                         SEQUENCE LISTING

<110>  STCUBE PHARMACEUTICALS, INC.
 
<120>  METHODS OF TREATING CANCER USING ANTIBODIES AND MOLECULES THAT 
       BIND TO  BTN1A1 OR BTN1A1-LIGANDS

<130>  13532-020-228

<140>  TBA
<141>  

<150>  62/516,071
<151>  2017-06-06

<160>  14    

<170>  PatentIn version 3.5

<210>  1
<211>  526
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Ala Val Phe Pro Ser Ser Gly Leu Pro Arg Cys Leu Leu Thr Leu 
1               5                   10                  15      


Ile Leu Leu Gln Leu Pro Lys Leu Asp Ser Ala Pro Phe Asp Val Ile 
            20                  25                  30          


Gly Pro Pro Glu Pro Ile Leu Ala Val Val Gly Glu Asp Ala Lys Leu 
        35                  40                  45              


Pro Cys Arg Leu Ser Pro Asn Ala Ser Ala Glu His Leu Glu Leu Arg 
    50                  55                  60                  


Trp Phe Arg Lys Lys Val Ser Pro Ala Val Leu Val His Arg Asp Gly 
65                  70                  75                  80  


Arg Glu Gln Glu Ala Glu Gln Met Pro Glu Tyr Arg Gly Arg Ala Thr 
                85                  90                  95      


Leu Val Gln Asp Gly Ile Ala Lys Gly Arg Val Ala Leu Arg Ile Arg 
            100                 105                 110         


Gly Val Arg Val Ser Asp Asp Gly Glu Tyr Thr Cys Phe Phe Arg Glu 
        115                 120                 125             


Asp Gly Ser Tyr Glu Glu Ala Leu Val His Leu Lys Val Ala Ala Leu 
    130                 135                 140                 


Gly Ser Asp Pro His Ile Ser Met Gln Val Gln Glu Asn Gly Glu Ile 
145                 150                 155                 160 


Cys Leu Glu Cys Thr Ser Val Gly Trp Tyr Pro Glu Pro Gln Val Gln 
                165                 170                 175     


Trp Arg Thr Ser Lys Gly Glu Lys Phe Pro Ser Thr Ser Glu Ser Arg 
            180                 185                 190         


Asn Pro Asp Glu Glu Gly Leu Phe Thr Val Ala Ala Ser Val Ile Ile 
        195                 200                 205             


Arg Asp Thr Ser Ala Lys Asn Val Ser Cys Tyr Ile Gln Asn Leu Leu 
    210                 215                 220                 


Leu Gly Gln Glu Lys Lys Val Glu Ile Ser Ile Pro Ala Ser Ser Leu 
225                 230                 235                 240 


Pro Arg Leu Thr Pro Trp Ile Val Ala Val Ala Val Ile Leu Met Val 
                245                 250                 255     


Leu Gly Leu Leu Thr Ile Gly Ser Ile Phe Phe Thr Trp Arg Leu Tyr 
            260                 265                 270         


Asn Glu Arg Pro Arg Glu Arg Arg Asn Glu Phe Ser Ser Lys Glu Arg 
        275                 280                 285             


Leu Leu Glu Glu Leu Lys Trp Lys Lys Ala Thr Leu His Ala Val Asp 
    290                 295                 300                 


Val Thr Leu Asp Pro Asp Thr Ala His Pro His Leu Phe Leu Tyr Glu 
305                 310                 315                 320 


Asp Ser Lys Ser Val Arg Leu Glu Asp Ser Arg Gln Lys Leu Pro Glu 
                325                 330                 335     


Lys Thr Glu Arg Phe Asp Ser Trp Pro Cys Val Leu Gly Arg Glu Thr 
            340                 345                 350         


Phe Thr Ser Gly Arg His Tyr Trp Glu Val Glu Val Gly Asp Arg Thr 
        355                 360                 365             


Asp Trp Ala Ile Gly Val Cys Arg Glu Asn Val Met Lys Lys Gly Phe 
    370                 375                 380                 


Asp Pro Met Thr Pro Glu Asn Gly Phe Trp Ala Val Glu Leu Tyr Gly 
385                 390                 395                 400 


Asn Gly Tyr Trp Ala Leu Thr Pro Leu Arg Thr Pro Leu Pro Leu Ala 
                405                 410                 415     


Gly Pro Pro Arg Arg Val Gly Ile Phe Leu Asp Tyr Glu Ser Gly Asp 
            420                 425                 430         


Ile Ser Phe Tyr Asn Met Asn Asp Gly Ser Asp Ile Tyr Thr Phe Ser 
        435                 440                 445             


Asn Val Thr Phe Ser Gly Pro Leu Arg Pro Phe Phe Cys Leu Trp Ser 
    450                 455                 460                 


Ser Gly Lys Lys Pro Leu Thr Ile Cys Pro Ile Ala Asp Gly Pro Glu 
465                 470                 475                 480 


Arg Val Thr Val Ile Ala Asn Ala Gln Asp Leu Ser Lys Glu Ile Pro 
                485                 490                 495     


Leu Ser Pro Met Gly Glu Asp Ser Ala Pro Arg Asp Ala Asp Thr Leu 
            500                 505                 510         


His Ser Lys Leu Ile Pro Thr Gln Pro Ser Gln Gly Ala Pro 
        515                 520                 525     


<210>  2
<211>  1581
<212>  DNA
<213>  Homo sapiens

<400>  2
atggcagttt tcccaagctc cggtctcccc agatgtctgc tcaccctcat tctcctccag       60

ctgcccaaac tggattcagc tccctttgac gtgattggac ccccggagcc catcctggcc      120

gttgtgggtg aggacgccaa gctgccctgt cgcctgtctc cgaacgcgag cgccgagcac      180

ttggagctac gctggttccg aaagaaggtt tcgccggccg tgctggtgca tagggacggg      240

cgcgagcagg aagccgagca gatgcccgag taccgcgggc gggcgacgct ggtccaggac      300

ggcatcgcca aggggcgcgt ggccttgagg atccgtggcg tcagagtctc tgacgacggg      360

gagtacacgt gctttttcag ggaggatgga agctacgaag aagccctggt gcatctgaag      420

gtggctgctc tgggctctga ccctcacatc agtatgcaag ttcaagagaa tggagaaatc      480

tgtctggagt gcacctcagt gggatggtac ccagagcccc aggtgcagtg gagaacttcc      540

aagggagaga agtttccatc tacatcagag tccaggaatc ctgatgaaga aggtttgttc      600

actgtggctg cttcagtgat catcagagac acttctgcga aaaatgtgtc ctgctacatc      660

cagaatctcc ttcttggcca ggagaagaaa gtagaaatat ccataccagc ttcctccctc      720

ccaaggctga ctccctggat agtggctgtg gctgtcatcc tgatggttct aggacttctc      780

accattgggt ccatattttt cacttggaga ctatacaacg aaagacccag agagaggagg      840

aatgaattca gctctaaaga gagactcctg gaagaactca aatggaaaaa ggctaccttg      900

catgcagttg atgtgactct ggacccagac acagctcatc cccacctctt tctttatgag      960

gattcaaaat ctgttcgact ggaagattca cgtcagaaac tgcctgagaa aacagagaga     1020

tttgactcct ggccctgtgt gttgggccgt gagaccttca cctcaggaag gcattactgg     1080

gaggtggagg tgggagacag gactgactgg gcaatcggcg tgtgtaggga gaatgtgatg     1140

aagaaaggat ttgaccccat gactcctgag aatgggttct gggctgtaga gttgtatgga     1200

aatgggtact gggccctcac tcctctccgg acccctctcc cattggcagg gcccccacgc     1260

cgggttggga ttttcctaga ctatgaatca ggagacatct ccttctacaa catgaatgat     1320

ggatctgata tctatacttt ctccaatgtc actttctctg gccccctccg gcccttcttt     1380

tgcctatggt ctagcggtaa aaagcccctg accatctgcc caattgctga tgggcctgag     1440

agggtcacag tcattgctaa tgcccaggac ctttctaagg agatcccatt gtcccccatg     1500

ggggaggact ctgcccctag ggatgcagac actctccatt ctaagctaat ccctacccaa     1560

cccagccaag gggcacctta a                                               1581


<210>  3
<211>  443
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  3

Ala Pro Phe Asp Val Ile Gly Pro Pro Glu Pro Ile Leu Ala Val Val 
1               5                   10                  15      


Gly Glu Asp Ala Glu Leu Pro Cys Arg Leu Ser Pro Asn Ala Ser Ala 
            20                  25                  30          


Glu His Leu Glu Leu Arg Trp Phe Arg Lys Lys Val Ser Pro Ala Val 
        35                  40                  45              


Leu Val His Arg Asp Gly Arg Glu Gln Glu Ala Glu Gln Met Pro Glu 
    50                  55                  60                  


Tyr Arg Gly Arg Ala Thr Leu Val Gln Asp Gly Ile Ala Lys Gly Arg 
65                  70                  75                  80  


Val Ala Leu Arg Ile Arg Gly Val Arg Val Ser Asp Asp Gly Glu Tyr 
                85                  90                  95      


Thr Cys Phe Phe Arg Glu Asp Gly Ser Tyr Glu Glu Ala Leu Val His 
            100                 105                 110         


Leu Lys Val Ala Ala Leu Gly Ser Asp Pro His Ile Ser Met Gln Val 
        115                 120                 125             


Gln Glu Asn Gly Glu Ile Cys Leu Glu Cys Thr Ser Val Gly Trp Tyr 
    130                 135                 140                 


Pro Glu Pro Gln Val Gln Trp Arg Thr Ser Lys Gly Glu Lys Phe Pro 
145                 150                 155                 160 


Ser Thr Ser Glu Ser Arg Asn Pro Asp Glu Glu Gly Leu Phe Thr Val 
                165                 170                 175     


Ala Ala Ser Val Ile Ile Arg Asp Thr Ser Ala Lys Asn Val Ser Cys 
            180                 185                 190         


Tyr Ile Gln Asn Leu Leu Leu Gly Gln Glu Lys Lys Val Glu Ile Ser 
        195                 200                 205             


Ile Pro Ala Ser Ser Leu Pro Arg Asp Lys Thr His Thr Cys Pro Pro 
    210                 215                 220                 


Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro 
225                 230                 235                 240 


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
                245                 250                 255     


Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
            260                 265                 270         


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
        275                 280                 285             


Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
    290                 295                 300                 


Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
305                 310                 315                 320 


Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
                325                 330                 335     


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu 
            340                 345                 350         


Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
        355                 360                 365             


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
    370                 375                 380                 


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
385                 390                 395                 400 


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
                405                 410                 415     


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
            420                 425                 430         


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440             


<210>  4
<211>  222
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  4

Ala Pro Phe Asp Val Ile Gly Pro Pro Glu Pro Ile Leu Ala Val Val 
1               5                   10                  15      


Gly Glu Asp Ala Glu Leu Pro Cys Arg Leu Ser Pro Asn Ala Ser Ala 
            20                  25                  30          


Glu His Leu Glu Leu Arg Trp Phe Arg Lys Lys Val Ser Pro Ala Val 
        35                  40                  45              


Leu Val His Arg Asp Gly Arg Glu Gln Glu Ala Glu Gln Met Pro Glu 
    50                  55                  60                  


Tyr Arg Gly Arg Ala Thr Leu Val Gln Asp Gly Ile Ala Lys Gly Arg 
65                  70                  75                  80  


Val Ala Leu Arg Ile Arg Gly Val Arg Val Ser Asp Asp Gly Glu Tyr 
                85                  90                  95      


Thr Cys Phe Phe Arg Glu Asp Gly Ser Tyr Glu Glu Ala Leu Val His 
            100                 105                 110         


Leu Lys Val Ala Ala Leu Gly Ser Asp Pro His Ile Ser Met Gln Val 
        115                 120                 125             


Gln Glu Asn Gly Glu Ile Cys Leu Glu Cys Thr Ser Val Gly Trp Tyr 
    130                 135                 140                 


Pro Glu Pro Gln Val Gln Trp Arg Thr Ser Lys Gly Glu Lys Phe Pro 
145                 150                 155                 160 


Ser Thr Ser Glu Ser Arg Asn Pro Asp Glu Glu Gly Leu Phe Thr Val 
                165                 170                 175     


Ala Ala Ser Val Ile Ile Arg Asp Thr Ser Ala Lys Asn Val Ser Cys 
            180                 185                 190         


Tyr Ile Gln Asn Leu Leu Leu Gly Gln Glu Lys Lys Val Glu Ile Ser 
        195                 200                 205             


Ile Pro Ala Ser Ser Leu Pro Arg His His His His His His 
    210                 215                 220         


<210>  5
<211>  524
<212>  PRT
<213>  Mouse

<400>  5

Met Ala Val Pro Thr Asn Ser Cys Leu Leu Val Cys Leu Leu Thr Leu 
1               5                   10                  15      


Thr Val Leu Gln Leu Pro Thr Leu Asp Ser Ala Ala Pro Phe Asp Val 
            20                  25                  30          


Thr Ala Pro Gln Glu Pro Val Leu Ala Leu Val Gly Ser Asp Ala Glu 
        35                  40                  45              


Leu Thr Cys Gly Phe Ser Pro Asn Ala Ser Ser Glu Tyr Met Glu Leu 
    50                  55                  60                  


Leu Trp Phe Arg Gln Thr Arg Ser Lys Ala Val Leu Leu Tyr Arg Asp 
65                  70                  75                  80  


Gly Gln Glu Gln Glu Gly Gln Gln Met Thr Glu Tyr Arg Gly Arg Ala 
                85                  90                  95      


Thr Leu Ala Thr Ala Gly Leu Leu Asp Gly Arg Ala Thr Leu Leu Ile 
            100                 105                 110         


Arg Asp Val Arg Val Ser Asp Gln Gly Glu Tyr Arg Cys Leu Phe Lys 
        115                 120                 125             


Asp Asn Asp Asp Phe Glu Glu Ala Ala Val Tyr Leu Lys Val Ala Ala 
    130                 135                 140                 


Val Gly Ser Asp Pro Gln Ile Ser Met Thr Val Gln Glu Asn Gly Glu 
145                 150                 155                 160 


Met Glu Leu Glu Cys Thr Ser Ser Gly Trp Tyr Pro Glu Pro Gln Val 
                165                 170                 175     


Gln Trp Arg Thr Gly Asn Arg Glu Met Leu Pro Ser Thr Ser Glu Ser 
            180                 185                 190         


Lys Lys His Asn Glu Glu Gly Leu Phe Thr Val Ala Val Ser Met Met 
        195                 200                 205             


Ile Arg Asp Ser Ser Ile Lys Asn Met Ser Cys Cys Ile Gln Asn Ile 
    210                 215                 220                 


Leu Leu Gly Gln Gly Lys Glu Val Glu Ile Ser Leu Pro Ala Pro Phe 
225                 230                 235                 240 


Val Pro Arg Leu Thr Pro Trp Ile Val Ala Val Ala Ile Ile Leu Leu 
                245                 250                 255     


Ala Leu Gly Phe Leu Thr Ile Gly Ser Ile Phe Phe Thr Trp Lys Leu 
            260                 265                 270         


Tyr Lys Glu Arg Ser Ser Leu Arg Lys Lys Glu Phe Gly Ser Lys Glu 
        275                 280                 285             


Arg Leu Leu Glu Glu Leu Arg Cys Lys Lys Thr Val Leu His Glu Val 
    290                 295                 300                 


Asp Val Thr Leu Asp Pro Asp Thr Ala His Pro His Leu Phe Leu Tyr 
305                 310                 315                 320 


Glu Asp Ser Lys Ser Val Arg Leu Glu Asp Ser Arg Gln Ile Leu Pro 
                325                 330                 335     


Asp Arg Pro Glu Arg Phe Asp Ser Trp Pro Cys Val Leu Gly Arg Glu 
            340                 345                 350         


Thr Phe Thr Ser Gly Arg His Tyr Trp Glu Val Glu Val Gly Asp Arg 
        355                 360                 365             


Thr Asp Trp Ala Ile Gly Val Cys Arg Glu Asn Val Val Lys Lys Gly 
    370                 375                 380                 


Phe Asp Pro Met Thr Pro Asp Asn Gly Phe Trp Ala Val Glu Leu Tyr 
385                 390                 395                 400 


Gly Asn Gly Tyr Trp Ala Leu Thr Pro Leu Arg Thr Ser Leu Arg Leu 
                405                 410                 415     


Ala Gly Pro Pro Arg Arg Val Gly Val Phe Leu Asp Tyr Asp Ala Gly 
            420                 425                 430         


Asp Ile Ser Phe Tyr Asn Met Ser Asn Gly Ser Leu Ile Tyr Thr Phe 
        435                 440                 445             


Pro Ser Ile Ser Phe Ser Gly Pro Leu Arg Pro Phe Phe Cys Leu Trp 
    450                 455                 460                 


Ser Cys Gly Lys Lys Pro Leu Thr Ile Cys Ser Thr Ala Asn Gly Pro 
465                 470                 475                 480 


Glu Lys Val Thr Val Ile Ala Asn Val Gln Asp Asp Ile Pro Leu Ser 
                485                 490                 495     


Pro Leu Gly Glu Gly Cys Thr Ser Gly Asp Lys Asp Thr Leu His Ser 
            500                 505                 510         


Lys Leu Ile Pro Phe Ser Pro Ser Gln Ala Ala Pro 
        515                 520                 


<210>  6
<211>  1575
<212>  DNA
<213>  Mouse

<400>  6
atggcagttc ccaccaactc ctgcctcctg gtctgtctgc tcaccctcac tgtcctacag       60

ctgcccacgc tggattcggc agctcccttc gatgtgaccg cacctcagga gccagtgttg      120

gccctagtgg gctcagatgc cgagctgacc tgtggctttt ccccaaacgc gagctcagaa      180

tacatggagc tgctgtggtt tcgacagacg aggtcgaaag cggtacttct ataccgggat      240

ggccaggagc aggagggcca gcagatgacg gagtaccgcg ggagggcgac gctggcgaca      300

gccgggcttc tagacggccg cgctactctg ctgatccgag atgtcagggt ctcagaccag      360

ggggagtacc ggtgcctttt caaagacaac gacgacttcg aggaggccgc cgtatacctc      420

aaagtggctg ctgtgggttc agatcctcaa atcagtatga cggttcaaga gaatggagaa      480

atggagctgg agtgcacctc ctctggatgg tacccagagc ctcaggtgca gtggagaaca      540

ggcaacagag agatgctacc atccacgtca gagtccaaga agcataatga ggaaggcctg      600

ttcactgtgg cagtttcaat gatgatcaga gacagctcca taaagaacat gtcctgctgc      660

atccagaata tcctccttgg ccaggggaag gaagtagaga tctccttacc agctcccttc      720

gtgccaaggc tgactccctg gatagtagct gtggctatca tcttactggc cttaggattt      780

ctcaccattg ggtccatatt tttcacttgg aaactataca aggaaagatc cagtctgcgg      840

aagaaggaat ttggctctaa agagagactt ctggaagaac tcagatgcaa aaagactgta      900

ctgcatgaag ttgacgtgac tctggatcca gacacagccc acccccacct cttcctgtat      960

gaagattcaa agtcagttcg attggaagat tcacgtcaga tcctgcctga tagaccagag     1020

agatttgact cctggccctg tgtgttgggc cgtgagacct ttacttcagg gagacattac     1080

tgggaggtgg aggtgggaga tagaactgac tgggccattg gtgtgtgtag ggagaatgtg     1140

gtgaagaaag ggtttgaccc catgactcct gataatgggt tctgggctgt ggagttgtat     1200

ggaaatgggt actgggccct caccccactc aggacctctc tccgattagc agggccccct     1260

cgcagagttg gggtttttct ggactatgac gcaggagaca tttccttcta caacatgagt     1320

aacggatctc ttatctatac tttccctagc atctctttct ctggccccct ccgtcccttc     1380

ttttgtctgt ggtcctgtgg taaaaagccc ctgaccatct gttcaactgc caatgggcct     1440

gagaaagtca cagtcattgc taatgtccag gacgacattc ccttgtcccc gctgggggaa     1500

ggctgtactt ctggagacaa agacactctc cattctaaac tgatcccgtt ctcacctagc     1560

caagcggcac cataa                                                      1575


<210>  7
<211>  135
<212>  PRT
<213>  Homo sapiens

<400>  7

Met Ala Cys Gly Leu Val Ala Ser Asn Leu Asn Leu Lys Pro Gly Glu 
1               5                   10                  15      


Cys Leu Arg Val Arg Gly Glu Val Ala Pro Asp Ala Lys Ser Phe Val 
            20                  25                  30          


Leu Asn Leu Gly Lys Asp Ser Asn Asn Leu Cys Leu His Phe Asn Pro 
        35                  40                  45              


Arg Phe Asn Ala His Gly Asp Ala Asn Thr Ile Val Cys Asn Ser Lys 
    50                  55                  60                  


Asp Gly Gly Ala Trp Gly Thr Glu Gln Arg Glu Ala Val Phe Pro Phe 
65                  70                  75                  80  


Gln Pro Gly Ser Val Ala Glu Val Cys Ile Thr Phe Asp Gln Ala Asn 
                85                  90                  95      


Leu Thr Val Lys Leu Pro Asp Gly Tyr Glu Phe Lys Phe Pro Asn Arg 
            100                 105                 110         


Leu Asn Leu Glu Ala Ile Asn Tyr Met Ala Ala Asp Gly Asp Phe Lys 
        115                 120                 125             


Ile Lys Cys Val Ala Phe Asp 
    130                 135 


<210>  8
<211>  408
<212>  DNA
<213>  Homo sapiens

<400>  8
atggcttgtg gtctggtcgc cagcaacctg aatctcaaac ctggagagtg ccttcgagtg       60

cgaggcgagg tggctcctga cgctaagagc ttcgtgctga acctgggcaa agacagcaac      120

aacctgtgcc tgcacttcaa ccctcgcttc aacgcccacg gcgacgccaa caccatcgtg      180

tgcaacagca aggacggcgg ggcctggggg accgagcagc gggaggctgt ctttcccttc      240

cagcctggaa gtgttgcaga ggtgtgcatc accttcgacc aggccaacct gaccgtcaag      300

ctgccagatg gatacgaatt caagttcccc aaccgcctca acctggaggc catcaactac      360

atggcagctg acggtgactt caagatcaaa tgtgtggcct ttgactga                   408


<210>  9
<211>  246
<212>  PRT
<213>  Homo sapiens

<400>  9

Met Ala Phe Ser Gly Ser Gln Ala Pro Tyr Leu Ser Pro Ala Val Pro 
1               5                   10                  15      


Phe Ser Gly Thr Ile Gln Gly Gly Leu Gln Asp Gly Leu Gln Ile Thr 
            20                  25                  30          


Val Asn Gly Thr Val Leu Ser Ser Ser Gly Thr Arg Phe Ala Val Asn 
        35                  40                  45              


Phe Gln Thr Gly Phe Ser Gly Asn Asp Ile Ala Phe His Phe Asn Pro 
    50                  55                  60                  


Arg Phe Glu Asp Gly Gly Tyr Val Val Cys Asn Thr Arg Gln Asn Gly 
65                  70                  75                  80  


Ser Trp Gly Pro Glu Glu Arg Lys Thr His Met Pro Phe Gln Lys Gly 
                85                  90                  95      


Met Pro Phe Asp Leu Cys Phe Leu Val Gln Ser Ser Asp Phe Lys Val 
            100                 105                 110         


Met Val Asn Gly Ile Leu Phe Val Gln Tyr Phe His Arg Val Pro Phe 
        115                 120                 125             


His Arg Val Asp Thr Ile Ser Val Asn Gly Ser Val Gln Leu Ser Tyr 
    130                 135                 140                 


Ile Ser Phe Gln Pro Pro Gly Val Trp Pro Ala Asn Pro Ala Pro Ile 
145                 150                 155                 160 


Thr Gln Thr Val Ile His Thr Val Gln Ser Ala Pro Gly Gln Met Phe 
                165                 170                 175     


Ser Thr Pro Ala Ile Pro Pro Met Met Tyr Pro His Pro Ala Tyr Pro 
            180                 185                 190         


Met Pro Phe Ile Thr Thr Ile Leu Gly Gly Leu Tyr Pro Ser Lys Ser 
        195                 200                 205             


Ile Leu Leu Ser Gly Thr Val Leu Pro Ser Ala Gln Arg Cys Gly Ser 
    210                 215                 220                 


Cys Val Lys Leu Thr Ala Ser Arg Trp Pro Trp Met Val Ser Thr Cys 
225                 230                 235                 240 


Leu Asn Thr Thr Ile Ala 
                245     


<210>  10
<211>  971
<212>  DNA
<213>  Homo sapiens

<400>  10
atggccttca gcggttccca ggctccctac ctgagtccag ctgtcccctt ttctgggact       60

attcaaggag gtctccagga cggacttcag atcactgtca atgggaccgt tctcagctcc      120

agtggaacca ggtttgctgt gaactttcag actggcttca gtggaaatga cattgccttc      180

cacttcaacc ctcggtttga agatggaggg tacgtggtgt gcaacacgag gcagaacgga      240

agctgggggc ccgaggagag gaagacacac atgcctttcc agaaggggat gccctttgac      300

ctctgcttcc tggtgcagag ctcagatttc aaggtgatgg tgaacgggat cctcttcgtg      360

cagtacttcc accgcgtgcc cttccaccgt gtggacacca tctccgtcaa tggctctgtg      420

cagctgtcct acatcagctt ccagcctccc ggcgtgtggc ctgccaaccc ggctcccatt      480

acccagacag tcatccacac agtgcagagc gcccctggac agatgttctc tactcccgcc      540

atcccactat gatgtacccc caccccgcct atccgatgcc tttcatcacc accattctgg      600

gagggctgta cccatccaag tccatcctcc tgtcaggcac tgtcctgccc agtgctcaga      660

ggttccacat caacctgtgc tctgggaacc acatcgcctt ccacctgaac ccccgttttg      720

atgagaatgc tgtggtccgc aacacccaga tcgacaactc ctgggggtct gaggagcgaa      780

gtctgccccg aaaaatgccc ttcgtccgtg gccagagctt ctcagtgtgg atcttgtgtg      840

aagctcactg cctcaaggtg gccgtggatg gtcagcacct gtttgaatac taccatcgcc      900

tgaggaacct gcccaccatc aacagactgg aagtgggggg cgacatccag ctgacccatg      960

tgcagacata g                                                           971


<210>  11
<211>  926
<212>  PRT
<213>  Homo sapiens

<400>  11

Met Asp Met Phe Pro Leu Thr Trp Val Phe Leu Ala Leu Tyr Phe Ser 
1               5                   10                  15      


Arg His Gln Val Arg Gly Gln Pro Asp Pro Pro Cys Gly Gly Arg Leu 
            20                  25                  30          


Asn Ser Lys Asp Ala Gly Tyr Ile Thr Ser Pro Gly Tyr Pro Gln Asp 
        35                  40                  45              


Tyr Pro Ser His Gln Asn Cys Glu Trp Ile Val Tyr Ala Pro Glu Pro 
    50                  55                  60                  


Asn Gln Lys Ile Val Leu Asn Phe Asn Pro His Phe Glu Ile Glu Lys 
65                  70                  75                  80  


His Asp Cys Lys Tyr Asp Phe Ile Glu Ile Arg Asp Gly Asp Ser Glu 
                85                  90                  95      


Ser Ala Asp Leu Leu Gly Lys His Cys Gly Asn Ile Ala Pro Pro Thr 
            100                 105                 110         


Ile Ile Ser Ser Gly Ser Met Leu Tyr Ile Lys Phe Thr Ser Asp Tyr 
        115                 120                 125             


Ala Arg Gln Gly Ala Gly Phe Ser Leu Arg Tyr Glu Ile Phe Lys Thr 
    130                 135                 140                 


Gly Ser Glu Asp Cys Ser Lys Asn Phe Thr Ser Pro Asn Gly Thr Ile 
145                 150                 155                 160 


Glu Ser Pro Gly Phe Pro Glu Lys Tyr Pro His Asn Leu Asp Cys Thr 
                165                 170                 175     


Phe Thr Ile Leu Ala Lys Pro Lys Met Glu Ile Ile Leu Gln Phe Leu 
            180                 185                 190         


Ile Phe Asp Leu Glu His Asp Pro Leu Gln Val Gly Glu Gly Asp Cys 
        195                 200                 205             


Lys Tyr Asp Trp Leu Asp Ile Trp Asp Gly Ile Pro His Val Gly Pro 
    210                 215                 220                 


Leu Ile Gly Lys Tyr Cys Gly Thr Lys Thr Pro Ser Glu Leu Arg Ser 
225                 230                 235                 240 


Ser Thr Gly Ile Leu Ser Leu Thr Phe His Thr Asp Met Ala Val Ala 
                245                 250                 255     


Lys Asp Gly Phe Ser Ala Arg Tyr Tyr Leu Val His Gln Glu Pro Leu 
            260                 265                 270         


Glu Asn Phe Gln Cys Asn Val Pro Leu Gly Met Glu Ser Gly Arg Ile 
        275                 280                 285             


Ala Asn Glu Gln Ile Ser Ala Ser Ser Thr Tyr Ser Asp Gly Arg Trp 
    290                 295                 300                 


Thr Pro Gln Gln Ser Arg Leu His Gly Asp Asp Asn Gly Trp Thr Pro 
305                 310                 315                 320 


Asn Leu Asp Ser Asn Lys Glu Tyr Leu Gln Val Asp Leu Arg Phe Leu 
                325                 330                 335     


Thr Met Leu Thr Ala Ile Ala Thr Gln Gly Ala Ile Ser Arg Glu Thr 
            340                 345                 350         


Gln Asn Gly Tyr Tyr Val Lys Ser Tyr Lys Leu Glu Val Ser Thr Asn 
        355                 360                 365             


Gly Glu Asp Trp Met Val Tyr Arg His Gly Lys Asn His Lys Val Phe 
    370                 375                 380                 


Gln Ala Asn Asn Asp Ala Thr Glu Val Val Leu Asn Lys Leu His Ala 
385                 390                 395                 400 


Pro Leu Leu Thr Arg Phe Val Arg Ile Arg Pro Gln Thr Trp His Ser 
                405                 410                 415     


Gly Ile Ala Leu Arg Leu Glu Leu Phe Gly Cys Arg Val Thr Asp Ala 
            420                 425                 430         


Pro Cys Ser Asn Met Leu Gly Met Leu Ser Gly Leu Ile Ala Asp Ser 
        435                 440                 445             


Gln Ile Ser Ala Ser Ser Thr Gln Glu Tyr Leu Trp Ser Pro Ser Ala 
    450                 455                 460                 


Ala Arg Leu Val Ser Ser Arg Ser Gly Trp Phe Pro Arg Ile Pro Gln 
465                 470                 475                 480 


Ala Gln Pro Gly Glu Glu Trp Leu Gln Val Asp Leu Gly Thr Pro Lys 
                485                 490                 495     


Thr Val Lys Gly Val Ile Ile Gln Gly Ala Arg Gly Gly Asp Ser Ile 
            500                 505                 510         


Thr Ala Val Glu Ala Arg Ala Phe Val Arg Lys Phe Lys Val Ser Tyr 
        515                 520                 525             


Ser Leu Asn Gly Lys Asp Trp Glu Tyr Ile Gln Asp Pro Arg Thr Gln 
    530                 535                 540                 


Gln Pro Lys Leu Phe Glu Gly Asn Met His Tyr Asp Thr Pro Asp Ile 
545                 550                 555                 560 


Arg Arg Phe Asp Pro Ile Pro Ala Gln Tyr Val Arg Val Tyr Pro Glu 
                565                 570                 575     


Arg Trp Ser Pro Ala Gly Ile Gly Met Arg Leu Glu Val Leu Gly Cys 
            580                 585                 590         


Asp Trp Thr Asp Ser Lys Pro Thr Val Glu Thr Leu Gly Pro Thr Val 
        595                 600                 605             


Lys Ser Glu Glu Thr Thr Thr Pro Tyr Pro Thr Glu Glu Glu Ala Thr 
    610                 615                 620                 


Glu Cys Gly Glu Asn Cys Ser Phe Glu Asp Asp Lys Asp Leu Gln Leu 
625                 630                 635                 640 


Pro Ser Gly Phe Asn Cys Asn Phe Asp Phe Leu Glu Glu Pro Cys Gly 
                645                 650                 655     


Trp Met Tyr Asp His Ala Lys Trp Leu Arg Thr Thr Trp Ala Ser Ser 
            660                 665                 670         


Ser Ser Pro Asn Asp Arg Thr Phe Pro Asp Asp Arg Asn Phe Leu Arg 
        675                 680                 685             


Leu Gln Ser Asp Ser Gln Arg Glu Gly Gln Tyr Ala Arg Leu Ile Ser 
    690                 695                 700                 


Pro Pro Val His Leu Pro Arg Ser Pro Val Cys Met Glu Phe Gln Tyr 
705                 710                 715                 720 


Gln Ala Thr Gly Gly Arg Gly Val Ala Leu Gln Val Val Arg Glu Ala 
                725                 730                 735     


Ser Gln Glu Ser Lys Leu Leu Trp Val Ile Arg Glu Asp Gln Gly Gly 
            740                 745                 750         


Glu Trp Lys His Gly Arg Ile Ile Leu Pro Ser Tyr Asp Met Glu Tyr 
        755                 760                 765             


Gln Ile Val Phe Glu Gly Val Ile Gly Lys Gly Arg Ser Gly Glu Ile 
    770                 775                 780                 


Ala Ile Asp Asp Ile Arg Ile Ser Thr Asp Val Pro Leu Glu Asn Cys 
785                 790                 795                 800 


Met Glu Pro Ile Ser Ala Phe Ala Val Asp Ile Pro Glu Ile His Glu 
                805                 810                 815     


Arg Glu Gly Tyr Glu Asp Glu Ile Asp Asp Glu Tyr Glu Val Asp Trp 
            820                 825                 830         


Ser Asn Ser Ser Ser Ala Thr Ser Gly Ser Gly Ala Pro Ser Thr Asp 
        835                 840                 845             


Lys Glu Lys Ser Trp Leu Tyr Thr Leu Asp Pro Ile Leu Ile Thr Ile 
    850                 855                 860                 


Ile Ala Met Ser Ser Leu Gly Val Leu Leu Gly Ala Thr Cys Ala Gly 
865                 870                 875                 880 


Leu Leu Leu Tyr Cys Thr Cys Ser Tyr Ser Gly Leu Ser Ser Arg Ser 
                885                 890                 895     


Cys Thr Thr Leu Glu Asn Tyr Asn Phe Glu Leu Tyr Asp Gly Leu Lys 
            900                 905                 910         


His Lys Val Lys Met Asn His Gln Lys Cys Cys Ser Glu Ala 
        915                 920                 925     


<210>  12
<211>  2775
<212>  DNA
<213>  Homo sapiens

<400>  12
atgtttcctc tcacctgggt tttcttagcc ctctactttt caagacacca agtgagaggc       60

caaccagacc caccgtgcgg aggtcgtttg aattccaaag atgctggcta tatcacctct      120

cccggttacc cccaggacta cccctcccac cagaactgcg agtggattgt ttacgccccc      180

gaacccaacc agaagattgt cctcaacttc aaccctcact ttgaaatcga gaagcacgac      240

tgcaagtatg actttatcga gattcgggat ggggacagtg aatccgcaga cctcctgggc      300

aaacactgtg ggaacatcgc cccgcccacc atcatctcct cgggctccat gctctacatc      360

aagttcacct ccgactacgc ccggcagggg gcaggcttct ctctgcgcta cgagatcttc      420

aagacaggct ctgaagattg ctcaaaaaac ttcacaagcc ccaacgggac catcgaatct      480

cctgggtttc ctgagaagta tccacacaac ttggactgca cctttaccat cctggccaaa      540

cccaagatgg agatcatcct gcagttcctg atctttgacc tggagcatga ccctttgcag      600

gtgggagagg gggactgcaa gtacgattgg ctggacatct gggatggcat tccacatgtt      660

ggccccctga ttggcaagta ctgtgggacc aaaacaccct ctgaacttcg ttcatcgacg      720

gggatcctct ccctgacctt tcacacggac atggcggtgg ccaaggatgg cttctctgcg      780

cgttactacc tggtccacca agagccacta gagaactttc agtgcaatgt tcctctgggc      840

atggagtctg gccggattgc taatgaacag atcagtgcct catctaccta ctctgatggg      900

aggtggaccc ctcaacaaag ccggctccat ggtgatgaca atggctggac ccccaacttg      960

gattccaaca aggagtatct ccaggtggac ctgcgctttt taaccatgct cacggccatc     1020

gcaacacagg gagcgatttc cagggaaaca cagaatggct actatgtcaa atcctacaag     1080

ctggaagtca gcactaatgg agaggactgg atggtgtacc ggcatggcaa aaaccacaag     1140

gtatttcaag ccaacaacga tgcaactgag gtggttctga acaagctcca cgctccactg     1200

ctgacaaggt ttgttagaat ccgccctcag acctggcact caggtatcgc cctccggctg     1260

gagctcttcg gctgccgggt cacagatgct ccctgctcca acatgctggg gatgctctca     1320

ggcctcattg cagactccca gatctccgcc tcttccaccc aggaatacct ctggagcccc     1380

agtgcagccc gcctggtcag cagccgctcg ggctggttcc ctcgaatccc tcaggcccag     1440

cccggtgagg agtggcttca ggtagatctg ggaacaccca agacagtgaa aggtgtcatc     1500

atccagggag cccgcggagg agacagtatc actgctgtgg aagccagagc atttgtgcgc     1560

aagttcaaag tctcctacag cctaaacggc aaggactggg aatacattca ggaccccagg     1620

acccagcagc caaagctgtt cgaagggaac atgcactatg acacccctga catccgaagg     1680

tttgacccca ttccggcaca gtatgtgcgg gtatacccgg agaggtggtc gccggcgggg     1740

attgggatgc ggctggaggt gctgggctgt gactggacag actccaagcc cacggtagag     1800

acgctgggac ccactgtgaa gagcgaagag acaaccaccc cctaccccac cgaagaggag     1860

gccacagagt gtggggagaa ctgcagcttt gaggatgaca aagatttgca gctcccttcg     1920

ggattcaatt gcaacttcga tttcctcgag gagccctgtg gttggatgta tgaccatgcc     1980

aagtggctcc ggaccacctg ggccagcagc tccagcccaa acgaccggac gtttccagat     2040

gacaggaatt tcttgcggct gcagagtgac agccagagag agggccagta tgcccggctc     2100

atcagccccc ctgtccacct gccccgaagc ccggtgtgca tggagttcca gtaccaggcc     2160

acgggcggcc gcggggtggc gctgcaggtg gtgcgggaag ccagccagga gagcaagttg     2220

ctgtgggtca tccgtgagga ccagggcggc gagtggaagc acgggcggat catcctgccc     2280

agctacgaca tggagtacca gattgtgttc gagggagtga tagggaaagg acgttccgga     2340

gagattgcca ttgatgacat tcggataagc actgatgtcc cactggagaa ctgcatggaa     2400

cccatctcgg cttttgcagt ggacatccca gaaatacatg agagagaagg atatgaagat     2460

gaaattgatg atgaatacga ggtggactgg agcaattctt cttctgcaac ctcagggtct     2520

ggcgccccct cgaccgacaa agaaaagagc tggctgtaca ccctggatcc catcctcatc     2580

accatcatcg ccatgagctc actgggcgtc ctcctggggg ccacctgtgc aggcctcctg     2640

ctctactgca cctgttccta ctcgggcctg agctcccgaa gctgcaccac actggagaac     2700

tacaacttcg agctctacga tggccttaag cacaaggtca agatgaacca ccaaaagtgc     2760

tgctccgagg catga                                                      2775


<210>  13
<211>  289
<212>  PRT
<213>  Homo sapiens

<400>  13

Met Lys Thr Leu Pro Ala Met Leu Gly Thr Gly Lys Leu Phe Trp Val 
1               5                   10                  15      


Phe Phe Leu Ile Pro Tyr Leu Asp Ile Trp Asn Ile His Gly Lys Glu 
            20                  25                  30          


Ser Cys Asp Val Gln Leu Tyr Ile Lys Arg Gln Ser Glu His Ser Ile 
        35                  40                  45              


Leu Ala Gly Asp Pro Phe Glu Leu Glu Cys Pro Val Lys Tyr Cys Ala 
    50                  55                  60                  


Asn Arg Pro His Val Thr Trp Cys Lys Leu Asn Gly Thr Thr Cys Val 
65                  70                  75                  80  


Lys Leu Glu Asp Arg Gln Thr Ser Trp Lys Glu Glu Lys Asn Ile Ser 
                85                  90                  95      


Phe Phe Ile Leu His Phe Glu Pro Val Leu Pro Asn Asp Asn Gly Ser 
            100                 105                 110         


Tyr Arg Cys Ser Ala Asn Phe Gln Ser Asn Leu Ile Glu Ser His Ser 
        115                 120                 125             


Thr Thr Leu Tyr Val Thr Asp Val Lys Ser Ala Ser Glu Arg Pro Ser 
    130                 135                 140                 


Lys Asp Glu Met Ala Ser Arg Pro Trp Leu Leu Tyr Arg Leu Leu Pro 
145                 150                 155                 160 


Leu Gly Gly Leu Pro Leu Leu Ile Thr Thr Cys Phe Cys Leu Phe Cys 
                165                 170                 175     


Cys Leu Arg Arg His Gln Gly Lys Gln Asn Glu Leu Ser Asp Thr Ala 
            180                 185                 190         


Gly Arg Glu Ile Asn Leu Val Asp Ala His Leu Lys Ser Glu Gln Thr 
        195                 200                 205             


Glu Ala Ser Thr Arg Gln Asn Ser Gln Val Leu Leu Ser Glu Thr Gly 
    210                 215                 220                 


Ile Tyr Asp Asn Asp Pro Asp Leu Cys Phe Arg Met Gln Glu Gly Ser 
225                 230                 235                 240 


Glu Val Tyr Ser Asn Pro Cys Leu Glu Glu Asn Lys Pro Gly Ile Val 
                245                 250                 255     


Tyr Ala Ser Leu Asn His Ser Val Ile Gly Pro Asn Ser Arg Leu Ala 
            260                 265                 270         


Arg Asn Val Lys Glu Ala Pro Thr Glu Tyr Ala Ser Ile Cys Val Arg 
        275                 280                 285             


Ser 
    


<210>  14
<211>  726
<212>  DNA
<213>  Homo sapiens

<400>  14
atgaagacat tgcctgccat gcttggaact gggaaattat tttgggtctt cttcttaatc       60

ccatatctgg acatctggaa catccatggg aaagaatcat gtgatgtaca gctttatata      120

aagagacaat ctgaacactc catcttagca ggagatccct ttgaactaga atgccctgtg      180

aaatactgtg ctaacaggcc tcatgtgact tggtgcaagc tcaatggaac aacatgtgta      240

aaacttgaag atagacaaac aagttggaag gaagagaaga acatttcatt tttcattcta      300

cattttgaac cagtgcttcc taatgacaat gggtcatacc gctgttctgc aaattttcag      360

tctaatctca ttgaaagcca ctcaacaact ctttatgtga caggaaagca aaatgaactc      420

tctgacacag caggaaggga aattaacctg gttgatgctc accttaagag tgagcaaaca      480

gaagcaagca ccaggcaaaa ttcccaagta ctgctatcag aaactggaat ttatgataat      540

gaccctgacc tttgtttcag gatgcaggaa gggtctgaag tttattctaa tccatgcctg      600

gaagaaaaca aaccaggcat tgtttatgct tccctgaacc attctgtcat tggaccgaac      660

tcaagactgg caagaaatgt aaaagaagca ccaacagaat atgcatccat atgtgtgagg      720

agttaa                                                                 726


