                         SEQUENCE LISTING

<110>  GEMoaB Monoclonals GmbH
 
<120>  Targeting modules for universal chimeric antigen receptor 
       expressing immune cells and use in the treatment of cancer, 
       infections and autoimmune disorders

<130>  01281P0013EPWO

<150>  EP17 175 124.1
<151>  2017-06-09

<160>  27    

<170>  PatentIn version 3.5

<210>  1
<211>  1806
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Homo sapiens/Mus musculus chimera

<400>  1
atgcgccgca tgcagctgct gcttctgatc gctctgagcc tggctcttgt gaccaactct       60

gaattccagg tgcagctggt gcagagcgga gccgaggtga agaagcctgg agcctctgtg      120

aaggtgagct gcaaggcttc tggctacacc ttcacccact actacatcta ctgggtgaga      180

caggctcccg gacagggcct ggagtggatg ggaggcgtga accccagcaa cggaggcacc      240

cacttcaacg agaagttcaa gtctcgcgtg accatgaccc gcgacaccag catctctacc      300

gcttacatgg agctgagccg cctgcgctct gatgataccg ctgtgtacta ctgcgctcgc      360

agcgagtacg attacggact gggcttcgcc tactggggcc agggaaccct ggtgaccgtg      420

agctctggag gcggaggcag cggaggcggc ggatctggag gcggaggaag cgatatcgtg      480

atgacccagt ctcctgatag cctggctgtg agcctgggcg agagagctac catcaactgc      540

aagagcagcc agagcctgct gaactctcgc acccctaaga actaccttgc ttggtaccag      600

cagaagcctg gacagccccc taagctgctg atctactggg cttctacccg caagagcggc      660

gtgcccgaca gattctctgg cagcggaagc ggcaccgatt tcaccctgac catcagcagc      720

ctgcaggctg aggacgtggc cgtgtactac tgcaagcagt cttacaacct gctgaccttc      780

ggaggcggaa ccaaggtgga gatcaaggct gccgctggag gaggcggcag caagatcctg      840

gtcaaacagt cccctatgct ggtcgcttac gacaacgccg ttaatctgag ttgcaaatat      900

agttacaacc tgtttagccg ggaatttcgc gcatctctcc acaagggact ggattctgcg      960

gttgaggttt gtgtggtcta tggcaattat agccagcaac tgcaagtgta cagcaaaaca     1020

ggctttaact gcgacgggaa actcgggaac gaatcagtga ccttctatct gcagaacctg     1080

tacgttaacc aaacagatat ttacttctgc aagatagagg tgatggctcc accgccagca     1140

ctggataacg agaagtccaa tggaaccatc attcacgtca aggggaagca tctgtgtcct     1200

tccccgttgt tccctgggcc gagcaaaccc ttttgggtgc ttgtggtagt tggcggggta     1260

ttggcctgct attcccttct cgtaactgtg gccttcatca tcttctgggt cagatctaag     1320

aggtctaggg gcgggcatag cgactacatg aacatgacac ccaggcggcc tggccccact     1380

cgcaaacact accagccata cgcaccacca agagactttg ccgcatatcg gagtggtggc     1440

ggcgggtcag gaggtggagc tagcggtgga ggaggttcct tctctaggtc agctgatgct     1500

cccgcctatc agcaaggtca gaaccagctc tacaatgagc tgaatctggg acgtcgggag     1560

gagtacgacg tgctggataa acgaagagga cgcgatcccg agatgggtgg gaagcctagg     1620

cgcaagaatc cccaggaagg cctctacaat gaactgcaga aagacaagat ggccgaagcc     1680

tacagcgaga ttggcatgaa aggggagcga cggagaggaa agggacatga cgggttgtat     1740

cagggtcttt ccactgcgac aaaggatacc tatggggctc tgcacatgca agcactgcca     1800

cctaga                                                                1806


<210>  2
<211>  60
<212>  DNA
<213>  Homo sapiens

<400>  2
atgcgccgca tgcagctgct gcttctgatc gctctgagcc tggctcttgt gaccaactct       60


<210>  3
<211>  360
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Homo sapiens/Mus musculus chimera

<400>  3
caggtgcagc tggtgcagag cggagccgag gtgaagaagc ctggagcctc tgtgaaggtg       60

agctgcaagg cttctggcta caccttcacc cactactaca tctactgggt gagacaggct      120

cccggacagg gcctggagtg gatgggaggc gtgaacccca gcaacggagg cacccacttc      180

aacgagaagt tcaagtctcg cgtgaccatg acccgcgaca ccagcatctc taccgcttac      240

atggagctga gccgcctgcg ctctgatgat accgctgtgt actactgcgc tcgcagcgag      300

tacgattacg gactgggctt cgcctactgg ggccagggaa ccctggtgac cgtgagctct      360


<210>  4
<211>  336
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Homo sapiens/Mus musculus chimera

<400>  4
gatatcgtga tgacccagtc tcctgatagc ctggctgtga gcctgggcga gagagctacc       60

atcaactgca agagcagcca gagcctgctg aactctcgca cccctaagaa ctaccttgct      120

tggtaccagc agaagcctgg acagccccct aagctgctga tctactgggc ttctacccgc      180

aagagcggcg tgcccgacag attctctggc agcggaagcg gcaccgattt caccctgacc      240

atcagcagcc tgcaggctga ggacgtggcc gtgtactact gcaagcagtc ttacaacctg      300

ctgaccttcg gaggcggaac caaggtggag atcaag                                336


<210>  5
<211>  399
<212>  DNA
<213>  Homo sapiens

<400>  5
aagatcctgg tcaaacagtc ccctatgctg gtcgcttacg acaacgccgt taatctgagt       60

tgcaaatata gttacaacct gtttagccgg gaatttcgcg catctctcca caagggactg      120

gattctgcgg ttgaggtttg tgtggtctat ggcaattata gccagcaact gcaagtgtac      180

agcaaaacag gctttaactg cgacgggaaa ctcgggaacg aatcagtgac cttctatctg      240

cagaacctgt acgttaacca aacagatatt tacttctgca agatagaggt gatggctcca      300

ccgccagcac tggataacga gaagtccaat ggaaccatca ttcacgtcaa ggggaagcat      360

ctgtgtcctt ccccgttgtt ccctgggccg agcaaaccc                             399


<210>  6
<211>  81
<212>  DNA
<213>  Homo sapiens

<400>  6
ttttgggtgc ttgtggtagt tggcggggta ttggcctgct attcccttct cgtaactgtg       60

gccttcatca tcttctgggt c                                                 81


<210>  7
<211>  123
<212>  DNA
<213>  Homo sapiens

<400>  7
agatctaaga ggtctagggg cgggcatagc gactacatga acatgacacc caggcggcct       60

ggccccactc gcaaacacta ccagccatac gcaccaccaa gagactttgc cgcatatcgg      120

agt                                                                    123


<210>  8
<211>  327
<212>  DNA
<213>  Homo sapiens

<400>  8
ttctctaggt cagctgatgc tcccgcctat cagcaaggtc agaaccagct ctacaatgag       60

ctgaatctgg gacgtcggga ggagtacgac gtgctggata aacgaagagg acgcgatccc      120

gagatgggtg ggaagcctag gcgcaagaat ccccaggaag gcctctacaa tgaactgcag      180

aaagacaaga tggccgaagc ctacagcgag attggcatga aaggggagcg acggagagga      240

aagggacatg acgggttgta tcagggtctt tccactgcga caaaggatac ctatggggct      300

ctgcacatgc aagcactgcc acctaga                                          327


<210>  9
<211>  1512
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Homo sapiens/Mus musculus chimera

<400>  9
atgcgccgca tgcagctgct gcttctgatc gctctgagcc tggctcttgt gaccaactct       60

gaattccagg tgcagctggt gcagagcgga gccgaggtga agaagcctgg agcctctgtg      120

aaggtgagct gcaaggcttc tggctacacc ttcacccact actacatcta ctgggtgaga      180

caggctcccg gacagggcct ggagtggatg ggaggcgtga accccagcaa cggaggcacc      240

cacttcaacg agaagttcaa gtctcgcgtg accatgaccc gcgacaccag catctctacc      300

gcttacatgg agctgagccg cctgcgctct gatgataccg ctgtgtacta ctgcgctcgc      360

agcgagtacg attacggact gggcttcgcc tactggggcc agggaaccct ggtgaccgtg      420

agctctggag gcggaggcag cggaggcggc ggatctggag gcggaggaag cgatatcgtg      480

atgacccagt ctcctgatag cctggctgtg agcctgggcg agagagctac catcaactgc      540

aagagcagcc agagcctgct gaactctcgc acccctaaga actaccttgc ttggtaccag      600

cagaagcctg gacagccccc taagctgctg atctactggg cttctacccg caagagcggc      660

gtgcccgaca gattctctgg cagcggaagc ggcaccgatt tcaccctgac catcagcagc      720

ctgcaggctg aggacgtggc cgtgtactac tgcaagcagt cttacaacct gctgaccttc      780

ggaggcggaa ccaaggtgga gatcaaggga ggaggcgggt caaccactac ccctgctccc      840

aggcctccta cacccgcgcc aacgattgcc agtcaacctc tgtccctgag gcctgaagcc      900

tgcagaccag ctgcaggcgg tgctgtgcat acacggggct tggactttgc ctgcgatatc      960

tacatctggg cacctcttgc cgggacttgt ggcgttctcc tgctttctct ggtcattacc     1020

ctgtactgtg gaggcggcgg tagcaaacgc ggacggaaga aactgctgta catcttcaag     1080

cagcccttca tgcgccccgt gcagacaaca caggaagagg acggttgcag ctgccgattt     1140

cccgaagagg aggagggagg ctgtgaattg ggcggaggag gctccttctc tcgcagtgca     1200

gatgccccag cgtacaagca aggccagaac cagctgtaca acgagctcaa tctggggcgt     1260

agagaggagt atgacgtgct ggacaagagg cgaggaaggg accccgagat gggtggcaaa     1320

ccgcggcgta agaatccgca ggaaggcctc tacaacgagc tgcagaaaga caagatggcc     1380

gaagcctatt ccgagatagg gatgaaaggg gaaagacggc gcggtaaagg gcacgatggg     1440

ctctatcagg gtctgagcac tgcaaccaag gacacgtatg atgccttgca catgcaagct     1500

cttccaccaa ga                                                         1512


<210>  10
<211>  135
<212>  DNA
<213>  Homo sapiens

<400>  10
accactaccc ctgctcccag gcctcctaca cccgcgccaa cgattgccag tcaacctctg       60

tccctgaggc ctgaagcctg cagaccagct gcaggcggtg ctgtgcatac acggggcttg      120

gactttgcct gcgat                                                       135


<210>  11
<211>  72
<212>  DNA
<213>  Homo sapiens

<400>  11
atctacatct gggcacctct tgccgggact tgtggcgttc tcctgctttc tctggtcatt       60

accctgtact gt                                                           72


<210>  12
<211>  126
<212>  DNA
<213>  Homo sapiens

<400>  12
aaacgcggac ggaagaaact gctgtacatc ttcaagcagc ccttcatgcg ccccgtgcag       60

acaacacagg aagaggacgg ttgcagctgc cgatttcccg aagaggagga gggaggctgt      120

gaattg                                                                 126


<210>  13
<211>  1806
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Homo sapiens/Mus musculus chimera

<400>  13
atgcgccgca tgcagctgct gcttctgatc gctctgagcc tggctcttgt gaccaactct       60

gaattccagg tggaggtgca actggtcgaa agtggcggtg gtttagttca gcctggtgga      120

agtctacggc ttagctgcgc agcatccggt ttcaccttta gcgacttttg gatgaactgg      180

gttcggcagg ctccgggcaa aggactggag tgggttgggc aaatccgcaa caaaccgaat      240

aactacgaaa cttattactc agatagcctg aagggtcgat tcaccatcag cagggatgat      300

tcaaagtcaa tcacttacct acagatgaac tcattaagag cggaggatac tgcggtgtat      360

tactgtacac taggtaactc ctggttcgcg tattggggac agggcaccct tgtaaccgtc      420

tccagcggag gcggaggcag cggaggcggc ggatctggag gcggaggaag cgacattgtt      480

atgacccaga gcccggactc tctcgctgtt agtcttggtg agcgagcgac tattaactgc      540

cggagcagtc agagtttgtt ggactctcgg acgaaaaaga actacctggc atggtaccag      600

cagaagccgg gccaaccacc taaattactg atatattggg cgtcgactcg tgagtcaggg      660

gtaccggaca ggttttctgg aagcggatca ggaacagact tcactttgac gatctcttcg      720

cttcaagccg aggacgttgc ggtttattat tgtaagcaaa gctataatct gccgacattt      780

ggtggcggca ccaaggttga aattaaggct gccgctggag gaggcggcag caagatcctg      840

gtcaaacagt cccctatgct ggtcgcttac gacaacgccg ttaatctgag ttgcaaatat      900

agttacaacc tgtttagccg ggaatttcgc gcatctctcc acaagggact ggattctgcg      960

gttgaggttt gtgtggtcta tggcaattat agccagcaac tgcaagtgta cagcaaaaca     1020

ggctttaact gcgacgggaa actcgggaac gaatcagtga ccttctatct gcagaacctg     1080

tacgttaacc aaacagatat ttacttctgc aagatagagg tgatggctcc accgccagca     1140

ctggataacg agaagtccaa tggaaccatc attcacgtca aggggaagca tctgtgtcct     1200

tccccgttgt tccctgggcc gagcaaaccc ttttgggtgc ttgtggtagt tggcggggta     1260

ttggcctgct attcccttct cgtaactgtg gccttcatca tcttctgggt cagatctaag     1320

aggtctaggg gcgggcatag cgactacatg aacatgacac ccaggcggcc tggccccact     1380

cgcaaacact accagccata cgcaccacca agagactttg ccgcatatcg gagtggtggc     1440

ggcgggtcag gaggtggagc tagcggtgga ggaggttcct tctctaggtc agctgatgct     1500

cccgcctatc agcaaggtca gaaccagctc tacaatgagc tgaatctggg acgtcgggag     1560

gagtacgacg tgctggataa acgaagagga cgcgatcccg agatgggtgg gaagcctagg     1620

cgcaagaatc cccaggaagg cctctacaat gaactgcaga aagacaagat ggccgaagcc     1680

tacagcgaga ttggcatgaa aggggagcga cggagaggaa agggacatga cgggttgtat     1740

cagggtcttt ccactgcgac aaaggatacc tatggggctc tgcacatgca agcactgcca     1800

cctaga                                                                1806


<210>  14
<211>  354
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Homo sapiens/Mus musculus chimera

<400>  14
gaggtgcaac tggtcgaaag tggcggtggt ttagttcagc ctggtggaag tctacggctt       60

agctgcgcag catccggttt cacctttagc gacttttgga tgaactgggt tcggcaggct      120

ccgggcaaag gactggagtg ggttgggcaa atccgcaaca aaccgaataa ctacgaaact      180

tattactcag atagcctgaa gggtcgattc accatcagca gggatgattc aaagtcaatc      240

acttacctac agatgaactc attaagagcg gaggatactg cggtgtatta ctgtacacta      300

ggtaactcct ggttcgcgta ttggggacag ggcacccttg taaccgtctc cagc            354


<210>  15
<211>  336
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Homo sapiens/Mus musculus chimera

<400>  15
gacattgtta tgacccagag cccggactct ctcgctgtta gtcttggtga gcgagcgact       60

attaactgcc ggagcagtca gagtttgttg gactctcgga cgaaaaagaa ctacctggca      120

tggtaccagc agaagccggg ccaaccacct aaattactga tatattgggc gtcgactcgt      180

gagtcagggg taccggacag gttttctgga agcggatcag gaacagactt cactttgacg      240

atctcttcgc ttcaagccga ggacgttgcg gtttattatt gtaagcaaag ctataatctg      300

ccgacatttg gtggcggcac caaggttgaa attaag                                336


<210>  16
<211>  1506
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Homo sapiens/Mus musculus chimera

<400>  16
atgcgccgca tgcagctgct gcttctgatc gctctgagcc tggctcttgt gaccaactct       60

gaattcgagg tgcaactggt cgaaagtggc ggtggtttag ttcagcctgg tggaagtcta      120

cggcttagct gcgcagcatc cggtttcacc tttagcgact tttggatgaa ctgggttcgg      180

caggctccgg gcaaaggact ggagtgggtt gggcaaatcc gcaacaaacc gaataactac      240

gaaacttatt actcagatag cctgaagggt cgattcacca tcagcaggga tgattcaaag      300

tcaatcactt acctacagat gaactcatta agagcggagg atactgcggt gtattactgt      360

acactaggta actcctggtt cgcgtattgg ggacagggca cccttgtaac cgtctccagc      420

ggaggcggag gcagcggagg cggcggatct ggaggcggag gaagcgacat tgttatgacc      480

cagagcccgg actctctcgc tgttagtctt ggtgagcgag cgactattaa ctgccggagc      540

agtcagagtt tgttggactc tcggacgaaa aagaactacc tggcatggta ccagcagaag      600

ccgggccaac cacctaaatt actgatatat tgggcgtcga ctcgtgagtc aggggtaccg      660

gacaggtttt ctggaagcgg atcaggaaca gacttcactt tgacgatctc ttcgcttcaa      720

gccgaggacg ttgcggttta ttattgtaag caaagctata atctgccgac atttggtggc      780

ggcaccaagg ttgaaattaa gggaggaggc gggtcaacca ctacccctgc tcccaggcct      840

cctacacccg cgccaacgat tgccagtcaa cctctgtccc tgaggcctga agcctgcaga      900

ccagctgcag gcggtgctgt gcatacacgg ggcttggact ttgcctgcga tatctacatc      960

tgggcacctc ttgccgggac ttgtggcgtt ctcctgcttt ctctggtcat taccctgtac     1020

tgtggaggcg gcggtagcaa acgcggacgg aagaaactgc tgtacatctt caagcagccc     1080

ttcatgcgcc ccgtgcagac aacacaggaa gaggacggtt gcagctgccg atttcccgaa     1140

gaggaggagg gaggctgtga attgggcgga ggaggctcct tctctcgcag tgcagatgcc     1200

ccagcgtaca agcaaggcca gaaccagctg tacaacgagc tcaatctggg gcgtagagag     1260

gagtatgacg tgctggacaa gaggcgagga agggaccccg agatgggtgg caaaccgcgg     1320

cgtaagaatc cgcaggaagg cctctacaac gagctgcaga aagacaagat ggccgaagcc     1380

tattccgaga tagggatgaa aggggaaaga cggcgcggta aagggcacga tgggctctat     1440

cagggtctga gcactgcaac caaggacacg tatgatgcct tgcacatgca agctcttcca     1500

ccaaga                                                                1506


<210>  17
<211>  602
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Homo sapiens/Mus musculus chimera

<400>  17

Met Arg Arg Met Gln Leu Leu Leu Leu Ile Ala Leu Ser Leu Ala Leu 
1               5                   10                  15      


Val Thr Asn Ser Glu Phe Gln Val Gln Leu Val Gln Ser Gly Ala Glu 
            20                  25                  30          


Val Lys Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly 
        35                  40                  45              


Tyr Thr Phe Thr His Tyr Tyr Ile Tyr Trp Val Arg Gln Ala Pro Gly 
    50                  55                  60                  


Gln Gly Leu Glu Trp Met Gly Gly Val Asn Pro Ser Asn Gly Gly Thr 
65                  70                  75                  80  


His Phe Asn Glu Lys Phe Lys Ser Arg Val Thr Met Thr Arg Asp Thr 
                85                  90                  95      


Ser Ile Ser Thr Ala Tyr Met Glu Leu Ser Arg Leu Arg Ser Asp Asp 
            100                 105                 110         


Thr Ala Val Tyr Tyr Cys Ala Arg Ser Glu Tyr Asp Tyr Gly Leu Gly 
        115                 120                 125             


Phe Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val 
145                 150                 155                 160 


Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly Glu Arg Ala 
                165                 170                 175     


Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser Arg Thr Pro 
            180                 185                 190         


Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys 
        195                 200                 205             


Leu Leu Ile Tyr Trp Ala Ser Thr Arg Lys Ser Gly Val Pro Asp Arg 
    210                 215                 220                 


Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser 
225                 230                 235                 240 


Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Lys Gln Ser Tyr Asn 
                245                 250                 255     


Leu Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Ala Ala Ala 
            260                 265                 270         


Gly Gly Gly Gly Ser Lys Ile Leu Val Lys Gln Ser Pro Met Leu Val 
        275                 280                 285             


Ala Tyr Asp Asn Ala Val Asn Leu Ser Cys Lys Tyr Ser Tyr Asn Leu 
    290                 295                 300                 


Phe Ser Arg Glu Phe Arg Ala Ser Leu His Lys Gly Leu Asp Ser Ala 
305                 310                 315                 320 


Val Glu Val Cys Val Val Tyr Gly Asn Tyr Ser Gln Gln Leu Gln Val 
                325                 330                 335     


Tyr Ser Lys Thr Gly Phe Asn Cys Asp Gly Lys Leu Gly Asn Glu Ser 
            340                 345                 350         


Val Thr Phe Tyr Leu Gln Asn Leu Tyr Val Asn Gln Thr Asp Ile Tyr 
        355                 360                 365             


Phe Cys Lys Ile Glu Val Met Ala Pro Pro Pro Ala Leu Asp Asn Glu 
    370                 375                 380                 


Lys Ser Asn Gly Thr Ile Ile His Val Lys Gly Lys His Leu Cys Pro 
385                 390                 395                 400 


Ser Pro Leu Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val 
                405                 410                 415     


Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe 
            420                 425                 430         


Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg Gly Gly His Ser Asp 
        435                 440                 445             


Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr 
    450                 455                 460                 


Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Gly Gly 
465                 470                 475                 480 


Gly Gly Ser Gly Gly Gly Ala Ser Gly Gly Gly Gly Ser Phe Ser Arg 
                485                 490                 495     


Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn 
            500                 505                 510         


Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg 
        515                 520                 525             


Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro 
    530                 535                 540                 


Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala 
545                 550                 555                 560 


Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His 
                565                 570                 575     


Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Gly 
            580                 585                 590         


Ala Leu His Met Gln Ala Leu Pro Pro Arg 
        595                 600         


<210>  18
<211>  504
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Homo sapiens/Mus musculus chimera

<400>  18

Met Arg Arg Met Gln Leu Leu Leu Leu Ile Ala Leu Ser Leu Ala Leu 
1               5                   10                  15      


Val Thr Asn Ser Glu Phe Gln Val Gln Leu Val Gln Ser Gly Ala Glu 
            20                  25                  30          


Val Lys Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly 
        35                  40                  45              


Tyr Thr Phe Thr His Tyr Tyr Ile Tyr Trp Val Arg Gln Ala Pro Gly 
    50                  55                  60                  


Gln Gly Leu Glu Trp Met Gly Gly Val Asn Pro Ser Asn Gly Gly Thr 
65                  70                  75                  80  


His Phe Asn Glu Lys Phe Lys Ser Arg Val Thr Met Thr Arg Asp Thr 
                85                  90                  95      


Ser Ile Ser Thr Ala Tyr Met Glu Leu Ser Arg Leu Arg Ser Asp Asp 
            100                 105                 110         


Thr Ala Val Tyr Tyr Cys Ala Arg Ser Glu Tyr Asp Tyr Gly Leu Gly 
        115                 120                 125             


Phe Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val 
145                 150                 155                 160 


Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly Glu Arg Ala 
                165                 170                 175     


Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser Arg Thr Pro 
            180                 185                 190         


Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys 
        195                 200                 205             


Leu Leu Ile Tyr Trp Ala Ser Thr Arg Lys Ser Gly Val Pro Asp Arg 
    210                 215                 220                 


Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser 
225                 230                 235                 240 


Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Lys Gln Ser Tyr Asn 
                245                 250                 255     


Leu Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Gly Gly Gly 
            260                 265                 270         


Gly Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr 
        275                 280                 285             


Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala 
    290                 295                 300                 


Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile 
305                 310                 315                 320 


Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser 
                325                 330                 335     


Leu Val Ile Thr Leu Tyr Cys Gly Gly Gly Gly Ser Lys Arg Gly Arg 
            340                 345                 350         


Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln 
        355                 360                 365             


Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu 
    370                 375                 380                 


Glu Gly Gly Cys Glu Leu Gly Gly Gly Gly Ser Phe Ser Arg Ser Ala 
385                 390                 395                 400 


Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu 
                405                 410                 415     


Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly 
            420                 425                 430         


Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu 
        435                 440                 445             


Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser 
    450                 455                 460                 


Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly 
465                 470                 475                 480 


Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu 
                485                 490                 495     


His Met Gln Ala Leu Pro Pro Arg 
            500                 


<210>  19
<211>  602
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Homo sapiens/Mus musculus chimera

<400>  19

Met Arg Arg Met Gln Leu Leu Leu Leu Ile Ala Leu Ser Leu Ala Leu 
1               5                   10                  15      


Val Thr Asn Ser Glu Phe Gln Val Glu Val Gln Leu Val Glu Ser Gly 
            20                  25                  30          


Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala 
        35                  40                  45              


Ser Gly Phe Thr Phe Ser Asp Phe Trp Met Asn Trp Val Arg Gln Ala 
    50                  55                  60                  


Pro Gly Lys Gly Leu Glu Trp Val Gly Gln Ile Arg Asn Lys Pro Asn 
65                  70                  75                  80  


Asn Tyr Glu Thr Tyr Tyr Ser Asp Ser Leu Lys Gly Arg Phe Thr Ile 
                85                  90                  95      


Ser Arg Asp Asp Ser Lys Ser Ile Thr Tyr Leu Gln Met Asn Ser Leu 
            100                 105                 110         


Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Thr Leu Gly Asn Ser Trp 
        115                 120                 125             


Phe Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val 
145                 150                 155                 160 


Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly Glu Arg Ala 
                165                 170                 175     


Thr Ile Asn Cys Arg Ser Ser Gln Ser Leu Leu Asp Ser Arg Thr Lys 
            180                 185                 190         


Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys 
        195                 200                 205             


Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val Pro Asp Arg 
    210                 215                 220                 


Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser 
225                 230                 235                 240 


Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Lys Gln Ser Tyr Asn 
                245                 250                 255     


Leu Pro Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Ala Ala Ala 
            260                 265                 270         


Gly Gly Gly Gly Ser Lys Ile Leu Val Lys Gln Ser Pro Met Leu Val 
        275                 280                 285             


Ala Tyr Asp Asn Ala Val Asn Leu Ser Cys Lys Tyr Ser Tyr Asn Leu 
    290                 295                 300                 


Phe Ser Arg Glu Phe Arg Ala Ser Leu His Lys Gly Leu Asp Ser Ala 
305                 310                 315                 320 


Val Glu Val Cys Val Val Tyr Gly Asn Tyr Ser Gln Gln Leu Gln Val 
                325                 330                 335     


Tyr Ser Lys Thr Gly Phe Asn Cys Asp Gly Lys Leu Gly Asn Glu Ser 
            340                 345                 350         


Val Thr Phe Tyr Leu Gln Asn Leu Tyr Val Asn Gln Thr Asp Ile Tyr 
        355                 360                 365             


Phe Cys Lys Ile Glu Val Met Ala Pro Pro Pro Ala Leu Asp Asn Glu 
    370                 375                 380                 


Lys Ser Asn Gly Thr Ile Ile His Val Lys Gly Lys His Leu Cys Pro 
385                 390                 395                 400 


Ser Pro Leu Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val 
                405                 410                 415     


Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe 
            420                 425                 430         


Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg Gly Gly His Ser Asp 
        435                 440                 445             


Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr 
    450                 455                 460                 


Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Gly Gly 
465                 470                 475                 480 


Gly Gly Ser Gly Gly Gly Ala Ser Gly Gly Gly Gly Ser Phe Ser Arg 
                485                 490                 495     


Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn 
            500                 505                 510         


Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg 
        515                 520                 525             


Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro 
    530                 535                 540                 


Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala 
545                 550                 555                 560 


Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His 
                565                 570                 575     


Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Gly 
            580                 585                 590         


Ala Leu His Met Gln Ala Leu Pro Pro Arg 
        595                 600         


<210>  20
<211>  502
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Homo sapiens/Mus musculus chimera

<400>  20

Met Arg Arg Met Gln Leu Leu Leu Leu Ile Ala Leu Ser Leu Ala Leu 
1               5                   10                  15      


Val Thr Asn Ser Glu Phe Glu Val Gln Leu Val Glu Ser Gly Gly Gly 
            20                  25                  30          


Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
        35                  40                  45              


Phe Thr Phe Ser Asp Phe Trp Met Asn Trp Val Arg Gln Ala Pro Gly 
    50                  55                  60                  


Lys Gly Leu Glu Trp Val Gly Gln Ile Arg Asn Lys Pro Asn Asn Tyr 
65                  70                  75                  80  


Glu Thr Tyr Tyr Ser Asp Ser Leu Lys Gly Arg Phe Thr Ile Ser Arg 
                85                  90                  95      


Asp Asp Ser Lys Ser Ile Thr Tyr Leu Gln Met Asn Ser Leu Arg Ala 
            100                 105                 110         


Glu Asp Thr Ala Val Tyr Tyr Cys Thr Leu Gly Asn Ser Trp Phe Ala 
        115                 120                 125             


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val Met Thr 
145                 150                 155                 160 


Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly Glu Arg Ala Thr Ile 
                165                 170                 175     


Asn Cys Arg Ser Ser Gln Ser Leu Leu Asp Ser Arg Thr Lys Lys Asn 
            180                 185                 190         


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu 
        195                 200                 205             


Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val Pro Asp Arg Phe Ser 
    210                 215                 220                 


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln 
225                 230                 235                 240 


Ala Glu Asp Val Ala Val Tyr Tyr Cys Lys Gln Ser Tyr Asn Leu Pro 
                245                 250                 255     


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Gly Gly Gly Gly Ser 
            260                 265                 270         


Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala 
        275                 280                 285             


Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly 
    290                 295                 300                 


Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile 
305                 310                 315                 320 


Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val 
                325                 330                 335     


Ile Thr Leu Tyr Cys Gly Gly Gly Gly Ser Lys Arg Gly Arg Lys Lys 
            340                 345                 350         


Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr 
        355                 360                 365             


Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly 
    370                 375                 380                 


Gly Cys Glu Leu Gly Gly Gly Gly Ser Phe Ser Arg Ser Ala Asp Ala 
385                 390                 395                 400 


Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu 
                405                 410                 415     


Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp 
            420                 425                 430         


Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu 
        435                 440                 445             


Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile 
    450                 455                 460                 


Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr 
465                 470                 475                 480 


Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met 
                485                 490                 495     


Gln Ala Leu Pro Pro Arg 
            500         


<210>  21
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Homo sapiens/Mus musculus chimera

<400>  21

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr His Tyr 
            20                  25                  30          


Tyr Ile Tyr Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Val Asn Pro Ser Asn Gly Gly Thr His Phe Asn Glu Lys Phe 
    50                  55                  60                  


Lys Ser Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Glu Tyr Asp Tyr Gly Leu Gly Phe Ala Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  22
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Homo sapiens/Mus musculus chimera

<400>  22

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Arg Thr Pro Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Lys Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Lys Gln 
                85                  90                  95      


Ser Tyr Asn Leu Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210>  23
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Homo sapiens/Mus musculus chimera

<400>  23

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Phe 
            20                  25                  30          


Trp Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Gln Ile Arg Asn Lys Pro Asn Asn Tyr Glu Thr Tyr Tyr Ser Asp 
    50                  55                  60                  


Ser Leu Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Ile 
65                  70                  75                  80  


Thr Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Thr Leu Gly Asn Ser Trp Phe Ala Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  24
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Homo sapiens/Mus musculus chimera

<400>  24

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Arg Ser Ser Gln Ser Leu Leu Asp Ser 
            20                  25                  30          


Arg Thr Lys Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Lys Gln 
                85                  90                  95      


Ser Tyr Asn Leu Pro Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210>  25
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  25

Lys Pro Leu Pro Glu Val Thr Asp Glu Tyr 
1               5                   10  


<210>  26
<211>  48
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Homo sapiens

<400>  26

Cys Gly Glu Met Gly Trp Val Arg Cys Gly Gly Gly Gly Ser Gly Gly 
1               5                   10                  15      


Gly Gly Ser Lys Pro Leu Pro Glu Val Thr Asp Glu Tyr Gly Gly Gly 
            20                  25                  30          


Gly Ser Gly Gly Gly Gly Ser Cys Gly Glu Met Gly Trp Val Arg Cys 
        35                  40                  45              


<210>  27
<211>  18
<212>  PRT
<213>  Homo sapiens

<400>  27

Glu Lys Glu Ala Leu Lys Lys Ile Ile Glu Asp Gln Gln Glu Ser Leu 
1               5                   10                  15      


Asn Lys 
        


