thr Ser Thr Asp Gly Lys Glu Lys Thr Thr Ser Ala Lys Glu Thr 
                165                 170                 175     
Gln Ser Ile Glu Lys Thr Ser Ala Lys Asp Leu Ala Pro Thr Ser Lys 
            180                 185                 190         
Val Leu Ala Lys Pro Thr Pro Lys Ala Glu Thr Thr Thr Lys Gly Pro 
        195                 200                 205             
Ala Leu Thr Thr Pro Lys Glu Pro Thr Pro Thr Thr Pro Lys Glu Pro 
    210                 215                 220                 
Ala Ser Thr Thr Pro Lys Glu Pro Thr Pro Thr Thr Ile Lys Ser Ala 
225                 230                 235                 240 
Pro Thr Thr Pro Lys Glu Pro Ala Pro Thr Thr Thr Lys Ser Ala Pro 
                245                 250                 255     
Thr Thr Pro Lys Glu Pro Ala Pro Thr Thr Thr Lys Glu Pro Ala Pro 
            260                 265                 270         
Thr Thr Pro Lys Glu Pro Ala Pro Thr Thr Thr Lys Glu Pro Ala Pro 
        275                 280                 285             
Thr Thr Thr Lys Ser Ala Pro Thr Thr Pro Lys Glu Pro Ala Pro Thr 
    290                 295                 300                 
Thr Pro Lys Lys Pro Ala Pro Thr Thr Pro Lys Glu Pro Ala Pro Thr 
305                 310                 315                 320 
Thr Pro Lys Glu Pro Thr Pro Thr Thr Pro Lys Glu Pro Ala Pro Thr 
                325                 330                 335     
Thr Lys Glu Pro Ala Pro Thr Thr Pro Lys Glu Pro Ala Pro Thr Ala 
            340                 345                 350         
Pro Lys Lys Pro Ala Pro Thr Thr Pro Lys Glu Pro Ala Pro Thr Thr 
        355                 360                 365             
Pro Lys Glu Pro Ala Pro Thr Thr Thr Lys Glu Pro Ser Pro Thr Thr 
    370                 375                 380                 
Pro Lys Glu Pro Ala Pro Thr Thr Thr Lys Ser Ala Pro Thr Thr Thr 
385                 390                 395                 400 
Lys Glu Pro Ala Pro Thr Thr Thr Lys Ser Ala Pro Thr Thr Pro Lys 
                405                 410                 415     
Glu Pro Ser Pro Thr Thr Thr Lys Glu Pro Ala Pro Thr Thr Pro Lys 
            420                 425                 430         
Glu Pro Ala Pro Thr Thr Pro Lys Lys Pro Ala Pro Thr Thr Pro Lys 
        435                 440                 445             
Glu Pro Ala Pro Thr Thr Pro Lys Glu Pro Ala Pro Thr Thr Thr Lys 
    450                 455                 460                 
Lys Pro Ala Pro Thr Thr Pro Lys Glu Pro Ala Pro Thr Thr Pro Lys 
465                 470                 475                 480 
Glu Thr Ala Pro Thr Thr Pro Lys Lys Leu Thr Pro Thr Thr Pro Glu 
                485                 490                 495     
Lys Leu Ala Pro Thr Thr Pro Glu Lys Pro Ala Pro Thr Thr Pro Glu 
            500                 505                 510         
Glu Leu Ala Pro Thr Thr Pro Glu Glu Pro Thr Pro Thr Thr Pro Glu 
        515                 520                 525             
Glu Pro Ala Pro Thr Thr Pro Lys Ala Ala Ala Pro Asn Thr Pro Lys 
    530                 535                 540                 
Glu Pro Ala Pro Thr Thr Pro Lys Glu Pro Ala Pro Thr Thr Pro Lys 
545                 550                 555                 560 
Glu Pro Ala Pro Thr Thr Pro Lys Glu Thr Ala Pro Thr Thr Pro Lys 
                565                 570                 575     
Gly Thr Ala Pro Thr Thr Leu Lys Glu Pro Ala Pro Thr Thr Pro Lys 
            580                 585                 590         
Lys Pro Ala Pro Lys Glu Leu Ala Pro Thr Thr Thr Lys Glu Pro Thr 
        595                 600                 605             
Ser Thr Thr Cys Asp Lys Pro Ala Pro Thr Thr Pro Lys Gly Thr Ala 
    610                 615                 620                 
Pro Thr Thr Pro Lys Glu Pro Ala Pro Thr Thr Pro Lys Glu Pro Ala 
625                 630                 635                 640 
Pro Thr Thr Pro Lys Gly Thr Ala Pro Thr Thr Leu Lys Glu Pro Ala 
                645                 650                 655     
Pro Thr Thr Pro Lys Lys Pro Ala Pro Lys Glu Leu Ala Pro Thr Thr 
            660                 665                 670         
Thr Lys Gly Pro Thr Ser Thr Thr Ser Asp Lys Pro Ala Pro Thr Thr 
        675                 680                 685             
Pro Lys Glu Thr Ala Pro Thr Thr Pro Lys Glu Pro Ala Pro Thr Thr 
    690                 695                 700                 
Pro Lys Lys Pro Ala Pro Thr Thr Pro Glu Thr Pro Pro Pro Thr Thr 
705                 710                 715                 720 
Ser Glu Val Ser Thr Pro Thr Thr Thr Lys Glu Pro Thr Thr Ile His 
                725                 730                 735     
Lys Ser Pro Asp Glu Ser Thr Pro Glu Leu Ser Ala Glu Pro Thr Pro 
            740                 745                 750         
Lys Ala Leu Glu Asn Ser Pro Lys Glu Pro Gly Val Pro Thr Thr Lys 
        755                 760                 765             
Thr Pro Ala Ala Thr Lys Pro Glu Met Thr Thr Thr Ala Lys Asp Lys 
    770                 775                 780                 
Thr Thr Glu Arg Asp Leu Arg Thr Thr Pro Glu Thr Thr Thr Ala Ala 
785                 790                 795                 800 
Pro Lys Met Thr Lys Glu Thr Ala Thr Thr Thr Glu Lys Thr Thr Glu 
                805                 810                 815     
Ser Lys Ile Thr Ala Thr Thr Thr Gln Val Thr Ser Thr Thr Thr Gln 
            820                 825                 830         
Asp Thr Thr Pro Phe Lys Ile Thr Thr Leu Lys Thr Thr Thr Leu Ala 
        835                 840                 845             
Pro Lys Val Thr Thr Thr Lys Lys Thr Ile Thr Thr Thr Glu Ile Met 
    850                 855                 860                 
Asn Lys Pro Glu Glu Thr Ala Lys Pro Lys Asp Arg Ala Thr Asn Ser 
865                 870                 875                 880 
Lys Ala Thr Thr Pro Lys Pro Gln Lys Pro Thr Lys Ala Pro Lys Lys 
                885                 890                 895     
Pro Thr Ser Thr Lys Lys Pro Lys Thr Met Pro Arg Val Arg Lys Pro 
            900                 905                 910         
Lys Thr Thr Pro Thr Pro Arg Lys Met Thr Ser Thr Met Pro Glu Leu 
        915                 920                 925             
Asn Pro Thr Ser Arg Ile Ala Glu Ala Met Leu Gln Thr Thr Thr Arg 
    930                 935                 940                 
Pro Asn Gln Thr Pro Asn Ser Lys Leu Val Glu Val Asn Pro Lys Ser 
945                 950                 955                 960 
Glu Asp Ala Gly Gly Ala Glu Gly Glu Thr Pro His Met Leu Leu Arg 
                965                 970                 975     
Pro His Val Phe Met Pro Glu Val Thr Pro Asp Met Asp Tyr Leu Pro 
            980                 985                 990         
Arg Val Pro Asn Gln Gly Ile Ile Ile Asn Pro Met Leu Ser Asp Glu 
        995                 1000                1005            
Thr Asn Ile Cys Asn Gly Lys Pro Val Asp Gly Leu Thr Thr Leu Arg 
    1010                1015                1020                
Asn Gly Thr Leu Val Ala Phe Arg Gly His Tyr Phe Trp Met Leu Ser 
1025                1030                1035                1040
Pro Phe Ser Pro Pro Ser Pro Ala Arg Arg Ile Thr Glu Val Trp Gly 
                1045                1050                1055    
Ile Pro Ser Pro Ile Asp Thr Val Phe Thr Arg Cys Asn Cys Glu Gly 
            1060                1065                1070        
Lys Thr Phe Phe Phe Lys Asp Ser Gln Tyr Trp Arg Phe Thr Asn Asp 
        1075                1080                1085            
Ile Lys Asp Ala Gly Tyr Pro Lys Pro Ile Phe Lys Gly Phe Gly Gly 
    1090                1095                1100                
Leu Thr Gly Gln Ile Val Ala Ala Leu Ser Thr Ala Lys Tyr Lys Asn 
1105                1110                1115                1120
Trp Pro Glu Ser Val Tyr Phe Phe Lys Arg Gly Gly Ser Ile Gln Gln 
                1125                1130                1135    
Tyr Ile Tyr Lys Gln Glu Pro Val Gln Lys Cys Pro Gly Arg Arg Pro 
            1140                1145                1150        
Ala Leu Asn Tyr Pro Val Tyr Gly Glu Thr Thr Gln Val Arg Arg Arg 
        1155                1160                1165            
Arg Phe Glu Arg Ala Ile Gly Pro Ser Gln Thr His Thr Ile Arg Ile 
    1170                1175                1180                
Gln Tyr Ser Pro Ala Arg Leu Ala Tyr Gln Asp Lys Gly Val Leu His 
1185                1190                1195                1200
Asn Glu Val Lys Val Ser Ile Leu Trp Arg Gly Leu Pro Asn Val Val 
                1205                1210                1215    
Thr Ser Ala Ile Ser Leu Pro Asn Ile Arg Lys Pro Asp Gly Tyr Asp 
            1220                1225                1230        
Tyr Tyr Ala Phe Ser Lys Asp Gln Tyr Tyr Asn Ile Asp Val Pro Ser 
        1235                1240                1245            
Arg Thr Ala Arg Ala Ile Thr Thr Arg Ser Gly Gln Thr Leu Ser Lys 
    1250                1255                1260                
Val Trp Tyr Asn Cys Pro 
1265                1270

<210> 46
<211> 933
<212> PRT
<213> Homo sapiens


<220> 
<223> PRG4 isoform E

<400> 46
Met Ala Trp Lys Thr Leu Pro Ile Tyr Leu Leu Leu Leu Leu Ser Val 
1               5                   10                  15      
Phe Val Ile Gln Gln Val Ser Ser Gln Glu Leu Ser Cys Lys Gly Arg 
            20                  25                  30          
Cys Phe Glu Ser Phe Glu Arg Gly Arg Glu Cys Asp Cys Asp Ala Gln 
        35                  40                  45              
Cys Lys Lys Tyr Asp Lys Cys Cys Pro Asp Tyr Glu Ser Phe Cys Ala 
    50                  55                  60                  
Glu Val His Asn Pro Thr Ser Pro Pro Ser Ser Lys Lys Ala Pro Pro 
65                  70                  75                  80  
Pro Ser Gly Ala Ser Gln Thr Ile Lys Ser Thr Thr Lys Arg Ser Pro 
                85                  90                  95      
Lys Pro Pro Asn Lys Lys Lys Thr Lys Lys Val Ile Glu Ser Glu Glu 
            100                 105                 110         
Ile Thr Glu Glu His Ser Val Ser Glu Asn Gln Glu Ser Ser Ser Ser 
        115                 120                 125             
Ser Ser Ser Ser Ser Ser Ser Ser Thr Ile Arg Lys Ile Lys Ser Ser 
    130                 135                 140                 
Lys Asn Ser Ala Ala Asn Arg Glu Leu Gln Lys Lys Leu Lys Val Lys 
145                 150                 155                 160 
Asp Asn Lys Lys Asn Arg Thr Lys Lys Lys Pro Thr Pro Lys Pro Pro 
                165                 170                 175     
Val Val Asp Glu Ala Gly Ser Gly Leu Asp Asn Gly Asp Phe Lys Val 
            180                 185                 190         
Thr Thr Pro Asp Thr Ser Thr Thr Gln His Asn Lys Val Ser Thr Ser 
        195                 200                 205             
Pro Lys Ile Thr Thr Ala Lys Pro Ile Asn Pro Arg Pro Ser Leu Pro 
    210                 215                 220                 
Pro Asn Ser Asp Thr Ser Lys Glu Thr Ser Leu Thr Val Asn Lys Glu 
225                 230                 235                 240 
Thr Thr Val Glu Thr Lys Glu Thr Thr Thr Thr Asn Lys Gln Thr Ser 
                245                 250                 255     
Thr Asp Gly Lys Glu Lys Thr Thr Ser Ala Lys Glu Thr Gln Ser Ile 
            260                 265                 270         
Glu Lys Thr Ser Ala Lys Asp Leu Ala Pro Thr Ser Lys Val Leu Ala 
        275                 280                 285             
Lys Pro Thr Pro Lys Ala Glu Thr Thr Thr Lys Gly Pro Ala Leu Thr 
    290                 295                 300                 
Thr Pro Lys Glu Pro Thr Pro Thr Thr Pro Lys Glu Pro Ala Ser Thr 
305                 310                 315                 320 
Thr Pro Lys Glu Pro Thr Pro Thr Thr Ile Lys Ser Ala Pro Thr Thr 
                325                 330                 335     
Pro Lys Glu Pro Ala Pro Thr Thr Thr Lys Ser Ala Pro Thr Thr Pro 
            340                 345                 350         
Lys Glu Pro Ala Pro Thr Thr Thr Lys Glu Pro Ala Pro Thr Thr Pro 
        355                 360                 365             
Lys Glu Pro Ala Pro Thr Thr Pro Glu Thr Pro Pro Pro Thr Thr Ser 
    370                 375                 380                 
Glu Val Ser Thr Pro Thr Thr Thr Lys Glu Pro Thr Thr Ile His Lys 
385                 390                 395                 400 
Ser Pro Asp Glu Ser Thr Pro Glu Leu Ser Ala Glu Pro Thr Pro Lys 
                405                 410                 415     
Ala Leu Glu Asn Ser Pro Lys Glu Pro Gly Val Pro Thr Thr Lys Thr 
            420                 425                 430         
Pro Ala Ala Thr Lys Pro Glu Met Thr Thr Thr Ala Lys Asp Lys Thr 
        435                 440                 445             
Thr Glu Arg Asp Leu Arg Thr Thr Pro Glu Thr Thr Thr Ala Ala Pro 
    450                 455                 460                 
Lys Met Thr Lys Glu Thr Ala Thr Thr Thr Glu Lys Thr Thr Glu Ser 
465                 470                 475                 480 
Lys Ile Thr Ala Thr Thr Thr Gln Val Thr Ser Thr Thr Thr Gln Asp 
                485                 490                 495     
Thr Thr Pro Phe Lys Ile Thr Thr Leu Lys Thr Thr Thr Leu Ala Pro 
            500                 505                 510         
Lys Val Thr Thr Thr Lys Lys Thr Ile Thr Thr Thr Glu Ile Met Asn 
        515                 520                 525             
Lys Pro Glu Glu Thr Ala Lys Pro Lys Asp Arg Ala Thr Asn Ser Lys 
    530                 535                 540                 
Ala Thr Thr Pro Lys Pro Gln Lys Pro Thr Lys Ala Pro Lys Lys Pro 
545                 550                 555                 560 
Thr Ser Thr Lys Lys Pro Lys Thr Met Pro Arg Val Arg Lys Pro Lys 
                565                 570                 575     
Thr Thr Pro Thr Pro Arg Lys Met Thr Ser Thr Met Pro Glu Leu Asn 
            580                 585                 590         
Pro Thr Ser Arg Ile Ala Glu Ala Met Leu Gln Thr Thr Thr Arg Pro 
        595                 600                 605             
Asn Gln Thr Pro Asn Ser Lys Leu Val Glu Val Asn Pro Lys Ser Glu 
    610                 615                 620                 
Asp Ala Gly Gly Ala Glu Gly Glu Thr Pro His Met Leu Leu Arg Pro 
625                 630                 635                 640 
His Val Phe Met Pro Glu Val Thr Pro Asp Met Asp Tyr Leu Pro Arg 
                645                 650                 655     
Val Pro Asn Gln Gly Ile Ile Ile Asn Pro Met Leu Ser Asp Glu Thr 
            660                 665                 670         
Asn Ile Cys Asn Gly Lys Pro Val Asp Gly Leu Thr Thr Leu Arg Asn 
        675                 680                 685             
Gly Thr Leu Val Ala Phe Arg Gly His Tyr Phe Trp Met Leu Ser Pro 
    690                 695                 700                 
Phe Ser Pro Pro Ser Pro Ala Arg Arg Ile Thr Glu Val Trp Gly Ile 
705                 710                 715                 720 
Pro Ser Pro Ile Asp Thr Val Phe Thr Arg Cys Asn Cys Glu Gly Lys 
                725                 730                 735     
Thr Phe Phe Phe Lys Asp Ser Gln Tyr Trp Arg Phe Thr Asn Asp Ile 
            740                 745                 750         
Lys Asp Ala Gly Tyr Pro Lys Pro Ile Phe Lys Gly Phe Gly Gly Leu 
        755                 760                 765             
Thr Gly Gln Ile Val Ala Ala Leu Ser Thr Ala Lys Tyr Lys Asn Trp 
    770                 775                 780                 
Pro Glu Ser Val Tyr Phe Phe Lys Arg Gly Gly Ser Ile Gln Gln Tyr 
785                 790                 795                 800 
Ile Tyr Lys Gln Glu Pro Val Gln Lys Cys Pro Gly Arg Arg Pro Ala 
                805                 810                 815     
Leu Asn Tyr Pro Val Tyr Gly Glu Thr Thr Gln Val Arg Arg Arg Arg 
            820                 825                 830         
Phe Glu Arg Ala Ile Gly Pro Ser Gln Thr His Thr Ile Arg Ile Gln 
        835                 840                 845             
Tyr Ser Pro Ala Arg Leu Ala Tyr Gln Asp Lys Gly Val Leu His Asn 
    850                 855                 860                 
Glu Val Lys Val Ser Ile Leu Trp Arg Gly Leu Pro Asn Val Val Thr 
865                 870                 875                 880 
Ser Ala Ile Ser Leu Pro Asn Ile Arg Lys Pro Asp Gly Tyr Asp Tyr 
                885                 890                 895     
Tyr Ala Phe Ser Lys Asp Gln Tyr Tyr Asn Ile Asp Val Pro Ser Arg 
            900                 905                 910         
Thr Ala Arg Ala Ile Thr Thr Arg Ser Gly Gln Thr Leu Ser Lys Val 
        915                 920                 925             
Trp Tyr Asn Cys Pro 
    930             

<210> 47
<211> 1361
<212> PRT
<213> Homo sapiens


<220> 
<223> PRG4 isoform F

<400> 47
Met Ala Trp Lys Thr Leu Pro Ile Tyr Leu Leu Leu Leu Leu Ser Val 
1               5                   10                  15      
Phe Val Ile Gln Gln Val Ser Ser Gln Asp Leu Ser Ser Cys Ala Gly 
            20                  25                  30          
Arg Cys Gly Glu Gly Tyr Ser Arg Asp Ala Thr Cys Asn Cys Asp Tyr 
        35                  40                  45              
Asn Cys Gln His Tyr Met Glu Cys Cys Pro Asp Phe Lys Arg Val Cys 
    50                  55                  60                  
Thr Ala Glu Leu Ser Cys Lys Gly Arg Cys Phe Glu Ser Phe Glu Arg 
65                  70                  75                  80  
Gly Arg Glu Cys Asp Cys Asp Ala Gln Cys Lys Lys Tyr Asp Lys Cys 
                85                  90                  95      
Cys Pro Asp Tyr Glu Ser Phe Cys Ala Glu Val His Asn Pro Thr Ser 
            100                 105                 110         
Pro Pro Ser Ser Lys Lys Ala Pro Pro Pro Ser Gly Ala Ser Gln Thr 
        115                 120                 125             
Ile Lys Ser Thr Thr Lys Arg Ser Pro Lys Pro Pro Asn Lys Lys Lys 
    130                 135                 140                 
Thr Lys Lys Val Ile Glu Ser Glu Glu Ile Thr Glu Val Lys Asp Asn 
145                 150                 155                 160 
Lys Lys Asn Arg Thr Lys Lys Lys Pro Thr Pro Lys Pro Pro Val Val 
                165                 170                 175     
Asp Glu Ala Gly Ser Gly Leu Asp Asn Gly Asp Phe Lys Val Thr Thr 
            180                 185                 190         
Pro Asp Thr Ser Thr Thr Gln His Asn Lys Val Ser Thr Ser Pro Lys 
        195                 200                 205             
Ile Thr Thr Ala Lys Pro Ile Asn Pro Arg Pro Ser Leu Pro Pro Asn 
    210                 215                 220                 
Ser Asp Thr Ser Lys Glu Thr Ser Leu Thr Val Asn Lys Glu Thr Thr 
225                 230                 235                 240 
Val Glu Thr Lys Glu Thr Thr Thr Thr Asn Lys Gln Thr Ser Thr Asp 
                245                 250                 255     
Gly Lys Glu Lys Thr Thr Ser Ala Lys Glu Thr Gln Ser Ile Glu Lys 
            260                 265                 270         
Thr Ser Ala Lys Asp Leu Ala Pro Thr Ser Lys Val Leu Ala Lys Pro 
        275                 280                 285             
Thr Pro Lys Ala Glu Thr Thr Thr Lys Gly Pro Ala Leu Thr Thr Pro 
    290                 295                 300                 
Lys Glu Pro Thr Pro Thr Thr Pro Lys Glu Pro Ala Ser Thr Thr Pro 
305                 310                 315                 320 
Lys Glu Pro Thr Pro Thr Thr Ile Lys Ser Ala Pro Thr Thr Pro Lys 
                325                 330                 335     
Glu Pro Ala Pro Thr Thr Thr Lys Ser Ala Pro Thr Thr Pro Lys Glu 
            340                 345                 350         
Pro Ala Pro Thr Thr Thr Lys Glu Pro Ala Pro Thr Thr Pro Lys Glu 
        355                 360                 365             
Pro Ala Pro Thr Thr Thr Lys Glu Pro Ala Pro Thr Thr Thr Lys Ser 
    370                 375                 380                 
Ala Pro Thr Thr Pro Lys Glu Pro Ala Pro Thr Thr Pro Lys Lys Pro 
385                 390                 395                 400 
Ala Pro Thr Thr Pro Lys Glu Pro Ala Pro Thr Thr Pro Lys Glu Pro 
                405                 410                 415     
Thr Pro Thr Thr Pro Lys Glu Pro Ala Pro Thr Thr Lys Glu Pro Ala 
            420                 425                 430         
Pro Thr Thr Pro Lys Glu Pro Ala Pro Thr Ala Pro Lys Lys Pro Ala 
        435                 440                 445             
Pro Thr Thr Pro Lys Glu Pro Ala Pro Thr Thr Pro Lys Glu Pro Ala 
    450                 455                 460                 
Pro Thr Thr Thr Lys Glu Pro Ser Pro Thr Thr Pro Lys Glu Pro Ala 
465                 470                 475                 480 
Pro Thr Thr Thr Lys Ser Ala Pro Thr Thr Thr Lys Glu Pro Ala Pro 
                485                 490                 495     
Thr Thr Thr Lys Ser Ala Pro Thr Thr Pro Lys Glu Pro Ser Pro Thr 
            500                 505                 510         
Thr Thr Lys Glu Pro Ala Pro Thr Thr Pro Lys Glu Pro Ala Pro Thr 
        515                 520                 525             
Thr Pro Lys Lys Pro Ala Pro Thr Thr Pro Lys Glu Pro Ala Pro Thr 
    530                 535                 540                 
Thr Pro Lys Glu Pro Ala Pro Thr Thr Thr Lys Lys Pro Ala Pro Thr 
545                 550                 555                 560 
Thr Pro Lys Glu Pro Ala Pro Thr Thr Pro Lys Glu Thr Ala Pro Thr 
                565                 570                 575     
Thr Pro Lys Lys Leu Thr Pro Thr Thr Pro Glu Lys Leu Ala Pro Thr 
            580                 585                 590         
Thr Pro Glu Lys Pro Ala Pro Thr Thr Pro Glu Glu Leu Ala Pro Thr 
        595                 600                 605             
Thr Pro Glu Glu Pro Thr Pro Thr Thr Pro Glu Glu Pro Ala Pro Thr 
    610                 615                 620                 
Thr Pro Lys Ala Ala Ala Pro Asn Thr Pro Lys Glu Pro Ala Pro Thr 
625                 630                 635                 640 
Thr Pro Lys Glu Pro Ala Pro Thr Thr Pro Lys Glu Pro Ala Pro Thr 
                645                 650                 655     
Thr Pro Lys Glu Thr Ala Pro Thr Thr Pro Lys Gly Thr Ala Pro Thr 
            660                 665                 670         
Thr Leu Lys Glu Pro Ala Pro Thr Thr Pro Lys Lys Pro Ala Pro Lys 
        675                 680                 685             
Glu Leu Ala Pro Thr Thr Thr Lys Glu Pro Thr Ser Thr Thr Cys Asp 
    690                 695                 700                 
Lys Pro Ala Pro Thr Thr Pro Lys Gly Thr Ala Pro Thr Thr Pro Lys 
705                 710                 715                 720 
Glu Pro Ala Pro Thr Thr Pro Lys Glu Pro Ala Pro Thr Thr Pro Lys 
                725                 730                 735     
Gly Thr Ala Pro Thr Thr Leu Lys Glu Pro Ala Pro Thr Thr Pro Lys 
            740                 745                 750         
Lys Pro Ala Pro Lys Glu Leu Ala Pro Thr Thr Thr Lys Gly Pro Thr 
        755                 760                 765             
Ser Thr Thr Ser Asp Lys Pro Ala Pro Thr Thr Pro Lys Glu Thr Ala 
    770                 775                 780                 
Pro Thr Thr Pro Lys Glu Pro Ala Pro Thr Thr Pro Lys Lys Pro Ala 
785                 790                 795                 800 
Pro Thr Thr Pro Glu Thr Pro Pro Pro Thr Thr Ser Glu Val Ser Thr 
                805                 810                 815     
Pro Thr Thr Thr Lys Glu Pro Thr Thr Ile His Lys Ser Pro Asp Glu 
            820                 825                 830         
Ser Thr Pro Glu Leu Ser Ala Glu Pro Thr Pro Lys Ala Leu Glu Asn 
        835                 840                 845             
Ser Pro Lys Glu Pro Gly Val Pro Thr Thr Lys Thr Pro Ala Ala Thr 
    850                 855                 860                 
Lys Pro Glu Met Thr Thr Thr Ala Lys Asp Lys Thr Thr Glu Arg Asp 
865                 870                 875                 880 
Leu Arg Thr Thr Pro Glu Thr Thr Thr Ala Ala Pro Lys Met Thr Lys 
                885                 890                 895     
Glu Thr Ala Thr Thr Thr Glu Lys Thr Thr Glu Ser Lys Ile Thr Ala 
            900                 905                 910         
Thr Thr Thr Gln Val Thr Ser Thr Thr Thr Gln Asp Thr Thr Pro Phe 
        915                 920                 925             
Lys Ile Thr Thr Leu Lys Thr Thr Thr Leu Ala Pro Lys Val Thr Thr 
    930                 935                 940                 
Thr Lys Lys Thr Ile Thr Thr Thr Glu Ile Met Asn Lys Pro Glu Glu 
945                 950                 955                 960 
Thr Ala Lys Pro Lys Asp Arg Ala Thr Asn Ser Lys Ala Thr Thr Pro 
                965                 970                 975     
Lys Pro Gln Lys Pro Thr Lys Ala Pro Lys Lys Pro Thr Ser Thr Lys 
            980                 985                 990         
Lys Pro Lys Thr Met Pro Arg Val Arg Lys Pro Lys Thr Thr Pro Thr 
        995                 1000                1005            
Pro Arg Lys Met Thr Ser Thr Met Pro Glu Leu Asn Pro Thr Ser Arg 
    1010                1015                1020                
Ile Ala Glu Ala Met Leu Gln Thr Thr Thr Arg Pro Asn Gln Thr Pro 
1025                1030                1035                1040
Asn Ser Lys Leu Val Glu Val Asn Pro Lys Ser Glu Asp Ala Gly Gly 
                1045                1050                1055    
Ala Glu Gly Glu Thr Pro His Met Leu Leu Arg Pro His Val Phe Met 
            1060                1065                1070        
Pro Glu Val Thr Pro Asp Met Asp Tyr Leu Pro Arg Val Pro Asn Gln 
        1075                1080                1085            
Gly Ile Ile Ile Asn Pro Met Leu Ser Asp Glu Thr Asn Ile Cys Asn 
    1090                1095                1100                
Gly Lys Pro Val Asp Gly Leu Thr Thr Leu Arg Asn Gly Thr Leu Val 
1105                1110                1115                1120
Ala Phe Arg Gly His Tyr Phe Trp Met Leu Ser Pro Phe Ser Pro Pro 
                1125                1130                1135    
Ser Pro Ala Arg Arg Ile Thr Glu Val Trp Gly Ile Pro Ser Pro Ile 
            1140                1145                1150        
Asp Thr Val Phe Thr Arg Cys Asn Cys Glu Gly Lys Thr Phe Phe Phe 
        1155                1160                1165            
Lys Asp Ser Gln Tyr Trp Arg Phe Thr Asn Asp Ile Lys Asp Ala Gly 
    1170                1175                1180                
Tyr Pro Lys Pro Ile Phe Lys Gly Phe Gly Gly Leu Thr Gly Gln Ile 
1185                1190                1195                1200
Val Ala Ala Leu Ser Thr Ala Lys Tyr Lys Asn Trp Pro Glu Ser Val 
                1205                1210                1215    
Tyr Phe Phe Lys Arg Gly Gly Ser Ile Gln Gln Tyr Ile Tyr Lys Gln 
            1220                1225                1230        
Glu Pro Val Gln Lys Cys Pro Gly Arg Arg Pro Ala Leu Asn Tyr Pro 
        1235                1240                1245            
Val Tyr Gly Glu Thr Thr Gln Val Arg Arg Arg Arg Phe Glu Arg Ala 
    1250                1255                1260                
Ile Gly Pro Ser Gln Thr His Thr Ile Arg Ile Gln Tyr Ser Pro Ala 
1265                1270                1275                1280
Arg Leu Ala Tyr Gln Asp Lys Gly Val Leu His Asn Glu Val Lys Val 
                1285                1290                1295    
Ser Ile Leu Trp Arg Gly Leu Pro Asn Val Val Thr Ser Ala Ile Ser 
            1300                1305                1310        
Leu Pro Asn Ile Arg Lys Pro Asp Gly Tyr Asp Tyr Tyr Ala Phe Ser 
        1315                1320                1325            
Lys Asp Gln Tyr Tyr Asn Ile Asp Val Pro Ser Arg Thr Ala Arg Ala 
    1330                1335                1340                
Ile Thr Thr Arg Ser Gly Gln Thr Leu Ser Lys Val Trp Tyr Asn Cys 
1345                1350                1355                1360
Pro 
    

<210> 48
<211> 198
<212> PRT
<213> Homo sapiens


<220> 
<223> PRDX2

<400> 48
Met Ala Ser Gly Asn Ala Arg Ile Gly Lys Pro Ala Pro Asp Phe Lys 
1               5                   10                  15      
Ala Thr Ala Val Val Asp Gly Ala Phe Lys Glu Val Lys Leu Ser Asp 
            20                  25                  30          
Tyr Lys Gly Lys Tyr Val Val Leu Phe Phe Tyr Pro Leu Asp Phe Thr 
        35                  40                  45              
Phe Val Cys Pro Thr Glu Ile Ile Ala Phe Ser Asn Arg Ala Glu Asp 
    50                  55                  60                  
Phe Arg Lys Leu Gly Cys Glu Val Leu Gly Val Ser Val Asp Ser Gln 
65                  70                  75                  80  
Phe Thr His Leu Ala Trp Ile Asn Thr Pro Arg Lys Glu Gly Gly Leu 
                85                  90                  95      
Gly Pro Leu Asn Ile Pro Leu Leu Ala Asp Val Thr Arg Arg Leu Ser 
            100                 105                 110         
Glu Asp Tyr Gly Val Leu Lys Thr Asp Glu Gly Ile Ala Tyr Arg Gly 
        115                 120                 125             
Leu Phe Ile Ile Asp Gly Lys Gly Val Leu Arg Gln Ile Thr Val Asn 
    130                 135                 140                 
Asp Leu Pro Val Gly Arg Ser Val Asp Glu Ala Leu Arg Leu Val Gln 
145                 150                 155                 160 
Ala Phe Gln Tyr Thr Asp Glu His Gly Glu Val Cys Pro Ala Gly Trp 
                165                 170                 175     
Lys Pro Gly Ser Asp Thr Ile Lys Pro Asn Val Asp Asp Ser Lys Glu 
            180                 185                 190         
Tyr Phe Ser Lys His Asn 
        195             

<210> 49
<211> 197
<212> PRT
<213> Homo sapiens


<220> 
<223> PRDX2 mature form

<400> 49
Ala Ser Gly Asn Ala Arg Ile Gly Lys Pro Ala Pro Asp Phe Lys Ala 
1               5                   10                  15      
Thr Ala Val Val Asp Gly Ala Phe Lys Glu Val Lys Leu Ser Asp Tyr 
            20                  25                  30          
Lys Gly Lys Tyr Val Val Leu Phe Phe Tyr Pro Leu Asp Phe Thr Phe 
        35                  40                  45              
Val Cys Pro Thr Glu Ile Ile Ala Phe Ser Asn Arg Ala Glu Asp Phe 
    50                  55                  60                  
Arg Lys Leu Gly Cys Glu Val Leu Gly Val Ser Val Asp Ser Gln Phe 
65                  70                  75                  80  
Thr His Leu Ala Trp Ile Asn Thr Pro Arg Lys Glu Gly Gly Leu Gly 
                85                  90                  95      
Pro Leu Asn Ile Pro Leu Leu Ala Asp Val Thr Arg Arg Leu Ser Glu 
            100                 105                 110         
Asp Tyr Gly Val Leu Lys Thr Asp Glu Gly Ile Ala Tyr Arg Gly Leu 
        115                 120                 125             
Phe Ile Ile Asp Gly Lys Gly Val Leu Arg Gln Ile Thr Val Asn Asp 
    130                 135                 140                 
Leu Pro Val Gly Arg Ser Val Asp Glu Ala Leu Arg Leu Val Gln Ala 
145                 150                 155                 160 
Phe Gln Tyr Thr Asp Glu His Gly Glu Val Cys Pro Ala Gly Trp Lys 
                165                 170                 175     
Pro Gly Ser Asp Thr Ile Lys Pro Asn Val Asp Asp Ser Lys Glu Tyr 
            180                 185                 190         
Phe Ser Lys His Asn 
        195         

<210> 50
<211> 142
<212> PRT
<213> Homo sapiens


<220> 
<223> PRDX2 isoform 2

<400> 50
Met Ala Ser Gly Asn Ala Arg Ile Gly Lys Pro Ala Pro Asp Phe Lys 
1               5                   10                  15      
Ala Thr Ala Val Val Asp Gly Ala Phe Lys Glu Val Lys Leu Ser Asp 
            20                  25                  30          
Tyr Lys Gly Lys Tyr Val Val Leu Phe Phe Tyr Pro Leu Asp Phe Thr 
        35                  40                  45              
Phe Val Cys Pro Thr Glu Ile Ile Ala Phe Ser Asn Arg Ala Glu Asp 
    50                  55                  60                  
Phe Arg Lys Leu Gly Cys Glu Val Leu Gly Val Ser Val Asp Ser Gln 
65                  70                  75                  80  
Phe Thr His Leu Ala Trp Tyr Glu Gln Gly Pro Lys Arg Glu Val Ala 
                85                  90                  95      
Ala Lys Leu Thr Pro Ser Gly Pro Ser Ser Val Ala Ser Trp Pro Leu 
            100                 105                 110         
Leu Asn Leu Trp Asn Leu Arg Phe Pro Ile Val Lys Ile Met Glu Thr 
        115                 120                 125             
Leu Pro Pro Lys Ser Leu Arg Met Met Thr Val Ile Ser Ile 
    130                 135                 140         

<210> 51
<211> 1332
<212> PRT
<213> Homo sapiens


<220> 
<223> IL-16

<400> 51
Met Glu Ser His Ser Arg Ala Gly Lys Ser Arg Lys Ser Ala Lys Phe 
1               5                   10                  15      
Arg Ser Ile Ser Arg Ser Leu Met Leu Cys Asn Ala Lys Thr Ser Asp 
            20                  25                  30          
Asp Gly Ser Ser Pro Asp Glu Lys Tyr Pro Asp Pro Phe Glu Ile Ser 
        35                  40                  45              
Leu Ala Gln Gly Lys Glu Gly Ile Phe His Ser Ser Val Gln Leu Ala 
    50                  55                  60                  
Asp Thr Ser Glu Ala Gly Pro Ser Ser Val Pro Asp Leu Ala Leu Ala 
65                  70                  75                  80  
Ser Glu Ala Ala Gln Leu Gln Ala Ala Gly Asn Asp Arg Gly Lys Thr 
                85                  90                  95      
Cys Arg Arg Ile Phe Phe Met Lys Glu Ser Ser Thr Ala Ser Ser Arg 
            100                 105                 110         
Glu Lys Pro Gly Lys Leu Glu Ala Gln Ser Ser Asn Phe Leu Phe Pro 
        115                 120                 125             
Lys Ala Cys His Gln Arg Ala Arg Ser Asn Ser Thr Ser Val Asn Pro 
    130                 135                 140                 
Tyr Cys Thr Arg Glu Ile Asp Phe Pro Met Thr Lys Lys Ser Ala Ala 
145                 150                 155                 160 
Pro Thr Asp Arg Gln Pro Tyr Ser Leu Cys Ser Asn Arg Lys Ser Leu 
                165                 170                 175     
Ser Gln Gln Leu Asp Cys Pro Ala Gly Lys Ala Ala Gly Thr Ser Arg 
            180                 185                 190         
Pro Thr Arg Ser Leu Ser Thr Ala Gln Leu Val Gln Pro Ser Gly Gly 
        195                 200                 205             
Leu Gln Ala Ser Val Ile Ser Asn Ile Val Leu Met Lys Gly Gln Ala 
    210                 215                 220                 
Lys Gly Leu Gly Phe Ser Ile Val Gly Gly Lys Asp Ser Ile Tyr Gly 
225                 230                 235                 240 
Pro Ile Gly Ile Tyr Val Lys Thr Ile Phe Ala Gly Gly Ala Ala Ala 
                245                 250                 255     
Ala Asp Gly Arg Leu Gln Glu Gly Asp Glu Ile Leu Glu Leu Asn Gly 
            260                 265                 270         
Glu Ser Met Ala Gly Leu Thr His Gln Asp Ala Leu Gln Lys Phe Lys 
        275                 280                 285             
Gln Ala Lys Lys Gly Leu Leu Thr Leu Thr Val Arg Thr Arg Leu Thr 
    290                 295                 300                 
Ala Pro Pro Ser Leu Cys Ser His Leu Ser Pro Pro Leu Cys Arg Ser 
305                 310                 315                 320 
Leu Ser Ser Ser Thr Cys Ile Thr Lys Asp Ser Ser Ser Phe Ala Leu 
                325                 330                 335     
Glu Ser Pro Ser Ala Pro Ile Ser Thr Ala Lys Pro Asn Tyr Arg Ile 
            340                 345                 350         
Met Val Glu Val Ser Leu Gln Lys Glu Ala Gly Val Gly Leu Gly Ile 
        355                 360                 365             
Gly Leu Cys Ser Val Pro Tyr Phe Gln Cys Ile Ser Gly Ile Phe Val 
    370                 375                 380                 
His Thr Leu Ser Pro Gly Ser Val Ala His Leu Asp Gly Arg Leu Arg 
385                 390                 395                 400 
Cys Gly Asp Glu Ile Val Glu Ile Ser Asp Ser Pro Val His Cys Leu 
                405                 410                 415     
Thr Leu Asn Glu Val Tyr Thr Ile Leu Ser His Cys Asp Pro Gly Pro 
            420                 425                 430         
Val Pro Ile Ile Val Ser Arg His Pro Asp Pro Gln Val Ser Glu Gln 
        435                 440                 445             
Gln Leu Lys Glu Ala Val Ala Gln Ala Val Glu Asn Thr Lys Phe Gly 
    450                 455                 460                 
Lys Glu Arg His Gln Trp Ser Leu Glu Gly Val Lys Arg Leu Glu Ser 
465                 470                 475                 480 
Ser Trp His Gly Arg Pro Thr Leu Glu Lys Glu Arg Glu Lys Asn Ser 
                485                 490                 495     
Ala Pro Pro His Arg Arg Ala Gln Lys Val Met Ile Arg Ser Ser Ser 
            500                 505                 510         
Asp Ser Ser Tyr Met Ser Gly Ser Pro Gly Gly Ser Pro Gly Ser Gly 
        515                 520                 525             
Ser Ala Glu Lys Pro Ser Ser Asp Val Asp Ile Ser Thr His Ser Pro 
    530                 535                 540                 
Ser Leu Pro Leu Ala Arg Glu Pro Val Val Leu Ser Ile Ala Ser Ser 
545                 550                 555                 560 
Arg Leu Pro Gln Glu Ser Pro Pro Leu Pro Glu Ser Arg Asp Ser His 
                565                 570                 575     
Pro Pro Leu Arg Leu Lys Lys Ser Phe Glu Ile Leu Val Arg Lys Pro 
            580                 585                 590         
Met Ser Ser Lys Pro Lys Pro Pro Pro Arg Lys Tyr Phe Lys Ser Asp 
        595                 600                 605             
Ser Asp Pro Gln Lys Ser Leu Glu Glu Arg Glu Asn Ser Ser Cys Ser 
    610                 615                 620                 
Ser Gly His Thr Pro Pro Thr Cys Gly Gln Glu Ala Arg Glu Leu Leu 
625                 630                 635                 640 
Pro Leu Leu Leu Pro Gln Glu Asp Thr Ala Gly Arg Ser Pro Ser Ala 
                645                 650                 655     
Ser Ala Gly Cys Pro Gly Pro Gly Ile Gly Pro Gln Thr Lys Ser Ser 
            660                 665                 670         
Thr Glu Gly Glu Pro Gly Trp Arg Arg Ala Ser Pro Val Thr Gln Thr 
        675                 680                 685             
Ser Pro Ile Lys His Pro Leu Leu Lys Arg Gln Ala Arg Met Asp Tyr 
    690                 695                 700                 
Ser Phe Asp Thr Thr Ala Glu Asp Pro Trp Val Arg Ile Ser Asp Cys 
705                 710                 715                 720 
Ile Lys Asn Leu Phe Ser Pro Ile Met Ser Glu Asn His Gly His Met 
                725                 730                 735     
Pro Leu Gln Pro Asn Ala Ser Leu Asn Glu Glu Glu Gly Thr Gln Gly 
            740                 745                 750         
His Pro Asp Gly Thr Pro Pro Lys Leu Asp Thr Ala Asn Gly Thr Pro 
        755                 760                 765             
Lys Val Tyr Lys Ser Ala Asp Ser Ser Thr Val Lys Lys Gly Pro Pro 
    770                 775                 780                 
Val Ala Pro Lys Pro Ala Trp Phe Arg Gln Ser Leu Lys Gly Leu Arg 
785                 790                 795                 800 
Asn Arg Ala Ser Asp Pro Arg Gly Leu Pro Asp Pro Ala Leu Ser Thr 
                805                 810                 815     
Gln Pro Ala Pro Ala Ser Arg Glu His Leu Gly Ser His Ile Arg Ala 
            820                 825                 830         
Ser Ser Ser Ser Ser Ser Ile Arg Gln Arg Ile Ser Ser Phe Glu Thr 
        835                 840                 845             
Phe Gly Ser Ser Gln Leu Pro Asp Lys Gly Ala Gln Arg Leu Ser Leu 
    850                 855                 860                 
Gln Pro Ser Ser Gly Glu Ala Ala Lys Pro Leu Gly Lys His Glu Glu 
865                 870                 875                 880 
Gly Arg Phe Ser Gly Leu Leu Gly Arg Gly Ala Ala Pro Thr Leu Val 
                885                 890                 895     
Pro Gln Gln Pro Glu Gln Val Leu Ser Ser Gly Ser Pro Ala Ala Ser 
            900                 905                 910         
Glu Ala Arg Asp Pro Gly Val Ser Glu Ser Pro Pro Pro Gly Arg Gln 
        915                 920                 925             
Pro Asn Gln Lys Thr Leu Pro Pro Gly Pro Asp Pro Leu Leu Arg Leu 
    930                 935                 940                 
Leu Ser Thr Gln Ala Glu Glu Ser Gln Gly Pro Val Leu Lys Met Pro 
945                 950                 955                 960 
Ser Gln Arg Ala Arg Ser Phe Pro Leu Thr Arg Ser Gln Ser Cys Glu 
                965                 970                 975     
Thr Lys Leu Leu Asp Glu Lys Thr Ser Lys Leu Tyr Ser Ile Ser Ser 
            980                 985                 990         
Gln Val Ser Ser Ala Val Met Lys Ser Leu Leu Cys Leu Pro Ser Ser 
        995                 1000                1005            
Ile Ser Cys Ala Gln Thr Pro Cys Ile Pro Lys Glu Gly Ala Ser Pro 
    1010                1015                1020                
Thr Ser Ser Ser Asn Glu Asp Ser Ala Ala Asn Gly Ser Ala Glu Thr 
1025                1030                1035                1040
Ser Ala Leu Asp Thr Gly Phe Ser Leu Asn Leu Ser Glu Leu Arg Glu 
                1045                1050                1055    
Tyr Thr Glu Gly Leu Thr Glu Ala Lys Glu Asp Asp Asp Gly Asp His 
            1060                1065                1070        
Ser Ser Leu Gln Ser Gly Gln Ser Val Ile Ser Leu Leu Ser Ser Glu 
        1075                1080                1085            
Glu Leu Lys Lys Leu Ile Glu Glu Val Lys Val Leu Asp Glu Ala Thr 
    1090                1095                1100                
Leu Lys Gln Leu Asp Gly Ile His Val Thr Ile Leu His Lys Glu Glu 
1105                1110                1115                1120
Gly Ala Gly Leu Gly Phe Ser Leu Ala Gly Gly Ala Asp Leu Glu Asn 
                1125                1130                1135    
Lys Val Ile Thr Val His Arg Val Phe Pro Asn Gly Leu Ala Ser Gln 
            1140                1145                1150        
Glu Gly Thr Ile Gln Lys Gly Asn Glu Val Leu Ser Ile Asn Gly Lys 
        1155                1160                1165            
Ser Leu Lys Gly Thr Thr His His Asp Ala Leu Ala Ile Leu Arg Gln 
    1170                1175                1180                
Ala Arg Glu Pro Arg Gln Ala Val Ile Val Thr Arg Lys Leu Thr Pro 
1185                1190                1195                1200
Glu Ala Met Pro Asp Leu Asn Ser Ser Thr Asp Ser Ala Ala Ser Ala 
                1205                1210                1215    
Ser Ala Ala Ser Asp Val Ser Val Glu Ser Thr Ala Glu Ala Thr Val 
            1220                1225                1230        
Cys Thr Val Thr Leu Glu Lys Met Ser Ala Gly Leu Gly Phe Ser Leu 
        1235                1240                1245            
Glu Gly Gly Lys Gly Ser Leu His Gly Asp Lys Pro Leu Thr Ile Asn 
    1250                1255                1260                
Arg Ile Phe Lys Gly Ala Ala Ser Glu Gln Ser Glu Thr Val Gln Pro 
1265                1270                1275                1280
Gly Asp Glu Ile Leu Gln Leu Gly Gly Thr Ala Met Gln Gly Leu Thr 
                1285                1290                1295    
Arg Phe Glu Ala Trp Asn Ile Ile Lys Ala Leu Pro Asp Gly Pro Val 
            1300                1305                1310        
Thr Ile Val Ile Arg Arg Lys Ser Leu Gln Ser Lys Glu Thr Thr Ala 
        1315                1320                1325            
Ala Gly Asp Ser 
    1330        

<210> 52
<211> 121
<212> PRT
<213> Homo sapiens


<220> 
<223> IL-16 mature form

<400> 52
Ser Ala Ala Ser Ala Ser Ala Ala Ser Asp Val Ser Val Glu Ser Thr 
1               5                   10                  15      
Ala Glu Ala Thr Val Cys Thr Val Thr Leu Glu Lys Met Ser Ala Gly 
            20                  25                  30          
Leu Gly Phe Ser Leu Glu Gly Gly Lys Gly Ser Leu His Gly Asp Lys 
        35                  40                  45              
Pro Leu Thr Ile Asn Arg Ile Phe Lys Gly Ala Ala Ser Glu Gln Ser 
    50                  55                  60                  
Glu Thr Val Gln Pro Gly Asp Glu Ile Leu Gln Leu Gly Gly Thr Ala 
65                  70                  75                  80  
Met Gln Gly Leu Thr Arg Phe Glu Ala Trp Asn Ile Ile Lys Ala Leu 
                85                  90                  95      
Pro Asp Gly Pro Val Thr Ile Val Ile Arg Arg Lys Ser Leu Gln Ser 
            100                 105                 110         
Lys Glu Thr Thr Ala Ala Gly Asp Ser 
        115                 120     

<210> 53
<211> 1331
<212> PRT
<213> Homo sapiens


<220> 
<223> IL-16 isoform 2

<400> 53
Met Glu Ser His Ser Arg Ala Gly Lys Ser Arg Lys Ser Ala Lys Phe 
1               5                   10                  15      
Arg Ser Ile Ser Arg Ser Leu Met Leu Cys Asn Ala Lys Thr Ser Asp 
            20                  25                  30          
Asp Gly Ser Ser Pro Asp Glu Lys Tyr Pro Asp Pro Phe Glu Ile Ser 
        35                  40                  45              
Leu Ala Gln Gly Lys Glu Gly Ile Phe His Ser Ser Val Gln Leu Ala 
    50                  55                  60                  
Asp Thr Ser Glu Ala Gly Pro Ser Ser Val Pro Asp Leu Ala Leu Ala 
65                  70                  75                  80  
Ser Glu Ala Ala Gln Leu Gln Ala Ala Gly Asn Asp Arg Gly Lys Thr 
                85                  90                  95      
Cys Arg Arg Ile Phe Phe Met Lys Glu Ser Ser Thr Ala Ser Ser Arg 
            100                 105                 110         
Glu Lys Pro Gly Lys Leu Glu Ala Gln Ser Ser Asn Phe Leu Phe Pro 
        115                 120                 125             
Lys Ala Cys His Gln Arg Ala Arg Ser Asn Ser Thr Ser Val Asn Pro 
    130                 135                 140                 
Tyr Cys Thr Arg Glu Ile Asp Phe Pro Met Thr Lys Lys Ser Ala Ala 
145                 150                 155                 160 
Pro Thr Asp Arg Gln Pro Tyr Ser Leu Cys Ser Asn Arg Lys Ser Leu 
                165                 170                 175     
Ser Gln Gln Leu Asp Cys Pro Ala Gly Lys Ala Ala Gly Thr Ser Arg 
            180                 185                 190         
Pro Thr Arg Ser Leu Ser Thr Ala Gln Leu Val Gln Pro Ser Gly Gly 
        195                 200                 205             
Leu Gln Ala Ser Val Ile Ser Asn Ile Val Leu Met Lys Gly Gln Ala 
    210                 215                 220                 
Lys Gly Leu Gly Phe Ser Ile Val Gly Gly Lys Asp Ser Ile Tyr Gly 
225                 230                 235                 240 
Pro Ile Gly Ile Tyr Val Lys Thr Ile Phe Ala Gly Gly Ala Ala Ala 
                245                 250                 255     
Ala Asp Gly Arg Leu Gln Glu Gly Asp Glu Ile Leu Glu Leu Asn Gly 
            260                 265                 270         
Glu Ser Met Ala Gly Leu Thr His Gln Asp Ala Leu Gln Lys Phe Lys 
        275                 280                 285             
Gln Ala Lys Lys Gly Leu Leu Thr Leu Thr Val Arg Thr Arg Leu Thr 
    290                 295                 300                 
Ala Pro Pro Ser Leu Cys Ser His Leu Ser Pro Pro Leu Cys Arg Ser 
305                 310                 315                 320 
Leu Ser Ser Ser Thr Cys Ile Thr Lys Asp Ser Ser Ser Phe Ala Leu 
                325                 330                 335     
Glu Ser Pro Ser Ala Pro Ile Ser Thr Ala Lys Pro Asn Tyr Arg Ile 
            340                 345                 350         
Met Val Glu Val Ser Leu Gln Lys Glu Ala Gly Val Gly Leu Gly Ile 
        355                 360                 365             
Gly Leu Cys Ser Val Pro Tyr Phe Gln Cys Ile Ser Gly Ile Phe Val 
    370                 375                 380                 
His Thr Leu Ser Pro Gly Ser Val Ala His Leu Asp Gly Arg Leu Arg 
385                 390                 395                 400 
Cys Gly Asp Glu Ile Val Glu Ile Ser Asp Ser Pro Val His Cys Leu 
                405                 410                 415     
Thr Leu Asn Glu Val Tyr Thr Ile Leu Ser His Cys Asp Pro Gly Pro 
            420                 425                 430         
Val Pro Ile Ile Val Ser Arg His Pro Asp Pro Gln Val Ser Glu Gln 
        435                 440                 445             
Gln Leu Lys Glu Ala Val Ala Gln Ala Val Glu Asn Thr Lys Phe Gly 
    450                 455                 460                 
Lys Glu Arg His Gln Trp Ser Leu Glu Gly Val Lys Arg Leu Glu Ser 
465                 470                 475                 480 
Ser Trp His Gly Arg Pro Thr Leu Glu Lys Glu Arg Glu Lys Asn Ser 
                485                 490                 495     
Ala Pro Pro His Arg Arg Ala Gln Lys Val Met Ile Arg Ser Ser Ser 
            500                 505                 510         
Asp Ser Ser Tyr Met Ser Gly Ser Pro Gly Gly Ser Pro Gly Ser Gly 
        515                 520                 525             
Ser Ala Glu Lys Pro Ser Ser Asp Val Asp Ile Ser Thr His Ser Pro 
    530                 535                 540                 
Ser Leu Pro Leu Ala Arg Glu Pro Val Val Leu Ser Ile Ala Ser Ser 
545                 550                 555                 560 
Arg Leu Pro Gln Glu Ser Pro Pro Leu Pro Glu Ser Arg Asp Ser His 
                565                 570                 575     
Pro Pro Leu Arg Leu Lys Lys Ser Phe Glu Ile Leu Val Arg Lys Pro 
            580                 585                 590         
Met Ser Ser Lys Pro Lys Pro Pro Pro Arg Lys Tyr Phe Lys Ser Asp 
        595                 600                 605             
Ser Asp Pro Gln Lys Ser Leu Glu Glu Arg Glu Asn Ser Ser Cys Ser 
    610                 615                 620                 
Ser Gly His Thr Pro Pro Thr Cys Gly Gln Glu Ala Arg Glu Leu Leu 
625                 630                 635                 640 
Pro Leu Leu Leu Pro Gln Glu Asp Thr Ala Gly Arg Ser Pro Ser Ala 
                645                 650                 655     
Ser Ala Gly Cys Pro Gly Pro Gly Ile Gly Pro Gln Thr Lys Ser Ser 
            660                 665                 670         
Thr Glu Gly Glu Pro Gly Trp Arg Arg Ala Ser Pro Val Thr Gln Thr 
        675                 680                 685             
Ser Pro Ile Lys His Pro Leu Leu Lys Arg Gln Ala Arg Met Asp Tyr 
    690                 695                 700                 
Ser Phe Asp Thr Thr Ala Glu Asp Pro Trp Val Arg Ile Ser Asp Cys 
705                 710                 715                 720 
Ile Lys Asn Leu Phe Ser Pro Ile Met Ser Glu Asn His Gly His Met 
                725                 730                 735     
Pro Leu Gln Pro Asn Ala Ser Leu Asn Glu Glu Glu Gly Thr Gln Gly 
            740                 745                 750         
His Pro Asp Gly Thr Pro Pro Lys Leu Asp Thr Ala Asn Gly Thr Pro 
        755                 760                 765             
Lys Val Tyr Lys Ser Ala Asp Ser Ser Thr Val Lys Lys Gly Pro Pro 
    770                 775                 780                 
Val Ala Pro Lys Pro Ala Trp Phe Arg Gln Ser Leu Lys Gly Leu Arg 
785                 790                 795                 800 
Asn Arg Ala Ser Asp Pro Arg Gly Leu Pro Asp Pro Ala Leu Ser Thr 
                805                 810                 815     
Gln Pro Ala Pro Ala Ser Arg Glu His Leu Gly Ser His Ile Arg Ala 
            820                 825                 830         
Ser Ser Ser Ser Ser Ser Ile Arg Gln Arg Ile Ser Ser Phe Glu Thr 
        835                 840                 845             
Phe Gly Ser Ser Gln Leu Pro Asp Lys Gly Ala Gln Arg Leu Ser Leu 
    850                 855                 860                 
Gln Pro Ser Ser Gly Glu Ala Ala Lys Pro Leu Gly Lys His Glu Glu 
865                 870                 875                 880 
Gly Arg Phe Ser Gly Leu Leu Gly Arg Gly Ala Ala Pro Thr Leu Val 
                885                 890                 895     
Pro Gln Gln Pro Glu Gln Val Leu Ser Ser Gly Ser Pro Ala Ala Ser 
            900                 905                 910         
Glu Ala Arg Asp Pro Gly Val Ser Glu Ser Pro Pro Pro Gly Arg Gln 
        915                 920                 925             
Pro Asn Gln Lys Thr Leu Pro Pro Gly Pro Asp Pro Leu Leu Arg Leu 
    930                 935                 940                 
Leu Ser Thr Gln Ala Glu Glu Ser Gln Gly Pro Val Leu Lys Met Pro 
945                 950                 955                 960 
Ser Gln Arg Ala Arg Ser Phe Pro Leu Thr Arg Ser Gln Ser Cys Glu 
                965                 970                 975     
Thr Lys Leu Leu Asp Glu Lys Thr Ser Lys Leu Tyr Ser Ile Ser Ser 
            980                 985                 990         
Gln Val Ser Ser Ala Val Met Lys Ser Leu Leu Cys Leu Pro Ser Ser 
        995                 1000                1005            
Ile Ser Cys Ala Gln Thr Pro Cys Ile Pro Lys Glu Gly Ala Ser Pro 
    1010                1015                1020                
Thr Ser Ser Ser Asn Glu Asp Ser Ala Ala Asn Gly Ser Ala Glu Thr 
1025                1030                1035                1040
Ser Ala Leu Asp Thr Gly Phe Ser Leu Asn Leu Ser Glu Leu Arg Glu 
                1045                1050                1055    
Tyr Thr Glu Gly Leu Thr Glu Ala Lys Glu Asp Asp Asp Gly Asp His 
            1060                1065                1070        
Ser Ser Leu Gln Ser Gly Gln Ser Val Ile Ser Leu Leu Ser Ser Glu 
        1075                1080                1085            
Glu Leu Lys Lys Leu Ile Glu Glu Val Lys Val Leu Asp Glu Ala Thr 
    1090                1095                1100                
Leu Lys Gln Leu Asp Gly Ile His Val Thr Ile Leu His Lys Glu Glu 
1105                1110                1115                1120
Gly Ala Gly Leu Gly Phe Ser Leu Ala Gly Gly Ala Asp Leu Glu Asn 
                1125                1130                1135    
Lys Val Ile Thr Val His Arg Val Phe Pro Asn Gly Leu Ala Ser Gln 
            1140                1145                1150        
Glu Gly Thr Ile Gln Lys Gly Asn Glu Val Leu Ser Ile Asn Gly Lys 
        1155                1160                1165            
Ser Leu Lys Gly Thr Thr His His Asp Ala Leu Ala Ile Leu Arg Gln 
    1170                1175                1180                
Ala Arg Glu Pro Arg Gln Ala Val Ile Val Thr Arg Lys Leu Thr Pro 
1185                1190                1195                1200
Glu Ala Met Pro Asp Leu Asn Ser Ser Thr Asp Ser Ala Ala Ser Ala 
                1205                1210                1215    
Ser Ala Ala Ser Asp Val Ser Val Glu Ser Thr Glu Ala Thr Val Cys 
            1220                1225                1230        
Thr Val Thr Leu Glu Lys Met Ser Ala Gly Leu Gly Phe Ser Leu Glu 
        1235                1240                1245            
Gly Gly Lys Gly Ser Leu His Gly Asp Lys Pro Leu Thr Ile Asn Arg 
    1250                1255                1260                
Ile Phe Lys Gly Ala Ala Ser Glu Gln Ser Glu Thr Val Gln Pro Gly 
1265                1270                1275                1280
Asp Glu Ile Leu Gln Leu Gly Gly Thr Ala Met Gln Gly Leu Thr Arg 
                1285                1290                1295    
Phe Glu Ala Trp Asn Ile Ile Lys Ala Leu Pro Asp Gly Pro Val Thr 
            1300                1305                1310        
Ile Val Ile Arg Arg Lys Ser Leu Gln Ser Lys Glu Thr Thr Ala Ala 
        1315                1320                1325            
Gly Asp Ser 
    1330    

<210> 54
<211> 631
<212> PRT
<213> Homo sapiens


<220> 
<223> IL-16 isoform 3

<400> 54
Met Asp Tyr Ser Phe Asp Thr Thr Ala Glu Asp Pro Trp Val Arg Ile 
1               5                   10                  15      
Ser Asp Cys Ile Lys Asn Leu Phe Ser Pro Ile Met Ser Glu Asn His 
            20                  25                  30          
Gly His Met Pro Leu Gln Pro Asn Ala Ser Leu Asn Glu Glu Glu Gly 
        35                  40                  45              
Thr Gln Gly His Pro Asp Gly Thr Pro Pro Lys Leu Asp Thr Ala Asn 
    50                  55                  60                  
Gly Thr Pro Lys Val Tyr Lys Ser Ala Asp Ser Ser Thr Val Lys Lys 
65                  70                  75                  80  
Gly Pro Pro Val Ala Pro Lys Pro Ala Trp Phe Arg Gln Ser Leu Lys 
                85                  90                  95      
Gly Leu Arg Asn Arg Ala Ser Asp Pro Arg Gly Leu Pro Asp Pro Ala 
            100                 105                 110         
Leu Ser Thr Gln Pro Ala Pro Ala Ser Arg Glu His Leu Gly Ser His 
        115                 120                 125             
Ile Arg Ala Ser Ser Ser Ser Ser Ser Ile Arg Gln Arg Ile Ser Ser 
    130                 135                 140                 
Phe Glu Thr Phe Gly Ser Ser Gln Leu Pro Asp Lys Gly Ala Gln Arg 
145                 150                 155                 160 
Leu Ser Leu Gln Pro Ser Ser Gly Glu Ala Ala Lys Pro Leu Gly Lys 
                165                 170                 175     
His Glu Glu Gly Arg Phe Ser Gly Leu Leu Gly Arg Gly Ala Ala Pro 
            180                 185                 190         
Thr Leu Val Pro Gln Gln Pro Glu Gln Val Leu Ser Ser Gly Ser Pro 
        195                 200                 205             
Ala Ala Ser Glu Ala Arg Asp Pro Gly Val Ser Glu Ser Pro Pro Pro 
    210                 215                 220                 
Gly Arg Gln Pro Asn Gln Lys Thr Leu Pro Pro Gly Pro Asp Pro Leu 
225                 230                 235                 240 
Leu Arg Leu Leu Ser Thr Gln Ala Glu Glu Ser Gln Gly Pro Val Leu 
                245                 250                 255     
Lys Met Pro Ser Gln Arg Ala Arg Ser Phe Pro Leu Thr Arg Ser Gln 
            260                 265                 270         
Ser Cys Glu Thr Lys Leu Leu Asp Glu Lys Thr Ser Lys Leu Tyr Ser 
        275                 280                 285             
Ile Ser Ser Gln Val Ser Ser Ala Val Met Lys Ser Leu Leu Cys Leu 
    290                 295                 300                 
Pro Ser Ser Ile Ser Cys Ala Gln Thr Pro Cys Ile Pro Lys Glu Gly 
305                 310                 315                 320 
Ala Ser Pro Thr Ser Ser Ser Asn Glu Asp Ser Ala Ala Asn Gly Ser 
                325                 330                 335     
Ala Glu Thr Ser Ala Leu Asp Thr Gly Phe Ser Leu Asn Leu Ser Glu 
            340                 345                 350         
Leu Arg Glu Tyr Thr Glu Gly Leu Thr Glu Ala Lys Glu Asp Asp Asp 
        355                 360                 365             
Gly Asp His Ser Ser Leu Gln Ser Gly Gln Ser Val Ile Ser Leu Leu 
    370                 375                 380                 
Ser Ser Glu Glu Leu Lys Lys Leu Ile Glu Glu Val Lys Val Leu Asp 
385                 390                 395                 400 
Glu Ala Thr Leu Lys Gln Leu Asp Gly Ile His Val Thr Ile Leu His 
                405                 410                 415     
Lys Glu Glu Gly Ala Gly Leu Gly Phe Ser Leu Ala Gly Gly Ala Asp 
            420                 425                 430         
Leu Glu Asn Lys Val Ile Thr Val His Arg Val Phe Pro Asn Gly Leu 
        435                 440                 445             
Ala Ser Gln Glu Gly Thr Ile Gln Lys Gly Asn Glu Val Leu Ser Ile 
    450                 455                 460                 
Asn Gly Lys Ser Leu Lys Gly Thr Thr His His Asp Ala Leu Ala Ile 
465                 470                 475                 480 
Leu Arg Gln Ala Arg Glu Pro Arg Gln Ala Val Ile Val Thr Arg Lys 
                485                 490                 495     
Leu Thr Pro Glu Ala Met Pro Asp Leu Asn Ser Ser Thr Asp Ser Ala 
            500                 505                 510         
Ala Ser Ala Ser Ala Ala Ser Asp Val Ser Val Glu Ser Thr Ala Glu 
        515                 520                 525             
Ala Thr Val Cys Thr Val Thr Leu Glu Lys Met Ser Ala Gly Leu Gly 
    530                 535                 540                 
Phe Ser Leu Glu Gly Gly Lys Gly Ser Leu His Gly Asp Lys Pro Leu 
545                 550                 555                 560 
Thr Ile Asn Arg Ile Phe Lys Gly Ala Ala Ser Glu Gln Ser Glu Thr 
                565                 570                 575     
Val Gln Pro Gly Asp Glu Ile Leu Gln Leu Gly Gly Thr Ala Met Gln 
            580                 585                 590         
Gly Leu Thr Arg Phe Glu Ala Trp Asn Ile Ile Lys Ala Leu Pro Asp 
        595                 600                 605             
Gly Pro Val Thr Ile Val Ile Arg Arg Lys Ser Leu Gln Ser Lys Glu 
    610                 615                 620                 
Thr Thr Ala Ala Gly Asp Ser 
625                 630     

<210> 55
<211> 560
<212> PRT
<213> Homo sapiens


<220> 
<223> IL-16 isoform 4

<400> 55
Met Asp Tyr Ser Phe Asp Thr Thr Ala Glu Asp Pro Trp Val Arg Ile 
1               5                   10                  15      
Ser Asp Cys Ile Lys Asn Leu Phe Ser Pro Ile Met Ser Glu Asn His 
            20                  25                  30          
Gly His Met Pro Leu Gln Pro Asn Ala Ser Leu Asn Glu Glu Glu Gly 
        35                  40                  45              
Thr Gln Gly His Pro Asp Gly Thr Pro Pro Lys Leu Asp Thr Ala Asn 
    50                  55                  60                  
Gly Thr Pro Lys Val Tyr Lys Ser Ala Asp Ser Ser Thr Val Lys Lys 
65                  70                  75                  80  
Gly Pro Pro Val Ala Pro Lys Pro Ala Trp Phe Arg Gln Ser Leu Lys 
                85                  90                  95      
Gly Leu Arg Asn Arg Ala Ser Asp Pro Arg Gly Leu Pro Asp Pro Ala 
            100                 105                 110         
Leu Ser Thr Gln Pro Ala Pro Ala Ser Arg Glu His Leu Gly Ser His 
        115                 120                 125             
Ile Arg Ala Ser Ser Ser Ser Ser Ser Ile Arg Gln Arg Ile Ser Ser 
    130                 135                 140                 
Phe Glu Thr Phe Gly Ser Ser Gln Leu Pro Asp Lys Gly Ala Gln Arg 
145                 150                 155                 160 
Leu Ser Leu Gln Pro Ser Ser Gly Glu Ala Ala Lys Pro Leu Gly Lys 
                165                 170                 175     
His Glu Glu Gly Arg Phe Ser Gly Leu Leu Gly Arg Gly Ala Ala Pro 
            180                 185                 190         
Thr Leu Val Pro Gln Gln Pro Glu Gln Val Leu Ser Ser Gly Ser Pro 
        195                 200                 205             
Ala Ala Ser Glu Ala Arg Asp Pro Gly Val Ser Glu Ser Pro Pro Pro 
    210                 215                 220                 
Gly Arg Gln Pro Asn Gln Lys Thr Leu Pro Pro Gly Pro Asp Pro Leu 
225                 230                 235                 240 
Leu Arg Leu Leu Ser Thr Gln Ala Glu Glu Ser Gln Gly Pro Val Leu 
                245                 250                 255     
Lys Met Pro Ser Gln Arg Ala Arg Ser Phe Pro Leu Thr Arg Ser Gln 
            260                 265                 270         
Ser Cys Glu Thr Lys Leu Leu Asp Glu Lys Thr Ser Lys Leu Tyr Ser 
        275                 280                 285             
Ile Ser Ser Gln Val Ser Ser Ala Val Met Lys Ser Leu Leu Cys Leu 
    290                 295                 300                 
Pro Ser Ser Ile Ser Cys Ala Gln Thr Pro Cys Ile Pro Lys Glu Gly 
305                 310                 315                 320 
Ala Ser Pro Thr Ser Ser Ser Asn Glu Asp Ser Ala Ala Asn Gly Ser 
                325                 330                 335     
Ala Glu Thr Ser Ala Leu Asp Thr Gly Phe Ser Leu Asn Leu Ser Glu 
            340                 345                 350         
Leu Arg Glu Tyr Thr Glu Gly Leu Thr Glu Ala Lys Glu Asp Asp Asp 
        355                 360                 365             
Gly Asp His Ser Ser Leu Gln Ser Gly Gln Ser Val Ile Ser Leu Leu 
    370                 375                 380                 
Ser Ser Glu Glu Leu Lys Lys Leu Ile Glu Glu Val Lys Val Leu Asp 
385                 390                 395                 400 
Glu Ala Thr Leu Lys Gln Leu Asp Gly Ile His Val Thr Ile Leu His 
                405                 410                 415     
Lys Glu Glu Gly Ala Gly Leu Gly Phe Ser Leu Ala Gly Gly Ala Asp 
            420                 425                 430         
Leu Glu Asn Lys Val Ile Thr Val His Arg Val Phe Pro Asn Gly Leu 
        435                 440                 445             
Ala Ser Gln Glu Gly Thr Ile Gln Lys Gly Asn Glu Val Leu Ser Ile 
    450                 455                 460                 
Asn Gly Lys Ser Leu Lys Gly Thr Thr His His Asp Ala Leu Ala Ile 
465                 470                 475                 480 
Leu Arg Gln Ala Arg Glu Pro Arg Gln Ala Val Ile Val Thr Arg Lys 
                485                 490                 495     
Leu Thr Pro Glu Ala Met Pro Asp Leu Asn Ser Ser Thr Asp Ser Ala 
            500                 505                 510         
Ala Ser Ala Ser Ala Ala Ser Asp Val Ser Val Glu Ser Thr Glu Ala 
        515                 520                 525             
Thr Val Cys Thr Val Thr Leu Glu Asp Val Gly Arg Ala Gly Leu Gln 
    530                 535                 540                 
Pro Gly Arg Arg Glu Gly Leu Pro Thr Arg Arg Gln Ala Ser His His 
545                 550                 555                 560 




