                         SEQUENCE LISTING

<110>  The University of Manchester
 
<120>  C3b Inactivating Polypeptide

<130>  RIC/MP7371487

<150>  GB 1709222.2
<151>  2017-06-09

<160>  73    

<170>  PatentIn version 3.5

<210>  1
<211>  1663
<212>  PRT
<213>  Homo sapiens C3 (UniProt: P01024) including signal peptide

<400>  1

Met Gly Pro Thr Ser Gly Pro Ser Leu Leu Leu Leu Leu Leu Thr His 
1               5                   10                  15      


Leu Pro Leu Ala Leu Gly Ser Pro Met Tyr Ser Ile Ile Thr Pro Asn 
            20                  25                  30          


Ile Leu Arg Leu Glu Ser Glu Glu Thr Met Val Leu Glu Ala His Asp 
        35                  40                  45              


Ala Gln Gly Asp Val Pro Val Thr Val Thr Val His Asp Phe Pro Gly 
    50                  55                  60                  


Lys Lys Leu Val Leu Ser Ser Glu Lys Thr Val Leu Thr Pro Ala Thr 
65                  70                  75                  80  


Asn His Met Gly Asn Val Thr Phe Thr Ile Pro Ala Asn Arg Glu Phe 
                85                  90                  95      


Lys Ser Glu Lys Gly Arg Asn Lys Phe Val Thr Val Gln Ala Thr Phe 
            100                 105                 110         


Gly Thr Gln Val Val Glu Lys Val Val Leu Val Ser Leu Gln Ser Gly 
        115                 120                 125             


Tyr Leu Phe Ile Gln Thr Asp Lys Thr Ile Tyr Thr Pro Gly Ser Thr 
    130                 135                 140                 


Val Leu Tyr Arg Ile Phe Thr Val Asn His Lys Leu Leu Pro Val Gly 
145                 150                 155                 160 


Arg Thr Val Met Val Asn Ile Glu Asn Pro Glu Gly Ile Pro Val Lys 
                165                 170                 175     


Gln Asp Ser Leu Ser Ser Gln Asn Gln Leu Gly Val Leu Pro Leu Ser 
            180                 185                 190         


Trp Asp Ile Pro Glu Leu Val Asn Met Gly Gln Trp Lys Ile Arg Ala 
        195                 200                 205             


Tyr Tyr Glu Asn Ser Pro Gln Gln Val Phe Ser Thr Glu Phe Glu Val 
    210                 215                 220                 


Lys Glu Tyr Val Leu Pro Ser Phe Glu Val Ile Val Glu Pro Thr Glu 
225                 230                 235                 240 


Lys Phe Tyr Tyr Ile Tyr Asn Glu Lys Gly Leu Glu Val Thr Ile Thr 
                245                 250                 255     


Ala Arg Phe Leu Tyr Gly Lys Lys Val Glu Gly Thr Ala Phe Val Ile 
            260                 265                 270         


Phe Gly Ile Gln Asp Gly Glu Gln Arg Ile Ser Leu Pro Glu Ser Leu 
        275                 280                 285             


Lys Arg Ile Pro Ile Glu Asp Gly Ser Gly Glu Val Val Leu Ser Arg 
    290                 295                 300                 


Lys Val Leu Leu Asp Gly Val Gln Asn Pro Arg Ala Glu Asp Leu Val 
305                 310                 315                 320 


Gly Lys Ser Leu Tyr Val Ser Ala Thr Val Ile Leu His Ser Gly Ser 
                325                 330                 335     


Asp Met Val Gln Ala Glu Arg Ser Gly Ile Pro Ile Val Thr Ser Pro 
            340                 345                 350         


Tyr Gln Ile His Phe Thr Lys Thr Pro Lys Tyr Phe Lys Pro Gly Met 
        355                 360                 365             


Pro Phe Asp Leu Met Val Phe Val Thr Asn Pro Asp Gly Ser Pro Ala 
    370                 375                 380                 


Tyr Arg Val Pro Val Ala Val Gln Gly Glu Asp Thr Val Gln Ser Leu 
385                 390                 395                 400 


Thr Gln Gly Asp Gly Val Ala Lys Leu Ser Ile Asn Thr His Pro Ser 
                405                 410                 415     


Gln Lys Pro Leu Ser Ile Thr Val Arg Thr Lys Lys Gln Glu Leu Ser 
            420                 425                 430         


Glu Ala Glu Gln Ala Thr Arg Thr Met Gln Ala Leu Pro Tyr Ser Thr 
        435                 440                 445             


Val Gly Asn Ser Asn Asn Tyr Leu His Leu Ser Val Leu Arg Thr Glu 
    450                 455                 460                 


Leu Arg Pro Gly Glu Thr Leu Asn Val Asn Phe Leu Leu Arg Met Asp 
465                 470                 475                 480 


Arg Ala His Glu Ala Lys Ile Arg Tyr Tyr Thr Tyr Leu Ile Met Asn 
                485                 490                 495     


Lys Gly Arg Leu Leu Lys Ala Gly Arg Gln Val Arg Glu Pro Gly Gln 
            500                 505                 510         


Asp Leu Val Val Leu Pro Leu Ser Ile Thr Thr Asp Phe Ile Pro Ser 
        515                 520                 525             


Phe Arg Leu Val Ala Tyr Tyr Thr Leu Ile Gly Ala Ser Gly Gln Arg 
    530                 535                 540                 


Glu Val Val Ala Asp Ser Val Trp Val Asp Val Lys Asp Ser Cys Val 
545                 550                 555                 560 


Gly Ser Leu Val Val Lys Ser Gly Gln Ser Glu Asp Arg Gln Pro Val 
                565                 570                 575     


Pro Gly Gln Gln Met Thr Leu Lys Ile Glu Gly Asp His Gly Ala Arg 
            580                 585                 590         


Val Val Leu Val Ala Val Asp Lys Gly Val Phe Val Leu Asn Lys Lys 
        595                 600                 605             


Asn Lys Leu Thr Gln Ser Lys Ile Trp Asp Val Val Glu Lys Ala Asp 
    610                 615                 620                 


Ile Gly Cys Thr Pro Gly Ser Gly Lys Asp Tyr Ala Gly Val Phe Ser 
625                 630                 635                 640 


Asp Ala Gly Leu Thr Phe Thr Ser Ser Ser Gly Gln Gln Thr Ala Gln 
                645                 650                 655     


Arg Ala Glu Leu Gln Cys Pro Gln Pro Ala Ala Arg Arg Arg Arg Ser 
            660                 665                 670         


Val Gln Leu Thr Glu Lys Arg Met Asp Lys Val Gly Lys Tyr Pro Lys 
        675                 680                 685             


Glu Leu Arg Lys Cys Cys Glu Asp Gly Met Arg Glu Asn Pro Met Arg 
    690                 695                 700                 


Phe Ser Cys Gln Arg Arg Thr Arg Phe Ile Ser Leu Gly Glu Ala Cys 
705                 710                 715                 720 


Lys Lys Val Phe Leu Asp Cys Cys Asn Tyr Ile Thr Glu Leu Arg Arg 
                725                 730                 735     


Gln His Ala Arg Ala Ser His Leu Gly Leu Ala Arg Ser Asn Leu Asp 
            740                 745                 750         


Glu Asp Ile Ile Ala Glu Glu Asn Ile Val Ser Arg Ser Glu Phe Pro 
        755                 760                 765             


Glu Ser Trp Leu Trp Asn Val Glu Asp Leu Lys Glu Pro Pro Lys Asn 
    770                 775                 780                 


Gly Ile Ser Thr Lys Leu Met Asn Ile Phe Leu Lys Asp Ser Ile Thr 
785                 790                 795                 800 


Thr Trp Glu Ile Leu Ala Val Ser Met Ser Asp Lys Lys Gly Ile Cys 
                805                 810                 815     


Val Ala Asp Pro Phe Glu Val Thr Val Met Gln Asp Phe Phe Ile Asp 
            820                 825                 830         


Leu Arg Leu Pro Tyr Ser Val Val Arg Asn Glu Gln Val Glu Ile Arg 
        835                 840                 845             


Ala Val Leu Tyr Asn Tyr Arg Gln Asn Gln Glu Leu Lys Val Arg Val 
    850                 855                 860                 


Glu Leu Leu His Asn Pro Ala Phe Cys Ser Leu Ala Thr Thr Lys Arg 
865                 870                 875                 880 


Arg His Gln Gln Thr Val Thr Ile Pro Pro Lys Ser Ser Leu Ser Val 
                885                 890                 895     


Pro Tyr Val Ile Val Pro Leu Lys Thr Gly Leu Gln Glu Val Glu Val 
            900                 905                 910         


Lys Ala Ala Val Tyr His His Phe Ile Ser Asp Gly Val Arg Lys Ser 
        915                 920                 925             


Leu Lys Val Val Pro Glu Gly Ile Arg Met Asn Lys Thr Val Ala Val 
    930                 935                 940                 


Arg Thr Leu Asp Pro Glu Arg Leu Gly Arg Glu Gly Val Gln Lys Glu 
945                 950                 955                 960 


Asp Ile Pro Pro Ala Asp Leu Ser Asp Gln Val Pro Asp Thr Glu Ser 
                965                 970                 975     


Glu Thr Arg Ile Leu Leu Gln Gly Thr Pro Val Ala Gln Met Thr Glu 
            980                 985                 990         


Asp Ala Val Asp Ala Glu Arg Leu  Lys His Leu Ile Val  Thr Pro Ser 
        995                 1000                 1005             


Gly Cys  Gly Glu Gln Asn Met  Ile Gly Met Thr Pro  Thr Val Ile 
    1010                 1015                 1020             


Ala Val  His Tyr Leu Asp Glu  Thr Glu Gln Trp Glu  Lys Phe Gly 
    1025                 1030                 1035             


Leu Glu  Lys Arg Gln Gly Ala  Leu Glu Leu Ile Lys  Lys Gly Tyr 
    1040                 1045                 1050             


Thr Gln  Gln Leu Ala Phe Arg  Gln Pro Ser Ser Ala  Phe Ala Ala 
    1055                 1060                 1065             


Phe Val  Lys Arg Ala Pro Ser  Thr Trp Leu Thr Ala  Tyr Val Val 
    1070                 1075                 1080             


Lys Val  Phe Ser Leu Ala Val  Asn Leu Ile Ala Ile  Asp Ser Gln 
    1085                 1090                 1095             


Val Leu  Cys Gly Ala Val Lys  Trp Leu Ile Leu Glu  Lys Gln Lys 
    1100                 1105                 1110             


Pro Asp  Gly Val Phe Gln Glu  Asp Ala Pro Val Ile  His Gln Glu 
    1115                 1120                 1125             


Met Ile  Gly Gly Leu Arg Asn  Asn Asn Glu Lys Asp  Met Ala Leu 
    1130                 1135                 1140             


Thr Ala  Phe Val Leu Ile Ser  Leu Gln Glu Ala Lys  Asp Ile Cys 
    1145                 1150                 1155             


Glu Glu  Gln Val Asn Ser Leu  Pro Gly Ser Ile Thr  Lys Ala Gly 
    1160                 1165                 1170             


Asp Phe  Leu Glu Ala Asn Tyr  Met Asn Leu Gln Arg  Ser Tyr Thr 
    1175                 1180                 1185             


Val Ala  Ile Ala Gly Tyr Ala  Leu Ala Gln Met Gly  Arg Leu Lys 
    1190                 1195                 1200             


Gly Pro  Leu Leu Asn Lys Phe  Leu Thr Thr Ala Lys  Asp Lys Asn 
    1205                 1210                 1215             


Arg Trp  Glu Asp Pro Gly Lys  Gln Leu Tyr Asn Val  Glu Ala Thr 
    1220                 1225                 1230             


Ser Tyr  Ala Leu Leu Ala Leu  Leu Gln Leu Lys Asp  Phe Asp Phe 
    1235                 1240                 1245             


Val Pro  Pro Val Val Arg Trp  Leu Asn Glu Gln Arg  Tyr Tyr Gly 
    1250                 1255                 1260             


Gly Gly  Tyr Gly Ser Thr Gln  Ala Thr Phe Met Val  Phe Gln Ala 
    1265                 1270                 1275             


Leu Ala  Gln Tyr Gln Lys Asp  Ala Pro Asp His Gln  Glu Leu Asn 
    1280                 1285                 1290             


Leu Asp  Val Ser Leu Gln Leu  Pro Ser Arg Ser Ser  Lys Ile Thr 
    1295                 1300                 1305             


His Arg  Ile His Trp Glu Ser  Ala Ser Leu Leu Arg  Ser Glu Glu 
    1310                 1315                 1320             


Thr Lys  Glu Asn Glu Gly Phe  Thr Val Thr Ala Glu  Gly Lys Gly 
    1325                 1330                 1335             


Gln Gly  Thr Leu Ser Val Val  Thr Met Tyr His Ala  Lys Ala Lys 
    1340                 1345                 1350             


Asp Gln  Leu Thr Cys Asn Lys  Phe Asp Leu Lys Val  Thr Ile Lys 
    1355                 1360                 1365             


Pro Ala  Pro Glu Thr Glu Lys  Arg Pro Gln Asp Ala  Lys Asn Thr 
    1370                 1375                 1380             


Met Ile  Leu Glu Ile Cys Thr  Arg Tyr Arg Gly Asp  Gln Asp Ala 
    1385                 1390                 1395             


Thr Met  Ser Ile Leu Asp Ile  Ser Met Met Thr Gly  Phe Ala Pro 
    1400                 1405                 1410             


Asp Thr  Asp Asp Leu Lys Gln  Leu Ala Asn Gly Val  Asp Arg Tyr 
    1415                 1420                 1425             


Ile Ser  Lys Tyr Glu Leu Asp  Lys Ala Phe Ser Asp  Arg Asn Thr 
    1430                 1435                 1440             


Leu Ile  Ile Tyr Leu Asp Lys  Val Ser His Ser Glu  Asp Asp Cys 
    1445                 1450                 1455             


Leu Ala  Phe Lys Val His Gln  Tyr Phe Asn Val Glu  Leu Ile Gln 
    1460                 1465                 1470             


Pro Gly  Ala Val Lys Val Tyr  Ala Tyr Tyr Asn Leu  Glu Glu Ser 
    1475                 1480                 1485             


Cys Thr  Arg Phe Tyr His Pro  Glu Lys Glu Asp Gly  Lys Leu Asn 
    1490                 1495                 1500             


Lys Leu  Cys Arg Asp Glu Leu  Cys Arg Cys Ala Glu  Glu Asn Cys 
    1505                 1510                 1515             


Phe Ile  Gln Lys Ser Asp Asp  Lys Val Thr Leu Glu  Glu Arg Leu 
    1520                 1525                 1530             


Asp Lys  Ala Cys Glu Pro Gly  Val Asp Tyr Val Tyr  Lys Thr Arg 
    1535                 1540                 1545             


Leu Val  Lys Val Gln Leu Ser  Asn Asp Phe Asp Glu  Tyr Ile Met 
    1550                 1555                 1560             


Ala Ile  Glu Gln Thr Ile Lys  Ser Gly Ser Asp Glu  Val Gln Val 
    1565                 1570                 1575             


Gly Gln  Gln Arg Thr Phe Ile  Ser Pro Ile Lys Cys  Arg Glu Ala 
    1580                 1585                 1590             


Leu Lys  Leu Glu Glu Lys Lys  His Tyr Leu Met Trp  Gly Leu Ser 
    1595                 1600                 1605             


Ser Asp  Phe Trp Gly Glu Lys  Pro Asn Leu Ser Tyr  Ile Ile Gly 
    1610                 1615                 1620             


Lys Asp  Thr Trp Val Glu His  Trp Pro Glu Glu Asp  Glu Cys Gln 
    1625                 1630                 1635             


Asp Glu  Glu Asn Gln Lys Gln  Cys Gln Asp Leu Gly  Ala Phe Thr 
    1640                 1645                 1650             


Glu Ser  Met Val Val Phe Gly  Cys Pro Asn 
    1655                 1660             


<210>  2
<211>  645
<212>  PRT
<213>  Homo sapiens C3 beta chain (UniProt: P01024 residues 23-667)

<400>  2

Ser Pro Met Tyr Ser Ile Ile Thr Pro Asn Ile Leu Arg Leu Glu Ser 
1               5                   10                  15      


Glu Glu Thr Met Val Leu Glu Ala His Asp Ala Gln Gly Asp Val Pro 
            20                  25                  30          


Val Thr Val Thr Val His Asp Phe Pro Gly Lys Lys Leu Val Leu Ser 
        35                  40                  45              


Ser Glu Lys Thr Val Leu Thr Pro Ala Thr Asn His Met Gly Asn Val 
    50                  55                  60                  


Thr Phe Thr Ile Pro Ala Asn Arg Glu Phe Lys Ser Glu Lys Gly Arg 
65                  70                  75                  80  


Asn Lys Phe Val Thr Val Gln Ala Thr Phe Gly Thr Gln Val Val Glu 
                85                  90                  95      


Lys Val Val Leu Val Ser Leu Gln Ser Gly Tyr Leu Phe Ile Gln Thr 
            100                 105                 110         


Asp Lys Thr Ile Tyr Thr Pro Gly Ser Thr Val Leu Tyr Arg Ile Phe 
        115                 120                 125             


Thr Val Asn His Lys Leu Leu Pro Val Gly Arg Thr Val Met Val Asn 
    130                 135                 140                 


Ile Glu Asn Pro Glu Gly Ile Pro Val Lys Gln Asp Ser Leu Ser Ser 
145                 150                 155                 160 


Gln Asn Gln Leu Gly Val Leu Pro Leu Ser Trp Asp Ile Pro Glu Leu 
                165                 170                 175     


Val Asn Met Gly Gln Trp Lys Ile Arg Ala Tyr Tyr Glu Asn Ser Pro 
            180                 185                 190         


Gln Gln Val Phe Ser Thr Glu Phe Glu Val Lys Glu Tyr Val Leu Pro 
        195                 200                 205             


Ser Phe Glu Val Ile Val Glu Pro Thr Glu Lys Phe Tyr Tyr Ile Tyr 
    210                 215                 220                 


Asn Glu Lys Gly Leu Glu Val Thr Ile Thr Ala Arg Phe Leu Tyr Gly 
225                 230                 235                 240 


Lys Lys Val Glu Gly Thr Ala Phe Val Ile Phe Gly Ile Gln Asp Gly 
                245                 250                 255     


Glu Gln Arg Ile Ser Leu Pro Glu Ser Leu Lys Arg Ile Pro Ile Glu 
            260                 265                 270         


Asp Gly Ser Gly Glu Val Val Leu Ser Arg Lys Val Leu Leu Asp Gly 
        275                 280                 285             


Val Gln Asn Pro Arg Ala Glu Asp Leu Val Gly Lys Ser Leu Tyr Val 
    290                 295                 300                 


Ser Ala Thr Val Ile Leu His Ser Gly Ser Asp Met Val Gln Ala Glu 
305                 310                 315                 320 


Arg Ser Gly Ile Pro Ile Val Thr Ser Pro Tyr Gln Ile His Phe Thr 
                325                 330                 335     


Lys Thr Pro Lys Tyr Phe Lys Pro Gly Met Pro Phe Asp Leu Met Val 
            340                 345                 350         


Phe Val Thr Asn Pro Asp Gly Ser Pro Ala Tyr Arg Val Pro Val Ala 
        355                 360                 365             


Val Gln Gly Glu Asp Thr Val Gln Ser Leu Thr Gln Gly Asp Gly Val 
    370                 375                 380                 


Ala Lys Leu Ser Ile Asn Thr His Pro Ser Gln Lys Pro Leu Ser Ile 
385                 390                 395                 400 


Thr Val Arg Thr Lys Lys Gln Glu Leu Ser Glu Ala Glu Gln Ala Thr 
                405                 410                 415     


Arg Thr Met Gln Ala Leu Pro Tyr Ser Thr Val Gly Asn Ser Asn Asn 
            420                 425                 430         


Tyr Leu His Leu Ser Val Leu Arg Thr Glu Leu Arg Pro Gly Glu Thr 
        435                 440                 445             


Leu Asn Val Asn Phe Leu Leu Arg Met Asp Arg Ala His Glu Ala Lys 
    450                 455                 460                 


Ile Arg Tyr Tyr Thr Tyr Leu Ile Met Asn Lys Gly Arg Leu Leu Lys 
465                 470                 475                 480 


Ala Gly Arg Gln Val Arg Glu Pro Gly Gln Asp Leu Val Val Leu Pro 
                485                 490                 495     


Leu Ser Ile Thr Thr Asp Phe Ile Pro Ser Phe Arg Leu Val Ala Tyr 
            500                 505                 510         


Tyr Thr Leu Ile Gly Ala Ser Gly Gln Arg Glu Val Val Ala Asp Ser 
        515                 520                 525             


Val Trp Val Asp Val Lys Asp Ser Cys Val Gly Ser Leu Val Val Lys 
    530                 535                 540                 


Ser Gly Gln Ser Glu Asp Arg Gln Pro Val Pro Gly Gln Gln Met Thr 
545                 550                 555                 560 


Leu Lys Ile Glu Gly Asp His Gly Ala Arg Val Val Leu Val Ala Val 
                565                 570                 575     


Asp Lys Gly Val Phe Val Leu Asn Lys Lys Asn Lys Leu Thr Gln Ser 
            580                 585                 590         


Lys Ile Trp Asp Val Val Glu Lys Ala Asp Ile Gly Cys Thr Pro Gly 
        595                 600                 605             


Ser Gly Lys Asp Tyr Ala Gly Val Phe Ser Asp Ala Gly Leu Thr Phe 
    610                 615                 620                 


Thr Ser Ser Ser Gly Gln Gln Thr Ala Gln Arg Ala Glu Leu Gln Cys 
625                 630                 635                 640 


Pro Gln Pro Ala Ala 
                645 


<210>  3
<211>  915
<212>  PRT
<213>  Homo sapiens C3 alpha' chain (UniProt: P01024 residues 749-1663)

<400>  3

Ser Asn Leu Asp Glu Asp Ile Ile Ala Glu Glu Asn Ile Val Ser Arg 
1               5                   10                  15      


Ser Glu Phe Pro Glu Ser Trp Leu Trp Asn Val Glu Asp Leu Lys Glu 
            20                  25                  30          


Pro Pro Lys Asn Gly Ile Ser Thr Lys Leu Met Asn Ile Phe Leu Lys 
        35                  40                  45              


Asp Ser Ile Thr Thr Trp Glu Ile Leu Ala Val Ser Met Ser Asp Lys 
    50                  55                  60                  


Lys Gly Ile Cys Val Ala Asp Pro Phe Glu Val Thr Val Met Gln Asp 
65                  70                  75                  80  


Phe Phe Ile Asp Leu Arg Leu Pro Tyr Ser Val Val Arg Asn Glu Gln 
                85                  90                  95      


Val Glu Ile Arg Ala Val Leu Tyr Asn Tyr Arg Gln Asn Gln Glu Leu 
            100                 105                 110         


Lys Val Arg Val Glu Leu Leu His Asn Pro Ala Phe Cys Ser Leu Ala 
        115                 120                 125             


Thr Thr Lys Arg Arg His Gln Gln Thr Val Thr Ile Pro Pro Lys Ser 
    130                 135                 140                 


Ser Leu Ser Val Pro Tyr Val Ile Val Pro Leu Lys Thr Gly Leu Gln 
145                 150                 155                 160 


Glu Val Glu Val Lys Ala Ala Val Tyr His His Phe Ile Ser Asp Gly 
                165                 170                 175     


Val Arg Lys Ser Leu Lys Val Val Pro Glu Gly Ile Arg Met Asn Lys 
            180                 185                 190         


Thr Val Ala Val Arg Thr Leu Asp Pro Glu Arg Leu Gly Arg Glu Gly 
        195                 200                 205             


Val Gln Lys Glu Asp Ile Pro Pro Ala Asp Leu Ser Asp Gln Val Pro 
    210                 215                 220                 


Asp Thr Glu Ser Glu Thr Arg Ile Leu Leu Gln Gly Thr Pro Val Ala 
225                 230                 235                 240 


Gln Met Thr Glu Asp Ala Val Asp Ala Glu Arg Leu Lys His Leu Ile 
                245                 250                 255     


Val Thr Pro Ser Gly Cys Gly Glu Gln Asn Met Ile Gly Met Thr Pro 
            260                 265                 270         


Thr Val Ile Ala Val His Tyr Leu Asp Glu Thr Glu Gln Trp Glu Lys 
        275                 280                 285             


Phe Gly Leu Glu Lys Arg Gln Gly Ala Leu Glu Leu Ile Lys Lys Gly 
    290                 295                 300                 


Tyr Thr Gln Gln Leu Ala Phe Arg Gln Pro Ser Ser Ala Phe Ala Ala 
305                 310                 315                 320 


Phe Val Lys Arg Ala Pro Ser Thr Trp Leu Thr Ala Tyr Val Val Lys 
                325                 330                 335     


Val Phe Ser Leu Ala Val Asn Leu Ile Ala Ile Asp Ser Gln Val Leu 
            340                 345                 350         


Cys Gly Ala Val Lys Trp Leu Ile Leu Glu Lys Gln Lys Pro Asp Gly 
        355                 360                 365             


Val Phe Gln Glu Asp Ala Pro Val Ile His Gln Glu Met Ile Gly Gly 
    370                 375                 380                 


Leu Arg Asn Asn Asn Glu Lys Asp Met Ala Leu Thr Ala Phe Val Leu 
385                 390                 395                 400 


Ile Ser Leu Gln Glu Ala Lys Asp Ile Cys Glu Glu Gln Val Asn Ser 
                405                 410                 415     


Leu Pro Gly Ser Ile Thr Lys Ala Gly Asp Phe Leu Glu Ala Asn Tyr 
            420                 425                 430         


Met Asn Leu Gln Arg Ser Tyr Thr Val Ala Ile Ala Gly Tyr Ala Leu 
        435                 440                 445             


Ala Gln Met Gly Arg Leu Lys Gly Pro Leu Leu Asn Lys Phe Leu Thr 
    450                 455                 460                 


Thr Ala Lys Asp Lys Asn Arg Trp Glu Asp Pro Gly Lys Gln Leu Tyr 
465                 470                 475                 480 


Asn Val Glu Ala Thr Ser Tyr Ala Leu Leu Ala Leu Leu Gln Leu Lys 
                485                 490                 495     


Asp Phe Asp Phe Val Pro Pro Val Val Arg Trp Leu Asn Glu Gln Arg 
            500                 505                 510         


Tyr Tyr Gly Gly Gly Tyr Gly Ser Thr Gln Ala Thr Phe Met Val Phe 
        515                 520                 525             


Gln Ala Leu Ala Gln Tyr Gln Lys Asp Ala Pro Asp His Gln Glu Leu 
    530                 535                 540                 


Asn Leu Asp Val Ser Leu Gln Leu Pro Ser Arg Ser Ser Lys Ile Thr 
545                 550                 555                 560 


His Arg Ile His Trp Glu Ser Ala Ser Leu Leu Arg Ser Glu Glu Thr 
                565                 570                 575     


Lys Glu Asn Glu Gly Phe Thr Val Thr Ala Glu Gly Lys Gly Gln Gly 
            580                 585                 590         


Thr Leu Ser Val Val Thr Met Tyr His Ala Lys Ala Lys Asp Gln Leu 
        595                 600                 605             


Thr Cys Asn Lys Phe Asp Leu Lys Val Thr Ile Lys Pro Ala Pro Glu 
    610                 615                 620                 


Thr Glu Lys Arg Pro Gln Asp Ala Lys Asn Thr Met Ile Leu Glu Ile 
625                 630                 635                 640 


Cys Thr Arg Tyr Arg Gly Asp Gln Asp Ala Thr Met Ser Ile Leu Asp 
                645                 650                 655     


Ile Ser Met Met Thr Gly Phe Ala Pro Asp Thr Asp Asp Leu Lys Gln 
            660                 665                 670         


Leu Ala Asn Gly Val Asp Arg Tyr Ile Ser Lys Tyr Glu Leu Asp Lys 
        675                 680                 685             


Ala Phe Ser Asp Arg Asn Thr Leu Ile Ile Tyr Leu Asp Lys Val Ser 
    690                 695                 700                 


His Ser Glu Asp Asp Cys Leu Ala Phe Lys Val His Gln Tyr Phe Asn 
705                 710                 715                 720 


Val Glu Leu Ile Gln Pro Gly Ala Val Lys Val Tyr Ala Tyr Tyr Asn 
                725                 730                 735     


Leu Glu Glu Ser Cys Thr Arg Phe Tyr His Pro Glu Lys Glu Asp Gly 
            740                 745                 750         


Lys Leu Asn Lys Leu Cys Arg Asp Glu Leu Cys Arg Cys Ala Glu Glu 
        755                 760                 765             


Asn Cys Phe Ile Gln Lys Ser Asp Asp Lys Val Thr Leu Glu Glu Arg 
    770                 775                 780                 


Leu Asp Lys Ala Cys Glu Pro Gly Val Asp Tyr Val Tyr Lys Thr Arg 
785                 790                 795                 800 


Leu Val Lys Val Gln Leu Ser Asn Asp Phe Asp Glu Tyr Ile Met Ala 
                805                 810                 815     


Ile Glu Gln Thr Ile Lys Ser Gly Ser Asp Glu Val Gln Val Gly Gln 
            820                 825                 830         


Gln Arg Thr Phe Ile Ser Pro Ile Lys Cys Arg Glu Ala Leu Lys Leu 
        835                 840                 845             


Glu Glu Lys Lys His Tyr Leu Met Trp Gly Leu Ser Ser Asp Phe Trp 
    850                 855                 860                 


Gly Glu Lys Pro Asn Leu Ser Tyr Ile Ile Gly Lys Asp Thr Trp Val 
865                 870                 875                 880 


Glu His Trp Pro Glu Glu Asp Glu Cys Gln Asp Glu Glu Asn Gln Lys 
                885                 890                 895     


Gln Cys Gln Asp Leu Gly Ala Phe Thr Glu Ser Met Val Val Phe Gly 
            900                 905                 910         


Cys Pro Asn 
        915 


<210>  4
<211>  77
<212>  PRT
<213>  Homo sapiens C3a (UniProt: P01024 residues 672-748)

<400>  4

Ser Val Gln Leu Thr Glu Lys Arg Met Asp Lys Val Gly Lys Tyr Pro 
1               5                   10                  15      


Lys Glu Leu Arg Lys Cys Cys Glu Asp Gly Met Arg Glu Asn Pro Met 
            20                  25                  30          


Arg Phe Ser Cys Gln Arg Arg Thr Arg Phe Ile Ser Leu Gly Glu Ala 
        35                  40                  45              


Cys Lys Lys Val Phe Leu Asp Cys Cys Asn Tyr Ile Thr Glu Leu Arg 
    50                  55                  60                  


Arg Gln His Ala Arg Ala Ser His Leu Gly Leu Ala Arg 
65                  70                  75          


<210>  5
<211>  555
<212>  PRT
<213>  Homo sapiens C3 alpha' chain fragment 1 (UniProt: P01024 residues 749-1303)

<400>  5

Ser Asn Leu Asp Glu Asp Ile Ile Ala Glu Glu Asn Ile Val Ser Arg 
1               5                   10                  15      


Ser Glu Phe Pro Glu Ser Trp Leu Trp Asn Val Glu Asp Leu Lys Glu 
            20                  25                  30          


Pro Pro Lys Asn Gly Ile Ser Thr Lys Leu Met Asn Ile Phe Leu Lys 
        35                  40                  45              


Asp Ser Ile Thr Thr Trp Glu Ile Leu Ala Val Ser Met Ser Asp Lys 
    50                  55                  60                  


Lys Gly Ile Cys Val Ala Asp Pro Phe Glu Val Thr Val Met Gln Asp 
65                  70                  75                  80  


Phe Phe Ile Asp Leu Arg Leu Pro Tyr Ser Val Val Arg Asn Glu Gln 
                85                  90                  95      


Val Glu Ile Arg Ala Val Leu Tyr Asn Tyr Arg Gln Asn Gln Glu Leu 
            100                 105                 110         


Lys Val Arg Val Glu Leu Leu His Asn Pro Ala Phe Cys Ser Leu Ala 
        115                 120                 125             


Thr Thr Lys Arg Arg His Gln Gln Thr Val Thr Ile Pro Pro Lys Ser 
    130                 135                 140                 


Ser Leu Ser Val Pro Tyr Val Ile Val Pro Leu Lys Thr Gly Leu Gln 
145                 150                 155                 160 


Glu Val Glu Val Lys Ala Ala Val Tyr His His Phe Ile Ser Asp Gly 
                165                 170                 175     


Val Arg Lys Ser Leu Lys Val Val Pro Glu Gly Ile Arg Met Asn Lys 
            180                 185                 190         


Thr Val Ala Val Arg Thr Leu Asp Pro Glu Arg Leu Gly Arg Glu Gly 
        195                 200                 205             


Val Gln Lys Glu Asp Ile Pro Pro Ala Asp Leu Ser Asp Gln Val Pro 
    210                 215                 220                 


Asp Thr Glu Ser Glu Thr Arg Ile Leu Leu Gln Gly Thr Pro Val Ala 
225                 230                 235                 240 


Gln Met Thr Glu Asp Ala Val Asp Ala Glu Arg Leu Lys His Leu Ile 
                245                 250                 255     


Val Thr Pro Ser Gly Cys Gly Glu Gln Asn Met Ile Gly Met Thr Pro 
            260                 265                 270         


Thr Val Ile Ala Val His Tyr Leu Asp Glu Thr Glu Gln Trp Glu Lys 
        275                 280                 285             


Phe Gly Leu Glu Lys Arg Gln Gly Ala Leu Glu Leu Ile Lys Lys Gly 
    290                 295                 300                 


Tyr Thr Gln Gln Leu Ala Phe Arg Gln Pro Ser Ser Ala Phe Ala Ala 
305                 310                 315                 320 


Phe Val Lys Arg Ala Pro Ser Thr Trp Leu Thr Ala Tyr Val Val Lys 
                325                 330                 335     


Val Phe Ser Leu Ala Val Asn Leu Ile Ala Ile Asp Ser Gln Val Leu 
            340                 345                 350         


Cys Gly Ala Val Lys Trp Leu Ile Leu Glu Lys Gln Lys Pro Asp Gly 
        355                 360                 365             


Val Phe Gln Glu Asp Ala Pro Val Ile His Gln Glu Met Ile Gly Gly 
    370                 375                 380                 


Leu Arg Asn Asn Asn Glu Lys Asp Met Ala Leu Thr Ala Phe Val Leu 
385                 390                 395                 400 


Ile Ser Leu Gln Glu Ala Lys Asp Ile Cys Glu Glu Gln Val Asn Ser 
                405                 410                 415     


Leu Pro Gly Ser Ile Thr Lys Ala Gly Asp Phe Leu Glu Ala Asn Tyr 
            420                 425                 430         


Met Asn Leu Gln Arg Ser Tyr Thr Val Ala Ile Ala Gly Tyr Ala Leu 
        435                 440                 445             


Ala Gln Met Gly Arg Leu Lys Gly Pro Leu Leu Asn Lys Phe Leu Thr 
    450                 455                 460                 


Thr Ala Lys Asp Lys Asn Arg Trp Glu Asp Pro Gly Lys Gln Leu Tyr 
465                 470                 475                 480 


Asn Val Glu Ala Thr Ser Tyr Ala Leu Leu Ala Leu Leu Gln Leu Lys 
                485                 490                 495     


Asp Phe Asp Phe Val Pro Pro Val Val Arg Trp Leu Asn Glu Gln Arg 
            500                 505                 510         


Tyr Tyr Gly Gly Gly Tyr Gly Ser Thr Gln Ala Thr Phe Met Val Phe 
        515                 520                 525             


Gln Ala Leu Ala Gln Tyr Gln Lys Asp Ala Pro Asp His Gln Glu Leu 
    530                 535                 540                 


Asn Leu Asp Val Ser Leu Gln Leu Pro Ser Arg 
545                 550                 555 


<210>  6
<211>  343
<212>  PRT
<213>  Homo sapiens C3 alpha' chain fragment 2 (UniProt: P01024 residues 1321-1663)

<400>  6

Ser Glu Glu Thr Lys Glu Asn Glu Gly Phe Thr Val Thr Ala Glu Gly 
1               5                   10                  15      


Lys Gly Gln Gly Thr Leu Ser Val Val Thr Met Tyr His Ala Lys Ala 
            20                  25                  30          


Lys Asp Gln Leu Thr Cys Asn Lys Phe Asp Leu Lys Val Thr Ile Lys 
        35                  40                  45              


Pro Ala Pro Glu Thr Glu Lys Arg Pro Gln Asp Ala Lys Asn Thr Met 
    50                  55                  60                  


Ile Leu Glu Ile Cys Thr Arg Tyr Arg Gly Asp Gln Asp Ala Thr Met 
65                  70                  75                  80  


Ser Ile Leu Asp Ile Ser Met Met Thr Gly Phe Ala Pro Asp Thr Asp 
                85                  90                  95      


Asp Leu Lys Gln Leu Ala Asn Gly Val Asp Arg Tyr Ile Ser Lys Tyr 
            100                 105                 110         


Glu Leu Asp Lys Ala Phe Ser Asp Arg Asn Thr Leu Ile Ile Tyr Leu 
        115                 120                 125             


Asp Lys Val Ser His Ser Glu Asp Asp Cys Leu Ala Phe Lys Val His 
    130                 135                 140                 


Gln Tyr Phe Asn Val Glu Leu Ile Gln Pro Gly Ala Val Lys Val Tyr 
145                 150                 155                 160 


Ala Tyr Tyr Asn Leu Glu Glu Ser Cys Thr Arg Phe Tyr His Pro Glu 
                165                 170                 175     


Lys Glu Asp Gly Lys Leu Asn Lys Leu Cys Arg Asp Glu Leu Cys Arg 
            180                 185                 190         


Cys Ala Glu Glu Asn Cys Phe Ile Gln Lys Ser Asp Asp Lys Val Thr 
        195                 200                 205             


Leu Glu Glu Arg Leu Asp Lys Ala Cys Glu Pro Gly Val Asp Tyr Val 
    210                 215                 220                 


Tyr Lys Thr Arg Leu Val Lys Val Gln Leu Ser Asn Asp Phe Asp Glu 
225                 230                 235                 240 


Tyr Ile Met Ala Ile Glu Gln Thr Ile Lys Ser Gly Ser Asp Glu Val 
                245                 250                 255     


Gln Val Gly Gln Gln Arg Thr Phe Ile Ser Pro Ile Lys Cys Arg Glu 
            260                 265                 270         


Ala Leu Lys Leu Glu Glu Lys Lys His Tyr Leu Met Trp Gly Leu Ser 
        275                 280                 285             


Ser Asp Phe Trp Gly Glu Lys Pro Asn Leu Ser Tyr Ile Ile Gly Lys 
    290                 295                 300                 


Asp Thr Trp Val Glu His Trp Pro Glu Glu Asp Glu Cys Gln Asp Glu 
305                 310                 315                 320 


Glu Asn Gln Lys Gln Cys Gln Asp Leu Gly Ala Phe Thr Glu Ser Met 
                325                 330                 335     


Val Val Phe Gly Cys Pro Asn 
            340             


<210>  7
<211>  17
<212>  PRT
<213>  Homo sapiens C3f (UniProt: P01024 residues 1304-1320)

<400>  7

Ser Ser Lys Ile Thr His Arg Ile His Trp Glu Ser Ala Ser Leu Leu 
1               5                   10                  15      


Arg 
    


<210>  8
<211>  583
<212>  PRT
<213>  Homo sapiens Complement Factor I (UniProt: P05156)

<400>  8

Met Lys Leu Leu His Val Phe Leu Leu Phe Leu Cys Phe His Leu Arg 
1               5                   10                  15      


Phe Cys Lys Val Thr Tyr Thr Ser Gln Glu Asp Leu Val Glu Lys Lys 
            20                  25                  30          


Cys Leu Ala Lys Lys Tyr Thr His Leu Ser Cys Asp Lys Val Phe Cys 
        35                  40                  45              


Gln Pro Trp Gln Arg Cys Ile Glu Gly Thr Cys Val Cys Lys Leu Pro 
    50                  55                  60                  


Tyr Gln Cys Pro Lys Asn Gly Thr Ala Val Cys Ala Thr Asn Arg Arg 
65                  70                  75                  80  


Ser Phe Pro Thr Tyr Cys Gln Gln Lys Ser Leu Glu Cys Leu His Pro 
                85                  90                  95      


Gly Thr Lys Phe Leu Asn Asn Gly Thr Cys Thr Ala Glu Gly Lys Phe 
            100                 105                 110         


Ser Val Ser Leu Lys His Gly Asn Thr Asp Ser Glu Gly Ile Val Glu 
        115                 120                 125             


Val Lys Leu Val Asp Gln Asp Lys Thr Met Phe Ile Cys Lys Ser Ser 
    130                 135                 140                 


Trp Ser Met Arg Glu Ala Asn Val Ala Cys Leu Asp Leu Gly Phe Gln 
145                 150                 155                 160 


Gln Gly Ala Asp Thr Gln Arg Arg Phe Lys Leu Ser Asp Leu Ser Ile 
                165                 170                 175     


Asn Ser Thr Glu Cys Leu His Val His Cys Arg Gly Leu Glu Thr Ser 
            180                 185                 190         


Leu Ala Glu Cys Thr Phe Thr Lys Arg Arg Thr Met Gly Tyr Gln Asp 
        195                 200                 205             


Phe Ala Asp Val Val Cys Tyr Thr Gln Lys Ala Asp Ser Pro Met Asp 
    210                 215                 220                 


Asp Phe Phe Gln Cys Val Asn Gly Lys Tyr Ile Ser Gln Met Lys Ala 
225                 230                 235                 240 


Cys Asp Gly Ile Asn Asp Cys Gly Asp Gln Ser Asp Glu Leu Cys Cys 
                245                 250                 255     


Lys Ala Cys Gln Gly Lys Gly Phe His Cys Lys Ser Gly Val Cys Ile 
            260                 265                 270         


Pro Ser Gln Tyr Gln Cys Asn Gly Glu Val Asp Cys Ile Thr Gly Glu 
        275                 280                 285             


Asp Glu Val Gly Cys Ala Gly Phe Ala Ser Val Thr Gln Glu Glu Thr 
    290                 295                 300                 


Glu Ile Leu Thr Ala Asp Met Asp Ala Glu Arg Arg Arg Ile Lys Ser 
305                 310                 315                 320 


Leu Leu Pro Lys Leu Ser Cys Gly Val Lys Asn Arg Met His Ile Arg 
                325                 330                 335     


Arg Lys Arg Ile Val Gly Gly Lys Arg Ala Gln Leu Gly Asp Leu Pro 
            340                 345                 350         


Trp Gln Val Ala Ile Lys Asp Ala Ser Gly Ile Thr Cys Gly Gly Ile 
        355                 360                 365             


Tyr Ile Gly Gly Cys Trp Ile Leu Thr Ala Ala His Cys Leu Arg Ala 
    370                 375                 380                 


Ser Lys Thr His Arg Tyr Gln Ile Trp Thr Thr Val Val Asp Trp Ile 
385                 390                 395                 400 


His Pro Asp Leu Lys Arg Ile Val Ile Glu Tyr Val Asp Arg Ile Ile 
                405                 410                 415     


Phe His Glu Asn Tyr Asn Ala Gly Thr Tyr Gln Asn Asp Ile Ala Leu 
            420                 425                 430         


Ile Glu Met Lys Lys Asp Gly Asn Lys Lys Asp Cys Glu Leu Pro Arg 
        435                 440                 445             


Ser Ile Pro Ala Cys Val Pro Trp Ser Pro Tyr Leu Phe Gln Pro Asn 
    450                 455                 460                 


Asp Thr Cys Ile Val Ser Gly Trp Gly Arg Glu Lys Asp Asn Glu Arg 
465                 470                 475                 480 


Val Phe Ser Leu Gln Trp Gly Glu Val Lys Leu Ile Ser Asn Cys Ser 
                485                 490                 495     


Lys Phe Tyr Gly Asn Arg Phe Tyr Glu Lys Glu Met Glu Cys Ala Gly 
            500                 505                 510         


Thr Tyr Asp Gly Ser Ile Asp Ala Cys Lys Gly Asp Ser Gly Gly Pro 
        515                 520                 525             


Leu Val Cys Met Asp Ala Asn Asn Val Thr Tyr Val Trp Gly Val Val 
    530                 535                 540                 


Ser Trp Gly Glu Asn Cys Gly Lys Pro Glu Phe Pro Gly Val Tyr Thr 
545                 550                 555                 560 


Lys Val Ala Asn Tyr Phe Asp Trp Ile Ser Tyr His Val Gly Arg Pro 
                565                 570                 575     


Phe Ile Ser Gln Tyr Asn Val 
            580             


<210>  9
<211>  235
<212>  PRT
<213>  Homo sapiens Complement Factor I proteolytic domain (UniProt: P05156 residues 340-574)

<400>  9

Ile Val Gly Gly Lys Arg Ala Gln Leu Gly Asp Leu Pro Trp Gln Val 
1               5                   10                  15      


Ala Ile Lys Asp Ala Ser Gly Ile Thr Cys Gly Gly Ile Tyr Ile Gly 
            20                  25                  30          


Gly Cys Trp Ile Leu Thr Ala Ala His Cys Leu Arg Ala Ser Lys Thr 
        35                  40                  45              


His Arg Tyr Gln Ile Trp Thr Thr Val Val Asp Trp Ile His Pro Asp 
    50                  55                  60                  


Leu Lys Arg Ile Val Ile Glu Tyr Val Asp Arg Ile Ile Phe His Glu 
65                  70                  75                  80  


Asn Tyr Asn Ala Gly Thr Tyr Gln Asn Asp Ile Ala Leu Ile Glu Met 
                85                  90                  95      


Lys Lys Asp Gly Asn Lys Lys Asp Cys Glu Leu Pro Arg Ser Ile Pro 
            100                 105                 110         


Ala Cys Val Pro Trp Ser Pro Tyr Leu Phe Gln Pro Asn Asp Thr Cys 
        115                 120                 125             


Ile Val Ser Gly Trp Gly Arg Glu Lys Asp Asn Glu Arg Val Phe Ser 
    130                 135                 140                 


Leu Gln Trp Gly Glu Val Lys Leu Ile Ser Asn Cys Ser Lys Phe Tyr 
145                 150                 155                 160 


Gly Asn Arg Phe Tyr Glu Lys Glu Met Glu Cys Ala Gly Thr Tyr Asp 
                165                 170                 175     


Gly Ser Ile Asp Ala Cys Lys Gly Asp Ser Gly Gly Pro Leu Val Cys 
            180                 185                 190         


Met Asp Ala Asn Asn Val Thr Tyr Val Trp Gly Val Val Ser Trp Gly 
        195                 200                 205             


Glu Asn Cys Gly Lys Pro Glu Phe Pro Gly Val Tyr Thr Lys Val Ala 
    210                 215                 220                 


Asn Tyr Phe Asp Trp Ile Ser Tyr His Val Gly 
225                 230                 235 


<210>  10
<211>  1231
<212>  PRT
<213>  Homo sapiens Complement Factor H (UniProt: P08603)

<400>  10

Met Arg Leu Leu Ala Lys Ile Ile Cys Leu Met Leu Trp Ala Ile Cys 
1               5                   10                  15      


Val Ala Glu Asp Cys Asn Glu Leu Pro Pro Arg Arg Asn Thr Glu Ile 
            20                  25                  30          


Leu Thr Gly Ser Trp Ser Asp Gln Thr Tyr Pro Glu Gly Thr Gln Ala 
        35                  40                  45              


Ile Tyr Lys Cys Arg Pro Gly Tyr Arg Ser Leu Gly Asn Val Ile Met 
    50                  55                  60                  


Val Cys Arg Lys Gly Glu Trp Val Ala Leu Asn Pro Leu Arg Lys Cys 
65                  70                  75                  80  


Gln Lys Arg Pro Cys Gly His Pro Gly Asp Thr Pro Phe Gly Thr Phe 
                85                  90                  95      


Thr Leu Thr Gly Gly Asn Val Phe Glu Tyr Gly Val Lys Ala Val Tyr 
            100                 105                 110         


Thr Cys Asn Glu Gly Tyr Gln Leu Leu Gly Glu Ile Asn Tyr Arg Glu 
        115                 120                 125             


Cys Asp Thr Asp Gly Trp Thr Asn Asp Ile Pro Ile Cys Glu Val Val 
    130                 135                 140                 


Lys Cys Leu Pro Val Thr Ala Pro Glu Asn Gly Lys Ile Val Ser Ser 
145                 150                 155                 160 


Ala Met Glu Pro Asp Arg Glu Tyr His Phe Gly Gln Ala Val Arg Phe 
                165                 170                 175     


Val Cys Asn Ser Gly Tyr Lys Ile Glu Gly Asp Glu Glu Met His Cys 
            180                 185                 190         


Ser Asp Asp Gly Phe Trp Ser Lys Glu Lys Pro Lys Cys Val Glu Ile 
        195                 200                 205             


Ser Cys Lys Ser Pro Asp Val Ile Asn Gly Ser Pro Ile Ser Gln Lys 
    210                 215                 220                 


Ile Ile Tyr Lys Glu Asn Glu Arg Phe Gln Tyr Lys Cys Asn Met Gly 
225                 230                 235                 240 


Tyr Glu Tyr Ser Glu Arg Gly Asp Ala Val Cys Thr Glu Ser Gly Trp 
                245                 250                 255     


Arg Pro Leu Pro Ser Cys Glu Glu Lys Ser Cys Asp Asn Pro Tyr Ile 
            260                 265                 270         


Pro Asn Gly Asp Tyr Ser Pro Leu Arg Ile Lys His Arg Thr Gly Asp 
        275                 280                 285             


Glu Ile Thr Tyr Gln Cys Arg Asn Gly Phe Tyr Pro Ala Thr Arg Gly 
    290                 295                 300                 


Asn Thr Ala Lys Cys Thr Ser Thr Gly Trp Ile Pro Ala Pro Arg Cys 
305                 310                 315                 320 


Thr Leu Lys Pro Cys Asp Tyr Pro Asp Ile Lys His Gly Gly Leu Tyr 
                325                 330                 335     


His Glu Asn Met Arg Arg Pro Tyr Phe Pro Val Ala Val Gly Lys Tyr 
            340                 345                 350         


Tyr Ser Tyr Tyr Cys Asp Glu His Phe Glu Thr Pro Ser Gly Ser Tyr 
        355                 360                 365             


Trp Asp His Ile His Cys Thr Gln Asp Gly Trp Ser Pro Ala Val Pro 
    370                 375                 380                 


Cys Leu Arg Lys Cys Tyr Phe Pro Tyr Leu Glu Asn Gly Tyr Asn Gln 
385                 390                 395                 400 


Asn Tyr Gly Arg Lys Phe Val Gln Gly Lys Ser Ile Asp Val Ala Cys 
                405                 410                 415     


His Pro Gly Tyr Ala Leu Pro Lys Ala Gln Thr Thr Val Thr Cys Met 
            420                 425                 430         


Glu Asn Gly Trp Ser Pro Thr Pro Arg Cys Ile Arg Val Lys Thr Cys 
        435                 440                 445             


Ser Lys Ser Ser Ile Asp Ile Glu Asn Gly Phe Ile Ser Glu Ser Gln 
    450                 455                 460                 


Tyr Thr Tyr Ala Leu Lys Glu Lys Ala Lys Tyr Gln Cys Lys Leu Gly 
465                 470                 475                 480 


Tyr Val Thr Ala Asp Gly Glu Thr Ser Gly Ser Ile Thr Cys Gly Lys 
                485                 490                 495     


Asp Gly Trp Ser Ala Gln Pro Thr Cys Ile Lys Ser Cys Asp Ile Pro 
            500                 505                 510         


Val Phe Met Asn Ala Arg Thr Lys Asn Asp Phe Thr Trp Phe Lys Leu 
        515                 520                 525             


Asn Asp Thr Leu Asp Tyr Glu Cys His Asp Gly Tyr Glu Ser Asn Thr 
    530                 535                 540                 


Gly Ser Thr Thr Gly Ser Ile Val Cys Gly Tyr Asn Gly Trp Ser Asp 
545                 550                 555                 560 


Leu Pro Ile Cys Tyr Glu Arg Glu Cys Glu Leu Pro Lys Ile Asp Val 
                565                 570                 575     


His Leu Val Pro Asp Arg Lys Lys Asp Gln Tyr Lys Val Gly Glu Val 
            580                 585                 590         


Leu Lys Phe Ser Cys Lys Pro Gly Phe Thr Ile Val Gly Pro Asn Ser 
        595                 600                 605             


Val Gln Cys Tyr His Phe Gly Leu Ser Pro Asp Leu Pro Ile Cys Lys 
    610                 615                 620                 


Glu Gln Val Gln Ser Cys Gly Pro Pro Pro Glu Leu Leu Asn Gly Asn 
625                 630                 635                 640 


Val Lys Glu Lys Thr Lys Glu Glu Tyr Gly His Ser Glu Val Val Glu 
                645                 650                 655     


Tyr Tyr Cys Asn Pro Arg Phe Leu Met Lys Gly Pro Asn Lys Ile Gln 
            660                 665                 670         


Cys Val Asp Gly Glu Trp Thr Thr Leu Pro Val Cys Ile Val Glu Glu 
        675                 680                 685             


Ser Thr Cys Gly Asp Ile Pro Glu Leu Glu His Gly Trp Ala Gln Leu 
    690                 695                 700                 


Ser Ser Pro Pro Tyr Tyr Tyr Gly Asp Ser Val Glu Phe Asn Cys Ser 
705                 710                 715                 720 


Glu Ser Phe Thr Met Ile Gly His Arg Ser Ile Thr Cys Ile His Gly 
                725                 730                 735     


Val Trp Thr Gln Leu Pro Gln Cys Val Ala Ile Asp Lys Leu Lys Lys 
            740                 745                 750         


Cys Lys Ser Ser Asn Leu Ile Ile Leu Glu Glu His Leu Lys Asn Lys 
        755                 760                 765             


Lys Glu Phe Asp His Asn Ser Asn Ile Arg Tyr Arg Cys Arg Gly Lys 
    770                 775                 780                 


Glu Gly Trp Ile His Thr Val Cys Ile Asn Gly Arg Trp Asp Pro Glu 
785                 790                 795                 800 


Val Asn Cys Ser Met Ala Gln Ile Gln Leu Cys Pro Pro Pro Pro Gln 
                805                 810                 815     


Ile Pro Asn Ser His Asn Met Thr Thr Thr Leu Asn Tyr Arg Asp Gly 
            820                 825                 830         


Glu Lys Val Ser Val Leu Cys Gln Glu Asn Tyr Leu Ile Gln Glu Gly 
        835                 840                 845             


Glu Glu Ile Thr Cys Lys Asp Gly Arg Trp Gln Ser Ile Pro Leu Cys 
    850                 855                 860                 


Val Glu Lys Ile Pro Cys Ser Gln Pro Pro Gln Ile Glu His Gly Thr 
865                 870                 875                 880 


Ile Asn Ser Ser Arg Ser Ser Gln Glu Ser Tyr Ala His Gly Thr Lys 
                885                 890                 895     


Leu Ser Tyr Thr Cys Glu Gly Gly Phe Arg Ile Ser Glu Glu Asn Glu 
            900                 905                 910         


Thr Thr Cys Tyr Met Gly Lys Trp Ser Ser Pro Pro Gln Cys Glu Gly 
        915                 920                 925             


Leu Pro Cys Lys Ser Pro Pro Glu Ile Ser His Gly Val Val Ala His 
    930                 935                 940                 


Met Ser Asp Ser Tyr Gln Tyr Gly Glu Glu Val Thr Tyr Lys Cys Phe 
945                 950                 955                 960 


Glu Gly Phe Gly Ile Asp Gly Pro Ala Ile Ala Lys Cys Leu Gly Glu 
                965                 970                 975     


Lys Trp Ser His Pro Pro Ser Cys Ile Lys Thr Asp Cys Leu Ser Leu 
            980                 985                 990         


Pro Ser Phe Glu Asn Ala Ile Pro  Met Gly Glu Lys Lys  Asp Val Tyr 
        995                 1000                 1005             


Lys Ala  Gly Glu Gln Val Thr  Tyr Thr Cys Ala Thr  Tyr Tyr Lys 
    1010                 1015                 1020             


Met Asp  Gly Ala Ser Asn Val  Thr Cys Ile Asn Ser  Arg Trp Thr 
    1025                 1030                 1035             


Gly Arg  Pro Thr Cys Arg Asp  Thr Ser Cys Val Asn  Pro Pro Thr 
    1040                 1045                 1050             


Val Gln  Asn Ala Tyr Ile Val  Ser Arg Gln Met Ser  Lys Tyr Pro 
    1055                 1060                 1065             


Ser Gly  Glu Arg Val Arg Tyr  Gln Cys Arg Ser Pro  Tyr Glu Met 
    1070                 1075                 1080             


Phe Gly  Asp Glu Glu Val Met  Cys Leu Asn Gly Asn  Trp Thr Glu 
    1085                 1090                 1095             


Pro Pro  Gln Cys Lys Asp Ser  Thr Gly Lys Cys Gly  Pro Pro Pro 
    1100                 1105                 1110             


Pro Ile  Asp Asn Gly Asp Ile  Thr Ser Phe Pro Leu  Ser Val Tyr 
    1115                 1120                 1125             


Ala Pro  Ala Ser Ser Val Glu  Tyr Gln Cys Gln Asn  Leu Tyr Gln 
    1130                 1135                 1140             


Leu Glu  Gly Asn Lys Arg Ile  Thr Cys Arg Asn Gly  Gln Trp Ser 
    1145                 1150                 1155             


Glu Pro  Pro Lys Cys Leu His  Pro Cys Val Ile Ser  Arg Glu Ile 
    1160                 1165                 1170             


Met Glu  Asn Tyr Asn Ile Ala  Leu Arg Trp Thr Ala  Lys Gln Lys 
    1175                 1180                 1185             


Leu Tyr  Ser Arg Thr Gly Glu  Ser Val Glu Phe Val  Cys Lys Arg 
    1190                 1195                 1200             


Gly Tyr  Arg Leu Ser Ser Arg  Ser His Thr Leu Arg  Thr Thr Cys 
    1205                 1210                 1215             


Trp Asp  Gly Lys Leu Glu Tyr  Pro Thr Cys Ala Lys  Arg 
    1220                 1225                 1230     


<210>  11
<211>  246
<212>  PRT
<213>  Homo sapiens Complement Factor H co-factor region (UniProt: P08603 residues 19-264)

<400>  11

Glu Asp Cys Asn Glu Leu Pro Pro Arg Arg Asn Thr Glu Ile Leu Thr 
1               5                   10                  15      


Gly Ser Trp Ser Asp Gln Thr Tyr Pro Glu Gly Thr Gln Ala Ile Tyr 
            20                  25                  30          


Lys Cys Arg Pro Gly Tyr Arg Ser Leu Gly Asn Val Ile Met Val Cys 
        35                  40                  45              


Arg Lys Gly Glu Trp Val Ala Leu Asn Pro Leu Arg Lys Cys Gln Lys 
    50                  55                  60                  


Arg Pro Cys Gly His Pro Gly Asp Thr Pro Phe Gly Thr Phe Thr Leu 
65                  70                  75                  80  


Thr Gly Gly Asn Val Phe Glu Tyr Gly Val Lys Ala Val Tyr Thr Cys 
                85                  90                  95      


Asn Glu Gly Tyr Gln Leu Leu Gly Glu Ile Asn Tyr Arg Glu Cys Asp 
            100                 105                 110         


Thr Asp Gly Trp Thr Asn Asp Ile Pro Ile Cys Glu Val Val Lys Cys 
        115                 120                 125             


Leu Pro Val Thr Ala Pro Glu Asn Gly Lys Ile Val Ser Ser Ala Met 
    130                 135                 140                 


Glu Pro Asp Arg Glu Tyr His Phe Gly Gln Ala Val Arg Phe Val Cys 
145                 150                 155                 160 


Asn Ser Gly Tyr Lys Ile Glu Gly Asp Glu Glu Met His Cys Ser Asp 
                165                 170                 175     


Asp Gly Phe Trp Ser Lys Glu Lys Pro Lys Cys Val Glu Ile Ser Cys 
            180                 185                 190         


Lys Ser Pro Asp Val Ile Asn Gly Ser Pro Ile Ser Gln Lys Ile Ile 
        195                 200                 205             


Tyr Lys Glu Asn Glu Arg Phe Gln Tyr Lys Cys Asn Met Gly Tyr Glu 
    210                 215                 220                 


Tyr Ser Glu Arg Gly Asp Ala Val Cys Thr Glu Ser Gly Trp Arg Pro 
225                 230                 235                 240 


Leu Pro Ser Cys Glu Glu 
                245     


<210>  12
<211>  2039
<212>  PRT
<213>  Homo sapiens Complement Receptor 1 (UniProt: P17927)

<400>  12

Met Gly Ala Ser Ser Pro Arg Ser Pro Glu Pro Val Gly Pro Pro Ala 
1               5                   10                  15      


Pro Gly Leu Pro Phe Cys Cys Gly Gly Ser Leu Leu Ala Val Val Val 
            20                  25                  30          


Leu Leu Ala Leu Pro Val Ala Trp Gly Gln Cys Asn Ala Pro Glu Trp 
        35                  40                  45              


Leu Pro Phe Ala Arg Pro Thr Asn Leu Thr Asp Glu Phe Glu Phe Pro 
    50                  55                  60                  


Ile Gly Thr Tyr Leu Asn Tyr Glu Cys Arg Pro Gly Tyr Ser Gly Arg 
65                  70                  75                  80  


Pro Phe Ser Ile Ile Cys Leu Lys Asn Ser Val Trp Thr Gly Ala Lys 
                85                  90                  95      


Asp Arg Cys Arg Arg Lys Ser Cys Arg Asn Pro Pro Asp Pro Val Asn 
            100                 105                 110         


Gly Met Val His Val Ile Lys Gly Ile Gln Phe Gly Ser Gln Ile Lys 
        115                 120                 125             


Tyr Ser Cys Thr Lys Gly Tyr Arg Leu Ile Gly Ser Ser Ser Ala Thr 
    130                 135                 140                 


Cys Ile Ile Ser Gly Asp Thr Val Ile Trp Asp Asn Glu Thr Pro Ile 
145                 150                 155                 160 


Cys Asp Arg Ile Pro Cys Gly Leu Pro Pro Thr Ile Thr Asn Gly Asp 
                165                 170                 175     


Phe Ile Ser Thr Asn Arg Glu Asn Phe His Tyr Gly Ser Val Val Thr 
            180                 185                 190         


Tyr Arg Cys Asn Pro Gly Ser Gly Gly Arg Lys Val Phe Glu Leu Val 
        195                 200                 205             


Gly Glu Pro Ser Ile Tyr Cys Thr Ser Asn Asp Asp Gln Val Gly Ile 
    210                 215                 220                 


Trp Ser Gly Pro Ala Pro Gln Cys Ile Ile Pro Asn Lys Cys Thr Pro 
225                 230                 235                 240 


Pro Asn Val Glu Asn Gly Ile Leu Val Ser Asp Asn Arg Ser Leu Phe 
                245                 250                 255     


Ser Leu Asn Glu Val Val Glu Phe Arg Cys Gln Pro Gly Phe Val Met 
            260                 265                 270         


Lys Gly Pro Arg Arg Val Lys Cys Gln Ala Leu Asn Lys Trp Glu Pro 
        275                 280                 285             


Glu Leu Pro Ser Cys Ser Arg Val Cys Gln Pro Pro Pro Asp Val Leu 
    290                 295                 300                 


His Ala Glu Arg Thr Gln Arg Asp Lys Asp Asn Phe Ser Pro Gly Gln 
305                 310                 315                 320 


Glu Val Phe Tyr Ser Cys Glu Pro Gly Tyr Asp Leu Arg Gly Ala Ala 
                325                 330                 335     


Ser Met Arg Cys Thr Pro Gln Gly Asp Trp Ser Pro Ala Ala Pro Thr 
            340                 345                 350         


Cys Glu Val Lys Ser Cys Asp Asp Phe Met Gly Gln Leu Leu Asn Gly 
        355                 360                 365             


Arg Val Leu Phe Pro Val Asn Leu Gln Leu Gly Ala Lys Val Asp Phe 
    370                 375                 380                 


Val Cys Asp Glu Gly Phe Gln Leu Lys Gly Ser Ser Ala Ser Tyr Cys 
385                 390                 395                 400 


Val Leu Ala Gly Met Glu Ser Leu Trp Asn Ser Ser Val Pro Val Cys 
                405                 410                 415     


Glu Gln Ile Phe Cys Pro Ser Pro Pro Val Ile Pro Asn Gly Arg His 
            420                 425                 430         


Thr Gly Lys Pro Leu Glu Val Phe Pro Phe Gly Lys Thr Val Asn Tyr 
        435                 440                 445             


Thr Cys Asp Pro His Pro Asp Arg Gly Thr Ser Phe Asp Leu Ile Gly 
    450                 455                 460                 


Glu Ser Thr Ile Arg Cys Thr Ser Asp Pro Gln Gly Asn Gly Val Trp 
465                 470                 475                 480 


Ser Ser Pro Ala Pro Arg Cys Gly Ile Leu Gly His Cys Gln Ala Pro 
                485                 490                 495     


Asp His Phe Leu Phe Ala Lys Leu Lys Thr Gln Thr Asn Ala Ser Asp 
            500                 505                 510         


Phe Pro Ile Gly Thr Ser Leu Lys Tyr Glu Cys Arg Pro Glu Tyr Tyr 
        515                 520                 525             


Gly Arg Pro Phe Ser Ile Thr Cys Leu Asp Asn Leu Val Trp Ser Ser 
    530                 535                 540                 


Pro Lys Asp Val Cys Lys Arg Lys Ser Cys Lys Thr Pro Pro Asp Pro 
545                 550                 555                 560 


Val Asn Gly Met Val His Val Ile Thr Asp Ile Gln Val Gly Ser Arg 
                565                 570                 575     


Ile Asn Tyr Ser Cys Thr Thr Gly His Arg Leu Ile Gly His Ser Ser 
            580                 585                 590         


Ala Glu Cys Ile Leu Ser Gly Asn Ala Ala His Trp Ser Thr Lys Pro 
        595                 600                 605             


Pro Ile Cys Gln Arg Ile Pro Cys Gly Leu Pro Pro Thr Ile Ala Asn 
    610                 615                 620                 


Gly Asp Phe Ile Ser Thr Asn Arg Glu Asn Phe His Tyr Gly Ser Val 
625                 630                 635                 640 


Val Thr Tyr Arg Cys Asn Pro Gly Ser Gly Gly Arg Lys Val Phe Glu 
                645                 650                 655     


Leu Val Gly Glu Pro Ser Ile Tyr Cys Thr Ser Asn Asp Asp Gln Val 
            660                 665                 670         


Gly Ile Trp Ser Gly Pro Ala Pro Gln Cys Ile Ile Pro Asn Lys Cys 
        675                 680                 685             


Thr Pro Pro Asn Val Glu Asn Gly Ile Leu Val Ser Asp Asn Arg Ser 
    690                 695                 700                 


Leu Phe Ser Leu Asn Glu Val Val Glu Phe Arg Cys Gln Pro Gly Phe 
705                 710                 715                 720 


Val Met Lys Gly Pro Arg Arg Val Lys Cys Gln Ala Leu Asn Lys Trp 
                725                 730                 735     


Glu Pro Glu Leu Pro Ser Cys Ser Arg Val Cys Gln Pro Pro Pro Asp 
            740                 745                 750         


Val Leu His Ala Glu Arg Thr Gln Arg Asp Lys Asp Asn Phe Ser Pro 
        755                 760                 765             


Gly Gln Glu Val Phe Tyr Ser Cys Glu Pro Gly Tyr Asp Leu Arg Gly 
    770                 775                 780                 


Ala Ala Ser Met Arg Cys Thr Pro Gln Gly Asp Trp Ser Pro Ala Ala 
785                 790                 795                 800 


Pro Thr Cys Glu Val Lys Ser Cys Asp Asp Phe Met Gly Gln Leu Leu 
                805                 810                 815     


Asn Gly Arg Val Leu Phe Pro Val Asn Leu Gln Leu Gly Ala Lys Val 
            820                 825                 830         


Asp Phe Val Cys Asp Glu Gly Phe Gln Leu Lys Gly Ser Ser Ala Ser 
        835                 840                 845             


Tyr Cys Val Leu Ala Gly Met Glu Ser Leu Trp Asn Ser Ser Val Pro 
    850                 855                 860                 


Val Cys Glu Gln Ile Phe Cys Pro Ser Pro Pro Val Ile Pro Asn Gly 
865                 870                 875                 880 


Arg His Thr Gly Lys Pro Leu Glu Val Phe Pro Phe Gly Lys Ala Val 
                885                 890                 895     


Asn Tyr Thr Cys Asp Pro His Pro Asp Arg Gly Thr Ser Phe Asp Leu 
            900                 905                 910         


Ile Gly Glu Ser Thr Ile Arg Cys Thr Ser Asp Pro Gln Gly Asn Gly 
        915                 920                 925             


Val Trp Ser Ser Pro Ala Pro Arg Cys Gly Ile Leu Gly His Cys Gln 
    930                 935                 940                 


Ala Pro Asp His Phe Leu Phe Ala Lys Leu Lys Thr Gln Thr Asn Ala 
945                 950                 955                 960 


Ser Asp Phe Pro Ile Gly Thr Ser Leu Lys Tyr Glu Cys Arg Pro Glu 
                965                 970                 975     


Tyr Tyr Gly Arg Pro Phe Ser Ile Thr Cys Leu Asp Asn Leu Val Trp 
            980                 985                 990         


Ser Ser Pro Lys Asp Val Cys Lys  Arg Lys Ser Cys Lys  Thr Pro Pro 
        995                 1000                 1005             


Asp Pro  Val Asn Gly Met Val  His Val Ile Thr Asp  Ile Gln Val 
    1010                 1015                 1020             


Gly Ser  Arg Ile Asn Tyr Ser  Cys Thr Thr Gly His  Arg Leu Ile 
    1025                 1030                 1035             


Gly His  Ser Ser Ala Glu Cys  Ile Leu Ser Gly Asn  Thr Ala His 
    1040                 1045                 1050             


Trp Ser  Thr Lys Pro Pro Ile  Cys Gln Arg Ile Pro  Cys Gly Leu 
    1055                 1060                 1065             


Pro Pro  Thr Ile Ala Asn Gly  Asp Phe Ile Ser Thr  Asn Arg Glu 
    1070                 1075                 1080             


Asn Phe  His Tyr Gly Ser Val  Val Thr Tyr Arg Cys  Asn Leu Gly 
    1085                 1090                 1095             


Ser Arg  Gly Arg Lys Val Phe  Glu Leu Val Gly Glu  Pro Ser Ile 
    1100                 1105                 1110             


Tyr Cys  Thr Ser Asn Asp Asp  Gln Val Gly Ile Trp  Ser Gly Pro 
    1115                 1120                 1125             


Ala Pro  Gln Cys Ile Ile Pro  Asn Lys Cys Thr Pro  Pro Asn Val 
    1130                 1135                 1140             


Glu Asn  Gly Ile Leu Val Ser  Asp Asn Arg Ser Leu  Phe Ser Leu 
    1145                 1150                 1155             


Asn Glu  Val Val Glu Phe Arg  Cys Gln Pro Gly Phe  Val Met Lys 
    1160                 1165                 1170             


Gly Pro  Arg Arg Val Lys Cys  Gln Ala Leu Asn Lys  Trp Glu Pro 
    1175                 1180                 1185             


Glu Leu  Pro Ser Cys Ser Arg  Val Cys Gln Pro Pro  Pro Glu Ile 
    1190                 1195                 1200             


Leu His  Gly Glu His Thr Pro  Ser His Gln Asp Asn  Phe Ser Pro 
    1205                 1210                 1215             


Gly Gln  Glu Val Phe Tyr Ser  Cys Glu Pro Gly Tyr  Asp Leu Arg 
    1220                 1225                 1230             


Gly Ala  Ala Ser Leu His Cys  Thr Pro Gln Gly Asp  Trp Ser Pro 
    1235                 1240                 1245             


Glu Ala  Pro Arg Cys Ala Val  Lys Ser Cys Asp Asp  Phe Leu Gly 
    1250                 1255                 1260             


Gln Leu  Pro His Gly Arg Val  Leu Phe Pro Leu Asn  Leu Gln Leu 
    1265                 1270                 1275             


Gly Ala  Lys Val Ser Phe Val  Cys Asp Glu Gly Phe  Arg Leu Lys 
    1280                 1285                 1290             


Gly Ser  Ser Val Ser His Cys  Val Leu Val Gly Met  Arg Ser Leu 
    1295                 1300                 1305             


Trp Asn  Asn Ser Val Pro Val  Cys Glu His Ile Phe  Cys Pro Asn 
    1310                 1315                 1320             


Pro Pro  Ala Ile Leu Asn Gly  Arg His Thr Gly Thr  Pro Ser Gly 
    1325                 1330                 1335             


Asp Ile  Pro Tyr Gly Lys Glu  Ile Ser Tyr Thr Cys  Asp Pro His 
    1340                 1345                 1350             


Pro Asp  Arg Gly Met Thr Phe  Asn Leu Ile Gly Glu  Ser Thr Ile 
    1355                 1360                 1365             


Arg Cys  Thr Ser Asp Pro His  Gly Asn Gly Val Trp  Ser Ser Pro 
    1370                 1375                 1380             


Ala Pro  Arg Cys Glu Leu Ser  Val Arg Ala Gly His  Cys Lys Thr 
    1385                 1390                 1395             


Pro Glu  Gln Phe Pro Phe Ala  Ser Pro Thr Ile Pro  Ile Asn Asp 
    1400                 1405                 1410             


Phe Glu  Phe Pro Val Gly Thr  Ser Leu Asn Tyr Glu  Cys Arg Pro 
    1415                 1420                 1425             


Gly Tyr  Phe Gly Lys Met Phe  Ser Ile Ser Cys Leu  Glu Asn Leu 
    1430                 1435                 1440             


Val Trp  Ser Ser Val Glu Asp  Asn Cys Arg Arg Lys  Ser Cys Gly 
    1445                 1450                 1455             


Pro Pro  Pro Glu Pro Phe Asn  Gly Met Val His Ile  Asn Thr Asp 
    1460                 1465                 1470             


Thr Gln  Phe Gly Ser Thr Val  Asn Tyr Ser Cys Asn  Glu Gly Phe 
    1475                 1480                 1485             


Arg Leu  Ile Gly Ser Pro Ser  Thr Thr Cys Leu Val  Ser Gly Asn 
    1490                 1495                 1500             


Asn Val  Thr Trp Asp Lys Lys  Ala Pro Ile Cys Glu  Ile Ile Ser 
    1505                 1510                 1515             


Cys Glu  Pro Pro Pro Thr Ile  Ser Asn Gly Asp Phe  Tyr Ser Asn 
    1520                 1525                 1530             


Asn Arg  Thr Ser Phe His Asn  Gly Thr Val Val Thr  Tyr Gln Cys 
    1535                 1540                 1545             


His Thr  Gly Pro Asp Gly Glu  Gln Leu Phe Glu Leu  Val Gly Glu 
    1550                 1555                 1560             


Arg Ser  Ile Tyr Cys Thr Ser  Lys Asp Asp Gln Val  Gly Val Trp 
    1565                 1570                 1575             


Ser Ser  Pro Pro Pro Arg Cys  Ile Ser Thr Asn Lys  Cys Thr Ala 
    1580                 1585                 1590             


Pro Glu  Val Glu Asn Ala Ile  Arg Val Pro Gly Asn  Arg Ser Phe 
    1595                 1600                 1605             


Phe Ser  Leu Thr Glu Ile Ile  Arg Phe Arg Cys Gln  Pro Gly Phe 
    1610                 1615                 1620             


Val Met  Val Gly Ser His Thr  Val Gln Cys Gln Thr  Asn Gly Arg 
    1625                 1630                 1635             


Trp Gly  Pro Lys Leu Pro His  Cys Ser Arg Val Cys  Gln Pro Pro 
    1640                 1645                 1650             


Pro Glu  Ile Leu His Gly Glu  His Thr Leu Ser His  Gln Asp Asn 
    1655                 1660                 1665             


Phe Ser  Pro Gly Gln Glu Val  Phe Tyr Ser Cys Glu  Pro Ser Tyr 
    1670                 1675                 1680             


Asp Leu  Arg Gly Ala Ala Ser  Leu His Cys Thr Pro  Gln Gly Asp 
    1685                 1690                 1695             


Trp Ser  Pro Glu Ala Pro Arg  Cys Thr Val Lys Ser  Cys Asp Asp 
    1700                 1705                 1710             


Phe Leu  Gly Gln Leu Pro His  Gly Arg Val Leu Leu  Pro Leu Asn 
    1715                 1720                 1725             


Leu Gln  Leu Gly Ala Lys Val  Ser Phe Val Cys Asp  Glu Gly Phe 
    1730                 1735                 1740             


Arg Leu  Lys Gly Arg Ser Ala  Ser His Cys Val Leu  Ala Gly Met 
    1745                 1750                 1755             


Lys Ala  Leu Trp Asn Ser Ser  Val Pro Val Cys Glu  Gln Ile Phe 
    1760                 1765                 1770             


Cys Pro  Asn Pro Pro Ala Ile  Leu Asn Gly Arg His  Thr Gly Thr 
    1775                 1780                 1785             


Pro Phe  Gly Asp Ile Pro Tyr  Gly Lys Glu Ile Ser  Tyr Ala Cys 
    1790                 1795                 1800             


Asp Thr  His Pro Asp Arg Gly  Met Thr Phe Asn Leu  Ile Gly Glu 
    1805                 1810                 1815             


Ser Ser  Ile Arg Cys Thr Ser  Asp Pro Gln Gly Asn  Gly Val Trp 
    1820                 1825                 1830             


Ser Ser  Pro Ala Pro Arg Cys  Glu Leu Ser Val Pro  Ala Ala Cys 
    1835                 1840                 1845             


Pro His  Pro Pro Lys Ile Gln  Asn Gly His Tyr Ile  Gly Gly His 
    1850                 1855                 1860             


Val Ser  Leu Tyr Leu Pro Gly  Met Thr Ile Ser Tyr  Ile Cys Asp 
    1865                 1870                 1875             


Pro Gly  Tyr Leu Leu Val Gly  Lys Gly Phe Ile Phe  Cys Thr Asp 
    1880                 1885                 1890             


Gln Gly  Ile Trp Ser Gln Leu  Asp His Tyr Cys Lys  Glu Val Asn 
    1895                 1900                 1905             


Cys Ser  Phe Pro Leu Phe Met  Asn Gly Ile Ser Lys  Glu Leu Glu 
    1910                 1915                 1920             


Met Lys  Lys Val Tyr His Tyr  Gly Asp Tyr Val Thr  Leu Lys Cys 
    1925                 1930                 1935             


Glu Asp  Gly Tyr Thr Leu Glu  Gly Ser Pro Trp Ser  Gln Cys Gln 
    1940                 1945                 1950             


Ala Asp  Asp Arg Trp Asp Pro  Pro Leu Ala Lys Cys  Thr Ser Arg 
    1955                 1960                 1965             


Thr His  Asp Ala Leu Ile Val  Gly Thr Leu Ser Gly  Thr Ile Phe 
    1970                 1975                 1980             


Phe Ile  Leu Leu Ile Ile Phe  Leu Ser Trp Ile Ile  Leu Lys His 
    1985                 1990                 1995             


Arg Lys  Gly Asn Asn Ala His  Glu Asn Pro Lys Glu  Val Ala Ile 
    2000                 2005                 2010             


His Leu  His Ser Gln Gly Gly  Ser Ser Val His Pro  Arg Thr Leu 
    2015                 2020                 2025             


Gln Thr  Asn Glu Glu Asn Ser  Arg Val Leu Pro 
    2030                 2035                 


<210>  13
<211>  194
<212>  PRT
<213>  Homo sapiens Complement Receptor 1 CCPs 8-10 (UniProt: P17927 residues 491 to 684)

<400>  13

Gly His Cys Gln Ala Pro Asp His Phe Leu Phe Ala Lys Leu Lys Thr 
1               5                   10                  15      


Gln Thr Asn Ala Ser Asp Phe Pro Ile Gly Thr Ser Leu Lys Tyr Glu 
            20                  25                  30          


Cys Arg Pro Glu Tyr Tyr Gly Arg Pro Phe Ser Ile Thr Cys Leu Asp 
        35                  40                  45              


Asn Leu Val Trp Ser Ser Pro Lys Asp Val Cys Lys Arg Lys Ser Cys 
    50                  55                  60                  


Lys Thr Pro Pro Asp Pro Val Asn Gly Met Val His Val Ile Thr Asp 
65                  70                  75                  80  


Ile Gln Val Gly Ser Arg Ile Asn Tyr Ser Cys Thr Thr Gly His Arg 
                85                  90                  95      


Leu Ile Gly His Ser Ser Ala Glu Cys Ile Leu Ser Gly Asn Ala Ala 
            100                 105                 110         


His Trp Ser Thr Lys Pro Pro Ile Cys Gln Arg Ile Pro Cys Gly Leu 
        115                 120                 125             


Pro Pro Thr Ile Ala Asn Gly Asp Phe Ile Ser Thr Asn Arg Glu Asn 
    130                 135                 140                 


Phe His Tyr Gly Ser Val Val Thr Tyr Arg Cys Asn Pro Gly Ser Gly 
145                 150                 155                 160 


Gly Arg Lys Val Phe Glu Leu Val Gly Glu Pro Ser Ile Tyr Cys Thr 
                165                 170                 175     


Ser Asn Asp Asp Gln Val Gly Ile Trp Ser Gly Pro Ala Pro Gln Cys 
            180                 185                 190         


Ile Ile 
        


<210>  14
<211>  194
<212>  PRT
<213>  Homo sapiens Complement Receptor 1 CCPs 15-17 (UniProt: P17927 residues 941 to 1134)

<400>  14

Gly His Cys Gln Ala Pro Asp His Phe Leu Phe Ala Lys Leu Lys Thr 
1               5                   10                  15      


Gln Thr Asn Ala Ser Asp Phe Pro Ile Gly Thr Ser Leu Lys Tyr Glu 
            20                  25                  30          


Cys Arg Pro Glu Tyr Tyr Gly Arg Pro Phe Ser Ile Thr Cys Leu Asp 
        35                  40                  45              


Asn Leu Val Trp Ser Ser Pro Lys Asp Val Cys Lys Arg Lys Ser Cys 
    50                  55                  60                  


Lys Thr Pro Pro Asp Pro Val Asn Gly Met Val His Val Ile Thr Asp 
65                  70                  75                  80  


Ile Gln Val Gly Ser Arg Ile Asn Tyr Ser Cys Thr Thr Gly His Arg 
                85                  90                  95      


Leu Ile Gly His Ser Ser Ala Glu Cys Ile Leu Ser Gly Asn Thr Ala 
            100                 105                 110         


His Trp Ser Thr Lys Pro Pro Ile Cys Gln Arg Ile Pro Cys Gly Leu 
        115                 120                 125             


Pro Pro Thr Ile Ala Asn Gly Asp Phe Ile Ser Thr Asn Arg Glu Asn 
    130                 135                 140                 


Phe His Tyr Gly Ser Val Val Thr Tyr Arg Cys Asn Leu Gly Ser Arg 
145                 150                 155                 160 


Gly Arg Lys Val Phe Glu Leu Val Gly Glu Pro Ser Ile Tyr Cys Thr 
                165                 170                 175     


Ser Asn Asp Asp Gln Val Gly Ile Trp Ser Gly Pro Ala Pro Gln Cys 
            180                 185                 190         


Ile Ile 
        


<210>  15
<211>  392
<212>  PRT
<213>  Homo sapiens CD46 (UniProt: P15529)

<400>  15

Met Glu Pro Pro Gly Arg Arg Glu Cys Pro Phe Pro Ser Trp Arg Phe 
1               5                   10                  15      


Pro Gly Leu Leu Leu Ala Ala Met Val Leu Leu Leu Tyr Ser Phe Ser 
            20                  25                  30          


Asp Ala Cys Glu Glu Pro Pro Thr Phe Glu Ala Met Glu Leu Ile Gly 
        35                  40                  45              


Lys Pro Lys Pro Tyr Tyr Glu Ile Gly Glu Arg Val Asp Tyr Lys Cys 
    50                  55                  60                  


Lys Lys Gly Tyr Phe Tyr Ile Pro Pro Leu Ala Thr His Thr Ile Cys 
65                  70                  75                  80  


Asp Arg Asn His Thr Trp Leu Pro Val Ser Asp Asp Ala Cys Tyr Arg 
                85                  90                  95      


Glu Thr Cys Pro Tyr Ile Arg Asp Pro Leu Asn Gly Gln Ala Val Pro 
            100                 105                 110         


Ala Asn Gly Thr Tyr Glu Phe Gly Tyr Gln Met His Phe Ile Cys Asn 
        115                 120                 125             


Glu Gly Tyr Tyr Leu Ile Gly Glu Glu Ile Leu Tyr Cys Glu Leu Lys 
    130                 135                 140                 


Gly Ser Val Ala Ile Trp Ser Gly Lys Pro Pro Ile Cys Glu Lys Val 
145                 150                 155                 160 


Leu Cys Thr Pro Pro Pro Lys Ile Lys Asn Gly Lys His Thr Phe Ser 
                165                 170                 175     


Glu Val Glu Val Phe Glu Tyr Leu Asp Ala Val Thr Tyr Ser Cys Asp 
            180                 185                 190         


Pro Ala Pro Gly Pro Asp Pro Phe Ser Leu Ile Gly Glu Ser Thr Ile 
        195                 200                 205             


Tyr Cys Gly Asp Asn Ser Val Trp Ser Arg Ala Ala Pro Glu Cys Lys 
    210                 215                 220                 


Val Val Lys Cys Arg Phe Pro Val Val Glu Asn Gly Lys Gln Ile Ser 
225                 230                 235                 240 


Gly Phe Gly Lys Lys Phe Tyr Tyr Lys Ala Thr Val Met Phe Glu Cys 
                245                 250                 255     


Asp Lys Gly Phe Tyr Leu Asp Gly Ser Asp Thr Ile Val Cys Asp Ser 
            260                 265                 270         


Asn Ser Thr Trp Asp Pro Pro Val Pro Lys Cys Leu Lys Val Leu Pro 
        275                 280                 285             


Pro Ser Ser Thr Lys Pro Pro Ala Leu Ser His Ser Val Ser Thr Ser 
    290                 295                 300                 


Ser Thr Thr Lys Ser Pro Ala Ser Ser Ala Ser Gly Pro Arg Pro Thr 
305                 310                 315                 320 


Tyr Lys Pro Pro Val Ser Asn Tyr Pro Gly Tyr Pro Lys Pro Glu Glu 
                325                 330                 335     


Gly Ile Leu Asp Ser Leu Asp Val Trp Val Ile Ala Val Ile Val Ile 
            340                 345                 350         


Ala Ile Val Val Gly Val Ala Val Ile Cys Val Val Pro Tyr Arg Tyr 
        355                 360                 365             


Leu Gln Arg Arg Lys Lys Lys Gly Thr Tyr Leu Thr Asp Glu Thr His 
    370                 375                 380                 


Arg Glu Val Lys Phe Thr Ser Leu 
385                 390         


<210>  16
<211>  189
<212>  PRT
<213>  Homo sapiens CD46 CCPs 2-4 (UniProt: P15529 residues 97 to 285)

<400>  16

Glu Thr Cys Pro Tyr Ile Arg Asp Pro Leu Asn Gly Gln Ala Val Pro 
1               5                   10                  15      


Ala Asn Gly Thr Tyr Glu Phe Gly Tyr Gln Met His Phe Ile Cys Asn 
            20                  25                  30          


Glu Gly Tyr Tyr Leu Ile Gly Glu Glu Ile Leu Tyr Cys Glu Leu Lys 
        35                  40                  45              


Gly Ser Val Ala Ile Trp Ser Gly Lys Pro Pro Ile Cys Glu Lys Val 
    50                  55                  60                  


Leu Cys Thr Pro Pro Pro Lys Ile Lys Asn Gly Lys His Thr Phe Ser 
65                  70                  75                  80  


Glu Val Glu Val Phe Glu Tyr Leu Asp Ala Val Thr Tyr Ser Cys Asp 
                85                  90                  95      


Pro Ala Pro Gly Pro Asp Pro Phe Ser Leu Ile Gly Glu Ser Thr Ile 
            100                 105                 110         


Tyr Cys Gly Asp Asn Ser Val Trp Ser Arg Ala Ala Pro Glu Cys Lys 
        115                 120                 125             


Val Val Lys Cys Arg Phe Pro Val Val Glu Asn Gly Lys Gln Ile Ser 
    130                 135                 140                 


Gly Phe Gly Lys Lys Phe Tyr Tyr Lys Ala Thr Val Met Phe Glu Cys 
145                 150                 155                 160 


Asp Lys Gly Phe Tyr Leu Asp Gly Ser Asp Thr Ile Val Cys Asp Ser 
                165                 170                 175     


Asn Ser Thr Trp Asp Pro Pro Val Pro Lys Cys Leu Lys 
            180                 185                 


<210>  17
<211>  440
<212>  PRT
<213>  Homo sapiens CD55 (UniProt: P08174)

<400>  17

Met Thr Val Ala Arg Pro Ser Val Pro Ala Ala Leu Pro Leu Leu Gly 
1               5                   10                  15      


Glu Leu Pro Arg Leu Leu Leu Leu Val Leu Leu Cys Leu Pro Ala Val 
            20                  25                  30          


Trp Gly Asp Cys Gly Leu Pro Pro Asp Val Pro Asn Ala Gln Pro Ala 
        35                  40                  45              


Leu Glu Gly Arg Thr Ser Phe Pro Glu Asp Thr Val Ile Thr Tyr Lys 
    50                  55                  60                  


Cys Glu Glu Ser Phe Val Lys Ile Pro Gly Glu Lys Asp Ser Val Ile 
65                  70                  75                  80  


Cys Leu Lys Gly Ser Gln Trp Ser Asp Ile Glu Glu Phe Cys Asn Arg 
                85                  90                  95      


Ser Cys Glu Val Pro Thr Arg Leu Asn Ser Ala Ser Leu Lys Gln Pro 
            100                 105                 110         


Tyr Ile Thr Gln Asn Tyr Phe Pro Val Gly Thr Val Val Glu Tyr Glu 
        115                 120                 125             


Cys Arg Pro Gly Tyr Arg Arg Glu Pro Ser Leu Ser Pro Lys Leu Thr 
    130                 135                 140                 


Cys Leu Gln Asn Leu Lys Trp Ser Thr Ala Val Glu Phe Cys Lys Lys 
145                 150                 155                 160 


Lys Ser Cys Pro Asn Pro Gly Glu Ile Arg Asn Gly Gln Ile Asp Val 
                165                 170                 175     


Pro Gly Gly Ile Leu Phe Gly Ala Thr Ile Ser Phe Ser Cys Asn Thr 
            180                 185                 190         


Gly Tyr Lys Leu Phe Gly Ser Thr Ser Ser Phe Cys Leu Ile Ser Gly 
        195                 200                 205             


Ser Ser Val Gln Trp Ser Asp Pro Leu Pro Glu Cys Arg Glu Ile Tyr 
    210                 215                 220                 


Cys Pro Ala Pro Pro Gln Ile Asp Asn Gly Ile Ile Gln Gly Glu Arg 
225                 230                 235                 240 


Asp His Tyr Gly Tyr Arg Gln Ser Val Thr Tyr Ala Cys Asn Lys Gly 
                245                 250                 255     


Phe Thr Met Ile Gly Glu His Ser Ile Tyr Cys Thr Val Asn Asn Asp 
            260                 265                 270         


Glu Gly Glu Trp Ser Gly Pro Pro Pro Glu Cys Arg Gly Lys Ser Leu 
        275                 280                 285             


Thr Ser Lys Val Pro Pro Thr Val Gln Lys Pro Thr Thr Val Asn Val 
    290                 295                 300                 


Pro Thr Thr Glu Val Ser Pro Thr Ser Gln Lys Thr Thr Thr Lys Thr 
305                 310                 315                 320 


Thr Thr Pro Asn Ala Gln Ala Thr Arg Ser Thr Pro Val Ser Arg Thr 
                325                 330                 335     


Thr Lys His Phe His Glu Thr Thr Pro Asn Lys Gly Ser Gly Thr Thr 
            340                 345                 350         


Ser Gly Thr Thr Arg Leu Leu Ser Gly Ser Arg Pro Val Thr Gln Ala 
        355                 360                 365             


Gly Met Arg Trp Cys Asp Arg Ser Ser Leu Gln Ser Arg Thr Pro Gly 
    370                 375                 380                 


Phe Lys Arg Ser Phe His Phe Ser Leu Pro Ser Ser Trp Tyr Tyr Arg 
385                 390                 395                 400 


Ala His Val Phe His Val Asp Arg Phe Ala Trp Asp Ala Ser Asn His 
                405                 410                 415     


Gly Leu Ala Asp Leu Ala Lys Glu Glu Leu Arg Arg Lys Tyr Thr Gln 
            420                 425                 430         


Val Tyr Arg Leu Phe Leu Val Ser 
        435                 440 


<210>  18
<211>  190
<212>  PRT
<213>  Homo sapiens CD55 CCPs 2-4 (UniProt: P08174 residues 96 to 285)

<400>  18

Arg Ser Cys Glu Val Pro Thr Arg Leu Asn Ser Ala Ser Leu Lys Gln 
1               5                   10                  15      


Pro Tyr Ile Thr Gln Asn Tyr Phe Pro Val Gly Thr Val Val Glu Tyr 
            20                  25                  30          


Glu Cys Arg Pro Gly Tyr Arg Arg Glu Pro Ser Leu Ser Pro Lys Leu 
        35                  40                  45              


Thr Cys Leu Gln Asn Leu Lys Trp Ser Thr Ala Val Glu Phe Cys Lys 
    50                  55                  60                  


Lys Lys Ser Cys Pro Asn Pro Gly Glu Ile Arg Asn Gly Gln Ile Asp 
65                  70                  75                  80  


Val Pro Gly Gly Ile Leu Phe Gly Ala Thr Ile Ser Phe Ser Cys Asn 
                85                  90                  95      


Thr Gly Tyr Lys Leu Phe Gly Ser Thr Ser Ser Phe Cys Leu Ile Ser 
            100                 105                 110         


Gly Ser Ser Val Gln Trp Ser Asp Pro Leu Pro Glu Cys Arg Glu Ile 
        115                 120                 125             


Tyr Cys Pro Ala Pro Pro Gln Ile Asp Asn Gly Ile Ile Gln Gly Glu 
    130                 135                 140                 


Arg Asp His Tyr Gly Tyr Arg Gln Ser Val Thr Tyr Ala Cys Asn Lys 
145                 150                 155                 160 


Gly Phe Thr Met Ile Gly Glu His Ser Ile Tyr Cys Thr Val Asn Asn 
                165                 170                 175     


Asp Glu Gly Glu Trp Ser Gly Pro Pro Pro Glu Cys Arg Gly 
            180                 185                 190 


<210>  19
<211>  597
<212>  PRT
<213>  Homo sapiens C4BP (UniProt: P04003)

<400>  19

Met His Pro Pro Lys Thr Pro Ser Gly Ala Leu His Arg Lys Arg Lys 
1               5                   10                  15      


Met Ala Ala Trp Pro Phe Ser Arg Leu Trp Lys Val Ser Asp Pro Ile 
            20                  25                  30          


Leu Phe Gln Met Thr Leu Ile Ala Ala Leu Leu Pro Ala Val Leu Gly 
        35                  40                  45              


Asn Cys Gly Pro Pro Pro Thr Leu Ser Phe Ala Ala Pro Met Asp Ile 
    50                  55                  60                  


Thr Leu Thr Glu Thr Arg Phe Lys Thr Gly Thr Thr Leu Lys Tyr Thr 
65                  70                  75                  80  


Cys Leu Pro Gly Tyr Val Arg Ser His Ser Thr Gln Thr Leu Thr Cys 
                85                  90                  95      


Asn Ser Asp Gly Glu Trp Val Tyr Asn Thr Phe Cys Ile Tyr Lys Arg 
            100                 105                 110         


Cys Arg His Pro Gly Glu Leu Arg Asn Gly Gln Val Glu Ile Lys Thr 
        115                 120                 125             


Asp Leu Ser Phe Gly Ser Gln Ile Glu Phe Ser Cys Ser Glu Gly Phe 
    130                 135                 140                 


Phe Leu Ile Gly Ser Thr Thr Ser Arg Cys Glu Val Gln Asp Arg Gly 
145                 150                 155                 160 


Val Gly Trp Ser His Pro Leu Pro Gln Cys Glu Ile Val Lys Cys Lys 
                165                 170                 175     


Pro Pro Pro Asp Ile Arg Asn Gly Arg His Ser Gly Glu Glu Asn Phe 
            180                 185                 190         


Tyr Ala Tyr Gly Phe Ser Val Thr Tyr Ser Cys Asp Pro Arg Phe Ser 
        195                 200                 205             


Leu Leu Gly His Ala Ser Ile Ser Cys Thr Val Glu Asn Glu Thr Ile 
    210                 215                 220                 


Gly Val Trp Arg Pro Ser Pro Pro Thr Cys Glu Lys Ile Thr Cys Arg 
225                 230                 235                 240 


Lys Pro Asp Val Ser His Gly Glu Met Val Ser Gly Phe Gly Pro Ile 
                245                 250                 255     


Tyr Asn Tyr Lys Asp Thr Ile Val Phe Lys Cys Gln Lys Gly Phe Val 
            260                 265                 270         


Leu Arg Gly Ser Ser Val Ile His Cys Asp Ala Asp Ser Lys Trp Asn 
        275                 280                 285             


Pro Ser Pro Pro Ala Cys Glu Pro Asn Ser Cys Ile Asn Leu Pro Asp 
    290                 295                 300                 


Ile Pro His Ala Ser Trp Glu Thr Tyr Pro Arg Pro Thr Lys Glu Asp 
305                 310                 315                 320 


Val Tyr Val Val Gly Thr Val Leu Arg Tyr Arg Cys His Pro Gly Tyr 
                325                 330                 335     


Lys Pro Thr Thr Asp Glu Pro Thr Thr Val Ile Cys Gln Lys Asn Leu 
            340                 345                 350         


Arg Trp Thr Pro Tyr Gln Gly Cys Glu Ala Leu Cys Cys Pro Glu Pro 
        355                 360                 365             


Lys Leu Asn Asn Gly Glu Ile Thr Gln His Arg Lys Ser Arg Pro Ala 
    370                 375                 380                 


Asn His Cys Val Tyr Phe Tyr Gly Asp Glu Ile Ser Phe Ser Cys His 
385                 390                 395                 400 


Glu Thr Ser Arg Phe Ser Ala Ile Cys Gln Gly Asp Gly Thr Trp Ser 
                405                 410                 415     


Pro Arg Thr Pro Ser Cys Gly Asp Ile Cys Asn Phe Pro Pro Lys Ile 
            420                 425                 430         


Ala His Gly His Tyr Lys Gln Ser Ser Ser Tyr Ser Phe Phe Lys Glu 
        435                 440                 445             


Glu Ile Ile Tyr Glu Cys Asp Lys Gly Tyr Ile Leu Val Gly Gln Ala 
    450                 455                 460                 


Lys Leu Ser Cys Ser Tyr Ser His Trp Ser Ala Pro Ala Pro Gln Cys 
465                 470                 475                 480 


Lys Ala Leu Cys Arg Lys Pro Glu Leu Val Asn Gly Arg Leu Ser Val 
                485                 490                 495     


Asp Lys Asp Gln Tyr Val Glu Pro Glu Asn Val Thr Ile Gln Cys Asp 
            500                 505                 510         


Ser Gly Tyr Gly Val Val Gly Pro Gln Ser Ile Thr Cys Ser Gly Asn 
        515                 520                 525             


Arg Thr Trp Tyr Pro Glu Val Pro Lys Cys Glu Trp Glu Thr Pro Glu 
    530                 535                 540                 


Gly Cys Glu Gln Val Leu Thr Gly Lys Arg Leu Met Gln Cys Leu Pro 
545                 550                 555                 560 


Asn Pro Glu Asp Val Lys Met Ala Leu Glu Val Tyr Lys Leu Ser Leu 
                565                 570                 575     


Glu Ile Glu Gln Leu Glu Leu Gln Arg Asp Ser Ala Arg Gln Ser Thr 
            580                 585                 590         


Leu Asp Lys Glu Leu 
        595         


<210>  20
<211>  186
<212>  PRT
<213>  Homo sapiens C4BP CCPs 2-4 (UniProt: P04003 residues 111 to 296)

<400>  20

Lys Arg Cys Arg His Pro Gly Glu Leu Arg Asn Gly Gln Val Glu Ile 
1               5                   10                  15      


Lys Thr Asp Leu Ser Phe Gly Ser Gln Ile Glu Phe Ser Cys Ser Glu 
            20                  25                  30          


Gly Phe Phe Leu Ile Gly Ser Thr Thr Ser Arg Cys Glu Val Gln Asp 
        35                  40                  45              


Arg Gly Val Gly Trp Ser His Pro Leu Pro Gln Cys Glu Ile Val Lys 
    50                  55                  60                  


Cys Lys Pro Pro Pro Asp Ile Arg Asn Gly Arg His Ser Gly Glu Glu 
65                  70                  75                  80  


Asn Phe Tyr Ala Tyr Gly Phe Ser Val Thr Tyr Ser Cys Asp Pro Arg 
                85                  90                  95      


Phe Ser Leu Leu Gly His Ala Ser Ile Ser Cys Thr Val Glu Asn Glu 
            100                 105                 110         


Thr Ile Gly Val Trp Arg Pro Ser Pro Pro Thr Cys Glu Lys Ile Thr 
        115                 120                 125             


Cys Arg Lys Pro Asp Val Ser His Gly Glu Met Val Ser Gly Phe Gly 
    130                 135                 140                 


Pro Ile Tyr Asn Tyr Lys Asp Thr Ile Val Phe Lys Cys Gln Lys Gly 
145                 150                 155                 160 


Phe Val Leu Arg Gly Ser Ser Val Ile His Cys Asp Ala Asp Ser Lys 
                165                 170                 175     


Trp Asn Pro Ser Pro Pro Ala Cys Glu Pro 
            180                 185     


<210>  21
<211>  245
<212>  PRT
<213>  Homo sapiens SPICE (PDB: 5FOB_C)

<400>  21

Ser Cys Cys Thr Ile Pro Ser Arg Pro Ile Asn Met Lys Phe Lys Asn 
1               5                   10                  15      


Ser Val Glu Thr Asp Ala Asn Ala Asn Tyr Asn Ile Gly Asp Thr Ile 
            20                  25                  30          


Glu Tyr Leu Cys Leu Pro Gly Tyr Arg Lys Gln Lys Met Gly Pro Ile 
        35                  40                  45              


Tyr Ala Lys Cys Thr Gly Thr Gly Trp Thr Leu Phe Asn Gln Cys Ile 
    50                  55                  60                  


Lys Arg Arg Cys Pro Ser Pro Arg Asp Ile Asp Asn Gly His Leu Asp 
65                  70                  75                  80  


Ile Gly Gly Val Asp Phe Gly Ser Ser Ile Thr Tyr Ser Cys Asn Ser 
                85                  90                  95      


Gly Tyr Tyr Leu Ile Gly Glu Tyr Lys Ser Tyr Cys Lys Leu Gly Ser 
            100                 105                 110         


Thr Gly Ser Met Val Trp Asn Pro Lys Ala Pro Ile Cys Glu Ser Val 
        115                 120                 125             


Lys Cys Gln Leu Pro Pro Ser Ile Ser Asn Gly Arg His Asn Gly Tyr 
    130                 135                 140                 


Asn Asp Phe Tyr Thr Asp Gly Ser Val Val Thr Tyr Ser Cys Asn Ser 
145                 150                 155                 160 


Gly Tyr Ser Leu Ile Gly Asn Ser Gly Val Leu Cys Ser Gly Gly Glu 
                165                 170                 175     


Trp Ser Asn Pro Pro Thr Cys Gln Ile Val Lys Cys Pro His Pro Thr 
            180                 185                 190         


Ile Leu Asn Gly Tyr Leu Ser Ser Gly Phe Lys Arg Ser Tyr Ser Tyr 
        195                 200                 205             


Asn Asp Asn Val Asp Phe Thr Cys Lys Tyr Gly Tyr Lys Leu Ser Gly 
    210                 215                 220                 


Ser Ser Ser Ser Thr Cys Ser Pro Gly Asn Thr Trp Gln Pro Glu Leu 
225                 230                 235                 240 


Pro Lys Cys Val Arg 
                245 


<210>  22
<211>  263
<212>  PRT
<213>  Homo sapiens VCP (NCBI: YP_232907.1)

<400>  22

Met Lys Val Glu Ser Val Thr Phe Leu Thr Leu Leu Gly Ile Gly Cys 
1               5                   10                  15      


Val Leu Ser Cys Cys Thr Ile Pro Ser Arg Pro Ile Asn Met Lys Phe 
            20                  25                  30          


Lys Asn Ser Val Glu Thr Asp Ala Asn Ala Asn Tyr Asn Ile Gly Asp 
        35                  40                  45              


Thr Ile Glu Tyr Leu Cys Leu Pro Gly Tyr Arg Lys Gln Lys Met Gly 
    50                  55                  60                  


Pro Ile Tyr Ala Lys Cys Thr Gly Thr Gly Trp Thr Leu Phe Asn Gln 
65                  70                  75                  80  


Cys Ile Lys Arg Arg Cys Pro Ser Pro Arg Asp Ile Asp Asn Gly Gln 
                85                  90                  95      


Leu Asp Ile Gly Gly Val Asp Phe Gly Ser Ser Ile Thr Tyr Ser Cys 
            100                 105                 110         


Asn Ser Gly Tyr His Leu Ile Gly Glu Ser Lys Ser Tyr Cys Glu Leu 
        115                 120                 125             


Gly Ser Thr Gly Ser Met Val Trp Asn Pro Glu Ala Pro Ile Cys Glu 
    130                 135                 140                 


Ser Val Lys Cys Gln Ser Pro Pro Ser Ile Ser Asn Gly Arg His Asn 
145                 150                 155                 160 


Gly Tyr Glu Asp Phe Tyr Thr Asp Gly Ser Val Val Thr Tyr Ser Cys 
                165                 170                 175     


Asn Ser Gly Tyr Ser Leu Ile Gly Asn Ser Gly Val Leu Cys Ser Gly 
            180                 185                 190         


Gly Glu Trp Ser Asp Pro Pro Thr Cys Gln Ile Val Lys Cys Pro His 
        195                 200                 205             


Pro Thr Ile Ser Asn Gly Tyr Leu Ser Ser Gly Phe Lys Arg Ser Tyr 
    210                 215                 220                 


Ser Tyr Asn Asp Asn Val Asp Phe Lys Cys Lys Tyr Gly Tyr Lys Leu 
225                 230                 235                 240 


Ser Gly Ser Ser Ser Ser Thr Cys Ser Pro Gly Asn Thr Trp Lys Pro 
                245                 250                 255     


Glu Leu Pro Lys Cys Val Arg 
            260             


<210>  23
<211>  216
<212>  PRT
<213>  Homo sapiens MOPICE (GenBank: AAV84857.1)

<400>  23

Met Lys Val Glu Ser Val Thr Phe Leu Thr Leu Leu Gly Ile Gly Cys 
1               5                   10                  15      


Val Leu Ser Tyr Cys Thr Ile Pro Ser Arg Pro Ile Asn Met Lys Phe 
            20                  25                  30          


Lys Asn Ser Val Glu Thr Asp Ala Asn Tyr Asn Ile Gly Asp Thr Ile 
        35                  40                  45              


Glu Tyr Leu Cys Leu Pro Gly Tyr Arg Lys Gln Lys Met Gly Pro Ile 
    50                  55                  60                  


Tyr Ala Lys Cys Thr Gly Thr Gly Trp Thr Leu Phe Asn Gln Cys Ile 
65                  70                  75                  80  


Lys Arg Arg Cys Pro Ser Pro Arg Asp Ile Asp Asn Gly Gln Leu Asp 
                85                  90                  95      


Ile Gly Gly Val Asp Phe Gly Ser Ser Ile Thr Tyr Ser Cys Asn Ser 
            100                 105                 110         


Gly Tyr His Leu Ile Gly Glu Ser Lys Ser Tyr Cys Glu Leu Gly Ser 
        115                 120                 125             


Thr Gly Ser Met Val Trp Asn Pro Glu Ala Pro Ile Cys Glu Ser Val 
    130                 135                 140                 


Lys Cys Gln Ser Pro Pro Ser Ile Ser Asn Gly Arg His Asn Gly Tyr 
145                 150                 155                 160 


Glu Asp Phe Tyr Ile Asp Gly Ser Ile Val Thr Tyr Ser Cys Asn Ser 
                165                 170                 175     


Gly Tyr Ser Leu Ile Gly Asn Ser Gly Val Met Cys Ser Gly Gly Glu 
            180                 185                 190         


Trp Ser Asn Pro Pro Thr Cys Gln Ile Val Lys Cys Pro His Pro Ile 
        195                 200                 205             


Ser Asn Gly Lys Leu Leu Ala Ala 
    210                 215     


<210>  24
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  G4S-R-(G4S)2 linker

<400>  24

Gly Gly Gly Gly Ser Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15      


<210>  25
<211>  967
<212>  PRT
<213>  Homo sapiens Complement Factor H residues 264-1231

<400>  25

Lys Ser Cys Asp Asn Pro Tyr Ile Pro Asn Gly Asp Tyr Ser Pro Leu 
1               5                   10                  15      


Arg Ile Lys His Arg Thr Gly Asp Glu Ile Thr Tyr Gln Cys Arg Asn 
            20                  25                  30          


Gly Phe Tyr Pro Ala Thr Arg Gly Asn Thr Ala Lys Cys Thr Ser Thr 
        35                  40                  45              


Gly Trp Ile Pro Ala Pro Arg Cys Thr Leu Lys Pro Cys Asp Tyr Pro 
    50                  55                  60                  


Asp Ile Lys His Gly Gly Leu Tyr His Glu Asn Met Arg Arg Pro Tyr 
65                  70                  75                  80  


Phe Pro Val Ala Val Gly Lys Tyr Tyr Ser Tyr Tyr Cys Asp Glu His 
                85                  90                  95      


Phe Glu Thr Pro Ser Gly Ser Tyr Trp Asp His Ile His Cys Thr Gln 
            100                 105                 110         


Asp Gly Trp Ser Pro Ala Val Pro Cys Leu Arg Lys Cys Tyr Phe Pro 
        115                 120                 125             


Tyr Leu Glu Asn Gly Tyr Asn Gln Asn Tyr Gly Arg Lys Phe Val Gln 
    130                 135                 140                 


Gly Lys Ser Ile Asp Val Ala Cys His Pro Gly Tyr Ala Leu Pro Lys 
145                 150                 155                 160 


Ala Gln Thr Thr Val Thr Cys Met Glu Asn Gly Trp Ser Pro Thr Pro 
                165                 170                 175     


Arg Cys Ile Arg Val Lys Thr Cys Ser Lys Ser Ser Ile Asp Ile Glu 
            180                 185                 190         


Asn Gly Phe Ile Ser Glu Ser Gln Tyr Thr Tyr Ala Leu Lys Glu Lys 
        195                 200                 205             


Ala Lys Tyr Gln Cys Lys Leu Gly Tyr Val Thr Ala Asp Gly Glu Thr 
    210                 215                 220                 


Ser Gly Ser Ile Thr Cys Gly Lys Asp Gly Trp Ser Ala Gln Pro Thr 
225                 230                 235                 240 


Cys Ile Lys Ser Cys Asp Ile Pro Val Phe Met Asn Ala Arg Thr Lys 
                245                 250                 255     


Asn Asp Phe Thr Trp Phe Lys Leu Asn Asp Thr Leu Asp Tyr Glu Cys 
            260                 265                 270         


His Asp Gly Tyr Glu Ser Asn Thr Gly Ser Thr Thr Gly Ser Ile Val 
        275                 280                 285             


Cys Gly Tyr Asn Gly Trp Ser Asp Leu Pro Ile Cys Tyr Glu Arg Glu 
    290                 295                 300                 


Cys Glu Leu Pro Lys Ile Asp Val His Leu Val Pro Asp Arg Lys Lys 
305                 310                 315                 320 


Asp Gln Tyr Lys Val Gly Glu Val Leu Lys Phe Ser Cys Lys Pro Gly 
                325                 330                 335     


Phe Thr Ile Val Gly Pro Asn Ser Val Gln Cys Tyr His Phe Gly Leu 
            340                 345                 350         


Ser Pro Asp Leu Pro Ile Cys Lys Glu Gln Val Gln Ser Cys Gly Pro 
        355                 360                 365             


Pro Pro Glu Leu Leu Asn Gly Asn Val Lys Glu Lys Thr Lys Glu Glu 
    370                 375                 380                 


Tyr Gly His Ser Glu Val Val Glu Tyr Tyr Cys Asn Pro Arg Phe Leu 
385                 390                 395                 400 


Met Lys Gly Pro Asn Lys Ile Gln Cys Val Asp Gly Glu Trp Thr Thr 
                405                 410                 415     


Leu Pro Val Cys Ile Val Glu Glu Ser Thr Cys Gly Asp Ile Pro Glu 
            420                 425                 430         


Leu Glu His Gly Trp Ala Gln Leu Ser Ser Pro Pro Tyr Tyr Tyr Gly 
        435                 440                 445             


Asp Ser Val Glu Phe Asn Cys Ser Glu Ser Phe Thr Met Ile Gly His 
    450                 455                 460                 


Arg Ser Ile Thr Cys Ile His Gly Val Trp Thr Gln Leu Pro Gln Cys 
465                 470                 475                 480 


Val Ala Ile Asp Lys Leu Lys Lys Cys Lys Ser Ser Asn Leu Ile Ile 
                485                 490                 495     


Leu Glu Glu His Leu Lys Asn Lys Lys Glu Phe Asp His Asn Ser Asn 
            500                 505                 510         


Ile Arg Tyr Arg Cys Arg Gly Lys Glu Gly Trp Ile His Thr Val Cys 
        515                 520                 525             


Ile Asn Gly Arg Trp Asp Pro Glu Val Asn Cys Ser Met Ala Gln Ile 
    530                 535                 540                 


Gln Leu Cys Pro Pro Pro Pro Gln Ile Pro Asn Ser His Asn Met Thr 
545                 550                 555                 560 


Thr Thr Leu Asn Tyr Arg Asp Gly Glu Lys Val Ser Val Leu Cys Gln 
                565                 570                 575     


Glu Asn Tyr Leu Ile Gln Glu Gly Glu Glu Ile Thr Cys Lys Asp Gly 
            580                 585                 590         


Arg Trp Gln Ser Ile Pro Leu Cys Val Glu Lys Ile Pro Cys Ser Gln 
        595                 600                 605             


Pro Pro Gln Ile Glu His Gly Thr Ile Asn Ser Ser Arg Ser Ser Gln 
    610                 615                 620                 


Glu Ser Tyr Ala His Gly Thr Lys Leu Ser Tyr Thr Cys Glu Gly Gly 
625                 630                 635                 640 


Phe Arg Ile Ser Glu Glu Asn Glu Thr Thr Cys Tyr Met Gly Lys Trp 
                645                 650                 655     


Ser Ser Pro Pro Gln Cys Glu Gly Leu Pro Cys Lys Ser Pro Pro Glu 
            660                 665                 670         


Ile Ser His Gly Val Val Ala His Met Ser Asp Ser Tyr Gln Tyr Gly 
        675                 680                 685             


Glu Glu Val Thr Tyr Lys Cys Phe Glu Gly Phe Gly Ile Asp Gly Pro 
    690                 695                 700                 


Ala Ile Ala Lys Cys Leu Gly Glu Lys Trp Ser His Pro Pro Ser Cys 
705                 710                 715                 720 


Ile Lys Thr Asp Cys Leu Ser Leu Pro Ser Phe Glu Asn Ala Ile Pro 
                725                 730                 735     


Met Gly Glu Lys Lys Asp Val Tyr Lys Ala Gly Glu Gln Val Thr Tyr 
            740                 745                 750         


Thr Cys Ala Thr Tyr Tyr Lys Met Asp Gly Ala Ser Asn Val Thr Cys 
        755                 760                 765             


Ile Asn Ser Arg Trp Thr Gly Arg Pro Thr Cys Arg Asp Thr Ser Cys 
    770                 775                 780                 


Val Asn Pro Pro Thr Val Gln Asn Ala Tyr Ile Val Ser Arg Gln Met 
785                 790                 795                 800 


Ser Lys Tyr Pro Ser Gly Glu Arg Val Arg Tyr Gln Cys Arg Ser Pro 
                805                 810                 815     


Tyr Glu Met Phe Gly Asp Glu Glu Val Met Cys Leu Asn Gly Asn Trp 
            820                 825                 830         


Thr Glu Pro Pro Gln Cys Lys Asp Ser Thr Gly Lys Cys Gly Pro Pro 
        835                 840                 845             


Pro Pro Ile Asp Asn Gly Asp Ile Thr Ser Phe Pro Leu Ser Val Tyr 
    850                 855                 860                 


Ala Pro Ala Ser Ser Val Glu Tyr Gln Cys Gln Asn Leu Tyr Gln Leu 
865                 870                 875                 880 


Glu Gly Asn Lys Arg Ile Thr Cys Arg Asn Gly Gln Trp Ser Glu Pro 
                885                 890                 895     


Pro Lys Cys Leu His Pro Cys Val Ile Ser Arg Glu Ile Met Glu Asn 
            900                 905                 910         


Tyr Asn Ile Ala Leu Arg Trp Thr Ala Lys Gln Lys Leu Tyr Ser Arg 
        915                 920                 925             


Thr Gly Glu Ser Val Glu Phe Val Cys Lys Arg Gly Tyr Arg Leu Ser 
    930                 935                 940                 


Ser Arg Ser His Thr Leu Arg Thr Thr Cys Trp Asp Gly Lys Leu Glu 
945                 950                 955                 960 


Tyr Pro Thr Cys Ala Lys Arg 
                965         


<210>  26
<211>  339
<212>  PRT
<213>  Homo sapiens Complement Factor I residues 1 to 339

<400>  26

Met Lys Leu Leu His Val Phe Leu Leu Phe Leu Cys Phe His Leu Arg 
1               5                   10                  15      


Phe Cys Lys Val Thr Tyr Thr Ser Gln Glu Asp Leu Val Glu Lys Lys 
            20                  25                  30          


Cys Leu Ala Lys Lys Tyr Thr His Leu Ser Cys Asp Lys Val Phe Cys 
        35                  40                  45              


Gln Pro Trp Gln Arg Cys Ile Glu Gly Thr Cys Val Cys Lys Leu Pro 
    50                  55                  60                  


Tyr Gln Cys Pro Lys Asn Gly Thr Ala Val Cys Ala Thr Asn Arg Arg 
65                  70                  75                  80  


Ser Phe Pro Thr Tyr Cys Gln Gln Lys Ser Leu Glu Cys Leu His Pro 
                85                  90                  95      


Gly Thr Lys Phe Leu Asn Asn Gly Thr Cys Thr Ala Glu Gly Lys Phe 
            100                 105                 110         


Ser Val Ser Leu Lys His Gly Asn Thr Asp Ser Glu Gly Ile Val Glu 
        115                 120                 125             


Val Lys Leu Val Asp Gln Asp Lys Thr Met Phe Ile Cys Lys Ser Ser 
    130                 135                 140                 


Trp Ser Met Arg Glu Ala Asn Val Ala Cys Leu Asp Leu Gly Phe Gln 
145                 150                 155                 160 


Gln Gly Ala Asp Thr Gln Arg Arg Phe Lys Leu Ser Asp Leu Ser Ile 
                165                 170                 175     


Asn Ser Thr Glu Cys Leu His Val His Cys Arg Gly Leu Glu Thr Ser 
            180                 185                 190         


Leu Ala Glu Cys Thr Phe Thr Lys Arg Arg Thr Met Gly Tyr Gln Asp 
        195                 200                 205             


Phe Ala Asp Val Val Cys Tyr Thr Gln Lys Ala Asp Ser Pro Met Asp 
    210                 215                 220                 


Asp Phe Phe Gln Cys Val Asn Gly Lys Tyr Ile Ser Gln Met Lys Ala 
225                 230                 235                 240 


Cys Asp Gly Ile Asn Asp Cys Gly Asp Gln Ser Asp Glu Leu Cys Cys 
                245                 250                 255     


Lys Ala Cys Gln Gly Lys Gly Phe His Cys Lys Ser Gly Val Cys Ile 
            260                 265                 270         


Pro Ser Gln Tyr Gln Cys Asn Gly Glu Val Asp Cys Ile Thr Gly Glu 
        275                 280                 285             


Asp Glu Val Gly Cys Ala Gly Phe Ala Ser Val Thr Gln Glu Glu Thr 
    290                 295                 300                 


Glu Ile Leu Thr Ala Asp Met Asp Ala Glu Arg Arg Arg Ile Lys Ser 
305                 310                 315                 320 


Leu Leu Pro Lys Leu Ser Cys Gly Val Lys Asn Arg Met His Ile Arg 
                325                 330                 335     


Arg Lys Arg 
            


<210>  27
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Consensus sequence for N-linked glycosylation


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = any amino acid except for P

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa = S or T

<400>  27

Asn Xaa Xaa 
1           


<210>  28
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Furin endopeptidase cleavage site (minimal)


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = any amino acid

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa = any amino acid

<400>  28

Arg Xaa Xaa Arg 
1               


<210>  29
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Furin endopeptidase cleavage site (preferred)


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = any amino acid

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa = K or R

<400>  29

Arg Xaa Xaa Arg 
1               


<210>  30
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  6xHis tag

<400>  30

His His His His His His 
1               5       


<210>  31
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Tobacco Etch Virus (TEV) protease cleavage site

<400>  31

Glu Asn Leu Tyr Phe Gln Gly 
1               5           


<210>  32
<211>  543
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  His-tagged glycosylated chimeric FH-FI protein amino acid 
       sequence

<400>  32

Met Arg Leu Leu Ala Lys Ile Ile Cys Leu Met Leu Trp Ala Ile Cys 
1               5                   10                  15      


Val Ala His His His His His His Gly Ser Ser Glu Asn Leu Tyr Phe 
            20                  25                  30          


Gln Gly Ser Ser Gly Glu Asp Cys Asn Glu Leu Pro Pro Arg Arg Asn 
        35                  40                  45              


Thr Glu Ile Leu Thr Gly Ser Trp Ser Asp Gln Thr Tyr Pro Glu Gly 
    50                  55                  60                  


Thr Gln Ala Ile Tyr Lys Cys Arg Pro Gly Tyr Arg Ser Leu Gly Asn 
65                  70                  75                  80  


Ile Ile Met Val Cys Arg Lys Gly Glu Trp Val Ala Leu Asn Pro Leu 
                85                  90                  95      


Arg Lys Cys Gln Lys Arg Pro Cys Gly His Pro Gly Asp Thr Pro Phe 
            100                 105                 110         


Gly Thr Phe Thr Leu Thr Gly Gly Asn Val Phe Glu Tyr Gly Val Lys 
        115                 120                 125             


Ala Val Tyr Thr Cys Asn Glu Gly Tyr Gln Leu Leu Gly Glu Ile Asn 
    130                 135                 140                 


Tyr Arg Glu Cys Asp Thr Asp Gly Trp Thr Asn Asp Ile Pro Ile Cys 
145                 150                 155                 160 


Glu Val Val Lys Cys Leu Pro Val Thr Ala Pro Glu Asn Gly Lys Ile 
                165                 170                 175     


Val Ser Ser Ala Met Glu Pro Asp Arg Glu Tyr His Phe Gly Gln Ala 
            180                 185                 190         


Val Arg Phe Val Cys Asn Ser Gly Tyr Lys Ile Glu Gly Asp Glu Glu 
        195                 200                 205             


Met His Cys Ser Asp Asp Gly Phe Trp Ser Lys Glu Lys Pro Lys Cys 
    210                 215                 220                 


Val Glu Ile Ser Cys Lys Ser Pro Asp Val Ile Asn Gly Ser Pro Ile 
225                 230                 235                 240 


Ser Gln Lys Ile Ile Tyr Lys Glu Asn Glu Arg Phe Gln Tyr Lys Cys 
                245                 250                 255     


Asn Met Gly Tyr Glu Tyr Ser Glu Arg Gly Asp Ala Val Cys Thr Glu 
            260                 265                 270         


Ser Gly Trp Arg Pro Leu Pro Ser Cys Glu Glu Gly Gly Gly Gly Ser 
        275                 280                 285             


Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ile Val Gly Gly Lys 
    290                 295                 300                 


Arg Ala Gln Leu Gly Asp Leu Pro Trp Gln Val Ala Ile Lys Asp Ala 
305                 310                 315                 320 


Ser Gly Ile Thr Cys Gly Gly Ile Tyr Ile Gly Gly Cys Trp Ile Leu 
                325                 330                 335     


Thr Ala Ala His Cys Leu Arg Ala Ser Lys Thr His Arg Tyr Gln Ile 
            340                 345                 350         


Trp Thr Thr Val Val Asp Trp Ile His Pro Asp Leu Lys Arg Ile Val 
        355                 360                 365             


Ile Glu Tyr Val Asp Arg Ile Ile Phe His Glu Asn Tyr Asn Ala Gly 
    370                 375                 380                 


Thr Tyr Gln Asn Asp Ile Ala Leu Ile Glu Met Lys Lys Asp Gly Asn 
385                 390                 395                 400 


Lys Lys Asp Cys Glu Leu Pro Arg Ser Ile Pro Ala Ala Val Pro Trp 
                405                 410                 415     


Ser Pro Tyr Leu Phe Gln Pro Asn Asp Thr Cys Ile Val Ser Gly Trp 
            420                 425                 430         


Gly Arg Glu Lys Asp Asn Glu Arg Val Phe Ser Leu Gln Trp Gly Glu 
        435                 440                 445             


Val Lys Leu Ile Ser Asn Cys Ser Lys Phe Tyr Gly Asn Arg Phe Tyr 
    450                 455                 460                 


Glu Lys Glu Met Glu Cys Ala Gly Thr Tyr Asp Gly Ser Ile Asp Ala 
465                 470                 475                 480 


Cys Lys Gly Asp Ser Gly Gly Pro Leu Val Cys Met Asp Ala Asn Asn 
                485                 490                 495     


Val Thr Tyr Val Trp Gly Val Val Ser Trp Gly Glu Asn Cys Gly Lys 
            500                 505                 510         


Pro Glu Phe Pro Gly Val Tyr Thr Lys Val Ala Asn Tyr Phe Asp Trp 
        515                 520                 525             


Ile Ser Tyr His Val Gly Arg Pro Phe Ile Ser Gln Tyr Asn Val 
    530                 535                 540             


<210>  33
<211>  543
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  His-tagged non-glycosylated chimeric FH-FI protein amino acid 
       sequence

<400>  33

Met Arg Leu Leu Ala Lys Ile Ile Cys Leu Met Leu Trp Ala Ile Cys 
1               5                   10                  15      


Val Ala His His His His His His Gly Ser Ser Glu Asn Leu Tyr Phe 
            20                  25                  30          


Gln Gly Ser Ser Gly Glu Asp Cys Asn Glu Leu Pro Pro Arg Arg Asn 
        35                  40                  45              


Thr Glu Ile Leu Thr Gly Ser Trp Ser Asp Gln Thr Tyr Pro Glu Gly 
    50                  55                  60                  


Thr Gln Ala Ile Tyr Lys Cys Arg Pro Gly Tyr Arg Ser Leu Gly Asn 
65                  70                  75                  80  


Ile Ile Met Val Cys Arg Lys Gly Glu Trp Val Ala Leu Asn Pro Leu 
                85                  90                  95      


Arg Lys Cys Gln Lys Arg Pro Cys Gly His Pro Gly Asp Thr Pro Phe 
            100                 105                 110         


Gly Thr Phe Thr Leu Thr Gly Gly Asn Val Phe Glu Tyr Gly Val Lys 
        115                 120                 125             


Ala Val Tyr Thr Cys Asn Glu Gly Tyr Gln Leu Leu Gly Glu Ile Asn 
    130                 135                 140                 


Tyr Arg Glu Cys Asp Thr Asp Gly Trp Thr Asn Asp Ile Pro Ile Cys 
145                 150                 155                 160 


Glu Val Val Lys Cys Leu Pro Val Thr Ala Pro Glu Asn Gly Lys Ile 
                165                 170                 175     


Val Ser Ser Ala Met Glu Pro Asp Arg Glu Tyr His Phe Gly Gln Ala 
            180                 185                 190         


Val Arg Phe Val Cys Asn Ser Gly Tyr Lys Ile Glu Gly Asp Glu Glu 
        195                 200                 205             


Met His Cys Ser Asp Asp Gly Phe Trp Ser Lys Glu Lys Pro Lys Cys 
    210                 215                 220                 


Val Glu Ile Ser Cys Lys Ser Pro Asp Val Ile Asn Gly Ser Pro Ile 
225                 230                 235                 240 


Ser Gln Lys Ile Ile Tyr Lys Glu Asn Glu Arg Phe Gln Tyr Lys Cys 
                245                 250                 255     


Asn Met Gly Tyr Glu Tyr Ser Glu Arg Gly Asp Ala Val Cys Thr Glu 
            260                 265                 270         


Ser Gly Trp Arg Pro Leu Pro Ser Cys Glu Glu Gly Gly Gly Gly Ser 
        275                 280                 285             


Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ile Val Gly Gly Lys 
    290                 295                 300                 


Arg Ala Gln Leu Gly Asp Leu Pro Trp Gln Val Ala Ile Lys Asp Ala 
305                 310                 315                 320 


Ser Gly Ile Thr Cys Gly Gly Ile Tyr Ile Gly Gly Cys Trp Ile Leu 
                325                 330                 335     


Thr Ala Ala His Cys Leu Arg Ala Ser Lys Thr His Arg Tyr Gln Ile 
            340                 345                 350         


Trp Thr Thr Val Val Asp Trp Ile His Pro Asp Leu Lys Arg Ile Val 
        355                 360                 365             


Ile Glu Tyr Val Asp Arg Ile Ile Phe His Glu Asn Tyr Asn Ala Gly 
    370                 375                 380                 


Thr Tyr Gln Asn Asp Ile Ala Leu Ile Glu Met Lys Lys Asp Gly Asn 
385                 390                 395                 400 


Lys Lys Asp Cys Glu Leu Pro Arg Ser Ile Pro Ala Ala Val Pro Trp 
                405                 410                 415     


Ser Pro Tyr Leu Phe Gln Pro Gln Asp Thr Cys Ile Val Ser Gly Trp 
            420                 425                 430         


Gly Arg Glu Lys Asp Asn Glu Arg Val Phe Ser Leu Gln Trp Gly Glu 
        435                 440                 445             


Val Lys Leu Ile Ser Gln Cys Ser Lys Phe Tyr Gly Asn Arg Phe Tyr 
    450                 455                 460                 


Glu Lys Glu Met Glu Cys Ala Gly Thr Tyr Asp Gly Ser Ile Asp Ala 
465                 470                 475                 480 


Cys Lys Gly Asp Ser Gly Gly Pro Leu Val Cys Met Asp Ala Asn Gln 
                485                 490                 495     


Val Thr Tyr Val Trp Gly Val Val Ser Trp Gly Glu Asn Cys Gly Lys 
            500                 505                 510         


Pro Glu Phe Pro Gly Val Tyr Thr Lys Val Ala Asn Tyr Phe Asp Trp 
        515                 520                 525             


Ile Ser Tyr His Val Gly Arg Pro Phe Ile Ser Gln Tyr Asn Val 
    530                 535                 540             


<210>  34
<211>  524
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  non-glycosylated chimeric FH-FI protein amino acid sequence

<400>  34

Met Arg Leu Leu Ala Lys Ile Ile Cys Leu Met Leu Trp Ala Ile Cys 
1               5                   10                  15      


Val Ala Glu Asp Cys Asn Glu Leu Pro Pro Arg Arg Asn Thr Glu Ile 
            20                  25                  30          


Leu Thr Gly Ser Trp Ser Asp Gln Thr Tyr Pro Glu Gly Thr Gln Ala 
        35                  40                  45              


Ile Tyr Lys Cys Arg Pro Gly Tyr Arg Ser Leu Gly Asn Ile Ile Met 
    50                  55                  60                  


Val Cys Arg Lys Gly Glu Trp Val Ala Leu Asn Pro Leu Arg Lys Cys 
65                  70                  75                  80  


Gln Lys Arg Pro Cys Gly His Pro Gly Asp Thr Pro Phe Gly Thr Phe 
                85                  90                  95      


Thr Leu Thr Gly Gly Asn Val Phe Glu Tyr Gly Val Lys Ala Val Tyr 
            100                 105                 110         


Thr Cys Asn Glu Gly Tyr Gln Leu Leu Gly Glu Ile Asn Tyr Arg Glu 
        115                 120                 125             


Cys Asp Thr Asp Gly Trp Thr Asn Asp Ile Pro Ile Cys Glu Val Val 
    130                 135                 140                 


Lys Cys Leu Pro Val Thr Ala Pro Glu Asn Gly Lys Ile Val Ser Ser 
145                 150                 155                 160 


Ala Met Glu Pro Asp Arg Glu Tyr His Phe Gly Gln Ala Val Arg Phe 
                165                 170                 175     


Val Cys Asn Ser Gly Tyr Lys Ile Glu Gly Asp Glu Glu Met His Cys 
            180                 185                 190         


Ser Asp Asp Gly Phe Trp Ser Lys Glu Lys Pro Lys Cys Val Glu Ile 
        195                 200                 205             


Ser Cys Lys Ser Pro Asp Val Ile Asn Gly Ser Pro Ile Ser Gln Lys 
    210                 215                 220                 


Ile Ile Tyr Lys Glu Asn Glu Arg Phe Gln Tyr Lys Cys Asn Met Gly 
225                 230                 235                 240 


Tyr Glu Tyr Ser Glu Arg Gly Asp Ala Val Cys Thr Glu Ser Gly Trp 
                245                 250                 255     


Arg Pro Leu Pro Ser Cys Glu Glu Gly Gly Gly Gly Ser Arg Gly Gly 
            260                 265                 270         


Gly Gly Ser Gly Gly Gly Gly Ser Ile Val Gly Gly Lys Arg Ala Gln 
        275                 280                 285             


Leu Gly Asp Leu Pro Trp Gln Val Ala Ile Lys Asp Ala Ser Gly Ile 
    290                 295                 300                 


Thr Cys Gly Gly Ile Tyr Ile Gly Gly Cys Trp Ile Leu Thr Ala Ala 
305                 310                 315                 320 


His Cys Leu Arg Ala Ser Lys Thr His Arg Tyr Gln Ile Trp Thr Thr 
                325                 330                 335     


Val Val Asp Trp Ile His Pro Asp Leu Lys Arg Ile Val Ile Glu Tyr 
            340                 345                 350         


Val Asp Arg Ile Ile Phe His Glu Asn Tyr Asn Ala Gly Thr Tyr Gln 
        355                 360                 365             


Asn Asp Ile Ala Leu Ile Glu Met Lys Lys Asp Gly Asn Lys Lys Asp 
    370                 375                 380                 


Cys Glu Leu Pro Arg Ser Ile Pro Ala Ala Val Pro Trp Ser Pro Tyr 
385                 390                 395                 400 


Leu Phe Gln Pro Gln Asp Thr Cys Ile Val Ser Gly Trp Gly Arg Glu 
                405                 410                 415     


Lys Asp Asn Glu Arg Val Phe Ser Leu Gln Trp Gly Glu Val Lys Leu 
            420                 425                 430         


Ile Ser Gln Cys Ser Lys Phe Tyr Gly Asn Arg Phe Tyr Glu Lys Glu 
        435                 440                 445             


Met Glu Cys Ala Gly Thr Tyr Asp Gly Ser Ile Asp Ala Cys Lys Gly 
    450                 455                 460                 


Asp Ser Gly Gly Pro Leu Val Cys Met Asp Ala Asn Gln Val Thr Tyr 
465                 470                 475                 480 


Val Trp Gly Val Val Ser Trp Gly Glu Asn Cys Gly Lys Pro Glu Phe 
                485                 490                 495     


Pro Gly Val Tyr Thr Lys Val Ala Asn Tyr Phe Asp Trp Ile Ser Tyr 
            500                 505                 510         


His Val Gly Arg Pro Phe Ile Ser Gln Tyr Asn Val 
        515                 520                 


<210>  35
<211>  525
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  His-tagged glycosylated chimeric FH-FI protein amino acid 
       sequence (without signal peptide)

<400>  35

His His His His His His Gly Ser Ser Glu Asn Leu Tyr Phe Gln Gly 
1               5                   10                  15      


Ser Ser Gly Glu Asp Cys Asn Glu Leu Pro Pro Arg Arg Asn Thr Glu 
            20                  25                  30          


Ile Leu Thr Gly Ser Trp Ser Asp Gln Thr Tyr Pro Glu Gly Thr Gln 
        35                  40                  45              


Ala Ile Tyr Lys Cys Arg Pro Gly Tyr Arg Ser Leu Gly Asn Ile Ile 
    50                  55                  60                  


Met Val Cys Arg Lys Gly Glu Trp Val Ala Leu Asn Pro Leu Arg Lys 
65                  70                  75                  80  


Cys Gln Lys Arg Pro Cys Gly His Pro Gly Asp Thr Pro Phe Gly Thr 
                85                  90                  95      


Phe Thr Leu Thr Gly Gly Asn Val Phe Glu Tyr Gly Val Lys Ala Val 
            100                 105                 110         


Tyr Thr Cys Asn Glu Gly Tyr Gln Leu Leu Gly Glu Ile Asn Tyr Arg 
        115                 120                 125             


Glu Cys Asp Thr Asp Gly Trp Thr Asn Asp Ile Pro Ile Cys Glu Val 
    130                 135                 140                 


Val Lys Cys Leu Pro Val Thr Ala Pro Glu Asn Gly Lys Ile Val Ser 
145                 150                 155                 160 


Ser Ala Met Glu Pro Asp Arg Glu Tyr His Phe Gly Gln Ala Val Arg 
                165                 170                 175     


Phe Val Cys Asn Ser Gly Tyr Lys Ile Glu Gly Asp Glu Glu Met His 
            180                 185                 190         


Cys Ser Asp Asp Gly Phe Trp Ser Lys Glu Lys Pro Lys Cys Val Glu 
        195                 200                 205             


Ile Ser Cys Lys Ser Pro Asp Val Ile Asn Gly Ser Pro Ile Ser Gln 
    210                 215                 220                 


Lys Ile Ile Tyr Lys Glu Asn Glu Arg Phe Gln Tyr Lys Cys Asn Met 
225                 230                 235                 240 


Gly Tyr Glu Tyr Ser Glu Arg Gly Asp Ala Val Cys Thr Glu Ser Gly 
                245                 250                 255     


Trp Arg Pro Leu Pro Ser Cys Glu Glu Gly Gly Gly Gly Ser Arg Gly 
            260                 265                 270         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Ile Val Gly Gly Lys Arg Ala 
        275                 280                 285             


Gln Leu Gly Asp Leu Pro Trp Gln Val Ala Ile Lys Asp Ala Ser Gly 
    290                 295                 300                 


Ile Thr Cys Gly Gly Ile Tyr Ile Gly Gly Cys Trp Ile Leu Thr Ala 
305                 310                 315                 320 


Ala His Cys Leu Arg Ala Ser Lys Thr His Arg Tyr Gln Ile Trp Thr 
                325                 330                 335     


Thr Val Val Asp Trp Ile His Pro Asp Leu Lys Arg Ile Val Ile Glu 
            340                 345                 350         


Tyr Val Asp Arg Ile Ile Phe His Glu Asn Tyr Asn Ala Gly Thr Tyr 
        355                 360                 365             


Gln Asn Asp Ile Ala Leu Ile Glu Met Lys Lys Asp Gly Asn Lys Lys 
    370                 375                 380                 


Asp Cys Glu Leu Pro Arg Ser Ile Pro Ala Ala Val Pro Trp Ser Pro 
385                 390                 395                 400 


Tyr Leu Phe Gln Pro Asn Asp Thr Cys Ile Val Ser Gly Trp Gly Arg 
                405                 410                 415     


Glu Lys Asp Asn Glu Arg Val Phe Ser Leu Gln Trp Gly Glu Val Lys 
            420                 425                 430         


Leu Ile Ser Asn Cys Ser Lys Phe Tyr Gly Asn Arg Phe Tyr Glu Lys 
        435                 440                 445             


Glu Met Glu Cys Ala Gly Thr Tyr Asp Gly Ser Ile Asp Ala Cys Lys 
    450                 455                 460                 


Gly Asp Ser Gly Gly Pro Leu Val Cys Met Asp Ala Asn Asn Val Thr 
465                 470                 475                 480 


Tyr Val Trp Gly Val Val Ser Trp Gly Glu Asn Cys Gly Lys Pro Glu 
                485                 490                 495     


Phe Pro Gly Val Tyr Thr Lys Val Ala Asn Tyr Phe Asp Trp Ile Ser 
            500                 505                 510         


Tyr His Val Gly Arg Pro Phe Ile Ser Gln Tyr Asn Val 
        515                 520                 525 


<210>  36

<400>  36
000

<210>  37
<211>  506
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  non-glycosylated chimeric FH-FI protein amino acid sequence 
       (without signal peptide)

<400>  37

Glu Asp Cys Asn Glu Leu Pro Pro Arg Arg Asn Thr Glu Ile Leu Thr 
1               5                   10                  15      


Gly Ser Trp Ser Asp Gln Thr Tyr Pro Glu Gly Thr Gln Ala Ile Tyr 
            20                  25                  30          


Lys Cys Arg Pro Gly Tyr Arg Ser Leu Gly Asn Ile Ile Met Val Cys 
        35                  40                  45              


Arg Lys Gly Glu Trp Val Ala Leu Asn Pro Leu Arg Lys Cys Gln Lys 
    50                  55                  60                  


Arg Pro Cys Gly His Pro Gly Asp Thr Pro Phe Gly Thr Phe Thr Leu 
65                  70                  75                  80  


Thr Gly Gly Asn Val Phe Glu Tyr Gly Val Lys Ala Val Tyr Thr Cys 
                85                  90                  95      


Asn Glu Gly Tyr Gln Leu Leu Gly Glu Ile Asn Tyr Arg Glu Cys Asp 
            100                 105                 110         


Thr Asp Gly Trp Thr Asn Asp Ile Pro Ile Cys Glu Val Val Lys Cys 
        115                 120                 125             


Leu Pro Val Thr Ala Pro Glu Asn Gly Lys Ile Val Ser Ser Ala Met 
    130                 135                 140                 


Glu Pro Asp Arg Glu Tyr His Phe Gly Gln Ala Val Arg Phe Val Cys 
145                 150                 155                 160 


Asn Ser Gly Tyr Lys Ile Glu Gly Asp Glu Glu Met His Cys Ser Asp 
                165                 170                 175     


Asp Gly Phe Trp Ser Lys Glu Lys Pro Lys Cys Val Glu Ile Ser Cys 
            180                 185                 190         


Lys Ser Pro Asp Val Ile Asn Gly Ser Pro Ile Ser Gln Lys Ile Ile 
        195                 200                 205             


Tyr Lys Glu Asn Glu Arg Phe Gln Tyr Lys Cys Asn Met Gly Tyr Glu 
    210                 215                 220                 


Tyr Ser Glu Arg Gly Asp Ala Val Cys Thr Glu Ser Gly Trp Arg Pro 
225                 230                 235                 240 


Leu Pro Ser Cys Glu Glu Gly Gly Gly Gly Ser Arg Gly Gly Gly Gly 
                245                 250                 255     


Ser Gly Gly Gly Gly Ser Ile Val Gly Gly Lys Arg Ala Gln Leu Gly 
            260                 265                 270         


Asp Leu Pro Trp Gln Val Ala Ile Lys Asp Ala Ser Gly Ile Thr Cys 
        275                 280                 285             


Gly Gly Ile Tyr Ile Gly Gly Cys Trp Ile Leu Thr Ala Ala His Cys 
    290                 295                 300                 


Leu Arg Ala Ser Lys Thr His Arg Tyr Gln Ile Trp Thr Thr Val Val 
305                 310                 315                 320 


Asp Trp Ile His Pro Asp Leu Lys Arg Ile Val Ile Glu Tyr Val Asp 
                325                 330                 335     


Arg Ile Ile Phe His Glu Asn Tyr Asn Ala Gly Thr Tyr Gln Asn Asp 
            340                 345                 350         


Ile Ala Leu Ile Glu Met Lys Lys Asp Gly Asn Lys Lys Asp Cys Glu 
        355                 360                 365             


Leu Pro Arg Ser Ile Pro Ala Ala Val Pro Trp Ser Pro Tyr Leu Phe 
    370                 375                 380                 


Gln Pro Gln Asp Thr Cys Ile Val Ser Gly Trp Gly Arg Glu Lys Asp 
385                 390                 395                 400 


Asn Glu Arg Val Phe Ser Leu Gln Trp Gly Glu Val Lys Leu Ile Ser 
                405                 410                 415     


Gln Cys Ser Lys Phe Tyr Gly Asn Arg Phe Tyr Glu Lys Glu Met Glu 
            420                 425                 430         


Cys Ala Gly Thr Tyr Asp Gly Ser Ile Asp Ala Cys Lys Gly Asp Ser 
        435                 440                 445             


Gly Gly Pro Leu Val Cys Met Asp Ala Asn Gln Val Thr Tyr Val Trp 
    450                 455                 460                 


Gly Val Val Ser Trp Gly Glu Asn Cys Gly Lys Pro Glu Phe Pro Gly 
465                 470                 475                 480 


Val Tyr Thr Lys Val Ala Asn Tyr Phe Asp Trp Ile Ser Tyr His Val 
                485                 490                 495     


Gly Arg Pro Phe Ile Ser Gln Tyr Asn Val 
            500                 505     


<210>  38
<211>  449
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Complement Factor H isoform FHL-1 (UniProt: P08603-2)

<400>  38

Met Arg Leu Leu Ala Lys Ile Ile Cys Leu Met Leu Trp Ala Ile Cys 
1               5                   10                  15      


Val Ala Glu Asp Cys Asn Glu Leu Pro Pro Arg Arg Asn Thr Glu Ile 
            20                  25                  30          


Leu Thr Gly Ser Trp Ser Asp Gln Thr Tyr Pro Glu Gly Thr Gln Ala 
        35                  40                  45              


Ile Tyr Lys Cys Arg Pro Gly Tyr Arg Ser Leu Gly Asn Val Ile Met 
    50                  55                  60                  


Val Cys Arg Lys Gly Glu Trp Val Ala Leu Asn Pro Leu Arg Lys Cys 
65                  70                  75                  80  


Gln Lys Arg Pro Cys Gly His Pro Gly Asp Thr Pro Phe Gly Thr Phe 
                85                  90                  95      


Thr Leu Thr Gly Gly Asn Val Phe Glu Tyr Gly Val Lys Ala Val Tyr 
            100                 105                 110         


Thr Cys Asn Glu Gly Tyr Gln Leu Leu Gly Glu Ile Asn Tyr Arg Glu 
        115                 120                 125             


Cys Asp Thr Asp Gly Trp Thr Asn Asp Ile Pro Ile Cys Glu Val Val 
    130                 135                 140                 


Lys Cys Leu Pro Val Thr Ala Pro Glu Asn Gly Lys Ile Val Ser Ser 
145                 150                 155                 160 


Ala Met Glu Pro Asp Arg Glu Tyr His Phe Gly Gln Ala Val Arg Phe 
                165                 170                 175     


Val Cys Asn Ser Gly Tyr Lys Ile Glu Gly Asp Glu Glu Met His Cys 
            180                 185                 190         


Ser Asp Asp Gly Phe Trp Ser Lys Glu Lys Pro Lys Cys Val Glu Ile 
        195                 200                 205             


Ser Cys Lys Ser Pro Asp Val Ile Asn Gly Ser Pro Ile Ser Gln Lys 
    210                 215                 220                 


Ile Ile Tyr Lys Glu Asn Glu Arg Phe Gln Tyr Lys Cys Asn Met Gly 
225                 230                 235                 240 


Tyr Glu Tyr Ser Glu Arg Gly Asp Ala Val Cys Thr Glu Ser Gly Trp 
                245                 250                 255     


Arg Pro Leu Pro Ser Cys Glu Glu Lys Ser Cys Asp Asn Pro Tyr Ile 
            260                 265                 270         


Pro Asn Gly Asp Tyr Ser Pro Leu Arg Ile Lys His Arg Thr Gly Asp 
        275                 280                 285             


Glu Ile Thr Tyr Gln Cys Arg Asn Gly Phe Tyr Pro Ala Thr Arg Gly 
    290                 295                 300                 


Asn Thr Ala Lys Cys Thr Ser Thr Gly Trp Ile Pro Ala Pro Arg Cys 
305                 310                 315                 320 


Thr Leu Lys Pro Cys Asp Tyr Pro Asp Ile Lys His Gly Gly Leu Tyr 
                325                 330                 335     


His Glu Asn Met Arg Arg Pro Tyr Phe Pro Val Ala Val Gly Lys Tyr 
            340                 345                 350         


Tyr Ser Tyr Tyr Cys Asp Glu His Phe Glu Thr Pro Ser Gly Ser Tyr 
        355                 360                 365             


Trp Asp His Ile His Cys Thr Gln Asp Gly Trp Ser Pro Ala Val Pro 
    370                 375                 380                 


Cys Leu Arg Lys Cys Tyr Phe Pro Tyr Leu Glu Asn Gly Tyr Asn Gln 
385                 390                 395                 400 


Asn Tyr Gly Arg Lys Phe Val Gln Gly Lys Ser Ile Asp Val Ala Cys 
                405                 410                 415     


His Pro Gly Tyr Ala Leu Pro Lys Ala Gln Thr Thr Val Thr Cys Met 
            420                 425                 430         


Glu Asn Gly Trp Ser Pro Thr Pro Arg Cys Ile Arg Val Ser Phe Thr 
        435                 440                 445             


Leu 
    


<210>  39
<211>  184
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Complement Factor H CCPs 6-8 (UniProt: P08603 residues 324 to 
       507)

<400>  39

Pro Cys Asp Tyr Pro Asp Ile Lys His Gly Gly Leu Tyr His Glu Asn 
1               5                   10                  15      


Met Arg Arg Pro Tyr Phe Pro Val Ala Val Gly Lys Tyr Tyr Ser Tyr 
            20                  25                  30          


Tyr Cys Asp Glu His Phe Glu Thr Pro Ser Gly Ser Tyr Trp Asp His 
        35                  40                  45              


Ile His Cys Thr Gln Asp Gly Trp Ser Pro Ala Val Pro Cys Leu Arg 
    50                  55                  60                  


Lys Cys Tyr Phe Pro Tyr Leu Glu Asn Gly Tyr Asn Gln Asn Tyr Gly 
65                  70                  75                  80  


Arg Lys Phe Val Gln Gly Lys Ser Ile Asp Val Ala Cys His Pro Gly 
                85                  90                  95      


Tyr Ala Leu Pro Lys Ala Gln Thr Thr Val Thr Cys Met Glu Asn Gly 
            100                 105                 110         


Trp Ser Pro Thr Pro Arg Cys Ile Arg Val Lys Thr Cys Ser Lys Ser 
        115                 120                 125             


Ser Ile Asp Ile Glu Asn Gly Phe Ile Ser Glu Ser Gln Tyr Thr Tyr 
    130                 135                 140                 


Ala Leu Lys Glu Lys Ala Lys Tyr Gln Cys Lys Leu Gly Tyr Val Thr 
145                 150                 155                 160 


Ala Asp Gly Glu Thr Ser Gly Ser Ile Thr Cys Gly Lys Asp Gly Trp 
                165                 170                 175     


Ser Ala Gln Pro Thr Cys Ile Lys 
            180                 


<210>  40
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Complement Factor H CCPs 19-20 (UniProt: P08603 residues 1107 to 
       1230)

<400>  40

Gly Lys Cys Gly Pro Pro Pro Pro Ile Asp Asn Gly Asp Ile Thr Ser 
1               5                   10                  15      


Phe Pro Leu Ser Val Tyr Ala Pro Ala Ser Ser Val Glu Tyr Gln Cys 
            20                  25                  30          


Gln Asn Leu Tyr Gln Leu Glu Gly Asn Lys Arg Ile Thr Cys Arg Asn 
        35                  40                  45              


Gly Gln Trp Ser Glu Pro Pro Lys Cys Leu His Pro Cys Val Ile Ser 
    50                  55                  60                  


Arg Glu Ile Met Glu Asn Tyr Asn Ile Ala Leu Arg Trp Thr Ala Lys 
65                  70                  75                  80  


Gln Lys Leu Tyr Ser Arg Thr Gly Glu Ser Val Glu Phe Val Cys Lys 
                85                  90                  95      


Arg Gly Tyr Arg Leu Ser Ser Arg Ser His Thr Leu Arg Thr Thr Cys 
            100                 105                 110         


Trp Asp Gly Lys Leu Glu Tyr Pro Thr Cys Ala Lys 
        115                 120                 


<210>  41
<211>  185
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Complement Factor H isoform FHL-1 (UniProt: P08603-2 residues 265
       to 449)

<400>  41

Lys Ser Cys Asp Asn Pro Tyr Ile Pro Asn Gly Asp Tyr Ser Pro Leu 
1               5                   10                  15      


Arg Ile Lys His Arg Thr Gly Asp Glu Ile Thr Tyr Gln Cys Arg Asn 
            20                  25                  30          


Gly Phe Tyr Pro Ala Thr Arg Gly Asn Thr Ala Lys Cys Thr Ser Thr 
        35                  40                  45              


Gly Trp Ile Pro Ala Pro Arg Cys Thr Leu Lys Pro Cys Asp Tyr Pro 
    50                  55                  60                  


Asp Ile Lys His Gly Gly Leu Tyr His Glu Asn Met Arg Arg Pro Tyr 
65                  70                  75                  80  


Phe Pro Val Ala Val Gly Lys Tyr Tyr Ser Tyr Tyr Cys Asp Glu His 
                85                  90                  95      


Phe Glu Thr Pro Ser Gly Ser Tyr Trp Asp His Ile His Cys Thr Gln 
            100                 105                 110         


Asp Gly Trp Ser Pro Ala Val Pro Cys Leu Arg Lys Cys Tyr Phe Pro 
        115                 120                 125             


Tyr Leu Glu Asn Gly Tyr Asn Gln Asn Tyr Gly Arg Lys Phe Val Gln 
    130                 135                 140                 


Gly Lys Ser Ile Asp Val Ala Cys His Pro Gly Tyr Ala Leu Pro Lys 
145                 150                 155                 160 


Ala Gln Thr Thr Val Thr Cys Met Glu Asn Gly Trp Ser Pro Thr Pro 
                165                 170                 175     


Arg Cys Ile Arg Val Ser Phe Thr Leu 
            180                 185 


<210>  42
<211>  1719
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  His-tagged glycosylated chimeric FH-FI coding sequence protein

<400>  42
tatagggaga cccaagctgg ctagcgttta aacttaagct tgccaccatg agactgctgg       60

ccaagatcat ctgcctgatg ctgtgggcca tctgcgtggc ccaccaccat caccatcacg      120

gcagcagcga gaacctgtac ttccaaggca gctccggcga ggactgcaat gagctgcctc      180

ctagacggaa caccgagatc ctgacaggct cttggagcga ccagacatac cctgagggaa      240

cccaggccat ctacaagtgc agacccggct acagaagcct gggcaacatc atcatggtct      300

gccggaaagg cgagtgggtc gccctgaatc ctctgcggaa gtgccagaaa agaccctgcg      360

gacaccctgg cgatacccct ttcggaacct ttacactgac cggcggcaac gtgttcgagt      420

acggcgtgaa agccgtgtac acctgtaacg agggctacca gctgctgggc gagatcaact      480

acagagagtg cgataccgac ggctggacca acgacatccc tatctgcgag gtggtcaagt      540

gcctgcctgt gacagcccct gagaacggca agattgtgtc cagcgccatg gaacccgaca      600

gagagtacca ctttggccag gccgtcagat tcgtgtgcaa cagcggctac aagatcgagg      660

gcgacgagga aatgcactgc agcgacgatg gcttctggtc caaagaaaag cctaagtgcg      720

tggaaatcag ctgcaagagc cccgacgtga tcaacggcag ccctatcagc cagaagatta      780

tctacaaaga gaacgagcgg ttccagtaca agtgtaacat gggctacgag tacagcgaga      840

ggggcgacgc cgtgtgtaca gaatctggat ggcgacctct gcctagctgc gaagaaggtg      900

gcggaggatc tagaggcgga ggcggaagtg gcggtggtgg atctatcgtt ggaggcaaga      960

gagcacagct gggcgacctt ccatggcagg ttgccatcaa ggatgccagc ggcatcacat     1020

gcggcggcat ctatatcggc ggctgctgga ttctgaccgc cgctcattgt ctgagagcca     1080

gcaagaccca ccggtatcag atctggacca ccgtggtgga ctggattcac cccgacctga     1140

agcggatcgt gatcgagtat gtggaccgga tcatcttcca cgagaactac aacgccggca     1200

cctaccagaa cgatatcgcc ctgatcgaga tgaagaagga cggcaacaag aaggactgcg     1260

agctgcccag atctatccct gctgctgttc cttggagccc ctacctgttc cagcctaacg     1320

atacctgcat cgtgtccggc tggggcagag agaaggacaa cgaaagggtg ttcagcctgc     1380

agtggggcga agtgaagctg atctccaact gcagcaagtt ctacggcaac cggttctacg     1440

agaaagaaat ggaatgcgcc ggcacatacg acggctccat cgatgcctgt aaaggcgatt     1500

ctggcggccc tctcgtgtgc atggatgcca acaatgtgac ctacgtgtgg ggcgtcgtgt     1560

cctggggaga gaattgtggc aagcctgagt tccccggcgt gtacacaaag gtggccaact     1620

acttcgactg gatcagctac cacgtgggca gacccttcat cagccagtac aacgttgcgg     1680

ccgctcgagt ctagagggcc cgtttaaacc cgctgatca                            1719


<210>  43
<211>  1718
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  His-tagged non-glycosylated chimeric FH-FI protein coding 
       sequence

<400>  43
atagggagac ccaagctggc tagcgtttaa acttaagctt gccaccatga gactgctggc       60

caagatcatc tgcctgatgc tgtgggccat ctgcgtggcc caccaccatc accatcacgg      120

cagcagcgag aacctgtact tccaaggcag ctccggcgag gactgcaatg agctgcctcc      180

tagacggaac accgagatcc tgacaggctc ttggagcgac cagacatacc ctgagggaac      240

ccaggccatc tacaagtgca gacccggcta cagaagcctg ggcaacatca tcatggtctg      300

ccggaaaggc gagtgggtcg ccctgaatcc tctgcggaag tgccagaaaa gaccctgcgg      360

acaccctggc gatacccctt tcggaacctt tacactgacc ggcggcaacg tgttcgagta      420

cggcgtgaaa gccgtgtaca cctgtaacga gggctaccag ctgctgggcg agatcaacta      480

cagagagtgc gataccgacg gctggaccaa cgacatccct atctgcgagg tggtcaagtg      540

cctgcctgtg acagcccctg agaacggcaa gattgtgtcc agcgccatgg aacccgacag      600

agagtaccac tttggccagg ccgtcagatt cgtgtgcaac agcggctaca agatcgaggg      660

cgacgaggaa atgcactgca gcgacgatgg cttctggtcc aaagaaaagc ctaagtgcgt      720

ggaaatcagc tgcaagagcc ccgacgtgat caacggcagc cctatcagcc agaagattat      780

ctacaaagag aacgagcggt tccagtacaa gtgtaacatg ggctacgagt acagcgagag      840

gggcgacgcc gtgtgtacag aatctggatg gcgacctctg cctagctgcg aagaaggtgg      900

cggaggatct agaggcggag gcggaagtgg cggtggtgga tctatcgttg gaggcaagag      960

agcacagctg ggcgaccttc catggcaggt tgccatcaag gatgccagcg gcatcacatg     1020

cggcggcatc tatatcggcg gctgctggat tctgaccgcc gctcattgtc tgagagccag     1080

caagacccac cggtatcaga tctggaccac cgtggtggac tggattcacc ccgacctgaa     1140

gcggatcgtg atcgagtatg tggaccggat catcttccac gagaactaca acgccggcac     1200

ctaccagaac gatatcgccc tgatcgagat gaagaaggac ggcaacaaga aggactgcga     1260

gctgcccaga tctatccctg ctgctgttcc ttggagcccc tacctgttcc agcctcaaga     1320

tacctgcatc gtgtccggct ggggcagaga gaaggacaac gaaagggtgt tcagcctgca     1380

gtggggcgaa gtgaagctga tctcccagtg cagcaagttc tacggcaacc ggttctacga     1440

gaaagaaatg gaatgcgccg gcacatacga cggctccatc gatgcctgta aaggcgattc     1500

tggcggccct ctcgtgtgca tggatgccaa tcaagtgacc tacgtgtggg gcgtcgtgtc     1560

ctggggagag aattgtggca agcctgagtt ccccggcgtg tacacaaagg tggccaacta     1620

cttcgactgg atcagctacc acgtgggcag acccttcatc agccagtaca acgttgcggc     1680

cgctcgagtc tagagggccc gtttaaaccc gctgatca                             1718


<210>  44
<211>  1665
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  non-glycosylated chimeric FH-FI protein coding sequence

<400>  44
tatagggaga cccaagctgg ctagcgttta aacttaagct tgccaccatg agactgctgg       60

ccaagatcat ctgcctgatg ctgtgggcca tctgcgtggc cgaggattgc aatgagctgc      120

ctcctcggag aaacaccgag atcctgacag gctcttggag cgaccagaca taccctgagg      180

gaacccaggc catctacaag tgcagacccg gctacagaag cctgggcaac atcatcatgg      240

tctgccggaa aggcgagtgg gtcgccctga atcctctgcg gaagtgccag aaaagaccct      300

gcggacaccc tggcgatacc cctttcggaa cctttacact gaccggcggc aacgtgttcg      360

agtacggcgt gaaagccgtg tacacctgta acgagggcta ccagctgctg ggcgagatca      420

actacagaga gtgcgatacc gacggctgga ccaacgacat ccctatctgc gaggtggtca      480

agtgcctgcc tgtgacagcc cctgagaacg gcaagattgt gtccagcgcc atggaacccg      540

acagagagta ccactttggc caggccgtca gattcgtgtg caacagcggc tacaagatcg      600

agggcgacga ggaaatgcac tgcagcgacg atggcttctg gtccaaagaa aagcctaagt      660

gcgtggaaat cagctgcaag agccccgacg tgatcaacgg cagccctatc agccagaaga      720

ttatctacaa agagaacgag cggttccagt acaagtgtaa catgggctac gagtacagcg      780

agaggggcga cgccgtgtgt acagaatctg gatggcgacc tctgcctagc tgcgaagaag      840

gtggcggagg atctagaggc ggaggcggaa gtggcggtgg tggatctatc gttggaggca      900

agagagcaca gctgggcgac ctgccttggc aggttgccat taaggatgcc agcggcatca      960

cctgtggcgg catctatatc ggcggctgct ggattctgac cgccgctcat tgtctgagag     1020

ccagcaagac ccaccggtat cagatctgga ccaccgtggt ggactggatt caccccgacc     1080

tgaagcggat cgtgatcgag tatgtggacc ggatcatctt ccacgagaac tacaacgccg     1140

gcacctacca gaacgatatc gccctgatcg agatgaagaa ggacggcaac aagaaggact     1200

gcgagctgcc cagatctatc cctgctgctg ttccttggag cccctacctg ttccagcctc     1260

aagatacctg catcgtgtcc ggctggggca gagagaagga caacgaaagg gtgttcagcc     1320

tgcagtgggg cgaagtgaag ctgatctccc agtgcagcaa gttctacggc aaccggttct     1380

acgagaaaga aatggaatgc gccggcacat acgacggctc catcgatgcc tgtaaaggcg     1440

attctggcgg ccctctcgtg tgcatggatg ccaatcaagt gacctacgtg tggggcgtcg     1500

tgtcctgggg agagaattgt ggcaagcctg agttccccgg cgtgtacaca aaggtggcca     1560

actacttcga ctggatcagc taccacgtgg gcagaccctt catcagccag tacaacgtct     1620

gagcggccgc tcgagtctag agggcccgtt taaacccgct gatca                     1665


<210>  45
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  G4S linker

<400>  45

Gly Gly Gly Gly Ser 
1               5   


<210>  46
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Tryptic peptide

<400>  46

Gly Asp Ala Val Cys Thr Glu Ser Gly Trp Arg Pro Leu Pro Ser Cys 
1               5                   10                  15      


Glu Glu Gly Gly Gly Gly Ser Arg 
            20                  


<210>  47
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Tryptic peptide

<400>  47

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ile Val Gly Gly Lys 
1               5                   10                  15  


<210>  48
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  G4S-K-(G4S)2 linker

<400>  48

Gly Gly Gly Gly Ser Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15      


<210>  49
<211>  506
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glycosylated chimeric FH-FI protein amino acid sequence (without 
       signal peptide)

<400>  49

Glu Asp Cys Asn Glu Leu Pro Pro Arg Arg Asn Thr Glu Ile Leu Thr 
1               5                   10                  15      


Gly Ser Trp Ser Asp Gln Thr Tyr Pro Glu Gly Thr Gln Ala Ile Tyr 
            20                  25                  30          


Lys Cys Arg Pro Gly Tyr Arg Ser Leu Gly Asn Ile Ile Met Val Cys 
        35                  40                  45              


Arg Lys Gly Glu Trp Val Ala Leu Asn Pro Leu Arg Lys Cys Gln Lys 
    50                  55                  60                  


Arg Pro Cys Gly His Pro Gly Asp Thr Pro Phe Gly Thr Phe Thr Leu 
65                  70                  75                  80  


Thr Gly Gly Asn Val Phe Glu Tyr Gly Val Lys Ala Val Tyr Thr Cys 
                85                  90                  95      


Asn Glu Gly Tyr Gln Leu Leu Gly Glu Ile Asn Tyr Arg Glu Cys Asp 
            100                 105                 110         


Thr Asp Gly Trp Thr Asn Asp Ile Pro Ile Cys Glu Val Val Lys Cys 
        115                 120                 125             


Leu Pro Val Thr Ala Pro Glu Asn Gly Lys Ile Val Ser Ser Ala Met 
    130                 135                 140                 


Glu Pro Asp Arg Glu Tyr His Phe Gly Gln Ala Val Arg Phe Val Cys 
145                 150                 155                 160 


Asn Ser Gly Tyr Lys Ile Glu Gly Asp Glu Glu Met His Cys Ser Asp 
                165                 170                 175     


Asp Gly Phe Trp Ser Lys Glu Lys Pro Lys Cys Val Glu Ile Ser Cys 
            180                 185                 190         


Lys Ser Pro Asp Val Ile Asn Gly Ser Pro Ile Ser Gln Lys Ile Ile 
        195                 200                 205             


Tyr Lys Glu Asn Glu Arg Phe Gln Tyr Lys Cys Asn Met Gly Tyr Glu 
    210                 215                 220                 


Tyr Ser Glu Arg Gly Asp Ala Val Cys Thr Glu Ser Gly Trp Arg Pro 
225                 230                 235                 240 


Leu Pro Ser Cys Glu Glu Gly Gly Gly Gly Ser Arg Gly Gly Gly Gly 
                245                 250                 255     


Ser Gly Gly Gly Gly Ser Ile Val Gly Gly Lys Arg Ala Gln Leu Gly 
            260                 265                 270         


Asp Leu Pro Trp Gln Val Ala Ile Lys Asp Ala Ser Gly Ile Thr Cys 
        275                 280                 285             


Gly Gly Ile Tyr Ile Gly Gly Cys Trp Ile Leu Thr Ala Ala His Cys 
    290                 295                 300                 


Leu Arg Ala Ser Lys Thr His Arg Tyr Gln Ile Trp Thr Thr Val Val 
305                 310                 315                 320 


Asp Trp Ile His Pro Asp Leu Lys Arg Ile Val Ile Glu Tyr Val Asp 
                325                 330                 335     


Arg Ile Ile Phe His Glu Asn Tyr Asn Ala Gly Thr Tyr Gln Asn Asp 
            340                 345                 350         


Ile Ala Leu Ile Glu Met Lys Lys Asp Gly Asn Lys Lys Asp Cys Glu 
        355                 360                 365             


Leu Pro Arg Ser Ile Pro Ala Ala Val Pro Trp Ser Pro Tyr Leu Phe 
    370                 375                 380                 


Gln Pro Asn Asp Thr Cys Ile Val Ser Gly Trp Gly Arg Glu Lys Asp 
385                 390                 395                 400 


Asn Glu Arg Val Phe Ser Leu Gln Trp Gly Glu Val Lys Leu Ile Ser 
                405                 410                 415     


Asn Cys Ser Lys Phe Tyr Gly Asn Arg Phe Tyr Glu Lys Glu Met Glu 
            420                 425                 430         


Cys Ala Gly Thr Tyr Asp Gly Ser Ile Asp Ala Cys Lys Gly Asp Ser 
        435                 440                 445             


Gly Gly Pro Leu Val Cys Met Asp Ala Asn Asn Val Thr Tyr Val Trp 
    450                 455                 460                 


Gly Val Val Ser Trp Gly Glu Asn Cys Gly Lys Pro Glu Phe Pro Gly 
465                 470                 475                 480 


Val Tyr Thr Lys Val Ala Asn Tyr Phe Asp Trp Ile Ser Tyr His Val 
                485                 490                 495     


Gly Arg Pro Phe Ile Ser Gln Tyr Asn Val 
            500                 505     


<210>  50
<211>  502
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  His-tagged glycosylated chimeric CR1a-FI protein amino acid 
       sequence

<400>  50

Met Arg Leu Leu Ala Lys Ile Ile Cys Leu Met Leu Trp Ala Ile Cys 
1               5                   10                  15      


Val Ala His His His His His His Gly Ser Ser Glu Asn Leu Tyr Phe 
            20                  25                  30          


Gln Gly Ser Ser Gly Gly His Cys Gln Ala Pro Asp His Phe Leu Phe 
        35                  40                  45              


Ala Lys Leu Lys Thr Gln Thr Asn Ala Ser Asp Phe Pro Ile Gly Thr 
    50                  55                  60                  


Ser Leu Lys Tyr Glu Cys Arg Pro Glu Tyr Tyr Gly Arg Pro Phe Ser 
65                  70                  75                  80  


Ile Thr Cys Leu Asp Asn Leu Val Trp Ser Ser Pro Lys Asp Val Cys 
                85                  90                  95      


Lys Arg Lys Ser Cys Lys Thr Pro Pro Asp Pro Val Asn Gly Met Val 
            100                 105                 110         


His Val Ile Thr Asp Ile Gln Val Gly Ser Arg Ile Asn Tyr Ser Cys 
        115                 120                 125             


Thr Thr Gly His Arg Leu Ile Gly His Ser Ser Ala Glu Cys Ile Leu 
    130                 135                 140                 


Ser Gly Asn Ala Ala His Trp Ser Thr Lys Pro Pro Ile Cys Gln Arg 
145                 150                 155                 160 


Ile Pro Cys Gly Leu Pro Pro Thr Ile Ala Asn Gly Asp Phe Ile Ser 
                165                 170                 175     


Thr Asn Arg Glu Asn Phe His Tyr Gly Ser Val Val Thr Tyr Arg Cys 
            180                 185                 190         


Asn Pro Gly Ser Gly Gly Arg Lys Val Phe Glu Leu Val Gly Glu Pro 
        195                 200                 205             


Ser Ile Tyr Cys Thr Ser Asn Asp Asp Gln Val Gly Ile Trp Ser Gly 
    210                 215                 220                 


Pro Ala Pro Gln Cys Ile Ile Pro Asn Lys Ala Thr Pro Pro Asn Val 
225                 230                 235                 240 


Glu Asn Gly Gly Gly Gly Ser Arg Gly Gly Gly Gly Ser Gly Gly Gly 
                245                 250                 255     


Gly Ser Ile Val Gly Gly Lys Arg Ala Gln Leu Gly Asp Leu Pro Trp 
            260                 265                 270         


Gln Val Ala Ile Lys Asp Ala Ser Gly Ile Thr Cys Gly Gly Ile Tyr 
        275                 280                 285             


Ile Gly Gly Cys Trp Ile Leu Thr Ala Ala His Cys Leu Arg Ala Ser 
    290                 295                 300                 


Lys Thr His Arg Tyr Gln Ile Trp Thr Thr Val Val Asp Trp Ile His 
305                 310                 315                 320 


Pro Asp Leu Lys Arg Ile Val Ile Glu Tyr Val Asp Arg Ile Ile Phe 
                325                 330                 335     


His Glu Asn Tyr Asn Ala Gly Thr Tyr Gln Asn Asp Ile Ala Leu Ile 
            340                 345                 350         


Glu Met Lys Lys Asp Gly Asn Lys Lys Asp Cys Glu Leu Pro Arg Ser 
        355                 360                 365             


Ile Pro Ala Ala Val Pro Trp Ser Pro Tyr Leu Phe Gln Pro Asn Asp 
    370                 375                 380                 


Thr Cys Ile Val Ser Gly Trp Gly Arg Glu Lys Asp Asn Glu Arg Val 
385                 390                 395                 400 


Phe Ser Leu Gln Trp Gly Glu Val Lys Leu Ile Ser Asn Cys Ser Lys 
                405                 410                 415     


Phe Tyr Gly Asn Arg Phe Tyr Glu Lys Glu Met Glu Cys Ala Gly Thr 
            420                 425                 430         


Tyr Asp Gly Ser Ile Asp Ala Cys Lys Gly Asp Ser Gly Gly Pro Leu 
        435                 440                 445             


Val Cys Met Asp Ala Asn Asn Val Thr Tyr Val Trp Gly Val Val Ser 
    450                 455                 460                 


Trp Gly Glu Asn Cys Gly Lys Pro Glu Phe Pro Gly Val Tyr Thr Lys 
465                 470                 475                 480 


Val Ala Asn Tyr Phe Asp Trp Ile Ser Tyr His Val Gly Arg Pro Phe 
                485                 490                 495     


Ile Ser Gln Tyr Asn Val 
            500         


<210>  51
<211>  502
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  His-tagged glycosylated chimeric CR1b-FI protein amino acid 
       sequence

<400>  51

Met Arg Leu Leu Ala Lys Ile Ile Cys Leu Met Leu Trp Ala Ile Cys 
1               5                   10                  15      


Val Ala His His His His His His Gly Ser Ser Glu Asn Leu Tyr Phe 
            20                  25                  30          


Gln Gly Ser Ser Gly Gly His Cys Gln Ala Pro Asp His Phe Leu Phe 
        35                  40                  45              


Ala Lys Leu Lys Thr Gln Thr Asn Ala Ser Asp Phe Pro Ile Gly Thr 
    50                  55                  60                  


Ser Leu Lys Tyr Glu Cys Arg Pro Glu Tyr Tyr Gly Arg Pro Phe Ser 
65                  70                  75                  80  


Ile Thr Cys Leu Asp Asn Leu Val Trp Ser Ser Pro Lys Asp Val Cys 
                85                  90                  95      


Lys Arg Lys Ser Cys Lys Thr Pro Pro Asp Pro Val Asn Gly Met Val 
            100                 105                 110         


His Val Ile Thr Asp Ile Gln Val Gly Ser Arg Ile Asn Tyr Ser Cys 
        115                 120                 125             


Thr Thr Gly His Arg Leu Ile Gly His Ser Ser Ala Glu Cys Ile Leu 
    130                 135                 140                 


Ser Gly Asn Thr Ala His Trp Ser Thr Lys Pro Pro Ile Cys Gln Arg 
145                 150                 155                 160 


Ile Pro Cys Gly Leu Pro Pro Thr Ile Ala Asn Gly Asp Phe Ile Ser 
                165                 170                 175     


Thr Asn Arg Glu Asn Phe His Tyr Gly Ser Val Val Thr Tyr Arg Cys 
            180                 185                 190         


Asn Leu Gly Ser Arg Gly Arg Lys Val Phe Glu Leu Val Gly Glu Pro 
        195                 200                 205             


Ser Ile Tyr Cys Thr Ser Asn Asp Asp Gln Val Gly Ile Trp Ser Gly 
    210                 215                 220                 


Pro Ala Pro Gln Cys Ile Ile Pro Asn Lys Ala Thr Pro Pro Asn Val 
225                 230                 235                 240 


Glu Asn Gly Gly Gly Gly Ser Arg Gly Gly Gly Gly Ser Gly Gly Gly 
                245                 250                 255     


Gly Ser Ile Val Gly Gly Lys Arg Ala Gln Leu Gly Asp Leu Pro Trp 
            260                 265                 270         


Gln Val Ala Ile Lys Asp Ala Ser Gly Ile Thr Cys Gly Gly Ile Tyr 
        275                 280                 285             


Ile Gly Gly Cys Trp Ile Leu Thr Ala Ala His Cys Leu Arg Ala Ser 
    290                 295                 300                 


Lys Thr His Arg Tyr Gln Ile Trp Thr Thr Val Val Asp Trp Ile His 
305                 310                 315                 320 


Pro Asp Leu Lys Arg Ile Val Ile Glu Tyr Val Asp Arg Ile Ile Phe 
                325                 330                 335     


His Glu Asn Tyr Asn Ala Gly Thr Tyr Gln Asn Asp Ile Ala Leu Ile 
            340                 345                 350         


Glu Met Lys Lys Asp Gly Asn Lys Lys Asp Cys Glu Leu Pro Arg Ser 
        355                 360                 365             


Ile Pro Ala Ala Val Pro Trp Ser Pro Tyr Leu Phe Gln Pro Asn Asp 
    370                 375                 380                 


Thr Cys Ile Val Ser Gly Trp Gly Arg Glu Lys Asp Asn Glu Arg Val 
385                 390                 395                 400 


Phe Ser Leu Gln Trp Gly Glu Val Lys Leu Ile Ser Asn Cys Ser Lys 
                405                 410                 415     


Phe Tyr Gly Asn Arg Phe Tyr Glu Lys Glu Met Glu Cys Ala Gly Thr 
            420                 425                 430         


Tyr Asp Gly Ser Ile Asp Ala Cys Lys Gly Asp Ser Gly Gly Pro Leu 
        435                 440                 445             


Val Cys Met Asp Ala Asn Asn Val Thr Tyr Val Trp Gly Val Val Ser 
    450                 455                 460                 


Trp Gly Glu Asn Cys Gly Lys Pro Glu Phe Pro Gly Val Tyr Thr Lys 
465                 470                 475                 480 


Val Ala Asn Tyr Phe Asp Trp Ile Ser Tyr His Val Gly Arg Pro Phe 
                485                 490                 495     


Ile Ser Gln Tyr Asn Val 
            500         


<210>  52
<211>  502
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  His-tagged non-glycosylated chimeric CR1a-FI protein amino acid 
       sequence

<400>  52

Met Arg Leu Leu Ala Lys Ile Ile Cys Leu Met Leu Trp Ala Ile Cys 
1               5                   10                  15      


Val Ala His His His His His His Gly Ser Ser Glu Asn Leu Tyr Phe 
            20                  25                  30          


Gln Gly Ser Ser Gly Gly His Cys Gln Ala Pro Asp His Phe Leu Phe 
        35                  40                  45              


Ala Lys Leu Lys Thr Gln Thr Gln Ala Ser Asp Phe Pro Ile Gly Thr 
    50                  55                  60                  


Ser Leu Lys Tyr Glu Cys Arg Pro Glu Tyr Tyr Gly Arg Pro Phe Ser 
65                  70                  75                  80  


Ile Thr Cys Leu Asp Asn Leu Val Trp Ser Ser Pro Lys Asp Val Cys 
                85                  90                  95      


Lys Arg Lys Ser Cys Lys Thr Pro Pro Asp Pro Val Asn Gly Met Val 
            100                 105                 110         


His Val Ile Thr Asp Ile Gln Val Gly Ser Arg Ile Gln Tyr Ser Cys 
        115                 120                 125             


Thr Thr Gly His Arg Leu Ile Gly His Ser Ser Ala Glu Cys Ile Leu 
    130                 135                 140                 


Ser Gly Asn Ala Ala His Trp Ser Thr Lys Pro Pro Ile Cys Gln Arg 
145                 150                 155                 160 


Ile Pro Cys Gly Leu Pro Pro Thr Ile Ala Asn Gly Asp Phe Ile Ser 
                165                 170                 175     


Thr Asn Arg Glu Asn Phe His Tyr Gly Ser Val Val Thr Tyr Arg Cys 
            180                 185                 190         


Asn Pro Gly Ser Gly Gly Arg Lys Val Phe Glu Leu Val Gly Glu Pro 
        195                 200                 205             


Ser Ile Tyr Cys Thr Ser Asn Asp Asp Gln Val Gly Ile Trp Ser Gly 
    210                 215                 220                 


Pro Ala Pro Gln Cys Ile Ile Pro Asn Lys Ala Thr Pro Pro Asn Val 
225                 230                 235                 240 


Glu Asn Gly Gly Gly Gly Ser Arg Gly Gly Gly Gly Ser Gly Gly Gly 
                245                 250                 255     


Gly Ser Ile Val Gly Gly Lys Arg Ala Gln Leu Gly Asp Leu Pro Trp 
            260                 265                 270         


Gln Val Ala Ile Lys Asp Ala Ser Gly Ile Thr Cys Gly Gly Ile Tyr 
        275                 280                 285             


Ile Gly Gly Cys Trp Ile Leu Thr Ala Ala His Cys Leu Arg Ala Ser 
    290                 295                 300                 


Lys Thr His Arg Tyr Gln Ile Trp Thr Thr Val Val Asp Trp Ile His 
305                 310                 315                 320 


Pro Asp Leu Lys Arg Ile Val Ile Glu Tyr Val Asp Arg Ile Ile Phe 
                325                 330                 335     


His Glu Asn Tyr Asn Ala Gly Thr Tyr Gln Asn Asp Ile Ala Leu Ile 
            340                 345                 350         


Glu Met Lys Lys Asp Gly Asn Lys Lys Asp Cys Glu Leu Pro Arg Ser 
        355                 360                 365             


Ile Pro Ala Ala Val Pro Trp Ser Pro Tyr Leu Phe Gln Pro Gln Asp 
    370                 375                 380                 


Thr Cys Ile Val Ser Gly Trp Gly Arg Glu Lys Asp Asn Glu Arg Val 
385                 390                 395                 400 


Phe Ser Leu Gln Trp Gly Glu Val Lys Leu Ile Ser Gln Cys Ser Lys 
                405                 410                 415     


Phe Tyr Gly Asn Arg Phe Tyr Glu Lys Glu Met Glu Cys Ala Gly Thr 
            420                 425                 430         


Tyr Asp Gly Ser Ile Asp Ala Cys Lys Gly Asp Ser Gly Gly Pro Leu 
        435                 440                 445             


Val Cys Met Asp Ala Asn Gln Val Thr Tyr Val Trp Gly Val Val Ser 
    450                 455                 460                 


Trp Gly Glu Asn Cys Gly Lys Pro Glu Phe Pro Gly Val Tyr Thr Lys 
465                 470                 475                 480 


Val Ala Asn Tyr Phe Asp Trp Ile Ser Tyr His Val Gly Arg Pro Phe 
                485                 490                 495     


Ile Ser Gln Tyr Asn Val 
            500         


<210>  53
<211>  502
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  His-tagged non-glycosylated chimeric CR1b-FI protein amino acid 
       sequence

<400>  53

Met Arg Leu Leu Ala Lys Ile Ile Cys Leu Met Leu Trp Ala Ile Cys 
1               5                   10                  15      


Val Ala His His His His His His Gly Ser Ser Glu Asn Leu Tyr Phe 
            20                  25                  30          


Gln Gly Ser Ser Gly Gly His Cys Gln Ala Pro Asp His Phe Leu Phe 
        35                  40                  45              


Ala Lys Leu Lys Thr Gln Thr Gln Ala Ser Asp Phe Pro Ile Gly Thr 
    50                  55                  60                  


Ser Leu Lys Tyr Glu Cys Arg Pro Glu Tyr Tyr Gly Arg Pro Phe Ser 
65                  70                  75                  80  


Ile Thr Cys Leu Asp Asn Leu Val Trp Ser Ser Pro Lys Asp Val Cys 
                85                  90                  95      


Lys Arg Lys Ser Cys Lys Thr Pro Pro Asp Pro Val Asn Gly Met Val 
            100                 105                 110         


His Val Ile Thr Asp Ile Gln Val Gly Ser Arg Ile Gln Tyr Ser Cys 
        115                 120                 125             


Thr Thr Gly His Arg Leu Ile Gly His Ser Ser Ala Glu Cys Ile Leu 
    130                 135                 140                 


Ser Gly Asn Ala Ala His Trp Ser Thr Lys Pro Pro Ile Cys Gln Arg 
145                 150                 155                 160 


Ile Pro Cys Gly Leu Pro Pro Thr Ile Ala Asn Gly Asp Phe Ile Ser 
                165                 170                 175     


Thr Asn Arg Glu Asn Phe His Tyr Gly Ser Val Val Thr Tyr Arg Cys 
            180                 185                 190         


Asn Pro Gly Ser Gly Gly Arg Lys Val Phe Glu Leu Val Gly Glu Pro 
        195                 200                 205             


Ser Ile Tyr Cys Thr Ser Asn Asp Asp Gln Val Gly Ile Trp Ser Gly 
    210                 215                 220                 


Pro Ala Pro Gln Cys Ile Ile Pro Asn Lys Ala Thr Pro Pro Asn Val 
225                 230                 235                 240 


Glu Asn Gly Gly Gly Gly Ser Arg Gly Gly Gly Gly Ser Gly Gly Gly 
                245                 250                 255     


Gly Ser Ile Val Gly Gly Lys Arg Ala Gln Leu Gly Asp Leu Pro Trp 
            260                 265                 270         


Gln Val Ala Ile Lys Asp Ala Ser Gly Ile Thr Cys Gly Gly Ile Tyr 
        275                 280                 285             


Ile Gly Gly Cys Trp Ile Leu Thr Ala Ala His Cys Leu Arg Ala Ser 
    290                 295                 300                 


Lys Thr His Arg Tyr Gln Ile Trp Thr Thr Val Val Asp Trp Ile His 
305                 310                 315                 320 


Pro Asp Leu Lys Arg Ile Val Ile Glu Tyr Val Asp Arg Ile Ile Phe 
                325                 330                 335     


His Glu Asn Tyr Asn Ala Gly Thr Tyr Gln Asn Asp Ile Ala Leu Ile 
            340                 345                 350         


Glu Met Lys Lys Asp Gly Asn Lys Lys Asp Cys Glu Leu Pro Arg Ser 
        355                 360                 365             


Ile Pro Ala Ala Val Pro Trp Ser Pro Tyr Leu Phe Gln Pro Gln Asp 
    370                 375                 380                 


Thr Cys Ile Val Ser Gly Trp Gly Arg Glu Lys Asp Asn Glu Arg Val 
385                 390                 395                 400 


Phe Ser Leu Gln Trp Gly Glu Val Lys Leu Ile Ser Gln Cys Ser Lys 
                405                 410                 415     


Phe Tyr Gly Asn Arg Phe Tyr Glu Lys Glu Met Glu Cys Ala Gly Thr 
            420                 425                 430         


Tyr Asp Gly Ser Ile Asp Ala Cys Lys Gly Asp Ser Gly Gly Pro Leu 
        435                 440                 445             


Val Cys Met Asp Ala Asn Gln Val Thr Tyr Val Trp Gly Val Val Ser 
    450                 455                 460                 


Trp Gly Glu Asn Cys Gly Lys Pro Glu Phe Pro Gly Val Tyr Thr Lys 
465                 470                 475                 480 


Val Ala Asn Tyr Phe Asp Trp Ile Ser Tyr His Val Gly Arg Pro Phe 
                485                 490                 495     


Ile Ser Gln Tyr Asn Val 
            500         


<210>  54
<211>  484
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  His-tagged glycosylated chimeric CR1a-FI protein amino acid 
       sequence (without signal peptide)

<400>  54

His His His His His His Gly Ser Ser Glu Asn Leu Tyr Phe Gln Gly 
1               5                   10                  15      


Ser Ser Gly Gly His Cys Gln Ala Pro Asp His Phe Leu Phe Ala Lys 
            20                  25                  30          


Leu Lys Thr Gln Thr Asn Ala Ser Asp Phe Pro Ile Gly Thr Ser Leu 
        35                  40                  45              


Lys Tyr Glu Cys Arg Pro Glu Tyr Tyr Gly Arg Pro Phe Ser Ile Thr 
    50                  55                  60                  


Cys Leu Asp Asn Leu Val Trp Ser Ser Pro Lys Asp Val Cys Lys Arg 
65                  70                  75                  80  


Lys Ser Cys Lys Thr Pro Pro Asp Pro Val Asn Gly Met Val His Val 
                85                  90                  95      


Ile Thr Asp Ile Gln Val Gly Ser Arg Ile Asn Tyr Ser Cys Thr Thr 
            100                 105                 110         


Gly His Arg Leu Ile Gly His Ser Ser Ala Glu Cys Ile Leu Ser Gly 
        115                 120                 125             


Asn Ala Ala His Trp Ser Thr Lys Pro Pro Ile Cys Gln Arg Ile Pro 
    130                 135                 140                 


Cys Gly Leu Pro Pro Thr Ile Ala Asn Gly Asp Phe Ile Ser Thr Asn 
145                 150                 155                 160 


Arg Glu Asn Phe His Tyr Gly Ser Val Val Thr Tyr Arg Cys Asn Pro 
                165                 170                 175     


Gly Ser Gly Gly Arg Lys Val Phe Glu Leu Val Gly Glu Pro Ser Ile 
            180                 185                 190         


Tyr Cys Thr Ser Asn Asp Asp Gln Val Gly Ile Trp Ser Gly Pro Ala 
        195                 200                 205             


Pro Gln Cys Ile Ile Pro Asn Lys Ala Thr Pro Pro Asn Val Glu Asn 
    210                 215                 220                 


Gly Gly Gly Gly Ser Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
225                 230                 235                 240 


Ile Val Gly Gly Lys Arg Ala Gln Leu Gly Asp Leu Pro Trp Gln Val 
                245                 250                 255     


Ala Ile Lys Asp Ala Ser Gly Ile Thr Cys Gly Gly Ile Tyr Ile Gly 
            260                 265                 270         


Gly Cys Trp Ile Leu Thr Ala Ala His Cys Leu Arg Ala Ser Lys Thr 
        275                 280                 285             


His Arg Tyr Gln Ile Trp Thr Thr Val Val Asp Trp Ile His Pro Asp 
    290                 295                 300                 


Leu Lys Arg Ile Val Ile Glu Tyr Val Asp Arg Ile Ile Phe His Glu 
305                 310                 315                 320 


Asn Tyr Asn Ala Gly Thr Tyr Gln Asn Asp Ile Ala Leu Ile Glu Met 
                325                 330                 335     


Lys Lys Asp Gly Asn Lys Lys Asp Cys Glu Leu Pro Arg Ser Ile Pro 
            340                 345                 350         


Ala Ala Val Pro Trp Ser Pro Tyr Leu Phe Gln Pro Asn Asp Thr Cys 
        355                 360                 365             


Ile Val Ser Gly Trp Gly Arg Glu Lys Asp Asn Glu Arg Val Phe Ser 
    370                 375                 380                 


Leu Gln Trp Gly Glu Val Lys Leu Ile Ser Asn Cys Ser Lys Phe Tyr 
385                 390                 395                 400 


Gly Asn Arg Phe Tyr Glu Lys Glu Met Glu Cys Ala Gly Thr Tyr Asp 
                405                 410                 415     


Gly Ser Ile Asp Ala Cys Lys Gly Asp Ser Gly Gly Pro Leu Val Cys 
            420                 425                 430         


Met Asp Ala Asn Asn Val Thr Tyr Val Trp Gly Val Val Ser Trp Gly 
        435                 440                 445             


Glu Asn Cys Gly Lys Pro Glu Phe Pro Gly Val Tyr Thr Lys Val Ala 
    450                 455                 460                 


Asn Tyr Phe Asp Trp Ile Ser Tyr His Val Gly Arg Pro Phe Ile Ser 
465                 470                 475                 480 


Gln Tyr Asn Val 
                


<210>  55
<211>  484
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  His-tagged glycosylated chimeric CR1b-FI protein amino acid 
       sequence (without signal peptide)

<400>  55

His His His His His His Gly Ser Ser Glu Asn Leu Tyr Phe Gln Gly 
1               5                   10                  15      


Ser Ser Gly Gly His Cys Gln Ala Pro Asp His Phe Leu Phe Ala Lys 
            20                  25                  30          


Leu Lys Thr Gln Thr Asn Ala Ser Asp Phe Pro Ile Gly Thr Ser Leu 
        35                  40                  45              


Lys Tyr Glu Cys Arg Pro Glu Tyr Tyr Gly Arg Pro Phe Ser Ile Thr 
    50                  55                  60                  


Cys Leu Asp Asn Leu Val Trp Ser Ser Pro Lys Asp Val Cys Lys Arg 
65                  70                  75                  80  


Lys Ser Cys Lys Thr Pro Pro Asp Pro Val Asn Gly Met Val His Val 
                85                  90                  95      


Ile Thr Asp Ile Gln Val Gly Ser Arg Ile Asn Tyr Ser Cys Thr Thr 
            100                 105                 110         


Gly His Arg Leu Ile Gly His Ser Ser Ala Glu Cys Ile Leu Ser Gly 
        115                 120                 125             


Asn Thr Ala His Trp Ser Thr Lys Pro Pro Ile Cys Gln Arg Ile Pro 
    130                 135                 140                 


Cys Gly Leu Pro Pro Thr Ile Ala Asn Gly Asp Phe Ile Ser Thr Asn 
145                 150                 155                 160 


Arg Glu Asn Phe His Tyr Gly Ser Val Val Thr Tyr Arg Cys Asn Leu 
                165                 170                 175     


Gly Ser Arg Gly Arg Lys Val Phe Glu Leu Val Gly Glu Pro Ser Ile 
            180                 185                 190         


Tyr Cys Thr Ser Asn Asp Asp Gln Val Gly Ile Trp Ser Gly Pro Ala 
        195                 200                 205             


Pro Gln Cys Ile Ile Pro Asn Lys Ala Thr Pro Pro Asn Val Glu Asn 
    210                 215                 220                 


Gly Gly Gly Gly Ser Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
225                 230                 235                 240 


Ile Val Gly Gly Lys Arg Ala Gln Leu Gly Asp Leu Pro Trp Gln Val 
                245                 250                 255     


Ala Ile Lys Asp Ala Ser Gly Ile Thr Cys Gly Gly Ile Tyr Ile Gly 
            260                 265                 270         


Gly Cys Trp Ile Leu Thr Ala Ala His Cys Leu Arg Ala Ser Lys Thr 
        275                 280                 285             


His Arg Tyr Gln Ile Trp Thr Thr Val Val Asp Trp Ile His Pro Asp 
    290                 295                 300                 


Leu Lys Arg Ile Val Ile Glu Tyr Val Asp Arg Ile Ile Phe His Glu 
305                 310                 315                 320 


Asn Tyr Asn Ala Gly Thr Tyr Gln Asn Asp Ile Ala Leu Ile Glu Met 
                325                 330                 335     


Lys Lys Asp Gly Asn Lys Lys Asp Cys Glu Leu Pro Arg Ser Ile Pro 
            340                 345                 350         


Ala Ala Val Pro Trp Ser Pro Tyr Leu Phe Gln Pro Asn Asp Thr Cys 
        355                 360                 365             


Ile Val Ser Gly Trp Gly Arg Glu Lys Asp Asn Glu Arg Val Phe Ser 
    370                 375                 380                 


Leu Gln Trp Gly Glu Val Lys Leu Ile Ser Asn Cys Ser Lys Phe Tyr 
385                 390                 395                 400 


Gly Asn Arg Phe Tyr Glu Lys Glu Met Glu Cys Ala Gly Thr Tyr Asp 
                405                 410                 415     


Gly Ser Ile Asp Ala Cys Lys Gly Asp Ser Gly Gly Pro Leu Val Cys 
            420                 425                 430         


Met Asp Ala Asn Asn Val Thr Tyr Val Trp Gly Val Val Ser Trp Gly 
        435                 440                 445             


Glu Asn Cys Gly Lys Pro Glu Phe Pro Gly Val Tyr Thr Lys Val Ala 
    450                 455                 460                 


Asn Tyr Phe Asp Trp Ile Ser Tyr His Val Gly Arg Pro Phe Ile Ser 
465                 470                 475                 480 


Gln Tyr Asn Val 
                


<210>  56
<211>  484
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  His-tagged non-glycosylated chimeric CR1a-FI protein amino acid 
       sequence (without signal peptide)

<400>  56

His His His His His His Gly Ser Ser Glu Asn Leu Tyr Phe Gln Gly 
1               5                   10                  15      


Ser Ser Gly Gly His Cys Gln Ala Pro Asp His Phe Leu Phe Ala Lys 
            20                  25                  30          


Leu Lys Thr Gln Thr Gln Ala Ser Asp Phe Pro Ile Gly Thr Ser Leu 
        35                  40                  45              


Lys Tyr Glu Cys Arg Pro Glu Tyr Tyr Gly Arg Pro Phe Ser Ile Thr 
    50                  55                  60                  


Cys Leu Asp Asn Leu Val Trp Ser Ser Pro Lys Asp Val Cys Lys Arg 
65                  70                  75                  80  


Lys Ser Cys Lys Thr Pro Pro Asp Pro Val Asn Gly Met Val His Val 
                85                  90                  95      


Ile Thr Asp Ile Gln Val Gly Ser Arg Ile Gln Tyr Ser Cys Thr Thr 
            100                 105                 110         


Gly His Arg Leu Ile Gly His Ser Ser Ala Glu Cys Ile Leu Ser Gly 
        115                 120                 125             


Asn Ala Ala His Trp Ser Thr Lys Pro Pro Ile Cys Gln Arg Ile Pro 
    130                 135                 140                 


Cys Gly Leu Pro Pro Thr Ile Ala Asn Gly Asp Phe Ile Ser Thr Asn 
145                 150                 155                 160 


Arg Glu Asn Phe His Tyr Gly Ser Val Val Thr Tyr Arg Cys Asn Pro 
                165                 170                 175     


Gly Ser Gly Gly Arg Lys Val Phe Glu Leu Val Gly Glu Pro Ser Ile 
            180                 185                 190         


Tyr Cys Thr Ser Asn Asp Asp Gln Val Gly Ile Trp Ser Gly Pro Ala 
        195                 200                 205             


Pro Gln Cys Ile Ile Pro Asn Lys Ala Thr Pro Pro Asn Val Glu Asn 
    210                 215                 220                 


Gly Gly Gly Gly Ser Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
225                 230                 235                 240 


Ile Val Gly Gly Lys Arg Ala Gln Leu Gly Asp Leu Pro Trp Gln Val 
                245                 250                 255     


Ala Ile Lys Asp Ala Ser Gly Ile Thr Cys Gly Gly Ile Tyr Ile Gly 
            260                 265                 270         


Gly Cys Trp Ile Leu Thr Ala Ala His Cys Leu Arg Ala Ser Lys Thr 
        275                 280                 285             


His Arg Tyr Gln Ile Trp Thr Thr Val Val Asp Trp Ile His Pro Asp 
    290                 295                 300                 


Leu Lys Arg Ile Val Ile Glu Tyr Val Asp Arg Ile Ile Phe His Glu 
305                 310                 315                 320 


Asn Tyr Asn Ala Gly Thr Tyr Gln Asn Asp Ile Ala Leu Ile Glu Met 
                325                 330                 335     


Lys Lys Asp Gly Asn Lys Lys Asp Cys Glu Leu Pro Arg Ser Ile Pro 
            340                 345                 350         


Ala Ala Val Pro Trp Ser Pro Tyr Leu Phe Gln Pro Gln Asp Thr Cys 
        355                 360                 365             


Ile Val Ser Gly Trp Gly Arg Glu Lys Asp Asn Glu Arg Val Phe Ser 
    370                 375                 380                 


Leu Gln Trp Gly Glu Val Lys Leu Ile Ser Gln Cys Ser Lys Phe Tyr 
385                 390                 395                 400 


Gly Asn Arg Phe Tyr Glu Lys Glu Met Glu Cys Ala Gly Thr Tyr Asp 
                405                 410                 415     


Gly Ser Ile Asp Ala Cys Lys Gly Asp Ser Gly Gly Pro Leu Val Cys 
            420                 425                 430         


Met Asp Ala Asn Gln Val Thr Tyr Val Trp Gly Val Val Ser Trp Gly 
        435                 440                 445             


Glu Asn Cys Gly Lys Pro Glu Phe Pro Gly Val Tyr Thr Lys Val Ala 
    450                 455                 460                 


Asn Tyr Phe Asp Trp Ile Ser Tyr His Val Gly Arg Pro Phe Ile Ser 
465                 470                 475                 480 


Gln Tyr Asn Val 
                


<210>  57
<211>  484
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  His-tagged non-glycosylated chimeric CR1b-FI protein amino acid 
       sequence (without signal peptide)

<400>  57

His His His His His His Gly Ser Ser Glu Asn Leu Tyr Phe Gln Gly 
1               5                   10                  15      


Ser Ser Gly Gly His Cys Gln Ala Pro Asp His Phe Leu Phe Ala Lys 
            20                  25                  30          


Leu Lys Thr Gln Thr Gln Ala Ser Asp Phe Pro Ile Gly Thr Ser Leu 
        35                  40                  45              


Lys Tyr Glu Cys Arg Pro Glu Tyr Tyr Gly Arg Pro Phe Ser Ile Thr 
    50                  55                  60                  


Cys Leu Asp Asn Leu Val Trp Ser Ser Pro Lys Asp Val Cys Lys Arg 
65                  70                  75                  80  


Lys Ser Cys Lys Thr Pro Pro Asp Pro Val Asn Gly Met Val His Val 
                85                  90                  95      


Ile Thr Asp Ile Gln Val Gly Ser Arg Ile Gln Tyr Ser Cys Thr Thr 
            100                 105                 110         


Gly His Arg Leu Ile Gly His Ser Ser Ala Glu Cys Ile Leu Ser Gly 
        115                 120                 125             


Asn Ala Ala His Trp Ser Thr Lys Pro Pro Ile Cys Gln Arg Ile Pro 
    130                 135                 140                 


Cys Gly Leu Pro Pro Thr Ile Ala Asn Gly Asp Phe Ile Ser Thr Asn 
145                 150                 155                 160 


Arg Glu Asn Phe His Tyr Gly Ser Val Val Thr Tyr Arg Cys Asn Pro 
                165                 170                 175     


Gly Ser Gly Gly Arg Lys Val Phe Glu Leu Val Gly Glu Pro Ser Ile 
            180                 185                 190         


Tyr Cys Thr Ser Asn Asp Asp Gln Val Gly Ile Trp Ser Gly Pro Ala 
        195                 200                 205             


Pro Gln Cys Ile Ile Pro Asn Lys Ala Thr Pro Pro Asn Val Glu Asn 
    210                 215                 220                 


Gly Gly Gly Gly Ser Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
225                 230                 235                 240 


Ile Val Gly Gly Lys Arg Ala Gln Leu Gly Asp Leu Pro Trp Gln Val 
                245                 250                 255     


Ala Ile Lys Asp Ala Ser Gly Ile Thr Cys Gly Gly Ile Tyr Ile Gly 
            260                 265                 270         


Gly Cys Trp Ile Leu Thr Ala Ala His Cys Leu Arg Ala Ser Lys Thr 
        275                 280                 285             


His Arg Tyr Gln Ile Trp Thr Thr Val Val Asp Trp Ile His Pro Asp 
    290                 295                 300                 


Leu Lys Arg Ile Val Ile Glu Tyr Val Asp Arg Ile Ile Phe His Glu 
305                 310                 315                 320 


Asn Tyr Asn Ala Gly Thr Tyr Gln Asn Asp Ile Ala Leu Ile Glu Met 
                325                 330                 335     


Lys Lys Asp Gly Asn Lys Lys Asp Cys Glu Leu Pro Arg Ser Ile Pro 
            340                 345                 350         


Ala Ala Val Pro Trp Ser Pro Tyr Leu Phe Gln Pro Gln Asp Thr Cys 
        355                 360                 365             


Ile Val Ser Gly Trp Gly Arg Glu Lys Asp Asn Glu Arg Val Phe Ser 
    370                 375                 380                 


Leu Gln Trp Gly Glu Val Lys Leu Ile Ser Gln Cys Ser Lys Phe Tyr 
385                 390                 395                 400 


Gly Asn Arg Phe Tyr Glu Lys Glu Met Glu Cys Ala Gly Thr Tyr Asp 
                405                 410                 415     


Gly Ser Ile Asp Ala Cys Lys Gly Asp Ser Gly Gly Pro Leu Val Cys 
            420                 425                 430         


Met Asp Ala Asn Gln Val Thr Tyr Val Trp Gly Val Val Ser Trp Gly 
        435                 440                 445             


Glu Asn Cys Gly Lys Pro Glu Phe Pro Gly Val Tyr Thr Lys Val Ala 
    450                 455                 460                 


Asn Tyr Phe Asp Trp Ile Ser Tyr His Val Gly Arg Pro Phe Ile Ser 
465                 470                 475                 480 


Gln Tyr Asn Val 
                


<210>  58
<211>  465
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glycosylated chimeric CR1a-FI protein amino acid sequence 
       (without signal peptide)

<400>  58

Gly His Cys Gln Ala Pro Asp His Phe Leu Phe Ala Lys Leu Lys Thr 
1               5                   10                  15      


Gln Thr Asn Ala Ser Asp Phe Pro Ile Gly Thr Ser Leu Lys Tyr Glu 
            20                  25                  30          


Cys Arg Pro Glu Tyr Tyr Gly Arg Pro Phe Ser Ile Thr Cys Leu Asp 
        35                  40                  45              


Asn Leu Val Trp Ser Ser Pro Lys Asp Val Cys Lys Arg Lys Ser Cys 
    50                  55                  60                  


Lys Thr Pro Pro Asp Pro Val Asn Gly Met Val His Val Ile Thr Asp 
65                  70                  75                  80  


Ile Gln Val Gly Ser Arg Ile Asn Tyr Ser Cys Thr Thr Gly His Arg 
                85                  90                  95      


Leu Ile Gly His Ser Ser Ala Glu Cys Ile Leu Ser Gly Asn Ala Ala 
            100                 105                 110         


His Trp Ser Thr Lys Pro Pro Ile Cys Gln Arg Ile Pro Cys Gly Leu 
        115                 120                 125             


Pro Pro Thr Ile Ala Asn Gly Asp Phe Ile Ser Thr Asn Arg Glu Asn 
    130                 135                 140                 


Phe His Tyr Gly Ser Val Val Thr Tyr Arg Cys Asn Pro Gly Ser Gly 
145                 150                 155                 160 


Gly Arg Lys Val Phe Glu Leu Val Gly Glu Pro Ser Ile Tyr Cys Thr 
                165                 170                 175     


Ser Asn Asp Asp Gln Val Gly Ile Trp Ser Gly Pro Ala Pro Gln Cys 
            180                 185                 190         


Ile Ile Pro Asn Lys Ala Thr Pro Pro Asn Val Glu Asn Gly Gly Gly 
        195                 200                 205             


Gly Ser Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ile Val Gly 
    210                 215                 220                 


Gly Lys Arg Ala Gln Leu Gly Asp Leu Pro Trp Gln Val Ala Ile Lys 
225                 230                 235                 240 


Asp Ala Ser Gly Ile Thr Cys Gly Gly Ile Tyr Ile Gly Gly Cys Trp 
                245                 250                 255     


Ile Leu Thr Ala Ala His Cys Leu Arg Ala Ser Lys Thr His Arg Tyr 
            260                 265                 270         


Gln Ile Trp Thr Thr Val Val Asp Trp Ile His Pro Asp Leu Lys Arg 
        275                 280                 285             


Ile Val Ile Glu Tyr Val Asp Arg Ile Ile Phe His Glu Asn Tyr Asn 
    290                 295                 300                 


Ala Gly Thr Tyr Gln Asn Asp Ile Ala Leu Ile Glu Met Lys Lys Asp 
305                 310                 315                 320 


Gly Asn Lys Lys Asp Cys Glu Leu Pro Arg Ser Ile Pro Ala Ala Val 
                325                 330                 335     


Pro Trp Ser Pro Tyr Leu Phe Gln Pro Asn Asp Thr Cys Ile Val Ser 
            340                 345                 350         


Gly Trp Gly Arg Glu Lys Asp Asn Glu Arg Val Phe Ser Leu Gln Trp 
        355                 360                 365             


Gly Glu Val Lys Leu Ile Ser Asn Cys Ser Lys Phe Tyr Gly Asn Arg 
    370                 375                 380                 


Phe Tyr Glu Lys Glu Met Glu Cys Ala Gly Thr Tyr Asp Gly Ser Ile 
385                 390                 395                 400 


Asp Ala Cys Lys Gly Asp Ser Gly Gly Pro Leu Val Cys Met Asp Ala 
                405                 410                 415     


Asn Asn Val Thr Tyr Val Trp Gly Val Val Ser Trp Gly Glu Asn Cys 
            420                 425                 430         


Gly Lys Pro Glu Phe Pro Gly Val Tyr Thr Lys Val Ala Asn Tyr Phe 
        435                 440                 445             


Asp Trp Ile Ser Tyr His Val Gly Arg Pro Phe Ile Ser Gln Tyr Asn 
    450                 455                 460                 


Val 
465 


<210>  59
<211>  465
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glycosylated chimeric CR1b-FI protein amino acid sequence 
       (without signal peptide)

<400>  59

Gly His Cys Gln Ala Pro Asp His Phe Leu Phe Ala Lys Leu Lys Thr 
1               5                   10                  15      


Gln Thr Asn Ala Ser Asp Phe Pro Ile Gly Thr Ser Leu Lys Tyr Glu 
            20                  25                  30          


Cys Arg Pro Glu Tyr Tyr Gly Arg Pro Phe Ser Ile Thr Cys Leu Asp 
        35                  40                  45              


Asn Leu Val Trp Ser Ser Pro Lys Asp Val Cys Lys Arg Lys Ser Cys 
    50                  55                  60                  


Lys Thr Pro Pro Asp Pro Val Asn Gly Met Val His Val Ile Thr Asp 
65                  70                  75                  80  


Ile Gln Val Gly Ser Arg Ile Asn Tyr Ser Cys Thr Thr Gly His Arg 
                85                  90                  95      


Leu Ile Gly His Ser Ser Ala Glu Cys Ile Leu Ser Gly Asn Thr Ala 
            100                 105                 110         


His Trp Ser Thr Lys Pro Pro Ile Cys Gln Arg Ile Pro Cys Gly Leu 
        115                 120                 125             


Pro Pro Thr Ile Ala Asn Gly Asp Phe Ile Ser Thr Asn Arg Glu Asn 
    130                 135                 140                 


Phe His Tyr Gly Ser Val Val Thr Tyr Arg Cys Asn Leu Gly Ser Arg 
145                 150                 155                 160 


Gly Arg Lys Val Phe Glu Leu Val Gly Glu Pro Ser Ile Tyr Cys Thr 
                165                 170                 175     


Ser Asn Asp Asp Gln Val Gly Ile Trp Ser Gly Pro Ala Pro Gln Cys 
            180                 185                 190         


Ile Ile Pro Asn Lys Ala Thr Pro Pro Asn Val Glu Asn Gly Gly Gly 
        195                 200                 205             


Gly Ser Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ile Val Gly 
    210                 215                 220                 


Gly Lys Arg Ala Gln Leu Gly Asp Leu Pro Trp Gln Val Ala Ile Lys 
225                 230                 235                 240 


Asp Ala Ser Gly Ile Thr Cys Gly Gly Ile Tyr Ile Gly Gly Cys Trp 
                245                 250                 255     


Ile Leu Thr Ala Ala His Cys Leu Arg Ala Ser Lys Thr His Arg Tyr 
            260                 265                 270         


Gln Ile Trp Thr Thr Val Val Asp Trp Ile His Pro Asp Leu Lys Arg 
        275                 280                 285             


Ile Val Ile Glu Tyr Val Asp Arg Ile Ile Phe His Glu Asn Tyr Asn 
    290                 295                 300                 


Ala Gly Thr Tyr Gln Asn Asp Ile Ala Leu Ile Glu Met Lys Lys Asp 
305                 310                 315                 320 


Gly Asn Lys Lys Asp Cys Glu Leu Pro Arg Ser Ile Pro Ala Ala Val 
                325                 330                 335     


Pro Trp Ser Pro Tyr Leu Phe Gln Pro Asn Asp Thr Cys Ile Val Ser 
            340                 345                 350         


Gly Trp Gly Arg Glu Lys Asp Asn Glu Arg Val Phe Ser Leu Gln Trp 
        355                 360                 365             


Gly Glu Val Lys Leu Ile Ser Asn Cys Ser Lys Phe Tyr Gly Asn Arg 
    370                 375                 380                 


Phe Tyr Glu Lys Glu Met Glu Cys Ala Gly Thr Tyr Asp Gly Ser Ile 
385                 390                 395                 400 


Asp Ala Cys Lys Gly Asp Ser Gly Gly Pro Leu Val Cys Met Asp Ala 
                405                 410                 415     


Asn Asn Val Thr Tyr Val Trp Gly Val Val Ser Trp Gly Glu Asn Cys 
            420                 425                 430         


Gly Lys Pro Glu Phe Pro Gly Val Tyr Thr Lys Val Ala Asn Tyr Phe 
        435                 440                 445             


Asp Trp Ile Ser Tyr His Val Gly Arg Pro Phe Ile Ser Gln Tyr Asn 
    450                 455                 460                 


Val 
465 


<210>  60
<211>  465
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  non-glycosylated chimeric CR1a-FI protein amino acid sequence 
       (without signal peptide)

<400>  60

Gly His Cys Gln Ala Pro Asp His Phe Leu Phe Ala Lys Leu Lys Thr 
1               5                   10                  15      


Gln Thr Gln Ala Ser Asp Phe Pro Ile Gly Thr Ser Leu Lys Tyr Glu 
            20                  25                  30          


Cys Arg Pro Glu Tyr Tyr Gly Arg Pro Phe Ser Ile Thr Cys Leu Asp 
        35                  40                  45              


Asn Leu Val Trp Ser Ser Pro Lys Asp Val Cys Lys Arg Lys Ser Cys 
    50                  55                  60                  


Lys Thr Pro Pro Asp Pro Val Asn Gly Met Val His Val Ile Thr Asp 
65                  70                  75                  80  


Ile Gln Val Gly Ser Arg Ile Gln Tyr Ser Cys Thr Thr Gly His Arg 
                85                  90                  95      


Leu Ile Gly His Ser Ser Ala Glu Cys Ile Leu Ser Gly Asn Ala Ala 
            100                 105                 110         


His Trp Ser Thr Lys Pro Pro Ile Cys Gln Arg Ile Pro Cys Gly Leu 
        115                 120                 125             


Pro Pro Thr Ile Ala Asn Gly Asp Phe Ile Ser Thr Asn Arg Glu Asn 
    130                 135                 140                 


Phe His Tyr Gly Ser Val Val Thr Tyr Arg Cys Asn Pro Gly Ser Gly 
145                 150                 155                 160 


Gly Arg Lys Val Phe Glu Leu Val Gly Glu Pro Ser Ile Tyr Cys Thr 
                165                 170                 175     


Ser Asn Asp Asp Gln Val Gly Ile Trp Ser Gly Pro Ala Pro Gln Cys 
            180                 185                 190         


Ile Ile Pro Asn Lys Ala Thr Pro Pro Asn Val Glu Asn Gly Gly Gly 
        195                 200                 205             


Gly Ser Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ile Val Gly 
    210                 215                 220                 


Gly Lys Arg Ala Gln Leu Gly Asp Leu Pro Trp Gln Val Ala Ile Lys 
225                 230                 235                 240 


Asp Ala Ser Gly Ile Thr Cys Gly Gly Ile Tyr Ile Gly Gly Cys Trp 
                245                 250                 255     


Ile Leu Thr Ala Ala His Cys Leu Arg Ala Ser Lys Thr His Arg Tyr 
            260                 265                 270         


Gln Ile Trp Thr Thr Val Val Asp Trp Ile His Pro Asp Leu Lys Arg 
        275                 280                 285             


Ile Val Ile Glu Tyr Val Asp Arg Ile Ile Phe His Glu Asn Tyr Asn 
    290                 295                 300                 


Ala Gly Thr Tyr Gln Asn Asp Ile Ala Leu Ile Glu Met Lys Lys Asp 
305                 310                 315                 320 


Gly Asn Lys Lys Asp Cys Glu Leu Pro Arg Ser Ile Pro Ala Ala Val 
                325                 330                 335     


Pro Trp Ser Pro Tyr Leu Phe Gln Pro Gln Asp Thr Cys Ile Val Ser 
            340                 345                 350         


Gly Trp Gly Arg Glu Lys Asp Asn Glu Arg Val Phe Ser Leu Gln Trp 
        355                 360                 365             


Gly Glu Val Lys Leu Ile Ser Gln Cys Ser Lys Phe Tyr Gly Asn Arg 
    370                 375                 380                 


Phe Tyr Glu Lys Glu Met Glu Cys Ala Gly Thr Tyr Asp Gly Ser Ile 
385                 390                 395                 400 


Asp Ala Cys Lys Gly Asp Ser Gly Gly Pro Leu Val Cys Met Asp Ala 
                405                 410                 415     


Asn Gln Val Thr Tyr Val Trp Gly Val Val Ser Trp Gly Glu Asn Cys 
            420                 425                 430         


Gly Lys Pro Glu Phe Pro Gly Val Tyr Thr Lys Val Ala Asn Tyr Phe 
        435                 440                 445             


Asp Trp Ile Ser Tyr His Val Gly Arg Pro Phe Ile Ser Gln Tyr Asn 
    450                 455                 460                 


Val 
465 


<210>  61
<211>  465
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  non-glycosylated chimeric CR1b-FI protein amino acid sequence 
       (without signal peptide)

<400>  61

Gly His Cys Gln Ala Pro Asp His Phe Leu Phe Ala Lys Leu Lys Thr 
1               5                   10                  15      


Gln Thr Gln Ala Ser Asp Phe Pro Ile Gly Thr Ser Leu Lys Tyr Glu 
            20                  25                  30          


Cys Arg Pro Glu Tyr Tyr Gly Arg Pro Phe Ser Ile Thr Cys Leu Asp 
        35                  40                  45              


Asn Leu Val Trp Ser Ser Pro Lys Asp Val Cys Lys Arg Lys Ser Cys 
    50                  55                  60                  


Lys Thr Pro Pro Asp Pro Val Asn Gly Met Val His Val Ile Thr Asp 
65                  70                  75                  80  


Ile Gln Val Gly Ser Arg Ile Gln Tyr Ser Cys Thr Thr Gly His Arg 
                85                  90                  95      


Leu Ile Gly His Ser Ser Ala Glu Cys Ile Leu Ser Gly Asn Ala Ala 
            100                 105                 110         


His Trp Ser Thr Lys Pro Pro Ile Cys Gln Arg Ile Pro Cys Gly Leu 
        115                 120                 125             


Pro Pro Thr Ile Ala Asn Gly Asp Phe Ile Ser Thr Asn Arg Glu Asn 
    130                 135                 140                 


Phe His Tyr Gly Ser Val Val Thr Tyr Arg Cys Asn Pro Gly Ser Gly 
145                 150                 155                 160 


Gly Arg Lys Val Phe Glu Leu Val Gly Glu Pro Ser Ile Tyr Cys Thr 
                165                 170                 175     


Ser Asn Asp Asp Gln Val Gly Ile Trp Ser Gly Pro Ala Pro Gln Cys 
            180                 185                 190         


Ile Ile Pro Asn Lys Ala Thr Pro Pro Asn Val Glu Asn Gly Gly Gly 
        195                 200                 205             


Gly Ser Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ile Val Gly 
    210                 215                 220                 


Gly Lys Arg Ala Gln Leu Gly Asp Leu Pro Trp Gln Val Ala Ile Lys 
225                 230                 235                 240 


Asp Ala Ser Gly Ile Thr Cys Gly Gly Ile Tyr Ile Gly Gly Cys Trp 
                245                 250                 255     


Ile Leu Thr Ala Ala His Cys Leu Arg Ala Ser Lys Thr His Arg Tyr 
            260                 265                 270         


Gln Ile Trp Thr Thr Val Val Asp Trp Ile His Pro Asp Leu Lys Arg 
        275                 280                 285             


Ile Val Ile Glu Tyr Val Asp Arg Ile Ile Phe His Glu Asn Tyr Asn 
    290                 295                 300                 


Ala Gly Thr Tyr Gln Asn Asp Ile Ala Leu Ile Glu Met Lys Lys Asp 
305                 310                 315                 320 


Gly Asn Lys Lys Asp Cys Glu Leu Pro Arg Ser Ile Pro Ala Ala Val 
                325                 330                 335     


Pro Trp Ser Pro Tyr Leu Phe Gln Pro Gln Asp Thr Cys Ile Val Ser 
            340                 345                 350         


Gly Trp Gly Arg Glu Lys Asp Asn Glu Arg Val Phe Ser Leu Gln Trp 
        355                 360                 365             


Gly Glu Val Lys Leu Ile Ser Gln Cys Ser Lys Phe Tyr Gly Asn Arg 
    370                 375                 380                 


Phe Tyr Glu Lys Glu Met Glu Cys Ala Gly Thr Tyr Asp Gly Ser Ile 
385                 390                 395                 400 


Asp Ala Cys Lys Gly Asp Ser Gly Gly Pro Leu Val Cys Met Asp Ala 
                405                 410                 415     


Asn Gln Val Thr Tyr Val Trp Gly Val Val Ser Trp Gly Glu Asn Cys 
            420                 425                 430         


Gly Lys Pro Glu Phe Pro Gly Val Tyr Thr Lys Val Ala Asn Tyr Phe 
        435                 440                 445             


Asp Trp Ile Ser Tyr His Val Gly Arg Pro Phe Ile Ser Gln Tyr Asn 
    450                 455                 460                 


Val 
465 


<210>  62
<211>  1526
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  His-tagged glycosylated chimeric CR1a-FI protein coding sequence

<400>  62
aagcttgcca ccatgagact gctggccaag atcatctgcc tgatgctgtg ggccatctgc       60

gtggcccacc accatcacca tcacggcagc agcgagaacc tgtacttcca aggatcttct      120

ggcggccact gtcaggcccc tgatcacttc ctgttcgcca agctgaaaac ccagaccaac      180

gccagcgact tccctatcgg caccagcctg aagtacgagt gcagacccga gtactacggc      240

agacccttca gcatcacctg tctggacaac ctcgtgtggt ctagccccaa ggacgtgtgc      300

aagagaaaga gctgcaagac ccctcctgat cctgtgaacg gcatggtgca cgtgatcacc      360

gacatccaag tgggcagcag aatcaactac agctgcacca ccggccacag actgatcgga      420

cactctagcg ccgagtgtat cctgagcggc aatgccgcac actggtccac caagcctcca      480

atctgccaga gaatcccttg cggcctgcct cctacaatcg ccaacggcga tttcatcagc      540

accaacagag agaacttcca ctacggctcc gtggtcacct acagatgcaa tcctggcagc      600

ggcggcagaa aggtgttcga acttgtgggc gagcccagca tctactgcac cagcaacgat      660

gaccaagtcg gcatttggag cggccctgct cctcagtgca tcatccccaa caaagccaca      720

cctcctaacg tggaaaatgg cggcggaggc tctagaggtg gcggaggatc tggcggaggc      780

ggatctatcg ttggaggaaa gagagcacag ctgggcgacc tgccttggca ggttgccatt      840

aaggatgcca gcggcatcac atgcggcggc atctatatcg gcggctgctg gattctgaca      900

gccgctcatt gtctgcgggc cagcaagacc caccggtatc agatttggac caccgtggtg      960

gactggattc accccgacct gaagcggatc gtgatcgagt acgtggaccg gatcatcttc     1020

cacgagaact acaacgccgg cacctaccag aacgatatcg ccctgatcga gatgaagaag     1080

gacggcaaca agaaggactg cgagctgcct agatctatcc cagccgctgt tccttggagc     1140

ccctacctgt tccagcctaa cgatacctgc atcgtgtccg gctggggcag agagaaggac     1200

aacgaaaggg tgttcagcct gcagtggggc gaagtgaagc tgatctccaa ctgcagcaag     1260

ttctacggca accggttcta cgagaaagaa atggaatgcg ccggcacata cgacggctcc     1320

atcgatgcct gtaaaggcga ttctggcgga cccctcgtgt gcatggatgc caacaatgtg     1380

acctacgtgt ggggcgtcgt gtcctgggga gagaattgtg gcaagcctga gttccccggc     1440

gtgtacacca aggtggccaa ctacttcgac tggatcagct accacgtggg cagaccattc     1500

atcagccagt acaacgttgc ggccgc                                          1526


<210>  63
<211>  1526
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  His-tagged glycosylated chimeric CR1b-FI protein coding sequence

<400>  63
aagcttgcca ccatgagact gctggccaag atcatctgcc tgatgctgtg ggccatctgc       60

gtggcccacc accatcacca tcacggcagc agcgagaacc tgtacttcca aggatcttct      120

ggcggccact gtcaggcccc tgatcacttc ctgttcgcca agctgaaaac ccagaccaac      180

gccagcgact tccctatcgg caccagcctg aagtacgagt gcagacccga gtactacggc      240

agacccttca gcatcacctg tctggacaac ctcgtgtggt ctagccccaa ggacgtgtgc      300

aagagaaaga gctgcaagac ccctcctgat cctgtgaacg gcatggtgca cgtgatcacc      360

gacatccaag tgggcagcag aatcaactac agctgcacca ccggccacag actgatcgga      420

cactctagcg ccgagtgtat cctgagcggc aacacagccc actggtccac caagcctcca      480

atctgccaga gaatcccttg cggcctgcct cctacaatcg ccaacggcga tttcatcagc      540

accaacagag agaacttcca ctacggctcc gtggtcacct acagatgcaa cctgggctcc      600

agaggccgga aggtgttcga acttgtgggc gagcctagca tctactgcac cagcaacgac      660

gaccaagtcg gcatttggag cggacctgct cctcagtgca tcatccccaa caaggccaca      720

cctcctaacg tggaaaatgg cggcggaggc tctagaggtg gcggaggatc tggcggaggc      780

ggatctatcg ttggaggaaa gagagcacag ctgggcgacc tgccttggca ggttgccatt      840

aaggatgcca gcggcatcac atgcggcggc atctatatcg gcggctgctg gattctgacc      900

gccgctcatt gtctgagagc cagcaagacc caccggtatc agatctggac caccgtggtg      960

gactggattc accccgacct gaagcggatc gtgatcgagt acgtggaccg gatcatcttc     1020

cacgagaact acaacgccgg cacctaccag aacgatatcg ccctgatcga gatgaagaag     1080

gacggcaaca agaaggactg cgagctgcct agatctatcc ctgccgctgt tccttggagc     1140

ccctacctgt tccagcctaa cgatacctgc atcgtgtccg gctggggcag agagaaggac     1200

aacgaaaggg tgttcagcct gcagtggggc gaagtgaagc tgatctccaa ctgcagcaag     1260

ttctacggca accggttcta cgagaaagaa atggaatgcg ccggcacata cgacggctcc     1320

atcgatgcct gtaaaggcga ttctggcgga cccctcgtgt gcatggatgc caacaatgtg     1380

acctacgtgt ggggcgtcgt gtcctgggga gagaattgtg gcaagcctga gttccccggc     1440

gtgtacacca aggtggccaa ctacttcgac tggatcagct accacgtggg cagaccattc     1500

atcagccagt acaacgttgc ggccgc                                          1526


<210>  64
<211>  1526
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  His-tagged non-glycosylated chimeric CR1a-FI protein coding 
       sequence

<400>  64
aagcttgcca ccatgagact gctggccaag atcatctgcc tgatgctgtg ggccatctgc       60

gtggcccacc accatcacca tcacggcagc agcgagaacc tgtacttcca aggatcttct      120

ggcggccact gtcaggcccc tgatcacttc ctgttcgcca agctgaaaac ccagacacag      180

gccagcgact tccctatcgg caccagcctg aagtacgagt gcagacccga gtactacggc      240

agacccttca gcatcacctg tctggacaac ctcgtgtggt ctagccccaa ggacgtgtgc      300

aagagaaaga gctgcaagac ccctcctgat cctgtgaacg gcatggtgca cgtgatcacc      360

gacatccaag tgggcagcag aatccagtac agctgcacca caggccacag actgatcggc      420

cactctagcg ccgagtgtat cctgtctggc aatgccgctc actggtccac caagcctcca      480

atctgccaga gaatcccttg cggcctgcct cctacaatcg ccaacggcga tttcatcagc      540

accaacagag agaacttcca ctacggctcc gtggtcacct acagatgcaa tcctggcagc      600

ggcggcagaa aggtgttcga acttgtgggc gagcccagca tctactgcac cagcaacgat      660

gaccaagtcg gcatttggag cggccctgct cctcagtgca tcatccccaa caaagccaca      720

cctcctaacg tggaaaatgg cggcggaggc tctagaggtg gcggaggatc tggcggaggc      780

ggatctatcg ttggaggaaa gagagcacag ctgggcgacc tgccttggca ggttgccatt      840

aaggatgcca gcggcatcac atgcggcggc atctatatcg gcggctgctg gattctcacc      900

gccgcacatt gtctgagagc cagcaagacc caccggtatc agatctggac caccgtggtg      960

gactggattc accccgacct gaagcggatc gtgatcgagt acgtggaccg gatcatcttc     1020

cacgagaact acaacgccgg cacctaccag aacgatatcg ccctgatcga gatgaagaag     1080

gacggcaaca agaaggactg cgagctgcct agatctatcc cagccgctgt tccttggagc     1140

ccctacctgt tccagcctca agatacctgc atcgtgtccg gctggggcag agagaaggac     1200

aacgaaaggg tgttcagcct gcagtggggc gaagtgaagc tgatctccca gtgcagcaag     1260

ttctacggca accggttcta cgagaaagaa atggaatgcg ccggcacata cgacggctcc     1320

atcgatgcct gtaaaggcga ttctggcgga cccctcgtgt gcatggatgc caatcaagtg     1380

acctacgtgt ggggcgtcgt gtcctgggga gagaattgtg gcaagcctga gttccccggc     1440

gtgtacacca aggtggccaa ctacttcgac tggatcagct accacgtggg cagaccattc     1500

atcagccagt acaacgttgc ggccgc                                          1526


<210>  65
<211>  1526
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  His-tagged non-glycosylated chimeric CR1b-FI protein coding 
       sequence

<400>  65
aagcttgcca ccatgagact gctggccaag atcatctgcc tgatgctgtg ggccatctgc       60

gtggcccacc accatcacca tcacggcagc agcgagaacc tgtacttcca aggatcttct      120

ggcggccact gtcaggcccc tgatcacttc ctgttcgcca agctgaaaac ccagacacag      180

gccagcgact tccctatcgg caccagcctg aagtacgagt gcagacccga gtactacggc      240

agacccttca gcatcacctg tctggacaac ctcgtgtggt ctagccccaa ggacgtgtgc      300

aagagaaaga gctgcaagac ccctcctgat cctgtgaacg gcatggtgca cgtgatcacc      360

gacatccaag tgggcagcag aatccagtac agctgcacca caggccacag actgatcggc      420

cactctagcg ccgagtgtat cctgagcgga aacacagccc actggtccac caagcctcca      480

atctgccaga gaatcccttg cggcctgcct cctacaatcg ccaacggcga tttcatcagc      540

accaacagag agaacttcca ctacggctcc gtggtcacct acagatgcaa cctgggctcc      600

agaggccgga aggtgttcga acttgtgggc gagcctagca tctactgcac cagcaacgac      660

gaccaagtcg gcatttggag cggacctgct cctcagtgca tcatccccaa caaggccaca      720

cctcctaacg tggaaaatgg cggcggaggc tctagaggtg gcggaggatc tggcggaggc      780

ggatctatcg ttggaggaaa gagagcacag ctgggcgacc tgccttggca ggttgccatt      840

aaggatgcca gcggcatcac atgcggcggc atctatatcg gcggctgctg gattctcacc      900

gccgctcatt gtctgagagc cagcaagacc caccggtatc agatctggac caccgtggtg      960

gactggattc accccgacct gaagcggatc gtgatcgagt acgtggaccg gatcatcttc     1020

cacgagaact acaacgccgg cacctaccag aacgatatcg ccctgatcga gatgaagaag     1080

gacggcaaca agaaggactg cgagctgcct agatctatcc ctgccgctgt tccttggagc     1140

ccctacctgt tccagcctca agatacctgc atcgtgtccg gctggggcag agagaaggac     1200

aacgaaaggg tgttcagcct gcagtggggc gaagtgaagc tgatctccca gtgcagcaag     1260

ttctacggca accggttcta cgagaaagaa atggaatgcg ccggcacata cgacggctcc     1320

atcgatgcct gtaaaggcga ttctggcgga cccctcgtgt gcatggatgc caatcaagtg     1380

acctacgtgt ggggcgtcgt gtcctgggga gagaattgtg gcaagcctga gttccccggc     1440

gtgtacacca aggtggccaa ctacttcgac tggatcagct accacgtggg cagaccattc     1500

atcagccagt acaacgttgc ggccgc                                          1526


<210>  66
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Consensus sequence for N-linked glycosylation


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = any amino acid except for P

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa = S or T

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa = any amino acid except for P

<400>  66

Asn Xaa Xaa Xaa 
1               


<210>  67
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  G4S-R-(G4S)4 linker

<400>  67

Gly Gly Gly Gly Ser Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15      


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
            20                  25      


<210>  68
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  G4S-K-(G4S)4 linker

<400>  68

Gly Gly Gly Gly Ser Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15      


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
            20                  25      


<210>  69
<211>  524
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glycosylated chimeric FH-FI protein amino acid sequence (with 
       signal peptide)

<400>  69

Met Arg Leu Leu Ala Lys Ile Ile Cys Leu Met Leu Trp Ala Ile Cys 
1               5                   10                  15      


Val Ala Glu Asp Cys Asn Glu Leu Pro Pro Arg Arg Asn Thr Glu Ile 
            20                  25                  30          


Leu Thr Gly Ser Trp Ser Asp Gln Thr Tyr Pro Glu Gly Thr Gln Ala 
        35                  40                  45              


Ile Tyr Lys Cys Arg Pro Gly Tyr Arg Ser Leu Gly Asn Ile Ile Met 
    50                  55                  60                  


Val Cys Arg Lys Gly Glu Trp Val Ala Leu Asn Pro Leu Arg Lys Cys 
65                  70                  75                  80  


Gln Lys Arg Pro Cys Gly His Pro Gly Asp Thr Pro Phe Gly Thr Phe 
                85                  90                  95      


Thr Leu Thr Gly Gly Asn Val Phe Glu Tyr Gly Val Lys Ala Val Tyr 
            100                 105                 110         


Thr Cys Asn Glu Gly Tyr Gln Leu Leu Gly Glu Ile Asn Tyr Arg Glu 
        115                 120                 125             


Cys Asp Thr Asp Gly Trp Thr Asn Asp Ile Pro Ile Cys Glu Val Val 
    130                 135                 140                 


Lys Cys Leu Pro Val Thr Ala Pro Glu Asn Gly Lys Ile Val Ser Ser 
145                 150                 155                 160 


Ala Met Glu Pro Asp Arg Glu Tyr His Phe Gly Gln Ala Val Arg Phe 
                165                 170                 175     


Val Cys Asn Ser Gly Tyr Lys Ile Glu Gly Asp Glu Glu Met His Cys 
            180                 185                 190         


Ser Asp Asp Gly Phe Trp Ser Lys Glu Lys Pro Lys Cys Val Glu Ile 
        195                 200                 205             


Ser Cys Lys Ser Pro Asp Val Ile Asn Gly Ser Pro Ile Ser Gln Lys 
    210                 215                 220                 


Ile Ile Tyr Lys Glu Asn Glu Arg Phe Gln Tyr Lys Cys Asn Met Gly 
225                 230                 235                 240 


Tyr Glu Tyr Ser Glu Arg Gly Asp Ala Val Cys Thr Glu Ser Gly Trp 
                245                 250                 255     


Arg Pro Leu Pro Ser Cys Glu Glu Gly Gly Gly Gly Ser Arg Gly Gly 
            260                 265                 270         


Gly Gly Ser Gly Gly Gly Gly Ser Ile Val Gly Gly Lys Arg Ala Gln 
        275                 280                 285             


Leu Gly Asp Leu Pro Trp Gln Val Ala Ile Lys Asp Ala Ser Gly Ile 
    290                 295                 300                 


Thr Cys Gly Gly Ile Tyr Ile Gly Gly Cys Trp Ile Leu Thr Ala Ala 
305                 310                 315                 320 


His Cys Leu Arg Ala Ser Lys Thr His Arg Tyr Gln Ile Trp Thr Thr 
                325                 330                 335     


Val Val Asp Trp Ile His Pro Asp Leu Lys Arg Ile Val Ile Glu Tyr 
            340                 345                 350         


Val Asp Arg Ile Ile Phe His Glu Asn Tyr Asn Ala Gly Thr Tyr Gln 
        355                 360                 365             


Asn Asp Ile Ala Leu Ile Glu Met Lys Lys Asp Gly Asn Lys Lys Asp 
    370                 375                 380                 


Cys Glu Leu Pro Arg Ser Ile Pro Ala Ala Val Pro Trp Ser Pro Tyr 
385                 390                 395                 400 


Leu Phe Gln Pro Asn Asp Thr Cys Ile Val Ser Gly Trp Gly Arg Glu 
                405                 410                 415     


Lys Asp Asn Glu Arg Val Phe Ser Leu Gln Trp Gly Glu Val Lys Leu 
            420                 425                 430         


Ile Ser Asn Cys Ser Lys Phe Tyr Gly Asn Arg Phe Tyr Glu Lys Glu 
        435                 440                 445             


Met Glu Cys Ala Gly Thr Tyr Asp Gly Ser Ile Asp Ala Cys Lys Gly 
    450                 455                 460                 


Asp Ser Gly Gly Pro Leu Val Cys Met Asp Ala Asn Asn Val Thr Tyr 
465                 470                 475                 480 


Val Trp Gly Val Val Ser Trp Gly Glu Asn Cys Gly Lys Pro Glu Phe 
                485                 490                 495     


Pro Gly Val Tyr Thr Lys Val Ala Asn Tyr Phe Asp Trp Ile Ser Tyr 
            500                 505                 510         


His Val Gly Arg Pro Phe Ile Ser Gln Tyr Asn Val 
        515                 520                 


<210>  70
<211>  483
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glycosylated chimeric CR1a-FI protein amino acid sequence (with 
       signal peptide)

<400>  70

Met Arg Leu Leu Ala Lys Ile Ile Cys Leu Met Leu Trp Ala Ile Cys 
1               5                   10                  15      


Val Ala Gly His Cys Gln Ala Pro Asp His Phe Leu Phe Ala Lys Leu 
            20                  25                  30          


Lys Thr Gln Thr Asn Ala Ser Asp Phe Pro Ile Gly Thr Ser Leu Lys 
        35                  40                  45              


Tyr Glu Cys Arg Pro Glu Tyr Tyr Gly Arg Pro Phe Ser Ile Thr Cys 
    50                  55                  60                  


Leu Asp Asn Leu Val Trp Ser Ser Pro Lys Asp Val Cys Lys Arg Lys 
65                  70                  75                  80  


Ser Cys Lys Thr Pro Pro Asp Pro Val Asn Gly Met Val His Val Ile 
                85                  90                  95      


Thr Asp Ile Gln Val Gly Ser Arg Ile Asn Tyr Ser Cys Thr Thr Gly 
            100                 105                 110         


His Arg Leu Ile Gly His Ser Ser Ala Glu Cys Ile Leu Ser Gly Asn 
        115                 120                 125             


Ala Ala His Trp Ser Thr Lys Pro Pro Ile Cys Gln Arg Ile Pro Cys 
    130                 135                 140                 


Gly Leu Pro Pro Thr Ile Ala Asn Gly Asp Phe Ile Ser Thr Asn Arg 
145                 150                 155                 160 


Glu Asn Phe His Tyr Gly Ser Val Val Thr Tyr Arg Cys Asn Pro Gly 
                165                 170                 175     


Ser Gly Gly Arg Lys Val Phe Glu Leu Val Gly Glu Pro Ser Ile Tyr 
            180                 185                 190         


Cys Thr Ser Asn Asp Asp Gln Val Gly Ile Trp Ser Gly Pro Ala Pro 
        195                 200                 205             


Gln Cys Ile Ile Pro Asn Lys Ala Thr Pro Pro Asn Val Glu Asn Gly 
    210                 215                 220                 


Gly Gly Gly Ser Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ile 
225                 230                 235                 240 


Val Gly Gly Lys Arg Ala Gln Leu Gly Asp Leu Pro Trp Gln Val Ala 
                245                 250                 255     


Ile Lys Asp Ala Ser Gly Ile Thr Cys Gly Gly Ile Tyr Ile Gly Gly 
            260                 265                 270         


Cys Trp Ile Leu Thr Ala Ala His Cys Leu Arg Ala Ser Lys Thr His 
        275                 280                 285             


Arg Tyr Gln Ile Trp Thr Thr Val Val Asp Trp Ile His Pro Asp Leu 
    290                 295                 300                 


Lys Arg Ile Val Ile Glu Tyr Val Asp Arg Ile Ile Phe His Glu Asn 
305                 310                 315                 320 


Tyr Asn Ala Gly Thr Tyr Gln Asn Asp Ile Ala Leu Ile Glu Met Lys 
                325                 330                 335     


Lys Asp Gly Asn Lys Lys Asp Cys Glu Leu Pro Arg Ser Ile Pro Ala 
            340                 345                 350         


Ala Val Pro Trp Ser Pro Tyr Leu Phe Gln Pro Asn Asp Thr Cys Ile 
        355                 360                 365             


Val Ser Gly Trp Gly Arg Glu Lys Asp Asn Glu Arg Val Phe Ser Leu 
    370                 375                 380                 


Gln Trp Gly Glu Val Lys Leu Ile Ser Asn Cys Ser Lys Phe Tyr Gly 
385                 390                 395                 400 


Asn Arg Phe Tyr Glu Lys Glu Met Glu Cys Ala Gly Thr Tyr Asp Gly 
                405                 410                 415     


Ser Ile Asp Ala Cys Lys Gly Asp Ser Gly Gly Pro Leu Val Cys Met 
            420                 425                 430         


Asp Ala Asn Asn Val Thr Tyr Val Trp Gly Val Val Ser Trp Gly Glu 
        435                 440                 445             


Asn Cys Gly Lys Pro Glu Phe Pro Gly Val Tyr Thr Lys Val Ala Asn 
    450                 455                 460                 


Tyr Phe Asp Trp Ile Ser Tyr His Val Gly Arg Pro Phe Ile Ser Gln 
465                 470                 475                 480 


Tyr Asn Val 
            


<210>  71
<211>  483
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glycosylated chimeric CR1b-FI protein amino acid sequence (with 
       signal peptide)

<400>  71

Met Arg Leu Leu Ala Lys Ile Ile Cys Leu Met Leu Trp Ala Ile Cys 
1               5                   10                  15      


Val Ala Gly His Cys Gln Ala Pro Asp His Phe Leu Phe Ala Lys Leu 
            20                  25                  30          


Lys Thr Gln Thr Asn Ala Ser Asp Phe Pro Ile Gly Thr Ser Leu Lys 
        35                  40                  45              


Tyr Glu Cys Arg Pro Glu Tyr Tyr Gly Arg Pro Phe Ser Ile Thr Cys 
    50                  55                  60                  


Leu Asp Asn Leu Val Trp Ser Ser Pro Lys Asp Val Cys Lys Arg Lys 
65                  70                  75                  80  


Ser Cys Lys Thr Pro Pro Asp Pro Val Asn Gly Met Val His Val Ile 
                85                  90                  95      


Thr Asp Ile Gln Val Gly Ser Arg Ile Asn Tyr Ser Cys Thr Thr Gly 
            100                 105                 110         


His Arg Leu Ile Gly His Ser Ser Ala Glu Cys Ile Leu Ser Gly Asn 
        115                 120                 125             


Thr Ala His Trp Ser Thr Lys Pro Pro Ile Cys Gln Arg Ile Pro Cys 
    130                 135                 140                 


Gly Leu Pro Pro Thr Ile Ala Asn Gly Asp Phe Ile Ser Thr Asn Arg 
145                 150                 155                 160 


Glu Asn Phe His Tyr Gly Ser Val Val Thr Tyr Arg Cys Asn Leu Gly 
                165                 170                 175     


Ser Arg Gly Arg Lys Val Phe Glu Leu Val Gly Glu Pro Ser Ile Tyr 
            180                 185                 190         


Cys Thr Ser Asn Asp Asp Gln Val Gly Ile Trp Ser Gly Pro Ala Pro 
        195                 200                 205             


Gln Cys Ile Ile Pro Asn Lys Ala Thr Pro Pro Asn Val Glu Asn Gly 
    210                 215                 220                 


Gly Gly Gly Ser Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ile 
225                 230                 235                 240 


Val Gly Gly Lys Arg Ala Gln Leu Gly Asp Leu Pro Trp Gln Val Ala 
                245                 250                 255     


Ile Lys Asp Ala Ser Gly Ile Thr Cys Gly Gly Ile Tyr Ile Gly Gly 
            260                 265                 270         


Cys Trp Ile Leu Thr Ala Ala His Cys Leu Arg Ala Ser Lys Thr His 
        275                 280                 285             


Arg Tyr Gln Ile Trp Thr Thr Val Val Asp Trp Ile His Pro Asp Leu 
    290                 295                 300                 


Lys Arg Ile Val Ile Glu Tyr Val Asp Arg Ile Ile Phe His Glu Asn 
305                 310                 315                 320 


Tyr Asn Ala Gly Thr Tyr Gln Asn Asp Ile Ala Leu Ile Glu Met Lys 
                325                 330                 335     


Lys Asp Gly Asn Lys Lys Asp Cys Glu Leu Pro Arg Ser Ile Pro Ala 
            340                 345                 350         


Ala Val Pro Trp Ser Pro Tyr Leu Phe Gln Pro Asn Asp Thr Cys Ile 
        355                 360                 365             


Val Ser Gly Trp Gly Arg Glu Lys Asp Asn Glu Arg Val Phe Ser Leu 
    370                 375                 380                 


Gln Trp Gly Glu Val Lys Leu Ile Ser Asn Cys Ser Lys Phe Tyr Gly 
385                 390                 395                 400 


Asn Arg Phe Tyr Glu Lys Glu Met Glu Cys Ala Gly Thr Tyr Asp Gly 
                405                 410                 415     


Ser Ile Asp Ala Cys Lys Gly Asp Ser Gly Gly Pro Leu Val Cys Met 
            420                 425                 430         


Asp Ala Asn Asn Val Thr Tyr Val Trp Gly Val Val Ser Trp Gly Glu 
        435                 440                 445             


Asn Cys Gly Lys Pro Glu Phe Pro Gly Val Tyr Thr Lys Val Ala Asn 
    450                 455                 460                 


Tyr Phe Asp Trp Ile Ser Tyr His Val Gly Arg Pro Phe Ile Ser Gln 
465                 470                 475                 480 


Tyr Asn Val 
            


<210>  72
<211>  483
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  non-glycosylated chimeric CR1a-FI protein amino acid sequence 
       (with signal peptide)

<400>  72

Met Arg Leu Leu Ala Lys Ile Ile Cys Leu Met Leu Trp Ala Ile Cys 
1               5                   10                  15      


Val Ala Gly His Cys Gln Ala Pro Asp His Phe Leu Phe Ala Lys Leu 
            20                  25                  30          


Lys Thr Gln Thr Gln Ala Ser Asp Phe Pro Ile Gly Thr Ser Leu Lys 
        35                  40                  45              


Tyr Glu Cys Arg Pro Glu Tyr Tyr Gly Arg Pro Phe Ser Ile Thr Cys 
    50                  55                  60                  


Leu Asp Asn Leu Val Trp Ser Ser Pro Lys Asp Val Cys Lys Arg Lys 
65                  70                  75                  80  


Ser Cys Lys Thr Pro Pro Asp Pro Val Asn Gly Met Val His Val Ile 
                85                  90                  95      


Thr Asp Ile Gln Val Gly Ser Arg Ile Gln Tyr Ser Cys Thr Thr Gly 
            100                 105                 110         


His Arg Leu Ile Gly His Ser Ser Ala Glu Cys Ile Leu Ser Gly Asn 
        115                 120                 125             


Ala Ala His Trp Ser Thr Lys Pro Pro Ile Cys Gln Arg Ile Pro Cys 
    130                 135                 140                 


Gly Leu Pro Pro Thr Ile Ala Asn Gly Asp Phe Ile Ser Thr Asn Arg 
145                 150                 155                 160 


Glu Asn Phe His Tyr Gly Ser Val Val Thr Tyr Arg Cys Asn Pro Gly 
                165                 170                 175     


Ser Gly Gly Arg Lys Val Phe Glu Leu Val Gly Glu Pro Ser Ile Tyr 
            180                 185                 190         


Cys Thr Ser Asn Asp Asp Gln Val Gly Ile Trp Ser Gly Pro Ala Pro 
        195                 200                 205             


Gln Cys Ile Ile Pro Asn Lys Ala Thr Pro Pro Asn Val Glu Asn Gly 
    210                 215                 220                 


Gly Gly Gly Ser Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ile 
225                 230                 235                 240 


Val Gly Gly Lys Arg Ala Gln Leu Gly Asp Leu Pro Trp Gln Val Ala 
                245                 250                 255     


Ile Lys Asp Ala Ser Gly Ile Thr Cys Gly Gly Ile Tyr Ile Gly Gly 
            260                 265                 270         


Cys Trp Ile Leu Thr Ala Ala His Cys Leu Arg Ala Ser Lys Thr His 
        275                 280                 285             


Arg Tyr Gln Ile Trp Thr Thr Val Val Asp Trp Ile His Pro Asp Leu 
    290                 295                 300                 


Lys Arg Ile Val Ile Glu Tyr Val Asp Arg Ile Ile Phe His Glu Asn 
305                 310                 315                 320 


Tyr Asn Ala Gly Thr Tyr Gln Asn Asp Ile Ala Leu Ile Glu Met Lys 
                325                 330                 335     


Lys Asp Gly Asn Lys Lys Asp Cys Glu Leu Pro Arg Ser Ile Pro Ala 
            340                 345                 350         


Ala Val Pro Trp Ser Pro Tyr Leu Phe Gln Pro Gln Asp Thr Cys Ile 
        355                 360                 365             


Val Ser Gly Trp Gly Arg Glu Lys Asp Asn Glu Arg Val Phe Ser Leu 
    370                 375                 380                 


Gln Trp Gly Glu Val Lys Leu Ile Ser Gln Cys Ser Lys Phe Tyr Gly 
385                 390                 395                 400 


Asn Arg Phe Tyr Glu Lys Glu Met Glu Cys Ala Gly Thr Tyr Asp Gly 
                405                 410                 415     


Ser Ile Asp Ala Cys Lys Gly Asp Ser Gly Gly Pro Leu Val Cys Met 
            420                 425                 430         


Asp Ala Asn Gln Val Thr Tyr Val Trp Gly Val Val Ser Trp Gly Glu 
        435                 440                 445             


Asn Cys Gly Lys Pro Glu Phe Pro Gly Val Tyr Thr Lys Val Ala Asn 
    450                 455                 460                 


Tyr Phe Asp Trp Ile Ser Tyr His Val Gly Arg Pro Phe Ile Ser Gln 
465                 470                 475                 480 


Tyr Asn Val 
            


<210>  73
<211>  483
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  non-glycosylated chimeric CR1b-FI protein amino acid sequence 
       (with signal peptide)

<400>  73

Met Arg Leu Leu Ala Lys Ile Ile Cys Leu Met Leu Trp Ala Ile Cys 
1               5                   10                  15      


Val Ala Gly His Cys Gln Ala Pro Asp His Phe Leu Phe Ala Lys Leu 
            20                  25                  30          


Lys Thr Gln Thr Gln Ala Ser Asp Phe Pro Ile Gly Thr Ser Leu Lys 
        35                  40                  45              


Tyr Glu Cys Arg Pro Glu Tyr Tyr Gly Arg Pro Phe Ser Ile Thr Cys 
    50                  55                  60                  


Leu Asp Asn Leu Val Trp Ser Ser Pro Lys Asp Val Cys Lys Arg Lys 
65                  70                  75                  80  


Ser Cys Lys Thr Pro Pro Asp Pro Val Asn Gly Met Val His Val Ile 
                85                  90                  95      


Thr Asp Ile Gln Val Gly Ser Arg Ile Gln Tyr Ser Cys Thr Thr Gly 
            100                 105                 110         


His Arg Leu Ile Gly His Ser Ser Ala Glu Cys Ile Leu Ser Gly Asn 
        115                 120                 125             


Ala Ala His Trp Ser Thr Lys Pro Pro Ile Cys Gln Arg Ile Pro Cys 
    130                 135                 140                 


Gly Leu Pro Pro Thr Ile Ala Asn Gly Asp Phe Ile Ser Thr Asn Arg 
145                 150                 155                 160 


Glu Asn Phe His Tyr Gly Ser Val Val Thr Tyr Arg Cys Asn Pro Gly 
                165                 170                 175     


Ser Gly Gly Arg Lys Val Phe Glu Leu Val Gly Glu Pro Ser Ile Tyr 
            180                 185                 190         


Cys Thr Ser Asn Asp Asp Gln Val Gly Ile Trp Ser Gly Pro Ala Pro 
        195                 200                 205             


Gln Cys Ile Ile Pro Asn Lys Ala Thr Pro Pro Asn Val Glu Asn Gly 
    210                 215                 220                 


Gly Gly Gly Ser Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ile 
225                 230                 235                 240 


Val Gly Gly Lys Arg Ala Gln Leu Gly Asp Leu Pro Trp Gln Val Ala 
                245                 250                 255     


Ile Lys Asp Ala Ser Gly Ile Thr Cys Gly Gly Ile Tyr Ile Gly Gly 
            260                 265                 270         


Cys Trp Ile Leu Thr Ala Ala His Cys Leu Arg Ala Ser Lys Thr His 
        275                 280                 285             


Arg Tyr Gln Ile Trp Thr Thr Val Val Asp Trp Ile His Pro Asp Leu 
    290                 295                 300                 


Lys Arg Ile Val Ile Glu Tyr Val Asp Arg Ile Ile Phe His Glu Asn 
305                 310                 315                 320 


Tyr Asn Ala Gly Thr Tyr Gln Asn Asp Ile Ala Leu Ile Glu Met Lys 
                325                 330                 335     


Lys Asp Gly Asn Lys Lys Asp Cys Glu Leu Pro Arg Ser Ile Pro Ala 
            340                 345                 350         


Ala Val Pro Trp Ser Pro Tyr Leu Phe Gln Pro Gln Asp Thr Cys Ile 
        355                 360                 365             


Val Ser Gly Trp Gly Arg Glu Lys Asp Asn Glu Arg Val Phe Ser Leu 
    370                 375                 380                 


Gln Trp Gly Glu Val Lys Leu Ile Ser Gln Cys Ser Lys Phe Tyr Gly 
385                 390                 395                 400 


Asn Arg Phe Tyr Glu Lys Glu Met Glu Cys Ala Gly Thr Tyr Asp Gly 
                405                 410                 415     


Ser Ile Asp Ala Cys Lys Gly Asp Ser Gly Gly Pro Leu Val Cys Met 
            420                 425                 430         


Asp Ala Asn Gln Val Thr Tyr Val Trp Gly Val Val Ser Trp Gly Glu 
        435                 440                 445             


Asn Cys Gly Lys Pro Glu Phe Pro Gly Val Tyr Thr Lys Val Ala Asn 
    450                 455                 460                 


Tyr Phe Asp Trp Ile Ser Tyr His Val Gly Arg Pro Phe Ile Ser Gln 
465                 470                 475                 480 


Tyr Asn Val 
            


