                         SEQUENCE LISTING



<110>  Antibody BioPharm, Inc.

 

<120>  GUIDED COMBINATIONAL THERAPEUTIC ANTIBODY



<130>  1023-701WO



<140>  TBA

<141>  2018-06-07



<150>  US 62/516,583

<151>  2017-06-07



<160>  69    



<170>  PatentIn version 3.5



<210>  1

<211>  360

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic polynucleotide



<400>  1

gaggtgcagc tggtggagtc tggaggaggc ttggtccagc ctggggggtc cctgagactc       60



tcctgtgcag cctctgggtt caacatcaaa gacacctaca tccactgggt ccgccaggct      120



ccagggaagg agcgggagtg ggtcgcccgg atttatccca caaacggtta cacacggtac      180



gcagactccg tgaagggccg attcaccatc tccagagaca atgccaagga cactgtgtat      240



cttcaaatga acagcctgag agccgaggac acggccgtgt attactgttc ccggtgggga      300



ggggacgggt tctatgctat ggactactgg ggccaaggaa cactggtcac cgtctcgagc      360





<210>  2

<211>  120

<212>  PRT

<213>  Artificial Sequence



<220>

<223>  Synthetic polypeptide



<400>  2



Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 

1               5                   10                  15      





Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile Lys Asp Thr 

            20                  25                  30          





Tyr Ile His Trp Val Arg Gln Ala Pro Gly Lys Glu Arg Glu Trp Val 

        35                  40                  45              





Ala Arg Ile Tyr Pro Thr Asn Gly Tyr Thr Arg Tyr Ala Asp Ser Val 

    50                  55                  60                  





Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asp Thr Val Tyr 

65                  70                  75                  80  





Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 

                85                  90                  95      





Ser Arg Trp Gly Gly Asp Gly Phe Tyr Ala Met Asp Tyr Trp Gly Gln 

            100                 105                 110         





Gly Thr Leu Val Thr Val Ser Ser 

        115                 120 





<210>  3

<211>  369

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic polynucleotide



<400>  3

caggtgcagc tggtgcagtc tgggggagga ttggtgcagg ctgggggctc tctgagactc       60



tcctgtgcag cctctggacg caccttcagt agttatgcca tggcctggtt ccgccaggct      120



ccagggaagg agcgtgagtt tgtagcagct attagctgga gtggtgcaaa catatacgtt      180



gcagactccg tgaagggccg attcaccatc tccagagaca acgccaagga cacggtgtat      240



ctgcaaatga acagcctgaa acctgaggac acggccgttt attactgtgc agtaaagctc      300



ggtttcgcac ctgtagaaga aaggcagtat gactactggg gccaggggac ccaggtcacc      360



gtctcgagc                                                              369





<210>  4

<211>  123

<212>  PRT

<213>  Artificial Sequence



<220>

<223>  Synthetic polypeptide



<400>  4



Gln Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 

1               5                   10                  15      





Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Ser Ser Tyr 

            20                  25                  30          





Ala Met Ala Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 

        35                  40                  45              





Ala Ala Ile Ser Trp Ser Gly Ala Asn Ile Tyr Val Ala Asp Ser Val 

    50                  55                  60                  





Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asp Thr Val Tyr 

65                  70                  75                  80  





Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 

                85                  90                  95      





Ala Val Lys Leu Gly Phe Ala Pro Val Glu Glu Arg Gln Tyr Asp Tyr 

            100                 105                 110         





Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 

        115                 120             





<210>  5

<211>  351

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic polynucleotide



<400>  5

gaagaggaac tccaggtgat ccagcccgac aagtccgtga gcgtggctgc tggagagagc       60



gccatcctgc actgtaccgt gacctccctg atccctgtgg gacccatcca gtggttcaga      120



ggagctggac ctgcaagaga actgatctac aaccagaagg agggacactt ccctagagtg      180



accacagtga gcgagtccac caagcgggag aacatggact tctccatcag catctccaac      240



atcacccctg ctgacgcagg cacctactat tgcgtgaagt tcaggaaggg cagccctgac      300



accgagttca agtccggcgc tggaaccgag ctgagcgtga gagccaagcc c               351





<210>  6

<211>  117

<212>  PRT

<213>  Artificial Sequence



<220>

<223>  Synthetic polypeptide



<400>  6



Glu Glu Glu Leu Gln Val Ile Gln Pro Asp Lys Ser Val Ser Val Ala 

1               5                   10                  15      





Ala Gly Glu Ser Ala Ile Leu His Cys Thr Val Thr Ser Leu Ile Pro 

            20                  25                  30          





Val Gly Pro Ile Gln Trp Phe Arg Gly Ala Gly Pro Ala Arg Glu Leu 

        35                  40                  45              





Ile Tyr Asn Gln Lys Glu Gly His Phe Pro Arg Val Thr Thr Val Ser 

    50                  55                  60                  





Glu Ser Thr Lys Arg Glu Asn Met Asp Phe Ser Ile Ser Ile Ser Asn 

65                  70                  75                  80  





Ile Thr Pro Ala Asp Ala Gly Thr Tyr Tyr Cys Val Lys Phe Arg Lys 

                85                  90                  95      





Gly Ser Pro Asp Thr Glu Phe Lys Ser Gly Ala Gly Thr Glu Leu Ser 

            100                 105                 110         





Val Arg Ala Lys Pro 

        115         





<210>  7

<211>  354

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic polynucleotide



<400>  7

gaagaggaac tccaggtgat ccagcccgac aagtccgtga gcgtggctgc tggagagagc       60



gccatcctgc actgtaccgt gacctccctg atccctgtgg gacccatcca gtggttcaga      120



ggagctggac ctgcaagaga actgatctac aaccagaagg agggacactt ccctagagtg      180



accacagtga gcgagtccac caagcggaat aacatggact tctccatcag aatcggcaac      240



atcacccctg ctgacgcagg cacctactat tgcgtgaagt tcaggaaggg cagccctgac      300



gatgtcgagt tcaagtccgg cgctggaacc gagctgagcg tgagagccaa gccc            354





<210>  8

<211>  118

<212>  PRT

<213>  Artificial Sequence



<220>

<223>  Synthetic polypeptide



<400>  8



Glu Glu Glu Leu Gln Val Ile Gln Pro Asp Lys Ser Val Ser Val Ala 

1               5                   10                  15      





Ala Gly Glu Ser Ala Ile Leu His Cys Thr Val Thr Ser Leu Ile Pro 

            20                  25                  30          





Val Gly Pro Ile Gln Trp Phe Arg Gly Ala Gly Pro Ala Arg Glu Leu 

        35                  40                  45              





Ile Tyr Asn Gln Lys Glu Gly His Phe Pro Arg Val Thr Thr Val Ser 

    50                  55                  60                  





Glu Ser Thr Lys Arg Asn Asn Met Asp Phe Ser Ile Arg Ile Gly Asn 

65                  70                  75                  80  





Ile Thr Pro Ala Asp Ala Gly Thr Tyr Tyr Cys Val Lys Phe Arg Lys 

                85                  90                  95      





Gly Ser Pro Asp Asp Val Glu Phe Lys Ser Gly Ala Gly Thr Glu Leu 

            100                 105                 110         





Ser Val Arg Ala Lys Pro 

        115             





<210>  9

<211>  378

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic polynucleotide



<400>  9

gactccccag acaggccctg gaaccccccc accttctccc cagccctgct cgtggtgacc       60



gaaggggaca acgccacctt cacctgtagc ttctccaaca catcggagag cttcgtgcta      120



aactggtatc gcatgagccc cagcaaccag acggacaagc tggccgcctt ccccgaggac      180



cgcagccagc ccggccagga ctgccgcttc cgtgtcacac aactgcccaa cgggcgtgac      240



ttccacatga gcgtggtcag agcccggcgc aatgacagcg gcacctacct ctgtggagct      300



atctcccggg cccccaaggc gcagatcaaa gagagcctgc gggcagagct gagggtgaca      360



gagagaaggg cagaagtc                                                    378





<210>  10

<211>  126

<212>  PRT

<213>  Artificial Sequence



<220>

<223>  Synthetic polypeptide



<400>  10



Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu 

1               5                   10                  15      





Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser 

            20                  25                  30          





Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr Arg Met Ser Pro Ser 

        35                  40                  45              





Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro 

    50                  55                  60                  





Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp 

65                  70                  75                  80  





Phe His Met Ser Val Val Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr 

                85                  90                  95      





Leu Cys Gly Ala Ile Ser Arg Ala Pro Lys Ala Gln Ile Lys Glu Ser 

            100                 105                 110         





Leu Arg Ala Glu Leu Arg Val Thr Glu Arg Arg Ala Glu Val 

        115                 120                 125     





<210>  11

<211>  378

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic polynucleotide



<400>  11

gactccccag acagaccttg gaacccacct accttctccc cagcactgct cgtcgtgacc       60



gaaggagaca acgcaacctt cacctgtagc ttctccaaca catcggagag cttcgtgcta      120



aactggtatc gcatgagccc tagcaaccag actgacaagc tggcagcctt ccctgaggac      180



cgcagccagc caggacagga ctgccgcttc cgtgtcacac aactgcccaa cggacgtgac      240



ttccacatga gcgtggtcag agcaagacgc aatgacagcg gcacctacct ctgtggagct      300



atctccctgg ctcccaaggc acagatcaaa gagagcctga gggcagagct gagggtgaca      360



gagagaaggg cagaagtc                                                    378





<210>  12

<211>  126

<212>  PRT

<213>  Artificial Sequence



<220>

<223>  Synthetic polypeptide



<400>  12



Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu 

1               5                   10                  15      





Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser 

            20                  25                  30          





Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr Arg Met Ser Pro Ser 

        35                  40                  45              





Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro 

    50                  55                  60                  





Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp 

65                  70                  75                  80  





Phe His Met Ser Val Val Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr 

                85                  90                  95      





Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Ala Gln Ile Lys Glu Ser 

            100                 105                 110         





Leu Arg Ala Glu Leu Arg Val Thr Glu Arg Arg Ala Glu Val 

        115                 120                 125     





<210>  13

<211>  15

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic polynucleotide



<400>  13

tcgagcgcgt cgacc                                                        15





<210>  14

<211>  12

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic polynucleotide



<400>  14

tcgagccgta cg                                                           12





<210>  15

<211>  9

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic polynucleotide



<400>  15

gcgtcgacc                                                                9





<210>  16

<211>  24

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic polynucleotide



<400>  16

gcgtcgaccg gcggtggtgg gtcg                                              24





<210>  17

<211>  39

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic polynucleotide



<400>  17

gcgtcgaccg gcggaggtgg gtccggggga ggcggaagc                              39





<210>  18

<211>  54

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic polynucleotide



<400>  18

gcgtcgaccg gcggaggtgg gtccggggga ggcggaagcg gagggggcgg atct             54





<210>  19

<211>  63

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic polynucleotide



<400>  19

gcgtcgaccg gcggaggtgg gtccggggga ggcggaagcg gagggggcgg atctggaggt       60



agc                                                                     63





<210>  20

<211>  24

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic polynucleotide



<400>  20

tcgagcgcgt cgaccccact cgga                                              24





<210>  21

<211>  33

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic polynucleotide



<400>  21

tcgagcgcgt cgaccccact cggagacacc aca                                    33





<210>  22

<211>  45

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic polynucleotide



<400>  22

tcgagcgcgt cgaccccact cggagacacc acacacacca gccct                       45





<210>  23

<211>  54

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic polynucleotide



<400>  23

tcgagcgcgt cgaccccact cggagacacc acacacacca gccctagatc tcca             54





<210>  24

<211>  60

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic polynucleotide



<400>  24

tcgagcgcgt cgaccagccc tagatctcca gagcccaaga gctccgacac acccccacct       60





<210>  25

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic polynucleotide



<400>  25

tcgagcgata agacccacac t                                                 21





<210>  26

<211>  30

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic polynucleotide



<400>  26

tcgagcgata agacccacac tgcgtcgacc                                        30





<210>  27

<211>  30

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic polynucleotide



<400>  27

tcgagcgaca agacacgtac ggcgtcgacc                                        30





<210>  28

<211>  1350

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic polynucleotide



<400>  28

gaagaggaac tccaggtgat ccagcccgac aagtccgtga gcgtggctgc tggagagagc       60



gccatcctgc actgtaccgt gacctccctg atccctgtgg gacccatcca gtggttcaga      120



ggagctggac ctgcaagaga actgatctac aaccagaagg agggacactt ccctagagtg      180



accacagtga gcgagtccac caagcggaat aacatggact tctccatcag aatcggcaac      240



atcacccctg ctgacgcagg cacctactat tgcgtgaagt tcaggaaggg cagccctgac      300



gatgtcgagt tcaagtccgg cgctggaacc gagctgagcg tgagagccaa gccctcgagc      360



gcgtcgacca agggcccatc ggtcttcccg ctagcaccct cctccaagag cacctctggg      420



ggcacagcgg ccctgggctg cctggtcaag gactacttcc ccgaacctgt gacggtgtcg      480



tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca      540



ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacccagacc      600



tacatctgca acgtgaatca caagcccagc aacaccaagg tggacaagaa agttgagccc      660



aaatcttgtg acaaaactca cacatgccca ccgtgcccag cacctgaagc tgctggggga      720



ccgtcagtct tcctcttccc cccaaaaccc aaggacaccc tcatgatctc ccggacccct      780



gaggtcacat gcgtggtggt ggacgtgagc cacgaagacc ctgaggtcaa gttcaactgg      840



tacgtggacg gcgtggaggt gcataatgcc aagacaaagc cgcgggagga gcagtacaac      900



agcacgtacc gggtggtcag cgtcctcacc gtcctgcacc aggactggct gaatggcaag      960



gagtacaagt gcaaggtctc caacaaagcc ctcggagccc ccatcgagaa aaccatctcc     1020



aaagccaaag ggcagccccg agaaccacag gtgtacaccc tgcccccatc cagggatgag     1080



ctgaccaaga accaggtcag cctgacctgc ctggtcaaag gcttctatcc cagcgacatc     1140



gccgtggagt gggagagcaa tgggcagccg gagaacaact acaagaccac gcctcccgtg     1200



ctggactccg acggctcctt cttcctctac agcaagctca ccgtggacaa gagcaggtgg     1260



cagcagggga acgtcttctc atgctccgtg atgcatgagg ctctgcacaa ccactacacg     1320



cagaagagcc tctccctgtc tcccgggaaa                                      1350





<210>  29

<211>  450

<212>  PRT

<213>  Artificial Sequence



<220>

<223>  Synthetic polypeptide



<400>  29



Glu Glu Glu Leu Gln Val Ile Gln Pro Asp Lys Ser Val Ser Val Ala 

1               5                   10                  15      





Ala Gly Glu Ser Ala Ile Leu His Cys Thr Val Thr Ser Leu Ile Pro 

            20                  25                  30          





Val Gly Pro Ile Gln Trp Phe Arg Gly Ala Gly Pro Ala Arg Glu Leu 

        35                  40                  45              





Ile Tyr Asn Gln Lys Glu Gly His Phe Pro Arg Val Thr Thr Val Ser 

    50                  55                  60                  





Glu Ser Thr Lys Arg Asn Asn Met Asp Phe Ser Ile Arg Ile Gly Asn 

65                  70                  75                  80  





Ile Thr Pro Ala Asp Ala Gly Thr Tyr Tyr Cys Val Lys Phe Arg Lys 

                85                  90                  95      





Gly Ser Pro Asp Asp Val Glu Phe Lys Ser Gly Ala Gly Thr Glu Leu 

            100                 105                 110         





Ser Val Arg Ala Lys Pro Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 

        115                 120                 125             





Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 

    130                 135                 140                 





Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 

145                 150                 155                 160 





Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 

                165                 170                 175     





Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 

            180                 185                 190         





Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 

        195                 200                 205             





Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 

    210                 215                 220                 





Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly 

225                 230                 235                 240 





Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 

                245                 250                 255     





Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 

            260                 265                 270         





Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 

        275                 280                 285             





Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 

    290                 295                 300                 





Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 

305                 310                 315                 320 





Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Gly Ala Pro Ile Glu 

                325                 330                 335     





Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 

            340                 345                 350         





Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 

        355                 360                 365             





Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 

    370                 375                 380                 





Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 

385                 390                 395                 400 





Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 

                405                 410                 415     





Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 

            420                 425                 430         





Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 

        435                 440                 445             





Gly Lys 

    450 





<210>  30

<211>  705

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic polynucleotide



<400>  30

gactccccag acaggccctg gaaccccccc accttctccc cagccctgct cgtggtgacc       60



gaaggggaca acgccacctt cacctgtagc ttctccaaca catcggagag cttcgtgcta      120



aactggtatc gcatgagccc cagcaaccag acggacaagc tggccgcctt ccccgaggac      180



cgcagccagc ccggccagga ctgccgcttc cgtgtcacac aactgcccaa cgggcgtgac      240



ttccacatga gcgtggtcag agcccggcgc aatgacagcg gcacctacct ctgtggagct      300



atctcccggg cccccaaggc gcagatcaaa gagagcctgc gggcagagct gagggtgaca      360



gagagaaggg cagaagtctc gagccgtacg gtggctgcac catctgtctt catcttcccg      420



ccatctgatg agcagttgaa atctggaact gcctctgttg tgtgcctgct gaataacttc      480



tatcccagag aggccaaagt acagtggaag gtggataacg ccctccaatc gggtaactcc      540



caggagagtg tcacagagca ggacagcaag gacagcacct acagcctcag cagcaccctg      600



acgctgagca aagcagacta cgagaaacac aaagtctacg cctgcgaagt cacccatcag      660



ggcctgagct cgcccgtcac aaagagcttc aacaggggag agtgt                      705





<210>  31

<211>  235

<212>  PRT

<213>  Artificial Sequence



<220>

<223>  Synthetic polypeptide



<400>  31



Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu 

1               5                   10                  15      





Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser 

            20                  25                  30          





Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr Arg Met Ser Pro Ser 

        35                  40                  45              





Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro 

    50                  55                  60                  





Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp 

65                  70                  75                  80  





Phe His Met Ser Val Val Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr 

                85                  90                  95      





Leu Cys Gly Ala Ile Ser Arg Ala Pro Lys Ala Gln Ile Lys Glu Ser 

            100                 105                 110         





Leu Arg Ala Glu Leu Arg Val Thr Glu Arg Arg Ala Glu Val Ser Ser 

        115                 120                 125             





Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 

    130                 135                 140                 





Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 

145                 150                 155                 160 





Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 

                165                 170                 175     





Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 

            180                 185                 190         





Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 

        195                 200                 205             





Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 

    210                 215                 220                 





Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 

225                 230                 235 





<210>  32

<211>  1347

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic polynucleotide



<400>  32

gaagaggaac tccaggtgat ccagcccgac aagtccgtga gcgtggctgc tggagagagc       60



gccatcctgc actgtaccgt gacctccctg atccctgtgg gacccatcca gtggttcaga      120



ggagctggac ctgcaagaga actgatctac aaccagaagg agggacactt ccctagagtg      180



accacagtga gcgagtccac caagcgggag aacatggact tctccatcag catctccaac      240



atcacccctg ctgacgcagg cacctactat tgcgtgaagt tcaggaaggg cagccctgac      300



accgagttca agtccggcgc tggaaccgag ctgagcgtga gagccaagcc ctcgagcgcg      360



tcgaccaagg gcccatcggt cttcccgcta gcaccctcct ccaagagcac ctctgggggc      420



acagcggccc tgggctgcct ggtcaaggac tacttccccg aacctgtgac ggtgtcgtgg      480



aactcaggcg ccctgaccag cggcgtgcac accttcccgg ctgtcctaca gtcctcagga      540



ctctactccc tcagcagcgt ggtgaccgtg ccctccagca gcttgggcac ccagacctac      600



atctgcaacg tgaatcacaa gcccagcaac accaaggtgg acaagaaagt tgagcccaaa      660



tcttgtgaca aaactcacac atgcccaccg tgcccagcac ctgaagctgc tgggggaccg      720



tcagtcttcc tcttcccccc aaaacccaag gacaccctca tgatctcccg gacccctgag      780



gtcacatgcg tggtggtgga cgtgagccac gaagaccctg aggtcaagtt caactggtac      840



gtggacggcg tggaggtgca taatgccaag acaaagccgc gggaggagca gtacaacagc      900



acgtaccggg tggtcagcgt cctcaccgtc ctgcaccagg actggctgaa tggcaaggag      960



tacaagtgca aggtctccaa caaagccctc ggagccccca tcgagaaaac catctccaaa     1020



gccaaagggc agccccgaga accacaggtg tacaccctgc ccccatccag ggatgagctg     1080



accaagaacc aggtcagcct gacctgcctg gtcaaaggct tctatcccag cgacatcgcc     1140



gtggagtggg agagcaatgg gcagccggag aacaactaca agaccacgcc tcccgtgctg     1200



gactccgacg gctccttctt cctctacagc aagctcaccg tggacaagag caggtggcag     1260



caggggaacg tcttctcatg ctccgtgatg catgaggctc tgcacaacca ctacacgcag     1320



aagagcctct ccctgtctcc cgggaaa                                         1347





<210>  33

<211>  449

<212>  PRT

<213>  Artificial Sequence



<220>

<223>  Synthetic polypeptide



<400>  33



Glu Glu Glu Leu Gln Val Ile Gln Pro Asp Lys Ser Val Ser Val Ala 

1               5                   10                  15      





Ala Gly Glu Ser Ala Ile Leu His Cys Thr Val Thr Ser Leu Ile Pro 

            20                  25                  30          





Val Gly Pro Ile Gln Trp Phe Arg Gly Ala Gly Pro Ala Arg Glu Leu 

        35                  40                  45              





Ile Tyr Asn Gln Lys Glu Gly His Phe Pro Arg Val Thr Thr Val Ser 

    50                  55                  60                  





Glu Ser Thr Lys Arg Glu Asn Met Asp Phe Ser Ile Ser Ile Ser Asn 

65                  70                  75                  80  





Ile Thr Pro Ala Asp Ala Gly Thr Tyr Tyr Cys Val Lys Phe Arg Lys 

                85                  90                  95      





Gly Ser Pro Asp Thr Glu Phe Lys Ser Gly Ala Gly Thr Glu Leu Ser 

            100                 105                 110         





Val Arg Ala Lys Pro Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 

        115                 120                 125             





Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu 

    130                 135                 140                 





Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 

145                 150                 155                 160 





Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 

                165                 170                 175     





Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 

            180                 185                 190         





Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro 

        195                 200                 205             





Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys 

    210                 215                 220                 





Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro 

225                 230                 235                 240 





Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 

                245                 250                 255     





Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 

            260                 265                 270         





Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 

        275                 280                 285             





Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 

    290                 295                 300                 





Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 

305                 310                 315                 320 





Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Gly Ala Pro Ile Glu Lys 

                325                 330                 335     





Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 

            340                 345                 350         





Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr 

        355                 360                 365             





Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 

    370                 375                 380                 





Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 

385                 390                 395                 400 





Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 

                405                 410                 415     





Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 

            420                 425                 430         





Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 

        435                 440                 445             





Lys 

    





<210>  34

<211>  705

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic polynucleotide



<400>  34

gactccccag acagaccttg gaacccacct accttctccc cagcactgct cgtcgtgacc       60



gaaggagaca acgcaacctt cacctgtagc ttctccaaca catcggagag cttcgtgcta      120



aactggtatc gcatgagccc tagcaaccag actgacaagc tggcagcctt ccctgaggac      180



cgcagccagc caggacagga ctgccgcttc cgtgtcacac aactgcccaa cggacgtgac      240



ttccacatga gcgtggtcag agcaagacgc aatgacagcg gcacctacct ctgtggagct      300



atctccctgg ctcccaaggc acagatcaaa gagagcctga gggcagagct gagggtgaca      360



gagagaaggg cagaagtctc gagccgtacg gtggctgcac catctgtctt catcttcccg      420



ccatctgatg agcagttgaa atctggaact gcctctgttg tgtgcctgct gaataacttc      480



tatcccagag aggccaaagt acagtggaag gtggataacg ccctccaatc gggtaactcc      540



caggagagtg tcacagagca ggacagcaag gacagcacct acagcctcag cagcaccctg      600



acgctgagca aagcagacta cgagaaacac aaagtctacg cctgcgaagt cacccatcag      660



ggcctgagct cgcccgtcac aaagagcttc aacaggggag agtgt                      705





<210>  35

<211>  235

<212>  PRT

<213>  Artificial Sequence



<220>

<223>  Synthetic polypeptide



<400>  35



Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu 

1               5                   10                  15      





Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser 

            20                  25                  30          





Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr Arg Met Ser Pro Ser 

        35                  40                  45              





Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro 

    50                  55                  60                  





Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp 

65                  70                  75                  80  





Phe His Met Ser Val Val Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr 

                85                  90                  95      





Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Ala Gln Ile Lys Glu Ser 

            100                 105                 110         





Leu Arg Ala Glu Leu Arg Val Thr Glu Arg Arg Ala Glu Val Ser Ser 

        115                 120                 125             





Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 

    130                 135                 140                 





Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 

145                 150                 155                 160 





Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 

                165                 170                 175     





Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 

            180                 185                 190         





Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 

        195                 200                 205             





Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 

    210                 215                 220                 





Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 

225                 230                 235 





<210>  36

<211>  1350

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic polynucleotide



<400>  36

gaggtgcagc tggtggagtc tggaggaggc ttggtccagc ctggggggtc cctgagactc       60



tcctgtgcag cctctgggtt caacatcaaa gacacctaca tccactgggt ccgccaggct      120



ccagggaagg agcgggagtg ggtcgcccgg atttatccca caaacggtta cacacggtac      180



gcagactccg tgaagggccg attcaccatc tccagagaca atgccaagga cactgtgtat      240



cttcaaatga acagcctgag agccgaggac acggccgtgt attactgttc ccggtgggga      300



ggggacgggt tctatgctat ggactactgg ggccaaggaa cactggtcac cgtctcgagc      360



gcgtcgacca agggcccatc ggtcttcccg ctagcaccct cctccaagag cacctctggg      420



ggcacagcgg ccctgggctg cctggtcaag gactacttcc ccgaacctgt gacggtgtcg      480



tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca      540



ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacccagacc      600



tacatctgca acgtgaatca caagcccagc aacaccaagg tggacaagaa agttgagccc      660



aaatcttgtg acaaaactca cacatgccca ccgtgcccag cacctgaact cctgggggga      720



ccgtcagtct tcctcttccc cccaaaaccc aaggacaccc tcatgatctc ccggacccct      780



gaggtcacat gcgtggtggt ggacgtgagc cacgaagacc ctgaggtcaa gttcaactgg      840



tacgtggacg gcgtggaggt gcataatgcc aagacaaagc cgcgggagga gcagtacaac      900



agcacgtacc gggtggtcag cgtcctcacc gtcctgcacc aggactggct gaatggcaag      960



gagtacaagt gcaaggtctc caacaaagcc ctcccagccc ccatcgagaa aaccatctcc     1020



aaagccaaag ggcagccccg agaaccacag gtgtacaccc tgcccccatc cagggatgag     1080



ctgaccaaga accaggtcag cctgacctgc ctggtcaaag gcttctatcc cagcgacatc     1140



gccgtggagt gggagagcaa tgggcagccg gagaacaact acaagaccac gcctcccgtg     1200



ctggactccg acggctcctt cttcctctac agcaagctca ccgtggacaa gagcaggtgg     1260



cagcagggga acgtcttctc atgctccgtg atgcatgagg ctctgcacaa ccactacacg     1320



cagaagagcc tctccctgtc tcccgggaaa                                      1350





<210>  37

<211>  450

<212>  PRT

<213>  Artificial Sequence



<220>

<223>  Synthetic polypeptide



<400>  37



Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 

1               5                   10                  15      





Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile Lys Asp Thr 

            20                  25                  30          





Tyr Ile His Trp Val Arg Gln Ala Pro Gly Lys Glu Arg Glu Trp Val 

        35                  40                  45              





Ala Arg Ile Tyr Pro Thr Asn Gly Tyr Thr Arg Tyr Ala Asp Ser Val 

    50                  55                  60                  





Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asp Thr Val Tyr 

65                  70                  75                  80  





Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 

                85                  90                  95      





Ser Arg Trp Gly Gly Asp Gly Phe Tyr Ala Met Asp Tyr Trp Gly Gln 

            100                 105                 110         





Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 

        115                 120                 125             





Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 

    130                 135                 140                 





Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 

145                 150                 155                 160 





Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 

                165                 170                 175     





Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 

            180                 185                 190         





Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 

        195                 200                 205             





Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 

    210                 215                 220                 





Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 

225                 230                 235                 240 





Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 

                245                 250                 255     





Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 

            260                 265                 270         





Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 

        275                 280                 285             





Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 

    290                 295                 300                 





Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 

305                 310                 315                 320 





Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 

                325                 330                 335     





Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 

            340                 345                 350         





Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 

        355                 360                 365             





Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 

    370                 375                 380                 





Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 

385                 390                 395                 400 





Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 

                405                 410                 415     





Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 

            420                 425                 430         





Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 

        435                 440                 445             





Gly Lys 

    450 





<210>  38

<211>  684

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic polynucleotide



<400>  38

gaagaggaac tccaggtgat ccagcccgac aagtccgtga gcgtggctgc tggagagagc       60



gccatcctgc actgtaccgt gacctccctg atccctgtgg gacccatcca gtggttcaga      120



ggagctggac ctgcaagaga actgatctac aaccagaagg agggacactt ccctagagtg      180



accacagtga gcgagtccac caagcggaat aacatggact tctccatcag aatcggcaac      240



atcacccctg ctgacgcagg cacctactat tgcgtgaagt tcaggaaggg cagccctgac      300



gatgtcgagt tcaagtccgg cgctggaacc gagctgagcg tgagagccaa gccctcgagc      360



cgtacggtgg ctgcaccatc tgtcttcatc ttcccgccat ctgatgagca gttgaaatct      420



ggaactgcct ctgttgtgtg cctgctgaat aacttctatc ccagagaggc caaagtacag      480



tggaaggtgg ataacgccct ccaatcgggt aactcccagg agagtgtcac agagcaggac      540



agcaaggaca gcacctacag cctcagcagc accctgacgc tgagcaaagc agactacgag      600



aaacacaaag tctacgcctg cgaagtcacc catcagggcc tgagctcgcc cgtcacaaag      660



agcttcaaca ggggagagtg ttag                                             684





<210>  39

<211>  227

<212>  PRT

<213>  Artificial Sequence



<220>

<223>  Synthetic polypeptide



<400>  39



Glu Glu Glu Leu Gln Val Ile Gln Pro Asp Lys Ser Val Ser Val Ala 

1               5                   10                  15      





Ala Gly Glu Ser Ala Ile Leu His Cys Thr Val Thr Ser Leu Ile Pro 

            20                  25                  30          





Val Gly Pro Ile Gln Trp Phe Arg Gly Ala Gly Pro Ala Arg Glu Leu 

        35                  40                  45              





Ile Tyr Asn Gln Lys Glu Gly His Phe Pro Arg Val Thr Thr Val Ser 

    50                  55                  60                  





Glu Ser Thr Lys Arg Asn Asn Met Asp Phe Ser Ile Arg Ile Gly Asn 

65                  70                  75                  80  





Ile Thr Pro Ala Asp Ala Gly Thr Tyr Tyr Cys Val Lys Phe Arg Lys 

                85                  90                  95      





Gly Ser Pro Asp Asp Val Glu Phe Lys Ser Gly Ala Gly Thr Glu Leu 

            100                 105                 110         





Ser Val Arg Ala Lys Pro Ser Ser Arg Thr Val Ala Ala Pro Ser Val 

        115                 120                 125             





Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser 

    130                 135                 140                 





Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln 

145                 150                 155                 160 





Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val 

                165                 170                 175     





Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu 

            180                 185                 190         





Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu 

        195                 200                 205             





Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg 

    210                 215                 220                 





Gly Glu Cys 

225         





<210>  40

<211>  1359

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic polynucleotide



<400>  40

caggtgcagc tggtgcagtc tgggggagga ttggtgcagg ctgggggctc tctgagactc       60



tcctgtgcag cctctggacg caccttcagt agttatgcca tggcctggtt ccgccaggct      120



ccagggaagg agcgtgagtt tgtagcagct attagctgga gtggtgcaaa catatacgtt      180



gcagactccg tgaagggccg attcaccatc tccagagaca acgccaagga cacggtgtat      240



ctgcaaatga acagcctgaa acctgaggac acggccgttt attactgtgc agtaaagctc      300



ggtttcgcac ctgtagaaga aaggcagtat gactactggg gccaggggac ccaggtcacc      360



gtctcgagcg cgtcgaccaa gggcccatcg gtcttcccgc tagcaccctc ctccaagagc      420



acctctgggg gcacagcggc cctgggctgc ctggtcaagg actacttccc cgaacctgtg      480



acggtgtcgt ggaactcagg cgccctgacc agcggcgtgc acaccttccc ggctgtccta      540



cagtcctcag gactctactc cctcagcagc gtggtgaccg tgccctccag cagcttgggc      600



acccagacct acatctgcaa cgtgaatcac aagcccagca acaccaaggt ggacaagaaa      660



gttgagccca aatcttgtga caaaactcac acatgcccac cgtgcccagc acctgaactc      720



ctggggggac cgtcagtctt cctcttcccc ccaaaaccca aggacaccct catgatctcc      780



cggacccctg aggtcacatg cgtggtggtg gacgtgagcc acgaagaccc tgaggtcaag      840



ttcaactggt acgtggacgg cgtggaggtg cataatgcca agacaaagcc gcgggaggag      900



cagtacaaca gcacgtaccg ggtggtcagc gtcctcaccg tcctgcacca ggactggctg      960



aatggcaagg agtacaagtg caaggtctcc aacaaagccc tcccagcccc catcgagaaa     1020



accatctcca aagccaaagg gcagccccga gaaccacagg tgtacaccct gcccccatcc     1080



agggatgagc tgaccaagaa ccaggtcagc ctgacctgcc tggtcaaagg cttctatccc     1140



agcgacatcg ccgtggagtg ggagagcaat gggcagccgg agaacaacta caagaccacg     1200



cctcccgtgc tggactccga cggctccttc ttcctctaca gcaagctcac cgtggacaag     1260



agcaggtggc agcaggggaa cgtcttctca tgctccgtga tgcatgaggc tctgcacaac     1320



cactacacgc agaagagcct ctccctgtct cccgggaaa                            1359





<210>  41

<211>  453

<212>  PRT

<213>  Artificial Sequence



<220>

<223>  Synthetic polypeptide



<400>  41



Gln Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 

1               5                   10                  15      





Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Ser Ser Tyr 

            20                  25                  30          





Ala Met Ala Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 

        35                  40                  45              





Ala Ala Ile Ser Trp Ser Gly Ala Asn Ile Tyr Val Ala Asp Ser Val 

    50                  55                  60                  





Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asp Thr Val Tyr 

65                  70                  75                  80  





Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 

                85                  90                  95      





Ala Val Lys Leu Gly Phe Ala Pro Val Glu Glu Arg Gln Tyr Asp Tyr 

            100                 105                 110         





Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Ala Ser Thr Lys Gly 

        115                 120                 125             





Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly 

    130                 135                 140                 





Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val 

145                 150                 155                 160 





Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe 

                165                 170                 175     





Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val 

            180                 185                 190         





Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val 

        195                 200                 205             





Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys 

    210                 215                 220                 





Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu 

225                 230                 235                 240 





Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 

                245                 250                 255     





Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 

            260                 265                 270         





Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 

        275                 280                 285             





Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 

    290                 295                 300                 





Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 

305                 310                 315                 320 





Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 

                325                 330                 335     





Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 

            340                 345                 350         





Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln 

        355                 360                 365             





Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 

    370                 375                 380                 





Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 

385                 390                 395                 400 





Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 

                405                 410                 415     





Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 

            420                 425                 430         





Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 

        435                 440                 445             





Leu Ser Pro Gly Lys 

    450             





<210>  42

<211>  678

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic polynucleotide



<400>  42

gaagaggaac tccaggtgat ccagcccgac aagtccgtga gcgtggctgc tggagagagc       60



gccatcctgc actgtaccgt gacctccctg atccctgtgg gacccatcca gtggttcaga      120



ggagctggac ctgcaagaga actgatctac aaccagaagg agggacactt ccctagagtg      180



accacagtga gcgagtccac caagcgggag aacatggact tctccatcag catctccaac      240



atcacccctg ctgacgcagg cacctactat tgcgtgaagt tcaggaaggg cagccctgac      300



accgagttca agtccggcgc tggaaccgag ctgagcgtga gagccaagcc ctcgagccgt      360



acggtggctg caccatctgt cttcatcttc ccgccatctg atgagcagtt gaaatctgga      420



actgcctctg ttgtgtgcct gctgaataac ttctatccca gagaggccaa agtacagtgg      480



aaggtggata acgccctcca atcgggtaac tcccaggaga gtgtcacaga gcaggacagc      540



aaggacagca cctacagcct cagcagcacc ctgacgctga gcaaagcaga ctacgagaaa      600



cacaaagtct acgcctgcga agtcacccat cagggcctga gctcgcccgt cacaaagagc      660



ttcaacaggg gagagtgt                                                    678





<210>  43

<211>  226

<212>  PRT

<213>  Artificial Sequence



<220>

<223>  Synthetic polypeptide



<400>  43



Glu Glu Glu Leu Gln Val Ile Gln Pro Asp Lys Ser Val Ser Val Ala 

1               5                   10                  15      





Ala Gly Glu Ser Ala Ile Leu His Cys Thr Val Thr Ser Leu Ile Pro 

            20                  25                  30          





Val Gly Pro Ile Gln Trp Phe Arg Gly Ala Gly Pro Ala Arg Glu Leu 

        35                  40                  45              





Ile Tyr Asn Gln Lys Glu Gly His Phe Pro Arg Val Thr Thr Val Ser 

    50                  55                  60                  





Glu Ser Thr Lys Arg Glu Asn Met Asp Phe Ser Ile Ser Ile Ser Asn 

65                  70                  75                  80  





Ile Thr Pro Ala Asp Ala Gly Thr Tyr Tyr Cys Val Lys Phe Arg Lys 

                85                  90                  95      





Gly Ser Pro Asp Thr Glu Phe Lys Ser Gly Ala Gly Thr Glu Leu Ser 

            100                 105                 110         





Val Arg Ala Lys Pro Ser Ser Arg Thr Val Ala Ala Pro Ser Val Phe 

        115                 120                 125             





Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val 

    130                 135                 140                 





Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp 

145                 150                 155                 160 





Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr 

                165                 170                 175     





Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr 

            180                 185                 190         





Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val 

        195                 200                 205             





Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly 

    210                 215                 220                 





Glu Cys 

225     





<210>  44

<211>  1098

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic polynucleotide



<400>  44

gactccccag acaggccctg gaaccccccc accttctccc cagccctgct cgtggtgacc       60



gaaggggaca acgccacctt cacctgtagc ttctccaaca catcggagag cttcgtgcta      120



aactggtatc gcatgagccc cagcaaccag acggacaagc tggccgcctt ccccgaggac      180



cgcagccagc ccggccagga ctgccgcttc cgtgtcacac aactgcccaa cgggcgtgac      240



ttccacatga gcgtggtcag agcccggcgc aatgacagcg gcacctacct ctgtggagct      300



atctcccggg cccccaaggc gcagatcaaa gagagcctgc gggcagagct gagggtgaca      360



gagagaaggg cagaagtctc gagccgtacg gtggctgcac catctgtctt catcttcccg      420



ccatctgatg agcagttgaa atctggaact gcctctgttg tgtgcctgct gaataacttc      480



tatcccagag aggccaaagt acagtggaag gtggataacg ccctccaatc gggtaactcc      540



caggagagtg tcacagagca ggacagcaag gacagcacct acagcctcag cagcaccctg      600



acgctgagca aagcagacta cgagaaacac aaagtctacg cctgcgaagt cacccatcag      660



ggcctgagct cgcccgtcac aaagagcttc aacaggggag agtgtaccgt cctaggtcag      720



cccaaggcgg ccgctgaggt gcagctggtg gagtctgggg gaggcttggt acagcctggg      780



gggtccctga gactctcctg tgcagcctct ggattcacct ttgacgacta tggcatgagc      840



tgggtccgcc aggctccagg gaagtggctg gagtgggtct cagatattag ctggaatggt      900



ggtagcacat actacgcaga ctccgtgaag ggccggttca ccatctccag agacaatgcc      960



gagaacacgc tgtatctgca aatgaacagc ctgaaacctg acgacacggc cgtgtattac     1020



tgtgcgaaaa tgggtgaagg gggatggggt gcaaatgact actggggcca ggggacccag     1080



gtcaccgtgt cctcataa                                                   1098





<210>  45

<211>  365

<212>  PRT

<213>  Artificial Sequence



<220>

<223>  Synthetic polypeptide



<400>  45



Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu 

1               5                   10                  15      





Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser 

            20                  25                  30          





Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr Arg Met Ser Pro Ser 

        35                  40                  45              





Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro 

    50                  55                  60                  





Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp 

65                  70                  75                  80  





Phe His Met Ser Val Val Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr 

                85                  90                  95      





Leu Cys Gly Ala Ile Ser Arg Ala Pro Lys Ala Gln Ile Lys Glu Ser 

            100                 105                 110         





Leu Arg Ala Glu Leu Arg Val Thr Glu Arg Arg Ala Glu Val Ser Ser 

        115                 120                 125             





Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 

    130                 135                 140                 





Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 

145                 150                 155                 160 





Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 

                165                 170                 175     





Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 

            180                 185                 190         





Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 

        195                 200                 205             





Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 

    210                 215                 220                 





Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys Thr Val Leu Gly Gln 

225                 230                 235                 240 





Pro Lys Ala Ala Ala Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu 

                245                 250                 255     





Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 

            260                 265                 270         





Thr Phe Asp Asp Tyr Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys 

        275                 280                 285             





Trp Leu Glu Trp Val Ser Asp Ile Ser Trp Asn Gly Gly Ser Thr Tyr 

    290                 295                 300                 





Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala 

305                 310                 315                 320 





Glu Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Lys Pro Asp Asp Thr 

                325                 330                 335     





Ala Val Tyr Tyr Cys Ala Lys Met Gly Glu Gly Gly Trp Gly Ala Asn 

            340                 345                 350         





Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 

        355                 360                 365 





<210>  46

<211>  1095

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic polynucleotide



<400>  46

gactccccag acaggccctg gaaccccccc accttctccc cagccctgct cgtggtgacc       60



gaaggggaca acgccacctt cacctgtagc ttctccaaca catcggagag cttcgtgcta      120



aactggtatc gcatgagccc cagcaaccag acggacaagc tggccgcctt ccccgaggac      180



cgcagccagc ccggccagga ctgccgcttc cgtgtcacac aactgcccaa cgggcgtgac      240



ttccacatga gcgtggtcag agcccggcgc aatgacagcg gcacctacct ctgtggagct      300



atctcccggg cccccaaggc gcagatcaaa gagagcctgc gggcagagct gagggtgaca      360



gagagaaggg cagaagtctc gagccgtacg gtggctgcac catctgtctt catcttcccg      420



ccatctgatg agcagttgaa atctggaact gcctctgttg tgtgcctgct gaataacttc      480



tatcccagag aggccaaagt acagtggaag gtggataacg ccctccaatc gggtaactcc      540



caggagagtg tcacagagca ggacagcaag gacagcacct acagcctcag cagcaccctg      600



acgctgagca aagcagacta cgagaaacac aaagtctacg cctgcgaagt cacccatcag      660



ggcctgagct cgcccgtcac aaagagcttc aacaggggag agtgtaccgt cctaggtcag      720



cccaaggcgg ccgctgaggt gcagctggtg gagtctgggg gaggcttagt gcagcctggg      780



gagtctctga cactctcctg tgtagttgct ggaagcatct tcagcttcgc catgagctgg      840



tatcgccagg ctccaggaaa agagcgcgaa ttggtcgcac gtattggttc ggatgatcgg      900



gtaacctacg cagattccgt gaagggccga tttaccatct ccagagacaa catcaagcgc      960



acggcgggcc tgcagatgaa cagcctgaaa cctgaggaca cggccgtcta ctactgcaat     1020



gcccaaacag atttgaggga ttggactgtg cgagagtact ggggccaggg gacccaggtc     1080



accgtctcct cataa                                                      1095





<210>  47

<211>  364

<212>  PRT

<213>  Artificial Sequence



<220>

<223>  Synthetic polynucleotide



<400>  47



Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu 

1               5                   10                  15      





Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser 

            20                  25                  30          





Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr Arg Met Ser Pro Ser 

        35                  40                  45              





Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro 

    50                  55                  60                  





Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp 

65                  70                  75                  80  





Phe His Met Ser Val Val Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr 

                85                  90                  95      





Leu Cys Gly Ala Ile Ser Arg Ala Pro Lys Ala Gln Ile Lys Glu Ser 

            100                 105                 110         





Leu Arg Ala Glu Leu Arg Val Thr Glu Arg Arg Ala Glu Val Ser Ser 

        115                 120                 125             





Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 

    130                 135                 140                 





Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 

145                 150                 155                 160 





Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 

                165                 170                 175     





Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 

            180                 185                 190         





Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 

        195                 200                 205             





Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 

    210                 215                 220                 





Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys Thr Val Leu Gly Gln 

225                 230                 235                 240 





Pro Lys Ala Ala Ala Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu 

                245                 250                 255     





Val Gln Pro Gly Glu Ser Leu Thr Leu Ser Cys Val Val Ala Gly Ser 

            260                 265                 270         





Ile Phe Ser Phe Ala Met Ser Trp Tyr Arg Gln Ala Pro Gly Lys Glu 

        275                 280                 285             





Arg Glu Leu Val Ala Arg Ile Gly Ser Asp Asp Arg Val Thr Tyr Ala 

    290                 295                 300                 





Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ile Lys Arg 

305                 310                 315                 320 





Thr Ala Gly Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val 

                325                 330                 335     





Tyr Tyr Cys Asn Ala Gln Thr Asp Leu Arg Asp Trp Thr Val Arg Glu 

            340                 345                 350         





Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 

        355                 360                 





<210>  48

<211>  1095

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic polynucleotide



<400>  48

gactccccag acagaccttg gaacccacct accttctccc cagcactgct cgtcgtgacc       60



gaaggagaca acgcaacctt cacctgtagc ttctccaaca catcggagag cttcgtgcta      120



aactggtatc gcatgagccc tagcaaccag actgacaagc tggcagcctt ccctgaggac      180



cgcagccagc caggacagga ctgccgcttc cgtgtcacac aactgcccaa cggacgtgac      240



ttccacatga gcgtggtcag agcaagacgc aatgacagcg gcacctacct ctgtggagct      300



atctccctgg ctcccaaggc acagatcaaa gagagcctga gggcagagct gagggtgaca      360



gagagaaggg cagaagtctc gagccgtacg gtggctgcac catctgtctt catcttcccg      420



ccatctgatg agcagttgaa atctggaact gcctctgttg tgtgcctgct gaataacttc      480



tatcccagag aggccaaagt acagtggaag gtggataacg ccctccaatc gggtaactcc      540



caggagagtg tcacagagca ggacagcaag gacagcacct acagcctcag cagcaccctg      600



acgctgagca aagcagacta cgagaaacac aaagtctacg cctgcgaagt cacccatcag      660



ggcctgagct cgcccgtcac aaagagcttc aacaggggag agtgtaccgt cctaggtcag      720



cccaaggcgg ccgctgaggt gcagctggtg gagtctgggg gaggcttggt acagcctggg      780



gggtccctga gactctcctg tgcagcctct ggattcacct ttgacgacta tggcatgagc      840



tgggtccgcc aggctccagg gaagtggctg gagtgggtct cagatattag ctggaatggt      900



ggtagcacat actacgcaga ctccgtgaag ggccggttca ccatctccag agacaatgcc      960



gagaacacgc tgtatctgca aatgaacagc ctgaaacctg acgacacggc cgtgtattac     1020



tgtgcgaaaa tgggtgaagg gggatggggt gcaaatgact actggggcca ggggacccag     1080



gtcaccgtgt cctca                                                      1095





<210>  49

<211>  365

<212>  PRT

<213>  Artificial Sequence



<220>

<223>  Synthetic polypeptide



<400>  49



Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu 

1               5                   10                  15      





Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser 

            20                  25                  30          





Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr Arg Met Ser Pro Ser 

        35                  40                  45              





Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro 

    50                  55                  60                  





Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp 

65                  70                  75                  80  





Phe His Met Ser Val Val Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr 

                85                  90                  95      





Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Ala Gln Ile Lys Glu Ser 

            100                 105                 110         





Leu Arg Ala Glu Leu Arg Val Thr Glu Arg Arg Ala Glu Val Ser Ser 

        115                 120                 125             





Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 

    130                 135                 140                 





Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 

145                 150                 155                 160 





Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 

                165                 170                 175     





Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 

            180                 185                 190         





Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 

        195                 200                 205             





Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 

    210                 215                 220                 





Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys Thr Val Leu Gly Gln 

225                 230                 235                 240 





Pro Lys Ala Ala Ala Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu 

                245                 250                 255     





Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 

            260                 265                 270         





Thr Phe Asp Asp Tyr Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys 

        275                 280                 285             





Trp Leu Glu Trp Val Ser Asp Ile Ser Trp Asn Gly Gly Ser Thr Tyr 

    290                 295                 300                 





Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala 

305                 310                 315                 320 





Glu Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Lys Pro Asp Asp Thr 

                325                 330                 335     





Ala Val Tyr Tyr Cys Ala Lys Met Gly Glu Gly Gly Trp Gly Ala Asn 

            340                 345                 350         





Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 

        355                 360                 365 





<210>  50

<211>  1092

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic polynucleotide



<400>  50

gactccccag acagaccttg gaacccacct accttctccc cagcactgct cgtcgtgacc       60



gaaggagaca acgcaacctt cacctgtagc ttctccaaca catcggagag cttcgtgcta      120



aactggtatc gcatgagccc tagcaaccag actgacaagc tggcagcctt ccctgaggac      180



cgcagccagc caggacagga ctgccgcttc cgtgtcacac aactgcccaa cggacgtgac      240



ttccacatga gcgtggtcag agcaagacgc aatgacagcg gcacctacct ctgtggagct      300



atctccctgg ctcccaaggc acagatcaaa gagagcctga gggcagagct gagggtgaca      360



gagagaaggg cagaagtctc gagccgtacg gtggctgcac catctgtctt catcttcccg      420



ccatctgatg agcagttgaa atctggaact gcctctgttg tgtgcctgct gaataacttc      480



tatcccagag aggccaaagt acagtggaag gtggataacg ccctccaatc gggtaactcc      540



caggagagtg tcacagagca ggacagcaag gacagcacct acagcctcag cagcaccctg      600



acgctgagca aagcagacta cgagaaacac aaagtctacg cctgcgaagt cacccatcag      660



ggcctgagct cgcccgtcac aaagagcttc aacaggggag agtgtaccgt cctaggtcag      720



cccaaggcgg ccgctgaggt gcagctggtg gagtctgggg gaggcttagt gcagcctggg      780



gagtctctga cactctcctg tgtagttgct ggaagcatct tcagcttcgc catgagctgg      840



tatcgccagg ctccaggaaa agagcgcgaa ttggtcgcac gtattggttc ggatgatcgg      900



gtaacctacg cagattccgt gaagggccga tttaccatct ccagagacaa catcaagcgc      960



acggcgggcc tgcagatgaa cagcctgaaa cctgaggaca cggccgtcta ctactgcaat     1020



gcccaaacag atttgaggga ttggactgtg cgagagtact ggggccaggg gacccaggtc     1080



accgtctcct ca                                                         1092





<210>  51

<211>  364

<212>  PRT

<213>  Artificial Sequence



<220>

<223>  Synthetic polypeptide



<400>  51



Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu 

1               5                   10                  15      





Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser 

            20                  25                  30          





Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr Arg Met Ser Pro Ser 

        35                  40                  45              





Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro 

    50                  55                  60                  





Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp 

65                  70                  75                  80  





Phe His Met Ser Val Val Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr 

                85                  90                  95      





Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Ala Gln Ile Lys Glu Ser 

            100                 105                 110         





Leu Arg Ala Glu Leu Arg Val Thr Glu Arg Arg Ala Glu Val Ser Ser 

        115                 120                 125             





Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 

    130                 135                 140                 





Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 

145                 150                 155                 160 





Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 

                165                 170                 175     





Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 

            180                 185                 190         





Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 

        195                 200                 205             





Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 

    210                 215                 220                 





Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys Thr Val Leu Gly Gln 

225                 230                 235                 240 





Pro Lys Ala Ala Ala Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu 

                245                 250                 255     





Val Gln Pro Gly Glu Ser Leu Thr Leu Ser Cys Val Val Ala Gly Ser 

            260                 265                 270         





Ile Phe Ser Phe Ala Met Ser Trp Tyr Arg Gln Ala Pro Gly Lys Glu 

        275                 280                 285             





Arg Glu Leu Val Ala Arg Ile Gly Ser Asp Asp Arg Val Thr Tyr Ala 

    290                 295                 300                 





Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ile Lys Arg 

305                 310                 315                 320 





Thr Ala Gly Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val 

                325                 330                 335     





Tyr Tyr Cys Asn Ala Gln Thr Asp Leu Arg Asp Trp Thr Val Arg Glu 

            340                 345                 350         





Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 

        355                 360                 





<210>  52

<211>  1077

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic polynucleotide



<400>  52

gaagaggaac tccaggtgat ccagcccgac aagtccgtga gcgtggctgc tggagagagc       60



gccatcctgc actgtaccgt gacctccctg atccctgtgg gacccatcca gtggttcaga      120



ggagctggac ctgcaagaga actgatctac aaccagaagg agggacactt ccctagagtg      180



accacagtga gcgagtccac caagcggaat aacatggact tctccatcag aatcggcaac      240



atcacccctg ctgacgcagg cacctactat tgcgtgaagt tcaggaaggg cagccctgac      300



gatgtcgagt tcaagtccgg cgctggaacc gagctgagcg tgagagccaa gccctcgagc      360



tcgagccgta cggtggctgc accatctgtc ttcatcttcc cgccatctga tgagcagttg      420



aaatctggaa ctgcctctgt tgtgtgcctg ctgaataact tctatcccag agaggccaaa      480



gtacagtgga aggtggataa cgccctccaa tcgggtaact cccaggagag tgtcacagag      540



caggacagca aggacagcac ctacagcctc agcagcaccc tgacgctgag caaagcagac      600



tacgagaaac acaaagtcta cgcctgcgaa gtcacccatc agggcctgag ctcgcccgtc      660



acaaagagct tcaacagggg agagtgtacc gtcctaggtc agcccaaggc ggccgctgag      720



gtgcagctgg tggagtctgg gggaggcttg gtacagcctg gggggtccct gagactctcc      780



tgtgcagcct ctggattcac ctttgacgac tatggcatga gctgggtccg ccaggctcca      840



gggaagtggc tggagtgggt ctcagatatt agctggaatg gtggtagcac atactacgca      900



gactccgtga agggccggtt caccatctcc agagacaatg ccgagaacac gctgtatctg      960



caaatgaaca gcctgaaacc tgacgacacg gccgtgtatt actgtgcgaa aatgggtgaa     1020



gggggatggg gtgcaaatga ctactggggc caggggaccc aggtcaccgt gtcctca        1077





<210>  53

<211>  359

<212>  PRT

<213>  Artificial Sequence



<220>

<223>  Synthetic polypeptide



<400>  53



Glu Glu Glu Leu Gln Val Ile Gln Pro Asp Lys Ser Val Ser Val Ala 

1               5                   10                  15      





Ala Gly Glu Ser Ala Ile Leu His Cys Thr Val Thr Ser Leu Ile Pro 

            20                  25                  30          





Val Gly Pro Ile Gln Trp Phe Arg Gly Ala Gly Pro Ala Arg Glu Leu 

        35                  40                  45              





Ile Tyr Asn Gln Lys Glu Gly His Phe Pro Arg Val Thr Thr Val Ser 

    50                  55                  60                  





Glu Ser Thr Lys Arg Asn Asn Met Asp Phe Ser Ile Arg Ile Gly Asn 

65                  70                  75                  80  





Ile Thr Pro Ala Asp Ala Gly Thr Tyr Tyr Cys Val Lys Phe Arg Lys 

                85                  90                  95      





Gly Ser Pro Asp Asp Val Glu Phe Lys Ser Gly Ala Gly Thr Glu Leu 

            100                 105                 110         





Ser Val Arg Ala Lys Pro Ser Ser Ser Ser Arg Thr Val Ala Ala Pro 

        115                 120                 125             





Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr 

    130                 135                 140                 





Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys 

145                 150                 155                 160 





Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu 

                165                 170                 175     





Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser 

            180                 185                 190         





Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala 

        195                 200                 205             





Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe 

    210                 215                 220                 





Asn Arg Gly Glu Cys Thr Val Leu Gly Gln Pro Lys Ala Ala Ala Glu 

225                 230                 235                 240 





Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser 

                245                 250                 255     





Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr Gly 

            260                 265                 270         





Met Ser Trp Val Arg Gln Ala Pro Gly Lys Trp Leu Glu Trp Val Ser 

        275                 280                 285             





Asp Ile Ser Trp Asn Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys 

    290                 295                 300                 





Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Glu Asn Thr Leu Tyr Leu 

305                 310                 315                 320 





Gln Met Asn Ser Leu Lys Pro Asp Asp Thr Ala Val Tyr Tyr Cys Ala 

                325                 330                 335     





Lys Met Gly Glu Gly Gly Trp Gly Ala Asn Asp Tyr Trp Gly Gln Gly 

            340                 345                 350         





Thr Gln Val Thr Val Ser Ser 

        355                 





<210>  54

<211>  1074

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic polynucleotide



<400>  54

gaagaggaac tccaggtgat ccagcccgac aagtccgtga gcgtggctgc tggagagagc       60



gccatcctgc actgtaccgt gacctccctg atccctgtgg gacccatcca gtggttcaga      120



ggagctggac ctgcaagaga actgatctac aaccagaagg agggacactt ccctagagtg      180



accacagtga gcgagtccac caagcggaat aacatggact tctccatcag aatcggcaac      240



atcacccctg ctgacgcagg cacctactat tgcgtgaagt tcaggaaggg cagccctgac      300



gatgtcgagt tcaagtccgg cgctggaacc gagctgagcg tgagagccaa gccctcgagc      360



tcgagccgta cggtggctgc accatctgtc ttcatcttcc cgccatctga tgagcagttg      420



aaatctggaa ctgcctctgt tgtgtgcctg ctgaataact tctatcccag agaggccaaa      480



gtacagtgga aggtggataa cgccctccaa tcgggtaact cccaggagag tgtcacagag      540



caggacagca aggacagcac ctacagcctc agcagcaccc tgacgctgag caaagcagac      600



tacgagaaac acaaagtcta cgcctgcgaa gtcacccatc agggcctgag ctcgcccgtc      660



acaaagagct tcaacagggg agagtgtacc gtcctaggtc agcccaaggc ggccgctgag      720



gtgcagctgg tggagtctgg gggaggctta gtgcagcctg gggagtctct gacactctcc      780



tgtgtagttg ctggaagcat cttcagcttc gccatgagct ggtatcgcca ggctccagga      840



aaagagcgcg aattggtcgc acgtattggt tcggatgatc gggtaaccta cgcagattcc      900



gtgaagggcc gatttaccat ctccagagac aacatcaagc gcacggcggg cctgcagatg      960



aacagcctga aacctgagga cacggccgtc tactactgca atgcccaaac agatttgagg     1020



gattggactg tgcgagagta ctggggccag gggacccagg tcaccgtctc ctca           1074





<210>  55

<211>  358

<212>  PRT

<213>  Artificial Sequence



<220>

<223>  Synthetic polypeptide



<400>  55



Glu Glu Glu Leu Gln Val Ile Gln Pro Asp Lys Ser Val Ser Val Ala 

1               5                   10                  15      





Ala Gly Glu Ser Ala Ile Leu His Cys Thr Val Thr Ser Leu Ile Pro 

            20                  25                  30          





Val Gly Pro Ile Gln Trp Phe Arg Gly Ala Gly Pro Ala Arg Glu Leu 

        35                  40                  45              





Ile Tyr Asn Gln Lys Glu Gly His Phe Pro Arg Val Thr Thr Val Ser 

    50                  55                  60                  





Glu Ser Thr Lys Arg Asn Asn Met Asp Phe Ser Ile Arg Ile Gly Asn 

65                  70                  75                  80  





Ile Thr Pro Ala Asp Ala Gly Thr Tyr Tyr Cys Val Lys Phe Arg Lys 

                85                  90                  95      





Gly Ser Pro Asp Asp Val Glu Phe Lys Ser Gly Ala Gly Thr Glu Leu 

            100                 105                 110         





Ser Val Arg Ala Lys Pro Ser Ser Ser Ser Arg Thr Val Ala Ala Pro 

        115                 120                 125             





Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr 

    130                 135                 140                 





Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys 

145                 150                 155                 160 





Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu 

                165                 170                 175     





Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser 

            180                 185                 190         





Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala 

        195                 200                 205             





Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe 

    210                 215                 220                 





Asn Arg Gly Glu Cys Thr Val Leu Gly Gln Pro Lys Ala Ala Ala Glu 

225                 230                 235                 240 





Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Glu Ser 

                245                 250                 255     





Leu Thr Leu Ser Cys Val Val Ala Gly Ser Ile Phe Ser Phe Ala Met 

            260                 265                 270         





Ser Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Leu Val Ala Arg 

        275                 280                 285             





Ile Gly Ser Asp Asp Arg Val Thr Tyr Ala Asp Ser Val Lys Gly Arg 

    290                 295                 300                 





Phe Thr Ile Ser Arg Asp Asn Ile Lys Arg Thr Ala Gly Leu Gln Met 

305                 310                 315                 320 





Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Asn Ala Gln 

                325                 330                 335     





Thr Asp Leu Arg Asp Trp Thr Val Arg Glu Tyr Trp Gly Gln Gly Thr 

            340                 345                 350         





Gln Val Thr Val Ser Ser 

        355             





<210>  56

<211>  1074

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic polynucleotide



<400>  56

gaagaggaac tccaggtgat ccagcccgac aagtccgtga gcgtggctgc tggagagagc       60



gccatcctgc actgtaccgt gacctccctg atccctgtgg gacccatcca gtggttcaga      120



ggagctggac ctgcaagaga actgatctac aaccagaagg agggacactt ccctagagtg      180



accacagtga gcgagtccac caagcgggag aacatggact tctccatcag catctccaac      240



atcacccctg ctgacgcagg cacctactat tgcgtgaagt tcaggaaggg cagccctgac      300



accgagttca agtccggcgc tggaaccgag ctgagcgtga gagccaagcc ctcgagctcg      360



agccgtacgg tggctgcacc atctgtcttc atcttcccgc catctgatga gcagttgaaa      420



tctggaactg cctctgttgt gtgcctgctg aataacttct atcccagaga ggccaaagta      480



cagtggaagg tggataacgc cctccaatcg ggtaactccc aggagagtgt cacagagcag      540



gacagcaagg acagcaccta cagcctcagc agcaccctga cgctgagcaa agcagactac      600



gagaaacaca aagtctacgc ctgcgaagtc acccatcagg gcctgagctc gcccgtcaca      660



aagagcttca acaggggaga gtgtaccgtc ctaggtcagc ccaaggcggc cgctgaggtg      720



cagctggtgg agtctggggg aggcttggta cagcctgggg ggtccctgag actctcctgt      780



gcagcctctg gattcacctt tgacgactat ggcatgagct gggtccgcca ggctccaggg      840



aagtggctgg agtgggtctc agatattagc tggaatggtg gtagcacata ctacgcagac      900



tccgtgaagg gccggttcac catctccaga gacaatgccg agaacacgct gtatctgcaa      960



atgaacagcc tgaaacctga cgacacggcc gtgtattact gtgcgaaaat gggtgaaggg     1020



ggatggggtg caaatgacta ctggggccag gggacccagg tcaccgtgtc ctca           1074





<210>  57

<211>  358

<212>  PRT

<213>  Artificial Sequence



<220>

<223>  Synthetic polypeptide



<400>  57



Glu Glu Glu Leu Gln Val Ile Gln Pro Asp Lys Ser Val Ser Val Ala 

1               5                   10                  15      





Ala Gly Glu Ser Ala Ile Leu His Cys Thr Val Thr Ser Leu Ile Pro 

            20                  25                  30          





Val Gly Pro Ile Gln Trp Phe Arg Gly Ala Gly Pro Ala Arg Glu Leu 

        35                  40                  45              





Ile Tyr Asn Gln Lys Glu Gly His Phe Pro Arg Val Thr Thr Val Ser 

    50                  55                  60                  





Glu Ser Thr Lys Arg Glu Asn Met Asp Phe Ser Ile Ser Ile Ser Asn 

65                  70                  75                  80  





Ile Thr Pro Ala Asp Ala Gly Thr Tyr Tyr Cys Val Lys Phe Arg Lys 

                85                  90                  95      





Gly Ser Pro Asp Thr Glu Phe Lys Ser Gly Ala Gly Thr Glu Leu Ser 

            100                 105                 110         





Val Arg Ala Lys Pro Ser Ser Ser Ser Arg Thr Val Ala Ala Pro Ser 

        115                 120                 125             





Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala 

    130                 135                 140                 





Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val 

145                 150                 155                 160 





Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser 

                165                 170                 175     





Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr 

            180                 185                 190         





Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys 

        195                 200                 205             





Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn 

    210                 215                 220                 





Arg Gly Glu Cys Thr Val Leu Gly Gln Pro Lys Ala Ala Ala Glu Val 

225                 230                 235                 240 





Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu 

                245                 250                 255     





Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr Gly Met 

            260                 265                 270         





Ser Trp Val Arg Gln Ala Pro Gly Lys Trp Leu Glu Trp Val Ser Asp 

        275                 280                 285             





Ile Ser Trp Asn Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys Gly 

    290                 295                 300                 





Arg Phe Thr Ile Ser Arg Asp Asn Ala Glu Asn Thr Leu Tyr Leu Gln 

305                 310                 315                 320 





Met Asn Ser Leu Lys Pro Asp Asp Thr Ala Val Tyr Tyr Cys Ala Lys 

                325                 330                 335     





Met Gly Glu Gly Gly Trp Gly Ala Asn Asp Tyr Trp Gly Gln Gly Thr 

            340                 345                 350         





Gln Val Thr Val Ser Ser 

        355             





<210>  58

<211>  1071

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic polynucleotide



<400>  58

gaagaggaac tccaggtgat ccagcccgac aagtccgtga gcgtggctgc tggagagagc       60



gccatcctgc actgtaccgt gacctccctg atccctgtgg gacccatcca gtggttcaga      120



ggagctggac ctgcaagaga actgatctac aaccagaagg agggacactt ccctagagtg      180



accacagtga gcgagtccac caagcgggag aacatggact tctccatcag catctccaac      240



atcacccctg ctgacgcagg cacctactat tgcgtgaagt tcaggaaggg cagccctgac      300



accgagttca agtccggcgc tggaaccgag ctgagcgtga gagccaagcc ctcgagctcg      360



agccgtacgg tggctgcacc atctgtcttc atcttcccgc catctgatga gcagttgaaa      420



tctggaactg cctctgttgt gtgcctgctg aataacttct atcccagaga ggccaaagta      480



cagtggaagg tggataacgc cctccaatcg ggtaactccc aggagagtgt cacagagcag      540



gacagcaagg acagcaccta cagcctcagc agcaccctga cgctgagcaa agcagactac      600



gagaaacaca aagtctacgc ctgcgaagtc acccatcagg gcctgagctc gcccgtcaca      660



aagagcttca acaggggaga gtgtaccgtc ctaggtcagc ccaaggcggc cgctgaggtg      720



cagctggtgg agtctggggg aggcttagtg cagcctgggg agtctctgac actctcctgt      780



gtagttgctg gaagcatctt cagcttcgcc atgagctggt atcgccaggc tccaggaaaa      840



gagcgcgaat tggtcgcacg tattggttcg gatgatcggg taacctacgc agattccgtg      900



aagggccgat ttaccatctc cagagacaac atcaagcgca cggcgggcct gcagatgaac      960



agcctgaaac ctgaggacac ggccgtctac tactgcaatg cccaaacaga tttgagggat     1020



tggactgtgc gagagtactg gggccagggg acccaggtca ccgtctcctc a              1071





<210>  59

<211>  357

<212>  PRT

<213>  Artificial Sequence



<220>

<223>  Synthetic polypeptide



<400>  59



Glu Glu Glu Leu Gln Val Ile Gln Pro Asp Lys Ser Val Ser Val Ala 

1               5                   10                  15      





Ala Gly Glu Ser Ala Ile Leu His Cys Thr Val Thr Ser Leu Ile Pro 

            20                  25                  30          





Val Gly Pro Ile Gln Trp Phe Arg Gly Ala Gly Pro Ala Arg Glu Leu 

        35                  40                  45              





Ile Tyr Asn Gln Lys Glu Gly His Phe Pro Arg Val Thr Thr Val Ser 

    50                  55                  60                  





Glu Ser Thr Lys Arg Glu Asn Met Asp Phe Ser Ile Ser Ile Ser Asn 

65                  70                  75                  80  





Ile Thr Pro Ala Asp Ala Gly Thr Tyr Tyr Cys Val Lys Phe Arg Lys 

                85                  90                  95      





Gly Ser Pro Asp Thr Glu Phe Lys Ser Gly Ala Gly Thr Glu Leu Ser 

            100                 105                 110         





Val Arg Ala Lys Pro Ser Ser Ser Ser Arg Thr Val Ala Ala Pro Ser 

        115                 120                 125             





Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala 

    130                 135                 140                 





Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val 

145                 150                 155                 160 





Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser 

                165                 170                 175     





Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr 

            180                 185                 190         





Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys 

        195                 200                 205             





Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn 

    210                 215                 220                 





Arg Gly Glu Cys Thr Val Leu Gly Gln Pro Lys Ala Ala Ala Glu Val 

225                 230                 235                 240 





Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Glu Ser Leu 

                245                 250                 255     





Thr Leu Ser Cys Val Val Ala Gly Ser Ile Phe Ser Phe Ala Met Ser 

            260                 265                 270         





Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Leu Val Ala Arg Ile 

        275                 280                 285             





Gly Ser Asp Asp Arg Val Thr Tyr Ala Asp Ser Val Lys Gly Arg Phe 

    290                 295                 300                 





Thr Ile Ser Arg Asp Asn Ile Lys Arg Thr Ala Gly Leu Gln Met Asn 

305                 310                 315                 320 





Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Asn Ala Gln Thr 

                325                 330                 335     





Asp Leu Arg Asp Trp Thr Val Arg Glu Tyr Trp Gly Gln Gly Thr Gln 

            340                 345                 350         





Val Thr Val Ser Ser 

        355         





<210>  60

<211>  1344

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic polynucleotide



<400>  60

gaggtgcagc tggtggagtc tgggggaggc ttggtccagc ctggggggtc cctgagactc       60



tcctgtgcag cctctggatt caccttcagt agcagctaca tgagctgggt ccgccaggct      120



ccagggaagg ggctggagtg ggtctcaggc attaataccg atggtagctt cacacgctac      180



gcagactccg tgaagggccg attcaccatc tccagagaca atgccaagaa cacgctgtat      240



cttcaaatga acagcctgaa atctgaggac acggctctgt attactgtgc ggtaggcggc      300



gggttaggct atggacccag gggccaggga accctggtca ctgtctcctc agcgtcgacc      360



aagggcccat cggtcttccc gctagcaccc tcctccaaga gcacctctgg gggcacagcg      420



gccctgggct gcctggtcaa ggactacttc cccgaacctg tgacggtgtc gtggaactca      480



ggcgccctga ccagcggcgt gcacaccttc ccggctgtcc tacagtcctc aggactctac      540



tccctcagca gcgtggtgac cgtgccctcc agcagcttgg gcacccagac ctacatctgc      600



aacgtgaatc acaagcccag caacaccaag gtggacaaga aagttgagcc caaatcttgt      660



gacaaaactc acacatgccc accgtgccca gcacctgaag ctgctggggg accgtcagtc      720



ttcctcttcc ccccaaaacc caaggacacc ctcatgatct cccggacccc tgaggtcaca      780



tgcgtggtgg tggacgtgag ccacgaagac cctgaggtca agttcaactg gtacgtggac      840



ggcgtggagg tgcataatgc caagacaaag ccgcgggagg agcagtacaa cagcacgtac      900



cgggtggtca gcgtcctcac cgtcctgcac caggactggc tgaatggcaa ggagtacaag      960



tgcaaggtct ccaacaaagc cctcggagcc cccatcgaga aaaccatctc caaagccaaa     1020



gggcagcccc gagaaccaca ggtgtacacc ctgcccccat cccgggatga gctgaccaag     1080



aaccaggtca gcctgacctg cctggtcaaa ggcttctatc ccagcgacat cgccgtggag     1140



tgggagagca atgggcagcc ggagaacaac tacaagacca cgcctcccgt gctggactcc     1200



gacggctcct tcttcctcta cagcaagctc accgtggaca agagcaggtg gcagcagggg     1260



aacgtcttct catgctccgt gatgcatgag gctctgcaca accactacac gcagaagagc     1320



ctctccctgt ctccgggtaa atga                                            1344





<210>  61

<211>  447

<212>  PRT

<213>  Artificial Sequence



<220>

<223>  Synthetic polypeptide



<400>  61



Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 

1               5                   10                  15      





Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Ser 

            20                  25                  30          





Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 

        35                  40                  45              





Ser Gly Ile Asn Thr Asp Gly Ser Phe Thr Arg Tyr Ala Asp Ser Val 

    50                  55                  60                  





Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 

65                  70                  75                  80  





Leu Gln Met Asn Ser Leu Lys Ser Glu Asp Thr Ala Leu Tyr Tyr Cys 

                85                  90                  95      





Ala Val Gly Gly Gly Leu Gly Tyr Gly Pro Arg Gly Gln Gly Thr Leu 

            100                 105                 110         





Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 

        115                 120                 125             





Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys 

    130                 135                 140                 





Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 

145                 150                 155                 160 





Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 

                165                 170                 175     





Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 

            180                 185                 190         





Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn 

        195                 200                 205             





Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His 

    210                 215                 220                 





Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val 

225                 230                 235                 240 





Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 

                245                 250                 255     





Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 

            260                 265                 270         





Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 

        275                 280                 285             





Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 

    290                 295                 300                 





Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 

305                 310                 315                 320 





Cys Lys Val Ser Asn Lys Ala Leu Gly Ala Pro Ile Glu Lys Thr Ile 

                325                 330                 335     





Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 

            340                 345                 350         





Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 

        355                 360                 365             





Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 

    370                 375                 380                 





Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 

385                 390                 395                 400 





Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 

                405                 410                 415     





Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 

            420                 425                 430         





His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 

        435                 440                 445         





<210>  62

<211>  1098

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic polynucleotide



<400>  62

gaggtgcagc tggtggagtc tggaggaggc ttgatccagc ctggggggtc cctgagactc       60



tcctgtgcag cctctgggtt caccttcagt cgccgctgca tggcctggtt ccgccaggct      120



ccagggaagg agcgggagcg ggtcgcaaag ctgctgacca ctagcggtag cacatacctg      180



gcagactccg tgaagggccg attcaccatc tccagagaca attccaagaa cacggtgtat      240



cttcaaatga acagcctgag agccgaggac acggccgtgt attactgtgc ggccgacagc      300



ttcgaggacc ccacctgcac cctggtgacc agcagcggcg cctttcagta ctggggccag      360



ggcaccctgg tcaccgtgtc ctcacgtacg gtggctgcac catctgtctt catcttcccg      420



ccatctgatg agcagttgaa atctggaact gcctctgttg tgtgcctgct gaataacttc      480



tatcccagag aggccaaagt acagtggaag gtggataacg ccctccaatc gggtaactcc      540



caggagagtg tcacagagca ggacagcaag gacagcacct acagcctcag cagcaccctg      600



acgctgagca aagcagacta cgagaaacac aaagtctacg cctgcgaagt cacccatcag      660



ggcctgagct cgcccgtcac aaagagcttc aacaggggag agtgtaccgt cctaggtcag      720



cccaaggcgg ccgctgaggt gcagctggtg gagtctgggg gaggcttggt acagcctggg      780



gggtccctga gactctcctg tgcagcctct ggattcacct ttgacgacta tggcatgagc      840



tgggtccgcc aggctccagg gaagtggctg gagtgggtct cagatattag ctggaatggt      900



ggtagcacat actacgcaga ctccgtgaag ggccggttca ccatctccag agacaatgcc      960



gagaacacgc tgtatctgca aatgaacagc ctgaaacctg acgacacggc cgtgtattac     1020



tgtgcgaaaa tgggtgaagg gggatggggt gcaaatgact actggggcca ggggacccag     1080



gtcaccgtgt cctcataa                                                   1098





<210>  63

<211>  365

<212>  PRT

<213>  Artificial Sequence



<220>

<223>  Synthetic polypeptide



<400>  63



Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Ile Gln Pro Gly Gly 

1               5                   10                  15      





Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Arg Arg 

            20                  25                  30          





Cys Met Ala Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Arg Val 

        35                  40                  45              





Ala Lys Leu Leu Thr Thr Ser Gly Ser Thr Tyr Leu Ala Asp Ser Val 

    50                  55                  60                  





Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr 

65                  70                  75                  80  





Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 

                85                  90                  95      





Ala Ala Asp Ser Phe Glu Asp Pro Thr Cys Thr Leu Val Thr Ser Ser 

            100                 105                 110         





Gly Ala Phe Gln Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 

        115                 120                 125             





Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 

    130                 135                 140                 





Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 

145                 150                 155                 160 





Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 

                165                 170                 175     





Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 

            180                 185                 190         





Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 

        195                 200                 205             





Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 

    210                 215                 220                 





Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys Thr Val Leu Gly Gln 

225                 230                 235                 240 





Pro Lys Ala Ala Ala Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu 

                245                 250                 255     





Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 

            260                 265                 270         





Thr Phe Asp Asp Tyr Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys 

        275                 280                 285             





Trp Leu Glu Trp Val Ser Asp Ile Ser Trp Asn Gly Gly Ser Thr Tyr 

    290                 295                 300                 





Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala 

305                 310                 315                 320 





Glu Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Lys Pro Asp Asp Thr 

                325                 330                 335     





Ala Val Tyr Tyr Cys Ala Lys Met Gly Glu Gly Gly Trp Gly Ala Asn 

            340                 345                 350         





Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 

        355                 360                 365 





<210>  64

<211>  1095

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic polynucleotide



<400>  64

gaggtgcagc tggtggagtc tggaggaggc ttgatccagc ctggggggtc cctgagactc       60



tcctgtgcag cctctgggtt caccttcagt cgccgctgca tggcctggtt ccgccaggct      120



ccagggaagg agcgggagcg ggtcgcaaag ctgctgacca ctagcggtag cacatacctg      180



gcagactccg tgaagggccg attcaccatc tccagagaca attccaagaa cacggtgtat      240



cttcaaatga acagcctgag agccgaggac acggccgtgt attactgtgc ggccgacagc      300



ttcgaggacc ccacctgcac cctggtgacc agcagcggcg cctttcagta ctggggccag      360



ggcaccctgg tcaccgtgtc ctcacgtacg gtggctgcac catctgtctt catcttcccg      420



ccatctgatg agcagttgaa atctggaact gcctctgttg tgtgcctgct gaataacttc      480



tatcccagag aggccaaagt acagtggaag gtggataacg ccctccaatc gggtaactcc      540



caggagagtg tcacagagca ggacagcaag gacagcacct acagcctcag cagcaccctg      600



acgctgagca aagcagacta cgagaaacac aaagtctacg cctgcgaagt cacccatcag      660



ggcctgagct cgcccgtcac aaagagcttc aacaggggag agtgtaccgt cctaggtcag      720



cccaaggcgg ccgctgaggt gcagctggtg gagtctgggg gaggcttagt gcagcctggg      780



gagtctctga cactctcctg tgtagttgct ggaagcatct tcagcttcgc catgagctgg      840



tatcgccagg ctccaggaaa agagcgcgaa ttggtcgcac gtattggttc ggatgatcgg      900



gtaacctacg cagattccgt gaagggccga tttaccatct ccagagacaa catcaagcgc      960



acggcgggcc tgcagatgaa cagcctgaaa cctgaggaca cggccgtcta ctactgcaat     1020



gcccaaacag atttgaggga ttggactgtg cgagagtact ggggccaggg gacccaggtc     1080



accgtctcct cataa                                                      1095





<210>  65

<211>  364

<212>  PRT

<213>  Artificial Sequence



<220>

<223>  Synthetic polypeptide



<400>  65



Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Ile Gln Pro Gly Gly 

1               5                   10                  15      





Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Arg Arg 

            20                  25                  30          





Cys Met Ala Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Arg Val 

        35                  40                  45              





Ala Lys Leu Leu Thr Thr Ser Gly Ser Thr Tyr Leu Ala Asp Ser Val 

    50                  55                  60                  





Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr 

65                  70                  75                  80  





Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 

                85                  90                  95      





Ala Ala Asp Ser Phe Glu Asp Pro Thr Cys Thr Leu Val Thr Ser Ser 

            100                 105                 110         





Gly Ala Phe Gln Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 

        115                 120                 125             





Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 

    130                 135                 140                 





Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 

145                 150                 155                 160 





Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 

                165                 170                 175     





Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 

            180                 185                 190         





Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 

        195                 200                 205             





Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 

    210                 215                 220                 





Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys Thr Val Leu Gly Gln 

225                 230                 235                 240 





Pro Lys Ala Ala Ala Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu 

                245                 250                 255     





Val Gln Pro Gly Glu Ser Leu Thr Leu Ser Cys Val Val Ala Gly Ser 

            260                 265                 270         





Ile Phe Ser Phe Ala Met Ser Trp Tyr Arg Gln Ala Pro Gly Lys Glu 

        275                 280                 285             





Arg Glu Leu Val Ala Arg Ile Gly Ser Asp Asp Arg Val Thr Tyr Ala 

    290                 295                 300                 





Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ile Lys Arg 

305                 310                 315                 320 





Thr Ala Gly Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val 

                325                 330                 335     





Tyr Tyr Cys Asn Ala Gln Thr Asp Leu Arg Asp Trp Thr Val Arg Glu 

            340                 345                 350         





Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 

        355                 360                 





<210>  66

<211>  1362

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic polynucleotide



<400>  66

caggtgcagc tggtgcagtc tgggggagga ttggtgcagg ctgggggctc tctgagactc       60



tcctgtgcag cctctggacg caccttcagt agttatgcca tggcctggtt ccgccaggct      120



ccagggaagg agcgtgagtt tgtagcagct attagctgga gtggtgcaaa catatacgtt      180



gcagactccg tgaagggccg attcaccatc tccagagaca acgccaagga cacggtgtat      240



ctgcaaatga acagcctgaa acctgaggac acggccgttt attactgtgc agtaaagctc      300



ggtttcgcac ctgtagaaga aaggcagtat gactactggg gccaggggac ccaggtcacc      360



gtctcctcag cgtcgaccaa gggcccatcg gtcttcccgc tagcaccctc ctccaagagc      420



acctctgggg gcacagcggc cctgggctgc ctggtcaagg actacttccc cgaacctgtg      480



acggtgtcgt ggaactcagg cgccctgacc agcggcgtgc acaccttccc ggctgtccta      540



cagtcctcag gactctactc cctcagcagc gtggtgaccg tgccctccag cagcttgggc      600



acccagacct acatctgcaa cgtgaatcac aagcccagca acaccaaggt ggacaagaaa      660



gttgagccca aatcttgtga caaaactcac acatgcccac cgtgcccagc acctgaagct      720



gctgggggac cgtcagtctt cctcttcccc ccaaaaccca aggacaccct catgatctcc      780



cggacccctg aggtcacatg cgtggtggtg gacgtgagcc acgaagaccc tgaggtcaag      840



ttcaactggt acgtggacgg cgtggaggtg cataatgcca agacaaagcc gcgggaggag      900



cagtacaaca gcacgtaccg ggtggtcagc gtcctcaccg tcctgcacca ggactggctg      960



aatggcaagg agtacaagtg caaggtctcc aacaaagccc tcggagcccc catcgagaaa     1020



accatctcca aagccaaagg gcagccccga gaaccacagg tgtacaccct gcccccatcc     1080



cgggatgagc tgaccaagaa ccaggtcagc ctgacctgcc tggtcaaagg cttctatccc     1140



agcgacatcg ccgtggagtg ggagagcaat gggcagccgg agaacaacta caagaccacg     1200



cctcccgtgc tggactccga cggctccttc ttcctctaca gcaagctcac cgtggacaag     1260



agcaggtggc agcaggggaa cgtcttctca tgctccgtga tgcatgaggc tctgcacaac     1320



cactacacgc agaagagcct ctccctgtct ccgggtaaat ga                        1362





<210>  67

<211>  453

<212>  PRT

<213>  Artificial Sequence



<220>

<223>  Synthetic polypeptide



<400>  67



Gln Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 

1               5                   10                  15      





Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Ser Ser Tyr 

            20                  25                  30          





Ala Met Ala Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 

        35                  40                  45              





Ala Ala Ile Ser Trp Ser Gly Ala Asn Ile Tyr Val Ala Asp Ser Val 

    50                  55                  60                  





Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asp Thr Val Tyr 

65                  70                  75                  80  





Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 

                85                  90                  95      





Ala Val Lys Leu Gly Phe Ala Pro Val Glu Glu Arg Gln Tyr Asp Tyr 

            100                 105                 110         





Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Ala Ser Thr Lys Gly 

        115                 120                 125             





Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly 

    130                 135                 140                 





Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val 

145                 150                 155                 160 





Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe 

                165                 170                 175     





Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val 

            180                 185                 190         





Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val 

        195                 200                 205             





Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys 

    210                 215                 220                 





Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala 

225                 230                 235                 240 





Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 

                245                 250                 255     





Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 

            260                 265                 270         





Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 

        275                 280                 285             





Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 

    290                 295                 300                 





Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 

305                 310                 315                 320 





Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Gly Ala 

                325                 330                 335     





Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 

            340                 345                 350         





Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln 

        355                 360                 365             





Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 

    370                 375                 380                 





Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 

385                 390                 395                 400 





Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 

                405                 410                 415     





Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 

            420                 425                 430         





Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 

        435                 440                 445             





Leu Ser Pro Gly Lys 

    450             





<210>  68

<211>  1368

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic polynucleotide



<400>  68

gatgtgcagc tgcaggcktc tggaggaggc tcggtgcagg cgggagggtc tctgaggctc       60



tcctgtgcag cggatgcata catctacagt aggaaccgtc tggcctggtt ccgccggtct      120



ccaggaaagg accgcgaggg agtcgcaaca atgtgtgacg gaaacacata ctatagcgac      180



tccgcgaagg gccgattcac catctcccaa gacaacgcca agaacgagct aattctgcaa      240



atgagcagcc tgagacctga ggacactgcc acgtacttct gtgcaggccg accgtcttcc      300



attgaaaatt gtggtagcct cagtctgcat gattataact tctggggcca agggacccag      360



gtcaccgtct cctcagcgtc gaccaagggc ccatcggtct tcccgctagc accctcctcc      420



aagagcacct ctgggggcac agcggccctg ggctgcctgg tcaaggacta cttccccgaa      480



cctgtgacgg tgtcgtggaa ctcaggcgcc ctgaccagcg gcgtgcacac cttcccggct      540



gtcctacagt cctcaggact ctactccctc agcagcgtgg tgaccgtgcc ctccagcagc      600



ttgggcaccc agacctacat ctgcaacgtg aatcacaagc ccagcaacac caaggtggac      660



aagaaagttg agcccaaatc ttgtgacaaa actcacacat gcccaccgtg cccagcacct      720



gaagctgctg ggggaccgtc agtcttcctc ttccccccaa aacccaagga caccctcatg      780



atctcccgga cccctgaggt cacatgcgtg gtggtggacg tgagccacga agaccctgag      840



gtcaagttca actggtacgt ggacggcgtg gaggtgcata atgccaagac aaagccgcgg      900



gaggagcagt acaacagcac gtaccgggtg gtcagcgtcc tcaccgtcct gcaccaggac      960



tggctgaatg gcaaggagta caagtgcaag gtctccaaca aagccctcgg agcccccatc     1020



gagaaaacca tctccaaagc caaagggcag ccccgagaac cacaggtgta caccctgccc     1080



ccatcccggg atgagctgac caagaaccag gtcagcctga cctgcctggt caaaggcttc     1140



tatcccagcg acatcgccgt ggagtgggag agcaatgggc agccggagaa caactacaag     1200



accacgcctc ccgtgctgga ctccgacggc tccttcttcc tctacagcaa gctcaccgtg     1260



gacaagagca ggtggcagca ggggaacgtc ttctcatgct ccgtgatgca tgaggctctg     1320



cacaaccact acacgcagaa gagcctctcc ctgtctccgg gtaaatga                  1368





<210>  69

<211>  455

<212>  PRT

<213>  Artificial Sequence



<220>

<223>  Synthetic polypeptide



<400>  69



Asp Val Gln Leu Gln Ala Ser Gly Gly Gly Ser Val Gln Ala Gly Gly 

1               5                   10                  15      





Ser Leu Arg Leu Ser Cys Ala Ala Asp Ala Tyr Ile Tyr Ser Arg Asn 

            20                  25                  30          





Arg Leu Ala Trp Phe Arg Arg Ser Pro Gly Lys Asp Arg Glu Gly Val 

        35                  40                  45              





Ala Thr Met Cys Asp Gly Asn Thr Tyr Tyr Ser Asp Ser Ala Lys Gly 

    50                  55                  60                  





Arg Phe Thr Ile Ser Gln Asp Asn Ala Lys Asn Glu Leu Ile Leu Gln 

65                  70                  75                  80  





Met Ser Ser Leu Arg Pro Glu Asp Thr Ala Thr Tyr Phe Cys Ala Gly 

                85                  90                  95      





Arg Pro Ser Ser Ile Glu Asn Cys Gly Ser Leu Ser Leu His Asp Tyr 

            100                 105                 110         





Asn Phe Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Ala Ser Thr 

        115                 120                 125             





Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser 

    130                 135                 140                 





Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu 

145                 150                 155                 160 





Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His 

                165                 170                 175     





Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser 

            180                 185                 190         





Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys 

        195                 200                 205             





Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu 

    210                 215                 220                 





Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro 

225                 230                 235                 240 





Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 

                245                 250                 255     





Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 

            260                 265                 270         





Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 

        275                 280                 285             





Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 

    290                 295                 300                 





Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 

305                 310                 315                 320 





Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 

                325                 330                 335     





Gly Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 

            340                 345                 350         





Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys 

        355                 360                 365             





Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 

    370                 375                 380                 





Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 

385                 390                 395                 400 





Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 

                405                 410                 415     





Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 

            420                 425                 430         





Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 

        435                 440                 445             





Leu Ser Leu Ser Pro Gly Lys 

    450                 455 





