                         SEQUENCE LISTING

<110>  Sinai Health System
 
<120>  ALLOGRAFT TOLERANCE WITHOUT THE NEED FOR SYSTEMIC IMMUNE 
       SUPPRESSION

<130>  PAT 89576W-90

<150>  US 62/666,626
<151>  2018-05-03

<150>  US 62/518,151
<151>  2017-06-12

<160>  17    

<170>  PatentIn version 3.5

<210>  1
<211>  133
<212>  PRT
<213>  Mus musculus

<400>  1

Met Ala Gln Met Met Thr Leu Ser Leu Leu Ser Leu Val Leu Ala Leu 
1               5                   10                  15      


Cys Ile Pro Trp Thr Gln Gly Ser Asp Gly Gly Gly Gln Asp Cys Cys 
            20                  25                  30          


Leu Lys Tyr Ser Gln Lys Lys Ile Pro Tyr Ser Ile Val Arg Gly Tyr 
        35                  40                  45              


Arg Lys Gln Glu Pro Ser Leu Gly Cys Pro Ile Pro Ala Ile Leu Phe 
    50                  55                  60                  


Leu Pro Arg Lys His Ser Lys Pro Glu Leu Cys Ala Asn Pro Glu Glu 
65                  70                  75                  80  


Gly Trp Val Gln Asn Leu Met Arg Arg Leu Asp Gln Pro Pro Ala Pro 
                85                  90                  95      


Gly Lys Gln Ser Pro Gly Cys Arg Lys Asn Arg Gly Thr Ser Lys Ser 
            100                 105                 110         


Gly Lys Lys Gly Lys Gly Ser Lys Gly Cys Lys Arg Thr Glu Gln Thr 
        115                 120                 125             


Gln Pro Ser Arg Gly 
    130             


<210>  2
<211>  134
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Ala Gln Ser Leu Ala Leu Ser Leu Leu Ile Leu Val Leu Ala Phe 
1               5                   10                  15      


Gly Ile Pro Arg Thr Gln Gly Ser Asp Gly Gly Ala Gln Asp Cys Cys 
            20                  25                  30          


Leu Lys Tyr Ser Gln Arg Lys Ile Pro Ala Lys Val Val Arg Ser Tyr 
        35                  40                  45              


Arg Lys Gln Glu Pro Ser Leu Gly Cys Ser Ile Pro Ala Ile Leu Phe 
    50                  55                  60                  


Leu Pro Arg Lys Arg Ser Gln Ala Glu Leu Cys Ala Asp Pro Lys Glu 
65                  70                  75                  80  


Leu Trp Val Gln Gln Leu Met Gln His Leu Asp Lys Thr Pro Ser Pro 
                85                  90                  95      


Gln Lys Pro Ala Gln Gly Cys Arg Lys Asp Arg Gly Ala Ser Lys Thr 
            100                 105                 110         


Gly Lys Lys Gly Lys Gly Ser Lys Gly Cys Lys Arg Thr Glu Arg Ser 
        115                 120                 125             


Gln Thr Pro Lys Gly Pro 
    130                 


<210>  3
<211>  303
<212>  PRT
<213>  Mus musculus

<400>  3

Met Trp Pro Leu Ala Ala Ala Leu Leu Leu Gly Ser Cys Cys Cys Gly 
1               5                   10                  15      


Ser Ala Gln Leu Leu Phe Ser Asn Val Asn Ser Ile Glu Phe Thr Ser 
            20                  25                  30          


Cys Asn Glu Thr Val Val Ile Pro Cys Ile Val Arg Asn Val Glu Ala 
        35                  40                  45              


Gln Ser Thr Glu Glu Met Phe Val Lys Trp Lys Leu Asn Lys Ser Tyr 
    50                  55                  60                  


Ile Phe Ile Tyr Asp Gly Asn Lys Asn Ser Thr Thr Thr Asp Gln Asn 
65                  70                  75                  80  


Phe Thr Ser Ala Lys Ile Ser Val Ser Asp Leu Ile Asn Gly Ile Ala 
                85                  90                  95      


Ser Leu Lys Met Asp Lys Arg Asp Ala Met Val Gly Asn Tyr Thr Cys 
            100                 105                 110         


Glu Val Thr Glu Leu Ser Arg Glu Gly Lys Thr Val Ile Glu Leu Lys 
        115                 120                 125             


Asn Arg Thr Val Ser Trp Phe Ser Pro Asn Glu Lys Ile Leu Ile Val 
    130                 135                 140                 


Ile Phe Pro Ile Leu Ala Ile Leu Leu Phe Trp Gly Lys Phe Gly Ile 
145                 150                 155                 160 


Leu Thr Leu Lys Tyr Lys Ser Ser His Thr Asn Lys Arg Ile Ile Leu 
                165                 170                 175     


Leu Leu Val Ala Gly Leu Val Leu Thr Val Ile Val Val Val Gly Ala 
            180                 185                 190         


Ile Leu Leu Ile Pro Gly Glu Lys Pro Val Lys Asn Ala Ser Gly Leu 
        195                 200                 205             


Gly Leu Ile Val Ile Ser Thr Gly Ile Leu Ile Leu Leu Gln Tyr Asn 
    210                 215                 220                 


Val Phe Met Thr Ala Phe Gly Met Thr Ser Phe Thr Ile Ala Ile Leu 
225                 230                 235                 240 


Ile Thr Gln Val Leu Gly Tyr Val Leu Ala Leu Val Gly Leu Cys Leu 
                245                 250                 255     


Cys Ile Met Ala Cys Glu Pro Val His Gly Pro Leu Leu Ile Ser Gly 
            260                 265                 270         


Leu Gly Ile Ile Ala Leu Ala Glu Leu Leu Gly Leu Val Tyr Met Lys 
        275                 280                 285             


Phe Val Ala Ser Asn Gln Arg Thr Ile Gln Pro Pro Arg Asn Arg 
    290                 295                 300             


<210>  4
<211>  323
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Trp Pro Leu Val Ala Ala Leu Leu Leu Gly Ser Ala Cys Cys Gly 
1               5                   10                  15      


Ser Ala Gln Leu Leu Phe Asn Lys Thr Lys Ser Val Glu Phe Thr Phe 
            20                  25                  30          


Cys Asn Asp Thr Val Val Ile Pro Cys Phe Val Thr Asn Met Glu Ala 
        35                  40                  45              


Gln Asn Thr Thr Glu Val Tyr Val Lys Trp Lys Phe Lys Gly Arg Asp 
    50                  55                  60                  


Ile Tyr Thr Phe Asp Gly Ala Leu Asn Lys Ser Thr Val Pro Thr Asp 
65                  70                  75                  80  


Phe Ser Ser Ala Lys Ile Glu Val Ser Gln Leu Leu Lys Gly Asp Ala 
                85                  90                  95      


Ser Leu Lys Met Asp Lys Ser Asp Ala Val Ser His Thr Gly Asn Tyr 
            100                 105                 110         


Thr Cys Glu Val Thr Glu Leu Thr Arg Glu Gly Glu Thr Ile Ile Glu 
        115                 120                 125             


Leu Lys Tyr Arg Val Val Ser Trp Phe Ser Pro Asn Glu Asn Ile Leu 
    130                 135                 140                 


Ile Val Ile Phe Pro Ile Phe Ala Ile Leu Leu Phe Trp Gly Gln Phe 
145                 150                 155                 160 


Gly Ile Lys Thr Leu Lys Tyr Arg Ser Gly Gly Met Asp Glu Lys Thr 
                165                 170                 175     


Ile Ala Leu Leu Val Ala Gly Leu Val Ile Thr Val Ile Val Ile Val 
            180                 185                 190         


Gly Ala Ile Leu Phe Val Pro Gly Glu Tyr Ser Leu Lys Asn Ala Thr 
        195                 200                 205             


Gly Leu Gly Leu Ile Val Thr Ser Thr Gly Ile Leu Ile Leu Leu His 
    210                 215                 220                 


Tyr Tyr Val Phe Ser Thr Ala Ile Gly Leu Thr Ser Phe Val Ile Ala 
225                 230                 235                 240 


Ile Leu Val Ile Gln Val Ile Ala Tyr Ile Leu Ala Val Val Gly Leu 
                245                 250                 255     


Ser Leu Cys Ile Ala Ala Cys Ile Pro Met His Gly Pro Leu Leu Ile 
            260                 265                 270         


Ser Gly Leu Ser Ile Leu Ala Leu Ala Gln Leu Leu Gly Leu Val Tyr 
        275                 280                 285             


Met Lys Phe Val Ala Ser Asn Gln Lys Thr Ile Gln Pro Pro Arg Lys 
    290                 295                 300                 


Ala Val Glu Glu Pro Leu Asn Ala Phe Lys Glu Ser Lys Gly Met Met 
305                 310                 315                 320 


Asn Asp Glu 
            


<210>  5
<211>  278
<212>  PRT
<213>  Mus musculus

<400>  5

Met Gly Ser Leu Val Phe Arg Arg Pro Phe Cys His Leu Ser Thr Tyr 
1               5                   10                  15      


Ser Leu Ile Trp Gly Met Ala Ala Val Ala Leu Ser Thr Ala Gln Val 
            20                  25                  30          


Glu Val Val Thr Gln Asp Glu Arg Lys Ala Leu His Thr Thr Ala Ser 
        35                  40                  45              


Leu Arg Cys Ser Leu Lys Thr Ser Gln Glu Pro Leu Ile Val Thr Trp 
    50                  55                  60                  


Gln Lys Lys Lys Ala Val Ser Pro Glu Asn Met Val Thr Tyr Ser Lys 
65                  70                  75                  80  


Thr His Gly Val Val Ile Gln Pro Ala Tyr Lys Asp Arg Ile Asn Val 
                85                  90                  95      


Thr Glu Leu Gly Leu Trp Asn Ser Ser Ile Thr Phe Trp Asn Thr Thr 
            100                 105                 110         


Leu Glu Asp Glu Gly Cys Tyr Met Cys Leu Phe Asn Thr Phe Gly Ser 
        115                 120                 125             


Gln Lys Val Ser Gly Thr Ala Cys Leu Thr Leu Tyr Val Gln Pro Ile 
    130                 135                 140                 


Val His Leu His Tyr Asn Tyr Phe Glu Asp His Leu Asn Ile Thr Cys 
145                 150                 155                 160 


Ser Ala Thr Ala Arg Pro Ala Pro Ala Ile Ser Trp Lys Gly Thr Gly 
                165                 170                 175     


Thr Gly Ile Glu Asn Ser Thr Glu Ser His Phe His Ser Asn Gly Thr 
            180                 185                 190         


Thr Ser Val Thr Ser Ile Leu Arg Val Lys Asp Pro Lys Thr Gln Val 
        195                 200                 205             


Gly Lys Glu Val Ile Cys Gln Val Leu Tyr Leu Gly Asn Val Ile Asp 
    210                 215                 220                 


Tyr Lys Gln Ser Leu Asp Lys Gly Phe Trp Phe Ser Val Pro Leu Leu 
225                 230                 235                 240 


Leu Ser Ile Val Ser Leu Val Ile Leu Leu Val Leu Ile Ser Ile Leu 
                245                 250                 255     


Leu Tyr Trp Lys Arg His Arg Asn Gln Glu Arg Gly Glu Ser Ser Gln 
            260                 265                 270         


Gly Met Gln Arg Met Lys 
        275             


<210>  6
<211>  278
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Glu Arg Leu Val Ile Arg Met Pro Phe Ser His Leu Ser Thr Tyr 
1               5                   10                  15      


Ser Leu Val Trp Val Met Ala Ala Val Val Leu Cys Thr Ala Gln Val 
            20                  25                  30          


Gln Val Val Thr Gln Asp Glu Arg Glu Gln Leu Tyr Thr Pro Ala Ser 
        35                  40                  45              


Leu Lys Cys Ser Leu Gln Asn Ala Gln Glu Ala Leu Ile Val Thr Trp 
    50                  55                  60                  


Gln Lys Lys Lys Ala Val Ser Pro Glu Asn Met Val Thr Phe Ser Glu 
65                  70                  75                  80  


Asn His Gly Val Val Ile Gln Pro Ala Tyr Lys Asp Lys Ile Asn Ile 
                85                  90                  95      


Thr Gln Leu Gly Leu Gln Asn Ser Thr Ile Thr Phe Trp Asn Ile Thr 
            100                 105                 110         


Leu Glu Asp Glu Gly Cys Tyr Met Cys Leu Phe Asn Thr Phe Gly Phe 
        115                 120                 125             


Gly Lys Ile Ser Gly Thr Ala Cys Leu Thr Val Tyr Val Gln Pro Ile 
    130                 135                 140                 


Val Ser Leu His Tyr Lys Phe Ser Glu Asp His Leu Asn Ile Thr Cys 
145                 150                 155                 160 


Ser Ala Thr Ala Arg Pro Ala Pro Met Val Phe Trp Lys Val Pro Arg 
                165                 170                 175     


Ser Gly Ile Glu Asn Ser Thr Val Thr Leu Ser His Pro Asn Gly Thr 
            180                 185                 190         


Thr Ser Val Thr Ser Ile Leu His Ile Lys Asp Pro Lys Asn Gln Val 
        195                 200                 205             


Gly Lys Glu Val Ile Cys Gln Val Leu His Leu Gly Thr Val Thr Asp 
    210                 215                 220                 


Phe Lys Gln Thr Val Asn Lys Gly Tyr Trp Phe Ser Val Pro Leu Leu 
225                 230                 235                 240 


Leu Ser Ile Val Ser Leu Val Ile Leu Leu Val Leu Ile Ser Ile Leu 
                245                 250                 255     


Leu Tyr Trp Lys Arg His Arg Asn Gln Asp Arg Gly Glu Leu Ser Gln 
            260                 265                 270         


Gly Val Gln Lys Met Thr 
        275             


<210>  7
<211>  374
<212>  PRT
<213>  Mus musculus

<400>  7

Met Asn Thr Leu Ser Glu Gly Asn Gly Thr Phe Ala Ile His Leu Leu 
1               5                   10                  15      


Lys Met Leu Cys Gln Ser Asn Pro Ser Lys Asn Val Cys Tyr Ser Pro 
            20                  25                  30          


Ala Ser Ile Ser Ser Ala Leu Ala Met Val Leu Leu Gly Ala Lys Gly 
        35                  40                  45              


Gln Thr Ala Val Gln Ile Ser Gln Ala Leu Gly Leu Asn Lys Glu Glu 
    50                  55                  60                  


Gly Ile His Gln Gly Phe Gln Leu Leu Leu Arg Lys Leu Asn Lys Pro 
65                  70                  75                  80  


Asp Arg Lys Tyr Ser Leu Arg Val Ala Asn Arg Leu Phe Ala Asp Lys 
                85                  90                  95      


Thr Cys Glu Val Leu Gln Thr Phe Lys Glu Ser Ser Leu His Phe Tyr 
            100                 105                 110         


Asp Ser Glu Met Glu Gln Leu Ser Phe Ala Glu Glu Ala Glu Val Ser 
        115                 120                 125             


Arg Gln His Ile Asn Thr Trp Val Ser Lys Gln Thr Glu Gly Lys Ile 
    130                 135                 140                 


Pro Glu Leu Leu Ser Gly Gly Ser Val Asp Ser Glu Thr Arg Leu Val 
145                 150                 155                 160 


Leu Ile Asn Ala Leu Tyr Phe Lys Gly Lys Trp His Gln Pro Phe Asn 
                165                 170                 175     


Lys Glu Tyr Thr Met Asp Met Pro Phe Lys Ile Asn Lys Asp Glu Lys 
            180                 185                 190         


Arg Pro Val Gln Met Met Cys Arg Glu Asp Thr Tyr Asn Leu Ala Tyr 
        195                 200                 205             


Val Lys Glu Val Gln Ala Gln Val Leu Val Met Pro Tyr Glu Gly Met 
    210                 215                 220                 


Glu Leu Ser Leu Val Val Leu Leu Pro Asp Glu Gly Val Asp Leu Ser 
225                 230                 235                 240 


Lys Val Glu Asn Asn Leu Thr Phe Glu Lys Leu Thr Ala Trp Met Glu 
                245                 250                 255     


Ala Asp Phe Met Lys Ser Thr Asp Val Glu Val Phe Leu Pro Lys Phe 
            260                 265                 270         


Lys Leu Gln Glu Asp Tyr Asp Met Glu Ser Leu Phe Gln Arg Leu Gly 
        275                 280                 285             


Val Val Asp Val Phe Gln Glu Asp Lys Ala Asp Leu Ser Gly Met Ser 
    290                 295                 300                 


Pro Glu Arg Asn Leu Cys Val Ser Lys Phe Val His Gln Ser Val Val 
305                 310                 315                 320 


Glu Ile Asn Glu Glu Gly Thr Glu Ala Ala Ala Ala Ser Ala Ile Ile 
                325                 330                 335     


Glu Phe Cys Cys Ala Ser Ser Val Pro Thr Phe Cys Ala Asp His Pro 
            340                 345                 350         


Phe Leu Phe Phe Ile Arg His Asn Lys Ala Asn Ser Ile Leu Phe Cys 
        355                 360                 365             


Gly Arg Phe Ser Ser Pro 
    370                 


<210>  8
<211>  376
<212>  PRT
<213>  Homo sapiens

<400>  8

Met Glu Thr Leu Ser Asn Ala Ser Gly Thr Phe Ala Ile Arg Leu Leu 
1               5                   10                  15      


Lys Ile Leu Cys Gln Asp Asn Pro Ser His Asn Val Phe Cys Ser Pro 
            20                  25                  30          


Val Ser Ile Ser Ser Ala Leu Ala Met Val Leu Leu Gly Ala Lys Gly 
        35                  40                  45              


Asn Thr Ala Thr Gln Met Ala Gln Ala Leu Ser Leu Asn Thr Glu Glu 
    50                  55                  60                  


Asp Ile His Arg Ala Phe Gln Ser Leu Leu Thr Glu Val Asn Lys Ala 
65                  70                  75                  80  


Gly Thr Gln Tyr Leu Leu Arg Thr Ala Asn Arg Leu Phe Gly Glu Lys 
                85                  90                  95      


Thr Cys Gln Phe Leu Ser Thr Phe Lys Glu Ser Cys Leu Gln Phe Tyr 
            100                 105                 110         


His Ala Glu Leu Lys Glu Leu Ser Phe Ile Arg Ala Ala Glu Glu Ser 
        115                 120                 125             


Arg Lys His Ile Asn Thr Trp Val Ser Lys Lys Thr Glu Gly Lys Ile 
    130                 135                 140                 


Glu Glu Leu Leu Pro Gly Ser Ser Ile Asp Ala Glu Thr Arg Leu Val 
145                 150                 155                 160 


Leu Val Asn Ala Ile Tyr Phe Lys Gly Lys Trp Asn Glu Pro Phe Asp 
                165                 170                 175     


Glu Thr Tyr Thr Arg Glu Met Pro Phe Lys Ile Asn Gln Glu Glu Gln 
            180                 185                 190         


Arg Pro Val Gln Met Met Tyr Gln Glu Ala Thr Phe Lys Leu Ala His 
        195                 200                 205             


Val Gly Glu Val Arg Ala Gln Leu Leu Glu Leu Pro Tyr Ala Arg Lys 
    210                 215                 220                 


Glu Leu Ser Leu Leu Val Leu Leu Pro Asp Asp Gly Val Glu Leu Ser 
225                 230                 235                 240 


Thr Val Glu Lys Ser Leu Thr Phe Glu Lys Leu Thr Ala Trp Thr Lys 
                245                 250                 255     


Pro Asp Cys Met Lys Ser Thr Glu Val Glu Val Leu Leu Pro Lys Phe 
            260                 265                 270         


Lys Leu Gln Glu Asp Tyr Asp Met Glu Ser Val Leu Arg His Leu Gly 
        275                 280                 285             


Ile Val Asp Ala Phe Gln Gln Gly Lys Ala Asp Leu Ser Ala Met Ser 
    290                 295                 300                 


Ala Glu Arg Asp Leu Cys Leu Ser Lys Phe Val His Lys Ser Phe Val 
305                 310                 315                 320 


Glu Val Asn Glu Glu Gly Thr Glu Ala Ala Ala Ala Ser Ser Cys Phe 
                325                 330                 335     


Val Val Ala Glu Cys Cys Met Glu Ser Gly Pro Arg Phe Cys Ala Asp 
            340                 345                 350         


His Pro Phe Leu Phe Phe Ile Arg His Asn Arg Ala Asn Ser Ile Leu 
        355                 360                 365             


Phe Cys Gly Arg Phe Ser Ser Pro 
    370                 375     


<210>  9
<211>  279
<212>  PRT
<213>  Mus musculus

<400>  9

Met Gln Gln Pro Met Asn Tyr Pro Cys Pro Gln Ile Phe Trp Val Asp 
1               5                   10                  15      


Ser Ser Ala Thr Ser Ser Trp Thr Pro Pro Gly Ser Val Phe Pro Cys 
            20                  25                  30          


Pro Ser Ser Gly Pro Arg Gly Pro Asp Gln Arg Arg Pro Pro Pro Pro 
        35                  40                  45              


Pro Pro Pro Val Ser Pro Leu Pro Pro Pro Ser Gln Pro Leu Pro Leu 
    50                  55                  60                  


Pro Pro Leu Thr Pro Leu Lys Lys Lys Asp His Asn Thr Asn Leu Trp 
65                  70                  75                  80  


Leu Pro Val Val Phe Phe Met Val Leu Val Ala Leu Val Gly Met Gly 
                85                  90                  95      


Leu Gly Met Tyr Gln Leu Phe His Leu Gln Lys Glu Leu Ala Glu Leu 
            100                 105                 110         


Arg Glu Phe Thr Asn Gln Ser Leu Lys Val Ser Ser Phe Glu Lys Gln 
        115                 120                 125             


Ile Ala Asn Pro Ser Thr Pro Ser Glu Lys Lys Glu Leu Arg Ser Val 
    130                 135                 140                 


Ala His Leu Thr Gly Asn Pro His Ser Arg Ser Ile Pro Leu Glu Trp 
145                 150                 155                 160 


Glu Asp Thr Tyr Gly Thr Ala Leu Ile Ser Gly Val Lys Tyr Lys Lys 
                165                 170                 175     


Gly Ser Leu Val Ile Asn Glu Ala Gly Leu Tyr Phe Val Tyr Ser Lys 
            180                 185                 190         


Val Tyr Phe Arg Gly Gln Ser Cys Asn Asn Gln Pro Leu Asn His Lys 
        195                 200                 205             


Val Tyr Met Arg Asn Ser Lys Tyr Pro Gly Asp Leu Val Leu Met Glu 
    210                 215                 220                 


Glu Lys Arg Leu Asn Tyr Cys Thr Thr Gly Gln Ile Trp Ala His Ser 
225                 230                 235                 240 


Ser Tyr Leu Gly Ala Val Phe Asn Leu Thr Ser Ala Asp His Leu Tyr 
                245                 250                 255     


Val Asn Ile Ser Gln Leu Ser Leu Ile Asn Phe Glu Glu Ser Lys Thr 
            260                 265                 270         


Phe Phe Gly Leu Tyr Lys Leu 
        275                 


<210>  10
<211>  281
<212>  PRT
<213>  Homo sapiens

<400>  10

Met Gln Gln Pro Phe Asn Tyr Pro Tyr Pro Gln Ile Tyr Trp Val Asp 
1               5                   10                  15      


Ser Ser Ala Ser Ser Pro Trp Ala Pro Pro Gly Thr Val Leu Pro Cys 
            20                  25                  30          


Pro Thr Ser Val Pro Arg Arg Pro Gly Gln Arg Arg Pro Pro Pro Pro 
        35                  40                  45              


Pro Pro Pro Pro Pro Leu Pro Pro Pro Pro Pro Pro Pro Pro Leu Pro 
    50                  55                  60                  


Pro Leu Pro Leu Pro Pro Leu Lys Lys Arg Gly Asn His Ser Thr Gly 
65                  70                  75                  80  


Leu Cys Leu Leu Val Met Phe Phe Met Val Leu Val Ala Leu Val Gly 
                85                  90                  95      


Leu Gly Leu Gly Met Phe Gln Leu Phe His Leu Gln Lys Glu Leu Ala 
            100                 105                 110         


Glu Leu Arg Glu Ser Thr Ser Gln Met His Thr Ala Ser Ser Leu Glu 
        115                 120                 125             


Lys Gln Ile Gly His Pro Ser Pro Pro Pro Glu Lys Lys Glu Leu Arg 
    130                 135                 140                 


Lys Val Ala His Leu Thr Gly Lys Ser Asn Ser Arg Ser Met Pro Leu 
145                 150                 155                 160 


Glu Trp Glu Asp Thr Tyr Gly Ile Val Leu Leu Ser Gly Val Lys Tyr 
                165                 170                 175     


Lys Lys Gly Gly Leu Val Ile Asn Glu Thr Gly Leu Tyr Phe Val Tyr 
            180                 185                 190         


Ser Lys Val Tyr Phe Arg Gly Gln Ser Cys Asn Asn Leu Pro Leu Ser 
        195                 200                 205             


His Lys Val Tyr Met Arg Asn Ser Lys Tyr Pro Gln Asp Leu Val Met 
    210                 215                 220                 


Met Glu Gly Lys Met Met Ser Tyr Cys Thr Thr Gly Gln Met Trp Ala 
225                 230                 235                 240 


Arg Ser Ser Tyr Leu Gly Ala Val Phe Asn Leu Thr Ser Ala Asp His 
                245                 250                 255     


Leu Tyr Val Asn Val Ser Glu Leu Ser Leu Val Asn Phe Glu Glu Ser 
            260                 265                 270         


Gln Thr Phe Phe Gly Leu Tyr Lys Leu 
        275                 280     


<210>  11
<211>  290
<212>  PRT
<213>  Mus musculus

<400>  11

Met Arg Ile Phe Ala Gly Ile Ile Phe Thr Ala Cys Cys His Leu Leu 
1               5                   10                  15      


Arg Ala Phe Thr Ile Thr Ala Pro Lys Asp Leu Tyr Val Val Glu Tyr 
            20                  25                  30          


Gly Ser Asn Val Thr Met Glu Cys Arg Phe Pro Val Glu Arg Glu Leu 
        35                  40                  45              


Asp Leu Leu Ala Leu Val Val Tyr Trp Glu Lys Glu Asp Glu Gln Val 
    50                  55                  60                  


Ile Gln Phe Val Ala Gly Glu Glu Asp Leu Lys Pro Gln His Ser Asn 
65                  70                  75                  80  


Phe Arg Gly Arg Ala Ser Leu Pro Lys Asp Gln Leu Leu Lys Gly Asn 
                85                  90                  95      


Ala Ala Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr 
            100                 105                 110         


Cys Cys Ile Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Leu 
        115                 120                 125             


Lys Val Asn Ala Pro Tyr Arg Lys Ile Asn Gln Arg Ile Ser Val Asp 
    130                 135                 140                 


Pro Ala Thr Ser Glu His Glu Leu Ile Cys Gln Ala Glu Gly Tyr Pro 
145                 150                 155                 160 


Glu Ala Glu Val Ile Trp Thr Asn Ser Asp His Gln Pro Val Ser Gly 
                165                 170                 175     


Lys Arg Ser Val Thr Thr Ser Arg Thr Glu Gly Met Leu Leu Asn Val 
            180                 185                 190         


Thr Ser Ser Leu Arg Val Asn Ala Thr Ala Asn Asp Val Phe Tyr Cys 
        195                 200                 205             


Thr Phe Trp Arg Ser Gln Pro Gly Gln Asn His Thr Ala Glu Leu Ile 
    210                 215                 220                 


Ile Pro Glu Leu Pro Ala Thr His Pro Pro Gln Asn Arg Thr His Trp 
225                 230                 235                 240 


Val Leu Leu Gly Ser Ile Leu Leu Phe Leu Ile Val Val Ser Thr Val 
                245                 250                 255     


Leu Leu Phe Leu Arg Lys Gln Val Arg Met Leu Asp Val Glu Lys Cys 
            260                 265                 270         


Gly Val Glu Asp Thr Ser Ser Lys Asn Arg Asn Asp Thr Gln Phe Glu 
        275                 280                 285             


Glu Thr 
    290 


<210>  12
<211>  290
<212>  PRT
<213>  Homo sapiens

<400>  12

Met Arg Ile Phe Ala Val Phe Ile Phe Met Thr Tyr Trp His Leu Leu 
1               5                   10                  15      


Asn Ala Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr 
            20                  25                  30          


Gly Ser Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu 
        35                  40                  45              


Asp Leu Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile 
    50                  55                  60                  


Ile Gln Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser 
65                  70                  75                  80  


Tyr Arg Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn 
                85                  90                  95      


Ala Ala Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr 
            100                 105                 110         


Arg Cys Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val 
        115                 120                 125             


Lys Val Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val 
    130                 135                 140                 


Asp Pro Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr 
145                 150                 155                 160 


Pro Lys Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser 
                165                 170                 175     


Gly Lys Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn 
            180                 185                 190         


Val Thr Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr 
        195                 200                 205             


Cys Thr Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu 
    210                 215                 220                 


Val Ile Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr His 
225                 230                 235                 240 


Leu Val Ile Leu Gly Ala Ile Leu Leu Cys Leu Gly Val Ala Leu Thr 
                245                 250                 255     


Phe Ile Phe Arg Leu Arg Lys Gly Arg Met Met Asp Val Lys Lys Cys 
            260                 265                 270         


Gly Ile Gln Asp Thr Asn Ser Lys Lys Gln Ser Asp Thr His Leu Glu 
        275                 280                 285             


Glu Thr 
    290 


<210>  13
<211>  463
<212>  PRT
<213>  Mus musculus

<400>  13

Met Gln Val Ser Arg Val Leu Ala Ala Leu Cys Gly Met Leu Leu Cys 
1               5                   10                  15      


Ala Ser Gly Leu Phe Ala Ala Ser Gly Asp Phe Cys Asp Ser Ser Leu 
            20                  25                  30          


Cys Leu Asn Gly Gly Thr Cys Leu Thr Gly Gln Asp Asn Asp Ile Tyr 
        35                  40                  45              


Cys Leu Cys Pro Glu Gly Phe Thr Gly Leu Val Cys Asn Glu Thr Glu 
    50                  55                  60                  


Arg Gly Pro Cys Ser Pro Asn Pro Cys Tyr Asn Asp Ala Lys Cys Leu 
65                  70                  75                  80  


Val Thr Leu Asp Thr Gln Arg Gly Asp Ile Phe Thr Glu Tyr Ile Cys 
                85                  90                  95      


Gln Cys Pro Val Gly Tyr Ser Gly Ile His Cys Glu Thr Glu Thr Asn 
            100                 105                 110         


Tyr Tyr Asn Leu Asp Gly Glu Tyr Met Phe Thr Thr Ala Val Pro Asn 
        115                 120                 125             


Thr Ala Val Pro Thr Pro Ala Pro Thr Pro Asp Leu Ser Asn Asn Leu 
    130                 135                 140                 


Ala Ser Arg Cys Ser Thr Gln Leu Gly Met Glu Gly Gly Ala Ile Ala 
145                 150                 155                 160 


Asp Ser Gln Ile Ser Ala Ser Ser Val Tyr Met Gly Phe Met Gly Leu 
                165                 170                 175     


Gln Arg Trp Gly Pro Glu Leu Ala Arg Leu Tyr Arg Thr Gly Ile Val 
            180                 185                 190         


Asn Ala Trp Thr Ala Ser Asn Tyr Asp Ser Lys Pro Trp Ile Gln Val 
        195                 200                 205             


Asn Leu Leu Arg Lys Met Arg Val Ser Gly Val Met Thr Gln Gly Ala 
    210                 215                 220                 


Ser Arg Ala Gly Arg Ala Glu Tyr Leu Lys Thr Phe Lys Val Ala Tyr 
225                 230                 235                 240 


Ser Leu Asp Gly Arg Lys Phe Glu Phe Ile Gln Asp Glu Ser Gly Gly 
                245                 250                 255     


Asp Lys Glu Phe Leu Gly Asn Leu Asp Asn Asn Ser Leu Lys Val Asn 
            260                 265                 270         


Met Phe Asn Pro Thr Leu Glu Ala Gln Tyr Ile Lys Leu Tyr Pro Val 
        275                 280                 285             


Ser Cys His Arg Gly Cys Thr Leu Arg Phe Glu Leu Leu Gly Cys Glu 
    290                 295                 300                 


Leu His Gly Cys Ser Glu Pro Leu Gly Leu Lys Asn Asn Thr Ile Pro 
305                 310                 315                 320 


Asp Ser Gln Met Ser Ala Ser Ser Ser Tyr Lys Thr Trp Asn Leu Arg 
                325                 330                 335     


Ala Phe Gly Trp Tyr Pro His Leu Gly Arg Leu Asp Asn Gln Gly Lys 
            340                 345                 350         


Ile Asn Ala Trp Thr Ala Gln Ser Asn Ser Ala Lys Glu Trp Leu Gln 
        355                 360                 365             


Val Asp Leu Gly Thr Gln Arg Gln Val Thr Gly Ile Ile Thr Gln Gly 
    370                 375                 380                 


Ala Arg Asp Phe Gly His Ile Gln Tyr Val Ala Ser Tyr Lys Val Ala 
385                 390                 395                 400 


His Ser Asp Asp Gly Val Gln Trp Thr Val Tyr Glu Glu Gln Gly Ser 
                405                 410                 415     


Ser Lys Val Phe Gln Gly Asn Leu Asp Asn Asn Ser His Lys Lys Asn 
            420                 425                 430         


Ile Phe Glu Lys Pro Phe Met Ala Arg Tyr Val Arg Val Leu Pro Val 
        435                 440                 445             


Ser Trp His Asn Arg Ile Thr Leu Arg Leu Glu Leu Leu Gly Cys 
    450                 455                 460             


<210>  14
<211>  387
<212>  PRT
<213>  Homo sapiens

<400>  14

Met Pro Arg Pro Arg Leu Leu Ala Ala Leu Cys Gly Ala Leu Leu Cys 
1               5                   10                  15      


Ala Pro Ser Leu Leu Val Ala Leu Asp Ile Cys Ser Lys Asn Pro Cys 
            20                  25                  30          


His Asn Gly Gly Leu Cys Glu Glu Ile Ser Gln Glu Val Arg Gly Asp 
        35                  40                  45              


Val Phe Pro Ser Tyr Thr Cys Thr Cys Leu Lys Gly Tyr Ala Gly Asn 
    50                  55                  60                  


His Cys Glu Thr Lys Cys Val Glu Pro Leu Gly Met Glu Asn Gly Asn 
65                  70                  75                  80  


Ile Ala Asn Ser Gln Ile Ala Ala Ser Ser Val Arg Val Thr Phe Leu 
                85                  90                  95      


Gly Leu Gln His Trp Val Pro Glu Leu Ala Arg Leu Asn Arg Ala Gly 
            100                 105                 110         


Met Val Asn Ala Trp Thr Pro Ser Ser Asn Asp Asp Asn Pro Trp Ile 
        115                 120                 125             


Gln Val Asn Leu Leu Arg Arg Met Trp Val Thr Gly Val Val Thr Gln 
    130                 135                 140                 


Gly Ala Ser Arg Leu Ala Ser His Glu Tyr Leu Lys Ala Phe Lys Val 
145                 150                 155                 160 


Ala Tyr Ser Leu Asn Gly His Glu Phe Asp Phe Ile His Asp Val Asn 
                165                 170                 175     


Lys Lys His Lys Glu Phe Val Gly Asn Trp Asn Lys Asn Ala Val His 
            180                 185                 190         


Val Asn Leu Phe Glu Thr Pro Val Glu Ala Gln Tyr Val Arg Leu Tyr 
        195                 200                 205             


Pro Thr Ser Cys His Thr Ala Cys Thr Leu Arg Phe Glu Leu Leu Gly 
    210                 215                 220                 


Cys Glu Leu Asn Gly Cys Ala Asn Pro Leu Gly Leu Lys Asn Asn Ser 
225                 230                 235                 240 


Ile Pro Asp Lys Gln Ile Thr Ala Ser Ser Ser Tyr Lys Thr Trp Gly 
                245                 250                 255     


Leu His Leu Phe Ser Trp Asn Pro Ser Tyr Ala Arg Leu Asp Lys Gln 
            260                 265                 270         


Gly Asn Phe Asn Ala Trp Val Ala Gly Ser Tyr Gly Asn Asp Gln Trp 
        275                 280                 285             


Leu Gln Val Asp Leu Gly Ser Ser Lys Glu Val Thr Gly Ile Ile Thr 
    290                 295                 300                 


Gln Gly Ala Arg Asn Phe Gly Ser Val Gln Phe Val Ala Ser Tyr Lys 
305                 310                 315                 320 


Val Ala Tyr Ser Asn Asp Ser Ala Asn Trp Thr Glu Tyr Gln Asp Pro 
                325                 330                 335     


Arg Thr Gly Ser Ser Lys Ile Phe Pro Gly Asn Trp Asp Asn His Ser 
            340                 345                 350         


His Lys Lys Asn Leu Phe Glu Thr Pro Ile Leu Ala Arg Tyr Val Arg 
        355                 360                 365             


Ile Leu Pro Val Ala Trp His Asn Arg Ile Ala Leu Arg Leu Glu Leu 
    370                 375                 380                 


Leu Gly Cys 
385         


<210>  15
<211>  249
<212>  PRT
<213>  Mus musculus

<400>  15

Ser Ile Glu Glu Ile Pro Arg Met Glu Pro Arg Ala Pro Trp Met Glu 
1               5                   10                  15      


Lys Glu Arg Pro Glu Tyr Trp Lys Glu Leu Lys Leu Lys Val Lys Asn 
            20                  25                  30          


Ile Ala Gln Ser Ala Arg Ala Asn Leu Arg Thr Leu Leu Arg Tyr Tyr 
        35                  40                  45              


Asn Gln Ser Glu Gly Gly Ser His Ile Leu Gln Trp Met Val Ser Cys 
    50                  55                  60                  


Glu Val Gly Pro Asp Met Arg Leu Leu Gly Ala His Tyr Gln Ala Ala 
65                  70                  75                  80  


Tyr Asp Gly Ser Asp Tyr Ile Thr Leu Asn Glu Asp Leu Ser Ser Trp 
                85                  90                  95      


Thr Ala Val Asp Met Val Ser Gln Ile Thr Lys Ser Arg Leu Glu Ser 
            100                 105                 110         


Ala Gly Thr Ala Glu Tyr Phe Arg Ala Tyr Val Glu Gly Glu Cys Leu 
        115                 120                 125             


Glu Leu Leu His Arg Phe Leu Arg Asn Gly Lys Glu Ile Leu Gln Arg 
    130                 135                 140                 


Ala Asp Pro Pro Lys Ala His Val Ala His His Pro Arg Pro Lys Gly 
145                 150                 155                 160 


Asp Val Thr Leu Arg Cys Trp Ala Leu Gly Phe Tyr Pro Ala Asp Ile 
                165                 170                 175     


Thr Leu Thr Trp Gln Lys Asp Glu Glu Asp Leu Thr Gln Asp Met Glu 
            180                 185                 190         


Leu Val Glu Thr Arg Pro Ser Gly Asp Gly Thr Phe Gln Lys Trp Ala 
        195                 200                 205             


Ala Val Val Val Pro Ser Gly Glu Glu Gln Arg Tyr Thr Cys Tyr Val 
    210                 215                 220                 


His His Glu Gly Leu Thr Glu Pro Leu Ala Leu Lys Trp Gly Arg Ser 
225                 230                 235                 240 


Ser Gln Ser Ser Val Val Ile Met Val 
                245                 


<210>  16
<211>  338
<212>  PRT
<213>  Homo sapiens

<400>  16

Met Val Val Met Ala Pro Arg Thr Leu Phe Leu Leu Leu Ser Gly Ala 
1               5                   10                  15      


Leu Thr Leu Thr Glu Thr Trp Ala Gly Ser His Ser Met Arg Tyr Phe 
            20                  25                  30          


Ser Ala Ala Val Ser Arg Pro Gly Arg Gly Glu Pro Arg Phe Ile Ala 
        35                  40                  45              


Met Gly Tyr Val Asp Asp Thr Gln Phe Val Arg Phe Asp Ser Asp Ser 
    50                  55                  60                  


Ala Cys Pro Arg Met Glu Pro Arg Ala Pro Trp Val Glu Gln Glu Gly 
65                  70                  75                  80  


Pro Glu Tyr Trp Glu Glu Glu Thr Arg Asn Thr Lys Ala His Ala Gln 
                85                  90                  95      


Thr Asp Arg Met Asn Leu Gln Thr Leu Arg Gly Tyr Tyr Asn Gln Ser 
            100                 105                 110         


Glu Ala Ser Ser His Thr Leu Gln Trp Met Ile Gly Cys Asp Leu Gly 
        115                 120                 125             


Ser Asp Gly Arg Leu Leu Arg Gly Tyr Glu Gln Tyr Ala Tyr Asp Gly 
    130                 135                 140                 


Lys Asp Tyr Leu Ala Leu Asn Glu Asp Leu Arg Ser Trp Thr Ala Ala 
145                 150                 155                 160 


Asp Thr Ala Ala Gln Ile Ser Lys Arg Lys Cys Glu Ala Ala Asn Val 
                165                 170                 175     


Ala Glu Gln Arg Arg Ala Tyr Leu Glu Gly Thr Cys Val Glu Trp Leu 
            180                 185                 190         


His Arg Tyr Leu Glu Asn Gly Lys Glu Met Leu Gln Arg Ala Asp Pro 
        195                 200                 205             


Pro Lys Thr His Val Thr His His Pro Val Phe Asp Tyr Glu Ala Thr 
    210                 215                 220                 


Leu Arg Cys Trp Ala Leu Gly Phe Tyr Pro Ala Glu Ile Ile Leu Thr 
225                 230                 235                 240 


Trp Gln Arg Asp Gly Glu Asp Gln Thr Gln Asp Val Glu Leu Val Glu 
                245                 250                 255     


Thr Arg Pro Ala Gly Asp Gly Thr Phe Gln Lys Trp Ala Ala Val Val 
            260                 265                 270         


Val Pro Ser Gly Glu Glu Gln Arg Tyr Thr Cys His Val Gln His Glu 
        275                 280                 285             


Gly Leu Pro Glu Pro Leu Met Leu Arg Trp Lys Gln Ser Ser Leu Pro 
    290                 295                 300                 


Thr Ile Pro Ile Met Gly Ile Val Ala Gly Leu Val Val Leu Ala Ala 
305                 310                 315                 320 


Val Val Thr Gly Ala Ala Val Ala Ala Val Leu Trp Arg Lys Lys Ser 
                325                 330                 335     


Ser Asp 
        


<210>  17
<211>  439
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  17

Met Gly Pro Gln Ala Ala Ala Gly Arg Met Ile Leu Leu Val Val Leu 
1               5                   10                  15      


Met Leu Ser Ala Lys Val Gly Ser Gly Ala Leu Thr Ser Thr Glu Asp 
            20                  25                  30          


Pro Glu Pro Pro Ser Val Pro Val Pro Thr Asn Val Leu Ile Lys Ser 
        35                  40                  45              


Tyr Asn Leu Asn Pro Val Val Cys Trp Glu Tyr Gln Asn Met Ser Gln 
    50                  55                  60                  


Thr Pro Ile Phe Thr Val Gln Val Lys Val Tyr Ser Gly Ser Trp Thr 
65                  70                  75                  80  


Asp Ser Cys Thr Asn Ile Ser Asp His Cys Cys Asn Ile Tyr Gly Gln 
                85                  90                  95      


Ile Met Tyr Pro Asp Val Ser Ala Trp Ala Arg Val Lys Ala Lys Val 
            100                 105                 110         


Gly Gln Lys Glu Ser Asp Tyr Ala Arg Ser Lys Glu Phe Leu Met Cys 
        115                 120                 125             


Leu Lys Gly Lys Val Gly Pro Pro Gly Leu Glu Ile Arg Arg Lys Lys 
    130                 135                 140                 


Glu Glu Gln Leu Ser Val Leu Val Phe His Pro Glu Val Val Val Asn 
145                 150                 155                 160 


Gly Glu Ser Gln Gly Thr Met Phe Gly Asp Gly Ser Thr Cys Tyr Thr 
                165                 170                 175     


Phe Asp Tyr Thr Val Tyr Val Glu His Asn Arg Ser Gly Glu Ile Leu 
            180                 185                 190         


His Thr Lys His Thr Val Glu Lys Glu Glu Cys Asn Glu Thr Leu Cys 
        195                 200                 205             


Glu Leu Asn Ile Ser Val Ser Thr Leu Asp Ser Arg Tyr Cys Ile Ser 
    210                 215                 220                 


Val Asp Gly Ile Ser Ser Phe Trp Gln Val Arg Thr Glu Lys Ser Lys 
225                 230                 235                 240 


Asp Val Cys Ile Pro Pro Phe His Asp Asp Arg Lys Asp Ser Ile Trp 
                245                 250                 255     


Ile Leu Val Val Ala Pro Leu Thr Val Phe Thr Val Val Ile Leu Val 
            260                 265                 270         


Phe Ala Tyr Trp Tyr Thr Lys Lys Asn Ser Phe Lys Arg Lys Ser Ile 
        275                 280                 285             


Met Leu Pro Lys Ser Leu Leu Ser Val Val Lys Ser Ala Thr Leu Glu 
    290                 295                 300                 


Thr Lys Pro Glu Ser Lys Tyr Ser Leu Val Thr Pro His Gln Pro Ala 
305                 310                 315                 320 


Val Leu Glu Ser Glu Thr Val Ile Cys Glu Glu Pro Leu Ser Thr Val 
                325                 330                 335     


Thr Ala Pro Asp Ser Pro Glu Ala Ala Glu Gln Glu Glu Leu Ser Lys 
            340                 345                 350         


Glu Thr Lys Ala Leu Glu Ala Gly Gly Ser Thr Ser Ala Met Thr Pro 
        355                 360                 365             


Asp Ser Pro Pro Thr Pro Thr Gln Arg Arg Ser Phe Ser Leu Leu Ser 
    370                 375                 380                 


Ser Asn Gln Ser Gly Pro Cys Ser Leu Thr Ala Tyr His Ser Arg Asn 
385                 390                 395                 400 


Gly Ser Asp Ser Gly Leu Val Gly Ser Gly Ser Ser Ile Ser Asp Leu 
                405                 410                 415     


Glu Ser Leu Pro Asn Asn Asn Ser Glu Thr Lys Met Ala Glu His Asp 
            420                 425                 430         


Pro Pro Pro Val Arg Lys Ala 
        435                 


