                         SEQUENCE LISTING

<110>  Antibody BioPharm, Inc.
 
<120>  GUIDED COMBINATIONAL THERAPEUTIC ANTIBODY

<130>  1023-701WO

<140>  TBA
<141>  2018-06-07

<150>  US 62/516,583
<151>  2017-06-07

<160>  69    

<170>  PatentIn version 3.5

<210>  1
<211>  360
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  1
gaggtgcagc tggtggagtc tggaggaggc ttggtccagc ctggggggtc cctgagactc       60

tcctgtgcag cctctgggtt caacatcaaa gacacctaca tccactgggt ccgccaggct      120

ccagggaagg agcgggagtg ggtcgcccgg atttatccca caaacggtta cacacggtac      180

gcagactccg tgaagggccg attcaccatc tccagagaca atgccaagga cactgtgtat      240

cttcaaatga acagcctgag agccgaggac acggccgtgt attactgttc ccggtgggga      300

ggggacgggt tctatgctat ggactactgg ggccaaggaa cactggtcac cgtctcgagc      360


<210>  2
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  2

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile Lys Asp Thr 
            20                  25                  30          


Tyr Ile His Trp Val Arg Gln Ala Pro Gly Lys Glu Arg Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Tyr Pro Thr Asn Gly Tyr Thr Arg Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asp Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ser Arg Trp Gly Gly Asp Gly Phe Tyr Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  3
<211>  369
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  3
caggtgcagc tggtgcagtc tgggggagga ttggtgcagg ctgggggctc tctgagactc       60

tcctgtgcag cctctggacg caccttcagt agttatgcca tggcctggtt ccgccaggct      120

ccagggaagg agcgtgagtt tgtagcagct attagctgga gtggtgcaaa catatacgtt      180

gcagactccg tgaagggccg attcaccatc tccagagaca acgccaagga cacggtgtat      240

ctgcaaatga acagcctgaa acctgaggac acggccgttt attactgtgc agtaaagctc      300

ggtttcgcac ctgtagaaga aaggcagtat gactactggg gccaggggac ccaggtcacc      360

gtctcgagc                                                              369


<210>  4
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  4

Gln Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ala Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Ser Trp Ser Gly Ala Asn Ile Tyr Val Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asp Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Val Lys Leu Gly Phe Ala Pro Val Glu Glu Arg Gln Tyr Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120             


<210>  5
<211>  351
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  5
gaagaggaac tccaggtgat ccagcccgac aagtccgtga gcgtggctgc tggagagagc       60

gccatcctgc actgtaccgt gacctccctg atccctgtgg gacccatcca gtggttcaga      120

ggagctggac ctgcaagaga actgatctac aaccagaagg agggacactt ccctagagtg      180

accacagtga gcgagtccac caagcgggag aacatggact tctccatcag catctccaac      240

atcacccctg ctgacgcagg cacctactat tgcgtgaagt tcaggaaggg cagccctgac      300

accgagttca agtccggcgc tggaaccgag ctgagcgtga gagccaagcc c               351


<210>  6
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  6

Glu Glu Glu Leu Gln Val Ile Gln Pro Asp Lys Ser Val Ser Val Ala 
1               5                   10                  15      


Ala Gly Glu Ser Ala Ile Leu His Cys Thr Val Thr Ser Leu Ile Pro 
            20                  25                  30          


Val Gly Pro Ile Gln Trp Phe Arg Gly Ala Gly Pro Ala Arg Glu Leu 
        35                  40                  45              


Ile Tyr Asn Gln Lys Glu Gly His Phe Pro Arg Val Thr Thr Val Ser 
    50                  55                  60                  


Glu Ser Thr Lys Arg Glu Asn Met Asp Phe Ser Ile Ser Ile Ser Asn 
65                  70                  75                  80  


Ile Thr Pro Ala Asp Ala Gly Thr Tyr Tyr Cys Val Lys Phe Arg Lys 
                85                  90                  95      


Gly Ser Pro Asp Thr Glu Phe Lys Ser Gly Ala Gly Thr Glu Leu Ser 
            100                 105                 110         


Val Arg Ala Lys Pro 
        115         


<210>  7
<211>  354
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  7
gaagaggaac tccaggtgat ccagcccgac aagtccgtga gcgtggctgc tggagagagc       60

gccatcctgc actgtaccgt gacctccctg atccctgtgg gacccatcca gtggttcaga      120

ggagctggac ctgcaagaga actgatctac aaccagaagg agggacactt ccctagagtg      180

accacagtga gcgagtccac caagcggaat aacatggact tctccatcag aatcggcaac      240

atcacccctg ctgacgcagg cacctactat tgcgtgaagt tcaggaaggg cagccctgac      300

gatgtcgagt tcaagtccgg cgctggaacc gagctgagcg tgagagccaa gccc            354


<210>  8
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  8

Glu Glu Glu Leu Gln Val Ile Gln Pro Asp Lys Ser Val Ser Val Ala 
1               5                   10                  15      


Ala Gly Glu Ser Ala Ile Leu His Cys Thr Val Thr Ser Leu Ile Pro 
            20                  25                  30          


Val Gly Pro Ile Gln Trp Phe Arg Gly Ala Gly Pro Ala Arg Glu Leu 
        35                  40                  45              


Ile Tyr Asn Gln Lys Glu Gly His Phe Pro Arg Val Thr Thr Val Ser 
    50                  55                  60                  


Glu Ser Thr Lys Arg Asn Asn Met Asp Phe Ser Ile Arg Ile Gly Asn 
65                  70                  75                  80  


Ile Thr Pro Ala Asp Ala Gly Thr Tyr Tyr Cys Val Lys Phe Arg Lys 
                85                  90                  95      


Gly Ser Pro Asp Asp Val Glu Phe Lys Ser Gly Ala Gly Thr Glu Leu 
            100                 105                 110         


Ser Val Arg Ala Lys Pro 
        115             


<210>  9
<211>  378
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  9
gactccccag acaggccctg gaaccccccc accttctccc cagccctgct cgtggtgacc       60

gaaggggaca acgccacctt cacctgtagc ttctccaaca catcggagag cttcgtgcta      120

aactggtatc gcatgagccc cagcaaccag acggacaagc tggccgcctt ccccgaggac      180

cgcagccagc ccggccagga ctgccgcttc cgtgtcacac aactgcccaa cgggcgtgac      240

ttccacatga gcgtggtcag agcccggcgc aatgacagcg gcacctacct ctgtggagct      300

atctcccggg cccccaaggc gcagatcaaa gagagcctgc gggcagagct gagggtgaca      360

gagagaaggg cagaagtc                                                    378


<210>  10
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  10

Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu 
1               5                   10                  15      


Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser 
            20                  25                  30          


Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr Arg Met Ser Pro Ser 
        35                  40                  45              


Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro 
    50                  55                  60                  


Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp 
65                  70                  75                  80  


Phe His Met Ser Val Val Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr 
                85                  90                  95      


Leu Cys Gly Ala Ile Ser Arg Ala Pro Lys Ala Gln Ile Lys Glu Ser 
            100                 105                 110         


Leu Arg Ala Glu Leu Arg Val Thr Glu Arg Arg Ala Glu Val 
        115                 120                 125     


<210>  11
<211>  378
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  11
gactccccag acagaccttg gaacccacct accttctccc cagcactgct cgtcgtgacc       60

gaaggagaca acgcaacctt cacctgtagc ttctccaaca catcggagag cttcgtgcta      120

aactggtatc gcatgagccc tagcaaccag actgacaagc tggcagcctt ccctgaggac      180

cgcagccagc caggacagga ctgccgcttc cgtgtcacac aactgcccaa cggacgtgac      240

ttccacatga gcgtggtcag agcaagacgc aatgacagcg gcacctacct ctgtggagct      300

atctccctgg ctcccaaggc acagatcaaa gagagcctga gggcagagct gagggtgaca      360

gagagaaggg cagaagtc                                                    378


<210>  12
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  12

Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu 
1               5                   10                  15      


Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser 
            20                  25                  30          


Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr Arg Met Ser Pro Ser 
        35                  40                  45              


Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro 
    50                  55                  60                  


Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp 
65                  70                  75                  80  


Phe His Met Ser Val Val Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr 
                85                  90                  95      


Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Ala Gln Ile Lys Glu Ser 
            100                 105                 110         


Leu Arg Ala Glu Leu Arg Val Thr Glu Arg Arg Ala Glu Val 
        115                 120                 125     


<210>  13
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  13
tcgagcgcgt cgacc                                                        15


<210>  14
<211>  12
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  14
tcgagccgta cg                                                           12


<210>  15
<211>  9
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  15
gcgtcgacc                                                                9


<210>  16
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  16
gcgtcgaccg gcggtggtgg gtcg                                              24


<210>  17
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  17
gcgtcgaccg gcggaggtgg gtccggggga ggcggaagc                              39


<210>  18
<211>  54
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  18
gcgtcgaccg gcggaggtgg gtccggggga ggcggaagcg gagggggcgg atct             54


<210>  19
<211>  63
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  19
gcgtcgaccg gcggaggtgg gtccggggga ggcggaagcg gagggggcgg atctggaggt       60

agc                                                                     63


<210>  20
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  20
tcgagcgcgt cgaccccact cgga                                              24


<210>  21
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  21
tcgagcgcgt cgaccccact cggagacacc aca                                    33


<210>  22
<211>  45
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  22
tcgagcgcgt cgaccccact cggagacacc acacacacca gccct                       45


<210>  23
<211>  54
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  23
tcgagcgcgt cgaccccact cggagacacc acacacacca gccctagatc tcca             54


<210>  24
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  24
tcgagcgcgt cgaccagccc tagatctcca gagcccaaga gctccgacac acccccacct       60


<210>  25
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  25
tcgagcgata agacccacac t                                                 21


<210>  26
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  26
tcgagcgata agacccacac tgcgtcgacc                                        30


<210>  27
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  27
tcgagcgaca agacacgtac ggcgtcgacc                                        30


<210>  28
<211>  1350
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  28
gaagaggaac tccaggtgat ccagcccgac aagtccgtga gcgtggctgc tggagagagc       60

gccatcctgc actgtaccgt gacctccctg atccctgtgg gacccatcca gtggttcaga      120

ggagctggac ctgcaagaga actgatctac aaccagaagg agggacactt ccctagagtg      180

accacagtga gcgagtccac caagcggaat aacatggact tctccatcag aatcggcaac      240

atcacccctg ctgacgcagg cacctactat tgcgtgaagt tcaggaaggg cagccctgac      300

gatgtcgagt tcaagtccgg cgctggaacc gagctgagcg tgagagccaa gccctcgagc      360

gcgtcgacca agggcccatc ggtcttcccg ctagcaccct cctccaagag cacctctggg      420

ggcacagcgg ccctgggctg cctggtcaag gactacttcc ccgaacctgt gacggtgtcg      480

tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca      540

ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacccagacc      600

tacatctgca acgtgaatca caagcccagc aacaccaagg tggacaagaa agttgagccc      660

aaatcttgtg acaaaactca cacatgccca ccgtgcccag cacctgaagc tgctggggga      720

ccgtcagtct tcctcttccc cccaaaaccc aaggacaccc tcatgatctc ccggacccct      780

gaggtcacat gcgtggtggt ggacgtgagc cacgaagacc ctgaggtcaa gttcaactgg      840

tacgtggacg gcgtggaggt gcataatgcc aagacaaagc cgcgggagga gcagtacaac      900

agcacgtacc gggtggtcag cgtcctcacc gtcctgcacc aggactggct gaatggcaag      960

gagtacaagt gcaaggtctc caacaaagcc ctcggagccc ccatcgagaa aaccatctcc     1020

aaagccaaag ggcagccccg agaaccacag gtgtacaccc tgcccccatc cagggatgag     1080

ctgaccaaga accaggtcag cctgacctgc ctggtcaaag gcttctatcc cagcgacatc     1140

gccgtggagt gggagagcaa tgggcagccg gagaacaact acaagaccac gcctcccgtg     1200

ctggactccg acggctcctt cttcctctac agcaagctca ccgtggacaa gagcaggtgg     1260

cagcagggga acgtcttctc atgctccgtg atgcatgagg ctctgcacaa ccactacacg     1320

cagaagagcc tctccctgtc tcccgggaaa                                      1350


<210>  29
<211>  450
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  29

Glu Glu Glu Leu Gln Val Ile Gln Pro Asp Lys Ser Val Ser Val Ala 
1               5                   10                  15      


Ala Gly Glu Ser Ala Ile Leu His Cys Thr Val Thr Ser Leu Ile Pro 
            20                  25                  30          


Val Gly Pro Ile Gln Trp Phe Arg Gly Ala Gly Pro Ala Arg Glu Leu 
        35                  40                  45              


Ile Tyr Asn Gln Lys Glu Gly His Phe Pro Arg Val Thr Thr Val Ser 
    50                  55                  60                  


Glu Ser Thr Lys Arg Asn Asn Met Asp Phe Ser Ile Arg Ile Gly Asn 
65                  70                  75                  80  


Ile Thr Pro Ala Asp Ala Gly Thr Tyr Tyr Cys Val Lys Phe Arg Lys 
                85                  90                  95      


Gly Ser Pro Asp Asp Val Glu Phe Lys Ser Gly Ala Gly Thr Glu Leu 
            100                 105                 110         


Ser Val Arg Ala Lys Pro Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly 
225                 230                 235                 240 


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                245                 250                 255     


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
            260                 265                 270         


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        275                 280                 285             


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
    290                 295                 300                 


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
305                 310                 315                 320 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Gly Ala Pro Ile Glu 
                325                 330                 335     


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            340                 345                 350         


Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 
        355                 360                 365             


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    370                 375                 380                 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
385                 390                 395                 400 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
                405                 410                 415     


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
            420                 425                 430         


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
        435                 440                 445             


Gly Lys 
    450 


<210>  30
<211>  705
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  30
gactccccag acaggccctg gaaccccccc accttctccc cagccctgct cgtggtgacc       60

gaaggggaca acgccacctt cacctgtagc ttctccaaca catcggagag cttcgtgcta      120

aactggtatc gcatgagccc cagcaaccag acggacaagc tggccgcctt ccccgaggac      180

cgcagccagc ccggccagga ctgccgcttc cgtgtcacac aactgcccaa cgggcgtgac      240

ttccacatga gcgtggtcag agcccggcgc aatgacagcg gcacctacct ctgtggagct      300

atctcccggg cccccaaggc gcagatcaaa gagagcctgc gggcagagct gagggtgaca      360

gagagaaggg cagaagtctc gagccgtacg gtggctgcac catctgtctt catcttcccg      420

ccatctgatg agcagttgaa atctggaact gcctctgttg tgtgcctgct gaataacttc      480

tatcccagag aggccaaagt acagtggaag gtggataacg ccctccaatc gggtaactcc      540

caggagagtg tcacagagca ggacagcaag gacagcacct acagcctcag cagcaccctg      600

acgctgagca aagcagacta cgagaaacac aaagtctacg cctgcgaagt cacccatcag      660

ggcctgagct cgcccgtcac aaagagcttc aacaggggag agtgt                      705


<210>  31
<211>  235
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  31

Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu 
1               5                   10                  15      


Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser 
            20                  25                  30          


Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr Arg Met Ser Pro Ser 
        35                  40                  45              


Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro 
    50                  55                  60                  


Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp 
65                  70                  75                  80  


Phe His Met Ser Val Val Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr 
                85                  90                  95      


Leu Cys Gly Ala Ile Ser Arg Ala Pro Lys Ala Gln Ile Lys Glu Ser 
            100                 105                 110         


Leu Arg Ala Glu Leu Arg Val Thr Glu Arg Arg Ala Glu Val Ser Ser 
        115                 120                 125             


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
    130                 135                 140                 


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
145                 150                 155                 160 


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
                165                 170                 175     


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
            180                 185                 190         


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
        195                 200                 205             


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
    210                 215                 220                 


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 235 


<210>  32
<211>  1347
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  32
gaagaggaac tccaggtgat ccagcccgac aagtccgtga gcgtggctgc tggagagagc       60

gccatcctgc actgtaccgt gacctccctg atccctgtgg gacccatcca gtggttcaga      120

ggagctggac ctgcaagaga actgatctac aaccagaagg agggacactt ccctagagtg      180

accacagtga gcgagtccac caagcgggag aacatggact tctccatcag catctccaac      240

atcacccctg ctgacgcagg cacctactat tgcgtgaagt tcaggaaggg cagccctgac      300

accgagttca agtccggcgc tggaaccgag ctgagcgtga gagccaagcc ctcgagcgcg      360

tcgaccaagg gcccatcggt cttcccgcta gcaccctcct ccaagagcac ctctgggggc      420

acagcggccc tgggctgcct ggtcaaggac tacttccccg aacctgtgac ggtgtcgtgg      480

aactcaggcg ccctgaccag cggcgtgcac accttcccgg ctgtcctaca gtcctcagga      540

ctctactccc tcagcagcgt ggtgaccgtg ccctccagca gcttgggcac ccagacctac      600

atctgcaacg tgaatcacaa gcccagcaac accaaggtgg acaagaaagt tgagcccaaa      660

tcttgtgaca aaactcacac atgcccaccg tgcccagcac ctgaagctgc tgggggaccg      720

tcagtcttcc tcttcccccc aaaacccaag gacaccctca tgatctcccg gacccctgag      780

gtcacatgcg tggtggtgga cgtgagccac gaagaccctg aggtcaagtt caactggtac      840

gtggacggcg tggaggtgca taatgccaag acaaagccgc gggaggagca gtacaacagc      900

acgtaccggg tggtcagcgt cctcaccgtc ctgcaccagg actggctgaa tggcaaggag      960

tacaagtgca aggtctccaa caaagccctc ggagccccca tcgagaaaac catctccaaa     1020

gccaaagggc agccccgaga accacaggtg tacaccctgc ccccatccag ggatgagctg     1080

accaagaacc aggtcagcct gacctgcctg gtcaaaggct tctatcccag cgacatcgcc     1140

gtggagtggg agagcaatgg gcagccggag aacaactaca agaccacgcc tcccgtgctg     1200

gactccgacg gctccttctt cctctacagc aagctcaccg tggacaagag caggtggcag     1260

caggggaacg tcttctcatg ctccgtgatg catgaggctc tgcacaacca ctacacgcag     1320

aagagcctct ccctgtctcc cgggaaa                                         1347


<210>  33
<211>  449
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  33

Glu Glu Glu Leu Gln Val Ile Gln Pro Asp Lys Ser Val Ser Val Ala 
1               5                   10                  15      


Ala Gly Glu Ser Ala Ile Leu His Cys Thr Val Thr Ser Leu Ile Pro 
            20                  25                  30          


Val Gly Pro Ile Gln Trp Phe Arg Gly Ala Gly Pro Ala Arg Glu Leu 
        35                  40                  45              


Ile Tyr Asn Gln Lys Glu Gly His Phe Pro Arg Val Thr Thr Val Ser 
    50                  55                  60                  


Glu Ser Thr Lys Arg Glu Asn Met Asp Phe Ser Ile Ser Ile Ser Asn 
65                  70                  75                  80  


Ile Thr Pro Ala Asp Ala Gly Thr Tyr Tyr Cys Val Lys Phe Arg Lys 
                85                  90                  95      


Gly Ser Pro Asp Thr Glu Phe Lys Ser Gly Ala Gly Thr Glu Leu Ser 
            100                 105                 110         


Val Arg Ala Lys Pro Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
        115                 120                 125             


Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu 
    130                 135                 140                 


Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
145                 150                 155                 160 


Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
                165                 170                 175     


Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
            180                 185                 190         


Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro 
        195                 200                 205             


Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys 
    210                 215                 220                 


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro 
225                 230                 235                 240 


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                245                 250                 255     


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
            260                 265                 270         


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        275                 280                 285             


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
    290                 295                 300                 


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
305                 310                 315                 320 


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Gly Ala Pro Ile Glu Lys 
                325                 330                 335     


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
            340                 345                 350         


Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr 
        355                 360                 365             


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    370                 375                 380                 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
385                 390                 395                 400 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
                405                 410                 415     


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            420                 425                 430         


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445             


Lys 
    


<210>  34
<211>  705
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  34
gactccccag acagaccttg gaacccacct accttctccc cagcactgct cgtcgtgacc       60

gaaggagaca acgcaacctt cacctgtagc ttctccaaca catcggagag cttcgtgcta      120

aactggtatc gcatgagccc tagcaaccag actgacaagc tggcagcctt ccctgaggac      180

cgcagccagc caggacagga ctgccgcttc cgtgtcacac aactgcccaa cggacgtgac      240

ttccacatga gcgtggtcag agcaagacgc aatgacagcg gcacctacct ctgtggagct      300

atctccctgg ctcccaaggc acagatcaaa gagagcctga gggcagagct gagggtgaca      360

gagagaaggg cagaagtctc gagccgtacg gtggctgcac catctgtctt catcttcccg      420

ccatctgatg agcagttgaa atctggaact gcctctgttg tgtgcctgct gaataacttc      480

tatcccagag aggccaaagt acagtggaag gtggataacg ccctccaatc gggtaactcc      540

caggagagtg tcacagagca ggacagcaag gacagcacct acagcctcag cagcaccctg      600

acgctgagca aagcagacta cgagaaacac aaagtctacg cctgcgaagt cacccatcag      660

ggcctgagct cgcccgtcac aaagagcttc aacaggggag agtgt                      705


<210>  35
<211>  235
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  35

Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu 
1               5                   10                  15      


Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser 
            20                  25                  30          


Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr Arg Met Ser Pro Ser 
        35                  40                  45              


Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro 
    50                  55                  60                  


Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp 
65                  70                  75                  80  


Phe His Met Ser Val Val Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr 
                85                  90                  95      


Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Ala Gln Ile Lys Glu Ser 
            100                 105                 110         


Leu Arg Ala Glu Leu Arg Val Thr Glu Arg Arg Ala Glu Val Ser Ser 
        115                 120                 125             


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
    130                 135                 140                 


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
145                 150                 155                 160 


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
                165                 170                 175     


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
            180                 185                 190         


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
        195                 200                 205             


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
    210                 215                 220                 


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 235 


<210>  36
<211>  1350
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  36
gaggtgcagc tggtggagtc tggaggaggc ttggtccagc ctggggggtc cctgagactc       60

tcctgtgcag cctctgggtt caacatcaaa gacacctaca tccactgggt ccgccaggct      120

ccagggaagg agcgggagtg ggtcgcccgg atttatccca caaacggtta cacacggtac      180

gcagactccg tgaagggccg attcaccatc tccagagaca atgccaagga cactgtgtat      240

cttcaaatga acagcctgag agccgaggac acggccgtgt attactgttc ccggtgggga      300

ggggacgggt tctatgctat ggactactgg ggccaaggaa cactggtcac cgtctcgagc      360

gcgtcgacca agggcccatc ggtcttcccg ctagcaccct cctccaagag cacctctggg      420

ggcacagcgg ccctgggctg cctggtcaag gactacttcc ccgaacctgt gacggtgtcg      480

tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca      540

ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacccagacc      600

tacatctgca acgtgaatca caagcccagc aacaccaagg tggacaagaa agttgagccc      660

aaatcttgtg acaaaactca cacatgccca ccgtgcccag cacctgaact cctgggggga      720

ccgtcagtct tcctcttccc cccaaaaccc aaggacaccc tcatgatctc ccggacccct      780

gaggtcacat gcgtggtggt ggacgtgagc cacgaagacc ctgaggtcaa gttcaactgg      840

tacgtggacg gcgtggaggt gcataatgcc aagacaaagc cgcgggagga gcagtacaac      900

agcacgtacc gggtggtcag cgtcctcacc gtcctgcacc aggactggct gaatggcaag      960

gagtacaagt gcaaggtctc caacaaagcc ctcccagccc ccatcgagaa aaccatctcc     1020

aaagccaaag ggcagccccg agaaccacag gtgtacaccc tgcccccatc cagggatgag     1080

ctgaccaaga accaggtcag cctgacctgc ctggtcaaag gcttctatcc cagcgacatc     1140

gccgtggagt gggagagcaa tgggcagccg gagaacaact acaagaccac gcctcccgtg     1200

ctggactccg acggctcctt cttcctctac agcaagctca ccgtggacaa gagcaggtgg     1260

cagcagggga acgtcttctc atgctccgtg atgcatgagg ctctgcacaa ccactacacg     1320

cagaagagcc tctccctgtc tcccgggaaa                                      1350


<210>  37
<211>  450
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  37

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile Lys Asp Thr 
            20                  25                  30          


Tyr Ile His Trp Val Arg Gln Ala Pro Gly Lys Glu Arg Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Tyr Pro Thr Asn Gly Tyr Thr Arg Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asp Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ser Arg Trp Gly Gly Asp Gly Phe Tyr Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
225                 230                 235                 240 


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                245                 250                 255     


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
            260                 265                 270         


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        275                 280                 285             


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
    290                 295                 300                 


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
305                 310                 315                 320 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
                325                 330                 335     


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            340                 345                 350         


Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 
        355                 360                 365             


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    370                 375                 380                 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
385                 390                 395                 400 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
                405                 410                 415     


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
            420                 425                 430         


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
        435                 440                 445             


Gly Lys 
    450 


<210>  38
<211>  684
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  38
gaagaggaac tccaggtgat ccagcccgac aagtccgtga gcgtggctgc tggagagagc       60

gccatcctgc actgtaccgt gacctccctg atccctgtgg gacccatcca gtggttcaga      120

ggagctggac ctgcaagaga actgatctac aaccagaagg agggacactt ccctagagtg      180

accacagtga gcgagtccac caagcggaat aacatggact tctccatcag aatcggcaac      240

atcacccctg ctgacgcagg cacctactat tgcgtgaagt tcaggaaggg cagccctgac      300

gatgtcgagt tcaagtccgg cgctggaacc gagctgagcg tgagagccaa gccctcgagc      360

cgtacggtgg ctgcaccatc tgtcttcatc ttcccgccat ctgatgagca gttgaaatct      420

ggaactgcct ctgttgtgtg cctgctgaat aacttctatc ccagagaggc caaagtacag      480

tggaaggtgg ataacgccct ccaatcgggt aactcccagg agagtgtcac agagcaggac      540

agcaaggaca gcacctacag cctcagcagc accctgacgc tgagcaaagc agactacgag      600

aaacacaaag tctacgcctg cgaagtcacc catcagggcc tgagctcgcc cgtcacaaag      660

agcttcaaca ggggagagtg ttag                                             684


<210>  39
<211>  227
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  39

Glu Glu Glu Leu Gln Val Ile Gln Pro Asp Lys Ser Val Ser Val Ala 
1               5                   10                  15      


Ala Gly Glu Ser Ala Ile Leu His Cys Thr Val Thr Ser Leu Ile Pro 
            20                  25                  30          


Val Gly Pro Ile Gln Trp Phe Arg Gly Ala Gly Pro Ala Arg Glu Leu 
        35                  40                  45              


Ile Tyr Asn Gln Lys Glu Gly His Phe Pro Arg Val Thr Thr Val Ser 
    50                  55                  60                  


Glu Ser Thr Lys Arg Asn Asn Met Asp Phe Ser Ile Arg Ile Gly Asn 
65                  70                  75                  80  


Ile Thr Pro Ala Asp Ala Gly Thr Tyr Tyr Cys Val Lys Phe Arg Lys 
                85                  90                  95      


Gly Ser Pro Asp Asp Val Glu Phe Lys Ser Gly Ala Gly Thr Glu Leu 
            100                 105                 110         


Ser Val Arg Ala Lys Pro Ser Ser Arg Thr Val Ala Ala Pro Ser Val 
        115                 120                 125             


Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser 
    130                 135                 140                 


Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln 
145                 150                 155                 160 


Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val 
                165                 170                 175     


Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu 
            180                 185                 190         


Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu 
        195                 200                 205             


Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg 
    210                 215                 220                 


Gly Glu Cys 
225         


<210>  40
<211>  1359
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  40
caggtgcagc tggtgcagtc tgggggagga ttggtgcagg ctgggggctc tctgagactc       60

tcctgtgcag cctctggacg caccttcagt agttatgcca tggcctggtt ccgccaggct      120

ccagggaagg agcgtgagtt tgtagcagct attagctgga gtggtgcaaa catatacgtt      180

gcagactccg tgaagggccg attcaccatc tccagagaca acgccaagga cacggtgtat      240

ctgcaaatga acagcctgaa acctgaggac acggccgttt attactgtgc agtaaagctc      300

ggtttcgcac ctgtagaaga aaggcagtat gactactggg gccaggggac ccaggtcacc      360

gtctcgagcg cgtcgaccaa gggcccatcg gtcttcccgc tagcaccctc ctccaagagc      420

acctctgggg gcacagcggc cctgggctgc ctggtcaagg actacttccc cgaacctgtg      480

acggtgtcgt ggaactcagg cgccctgacc agcggcgtgc acaccttccc ggctgtccta      540

cagtcctcag gactctactc cctcagcagc gtggtgaccg tgccctccag cagcttgggc      600

acccagacct acatctgcaa cgtgaatcac aagcccagca acaccaaggt ggacaagaaa      660

gttgagccca aatcttgtga caaaactcac acatgcccac cgtgcccagc acctgaactc      720

ctggggggac cgtcagtctt cctcttcccc ccaaaaccca aggacaccct catgatctcc      780

cggacccctg aggtcacatg cgtggtggtg gacgtgagcc acgaagaccc tgaggtcaag      840

ttcaactggt acgtggacgg cgtggaggtg cataatgcca agacaaagcc gcgggaggag      900

cagtacaaca gcacgtaccg ggtggtcagc gtcctcaccg tcctgcacca ggactggctg      960

aatggcaagg agtacaagtg caaggtctcc aacaaagccc tcccagcccc catcgagaaa     1020

accatctcca aagccaaagg gcagccccga gaaccacagg tgtacaccct gcccccatcc     1080

agggatgagc tgaccaagaa ccaggtcagc ctgacctgcc tggtcaaagg cttctatccc     1140

agcgacatcg ccgtggagtg ggagagcaat gggcagccgg agaacaacta caagaccacg     1200

cctcccgtgc tggactccga cggctccttc ttcctctaca gcaagctcac cgtggacaag     1260

agcaggtggc agcaggggaa cgtcttctca tgctccgtga tgcatgaggc tctgcacaac     1320

cactacacgc agaagagcct ctccctgtct cccgggaaa                            1359


<210>  41
<211>  453
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  41

Gln Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ala Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Ser Trp Ser Gly Ala Asn Ile Tyr Val Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asp Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Val Lys Leu Gly Phe Ala Pro Val Glu Glu Arg Gln Tyr Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Ala Ser Thr Lys Gly 
        115                 120                 125             


Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly 
    130                 135                 140                 


Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val 
145                 150                 155                 160 


Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe 
                165                 170                 175     


Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val 
            180                 185                 190         


Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val 
        195                 200                 205             


Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys 
    210                 215                 220                 


Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu 
225                 230                 235                 240 


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
                245                 250                 255     


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
            260                 265                 270         


Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
        275                 280                 285             


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 
    290                 295                 300                 


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
305                 310                 315                 320 


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 
                325                 330                 335     


Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
            340                 345                 350         


Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln 
        355                 360                 365             


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
    370                 375                 380                 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
385                 390                 395                 400 


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 
                405                 410                 415     


Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
            420                 425                 430         


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
        435                 440                 445             


Leu Ser Pro Gly Lys 
    450             


<210>  42
<211>  678
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  42
gaagaggaac tccaggtgat ccagcccgac aagtccgtga gcgtggctgc tggagagagc       60

gccatcctgc actgtaccgt gacctccctg atccctgtgg gacccatcca gtggttcaga      120

ggagctggac ctgcaagaga actgatctac aaccagaagg agggacactt ccctagagtg      180

accacagtga gcgagtccac caagcgggag aacatggact tctccatcag catctccaac      240

atcacccctg ctgacgcagg cacctactat tgcgtgaagt tcaggaaggg cagccctgac      300

accgagttca agtccggcgc tggaaccgag ctgagcgtga gagccaagcc ctcgagccgt      360

acggtggctg caccatctgt cttcatcttc ccgccatctg atgagcagtt gaaatctgga      420

actgcctctg ttgtgtgcct gctgaataac ttctatccca gagaggccaa agtacagtgg      480

aaggtggata acgccctcca atcgggtaac tcccaggaga gtgtcacaga gcaggacagc      540

aaggacagca cctacagcct cagcagcacc ctgacgctga gcaaagcaga ctacgagaaa      600

cacaaagtct acgcctgcga agtcacccat cagggcctga gctcgcccgt cacaaagagc      660

ttcaacaggg gagagtgt                                                    678


<210>  43
<211>  226
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  43

Glu Glu Glu Leu Gln Val Ile Gln Pro Asp Lys Ser Val Ser Val Ala 
1               5                   10                  15      


Ala Gly Glu Ser Ala Ile Leu His Cys Thr Val Thr Ser Leu Ile Pro 
            20                  25                  30          


Val Gly Pro Ile Gln Trp Phe Arg Gly Ala Gly Pro Ala Arg Glu Leu 
        35                  40                  45              


Ile Tyr Asn Gln Lys Glu Gly His Phe Pro Arg Val Thr Thr Val Ser 
    50                  55                  60                  


Glu Ser Thr Lys Arg Glu Asn Met Asp Phe Ser Ile Ser Ile Ser Asn 
65                  70                  75                  80  


Ile Thr Pro Ala Asp Ala Gly Thr Tyr Tyr Cys Val Lys Phe Arg Lys 
                85                  90                  95      


Gly Ser Pro Asp Thr Glu Phe Lys Ser Gly Ala Gly Thr Glu Leu Ser 
            100                 105                 110         


Val Arg Ala Lys Pro Ser Ser Arg Thr Val Ala Ala Pro Ser Val Phe 
        115                 120                 125             


Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val 
    130                 135                 140                 


Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp 
145                 150                 155                 160 


Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr 
                165                 170                 175     


Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr 
            180                 185                 190         


Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val 
        195                 200                 205             


Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly 
    210                 215                 220                 


Glu Cys 
225     


<210>  44
<211>  1098
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  44
gactccccag acaggccctg gaaccccccc accttctccc cagccctgct cgtggtgacc       60

gaaggggaca acgccacctt cacctgtagc ttctccaaca catcggagag cttcgtgcta      120

aactggtatc gcatgagccc cagcaaccag acggacaagc tggccgcctt ccccgaggac      180

cgcagccagc ccggccagga ctgccgcttc cgtgtcacac aactgcccaa cgggcgtgac      240

ttccacatga gcgtggtcag agcccggcgc aatgacagcg gcacctacct ctgtggagct      300

atctcccggg cccccaaggc gcagatcaaa gagagcctgc gggcagagct gagggtgaca      360

gagagaaggg cagaagtctc gagccgtacg gtggctgcac catctgtctt catcttcccg      420

ccatctgatg agcagttgaa atctggaact gcctctgttg tgtgcctgct gaataacttc      480

tatcccagag aggccaaagt acagtggaag gtggataacg ccctccaatc gggtaactcc      540

caggagagtg tcacagagca ggacagcaag gacagcacct acagcctcag cagcaccctg      600

acgctgagca aagcagacta cgagaaacac aaagtctacg cctgcgaagt cacccatcag      660

ggcctgagct cgcccgtcac aaagagcttc aacaggggag agtgtaccgt cctaggtcag      720

cccaaggcgg ccgctgaggt gcagctggtg gagtctgggg gaggcttggt acagcctggg      780

gggtccctga gactctcctg tgcagcctct ggattcacct ttgacgacta tggcatgagc      840

tgggtccgcc aggctccagg gaagtggctg gagtgggtct cagatattag ctggaatggt      900

ggtagcacat actacgcaga ctccgtgaag ggccggttca ccatctccag agacaatgcc      960

gagaacacgc tgtatctgca aatgaacagc ctgaaacctg acgacacggc cgtgtattac     1020

tgtgcgaaaa tgggtgaagg gggatggggt gcaaatgact actggggcca ggggacccag     1080

gtcaccgtgt cctcataa                                                   1098


<210>  45
<211>  365
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  45

Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu 
1               5                   10                  15      


Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser 
            20                  25                  30          


Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr Arg Met Ser Pro Ser 
        35                  40                  45              


Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro 
    50                  55                  60                  


Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp 
65                  70                  75                  80  


Phe His Met Ser Val Val Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr 
                85                  90                  95      


Leu Cys Gly Ala Ile Ser Arg Ala Pro Lys Ala Gln Ile Lys Glu Ser 
            100                 105                 110         


Leu Arg Ala Glu Leu Arg Val Thr Glu Arg Arg Ala Glu Val Ser Ser 
        115                 120                 125             


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
    130                 135                 140                 


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
145                 150                 155                 160 


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
                165                 170                 175     


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
            180                 185                 190         


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
        195                 200                 205             


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
    210                 215                 220                 


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys Thr Val Leu Gly Gln 
225                 230                 235                 240 


Pro Lys Ala Ala Ala Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
                245                 250                 255     


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
            260                 265                 270         


Thr Phe Asp Asp Tyr Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys 
        275                 280                 285             


Trp Leu Glu Trp Val Ser Asp Ile Ser Trp Asn Gly Gly Ser Thr Tyr 
    290                 295                 300                 


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala 
305                 310                 315                 320 


Glu Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Lys Pro Asp Asp Thr 
                325                 330                 335     


Ala Val Tyr Tyr Cys Ala Lys Met Gly Glu Gly Gly Trp Gly Ala Asn 
            340                 345                 350         


Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        355                 360                 365 


<210>  46
<211>  1095
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  46
gactccccag acaggccctg gaaccccccc accttctccc cagccctgct cgtggtgacc       60

gaaggggaca acgccacctt cacctgtagc ttctccaaca catcggagag cttcgtgcta      120

aactggtatc gcatgagccc cagcaaccag acggacaagc tggccgcctt ccccgaggac      180

cgcagccagc ccggccagga ctgccgcttc cgtgtcacac aactgcccaa cgggcgtgac      240

ttccacatga gcgtggtcag agcccggcgc aatgacagcg gcacctacct ctgtggagct      300

atctcccggg cccccaaggc gcagatcaaa gagagcctgc gggcagagct gagggtgaca      360

gagagaaggg cagaagtctc gagccgtacg gtggctgcac catctgtctt catcttcccg      420

ccatctgatg agcagttgaa atctggaact gcctctgttg tgtgcctgct gaataacttc      480

tatcccagag aggccaaagt acagtggaag gtggataacg ccctccaatc gggtaactcc      540

caggagagtg tcacagagca ggacagcaag gacagcacct acagcctcag cagcaccctg      600

acgctgagca aagcagacta cgagaaacac aaagtctacg cctgcgaagt cacccatcag      660

ggcctgagct cgcccgtcac aaagagcttc aacaggggag agtgtaccgt cctaggtcag      720

cccaaggcgg ccgctgaggt gcagctggtg gagtctgggg gaggcttagt gcagcctggg      780

gagtctctga cactctcctg tgtagttgct ggaagcatct tcagcttcgc catgagctgg      840

tatcgccagg ctccaggaaa agagcgcgaa ttggtcgcac gtattggttc ggatgatcgg      900

gtaacctacg cagattccgt gaagggccga tttaccatct ccagagacaa catcaagcgc      960

acggcgggcc tgcagatgaa cagcctgaaa cctgaggaca cggccgtcta ctactgcaat     1020

gcccaaacag atttgaggga ttggactgtg cgagagtact ggggccaggg gacccaggtc     1080

accgtctcct cataa                                                      1095


<210>  47
<211>  364
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  47

Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu 
1               5                   10                  15      


Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser 
            20                  25                  30          


Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr Arg Met Ser Pro Ser 
        35                  40                  45              


Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro 
    50                  55                  60                  


Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp 
65                  70                  75                  80  


Phe His Met Ser Val Val Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr 
                85                  90                  95      


Leu Cys Gly Ala Ile Ser Arg Ala Pro Lys Ala Gln Ile Lys Glu Ser 
            100                 105                 110         


Leu Arg Ala Glu Leu Arg Val Thr Glu Arg Arg Ala Glu Val Ser Ser 
        115                 120                 125             


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
    130                 135                 140                 


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
145                 150                 155                 160 


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
                165                 170                 175     


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
            180                 185                 190         


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
        195                 200                 205             


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
    210                 215                 220                 


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys Thr Val Leu Gly Gln 
225                 230                 235                 240 


Pro Lys Ala Ala Ala Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
                245                 250                 255     


Val Gln Pro Gly Glu Ser Leu Thr Leu Ser Cys Val Val Ala Gly Ser 
            260                 265                 270         


Ile Phe Ser Phe Ala Met Ser Trp Tyr Arg Gln Ala Pro Gly Lys Glu 
        275                 280                 285             


Arg Glu Leu Val Ala Arg Ile Gly Ser Asp Asp Arg Val Thr Tyr Ala 
    290                 295                 300                 


Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ile Lys Arg 
305                 310                 315                 320 


Thr Ala Gly Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val 
                325                 330                 335     


Tyr Tyr Cys Asn Ala Gln Thr Asp Leu Arg Asp Trp Thr Val Arg Glu 
            340                 345                 350         


Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        355                 360                 


<210>  48
<211>  1095
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  48
gactccccag acagaccttg gaacccacct accttctccc cagcactgct cgtcgtgacc       60

gaaggagaca acgcaacctt cacctgtagc ttctccaaca catcggagag cttcgtgcta      120

aactggtatc gcatgagccc tagcaaccag actgacaagc tggcagcctt ccctgaggac      180

cgcagccagc caggacagga ctgccgcttc cgtgtcacac aactgcccaa cggacgtgac      240

ttccacatga gcgtggtcag agcaagacgc aatgacagcg gcacctacct ctgtggagct      300

atctccctgg ctcccaaggc acagatcaaa gagagcctga gggcagagct gagggtgaca      360

gagagaaggg cagaagtctc gagccgtacg gtggctgcac catctgtctt catcttcccg      420

ccatctgatg agcagttgaa atctggaact gcctctgttg tgtgcctgct gaataacttc      480

tatcccagag aggccaaagt acagtggaag gtggataacg ccctccaatc gggtaactcc      540

caggagagtg tcacagagca ggacagcaag gacagcacct acagcctcag cagcaccctg      600

acgctgagca aagcagacta cgagaaacac aaagtctacg cctgcgaagt cacccatcag      660

ggcctgagct cgcccgtcac aaagagcttc aacaggggag agtgtaccgt cctaggtcag      720

cccaaggcgg ccgctgaggt gcagctggtg gagtctgggg gaggcttggt acagcctggg      780

gggtccctga gactctcctg tgcagcctct ggattcacct ttgacgacta tggcatgagc      840

tgggtccgcc aggctccagg gaagtggctg gagtgggtct cagatattag ctggaatggt      900

ggtagcacat actacgcaga ctccgtgaag ggccggttca ccatctccag agacaatgcc      960

gagaacacgc tgtatctgca aatgaacagc ctgaaacctg acgacacggc cgtgtattac     1020

tgtgcgaaaa tgggtgaagg gggatggggt gcaaatgact actggggcca ggggacccag     1080

gtcaccgtgt cctca                                                      1095


<210>  49
<211>  365
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  49

Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu 
1               5                   10                  15      


Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser 
            20                  25                  30          


Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr Arg Met Ser Pro Ser 
        35                  40                  45              


Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro 
    50                  55                  60                  


Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp 
65                  70                  75                  80  


Phe His Met Ser Val Val Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr 
                85                  90                  95      


Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Ala Gln Ile Lys Glu Ser 
            100                 105                 110         


Leu Arg Ala Glu Leu Arg Val Thr Glu Arg Arg Ala Glu Val Ser Ser 
        115                 120                 125             


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
    130                 135                 140                 


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
145                 150                 155                 160 


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
                165                 170                 175     


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
            180                 185                 190         


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
        195                 200                 205             


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
    210                 215                 220                 


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys Thr Val Leu Gly Gln 
225                 230                 235                 240 


Pro Lys Ala Ala Ala Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
                245                 250                 255     


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
            260                 265                 270         


Thr Phe Asp Asp Tyr Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys 
        275                 280                 285             


Trp Leu Glu Trp Val Ser Asp Ile Ser Trp Asn Gly Gly Ser Thr Tyr 
    290                 295                 300                 


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala 
305                 310                 315                 320 


Glu Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Lys Pro Asp Asp Thr 
                325                 330                 335     


Ala Val Tyr Tyr Cys Ala Lys Met Gly Glu Gly Gly Trp Gly Ala Asn 
            340                 345                 350         


Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        355                 360                 365 


<210>  50
<211>  1092
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  50
gactccccag acagaccttg gaacccacct accttctccc cagcactgct cgtcgtgacc       60

gaaggagaca acgcaacctt cacctgtagc ttctccaaca catcggagag cttcgtgcta      120

aactggtatc gcatgagccc tagcaaccag actgacaagc tggcagcctt ccctgaggac      180

cgcagccagc caggacagga ctgccgcttc cgtgtcacac aactgcccaa cggacgtgac      240

ttccacatga gcgtggtcag agcaagacgc aatgacagcg gcacctacct ctgtggagct      300

atctccctgg ctcccaaggc acagatcaaa gagagcctga gggcagagct gagggtgaca      360

gagagaaggg cagaagtctc gagccgtacg gtggctgcac catctgtctt catcttcccg      420

ccatctgatg agcagttgaa atctggaact gcctctgttg tgtgcctgct gaataacttc      480

tatcccagag aggccaaagt acagtggaag gtggataacg ccctccaatc gggtaactcc      540

caggagagtg tcacagagca ggacagcaag gacagcacct acagcctcag cagcaccctg      600

acgctgagca aagcagacta cgagaaacac aaagtctacg cctgcgaagt cacccatcag      660

ggcctgagct cgcccgtcac aaagagcttc aacaggggag agtgtaccgt cctaggtcag      720

cccaaggcgg ccgctgaggt gcagctggtg gagtctgggg gaggcttagt gcagcctggg      780

gagtctctga cactctcctg tgtagttgct ggaagcatct tcagcttcgc catgagctgg      840

tatcgccagg ctccaggaaa agagcgcgaa ttggtcgcac gtattggttc ggatgatcgg      900

gtaacctacg cagattccgt gaagggccga tttaccatct ccagagacaa catcaagcgc      960

acggcgggcc tgcagatgaa cagcctgaaa cctgaggaca cggccgtcta ctactgcaat     1020

gcccaaacag atttgaggga ttggactgtg cgagagtact ggggccaggg gacccaggtc     1080

accgtctcct ca                                                         1092


<210>  51
<211>  364
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  51

Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu 
1               5                   10                  15      


Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser 
            20                  25                  30          


Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr Arg Met Ser Pro Ser 
        35                  40                  45              


Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro 
    50                  55                  60                  


Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp 
65                  70                  75                  80  


Phe His Met Ser Val Val Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr 
                85                  90                  95      


Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Ala Gln Ile Lys Glu Ser 
            100                 105                 110         


Leu Arg Ala Glu Leu Arg Val Thr Glu Arg Arg Ala Glu Val Ser Ser 
        115                 120                 125             


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
    130                 135                 140                 


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
145                 150                 155                 160 


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
                165                 170                 175     


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
            180                 185                 190         


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
        195                 200                 205             


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
    210                 215                 220                 


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys Thr Val Leu Gly Gln 
225                 230                 235                 240 


Pro Lys Ala Ala Ala Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
                245                 250                 255     


Val Gln Pro Gly Glu Ser Leu Thr Leu Ser Cys Val Val Ala Gly Ser 
            260                 265                 270         


Ile Phe Ser Phe Ala Met Ser Trp Tyr Arg Gln Ala Pro Gly Lys Glu 
        275                 280                 285             


Arg Glu Leu Val Ala Arg Ile Gly Ser Asp Asp Arg Val Thr Tyr Ala 
    290                 295                 300                 


Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ile Lys Arg 
305                 310                 315                 320 


Thr Ala Gly Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val 
                325                 330                 335     


Tyr Tyr Cys Asn Ala Gln Thr Asp Leu Arg Asp Trp Thr Val Arg Glu 
            340                 345                 350         


Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        355                 360                 


<210>  52
<211>  1077
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  52
gaagaggaac tccaggtgat ccagcccgac aagtccgtga gcgtggctgc tggagagagc       60

gccatcctgc actgtaccgt gacctccctg atccctgtgg gacccatcca gtggttcaga      120

ggagctggac ctgcaagaga actgatctac aaccagaagg agggacactt ccctagagtg      180

accacagtga gcgagtccac caagcggaat aacatggact tctccatcag aatcggcaac      240

atcacccctg ctgacgcagg cacctactat tgcgtgaagt tcaggaaggg cagccctgac      300

gatgtcgagt tcaagtccgg cgctggaacc gagctgagcg tgagagccaa gccctcgagc      360

tcgagccgta cggtggctgc accatctgtc ttcatcttcc cgccatctga tgagcagttg      420

aaatctggaa ctgcctctgt tgtgtgcctg ctgaataact tctatcccag agaggccaaa      480

gtacagtgga aggtggataa cgccctccaa tcgggtaact cccaggagag tgtcacagag      540

caggacagca aggacagcac ctacagcctc agcagcaccc tgacgctgag caaagcagac      600

tacgagaaac acaaagtcta cgcctgcgaa gtcacccatc agggcctgag ctcgcccgtc      660

acaaagagct tcaacagggg agagtgtacc gtcctaggtc agcccaaggc ggccgctgag      720

gtgcagctgg tggagtctgg gggaggcttg gtacagcctg gggggtccct gagactctcc      780

tgtgcagcct ctggattcac ctttgacgac tatggcatga gctgggtccg ccaggctcca      840

gggaagtggc tggagtgggt ctcagatatt agctggaatg gtggtagcac atactacgca      900

gactccgtga agggccggtt caccatctcc agagacaatg ccgagaacac gctgtatctg      960

caaatgaaca gcctgaaacc tgacgacacg gccgtgtatt actgtgcgaa aatgggtgaa     1020

gggggatggg gtgcaaatga ctactggggc caggggaccc aggtcaccgt gtcctca        1077


<210>  53
<211>  359
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  53

Glu Glu Glu Leu Gln Val Ile Gln Pro Asp Lys Ser Val Ser Val Ala 
1               5                   10                  15      


Ala Gly Glu Ser Ala Ile Leu His Cys Thr Val Thr Ser Leu Ile Pro 
            20                  25                  30          


Val Gly Pro Ile Gln Trp Phe Arg Gly Ala Gly Pro Ala Arg Glu Leu 
        35                  40                  45              


Ile Tyr Asn Gln Lys Glu Gly His Phe Pro Arg Val Thr Thr Val Ser 
    50                  55                  60                  


Glu Ser Thr Lys Arg Asn Asn Met Asp Phe Ser Ile Arg Ile Gly Asn 
65                  70                  75                  80  


Ile Thr Pro Ala Asp Ala Gly Thr Tyr Tyr Cys Val Lys Phe Arg Lys 
                85                  90                  95      


Gly Ser Pro Asp Asp Val Glu Phe Lys Ser Gly Ala Gly Thr Glu Leu 
            100                 105                 110         


Ser Val Arg Ala Lys Pro Ser Ser Ser Ser Arg Thr Val Ala Ala Pro 
        115                 120                 125             


Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr 
    130                 135                 140                 


Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys 
145                 150                 155                 160 


Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu 
                165                 170                 175     


Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser 
            180                 185                 190         


Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala 
        195                 200                 205             


Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe 
    210                 215                 220                 


Asn Arg Gly Glu Cys Thr Val Leu Gly Gln Pro Lys Ala Ala Ala Glu 
225                 230                 235                 240 


Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser 
                245                 250                 255     


Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr Gly 
            260                 265                 270         


Met Ser Trp Val Arg Gln Ala Pro Gly Lys Trp Leu Glu Trp Val Ser 
        275                 280                 285             


Asp Ile Ser Trp Asn Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys 
    290                 295                 300                 


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Glu Asn Thr Leu Tyr Leu 
305                 310                 315                 320 


Gln Met Asn Ser Leu Lys Pro Asp Asp Thr Ala Val Tyr Tyr Cys Ala 
                325                 330                 335     


Lys Met Gly Glu Gly Gly Trp Gly Ala Asn Asp Tyr Trp Gly Gln Gly 
            340                 345                 350         


Thr Gln Val Thr Val Ser Ser 
        355                 


<210>  54
<211>  1074
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  54
gaagaggaac tccaggtgat ccagcccgac aagtccgtga gcgtggctgc tggagagagc       60

gccatcctgc actgtaccgt gacctccctg atccctgtgg gacccatcca gtggttcaga      120

ggagctggac ctgcaagaga actgatctac aaccagaagg agggacactt ccctagagtg      180

accacagtga gcgagtccac caagcggaat aacatggact tctccatcag aatcggcaac      240

atcacccctg ctgacgcagg cacctactat tgcgtgaagt tcaggaaggg cagccctgac      300

gatgtcgagt tcaagtccgg cgctggaacc gagctgagcg tgagagccaa gccctcgagc      360

tcgagccgta cggtggctgc accatctgtc ttcatcttcc cgccatctga tgagcagttg      420

aaatctggaa ctgcctctgt tgtgtgcctg ctgaataact tctatcccag agaggccaaa      480

gtacagtgga aggtggataa cgccctccaa tcgggtaact cccaggagag tgtcacagag      540

caggacagca aggacagcac ctacagcctc agcagcaccc tgacgctgag caaagcagac      600

tacgagaaac acaaagtcta cgcctgcgaa gtcacccatc agggcctgag ctcgcccgtc      660

acaaagagct tcaacagggg agagtgtacc gtcctaggtc agcccaaggc ggccgctgag      720

gtgcagctgg tggagtctgg gggaggctta gtgcagcctg gggagtctct gacactctcc      780

tgtgtagttg ctggaagcat cttcagcttc gccatgagct ggtatcgcca ggctccagga      840

aaagagcgcg aattggtcgc acgtattggt tcggatgatc gggtaaccta cgcagattcc      900

gtgaagggcc gatttaccat ctccagagac aacatcaagc gcacggcggg cctgcagatg      960

aacagcctga aacctgagga cacggccgtc tactactgca atgcccaaac agatttgagg     1020

gattggactg tgcgagagta ctggggccag gggacccagg tcaccgtctc ctca           1074


<210>  55
<211>  358
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  55

Glu Glu Glu Leu Gln Val Ile Gln Pro Asp Lys Ser Val Ser Val Ala 
1               5                   10                  15      


Ala Gly Glu Ser Ala Ile Leu His Cys Thr Val Thr Ser Leu Ile Pro 
            20                  25                  30          


Val Gly Pro Ile Gln Trp Phe Arg Gly Ala Gly Pro Ala Arg Glu Leu 
        35                  40                  45              


Ile Tyr Asn Gln Lys Glu Gly His Phe Pro Arg Val Thr Thr Val Ser 
    50                  55                  60                  


Glu Ser Thr Lys Arg Asn Asn Met Asp Phe Ser Ile Arg Ile Gly Asn 
65                  70                  75                  80  


Ile Thr Pro Ala Asp Ala Gly Thr Tyr Tyr Cys Val Lys Phe Arg Lys 
                85                  90                  95      


Gly Ser Pro Asp Asp Val Glu Phe Lys Ser Gly Ala Gly Thr Glu Leu 
            100                 105                 110         


Ser Val Arg Ala Lys Pro Ser Ser Ser Ser Arg Thr Val Ala Ala Pro 
        115                 120                 125             


Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr 
    130                 135                 140                 


Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys 
145                 150                 155                 160 


Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu 
                165                 170                 175     


Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser 
            180                 185                 190         


Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala 
        195                 200                 205             


Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe 
    210                 215                 220                 


Asn Arg Gly Glu Cys Thr Val Leu Gly Gln Pro Lys Ala Ala Ala Glu 
225                 230                 235                 240 


Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Glu Ser 
                245                 250                 255     


Leu Thr Leu Ser Cys Val Val Ala Gly Ser Ile Phe Ser Phe Ala Met 
            260                 265                 270         


Ser Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Leu Val Ala Arg 
        275                 280                 285             


Ile Gly Ser Asp Asp Arg Val Thr Tyr Ala Asp Ser Val Lys Gly Arg 
    290                 295                 300                 


Phe Thr Ile Ser Arg Asp Asn Ile Lys Arg Thr Ala Gly Leu Gln Met 
305                 310                 315                 320 


Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Asn Ala Gln 
                325                 330                 335     


Thr Asp Leu Arg Asp Trp Thr Val Arg Glu Tyr Trp Gly Gln Gly Thr 
            340                 345                 350         


Gln Val Thr Val Ser Ser 
        355             


<210>  56
<211>  1074
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  56
gaagaggaac tccaggtgat ccagcccgac aagtccgtga gcgtggctgc tggagagagc       60

gccatcctgc actgtaccgt gacctccctg atccctgtgg gacccatcca gtggttcaga      120

ggagctggac ctgcaagaga actgatctac aaccagaagg agggacactt ccctagagtg      180

accacagtga gcgagtccac caagcgggag aacatggact tctccatcag catctccaac      240

atcacccctg ctgacgcagg cacctactat tgcgtgaagt tcaggaaggg cagccctgac      300

accgagttca agtccggcgc tggaaccgag ctgagcgtga gagccaagcc ctcgagctcg      360

agccgtacgg tggctgcacc atctgtcttc atcttcccgc catctgatga gcagttgaaa      420

tctggaactg cctctgttgt gtgcctgctg aataacttct atcccagaga ggccaaagta      480

cagtggaagg tggataacgc cctccaatcg ggtaactccc aggagagtgt cacagagcag      540

gacagcaagg acagcaccta cagcctcagc agcaccctga cgctgagcaa agcagactac      600

gagaaacaca aagtctacgc ctgcgaagtc acccatcagg gcctgagctc gcccgtcaca      660

aagagcttca acaggggaga gtgtaccgtc ctaggtcagc ccaaggcggc cgctgaggtg      720

cagctggtgg agtctggggg aggcttggta cagcctgggg ggtccctgag actctcctgt      780

gcagcctctg gattcacctt tgacgactat ggcatgagct gggtccgcca ggctccaggg      840

aagtggctgg agtgggtctc agatattagc tggaatggtg gtagcacata ctacgcagac      900

tccgtgaagg gccggttcac catctccaga gacaatgccg agaacacgct gtatctgcaa      960

atgaacagcc tgaaacctga cgacacggcc gtgtattact gtgcgaaaat gggtgaaggg     1020

ggatggggtg caaatgacta ctggggccag gggacccagg tcaccgtgtc ctca           1074


<210>  57
<211>  358
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  57

Glu Glu Glu Leu Gln Val Ile Gln Pro Asp Lys Ser Val Ser Val Ala 
1               5                   10                  15      


Ala Gly Glu Ser Ala Ile Leu His Cys Thr Val Thr Ser Leu Ile Pro 
            20                  25                  30          


Val Gly Pro Ile Gln Trp Phe Arg Gly Ala Gly Pro Ala Arg Glu Leu 
        35                  40                  45              


Ile Tyr Asn Gln Lys Glu Gly His Phe Pro Arg Val Thr Thr Val Ser 
    50                  55                  60                  


Glu Ser Thr Lys Arg Glu Asn Met Asp Phe Ser Ile Ser Ile Ser Asn 
65                  70                  75                  80  


Ile Thr Pro Ala Asp Ala Gly Thr Tyr Tyr Cys Val Lys Phe Arg Lys 
                85                  90                  95      


Gly Ser Pro Asp Thr Glu Phe Lys Ser Gly Ala Gly Thr Glu Leu Ser 
            100                 105                 110         


Val Arg Ala Lys Pro Ser Ser Ser Ser Arg Thr Val Ala Ala Pro Ser 
        115                 120                 125             


Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala 
    130                 135                 140                 


Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val 
145                 150                 155                 160 


Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser 
                165                 170                 175     


Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr 
            180                 185                 190         


Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys 
        195                 200                 205             


Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn 
    210                 215                 220                 


Arg Gly Glu Cys Thr Val Leu Gly Gln Pro Lys Ala Ala Ala Glu Val 
225                 230                 235                 240 


Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu 
                245                 250                 255     


Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr Gly Met 
            260                 265                 270         


Ser Trp Val Arg Gln Ala Pro Gly Lys Trp Leu Glu Trp Val Ser Asp 
        275                 280                 285             


Ile Ser Trp Asn Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys Gly 
    290                 295                 300                 


Arg Phe Thr Ile Ser Arg Asp Asn Ala Glu Asn Thr Leu Tyr Leu Gln 
305                 310                 315                 320 


Met Asn Ser Leu Lys Pro Asp Asp Thr Ala Val Tyr Tyr Cys Ala Lys 
                325                 330                 335     


Met Gly Glu Gly Gly Trp Gly Ala Asn Asp Tyr Trp Gly Gln Gly Thr 
            340                 345                 350         


Gln Val Thr Val Ser Ser 
        355             


<210>  58
<211>  1071
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  58
gaagaggaac tccaggtgat ccagcccgac aagtccgtga gcgtggctgc tggagagagc       60

gccatcctgc actgtaccgt gacctccctg atccctgtgg gacccatcca gtggttcaga      120

ggagctggac ctgcaagaga actgatctac aaccagaagg agggacactt ccctagagtg      180

accacagtga gcgagtccac caagcgggag aacatggact tctccatcag catctccaac      240

atcacccctg ctgacgcagg cacctactat tgcgtgaagt tcaggaaggg cagccctgac      300

accgagttca agtccggcgc tggaaccgag ctgagcgtga gagccaagcc ctcgagctcg      360

agccgtacgg tggctgcacc atctgtcttc atcttcccgc catctgatga gcagttgaaa      420

tctggaactg cctctgttgt gtgcctgctg aataacttct atcccagaga ggccaaagta      480

cagtggaagg tggataacgc cctccaatcg ggtaactccc aggagagtgt cacagagcag      540

gacagcaagg acagcaccta cagcctcagc agcaccctga cgctgagcaa agcagactac      600

gagaaacaca aagtctacgc ctgcgaagtc acccatcagg gcctgagctc gcccgtcaca      660

aagagcttca acaggggaga gtgtaccgtc ctaggtcagc ccaaggcggc cgctgaggtg      720

cagctggtgg agtctggggg aggcttagtg cagcctgggg agtctctgac actctcctgt      780

gtagttgctg gaagcatctt cagcttcgcc atgagctggt atcgccaggc tccaggaaaa      840

gagcgcgaat tggtcgcacg tattggttcg gatgatcggg taacctacgc agattccgtg      900

aagggccgat ttaccatctc cagagacaac atcaagcgca cggcgggcct gcagatgaac      960

agcctgaaac ctgaggacac ggccgtctac tactgcaatg cccaaacaga tttgagggat     1020

tggactgtgc gagagtactg gggccagggg acccaggtca ccgtctcctc a              1071


<210>  59
<211>  357
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  59

Glu Glu Glu Leu Gln Val Ile Gln Pro Asp Lys Ser Val Ser Val Ala 
1               5                   10                  15      


Ala Gly Glu Ser Ala Ile Leu His Cys Thr Val Thr Ser Leu Ile Pro 
            20                  25                  30          


Val Gly Pro Ile Gln Trp Phe Arg Gly Ala Gly Pro Ala Arg Glu Leu 
        35                  40                  45              


Ile Tyr Asn Gln Lys Glu Gly His Phe Pro Arg Val Thr Thr Val Ser 
    50                  55                  60                  


Glu Ser Thr Lys Arg Glu Asn Met Asp Phe Ser Ile Ser Ile Ser Asn 
65                  70                  75                  80  


Ile Thr Pro Ala Asp Ala Gly Thr Tyr Tyr Cys Val Lys Phe Arg Lys 
                85                  90                  95      


Gly Ser Pro Asp Thr Glu Phe Lys Ser Gly Ala Gly Thr Glu Leu Ser 
            100                 105                 110         


Val Arg Ala Lys Pro Ser Ser Ser Ser Arg Thr Val Ala Ala Pro Ser 
        115                 120                 125             


Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala 
    130                 135                 140                 


Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val 
145                 150                 155                 160 


Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser 
                165                 170                 175     


Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr 
            180                 185                 190         


Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys 
        195                 200                 205             


Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn 
    210                 215                 220                 


Arg Gly Glu Cys Thr Val Leu Gly Gln Pro Lys Ala Ala Ala Glu Val 
225                 230                 235                 240 


Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Glu Ser Leu 
                245                 250                 255     


Thr Leu Ser Cys Val Val Ala Gly Ser Ile Phe Ser Phe Ala Met Ser 
            260                 265                 270         


Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Leu Val Ala Arg Ile 
        275                 280                 285             


Gly Ser Asp Asp Arg Val Thr Tyr Ala Asp Ser Val Lys Gly Arg Phe 
    290                 295                 300                 


Thr Ile Ser Arg Asp Asn Ile Lys Arg Thr Ala Gly Leu Gln Met Asn 
305                 310                 315                 320 


Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Asn Ala Gln Thr 
                325                 330                 335     


Asp Leu Arg Asp Trp Thr Val Arg Glu Tyr Trp Gly Gln Gly Thr Gln 
            340                 345                 350         


Val Thr Val Ser Ser 
        355         


<210>  60
<211>  1344
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  60
gaggtgcagc tggtggagtc tgggggaggc ttggtccagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt caccttcagt agcagctaca tgagctgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcaggc attaataccg atggtagctt cacacgctac      180

gcagactccg tgaagggccg attcaccatc tccagagaca atgccaagaa cacgctgtat      240

cttcaaatga acagcctgaa atctgaggac acggctctgt attactgtgc ggtaggcggc      300

gggttaggct atggacccag gggccaggga accctggtca ctgtctcctc agcgtcgacc      360

aagggcccat cggtcttccc gctagcaccc tcctccaaga gcacctctgg gggcacagcg      420

gccctgggct gcctggtcaa ggactacttc cccgaacctg tgacggtgtc gtggaactca      480

ggcgccctga ccagcggcgt gcacaccttc ccggctgtcc tacagtcctc aggactctac      540

tccctcagca gcgtggtgac cgtgccctcc agcagcttgg gcacccagac ctacatctgc      600

aacgtgaatc acaagcccag caacaccaag gtggacaaga aagttgagcc caaatcttgt      660

gacaaaactc acacatgccc accgtgccca gcacctgaag ctgctggggg accgtcagtc      720

ttcctcttcc ccccaaaacc caaggacacc ctcatgatct cccggacccc tgaggtcaca      780

tgcgtggtgg tggacgtgag ccacgaagac cctgaggtca agttcaactg gtacgtggac      840

ggcgtggagg tgcataatgc caagacaaag ccgcgggagg agcagtacaa cagcacgtac      900

cgggtggtca gcgtcctcac cgtcctgcac caggactggc tgaatggcaa ggagtacaag      960

tgcaaggtct ccaacaaagc cctcggagcc cccatcgaga aaaccatctc caaagccaaa     1020

gggcagcccc gagaaccaca ggtgtacacc ctgcccccat cccgggatga gctgaccaag     1080

aaccaggtca gcctgacctg cctggtcaaa ggcttctatc ccagcgacat cgccgtggag     1140

tgggagagca atgggcagcc ggagaacaac tacaagacca cgcctcccgt gctggactcc     1200

gacggctcct tcttcctcta cagcaagctc accgtggaca agagcaggtg gcagcagggg     1260

aacgtcttct catgctccgt gatgcatgag gctctgcaca accactacac gcagaagagc     1320

ctctccctgt ctccgggtaa atga                                            1344


<210>  61
<211>  447
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  61

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Ser 
            20                  25                  30          


Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Asn Thr Asp Gly Ser Phe Thr Arg Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Ser Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Val Gly Gly Gly Leu Gly Tyr Gly Pro Arg Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
        115                 120                 125             


Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys 
    130                 135                 140                 


Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
145                 150                 155                 160 


Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
                165                 170                 175     


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
            180                 185                 190         


Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn 
        195                 200                 205             


Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His 
    210                 215                 220                 


Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val 
225                 230                 235                 240 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                245                 250                 255     


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
            260                 265                 270         


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        275                 280                 285             


Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
    290                 295                 300                 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
305                 310                 315                 320 


Cys Lys Val Ser Asn Lys Ala Leu Gly Ala Pro Ile Glu Lys Thr Ile 
                325                 330                 335     


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
            340                 345                 350         


Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
        355                 360                 365             


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
    370                 375                 380                 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
385                 390                 395                 400 


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
                405                 410                 415     


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            420                 425                 430         


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445         


<210>  62
<211>  1098
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  62
gaggtgcagc tggtggagtc tggaggaggc ttgatccagc ctggggggtc cctgagactc       60

tcctgtgcag cctctgggtt caccttcagt cgccgctgca tggcctggtt ccgccaggct      120

ccagggaagg agcgggagcg ggtcgcaaag ctgctgacca ctagcggtag cacatacctg      180

gcagactccg tgaagggccg attcaccatc tccagagaca attccaagaa cacggtgtat      240

cttcaaatga acagcctgag agccgaggac acggccgtgt attactgtgc ggccgacagc      300

ttcgaggacc ccacctgcac cctggtgacc agcagcggcg cctttcagta ctggggccag      360

ggcaccctgg tcaccgtgtc ctcacgtacg gtggctgcac catctgtctt catcttcccg      420

ccatctgatg agcagttgaa atctggaact gcctctgttg tgtgcctgct gaataacttc      480

tatcccagag aggccaaagt acagtggaag gtggataacg ccctccaatc gggtaactcc      540

caggagagtg tcacagagca ggacagcaag gacagcacct acagcctcag cagcaccctg      600

acgctgagca aagcagacta cgagaaacac aaagtctacg cctgcgaagt cacccatcag      660

ggcctgagct cgcccgtcac aaagagcttc aacaggggag agtgtaccgt cctaggtcag      720

cccaaggcgg ccgctgaggt gcagctggtg gagtctgggg gaggcttggt acagcctggg      780

gggtccctga gactctcctg tgcagcctct ggattcacct ttgacgacta tggcatgagc      840

tgggtccgcc aggctccagg gaagtggctg gagtgggtct cagatattag ctggaatggt      900

ggtagcacat actacgcaga ctccgtgaag ggccggttca ccatctccag agacaatgcc      960

gagaacacgc tgtatctgca aatgaacagc ctgaaacctg acgacacggc cgtgtattac     1020

tgtgcgaaaa tgggtgaagg gggatggggt gcaaatgact actggggcca ggggacccag     1080

gtcaccgtgt cctcataa                                                   1098


<210>  63
<211>  365
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  63

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Ile Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Arg Arg 
            20                  25                  30          


Cys Met Ala Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Arg Val 
        35                  40                  45              


Ala Lys Leu Leu Thr Thr Ser Gly Ser Thr Tyr Leu Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Asp Ser Phe Glu Asp Pro Thr Cys Thr Leu Val Thr Ser Ser 
            100                 105                 110         


Gly Ala Phe Gln Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125             


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
    130                 135                 140                 


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
145                 150                 155                 160 


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
                165                 170                 175     


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
            180                 185                 190         


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
        195                 200                 205             


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
    210                 215                 220                 


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys Thr Val Leu Gly Gln 
225                 230                 235                 240 


Pro Lys Ala Ala Ala Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
                245                 250                 255     


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
            260                 265                 270         


Thr Phe Asp Asp Tyr Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys 
        275                 280                 285             


Trp Leu Glu Trp Val Ser Asp Ile Ser Trp Asn Gly Gly Ser Thr Tyr 
    290                 295                 300                 


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala 
305                 310                 315                 320 


Glu Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Lys Pro Asp Asp Thr 
                325                 330                 335     


Ala Val Tyr Tyr Cys Ala Lys Met Gly Glu Gly Gly Trp Gly Ala Asn 
            340                 345                 350         


Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        355                 360                 365 


<210>  64
<211>  1095
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  64
gaggtgcagc tggtggagtc tggaggaggc ttgatccagc ctggggggtc cctgagactc       60

tcctgtgcag cctctgggtt caccttcagt cgccgctgca tggcctggtt ccgccaggct      120

ccagggaagg agcgggagcg ggtcgcaaag ctgctgacca ctagcggtag cacatacctg      180

gcagactccg tgaagggccg attcaccatc tccagagaca attccaagaa cacggtgtat      240

cttcaaatga acagcctgag agccgaggac acggccgtgt attactgtgc ggccgacagc      300

ttcgaggacc ccacctgcac cctggtgacc agcagcggcg cctttcagta ctggggccag      360

ggcaccctgg tcaccgtgtc ctcacgtacg gtggctgcac catctgtctt catcttcccg      420

ccatctgatg agcagttgaa atctggaact gcctctgttg tgtgcctgct gaataacttc      480

tatcccagag aggccaaagt acagtggaag gtggataacg ccctccaatc gggtaactcc      540

caggagagtg tcacagagca ggacagcaag gacagcacct acagcctcag cagcaccctg      600

acgctgagca aagcagacta cgagaaacac aaagtctacg cctgcgaagt cacccatcag      660

ggcctgagct cgcccgtcac aaagagcttc aacaggggag agtgtaccgt cctaggtcag      720

cccaaggcgg ccgctgaggt gcagctggtg gagtctgggg gaggcttagt gcagcctggg      780

gagtctctga cactctcctg tgtagttgct ggaagcatct tcagcttcgc catgagctgg      840

tatcgccagg ctccaggaaa agagcgcgaa ttggtcgcac gtattggttc ggatgatcgg      900

gtaacctacg cagattccgt gaagggccga tttaccatct ccagagacaa catcaagcgc      960

acggcgggcc tgcagatgaa cagcctgaaa cctgaggaca cggccgtcta ctactgcaat     1020

gcccaaacag atttgaggga ttggactgtg cgagagtact ggggccaggg gacccaggtc     1080

accgtctcct cataa                                                      1095


<210>  65
<211>  364
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  65

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Ile Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Arg Arg 
            20                  25                  30          


Cys Met Ala Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Arg Val 
        35                  40                  45              


Ala Lys Leu Leu Thr Thr Ser Gly Ser Thr Tyr Leu Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Asp Ser Phe Glu Asp Pro Thr Cys Thr Leu Val Thr Ser Ser 
            100                 105                 110         


Gly Ala Phe Gln Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125             


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
    130                 135                 140                 


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
145                 150                 155                 160 


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
                165                 170                 175     


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
            180                 185                 190         


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
        195                 200                 205             


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
    210                 215                 220                 


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys Thr Val Leu Gly Gln 
225                 230                 235                 240 


Pro Lys Ala Ala Ala Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
                245                 250                 255     


Val Gln Pro Gly Glu Ser Leu Thr Leu Ser Cys Val Val Ala Gly Ser 
            260                 265                 270         


Ile Phe Ser Phe Ala Met Ser Trp Tyr Arg Gln Ala Pro Gly Lys Glu 
        275                 280                 285             


Arg Glu Leu Val Ala Arg Ile Gly Ser Asp Asp Arg Val Thr Tyr Ala 
    290                 295                 300                 


Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ile Lys Arg 
305                 310                 315                 320 


Thr Ala Gly Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val 
                325                 330                 335     


Tyr Tyr Cys Asn Ala Gln Thr Asp Leu Arg Asp Trp Thr Val Arg Glu 
            340                 345                 350         


Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        355                 360                 


<210>  66
<211>  1362
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  66
caggtgcagc tggtgcagtc tgggggagga ttggtgcagg ctgggggctc tctgagactc       60

tcctgtgcag cctctggacg caccttcagt agttatgcca tggcctggtt ccgccaggct      120

ccagggaagg agcgtgagtt tgtagcagct attagctgga gtggtgcaaa catatacgtt      180

gcagactccg tgaagggccg attcaccatc tccagagaca acgccaagga cacggtgtat      240

ctgcaaatga acagcctgaa acctgaggac acggccgttt attactgtgc agtaaagctc      300

ggtttcgcac ctgtagaaga aaggcagtat gactactggg gccaggggac ccaggtcacc      360

gtctcctcag cgtcgaccaa gggcccatcg gtcttcccgc tagcaccctc ctccaagagc      420

acctctgggg gcacagcggc cctgggctgc ctggtcaagg actacttccc cgaacctgtg      480

acggtgtcgt ggaactcagg cgccctgacc agcggcgtgc acaccttccc ggctgtccta      540

cagtcctcag gactctactc cctcagcagc gtggtgaccg tgccctccag cagcttgggc      600

acccagacct acatctgcaa cgtgaatcac aagcccagca acaccaaggt ggacaagaaa      660

gttgagccca aatcttgtga caaaactcac acatgcccac cgtgcccagc acctgaagct      720

gctgggggac cgtcagtctt cctcttcccc ccaaaaccca aggacaccct catgatctcc      780

cggacccctg aggtcacatg cgtggtggtg gacgtgagcc acgaagaccc tgaggtcaag      840

ttcaactggt acgtggacgg cgtggaggtg cataatgcca agacaaagcc gcgggaggag      900

cagtacaaca gcacgtaccg ggtggtcagc gtcctcaccg tcctgcacca ggactggctg      960

aatggcaagg agtacaagtg caaggtctcc aacaaagccc tcggagcccc catcgagaaa     1020

accatctcca aagccaaagg gcagccccga gaaccacagg tgtacaccct gcccccatcc     1080

cgggatgagc tgaccaagaa ccaggtcagc ctgacctgcc tggtcaaagg cttctatccc     1140

agcgacatcg ccgtggagtg ggagagcaat gggcagccgg agaacaacta caagaccacg     1200

cctcccgtgc tggactccga cggctccttc ttcctctaca gcaagctcac cgtggacaag     1260

agcaggtggc agcaggggaa cgtcttctca tgctccgtga tgcatgaggc tctgcacaac     1320

cactacacgc agaagagcct ctccctgtct ccgggtaaat ga                        1362


<210>  67
<211>  453
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  67

Gln Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ala Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Ser Trp Ser Gly Ala Asn Ile Tyr Val Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asp Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Val Lys Leu Gly Phe Ala Pro Val Glu Glu Arg Gln Tyr Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Ala Ser Thr Lys Gly 
        115                 120                 125             


Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly 
    130                 135                 140                 


Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val 
145                 150                 155                 160 


Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe 
                165                 170                 175     


Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val 
            180                 185                 190         


Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val 
        195                 200                 205             


Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys 
    210                 215                 220                 


Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala 
225                 230                 235                 240 


Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
                245                 250                 255     


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
            260                 265                 270         


Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
        275                 280                 285             


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 
    290                 295                 300                 


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
305                 310                 315                 320 


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Gly Ala 
                325                 330                 335     


Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
            340                 345                 350         


Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln 
        355                 360                 365             


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
    370                 375                 380                 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
385                 390                 395                 400 


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 
                405                 410                 415     


Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
            420                 425                 430         


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
        435                 440                 445             


Leu Ser Pro Gly Lys 
    450             


<210>  68
<211>  1368
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  68
gatgtgcagc tgcaggcktc tggaggaggc tcggtgcagg cgggagggtc tctgaggctc       60

tcctgtgcag cggatgcata catctacagt aggaaccgtc tggcctggtt ccgccggtct      120

ccaggaaagg accgcgaggg agtcgcaaca atgtgtgacg gaaacacata ctatagcgac      180

tccgcgaagg gccgattcac catctcccaa gacaacgcca agaacgagct aattctgcaa      240

atgagcagcc tgagacctga ggacactgcc acgtacttct gtgcaggccg accgtcttcc      300

attgaaaatt gtggtagcct cagtctgcat gattataact tctggggcca agggacccag      360

gtcaccgtct cctcagcgtc gaccaagggc ccatcggtct tcccgctagc accctcctcc      420

aagagcacct ctgggggcac agcggccctg ggctgcctgg tcaaggacta cttccccgaa      480

cctgtgacgg tgtcgtggaa ctcaggcgcc ctgaccagcg gcgtgcacac cttcccggct      540

gtcctacagt cctcaggact ctactccctc agcagcgtgg tgaccgtgcc ctccagcagc      600

ttgggcaccc agacctacat ctgcaacgtg aatcacaagc ccagcaacac caaggtggac      660

aagaaagttg agcccaaatc ttgtgacaaa actcacacat gcccaccgtg cccagcacct      720

gaagctgctg ggggaccgtc agtcttcctc ttccccccaa aacccaagga caccctcatg      780

atctcccgga cccctgaggt cacatgcgtg gtggtggacg tgagccacga agaccctgag      840

gtcaagttca actggtacgt ggacggcgtg gaggtgcata atgccaagac aaagccgcgg      900

gaggagcagt acaacagcac gtaccgggtg gtcagcgtcc tcaccgtcct gcaccaggac      960

tggctgaatg gcaaggagta caagtgcaag gtctccaaca aagccctcgg agcccccatc     1020

gagaaaacca tctccaaagc caaagggcag ccccgagaac cacaggtgta caccctgccc     1080

ccatcccggg atgagctgac caagaaccag gtcagcctga cctgcctggt caaaggcttc     1140

tatcccagcg acatcgccgt ggagtgggag agcaatgggc agccggagaa caactacaag     1200

accacgcctc ccgtgctgga ctccgacggc tccttcttcc tctacagcaa gctcaccgtg     1260

gacaagagca ggtggcagca ggggaacgtc ttctcatgct ccgtgatgca tgaggctctg     1320

cacaaccact acacgcagaa gagcctctcc ctgtctccgg gtaaatga                  1368


<210>  69
<211>  455
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  69

Asp Val Gln Leu Gln Ala Ser Gly Gly Gly Ser Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Asp Ala Tyr Ile Tyr Ser Arg Asn 
            20                  25                  30          


Arg Leu Ala Trp Phe Arg Arg Ser Pro Gly Lys Asp Arg Glu Gly Val 
        35                  40                  45              


Ala Thr Met Cys Asp Gly Asn Thr Tyr Tyr Ser Asp Ser Ala Lys Gly 
    50                  55                  60                  


Arg Phe Thr Ile Ser Gln Asp Asn Ala Lys Asn Glu Leu Ile Leu Gln 
65                  70                  75                  80  


Met Ser Ser Leu Arg Pro Glu Asp Thr Ala Thr Tyr Phe Cys Ala Gly 
                85                  90                  95      


Arg Pro Ser Ser Ile Glu Asn Cys Gly Ser Leu Ser Leu His Asp Tyr 
            100                 105                 110         


Asn Phe Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Ala Ser Thr 
        115                 120                 125             


Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser 
    130                 135                 140                 


Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu 
145                 150                 155                 160 


Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His 
                165                 170                 175     


Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser 
            180                 185                 190         


Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys 
        195                 200                 205             


Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu 
    210                 215                 220                 


Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro 
225                 230                 235                 240 


Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
                245                 250                 255     


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
            260                 265                 270         


Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 
        275                 280                 285             


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 
    290                 295                 300                 


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
305                 310                 315                 320 


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 
                325                 330                 335     


Gly Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
            340                 345                 350         


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys 
        355                 360                 365             


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
    370                 375                 380                 


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
385                 390                 395                 400 


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
                405                 410                 415     


Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
            420                 425                 430         


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
        435                 440                 445             


Leu Ser Leu Ser Pro Gly Lys 
    450                 455 


