                         SEQUENCE LISTING

<110>  TUSK THERAPEUTICS LTD
 
<120>  CD38 MODULATING ANTIBODY

<130>  P114629WO

<160>  77    

<170>  PatentIn version 3.5

<210>  1
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  1

Gly Ser Ile Ser Ser Gly Ser Tyr Tyr Trp Ser 
1               5                   10      


<210>  2
<211>  16
<212>  PRT
<213>  Homo sapiens

<400>  2

Tyr Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 
1               5                   10                  15      


<210>  3
<211>  16
<212>  PRT
<213>  Homo sapiens

<400>  3

Ala Arg Gly Ser Pro Tyr Arg Trp Tyr Asn Tyr Tyr Tyr Met Asp Val 
1               5                   10                  15      


<210>  4
<211>  98
<212>  PRT
<213>  Homo sapiens


<220>
<221>  HCDR1
<222>  (1)..(11)

<220>
<221>  HCDR2
<222>  (26)..(41)

<220>
<221>  HCDR3
<222>  (72)..(87)

<400>  4

Gly Ser Ile Ser Ser Gly Ser Tyr Tyr Trp Ser Trp Ile Arg Gln His 
1               5                   10                  15      


Pro Gly Lys Gly Leu Glu Trp Ile Gly Tyr Ile Tyr Tyr Ser Gly Ser 
            20                  25                  30          


Thr Tyr Tyr Asn Pro Ser Leu Lys Ser Arg Val Thr Ile Ser Val Asp 
        35                  40                  45              


Thr Ser Lys Asn Gln Phe Ser Leu Lys Leu Ser Ser Val Thr Ala Ala 
    50                  55                  60                  


Asp Thr Ala Val Tyr Tyr Cys Ala Arg Gly Ser Pro Tyr Arg Trp Tyr 
65                  70                  75                  80  


Asn Tyr Tyr Tyr Met Asp Val Trp Gly Lys Gly Thr Thr Val Thr Val 
                85                  90                  95      


Ser Ser 
        


<210>  5
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  5

Arg Ala Ser Gln Ser Ile Ser Ser Trp Leu Ala 
1               5                   10      


<210>  6
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  6

Asp Ala Ser Ser Leu Glu Ser 
1               5           


<210>  7
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  7

Gln Gln His Arg Ser Tyr Pro Pro Thr 
1               5                   


<210>  8
<211>  84
<212>  PRT
<213>  Homo sapiens


<220>
<221>  LCDR1
<222>  (1)..(11)

<220>
<221>  LCDR2
<222>  (27)..(33)

<220>
<221>  LCDR3
<222>  (66)..(74)

<400>  8

Arg Ala Ser Gln Ser Ile Ser Ser Trp Leu Ala Trp Tyr Gln Gln Lys 
1               5                   10                  15      


Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Asp Ala Ser Ser Leu Glu 
            20                  25                  30          


Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe 
        35                  40                  45              


Thr Leu Thr Ile Ser Ser Leu Gln Pro Asp Asp Phe Ala Thr Tyr Tyr 
    50                  55                  60                  


Cys Gln Gln His Arg Ser Tyr Pro Pro Thr Phe Gly Gly Gly Thr Lys 
65                  70                  75                  80  


Val Glu Ile Lys 
                


<210>  9
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  9

Tyr Thr Phe Thr Gly Tyr Tyr Met His 
1               5                   


<210>  10
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  10

Trp Ile Asn Pro Asn Ser Gly Gly Thr Asn Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  11
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  11

Ala Arg Asp Gln Ala His Gln Arg Ser Ser Tyr Asp 
1               5                   10          


<210>  12
<211>  93
<212>  PRT
<213>  Homo sapiens


<220>
<221>  HCDR1
<222>  (1)..(9)

<220>
<221>  HCDR2
<222>  (24)..(40)

<220>
<221>  HCDR3
<222>  (71)..(82)

<400>  12

Tyr Thr Phe Thr Gly Tyr Tyr Met His Trp Val Arg Gln Ala Pro Gly 
1               5                   10                  15      


Gln Gly Leu Glu Trp Met Gly Trp Ile Asn Pro Asn Ser Gly Gly Thr 
            20                  25                  30          


Asn Tyr Ala Gln Lys Phe Gln Gly Arg Val Thr Met Thr Arg Asp Thr 
        35                  40                  45              


Ser Ile Ser Thr Ala Tyr Met Glu Leu Ser Arg Leu Arg Ser Asp Asp 
    50                  55                  60                  


Thr Ala Val Tyr Tyr Cys Ala Arg Asp Gln Ala His Gln Arg Ser Ser 
65                  70                  75                  80  


Tyr Asp Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
                85                  90              


<210>  13
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  13

Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn 
1               5                   10      


<210>  14
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  14

Gly Ala Ser Ser Leu Gln Ser 
1               5           


<210>  15
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  15

Gln Gln Arg Ser Ser Thr Pro Ile Thr 
1               5                   


<210>  16
<211>  84
<212>  PRT
<213>  Homo sapiens


<220>
<221>  LCDR1
<222>  (1)..(11)

<220>
<221>  LCDR2
<222>  (27)..(33)

<220>
<221>  LCDR3
<222>  (66)..(74)

<400>  16

Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn Trp Tyr Gln Gln Lys 
1               5                   10                  15      


Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Gly Ala Ser Ser Leu Gln 
            20                  25                  30          


Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 
        35                  40                  45              


Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr 
    50                  55                  60                  


Cys Gln Gln Arg Ser Ser Thr Pro Ile Thr Phe Gly Gly Gly Thr Lys 
65                  70                  75                  80  


Val Glu Ile Lys 
                


<210>  17
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  17

Gly Ser Ile Ser Ser Ser Asp Tyr Tyr Trp Gly 
1               5                   10      


<210>  18
<211>  16
<212>  PRT
<213>  Homo sapiens

<400>  18

Ser Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 
1               5                   10                  15      


<210>  19
<211>  16
<212>  PRT
<213>  Homo sapiens

<400>  19

Ala Arg Gly Gln Tyr Ser Ser Gly Trp Tyr Ala Tyr Pro Phe Asp Met 
1               5                   10                  15      


<210>  20
<211>  87
<212>  PRT
<213>  Homo sapiens


<220>
<221>  HCDR1
<222>  (1)..(11)

<220>
<221>  HCDR2
<222>  (26)..(41)

<220>
<221>  HCDR3
<222>  (72)..(87)

<400>  20

Gly Ser Ile Ser Ser Ser Asp Tyr Tyr Trp Gly Trp Ile Arg Gln Pro 
1               5                   10                  15      


Pro Gly Lys Gly Leu Glu Trp Ile Gly Ser Ile Tyr Tyr Ser Gly Ser 
            20                  25                  30          


Thr Tyr Tyr Asn Pro Ser Leu Lys Ser Arg Val Thr Ile Ser Val Asp 
        35                  40                  45              


Thr Ser Lys Asn Gln Phe Ser Leu Lys Leu Ser Ser Val Thr Ala Ala 
    50                  55                  60                  


Asp Thr Ala Val Tyr Tyr Cys Ala Arg Gly Gln Tyr Ser Ser Gly Trp 
65                  70                  75                  80  


Tyr Ala Tyr Pro Phe Asp Met 
                85          


<210>  21
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  21

Arg Ala Ser Gln Ser Val Arg Ser Ser Tyr Leu Ala 
1               5                   10          


<210>  22
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  22

Gly Ala Ser Ser Arg Ala Thr 
1               5           


<210>  23
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  23

Gln Gln Asp Gly Ala Val Phe Thr 
1               5               


<210>  24
<211>  74
<212>  PRT
<213>  Homo sapiens


<220>
<221>  LCDR1
<222>  (1)..(12)

<220>
<221>  LCDR2
<222>  (28)..(34)

<220>
<221>  LCDR3
<222>  (67)..(74)

<400>  24

Arg Ala Ser Gln Ser Val Arg Ser Ser Tyr Leu Ala Trp Tyr Gln Gln 
1               5                   10                  15      


Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr Gly Ala Ser Ser Arg 
            20                  25                  30          


Ala Thr Gly Ile Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp 
        35                  40                  45              


Phe Thr Leu Thr Ile Ser Arg Leu Glu Pro Glu Asp Phe Ala Val Tyr 
    50                  55                  60                  


Tyr Cys Gln Gln Asp Gly Ala Val Phe Thr 
65                  70                  


<210>  25
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  25

Gly Ser Ile Ser Ser Ser Asp Tyr Tyr Trp Gly 
1               5                   10      


<210>  26
<211>  16
<212>  PRT
<213>  Homo sapiens

<400>  26

Ser Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 
1               5                   10                  15      


<210>  27
<211>  16
<212>  PRT
<213>  Homo sapiens

<400>  27

Ala Arg Gly Gln Tyr Ser Ser Gly Trp Tyr Ala Tyr Pro Phe Asp Met 
1               5                   10                  15      


<210>  28
<211>  87
<212>  PRT
<213>  Homo sapiens


<220>
<221>  HCDR1
<222>  (1)..(11)

<220>
<221>  HCDR2
<222>  (26)..(41)

<220>
<221>  HCDR3
<222>  (72)..(87)

<400>  28

Gly Ser Ile Ser Ser Ser Asp Tyr Tyr Trp Gly Trp Ile Arg Gln Pro 
1               5                   10                  15      


Pro Gly Lys Gly Leu Glu Trp Ile Gly Ser Ile Tyr Tyr Ser Gly Ser 
            20                  25                  30          


Thr Tyr Tyr Asn Pro Ser Leu Lys Ser Arg Val Thr Ile Ser Val Asp 
        35                  40                  45              


Thr Ser Lys Asn Gln Phe Ser Leu Lys Leu Ser Ser Val Thr Ala Ala 
    50                  55                  60                  


Asp Thr Ala Val Tyr Tyr Cys Ala Arg Gly Gln Tyr Ser Ser Gly Trp 
65                  70                  75                  80  


Tyr Ala Tyr Pro Phe Asp Met 
                85          


<210>  29
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  29

Arg Ala Ser Gln Ser Val Arg Ser Ser Tyr Leu Ala 
1               5                   10          


<210>  30
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  30

Gly Ala Ser Ser Arg Ala Thr 
1               5           


<210>  31
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  31

Gln Gln Asp Gly Asn Val Tyr Thr 
1               5               


<210>  32
<211>  74
<212>  PRT
<213>  Homo sapiens


<220>
<221>  LCDR1
<222>  (1)..(12)

<220>
<221>  LCDR2
<222>  (28)..(34)

<220>
<221>  LCDR3
<222>  (67)..(74)

<400>  32

Arg Ala Ser Gln Ser Val Arg Ser Ser Tyr Leu Ala Trp Tyr Gln Gln 
1               5                   10                  15      


Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr Gly Ala Ser Ser Arg 
            20                  25                  30          


Ala Thr Gly Ile Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp 
        35                  40                  45              


Phe Thr Leu Thr Ile Ser Arg Leu Glu Pro Glu Asp Phe Ala Val Tyr 
    50                  55                  60                  


Tyr Cys Gln Gln Asp Gly Asn Val Tyr Thr 
65                  70                  


<210>  33
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  33

Gly Ser Ile Ser Ser Gly Gly Tyr Tyr Trp Ser 
1               5                   10      


<210>  34
<211>  16
<212>  PRT
<213>  Homo sapiens

<400>  34

Tyr Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 
1               5                   10                  15      


<210>  35
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  35

Ala Arg Ala Lys Ser Glu Leu Val Leu Pro Tyr Tyr Tyr Tyr Met Asp 
1               5                   10                  15      


Val 
    


<210>  36
<211>  99
<212>  PRT
<213>  Homo sapiens


<220>
<221>  HCDR1
<222>  (1)..(11)

<220>
<221>  HCDR2
<222>  (26)..(41)

<220>
<221>  HCDR3
<222>  (72)..(88)

<400>  36

Gly Ser Ile Ser Ser Gly Gly Tyr Tyr Trp Ser Trp Ile Arg Gln His 
1               5                   10                  15      


Pro Gly Lys Gly Leu Glu Trp Ile Gly Tyr Ile Tyr Tyr Ser Gly Ser 
            20                  25                  30          


Thr Tyr Tyr Asn Pro Ser Leu Lys Ser Arg Val Thr Ile Ser Val Asp 
        35                  40                  45              


Thr Ser Lys Asn Gln Phe Ser Leu Lys Leu Ser Ser Val Thr Ala Ala 
    50                  55                  60                  


Asp Thr Ala Val Tyr Tyr Cys Ala Arg Ala Lys Ser Glu Leu Val Leu 
65                  70                  75                  80  


Pro Tyr Tyr Tyr Tyr Met Asp Val Trp Gly Lys Gly Thr Thr Val Thr 
                85                  90                  95      


Val Ser Ser 
            


<210>  37
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  37

Lys Ser Ser Gln Ser Val Leu Phe Ser Ser Asn Asn Lys Asn Tyr Leu 
1               5                   10                  15      


Ala 
    


<210>  38
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  38

Trp Ala Ser Thr Arg Glu Ser 
1               5           


<210>  39
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  39

Gln Gln Tyr Tyr Ser Leu Pro Pro Thr 
1               5                   


<210>  40
<211>  90
<212>  PRT
<213>  Homo sapiens


<220>
<221>  LCDR1
<222>  (1)..(17)

<220>
<221>  LCDR2
<222>  (33)..(39)

<220>
<221>  LCDR3
<222>  (72)..(80)

<400>  40

Lys Ser Ser Gln Ser Val Leu Phe Ser Ser Asn Asn Lys Asn Tyr Leu 
1               5                   10                  15      


Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile Tyr 
            20                  25                  30          


Trp Ala Ser Thr Arg Glu Ser Gly Val Pro Asp Arg Phe Ser Gly Ser 
        35                  40                  45              


Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Ala Glu 
    50                  55                  60                  


Asp Val Ala Val Tyr Tyr Cys Gln Gln Tyr Tyr Ser Leu Pro Pro Thr 
65                  70                  75                  80  


Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
                85                  90  


<210>  41
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  41

Gln Gln Asp Glu Ala Val Phe Thr 
1               5               


<210>  42
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  42

Gln Gln Asp Ser Ala Val Phe Thr 
1               5               


<210>  43
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  43

Gln Gln Glu Ala Asn Val Tyr Thr 
1               5               


<210>  44
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  44

Gln Gln Asp Ser Asn Val Tyr Thr 
1               5               


<210>  45
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  45

Gln Gln Asp Ala Asn Val Tyr Thr 
1               5               


<210>  46
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  46

Gln Gln Glu Gly Asn Val Tyr Thr 
1               5               


<210>  47
<211>  300
<212>  PRT
<213>  Homo sapiens

<400>  47

Met Ala Asn Cys Glu Phe Ser Pro Val Ser Gly Asp Lys Pro Cys Cys 
1               5                   10                  15      


Arg Leu Ser Arg Arg Ala Gln Leu Cys Leu Gly Val Ser Ile Leu Val 
            20                  25                  30          


Leu Ile Leu Val Val Val Leu Ala Val Val Val Pro Arg Trp Arg Gln 
        35                  40                  45              


Gln Trp Ser Gly Pro Gly Thr Thr Lys Arg Phe Pro Glu Thr Val Leu 
    50                  55                  60                  


Ala Arg Cys Val Lys Tyr Thr Glu Ile His Pro Glu Met Arg His Val 
65                  70                  75                  80  


Asp Cys Gln Ser Val Trp Asp Ala Phe Lys Gly Ala Phe Ile Ser Lys 
                85                  90                  95      


His Pro Cys Asn Ile Thr Glu Glu Asp Tyr Gln Pro Leu Met Lys Leu 
            100                 105                 110         


Gly Thr Gln Thr Val Pro Cys Asn Lys Ile Leu Leu Trp Ser Arg Ile 
        115                 120                 125             


Lys Asp Leu Ala His Gln Phe Thr Gln Val Gln Arg Asp Met Phe Thr 
    130                 135                 140                 


Leu Glu Asp Thr Leu Leu Gly Tyr Leu Ala Asp Asp Leu Thr Trp Cys 
145                 150                 155                 160 


Gly Glu Phe Asn Thr Ser Lys Ile Asn Tyr Gln Ser Cys Pro Asp Trp 
                165                 170                 175     


Arg Lys Asp Cys Ser Asn Asn Pro Val Ser Val Phe Trp Lys Thr Val 
            180                 185                 190         


Ser Arg Arg Phe Ala Glu Ala Ala Cys Asp Val Val His Val Met Leu 
        195                 200                 205             


Asn Gly Ser Arg Ser Lys Ile Phe Asp Lys Asn Ser Thr Phe Gly Ser 
    210                 215                 220                 


Val Glu Val His Asn Leu Gln Pro Glu Lys Val Gln Thr Leu Glu Ala 
225                 230                 235                 240 


Trp Val Ile His Gly Gly Arg Glu Asp Ser Arg Asp Leu Cys Gln Asp 
                245                 250                 255     


Pro Thr Ile Lys Glu Leu Glu Ser Ile Ile Ser Lys Arg Asn Ile Gln 
            260                 265                 270         


Phe Ser Cys Lys Asn Ile Tyr Arg Pro Asp Lys Phe Leu Gln Cys Val 
        275                 280                 285             


Lys Asn Pro Glu Asp Ser Ser Cys Thr Ser Glu Ile 
    290                 295                 300 


<210>  48
<211>  124
<212>  PRT
<213>  Homo sapiens


<220>
<221>  HCDR1
<222>  (27)..(37)

<220>
<221>  HCDR2
<222>  (52)..(67)

<220>
<221>  HCDR3
<222>  (98)..(113)

<400>  48

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Gly 
            20                  25                  30          


Ser Tyr Tyr Trp Ser Trp Ile Arg Gln His Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Tyr Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Gly Ser Pro Tyr Arg Trp Tyr Asn Tyr Tyr Tyr Met Asp 
            100                 105                 110         


Val Trp Gly Lys Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 


<210>  49
<211>  107
<212>  PRT
<213>  Homo sapiens


<220>
<221>  LCDR1
<222>  (24)..(34)

<220>
<221>  LCDR2
<222>  (50)..(56)

<220>
<221>  LCDR3
<222>  (89)..(97)

<400>  49

Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln His Arg Ser Tyr Pro Pro 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  50
<211>  119
<212>  PRT
<213>  Homo sapiens


<220>
<221>  HCDR1
<222>  (27)..(35)

<220>
<221>  HCDR2
<222>  (50)..(66)

<220>
<221>  HCDR3
<222>  (97)..(108)

<400>  50

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Gly Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Pro Asn Ser Gly Gly Thr Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gln Ala His Gln Arg Ser Ser Tyr Asp Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  51
<211>  107
<212>  PRT
<213>  Homo sapiens


<220>
<221>  LCDR1
<222>  (24)..(34)

<220>
<221>  LCDR2
<222>  (50)..(56)

<220>
<221>  LCDR3
<222>  (89)..(97)

<400>  51

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Gly Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Arg Ser Ser Thr Pro Ile 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  52
<211>  124
<212>  PRT
<213>  Homo sapiens


<220>
<221>  HCDR1
<222>  (27)..(37)

<220>
<221>  HCDR2
<222>  (52)..(67)

<220>
<221>  HCDR3
<222>  (98)..(113)

<400>  52

Gln Leu Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Ser 
            20                  25                  30          


Asp Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Ser Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Gly Gln Tyr Ser Ser Gly Trp Tyr Ala Tyr Pro Phe Asp 
            100                 105                 110         


Met Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120                 


<210>  53
<211>  107
<212>  PRT
<213>  Homo sapiens


<220>
<221>  LCDR1
<222>  (24)..(35)

<220>
<221>  LCDR2
<222>  (51)..(57)

<220>
<221>  LCDR3
<222>  (90)..(97)

<400>  53

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Arg Ser Ser 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Asp Gly Ala Val Phe 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  54
<211>  124
<212>  PRT
<213>  Homo sapiens


<220>
<221>  HCDR1
<222>  (27)..(37)

<220>
<221>  HCDR2
<222>  (52)..(67)

<220>
<221>  HCDR3
<222>  (98)..(113)

<400>  54

Gln Leu Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Ser 
            20                  25                  30          


Asp Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Ser Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Gly Gln Tyr Ser Ser Gly Trp Tyr Ala Tyr Pro Phe Asp 
            100                 105                 110         


Met Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120                 


<210>  55
<211>  107
<212>  PRT
<213>  Homo sapiens


<220>
<221>  LCDR1
<222>  (24)..(35)

<220>
<221>  LCDR2
<222>  (51)..(57)

<220>
<221>  LCDR3
<222>  (90)..(107)

<400>  55

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Arg Ser Ser 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Asp Gly Asn Val Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  56
<211>  125
<212>  PRT
<213>  Homo sapiens


<220>
<221>  HCDR1
<222>  (27)..(36)

<220>
<221>  HCDR2
<222>  (52)..(67)

<220>
<221>  HCDR3
<222>  (98)..(114)

<400>  56

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Gly 
            20                  25                  30          


Gly Tyr Tyr Trp Ser Trp Ile Arg Gln His Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Tyr Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Ala Lys Ser Glu Leu Val Leu Pro Tyr Tyr Tyr Tyr Met 
            100                 105                 110         


Asp Val Trp Gly Lys Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 125 


<210>  57
<211>  113
<212>  PRT
<213>  Homo sapiens


<220>
<221>  LCDR1
<222>  (24)..(40)

<220>
<221>  LCDR2
<222>  (56)..(62)

<220>
<221>  LCDR3
<222>  (95)..(103)

<400>  57

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Val Leu Phe Ser 
            20                  25                  30          


Ser Asn Asn Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln 
                85                  90                  95      


Tyr Tyr Ser Leu Pro Pro Thr Phe Gly Gly Gly Thr Lys Val Glu Ile 
            100                 105                 110         


Lys 
    


<210>  58
<211>  74
<212>  PRT
<213>  Homo sapiens


<220>
<221>  LCDR1
<222>  (1)..(12)

<220>
<221>  LCDR2
<222>  (28)..(34)

<220>
<221>  LCDR3
<222>  (67)..(74)

<400>  58

Arg Ala Ser Gln Ser Val Arg Ser Ser Tyr Leu Ala Trp Tyr Gln Gln 
1               5                   10                  15      


Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr Gly Ala Ser Ser Arg 
            20                  25                  30          


Ala Thr Gly Ile Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp 
        35                  40                  45              


Phe Thr Leu Thr Ile Ser Arg Leu Glu Pro Glu Asp Phe Ala Val Tyr 
    50                  55                  60                  


Tyr Cys Gln Gln Glu Ala Asn Val Tyr Thr 
65                  70                  


<210>  59
<211>  74
<212>  PRT
<213>  Homo sapiens


<220>
<221>  LCDR1
<222>  (1)..(12)

<220>
<221>  LCDR2
<222>  (28)..(34)

<220>
<221>  LCDR3
<222>  (67)..(74)

<400>  59

Arg Ala Ser Gln Ser Val Arg Ser Ser Tyr Leu Ala Trp Tyr Gln Gln 
1               5                   10                  15      


Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr Gly Ala Ser Ser Arg 
            20                  25                  30          


Ala Thr Gly Ile Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp 
        35                  40                  45              


Phe Thr Leu Thr Ile Ser Arg Leu Glu Pro Glu Asp Phe Ala Val Tyr 
    50                  55                  60                  


Tyr Cys Gln Gln Asp Ser Asn Val Tyr Thr 
65                  70                  


<210>  60
<211>  74
<212>  PRT
<213>  Homo sapiens


<220>
<221>  LCDR1
<222>  (1)..(12)

<220>
<221>  LCDR2
<222>  (28)..(34)

<220>
<221>  LCDR3
<222>  (67)..(74)

<400>  60

Arg Ala Ser Gln Ser Val Arg Ser Ser Tyr Leu Ala Trp Tyr Gln Gln 
1               5                   10                  15      


Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr Gly Ala Ser Ser Arg 
            20                  25                  30          


Ala Thr Gly Ile Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp 
        35                  40                  45              


Phe Thr Leu Thr Ile Ser Arg Leu Glu Pro Glu Asp Phe Ala Val Tyr 
    50                  55                  60                  


Tyr Cys Gln Gln Asp Ala Asn Val Tyr Thr 
65                  70                  


<210>  61
<211>  74
<212>  PRT
<213>  Homo sapiens


<220>
<221>  LCDR1
<222>  (1)..(12)

<220>
<221>  LCDR2
<222>  (28)..(34)

<220>
<221>  LCDR3
<222>  (67)..(74)

<400>  61

Arg Ala Ser Gln Ser Val Arg Ser Ser Tyr Leu Ala Trp Tyr Gln Gln 
1               5                   10                  15      


Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr Gly Ala Ser Ser Arg 
            20                  25                  30          


Ala Thr Gly Ile Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp 
        35                  40                  45              


Phe Thr Leu Thr Ile Ser Arg Leu Glu Pro Glu Asp Phe Ala Val Tyr 
    50                  55                  60                  


Tyr Cys Gln Gln Glu Gly Asn Val Tyr Thr 
65                  70                  


<210>  62
<211>  74
<212>  PRT
<213>  Homo sapiens


<220>
<221>  LCDR1
<222>  (1)..(12)

<220>
<221>  LCDR2
<222>  (28)..(34)

<220>
<221>  LCDR3
<222>  (67)..(74)

<400>  62

Arg Ala Ser Gln Ser Val Arg Ser Ser Tyr Leu Ala Trp Tyr Gln Gln 
1               5                   10                  15      


Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr Gly Ala Ser Ser Arg 
            20                  25                  30          


Ala Thr Gly Ile Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp 
        35                  40                  45              


Phe Thr Leu Thr Ile Ser Arg Leu Glu Pro Glu Asp Phe Ala Val Tyr 
    50                  55                  60                  


Tyr Cys Gln Gln Asp Glu Ala Val Phe Thr 
65                  70                  


<210>  63
<211>  74
<212>  PRT
<213>  Homo sapiens


<220>
<221>  LCDR1
<222>  (1)..(12)

<220>
<221>  LCDR2
<222>  (28)..(34)

<220>
<221>  LCDR3
<222>  (67)..(74)

<400>  63

Arg Ala Ser Gln Ser Val Arg Ser Ser Tyr Leu Ala Trp Tyr Gln Gln 
1               5                   10                  15      


Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr Gly Ala Ser Ser Arg 
            20                  25                  30          


Ala Thr Gly Ile Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp 
        35                  40                  45              


Phe Thr Leu Thr Ile Ser Arg Leu Glu Pro Glu Asp Phe Ala Val Tyr 
    50                  55                  60                  


Tyr Cys Gln Gln Asp Ser Ala Val Phe Thr 
65                  70                  


<210>  64
<211>  107
<212>  PRT
<213>  Homo sapiens


<220>
<221>  LCDR1
<222>  (24)..(35)

<220>
<221>  LCDR2
<222>  (51)..(57)

<220>
<221>  LCDR3
<222>  (90)..(97)

<400>  64

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Arg Ser Ser 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Glu Ala Asn Val Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  65
<211>  107
<212>  PRT
<213>  Homo sapiens


<220>
<221>  LCDR1
<222>  (24)..(35)

<220>
<221>  LCDR2
<222>  (51)..(57)

<220>
<221>  LCDR3
<222>  (90)..(97)

<400>  65

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Arg Ser Ser 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Asp Ser Asn Val Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  66
<211>  107
<212>  PRT
<213>  Homo sapiens


<220>
<221>  LCDR1
<222>  (24)..(35)

<220>
<221>  LCDR2
<222>  (51)..(57)

<220>
<221>  LCDR3
<222>  (90)..(97)

<400>  66

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Arg Ser Ser 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Asp Ala Asn Val Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  67
<211>  107
<212>  PRT
<213>  Homo sapiens


<220>
<221>  LCDR1
<222>  (24)..(35)

<220>
<221>  LCDR2
<222>  (51)..(57)

<220>
<221>  LCDR3
<222>  (90)..(97)

<400>  67

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Arg Ser Ser 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Glu Gly Asn Val Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  68
<211>  107
<212>  PRT
<213>  Homo sapiens


<220>
<221>  LCDR1
<222>  (24)..(35)

<220>
<221>  LCDR2
<222>  (51)..(57)

<220>
<221>  LCDR3
<222>  (90)..(97)

<400>  68

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Arg Ser Ser 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Asp Glu Ala Val Phe 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  69
<211>  107
<212>  PRT
<213>  Homo sapiens


<220>
<221>  LCDR1
<222>  (24)..(35)

<220>
<221>  LCDR2
<222>  (51)..(57)

<220>
<221>  LCDR3
<222>  (90)..(97)

<400>  69

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Arg Ser Ser 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Asp Ser Ala Val Phe 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  70
<211>  452
<212>  PRT
<213>  Homo sapiens

<400>  70

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Phe Thr Phe Asn Ser Phe 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Gly Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Lys Asp Lys Ile Leu Trp Phe Gly Glu Pro Val Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 
        115                 120                 125             


Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr 
    130                 135                 140                 


Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
145                 150                 155                 160 


Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
                165                 170                 175     


Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
            180                 185                 190         


Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn 
        195                 200                 205             


His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser 
    210                 215                 220                 


Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
225                 230                 235                 240 


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
                245                 250                 255     


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
            260                 265                 270         


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
        275                 280                 285             


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
    290                 295                 300                 


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
305                 310                 315                 320 


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
                325                 330                 335     


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
            340                 345                 350         


Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val 
        355                 360                 365             


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
    370                 375                 380                 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
385                 390                 395                 400 


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
                405                 410                 415     


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
            420                 425                 430         


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
        435                 440                 445             


Ser Pro Gly Lys 
    450         


<210>  71
<211>  214
<212>  PRT
<213>  Homo sapiens

<400>  71

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Ser Asn Trp Pro Pro 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  72
<211>  87
<212>  PRT
<213>  Homo sapiens


<220>
<221>  HCDR1
<222>  (1)..(11)

<220>
<221>  HCDR2
<222>  (26)..(41)

<220>
<221>  HCDR3
<222>  (72)..(87)

<400>  72

Gly Ser Ile Ser Ser Gly Ser Tyr Tyr Trp Ser Trp Ile Arg Gln His 
1               5                   10                  15      


Pro Gly Lys Gly Leu Glu Trp Ile Gly Tyr Ile Tyr Tyr Ser Gly Ser 
            20                  25                  30          


Thr Tyr Tyr Asn Pro Ser Leu Lys Ser Arg Val Thr Ile Ser Val Asp 
        35                  40                  45              


Thr Ser Lys Asn Gln Phe Ser Leu Lys Leu Ser Ser Val Thr Ala Ala 
    50                  55                  60                  


Asp Thr Ala Val Tyr Tyr Cys Ala Arg Gly Ser Pro Tyr Arg Trp Tyr 
65                  70                  75                  80  


Asn Tyr Tyr Tyr Met Asp Val 
                85          


<210>  73
<211>  74
<212>  PRT
<213>  Homo sapiens


<220>
<221>  LCDR1
<222>  (1)..(11)

<220>
<221>  LCDR2
<222>  (27)..(33)

<220>
<221>  LCDR3
<222>  (66)..(74)

<400>  73

Arg Ala Ser Gln Ser Ile Ser Ser Trp Leu Ala Trp Tyr Gln Gln Lys 
1               5                   10                  15      


Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Asp Ala Ser Ser Leu Glu 
            20                  25                  30          


Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe 
        35                  40                  45              


Thr Leu Thr Ile Ser Ser Leu Gln Pro Asp Asp Phe Ala Thr Tyr Tyr 
    50                  55                  60                  


Cys Gln Gln His Arg Ser Tyr Pro Pro Thr 
65                  70                  


<210>  74
<211>  82
<212>  PRT
<213>  Homo sapiens


<220>
<221>  HCDR1
<222>  (1)..(9)

<220>
<221>  HCDR2
<222>  (24)..(40)

<220>
<221>  HCDR3
<222>  (71)..(82)

<400>  74

Tyr Thr Phe Thr Gly Tyr Tyr Met His Trp Val Arg Gln Ala Pro Gly 
1               5                   10                  15      


Gln Gly Leu Glu Trp Met Gly Trp Ile Asn Pro Asn Ser Gly Gly Thr 
            20                  25                  30          


Asn Tyr Ala Gln Lys Phe Gln Gly Arg Val Thr Met Thr Arg Asp Thr 
        35                  40                  45              


Ser Ile Ser Thr Ala Tyr Met Glu Leu Ser Arg Leu Arg Ser Asp Asp 
    50                  55                  60                  


Thr Ala Val Tyr Tyr Cys Ala Arg Asp Gln Ala His Gln Arg Ser Ser 
65                  70                  75                  80  


Tyr Asp 
        


<210>  75
<211>  74
<212>  PRT
<213>  Homo sapiens


<220>
<221>  LCDR1
<222>  (1)..(11)

<220>
<221>  LCDR2
<222>  (27)..(33)

<220>
<221>  LCDR3
<222>  (66)..(74)

<400>  75

Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn Trp Tyr Gln Gln Lys 
1               5                   10                  15      


Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Gly Ala Ser Ser Leu Gln 
            20                  25                  30          


Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 
        35                  40                  45              


Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr 
    50                  55                  60                  


Cys Gln Gln Arg Ser Ser Thr Pro Ile Thr 
65                  70                  


<210>  76
<211>  88
<212>  PRT
<213>  Homo sapiens


<220>
<221>  LCDR1
<222>  (1)..(11)

<220>
<221>  LCDR2
<222>  (26)..(41)

<220>
<221>  LCDR3
<222>  (72)..(88)

<400>  76

Gly Ser Ile Ser Ser Gly Gly Tyr Tyr Trp Ser Trp Ile Arg Gln His 
1               5                   10                  15      


Pro Gly Lys Gly Leu Glu Trp Ile Gly Tyr Ile Tyr Tyr Ser Gly Ser 
            20                  25                  30          


Thr Tyr Tyr Asn Pro Ser Leu Lys Ser Arg Val Thr Ile Ser Val Asp 
        35                  40                  45              


Thr Ser Lys Asn Gln Phe Ser Leu Lys Leu Ser Ser Val Thr Ala Ala 
    50                  55                  60                  


Asp Thr Ala Val Tyr Tyr Cys Ala Arg Ala Lys Ser Glu Leu Val Leu 
65                  70                  75                  80  


Pro Tyr Tyr Tyr Tyr Met Asp Val 
                85              


<210>  77
<211>  80
<212>  PRT
<213>  Homo sapiens


<220>
<221>  LCDR1
<222>  (1)..(17)

<220>
<221>  LCDR2
<222>  (33)..(39)

<220>
<221>  LCDR3
<222>  (72)..(80)

<400>  77

Lys Ser Ser Gln Ser Val Leu Phe Ser Ser Asn Asn Lys Asn Tyr Leu 
1               5                   10                  15      


Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile Tyr 
            20                  25                  30          


Trp Ala Ser Thr Arg Glu Ser Gly Val Pro Asp Arg Phe Ser Gly Ser 
        35                  40                  45              


Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Ala Glu 
    50                  55                  60                  


Asp Val Ala Val Tyr Tyr Cys Gln Gln Tyr Tyr Ser Leu Pro Pro Thr 
65                  70                  75                  80  


