                               SEQUENCE LISTING

<110> THE BOARD OF SUPERVISORS OF LOUISIANA STATE UNIVERSITY AND 
      AGRICULTURAL AND MECHANICAL COLLEGE
 
<120> ENGINEERED CELLS, AND METHODS OF USING THE SAME

<130> 2932719-009-WO1

<140> PCT/US2018/035822
<141> 2018-06-04

<150> 62/514,337
<151> 2017-06-02

<160> 16    

<170> PatentIn version 3.5

<210> 1
<211> 1771
<212> DNA
<213> Homo sapiens

<400> 1
tcgcgaggtt cgaaccatga aggacttctc agatgtcatc ctctgcatgg aggcaacaga       60

atcgagcaag accgagttct gcaatcctgc cttcgagcct gagtctgggc caccctgccc      120

tcccccagtt ttcccagagg atgccagcta cagcgtccca gctccctggc atggtcggcg      180

tcctcgaggg ctacggccag actgccgctt ctcctggctc tgtgtcctcc tgctctccag      240

cctgctcctc ctgctgcttg ggctgctggt ggccatcatc ctggcccagc tgcaggctgc      300

acccccatct ggggcgtccc atagcccact gcctgccgga ggccttacca cgaccaccac      360

cacccccacc atcaccacct ctcaggcagc tgggacccct aaagggcagc aggagtcagg      420

cgtgagcccc tccccacagt ccacctgtgg aggcctcctc tctggcccaa ggggcttctt      480

cagcagccct aactacccag acccttaccc ccccaacacc cactgcgtgt ggcatatcca      540

ggtggccaca gaccatgcaa tacagctcaa gatcgaagcc ctcagcatag agagtgtggc      600

ctcttgcctt tttgatcgct tggaactctc ccctgagcct gaaggccccc tcctcagggt      660

ttgtggaagg gtgcctcccc ccacgctcaa caccaatgcc agccacctcc tggtggtctt      720

cgtctctgac agcagtgtgg aaggatttgg tttccatgcc tggtaccagg ctatggcccc      780

tgggcgcggg agctgtgccc atgatgagtt ccgctgtgac cagctcatct gcctgctacc      840

tgactcagtg tgtgatggtt ttgccaactg tgctgacggc agtgatgaga ccaattgcag      900

tgccaagttc tcggggtgtg gggggaatct gactggcctc cagggcactt tctctactcc      960

cagctacctg cagcagtacc ctcaccaact gctctgcacc tggcatatct cggtgcctgc     1020

cggacacagc atagaactac agttccacaa cttcagcctg gaggctcagg acgagtgcaa     1080

gtttgactac gtggaggtgt atgagaccag cagctcaggg gccttcagcc tcctgggcag     1140

gttctgtgga gcagagccac ccccccacct cgtctcctcg caccatgagc tggctgtgct     1200

gtttaggaca gatcatggca tcagcagtgg aggcttctca gccacctacc tggccttcaa     1260

tgccacggag aacccctgtg ggcccagtga gctctcctgc caggcaggag ggtgtaaggg     1320

tgtgcagtgg atgtgtgaca tgtggagaga ctgcaccgat ggcagcgatg acaactgcag     1380

cggccccttg ttcccacccc cagagctggc ctgtgagcct gtccaggtgg agatgtgcct     1440

cggtctgagc tacaacacca cagccttccc taacatctgg gtgggcatga tcacccagga     1500

ggaggtggta gaggtcctca gcggttacaa gagcctgaca agcctgccct gctaccagca     1560

tttccggagg ctcctgtgtg ggctgcttgt gccccgttgc accccactag gcagtgttct     1620

gcccccttgc cgctctgtct gccaggaagc ggagcaccag tgccagtctg gcctggcact     1680

actgggcacc ccctggccct tcaactgcaa caggctgcca gaggcagctg acctggaagc     1740

ttgtgcccag ccctagctcg agtgcggccg c                                    1771


<210> 2
<211> 1153
<212> DNA
<213> Homo sapiens

<400> 2
tcgcgaggtt cgaaccatgt cttcccacaa aggatctgtg gtggcacagg ggaatggggc       60

tcctgccagt aacagggaag ctgacacggt ggaactggct gaactgggac ccctgctaga      120

agagaagggc aaacgggtaa tcgccaaccc acccaaagct gaagaagagc aaacatgccc      180

agtgccccag gaagaagagg aggaggtgcg ggtactgaca cttcccctgc aagcccacca      240

cgccatggag aagatggaag agtttgtgta caaggtctgg gagggacgtt ggagggtcat      300

cccatatgat gtgctccctg actggctaaa ggacaacgac tatctgctac atggtcatag      360

acctcccatg ccctcctttc gggcttgctt caagagcatc ttccgcattc atacagaaac      420

tggcaacatc tggacccatc tgcttggttt cgtgctgttt ctctttttgg gaatcttgac      480

catgctcaga ccaaatatgt acttcatggc ccctctacag gagaaggtgg tttttgggat      540

gttctttttg ggtgcagtgc tctgcctcag cttctcctgg ctctttcaca ccgtctattg      600

tcattcagag aaagtctctc ggactttttc caaactggac tattcaggga ttgctcttct      660

aattatgggg agctttgtcc cctggctcta ttattccttc tactgctccc cacagccacg      720

gctcatctac ctctccatcg tctgtgtcct gggcatttct gccatcattg tggcgcagtg      780

ggaccggttt gccactccta agcaccggca gacaagagca ggcgtgttcc tgggacttgg      840

cttgagtggc gtcgtgccca ccatgcactt tactatcgct gagggctttg tcaaggccac      900

cacagtgggc cagatgggct ggttcttcct catggctgtg atgtacatca ctggagctgg      960

cctttatgct gctcgaattc ctgagcgctt ctttcctgga aaatttgaca tatggttcca     1020

gtctcatcag attttccatg tcctggtggt ggcagcagcc tttgtccact tctatggagt     1080

ctccaacctt caggaattcc gttacggcct agaaggcggc tgtactgatg acacccttct     1140

ctagctcgag tgc                                                        1153


<210> 3
<211> 375
<212> PRT
<213> Homo sapiens

<400> 3
Met Ser Ser His Lys Gly Ser Val Val Ala Gln Gly Asn Gly Ala Pro 
1               5                   10                  15      


Ala Ser Asn Arg Glu Ala Asp Thr Val Glu Leu Ala Glu Leu Gly Pro 
            20                  25                  30          


Leu Leu Glu Glu Lys Gly Lys Arg Val Ile Ala Asn Pro Pro Lys Ala 
        35                  40                  45              


Glu Glu Glu Gln Thr Cys Pro Val Pro Gln Glu Glu Glu Glu Glu Val 
    50                  55                  60                  


Arg Val Leu Thr Leu Pro Leu Gln Ala His His Ala Met Glu Lys Met 
65                  70                  75                  80  


Glu Glu Phe Val Tyr Lys Val Trp Glu Gly Arg Trp Arg Val Ile Pro 
                85                  90                  95      


Tyr Asp Val Leu Pro Asp Trp Leu Lys Asp Asn Asp Tyr Leu Leu His 
            100                 105                 110         


Gly His Arg Pro Pro Met Pro Ser Phe Arg Ala Cys Phe Lys Ser Ile 
        115                 120                 125             


Phe Arg Ile His Thr Glu Thr Gly Asn Ile Trp Thr His Leu Leu Gly 
    130                 135                 140                 


Phe Val Leu Phe Leu Phe Leu Gly Ile Leu Thr Met Leu Arg Pro Asn 
145                 150                 155                 160 


Met Tyr Phe Met Ala Pro Leu Gln Glu Lys Val Val Phe Gly Met Phe 
                165                 170                 175     


Phe Leu Gly Ala Val Leu Cys Leu Ser Phe Ser Trp Leu Phe His Thr 
            180                 185                 190         


Val Tyr Cys His Ser Glu Lys Val Ser Arg Thr Phe Ser Lys Leu Asp 
        195                 200                 205             


Tyr Ser Gly Ile Ala Leu Leu Ile Met Gly Ser Phe Val Pro Trp Leu 
    210                 215                 220                 


Tyr Tyr Ser Phe Tyr Cys Ser Pro Gln Pro Arg Leu Ile Tyr Leu Ser 
225                 230                 235                 240 


Ile Val Cys Val Leu Gly Ile Ser Ala Ile Ile Val Ala Gln Trp Asp 
                245                 250                 255     


Arg Phe Ala Thr Pro Lys His Arg Gln Thr Arg Ala Gly Val Phe Leu 
            260                 265                 270         


Gly Leu Gly Leu Ser Gly Val Val Pro Thr Met His Phe Thr Ile Ala 
        275                 280                 285             


Glu Gly Phe Val Lys Ala Thr Thr Val Gly Gln Met Gly Trp Phe Phe 
    290                 295                 300                 


Leu Met Ala Val Met Tyr Ile Thr Gly Ala Gly Leu Tyr Ala Ala Arg 
305                 310                 315                 320 


Ile Pro Glu Arg Phe Phe Pro Gly Lys Phe Asp Ile Trp Phe Gln Ser 
                325                 330                 335     


His Gln Ile Phe His Val Leu Val Val Ala Ala Ala Phe Val His Phe 
            340                 345                 350         


Tyr Gly Val Ser Asn Leu Gln Glu Phe Arg Tyr Gly Leu Glu Gly Gly 
        355                 360                 365             


Cys Thr Asp Asp Thr Leu Leu 
    370                 375 


<210> 4
<211> 375
<212> PRT
<213> Mus musculus

<400> 4
Met Ser Ser His Lys Gly Ser Ala Gly Ala Gln Gly Asn Gly Ala Pro 
1               5                   10                  15      


Ser Gly Asn Arg Glu Ala Asp Thr Val Glu Leu Ala Glu Leu Gly Pro 
            20                  25                  30          


Leu Leu Glu Glu Lys Gly Lys Arg Ala Ala Ser Ser Pro Ala Lys Ala 
        35                  40                  45              


Glu Glu Asp Gln Ala Cys Pro Val Pro Gln Glu Glu Glu Glu Glu Val 
    50                  55                  60                  


Arg Val Leu Thr Leu Pro Leu Gln Ala His His Ala Met Glu Lys Met 
65                  70                  75                  80  


Glu Glu Phe Val Tyr Lys Val Trp Glu Gly Arg Trp Arg Val Ile Pro 
                85                  90                  95      


Tyr Asp Val Leu Pro Asp Trp Leu Lys Asp Asn Asp Tyr Leu Leu His 
            100                 105                 110         


Gly His Arg Pro Pro Met Pro Ser Phe Arg Ala Cys Phe Lys Ser Ile 
        115                 120                 125             


Phe Arg Ile His Thr Glu Thr Gly Asn Ile Trp Thr His Leu Leu Gly 
    130                 135                 140                 


Phe Val Leu Phe Leu Phe Leu Gly Ile Leu Thr Met Leu Arg Pro Asn 
145                 150                 155                 160 


Met Tyr Phe Met Ala Pro Leu Gln Glu Lys Val Val Phe Gly Met Phe 
                165                 170                 175     


Phe Leu Gly Ala Val Leu Cys Leu Ser Phe Ser Trp Leu Phe His Thr 
            180                 185                 190         


Val Tyr Cys His Ser Glu Lys Val Ser Arg Thr Phe Ser Lys Leu Asp 
        195                 200                 205             


Tyr Ser Gly Ile Ala Leu Leu Ile Met Gly Ser Phe Val Pro Trp Leu 
    210                 215                 220                 


Tyr Tyr Ser Phe Tyr Cys Ser Pro Gln Pro Arg Leu Ile Tyr Leu Ser 
225                 230                 235                 240 


Ile Val Cys Val Leu Gly Ile Ser Ala Ile Ile Val Ala Gln Trp Asp 
                245                 250                 255     


Arg Phe Ala Thr Pro Lys His Arg Gln Thr Arg Ala Gly Val Phe Leu 
            260                 265                 270         


Gly Leu Gly Leu Ser Gly Val Val Pro Thr Met His Phe Thr Ile Ala 
        275                 280                 285             


Glu Gly Phe Val Lys Ala Thr Thr Val Gly Gln Met Gly Trp Phe Phe 
    290                 295                 300                 


Leu Met Ala Val Met Tyr Ile Thr Gly Ala Gly Leu Tyr Ala Ala Arg 
305                 310                 315                 320 


Ile Pro Glu Arg Phe Phe Pro Gly Lys Phe Asp Ile Trp Phe Gln Ser 
                325                 330                 335     


His Gln Ile Phe His Val Leu Val Val Ala Ala Ala Phe Val His Phe 
            340                 345                 350         


Tyr Gly Val Ser Asn Leu Gln Glu Phe Arg Tyr Gly Leu Glu Gly Gly 
        355                 360                 365             


Cys Thr Asp Asp Ser Leu Leu 
    370                 375 


<210> 5
<211> 579
<212> PRT
<213> Homo sapiens

<400> 5
Met Lys Asp Phe Ser Asp Val Ile Leu Cys Met Glu Ala Thr Glu Ser 
1               5                   10                  15      


Ser Lys Thr Glu Phe Cys Asn Pro Ala Phe Glu Pro Glu Ser Gly Pro 
            20                  25                  30          


Pro Cys Pro Pro Pro Val Phe Pro Glu Asp Ala Ser Tyr Ser Val Pro 
        35                  40                  45              


Ala Pro Trp His Gly Arg Arg Pro Arg Gly Leu Arg Pro Asp Cys Arg 
    50                  55                  60                  


Phe Ser Trp Leu Cys Val Leu Leu Leu Ser Ser Leu Leu Leu Leu Leu 
65                  70                  75                  80  


Leu Gly Leu Leu Val Ala Ile Ile Leu Ala Gln Leu Gln Ala Ala Pro 
                85                  90                  95      


Pro Ser Gly Ala Ser His Ser Pro Leu Pro Ala Gly Gly Leu Thr Thr 
            100                 105                 110         


Thr Thr Thr Thr Pro Thr Ile Thr Thr Ser Gln Ala Ala Gly Thr Pro 
        115                 120                 125             


Lys Gly Gln Gln Glu Ser Gly Val Ser Pro Ser Pro Gln Ser Thr Cys 
    130                 135                 140                 


Gly Gly Leu Leu Ser Gly Pro Arg Gly Phe Phe Ser Ser Pro Asn Tyr 
145                 150                 155                 160 


Pro Asp Pro Tyr Pro Pro Asn Thr His Cys Val Trp His Ile Gln Val 
                165                 170                 175     


Ala Thr Asp His Ala Ile Gln Leu Lys Ile Glu Ala Leu Ser Ile Glu 
            180                 185                 190         


Ser Val Ala Ser Cys Leu Phe Asp Arg Leu Glu Leu Ser Pro Glu Pro 
        195                 200                 205             


Glu Gly Pro Leu Leu Arg Val Cys Gly Arg Val Pro Pro Pro Thr Leu 
    210                 215                 220                 


Asn Thr Asn Ala Ser His Leu Leu Val Val Phe Val Ser Asp Ser Ser 
225                 230                 235                 240 


Val Glu Gly Phe Gly Phe His Ala Trp Tyr Gln Ala Met Ala Pro Gly 
                245                 250                 255     


Arg Gly Ser Cys Ala His Asp Glu Phe Arg Cys Asp Gln Leu Ile Cys 
            260                 265                 270         


Leu Leu Pro Asp Ser Val Cys Asp Gly Phe Ala Asn Cys Ala Asp Gly 
        275                 280                 285             


Ser Asp Glu Thr Asn Cys Ser Ala Lys Phe Ser Gly Cys Gly Gly Asn 
    290                 295                 300                 


Leu Thr Gly Leu Gln Gly Thr Phe Ser Thr Pro Ser Tyr Leu Gln Gln 
305                 310                 315                 320 


Tyr Pro His Gln Leu Leu Cys Thr Trp His Ile Ser Val Pro Ala Gly 
                325                 330                 335     


His Ser Ile Glu Leu Gln Phe His Asn Phe Ser Leu Glu Ala Gln Asp 
            340                 345                 350         


Glu Cys Lys Phe Asp Tyr Val Glu Val Tyr Glu Thr Ser Ser Ser Gly 
        355                 360                 365             


Ala Phe Ser Leu Leu Gly Arg Phe Cys Gly Ala Glu Pro Pro Pro His 
    370                 375                 380                 


Leu Val Ser Ser His His Glu Leu Ala Val Leu Phe Arg Thr Asp His 
385                 390                 395                 400 


Gly Ile Ser Ser Gly Gly Phe Ser Ala Thr Tyr Leu Ala Phe Asn Ala 
                405                 410                 415     


Thr Glu Asn Pro Cys Gly Pro Ser Glu Leu Ser Cys Gln Ala Gly Gly 
            420                 425                 430         


Cys Lys Gly Val Gln Trp Met Cys Asp Met Trp Arg Asp Cys Thr Asp 
        435                 440                 445             


Gly Ser Asp Asp Asn Cys Ser Gly Pro Leu Phe Pro Pro Pro Glu Leu 
    450                 455                 460                 


Ala Cys Glu Pro Val Gln Val Glu Met Cys Leu Gly Leu Ser Tyr Asn 
465                 470                 475                 480 


Thr Thr Ala Phe Pro Asn Ile Trp Val Gly Met Ile Thr Gln Glu Glu 
                485                 490                 495     


Val Val Glu Val Leu Ser Gly Tyr Lys Ser Leu Thr Ser Leu Pro Cys 
            500                 505                 510         


Tyr Gln His Phe Arg Arg Leu Leu Cys Gly Leu Leu Val Pro Arg Cys 
        515                 520                 525             


Thr Pro Leu Gly Ser Val Leu Pro Pro Cys Arg Ser Val Cys Gln Glu 
    530                 535                 540                 


Ala Glu His Gln Cys Gln Ser Gly Leu Ala Leu Leu Gly Thr Pro Trp 
545                 550                 555                 560 


Pro Phe Asn Cys Asn Arg Leu Pro Glu Ala Ala Asp Leu Glu Ala Cys 
                565                 570                 575     


Ala Gln Pro 
            


<210> 6
<211> 578
<212> PRT
<213> Mus musculus

<400> 6
Met Lys Asp Tyr Asp Asp Val Ile Leu Arg Pro Glu Ala Ser Glu Leu 
1               5                   10                  15      


Ser Lys Thr Glu Phe Cys Asn Pro Ala Phe Asp Pro Glu Ala Gly Pro 
            20                  25                  30          


Ser Cys Pro Pro Pro Ala Leu Gln Arg Asp Val Gly Ser Arg Leu Gln 
        35                  40                  45              


Ala Pro Trp His Ala Gln Arg Leu Arg Gly Leu Gln Pro Asp Cys His 
    50                  55                  60                  


Phe Ser Trp Phe Cys Ile Leu Leu Leu Ser Gly Leu Leu Leu Leu Leu 
65                  70                  75                  80  


Leu Gly Leu Leu Val Ala Val Ile Leu Ala Gln Leu Gln Ala Thr Ser 
                85                  90                  95      


Leu Pro Arg Thr Thr Lys Asn Pro Leu Leu Thr Arg Gly Leu Thr Pro 
            100                 105                 110         


Met Gly Val Ile Pro Ser Thr Thr Pro Asn Thr Thr Thr Thr Thr Thr 
        115                 120                 125             


Thr Thr Thr Pro Ala Arg Thr Gly Gln Gln Glu Ala Ala Met Ser Pro 
    130                 135                 140                 


Thr His Gln Thr Thr Cys Gly Gly Leu Leu Pro Gly Pro Ser Gly Phe 
145                 150                 155                 160 


Phe Ser Ser Pro Asn Tyr Pro Asp Leu Tyr Pro Pro Leu Ser His Cys 
                165                 170                 175     


Val Trp His Ile Gln Val Ala Ala Gly Gln Thr Ile Gln Leu Lys Ile 
            180                 185                 190         


Gln Ala Leu Ser Ile Glu Ser Met Leu Thr Cys Leu Phe Asp Arg Leu 
        195                 200                 205             


Glu Ile Ile Ser Glu Pro Thr Gly Pro Leu Leu Arg Val Cys Gly Lys 
    210                 215                 220                 


Thr Pro Pro Ala Thr Leu Asn Thr Asn Thr Ser His Leu Arg Val Ser 
225                 230                 235                 240 


Phe Val Ser Asp Asn Asp Val Glu Gly Ser Gly Phe Gln Ala Trp Tyr 
                245                 250                 255     


Gln Ala Val Ala Pro Gly His Trp Ser Cys Ala His Asn Glu Phe His 
            260                 265                 270         


Cys Asp Leu Leu Leu Cys Leu Lys Arg Asp Ser Val Cys Asp Gly Ile 
        275                 280                 285             


Thr Glu Cys Ala Asp Gly Ser Asp Glu Ala Asn Cys Ser Ala Lys Thr 
    290                 295                 300                 


Leu Gly Cys Gly Gly Asn Leu Thr Gly Leu Tyr Gly Val Phe Ser Thr 
305                 310                 315                 320 


Pro Asn Tyr Pro Gln His Tyr Pro His Gln Gln Leu Cys Thr Trp Tyr 
                325                 330                 335     


Ile Glu Val Pro Val Gly Tyr Gly Ile Arg Leu Glu Phe His Asn Phe 
            340                 345                 350         


Ser Leu Glu Ala Gln Ala Glu Cys Lys Phe Asp Tyr Val Glu Val Tyr 
        355                 360                 365             


Glu Ala Ser Asn Leu Gly Thr Phe Ser Phe Leu Gly Arg Phe Cys Gly 
    370                 375                 380                 


Ala Glu Pro Pro Leu Asn Val Val Ser Ser Met His Gln Leu Ala Val 
385                 390                 395                 400 


Ile Phe Lys Thr Asp Leu Gly Ile Ser Ser Gly Gly Phe Leu Ala Thr 
                405                 410                 415     


Tyr Gln Ala Ile Asn Thr Thr Glu Lys Phe Cys Gln Ser Gly Gly Tyr 
            420                 425                 430         


Arg Asp Leu Gln Trp Met Cys Asp Leu Trp Lys Asp Cys Ala Asn Asp 
        435                 440                 445             


Ser Asn Asp Asn Cys Ser Ser His Leu Ser Pro Gln Pro Asp Leu Thr 
    450                 455                 460                 


Cys Glu Pro Val Gln Val Glu Met Cys Leu Gly Leu Ser Tyr Asn Thr 
465                 470                 475                 480 


Thr Ala Phe Pro Asn Ile Trp Val Gly Leu Ala Thr Gln Thr Glu Val 
                485                 490                 495     


Thr Asp Ile Leu Arg Gly Tyr Lys Ser Leu Thr Ser Leu Pro Cys Tyr 
            500                 505                 510         


Gln Thr Phe Gln Arg Phe Leu Cys Gly Leu Leu Val Pro Arg Cys Thr 
        515                 520                 525             


Ser Leu Gly Thr Ile Leu Pro Pro Cys Arg Ser Val Cys Gln Ala Ala 
    530                 535                 540                 


Glu Gln Gln Cys Gln Ser Ser Leu Ala Leu Leu Gly Thr Pro Trp Pro 
545                 550                 555                 560 


Phe Asn Cys Asn Arg Leu Pro Val Ala Ala Ser Leu Glu Ala Cys Ser 
                565                 570                 575     


Gln Pro 
        


<210> 7
<211> 584
<212> PRT
<213> Mus musculus

<400> 7
Met Lys Asp Tyr Asp Asp Val Ile Leu Arg Pro Glu Ala Ser Glu Leu 
1               5                   10                  15      


Ser Lys Thr Glu Phe Cys Asn Pro Ala Phe Asp Pro Glu Ala Gly Pro 
            20                  25                  30          


Ser Cys Pro Pro Pro Ala Leu Gln Arg Asp Val Gly Ser Arg Leu Gln 
        35                  40                  45              


Ala Pro Trp His Ala Gln Arg Leu Arg Gly Leu Gln Pro Asp Cys His 
    50                  55                  60                  


Phe Ser Trp Phe Cys Ile Leu Leu Leu Ser Gly Leu Leu Leu Leu Leu 
65                  70                  75                  80  


Leu Gly Leu Leu Val Ala Val Ile Leu Ala Gln Leu Gln Ala Thr Ser 
                85                  90                  95      


Leu Pro Arg Thr Thr Lys Asn Pro Leu Leu Thr Arg Gly Leu Thr Pro 
            100                 105                 110         


Met Gly Val Ile Pro Ser Thr Thr Pro Asn Thr Thr Thr Thr Thr Thr 
        115                 120                 125             


Thr Thr Thr Pro Ala Arg Thr Gly Gln Gln Glu Ala Ala Met Ser Pro 
    130                 135                 140                 


Thr His Gln Thr Thr Cys Gly Gly Leu Leu Pro Gly Pro Ser Gly Phe 
145                 150                 155                 160 


Phe Ser Ser Pro Asn Tyr Pro Asp Leu Tyr Pro Pro Leu Ser His Cys 
                165                 170                 175     


Val Trp His Ile Gln Val Ala Ala Gly Gln Thr Ile Gln Leu Lys Ile 
            180                 185                 190         


Gln Ala Leu Ser Ile Glu Ser Met Leu Thr Cys Leu Phe Asp Arg Leu 
        195                 200                 205             


Glu Ile Ile Ser Glu Pro Thr Gly Pro Leu Leu Arg Val Cys Gly Lys 
    210                 215                 220                 


Thr Pro Pro Ala Thr Leu Asn Thr Asn Thr Ser His Leu Arg Val Ser 
225                 230                 235                 240 


Phe Val Ser Asp Asn Asp Val Glu Gly Ser Gly Phe Gln Ala Trp Tyr 
                245                 250                 255     


Gln Ala Val Ala Pro Gly His Trp Ser Cys Ala His Asn Glu Phe His 
            260                 265                 270         


Cys Asp Leu Leu Leu Cys Leu Lys Arg Asp Ser Val Cys Asp Gly Ile 
        275                 280                 285             


Thr Glu Cys Ala Asp Gly Ser Asp Glu Ala Asn Cys Ser Ala Lys Thr 
    290                 295                 300                 


Leu Gly Cys Gly Gly Asn Leu Thr Gly Leu Tyr Gly Val Phe Ser Thr 
305                 310                 315                 320 


Pro Asn Tyr Pro Gln His Tyr Pro His Gln Gln Leu Cys Thr Trp Tyr 
                325                 330                 335     


Ile Glu Val Pro Val Gly Tyr Gly Ile Arg Leu Glu Phe His Asn Phe 
            340                 345                 350         


Ser Leu Glu Ala Gln Ala Glu Cys Lys Phe Asp Tyr Val Glu Val Tyr 
        355                 360                 365             


Glu Ala Ser Asn Leu Gly Thr Phe Ser Phe Leu Gly Arg Phe Cys Gly 
    370                 375                 380                 


Ala Glu Pro Pro Leu Asn Val Val Ser Ser Met His Gln Leu Ala Val 
385                 390                 395                 400 


Ile Phe Lys Thr Asp Leu Gly Ile Ser Ser Gly Gly Phe Leu Ala Thr 
                405                 410                 415     


Tyr Gln Ala Ile Asn Thr Thr Glu Ser Gly Cys Pro Trp Ala Glu Phe 
            420                 425                 430         


Cys Gln Ser Gly Gly Tyr Arg Asp Leu Gln Trp Met Cys Asp Leu Trp 
        435                 440                 445             


Lys Asp Cys Ala Asn Asp Ser Asn Asp Asn Cys Ser Ser His Leu Ser 
    450                 455                 460                 


Pro Gln Pro Asp Leu Thr Cys Glu Pro Val Gln Val Glu Met Cys Leu 
465                 470                 475                 480 


Gly Leu Ser Tyr Asn Thr Thr Ala Phe Pro Asn Ile Trp Val Gly Leu 
                485                 490                 495     


Ala Thr Gln Thr Glu Val Thr Asp Ile Leu Arg Gly Tyr Lys Ser Leu 
            500                 505                 510         


Thr Ser Leu Pro Cys Tyr Gln Thr Phe Gln Arg Phe Leu Cys Gly Leu 
        515                 520                 525             


Leu Val Pro Arg Cys Thr Ser Leu Gly Thr Ile Leu Pro Pro Cys Arg 
    530                 535                 540                 


Ser Val Cys Gln Ala Ala Glu Gln Gln Cys Gln Ser Ser Leu Ala Leu 
545                 550                 555                 560 


Leu Gly Thr Pro Trp Pro Phe Asn Cys Asn Arg Leu Pro Val Ala Ala 
                565                 570                 575     


Ser Leu Glu Ala Cys Ser Gln Pro 
            580                 


<210> 8
<211> 1734
<212> DNA
<213> Homo sapiens

<400> 8
aaggacttct cagatgtcat cctctgcatg gaggcaacag aatcgagcaa gaccgagttc       60

tgcaatcctg ccttcgagcc tgagtctggg ccaccctgcc ctcccccagt tttcccagag      120

gatgccagct acagcgtccc agctccctgg catggtcggc gtcctcgagg gctacggcca      180

gactgccgct tctcctggct ctgtgtcctc ctgctctcca gcctgctcct cctgctgctt      240

gggctgctgg tggccatcat cctggcccag ctgcaggctg cacccccatc tggggcgtcc      300

catagcccac tgcctgccgg aggccttacc acgaccacca ccacccccac catcaccacc      360

tctcaggcag ctgggacccc taaagggcag caggagtcag gcgtgagccc ctccccacag      420

tccacctgtg gaggcctcct ctctggccca aggggcttct tcagcagccc taactaccca      480

gacccttacc cccccaacac ccactgcgtg tggcatatcc aggtggccac agaccatgca      540

atacagctca agatcgaagc cctcagcata gagagtgtgg cctcttgcct ttttgatcgc      600

ttggaactct cccctgagcc tgaaggcccc ctcctcaggg tttgtggaag ggtgcctccc      660

cccacgctca acaccaatgc cagccacctc ctggtggtct tcgtctctga cagcagtgtg      720

gaaggatttg gtttccatgc ctggtaccag gctatggccc ctgggcgcgg gagctgtgcc      780

catgatgagt tccgctgtga ccagctcatc tgcctgctac ctgactcagt gtgtgatggt      840

tttgccaact gtgctgacgg cagtgatgag accaattgca gtgccaagtt ctcggggtgt      900

ggggggaatc tgactggcct ccagggcact ttctctactc ccagctacct gcagcagtac      960

cctcaccaac tgctctgcac ctggcatatc tcggtgcctg ccggacacag catagaacta     1020

cagttccaca acttcagcct ggaggctcag gacgagtgca agtttgacta cgtggaggtg     1080

tatgagacca gcagctcagg ggccttcagc ctcctgggca ggttctgtgg agcagagcca     1140

cccccccacc tcgtctcctc gcaccatgag ctggctgtgc tgtttaggac agatcatggc     1200

atcagcagtg gaggcttctc agccacctac ctggccttca atgccacgga gaacccctgt     1260

gggcccagtg agctctcctg ccaggcagga gggtgtaagg gtgtgcagtg gatgtgtgac     1320

atgtggagag actgcaccga tggcagcgat gacaactgca gcggcccctt gttcccaccc     1380

ccagagctgg cctgtgagcc tgtccaggtg gagatgtgcc tcggtctgag ctacaacacc     1440

acagccttcc ctaacatctg ggtgggcatg atcacccagg aggaggtggt agaggtcctc     1500

agcggttaca agagcctgac aagcctgccc tgctaccagc atttccggag gctcctgtgt     1560

gggctgcttg tgccccgttg caccccacta ggcagtgttc tgcccccttg ccgctctgtc     1620

tgccaggaag cggagcacca gtgccagtct ggcctggcac tactgggcac cccctggccc     1680

ttcaactgca acaggctgcc agaggcagct gacctggaag cttgtgccca gccc           1734


<210> 9
<211> 1122
<212> DNA
<213> Homo sapiens

<400> 9
tcttcccaca aaggatctgt ggtggcacag gggaatgggg ctcctgccag taacagggaa       60

gctgacacgg tggaactggc tgaactggga cccctgctag aagagaaggg caaacgggta      120

atcgccaacc cacccaaagc tgaagaagag caaacatgcc cagtgcccca ggaagaagag      180

gaggaggtgc gggtactgac acttcccctg caagcccacc acgccatgga gaagatggaa      240

gagtttgtgt acaaggtctg ggagggacgt tggagggtca tcccatatga tgtgctccct      300

gactggctaa aggacaacga ctatctgcta catggtcata gacctcccat gccctccttt      360

cgggcttgct tcaagagcat cttccgcatt catacagaaa ctggcaacat ctggacccat      420

ctgcttggtt tcgtgctgtt tctctttttg ggaatcttga ccatgctcag accaaatatg      480

tacttcatgg cccctctaca ggagaaggtg gtttttggga tgttcttttt gggtgcagtg      540

ctctgcctca gcttctcctg gctctttcac accgtctatt gtcattcaga gaaagtctct      600

cggacttttt ccaaactgga ctattcaggg attgctcttc taattatggg gagctttgtc      660

ccctggctct attattcctt ctactgctcc ccacagccac ggctcatcta cctctccatc      720

gtctgtgtcc tgggcatttc tgccatcatt gtggcgcagt gggaccggtt tgccactcct      780

aagcaccggc agacaagagc aggcgtgttc ctgggacttg gcttgagtgg cgtcgtgccc      840

accatgcact ttactatcgc tgagggcttt gtcaaggcca ccacagtggg ccagatgggc      900

tggttcttcc tcatggctgt gatgtacatc actggagctg gcctttatgc tgctcgaatt      960

cctgagcgct tctttcctgg aaaatttgac atatggttcc agtctcatca gattttccat     1020

gtcctggtgg tggcagcagc ctttgtccac ttctatggag tctccaacct tcaggaattc     1080

cgttacggcc tagaaggcgg ctgtactgat gacacccttc tc                        1122


<210> 10
<211> 10467
<212> DNA
<213> Homo sapiens

<400> 10
aacccagctt tcttgtacaa agtggttgat cgcgtgcatg cgacgtcata gctctctccc       60

aattctcgac ctcgagacaa atggcagtat tcatccacaa ttttaaaaga aaagggggga      120

ttggggggta cagtgcaggg gaaagaatag tagacataat agcaacagac atacaaacta      180

aagaattaca aaaacaaatt acaaaaattc aaaattttcg ggtttattac agggacagca      240

gagatccact ttggccgcgg ctcgaggggg ttggggttgc gccttttcca aggcagccct      300

gggtttgcgc agggacgcgg ctgctctggg cgtggttccg ggaaacgcag cggcgccgac      360

cctgggtctc gcacattctt cacgtccgtt cgcagcgtca cccggatctt cgccgctacc      420

cttgtgggcc ccccggcgac gcttcctgct ccgcccctaa gtcgggaagg ttccttgcgg      480

ttcgcggcgt gccggacgtg acaaacggaa gccgcacgtc tcactagtac cctcgcagac      540

ggacagcgcc agggagcaat ggcagcgcgc cgaccgcgat gggctgtggc caatagcggc      600

tgctcagcag ggcgcgccga gagcagcggc cgggaagggg cggtgcggga ggcggggtgt      660

ggggcggtag tgtgggccct gttcctgccc gcgcggtgtt ccgcattctg caagcctccg      720

gagcgcacgt cggcagtcgg ctccctcgtt gaccgaatca ccgacctctc tccccagggg      780

gatccaccgg agcttaccat gaccgagtac aagcccacgg tgcgcctcgc cacccgcgac      840

gacgtcccca gggcggtacg caccctcgcc gccgcgttcg ccgactaccc cgccacgcgc      900

cacaccgtcg atccggaccg ccacatcgag cgggtcaccg agctgcaaga actcttcctc      960

acgcgcgtcg ggctcgacat cggcaaggtg tgggtcgcgg acgacggcgc cgcggtggcg     1020

gtctggacca cgccggagag cgtcgaagcg ggggcggtgt tcgccgagat cggcccgcgc     1080

atggccgagt tgagcggttc ccggctggcc gcgcagcaac agatggaagg cctcctggcg     1140

ccgcaccggc ccaaggagcc cgcgtggttc ctggccaccg tcggcgtctc gcccgaccac     1200

cagggcaagg gtctgggcag cgccgtcgtg ctccccggag tggaggcggc cgagcgcgcc     1260

ggggtgcccg ccttcctgga gacctccgcg ccccgcaacc tccccttcta cgagcggctc     1320

ggcttcaccg tcaccgccga cgtcgaggtg cccgaaggac cgcgcacctg gtgcatgacc     1380

cgcaagcccg gtgcctgacg cccgccccac gacccgcagc gcccgaccga aaggagcgca     1440

cgaccccatg catcggtacc tttaagacca atgacttaca aggcagctgt agatcttagc     1500

cactttttaa aagaaaaggg gggactggaa gggctaattc actcccaacg aagacaagat     1560

ctgctttttg cttgtactgg gtctctctgg ttagaccaga tctgagcctg ggagctctct     1620

ggctaactag ggaacccact gcttaagcct caataaagct tgccttgagt gcttcaagta     1680

gtgtgtgccc gtctgttgtg tgactctggt aactagagat ccctcagacc cttttagtca     1740

gtgtggaaaa tctctagcag tagtagttca tgtcatctta ttattcagta tttataactt     1800

gcaaagaaat gaatatcaga gagtgagagg aacttgttta ttgcagctta taatggttac     1860

aaataaagca atagcatcac aaatttcaca aataaagcat ttttttcact gcattctagt     1920

tgtggtttgt ccaaactcat caatgtatct tatcatgtct ggctctagct atcccgcccc     1980

taactccgcc catcccgccc ctaactccgc ccagttccgc ccattctccg ccccatggct     2040

gactaatttt ttttatttat gcagaggccg aggccgcctc ggcctctgag ctattccaga     2100

agtagtgagg aggctttttt ggaggcctag ggacgtaccc aattcgccct atagtgagtc     2160

gtattacgcg cgctcactgg ccgtcgtttt acaacgtcgt gactgggaaa accctggcgt     2220

tacccaactt aatcgccttg cagcacatcc ccctttcgcc agctggcgta atagcgaaga     2280

ggcccgcacc gatcgccctt cccaacagtt gcgcagcctg aatggcgaat gggacgcgcc     2340

ctgtagcggc gcattaagcg cggcgggtgt ggtggttacg cgcagcgtga ccgctacact     2400

tgccagcgcc ctagcgcccg ctcctttcgc tttcttccct tcctttctcg ccacgttcgc     2460

cggctttccc cgtcaagctc taaatcgggg gctcccttta gggttccgat ttagtgcttt     2520

acggcacctc gaccccaaaa aacttgatta gggtgatggt tcacgtagtg ggccatcgcc     2580

ctgatagacg gtttttcgcc ctttgacgtt ggagtccacg ttctttaata gtggactctt     2640

gttccaaact ggaacaacac tcaaccctat ctcggtctat tcttttgatt tataagggat     2700

tttgccgatt tcggcctatt ggttaaaaaa tgagctgatt taacaaaaat ttaacgcgaa     2760

ttttaacaaa atattaacgc ttacaattta ggtggcactt ttcggggaaa tgtgcgcgga     2820

acccctattt gtttattttt ctaaatacat tcaaatatgt atccgctcat gagacaataa     2880

ccctgataaa tgcttcaata atattgaaaa aggaagagta tgagtattca acatttccgt     2940

gtcgccctta ttcccttttt tgcggcattt tgccttcctg tttttgctca cccagaaacg     3000

ctggtgaaag taaaagatgc tgaagatcag ttgggtgcac gagtgggtta catcgaactg     3060

gatctcaaca gcggtaagat ccttgagagt tttcgccccg aagaacgttt tccaatgatg     3120

agcactttta aagttctgct atgtggcgcg gtattatccc gtattgacgc cgggcaagag     3180

caactcggtc gccgcataca ctattctcag aatgacttgg ttgagtactc accagtcaca     3240

gaaaagcatc ttacggatgg catgacagta agagaattat gcagtgctgc cataaccatg     3300

agtgataaca ctgcggccaa cttacttctg acaacgatcg gaggaccgaa ggagctaacc     3360

gcttttttgc acaacatggg ggatcatgta actcgccttg atcgttggga accggagctg     3420

aatgaagcca taccaaacga cgagcgtgac accacgatgc ctgtagcaat ggcaacaacg     3480

ttgcgcaaac tattaactgg cgaactactt actctagctt cccggcaaca attaatagac     3540

tggatggagg cggataaagt tgcaggacca cttctgcgct cggcccttcc ggctggctgg     3600

tttattgctg ataaatctgg agccggtgag cgtgggtctc gcggtatcat tgcagcactg     3660

gggccagatg gtaagccctc ccgtatcgta gttatctaca cgacggggag tcaggcaact     3720

atggatgaac gaaatagaca gatcgctgag ataggtgcct cactgattaa gcattggtaa     3780

ctgtcagacc aagtttactc atatatactt tagattgatt taaaacttca tttttaattt     3840

aaaaggatct aggtgaagat cctttttgat aatctcatga ccaaaatccc ttaacgtgag     3900

ttttcgttcc actgagcgtc agaccccgta gaaaagatca aaggatcttc ttgagatcct     3960

ttttttctgc gcgtaatctg ctgcttgcaa acaaaaaaac caccgctacc agcggtggtt     4020

tgtttgccgg atcaagagct accaactctt tttccgaagg taactggctt cagcagagcg     4080

cagataccaa atactgttct tctagtgtag ccgtagttag gccaccactt caagaactct     4140

gtagcaccgc ctacatacct cgctctgcta atcctgttac cagtggctgc tgccagtggc     4200

gataagtcgt gtcttaccgg gttggactca agacgatagt taccggataa ggcgcagcgg     4260

tcgggctgaa cggggggttc gtgcacacag cccagcttgg agcgaacgac ctacaccgaa     4320

ctgagatacc tacagcgtga gctatgagaa agcgccacgc ttcccgaagg gagaaaggcg     4380

gacaggtatc cggtaagcgg cagggtcgga acaggagagc gcacgaggga gcttccaggg     4440

ggaaacgcct ggtatcttta tagtcctgtc gggtttcgcc acctctgact tgagcgtcga     4500

tttttgtgat gctcgtcagg ggggcggagc ctatggaaaa acgccagcaa cgcggccttt     4560

ttacggttcc tggccttttg ctggcctttt gctcacatgt tctttcctgc gttatcccct     4620

gattctgtgg ataaccgtat taccgccttt gagtgagctg ataccgctcg ccgcagccga     4680

acgaccgagc gcagcgagtc agtgagcgag gaagcggaag agcgcccttt gagtgagctg     4740

ataccgctcg ccgcagccga acgaccgagc gcagcgagtc agtgagcgag gaagcggaag     4800

agcgcccaat acgcaaaccg cctctccccg cgcgttggcc gattcattaa tgcagctggc     4860

acgacaggtt tcccgactgg aaagcgggca gtgagcgcaa cgcaaaatgt gagttagctc     4920

actcattagg caccccaggc tttacacttt atgcttccgg ctcgtatgtt gtgtggaatt     4980

gtgagcggat aacaatttca cacaggaaac agctatgacc atgattacgc caagcgcgca     5040

attaaccctc actaaaggga acaaaagctg gagctgcaag cttaatgtag tcttatgcaa     5100

tactcttgta gtcttgcaac atggtaacga tgagttagca acatgcctta caaggagaga     5160

aaaagcaccg tgcatgccga ttggtggaag taaggtggta cgatcgtgcc ttattaggaa     5220

ggcaacagac gggtctgaca tggattggac gaaccactga attgccgcat tgcagagata     5280

ttgtatttaa gtgcctagct cgatacataa acgggtctct ctggttagac cagatctgag     5340

cctgggagct ctctggctaa ctagggaacc cactgcttaa gcctcaataa agcttgcctt     5400

gagtgcttca agtagtgtgt gcccgtctgt tgtgtgactc tggtaactag agatccctca     5460

gaccctttta gtcagtgtgg aaaatctcta gcagtggcgc ccgaacaggg acttgaaagc     5520

gaaagggaaa ccagaggagc tctctcgacg caggactcgg cttgctgaag cgcgcacggc     5580

aagaggcgag gggcggcgac tggtgagtac gccaaaaatt ttgactagcg gaggctagaa     5640

ggagagagat gggtgcgaga gcgtcagtat taagcggggg agaattagat cgcgatggga     5700

aaaaattcgg ttaaggccag ggggaaagaa aaaatataaa ttaaaacata tagtatgggc     5760

aagcagggag ctagaacgat tcgcagttaa tcctggcctg ttagaaacat cagaaggctg     5820

tagacaaata ctgggacagc tacaaccatc ccttcagaca ggatcagaag aacttagatc     5880

attatataat acagtagcaa ccctctattg tgtgcatcaa aggatagaga taaaagacac     5940

caaggaagct ttagacaaga tagaggaaga gcaaaacaaa agtaagacca ccgcacagca     6000

agcggccgct gatcttcaga cctggaggag gagatatgag ggacaattgg agaagtgaat     6060

tatataaata taaagtagta aaaattgaac cattaggagt agcacccacc aaggcaaaga     6120

gaagagtggt gcagagagaa aaaagagcag tgggaatagg agctttgttc cttgggttct     6180

tgggagcagc aggaagcact atgggcgcag cgtcaatgac gctgacggta caggccagac     6240

aattattgtc tggtatagtg cagcagcaga acaatttgct gagggctatt gaggcgcaac     6300

agcatctgtt gcaactcaca gtctggggca tcaagcagct ccaggcaaga atcctggctg     6360

tggaaagata cctaaaggat caacagctcc tggggatttg gggttgctct ggaaaactca     6420

tttgcaccac tgctgtgcct tggaatgcta gttggagtaa taaatctctg gaacagattt     6480

ggaatcacac gacctggatg gagtgggaca gagaaattaa caattacaca agcttaatac     6540

actccttaat tgaagaatcg caaaaccagc aagaaaagaa tgaacaagaa ttattggaat     6600

tagataaatg ggcaagtttg tggaattggt ttaacataac aaattggctg tggtatataa     6660

aattattcat aatgatagta ggaggcttgg taggtttaag aatagttttt gctgtacttt     6720

ctatagtgaa tagagttagg cagggatatt caccattatc gtttcagacc cacctcccaa     6780

ccccgagggg acccgacagg cccgaaggaa tagaagaaga aggtggagag agagacagag     6840

acagatccat tcgattagtg aacggatctc gacggtatcg atcacgagac tagcctcgag     6900

cggccgcccc cttcaccgag ggcctatttc ccatgattcc ttcatatttg catatacgat     6960

acaaggctgt tagagagata attggaatta atttgactgt aaacacaaag atattagtac     7020

aaaatacgtg acgtagaaag taataatttc ttgggtagtt tgcagtttta aaattatgtt     7080

ttaaaatgga ctatcatatg cttaccgtaa cttgaaagta tttcgatttc ttggctttat     7140

atatcttgtg gaaaggacga aacaccggta tctatacatt gaatcaatat tggcaattag     7200

ccatattagt cattggttat atagcataaa tcaatattgg ctattggcca ttgcatacgt     7260

tgtatctata tcataatatg tacatttata ttggctcatg tccaatatga ccgccatgtt     7320

gacattgatt attgactagt tattaatagt aatcaattac ggggtcatta gttcatagcc     7380

catatatgga gttccgcgtt acataactta cggtaaatgg cccgcctggc tgaccgccca     7440

acgacccccg cccattgacg tcaataatga cgtatgttcc catagtaacg ccaataggga     7500

ctttccattg acgtcaatgg gtggagtatt tacggtaaac tgcccacttg gcagtacatc     7560

aagtgtatca tatgccaagt ccgcccccta ttgacgtcaa tgacggtaaa tggcccgcct     7620

ggcattatgc ccagtacatg accttacggg actttcctac ttggcagtac atctacgtat     7680

tagtcatcgc tattaccatg gtgatgcggt tttggcagta catcaatggg cgtggatagc     7740

ggtttgactc acggggattt ccaagtctcc accccattga cgtcaatggg agtttgtttt     7800

ggcaccaaaa tcaacgggac tttccaaaat gtcgtaacaa ctccgcccca ttgacgcaaa     7860

tgggcggtag gcgtgtacgg tgggaggtct atataagcag agctcgttta gtgaaccgtc     7920

agatcgcctg gagacgccat ccacgctgtt ttgacctcca tagaagattc tagaaccatg     7980

gtgagcaagg gcgaggagct gttcaccggg gtggtgccca tcctggtcga gctggacggc     8040

gacgtaaacg gccacaagtt cagcgtgtcc ggcgagggcg agggcgatgc cacctacggc     8100

aagctgaccc tgaagttcat ctgcaccacc ggcaagctgc ccgtgccctg gcccaccctc     8160

gtgaccaccc tgacctacgg cgtgcagtgc ttcagccgct accccgacca catgaagcag     8220

cacgacttct tcaagtccgc catgcccgaa ggctacgtcc aggagcgcac catcttcttc     8280

aaggacgacg gcaactacaa gacccgcgcc gaggtgaagt tcgagggcga caccctggtg     8340

aaccgcatcg agctgaaggg catcgacttc aaggaggacg gcaacatcct ggggcacaag     8400

ctggagtaca actacaacag ccacaacgtc tatatcatgg ccgacaagca gaagaacggc     8460

atcaaggtga acttcaagat ccgccacaac atcgaggacg gcagcgtgca gctcgccgac     8520

cactaccagc agaacacccc catcggcgac ggccccgtgc tgctgcccga caaccactac     8580

ctgagcaccc agtccgccct gagcaaagac cccaacgaga agcgcgatca catggtcctg     8640

ctggagttcg tgaccgccgc cgggatcact ctcggcatgg acgagctgta caaggttcgc     8700

gaggttcgaa ccatgaagga cttctcagat gtcatcctct gcatggaggc aacagaatcg     8760

agcaagaccg agttctgcaa tcctgccttc gagcctgagt ctgggccacc ctgccctccc     8820

ccagttttcc cagaggatgc cagctacagc gtcccagctc cctggcatgg tcggcgtcct     8880

cgagggctac ggccagactg ccgcttctcc tggctctgtg tcctcctgct ctccagcctg     8940

ctcctcctgc tgcttgggct gctggtggcc atcatcctgg cccagctgca ggctgcaccc     9000

ccatctgggg cgtcccatag cccactgcct gccggaggcc ttaccacgac caccaccacc     9060

cccaccatca ccacctctca ggcagctggg acccctaaag ggcagcagga gtcaggcgtg     9120

agcccctccc cacagtccac ctgtggaggc ctcctctctg gcccaagggg cttcttcagc     9180

agccctaact acccagaccc ttaccccccc aacacccact gcgtgtggca tatccaggtg     9240

gccacagacc atgcaataca gctcaagatc gaagccctca gcatagagag tgtggcctct     9300

tgcctttttg atcgcttgga actctcccct gagcctgaag gccccctcct cagggtttgt     9360

ggaagggtgc ctccccccac gctcaacacc aatgccagcc acctcctggt ggtcttcgtc     9420

tctgacagca gtgtggaagg atttggtttc catgcctggt accaggctat ggcccctggg     9480

cgcgggagct gtgcccatga tgagttccgc tgtgaccagc tcatctgcct gctacctgac     9540

tcagtgtgtg atggttttgc caactgtgct gacggcagtg atgagaccaa ttgcagtgcc     9600

aagttctcgg ggtgtggggg gaatctgact ggcctccagg gcactttctc tactcccagc     9660

tacctgcagc agtaccctca ccaactgctc tgcacctggc atatctcggt gcctgccgga     9720

cacagcatag aactacagtt ccacaacttc agcctggagg ctcaggacga gtgcaagttt     9780

gactacgtgg aggtgtatga gaccagcagc tcaggggcct tcagcctcct gggcaggttc     9840

tgtggagcag agccaccccc ccacctcgtc tcctcgcacc atgagctggc tgtgctgttt     9900

aggacagatc atggcatcag cagtggaggc ttctcagcca cctacctggc cttcaatgcc     9960

acggagaacc cctgtgggcc cagtgagctc tcctgccagg caggagggtg taagggtgtg    10020

cagtggatgt gtgacatgtg gagagactgc accgatggca gcgatgacaa ctgcagcggc    10080

cccttgttcc cacccccaga gctggcctgt gagcctgtcc aggtggagat gtgcctcggt    10140

ctgagctaca acaccacagc cttccctaac atctgggtgg gcatgatcac ccaggaggag    10200

gtggtagagg tcctcagcgg ttacaagagc ctgacaagcc tgccctgcta ccagcatttc    10260

cggaggctcc tgtgtgggct gcttgtgccc cgttgcaccc cactaggcag tgttctgccc    10320

ccttgccgct ctgtctgcca ggaagcggag caccagtgcc agtctggcct ggcactactg    10380

ggcaccccct ggcccttcaa ctgcaacagg ctgccagagg cagctgacct ggaagcttgt    10440

gcccagccct agctcgagtg cggccgc                                        10467


<210> 11
<211> 9846
<212> DNA
<213> Homo sapiens

<400> 11
aacccagctt tcttgtacaa agtggttgat cgcgtgcatg cgacgtcata gctctctccc       60

aattctcgac ctcgagacaa atggcagtat tcatccacaa ttttaaaaga aaagggggga      120

ttggggggta cagtgcaggg gaaagaatag tagacataat agcaacagac atacaaacta      180

aagaattaca aaaacaaatt acaaaaattc aaaattttcg ggtttattac agggacagca      240

gagatccact ttggccgcgg ctcgaggggg ttggggttgc gccttttcca aggcagccct      300

gggtttgcgc agggacgcgg ctgctctggg cgtggttccg ggaaacgcag cggcgccgac      360

cctgggtctc gcacattctt cacgtccgtt cgcagcgtca cccggatctt cgccgctacc      420

cttgtgggcc ccccggcgac gcttcctgct ccgcccctaa gtcgggaagg ttccttgcgg      480

ttcgcggcgt gccggacgtg acaaacggaa gccgcacgtc tcactagtac cctcgcagac      540

ggacagcgcc agggagcaat ggcagcgcgc cgaccgcgat gggctgtggc caatagcggc      600

tgctcagcag ggcgcgccga gagcagcggc cgggaagggg cggtgcggga ggcggggtgt      660

ggggcggtag tgtgggccct gttcctgccc gcgcggtgtt ccgcattctg caagcctccg      720

gagcgcacgt cggcagtcgg ctccctcgtt gaccgaatca ccgacctctc tccccagggg      780

gatccaccgg agcttaccat gaccgagtac aagcccacgg tgcgcctcgc cacccgcgac      840

gacgtcccca gggcggtacg caccctcgcc gccgcgttcg ccgactaccc cgccacgcgc      900

cacaccgtcg atccggaccg ccacatcgag cgggtcaccg agctgcaaga actcttcctc      960

acgcgcgtcg ggctcgacat cggcaaggtg tgggtcgcgg acgacggcgc cgcggtggcg     1020

gtctggacca cgccggagag cgtcgaagcg ggggcggtgt tcgccgagat cggcccgcgc     1080

atggccgagt tgagcggttc ccggctggcc gcgcagcaac agatggaagg cctcctggcg     1140

ccgcaccggc ccaaggagcc cgcgtggttc ctggccaccg tcggcgtctc gcccgaccac     1200

cagggcaagg gtctgggcag cgccgtcgtg ctccccggag tggaggcggc cgagcgcgcc     1260

ggggtgcccg ccttcctgga gacctccgcg ccccgcaacc tccccttcta cgagcggctc     1320

ggcttcaccg tcaccgccga cgtcgaggtg cccgaaggac cgcgcacctg gtgcatgacc     1380

cgcaagcccg gtgcctgacg cccgccccac gacccgcagc gcccgaccga aaggagcgca     1440

cgaccccatg catcggtacc tttaagacca atgacttaca aggcagctgt agatcttagc     1500

cactttttaa aagaaaaggg gggactggaa gggctaattc actcccaacg aagacaagat     1560

ctgctttttg cttgtactgg gtctctctgg ttagaccaga tctgagcctg ggagctctct     1620

ggctaactag ggaacccact gcttaagcct caataaagct tgccttgagt gcttcaagta     1680

gtgtgtgccc gtctgttgtg tgactctggt aactagagat ccctcagacc cttttagtca     1740

gtgtggaaaa tctctagcag tagtagttca tgtcatctta ttattcagta tttataactt     1800

gcaaagaaat gaatatcaga gagtgagagg aacttgttta ttgcagctta taatggttac     1860

aaataaagca atagcatcac aaatttcaca aataaagcat ttttttcact gcattctagt     1920

tgtggtttgt ccaaactcat caatgtatct tatcatgtct ggctctagct atcccgcccc     1980

taactccgcc catcccgccc ctaactccgc ccagttccgc ccattctccg ccccatggct     2040

gactaatttt ttttatttat gcagaggccg aggccgcctc ggcctctgag ctattccaga     2100

agtagtgagg aggctttttt ggaggcctag ggacgtaccc aattcgccct atagtgagtc     2160

gtattacgcg cgctcactgg ccgtcgtttt acaacgtcgt gactgggaaa accctggcgt     2220

tacccaactt aatcgccttg cagcacatcc ccctttcgcc agctggcgta atagcgaaga     2280

ggcccgcacc gatcgccctt cccaacagtt gcgcagcctg aatggcgaat gggacgcgcc     2340

ctgtagcggc gcattaagcg cggcgggtgt ggtggttacg cgcagcgtga ccgctacact     2400

tgccagcgcc ctagcgcccg ctcctttcgc tttcttccct tcctttctcg ccacgttcgc     2460

cggctttccc cgtcaagctc taaatcgggg gctcccttta gggttccgat ttagtgcttt     2520

acggcacctc gaccccaaaa aacttgatta gggtgatggt tcacgtagtg ggccatcgcc     2580

ctgatagacg gtttttcgcc ctttgacgtt ggagtccacg ttctttaata gtggactctt     2640

gttccaaact ggaacaacac tcaaccctat ctcggtctat tcttttgatt tataagggat     2700

tttgccgatt tcggcctatt ggttaaaaaa tgagctgatt taacaaaaat ttaacgcgaa     2760

ttttaacaaa atattaacgc ttacaattta ggtggcactt ttcggggaaa tgtgcgcgga     2820

acccctattt gtttattttt ctaaatacat tcaaatatgt atccgctcat gagacaataa     2880

ccctgataaa tgcttcaata atattgaaaa aggaagagta tgagtattca acatttccgt     2940

gtcgccctta ttcccttttt tgcggcattt tgccttcctg tttttgctca cccagaaacg     3000

ctggtgaaag taaaagatgc tgaagatcag ttgggtgcac gagtgggtta catcgaactg     3060

gatctcaaca gcggtaagat ccttgagagt tttcgccccg aagaacgttt tccaatgatg     3120

agcactttta aagttctgct atgtggcgcg gtattatccc gtattgacgc cgggcaagag     3180

caactcggtc gccgcataca ctattctcag aatgacttgg ttgagtactc accagtcaca     3240

gaaaagcatc ttacggatgg catgacagta agagaattat gcagtgctgc cataaccatg     3300

agtgataaca ctgcggccaa cttacttctg acaacgatcg gaggaccgaa ggagctaacc     3360

gcttttttgc acaacatggg ggatcatgta actcgccttg atcgttggga accggagctg     3420

aatgaagcca taccaaacga cgagcgtgac accacgatgc ctgtagcaat ggcaacaacg     3480

ttgcgcaaac tattaactgg cgaactactt actctagctt cccggcaaca attaatagac     3540

tggatggagg cggataaagt tgcaggacca cttctgcgct cggcccttcc ggctggctgg     3600

tttattgctg ataaatctgg agccggtgag cgtgggtctc gcggtatcat tgcagcactg     3660

gggccagatg gtaagccctc ccgtatcgta gttatctaca cgacggggag tcaggcaact     3720

atggatgaac gaaatagaca gatcgctgag ataggtgcct cactgattaa gcattggtaa     3780

ctgtcagacc aagtttactc atatatactt tagattgatt taaaacttca tttttaattt     3840

aaaaggatct aggtgaagat cctttttgat aatctcatga ccaaaatccc ttaacgtgag     3900

ttttcgttcc actgagcgtc agaccccgta gaaaagatca aaggatcttc ttgagatcct     3960

ttttttctgc gcgtaatctg ctgcttgcaa acaaaaaaac caccgctacc agcggtggtt     4020

tgtttgccgg atcaagagct accaactctt tttccgaagg taactggctt cagcagagcg     4080

cagataccaa atactgttct tctagtgtag ccgtagttag gccaccactt caagaactct     4140

gtagcaccgc ctacatacct cgctctgcta atcctgttac cagtggctgc tgccagtggc     4200

gataagtcgt gtcttaccgg gttggactca agacgatagt taccggataa ggcgcagcgg     4260

tcgggctgaa cggggggttc gtgcacacag cccagcttgg agcgaacgac ctacaccgaa     4320

ctgagatacc tacagcgtga gctatgagaa agcgccacgc ttcccgaagg gagaaaggcg     4380

gacaggtatc cggtaagcgg cagggtcgga acaggagagc gcacgaggga gcttccaggg     4440

ggaaacgcct ggtatcttta tagtcctgtc gggtttcgcc acctctgact tgagcgtcga     4500

tttttgtgat gctcgtcagg ggggcggagc ctatggaaaa acgccagcaa cgcggccttt     4560

ttacggttcc tggccttttg ctggcctttt gctcacatgt tctttcctgc gttatcccct     4620

gattctgtgg ataaccgtat taccgccttt gagtgagctg ataccgctcg ccgcagccga     4680

acgaccgagc gcagcgagtc agtgagcgag gaagcggaag agcgcccttt gagtgagctg     4740

ataccgctcg ccgcagccga acgaccgagc gcagcgagtc agtgagcgag gaagcggaag     4800

agcgcccaat acgcaaaccg cctctccccg cgcgttggcc gattcattaa tgcagctggc     4860

acgacaggtt tcccgactgg aaagcgggca gtgagcgcaa cgcaaaatgt gagttagctc     4920

actcattagg caccccaggc tttacacttt atgcttccgg ctcgtatgtt gtgtggaatt     4980

gtgagcggat aacaatttca cacaggaaac agctatgacc atgattacgc caagcgcgca     5040

attaaccctc actaaaggga acaaaagctg gagctgcaag cttaatgtag tcttatgcaa     5100

tactcttgta gtcttgcaac atggtaacga tgagttagca acatgcctta caaggagaga     5160

aaaagcaccg tgcatgccga ttggtggaag taaggtggta cgatcgtgcc ttattaggaa     5220

ggcaacagac gggtctgaca tggattggac gaaccactga attgccgcat tgcagagata     5280

ttgtatttaa gtgcctagct cgatacataa acgggtctct ctggttagac cagatctgag     5340

cctgggagct ctctggctaa ctagggaacc cactgcttaa gcctcaataa agcttgcctt     5400

gagtgcttca agtagtgtgt gcccgtctgt tgtgtgactc tggtaactag agatccctca     5460

gaccctttta gtcagtgtgg aaaatctcta gcagtggcgc ccgaacaggg acttgaaagc     5520

gaaagggaaa ccagaggagc tctctcgacg caggactcgg cttgctgaag cgcgcacggc     5580

aagaggcgag gggcggcgac tggtgagtac gccaaaaatt ttgactagcg gaggctagaa     5640

ggagagagat gggtgcgaga gcgtcagtat taagcggggg agaattagat cgcgatggga     5700

aaaaattcgg ttaaggccag ggggaaagaa aaaatataaa ttaaaacata tagtatgggc     5760

aagcagggag ctagaacgat tcgcagttaa tcctggcctg ttagaaacat cagaaggctg     5820

tagacaaata ctgggacagc tacaaccatc ccttcagaca ggatcagaag aacttagatc     5880

attatataat acagtagcaa ccctctattg tgtgcatcaa aggatagaga taaaagacac     5940

caaggaagct ttagacaaga tagaggaaga gcaaaacaaa agtaagacca ccgcacagca     6000

agcggccgct gatcttcaga cctggaggag gagatatgag ggacaattgg agaagtgaat     6060

tatataaata taaagtagta aaaattgaac cattaggagt agcacccacc aaggcaaaga     6120

gaagagtggt gcagagagaa aaaagagcag tgggaatagg agctttgttc cttgggttct     6180

tgggagcagc aggaagcact atgggcgcag cgtcaatgac gctgacggta caggccagac     6240

aattattgtc tggtatagtg cagcagcaga acaatttgct gagggctatt gaggcgcaac     6300

agcatctgtt gcaactcaca gtctggggca tcaagcagct ccaggcaaga atcctggctg     6360

tggaaagata cctaaaggat caacagctcc tggggatttg gggttgctct ggaaaactca     6420

tttgcaccac tgctgtgcct tggaatgcta gttggagtaa taaatctctg gaacagattt     6480

ggaatcacac gacctggatg gagtgggaca gagaaattaa caattacaca agcttaatac     6540

actccttaat tgaagaatcg caaaaccagc aagaaaagaa tgaacaagaa ttattggaat     6600

tagataaatg ggcaagtttg tggaattggt ttaacataac aaattggctg tggtatataa     6660

aattattcat aatgatagta ggaggcttgg taggtttaag aatagttttt gctgtacttt     6720

ctatagtgaa tagagttagg cagggatatt caccattatc gtttcagacc cacctcccaa     6780

ccccgagggg acccgacagg cccgaaggaa tagaagaaga aggtggagag agagacagag     6840

acagatccat tcgattagtg aacggatctc gacggtatcg atcacgagac tagcctcgag     6900

cggccgcccc cttcaccgag ggcctatttc ccatgattcc ttcatatttg catatacgat     6960

acaaggctgt tagagagata attggaatta atttgactgt aaacacaaag atattagtac     7020

aaaatacgtg acgtagaaag taataatttc ttgggtagtt tgcagtttta aaattatgtt     7080

ttaaaatgga ctatcatatg cttaccgtaa cttgaaagta tttcgatttc ttggctttat     7140

atatcttgtg gaaaggacga aacaccggta tctatacatt gaatcaatat tggcaattag     7200

ccatattagt cattggttat atagcataaa tcaatattgg ctattggcca ttgcatacgt     7260

tgtatctata tcataatatg tacatttata ttggctcatg tccaatatga ccgccatgtt     7320

gacattgatt attgactagt tattaatagt aatcaattac ggggtcatta gttcatagcc     7380

catatatgga gttccgcgtt acataactta cggtaaatgg cccgcctggc tgaccgccca     7440

acgacccccg cccattgacg tcaataatga cgtatgttcc catagtaacg ccaataggga     7500

ctttccattg acgtcaatgg gtggagtatt tacggtaaac tgcccacttg gcagtacatc     7560

aagtgtatca tatgccaagt ccgcccccta ttgacgtcaa tgacggtaaa tggcccgcct     7620

ggcattatgc ccagtacatg accttacggg actttcctac ttggcagtac atctacgtat     7680

tagtcatcgc tattaccatg gtgatgcggt tttggcagta catcaatggg cgtggatagc     7740

ggtttgactc acggggattt ccaagtctcc accccattga cgtcaatggg agtttgtttt     7800

ggcaccaaaa tcaacgggac tttccaaaat gtcgtaacaa ctccgcccca ttgacgcaaa     7860

tgggcggtag gcgtgtacgg tgggaggtct atataagcag agctcgttta gtgaaccgtc     7920

agatcgcctg gagacgccat ccacgctgtt ttgacctcca tagaagattc tagaaccatg     7980

gtgagcaagg gcgaggagga taacatggcc atcatcaagg agttcatgcg cttcaaggtg     8040

cacatggagg gctccgtgaa cggccacgag ttcgagatcg agggcgaggg cgagggccgc     8100

ccctacgagg gcacccagac cgccaagctg aaggtgacca agggtggccc cctgcccttc     8160

gcctgggaca tcctgtcccc tcagttcatg tacggctcca aggcctacgt gaagcacccc     8220

gccgacatcc ccgactactt gaagctgtcc ttccccgagg gcttcaagtg ggagcgcgtg     8280

atgaacttcg aggacggcgg cgtggtgacc gtgacccagg actcctccct gcaggacggc     8340

gagttcatct acaaggtgaa gctgcgcggc accaacttcc cctccgacgg ccccgtaatg     8400

cagaagaaga ccatgggctg ggaggcctcc tccgagcgga tgtaccccga ggacggcgcc     8460

ctgaagggcg agatcaagca gaggctgaag ctgaaggacg gcggccacta cgacgctgag     8520

gtcaagacca cctacaaggc caagaagccc gtgcagctgc ccggcgccta caacgtcaac     8580

atcaagttgg acatcacctc ccacaacgag gactacacca tcgtggaaca gtacgaacgc     8640

gccgagggcc gccactccac cggcggcatg gacgagctgt acaaggttcg cgaggttcga     8700

accatgtctt cccacaaagg atctgtggtg gcacagggga atggggctcc tgccagtaac     8760

agggaagctg acacggtgga actggctgaa ctgggacccc tgctagaaga gaagggcaaa     8820

cgggtaatcg ccaacccacc caaagctgaa gaagagcaaa catgcccagt gccccaggaa     8880

gaagaggagg aggtgcgggt actgacactt cccctgcaag cccaccacgc catggagaag     8940

atggaagagt ttgtgtacaa ggtctgggag ggacgttgga gggtcatccc atatgatgtg     9000

ctccctgact ggctaaagga caacgactat ctgctacatg gtcatagacc tcccatgccc     9060

tcctttcggg cttgcttcaa gagcatcttc cgcattcata cagaaactgg caacatctgg     9120

acccatctgc ttggtttcgt gctgtttctc tttttgggaa tcttgaccat gctcagacca     9180

aatatgtact tcatggcccc tctacaggag aaggtggttt ttgggatgtt ctttttgggt     9240

gcagtgctct gcctcagctt ctcctggctc tttcacaccg tctattgtca ttcagagaaa     9300

gtctctcgga ctttttccaa actggactat tcagggattg ctcttctaat tatggggagc     9360

tttgtcccct ggctctatta ttccttctac tgctccccac agccacggct catctacctc     9420

tccatcgtct gtgtcctggg catttctgcc atcattgtgg cgcagtggga ccggtttgcc     9480

actcctaagc accggcagac aagagcaggc gtgttcctgg gacttggctt gagtggcgtc     9540

gtgcccacca tgcactttac tatcgctgag ggctttgtca aggccaccac agtgggccag     9600

atgggctggt tcttcctcat ggctgtgatg tacatcactg gagctggcct ttatgctgct     9660

cgaattcctg agcgcttctt tcctggaaaa tttgacatat ggttccagtc tcatcagatt     9720

ttccatgtcc tggtggtggc agcagccttt gtccacttct atggagtctc caaccttcag     9780

gaattccgtt acggcctaga aggcggctgt actgatgaca cccttctcta gctcgagtgc     9840

ggccgc                                                                9846


<210> 12
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 12
ccgacaacca ctacctga                                                     18


<210> 13
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 13
attgtggatg aatactgcc                                                    19


<210> 14
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 14
gttcgcgagg ttcgaaccat g                                                 21


<210> 15
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 15
tagctcgagt gcggccgca                                                    19


<210> 16
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 16
cccacaacga ggactaca                                                     18


