                         SEQUENCE LISTING

<110>  The Rockefeller University
 
<120>  COMPOSITIONS AND METHODS FOR ENHANCEMENT OF CAS9 GENE EDITING OR 
       TARGET DESTRUCTION BY CO-EXPRESSION OF HETEROLOGOUS DNA REPAIR 
       PROTEIN

<130>  076091.00047

<150>  62/516,634
<151>  2017-06-07

<160>  11    

<170>  PatentIn version 3.5

<210>  1
<211>  2279
<212>  DNA
<213>  artificial sequence

<220>
<223>  MLM3636_APP-gRNA plasmid sequence

<400>  1
gacgtcgcta gctgtacaaa aaagcaggct ttaaaggaac caattcagtc gactggatcc       60

ggtaccaagg tcgggcagga agagggccta tttcccatga ttccttcata tttgcatata      120

cgatacaagg ctgttagaga gataattaga attaatttga ctgtaaacac aaagatatta      180

gtacaaaata cgtgacgtag aaagtaataa tttcttgggt agtttgcagt tttaaaatta      240

tgttttaaaa tggactatca tatgcttacc gtaacttgaa agtatttcga tttcttggct      300

ttatatatct tgtggaaagg acgaaacacc ggagatctct gaagtgaaga gttttagagc      360

tagaaatagc aagttaaaat aaggctagtc cgttatcaac ttgaaaaagt ggcaccgagt      420

cggtgctttt tttaagcttg ggccgctcga ggtacctctc tacatatgac atgtgagcaa      480

aaggccagca aaaggccagg aaccgtaaaa aggccgcgtt gctggcgttt ttccataggc      540

tccgcccccc tgacgagcat cacaaaaatc gacgctcaag tcagaggtgg cgaaacccga      600

caggactata aagataccag gcgtttcccc ctggaagctc cctcgtgcgc tctcctgttc      660

cgaccctgcc gcttaccgga tacctgtccg cctttctccc ttcgggaagc gtggcgcttt      720

ctcatagctc acgctgtagg tatctcagtt cggtgtaggt cgttcgctcc aagctgggct      780

gtgtgcacga accccccgtt cagcccgacc gctgcgcctt atccggtaac tatcgtcttg      840

agtccaaccc ggtaagacac gacttatcgc cactggcagc agccactggt aacaggatta      900

gcagagcgag gtatgtaggc ggtgctacag agttcttgaa gtggtggcct aactacggct      960

acactagaag aacagtattt ggtatctgcg ctctgctgaa gccagttacc ttcggaaaaa     1020

gagttggtag ctcttgatcc ggcaaacaaa ccaccgctgg tagcggtggt ttttttgttt     1080

gcaagcagca gattacgcgc agaaaaaaag gatctcaaga agatcctttg atcttttcta     1140

cggggtctga cgctcagtgg aacgaaaact cacgttaagg gattttggtc atgagattat     1200

caaaaaggat cttcacctag atccttttaa attaaaaatg aagttttaaa tcaatctaaa     1260

gtatatatga gtaaacttgg tctgacagtt accaatgctt aatcagtgag gcacctatct     1320

cagcgatctg tctatttcgt tcatccatag ttgcctgact ccccgtcgtg tagataacta     1380

cgatacggga gggcttacca tctggcccca gtgctgcaat gataccgcga gacccacgct     1440

caccggctcc agatttatca gcaataaacc agccagccgg aagggccgag cgcagaagtg     1500

gtcctgcaac tttatccgcc tccatccagt ctattaattg ttgccgggaa gctagagtaa     1560

gtagttcgcc agttaatagt ttgcgcaacg ttgttgccat tgctacaggc atcgtggtgt     1620

cacgctcgtc gtttggtatg gcttcattca gctccggttc ccaacgatca aggcgagtta     1680

catgatcccc catgttgtgc aaaaaagcgg ttagctcctt cggtcctccg atcgttgtca     1740

gaagtaagtt ggccgcagtg ttatcactca tggttatggc agcactgcat aattctctta     1800

ctgtcatgcc atccgtaaga tgcttttctg tgactggtga gtactcaacc aagtcattct     1860

gagaatagtg tatgcggcga ccgagttgct cttgcccggc gtcaatacgg gataataccg     1920

cgccacatag cagaacttta aaagtgctca tcattggaaa acgttcttcg gggcgaaaac     1980

tctcaaggat cttaccgctg ttgagatcca gttcgatgta acccactcgt gcacccaact     2040

gatcttcagc atcttttact ttcaccagcg tttctgggtg agcaaaaaca ggaaggcaaa     2100

atgccgcaaa aaagggaata agggcgacac ggaaatgttg aatactcata ctcttccttt     2160

ttcaatatta ttgaagcatt tatcagggtt attgtctcat gagcggatac atatttgaat     2220

gtatttagaa aaataaacaa ataggggttc cgcgcacatt tccccgaaaa gtgccacct      2279


<210>  2
<211>  2278
<212>  DNA
<213>  artificial sequence

<220>
<223>  MLM3636_PSEN1-gR  plasmid

<400>  2
gacgtcgcta gctgtacaaa aaagcaggct ttaaaggaac caattcagtc gactggatcc       60

ggtaccaagg tcgggcagga agagggccta tttcccatga ttccttcata tttgcatata      120

cgatacaagg ctgttagaga gataattaga attaatttga ctgtaaacac aaagatatta      180

gtacaaaata cgtgacgtag aaagtaataa tttcttgggt agtttgcagt tttaaaatta      240

tgttttaaaa tggactatca tatgcttacc gtaacttgaa agtatttcga tttcttggct      300

ttatatatct tgtggaaagg acgaaacacc gttgtcgtga ctatcctccg ttttagagct      360

agaaatagca agttaaaata aggctagtcc gttatcaact tgaaaaagtg gcaccgagtc      420

ggtgcttttt ttaagcttgg gccgctcgag gtacctctct acatatgaca tgtgagcaaa      480

aggccagcaa aaggccagga accgtaaaaa ggccgcgttg ctggcgtttt tccataggct      540

ccgcccccct gacgagcatc acaaaaatcg acgctcaagt cagaggtggc gaaacccgac      600

aggactataa agataccagg cgtttccccc tggaagctcc ctcgtgcgct ctcctgttcc      660

gaccctgccg cttaccggat acctgtccgc ctttctccct tcgggaagcg tggcgctttc      720

tcatagctca cgctgtaggt atctcagttc ggtgtaggtc gttcgctcca agctgggctg      780

tgtgcacgaa ccccccgttc agcccgaccg ctgcgcctta tccggtaact atcgtcttga      840

gtccaacccg gtaagacacg acttatcgcc actggcagca gccactggta acaggattag      900

cagagcgagg tatgtaggcg gtgctacaga gttcttgaag tggtggccta actacggcta      960

cactagaaga acagtatttg gtatctgcgc tctgctgaag ccagttacct tcggaaaaag     1020

agttggtagc tcttgatccg gcaaacaaac caccgctggt agcggtggtt tttttgtttg     1080

caagcagcag attacgcgca gaaaaaaagg atctcaagaa gatcctttga tcttttctac     1140

ggggtctgac gctcagtgga acgaaaactc acgttaaggg attttggtca tgagattatc     1200

aaaaaggatc ttcacctaga tccttttaaa ttaaaaatga agttttaaat caatctaaag     1260

tatatatgag taaacttggt ctgacagtta ccaatgctta atcagtgagg cacctatctc     1320

agcgatctgt ctatttcgtt catccatagt tgcctgactc cccgtcgtgt agataactac     1380

gatacgggag ggcttaccat ctggccccag tgctgcaatg ataccgcgag acccacgctc     1440

accggctcca gatttatcag caataaacca gccagccgga agggccgagc gcagaagtgg     1500

tcctgcaact ttatccgcct ccatccagtc tattaattgt tgccgggaag ctagagtaag     1560

tagttcgcca gttaatagtt tgcgcaacgt tgttgccatt gctacaggca tcgtggtgtc     1620

acgctcgtcg tttggtatgg cttcattcag ctccggttcc caacgatcaa ggcgagttac     1680

atgatccccc atgttgtgca aaaaagcggt tagctccttc ggtcctccga tcgttgtcag     1740

aagtaagttg gccgcagtgt tatcactcat ggttatggca gcactgcata attctcttac     1800

tgtcatgcca tccgtaagat gcttttctgt gactggtgag tactcaacca agtcattctg     1860

agaatagtgt atgcggcgac cgagttgctc ttgcccggcg tcaatacggg ataataccgc     1920

gccacatagc agaactttaa aagtgctcat cattggaaaa cgttcttcgg ggcgaaaact     1980

ctcaaggatc ttaccgctgt tgagatccag ttcgatgtaa cccactcgtg cacccaactg     2040

atcttcagca tcttttactt tcaccagcgt ttctgggtga gcaaaaacag gaaggcaaaa     2100

tgccgcaaaa aagggaataa gggcgacacg gaaatgttga atactcatac tcttcctttt     2160

tcaatattat tgaagcattt atcagggtta ttgtctcatg agcggataca tatttgaatg     2220

tatttagaaa aataaacaaa taggggttcc gcgcacattt ccccgaaaag tgccacct       2278


<210>  3
<211>  9271
<212>  DNA
<213>  artificial sequence

<220>
<223>  pCas9_2A_GFP plasmid

<400>  3
actagttatt aatagtaatc aattacgggg tcattagttc atagcccata tatggagttc       60

cgcgttacat aacttacggt aaatggcccg cctggctgac cgcccaacga cccccgccca      120

ttgacgtcaa taatgacgta tgttcccata gtaacgccaa tagggacttt ccattgacgt      180

caatgggtgg actatttacg gtaaactgcc cacttggcag tacatcaagt gtatcatatg      240

ccaagtacgc cccctattga cgtcaatgac ggtaaatggc ccgcctggca ttatgcccag      300

tacatgacct tatgggactt tcctacttgg cagtacatct acgtattagt catcgctatt      360

accatgggtc gaggtgagcc ccacgttctg cttcactctc cccatctccc ccccctcccc      420

acccccaatt ttgtatttat ttatttttta attattttgt gcagcgatgg gggcgggggg      480

ggggggggcg cgcgccaggc ggggcggggc ggggcgaggg gcggggcggg gcgaggcgga      540

gaggtgcggc ggcagccaat cagagcggcg cgctccgaaa gtttcctttt atggcgaggc      600

ggcggcggcg gcggccctat aaaaagcgaa gcgcgcggcg ggcgggagtc gctgcgttgc      660

cttcgccccg tgccccgctc cgcgccgcct cgcgccgccc gccccggctc tgactgaccg      720

cgttactccc acaggtgagc gggcgggacg gcccttctcc tccgggctgt aattagcgct      780

tggtttaatg acggctcgtt tcttttctgt ggctgcgtga aagccttaaa gggctccggg      840

agggcccttt gtgcgggggg gagcggctcg gggggtgcgt gcgtgtgtgt gtgcgtgggg      900

agcgccgcgt gcggcccgcg ctgcccggcg gctgtgagcg ctgcgggcgc ggcgcggggc      960

tttgtgcgct ccgcgtgtgc gcgaggggag cgcggccggg ggcggtgccc cgcggtgcgg     1020

gggggctgcg aggggaacaa aggctgcgtg cggggtgtgt gcgtgggggg gtgagcaggg     1080

ggtgtgggcg cggcggtcgg gctgtaaccc ccccctgcac ccccctcccc gagttgctga     1140

gcacggcccg gcttcgggtg cggggctccg tacggggcgt ggcgcggggc tcgccgtgcc     1200

gggcgggggg tggcggcagg tgggggtgcc gggcggggcg gggccgcctc gggccgggga     1260

gggctcgggg gaggggcgcg gcggcccccg gagcgccggc ggctgtcgag gcgcggcgag     1320

ccgcagccat tgccttttat ggtaatcgtg cgagagggcg cagggacttc ctttgtccca     1380

aatctgtgcg gagccgaaat ctgggaggcg ccgccgcacc ccctctagcg ggcgcggggc     1440

gaagcggtgc ggcgccggca ggaaggaaat gggcggggag ggccttcgtg cgtcgccgcg     1500

ccgccgtccc cttctccatc tccagcctcg gggctgtccg cagggggacg gctgccttcg     1560

ggggggacgg ggcagggcgg ggttcggctt ctggcgtgtg accggcggct ctagtgcctc     1620

tgctaaccat gttcatgcct tcttcttttt cctacagctc ctgggcaacg tgctggttat     1680

tgtgctgtct catcattttg gcaaagaatt cgcggccgcc accatggaca agaagtactc     1740

cattgggctc gatatcggca caaacagcgt cggctgggcc gtcattacgg acgagtacaa     1800

ggtgccgagc aaaaaattca aagttctggg caataccgat cgccacagca taaagaagaa     1860

cctcattggc gccctcctgt tcgactccgg ggagacggcc gaagccacgc ggctcaaaag     1920

aacagcacgg cgcagatata cccgcagaaa gaatcggatc tgctacctgc aggagatctt     1980

tagtaatgag atggctaagg tggatgactc tttcttccat aggctggagg agtccttttt     2040

ggtggaggag gataaaaagc acgagcgcca cccaatcttt ggcaatatcg tggacgaggt     2100

ggcgtaccat gaaaagtacc caaccatata tcatctgagg aagaagcttg tagacagtac     2160

tgataaggct gacttgcggt tgatctatct cgcgctggcg catatgatca aatttcgggg     2220

acacttcctc atcgaggggg acctgaaccc agacaacagc gatgtcgaca aactctttat     2280

ccaactggtt cagacttaca atcagctttt cgaagagaac ccgatcaacg catccggagt     2340

tgacgccaaa gcaatcctga gcgctaggct gtccaaatcc cggcggctcg aaaacctcat     2400

cgcacagctc cctggggaga agaagaacgg cctgtttggt aatcttatcg ccctgtcact     2460

cgggctgacc cccaacttta aatctaactt cgacctggcc gaagatgcca agcttcaact     2520

gagcaaagac acctacgatg atgatctcga caatctgctg gcccagatcg gcgaccagta     2580

cgcagacctt tttttggcgg caaagaacct gtcagacgcc attctgctga gtgatattct     2640

gcgagtgaac acggagatca ccaaagctcc gctgagcgct agtatgatca agcgctatga     2700

tgagcaccac caagacttga ctttgctgaa ggcccttgtc agacagcaac tgcctgagaa     2760

gtacaaggaa attttcttcg atcagtctaa aaatggctac gccggataca ttgacggcgg     2820

agcaagccag gaggaatttt acaaatttat taagcccatc ttggaaaaaa tggacggcac     2880

cgaggagctg ctggtaaagc ttaacagaga agatctgttg cgcaaacagc gcactttcga     2940

caatggaagc atcccccacc agattcacct gggcgaactg cacgctatcc tcaggcggca     3000

agaggatttc tacccctttt tgaaagataa cagggaaaag attgagaaaa tcctcacatt     3060

tcggataccc tactatgtag gccccctcgc ccggggaaat tccagattcg cgtggatgac     3120

tcgcaaatca gaagagacca tcactccctg gaacttcgag gaagtcgtgg ataagggggc     3180

ctctgcccag tccttcatcg aaaggatgac taactttgat aaaaatctgc ctaacgaaaa     3240

ggtgcttcct aaacactctc tgctgtacga gtacttcaca gtttataacg agctcaccaa     3300

ggtcaaatac gtcacagaag ggatgagaaa gccagcattc ctgtctggag agcagaagaa     3360

agctatcgtg gacctcctct tcaagacgaa ccggaaagtt accgtgaaac agctcaaaga     3420

agactatttc aaaaagattg aatgtttcga ctctgttgaa atcagcggag tggaggatcg     3480

cttcaacgca tccctgggaa cgtatcacga tctcctgaaa atcattaaag acaaggactt     3540

cctggacaat gaggagaacg aggacattct tgaggacatt gtcctcaccc ttacgttgtt     3600

tgaagatagg gagatgattg aagaacgctt gaaaacttac gctcatctct tcgacgacaa     3660

agtcatgaaa cagctcaaga ggcgccgata tacaggatgg gggcggctgt caagaaaact     3720

gatcaatggg atccgagaca agcagagtgg aaagacaatc ctggattttc ttaagtccga     3780

tggatttgcc aaccggaact tcatgcagtt gatccatgat gactctctca cctttaagga     3840

ggacatccag aaagcacaag tttctggcca gggggacagt cttcacgagc acatcgctaa     3900

tcttgcaggt agcccagcta tcaaaaaggg aatactgcag accgttaagg tcgtggatga     3960

actcgtcaaa gtaatgggaa ggcataagcc cgagaatatc gttatcgaga tggcccgaga     4020

gaaccaaact acccagaagg gacagaagaa cagtagggaa aggatgaaga ggattgaaga     4080

gggtataaaa gaactggggt cccaaatcct taaggaacac ccagttgaaa acacccagct     4140

tcagaatgag aagctctacc tgtactacct gcagaacggc agggacatgt acgtggatca     4200

ggaactggac atcaatcggc tctccgacta cgacgtggat catatcgtgc cccagtcttt     4260

tctcaaagat gattctattg ataataaagt gttgacaaga tccgataaaa atagagggaa     4320

gagtgataac gtcccctcag aagaagttgt caagaaaatg aaaaattatt ggcggcagct     4380

gctgaacgcc aaactgatca cacaacggaa gttcgataat ctgactaagg ctgaacgagg     4440

tggcctgtct gagttggata aagccggctt catcaaaagg cagcttgttg agacacgcca     4500

gatcaccaag cacgtggccc aaattctcga ttcacgcatg aacaccaagt acgatgaaaa     4560

tgacaaactg attcgagagg tgaaagttat tactctgaag tctaagctgg tctcagattt     4620

cagaaaggac tttcagtttt ataaggtgag agagatcaac aattaccacc atgcgcatga     4680

tgcctacctg aatgcagtgg taggcactgc acttatcaaa aaatatccca agcttgaatc     4740

tgaatttgtt tacggagact ataaagtgta cgatgttagg aaaatgatcg caaagtctga     4800

gcaggaaata ggcaaggcca ccgctaagta cttcttttac agcaatatta tgaatttttt     4860

caagaccgag attacactgg ccaatggaga gattcggaag cgaccactta tcgaaacaaa     4920

cggagaaaca ggagaaatcg tgtgggacaa gggtagggat ttcgcgacag tccggaaggt     4980

cctgtccatg ccgcaggtga acatcgttaa aaagaccgaa gtacagaccg gaggcttctc     5040

caaggaaagt atcctcccga aaaggaacag cgacaagctg atcgcacgca aaaaagattg     5100

ggaccccaag aaatacggcg gattcgattc tcctacagtc gcttacagtg tactggttgt     5160

ggccaaagtg gagaaaggga agtctaaaaa actcaaaagc gtcaaggaac tgctgggcat     5220

cacaatcatg gagcgatcaa gcttcgaaaa aaaccccatc gactttctcg aggcgaaagg     5280

atataaagag gtcaaaaaag acctcatcat taagcttccc aagtactctc tctttgagct     5340

tgaaaacggc cggaaacgaa tgctcgctag tgcgggcgag ctgcagaaag gtaacgagct     5400

ggcactgccc tctaaatacg ttaatttctt gtatctggcc agccactatg aaaagctcaa     5460

agggtctccc gaagataatg agcagaagca gctgttcgtg gaacaacaca aacactacct     5520

tgatgagatc atcgagcaaa taagcgaatt ctccaaaaga gtgatcctcg ccgacgctaa     5580

cctcgataag gtgctttctg cttacaataa gcacagggat aagcccatca gggagcaggc     5640

agaaaacatt atccacttgt ttactctgac caacttgggc gcgcctgcag ccttcaagta     5700

cttcgacacc accatagaca gaaagcggta cacctctaca aaggaggtcc tggacgccac     5760

actgattcat cagtcaatta cggggctcta tgaaacaaga atcgacctct ctcagctcgg     5820

tggagacagc agggctgacc ccaagaagaa gaggaaggtg aggtccggcg gcggagaggg     5880

cagaggaagt cttctaacat gcggtgacgt ggaggagaat cccggcccaa tggtgagcaa     5940

gggcgaggag ctgttcaccg gggtggtgcc catcctggtc gagctggacg gcgacgtaaa     6000

cggccacaag ttcagcgtgt ccggcgaggg cgagggcgat gccacctacg gcaagctgac     6060

cctgaagttc atctgcacca ccggcaagct gcccgtgccc tggcccaccc tcgtgaccac     6120

cctgacctac ggcgtgcagt gcttcagccg ctaccccgac cacatgaagc agcacgactt     6180

cttcaagtcc gccatgcccg aaggctacgt ccaggagcgc accatcttct tcaaggacga     6240

cggcaactac aagacccgcg ccgaggtgaa gttcgagggc gacaccctgg tgaaccgcat     6300

cgagctgaag ggcatcgact tcaaggagga cggcaacatc ctggggcaca agctggagta     6360

caactacaac agccacaacg tctatatcat ggccgacaag cagaagaacg gcatcaaggt     6420

gaacttcaag atccgccaca acatcgagga cggcagcgtg cagctcgccg accactacca     6480

gcagaacacc cccatcggcg acggccccgt gctgctgccc gacaaccact acctgagcac     6540

ccagtccgcc ctgagcaaag accccaacga gaagcgcgat cacatggtcc tgctggagtt     6600

cgtgaccgcc gccgggatca ctctcggcat ggacgagctg tacaagtaac tgcagcgcgg     6660

ggatctcatg ctggagttct tcgcccaccc caacttgttt attgcagctt ataatggtta     6720

caaataaagc aatagcatca caaatttcac aaataaagca tttttttcac tgcattctag     6780

ttgtggtttg tccaaactca tcaatgtatc ttatcatgtc tgtataccgt cgacctctag     6840

ctagagcttg gcgtaatcat ggtcatagct gtttcctgtg tgaaattgtt atccgctcac     6900

aattccacac aacatacgag ccggaagcat aaagtgtaaa gcctagggtg cctaatgagt     6960

gagctaactc acattaattg cgttgcgctc actgcccgct ttccagtcgg gaaacctgtc     7020

gtgccagctg cattaatgaa tcggccaacg cgcggggaga ggcggtttgc gtattgggcg     7080

ctcttccgct tcctcgctca ctgactcgct gcgctcggtc gttcggctgc ggcgagcggt     7140

atcagctcac tcaaaggcgg taatacggtt atccacagaa tcaggggata acgcaggaaa     7200

gaacatgtga gcaaaaggcc agcaaaaggc caggaaccgt aaaaaggccg cgttgctggc     7260

gtttttccat aggctccgcc cccctgacga gcatcacaaa aatcgacgct caagtcagag     7320

gtggcgaaac ccgacaggac tataaagata ccaggcgttt ccccctggaa gctccctcgt     7380

gcgctctcct gttccgaccc tgccgcttac cggatacctg tccgcctttc tcccttcggg     7440

aagcgtggcg ctttctcata gctcacgctg taggtatctc agttcggtgt aggtcgttcg     7500

ctccaagctg ggctgtgtgc acgaaccccc cgttcagccc gaccgctgcg ccttatccgg     7560

taactatcgt cttgagtcca acccggtaag acacgactta tcgccactgg cagcagccac     7620

tggtaacagg attagcagag cgaggtatgt aggcggtgct acagagttct tgaagtggtg     7680

gcctaactac ggctacacta gaagaacagt atttggtatc tgcgctctgc tgaagccagt     7740

taccttcgga aaaagagttg gtagctcttg atccggcaaa caaaccaccg ctggtagcgg     7800

tggttttttt gtttgcaagc agcagattac gcgcagaaaa aaaggatctc aagaagatcc     7860

tttgatcttt tctacggggt ctgacgctca gtggaacgaa aactcacgtt aagggatttt     7920

ggtcatgaga ttatcaaaaa ggatcttcac ctagatcctt ttaaattaaa aatgaagttt     7980

taaatcaatc taaagtatat atgagtaaac ttggtctgac agttaccaat gcttaatcag     8040

tgaggcacct atctcagcga tctgtctatt tcgttcatcc atagttgcct gactccccgt     8100

cgtgtagata actacgatac gggagggctt accatctggc cccagtgctg caatgatacc     8160

gcgagaccca cgctcaccgg ctccagattt atcagcaata aaccagccag ccggaagggc     8220

cgagcgcaga agtggtcctg caactttatc cgcctccatc cagtctatta attgttgccg     8280

ggaagctaga gtaagtagtt cgccagttaa tagtttgcgc aacgttgttg ccattgctac     8340

aggcatcgtg gtgtcacgct cgtcgtttgg tatggcttca ttcagctccg gttcccaacg     8400

atcaaggcga gttacatgat cccccatgtt gtgcaaaaaa gcggttagct ccttcggtcc     8460

tccgatcgtt gtcagaagta agttggccgc agtgttatca ctcatggtta tggcagcact     8520

gcataattct cttactgtca tgccatccgt aagatgcttt tctgtgactg gtgagtactc     8580

aaccaagtca ttctgagaat agtgtatgcg gcgaccgagt tgctcttgcc cggcgtcaat     8640

acgggataat accgcgccac atagcagaac tttaaaagtg ctcatcattg gaaaacgttc     8700

ttcggggcga aaactctcaa ggatcttacc gctgttgaga tccagttcga tgtaacccac     8760

tcgtgcaccc aactgatctt cagcatcttt tactttcacc agcgtttctg ggtgagcaaa     8820

aacaggaagg caaaatgccg caaaaaaggg aataagggcg acacggaaat gttgaatact     8880

catactcttc ctttttcaat attattgaag catttatcag ggttattgtc tcatgagcgg     8940

atacatattt gaatgtattt agaaaaataa acaaataggg gttccgcgca catttccccg     9000

aaaagtgcca cctgacgtcg acggatcggg agatcgatct cccgatcccc tagggtcgac     9060

tctcagtaca atctgctctg atgccgcata gttaagccag tatctgctcc ctgcttgtgt     9120

gttggaggtc gctgagtagt gcgcgagcaa aatttaagct acaacaaggc aaggcttgac     9180

cgacaattgc atgaagaatc tgcttagggt taggcgtttt gcgctgcttc gcgatgtacg     9240

ggccagatat acgcgttgac attgattatt g                                    9271


<210>  4
<211>  8202
<212>  DNA
<213>  artificial sequence

<220>
<223>  pCS2+_EF1a_RexA_3xFLAG_NLS plasmid

<400>  4
gtaattcata caaaaggact cgcccctgcc ttggggaatc ccagggaccg tcgttaaact       60

cccactaacg tagaacccag agatcgctgc gttcccgccc cctcacccgc ccgctctcgt      120

catcactgag gtggagaaga gcatgcgtga ggctccggtg cccgtcagtg ggcagagcgc      180

acatcgccca cagtccccga gaagttgggg ggaggggtcg gcaattgaac cggtgcctag      240

agaaggtggc gcggggtaaa ctgggaaagt gatgtcgtgt actggctccg cctttttccc      300

gagggtgggg gagaaccgta tataagtgca gtagtcgccg tgaacgttct ttttcgcaac      360

gggtttgccg ccagaacaca ggtaagtgcc gtgtgtggtt cccgcgggcc tggcctcttt      420

acgggttatg gcccttgcgt gccttgaatt acttccacgc ccctggctgc agtacgtgat      480

tcttgatccc gagcttcggg ttggaagtgg gtgggagagt tcgaggcctt gcgcttaagg      540

agccccttcg cctcgtgctt gagttgaggc ctggcttggg cgctggggcc gccgcgtgcg      600

aatctggtgg caccttcgcg cctgtctcgc tgctttcgat aagtctctag ccatttaaaa      660

tttttgatga cctgctgcga cgcttttttt ctggcaagat agtcttgtaa atgcgggcca      720

agatctgcac actggtattt cggtttttgg ggccgcgggc ggcgacgggg cccgtgcgtc      780

ccagcgcaca tgttcggcga ggcggggcct gcgagcgcgg ccaccgagaa tcggacgggg      840

gtagtctcaa gctggccggc ctgctctggt gcctggcctc gcgccgccgt gtatcgcccc      900

gccctgggcg gcaaggctgg cccggtcggc accagttgcg tgagcggaaa gatggccgct      960

tcccggccct gctgcaggga gctcaaaatg gaggacgcgg cgctcgggag agcgggcggg     1020

tgagtcaccc acacaaagga aaagggcctt tccgtcctca gccgtcgctt catgtgactc     1080

cacggagtac cgggcgccgt ccaggcacct cgattagttc tcgagctttt ggagtacgtc     1140

gtctttaggt tggggggagg ggttttatgc gatggagttt ccccacactg agtgggtgga     1200

gactgaagtt aggccagctt ggcacttgat gtaattctcc ttggaatttg ccctttttga     1260

gtttggatct tggttcattc tcaagcctca gacagtggtt caaagttttt ttcttccatt     1320

tcaggtgtcg tgagactcgt ttagtgaacc gtcagatcgc ctggagacgc catccacgct     1380

gttttgacct ccatagaaga caccgggacc gatccagcct ccgcggcccc gaattcgcca     1440

ccatgatatc ttttgctcca ttcctgtccc ccgaggcaat caagcacctc caggaaaacg     1500

aaagatgtag ggatcagtcc caaaaaagaa cggcacagca aatagaggct atctatacga     1560

gtggccagaa catacttgtt agcgcttctg cagggagcgg gaagaccttc gtcatggttg     1620

agagaattct ggacaaaatc ttgagaggcg tatccataga tcggttgttc atttctactt     1680

tcaccgtgaa ggcagccact gagcttcgag agcgcattga aaataaattg tacagccaga     1740

ttgcgcaaac aactgacttt cagatgaagg tatatctgac cgagcaactt cagtctctgt     1800

gtcaagcgga cataggcacg atggatgcat tcgcccagaa agtggtttcc cgatatggct     1860

actccatcgg aatatcctca cagtttcgaa taatgcaaga taaagcagag caagacgttt     1920

tgaagcaaga agtcttttct aagcttttta atgagtttat gaatcaaaaa gaggccccag     1980

tctttcgagc gttggttaaa aatttctctg ggaactgcaa agacacctct gcattcagag     2040

aattggtcta cacctgttat agctttagcc aatcaactga aaacccgaag atatggttgc     2100

aggaaaattt cctttccgca gcaaaaacgt accagaggct ggaagatatt ccagatcatg     2160

atattgaact cttgcttctt gcaatgcaag atacggcgaa ccaacttcgc gatgtcacgg     2220

acatggagga ctatggtcag ctcactaagg cagggagccg atcagcaaag tacactaagc     2280

accttacgat tatagagaag ctgagcgact gggttaggga ttttaaatgc ctctacggta     2340

aagctggtct ggacagattg atacgggacg ttacaggact gattcctagc ggtaacgatg     2400

ttaccgtgtc taaggtaaag taccctgtat tcaaaacctt gcaccaaaag cttaagcaat     2460

ttaggcatct ggaaacgatc ctgatgtacc aaaaagactg tttctccctg ctcgaacagt     2520

tgcaagactt tgtattggcc ttttcagagg cttacttggc tgtgaagatt caggaatctg     2580

cgttcgaatt cagtgatatt gctcacttcg cgattaaaat cctggaggaa aataccgata     2640

ttcgccagag ctatcaacag cattatcacg aagtaatggt ggacgagtat caggataata     2700

accatatgca agaacgcctc ctcacactgc tctcaaacgg tcacaacaga tttatggtgg     2760

gtgatattaa gcagtcaatc tatcgattta gacaagccga cccgcaaatt tttaaccaga     2820

agtttcggga ttatcagaaa aagcccgagc agggaaaagt catcctcctg aaagagaatt     2880

tccgctccca gagtgaagtc cttaacgtct caaatgccgt ctttagccac cttatggacg     2940

aaagtgtcgg tgatgtactg tatgacgagc agcatcagtt gattgcagga agccatgccc     3000

aaaccgtccc gtacctcgac agacgcgcgc agctcctcct gtacaattcc gataaagatg     3060

acgggaatgc accgagcgac tctgaaggca taagcttctc tgaagttaca attgtcgcta     3120

aagagatcat caagctgcac aacgataagg gagtaccttt tgaagatatt actctgctcg     3180

tgtcttcccg gaccagaaac gatattatta gccatacatt taaccagtat ggaattccaa     3240

tagctacgga tgggggtcaa cagaattatc tgaaatccgt agaggtgatg gttatgctgg     3300

acacactcag aacgataaat aatccacgga acgactacgc actcgttgca ttgttgaggt     3360

ccccgatgtt tgctttcgac gaggacgact tggcgaggat cgctttgcaa aaagataatg     3420

agctggataa ggactgtctc tatgataaaa ttcagcgagc ggtaatcggc cggggtgcac     3480

accccgagtt gatacacgat accctgcttg ggaaacttaa tgttttcctc aagacattga     3540

aatcttggcg ccggtatgcg aagctcggct ctctctatga cctcatctgg aaaattttta     3600

atgaccgctt ttactttgac ttcgtggcaa gtcaagccaa ggcagaacag gcgcaggcca     3660

acctctatgc gctcgccctt cgggctaacc aatttgaaaa gtcagggtat aaggggttgt     3720

accgcttcat aaagatgatt gataaagtcc ttgaaactca gaatgacttg gcggacgtag     3780

aagtagcgac tccgaagcag gcagttaatc tgatgacaat tcataaaagt aaaggactgc     3840

aattcccata tgtttttatc ttgaattgcg acaaacgatt tagtatgacg gatatccaca     3900

agtcatttat actgaatagg caacatggta ttggtattaa gtacttggcc gatataaaag     3960

gcttgttggg ggaaacaaca cttaatagcg ttaaggtttc catggagaca ttgccatacc     4020

aactgaacaa gcaagagctc cgactcgcca cactgagtga ggaaatgaga ctcctgtatg     4080

tggcaatgac aagagctgag aagaaggtgt actttatcgg gaaggcctca aaaagtaaaa     4140

gccaagagat tactgatccc aaaaagctgg gtaaattgct tccccttgcg ttgagagagc     4200

agctgctcac atttcaagat tggcttcttg cgattgctga catattttcc actgaagatc     4260

tgtattttga cgtgaggttc attgaagact ccgacctcac tcaagaaagc gtgggtcgat     4320

tgcagactcc tcagctcctc aaccccgacg atctgaaaga caaccggcag tccgagacaa     4380

tagcacgggc attggatatg cttgaagcgg tttcccaact taatgccaat tatgaagcgg     4440

cgatacacct cccaaccgtc agaactccct cacaacttaa ggccacctat gagccgttgc     4500

tggaacccat cggtgtcgac ataattgaga aatcatctag gtctctttcc gactttacac     4560

tcccccactt tagcaaaaag gctaaagtag aagcgtcaca cattggctca gccctccacc     4620

aactcatgca agtcctgccc ttgagtaagc caatcaacca gcagaccctc ctcgatgccc     4680

ttcgaggcat tgactcaaat gaggaagtca agacagcgtt ggatcttaaa aaaattgagt     4740

cttttttttg cgacacatca ctcggccagt ttttccagac ataccaaaag catctgtata     4800

gagaagcgcc attcgctatt ttgaaactgg atccaataag tcaagaggag tatgtcctga     4860

gagggattat cgatgcgtac tttctgtttg atgatcatat tgtacttgta gactacaaaa     4920

cggacaaata taaacagcct atcgaactga aaaagcgcta ccaacaacag ttggaactgt     4980

acgcggaggc cctcacccaa acatataaac tccccgtcac aaagagatat ttggttctca     5040

tgggtggtgg caaacctgaa attgtagagg tcggctccgg agactataag gaccacgacg     5100

gagactacaa ggatcatgat attgattaca aagacgatga cgataagggc tccggcaaaa     5160

ggccggcggc cacgaaaaag gccggccagg caaaaaagaa aaagtgaatc tagaactata     5220

gtgagtcgta ttacgtagat ccagacatga taagatacat tgatgagttt ggacaaacca     5280

caactagaat gcagtgaaaa aaatgcttta tttgtgaaat ttgtgatgct attgctttat     5340

ttgtaaccat tataagctgc aataaacaag ttaacaacaa caattgcatt cattttatgt     5400

ttcaggttca gggggaggtg tgggaggttt tttaattcgc ggccgcggcg ccaatgcatt     5460

gggcccggta cccagctttt gttcccttta gtgagggtta attgcgcgct tggcgtaatc     5520

atggtcatag ctgtttcctg tgtgaaattg ttatccgctc acaattccac acaacatacg     5580

agccggaagc ataaagtgta aagcctgggg tgcctaatga gtgagctaac tcacattaat     5640

tgcgttgcgc tcactgcccg ctttccagtc gggaaacctg tcgtgccagc tgcattaatg     5700

aatcggccaa cgcgcgggga gaggcggttt gcgtattggg cgctcttccg cttcctcgct     5760

cactgactcg ctgcgctcgg tcgttcggct gcggcgagcg gtatcagctc actcaaaggc     5820

ggtaatacgg ttatccacag aatcagggga taacgcagga aagaacatgt gagcaaaagg     5880

ccagcaaaag gccaggaacc gtaaaaaggc cgcgttgctg gcgtttttcc ataggctccg     5940

cccccctgac gagcatcaca aaaatcgacg ctcaagtcag aggtggcgaa acccgacagg     6000

actataaaga taccaggcgt ttccccctgg aagctccctc gtgcgctctc ctgttccgac     6060

cctgccgctt accggatacc tgtccgcctt tctcccttcg ggaagcgtgg cgctttctca     6120

tagctcacgc tgtaggtatc tcagttcggt gtaggtcgtt cgctccaagc tgggctgtgt     6180

gcacgaaccc cccgttcagc ccgaccgctg cgccttatcc ggtaactatc gtcttgagtc     6240

caacccggta agacacgact tatcgccact ggcagcagcc actggtaaca ggattagcag     6300

agcgaggtat gtaggcggtg ctacagagtt cttgaagtgg tggcctaact acggctacac     6360

tagaaggaca gtatttggta tctgcgctct gctgaagcca gttaccttcg gaaaaagagt     6420

tggtagctct tgatccggca aacaaaccac cgctggtagc ggtggttttt ttgtttgcaa     6480

gcagcagatt acgcgcagaa aaaaaggatc tcaagaagat cctttgatct tttctacggg     6540

gtctgacgct cagtggaacg aaaactcacg ttaagggatt ttggtcatga gattatcaaa     6600

aaggatcttc acctagatcc ttttaaatta aaaatgaagt tttaaatcaa tctaaagtat     6660

atatgagtaa acttggtctg acagttacca atgcttaatc agtgaggcac ctatctcagc     6720

gatctgtcta tttcgttcat ccatagttgc ctgactcccc gtcgtgtaga taactacgat     6780

acgggagggc ttaccatctg gccccagtgc tgcaatgata ccgcgagacc cacgctcacc     6840

ggctccagat ttatcagcaa taaaccagcc agccggaagg gccgagcgca gaagtggtcc     6900

tgcaacttta tccgcctcca tccagtctat taattgttgc cgggaagcta gagtaagtag     6960

ttcgccagtt aatagtttgc gcaacgttgt tgccattgct acaggcatcg tggtgtcacg     7020

ctcgtcgttt ggtatggctt cattcagctc cggttcccaa cgatcaaggc gagttacatg     7080

atcccccatg ttgtgcaaaa aagcggttag ctccttcggt cctccgatcg ttgtcagaag     7140

taagttggcc gcagtgttat cactcatggt tatggcagca ctgcataatt ctcttactgt     7200

catgccatcc gtaagatgct tttctgtgac tggtgagtac tcaaccaagt cattctgaga     7260

atagtgtatg cggcgaccga gttgctcttg cccggcgtca atacgggata ataccgcgcc     7320

acatagcaga actttaaaag tgctcatcat tggaaaacgt tcttcggggc gaaaactctc     7380

aaggatctta ccgctgttga gatccagttc gatgtaaccc actcgtgcac ccaactgatc     7440

ttcagcatct tttactttca ccagcgtttc tgggtgagca aaaacaggaa ggcaaaatgc     7500

cgcaaaaaag ggaataaggg cgacacggaa atgttgaata ctcatactct tcctttttca     7560

atattattga agcatttatc agggttattg tctcatgagc ggatacatat ttgaatgtat     7620

ttagaaaaat aaacaaatag gggttccgcg cacatttccc cgaaaagtgc cacctaaatt     7680

gtaagcgtta atattttgtt aaaattcgcg ttaaattttt gttaaatcag ctcatttttt     7740

aaccaatagg ccgaaatcgg caaaatccct tataaatcaa aagaatagac cgagataggg     7800

ttgagtgttg ttccagtttg gaacaagagt ccactattaa agaacgtgga ctccaacgtc     7860

aaagggcgaa aaaccgtcta tcagggcgat ggcccactac gtgaaccatc accctaatca     7920

agttttttgg ggtcgaggtg ccgtaaagca ctaaatcgga accctaaagg gagcccccga     7980

tttagagctt gacggggaaa gccggcgaac gtggcgagaa aggaagggaa gaaagcgaaa     8040

ggagcgggcg ctagggcgct ggcaagtgta gcggtcacgc tgcgcgtaac caccacaccc     8100

gccgcgctta atgcgccgct acagggcgcg tcccattcgc cattcaggct gcgcaactgt     8160

tgggaagggc gatcggtgcg ggcctcttcg ctattacgcc ag                        8202


<210>  5
<211>  8202
<212>  DNA
<213>  artificial sequence

<220>
<223>  pCS2+_EF1a_RexA_ND_3xFLAG_NLS plasmid

<400>  5
gtaattcata caaaaggact cgcccctgcc ttggggaatc ccagggaccg tcgttaaact       60

cccactaacg tagaacccag agatcgctgc gttcccgccc cctcacccgc ccgctctcgt      120

catcactgag gtggagaaga gcatgcgtga ggctccggtg cccgtcagtg ggcagagcgc      180

acatcgccca cagtccccga gaagttgggg ggaggggtcg gcaattgaac cggtgcctag      240

agaaggtggc gcggggtaaa ctgggaaagt gatgtcgtgt actggctccg cctttttccc      300

gagggtgggg gagaaccgta tataagtgca gtagtcgccg tgaacgttct ttttcgcaac      360

gggtttgccg ccagaacaca ggtaagtgcc gtgtgtggtt cccgcgggcc tggcctcttt      420

acgggttatg gcccttgcgt gccttgaatt acttccacgc ccctggctgc agtacgtgat      480

tcttgatccc gagcttcggg ttggaagtgg gtgggagagt tcgaggcctt gcgcttaagg      540

agccccttcg cctcgtgctt gagttgaggc ctggcttggg cgctggggcc gccgcgtgcg      600

aatctggtgg caccttcgcg cctgtctcgc tgctttcgat aagtctctag ccatttaaaa      660

tttttgatga cctgctgcga cgcttttttt ctggcaagat agtcttgtaa atgcgggcca      720

agatctgcac actggtattt cggtttttgg ggccgcgggc ggcgacgggg cccgtgcgtc      780

ccagcgcaca tgttcggcga ggcggggcct gcgagcgcgg ccaccgagaa tcggacgggg      840

gtagtctcaa gctggccggc ctgctctggt gcctggcctc gcgccgccgt gtatcgcccc      900

gccctgggcg gcaaggctgg cccggtcggc accagttgcg tgagcggaaa gatggccgct      960

tcccggccct gctgcaggga gctcaaaatg gaggacgcgg cgctcgggag agcgggcggg     1020

tgagtcaccc acacaaagga aaagggcctt tccgtcctca gccgtcgctt catgtgactc     1080

cacggagtac cgggcgccgt ccaggcacct cgattagttc tcgagctttt ggagtacgtc     1140

gtctttaggt tggggggagg ggttttatgc gatggagttt ccccacactg agtgggtgga     1200

gactgaagtt aggccagctt ggcacttgat gtaattctcc ttggaatttg ccctttttga     1260

gtttggatct tggttcattc tcaagcctca gacagtggtt caaagttttt ttcttccatt     1320

tcaggtgtcg tgagactcgt ttagtgaacc gtcagatcgc ctggagacgc catccacgct     1380

gttttgacct ccatagaaga caccgggacc gatccagcct ccgcggcccc gaattcgcca     1440

ccatgatatc ttttgctcca ttcctgtccc ccgaggcaat caagcacctc caggaaaacg     1500

aaagatgtag ggatcagtcc caaaaaagaa cggcacagca aatagaggct atctatacga     1560

gtggccagaa catacttgtt agcgcttctg cagggagcgg gaagaccttc gtcatggttg     1620

agagaattct ggacaaaatc ttgagaggcg tatccataga tcggttgttc atttctactt     1680

tcaccgtgaa ggcagccact gagcttcgag agcgcattga aaataaattg tacagccaga     1740

ttgcgcaaac aactgacttt cagatgaagg tatatctgac cgagcaactt cagtctctgt     1800

gtcaagcgga cataggcacg atggatgcat tcgcccagaa agtggtttcc cgatatggct     1860

actccatcgg aatatcctca cagtttcgaa taatgcaaga taaagcagag caagacgttt     1920

tgaagcaaga agtcttttct aagcttttta atgagtttat gaatcaaaaa gaggccccag     1980

tctttcgagc gttggttaaa aatttctctg ggaactgcaa agacacctct gcattcagag     2040

aattggtcta cacctgttat agctttagcc aatcaactga aaacccgaag atatggttgc     2100

aggaaaattt cctttccgca gcaaaaacgt accagaggct ggaagatatt ccagatcatg     2160

atattgaact cttgcttctt gcaatgcaag atacggcgaa ccaacttcgc gatgtcacgg     2220

acatggagga ctatggtcag ctcactaagg cagggagccg atcagcaaag tacactaagc     2280

accttacgat tatagagaag ctgagcgact gggttaggga ttttaaatgc ctctacggta     2340

aagctggtct ggacagattg atacgggacg ttacaggact gattcctagc ggtaacgatg     2400

ttaccgtgtc taaggtaaag taccctgtat tcaaaacctt gcaccaaaag cttaagcaat     2460

ttaggcatct ggaaacgatc ctgatgtacc aaaaagactg tttctccctg ctcgaacagt     2520

tgcaagactt tgtattggcc ttttcagagg cttacttggc tgtgaagatt caggaatctg     2580

cgttcgaatt cagtgatatt gctcacttcg cgattaaaat cctggaggaa aataccgata     2640

ttcgccagag ctatcaacag cattatcacg aagtaatggt ggacgagtat caggataata     2700

accatatgca agaacgcctc ctcacactgc tctcaaacgg tcacaacaga tttatggtgg     2760

gtgatattaa gcagtcaatc tatcgattta gacaagccga cccgcaaatt tttaaccaga     2820

agtttcggga ttatcagaaa aagcccgagc agggaaaagt catcctcctg aaagagaatt     2880

tccgctccca gagtgaagtc cttaacgtct caaatgccgt ctttagccac cttatggacg     2940

aaagtgtcgg tgatgtactg tatgacgagc agcatcagtt gattgcagga agccatgccc     3000

aaaccgtccc gtacctcgac agacgcgcgc agctcctcct gtacaattcc gataaagatg     3060

acgggaatgc accgagcgac tctgaaggca taagcttctc tgaagttaca attgtcgcta     3120

aagagatcat caagctgcac aacgataagg gagtaccttt tgaagatatt actctgctcg     3180

tgtcttcccg gaccagaaac gatattatta gccatacatt taaccagtat ggaattccaa     3240

tagctacgga tgggggtcaa cagaattatc tgaaatccgt agaggtgatg gttatgctgg     3300

acacactcag aacgataaat aatccacgga acgactacgc actcgttgca ttgttgaggt     3360

ccccgatgtt tgctttcgac gaggacgact tggcgaggat cgctttgcaa aaagataatg     3420

agctggataa ggactgtctc tatgataaaa ttcagcgagc ggtaatcggc cggggtgcac     3480

accccgagtt gatacacgat accctgcttg ggaaacttaa tgttttcctc aagacattga     3540

aatcttggcg ccggtatgcg aagctcggct ctctctatga cctcatctgg aaaattttta     3600

atgaccgctt ttactttgac ttcgtggcaa gtcaagccaa ggcagaacag gcgcaggcca     3660

acctctatgc gctcgccctt cgggctaacc aatttgaaaa gtcagggtat aaggggttgt     3720

accgcttcat aaagatgatt gataaagtcc ttgaaactca gaatgacttg gcggacgtag     3780

aagtagcgac tccgaagcag gcagttaatc tgatgacaat tcataaaagt aaaggactgc     3840

aattcccata tgtttttatc ttgaattgcg acaaacgatt tagtatgacg gatatccaca     3900

agtcatttat actgaatagg caacatggta ttggtattaa gtacttggcc gatataaaag     3960

gcttgttggg ggaaacaaca cttaatagcg ttaaggtttc catggagaca ttgccatacc     4020

aactgaacaa gcaagagctc cgactcgcca cactgagtga ggaaatgaga ctcctgtatg     4080

tggcaatgac aagagctgag aagaaggtgt actttatcgg gaaggcctca aaaagtaaaa     4140

gccaagagat tactgatccc aaaaagctgg gtaaattgct tccccttgcg ttgagagagc     4200

agctgctcac atttcaagat tggcttcttg cgattgctga catattttcc actgaagatc     4260

tgtattttga cgtgaggttc attgaagact ccgacctcac tcaagaaagc gtgggtcgat     4320

tgcagactcc tcagctcctc aaccccgacg atctgaaaga caaccggcag tccgagacaa     4380

tagcacgggc attggatatg cttgaagcgg tttcccaact taatgccaat tatgaagcgg     4440

cgatacacct cccaaccgtc agaactccct cacaacttaa ggccacctat gagccgttgc     4500

tggaacccat cggtgtcgac ataattgaga aatcatctag gtctctttcc gactttacac     4560

tcccccactt tagcaaaaag gctaaagtag aagcgtcaca cattggctca gccctccacc     4620

aactcatgca agtcctgccc ttgagtaagc caatcaacca gcagaccctc ctcgatgccc     4680

ttcgaggcat tgactcaaat gaggaagtca agacagcgtt ggatcttaaa aaaattgagt     4740

cttttttttg cgacacatca ctcggccagt ttttccagac ataccaaaag catctgtata     4800

gagaagcgcc attcgctatt ttgaaactgg atccaataag tcaagaggag tatgtcctga     4860

gagggattat cgatgcgtac tttctgtttg atgatcatat tgtacttgta gcatacaaaa     4920

cggacaaata taaacagcct atcgaactga aaaagcgcta ccaacaacag ttggaactgt     4980

acgcggaggc cctcacccaa acatataaac tccccgtcac aaagagatat ttggttctca     5040

tgggtggtgg caaacctgaa attgtagagg tcggctccgg agactataag gaccacgacg     5100

gagactacaa ggatcatgat attgattaca aagacgatga cgataagggc tccggcaaaa     5160

ggccggcggc cacgaaaaag gccggccagg caaaaaagaa aaagtgaatc tagaactata     5220

gtgagtcgta ttacgtagat ccagacatga taagatacat tgatgagttt ggacaaacca     5280

caactagaat gcagtgaaaa aaatgcttta tttgtgaaat ttgtgatgct attgctttat     5340

ttgtaaccat tataagctgc aataaacaag ttaacaacaa caattgcatt cattttatgt     5400

ttcaggttca gggggaggtg tgggaggttt tttaattcgc ggccgcggcg ccaatgcatt     5460

gggcccggta cccagctttt gttcccttta gtgagggtta attgcgcgct tggcgtaatc     5520

atggtcatag ctgtttcctg tgtgaaattg ttatccgctc acaattccac acaacatacg     5580

agccggaagc ataaagtgta aagcctgggg tgcctaatga gtgagctaac tcacattaat     5640

tgcgttgcgc tcactgcccg ctttccagtc gggaaacctg tcgtgccagc tgcattaatg     5700

aatcggccaa cgcgcgggga gaggcggttt gcgtattggg cgctcttccg cttcctcgct     5760

cactgactcg ctgcgctcgg tcgttcggct gcggcgagcg gtatcagctc actcaaaggc     5820

ggtaatacgg ttatccacag aatcagggga taacgcagga aagaacatgt gagcaaaagg     5880

ccagcaaaag gccaggaacc gtaaaaaggc cgcgttgctg gcgtttttcc ataggctccg     5940

cccccctgac gagcatcaca aaaatcgacg ctcaagtcag aggtggcgaa acccgacagg     6000

actataaaga taccaggcgt ttccccctgg aagctccctc gtgcgctctc ctgttccgac     6060

cctgccgctt accggatacc tgtccgcctt tctcccttcg ggaagcgtgg cgctttctca     6120

tagctcacgc tgtaggtatc tcagttcggt gtaggtcgtt cgctccaagc tgggctgtgt     6180

gcacgaaccc cccgttcagc ccgaccgctg cgccttatcc ggtaactatc gtcttgagtc     6240

caacccggta agacacgact tatcgccact ggcagcagcc actggtaaca ggattagcag     6300

agcgaggtat gtaggcggtg ctacagagtt cttgaagtgg tggcctaact acggctacac     6360

tagaaggaca gtatttggta tctgcgctct gctgaagcca gttaccttcg gaaaaagagt     6420

tggtagctct tgatccggca aacaaaccac cgctggtagc ggtggttttt ttgtttgcaa     6480

gcagcagatt acgcgcagaa aaaaaggatc tcaagaagat cctttgatct tttctacggg     6540

gtctgacgct cagtggaacg aaaactcacg ttaagggatt ttggtcatga gattatcaaa     6600

aaggatcttc acctagatcc ttttaaatta aaaatgaagt tttaaatcaa tctaaagtat     6660

atatgagtaa acttggtctg acagttacca atgcttaatc agtgaggcac ctatctcagc     6720

gatctgtcta tttcgttcat ccatagttgc ctgactcccc gtcgtgtaga taactacgat     6780

acgggagggc ttaccatctg gccccagtgc tgcaatgata ccgcgagacc cacgctcacc     6840

ggctccagat ttatcagcaa taaaccagcc agccggaagg gccgagcgca gaagtggtcc     6900

tgcaacttta tccgcctcca tccagtctat taattgttgc cgggaagcta gagtaagtag     6960

ttcgccagtt aatagtttgc gcaacgttgt tgccattgct acaggcatcg tggtgtcacg     7020

ctcgtcgttt ggtatggctt cattcagctc cggttcccaa cgatcaaggc gagttacatg     7080

atcccccatg ttgtgcaaaa aagcggttag ctccttcggt cctccgatcg ttgtcagaag     7140

taagttggcc gcagtgttat cactcatggt tatggcagca ctgcataatt ctcttactgt     7200

catgccatcc gtaagatgct tttctgtgac tggtgagtac tcaaccaagt cattctgaga     7260

atagtgtatg cggcgaccga gttgctcttg cccggcgtca atacgggata ataccgcgcc     7320

acatagcaga actttaaaag tgctcatcat tggaaaacgt tcttcggggc gaaaactctc     7380

aaggatctta ccgctgttga gatccagttc gatgtaaccc actcgtgcac ccaactgatc     7440

ttcagcatct tttactttca ccagcgtttc tgggtgagca aaaacaggaa ggcaaaatgc     7500

cgcaaaaaag ggaataaggg cgacacggaa atgttgaata ctcatactct tcctttttca     7560

atattattga agcatttatc agggttattg tctcatgagc ggatacatat ttgaatgtat     7620

ttagaaaaat aaacaaatag gggttccgcg cacatttccc cgaaaagtgc cacctaaatt     7680

gtaagcgtta atattttgtt aaaattcgcg ttaaattttt gttaaatcag ctcatttttt     7740

aaccaatagg ccgaaatcgg caaaatccct tataaatcaa aagaatagac cgagataggg     7800

ttgagtgttg ttccagtttg gaacaagagt ccactattaa agaacgtgga ctccaacgtc     7860

aaagggcgaa aaaccgtcta tcagggcgat ggcccactac gtgaaccatc accctaatca     7920

agttttttgg ggtcgaggtg ccgtaaagca ctaaatcgga accctaaagg gagcccccga     7980

tttagagctt gacggggaaa gccggcgaac gtggcgagaa aggaagggaa gaaagcgaaa     8040

ggagcgggcg ctagggcgct ggcaagtgta gcggtcacgc tgcgcgtaac caccacaccc     8100

gccgcgctta atgcgccgct acagggcgcg tcccattcgc cattcaggct gcgcaactgt     8160

tgggaagggc gatcggtgcg ggcctcttcg ctattacgcc ag                        8202


<210>  6
<211>  7765
<212>  DNA
<213>  artificial sequence

<220>
<223>  pCS2+_EF1a_RexB_HA_NLS plasmid

<400>  6
cctcttcgct attacgccag gtaattcata caaaaggact cgcccctgcc ttggggaatc       60

ccagggaccg tcgttaaact cccactaacg tagaacccag agatcgctgc gttcccgccc      120

cctcacccgc ccgctctcgt catcactgag gtggagaaga gcatgcgtga ggctccggtg      180

cccgtcagtg ggcagagcgc acatcgccca cagtccccga gaagttgggg ggaggggtcg      240

gcaattgaac cggtgcctag agaaggtggc gcggggtaaa ctgggaaagt gatgtcgtgt      300

actggctccg cctttttccc gagggtgggg gagaaccgta tataagtgca gtagtcgccg      360

tgaacgttct ttttcgcaac gggtttgccg ccagaacaca ggtaagtgcc gtgtgtggtt      420

cccgcgggcc tggcctcttt acgggttatg gcccttgcgt gccttgaatt acttccacgc      480

ccctggctgc agtacgtgat tcttgatccc gagcttcggg ttggaagtgg gtgggagagt      540

tcgaggcctt gcgcttaagg agccccttcg cctcgtgctt gagttgaggc ctggcttggg      600

cgctggggcc gccgcgtgcg aatctggtgg caccttcgcg cctgtctcgc tgctttcgat      660

aagtctctag ccatttaaaa tttttgatga cctgctgcga cgcttttttt ctggcaagat      720

agtcttgtaa atgcgggcca agatctgcac actggtattt cggtttttgg ggccgcgggc      780

ggcgacgggg cccgtgcgtc ccagcgcaca tgttcggcga ggcggggcct gcgagcgcgg      840

ccaccgagaa tcggacgggg gtagtctcaa gctggccggc ctgctctggt gcctggcctc      900

gcgccgccgt gtatcgcccc gccctgggcg gcaaggctgg cccggtcggc accagttgcg      960

tgagcggaaa gatggccgct tcccggccct gctgcaggga gctcaaaatg gaggacgcgg     1020

cgctcgggag agcgggcggg tgagtcaccc acacaaagga aaagggcctt tccgtcctca     1080

gccgtcgctt catgtgactc cacggagtac cgggcgccgt ccaggcacct cgattagttc     1140

tcgagctttt ggagtacgtc gtctttaggt tggggggagg ggttttatgc gatggagttt     1200

ccccacactg agtgggtgga gactgaagtt aggccagctt ggcacttgat gtaattctcc     1260

ttggaatttg ccctttttga gtttggatct tggttcattc tcaagcctca gacagtggtt     1320

caaagttttt ttcttccatt tcaggtgtcg tgagactcgt ttagtgaacc gtcagatcgc     1380

ctggagacgc catccacgct gttttgacct ccatagaaga caccgggacc gatccagcct     1440

ccgcggcccc gaattcgcca ccatgaagct gatttataca gagatgagtt acagcatgac     1500

ggaaatactc gtcaatgaag caagaaaggc ggctgaccaa ggctacaggg tattctacat     1560

tgcacctaac agtctgagtt ttgaaaagga aagggaggtt ttgaccctcc tgcccgaacg     1620

cggaacgttc agcataattg taaccaggtt tgtacaaatg agtaggtact ttactgtgga     1680

atcatcacca tctaaacagc acctggatga taccacgctt gcaatgatat tctatagagc     1740

actgatgcaa ttgaaacctg aagatctccc gtcatatggt cgactgcaaa acaattcagt     1800

tttcattgag caattggtag agctttataa agagcttaaa aatgctcaac tgagtgtaca     1860

cgatttgacg ggccttgacc acccgcaaaa acaggaggac ctcattaaaa taatagagtt     1920

ggctgaaacc ataatgatac agcaggatta caaccaggat tctccgctcc aaagttttgc     1980

ccgagccatt aagctgggct tgctgaacaa tcagctctca aagacggtgg tcgtgataga     2040

cggattttct aggttcagcg ctgaagaaga ttaccttctt agccttctga acaacaattg     2100

ccaggaggta ataatcggct catatgttag tcagaaggcc tatcaaaagt cattcataaa     2160

ggggaatatt tacgaagcct ctttgcactt tcttcaggat ctcgcccaga agtatcacat     2220

caagccagtc tttgcgacta gtaaccaggt ttttaagcct gcattttccc ggctcaccca     2280

gttgtttgag gcgacccatg atttttctca ggtggattgg caattgcaga aaagtgatct     2340

ggaccacttt tcactgtggc aatgccatca tcaaaaagag gaaattgagc acgtcgcaaa     2400

gtcaatccga caaaaattgt acgaaggtta tcgctataaa gacatactcg tcttgcttgg     2460

ggatatggac gcttatcagc tccagatcgg cccgatcttc gataagttcg agatacccta     2520

ttacctcggc aaagctgagc ccatggcggc tcaccctttg gtgcagttta tagagagtct     2580

cgagaggtca caacgatata actggcgccg agaggatatt ctcaacatgt tgaagagcgg     2640

gctcttcggc tgtttcgacg acagcgacat tgaccgattt gaagagtata ctcaattcgc     2700

agatataaaa ggcttcacaa aattcagtaa accctttaca atcaacagca gccgacaata     2760

tcccctcgat ttcttgaacg aaatgcgaca ggatatagtg ttgcccctcc aggaattgtt     2820

taaaagccag aagcagctcg gggcatcact cgtagataag ttgattctgt ttttgaagaa     2880

gattcgattg gctgaaaaca tgcaaggctt ggcacagtcc caacttgagg tggagaaaaa     2940

cgaagaggtc tggaaaagat ttactgacat actcacgtct ttccaccata tttttgggca     3000

ggaaaaactc cgattgtctg actgcttggc tctgattaaa acagggatga aaagtgcgca     3060

ataccgcgtt gtgcctgcga ctcttgatgt cgttacaata aaatcctatg atctcgtaca     3120

accacattcc aaaccgtttg tatacgcgat aggcttgacg caaagtcact tccctaaaca     3180

aatacatcat agcggtcttt tgtccgacca agagagagcc cgaatcaatg aaatcaggaa     3240

ctaccggcat tttgacatag ctagcgcgga gaattctaaa aagaaccatc agaccgcact     3300

gagcttgttc aacgcagcca ctaaagaact ggttcttagc gtgtcaacag ttattaatga     3360

aacatttgat gatctctcac cttatcttaa ggaactcatt aacttcgggc tcccgctcct     3420

ggacaaggga aaaaactatc tctcttatga taactctgac atagggaact acaaggcgct     3480

tttgtcacag attattgcca ttaatcgaca ggaccttatc gaaatgagtg accaagataa     3540

aatgttttgg acggtagtgc tccgctatct tcggaagcag ttgcggaaac agcaactgga     3600

gctgccaact tccgattaca gactcagcac taagcccttg agcaaagaag tcatcgaagt     3660

ctgttttccc aaggggatac cgcttaagct ttcagcaacg gctttgactg tgttttacaa     3720

caatcaatat aactatttct tgaaatacgt tctcaacctg aataagaccg agtctataca     3780

tccagacagc agaatacatg gacagtacct tcatagggta ttcgaacgac tgatgaagga     3840

ccacacgcaa gaaccattcg ataacaagct caagcaagcc atttatcaca cgaaccagga     3900

gagcttcttc cagcaagtat accaagacaa cgcggaggcc gaatactctt tggcaatttt     3960

ggaggacatc gtacgctcca ccgcacctat cctgcaactg aaccagaata ttcaagtaat     4020

agaccaagag aaaaattttc agttggatat gggtaacgaa attctggtac acggaattat     4080

tgatcgcatt gatcagctgt ccgacggatc tcttggcatt gtagactaca aatcctctgc     4140

gaaccaattt gacatcggta cgttttacaa cgggctgagc ccacaattga tgacatacct     4200

cgcagccctg aagcagatag caccccacga tatcaaccaa ttgttcggcg cgatgtatct     4260

ccacttgcag gacccgaaac ttgaccttgt aacctttaaa cagatcgata acacattggt     4320

tgagtctatt tacaaggctc tcacttacaa agggatattt agtgaagtag agaaagagca     4380

tctttctaca ggcgcatacc agacgaagaa tgcgttgtat agcaacgatg agcttgagac     4440

tttgctcaat tacaacaagt acctttacct caaagcagcc aagcatataa agaaggggca     4500

tttcctcatc aatccgtaca cgtctgatgg caaaacagtt caaggcgacc aactcaaagc     4560

tatcacccgc ttcgaagccg acttggacat ggggcaggct cggagactgg tgacactgcc     4620

tgctaaagag aaaaaagagt gcttcctgac cctcatgagg aaggagtccc atcttggctc     4680

cggataccca tacgatgttc cagattacgc tggctccggc aaaaggccgg cggccacgaa     4740

aaaggccggc caggcaaaaa agaaaaagta gtctagaact atagtgagtc gtattacgta     4800

gatccagaca tgataagata cattgatgag tttggacaaa ccacaactag aatgcagtga     4860

aaaaaatgct ttatttgtga aatttgtgat gctattgctt tatttgtaac cattataagc     4920

tgcaataaac aagttaacaa caacaattgc attcatttta tgtttcaggt tcagggggag     4980

gtgtgggagg ttttttaatt cgcggccgcg gcgccaatgc attgggcccg gtacccagct     5040

tttgttccct ttagtgaggg ttaattgcgc gcttggcgta atcatggtca tagctgtttc     5100

ctgtgtgaaa ttgttatccg ctcacaattc cacacaacat acgagccgga agcataaagt     5160

gtaaagcctg gggtgcctaa tgagtgagct aactcacatt aattgcgttg cgctcactgc     5220

ccgctttcca gtcgggaaac ctgtcgtgcc agctgcatta atgaatcggc caacgcgcgg     5280

ggagaggcgg tttgcgtatt gggcgctctt ccgcttcctc gctcactgac tcgctgcgct     5340

cggtcgttcg gctgcggcga gcggtatcag ctcactcaaa ggcggtaata cggttatcca     5400

cagaatcagg ggataacgca ggaaagaaca tgtgagcaaa aggccagcaa aaggccagga     5460

accgtaaaaa ggccgcgttg ctggcgtttt tccataggct ccgcccccct gacgagcatc     5520

acaaaaatcg acgctcaagt cagaggtggc gaaacccgac aggactataa agataccagg     5580

cgtttccccc tggaagctcc ctcgtgcgct ctcctgttcc gaccctgccg cttaccggat     5640

acctgtccgc ctttctccct tcgggaagcg tggcgctttc tcatagctca cgctgtaggt     5700

atctcagttc ggtgtaggtc gttcgctcca agctgggctg tgtgcacgaa ccccccgttc     5760

agcccgaccg ctgcgcctta tccggtaact atcgtcttga gtccaacccg gtaagacacg     5820

acttatcgcc actggcagca gccactggta acaggattag cagagcgagg tatgtaggcg     5880

gtgctacaga gttcttgaag tggtggccta actacggcta cactagaagg acagtatttg     5940

gtatctgcgc tctgctgaag ccagttacct tcggaaaaag agttggtagc tcttgatccg     6000

gcaaacaaac caccgctggt agcggtggtt tttttgtttg caagcagcag attacgcgca     6060

gaaaaaaagg atctcaagaa gatcctttga tcttttctac ggggtctgac gctcagtgga     6120

acgaaaactc acgttaaggg attttggtca tgagattatc aaaaaggatc ttcacctaga     6180

tccttttaaa ttaaaaatga agttttaaat caatctaaag tatatatgag taaacttggt     6240

ctgacagtta ccaatgctta atcagtgagg cacctatctc agcgatctgt ctatttcgtt     6300

catccatagt tgcctgactc cccgtcgtgt agataactac gatacgggag ggcttaccat     6360

ctggccccag tgctgcaatg ataccgcgag acccacgctc accggctcca gatttatcag     6420

caataaacca gccagccgga agggccgagc gcagaagtgg tcctgcaact ttatccgcct     6480

ccatccagtc tattaattgt tgccgggaag ctagagtaag tagttcgcca gttaatagtt     6540

tgcgcaacgt tgttgccatt gctacaggca tcgtggtgtc acgctcgtcg tttggtatgg     6600

cttcattcag ctccggttcc caacgatcaa ggcgagttac atgatccccc atgttgtgca     6660

aaaaagcggt tagctccttc ggtcctccga tcgttgtcag aagtaagttg gccgcagtgt     6720

tatcactcat ggttatggca gcactgcata attctcttac tgtcatgcca tccgtaagat     6780

gcttttctgt gactggtgag tactcaacca agtcattctg agaatagtgt atgcggcgac     6840

cgagttgctc ttgcccggcg tcaatacggg ataataccgc gccacatagc agaactttaa     6900

aagtgctcat cattggaaaa cgttcttcgg ggcgaaaact ctcaaggatc ttaccgctgt     6960

tgagatccag ttcgatgtaa cccactcgtg cacccaactg atcttcagca tcttttactt     7020

tcaccagcgt ttctgggtga gcaaaaacag gaaggcaaaa tgccgcaaaa aagggaataa     7080

gggcgacacg gaaatgttga atactcatac tcttcctttt tcaatattat tgaagcattt     7140

atcagggtta ttgtctcatg agcggataca tatttgaatg tatttagaaa aataaacaaa     7200

taggggttcc gcgcacattt ccccgaaaag tgccacctaa attgtaagcg ttaatatttt     7260

gttaaaattc gcgttaaatt tttgttaaat cagctcattt tttaaccaat aggccgaaat     7320

cggcaaaatc ccttataaat caaaagaata gaccgagata gggttgagtg ttgttccagt     7380

ttggaacaag agtccactat taaagaacgt ggactccaac gtcaaagggc gaaaaaccgt     7440

ctatcagggc gatggcccac tacgtgaacc atcaccctaa tcaagttttt tggggtcgag     7500

gtgccgtaaa gcactaaatc ggaaccctaa agggagcccc cgatttagag cttgacgggg     7560

aaagccggcg aacgtggcga gaaaggaagg gaagaaagcg aaaggagcgg gcgctagggc     7620

gctggcaagt gtagcggtca cgctgcgcgt aaccaccaca cccgccgcgc ttaatgcgcc     7680

gctacagggc gcgtcccatt cgccattcag gctgcgcaac tgttgggaag ggcgatcggt     7740

gcgggcctct tcgctattac gccag                                           7765


<210>  7
<211>  7765
<212>  DNA
<213>  artificial sequence

<220>
<223>  pCS2+_EF1a_RexB_ND_HA_NLS plasmid

<400>  7
cctcttcgct attacgccag gtaattcata caaaaggact cgcccctgcc ttggggaatc       60

ccagggaccg tcgttaaact cccactaacg tagaacccag agatcgctgc gttcccgccc      120

cctcacccgc ccgctctcgt catcactgag gtggagaaga gcatgcgtga ggctccggtg      180

cccgtcagtg ggcagagcgc acatcgccca cagtccccga gaagttgggg ggaggggtcg      240

gcaattgaac cggtgcctag agaaggtggc gcggggtaaa ctgggaaagt gatgtcgtgt      300

actggctccg cctttttccc gagggtgggg gagaaccgta tataagtgca gtagtcgccg      360

tgaacgttct ttttcgcaac gggtttgccg ccagaacaca ggtaagtgcc gtgtgtggtt      420

cccgcgggcc tggcctcttt acgggttatg gcccttgcgt gccttgaatt acttccacgc      480

ccctggctgc agtacgtgat tcttgatccc gagcttcggg ttggaagtgg gtgggagagt      540

tcgaggcctt gcgcttaagg agccccttcg cctcgtgctt gagttgaggc ctggcttggg      600

cgctggggcc gccgcgtgcg aatctggtgg caccttcgcg cctgtctcgc tgctttcgat      660

aagtctctag ccatttaaaa tttttgatga cctgctgcga cgcttttttt ctggcaagat      720

agtcttgtaa atgcgggcca agatctgcac actggtattt cggtttttgg ggccgcgggc      780

ggcgacgggg cccgtgcgtc ccagcgcaca tgttcggcga ggcggggcct gcgagcgcgg      840

ccaccgagaa tcggacgggg gtagtctcaa gctggccggc ctgctctggt gcctggcctc      900

gcgccgccgt gtatcgcccc gccctgggcg gcaaggctgg cccggtcggc accagttgcg      960

tgagcggaaa gatggccgct tcccggccct gctgcaggga gctcaaaatg gaggacgcgg     1020

cgctcgggag agcgggcggg tgagtcaccc acacaaagga aaagggcctt tccgtcctca     1080

gccgtcgctt catgtgactc cacggagtac cgggcgccgt ccaggcacct cgattagttc     1140

tcgagctttt ggagtacgtc gtctttaggt tggggggagg ggttttatgc gatggagttt     1200

ccccacactg agtgggtgga gactgaagtt aggccagctt ggcacttgat gtaattctcc     1260

ttggaatttg ccctttttga gtttggatct tggttcattc tcaagcctca gacagtggtt     1320

caaagttttt ttcttccatt tcaggtgtcg tgagactcgt ttagtgaacc gtcagatcgc     1380

ctggagacgc catccacgct gttttgacct ccatagaaga caccgggacc gatccagcct     1440

ccgcggcccc gaattcgcca ccatgaagct gatttataca gagatgagtt acagcatgac     1500

ggaaatactc gtcaatgaag caagaaaggc ggctgaccaa ggctacaggg tattctacat     1560

tgcacctaac agtctgagtt ttgaaaagga aagggaggtt ttgaccctcc tgcccgaacg     1620

cggaacgttc agcataattg taaccaggtt tgtacaaatg agtaggtact ttactgtgga     1680

atcatcacca tctaaacagc acctggatga taccacgctt gcaatgatat tctatagagc     1740

actgatgcaa ttgaaacctg aagatctccc gtcatatggt cgactgcaaa acaattcagt     1800

tttcattgag caattggtag agctttataa agagcttaaa aatgctcaac tgagtgtaca     1860

cgatttgacg ggccttgacc acccgcaaaa acaggaggac ctcattaaaa taatagagtt     1920

ggctgaaacc ataatgatac agcaggatta caaccaggat tctccgctcc aaagttttgc     1980

ccgagccatt aagctgggct tgctgaacaa tcagctctca aagacggtgg tcgtgataga     2040

cggattttct aggttcagcg ctgaagaaga ttaccttctt agccttctga acaacaattg     2100

ccaggaggta ataatcggct catatgttag tcagaaggcc tatcaaaagt cattcataaa     2160

ggggaatatt tacgaagcct ctttgcactt tcttcaggat ctcgcccaga agtatcacat     2220

caagccagtc tttgcgacta gtaaccaggt ttttaagcct gcattttccc ggctcaccca     2280

gttgtttgag gcgacccatg atttttctca ggtggattgg caattgcaga aaagtgatct     2340

ggaccacttt tcactgtggc aatgccatca tcaaaaagag gaaattgagc acgtcgcaaa     2400

gtcaatccga caaaaattgt acgaaggtta tcgctataaa gacatactcg tcttgcttgg     2460

ggatatggac gcttatcagc tccagatcgg cccgatcttc gataagttcg agatacccta     2520

ttacctcggc aaagctgagc ccatggcggc tcaccctttg gtgcagttta tagagagtct     2580

cgagaggtca caacgatata actggcgccg agaggatatt ctcaacatgt tgaagagcgg     2640

gctcttcggc tgtttcgacg acagcgacat tgaccgattt gaagagtata ctcaattcgc     2700

agatataaaa ggcttcacaa aattcagtaa accctttaca atcaacagca gccgacaata     2760

tcccctcgat ttcttgaacg aaatgcgaca ggatatagtg ttgcccctcc aggaattgtt     2820

taaaagccag aagcagctcg gggcatcact cgtagataag ttgattctgt ttttgaagaa     2880

gattcgattg gctgaaaaca tgcaaggctt ggcacagtcc caacttgagg tggagaaaaa     2940

cgaagaggtc tggaaaagat ttactgacat actcacgtct ttccaccata tttttgggca     3000

ggaaaaactc cgattgtctg actgcttggc tctgattaaa acagggatga aaagtgcgca     3060

ataccgcgtt gtgcctgcga ctcttgatgt cgttacaata aaatcctatg atctcgtaca     3120

accacattcc aaaccgtttg tatacgcgat aggcttgacg caaagtcact tccctaaaca     3180

aatacatcat agcggtcttt tgtccgacca agagagagcc cgaatcaatg aaatcaggaa     3240

ctaccggcat tttgacatag ctagcgcgga gaattctaaa aagaaccatc agaccgcact     3300

gagcttgttc aacgcagcca ctaaagaact ggttcttagc gtgtcaacag ttattaatga     3360

aacatttgat gatctctcac cttatcttaa ggaactcatt aacttcgggc tcccgctcct     3420

ggacaaggga aaaaactatc tctcttatga taactctgac atagggaact acaaggcgct     3480

tttgtcacag attattgcca ttaatcgaca ggaccttatc gaaatgagtg accaagataa     3540

aatgttttgg acggtagtgc tccgctatct tcggaagcag ttgcggaaac agcaactgga     3600

gctgccaact tccgattaca gactcagcac taagcccttg agcaaagaag tcatcgaagt     3660

ctgttttccc aaggggatac cgcttaagct ttcagcaacg gctttgactg tgttttacaa     3720

caatcaatat aactatttct tgaaatacgt tctcaacctg aataagaccg agtctataca     3780

tccagacagc agaatacatg gacagtacct tcatagggta ttcgaacgac tgatgaagga     3840

ccacacgcaa gaaccattcg ataacaagct caagcaagcc atttatcaca cgaaccagga     3900

gagcttcttc cagcaagtat accaagacaa cgcggaggcc gaatactctt tggcaatttt     3960

ggaggacatc gtacgctcca ccgcacctat cctgcaactg aaccagaata ttcaagtaat     4020

agaccaagag aaaaattttc agttggatat gggtaacgaa attctggtac acggaattat     4080

tgatcgcatt gatcagctgt ccgacggatc tcttggcatt gtagcataca aatcctctgc     4140

gaaccaattt gacatcggta cgttttacaa cgggctgagc ccacaattga tgacatacct     4200

cgcagccctg aagcagatag caccccacga tatcaaccaa ttgttcggcg cgatgtatct     4260

ccacttgcag gacccgaaac ttgaccttgt aacctttaaa cagatcgata acacattggt     4320

tgagtctatt tacaaggctc tcacttacaa agggatattt agtgaagtag agaaagagca     4380

tctttctaca ggcgcatacc agacgaagaa tgcgttgtat agcaacgatg agcttgagac     4440

tttgctcaat tacaacaagt acctttacct caaagcagcc aagcatataa agaaggggca     4500

tttcctcatc aatccgtaca cgtctgatgg caaaacagtt caaggcgacc aactcaaagc     4560

tatcacccgc ttcgaagccg acttggacat ggggcaggct cggagactgg tgacactgcc     4620

tgctaaagag aaaaaagagt gcttcctgac cctcatgagg aaggagtccc atcttggctc     4680

cggataccca tacgatgttc cagattacgc tggctccggc aaaaggccgg cggccacgaa     4740

aaaggccggc caggcaaaaa agaaaaagta gtctagaact atagtgagtc gtattacgta     4800

gatccagaca tgataagata cattgatgag tttggacaaa ccacaactag aatgcagtga     4860

aaaaaatgct ttatttgtga aatttgtgat gctattgctt tatttgtaac cattataagc     4920

tgcaataaac aagttaacaa caacaattgc attcatttta tgtttcaggt tcagggggag     4980

gtgtgggagg ttttttaatt cgcggccgcg gcgccaatgc attgggcccg gtacccagct     5040

tttgttccct ttagtgaggg ttaattgcgc gcttggcgta atcatggtca tagctgtttc     5100

ctgtgtgaaa ttgttatccg ctcacaattc cacacaacat acgagccgga agcataaagt     5160

gtaaagcctg gggtgcctaa tgagtgagct aactcacatt aattgcgttg cgctcactgc     5220

ccgctttcca gtcgggaaac ctgtcgtgcc agctgcatta atgaatcggc caacgcgcgg     5280

ggagaggcgg tttgcgtatt gggcgctctt ccgcttcctc gctcactgac tcgctgcgct     5340

cggtcgttcg gctgcggcga gcggtatcag ctcactcaaa ggcggtaata cggttatcca     5400

cagaatcagg ggataacgca ggaaagaaca tgtgagcaaa aggccagcaa aaggccagga     5460

accgtaaaaa ggccgcgttg ctggcgtttt tccataggct ccgcccccct gacgagcatc     5520

acaaaaatcg acgctcaagt cagaggtggc gaaacccgac aggactataa agataccagg     5580

cgtttccccc tggaagctcc ctcgtgcgct ctcctgttcc gaccctgccg cttaccggat     5640

acctgtccgc ctttctccct tcgggaagcg tggcgctttc tcatagctca cgctgtaggt     5700

atctcagttc ggtgtaggtc gttcgctcca agctgggctg tgtgcacgaa ccccccgttc     5760

agcccgaccg ctgcgcctta tccggtaact atcgtcttga gtccaacccg gtaagacacg     5820

acttatcgcc actggcagca gccactggta acaggattag cagagcgagg tatgtaggcg     5880

gtgctacaga gttcttgaag tggtggccta actacggcta cactagaagg acagtatttg     5940

gtatctgcgc tctgctgaag ccagttacct tcggaaaaag agttggtagc tcttgatccg     6000

gcaaacaaac caccgctggt agcggtggtt tttttgtttg caagcagcag attacgcgca     6060

gaaaaaaagg atctcaagaa gatcctttga tcttttctac ggggtctgac gctcagtgga     6120

acgaaaactc acgttaaggg attttggtca tgagattatc aaaaaggatc ttcacctaga     6180

tccttttaaa ttaaaaatga agttttaaat caatctaaag tatatatgag taaacttggt     6240

ctgacagtta ccaatgctta atcagtgagg cacctatctc agcgatctgt ctatttcgtt     6300

catccatagt tgcctgactc cccgtcgtgt agataactac gatacgggag ggcttaccat     6360

ctggccccag tgctgcaatg ataccgcgag acccacgctc accggctcca gatttatcag     6420

caataaacca gccagccgga agggccgagc gcagaagtgg tcctgcaact ttatccgcct     6480

ccatccagtc tattaattgt tgccgggaag ctagagtaag tagttcgcca gttaatagtt     6540

tgcgcaacgt tgttgccatt gctacaggca tcgtggtgtc acgctcgtcg tttggtatgg     6600

cttcattcag ctccggttcc caacgatcaa ggcgagttac atgatccccc atgttgtgca     6660

aaaaagcggt tagctccttc ggtcctccga tcgttgtcag aagtaagttg gccgcagtgt     6720

tatcactcat ggttatggca gcactgcata attctcttac tgtcatgcca tccgtaagat     6780

gcttttctgt gactggtgag tactcaacca agtcattctg agaatagtgt atgcggcgac     6840

cgagttgctc ttgcccggcg tcaatacggg ataataccgc gccacatagc agaactttaa     6900

aagtgctcat cattggaaaa cgttcttcgg ggcgaaaact ctcaaggatc ttaccgctgt     6960

tgagatccag ttcgatgtaa cccactcgtg cacccaactg atcttcagca tcttttactt     7020

tcaccagcgt ttctgggtga gcaaaaacag gaaggcaaaa tgccgcaaaa aagggaataa     7080

gggcgacacg gaaatgttga atactcatac tcttcctttt tcaatattat tgaagcattt     7140

atcagggtta ttgtctcatg agcggataca tatttgaatg tatttagaaa aataaacaaa     7200

taggggttcc gcgcacattt ccccgaaaag tgccacctaa attgtaagcg ttaatatttt     7260

gttaaaattc gcgttaaatt tttgttaaat cagctcattt tttaaccaat aggccgaaat     7320

cggcaaaatc ccttataaat caaaagaata gaccgagata gggttgagtg ttgttccagt     7380

ttggaacaag agtccactat taaagaacgt ggactccaac gtcaaagggc gaaaaaccgt     7440

ctatcagggc gatggcccac tacgtgaacc atcaccctaa tcaagttttt tggggtcgag     7500

gtgccgtaaa gcactaaatc ggaaccctaa agggagcccc cgatttagag cttgacgggg     7560

aaagccggcg aacgtggcga gaaaggaagg gaagaaagcg aaaggagcgg gcgctagggc     7620

gctggcaagt gtagcggtca cgctgcgcgt aaccaccaca cccgccgcgc ttaatgcgcc     7680

gctacagggc gcgtcccatt cgccattcag gctgcgcaac tgttgggaag ggcgatcggt     7740

gcgggcctct tcgctattac gccag                                           7765


<210>  8
<211>  3477
<212>  DNA
<213>  S. aureus

<400>  8
atgacattac atgcttattt aggtagagcg ggaacaggta agtctacgaa aatgttgacc       60

gaaataaaac aaaaaatgaa agcagatccg cttggagatc caatcatttt aattgcgcca      120

actcaaagta catttcaatt agaacaagcc tttgtcaatg atccggaatt aaatggtagt      180

ttaagaacag aagtgttgca ttttgaacga ttaagtcatc gtattttcca agaagttggt      240

agttatagcg aacaaaagtt atctaaagct gcaacggaaa tgatgattta taacattgtt      300

caagaacaac aaaagtattt aaaactttat caatcacaag caaaatatta tgggtttagt      360

gaaaaattaa cagaacaaat tcaagatttt aaaaaatatg cagtaacgcc tgaacattta      420

gaacacttta ttgctgataa aaatatgcaa actcgaacta aaaataagtt agaggatatt      480

gctttaatat accgtgagtt cgaacaacgc attcaaaacg agtttattac gggtgaggat      540

tcattacaat attttattga ttgtatgccg aaatcagagt ggctaaaacg tgctgatata      600

tatattgatg gttttcacaa cttttcaacg attgagtatt taataatcaa aggattaatt      660

aaatatgcga agagtgtcac aattatattg acgacagatg gtaaccacga tcaatttagt      720

ttatttagaa aaccatcgga agtgttacga catattgaag aaatagcaaa tgaactcaat      780

atttctattg aacgtcaata tttcaaccaa ttatatcgct tcaataatca agatttaaag      840

catcttgaac aagaatttga tgcacttcaa atcaatcgag tggcatgtca aggtcatatc      900

aatattttag aatctgcgac tatgagagag gaaataaatg aaattgcgcg acgtatcatc      960

gttgatattc gtgataagca attacgatat caagatattg ctattttata tcgtgatgaa     1020

tcttatgctt atttatttga ttccatatta ccgctttata atattcctta taatattgat     1080

acaaagcgtt cgatgacaca tcatccggtc atggaaatga ttcgttcatt gattgaagtt     1140

attcaatcta attggcaagt gaatccaatg ctacgcttat tgaagactga tgtgttaacg     1200

gcatcatatc taaaaagtgc atacttagtt gatttacttg aaaattttgt acttgaacgt     1260

ggtatatacg gtaaacgttg gttagatgat gagctattta atgtcgaaca ttttagcaaa     1320

atggggcgta aagcgcataa actgaccgaa gatgaacgta acacatttga acaagtcgtt     1380

aagttaaaga aagatgtcat tgataaaatt ttacattttg aaaagcaaat gtcacaagcg     1440

gaaactgtaa aagattttgc aactgctttt tatgaaagta tggaatattt cgaactgcca     1500

aatcaattga tgacagagcg agatgaactt gatttaaatg gtaatcatga aaaggcggag     1560

gaaattgatc aaatatggaa tggcttaatt caaatccttg atgacttagt tctagtattt     1620

ggagatgaac caatgtcgat ggaacgtttc ttagaagtat ttgatattgg tttagaacaa     1680

ttagaatttg ttatgattcc gcaaacattg gaccaagtaa gtattggtac gatggatttg     1740

gctaaagtcg ataataagca acatgtttac ttagtaggta tgaatgatgg aacgatgcca     1800

caaccagtaa ctgcgtcaag cttgattaca gatgaagaaa agaaatactt tgaacagcag     1860

gctaatgtcg agttaagtcc aacatcagat attttacaga tggatgaagc atttgtttgt     1920

tatgttgcta tgactagagc taagggagat gttacatttt cttacagtct aatgggatca     1980

agtggtgatg ataaggagat cagcccattt ttaaatcaaa ttcaatcatt gttcaaccaa     2040

ttggaaatta ctaacattcc tcaataccat gaagttaacc cattgtcact aatgcaacat     2100

gctaagcaaa ccaaaattac attatttgaa gcattgcgtg cttggttata tgatgaaatt     2160

gtggctgata gttggttaga tgcttatcaa gtaattagag atagcgatca tttaaatcaa     2220

ggtttagatt atttaatgtc agcattaacg tttgacaatg aaactgtaaa attaggtgaa     2280

acgttgtcta aagatttata tggtaaggaa atcaatgcca gtgtatcccg ttttgaaggt     2340

tatcaacaat gcccatttaa acactatgcg tcacatggtc tgaaactaaa tgagcgaacg     2400

aagtatgaac ttcaaaactt tgatttaggt gatattttcc attctgtttt aaaatatata     2460

tctgaacgta ttaatggcga ttttaaacaa ttagacctga aaaaaataag acaattaacg     2520

aatgaagcat tggaagaaat tttacctaaa gttcagttta atttattaaa ttcttcagct     2580

tactatcgtt atttatcaag acgcattggc gctattgtag aaacaacact aagcgcatta     2640

aaatatcaag gcacgtattc aaagtttatg ccaaaacatt ttgagacaag ttttagaagg     2700

aaaccaagaa caaatgacga attaattgca caaacattaa cgacaactca aggtattcca     2760

attaatatta gagggcaaat tgaccgtatc gatacgtata caaagaatga tacaagtttt     2820

gttaatatca ttgactataa atcctctgaa ggtagtgcga cacttgattt aacgaaagta     2880

tattatggta tgcaaatgca aatgatgaca tacatggata tcgttttaca aaataaacaa     2940

cgccttggat taacagatat tgtgaaacca ggtggattat tatacttcca tgtacatgaa     3000

cctagaatta aatttaaatc atggtctgat attgatgaag ataaactaga acaagattta     3060

attaaaaagt ttaagttgag tggtttagtt aatgcagacc aaactgttat tgatgcattg     3120

gatattcgtt tagaacctaa attcacttca gatattgtac cagttggttt gaataaagat     3180

ggctctttga gtaaacgagg cagccaagtg gcagatgaag caacgattta taaattcatc     3240

caacataaca aagagaattt tatagaaaca gcttcaaata ttatggatgg acatactgaa     3300

gttgcaccat taaagtacaa acaaaaattg ccatgtgctt tttgtagtta tcaatcggta     3360

tgtcatgtag atggcatgat tgatagtaag cgatatcgaa ctgtagatga aacaataaat     3420

ccaattgaag caattcaaaa tattaacatt aatgatgaat ttgggggtga gcaatag        3477


<210>  9
<211>  1158
<212>  PRT
<213>  S. aureus

<400>  9

Met Thr Leu His Ala Tyr Leu Gly Arg Ala Gly Thr Gly Lys Ser Thr 
1               5                   10                  15      


Lys Met Leu Thr Glu Ile Lys Gln Lys Met Lys Ala Asp Pro Leu Gly 
            20                  25                  30          


Asp Pro Ile Ile Leu Ile Ala Pro Thr Gln Ser Thr Phe Gln Leu Glu 
        35                  40                  45              


Gln Ala Phe Val Asn Asp Pro Glu Leu Asn Gly Ser Leu Arg Thr Glu 
    50                  55                  60                  


Val Leu His Phe Glu Arg Leu Ser His Arg Ile Phe Gln Glu Val Gly 
65                  70                  75                  80  


Ser Tyr Ser Glu Gln Lys Leu Ser Lys Ala Ala Thr Glu Met Met Ile 
                85                  90                  95      


Tyr Asn Ile Val Gln Glu Gln Gln Lys Tyr Leu Lys Leu Tyr Gln Ser 
            100                 105                 110         


Gln Ala Lys Tyr Tyr Gly Phe Ser Glu Lys Leu Thr Glu Gln Ile Gln 
        115                 120                 125             


Asp Phe Lys Lys Tyr Ala Val Thr Pro Glu His Leu Glu His Phe Ile 
    130                 135                 140                 


Ala Asp Lys Asn Met Gln Thr Arg Thr Lys Asn Lys Leu Glu Asp Ile 
145                 150                 155                 160 


Ala Leu Ile Tyr Arg Glu Phe Glu Gln Arg Ile Gln Asn Glu Phe Ile 
                165                 170                 175     


Thr Gly Glu Asp Ser Leu Gln Tyr Phe Ile Asp Cys Met Pro Lys Ser 
            180                 185                 190         


Glu Trp Leu Lys Arg Ala Asp Ile Tyr Ile Asp Gly Phe His Asn Phe 
        195                 200                 205             


Ser Thr Ile Glu Tyr Leu Ile Ile Lys Gly Leu Ile Lys Tyr Ala Lys 
    210                 215                 220                 


Ser Val Thr Ile Ile Leu Thr Thr Asp Gly Asn His Asp Gln Phe Ser 
225                 230                 235                 240 


Leu Phe Arg Lys Pro Ser Glu Val Leu Arg His Ile Glu Glu Ile Ala 
                245                 250                 255     


Asn Glu Leu Asn Ile Ser Ile Glu Arg Gln Tyr Phe Asn Gln Leu Tyr 
            260                 265                 270         


Arg Phe Asn Asn Gln Asp Leu Lys His Leu Glu Gln Glu Phe Asp Ala 
        275                 280                 285             


Leu Gln Ile Asn Arg Val Ala Cys Gln Gly His Ile Asn Ile Leu Glu 
    290                 295                 300                 


Ser Ala Thr Met Arg Glu Glu Ile Asn Glu Ile Ala Arg Arg Ile Ile 
305                 310                 315                 320 


Val Asp Ile Arg Asp Lys Gln Leu Arg Tyr Gln Asp Ile Ala Ile Leu 
                325                 330                 335     


Tyr Arg Asp Glu Ser Tyr Ala Tyr Leu Phe Asp Ser Ile Leu Pro Leu 
            340                 345                 350         


Tyr Asn Ile Pro Tyr Asn Ile Asp Thr Lys Arg Ser Met Thr His His 
        355                 360                 365             


Pro Val Met Glu Met Ile Arg Ser Leu Ile Glu Val Ile Gln Ser Asn 
    370                 375                 380                 


Trp Gln Val Asn Pro Met Leu Arg Leu Leu Lys Thr Asp Val Leu Thr 
385                 390                 395                 400 


Ala Ser Tyr Leu Lys Ser Ala Tyr Leu Val Asp Leu Leu Glu Asn Phe 
                405                 410                 415     


Val Leu Glu Arg Gly Ile Tyr Gly Lys Arg Trp Leu Asp Asp Glu Leu 
            420                 425                 430         


Phe Asn Val Glu His Phe Ser Lys Met Gly Arg Lys Ala His Lys Leu 
        435                 440                 445             


Thr Glu Asp Glu Arg Asn Thr Phe Glu Gln Val Val Lys Leu Lys Lys 
    450                 455                 460                 


Asp Val Ile Asp Lys Ile Leu His Phe Glu Lys Gln Met Ser Gln Ala 
465                 470                 475                 480 


Glu Thr Val Lys Asp Phe Ala Thr Ala Phe Tyr Glu Ser Met Glu Tyr 
                485                 490                 495     


Phe Glu Leu Pro Asn Gln Leu Met Thr Glu Arg Asp Glu Leu Asp Leu 
            500                 505                 510         


Asn Gly Asn His Glu Lys Ala Glu Glu Ile Asp Gln Ile Trp Asn Gly 
        515                 520                 525             


Leu Ile Gln Ile Leu Asp Asp Leu Val Leu Val Phe Gly Asp Glu Pro 
    530                 535                 540                 


Met Ser Met Glu Arg Phe Leu Glu Val Phe Asp Ile Gly Leu Glu Gln 
545                 550                 555                 560 


Leu Glu Phe Val Met Ile Pro Gln Thr Leu Asp Gln Val Ser Ile Gly 
                565                 570                 575     


Thr Met Asp Leu Ala Lys Val Asp Asn Lys Gln His Val Tyr Leu Val 
            580                 585                 590         


Gly Met Asn Asp Gly Thr Met Pro Gln Pro Val Thr Ala Ser Ser Leu 
        595                 600                 605             


Ile Thr Asp Glu Glu Lys Lys Tyr Phe Glu Gln Gln Ala Asn Val Glu 
    610                 615                 620                 


Leu Ser Pro Thr Ser Asp Ile Leu Gln Met Asp Glu Ala Phe Val Cys 
625                 630                 635                 640 


Tyr Val Ala Met Thr Arg Ala Lys Gly Asp Val Thr Phe Ser Tyr Ser 
                645                 650                 655     


Leu Met Gly Ser Ser Gly Asp Asp Lys Glu Ile Ser Pro Phe Leu Asn 
            660                 665                 670         


Gln Ile Gln Ser Leu Phe Asn Gln Leu Glu Ile Thr Asn Ile Pro Gln 
        675                 680                 685             


Tyr His Glu Val Asn Pro Leu Ser Leu Met Gln His Ala Lys Gln Thr 
    690                 695                 700                 


Lys Ile Thr Leu Phe Glu Ala Leu Arg Ala Trp Leu Tyr Asp Glu Ile 
705                 710                 715                 720 


Val Ala Asp Ser Trp Leu Asp Ala Tyr Gln Val Ile Arg Asp Ser Asp 
                725                 730                 735     


His Leu Asn Gln Gly Leu Asp Tyr Leu Met Ser Ala Leu Thr Phe Asp 
            740                 745                 750         


Asn Glu Thr Val Lys Leu Gly Glu Thr Leu Ser Lys Asp Leu Tyr Gly 
        755                 760                 765             


Lys Glu Ile Asn Ala Ser Val Ser Arg Phe Glu Gly Tyr Gln Gln Cys 
    770                 775                 780                 


Pro Phe Lys His Tyr Ala Ser His Gly Leu Lys Leu Asn Glu Arg Thr 
785                 790                 795                 800 


Lys Tyr Glu Leu Gln Asn Phe Asp Leu Gly Asp Ile Phe His Ser Val 
                805                 810                 815     


Leu Lys Tyr Ile Ser Glu Arg Ile Asn Gly Asp Phe Lys Gln Leu Asp 
            820                 825                 830         


Leu Lys Lys Ile Arg Gln Leu Thr Asn Glu Ala Leu Glu Glu Ile Leu 
        835                 840                 845             


Pro Lys Val Gln Phe Asn Leu Leu Asn Ser Ser Ala Tyr Tyr Arg Tyr 
    850                 855                 860                 


Leu Ser Arg Arg Ile Gly Ala Ile Val Glu Thr Thr Leu Ser Ala Leu 
865                 870                 875                 880 


Lys Tyr Gln Gly Thr Tyr Ser Lys Phe Met Pro Lys His Phe Glu Thr 
                885                 890                 895     


Ser Phe Arg Arg Lys Pro Arg Thr Asn Asp Glu Leu Ile Ala Gln Thr 
            900                 905                 910         


Leu Thr Thr Thr Gln Gly Ile Pro Ile Asn Ile Arg Gly Gln Ile Asp 
        915                 920                 925             


Arg Ile Asp Thr Tyr Thr Lys Asn Asp Thr Ser Phe Val Asn Ile Ile 
    930                 935                 940                 


Asp Tyr Lys Ser Ser Glu Gly Ser Ala Thr Leu Asp Leu Thr Lys Val 
945                 950                 955                 960 


Tyr Tyr Gly Met Gln Met Gln Met Met Thr Tyr Met Asp Ile Val Leu 
                965                 970                 975     


Gln Asn Lys Gln Arg Leu Gly Leu Thr Asp Ile Val Lys Pro Gly Gly 
            980                 985                 990         


Leu Leu Tyr Phe His Val His Glu  Pro Arg Ile Lys Phe  Lys Ser Trp 
        995                 1000                 1005             


Ser Asp  Ile Asp Glu Asp Lys  Leu Glu Gln Asp Leu  Ile Lys Lys 
    1010                 1015                 1020             


Phe Lys  Leu Ser Gly Leu Val  Asn Ala Asp Gln Thr  Val Ile Asp 
    1025                 1030                 1035             


Ala Leu  Asp Ile Arg Leu Glu  Pro Lys Phe Thr Ser  Asp Ile Val 
    1040                 1045                 1050             


Pro Val  Gly Leu Asn Lys Asp  Gly Ser Leu Ser Lys  Arg Gly Ser 
    1055                 1060                 1065             


Gln Val  Ala Asp Glu Ala Thr  Ile Tyr Lys Phe Ile  Gln His Asn 
    1070                 1075                 1080             


Lys Glu  Asn Phe Ile Glu Thr  Ala Ser Asn Ile Met  Asp Gly His 
    1085                 1090                 1095             


Thr Glu  Val Ala Pro Leu Lys  Tyr Lys Gln Lys Leu  Pro Cys Ala 
    1100                 1105                 1110             


Phe Cys  Ser Tyr Gln Ser Val  Cys His Val Asp Gly  Met Ile Asp 
    1115                 1120                 1125             


Ser Lys  Arg Tyr Arg Thr Val  Asp Glu Thr Ile Asn  Pro Ile Glu 
    1130                 1135                 1140             


Ala Ile  Gln Asn Ile Asn Ile  Asn Asp Glu Phe Gly  Gly Glu Gln 
    1145                 1150                 1155             


<210>  10
<211>  3654
<212>  DNA
<213>  S. aureus

<400>  10
atgacaattc cagagaaacc acaaggcgtg atttggactg acgcgcaatg gcaaagtatt       60

tacgcaactg gacaagatgt acttgttgca gccgcggcag gttcaggtaa aacagctgta      120

ctagttgagc gtattatcca aaagatttta cgtgatggca ttgatgtcga tcgactttta      180

gtcgtaacgt ttacaaactt aagcgcacgt gaaatgaagc atcgtgtaga ccaacgtatt      240

caagaggcat cgattgctga tcctgcaaat gcacacttga aaaaccaacg catcaaaatt      300

catcaagcac aaatatctac actccatagt ttttgcttga aattaattca acagcattat      360

gatgtattaa atattgaccc gaactttaga acaagcagtg aagctgaaaa tattttatta      420

ttagaacaaa cgatagatga ggtcatagaa caacattacg atatccttga tcctgctttt      480

attgaattaa cagagcaatt gtcttcagat agaagtgatg atcagtttcg aatgattatt      540

aaacaattgt atttctttag cgttgcaaat ccaaatccta caaattggtt ggatcaattg      600

gtgacaccat acgaagaaga agcacaacaa gcgcaactta ttcaactact aacagactta      660

tctaaagtat ttatcacagc tgcttatgat gctttaaata aggcgtatga tttgtttagt      720

atgatggata gcgtcgataa acatttagct gttatagaag atgaacgacg tttaatgggg      780

cgtgttttag aaggtggctt tattgatata ccttatttaa ctggtcacga atttggcgcg      840

cgtttgccta atgtaacagc gaaaattaaa gaagcaaatg aaatgatggt cgatgcctta      900

gaagatgcta aacttcagta taaaaaatat aaatcattaa ttgataaagt gaagagtgat      960

tacttttcaa gagaagctga tgatttgaaa gctgatatgc aacaattggc gccacgagta     1020

aagtaccttg cgcgtattgt gaaagatgtt atgtcagaat tcaatcgaaa aaagcgtagc     1080

aaaaatattt tggatttttc tgattatgaa cattttgcat tacaaatttt aactaatgag     1140

gatggttcgc cttcagaaat tgccgaatca taccgtcaac acttccaaga aatattggtc     1200

gatgagtatc aagatacgaa ccgagttcaa gagaaaatac tatcttgcat caaaacgggt     1260

gatgaacata atggtaattt atttatggtt ggagatgtta agcaatccat ttataaattt     1320

agacaagctg atccaagttt atttattgaa aagtatcaac gctttactat agatggagat     1380

ggcactggac gtcgaattga tttgtcgcaa aacttccgtt ctcgaaaaga agtactgtca     1440

acgactaact atatattcaa acatatgatg gatgaacaag tcggtgaagt aaaatatgat     1500

gaagcggcac agttgtatta tggtgcacca tatgatgaat cggaccatcc agtaaactta     1560

aaagtccttg ttgaagcgga tcaagaacat agtgatttaa ctggtagtga acaagaagcg     1620

cattttatag tagaacaagt taaagatatc ttagaacatc aaaaagttta tgatatgaaa     1680

acaggaagct atagaagtgc gacatacaag gatatcgtta ttctagaacg cagctttgga     1740

caagctcgca atttacaaca agcctttaaa aatgaagata ttccattcca tgtgaatagt     1800

cgtgaaggtt actttgaaca aacagaagtc cgcttagtat tatcattttt aagagcgata     1860

gataatccat tacaagatat ttatttagtt gggttaatgc gctccgttat atatcagttc     1920

aaagaagacg aattagctca aattagaata ttgagtccaa atgatgacta cttctatcaa     1980

tcgattgtaa attacattaa tgacgaagca gcagatgcaa ttttagttga taaattaaaa     2040

atgtttttat cagatattca aagttaccaa caatatagta aagatcatcc ggtgtatcag     2100

ttaattgata aattttataa tgatcattat gttattcaat actttagtgg acttattggt     2160

ggacgtggac gacgtgcaaa tctttatggt ttatttaata aagctatcga gtttgagaat     2220

tcaagtttta gaggtttata tcaatttatt cgttttatcg atgaattgat tgaaagaggc     2280

aaagattttg gtgaggaaaa tgtagttggt ccaaacgata atgtcgttag aatgatgaca     2340

attcatagta gtaaaggtct agagtttcca tttgtcattt attctggatt gtcaaaagat     2400

tttaataaac gtgatttgaa acaaccagtt attttaaatc agcaatttgg tctcggaatg     2460

gattattttg atgtggataa agaaatggca tttccatctt tagcttcggt tgcatataga     2520

gctgttgccg aaaaagaact tgtgtcagaa gaaatgcgat tagtctatgt agcattaaca     2580

agagcgaaag aacaacttta tttaattggt agagtgaaaa atgataaatc attactagaa     2640

ctagagcaat tgtctatttc tggtgagcac attgctgtca atgaacgatt aacttcacca     2700

aatccgttcc atcttattta tagtatttta tctaaacatc aatctgcgtc aattccagat     2760

gatttaaaat ttgaaaaaga tatagcacaa attgaagata gtagtcgtcc gaatgtaaat     2820

atttcaattg tgtactttga agatgtgtct acagaaacca ttttagataa tgatgaatat     2880

cgttcggtta atcaattaga aactatgcaa aatggtaatg aagatgttaa agcacaaatt     2940

aaacaccaac ttgattatcg atatccatat gtaaatgata ctaaaaagcc ctcaaaacaa     3000

tctgtttctg aattgaaaag acaatatgaa acagaagaaa gtggcacaag ttacgaacga     3060

gtaaggcaat atcgtatcgg tttttcaacg tatgaacgac ctaaatttct aagtgaacaa     3120

ggtaaacgaa aagcgaatga aattggtacg ttaatgcata cagtgatgca acatttacca     3180

ttcaaaaaag aacgcatatc tgaagttgag ttacatcagt atatcgatgg attaatcgat     3240

aaacatatta tcgaagcaga tgcgaaaaaa gatatccgta tggatgaaat aatgacattt     3300

atcaatagtg agttatattc gattattgct gaagcagagc aagtttatcg tgaattaccg     3360

tttgtagtta accaagcatt agttgaccaa ttgccacaag gagacgaaga cgtctcaatt     3420

attcaaggta tgattgactt aatctttgtt aaagatggtg tgcattattt tgtagactat     3480

aaaaccgatg catttaatcg tcgccgtggg atgacagatg aagaaattgg tacacaatta     3540

aaaaataaat ataagataca gatgaaatat tatcaaaata cgcttcaaac gattcttaat     3600

aaagaagtta aaggttattt atacttcttc aaatttggta cattgcaact atag           3654


<210>  11
<211>  1217
<212>  PRT
<213>  S. aureus

<400>  11

Met Thr Ile Pro Glu Lys Pro Gln Gly Val Ile Trp Thr Asp Ala Gln 
1               5                   10                  15      


Trp Gln Ser Ile Tyr Ala Thr Gly Gln Asp Val Leu Val Ala Ala Ala 
            20                  25                  30          


Ala Gly Ser Gly Lys Thr Ala Val Leu Val Glu Arg Ile Ile Gln Lys 
        35                  40                  45              


Ile Leu Arg Asp Gly Ile Asp Val Asp Arg Leu Leu Val Val Thr Phe 
    50                  55                  60                  


Thr Asn Leu Ser Ala Arg Glu Met Lys His Arg Val Asp Gln Arg Ile 
65                  70                  75                  80  


Gln Glu Ala Ser Ile Ala Asp Pro Ala Asn Ala His Leu Lys Asn Gln 
                85                  90                  95      


Arg Ile Lys Ile His Gln Ala Gln Ile Ser Thr Leu His Ser Phe Cys 
            100                 105                 110         


Leu Lys Leu Ile Gln Gln His Tyr Asp Val Leu Asn Ile Asp Pro Asn 
        115                 120                 125             


Phe Arg Thr Ser Ser Glu Ala Glu Asn Ile Leu Leu Leu Glu Gln Thr 
    130                 135                 140                 


Ile Asp Glu Val Ile Glu Gln His Tyr Asp Ile Leu Asp Pro Ala Phe 
145                 150                 155                 160 


Ile Glu Leu Thr Glu Gln Leu Ser Ser Asp Arg Ser Asp Asp Gln Phe 
                165                 170                 175     


Arg Met Ile Ile Lys Gln Leu Tyr Phe Phe Ser Val Ala Asn Pro Asn 
            180                 185                 190         


Pro Thr Asn Trp Leu Asp Gln Leu Val Thr Pro Tyr Glu Glu Glu Ala 
        195                 200                 205             


Gln Gln Ala Gln Leu Ile Gln Leu Leu Thr Asp Leu Ser Lys Val Phe 
    210                 215                 220                 


Ile Thr Ala Ala Tyr Asp Ala Leu Asn Lys Ala Tyr Asp Leu Phe Ser 
225                 230                 235                 240 


Met Met Asp Ser Val Asp Lys His Leu Ala Val Ile Glu Asp Glu Arg 
                245                 250                 255     


Arg Leu Met Gly Arg Val Leu Glu Gly Gly Phe Ile Asp Ile Pro Tyr 
            260                 265                 270         


Leu Thr Gly His Glu Phe Gly Ala Arg Leu Pro Asn Val Thr Ala Lys 
        275                 280                 285             


Ile Lys Glu Ala Asn Glu Met Met Val Asp Ala Leu Glu Asp Ala Lys 
    290                 295                 300                 


Leu Gln Tyr Lys Lys Tyr Lys Ser Leu Ile Asp Lys Val Lys Ser Asp 
305                 310                 315                 320 


Tyr Phe Ser Arg Glu Ala Asp Asp Leu Lys Ala Asp Met Gln Gln Leu 
                325                 330                 335     


Ala Pro Arg Val Lys Tyr Leu Ala Arg Ile Val Lys Asp Val Met Ser 
            340                 345                 350         


Glu Phe Asn Arg Lys Lys Arg Ser Lys Asn Ile Leu Asp Phe Ser Asp 
        355                 360                 365             


Tyr Glu His Phe Ala Leu Gln Ile Leu Thr Asn Glu Asp Gly Ser Pro 
    370                 375                 380                 


Ser Glu Ile Ala Glu Ser Tyr Arg Gln His Phe Gln Glu Ile Leu Val 
385                 390                 395                 400 


Asp Glu Tyr Gln Asp Thr Asn Arg Val Gln Glu Lys Ile Leu Ser Cys 
                405                 410                 415     


Ile Lys Thr Gly Asp Glu His Asn Gly Asn Leu Phe Met Val Gly Asp 
            420                 425                 430         


Val Lys Gln Ser Ile Tyr Lys Phe Arg Gln Ala Asp Pro Ser Leu Phe 
        435                 440                 445             


Ile Glu Lys Tyr Gln Arg Phe Thr Ile Asp Gly Asp Gly Thr Gly Arg 
    450                 455                 460                 


Arg Ile Asp Leu Ser Gln Asn Phe Arg Ser Arg Lys Glu Val Leu Ser 
465                 470                 475                 480 


Thr Thr Asn Tyr Ile Phe Lys His Met Met Asp Glu Gln Val Gly Glu 
                485                 490                 495     


Val Lys Tyr Asp Glu Ala Ala Gln Leu Tyr Tyr Gly Ala Pro Tyr Asp 
            500                 505                 510         


Glu Ser Asp His Pro Val Asn Leu Lys Val Leu Val Glu Ala Asp Gln 
        515                 520                 525             


Glu His Ser Asp Leu Thr Gly Ser Glu Gln Glu Ala His Phe Ile Val 
    530                 535                 540                 


Glu Gln Val Lys Asp Ile Leu Glu His Gln Lys Val Tyr Asp Met Lys 
545                 550                 555                 560 


Thr Gly Ser Tyr Arg Ser Ala Thr Tyr Lys Asp Ile Val Ile Leu Glu 
                565                 570                 575     


Arg Ser Phe Gly Gln Ala Arg Asn Leu Gln Gln Ala Phe Lys Asn Glu 
            580                 585                 590         


Asp Ile Pro Phe His Val Asn Ser Arg Glu Gly Tyr Phe Glu Gln Thr 
        595                 600                 605             


Glu Val Arg Leu Val Leu Ser Phe Leu Arg Ala Ile Asp Asn Pro Leu 
    610                 615                 620                 


Gln Asp Ile Tyr Leu Val Gly Leu Met Arg Ser Val Ile Tyr Gln Phe 
625                 630                 635                 640 


Lys Glu Asp Glu Leu Ala Gln Ile Arg Ile Leu Ser Pro Asn Asp Asp 
                645                 650                 655     


Tyr Phe Tyr Gln Ser Ile Val Asn Tyr Ile Asn Asp Glu Ala Ala Asp 
            660                 665                 670         


Ala Ile Leu Val Asp Lys Leu Lys Met Phe Leu Ser Asp Ile Gln Ser 
        675                 680                 685             


Tyr Gln Gln Tyr Ser Lys Asp His Pro Val Tyr Gln Leu Ile Asp Lys 
    690                 695                 700                 


Phe Tyr Asn Asp His Tyr Val Ile Gln Tyr Phe Ser Gly Leu Ile Gly 
705                 710                 715                 720 


Gly Arg Gly Arg Arg Ala Asn Leu Tyr Gly Leu Phe Asn Lys Ala Ile 
                725                 730                 735     


Glu Phe Glu Asn Ser Ser Phe Arg Gly Leu Tyr Gln Phe Ile Arg Phe 
            740                 745                 750         


Ile Asp Glu Leu Ile Glu Arg Gly Lys Asp Phe Gly Glu Glu Asn Val 
        755                 760                 765             


Val Gly Pro Asn Asp Asn Val Val Arg Met Met Thr Ile His Ser Ser 
    770                 775                 780                 


Lys Gly Leu Glu Phe Pro Phe Val Ile Tyr Ser Gly Leu Ser Lys Asp 
785                 790                 795                 800 


Phe Asn Lys Arg Asp Leu Lys Gln Pro Val Ile Leu Asn Gln Gln Phe 
                805                 810                 815     


Gly Leu Gly Met Asp Tyr Phe Asp Val Asp Lys Glu Met Ala Phe Pro 
            820                 825                 830         


Ser Leu Ala Ser Val Ala Tyr Arg Ala Val Ala Glu Lys Glu Leu Val 
        835                 840                 845             


Ser Glu Glu Met Arg Leu Val Tyr Val Ala Leu Thr Arg Ala Lys Glu 
    850                 855                 860                 


Gln Leu Tyr Leu Ile Gly Arg Val Lys Asn Asp Lys Ser Leu Leu Glu 
865                 870                 875                 880 


Leu Glu Gln Leu Ser Ile Ser Gly Glu His Ile Ala Val Asn Glu Arg 
                885                 890                 895     


Leu Thr Ser Pro Asn Pro Phe His Leu Ile Tyr Ser Ile Leu Ser Lys 
            900                 905                 910         


His Gln Ser Ala Ser Ile Pro Asp Asp Leu Lys Phe Glu Lys Asp Ile 
        915                 920                 925             


Ala Gln Ile Glu Asp Ser Ser Arg Pro Asn Val Asn Ile Ser Ile Val 
    930                 935                 940                 


Tyr Phe Glu Asp Val Ser Thr Glu Thr Ile Leu Asp Asn Asp Glu Tyr 
945                 950                 955                 960 


Arg Ser Val Asn Gln Leu Glu Thr Met Gln Asn Gly Asn Glu Asp Val 
                965                 970                 975     


Lys Ala Gln Ile Lys His Gln Leu Asp Tyr Arg Tyr Pro Tyr Val Asn 
            980                 985                 990         


Asp Thr Lys Lys Pro Ser Lys Gln  Ser Val Ser Glu Leu  Lys Arg Gln 
        995                 1000                 1005             


Tyr Glu  Thr Glu Glu Ser Gly  Thr Ser Tyr Glu Arg  Val Arg Gln 
    1010                 1015                 1020             


Tyr Arg  Ile Gly Phe Ser Thr  Tyr Glu Arg Pro Lys  Phe Leu Ser 
    1025                 1030                 1035             


Glu Gln  Gly Lys Arg Lys Ala  Asn Glu Ile Gly Thr  Leu Met His 
    1040                 1045                 1050             


Thr Val  Met Gln His Leu Pro  Phe Lys Lys Glu Arg  Ile Ser Glu 
    1055                 1060                 1065             


Val Glu  Leu His Gln Tyr Ile  Asp Gly Leu Ile Asp  Lys His Ile 
    1070                 1075                 1080             


Ile Glu  Ala Asp Ala Lys Lys  Asp Ile Arg Met Asp  Glu Ile Met 
    1085                 1090                 1095             


Thr Phe  Ile Asn Ser Glu Leu  Tyr Ser Ile Ile Ala  Glu Ala Glu 
    1100                 1105                 1110             


Gln Val  Tyr Arg Glu Leu Pro  Phe Val Val Asn Gln  Ala Leu Val 
    1115                 1120                 1125             


Asp Gln  Leu Pro Gln Gly Asp  Glu Asp Val Ser Ile  Ile Gln Gly 
    1130                 1135                 1140             


Met Ile  Asp Leu Ile Phe Val  Lys Asp Gly Val His  Tyr Phe Val 
    1145                 1150                 1155             


Asp Tyr  Lys Thr Asp Ala Phe  Asn Arg Arg Arg Gly  Met Thr Asp 
    1160                 1165                 1170             


Glu Glu  Ile Gly Thr Gln Leu  Lys Asn Lys Tyr Lys  Ile Gln Met 
    1175                 1180                 1185             


Lys Tyr  Tyr Gln Asn Thr Leu  Gln Thr Ile Leu Asn  Lys Glu Val 
    1190                 1195                 1200             


Lys Gly  Tyr Leu Tyr Phe Phe  Lys Phe Gly Thr Leu  Gln Leu 
    1205                 1210                 1215         


