                         SEQUENCE LISTING

<110>  Ultragenyx Pharmaceutical Inc.
       Tachikawa, Kiyoshi
       Perez-Garcia, Carlos Gustavo
       Chivukula, Padmanabh
       Bhaskaran, Hari Prakash
       Cobaugh, Christian W.
       Daugherty, Sean Christopher
 
<120>  THERAPEUTICS FOR GLYCOGEN STORAGE DISEASE TYPE III

<130>  ULPI-041/01WO 315613-2474

<150>  US 62/513,350
<151>  2017-05-31

<160>  45    

<170>  PatentIn version 3.5

<210>  1
<211>  4599
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Consensus Human AGL Coding Sequence

<400>  1
augggacaca guaaacagau ucgaauuuua cuucugaacg aaauggagaa acuggaaaag       60

acccucuuca gacuugaaca aggguaugag cuacaguucc gauuaggccc aacuuuacag      120

ggaaaagcag uuaccgugua uacaaauuac ccauuuccug gagaaacauu uaauagagaa      180

aaauuccguu cucuggauug ggaaaaucca acagaaagag aagaugauuc ugauaaauac      240

uguaaacuua aucugcaaca aucugguuca uuucaguauu auuuccuuca aggaaaugag      300

aaaaguggug gagguuacau aguuguggac cccauuuuac guguuggugc ugauaaucau      360

gugcuacccu uggacugugu uacucuucag acauuuuuag cuaaguguuu gggaccuuuu      420

gaugaauggg aaagcagacu uaggguugca aaagaaucag gcuacaacau gauucauuuu      480

accccauugc agacucuugg acuaucuagg ucaugcuacu cccuugccaa ucaguuagaa      540

uuaaauccug acuuuucaag accuaauaga aaguauaccu ggaaugaugu uggacagcua      600

guggaaaaau uaaaaaagga auggaauguu auuuguauua cugauguugu cuacaaucau      660

acugcugcua auaguaaaug gauccaggaa cauccagaau gugccuauaa ucuugugaau      720

ucuccacacu uaaaaccugc cugggucuua gacagagcac uuuggcguuu cuccugugau      780

guugcagaag ggaaauacaa agaaaaggga auaccugcuu ugauugaaaa ugaucaccau      840

augaauucca uccgaaaaau aauuugggag gauauuuuuc caaagcuuaa acucugggaa      900

uuuuuccaag uagaugucaa caaagcgguu gagcaauuua gaagacuucu uacacaagaa      960

aauaggcgag uaaccaaguc ugauccaaac caacaccuua cgauuauuca agauccugaa     1020

uacagacggu uuggcuguac uguagauaug aacauugcac uaacgacuuu cauaccacau     1080

gacaaggggc cagcagcaau ugaagaaugc uguaauuggu uucauaaaag aauggaggaa     1140

uuaaauucag agaagcaucg acucauuaac uaucaucagg aacaggcagu uaauugccuu     1200

uugggaaaug uguuuuauga acgacuggcu ggccaugguc caaaacuagg accugucacu     1260

agaaagcauc cuuuaguuac cagguauuuu acuuucccau uugaagagau agacuucucc     1320

auggaagaau cuaugauuca ucugccaaau aaagcuuguu uucugauggc acacaaugga     1380

uggguaaugg gagaugaucc ucuucgaaac uuugcugaac cggguucaga aguuuaccua     1440

aggagagaac uuauuugcug gggagacagu guuaaauuac gcuaugggaa uaaaccagag     1500

gacuguccuu aucucugggc acacaugaaa aaauacacug aaauaacugc aacuuauuuc     1560

cagggaguac gucuugauaa cugccacuca acaccucuuc acguagcuga guacauguug     1620

gaugcugcua ggaauuugca acccaauuua uauguaguag cugaacuguu cacaggaagu     1680

gaagaucugg acaaugucuu uguuacuaga cugggcauua guuccuuaau aagagaggca     1740

augagugcau auaauaguca ugaagagggc agauuaguuu accgauaugg aggagaaccu     1800

guuggauccu uuguucagcc cuguuugagg ccuuuaaugc cagcuauugc acaugcccug     1860

uuuauggaua uuacgcauga uaaugagugu ccuauugugc auagaucagc guaugaugcu     1920

cuaccaagua cuacaauugu uucuauggca uguugugcua guggaaguac aagaggcuau     1980

gaugaauuag ugccucauca gauuucagug guuucugaag aacgguuuua cacuaagugg     2040

aauccugaag cauugccuuc aaacacaggu gaaguuaauu uccaaagcgg cauuauugca     2100

gccaggugug cuaucaguaa acuucaucag gagcuuggag ccaaggguuu uauucaggug     2160

uauguggauc aaguugauga agacauagug gcaguaacaa gacacucacc uagcauccau     2220

cagucuguug uggcuguauc uagaacugcu uucaggaauc ccaagacuuc auuuuacagc     2280

aaggaagugc cucaaaugug caucccuggc aaaauugaag aaguaguucu ugaagcuaga     2340

acuauugaga gaaacacgaa accuuauagg aaggaugaga auucaaucaa uggaacacca     2400

gauaucacag uagaaauuag agaacauauu cagcuuaaug aaaguaaaau uguuaaacaa     2460

gcuggaguug ccacaaaagg gcccaaugaa uauauucaag aaauagaauu ugaaaacuug     2520

ucuccaggaa guguuauuau auucagaguu agucuugauc cacaugcaca agucgcuguu     2580

ggaauucuuc gaaaucaucu gacacaauuc aguccucacu uuaaaucugg cagccuagcu     2640

guugacaaug cagauccuau auuaaaaauu ccuuuugcuu cucuugccuc cagauuaacu     2700

uuggcugagc uaaaucagau ccuuuaccga ugugaaucag aagaaaagga agauggugga     2760

gggugcuaug acauaccaaa cuggucagcc cuuaaauaug caggucuuca agguuuaaug     2820

ucuguauugg cagaaauaag accaaagaau gacuuggggc auccuuuuug uaauaauuug     2880

agaucuggag auuggaugau ugacuauguc aguaaccggc uuauuucacg aucaggaacu     2940

auugcugaag uugguaaaug guugcaggcu auguucuucu accugaagca gaucccacgu     3000

uaccuuaucc cauguuacuu ugaugcuaua uuaauuggug cauauaccac ucuucuggau     3060

acagcaugga agcagauguc aagcuuuguu cagaaugguu caaccuuugu gaaacaccuu     3120

ucauuggguu caguucaacu guguggagua ggaaaauucc cuucccugcc aauucuuuca     3180

ccugcccuaa uggauguacc uuauagguua aaugagauca caaaagaaaa ggagcaaugu     3240

uguguuucuc uagcugcagg cuuaccucau uuuucuucug guauuuuccg cugcugggga     3300

agggauacuu uuauugcacu uagagguaua cugcugauua cuggacgcua uguagaagcc     3360

aggaauauua uuuuagcauu ugcggguacc cugaggcaug gacucauucc uaaucuacug     3420

ggugaaggaa uuuaugccag auacaauugu cgggaugcug ugugguggug gcugcagugu     3480

auccaggauu acuguaaaau gguuccaaau ggucuagaca uucucaagug cccaguuucc     3540

agaauguauc cuacagauga uucugcuccu uugccugcug gcacacugga ucagccauug     3600

uuugaaguca uacaggaagc aaugcaaaaa cacaugcagg gcauacaguu ccgagaaagg     3660

aaugcugguc cccagauaga ucgaaacaug aaggacgaag guuuuaauau aacugcagga     3720

guugaugaag aaacaggauu uguuuaugga ggaaaucguu ucaauugugg cacauggaug     3780

gauaaaaugg gagaaaguga cagagcuaga aacagaggaa ucccagccac accaagagau     3840

gggucugcug uggaaauugu gggccugagu aaaucugcug uucgcugguu gcuggaauua     3900

uccaaaaaaa auauuuuccc uuaucaugaa gucacaguaa aaagacaugg aaaggcuaua     3960

aagguaucau augaugagug gaacagaaaa auacaagaca acuuugaaaa gcuauuucau     4020

guuuccgaag acccuucaga uuuaaaugaa aagcauccaa aucugguuca caaacguggc     4080

auauacaaag auaguuaugg agcuucaagu ccuuggugug acuaucagcu caggccuaau     4140

uuuaccauag caaugguugu ggccccugag cucuuuacua cagaaaaagc auggaaagcu     4200

uuggagauug cagaaaaaaa auugcuuggu ccccuuggca ugaaaacuuu agauccagau     4260

gauaugguuu acuguggaau uuaugacaau gcauuagaca augacaacua caaucuugcu     4320

aaagguuuca auuaucacca aggaccugag uggcuguggc cuauugggua uuuucuucgu     4380

gcaaaauuau auuuuuccag auugaugggc ccggagacua cugcaaagac uauaguuuug     4440

guuaaaaaug uucuuucccg acauuauguu caucuugaga gauccccuug gaaaggacuu     4500

ccagaacuga ccaaugagaa ugcccaguac uguccuuuca gcugugaaac acaagccugg     4560

ucaauugcua cuauucuuga gacacuuuau gauuuauag                            4599


<210>  2
<211>  1532
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Consensus Human AGL Amino Acid Sequence

<400>  2

Met Gly His Ser Lys Gln Ile Arg Ile Leu Leu Leu Asn Glu Met Glu 
1               5                   10                  15      


Lys Leu Glu Lys Thr Leu Phe Arg Leu Glu Gln Gly Tyr Glu Leu Gln 
            20                  25                  30          


Phe Arg Leu Gly Pro Thr Leu Gln Gly Lys Ala Val Thr Val Tyr Thr 
        35                  40                  45              


Asn Tyr Pro Phe Pro Gly Glu Thr Phe Asn Arg Glu Lys Phe Arg Ser 
    50                  55                  60                  


Leu Asp Trp Glu Asn Pro Thr Glu Arg Glu Asp Asp Ser Asp Lys Tyr 
65                  70                  75                  80  


Cys Lys Leu Asn Leu Gln Gln Ser Gly Ser Phe Gln Tyr Tyr Phe Leu 
                85                  90                  95      


Gln Gly Asn Glu Lys Ser Gly Gly Gly Tyr Ile Val Val Asp Pro Ile 
            100                 105                 110         


Leu Arg Val Gly Ala Asp Asn His Val Leu Pro Leu Asp Cys Val Thr 
        115                 120                 125             


Leu Gln Thr Phe Leu Ala Lys Cys Leu Gly Pro Phe Asp Glu Trp Glu 
    130                 135                 140                 


Ser Arg Leu Arg Val Ala Lys Glu Ser Gly Tyr Asn Met Ile His Phe 
145                 150                 155                 160 


Thr Pro Leu Gln Thr Leu Gly Leu Ser Arg Ser Cys Tyr Ser Leu Ala 
                165                 170                 175     


Asn Gln Leu Glu Leu Asn Pro Asp Phe Ser Arg Pro Asn Arg Lys Tyr 
            180                 185                 190         


Thr Trp Asn Asp Val Gly Gln Leu Val Glu Lys Leu Lys Lys Glu Trp 
        195                 200                 205             


Asn Val Ile Cys Ile Thr Asp Val Val Tyr Asn His Thr Ala Ala Asn 
    210                 215                 220                 


Ser Lys Trp Ile Gln Glu His Pro Glu Cys Ala Tyr Asn Leu Val Asn 
225                 230                 235                 240 


Ser Pro His Leu Lys Pro Ala Trp Val Leu Asp Arg Ala Leu Trp Arg 
                245                 250                 255     


Phe Ser Cys Asp Val Ala Glu Gly Lys Tyr Lys Glu Lys Gly Ile Pro 
            260                 265                 270         


Ala Leu Ile Glu Asn Asp His His Met Asn Ser Ile Arg Lys Ile Ile 
        275                 280                 285             


Trp Glu Asp Ile Phe Pro Lys Leu Lys Leu Trp Glu Phe Phe Gln Val 
    290                 295                 300                 


Asp Val Asn Lys Ala Val Glu Gln Phe Arg Arg Leu Leu Thr Gln Glu 
305                 310                 315                 320 


Asn Arg Arg Val Thr Lys Ser Asp Pro Asn Gln His Leu Thr Ile Ile 
                325                 330                 335     


Gln Asp Pro Glu Tyr Arg Arg Phe Gly Cys Thr Val Asp Met Asn Ile 
            340                 345                 350         


Ala Leu Thr Thr Phe Ile Pro His Asp Lys Gly Pro Ala Ala Ile Glu 
        355                 360                 365             


Glu Cys Cys Asn Trp Phe His Lys Arg Met Glu Glu Leu Asn Ser Glu 
    370                 375                 380                 


Lys His Arg Leu Ile Asn Tyr His Gln Glu Gln Ala Val Asn Cys Leu 
385                 390                 395                 400 


Leu Gly Asn Val Phe Tyr Glu Arg Leu Ala Gly His Gly Pro Lys Leu 
                405                 410                 415     


Gly Pro Val Thr Arg Lys His Pro Leu Val Thr Arg Tyr Phe Thr Phe 
            420                 425                 430         


Pro Phe Glu Glu Ile Asp Phe Ser Met Glu Glu Ser Met Ile His Leu 
        435                 440                 445             


Pro Asn Lys Ala Cys Phe Leu Met Ala His Asn Gly Trp Val Met Gly 
    450                 455                 460                 


Asp Asp Pro Leu Arg Asn Phe Ala Glu Pro Gly Ser Glu Val Tyr Leu 
465                 470                 475                 480 


Arg Arg Glu Leu Ile Cys Trp Gly Asp Ser Val Lys Leu Arg Tyr Gly 
                485                 490                 495     


Asn Lys Pro Glu Asp Cys Pro Tyr Leu Trp Ala His Met Lys Lys Tyr 
            500                 505                 510         


Thr Glu Ile Thr Ala Thr Tyr Phe Gln Gly Val Arg Leu Asp Asn Cys 
        515                 520                 525             


His Ser Thr Pro Leu His Val Ala Glu Tyr Met Leu Asp Ala Ala Arg 
    530                 535                 540                 


Asn Leu Gln Pro Asn Leu Tyr Val Val Ala Glu Leu Phe Thr Gly Ser 
545                 550                 555                 560 


Glu Asp Leu Asp Asn Val Phe Val Thr Arg Leu Gly Ile Ser Ser Leu 
                565                 570                 575     


Ile Arg Glu Ala Met Ser Ala Tyr Asn Ser His Glu Glu Gly Arg Leu 
            580                 585                 590         


Val Tyr Arg Tyr Gly Gly Glu Pro Val Gly Ser Phe Val Gln Pro Cys 
        595                 600                 605             


Leu Arg Pro Leu Met Pro Ala Ile Ala His Ala Leu Phe Met Asp Ile 
    610                 615                 620                 


Thr His Asp Asn Glu Cys Pro Ile Val His Arg Ser Ala Tyr Asp Ala 
625                 630                 635                 640 


Leu Pro Ser Thr Thr Ile Val Ser Met Ala Cys Cys Ala Ser Gly Ser 
                645                 650                 655     


Thr Arg Gly Tyr Asp Glu Leu Val Pro His Gln Ile Ser Val Val Ser 
            660                 665                 670         


Glu Glu Arg Phe Tyr Thr Lys Trp Asn Pro Glu Ala Leu Pro Ser Asn 
        675                 680                 685             


Thr Gly Glu Val Asn Phe Gln Ser Gly Ile Ile Ala Ala Arg Cys Ala 
    690                 695                 700                 


Ile Ser Lys Leu His Gln Glu Leu Gly Ala Lys Gly Phe Ile Gln Val 
705                 710                 715                 720 


Tyr Val Asp Gln Val Asp Glu Asp Ile Val Ala Val Thr Arg His Ser 
                725                 730                 735     


Pro Ser Ile His Gln Ser Val Val Ala Val Ser Arg Thr Ala Phe Arg 
            740                 745                 750         


Asn Pro Lys Thr Ser Phe Tyr Ser Lys Glu Val Pro Gln Met Cys Ile 
        755                 760                 765             


Pro Gly Lys Ile Glu Glu Val Val Leu Glu Ala Arg Thr Ile Glu Arg 
    770                 775                 780                 


Asn Thr Lys Pro Tyr Arg Lys Asp Glu Asn Ser Ile Asn Gly Thr Pro 
785                 790                 795                 800 


Asp Ile Thr Val Glu Ile Arg Glu His Ile Gln Leu Asn Glu Ser Lys 
                805                 810                 815     


Ile Val Lys Gln Ala Gly Val Ala Thr Lys Gly Pro Asn Glu Tyr Ile 
            820                 825                 830         


Gln Glu Ile Glu Phe Glu Asn Leu Ser Pro Gly Ser Val Ile Ile Phe 
        835                 840                 845             


Arg Val Ser Leu Asp Pro His Ala Gln Val Ala Val Gly Ile Leu Arg 
    850                 855                 860                 


Asn His Leu Thr Gln Phe Ser Pro His Phe Lys Ser Gly Ser Leu Ala 
865                 870                 875                 880 


Val Asp Asn Ala Asp Pro Ile Leu Lys Ile Pro Phe Ala Ser Leu Ala 
                885                 890                 895     


Ser Arg Leu Thr Leu Ala Glu Leu Asn Gln Ile Leu Tyr Arg Cys Glu 
            900                 905                 910         


Ser Glu Glu Lys Glu Asp Gly Gly Gly Cys Tyr Asp Ile Pro Asn Trp 
        915                 920                 925             


Ser Ala Leu Lys Tyr Ala Gly Leu Gln Gly Leu Met Ser Val Leu Ala 
    930                 935                 940                 


Glu Ile Arg Pro Lys Asn Asp Leu Gly His Pro Phe Cys Asn Asn Leu 
945                 950                 955                 960 


Arg Ser Gly Asp Trp Met Ile Asp Tyr Val Ser Asn Arg Leu Ile Ser 
                965                 970                 975     


Arg Ser Gly Thr Ile Ala Glu Val Gly Lys Trp Leu Gln Ala Met Phe 
            980                 985                 990         


Phe Tyr Leu Lys Gln Ile Pro Arg  Tyr Leu Ile Pro Cys  Tyr Phe Asp 
        995                 1000                 1005             


Ala Ile  Leu Ile Gly Ala Tyr  Thr Thr Leu Leu Asp  Thr Ala Trp 
    1010                 1015                 1020             


Lys Gln  Met Ser Ser Phe Val  Gln Asn Gly Ser Thr  Phe Val Lys 
    1025                 1030                 1035             


His Leu  Ser Leu Gly Ser Val  Gln Leu Cys Gly Val  Gly Lys Phe 
    1040                 1045                 1050             


Pro Ser  Leu Pro Ile Leu Ser  Pro Ala Leu Met Asp  Val Pro Tyr 
    1055                 1060                 1065             


Arg Leu  Asn Glu Ile Thr Lys  Glu Lys Glu Gln Cys  Cys Val Ser 
    1070                 1075                 1080             


Leu Ala  Ala Gly Leu Pro His  Phe Ser Ser Gly Ile  Phe Arg Cys 
    1085                 1090                 1095             


Trp Gly  Arg Asp Thr Phe Ile  Ala Leu Arg Gly Ile  Leu Leu Ile 
    1100                 1105                 1110             


Thr Gly  Arg Tyr Val Glu Ala  Arg Asn Ile Ile Leu  Ala Phe Ala 
    1115                 1120                 1125             


Gly Thr  Leu Arg His Gly Leu  Ile Pro Asn Leu Leu  Gly Glu Gly 
    1130                 1135                 1140             


Ile Tyr  Ala Arg Tyr Asn Cys  Arg Asp Ala Val Trp  Trp Trp Leu 
    1145                 1150                 1155             


Gln Cys  Ile Gln Asp Tyr Cys  Lys Met Val Pro Asn  Gly Leu Asp 
    1160                 1165                 1170             


Ile Leu  Lys Cys Pro Val Ser  Arg Met Tyr Pro Thr  Asp Asp Ser 
    1175                 1180                 1185             


Ala Pro  Leu Pro Ala Gly Thr  Leu Asp Gln Pro Leu  Phe Glu Val 
    1190                 1195                 1200             


Ile Gln  Glu Ala Met Gln Lys  His Met Gln Gly Ile  Gln Phe Arg 
    1205                 1210                 1215             


Glu Arg  Asn Ala Gly Pro Gln  Ile Asp Arg Asn Met  Lys Asp Glu 
    1220                 1225                 1230             


Gly Phe  Asn Ile Thr Ala Gly  Val Asp Glu Glu Thr  Gly Phe Val 
    1235                 1240                 1245             


Tyr Gly  Gly Asn Arg Phe Asn  Cys Gly Thr Trp Met  Asp Lys Met 
    1250                 1255                 1260             


Gly Glu  Ser Asp Arg Ala Arg  Asn Arg Gly Ile Pro  Ala Thr Pro 
    1265                 1270                 1275             


Arg Asp  Gly Ser Ala Val Glu  Ile Val Gly Leu Ser  Lys Ser Ala 
    1280                 1285                 1290             


Val Arg  Trp Leu Leu Glu Leu  Ser Lys Lys Asn Ile  Phe Pro Tyr 
    1295                 1300                 1305             


His Glu  Val Thr Val Lys Arg  His Gly Lys Ala Ile  Lys Val Ser 
    1310                 1315                 1320             


Tyr Asp  Glu Trp Asn Arg Lys  Ile Gln Asp Asn Phe  Glu Lys Leu 
    1325                 1330                 1335             


Phe His  Val Ser Glu Asp Pro  Ser Asp Leu Asn Glu  Lys His Pro 
    1340                 1345                 1350             


Asn Leu  Val His Lys Arg Gly  Ile Tyr Lys Asp Ser  Tyr Gly Ala 
    1355                 1360                 1365             


Ser Ser  Pro Trp Cys Asp Tyr  Gln Leu Arg Pro Asn  Phe Thr Ile 
    1370                 1375                 1380             


Ala Met  Val Val Ala Pro Glu  Leu Phe Thr Thr Glu  Lys Ala Trp 
    1385                 1390                 1395             


Lys Ala  Leu Glu Ile Ala Glu  Lys Lys Leu Leu Gly  Pro Leu Gly 
    1400                 1405                 1410             


Met Lys  Thr Leu Asp Pro Asp  Asp Met Val Tyr Cys  Gly Ile Tyr 
    1415                 1420                 1425             


Asp Asn  Ala Leu Asp Asn Asp  Asn Tyr Asn Leu Ala  Lys Gly Phe 
    1430                 1435                 1440             


Asn Tyr  His Gln Gly Pro Glu  Trp Leu Trp Pro Ile  Gly Tyr Phe 
    1445                 1450                 1455             


Leu Arg  Ala Lys Leu Tyr Phe  Ser Arg Leu Met Gly  Pro Glu Thr 
    1460                 1465                 1470             


Thr Ala  Lys Thr Ile Val Leu  Val Lys Asn Val Leu  Ser Arg His 
    1475                 1480                 1485             


Tyr Val  His Leu Glu Arg Ser  Pro Trp Lys Gly Leu  Pro Glu Leu 
    1490                 1495                 1500             


Thr Asn  Glu Asn Ala Gln Tyr  Cys Pro Phe Ser Cys  Glu Thr Gln 
    1505                 1510                 1515             


Ala Trp  Ser Ile Ala Thr Ile  Leu Glu Thr Leu Tyr  Asp Leu 
    1520                 1525                 1530         


<210>  3
<211>  129
<212>  RNA
<213>  Tobacco Etch Virus

<400>  3
ucaacacaac auauacaaaa caaacgaauc ucaagcaauc aagcauucua cuucuauugc       60

agcaauuuaa aucauuucuu uuaaagcaaa agcaauuuuc ugaaaauuuu caccauuuac      120

gaacgauag                                                              129


<210>  4
<211>  6
<212>  RNA
<213>  Unknown

<220>
<223>  Kozak Sequence

<400>  4
gccacc                                                                   6


<210>  5
<211>  158
<212>  RNA
<213>  Xenopus sp.

<400>  5
cuagugacug acuaggaucu gguuaccacu aaaccagccu caagaacacc cgaauggagu       60

cucuaagcua cauaauacca acuuacacuu acaaaauguu gucccccaaa auguagccau      120

ucguaucugc uccuaauaaa aagaaaguuu cuucacau                              158


<210>  6
<211>  114
<212>  RNA
<213>  Unknown

<220>
<223>  Poly(A) 114 Tail

<400>  6
aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa       60

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaa            114


<210>  7
<211>  4599
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Codon-Optimized AGL Coding Sequence

<400>  7
augggacacu ccaaacagau ccggauacug cugcugaacg agauggaaaa gcuggaaaag       60

acucuauucc ggcucgagca gggauacgag cugcaguucc gccugggccc cacccuacaa      120

gggaaggccg ugaccgucua caccaacuac ccuuucccgg gcgaaacuuu caaccgggag      180

aaguuccggu cccuugacug ggaaaacccg acugagcgcg aggacgacuc ggacaaauac      240

ugcaagcuga accuccagca gucgggcucu uuccaauauu acuucuugca agggaacgag      300

aaguccggug gcggcuacau cgugguggac ccaauuuugc gcgugggggc ugacaaccac      360

gugcugccac uggauugugu gacccugcaa accuuccugg ccaagugccu cggccccuuc      420

gacgaauggg agucgcgccu gagaguggcg aaagagagcg gauacaacau gauucacuuc      480

acgccgcucc aaacgcuggg ucugagccgg ucaugcuacu cacuggcgaa ccagcucgaa      540

cugaaccccg auuucucccg gccaaacagg aaguacaccu ggaacgacgu gggacagcug      600

gucgagaagu ugaagaagga guggaacgug aucuguauca ccgacgucgu guacaaccac      660

accgcugcaa acucgaagug gauccaggaa cauccggaau gugccuacaa ccucgugaac      720

agcccgcacc ugaagccugc cuggguguug gauagggcac uguggagguu cuccugugac      780

guggcagagg gaaaguacaa ggagaagggu auucccgcac ucaucgaaaa cgaucaccac      840

augaauucga ucagaaagau uaucugggag gauaucuucc cuaagcugaa gcugugggag      900

uucuuucaag uugaugugaa caaggcaguc gaacaguuuc ggcggcuguu aacccaagaa      960

aaccgccgcg ugaccaaguc cgauccgaau cagcaucuga ccauaaucca ggacccggaa     1020

uaccgccggu uuggcugcac cguggacaug aacauugccc ugacuaccuu uaucccgcau     1080

gauaagggcc ccgccgcuau cgaagaaugc ugcaacuggu uccacaagag gauggaggaa     1140

cugaacuccg aaaagcauag gcucauuaac uaccaccagg aacaggcagu gaacugccug     1200

cuggggaacg uguucuacga gcgacuggcu ggacacggac cgaaguuagg acccgugaca     1260

aggaagcacc cacuggucac uagauacuuc accuucccau uugaggaaau cgacuucuca     1320

auggaggagu cgaugaucca cuugccuaac aaggccugcu uucucauggc acauaacgga     1380

ugggucaugg gcgacgaucc ccuacggaau uuugcagaac caggcagcga ggucuaccuu     1440

cggcgggaac ugauuugcug gggcgacucc gucaagcugc gcuacggcaa caagccugag     1500

gacugucccu accuuugggc acacaugaag aaguacacug aaauuacugc gacauacuuc     1560

caaggagucc gcuuagauaa uugucacucc accccgcugc auguggcgga guacaugcug     1620

gaugccgcaa gaaaccucca gccgaaucuc uacgugguag cagagcuguu caccgggagc     1680

gaggaccugg acaauguguu ugucacccgg cuggggaucu ccucccugau ccgggaggcc     1740

auguccgccu acaacucaca cgaggagggg agacuggugu accgcuacgg aggagaaccc     1800

gugggcagcu uugugcagcc uugccuccgg ccgcugaugc ccgcgauugc gcaugcucug     1860

uucauggaua ucacucacga uaacgagugc cccauugugc acagauccgc cuacgacgcc     1920

cuuccuucca caaccaucgu guccauggca ugcugcgccu ccggcuccac ucgggguuac     1980

gaugagcugg ugccacacca gauuuccgug guguccgaag aacgcuucua caccaagugg     2040

aacccggaag cucugccguc aaacaccgga gaagugaacu uccaguccgg gaucaucgca     2100

gcgcgcugug cuauuagcaa gcugcaccag gagcugggag ccaagggguu cauccagguc     2160

uauguggacc aggucgauga ggauaucguc gcugucacga gacacagccc gucuauccau     2220

caaagcgucg uggccguguc ccggacugcg uuccggaacc cuaaaaccuc auucuauucc     2280

aaagaggugc cccagaugug caucccugga aagaucgaag aagucgugcu ggaagcccgg     2340

accaucgagc ggaacaccaa gccguacagg aaggacgaaa acuccaucaa ugguaccccu     2400

gacauuaccg uggaaaucag agaacauauc cagcugaacg aguccaagau cgugaagcag     2460

gccggcgugg cgaccaaggg ucccaacgag uacauucagg aaaucgaguu ugaaaaccug     2520

ucccccggaa gcgugaucau uuuccgggug ucccuggacc cgcaugcgca agucgcuguc     2580

ggaauucugc ggaaucaccu cacccaauuc ucgccgcauu ucaagagugg uucccuggcg     2640

guggauaaug ccgauccgau ccugaagauu cccuucgcgu cccuggcauc gagacucacc     2700

cuggcggagu ugaaccagau ucuguaccgc ugcgaauccg aggaaaagga ggacggaggc     2760

gguugcuacg acauccccaa cugguccgca cuuaaguacg cagggcugca gggucuuaug     2820

agcgugcugg cagaaauucg cccuaagaac gauuugggac accccuucug caacaaccuc     2880

cgguccggag acuggaugau cgauuacgug ucgaacagac ugauuucgag auccggcacc     2940

auugccgagg ucggaaagug gcuucaggcc auguucuucu accugaagca gaucccgaga     3000

uaccugauuc ccugcuacuu cgacgcaauc cugaucgggg cguauaccac ucuucuggac     3060

acugccugga agcagauguc cagcuucgug caaaacggau ccaccuucgu caagcaucuu     3120

agccugggcu cagugcaguu gugcggagug ggaaaauucc cuagccuccc uauucuuuca     3180

ccggcgcuga uggacgugcc uuaccgccug aacgaaauca ccaaagagaa ggagcagugu     3240

ugcgugucgc uggccgcggg ucugccgcau uucuccuccg gcaucuuccg gugcugggga     3300

agggacaccu ucaucgcucu gaggggaauc cugcugauua ccgggcgcua cguggaagcu     3360

cggaacauca uccuggccuu cgcgggaacu cugcgccacg gccugauucc aaacuugcuu     3420

ggcgaaggca ucuacgcgcg cuacaacugc cgcgacgcgg ucugguggug gcuccagugc     3480

auucaagacu acugcaagau ggugccaaac ggccuggaca uccugaagug cccggugucg     3540

agaauguacc ccaccgacga uucugcgccc cugccggccg guacucuuga ccaaccucug     3600

uucgaaguga uccaggaagc aaugcagaag cacaugcagg gcauucaguu ccgggagcgc     3660

aacgcagggc cgcaaaucga caggaacaug aaggacgaag gauucaacau caccgcggga     3720

guggacgaag agacuggcuu cgucuacggu ggaaaucggu ucaacugcgg gaccuggaug     3780

gacaagaugg gcgaaucaga ccgagcccgc aaccgcggaa ucccugccac cccccgggau     3840

gggagcgccg uggagauugu gggacugagc aagagcgcug ugcgcuggcu gcuggaguug     3900

agcaagaaga acauuuuccc cuaucacgaa gugaccguga agcggcacgg aaaagcuauc     3960

aaaguguccu acgacgagug gaacagaaag auccaggaca acuucgagaa gcuguuccac     4020

guguccgagg acccgucgga cuugaaugag aagcacccua accucgugca caagcgggga     4080

aucuacaagg acagcuacgg agcauccucg ccuuggugcg acuaucagcu gaggcccaac     4140

uucacuaucg caaugguggu ggccccagaa cuguucacua ccgaaaaggc cuggaaggca     4200

cuggagaucg cagagaaaaa gcugcugggc ccucugggca ugaaaacccu ggaccccgac     4260

gacauggugu acugcgggau cuacgauaac gcucuugaca augacaacua caaccuggcu     4320

aagggauuca acuaucacca gggccccgag uggcuguggc cgaucgguua cuuccugcgc     4380

gccaagcugu acuuuucccg gcugaugggc ccugagacua ccgcaaagac gaucgugcug     4440

gucaagaacg ugcugucacg gcacuacgug caucuggaac ggagcccgug gaagggguug     4500

cccgaacuga ccaacgaaaa cgcgcaguac uguccguucu cgugcgaaac ucaggccugg     4560

uccaucgcca cuauccucga aacucucuac gaccuguag                            4599


<210>  8
<211>  4599
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Codon-Optimized AGL Coding Sequence

<400>  8
augggacaua gcaaacaaau uaggauccuc cugcugaacg aaauggaaaa acuggaaaag       60

acgcuguuuc ggcuggaaca gggcuacgaa cuccaguuuc gccucgggcc aacgcugcaa      120

gggaaagcag ugaccgugua uacaaacuac ccauucccug gagagacauu caauagggag      180

aaguuuagaa gcuuagacug ggaaaaucca accgaacgag aagaugacag cgauaaguau      240

ugcaagcuga aucugcaaca guccggaagu uuucaguacu acuuuuugca agggaacgaa      300

aagagcggcg gagguuauau ugugguggau ccaauuuuga gaguuggggc cgacaaccau      360

guacugccuc uugacugugu gacacugcaa acguuccugg ccaagugccu gggcccguuu      420

gaugaguggg aaagccguuu gcgcguggcc aaggaauccg gguacaacau gauccauuuu      480

accccacugc aaaccuuagg ccugucaagg agcuguuaca gucuggccaa ccagcuggaa      540

cugaaucccg acuucucccg gccaaauagg aaguacacgu ggaacgacgu uggccagcua      600

guggagaagu ugaagaagga guggaacguu auuugcauca cugacgucgu guauaaucac      660

acugccgcua auagcaaaug gauccaggaa cauccagagu gugccuauaa ccuggucaac      720

agcccgcauc ugaagccagc augggugcug gaccgggcgu uguggcgguu cucgugugac      780

guggccgaag gaaaguauaa ggagaagggu auuccggcuc ugauagagaa cgaccaucau      840

augaauucca ucaggaagau cauuugggag gacaucuuuc caaaguugaa gcugugggag      900

uucuuucaag uggaugugaa caaggccgua gaacaguuuc gccgccuacu aacccaggaa      960

aauaggagag ucacaaaguc cgaucccaac caacaucuga ccauaauuca ggaccccgaa     1020

uaucgucgau uuggcugcac cguggauaug aacaucgcuu ugacaacuuu cauaccacac     1080

gacaaggguc cagccgccau ugaagagugu uguaacuggu uucacaaacg aauggaggag     1140

uugaacagug aaaagcaccg ccugaucaau uaucaucagg agcaggccgu gaacuguuug     1200

cuggggaaug uguucuauga gaggcucgcu ggucauggcc cuaagcuggg uccuguaaca     1260

agaaagcauc cauuagugac gcgcuacuuu acauucccau uugaggagau cgacuuuucg     1320

auggaagagu ccaugauuca ucuccccaac aaggccuguu uucugauggc ccacaacggc     1380

uggguuaugg gggaugaucc guugagaaau uuugcggaac cagguucaga aguguaucug     1440

cgucgggagc ugauuuguug gggcgacucc gugaagcucc gcuaugggaa caagccugag     1500

gauuguccuu aucugugggc gcauaugaag aaguauacag agaucacugc cacauauuuu     1560

cagggcguca ggcuggacaa uugucauagc accccgcuuc auguggcuga guauaugcug     1620

gacgcagcaa ggaaucugca gcccaaucug uauguggugg cggaacuguu uaccgggucc     1680

gaggaccugg acaauguauu uguaacccga uugggcaucu ccagccugau uagggaagca     1740

augagugcau acaacucaca cgaggagggg cggcugguuu aucgauaugg gggggaaccu     1800

gugggcagcu uuguacagcc augucuccgg ccguugaugc cugccauugc ucaugcgcuc     1860

uuuauggaua uaacacauga caacgaaugu ccaaucguuc auaggagugc uuacgacgcc     1920

cugccgagca caacgaucgu guccauggcc uguugugcaa guggcagcac acguggcuau     1980

gacgaauugg uaccccacca aauuagcgug guuuccgagg agagguucua uacaaagugg     2040

aauccagagg cuuugcccuc gaacaccgga gaggucaacu uucaaucugg cauaauugcc     2100

gcucgcugcg ccauaucuaa guugcaucag gaacugggcg cgaagggguu uauacaaguc     2160

uacguugacc aaguggauga ggacaucguu gcugucacgc ggcacucacc uaguauucau     2220

caauccgugg uagcaguguc ucggacggcc uuuagaaacc caaagacauc auuuuacucg     2280

aaagaagugc cucaaaugug uauaccuggc aaaauugaag aggugguccu ggaagcccgc     2340

acgauagaga ggaauacuaa gccguauaga aaggaugaaa auucuaucaa cggcacuccg     2400

gauauuacag uagaaaucag agagcacauu caacuuaaug agucuaagau uguuaagcag     2460

gcugguguug caaccaaagg gccaaacgag uacauccagg agauugaauu ugaaaaucug     2520

ucaccgggcu ccgugaucau cuuuagagua ucuuuggauc cacaugcuca agucgcuguu     2580

ggaauccuga gaaaccaucu gacacaauuu uccccacauu uuaagagcgg cagccuggcc     2640

guggacaacg cagacccaau ccugaagauc ccauuugcau cccuggcuuc ccgccugacu     2700

cuggcugagc ugaaccagau cuuguaucgc ugugaaucug aagaaaaaga ggauggcgga     2760

ggcuguuaug acaucccaaa uuggagcgcc cugaaauaug ccggacucca aggccugaug     2820

uccguucugg ccgagauuag gccaaagaau gaucugggac acccauuuug uaacaacuug     2880

cggucuggag acuggaugau cgacuauguc agcaaccgcc ugauaagcag auccgguacu     2940

aucgcugaag ucggaaaaug gcugcaggcu auguuuuucu auuugaagca gauuccgaga     3000

uauuugaucc ccuguuauuu ugaugccauu cugauuggug cuuauacuac ccugcuggau     3060

accgcuugga aacagaugag uagcuuuguc caaaauggcu ccaccuucgu aaagcaucug     3120

ucgcugggcu ccgugcaauu guguggcguc gggaaguucc cuagccugcc aauccugucc     3180

ccugcucuga uggacgugcc uuaucgccug aacgagauua cgaaggaaaa ggaacagugu     3240

ugcgugucac ucgcugcugg gcugccacac uuuucuucug gaauuuuucg guguuggggg     3300

cgggacaccu uuauugcccu gaggggcauu cugcugauua ccggccgcua ugucgaggcu     3360

aggaacauua uccuggcuuu cgcggguacc cuucggcacg gacucauacc caaccuccug     3420

ggagaaggaa ucuaugcacg guauaacugu cgggacgcag uuugguggug guugcagugu     3480

auucaagauu auugcaagau ggucccgaac ggacuggaca uacugaagug cccagugucc     3540

cggauguauc caacugacga cuccgcacca cugcccgcug ggacacuuga ccagccauug     3600

uuugaaguua uucaggaagc uaugcagaag cauaugcagg gaauucaguu uagggagaga     3660

aacgcuggac cccagauuga ccguaacaug aaggaugagg gguuuaacau uaccgcggga     3720

guggacgaag agacuggcuu cgucuauggu ggcaaucggu ucaacugcgg caccuggaug     3780

gacaaaaugg gcgaaagcga uagagcucga aauaggggca ucccagcaac accacgggau     3840

ggcucugccg uggagauugu gggccugucu aagagcgcag uucggugguu guuggaacuc     3900

agcaagaaga acauuuuucc auaccaugaa guuacaguga agcggcaugg gaaggccauc     3960

aagguuucuu acgacgaaug gaaucggaag auccaggaua acuucgagaa acuguuucau     4020

guauccgagg acccuucuga ccugaacgaa aagcauccaa auuugguaca caaaagggga     4080

aucuauaagg auaguuaugg agccagcagc ccuuggugcg acuaucagcu acgaccaaac     4140

uucacuauug ccaugguagu agcaccagaa cucuuuacua ccgaaaaggc uuggaaggca     4200

cuggagaucg ccgagaagaa gcuguuaggu ccacugggca ugaaaacccu ggaccccgac     4260

gacaugguuu acuguggcau cuaugacaac gcucuggaca augacaacua uaaucuggcc     4320

aagggcuuca acuaccacca gggcccagag uggcuauggc caauuggcua uuuucugcgg     4380

gcgaagcugu acuuuucacg auugaugggc ccagagacaa ccgcuaagac cauaguauug     4440

gucaagaacg ugcugagucg gcacuauguc caccuggaaa ggagccccug gaaggggcug     4500

cccgagcuga ccaacgaaaa ugcacaguau uguccguuuu caugcgaaac ccaggcuugg     4560

uccaucgcga cgauccugga aacccucuau gaucuguag                            4599


<210>  9
<211>  4599
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Codon-Optimized AGL Coding Sequence

<400>  9
augggacacu caaaacagau aaggauccug cugcugaacg aaauggagaa acuggaaaag       60

acccuguucc ggcucgaaca gggauaugaa cuccaguuua ggcugggccc aacucugcaa      120

ggaaaagcug ugaccgucua uacuaacuau ccauuucccg gggaaacguu uaaccgagag      180

aaguuccgau ccuuggacug ggaaaauccc acagagcggg aggaugauuc ggacaaguau      240

ugcaagcuga aucugcaaca aucgggcagc uuucaguacu auuuucuaca aggaaacgaa      300

aagagcggcg ggggauacau ugugguggac ccaauccuga ggguuggggc agacaaucac      360

guacugccuu uggacugugu gacauugcaa acauuccugg caaagugccu gggccccuuc      420

gaugaauggg agucacggcu gcgaguggcu aaggaaucug gcuauaauau gauucacuuu      480

acaccauuac aaacgcuggg ccugagcaga aguugcuacu cgcuggcuaa ucaguuggag      540

uugaacccgg acuuuagccg ucccaaccgg aaguauacau ggaaugaugu uggccaacuc      600

guggagaagc ugaagaagga guggaacgug aucuguauua ccgaugucgu guauaaucau      660

acagccgcga acuccaagug gauucaggag cacccagaau gugcauauaa cuuggucaau      720

agcccccacc ugaagccggc cuggguacug gaucgggccc uguggcgguu uucuugugac      780

guggcagaag gaaaguauaa ggaaaagggg aucccagcac ugauagagaa cgaccaucau      840

augaacagca uuaggaagau cauuugggag gacauuuucc caaaguugaa gcucugggag      900

uuuuuccaag uugacgucaa caaggccgug gaacaauuuc gaaggcugcu gacacaggaa      960

aacagacgug uaacgaaguc cgaccccaau cagcauuuga cgaucauaca ggauccugag     1020

uauaggcgcu uuggcuguac ggucgacaug aauauugcuc ugaccaccuu uaucccucau     1080

gacaaggggc cagccgccau cgaagagugu uguaauuggu uccacaagcg cauggaagag     1140

uugaauuccg aaaagcauag guugaucaac uaccaccagg aacaggcagu gaacugucug     1200

cugggcaacg uguuuuauga gcggcuggcc ggucauggcc cuaagcuggg accagugacc     1260

aggaagcauc cacucguaac cagauauuuu accuucccgu uugaggagau agauuuuagc     1320

auggaagaau ccaugauuca ccuaccgaac aaggcuuguu uucugauggc ucacaacggu     1380

uggguuaugg gcgaugaucc ccugcgcaac uuugcggaac cgggcucuga gguguacuug     1440

agaagggagc ugauauguug gggggacucc gucaaacugc gcuaugggaa uaagccugaa     1500

gauugcccuu aucugugggc ccauaugaag aaguauaccg agauuaccgc gacauauuuu     1560

caaggagugc ggcuggacaa cugccacagc acgccgcugc auguggcaga guauaugcug     1620

gacgcagccc gcaaucugca gccaaaucug uauguugugg cugagcuguu uacgggcucc     1680

gaggaccucg acaacguuuu cguaacccgg cugggcauca gcagccugau ccgggaagcu     1740

augucagcgu auaauagcca ugaggagggc agacuggugu acagauaugg uggcgaacca     1800

guuggcagcu uugugcagcc cuguuugcgc ccucugaugc ccgccaucgc acaugcuuug     1860

uucauggaca ucacgcauga uaacgaaugu cccauuguac aucgcuccgc cuaugacgcu     1920

uugccaucca caacaaucgu guccauggcu uguugugcaa gcggcagcac caggggauau     1980

gacgaauugg uuccgcauca aaucagcgug guaucagagg aaagguuuua uacaaagugg     2040

aauccugaag cccugccauc caacaccggc gaagugaacu uucagucggg uaucauugcc     2100

gcgcguugcg cuauuagcaa acugcaucag gagcugggug cuaaaggcuu uauccaaguu     2160

uauguggauc aaguagacga agauauuguu gccguaacca gacauagccc cagcauucau     2220

caauccgugg uugcuguguc ccggacggcc uucaggaacc cuaaaacauc cuuuuauucc     2280

aaggaagucc cacagaugug uauuccggga aagauagagg aagugguuuu ggaggcucgc     2340

acgauugagc ggaacaccaa gccauauagg aaggacgaga acucgaucaa cggcacgccc     2400

gacauuaccg uugaaauucg cgagcacauu cagcugaacg aaucgaaaau ugucaagcag     2460

gccggcguag cgaccaaggg uccaaacgag uauauccagg aaaucgaguu ugagaaucug     2520

ucgccugggu ccguaaucau uuuuagaguc agccuagacc cucacgcuca aguggccgua     2580

gggauccuga ggaaucaucu gacgcaguuu ucaccccauu uuaaguccgg cagccuggca     2640

guggauaacg ccgaccccau ccugaaaauu cccuuugcuu cccuggccuc gcgccugaca     2700

cuggcagaau ugaaucagau acuguaucgu ugcgagagcg aggagaagga ggacggaggg     2760

ggguguuaug auaucccgaa cugguccgcu cugaaauaug cgggauugca gggcuugaug     2820

aguguacugg ccgaaauuag acccaagaac gaucugggcc auccguucug uaacaaucug     2880

cgauccggcg auuggaugau ugauuauguc agcaaccggu ugauaagccg gagugggaca     2940

auugcagaag ucggaaagug guugcaagcc auguucuuuu accugaagca gaucccucga     3000

uaucugauac cauguuauuu cgaugccauu cugaucgggg ccuauacaac ucuguuagac     3060

acugcuugga aacagauguc uagcuucgug caaaacggcu caacauuugu uaagcacuug     3120

agccuggggu cugugcaguu guguggcgua ggaaaguuuc ccucacugcc cauccugucg     3180

cccgcccuga uggacgugcc cuaccgccuc aacgaaauua ccaaggagaa agagcagugu     3240

uguguuagcu uggcugccgg uuugccgcau uuuucaagcg gaaucuuccg augcugggga     3300

cgcgauacgu ucauagcccu gagggguauu cugcugauua cgggcagaua cguagaggcu     3360

cggaauauua uccuggccuu cgccggcacg cugcggcaug ggcugauucc gaacuugcug     3420

ggagagggca ucuacgcccg guacaacugc agggacgcug ugugguggug gcugcagugc     3480

auccaggacu auugcaaaau ggugccaaac ggccuugaca uacugaagug uccugucucu     3540

cggauguauc caacggauga cuccgcaccc cugcccgcug gaacccugga ucaaccccug     3600

uuugaaguga uacaggaagc aaugcagaag cacaugcagg gaauucaguu uagagagaga     3660

aaugcaggcc cccaaaucga cagaaacaug aaagaugaag gcuuuaacau cacggcugga     3720

guggacgaag aaacuggguu uguguauggc gggaauaggu uuaacugugg gacguggaug     3780

gacaagaugg gcgaauccga uagagcgcgg aacaggggaa ucccggcuac accccgggac     3840

gguagugcug uggagauugu cggcuuaucc aaauccgccg ugcgcuggcu gcuggagcug     3900

uccaagaaga acaucuuucc uuaccaugaa gugaccguga agcggcaugg aaaggccauc     3960

aaagucuccu acgacgaaug gaauaggaag auucaggaca auuuugagaa gcuguuucau     4020

guguccgagg aucccagcga ccugaacgag aagcacccua auuuggugca uaagcggggc     4080

aucuauaagg acuccuacgg cgcuaguucg ccuuggugcg acuaucagcu gcggccaaac     4140

uuuacgauug cgaugguggu agcccccgaa uuguuuacga cggaaaaggc uuggaaggcc     4200

cuggagaucg cagaaaagaa gcugcugggg cccuugggca ugaaaacgcu ggaccccgac     4260

gauaugguuu auuguggcau cuacgacaac gcccucgaca augacaauua caaccuggca     4320

aaggguuuua acuaucauca ggguccugaa uggcuguggc caauuggcua cuuuuugcgg     4380

gccaagcugu acuuuucacg gcugauggga ccugaaacca ccgcuaagac cauuguacug     4440

gucaagaacg ugcugagcag gcauuacgug caucuggaaa gaagcccgug gaagggucug     4500

ccagaguuga cgaacgagaa cgcgcaguau uguccuuucu cuugugaaac gcaggcuugg     4560

aguauugcaa ccauucugga aacucuuuau gaccuguag                            4599


<210>  10
<211>  4599
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Codon-Optimized AGL Coding Sequence

<400>  10
augggccacu caaagcagau uagaaucuua cuccugaacg agauggaaaa gcuggaaaag       60

acccuguucc gccuggaaca gggauaugag cugcaguucc ggcuuggacc aacccuccaa      120

ggaaaggccg ugaccgugua cacgaacuac ccauucccgg gcgaaaccuu caacagagag      180

aaguuccgga gccuggacug ggaaaacccg accgaaaggg aagaugauag cgacaaguac      240

ugcaagcuga acuugcaaca guccggauca uuccaguacu acuuucugca agggaacgag      300

aagucgggcg gcgguuacau cgugguggac ccuauucugc gcgugggagc cgacaaccac      360

guguugccuc uggacugugu cacccugcaa acuuuccugg ccaagugccu ggggccauuc      420

gaugaguggg aaucgcggcu gcggguggca aaagaguccg guuacaacau gauccacuuc      480

accccacucc aaacccuggg ccuguccagg ucgugcuacu cgcuggccaa ccagcuggaa      540

cugaacccgg auuucucgcg gccuaacaga aaguauaccu ggaaugacgu cggacagcuc      600

gucgaaaagc ugaagaagga auggaacgua aucuguauca ccgaugucgu guauaaccac      660

accgcugcca acuccaagug gauccaggaa caccccgagu gcgcuuacaa cuuggugaac      720

ucgccccacc ugaaaccggc uugggugcug gaccgggccc uguggcgguu cagcugcgau      780

guggcugagg gaaaguauaa ggagaagggu aucccagcgc ucauugaaaa cgaccaccau      840

augaacucga uccgcaagau cauuugggag gauauuuucc caaaguugaa acugugggag      900

uuuuuccaag uggacgugaa caaggcgguc gaacaguuca gacggcuguu gacucaggaa      960

aaucggaggg ucaccaaguc ggaucccaac cagcaccuga ccauaaucca ggauccagaa     1020

uaccggcggu ucggcugcac uguggacaug aacauugccc ugaccacuuu uaucccacac     1080

gacaagggcc cggccgccau cgaagagugc ugcaacuggu uccacaagcg gauggaggaa     1140

cugaacucgg agaagcaccg ccugaucaac uaccaccagg agcaggcggu uaacugucug     1200

uugggaaacg uguucuacga gcgguuggcc ggccacggcc cuaagcuggg cccggucacc     1260

cggaagcacc cccuggucac ccgcuacuuc accuuuccau ucgaggagau cgacuucagc     1320

auggaagaau cgaugaucca ucugccgaac aaggccugcu uccugauggc ucacaacgga     1380

ugggugaugg gcgacgaucc ucugagaaac uuugccgagc cgggcucgga gguguaccug     1440

aggagggagc ugaucuguug gggggacagc gugaagcuga gauacggaaa caagccagag     1500

gacugcccgu accugugggc ccauaugaag aaguacaccg agauuaccgc aacauacuuc     1560

caaggggucc ggcuggacaa uugccacucg acuccccugc acguggcgga guacaugcug     1620

gacgcggcca ggaaccucca gcccaaccuc uacgucgugg ccgagcuguu cacugguucc     1680

gaggaccugg auaacguguu cgugaccaga cuggggaucu ccucacugau ucgcgaagcc     1740

auguccgcgu auaacucgca ugaagagggc cgccuggugu accgcuacgg aggcgaaccu     1800

gugggcagcu ucgugcaacc gugucugcgg ccucugaugc cugccauugc gcacgcccug     1860

uucauggaca ucacccacga caacgaaugc cccaucgugc accgguccgc cuacgaugcc     1920

cucccuucga cuacuaucgu guccauggcu ugcugcgcgu ccggcucgac ccgcggcuac     1980

gaugagcucg ugccgcauca gauuagcgug guguccgagg aaagguucua caccaagugg     2040

aauccagaag cgcugccgag caacaccggg gaggucaacu uccagucggg aaucaucgcc     2100

gcccgcugug ccaucuccaa gcugcaccag gaacugggcg cgaaggguuu cauccaaguc     2160

uacgucgauc aggucgacga ggacaucgug gccgugacuc ggcauucccc gagcauucac     2220

caguccgugg uggccguguc gcgcaccgcc uuccgcaacc cuaagaccag cuucuauuca     2280

aaagaagugc cgcagaugug caucccugga aagaucgagg aggugguccu ggaagcgcgg     2340

acuaucgaaa ggaacaccaa gccauaccgc aaggacgaga acuccaucaa cgguaccccg     2400

gacaucacug uggagauccg cgagcauauu caacugaacg aguccaagau cgugaaacag     2460

gccggagugg caaccaaggg accgaacgag uauauccagg aaauugaguu cgagaaccuc     2520

uccccgggaa gcgugauuau cuuccgcgug ucccuggacc cacacgccca aguggccguc     2580

ggcaucuugc ggaaccaccu gacucaguuc uccccgcauu ucaaguccgg aagccuggcg     2640

guggacaacg cggacccaau ccugaagaua cccuucgccu cacuggccuc gcgccugacu     2700

uuggccgagu ugaaucagau ccuguaccgc ugcgaauccg aagaaaagga ggacggugga     2760

ggcuguuacg acaucccuaa cugguccgca cugaaauacg caggacugca gggacugaug     2820

uccguccucg cugaaaucag accgaagaac gaucucggcc acccauucug caacaaccug     2880

agauccggcg auuggaugau ugauuacgug ucgaaccgac ugaucucccg cucggguacu     2940

auugcggaag ucggaaaaug gcugcaggcc auguucuucu accugaagca gaucccacga     3000

uaccuuaucc cuugcuacuu ugacgcgauu cugauuggug ccuacacgac ccugcuggac     3060

acggccugga agcaaauguc cagcuuugug cagaacggca gcaccuucgu gaaacaccug     3120

ucgcugggau cggugcagcu cugcggcgug gggaaguuuc cgucacugcc gauccugucc     3180

ccggccuuga uggaugugcc cuaccggcug aacgaaauca ccaaggagaa ggagcagugc     3240

ugcgugucgc uggccgccgg gcugccucac uucuccuccg gaauuuuucg augcuggggu     3300

agagacacuu ucauugcgcu gagggggauu cugcuuauua ccggccgcua cguggaagcc     3360

aggaacauca uccuggcauu cgccggaacc cugcggcacg ggcugauucc caaccuccuc     3420

ggagaaggaa ucuacgcucg guacaauugc cgggacgcag ugugguggug gcuccagugc     3480

auccaggacu acugcaagau ggucccuaac ggacuggaca uucugaagug cccagugucc     3540

cggauguacc ccacugacga uucggcaccg cugccggcug guacccugga ccagccgcug     3600

uucgaaguga uccaggaagc caugcaaaag cauaugcagg ggauucaguu ccgcgaaaga     3660

aaugccggac cucagaucga ccgcaacaug aaggaugaag gcuuuaacau cacugccgga     3720

guggacgaag agacuggauu cgucuacggg ggaaacagau ucaauugcgg uacauggaug     3780

gauaagaugg gagaaagcga cagagcucgg aauagaggaa uuccggccac accucgggac     3840

ggcucagccg uggagaucgu ggggcuaucc aagucugccg ugcgcuggcu guuggaacug     3900

ucgaagaaga acauuuuccc auaccacgag gucaccguga agcgccacgg aaaggccauc     3960

aaagugucau acgaugaaug gaaccgcaag auucaggaca acuucgagaa gcuguuccau     4020

gugucggagg acccuuccga ccugaacgaa aagcauccaa accuggugca caagcggggg     4080

aucuacaagg acuccuacgg agcguccucc ccuuggugcg acuaccaacu ccggccaaau     4140

uucacgaucg cgaugguggu ggccccugaa uuguuuacca ccgaaaaggc cuggaaggcc     4200

cucgagaucg cagagaagaa acugcuggga ccccugggca ugaaaacccu ggacccggac     4260

gauauggugu acugcggaau cuacgacaac gcccucgaua augacaacua uaacuuggcc     4320

aaggguuuca auuaccacca ggggccagag uggcuguggc caaucgguua cuuucugcgg     4380

gccaagcugu acuucucgag auugaugggg cccgaaacca ccgcuaagac uaucgugcuc     4440

gucaagaacg ugcugucacg gcauuacgug caccuggaac gcagcccaug gaagggccug     4500

ccggaacuga ccaacgagaa cgcacaguac uguccguucu cgugugaaac ucaggccugg     4560

agcauugcga ccauccugga aacucucuau gaucuguag                            4599


<210>  11
<211>  4599
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Codon-Optimized AGL Coding Sequence

<400>  11
augggccauu cuaagcaaau ucggauacug cugcugaacg aaauggagaa acuugaaaag       60

acccuguucc ggcuggagca gggcuaugag cugcaguuua gauugggccc gacacugcag      120

gggaaggcag ucaccguuua uaccaauuau ccuuuuccug gggaaacguu caaucgugaa      180

aaguuucgga gccucgacug ggaaaacccu accgagcgag aggaugauag cgacaaguau      240

uguaaacuca aucugcagca gucaggcuca uuccaauauu auuuucugca agggaacgag      300

aagucuggcg gaggcuacau ugucguugau ccgauacugc ggguuggcgc cgacaaccac      360

guguugccuc uggacugcgu gacacugcaa acauuucucg cgaaaugcuu aggccccuuu      420

gaugaguggg aaagccgccu gagagucgcc aaggagagcg gcuauaauau gauccauuuu      480

acgccgcugc aaacacuggg ucugucuagg ucauguuacu cauuggcuaa ccagcuggag      540

cugaacccgg acuuuaguag gccuaacagg aaguauacau ggaaugaugu ugggcaacug      600

guggagaagc ugaagaagga auggaauguc auuuguauua ccgaugucgu guacaaccac      660

acggcagcaa auucaaagug gauucaggaa cauccggaau gcgcuuauaa ccucguaaac      720

ucaccgcacc ugaagccggc cuggguacug gacagggcac uguggagauu cucuugugau      780

guagccgagg ggaaguacaa ggagaaaggc auucccgcuc uuauugaaaa ugaccaccau      840

augaauagca uuaggaagau caucugggaa gauauuuuuc caaaacugaa gcugugggaa      900

uucuuucaag uugacgugaa caaggcuguc gagcaguuca ggcggcuguu gacccaggag      960

aacagacggg uuacuaagag ugaccccaac caacaucuga cgaucaucca ggacccagag     1020

uaucggcgcu uuggcugcac aguggacaug aacaucgccc ugaccacguu uaucccccau     1080

gauaagggcc cggccgcuau ugaagagugu uguaacuggu uucauaagcg cauggaagaa     1140

cucaacagcg aaaagcauag acugaucaac uaucaucaag aacaggcugu gaauugucug     1200

cugggcaacg uguuuuauga gcgguuggcu ggccauggcc ccaaguuggg ccccgugacg     1260

cgaaaacauc cccucgugac aagauauuuc accuuuccau uugaagagau cgacuucuca     1320

auggaggaaa gcaugauuca ucugccaaac aaggcuuguu uucugauggc ucauaauggc     1380

uggguuaugg gcgacgaccc ccugagaaac uuugcggaac cagggucuga aguguaucug     1440

cggagggaau ugauuugcug gggagacucu guaaagcugc gauaugggaa caagccggag     1500

gauuguccgu aucugugggc ccauaugaag aaguauacag aaauuaccgc aacguauuuu     1560

cagggcguac gccuggauaa uugucauuca acgccacugc auguggcaga guacaugcua     1620

gacgcggcua ggaaucugca gccgaaucug uaugucgugg ccgagcuguu caccggcucc     1680

gaagauuugg acaauguguu ugugacccgc cucgguauua gcucacugau uagagaagca     1740

augucggcuu acaauucgca ugaggaaggu cgccuggugu accguuacgg cggcgaaccc     1800

gugggcaguu uugugcaacc cugucugagg ccacuaaugc ccgcuauugc acaugcccug     1860

uuuauggaua uaacacauga uaacgaaugu ccaaucguac accggagugc uuaugaugcu     1920

cugcccucaa cgaccaucgu aucaauggca ugcugugccu ccggcucaac acggggcuau     1980

gaugaacugg uaccacacca gaucagcgug guuucugagg aacgguuuua cacaaagugg     2040

aauccugagg cguugccauc caacacuggc gaagugaacu uucagagcgg cauuauugcu     2100

gcccgaugug cuauuucaaa gcuacaccag gaguugggcg caaagggguu uauccagguu     2160

uauguggacc agguugacga agauaucgua gcugugacgc ggcacucucc gucuauccau     2220

caauccgugg uagccguguc uaggacggcu uuucgcaacc ccaagacaag uuucuauucc     2280

aaagaaguac cccagaugug uaucccgggg aagauugagg aagugguccu ggaggccagg     2340

acgauagaac ggaacacgaa gccguaucgc aaggacgaaa acagcauaaa cgggacgccu     2400

gacaucacgg uggagauucg cgagcacauc caguugaacg aaucaaagau agugaaacag     2460

gcuggggugg cuaccaaggg cccaaaugag uacauucagg agaucgaguu cgaaaaccug     2520

uccccgggca gugugaucau cuuuagaguc ucuuuggauc cgcaugccca ggucgcugug     2580

ggcaucuugc gaaaucaccu gacgcaguuu ucuccacauu uuaagagugg cucccuggcu     2640

guggacaacg ccgacccaau cuugaagauu ccguucgcuu cccuggcuuc acgucugacu     2700

cucgcugaau ugaaucaaau ucuguauaga ugcgaaucag aggagaagga agauggaggc     2760

gguuguuacg acaucccgaa uuggucggca cugaaauacg ccggucugca aggcuugaug     2820

agcguacugg ccgagauaag accaaagaac gaucugggcc acccauuuug caacaacuug     2880

cgguccggcg auuggaugau ugacuauguc ucuaaccgac ucaucaguag aagcggaacc     2940

auagcugagg ucggcaaaug gcugcaagcc auguucuucu auuugaagca gaucccccga     3000

uaucugaucc ccuguuauuu ugacgcaauc cucauuggcg ccuauaccac acuccucgac     3060

accgcuugga agcagauguc cucauuugug caaaacggua gcaccuuugu gaagcaucug     3120

ucgcugggua gugugcagcu cugcggcgua gggaaguucc ccaguuugcc gauccugagu     3180

ccagcucuaa uggacgugcc auauaggcug aacgagauua ccaaggaaaa ggagcagugu     3240

ugugucuccc uugcugccgg ucugccccau uuuuccucgg gcauuuuuag auguuggggg     3300

cgggacaccu ucaucgcucu gcggggcauc cugcugauca ccggcagaua uguggaggcu     3360

cggaauauua uucuggcuuu ugcugggacg cugcgccaug gacugauucc caaucuauug     3420

ggcgaaggca uauacgcuag guauaacugu cgggacgcug uuugguggug gcugcagugu     3480

auccaagauu auugcaagau gguccccaac ggccuggaca uacugaaaug uccaguaucu     3540

aggauguacc cgacugacga cagugcuccc cugcccgcug gaacuuugga ucaaccccug     3600

uuugagguua uucaagaggc uaugcagaag cacaugcagg gcauucaguu ucgcgaaagg     3660

aacgccggcc cccaaauuga ccguaacaug aaggacgaag gcuucaauau uacggcuggc     3720

guagaugaag aaacaggcuu uguguacggc ggcaaccgcu ucaacugugg gacauggaug     3780

gacaagaugg gcgaaagcga cagggcucgg aacaggggaa uuccagccac gccccgcgau     3840

ggcagugcug uugaaauugu cggcuuguca aaaucagccg uacgcugguu auuagagcuc     3900

uccaagaaga acaucuuucc guaucaugaa gucacgguua agcggcaugg aaaagcaauc     3960

aaagugucuu acgacgaaug gaauaggaaa auucaggaca acuuugagaa gcuguuccau     4020

gugucugagg acccguccga ucuuaacgag aagcauccca auuuggugca caagaggggc     4080

aucuauaagg acucauacgg ggcuagcuca ccuuggugug acuaucagcu gcgaccgaau     4140

uucacaauag cuauggucgu ggcuccggag cuuuuuacca ccgagaaggc uuggaaggcc     4200

cuggagauug ccgagaagaa gcuguuaggc ccguugggca ugaaaacguu ggauccagac     4260

gacauggucu auuguggcau cuaugacaac gcucucgaca augacaacua uaaccuagcu     4320

aagggcuuca auuaccauca gggcccggag uggcuguggc caauuggaua uuuccugagg     4380

gcaaagcugu auuucucccg gcugaugggc cccgagacaa cggcaaaaac cauagucuug     4440

guuaagaacg ugcugucccg ccacuaugug caccuugaaa ggaguccgug gaagggccug     4500

ccggagcuga caaacgaaaa ugcccaguac ugcccauuuu cuugcgaaac ucaggcuugg     4560

agcaucgcca caaucuugga aacccuguau gacuuguag                            4599


<210>  12
<211>  4599
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Codon-Optimized AGL Coding Sequence

<400>  12
augggacacu cgaagcagau ccgcauccuc cugcugaacg aaauggaaaa acuggaaaag       60

acacucuucc ggcuggaaca gggauaugag cugcaguuua gacuggggcc caccuuacaa      120

ggaaaggccg ugacugucua uaccaacuac ccguuccccg gagaaacuuu caaccgggaa      180

aaguuccggu cacuggacug ggaaaacccg accgagcggg aggacgauag cgacaaguac      240

ugcaagcuga accuucagca guccggaucg uuccaguacu acuuccugca agggaacgag      300

aagucgggcg gaggauacau uguggucgau ccuauccugc gcgugggagc ugacaaucac      360

gugcucccuc uggacugcgu gacgcugcaa accuuccucg caaagugccu cggaccuuuc      420

gacgaauggg aauccagacu ccgcguggcc aaggagucag gauacaacau gauccacuuc      480

acgccgcugc agaccuuggg acucucucgg agcuguuacu cccuggccaa ccagcuggaa      540

cugaacccag acuucucacg cccgaauaga aaguacaccu ggaacgacgu gggacagcuu      600

guggagaagc ucaagaagga auggaacguc aucugcauaa ccgacgucgu guacaaccac      660

accgcagcca auucuaagug gauucaggaa caccccgaau gcgccuacaa ucugguuaac      720

ucaccccacc uuaagcccgc cuggguccua gacagagccc ucuggcgguu cucgugugac      780

guggccgagg gaaaguacaa ggagaaggga auccccgcuc ugauugaaaa cgaccaccac      840

augaacucca uccgcaagau uaucugggag gacaucuucc cgaagcucaa gcugugggaa      900

uucuuccaag uggacgugaa caaggcgguc gagcaguuca gacgccugcu gacccaggaa      960

aaucggagag ugaccaagag cgauccuaac cagcaccuga ccaucaucca agacccagag     1020

uaccggcggu ucggaugcac uguggauaug aacaucgccc ugaccacuuu caucccucac     1080

gacaagggac cggccgcaau ugaggaaugc ugcaacuggu uccauaagcg gauggaggaa     1140

cugaacagcg agaagcaucg acugaucaau uaucaucaag agcaggcugu gaauugccug     1200

cugggaaacg uguucuacga acggcuggcc ggacauggcc cuaagcuggg gccugugacc     1260

cggaagcacc cucuugugac ccgauacuuc accuucccgu uugaagaaau ugauuucucc     1320

auggaagaau ccaugaucca ucugccaaac aaggccugcu uccuuauggc ccacaauggc     1380

ugggucaugg gggacgaccc ucuucggaac uucgccgaac cagggagcga gguguaccuc     1440

agaagggagc ucaucuguug gggggauucc gugaagcuca gauacggaaa caagccagaa     1500

gauugccccu accuuugggc ccacaugaag aaguacaccg aaaucaccgc cacauacuuc     1560

caaggagugc ggcuggacaa cugccauuca acuccccugc acgucgccga guacaugcug     1620

gacgcugcga gaaacuugca gcccaaccuu uacguggugg ccgagcuguu caccgggagc     1680

gaggaccugg acaacguguu ugugaccagg cucggaaucu cgucgcugau ucgcgaagcc     1740

augagcgccu acaacuccca cgaagagggu agacuggugu acagauacgg aggagagcca     1800

gugggauccu ucguccaacc gugccugcgg ccgcucaugc cugcgaucgc acacgcgcug     1860

uucauggaca ucacccacga uaacgaaugu ccuaucgugc auaggagcgc cuaugaugcc     1920

cuucccucca ccaccaucgu guccauggcg ugcugugccu cggguagcac caggggauac     1980

gacgagcugg ugccgcacca gaucucggug guguccgaag aacgguuuua cacuaagugg     2040

aacccugagg cgcugccuuc caacaccgga gaagugaacu uccaguccgg uaucauugcc     2100

gcucgcugcg caaucagcaa acugcaccag gagcuuggug ccaaaggauu cauccaaguu     2160

uacgucgauc aaguggacga ggauauugug gccgucacua ggcacucucc aagcauucac     2220

caguccguag uggcaguguc gaggaccgcc uuccggaacc ccaagacuuc auuuuacucg     2280

aaagaggucc cacagaugug caucccugga aagaucgaag aaguggugcu ggaagcccgg     2340

accaucgaga ggaacacaaa gcccuaccgg aaggacgaga acuccaucaa cggaaccccc     2400

gacauuaccg uggaaauuag agagcacauc caguugaacg agucgaagau cgugaagcag     2460

gccggagugg ccacuaaggg accaaacgag uacauccagg agaucgaguu ugaaaaccug     2520

uccccgggcu ccgugaucau cuuccgggug ucccuugacc cccaugccca aguggccguc     2580

ggaauccuua ggaaccaccu gacccaguuu ucgccccauu ucaaguccgg auccuuggcu     2640

gucgacaaug ccgaucccau ccugaaaauu ccguucgccu cccucgcuuc ccggcucacc     2700

cuugccgaac ucaaccagau ucuguaccgc ugcgagucag aagaaaagga agauggaggg     2760

ggaugcuacg acaucccgaa cugguccgcc cuuaaauacg ccgggcugca aggccugaug     2820

uccgugcugg cggagauuag accgaagaac gacuuggguc acccuuuuug caacaacuug     2880

cggagcggag acuggaugau cgacuacgug ucgaaccggc ugauuagucg guccggaacc     2940

aucgccgaag ucggaaagug gcuccaagcc auguucuucu accugaagca aauuccccgc     3000

uaccugauac cgugcuacuu cgacgccauc cucauuggag ccuacaccac gcugcuggac     3060

accgccugga agcaaaugag cuccuucgug caaaacggau caaccuucgu gaagcaccug     3120

ucccugggua gcguccagcu cuguggcgug ggaaaguuuc cgucccugcc aauucugagc     3180

ccggcucuga uggaugugcc guaucgccug aacgagauca cgaaggagaa ggagcagugu     3240

ugcgugucgc uggcugcggg acugccucac uucucguccg gaaucuuccg cuguugggga     3300

cgcgacacgu uuaucgcguu gagggguauu cuccucauua ccggacgcua cguggaagcg     3360

cggaacauua uccuggcguu cgccggaacc cugcgccacg gucugauucc uaaucugcug     3420

ggagagggaa ucuacgcgcg guacaacugc cgggaugcug ugugguggug guugcagugc     3480

auccaggacu auuguaaaau ggugccgaac ggccuggaca uccugaagug cccggugucc     3540

cggauguacc cgaccgauga uucagcacca cugcccgccg ggacccugga ccagccccug     3600

uucgaaguca uucaggaagc gaugcagaag cauaugcagg gaauccaguu ccgcgaaaga     3660

aacgccggac cucagaucga ccgcaacaug aaggaugagg gcuucaacau caccgcggga     3720

guggaugagg aaaccggcuu cgucuacgga gggaaccggu ucaacugcgg aaccuggaug     3780

gacaagaugg gagaguccga ccgcgcaaga aaccgcggua uuccugccac cccgcgggac     3840

ggaagcgcgg uggagaucgu cggacugagc aagagcgcag ugcgcuggcu gcuggaguug     3900

uccaagaaga auaucuuccc cuaucacgag gucaccguga aacgccacgg gaaggccauc     3960

aaaguguccu acgaugagug gaaccgcaag auucaggaua acuucgaaaa gcuguuucau     4020

guguccgagg aucccuccga ccucaacgaa aagcacccga accucgugca uaagaggggg     4080

aucuacaagg acagcuacgg ugccuccuca ccuuggugcg auuaucagcu ccgcccgaac     4140

uucaccauug ccaugguggu cgccccugaa cuguuuacua ccgagaaggc cuggaaggcg     4200

cuggagauug ccgaaaagaa gcuguuggga ccccugggca ugaaaacccu cgaccccgac     4260

gacauggugu acugcggaau cuacgacaac gcccucgaca acgacaacua caaccucgcg     4320

aagggguuca acuaccacca gggccccgaa uggcuguggc ccaucggaua cuuccuccgg     4380

gcgaaguugu acuucucccg ccugaugggc ccugaaacca cggccaaaac gaucgugcuc     4440

gugaagaacg ugcugucgag gcauuacgug caccucgagc ggagcccgug gaaggggcug     4500

ccggaacuga ccaacgagaa ugcacaguac ugccccuucu ccugcgaaac gcaggcuugg     4560

uccauugcca cuauuuugga aacgcuguac gaccuguag                            4599


<210>  13
<211>  4599
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Codon-Optimized AGL Coding Sequence

<400>  13
augggacacu cgaaacagau cagaauccug uugcucaacg aaauggagaa gcuggaaaag       60

acccucuuuc ggcucgagca gggcuacgag cugcaguucc gccugggucc gacacuacaa      120

ggaaaggcag ugacugugua caccaacuac ccauuucccg gagaaaccuu caaccgggag      180

aaguuccggu cccuggacug ggaaaaccca accgaacgag aggaugacuc cgacaaguac      240

ugcaagcuga accuccaaca guccgguuca uuccaguacu acuuucugca agggaacgag      300

aaguccggag gcggcuacau cguggucgac ccgauacuua gagugggagc cgacaaucau      360

guccugccuc uggacugcgu gacccugcaa accuucuugg ccaaaugucu gggcccguuc      420

gaugaguggg aaagccgccu cagagucgca aaggaguccg gauacaacau gauucacuuc      480

acuccgcugc aaacccucgg ucugucccgg ucgugcuauu cucuggcgaa ccagcuggag      540

cuuaaccccg acuucucgcg cccaaaccgg aaguacaccu ggaacgacgu cgggcagcuu      600

guggaaaagc ugaagaagga guggaacgug aucugcauca cugacguggu guacaaccau      660

acggccgcca acucgaagug gauccaagag caucccgagu gcgcguacaa ccucgugaac      720

agcccgcauc ugaagccugc uugggugcug gauagagccc ucuggagauu cagcugcgac      780

guggccgagg ggaaguacaa agaaaaggga auuccggccu ugauugagaa cgaccaucac      840

augaacucaa uccgcaagau caucugggag gauaucuucc cuaagcuuaa guugugggag      900

uucuuccaag uggacguaaa caaggcagug gagcaguuca gaagguugcu gacucaagaa      960

aacagacgcg ucacuaaguc cgauccuaac cagcaccuua ccaucauuca agacccugag     1020

uaccgccggu uuggcugcac cgucgacaug aacaucgccc ugaccacuuu caucccgcau     1080

gacaagggcc cggcggcaau cgaggaaugc uguaacuggu uucauaagag gauggaggaa     1140

cugaauuccg agaagcaccg gcugauuaac uaccaccagg aacaggcagu gaauugccuc     1200

cugggcaacg uguucuacga acggcuggcu ggacacggac cgaagcuggg ucccgugacu     1260

cgcaagcauc cgcucgugac ucgcuacuuc accuucccgu uugaggagau ugacuucucc     1320

auggaagaau ccaugaucca ccucccgaac aaggcuugcu uccugauggc gcacaacgga     1380

ugggucaugg gcgacgaccc acugcgcaac uucgcugagc cuggcucgga ggucuaccug     1440

agaagggaau ugauuugcug gggagacucc gucaagcugc gcuauggaaa caagcccgaa     1500

gauugccccu accugugggc ucacaugaag aaguacacgg aaaucacugc cacguacuuc     1560

cagggagucc ggcuggacaa uugccacucc accccccucc auguggccga guacaugcuc     1620

gaugcagcga ggaaucugca gcccaaucug uacgugguug cagaacuguu cacuggcucc     1680

gaggaccucg acaacguguu cgugaccaga cuggggaucu ccucccugau ccgggaagcc     1740

augucggccu acaacuccca ugaagagggc cgccuggugu accgcuacgg cggagaaccc     1800

gugggaagcu ucgugcagcc uugccuccgg ccgcugaugc cugcgaucgc ccacgcccug     1860

uucauggaua ucacucacga caacgaaugc cccauugugc aucgcucggc cuacgacgca     1920

cugccuucga ccacuaucgu guccauggcc ugcugcgccu ccgggagcac ccgcggauac     1980

gaugaacucg ugccgcacca gaucagcgug guguccgaag aaagauucua uaccaagugg     2040

aaccccgaag cccugccgag caauaccggg gaagugaacu uccaguccgg uauuaucgcc     2100

gcucgcugug ccaucagcaa acuccaccaa gagcucggug ccaagggauu cauucaaguc     2160

uacguggauc aggucgacga agauauugug gccgugacca ggcacucacc uuccauccac     2220

caauccgucg ucgccguguc ccggacugcg uuucggaacc ccaagacuuc guucuacucg     2280

aaagaagugc cacagaugug uaucccggga aaaaucgaag aggucgugcu cgaagcccgg     2340

accauugaga ggaacaccaa gccuuaccgg aaagacgaga acucuaucaa cgguaccccu     2400

gauauuacug uggagauccg cgaacacauc cagcugaacg aaucaaagau cgucaagcag     2460

gcuggagugg ccaccaaggg acccaacgag uacauccagg agaucgaauu ugaaaaccuc     2520

uccccuggcu ccgugauuau cuuccgggug ucccuggacc cucacgccca aguggccgug     2580

ggaauucuca gaaaccaccu gacccaguuc ucaccccacu uuaaguccgg uucccuggcg     2640

guggacaacg ccgauccgau cuugaagauc cccuucgcau cgcuggccuc ccgccugacu     2700

cucgcggaac ugaaccagau ccuguaccgc ugugaaucag aggaaaagga ggacggcggc     2760

ggcuguuacg auauccccaa uuggucggcu uugaaauacg cgggacuuca ggggcugaug     2820

ucugugcugg cggaaauccg gccgaagaac gaccugggac acccauucug caacaacuug     2880

cggagcggag acuggaugau cgauuacguc agcaacagau ugaucagccg gagcggcacu     2940

aucgccgagg ucggaaagug gcuccaggcc auguucuucu accugaagca gaucccccga     3000

uaccucaucc ccuguuacuu cgacgccauu cugaucgggg ccuacaccac ccugcuggac     3060

accgccugga agcagaugag caguuuugug caaaacgggu ccaccuucgu gaagcaccuu     3120

ucacugggcu cagugcagcu cugcggcgug ggaaaguucc ccucgcugcc cauucugagc     3180

ccggcccuga uggacguccc uuaccggcug aacgagauca ccaaggagaa ggagcagugc     3240

uguguuuccc uggcugccgg gcugccacac uucucguccg gcaucuuccg gugcuggggc     3300

cgggauaccu ucauugcccu gcggggaauc cugcuuauca ccggucgcua cguggaggcu     3360

cggaacauua uucuggcguu cgccggcacc cuuagacacg gucugauucc gaaucuuuug     3420

ggcgaaggaa ucuacgccag auacaacugu cgggacgccg ugugguggug gcuccagugc     3480

auucaggacu auugcaagau ggugccgaac ggccuggaca uccugaagug cccagugucg     3540

aggauguauc caaccgacga cagcgcaccu cugccggccg ggacccucga ccaaccccug     3600

uucgaaguca uucaagaggc uaugcagaag cacaugcagg guauucaguu ccgggagcgg     3660

aacgcggggc cccagauuga uaggaacaug aaagacgagg gcuucaacau cacugccggc     3720

guggacgaag aaaccgguuu uguguacgga ggaaacagau ucaacugcgg uaccuggaug     3780

gacaagaugg gagaguccga ucgcgcgcgc aacagaggga ucccggcaac cccgcgggac     3840

ggauccgcgg uggaaauugu gggacugagc aagagcgccg ugcgguggcu ccuggaacug     3900

agcaaaaaga acaucuuccc cuaccacgaa gugaccguga agcggcacgg aaaggccauc     3960

aaagucucau acgaugaaug gaauaggaag auccaggaua acuucgagaa gcuguuucac     4020

guguccgagg aucccuccga ucugaacgaa aagcauccga aucucgugca caagcgcggg     4080

aucuacaagg acucguacgg agcguccucc ccuuggugcg acuaucagcu gcggccuaac     4140

uucaccauug ccauggucgu ggccccggag cuguucacaa cugagaaggc cuggaaggcc     4200

cuugaaauug ccgagaagaa gcugcugggg ccuuugggga ugaaaacccu ggauccggac     4260

gacauggugu acugcggaau cuacgacaac gcccuggaca acgauaacua caaucuggcg     4320

aagggcuuca auuaccacca gggcccggaa uggcucuggc cuauugggua cuuccugcgc     4380

gccaagcugu acuucucacg gcugauggga ccagagacua ccgccaagac uaucguccuc     4440

gugaagaacg ugcugucccg gcacuacgug caucuggaga ggagcccuug gaagggacuu     4500

ccugagcuga cgaacgaaaa cgcgcaguac ugccccuucu ccugcgaaac ccaggcuugg     4560

uccauugcca cuauacugga aaccuuauau gaccuguag                            4599


<210>  14
<211>  4599
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Codon-Optimized AGL Coding Sequence

<400>  14
augggucacu ccaagcaaau cagaaucuua cuccuuaacg aaauggaaaa gcuugaaaag       60

acacucuucc gcuuggagca gggcuacgag cugcaguucc ggcugggucc gacacuucag      120

gggaaagccg ugaccgugua uaccaacuac cccuuuccgg gagaaacauu caaucgcgag      180

aaguuccggu cgcuggacug ggagaacccu accgagaggg aggacgacuc ugauaaguac      240

ugcaagcuga aucuccagca aucagguucu uuccaauauu acuuccuuca aggaaacgaa      300

aaguccgggg gcggcuacau uguaguggac cccauccuuc gggucggcgc ggauaaccau      360

gugcuucccc ucgacugcgu gacucuccaa acuuuccucg ccaagugccu gggaccauuc      420

gaugaauggg aaucccgccu gcgcguggcc aaggagagcg gcuacaacau gauucacuuc      480

acuccgcuuc aaacccuugg gcugucccgc uccugcuauu cccuugcgaa ccagcuggaa      540

cuuaacccgg acuucucucg gccgaacaga aaguacacuu ggaacgacgu gggccagcuu      600

gucgagaagc ugaagaagga auggaacgug aucugcauca ccgacguggu guacaaccac      660

accgcggcaa acuccaagug gauccaggaa cauccugagu gcgcauacaa ccucgugaac      720

aguccgcauc ugaagccugc cugggugcug gauagagccc uguggcgcuu cuccugcgac      780

guggcugagg gaaaguacaa ggaaaagggc aucccugcgc ucauugaaaa cgaucaccac      840

augaacagca uccgcaagau uauuugggag gacaucuucc cuaagcucaa gcucugggag      900

uuuuuccaag uugacgugaa caaggccgug gagcaguuca gacggcuccu gacucaagaa      960

aacagacgcg ucaccaaguc cgacccuaac caacaccuca ccaucaucca ggaucccgaa     1020

uaccgccggu uuggcugcac uguggacaug aacauugccc ugaccaccuu cauuccgcac     1080

gacaaaggcc cggccgcgau ugaagagugc uguaacuggu uccacaagag aauggaggag     1140

cugaacuccg aaaagcauag acuuaucaac uaccaccagg aacaggccgu gaacugccug     1200

cugggaaacg uguuuuacga gagacucgcc ggacacgguc caaaguuggg uccugugacc     1260

cgcaaacacc cgcucgucac ccgcuacuuu accuucccgu ucgaggagau cgacuucagu     1320

auggaggaga gcaugaucca ucuccccaac aaggccuguu uccucauggc ccacaacggc     1380

ugggucaugg gcgacgaccc ccugcgcaac uucgcugaac ccggcucgga aguguaccuu     1440

cggagggagc uuaucuguug gggcgacagc gugaagcuua gauacggcaa caagccagaa     1500

gauuguccgu accugugggc gcacaugaag aaguacaccg agaucaccgc gacguacuuu     1560

caaggagugc ggcucgauaa cugccacucc accccucugc acguggcaga guacaugcua     1620

gacgcggccc ggaaccucca gcccaaccuu uacguggugg ccgaacucuu cacugguucu     1680

gaggaucuug auaacguguu cgugacuagg cucggcauuu ccucccucau ccgggaagcc     1740

augucggccu auaacuccca cgaggagggg cggcuggugu accgcuacgg aggcgaaccg     1800

gucggcagcu ucgugcagcc gugccuccgc ccucugaugc ccgcuauugc ucacgcccuu     1860

uucauggaua ucacucacga uaaugagugc ccuaucgugc aucggagcgc cuacgacgcu     1920

cucccuucca ccaccaucgu guccauggcg ugcugcgccu ccgguucaac caggggcuac     1980

gaugaacuug ugccgcacca gaucucaguc gucagcgagg aaagguucua cacuaagugg     2040

aacccugaag cccugcccuc uaacacgggc gaagugaacu uucagagcgg uaucauugcc     2100

gcuagaugcg caaucuccaa guugcaccag gaacugggag ccaagggguu cauccagguc     2160

uacguggacc aggucgacga ggacaucguc gccgugaccc ggcauucccc gagcauccau     2220

caguccgugg ucgccguguc acggaccgcc uuccgcaacc ccaagaccuc cuucuacucc     2280

aaggaagugc cgcaaaugug uaucccuggc aaaaucgagg aaguggugcu cgaagcgcgg     2340

acgauugaga ggaauacuaa gccguacaga aaggacgaaa acuccaucaa cggcaccccg     2400

gacaucacug uggagauccg ggagcacauc cagcucaacg agagcaaaau ugugaagcag     2460

gccggcgucg cuacuaaggg cccaaacgag uacauccagg agauugaguu cgaaaaccuu     2520

agcccugggu cugugaucau cuuucgcgug ucccucgacc cgcacgcaca ggucgcaguc     2580

gggauucucc ggaaccaucu gacucaguuc agcccccacu ucaagagcgg cagccuugcc     2640

gucgacaacg ccgaucccau ccucaaaauc ccuuucgcau cccuugcguc gaggcuuacc     2700

cuggcggaau ugaaccagau ucuguaccgc ugcgagucgg aagaaaaaga ggauggcggc     2760

ggcugcuacg acauuccgaa cugguccgcc cugaaauacg cgggccuuca gggccuuaug     2820

agcgucuugg ccgagauccg ccccaagaac gaccuggggc accccuuuug caacaaccuc     2880

agaagcggcg auuggaugau cgacuacgug ucgaacaggc ucaucagccg auccggcacu     2940

auagccgagg ucggaaagug gcugcaggcc auguucuuuu accucaaaca gaucccgcgg     3000

uaccugaucc cgugcuacuu cgacgcuauu cucauuggcg ccuacacuac ccugcucgau     3060

accgcuugga agcagaugag cucauucgug caaaacggaa gcaccuucgu gaagcaccuc     3120

ucccugggau cagugcagcu gugcggcgug ggaaaguucc cauccuuacc aauucucucg     3180

ccugcccuga uggacguccc uuaucgccug aacgaaauca cgaaggagaa ggaacagugu     3240

ugugucucac uggcugccgg ccucccgcac uucucauccg gcaucuuccg gugcuggggu     3300

agagacacuu ucauugcgcu ccggggaauu cugcuuauca cuggccgcua cguggaagcc     3360

cgcaacauca uccuugccuu ugccgggacc cugcggcacg gccugauccc uaaccuucuc     3420

ggggagggca ucuaugcgcg auacaauugc cgggacgccg ucugguggug gcugcagugc     3480

auucaggacu auugcaagau ggugccaaau ggucuggaca uucugaagug uccagugucc     3540

cggauguacc cuaccgacga uagcgcccca cugcccgccg gaacccucga ucagccccug     3600

uucgaaguca uucaggaagc gaugcagaag cauaugcagg guauccaauu ccgcgaaagg     3660

aaugccggcc cacaaaucga cagaaauaug aaggaugagg gcuuuaacau caccgccggc     3720

guggacgagg agacugguuu cgucuacggc ggcaaucggu ucaauugcgg gaccuggaug     3780

gacaagaugg gcgaaagcga ccgggccaga aaccggggca uuccggcuac cccccgcgau     3840

ggcucggccg uggaaaucgu gggccucucc aagucugccg ugcgguggcu uuuggagcuc     3900

uccaagaaaa acaucuuccc guaccacgaa gugaccguga agagacacgg gaaggccauc     3960

aaaguguccu acgacgaaug gaaccggaag auccaggaca acuucgaaaa gcuguuccac     4020

guguccgagg aucccuccga cuugaacgaa aagcacccca accucgugca caagcgcggc     4080

aucuacaagg auuccuacgg agcguccuca ccuuggugcg acuaucagcu gaggcccaac     4140

uucaccaucg caaugguggu ggccccugag uuguucacca cugagaaggc uuggaaggcc     4200

cuugagaucg ccgaaaagaa gcugcucggc ccgcugggga ugaaaacccu cgaccccgau     4260

gacauggugu acugcgggau auacgacaau gcacuagaca acgacaacua caaccuggcc     4320

aagggcuuca auuaccauca gggcccggag uggcuuuggc cuaucggcua cuuccugcgg     4380

gccaagcugu acuucucacg gcuuauggga ccggagacua cugcaaagac cauugugcuu     4440

gugaagaacg ugcuuucgcg ccacuacgug caucuggaac ggagccccug gaaggggcuc     4500

cccgagcuga ccaacgagaa cgcccaguac ugucccuucu ccugugaaac ccaggcuugg     4560

uccauugcca ccauucugga aacccuguac gaccucuag                            4599


<210>  15
<211>  4599
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Codon-Optimized AGL Coding Sequence

<400>  15
augggacacu caaagcaaau ucggauccuc cugcucaacg agauggaaaa gcucgagaaa       60

acccucuuuc gccuggagca ggguuaugag cuccaguucc gccugggucc gacccuccaa      120

gggaaggccg ucacugugua cacuaacuau ccauuccccg gagagacuuu caaccgggaa      180

aaguuccgca gccucgauug ggagaacccu acugaacggg aggacgauuc ggacaaguac      240

uguaaacuga accuccagca gagcggcuca uuucaauacu acuuucugca agggaacgag      300

aaguccggag ggggguacau cgucguggau ccuauccuuc gcgugggcgc cgacaaccau      360

gugcugccgu uggacugcgu gacccugcaa accuuccucg ccaaaugccu cggaccuuuc      420

gaugaguggg aauccaggcu gagaguggcc aaggaaucgg gguacaacau gauucacuuc      480

accccucucc aaacccuggg ccugucucgg agcugcuacu cccuggccaa ccagcuggag      540

cugaaucccg acuucucccg gcccaaccgg aaguacacuu ggaaugacgu gggccaacug      600

guggagaagc ucaagaagga guggaacgug aucugcauua ccgacguggu guacaaccau      660

accgccgcca acuccaagug gauccaggaa cacccagaau gugccuacaa ccucgucaac      720

ucaccccacc ugaaaccagc augggugcug gaucgcgccc ucuggcgguu cucgugugac      780

guggccgaag gaaaguacaa agagaagggc aucccugccc ugaucgaaaa ugaccaccac      840

augaauucca uuagaaagau cauuugggag gacauuuucc cuaaguugaa gcucugggag      900

uucuuccaag uggacgucaa caaggccgug gaacaguuuc gccggcuccu gacccaagaa      960

aaccgccgcg ugaccaaguc cgacccuaac cagcaccuga ccauaaucca ggacccugag     1020

uacagacggu ucgguugcac ugucgacaug aacaucgccu ugacuacuuu caucccgcac     1080

gacaaggguc cugccgccau ugaggagugc ugcaacuggu uccacaagcg gauggaagaa     1140

cugaacuccg aaaagcaccg ccucaucaac uaccaccagg agcaggccgu gaacugccug     1200

cuggggaacg uauucuacga gaggcuggcc ggacacggac ccaagcuggg acccgugacc     1260

agaaagcauc cucucgucac ccgcuacuuu acuuucccgu uugaagagau cgacuucuca     1320

auggaagagu cgaugaucca ucucccuaac aaggccugcu uccugauggc ccacaacggc     1380

ugggugaugg gcgacgaucc ucugagaaac uucgcugagc ccgguucgga aguguaccuu     1440

agacgggaac uuauuugcug gggcgauucc gugaaguuac gcuacggaaa caagccugag     1500

gacugcccuu accugugggc ccauaugaag aaguacaccg agauuaccgc caccuacuuc     1560

caaggggucc ggcuggacaa cugccacuca acuccucugc acguggcuga guacaugcug     1620

gaugcggccc ggaauuugca gccuaaccuu uacguggucg ccgaacucuu uaccgggucc     1680

gaggaccugg acaacguguu cgugacucgg cucggaaucu ccucacugau uagagaggcc     1740

auguccgcau acaacucgca cgaagaaggc cggcuggucu aucgauacgg cggcgaaccu     1800

gucggaagcu ucguccagcc cugccugcgg ccgcugaugc cagcgaucgc ccacgcccuc     1860

uucauggaca ucacccauga caacgaaugu cccaucgugc accgcuccgc cuacgaugcc     1920

uugccaagca ccaccaucgu guccauggcg ugcugcgcca gcgguagcac uaggggcuac     1980

gaugaacuug ugccgcacca gaucagcgug guguccgagg aaagguuuua cacgaagugg     2040

aaccccgaag cccugcccuc caacacuggg gaagugaacu uccaguccgg gaucauugcg     2100

gcccgcugcg cgaucucgaa gcuccaccag gaacucggcg cgaaaggauu cauucaaguu     2160

uacguggacc aggucgacga ggacaucguc gccgugacuc gccacucccc uucaauccau     2220

caauccgugg uggcgguguc gcggaccgcu uuccggaacc cuaagacuuc guucuacucg     2280

aaagaagugc cucagaugug uauccccgga aagaucgagg aaguggugcu cgaggccagg     2340

acuauugaga ggaauaccaa gccuuaccgg aaggaugaga acuccauuaa cgguacuccu     2400

gacaucaccg ucgagauccg ggaacacauc cagcucaacg aaagcaaaau cgugaagcag     2460

gccggcgugg ccacuaaggg uccgaacgag uacauccagg aaaucgaauu ugagaaccug     2520

ucgcccggaa gcgugauuau uuuucgggug ucccuggacc cgcacgccca agucgccgug     2580

gguauccugc gcaaucaucu gacucaguuc agcccucacu ucaaguccgg cagccuugcc     2640

guggacaacg ccgauccgau ccugaagauc ccauucgccu cacucgccuc acggcucaca     2700

cuggccgaac ucaaucagau ccucuaucgc ugugaauccg aagagaagga ggacggcgga     2760

gguugcuacg auauuccgaa uugguccgca cugaaauacg ccggacugca gggccucaug     2820

uccguguugg ccgaaauccg cccuaagaac gaccucggcc acccguucug caacaaccuc     2880

agaucuggag acuggaugau cgauuacgug ucaaaccgcc ugaucucgag guccggcacu     2940

aucgccgaag ucggaaagug gcuccaagca auguucuucu accugaagca gaucccucgc     3000

uaccugauac cuuguuacuu cgacgccauc cucauuggcg ccuacacuac ucugcuggau     3060

acugccugga agcaaaugag cagcuucgug cagaacggaa gcacuuucgu caagcaucug     3120

ucgcucggga gcgugcagcu gugcggcguc ggaaaguuuc cuucccugcc cauucugucc     3180

ccugcccuca uggaugugcc guaccgccuu aacgagauca cuaaggagaa ggagcagugu     3240

ugcgugagcc uggcugccgg gcucccucac uucucguccg gaaucuucag augcuggggc     3300

cgcgacaccu ucauugcccu gcgagggauc cuguugauua cuggccgcua cguggaggcc     3360

aggaauauca uucucgccuu cgcgggaacc cugcggcacg gccugauccc uaaccuccug     3420

ggagaaggaa ucuaugcgag auauaacugc agggacgccg ugugguggug gcuccagugc     3480

auccaggacu acugcaagau ggugcccaac gggcuggaca uccucaagug ccccguguca     3540

cggauguacc caacugauga cagugcuccu cugccggccg guacucucga ccagccacuc     3600

uuugaaguca uccaggaggc caugcagaag cacaugcagg gcauucaauu ccgggagagg     3660

aacgccggac cucagauuga ccggaacaug aaggacgagg guuucaauau cacugccggc     3720

guggacgaag aaaccggcuu cgucuacgga ggaaacagau ucaacugcgg aaccuggaug     3780

gauaagaugg gagaaagcga cagagcgcgg aacaggggua ucccugccac uccccgggac     3840

ggaucggccg uggaaauugu gggacuuucc aaguccgccg ugcgguggcu ccuggagcuu     3900

uccaagaaga acaucuuccc uuaccaugaa gugaccguga agcggcacgg gaaggccauc     3960

aaagucuccu acgaugaaug gaaccgcaag auucaggaca auuucgagaa gcuguuccau     4020

gucuccgagg acccuucuga ccugaaugag aagcauccca accuggugca caagagaggc     4080

aucuacaagg acagcuacgg agcuuccucc ccuuggugcg auuaccagcu ccggccaaac     4140

uucacuaucg ccaugguggu ggcgccugaa cuguucacca cugaaaaggc cuggaaggcg     4200

cucgaaaucg cggagaagaa gcugcucggg ccucucggga ugaaaacccu cgacccugau     4260

gauauggugu acugcggaau cuacgauaac gcccuagaca acgacaacua caaccuggcc     4320

aagggauuca acuaccauca ggggcccgag ugguuguggc cuauuggcua cuuccugaga     4380

gccaagcucu acuucucccg ccucaugggc cccgaaacca cugccaagac caucgugcuc     4440

gugaagaacg ugcucucccg gcacuaugug caccuugagc gcucgccaug gaagggacug     4500

cccgaacuga cuaacgagaa cgcccaguac ugccccuucu ccugugaaac ucaggccugg     4560

uccaucgcca caauuuugga aacccucuac gaucuguag                            4599


<210>  16
<211>  4599
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Codon-Optimized AGL Coding Sequence

<400>  16
augggacauu caaagcaaau ccggauucug uuacuuaaug agauggagaa guuggagaaa       60

acauuguuua gacucgagca gggcuacgaa cugcaguuuc gccugggccc uacacuacaa      120

gggaaagccg ucaccgucua uacaaacuau cccuuccccg gcgaaacguu uaaucgggag      180

aaguucagau cucuggauug ggagaacccc accgaacggg aggaugauag cgacaaguau      240

ugcaaacuga acuugcagca gucuggcagu uuucaguauu auuuucugca agggaacgag      300

aaguccggcg gcggcuauau aguggucgac cccauccuuc gugugggagc ugacaaccau      360

guguugcccc uggacugugu uacacugcaa accuuucugg cuaagugucu cgguccuuuu      420

gaugaauggg aaucgcggcu caggguggca aaagaauccg gcuauaacau gauucauuuu      480

acaccccugc aaacccuggg ccucucaagg aguuguuaca gccuugccaa ucagcuggag      540

cugaaccccg acuuuucccg ucccaaccgg aaguauacuu ggaacgacgu gggccagcuc      600

guagaaaagc ugaaaaagga guggaacgug aucuguauaa ccgauguggu cuauaaccac      660

accgccgcca auucgaagug gauccaggag caucccgagu gugcuuacaa ccucgugaac      720

agcccccauc uuaagcccgc uuggguacuu gaccgcgcac uuuggagguu uuccugugac      780

guggcugagg ggaaguauaa ggaaaagggc auccccgccc ugaucgaaaa cgaccaucac      840

augaacagua uacggaagau cauuugggag gauauuuuuc ccaaacugaa gcugugggag      900

uuuuuucaag uggaugugaa caaggcuguc gaacaguuua ggaggcugcu gacccaagaa      960

aauagacgcg ugacuaagag cgacccaaau cagcauuuga caauuauaca ggaccccgaa     1020

uaucgccgau ucggcuguac cguggauaug aauaucgcau ugacuacuuu caucccccac     1080

gacaagggcc ccgccgcuau ugaggaaugc uguaauuggu uucauaagcg aauggaggag     1140

cugaacucug agaagcacag gcugauuaac uaucaucagg aacaggccgu uaacuguuug     1200

cugggcaacg uguuuuauga acggcuugcc ggccauggcc cgaaguuggg cccgguuaca     1260

agaaagcauc cacuugugac ccgcuacuuc accuuuccgu ucgaagaaau ugacuuuagc     1320

auggaggagu caaugaucca ccuccccaac aaggcuugcu uucuuauggc ucacaacggc     1380

ugggugaugg gcgacgaccc ccugcggaac uuugcggaac cgggcucaga ggucuaucua     1440

agaagggaac ugauuugcug gggcgacucc gugaagcuga gauacgggaa caagccugag     1500

gauugccccu accucugggc ucacaugaaa aaguauacag aaauuacugc uacguauuuc     1560

caaggcguac ggcuugacaa cugucacucc accccacugc augucgccga guauauguua     1620

gaugcugcuc gaaacuugca gcccaauuug uauguggucg cugaacuguu uacggggagu     1680

gaagaucucg acaacgucuu uguaacccga cugggcauca gcucgcuaau ucgggaggcc     1740

auguccgcuu acaacuccca ugaggaaggc cgccuuguau aucguuaugg cggcgaaccc     1800

guggggagcu uuguucaacc gugucuacgc ccccugaugc ccgccaucgc ucaugcccua     1860

uucauggaua ucacucauga caaugagugu ccuauugugc auaggagugc uuaugacgcc     1920

cucccaagca caacgaucgu guccauggcu uguugugcua guggcuccac aagaggcuau     1980

gacgaacugg ugccccauca aaucuccgua gugucugaag agagauuuua caccaagugg     2040

aaccccgagg cucucccuuc aaacacugga gagguuaacu uucaauccgg gauuauugcu     2100

gcuagaugug cuaucagcaa gcuccaucag gaacugggcg caaagggcuu cauucaaguu     2160

uauguagacc agguugacga ggacauaguu gcaguaacuc ggcauucccc uucgauacau     2220

cagucugucg uggccguguc caggacagca uuucgcaauc ccaagacuag cuuuuacucc     2280

aaagaaguac cacaaaugug uauccccggg aagaucgagg aagugguacu ggaagcccgg     2340

acuauugaga gaaacaccaa gccguaucgg aaggacgaga auucuaucaa cggcacaccu     2400

gauauaacag uggaaauacg cgaacacauu caguugaaug aguccaagau cgugaagcag     2460

gccggcgucg ccaccaaggg ccccaacgag uauauccagg agaucgaauu ugaaaaccug     2520

agccccggcu cuguuauuau auuucggguu ucauuagauc cucaugcuca aguggcugua     2580

ggcauccucc ggaaucaucu gacucaguuc ucuccccacu ucaagagcgg cagccuggcu     2640

gucgauaaug ccgaccccau acuuaagauu cccuuugcuu cccuggcuuc aaggcugacc     2700

cuggcugaac uuaaucaaau ccuauaccga ugcgaaagcg aagagaagga agauggcggc     2760

ggcuguuacg auaucccgaa cuggagcgca cugaaauaug cuggcuuaca aggccucaug     2820

aguguguugg cugagauuag acccaagaau gacuugggcc auccauuuug uaacaaccug     2880

agaagcggcg acuggaugau cgauuacgug ucuaaccgac ucaucucccg aagcggcacc     2940

auugcugagg uuggcaaaug gcugcaggcu auguucuuuu aucugaaaca gauuccucgg     3000

uaccugauuc ccuguuauuu cgacgcuauu cugauuggcg cauauaccac gcucuuggac     3060

acugcaugga agcaaaugag cucuuuuguc caaaauggcu ccacuuuugu uaaacaucug     3120

aguuugggca gcgugcaguu auguggcguu ggcaaauuuc caagccugcc cauacugucc     3180

cccgcucuga uggacguccc cuaccgacug aacgagauca ccaaggaaaa ggaacagugc     3240

ugugugucuu uagcugccgg cuugccgcau uuuucaagcg gcauuuuccg guguuggggu     3300

cgggacaccu ucaucgcacu gagaggcauu cugcugauca cuggccgcua uguggaagcu     3360

aggaauauca uuuuagccuu ugcggguacc cuucggcacg ggcugauccc caaucuuuug     3420

ggcgaaggca ucuacgcacg uuacaauugc cgggaugccg uaugguggug gcuccaaugu     3480

auccaggacu auugcaagau gguucccaac ggccucgaua uccugaagug ccccguguca     3540

aggauguauc cuaccgauga cagugcuccc cuuccugcug gcacccugga ucagccgcuc     3600

uuugaaguua uucaggaagc aaugcaaaag cauaugcagg gcauccaguu ucgggaaaga     3660

aacgcuggcc cgcaaauaga caggaacaug aaggaugaag gcuucaauau uacugcuggc     3720

guagacgaag agacaggguu cgucuacggc ggcaauaggu uuaacugugg cacuuggaug     3780

gacaagaugg gcgaaucuga ccgcgcgagg aacagaggca ucccagcaac accgagggac     3840

ggcagcgcug uggagauugu gggccugucu aagucugccg ugcgcuggcu acucgaacug     3900

uccaagaaga auaucuuucc cuaucaugaa gucaccguaa agcggcaugg caaagcuauu     3960

aagguuuccu augacgagug gaacaggaag auucaggaca auuuugagaa gcuguuccau     4020

gugucggagg acccuagcga ucucaacgag aagcacccca acuuaguaca uaagaggggc     4080

aucuauaagg auagcuaugg cgcuagcagc ccuuggugug acuaucagcu ccgucccaac     4140

uuuaccauug cuaugguagu ggcgcccgag uuguuuacca cugagaaggc uuggaaggcu     4200

cuugaaauag ccgagaagaa auugcugggc ccccugggca ugaaaacucu ggaucccgau     4260

gacaugguau acuguggcau cuaugacaau gcccuggaca augacaauua caaucuggcc     4320

aaggguuuua acuaucacca gggcccugaa uggcuguggc cuauuggcua uuuucuucgc     4380

gccaagcuau auuuuaguag gcugaugggu ccagaaacaa cugcaaagac aauugugcuc     4440

gugaagaacg ugcuuucccg gcacuaugug caucuggaaa ggaguccaug gaagggcuug     4500

ccggaauuga cuaacgagaa cgcccaguau ugucccuuuu cuugugaaac ucaggccugg     4560

uccauugcua cuauucugga gacucuauau gacuuguag                            4599


<210>  17
<211>  4599
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Codon-Optimized AGL Coding Sequence

<400>  17
augggccauu ccaagcaaau ucgaauucug cugcugaacg aaauggaaaa guuggaaaag       60

acauuguucc gucuggagca gggcuaugag cugcaguuua ggcuuggccc gacguugcag      120

ggcaaagccg ugaccguaua uacuaacuau cccuucccug gcgaaacguu uaaccgggag      180

aaguuucgcu cacuggacug ggagaauccc acggaaaggg aggacgauag cgauaaguac      240

uguaaacuga aucugcaaca gucuggcucu uuccaauauu auuuucugca agggaacgag      300

aaguccgggg gcggcuauau uguaguggac cccaucuuga gagugggcgc ugacaaccau      360

guauuacccc uugauugcgu gacgcugcag accuuucugg cuaaguguuu gggcccuuuc      420

gaugaguggg aaagccggcu gaggguggcc aaggagagcg gcuauaauau gauucauuuu      480

accccuuugc aaacucuggg gcucucuagg agcuguuauu ccuuggcuaa ucagcuggaa      540

cugaaccccg auuuuagccg gcccaaccga aaguauacau ggaaugacgu ugggcaauug      600

guugagaagc ugaagaagga auggaauguu auauguauaa cagacguggu guauaaccau      660

accgcugcua auucgaaaug gauucaggaa cauccugagu gcgccuacaa ccucguaaau      720

aguccucauc ugaagccggc uugggugcug gacagggcuc ucuggagguu uagcugugau      780

guggccgaag ggaaguauaa ggagaagggu aucccggcuc ugauugagaa cgaccaccau      840

augaacagua uaaggaagau aaucugggag gacauuuuuc ccaaacugaa gcugugggaa      900

uucuuucaag uggacgugaa caaggccguu gagcaguuua gacgcuugcu gacacaagag      960

aaccgaaggg ucaccaagag ugacccuaac cagcaucuua caauuaucca agaccccgag     1020

uaucgucggu uuggcuguac uguggacaug aacauugcuc ugaccaccuu uauaccccac     1080

gauaagggcc ccgcugcuau cgaagagugu uguaacuggu uccacaagag gauggaagag     1140

uugaacucug aaaagcaucg gcugauuaac uaucaucagg aacaggcugu gaacugccug     1200

cucggcaacg uauucuacga gagauuggcu ggccauggac cuaagcuggg cccgguuacg     1260

agaaagcauc cccugguuac gcgguauuuc accuucccgu uugaggagau ugauuuuagc     1320

auggaagaau ccaugaucca ccuccccaac aaggcuugcu uccugauggc acauaacgga     1380

uggguuaugg gcgacgaccc ccugaggaau uuugcugaac ccggcuccga agucuaucug     1440

agaagggaac ugaucuguug gggcgacucc gucaaguugc gcuauggcaa uaagccugag     1500

gacuguccau aucugugggc ucacaugaag aaguacacag agaucaccgc uacauacuuu     1560

cagggcguca ggcucgacaa uugucacucc acaccccugc acguggcuga guauaugcug     1620

gaugccgcua ggaaucucca gccuaaccua uauguggucg cugaacuguu caccggcucu     1680

gaggaucugg auaauguguu ugugacacgc cugggcauca gcucccugau ccgcgaggcu     1740

augagugccu acaauaguca cgaggaaggc cggcuugugu accgcuaugg cggcgaaccc     1800

gugggcagcu uuguacaacc uugucugcgg ccucugaugc ccgcuauugc ucacgcuuug     1860

uuuauggaca ucacccauga caacgaaugu cccauuguac accggucugc uuacgacgcu     1920

cugcccucca caacuauugu caguauggcu uguugugcau cuggcucaac ucggggcuac     1980

gacgaauuag uuccgcauca aaucucugua guguccgaag aacgguuuua uacaaaaugg     2040

aaccccgaag cgcugcccuc caauaccggc gaagugaacu uucagucugg gaucaucgcc     2100

gcuagaugug cuauuucuaa acugcaucag gaacugggcg cuaagggcuu uauucaagua     2160

uauguggacc aggucgacga ggacaucgua gcuguaaccc ggcacagccc cagcauacau     2220

cagagugucg uggcuguguc uagaacagcu uuuaggaacc caaagaccuc uuuuuacucc     2280

aaagagguuc cacagaugug uaucccgggc aaaauugagg aaguggucuu ggaggccagg     2340

acaauugagc guaauacgaa gcccuauaga aaggaugaga auagcaucaa cggcacuccu     2400

gauaucacug uggaaauccg ggagcauaua caguugaacg agucuaagau cguuaagcag     2460

gcugguguag cuaccaaggg ucccaaugag uauauucagg aaauugaguu ugaaaaccug     2520

uccccgggca gcguaauuau cuuuagaguc agucucgacc cccaugcuca aguggcagug     2580

gggauccugc ggaaccauuu gacucaguuc uccccccauu uuaagucugg cagucuggcc     2640

guugacaacg cugaccccau auugaagauu cccuuugcuu cccuggcuuc acgguugacc     2700

cuggccgaac ugaaccagau uuuauaucgc ugcgaguccg aggaaaagga ggauggcggc     2760

ggcuguuaug acauucccaa cuggucugcu cuaaaauacg cugggcugca gggucugaug     2820

agugugcugg cugaaauucg ccccaagaac gaccugggcc auccauuuug caacaaucug     2880

cgcaguggcg acuggaugau ugauuaugug uccaaccggc ugauuagucg gagcggcacg     2940

aucgcagaag ucggcaaaug gcuccaggcu auguuuuuuu accuaaagca gauacccaga     3000

uaccugaucc cuuguuauuu ugacgcuaua cugauuggcg cuuacacaac cuugcuggac     3060

accgccugga agcagaugag cagcuuuguc caaaauggca gcacauucgu gaagcauuug     3120

ucucugggca gugugcagcu guguggcgug ggcaaauuuc caaguuugcc gauccugucu     3180

cccgcuuuga uggaugugcc auaucgacug aacgagauaa ccaaggaaaa ggaacagugu     3240

uguguuucac ucgcugcugg cuugccccau uuuuccucug gcauuuuccg auguuggggg     3300

agggacacau ucauugcccu gcgugggauc cugcugauua ccggccgcua cguugaggcu     3360

agaaacauua uuuuggcuuu cgccggcaca uugagacaug gucugauacc caaucugcug     3420

ggcgaaggca uauaugcuag guauaacugu cgcgacgcag ugugguggug gcugcaaugc     3480

auccaggauu auugcaagau gguuccuaac ggccuagaca uccugaagug cccagugucc     3540

cggauguauc caaccgauga uucagcuccc cugcccgccg guacacugga ccaaccccug     3600

uucgaaguua uucaagaagc caugcagaag cacaugcagg guauccaguu ucgagagagg     3660

aaugcaggcc cccaaauuga ccggaacaug aaggaugaag gcuucaacau uacugcuggc     3720

gucgacgaag aaacaggguu uguguacggc ggcaaccggu uuaacugcgg cacauggaug     3780

gacaagaugg gcgaaagcga ucgcgcacgg aaccggggca uccccgccac gccgcgugau     3840

ggcucugcug uggagaucgu cggccucagc aaauccgcug uccgauggcu guuagagcug     3900

ucgaagaaga acaucuuucc cuaccaugag guuaccguua agagacacgg caaagcuauc     3960

aaagugucuu augacgaaug gaauagaaag auucaagaca acuucgagaa acuguuucau     4020

guguccgagg aucccagcga ccucaacgaa aagcauccca aucucguaca uaagaggggc     4080

aucuauaagg acucauaugg cgcaucaagu ccuuggugcg acuaucagcu ucggcccaau     4140

uucacgaucg caauggucgu ggcacccgag cuguuuacua cggagaaggc uuggaaggcu     4200

cuggaaaucg cugagaagaa gcugcugggc cccuugggca ugaaaacccu ggaucccgac     4260

gacaugguau acuguggcau auaugacaac gcucuggaua acgauaacua uaauuuggcu     4320

aaaggcuuua auuaucacca gggcccagaa uggcuauggc ccauuggcua cuuucugcga     4380

gcuaagcuau auuuuucucg ccugaugggc ccugaaacca ccgcuaagac uaucgugcuc     4440

gucaagaacg uacugaguag gcauuacgug cacuuggagc gcagcccaug gaagggcuug     4500

ccggaacuga cgaacgaaaa cgcucaguau uguccguuuu cuugugaaac acaggcuugg     4560

aguauugcua cuauccugga aacucuguac gaucuguag                            4599


<210>  18
<211>  4599
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Codon-Optimized AGL Coding Sequence

<400>  18
augggucauu ccaaacaaau uaggauccug cuguugaacg aaauggaaaa gcucgaaaag       60

accuuauuuc gccuggagca gggcuaugag uugcaguuuc ggcugggacc aacucugcaa      120

ggaaaggcug uaaccgugua cacaaauuau ccuuuucccg gcgaaacguu uaacagggag      180

aaguuucgau cucuggauug ggagaacccc acugaaaggg aggacgauag cgacaaguau      240

ugcaaacuga aucugcaaca guccggcagc uuucaauauu auuuucugca agggaacgaa      300

aagagcggcg ggggcuauau uguaguagac ccuauacuga gagucggagc ugacaaccau      360

guucugcccu uggacugcgu gacacugcag accuuuuugg cuaagugucu gggccccuuu      420

gaugaauggg agagucggcu ccguguggcu aaggagagcg gguacaauau gauucacuuu      480

accccccugc aaacuuuggg acuuucccgg agcuguuaua gccuggcaaa ccagcuggag      540

uugaauccug acuuuucccg cccaaauagg aaguauaccu ggaacgacgu gggccaacug      600

guggagaagc ugaagaagga guggaacgug aucugcauua ccgacgucgu guauaaucau      660

accgccgcca acuccaagug gauacaggaa cauccugagu gugcuuacaa ccucguaaac      720

uccccgcauc ugaagccagc uuggguucug gauagagcuu uguggcgguu cagcugugac      780

gucgcugagg gaaaguacaa ggaaaaaggg auuccugcuc ucaucgagaa ugaccaccac      840

augaacagua uuaggaagau uaucugggag gacaucuucc cgaagcuaaa gcugugggaa      900

uucuuccaag uggacgugaa caaggccgug gagcaguucc gacggcuguu aacucaagag      960

aaccguaggg ucacaaaauc ggauccuaac cagcaccuga ccauuaucca agacccggaa     1020

uaucggcggu ucggcuguac uguggacaug aacauugcuu ugacaacuuu cauuccccac     1080

gacaaggguc cagcagcuau cgaggaaugu uguaauuggu uucauaagcg gauggaggaa     1140

cucaacuccg agaagcauag gcugauuaau uaucaucagg aacaggcugu gaauugucug     1200

uugggcaaug uuuucuacga acggcuggcu ggccauggcc ccaaacucgg accuguuaca     1260

aggaagcauc cacugguuac ccgauacuuu accuuuccau uugaagaaau ugauuuuagc     1320

auggaagaau ccaugaucca ucuaccuaac aaggccuguu uucugauggc ccauaacggc     1380

uggguuaugg gagaugaucc cuugcggaac uuugcugaac ccggaucuga aguauaucug     1440

cggagagagu ugauuuguug gggcgacucc guaaagcugc gcuauggcaa caagccagag     1500

gacugucccu auuugugggc ucauaugaag aaguauaccg agaucaccgc uacguauuuu     1560

caaggcguca ggcucgauaa uugucauucc acuccgcugc auguugcuga guauauguug     1620

gacgcugcuc gaaaucugca gcccaauuug uauguugugg ccgagcuguu uaccggcucc     1680

gaggaccucg auaacguguu cgucacgcga cuaggcauca gcagcuugau ccgggaagcc     1740

auguccgcuu auaacuccca cgaggagggc cgacuggucu accgcuaugg cggcgaacca     1800

gugggcaguu uuguacagcc uugucugagg ccccucaugc ccgcuauugc ucaugcucug     1860

uucauggaca uuacucauga uaacgagugc ccuauagugc aucgguccgc cuacgacgcc     1920

cugccgagca cuacaauagu guccauggcu uguugugcaa gcgggagcac ccgcggcuau     1980

gacgagcugg ugccgcauca aauaucugua gucagcgaag aaagguuuua uaccaagugg     2040

aacccggaag cuuuaccuuc caauacuggg gaagugaacu uucagagcgg cauuaucgcu     2100

gcgagaugug cuauauccaa guugcaucag gaacuggggg caaagggguu uauucaagua     2160

uauguagacc agguugacga agauauagug gcugugacac gccacagccc aagcauccac     2220

caguccgugg uggcugucag ccggacugcu uuucgcaacc caaagacaag cuuuuauagc     2280

aaagaagugc cgcagaugug cauucccggc aaaauugagg aggucgugcu ggaggcuagg     2340

acuaucgaaa ggaacaccaa gccguacagg aaggacgaga auuccaucaa cgggacucca     2400

gauauuacag uugagauccg ggaacauauu caguugaaug agucgaagau uguuaagcag     2460

gcuggcguag cuacaaaggg gccaaacgag uauauucaag agauagaauu cgaaaaccug     2520

agccccgguu ccgugaucau uuuucgagug ucccuggauc cucaugcuca aguggccguu     2580

ggcauucuga gaaaccaucu cacacaauuu uccccucacu uuaaaagugg cagccuggcu     2640

guggacaacg ccgauccgau ccugaagauu ccauucgcuu cccuggcuag ucgccugaca     2700

cuggcugaac uaaaccagau ucuuuaccgc ugugaaucug aagagaagga ggacggcggc     2760

gguugcuaug acaucccaaa uuggagcgcu cugaaauacg cugggcugca gggccucaug     2820

agcguacugg cagaaaucag acccaagaac gaccugggcc accccuucug uaacaaccug     2880

agguccggcg auuggaugau cgacuaugug ucgaacagac ucaucucaag aagcggcacu     2940

auagcugagg ucggcaaaug guugcaggcu auguucuuuu aucugaagca aauuccgcgg     3000

uaucugaucc cgugcuauuu ugacgcuaua uugaucggcg cuuauacgac uuugcuggac     3060

acagccugga agcagauguc cagcuucgug cagaacggca gcacuuuugu gaagcaccug     3120

agucugggcu caguacagcu guguggcgug ggcaaauucc ccagccuacc aauucugucc     3180

cccgcucuga uggauguucc cuaucggcug aacgagauua ccaaggaaaa ggagcaaugu     3240

ugcgugagcc uggcagccgg ccugccccac uuuucuuccg gcauuuuucg cuguuggggu     3300

cgggacaccu ucauugcacu gcggggcauc cuguuaauca ccggccgcua uguggaagcu     3360

agaaauauua ucuuggcuuu ugcuggcacu cugcgacacg gccugauccc caaccuucug     3420

ggcgaaggca ucuaugcucg cuacaauugu cgcgacgccg ucugguggug gcugcagugu     3480

auacaggacu auugcaagau ggugccaaau ggccuggaca uccuuaaaug uccaguuucc     3540

cggauguacc caacugacga cagcgcuccu uugccugccg gcacacugga ucagccgcug     3600

uuugaaguga uccaggaagc uaugcagaag cauaugcagg gcauucaguu ucgggaacga     3660

aaugcuggcc cacaaauuga cagaaacaug aaggaugagg guuuuaacau uacugcuggc     3720

gucgaugaag agacaggguu uguguacggc ggcaacaggu ucaacugcgg cacauggaug     3780

gacaagaugg gcgaaucuga ccgugcuagg aacaggggaa uccccgcuac cccccgggac     3840

ggcagcgcug uggaaaucgu aggccugucc aaguccgccg uucgcuggcu ucuggagcug     3900

agcaagaaaa acaucuuucc cuaucacgag gucacaguga agagacaugg caaagcuauc     3960

aaagucucuu acgaugagug gaauagaaag auucaagaua acuuugaaaa guuguuccac     4020

guuucggagg accccagcga ucugaaugag aagcauccca acuuggugca caagaggggc     4080

auauacaagg acucuuaugg ugcuagcagc ccuuggugcg acuaucagcu gaggcccaac     4140

uuuacuaucg ccaugguggu ggcaccggaa cuguuuacaa cggagaaggc uuggaaggcu     4200

cuggaaauug cugagaagaa guugcugggg ccccugggga ugaaaacgcu ggauccagac     4260

gacauggucu acuguggcau auaugauaau gcucuggaua acgauaauua caaucuggcu     4320

aaggguuuca acuaucauca ggggccagag uggcucuggc cuauuggcua uuuccuccgu     4380

gcuaagcugu acuuuucucg ccugaugggg ccagaaacua ccgcaaagac cauuguauug     4440

gucaagaacg ugcugagccg gcauuaugua cauuuggaac gguccccuug gaaaggccug     4500

cccgaacuca cuaacgagaa cgcucaguau uguccguuuu ccugcgaaac ccaggcuugg     4560

uccaucgcaa cuauuuugga aacccuguac gaccuguag                            4599


<210>  19
<211>  4599
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Codon-Optimized AGL Coding Sequence

<400>  19
augggccaca gcaagcaaau cagaauccuc cugcucaacg agauggaaaa gcucgaaaag       60

acccuguuca gacuggagca gggauacgag cugcaguucc gccucggacc aacccuccaa      120

gggaaggccg ugaccgugua caccaacuac ccauucccgg gagaaaccuu caaccgggaa      180

aaguucagga gccuggacug ggaaaacccc accgagagag aggacgacag cgacaaauac      240

ugcaagcuga accuccaaca gagcggcagc uuccaguacu acuuccucca aggaaacgaa      300

aagagcgggg gcggcuacau cgugguggac ccaauccugc gggucggggc agacaaccac      360

gugcugccac uggacugcgu gacacugcag accuuccugg ccaagugccu gggaccguuc      420

gacgaauggg agagccggcu gcggguggcc aaggagagcg gcuacaacau gauccacuuc      480

acaccgcucc aaacccucgg ccugagcaga agcugcuaca gccuagccaa ccagcuggag      540

cucaacccgg acuucagcag gcccaacaga aaguacaccu ggaacgacgu gggacagcuc      600

guggaaaagc ugaaaaagga auggaacgug aucugcauca ccgacguggu guacaaccac      660

accgccgcca acagcaaaug gauccaggaa cacccggaau gcgcguacaa ccucgugaac      720

agcccccacc ugaagccggc cuggguacug gacagggcac uguggcgcuu cagcugcgac      780

guggccgaag gaaaguacaa ggagaagggc auccccgccc ugaucgagaa cgaccaccac      840

augaacagca uccggaagau caucugggag gacaucuucc caaagcugaa gcugugggag      900

uucuuccaag ucgacgugaa caaggccgug gaacaguuca gacgccugcu gacgcaggag      960

aaccggaggg ucaccaagag cgaccccaac cagcaccuga ccaucaucca agacccggaa     1020

uaccggagau ucggaugcac cguggacaug aacaucgccc ugaccaccuu caucccacac     1080

gacaaggggc ccgcagccau cgaggagugc ugcaacuggu uccacaagag aauggaggaa     1140

cugaacagcg aaaagcaccg ccucaucaac uaccaccagg aacaggccgu gaacugccuc     1200

cucggaaacg uguucuacga gcggcuggcc ggccacgggc ccaagcuggg ccccgugacc     1260

cgcaagcacc cgcucgugac gcgguacuuc accuucccgu ucgaagaaau cgacuucagc     1320

auggaggaga gcaugaucca ccucccgaac aaggccugcu uccucauggc ccacaacggc     1380

ugggucaugg gcgacgaccc gcugcggaac uucgcagagc ccggaagcga aguguaccuc     1440

agaagggagc ugaucugcug gggagacagc gugaagcugc gcuacggaaa caagcccgag     1500

gacugcccgu accugugggc gcacaugaag aaguacaccg agaucaccgc caccuacuuc     1560

caaggagugc ggcuggacaa cugccacagc accccgcugc acguggccga guacaugcug     1620

gacgccgcca gaaaccucca gcccaaccuc uacguggugg cagagcuguu caccgggagc     1680

gaggaccucg acaacguguu cgugacccga cucggcauca gcagccugau ccgggaagca     1740

augagcgccu acaacagcca cgaggaaggg aggcuggugu acagauacgg aggagaaccc     1800

gugggcagcu ucgugcagcc gugccugagg ccccugaugc cagccaucgc gcacgcgcug     1860

uucauggaca ucacccacga caacgaaugc ccgaucgugc accggagcgc auacgacgcc     1920

cugccgagca ccacgaucgu cagcauggcc ugcugcgcca gcggcagcac ccgaggauac     1980

gacgagcugg ugccccacca aaucagcguc gucagcgaag aacgcuucua caccaagugg     2040

aacccggaag cacugccgag caacaccgga gaagugaacu uccagagcgg aaucaucgcc     2100

gcgcgcugcg cgaucagcaa acugcaccag gaacugggag ccaagggguu cauccagguc     2160

uacgucgacc aaguggacga ggacaucgug gcagugaccc gccacagccc cagcauccac     2220

caaagcgugg uggccgugag ccggacagcg uuccggaacc ccaagacgag cuucuacagc     2280

aaagaggugc cccagaugug caucccggga aagaucgagg aaguggugcu cgaagcgcgc     2340

accaucgaac gcaacaccaa accguaccgc aaggacgaaa acagcauaaa cgggaccccc     2400

gacaucaccg uggagaucag ggaacacauc cagcugaacg agagcaagau cgugaagcag     2460

gccggggucg ccaccaaggg cccgaacgag uacauccagg agaucgaguu cgagaaccuc     2520

agccccggga gcgugaucau cuucagaguc agccuggacc cacacgccca aguggccgug     2580

ggcauccucc ggaaccaccu gacccaguuc agcccgcacu ucaagagcgg gagccucgcc     2640

guggacaacg ccgacccgau ccugaagauc ccguucgcga gccuggccag ccggcucacc     2700

cuggccgaac ugaaccagau ccuguaccgc ugcgagagcg aagaaaagga ggacggagga     2760

gggugcuacg acaucccaaa cuggagcgcg cugaaauacg cgggccugca gggccugaug     2820

agcgugcugg ccgaaauccg ccccaagaac gaccugggac acccauucug caacaaccug     2880

aggagcggag acuggaugau cgacuacguc agcaacagac ugaucagccg cagcggcacc     2940

aucgccgaag ucggaaaaug gcuccaggcc auguucuucu accugaagca gaucccgcgg     3000

uaccugaucc cgugcuacuu cgacgccauc cugaucggcg ccuacaccac ccugcucgac     3060

accgccugga agcagaugag cagcuucguc caaaacggga gcaccuucgu gaagcaccuc     3120

agccugggca gcgugcagcu gugcgggguc ggaaaauucc cgagccugcc cauccugagc     3180

ccggcgcuga uggacgugcc guacagacug aacgagauca ccaaggaaaa ggaacagugc     3240

ugcgugagcc uggccgccgg acugccgcac uucagcagcg gcaucuuccg gugcuggggg     3300

cgcgacaccu ucaucgcccu gcggggaauc cugcugauca cgggccgcua cguggaggcc     3360

cggaacauca uccuggccuu cgccggcacc cugcggcacg gacugauccc gaaccuccug     3420

ggagagggga ucuacgcccg guacaacugc cgggacgccg ugugguggug gcugcagugc     3480

auccaggacu acugcaagau ggugcccaac ggccuggaca uccugaagug ccccgucagc     3540

cggauguacc cgaccgacga cagcgccccg cuccccgccg gaacccucga ccagccacug     3600

uucgaaguga uccaggaggc caugcaaaag cacaugcagg gaauccaguu cagagaacgg     3660

aacgccggac cccagaucga ccggaacaug aaggacgagg gauucaacau caccgccgga     3720

gucgacgagg aaaccggcuu cgucuacgga gggaaccggu ucaacugcgg aacauggaug     3780

gacaagaugg gagagagcga ccgcgccagg aaccgcggaa ucccagcaac cccgcgggac     3840

gggagcgcag uggaaaucgu ggggcugagc aaaagcgccg ugcgguggcu gcucgaacuc     3900

agcaagaaga acaucuuccc cuaccacgaa gucaccguga agagacacgg aaaggccauc     3960

aaagucagcu acgacgaaug gaacaggaag auacaggaca acuucgagaa gcuguuccac     4020

gucagcgagg acccgagcga ccugaacgag aagcacccca accuggugca caagcgcggg     4080

aucuacaagg acagcuacgg cgcgagcagc ccguggugcg acuaccaacu gcgccccaac     4140

uucaccaucg ccauggucgu ggcccccgaa cucuucacga ccgagaaagc guggaaggcg     4200

cuggagaucg cggaaaagaa gcuccucgga ccccugggga ugaaaacccu ggaccccgac     4260

gacauggugu acugcggcau cuacgacaac gcgcuggaca acgacaacua caaccuggcc     4320

aagggcuuca acuaccacca gggccccgaa uggcuauggc cgaucggcua cuuccugcgg     4380

gccaagcugu acuucagccg ccucaugggc ccagaaacca ccgcaaagac caucgugcug     4440

gucaagaacg uccugagccg ccacuacgug caccucgaga gaagcccaug gaagggacug     4500

cccgagcuga ccaacgaaaa cgcgcaguac ugcccguuca gcugcgaaac ccaggccugg     4560

agcaucgcca ccauccugga aacacuguac gaccucuag                            4599


<210>  20
<211>  4599
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Codon-Optimized AGL Coding Sequence

<400>  20
augggccaca gcaaacagau ccggauccuc cuacucaacg aaauggaaaa gcucgaaaag       60

acucuguucc ggcuggagca aggauacgag cuucaguucc gguugggccc gacgcugcag      120

gggaaggccg ugacagucua cacuaacuac ccauuccccg gcgaaaccuu caacagagag      180

aaguucaggu cccuggacug ggagaacccc acugaacggg aagaugauuc cgacaaguac      240

ugcaagcuga accuccagca auccgguuca uuccaguacu auuuccugca aggaaacgaa      300

aagagcggag gaggcuacau ugugguugau ccaauccuuc gcgugggagc cgauaaucau      360

gugcugccgc uggauugcgu cacccugcaa accuuccugg cgaagugccu gggcccguuc      420

gacgaauggg aaucccgccu gcgggucgcc aaagaguccg gguauaacau gauccacuuc      480

accccacucc aaacucuugg ccuguccaga uccugcuacu cguuggccaa ccaguuggag      540

cugaacccgg acuucucacg gccuaaccgg aaguacacuu ggaacgacgu cggacaacuc      600

guggagaagc ugaagaagga auggaauguc aucugcauua cugaugucgu guacaaccac      660

acggcggcga auucaaagug gauccaggag cacccagaau gcgccuacaa ccuggucaau      720

uccccucacc ugaagccggc cugggugcuc gaccgggccc uguggcgguu uucgugcgau      780

guggcggagg gaaaguacaa ggagaagggg auuccggcuc ucaucgaaaa cgaccaccac      840

augaacucca uccggaaaau uaucugggag gacaucuucc cgaaacuuaa gcugugggaa      900

uucuuccaag uggacgucaa caaggcugug gagcaguucc ggagauugcu gacacaagaa      960

aaccgccgcg ugaccaaauc cgauccgaac cagcaccuga cuaucauuca agacccggaa     1020

uaccggaggu uuggcugcac uguggacaug aauaucgcgc ugaccaccuu caucccgcac     1080

gacaagggac cggcagccau cgaagagugc uguaacuggu uccauaagag gauggaagaa     1140

uugaacucug aaaagcaccg gcugauuaac uaccaucagg aacaggccgu gaacugucuc     1200

cugggaaacg uguucuacga gcggcuggcg ggacacggac ccaagcucgg ccccgugacc     1260

cgcaagcauc cucucgugac uagauacuuu acuuucccau ucgaggagau cgacuucucc     1320

auggaagaau caaugaucca ccucccuaac aaggcuugcu uucugauggc acacaacggc     1380

ugggugaugg gcgaugaccc ccugaggaac uuugccgagc ccggcuccga aguguaccug     1440

aggagagagc ugauuugcug gggggacagc gucaagcugc gcuauggaaa caagccggaa     1500

gauugcccuu accucugggc ccacaugaag aaguacacug agauuacugc caccuacuuu     1560

caaggagugc gccuggauaa cugccacuca accccgcugc augucgcuga guacauguug     1620

gacgcagccc ggaaucugca accgaaccuc uacguggugg cggagcuguu caccggcucg     1680

gaggaucucg acaacguguu cgugacucgc cugggcaucu caucgcugau ccgggaagca     1740

auguccgccu acaacuccca ugaggagggu cggcuggugu accgcuacgg cggagaaccc     1800

gugggguccu ucgugcaacc gugccugcga ccccugaugc ccgccaucgc ccaugcccuc     1860

uuuauggaua uuacccacga uaacgaaugc ccuaucgugc accgcucagc cuaugaugcc     1920

cuccccucca ccaccaucgu guccauggcc ugcugcgccu cggggagcac ccgggguuau     1980

gacgagcugg ugccgcacca gauuucggug guguccgagg agagauucua caccaagugg     2040

aacccagaag cucugccguc aaacacugga gagguuaacu uucaguccgg uauuaucgcc     2100

gcuagaugug cuauuagcaa acugcaccaa gagcugggcg ccaaggguuu cauccaaguc     2160

uacgucgauc aggucgacga ggacaucgug gcugucacua ggcacucacc uagcauccac     2220

cagagcgugg uggccgugag ccgcacugcc uuccgcaacc caaagaccag cuuuuacucc     2280

aaggaggucc cucagaugug cauuccugga aagaucgaag aagugguccu ggaagcccgg     2340

accaucgaac gcaacaccaa gccuuaccgg aaggacgaaa acucgaucaa cgguaccccg     2400

gauauuacug uggagauucg cgaacacauc cagcucaaug aguccaagau cgugaagcag     2460

gccggagugg caaccaaggg gccgaacgag uacauccagg agaucgaauu cgagaaucuc     2520

agcccuggca gcgugaucau cuuccgagug ucguuggacc cacaugcuca ggucgccgug     2580

ggcauccuga ggaaccaccu gacccaguuu uccccgcauu ucaaguccgg uucgcuggcc     2640

guggacaacg cagauccgau ccugaagauc cccuucgccu ccuuggcuuc gcgccucacg     2700

cuggccgagc ugaaccagau ccuguauaga ugcgaauccg aagaaaagga agauggaggc     2760

gguuguuacg acaucccgaa cugguccgcc uugaaauacg ccggacugca gggauugaug     2820

uccgugcugg ccgaaauuag accgaagaac gaccuggggc acccguucug caacaaccuc     2880

cggucggggg acuggaugau ugauuacgug ucgaaccgcc ucaucucccg guccgguacu     2940

auugcggagg ucggcaaaug gcuccaggcc auguucuucu acuugaagca aaucccccgc     3000

uaccugaucc ccugcuacuu cgacgccauc cugaucggag ccuacaccac ccugcuggac     3060

accgcgugga agcagauguc uagcuucguc cagaacggcu ccaccuucgu gaagcaccug     3120

ucacugggcu cagugcagcu gugcggaguu ggaaaguucc ccagccugcc uauccugucc     3180

ccggccuuga uggacgugcc guacagacug aacgaaauca cuaaggagaa ggagcagugu     3240

ugcgugucgu uggcggccgg gcugccccac uuuucaagcg ggauuuuccg gugcugggga     3300

agggacaccu ucaucgcgcu gcggggaauc cugcugauua ccggacgcua cguggaggcu     3360

cggaacauca uucucgcguu cgccggcacc cugcgccaug gacugauccc uaaucugcuu     3420

ggagagggca ucuacgcucg guacaacugc agagaugccg ugugguggug gcuccaaugc     3480

auccaggauu acugcaagau ggugccuaac ggucuggaca uucugaagug cccugugucc     3540

cgcauguacc ccaccgacga cuccgccccc cugccugccg gaacccucga ccagccucug     3600

uucgaaguca uccaagaggc caugcagaag cauaugcagg gcauucaguu ccgcgaacgg     3660

aacgcagggc cccagaucga ccggaacaug aaggaugaag gguucaacau caccgccgga     3720

guggaugaag agacuggauu ugucuacgga ggaaaccgcu uuaacugcgg gaccuggaug     3780

gacaagaugg gagagucaga cagggccaga aauagaggaa uccccgcgac cccgcgcgac     3840

ggauccgccg uggagauugu gggccuguca aagagcgccg uccgcuggcu gcuggaacuu     3900

agcaagaaga acaucuuccc uuaccacgaa gugaccguga aaagacaugg caaagccauc     3960

aaagucuccu acgacgagug gaaccgcaag auucaggaca acuucgaaaa gcuguuccac     4020

guguccgaag aucccuccga ucugaacgag aagcauccga accuggucca uaagcgggga     4080

aucuacaagg auagcuacgg ugccagcucg ccguggugug acuaccagcu gcggccaaau     4140

uucacgauug cgauggucgu cgccccugag uuguucacca cugagaaggc cuggaaagcc     4200

cuggaaauag ccgagaagaa auuacugggg ccacugggca ugaaaacucu cgacccugac     4260

gacauggugu acuguggaau cuacgacaac gcacuggaca acgauaacua caauuuggcc     4320

aagggauuca acuaccacca ggggcccgaa uggcuguggc cuaucggaua cuuccuucgg     4380

gcaaagcuuu acuucucccg ccugauggga ccugaaacua cugccaagac cauugugcuu     4440

gugaagaacg ugcucucacg gcacuacgug caccuggaga gauccccgug gaaggggcuc     4500

ccggagcuga ccaacgagaa cgcccaguac ugcccuuucu ccugcgaaac ccaagccugg     4560

uccaucgcca ccauacuuga aacucuguac gaccuguag                            4599


<210>  21
<211>  4599
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Codon-Optimized AGL Coding Sequence

<400>  21
augggacacu ccaagcagau ccgcauucuc cuccugaacg aaauggaaaa gcuggaaaag       60

accuuauuuc gccuugaaca aggauacgag cugcaguucc ggcuuggacc gacccuccaa      120

gggaaagcug ucaccgucua caccaacuac cccuucccgg gggagacuuu caacagagag      180

aaguucagau ccuuggacug ggaaaauccc acggaacggg aggacgacuc cgauaaguac      240

uguaaacuga accuccagca gucgggaucg uuccaguacu acuuccuaca agggaacgaa      300

aaguccggug gugguuacau cgugguggac ccgauccugc gcgugggggc cgacaaccac      360

gugcugccgc uggacugcgu gacucugcaa accuuccugg ccaagugccu cggcccguuc      420

gaugaauggg agucgagacu gcggguggcc aaggaaagcg gauacaauau gauucacuuu      480

acuccgcugc aaacccuggg gcugucgcgc uccugcuacu cgcucgcuaa ccagcuggaa      540

cugaauccgg auuuuagccg gccgaaccgg aaguauacgu ggaacgacgu cggucagcug      600

gucgagaagc ucaagaagga guggaacguc auuugcauca ccgacguggu cuacaaccac      660

accgcggcca auuccaagug gauccaggaa cacccggagu gcgccuauaa cuuggugaac      720

uccccucauu ugaaacccgc augggugcuc gaccgggccc uguggcgcuu uucaugcgac      780

guggcggaag ggaaguacaa ggaaaagggg auucccgccc ugaucgagaa cgaucaccac      840

augaacucaa uucgcaaaau caucugggag gauaucuucc cuaagcucaa gcugugggaa      900

uucuuccaag ucgacgucaa caaggccgug gaacaauuca gaaggcugcu gacccaagag      960

aaccgcagag ugaccaaguc ggacccgaac cagcaccuga cuauaaucca ggacccggaa     1020

uaccggaggu ucgguugcac cguggacaug aacauugcac ucaccaccuu caucccgcac     1080

gauaaggguc cggcggcgau ugaggagugc ugcaacuggu uccacaagcg gauggaggaa     1140

cugaacuccg agaagcaccg gcugauuaac uaccaccagg aacaggcugu gaauugccug     1200

cuggggaacg uguucuacga acggcucgcc ggccacggcc ccaagcuggg gcccgucacc     1260

cgcaagcacc cgcucgugac ucgauauuuc accuucccgu ucgaggaaau ugauuucucc     1320

auggaggaau caaugaucca ucugccgaac aaggccuguu ucuugauggc ccacaacggc     1380

ugggugaugg gagaugaccc gcugagaaau uucgccgagc cgggguccga gguguaccug     1440

aggagagaac ucaucugcug gggggauucc gugaaacugc gcuacgggaa caagcccgag     1500

gacugccccu accugugggc acauaugaag aaguacaccg aaaucaccgc caccuacuuc     1560

caaggggucc ggcuggauaa cugccauuca acuccgcucc auguggccga auacaugcug     1620

gacgccgcac ggaacuugca gcccaaccuc uacguggugg ccgaacucuu cacugggagc     1680

gaagaucucg auaacguguu cgugacccgg cucggaauuu cgagccugau ccgggaagcg     1740

augucugcuu acaacucgca cgaagaggga aggcuggugu acagauacgg gggggagccc     1800

gugggauccu ucgugcaacc gugccugagg ccgcuuaugc ccgcgaucgc ccacgcucug     1860

uucauggaca ucacccacga caacgaaugu ccgauugucc accggagugc cuacgaugcc     1920

cuuccgagca cuaccaucgu gucgauggcg ugcugugcgu ccgggucuac ccgcggcuac     1980

gacgaacucg ucccgcacca aaucagcgug guguccgaag aacgguuuua cacuaagugg     2040

aacccggagg ccuugcccuc gaacaccggg gaggucaacu uccagucggg aaucauugcc     2100

gcccgaugug ccaucucaaa guugcaccaa gaacucgggg caaagggguu cauccaagug     2160

uacguggacc aaguggacga ggauauugug gccgugacca ggcacucccc gucgauccac     2220

caguccgugg uggcagucuc aagaacugcc uuccggaacc ccaagaccuc cuuuuacucg     2280

aaggaagugc cccagaugug caucccgggc aaaaucgaag aagucgugcu ggaagccaga     2340

acuaucgagc ggaacaccaa gcccuaccgg aaggaugaga acagcaucaa cggcacgccc     2400

gacaucaccg ucgagaucag agagcacauc cagcugaacg aauccaagau ugucaagcag     2460

gccggcguag cgacuaaggg acccaacgaa uacauccagg agaucgaauu cgaaaaccug     2520

ucgccgggau ccgugauuau cuuccgggug ucccuggacc cgcacgccca aguggccgug     2580

ggaauccugc ggaaccaccu gacccaguuc uccccgcauu ucaaguccgg cucccuggcg     2640

guggacaaug cagacccgau ucucaagauc ccguucgccu ccuuggccuc ccgccugacc     2700

cucgccgaac ucaaccagau ccuguaccgc ugcgagucug aggaaaagga ggacggggga     2760

ggaugcuacg auauuccgaa cuggucugcc cuuaaauacg cgggacugca gggucugaug     2820

ucggugcucg ccgagaucag accgaagaac gaccuggggc acccguuuug caacaaccug     2880

agaucggggg auuggaugau cgacuacgug ucgaaccggc uuaucucucg cuccggcacc     2940

aucgccgagg ucgggaagug gcugcaggcc auguucuucu accugaagca aauuccgcgc     3000

uaccugaucc cgugcuacuu ugaugccauc cugaucggcg ccuacacgac cuugcuggac     3060

accgccugga agcagaugag cagcuucgug cagaacggcu ccacguucgu gaagcaucug     3120

ucccugggau ccgugcagcu uugcgguguc ggaaaguucc cuucgcugcc uauucugucc     3180

ccggcgcuga uggacgugcc guaccggcug aacgagauca cuaaggagaa ggaacaaugc     3240

ugcgugucac uggcggcggg acucccccac uucuccuccg ggauuuuccg guguugggga     3300

agagauaccu ucauugcccu gagggggaua cugcugauca ccggaagaua cguggaggcu     3360

agaaacauca uccucgccuu cgccggcacu cuccgccacg ggcugauccc caaccucuug     3420

ggcgaaggaa ucuacgcccg guauaacugc cgcgacgcgg ucugguggug gcuucagugc     3480

auccaggauu acugcaaaau ggugccgaau ggacuggaua uucugaagug ccccguuagc     3540

cgcauguacc ccaccgauga cuccgcaccc uugccggcgg gcaccuugga ccagccgcuc     3600

uuugaaguga uccaggaggc caugcagaag cacaugcagg guauccaguu cagagagcgg     3660

aacgcugggc cgcagauuga ccggaacaug aaggacgaag guuucaacau uacugccggg     3720

guggacgaag agacuggguu uguguacggg gggaaccgcu ucaacugugg gaccuggaug     3780

gauaagaugg gggagucgga ucgggcucgg aacaggggga uccccgcuac cccccgggac     3840

gggucggcug uggagauugu cgggcugagc aagagcgcag ugcgcuggcu gcuggagcuc     3900

agcaaaaaga acaucuuccc cuaccacgaa gucacuguga agagacacgg aaaggccauc     3960

aagguguccu acgaugagug gaacagaaag auccaagaca acuucgagaa gcuguuccau     4020

guguccgagg auccgagcga ucugaacgaa aagcauccga accucgugca caagcgcggg     4080

aucuacaagg acucguacgg cgcauccucg ccguggugcg acuaccagcu gcgccccaau     4140

uucaccauug ccaugguggu ggcgcccgag cuguucacua ccgagaaggc cuggaaggcc     4200

cuggagauug cugagaagaa gcugcuggga ccgcucggga ugaaaacuuu ggacccugac     4260

gacauggugu acuguggaau cuacgacaau gcgcucgaca acgacaacua caaucuugcg     4320

aagggauuca acuaccauca ggggcccgaa uggcuguggc cgaucgggua cuuccugcgc     4380

gccaagcugu acuucucccg gcugaugggg cccgagacaa ccgccaagac cauugugcuc     4440

gucaagaacg uucucucccg gcacuacgug caccucgaaa gauccccgug gaaggggcug     4500

cccgagcuca ccaacgagaa cgcacaguac ugcccguucu ccugugaaac ccaggccugg     4560

agcaucgcca ccauauugga aacucuguau gaccucuag                            4599


<210>  22
<211>  4599
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Codon-Optimized AGL Coding Sequence

<400>  22
augggacacu cgaaacagau cagaauccug uugcugaacg aaauggagaa gcuggaaaag       60

acccucuuuc ggcucgaaca gggcuacgag cugcaguucc gccugggucc gacucuacaa      120

ggaaaggcag ugacugugua caccaacuac ccauuucccg gagaaaccuu caaccgggag      180

aaguuccggu cccuggacug ggaaaaccca accgaacgag aggaugauuc cgacaaguac      240

ugcaagcuga accuccaaca guccggauca uuccaguacu acuuuuugca aggaaacgag      300

aaguccggag gaggcuacau cguggucgac ccgauucuga gagugggagc ugacaaucau      360

guccugccuc uggacugcgu aacccugcaa accuucuugg ccaaaugccu gggcccguuc      420

gaugaguggg aaagccgccu ccgggucgca aaggaaagcg gcuacaauau gauucacuuc      480

acuccucugc aaacccucgg ucugucccgg uccuguuauu cccuggcgaa ccagcuggag      540

cuuaaccccg acuucucgcg cccaaaccgg aaguacaccu ggaacgacgu cgggcagcuu      600

guggaaaagc ugaagaagga guggaacgug aucugcauca cugacguggu guacaaccac      660

accgcggcca acuccaagug gauccaagaa caucccgaau gcgcguacaa ccucgugaac      720

agcccgcauc ugaagccugc cugggugcug gauagggccc ucuggagauu cagcugcgac      780

guggccgagg ggaaguacaa agaaaaggga auucccgccc ugauugagaa cgaccaucac      840

augaacucaa uccgcaagau caucugggag gauaucuucc cuaagcuuaa guugugggag      900

uucuuccaag uggacgugaa caaggcagug gagcaguuca gaaggcugcu gacucaagaa      960

aacagacggg ucacuaaguc cgacccuaac cagcaccuua ccaucauuca agacccggag     1020

uaccgccggu uuggcugcac ugucgacaug aacaucgccc ugaccacuuu caucccgcau     1080

gacaagggcc cggcggcaau cgaggaaugc uguaacuggu uucauaagag gauggaggaa     1140

cugaauuccg agaagcaccg gcugauuaac uaccaccagg aacaggcagu gaauugccuc     1200

cugggaaacg uguucuacga acggcuggcu ggacacggac cgaagcuggg ucccgugacu     1260

cgcaagcauc cgcucgugac ucgcuacuuc accuucccgu uugaggagau ugacuuuucc     1320

auggaagaau ccaugaucca ccucccgaac aaggcuugcu uccugauggc gcacaacgga     1380

ugggucaugg gcgacgaccc acugcgcaac uucgcugagc cuggcagcga ggucuaccug     1440

agaagggaac ugauuugcug gggagacucc gucaagcugc gcuauggaaa caagcccgaa     1500

gauugccccu accugugggc ucacaugaag aaguacacug aaaucacugc cacguacuuc     1560

cagggagucc ggcuggacaa uugccacucc accccccucc auguggccga guacaugcuc     1620

gaugcagcga ggaaucugca gcccaaucug uacgugguug ccgaacuguu caccggcucc     1680

gaggaccucg acaacguguu cgugaccaga cuugggauuu ccagccugau ccgggaagcc     1740

augucggccu acaacuccca ugaagagggc cgccuggugu accgcuacgg cggagaaccc     1800

gugggaagcu ucgugcagcc uugccuccgg ccgcugaugc cugcgaucgc ccacgcccug     1860

uucauggaua uuacccacga caacgaaugc cccaucgugc aucgcucggc cuacgacgca     1920

cugccuucga ccaccaucgu guccauggcc ugcugcgccu ccgguagcac ccgcggauac     1980

gaugaacucg ugccgcacca gaucagcgug guguccgaag aaagauucua caccaagugg     2040

aacccugagg cacugccgag caacaccgga gaagugaacu uccagucggg uauuaucgcc     2100

gcucgcugug ccaucuccaa acuccaccaa gagcucggug ccaagggauu cauucaaguc     2160

uacguggauc aggucgacga agauauugug gccgugacca ggcacucacc uuccauccac     2220

caauccgucg ucgccguguc acggacugcc uuccggaacc ccaagacuuc guucuacucg     2280

aaagaggugc cacagaugug uauccccgga aagaucgaag aggucguccu ggaagcccgg     2340

accauugaga ggaacaccaa gccuuaccgg aaggacgaga acagcaucaa cgguaccccu     2400

gauauuacug uggagauccg cgaacacauc cagcucaacg aaucaaagau ugucaagcag     2460

gccggagugg ccaccaaggg acccaacgag uacauccagg agaucgaauu ugaaaaccuc     2520

uccccuggcu ccgugauuau cuuccgggug ucccuggacc cucacgccca aguggccguc     2580

ggcauccuca gaaaccaccu gacccaguuc ucaccccauu ucaaguccgg uucccuggcg     2640

guggacaacg ccgauccgau cuugaagauc cccuuugcau cccuggccuc ccgccugacu     2700

cucgcggaac ugaaccagau ccuguaccgc ugcgaaucag aggaaaagga ggacggcggc     2760

ggcuguuacg auaucccgaa uugguccgcu cugaaauaug cgggacuuca ggggcugaug     2820

agcgugcugg cggagauccg gccgaagaau gaccugggac acccauucug caacaacuug     2880

cggagcggag acuggaugau cgauuacguc agcaacagau ugaucucccg gagcggcacu     2940

aucgcggagg ucggaaagug gcuccaggcc auguucuucu accugaagca gaucccccga     3000

uaccucaucc cguguuacuu cgacgccauu cugaucgggg ccuacaccac ccugcuggac     3060

accgccugga agcagaugag cuccuuugug caaaacgggu ccaccuucgu gaagcaccuu     3120

ucacugggau cagugcagcu cugcggcgug ggaaaauucc ccucgcugcc cauucugagc     3180

ccggcccuca uggacguccc uuaccggcug aacgagauca ccaaggagaa ggagcagugc     3240

uguguuuccc uggcugccgg acuuccacac uucucguccg gcaucuuccg gugcuggggc     3300

cgggauaccu ucauugcccu gcggggcauc uuguugauca ccggucgcua cguggaggcu     3360

cggaacauua uucuggcauu cgccggcacu cugagacacg gucugauucc gaaucuuuug     3420

ggcgaaggaa ucuacgcccg cuacaacugu cgggacgccg ugugguggug gcuccagugc     3480

auucaggacu auugcaagau ggugccgaac ggccuggaca uccugaagug cccagugucg     3540

aggauguauc caaccgacga cagcgcgccu cugccggccg ggacccucga ccaaccccug     3600

uucgaaguca uucaagaggc uaugcagaag cacaugcagg guauucaguu ccgggagaga     3660

aacgcggggc cccagauuga uaggaacaug aaagacgagg gcuucaacau cacugccggc     3720

guggacgaag aaaccgguuu uguguacgga ggaaaccggu ucaacugcgg uaccuggaug     3780

gacaagaugg gagaguccga ucgcgcgcgc aacagaggga ucccggcaac cccgcgggac     3840

ggaucagcgg uggaaauugu gggacugagc aagagcgccg ugcgcuggcu ccuggaacug     3900

agcaaaaaga acaucuuccc cuaccacgaa gugaccguga agcggcacgg aaaggccauc     3960

aaagucucau acgaugaaug gaauaggaag auccaggaua acuucgagaa gcuguuucac     4020

guguccgagg aucccuccga ucugaacgaa aagcauccga aucucgugca caagcgcggc     4080

aucuacaagg acucguacgg agccuccucc ccuuggugcg auuaucagcu gcggccuaac     4140

uucaccauug ccauggucgu ggcuccggag cuguucacua cugagaaggc cuggaaggca     4200

cuugaaauug ccgagaagaa gcugcuuggg ccuuugggga ugaaaacccu ggauccggac     4260

gacauggugu acugcggaau cuacgacaac gcccuggaca acgacaacua caaucuggcg     4320

aagggcuuca auuaccacca gggcccggaa uggcuguggc cuauugggua cuuccugcgc     4380

gccaagcugu acuucucacg gcugauggga ccagagacua ccgccaagac uaucguccuc     4440

gugaagaacg ugcugucccg gcacuacgug caucuggaga ggagcccuug gaagggccuu     4500

ccugagcuga ccaacgaaaa cgcccaguac ugccccuucu ccugcgaaac ccaggcuugg     4560

uccauugcca cuauacugga aaccuuauau gaccuguag                            4599


<210>  23
<211>  4599
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Codon-Optimized AGL Coding Sequence

<400>  23
augggacacu caaagcagau ccggauccuc cugcugaacg aaauggaaaa gcucgaaaag       60

acucuguucc ggcuggaaca gggcuaugag cugcaguucc ggcucggacc gacgcugcaa      120

ggaaaggccg ugacugugua caccaacuac cccuucccgg gagaaacuuu uaacagagaa      180

aaguuuaggu cccuggacug ggagaacccg accgagcggg aagaugacuc cgauaaguac      240

ugcaagcuga accuccagca gucgggaucg uuccaguacu acuuccuuca aggaaaugag      300

aagucuggug gaggauacau cgugguggac cccauccuga gagugggagc cgacaaucac      360

guccugccgc uugacugcgu gacucugcaa accuuccugg cuaagugucu cgggccguuc      420

gacgaauggg aguccaggcu gcgcguggcu aaggagagcg gcuacaauau gauccacuuc      480

accccgcucc aaacucucgg acucucgcgc uccuguuacu cccucgccaa ccaacuggag      540

cugaacccgg acuucucccg cccgaaccgg aaguacaccu ggaacgacgu cggucagcuc      600

guggagaaau ugaagaagga guggaacgug aucugcauua cggacgucgu guacaaccau      660

acugcggcca acuccaagug gauucaagag cacccggaau gcgcuuacaa ccuugucaac      720

uccccgcacc ugaagccggc cugggugcug gacagagccc uguggcgguu cucgugcgac      780

guggcagagg gaaaguacaa ggagaagggc auccccgccc uuauugagaa ugaccaucac      840

augaacucca uccggaagau caucugggag gauaucuucc cgaagcucaa gcugugggaa      900

uucuuccaag uggacgugaa caaggccgug gaacaguucc ggagacuccu gacccaagaa      960

aaccggagag ugaccaagag cgacccgaac cagcaucuga cuaucauuca ggauccggag     1020

uaucggcggu uuggcugcac uguggacaug aacaucgccc ucaccaccuu caucccgcac     1080

gacaagggcc ccgccgcgau cgaggaaugc ugcaacuggu uccacaagcg cauggaggag     1140

cugaauuccg aaaagcaccg ccugaucaac uaccaucagg agcaggcagu gaacugucuc     1200

cugggaaacg uguuuuacga acggcuggcc ggacacggcc cgaagcuggg ucccgugacc     1260

cgcaagcauc cccucgugac gcgguacuuc accuucccgu ucgaggagau cgacuucagc     1320

auggaagagu ccaugaucca ucugccgaac aaggccugcu uccucauggc gcauaauggu     1380

ugggucaugg gagaugaucc ccuccgaaac uuugcggagc cggguucgga aguguaucug     1440

aggagggagc ucaucugcug gggagauagc gugaaacuga gauacgggaa caagccggaa     1500

gauuguccgu accugugggc acacaugaag aaguacaccg aaaucacugc cacuuacuuc     1560

caaggaguuc gccuggauaa cugccauuca accccucugc augucgccga guacaugcug     1620

gacgccgcuc gcaaccuuca gccgaaucuc uacguggucg ccgagcuguu caccgguucc     1680

gaagaucugg acaacguguu cgugacuaga cugggaauca gcagccugau ccgggaagcg     1740

augagcgccu acaacuccca cgaagagggc cggcucgugu auagauacgg cggagagccg     1800

gucgggagcu ucgugcaacc cugccugcgg ccgcugaugc ccgccauugc ccacgccuug     1860

uucauggaua ucacccacga caacgagugu ccgaucgugc accggagcgc guacgacgcg     1920

uuaccgucca ccacgauugu gucgauggcc ugcugcgccu ccggaucgac ccgcggcuac     1980

gaugagcugg ucccgcauca aaucagcguc gucagcgaag aacgguucua cacuaagugg     2040

aaccccgagg cgcuccccuc caacaccgga gaagugaacu uccaauccgg cauuaucgcu     2100

gcacgcugcg cgauuagcaa gcugcaucag gagcuuggcg cuaagggguu cauacagguc     2160

uacguggauc aggucgacga ggacauugug gccgugacuc gccacucacc guccauucac     2220

caaagcgugg uggcuguguc ccggaccgcu uuccggaauc ccaagaccuc auucuacucc     2280

aaggagguuc cgcagaugug uaucccggga aagauugagg aagugguccu agaggcucgc     2340

acuauugaac gcaacaccaa gccguacaga aaggacgaga auuccauuaa cgggaccccg     2400

gauauuaccg uagaaauuag agaacauauu cagcugaacg agucgaagau cgugaagcag     2460

gccggggugg cuaccaaggg cccgaacgaa uacauccagg agauugaguu cgaaaaccuc     2520

ucccccggcu cggugaucau cuuccgggug ucccucgauc cccacgccca aguggccgug     2580

ggaaucuuga gaaaccaccu gacucaguuc agcccgcauu ucaaguccgg aucacucgcc     2640

guggacaacg ccgacccgau ccuuaagauc cccuucgcau cacuggccag ccgccugacc     2700

cuugccgaac ugaaccaaau ccucuaucgg ugcgaauccg aggagaagga agaugggggu     2760

ggaugcuaug acauuccuaa cuggucugcc cugaaauacg caggccugca gggacugaug     2820

uccguccugg ccgaaauccg cccgaagaau gaccuggggc accccuuuug caacaaucug     2880

agguccggag auuggaugau ugauuacgug uccaaccgcc ugauuucgcg gagcggcacc     2940

aucgcggaag ugggaaagug gcugcaagcc auguuuuucu accugaaaca gaucccccgg     3000

uaccucaucc cgugcuauuu cgaugcgauu uugauuggcg cguacaccac ccuccucgac     3060

acugccugga agcaaaugag cuccuucgug caaaacgguu caaccuucgu caagcacuug     3120

ucgcuggggu cgguccaacu guguggaguc ggaaaguucc cgagccugcc cauccugucg     3180

ccugcccuga uggacgugcc cuaccggcug aacgagauca ccaaagaaaa ggagcagugc     3240

ugcguguccc uggcggccgg acucccccau uucucguccg ggaucuuuag auguugggga     3300

cgggauacuu ucauugcgcu gcgcggcauc uuguugauua ccggacgcua cguggaagcg     3360

cggaacauca uacucgccuu cgccggcacc cucagacacg gccugauccc gaaccuccug     3420

ggagaaggca ucuacgcacg auacaacugu cgggacgccg ucugguggug gcugcagugc     3480

auucaggacu acugcaagau ggugccgaac ggucuggaca uccugaagug ccccguguca     3540

aggauguacc cgaccgacga uagcgcaccg cugcccgcgg ggacccugga ucagccgcug     3600

uucgaaguga uccaagaagc caugcaaaag cacaugcagg gaauucaguu cagagaaagg     3660

aacgcaggcc cccagauuga ccggaacaug aaggacgagg guuucaacau caccgccggc     3720

gucgacgaag aaacgggguu uguguacggg ggcaaccgcu ucaacugcgg uacuuggaug     3780

gacaagaugg gggaaucaga ccgcgcccgc aaccgcggaa uuccggcgac cccgcgcgau     3840

ggauccgcag uggaaaucgu gggacugucc aagucggcug ugcgguggcu gcuggagcug     3900

uccaagaaga acaucuuccc guaccacgag gucaccguga agagacacgg gaaggccauc     3960

aagguguccu acgacgaaug gaaccggaaa auccaggaua acuucgaaaa acuguuucac     4020

guguccgagg acccgucuga ccugaacgaa aaacacccga acuuggugca uaagcgggga     4080

aucuacaagg acaguuacgg agccucaagc ccguggugcg acuaccagcu gcggcccaac     4140

uucacaaucg cgaugguggu ggcgcccgag cuuuucacca cggagaaagc cuggaaggca     4200

cuggagaucg cugaaaagaa gcugcucggu ccccucggca ugaaaacccu ggacccggac     4260

gauauggugu acugcggaau cuacgacaac gcccuggaca augauaacua caaccuggcc     4320

aagggauuca auuaccacca ggggccggaa uggcuguggc cgaucggcua cuuucugcgg     4380

gcuaagcucu acuucucgcg gcugauggga ccggaaacca cagccaagac cauuguccuc     4440

gucaagaacg ugcugucccg ccacuacgug caucuggagc ggucaccuug gaagggccug     4500

cccgagcuga ccaacgaaaa cgcccaguac ugccccuucu ccugugaaac ucaagccugg     4560

ucaaucgcca cuauucucga aacucuguac gaucuguag                            4599


<210>  24
<211>  4599
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Codon-Optimized AGL Coding Sequence

<400>  24
augggucaca gcaaacaaau ccggauccug cugcucaacg aaauggaaaa gcuggaaaag       60

acucuguuuc gccuggagca gggcuacgaa cuccaauucc ggcugggacc aacgcugcaa      120

gggaaggccg ucaccgugua caccaacuac cccuuucccg gagagacuuu uaaccgcgaa      180

aaguucagaa gccuggacug ggaaaacccc accgaacggg aagaugauuc ggacaaguac      240

ugcaagcuga accuccagca guccggcagc uuccaguacu acuuccucca agggaacgaa      300

aagagcggag gaggcuacau cgugguggau ccgauccuuc ggguuggagc ggacaaccau      360

gugcugccuc uggacugcgu gacucugcaa accuuccuag ccaagugccu cggcccguuc      420

gaugaguggg aaucccggcu gcgaguggcg aaggagucag guuacaacau gauccacuuc      480

acaccgcugc agacccuggg acucucccgg uccugcuacu cauuggccaa ccagcucgaa      540

cugaacccgg acuucucaag gccgaaccgc aaguacacuu ggaaugacgu gggacaguug      600

guggagaagc ugaagaaaga guggaacgug aucugcauua ccgacguggu guacaaccac      660

acugcggcga auucgaagug gauucaggaa cauccggaau gcgccuacaa cuuggugaac      720

ucaccucacc ugaagccugc cugggugcug gacagagccc uguggcgcuu uagcugugac      780

gucgcggagg ggaaguacaa ggaaaaggga auccccgccc ugaucgagaa cgaccaccau      840

augaauagca uucgcaagau caucugggag gacauuuucc cgaagcugaa gcugugggag      900

uucuuccaag ucgacgucaa caaggccguc gaacaguucc ggcgguugcu gacccaagaa      960

aaccggagag ugacgaaaag cgacccuaac cagcaccuga caaucauuca ggacccugaa     1020

uaccggagau ucggcuguac cgucgauaug aacaucgccc ugaccaccuu uauuccccac     1080

gauaagggcc cggcggccau cgaggagugu ugcaacuggu uccacaagag aauggaggaa     1140

cucaacuccg aaaaacaccg guugauuaau uaccaccagg agcaggcggu caacugccug     1200

cugggcaacg uguucuacga aaggcucgcu gggcacggcc cuaagcuggg accugucacu     1260

cggaaacacc cccuggugac ccgguacuuu acuuucccgu ucgaagagau cgacuucucc     1320

auggaggaaa gcaugaucca ccucccuaac aaggccugcu uccugauggc ccacaacgga     1380

ugggucaugg gcgacgaccc uuugcggaac uuugccgagc cgggcucaga gguguaccuu     1440

agacgcgaac ugaucugcug gggagacucc gugaagcugc gcuacgggaa caagcccgaa     1500

gauuguccuu accugugggc acacaugaag aaguacaccg aaaucacugc caccuacuuc     1560

caaggagugc gcuuggauaa cugucauagc acuccucugc acgucgccga guacaugcug     1620

gacgcagcca ggaaucucca gccuaaucug uacguggugg ccgaacuguu caccgggagc     1680

gaggaccugg acaacguguu cgugacccgg cugggcauca gcucccuuau ccgggaggcc     1740

auguccgcau acaacucgca cgaggagggu cgccuggugu accgcuacgg aggagagccg     1800

gucggaucau uuguccaacc augccuccgg ccccugaugc cagcgaucgc gcacgcucuc     1860

uucauggaca ucacccacga uaacgaaugc ccuaucgugc accggagcgc uuacgacgcc     1920

cucccuucga ccaccauugu guccauggcc ugcugcgccu ccgguuccac ucggggcuac     1980

gaugaacugg ugccacacca gauuuccgug gugucagagg agcgguucua caccaagugg     2040

aacccagagg cgcugccgag caacacuggg gaagugaacu uccaguccgg aaucauagcg     2100

gcuagaugug caauuuccaa gcuucaucag gagcugggcg ccaaaggauu cauccagguc     2160

uacguggacc aaguggauga ggacauugug gccgugacua gacauucacc gucaauccac     2220

caaucggucg uggcuguguc cagaaccgca uuccgcaacc ccaagacuuc cuucuacucc     2280

aaggaggucc cucagaugug caucccggga aagaucgagg agguggugcu ggaggccagg     2340

accaucgaaa gaaacacuaa gccuuaccgg aaagacgaaa acuccaucaa ugggacuccc     2400

gauauuaccg uggagauuag ggagcacauu cagcugaacg aaucaaagau ugugaaacag     2460

gccggggucg caacuaaagg gccuaaugag uacauccaag agaucgaguu cgaaaaccug     2520

ucgccggguu ccgugaucau uuuccgcgug uccuuggacc cucacgccca aguggccgug     2580

ggcauccuga ggaaccaccu gacccaguuc agcccacacu ucaaguccgg auccuuggcu     2640

guggacaacg ccgauccaau ccucaagauc ccuuuugcgu cgcuggccuc acggcuuacc     2700

cuggccgagc ugaaccagau ccuguaccgc ugcgagagcg aagaaaagga ggacggugga     2760

gguugcuacg acauuccaaa cugguccgcg cuuaaguacg ccggacucca gggucugaug     2820

uccgugcuug ccgagaucag accgaaaaac gaccuggggc accccuuuug caacaaccug     2880

agaagcggag acuggaugau cgacuaugug uccaaccggc ugauuucgag aagcgguacu     2940

auugccgagg ucggaaagug gcuccaagca auguuuuucu accugaagca aauuccccgc     3000

uaccugaucc cgugcuacuu ugacgccauu cugaucggug cauacacuac ccugcuggac     3060

accgcgugga agcagauguc cagcuucgug cagaauggcu ccaccuucgu caagcaucug     3120

ucccucggaa gcgugcagcu gugcggagug ggaaaguuuc cgucgcugcc aauccugucc     3180

cccgcgcuga uggauguccc guaccggcug aacgaaauca cgaaggaaaa agaacagugc     3240

ugcguguccc uugccgccgg acugccgcac uucuccuccg gcauuuuccg gugcugggga     3300

cgggauaccu ucaucgcgcu gagagguauu cugcugauua ccggcagaua uguggaagcc     3360

cgcaacauca uccuggccuu ugccggcacu cugcggcacg ggcucauccc uaaccucuug     3420

ggagaaggca ucuacgcgcg cuacaacugc cgggaugcug ugugguggug gcugcagugc     3480

auccaggacu acuguaaaau ggugcccaau ggccuugaca uccucaagug cccagugucc     3540

cggauguacc cgaccgauga cuccgcgccc cugcccgccg gcacccuuga ucaaccucug     3600

uucgaaguca uccaagaggc caugcagaag cacaugcagg gaauccaguu cagggaaaga     3660

aacgccgggc cucagaucga ccggaacaug aaggacgagg gauucaacau uaccgccgga     3720

guggacgagg aaacuggcuu cguguacggu ggaaaccgcu ucaacugcgg caccuggaug     3780

gauaagaugg gcgaauccga ucgcgcccgc aaccggggaa ucccagcaac uccuagggac     3840

ggaagcgcag ucgagaucgu ggggcugucc aaguccgccg ugcgguggcu cuuagaacug     3900

uccaagaaga auauuuuccc cuaccacgag gucaccguga agcgccaugg aaaggccauc     3960

aaaguguccu augacgaaug gaaccgcaag auccaggaca acuucgaaaa guuguuccac     4020

guguccgagg accccagcga ucugaacgaa aagcacccca accucgugca caagaggggc     4080

aucuacaagg acuccuacgg agcuagcucc ccuuggugcg auuaccaacu gcggccuaau     4140

uucaccaucg ccauggucgu cgcacccgaa cucuucacca ccgagaaggc cuggaaggcu     4200

cuggaaaucg ccgaaaagaa gcuucugggc ccgcugggca ugaaaacucu cgauccugac     4260

gauauggucu acuguggcau cuacgacaac gcccuugaca acgacaacua caaccuggcc     4320

aagggcuuua acuaccacca gggcccagag uggcucuggc ccaucggaua uuuccugcgg     4380

gccaaacugu acuucucgcg guugaugggu ccggaaacca cagcuaagac caucgugcuc     4440

gugaagaaug ugcugucgcg gcacuauguc caucuggagc gcucccccug gaagggacuc     4500

ccugagcuga cuaaugagaa cgcccaguac ugcccuuucu ccugcgaaac ccaggccugg     4560

agcaucgcua ccauucucga aacgcucuac gaucuguag                            4599


<210>  25
<211>  4599
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Codon-Optimized AGL Coding Sequence

<400>  25
augggacauu cuaaacagau ucggauccuc cugcucaacg aaauggagaa gcucgaaaag       60

acccuguucc ggcucgaaca gggauacgaa cugcaauucc ggcugggucc caccuuacaa      120

ggaaaggccg ugacugucua caccaacuac ccguuccccg gcgaaaccuu caauagggag      180

aaguuccggu cccucgauug ggagaacccu acagagcgcg aagaugauuc agacaaguau      240

ugcaagcuga auuugcagca gagcggcuca uuccaauacu acuuccugca aggaaacgaa      300

aagucgggcg gcggcuacau cgugguggac ccuauucuga gagugggcgc cgacaaccau      360

guccugccgc uggacugcgu cacccugcaa acuuuccugg ccaagugccu ggguccuuuc      420

gaugaguggg aaucgagacu ucgcguggca aaggaaucgg guuauaauau gauucacuuc      480

accccgcugc aaacccuggg ccugucgcgg ucuugcuacu cacuggccaa ccagcuggaa      540

cugaacccag auuucucacg ccccaaccgg aaguacaccu ggaacgaugu gggccagcuu      600

guggaaaagc ucaaaaagga guggaacgug aucugcauua cugacguggu guacaaccau      660

acugcugcua auuccaagug gauccaggaa cauccugagu gugcuuacaa ccuggucaac      720

uccccacacc ugaagcccgc cugggugcug gaucgggcuc ucuggcgguu cuccugcgau      780

gucgccgaag gaaaguacaa ggagaagggg aucccugcgc ugaucgaaaa cgaccaucac      840

augaauucca ucaggaaaau caucugggag gacaucuucc cuaagcucaa gcugugggag      900

uucuuucaag ucgacgugaa caaggccgug gagcaguuca gacggcugcu gacacaagag      960

aaccgccgcg ucaccaagag cgacccgaau cagcaccuga cgauuaucca ggacccugag     1020

uacagaagau ucggcugcac cguggauaug aacauugcuc ugaccaccuu caucccccac     1080

gauaaggguc ccgcagccau ugaggagugc ugcaacuggu uccacaagag gauggaagaa     1140

cugaauuccg agaagcaccg gcugaucaau uaucaccaag aacaagccgu gaacugccuu     1200

cugggaaacg ucuuuuacga gcgccuggcg ggacaugggc caaagcucgg gcccgugacc     1260

agaaagcacc cacuggucac ccgcuacuuc accuucccgu ucgaggaaau cgacuucagc     1320

auggaagagu cgaugaucca cuugccgaac aaggccugcu uccucauggc ccauaacggu     1380

ugggucaugg gcgaugaccc ucuucgcaac uucgcggagc ccgguucuga agucuaucuu     1440

cggcgggaac ugauuugcug gggagacucc gucaagcugc gcuacggaaa caagcccgag     1500

gauugcccgu acuugugggc ccauaugaag aaguacacug agaucacugc cacuuacuuc     1560

caaggagugc gccucgacaa uugucacagc acuccgcugc acguggcgga guacaugcug     1620

gacgccgcuc gcaacuugca gccuaaucug uaugucgugg ccgaguuguu caccggcucg     1680

gaagaucugg acaacguguu cgucacucgc cugggaaucu ccucccugau ccgggaagcg     1740

augagcgccu acaacuccca cgaagagggg cgguuggugu accgcuacgg cggagagccu     1800

gucggaaguu ucgugcagcc cugucugagg ccccugaugc ccgcuaucgc ccaugcgcug     1860

uuuauggaca ucacccacga caacgaaugc ccuauugugc accgcuccgc cuaugaugcc     1920

cugcccucca ccacuauugu cagcauggcc ugcugcgccu cgggguccac ccggggauac     1980

gacgaacugg ugccccacca aauuuccgug guguccgagg aacgguucua caccaagugg     2040

aacccugaag cgcugccauc gaacacugga gaagugaacu uucagucggg aauuaucgca     2100

gcccgaugcg ccaucagcaa gcugcaccag gaacucggcg caaaggguuu uauccaaguc     2160

uacguggacc aggucgacga ggacauuguc gccgugaccc ggcacucccc auccauccac     2220

cagucugugg uggcuguguc aaggacggcu uuccggaacc caaagaccag cuucuacagc     2280

aaggaagugc cucagaugug caucccgggg aagaucgaag aaguggugcu ggaggccaga     2340

accaucgaaa gaaacaccaa gcccuaucgg aaggacgaga acucgaucaa cgguacuccg     2400

gacauuaccg ucgagauacg cgagcacauu cagcugaacg aguccaaaau cgugaagcag     2460

gccggggugg ccacgaaggg ucccaacgag uacauucagg agaucgaguu cgagaaccug     2520

agccccgggu ccgugaucau cuuccgcgug ucccuggacc cccacgccca aguggccgug     2580

ggcauccugc ggaaccaucu gacccaguuc uccccgcacu ucaagagcgg cucgcucgcc     2640

guggacaacg cggacccgau ccucaagauc ccuuucgcau cgcuggccuc ccgccugacc     2700

cuggccgaac ugaaucagau cuuguaccga ugcgaaucag aagagaagga ggacgggggg     2760

ggcugcuacg auauccccaa cuggagcgcg uugaaguacg caggauugca gggauugaug     2820

uccguccucg cugaaauccg cccgaagaac gaccugggac acccguuuug caacaaccug     2880

agaucagggg auuggaugau cgauuacgug ucgaacagac ugaucucgcg cagcggcacu     2940

auugccgaag uggggaagug gcuccaggcc auguucuucu accugaagca gaucccucgg     3000

uacuugaucc cuuguuacuu cgacgccauc cugaucggag ccuacaccac ccugcuugac     3060

acugcaugga agcagauguc cagcuucgug caaaacggaa gcaccuucgu gaagcaccug     3120

ucccugggau ccgugcagcu cugcggcgug ggaaaguuuc cgucccuccc cauccugagc     3180

ccugcccuua uggacgugcc guacaggcug aacgaaauua ccaaagagaa ggagcaaugc     3240

uguguguccu uggcggccgg auugccgcau uucuccuccg ggauuuuccg gugcugggga     3300

cgggacaccu uuaucgcacu gagggguauu cuccugauca ccggucgcua cguggaggcu     3360

cgcaacauua uucuggccuu cgcgggcacg cuuagacaug gauugauccc uaaccuucug     3420

ggagaaggga ucuacgcgcg guacaacugc cgcgaugccg ugugguggug gcugcagugc     3480

auccaggacu acugcaaaau ggugccgaau ggucuggaua uccugaagug uccgguuucg     3540

cggauguacc cuaccgacga cagcgccccu cucccggccg gcacucucga ccagccccua     3600

uuugaaguaa uccaggaggc caugcaaaag cacaugcagg gcauacaguu cagagagagg     3660

aacgccggac cgcagauuga ccggaacaug aaggacgagg gauucaacau uaccgcggga     3720

guggaugagg aaacugguuu cguguacggc ggaaaccggu uuaacugcgg cacuuggaug     3780

gacaagaugg gagaauccga ccgcgcccga aaccgcggaa uucccgccac uccccgcgac     3840

ggcuccgccg uggaaauugu gggacuguca aaguccgcag uccgcuggcu gcuggaacuc     3900

ucaaagaaga acaucuuccc guaccacgag gucaccguga agcggcacgg caaagcgauc     3960

aaagugucgu acgacgagug gaaccggaag auucaggaua acuucgagaa gcuguuucac     4020

guguccgaag auccaagcga ccugaacgag aagcauccca acuuggugca caagcgcggc     4080

aucuacaagg auuccuacgg agccagcagc ccguggugcg acuaccaacu ccgccccaac     4140

uucaccaucg ccaugguggu ggcgccggag cuguucacga cggagaaagc uuggaaggcu     4200

cucgaaaucg cggagaagaa gcugcugggu ccucugggga ugaaaacccu ggacccggac     4260

gauauggugu acugugggau cuacgacaac gcccuggaca acgacaacua caaccucgcc     4320

aagggguuca acuaccacca gggacccgaa uggcucuggc caaucggaua cuuccugaga     4380

gcgaagcuuu acuucucgcg gcugaugggu ccugaaacca cggccaagac caucgugcuc     4440

gugaaaaaug ugcugucaag gcacuacgug caucuggaga ggucgccaug gaagggucug     4500

ccggaacuga ccaacgaaaa cgcacaguac ugccccuuuu cgugcgagac ucaggccugg     4560

uccaucgcca ccauucucga aacucucuac gaccuguag                            4599


<210>  26
<211>  4599
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Codon-Optimized AGL Coding Sequence

<400>  26
augggacacu cgaaacagau cagaauccug uugcucaacg aaauggagaa gcuggaaaag       60

acccucuuuc ggcucgaaca gggcuacgag cugcaguucc gccugggucc gacacuacaa      120

ggaaaggcag ucacugugua caccaacuac ccauuucccg gagaaaccuu caaccgggag      180

aaguuccggu cccuggacug ggaaaaccca accgaacgag aggaugacuc cgacaaguac      240

ugcaagcuga accuccaaca guccggauca uuccaguacu acuuucugca agggaacgag      300

aaguccggag gcggcuacau cguggucgac ccaauacuua gagugggagc cgacaaucau      360

guccugccuc uggacugcgu gacccugcaa accuucuugg cgaaaugucu gggcccguuc      420

gaugaguggg aaagccgccu cagagucgca aaggaguccg gauacaacau gauucacuuc      480

acuccgcugc aaacccucgg ucugucccgg ucgugcuauu cucuggcgaa ccagcuggag      540

cuuaaccccg acuucucgcg cccaaaccgg aaguacaccu ggaacgacgu cgggcagcuu      600

guggaaaagc ugaagaagga guggaacgug aucugcauca cugacguggu guacaaccau      660

acggccgcca acucgaagug gauccaagag caucccgagu gcgcguacaa ccucgugaau      720

agcccgcauc ugaagccugc uugggugcug gauagagccc ucuggagauu cagcugcgac      780

guggccgagg ggaaguacaa agaaaaggga auuccggccu ugauugagaa cgaccaucac      840

augaacucaa uccgcaagau caucugggag gauaucuucc cuaagcuuaa guugugggag      900

uucuuccaag uggacguaaa caaggcagug gagcaguuca gaagguugcu gacucaagaa      960

aacagacggg ucacuaaguc cgauccuaac cagcaccuua ccaucauuca agacccugag     1020

uaccgccggu uuggcugcac cgucgacaug aacaucgccc ugaccacuuu caucccgcau     1080

gacaagggcc cggcggcaau cgaggaaugc uguaacuggu uucauaagag gauggaggaa     1140

cugaauuccg agaagcaccg gcugauuaac uaccaccagg aacaggcagu caacugccuc     1200

cugggcaacg uguucuacga acggcuggcu ggacacggac cgaagcuggg ucccgugacu     1260

cgcaagcauc cgcucgugac ucgcuacuuc accuucccgu uugaggagau ugacuucucc     1320

auggaagaau ccaugaucca ccucccgaac aaggcuugcu uccugauggc gcacaacgga     1380

ugggucaugg gcgacgaccc acugcgcaau uucgcugagc cuggcucgga ggucuaccug     1440

agaagggaau ugauuugcug gggagacucc gugaagcugc gcuauggcaa caagccugaa     1500

gauugccccu accugugggc ucacaugaag aaguacacgg aaaucacugc cacguacuuc     1560

cagggagucc ggcuggacaa uugccacucg accccgcucc auguggccga guacaugcug     1620

gaugcagcga ggaaucugca gcccaaucug uacgugguug cagaacuguu cacuggcucc     1680

gaggaccucg acaacguguu cgugaccaga cuggggauuu ccucacugau ccgggaagcc     1740

augucggccu acaacuccca ugaagagggc cgccuggugu accgcuaugg gggagaaccc     1800

gugggaagcu ucgugcagcc uugccuccgg ccgcugaugc cugcgaucgc ccacgcccug     1860

uucauggaua ucacucacga caacgaaugc cccauugugc aucgcucggc cuacgacgca     1920

cugccuucga ccacuaucgu guccauggcc ugcugcgccu ccgggagcac ccgcggauac     1980

gaugaacucg ugccgcacca gaucagcgug guguccgaag aacgguucua caccaagugg     2040

aaccccgaag cccugccuag caauaccggg gaagugaacu uccaguccgg uauuaucgcc     2100

gcucgcugcg ccaucuccaa acuccaccaa gagcucggug ccaagggauu cauucaaguc     2160

uacguggauc aggucgacga agauauugug gccgugacca ggcacucacc uuccauccac     2220

caauccgucg ucgccguguc ccggacugcg uuucggaacc ccaagacuuc guucuacucg     2280

aaagaagugc cacagaugug uaucccggga aaaaucgagg aggucgugcu cgaagcccgg     2340

accauugaga ggaacaccaa gccuuaccgg aaagacgaga acucuaucaa cgguaccccu     2400

gauauuacug uggagauccg cgaacacauc cagcugaacg aaucaaagau cgucaagcag     2460

gcuggagugg ccaccaaggg acccaacgag uacauccagg agaucgaauu ugaaaaccuc     2520

uccccuggcu ccgugauuau cuuccgggug ucccuggacc cucacgccca aguggccgug     2580

ggaauucuca gaaaccaccu gacccaguuc ucaccacacu uuaaguccgg uucccuggcg     2640

guggacaacg ccgauccgau cuugaagauc cccuucgcau cgcucgccuc ccgccugacu     2700

cucgcggaac ugaaccagau ccuguaccgc ugugaauccg aggaaaagga ggacggcggc     2760

ggcuguuacg auauccccaa uuggucggcu uugaaauacg cgggacuuca ggggcugaug     2820

ucugugcugg cggaaauccg gccgaagaac gaccugggac acccauucug caacaacuug     2880

cggagcggag acuggaugau cgauuacguc agcaacagau ugaucagccg gagcggcacu     2940

aucgccgagg ucggaaagug gcuccaggcc auguucuucu accugaagca gaucccccga     3000

uaccucaucc ccuguuacuu cgacgccauu cugaucgggg ccuacaccac ccugcuggac     3060

accgccugga agcagaugag caguuuugug caaaacgggu ccaccuucgu gaagcaccuu     3120

ucacugggcu cagugcagcu cugcggcgug ggaaaguucc ccucgcugcc cauucugagc     3180

cccgcccuga uggacguccc uuaccggcug aacgagauca ccaaggagaa ggagcagugc     3240

uguguuuccc uggcugccgg gcugccacac uucucguccg gcaucuuccg guguuggggc     3300

cgggauaccu ucauugcccu gcggggaauc cugcuuauca ccggucgcua cguggaggcu     3360

cggaacauua uucucgcguu cgccggcacc cugagacacg gucugauucc gaaucuguug     3420

ggcgaaggaa ucuacgccag auacaacugu cgggacgccg ugugguggug gcuccagugc     3480

auucaggacu auugcaagau ggugccgaac ggccuggaca uccugaagug cccagugucg     3540

aggauguauc caacugacga cagcgcaccu cugccggccg ggacccucga ccaaccccug     3600

uucgaaguca uucaagaggc uaugcagaag cacaugcagg guauucaguu ccgggagcgg     3660

aacgcggggc cccagauuga uaggaacaug aaagacgagg gcuucaacau cacugccggc     3720

guggacgaag aaaccgguuu uguguacgga ggaaaccgcu ucaacugcgg uaccuggaug     3780

gacaagaugg gagaauccga ucgcgcgcgc aacagaggga ucccggcaac cccucgggac     3840

ggauccgcgg uggaaauugu gggacugagc aagagcgccg ugcgguggcu ccuggaacug     3900

uccaaaaaga acaucuuccc cuaccacgaa gugaccguga agagacacgg aaaggccauc     3960

aaagucucau acgaugaaug gaacaggaag auccaggaua acuucgagaa gcuguuucac     4020

guguccgagg aucccuccga ucugaacgag aagcauccga aucuggugca caagcgcggg     4080

aucuacaagg acucguacgg agcguccucc ccuuggugcg acuaucagcu gcggccuaac     4140

uucaccauug ccauggucgu ggccccggag cuguucacaa cugagaaggc cuggaaggcc     4200

cuugaaauug ccgagaagaa gcugcugggg ccuuugggga ugaaaacccu ggauccggac     4260

gacauggugu acugcggaau cuacgacaac gcccuggaca acgauaacua caaucucgcg     4320

aagggcuuca auuaccacca aggccccgaa uggcucuggc cuauugggua cuuccugcgc     4380

gccaagcugu acuucucacg gcugauggga ccagagacua ccgccaagac uaucguccuc     4440

gugaagaacg ugcugucccg gcacuacgug caucuggaga ggagcccuug gaagggacuu     4500

ccugagcuga cgaacgaaaa cgcgcaguac ugccccuucu ccugcgaaac ccaggcuugg     4560

uccauugcca cuauacugga aaccuuauau gaccuguag                            4599


<210>  27
<211>  4599
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Codon-Optimized AGL Coding Sequence

<400>  27
augggacacu cgaaacagau ccggauccug uugcugaacg aaauggagaa gcuugaaaag       60

acccuguuuc ggcuggagca gggcuacgag cugcaguucc gccugggucc gacacuacaa      120

ggaaaggccg ugacugugua caccaacuac ccauuucccg gagaaacuuu caaccgggag      180

aaguuccggu cccuggacug ggaaaaccca accgaacgag aggacgacuc ggacaaguac      240

ugcaagcuga accuccaaca guccggauca uuccaguacu acuuucugca agggaacgag      300

aaguccggag gcggcuacau cguggucgac ccgauacuua gagugggcgc cgacaaucau      360

guccugccuc uggauugcgu gacccugcaa accuucuugg ccaaaugucu gggcccguuc      420

gaugaguggg aaagccgccu cagagucgca aaggaguccg gauacaacau gauucauuuc      480

accccgcugc aaacccuggg ucugucccgg ucgugcuauu cucuggcgaa ccagcuggag      540

cuuaaccccg acuucucgcg cccaaaccgg aaguacaccu ggaacgacgu cgggcagcuu      600

guggaaaagc ugaagaagga guggaacgug aucugcauca cugacguggu guacaaccau      660

acggccgcca acucgaagug gauccaggag caucccgagu gcgcauacaa ccucgugaac      720

agcccgcacc uuaagccugc uugggugcug gacagagccc ucuggagauu caguugcgac      780

guggccgagg ggaaguacaa ggaaaaggga auuccggccu ugaucgagaa cgaccaucac      840

augaacucaa ucaggaagau caucugggag gacaucuucc cuaagcuuaa guugugggag      900

uucuuccaag uggacguaaa caaggcagug gagcaguuca gaagguugcu gacccaagaa      960

aacagacgcg ucacuaaguc cgauccuaac caacaccuua ccaucauuca agacccugaa     1020

uaccgccggu uuggcugcac cgucgauaug aacaucgccc ugaccacuuu caucccgcau     1080

gacaagggcc cggcggcaau cgaggaaugc uguaacuggu uucauaagag aauggaagaa     1140

cugaauuccg agaagcaccg gcugauuaac uaccaccagg aacaggcagu gaacugccug     1200

cugggcaaug uguucuacga acggcuggcu ggacacggac cgaagcuggg ucccgugacu     1260

aggaagcauc cgcucgugac ucgcuacuuc accuucccgu uugaggagau ugacuucucg     1320

auggaagaau ccaugaucca ucugccuaac aaggcuugcu uccugauggc gcacaacgga     1380

ugggucaugg gcgacgaccc ccugcgcaac uucgccgagc cuggcucgga ggucuaccug     1440

agaagggaac uuaucuguug gggagacucc gucaagcugc gcuacggaaa caagcccgaa     1500

gauugccccu accugugggc ucacaugaag aaguacacgg aaaucacugc aacguacuuc     1560

cagggagucc ggcuggacaa uugccacucc accccccuuc auguggccga guacaugcuc     1620

gaugcagcga ggaaucugca gccgaaucug uacgugguug ccgaacuguu cacuggcucc     1680

gaggacuugg acaacguguu cgugaccaga cuggggaucu ccucccugau ccgggaagcc     1740

augucggccu acaacuccca ugaagagggc cgccuggugu accgcuacgg gggagaaccc     1800

gugggaagcu ucgugcaacc uugccugcgg ccgcugaugc cugcgaucgc ccacgcccug     1860

uucauggaca ucacucacga uaacgaaugc ccgauugugc aucgcucggc cuacgacgca     1920

cugccgagca ccacuaucgu guccauggcc ugcugcgccu ccgggagcac ucgcggauac     1980

gaugaacucg ugccgcacca gaucagcgug guguccgaag aacgcuucua uaccaagugg     2040

aaccccgaag cgcugccauc gaauacuggc gaagugaacu uccaguccgg uauuaucgcc     2100

gcucgcugug ccaucagcaa acugcaccaa gagcuuggug ccaagggauu cauucaaguc     2160

uacguggauc aggucgacga agauauugug gccgugacca ggcacucacc uuccauccac     2220

caaucagucg uggccguguc ccggaccgcg uuccggaacc ccaagaccag cuucuacucg     2280

aaagaagugc cucagaugug uaucccggga aaaaucgaag aggucgugcu ggaagcccgg     2340

accauugaga ggaacaccaa gccuuaccgg aaagacgaga acucuaucaa cgguaccccu     2400

gauauuacug uggagauccg cgaacacauc cagcugaacg aaucaaagau cgucaagcag     2460

gcuggagugg ccaccaaggg acccaacgag uacauccagg agaucgaauu ugaaaaccuc     2520

uccccuggcu ccgugauuau cuuucgggug ucccuggacc cucacgccca aguggccgug     2580

ggaauucuca gaaaccaccu gacccaguuc ucaccccacu ucaaguccgg uucccuggcg     2640

guggauaacg ccgacccgau uuugaagauc cccuucgccu cgcuggccuc ccgccugacu     2700

cucgcggaac ugaaccagau ccuguaccgc ugugaaucag aggaaaaaga ggacggcggc     2760

ggcuguuacg auauucccaa uuggucggcu uugaaauacg cgggacuuca ggggcugaug     2820

ucugugcugg cggaaauccg gccgaagaac gaccugggac acccauucug caacaacuug     2880

cgguccggag acuggaugau cgauuacguc agcaacagau ugaucagccg gagcggcacu     2940

aucgcugagg ucggaaagug gcugcaggcc auguucuucu aucugaagca gaucccccga     3000

uaccucaucc ccuguuacuu cgacgccauu cugaucgggg ccuacaccac ccugcuggac     3060

accgccugga agcagaugag caguuuugug caaaacgggu ccaccuucgu gaagcaccuu     3120

ucacugggcu cagugcagcu cugcggcgug ggaaaguucc ccucucugcc cauucugagc     3180

ccggcccuga uggacguccc uuaccggcug aacgagauca ccaaggagaa ggagcagugc     3240

ugcguuuccc uggcugccgg gcugccacac uucucguccg gcaucuuccg gugcuggggc     3300

cgggauaccu ucaucgcccu gcgggguauc cugcuuauca ccggucgcua cguggaggcu     3360

cggaacauua uucuggcguu cgccggcacc cuuagacacg gacugauucc gaaccuuuug     3420

ggcgaaggaa ucuacgccag auacaacugu cgggacgccg ugugguggug gcuucagugc     3480

auucaggacu auugcaagau ggugccgaac ggccuggaca uccugaagug cccagugucg     3540

aggauguauc caaccgacga cagcgcaccu cugccggccg ggacccucga ccaaccccug     3600

uucgaaguca uucaggaggc uaugcagaag cacaugcagg guauucaguu ccgggagcgg     3660

aacgcggggc cgcagauuga uaggaacaug aaagacgagg gcuucaacau cacugccggc     3720

guggacgaag aaaccgguuu uguguacgga ggaaacagau ucaacugcgg uaccuggaug     3780

gacaagaugg gagaguccga ucgcgcgcgc aacagaggga ucccggcaac cccgcgggac     3840

ggauccgcgg uggaaauugu gggacugagc aagagcgccg ugcgguggcu gcuggaacug     3900

agcaaaaaga acaucuuccc cuaccacgaa gugaccguga agcggcacgg aaaggccauc     3960

aaagucucau acgaugaaug gaauaggaag auccaggaua acuucgagaa gcuguuucac     4020

guguccgagg aucccuccga ucugaacgaa aagcacccga aucucgugca caagcgcggg     4080

aucuauaagg acucguacgg agcguccucc ccuuggugcg acuaucagcu gcggccuaac     4140

uucaccauug ccauggucgu ggccccggag cuguucacaa cugagaaggc cuggaaggcc     4200

cuugaaauug ccgagaagaa gcugcugggg ccuuugggga ugaaaacccu ggauccggac     4260

gacauggugu acugcggaau cuacgacaac gcccuggaca acgauaacua caaucuggcc     4320

aagggcuuca auuaccacca gggcccggaa uggcuguggc ccauugggua cuuccugcgc     4380

gccaagcugu acuucucacg gcugauggga ccagagacua ccgccaagac uaucguccuc     4440

gugaagaacg ugcugucccg gcacuacgug caucuggaga ggagcccuug gaagggacuu     4500

ccugaacuga cuaacgagaa cgcgcaguac ugccccuucu ccugcgaaac ccaggcuugg     4560

uccauugcca ccauacugga aacccuuuau gaccuguag                            4599


<210>  28
<211>  4599
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Codon-Optimized AGL Coding Sequence

<400>  28
augggacacu cgaaacagau uagaauccug uugcucaacg aaauggagaa gcuggaaaag       60

acccucuuuc ggcuggagca gggcuacgag cuccaguucc gccugggucc gacacuacaa      120

gggaaggcag ugaccgugua caccaacuac ccauuucccg gagaaaccuu caaccgggag      180

aaguuccggu cccuggacug ggaaaaccca accgaacgag aggaugacag cgacaaguac      240

ugcaagcuga accuccaaca gucgggaucg uuccaguacu acuuucugca agggaacgag      300

aaguccggag gaggcuacau cguggucgac ccgauacuua gagugggagc cgacaaccau      360

guccugccuc uggacugcgu gacccugcaa accuucuugg ccaaaugucu gggcccguuc      420

gaugaguggg aaagccgccu cagaguggcc aaggaguccg gguacaacau gauucacuuc      480

acuccgcugc aaacccucgg ucugucccgg ucgugcuauu cucuggcgaa ccagcuggag      540

cugaaccccg acuucucccg cccaaaccgg aaguacaccu ggaacgacgu cgggcagcuu      600

guggaaaagc ugaagaagga guggaacgug aucugcauua cugacguggu guacaaccac      660

accgccgcca acucgaagug gauccaagaa caucccgagu gcgcguacaa ccucgugaac      720

agcccgcauc ugaagccggc uugggugcuc gauagagccc ucuggagauu cuccugugac      780

gucgccgagg ggaaguacaa agagaagggu auuccggccc ucauugagaa cgaccaucac      840

augaacucaa uccggaagau caucugggag gauaucuucc cuaagcuuaa guugugggag      900

uucuuccaag uggacguaaa caaggccgug gaacaguuca gaaggcugcu gacucaagaa      960

aaccgccgcg ucacuaaguc cgauccuaac cagcaucuua ccaucaucca agacccugag     1020

uaucgccggu uugggugcac cgucgacaug aacaucgcac ugaccacuuu caucccgcau     1080

gacaaggggc cggcggccau cgaggaaugc uguaacuggu uucauaagag gauggaggaa     1140

cugaauuccg agaagcaccg gcugauuaac uaccaccagg aacaggcagu gaauugccuc     1200

cuggggaacg uguucuacga aaggcuggcu ggacacggac cgaagcuggg gcccgugacu     1260

cgcaagcauc cgcucgugac ucgcuacuuc accuucccgu uugaggagau ugacuucuca     1320

auggaagaau ccaugaucca ccucccgaac aaggcuugcu ucuugauggc gcacaaugga     1380

ugggucaugg gcgacgaccc acugcgcaac uucgcugagc cuggcucgga ggucuaccug     1440

agaagggaau ugauuugcug gggggacucc gucaagcugc gcuauggaaa caagccggaa     1500

gauugccccu accugugggc ucacaugaag aaguacacgg aaauuacugc cacguacuuc     1560

cagggcgucc ggcuggacaa cugccacucc acuccccucc auguggccga guacaugcuc     1620

gacgcagcga ggaaucugca gcccaaucug uacgugguug cagaacuguu cacugggucc     1680

gaggaccucg acaauguguu cgugaccaga cuggggaucu ccucccugau ccgggaagcc     1740

augucggccu acaacuccca ugaagagggc cgccuggugu accgcuacgg gggagaaccc     1800

guggggagcu ucgugcagcc uugccuccgc ccgcugaugc cugccaucgc ccacgcccug     1860

uucauggaua ucacucauga caacgaaugu cccauugugc aucgcucggc cuacgacgca     1920

cugccuucga ccacuaucgu guccauggcc ugcugcgccu ccgggagcac caggggauac     1980

gacgaacucg ugccgcacca gaucagcgug guguccgaag agagauucua uaccaagugg     2040

aaccccgaag cgcugcccag caauaccggg gaagugaacu uccaguccgg uauuaucgcc     2100

gcucgcugug cgaucagcaa gcuccaccag gagcucggug ccaagggauu cauucaaguc     2160

uacguggacc aggucgacga agauaucgug gccgugacca ggcacucacc uuccauucac     2220

caauccgugg ucgccguguc ccggacugcu uuucggaacc ccaagacuuc guucuacucg     2280

aaagaagugc cacagaugug uaucccgggg aaaaucgaag aggucguccu cgaagcccgg     2340

accauugaga ggaacaccaa gccuuaccgg aaagacgaga acucuaucaa cgggaccccu     2400

gauauuacug uggagauccg cgaacacauc cagcugaacg aaucaaagau cgucaagcag     2460

gcuggagugg cgaccaaggg acccaacgag uacauccagg agaucgaauu ugaaaaccuc     2520

uccccuggcu ccgugauuau cuuccgggug ucccuggacc cucacgccca aguggccgug     2580

ggaauucuca gaaaccaccu gacucaguuc ucaccccacu uuaagucugg gucccuggcg     2640

guggacaacg ccgauccgau cuugaaaauc ccuuucgcaa gccuggccuc ccgccugacu     2700

uuggccgagc ugaaccagau ccuguaccgc ugugaaucag aggaaaagga ggacgggggu     2760

ggcuguuacg auauccccaa cugguccgcu uugaaauacg cgggacugca ggggcugaug     2820

uccgugcugg cggaaaucag accgaagaac gaucuggggc accccuucug caacaacuug     2880

cgguccggag acuggaugau cgauuacguc agcaaccggu ugaucagcag aagcgguacu     2940

aucgccgagg ucggaaagug gcugcaggcc auguucuucu accugaagca gaucccucga     3000

uaccucaucc ccuguuacuu cgacgccauu uugaucgggg ccuacaccac ccugcuggac     3060

acugccugga agcagaugag caguuuugug caaaaugggu cgaccuucgu gaagcaccuu     3120

uccuugggcu cagugcagcu cugcggcgug gggaaguucc ccucgcugcc cauucugucc     3180

ccggcccuga uggacguccc uuaccggcug aacgagauua ccaaggagaa ggagcagugc     3240

uguguuuccc uggcugccgg gcugccacac uucucguccg ggaucuuccg gugcuggggc     3300

cgcgauaccu ucauugcgcu gcgggguauc cugcuuauca ccggucgcua cguggaggcu     3360

cggaacauua uccuugcauu cgccgguacc cugagacacg gucugauccc gaaucuucuc     3420

ggggaaggaa ucuacgcaag auacaacugc cgggacgccg ugugguggug gcuccagugc     3480

auucaggacu auugcaagau ggugccgaac ggacuugaca uccugaagug cccagugucg     3540

aggauguacc cuaccgacga cagcgcuccu cugccggccg ggacccugga ccaaccccug     3600

uucgaaguca uccaagaggc uaugcagaag cacaugcagg guauucaguu ccgggaacgg     3660

aacgcggggc cccagauuga uaggaacaug aaggacgagg guuucaacau cacugccggc     3720

guggacgaag aaacuggguu uguguacgga ggaaacagau ucaacugcgg uaccuggaug     3780

gacaagaugg gagaauccga ucgcgcgcgc aacagaggga ucccggcaac cccgcgggac     3840

ggauccgcgg uggaaauugu gggacugagc aagagcgccg ugcgguggcu ccuggaacug     3900

uccaaaaaga acaucuuccc cuaccacgaa gugaccguga agcggcacgg aaaggccauc     3960

aaagucucau acgaugaaug gaaucggaag auccaggaua acuucgagaa gcuguuucac     4020

guguccgagg aucccuccga ucucaacgaa aagcauccga aucucgugca caagcgcggg     4080

aucuacaagg acucguacgg ggcguccuca ccuuggugcg acuaucagcu gcggccuaac     4140

uucacuauug cgauggucgu ggccccggag uuauucacaa cggagaaggc cuggaaggcc     4200

cuugaaauug cggagaagaa gcugcugggg ccucucggga ugaaaacccu ggauccggac     4260

gacauggugu acugcggaau cuacgacaac gcccuugaca acgauaacua caaucuggcc     4320

aagggguuca auuaccacca ggggccggaa uggcucuggc ccauugggua cuuccugcgc     4380

gccaagcugu acuucucacg gcugaugggg ccagagacua ccgccaagac uaucguccuc     4440

gugaaaaacg ugcugucccg gcacuacgug caucuggaga ggagcccuug gaagggacug     4500

ccagagcuga cgaacgagaa cgcgcaguac ugccccuucu ccugcgaaac ccaggcuugg     4560

ucgauugcca cuauacugga aaccuuauau gaccuguag                            4599


<210>  29
<211>  4599
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Codon-Optimized AGL Coding Sequence

<400>  29
augggacacu caaagcaaau ccgcauucug cugcugaacg agauggaaaa gcuggaaaag       60

acucuguucc ggcuggaaca ggguuacgag cugcaguuuc ggcucggccc aaccuugcaa      120

gggaaggccg ucacugucua caccaacuac ccuuuuccgg gggagacuuu caaccgcgaa      180

aaguuccgcu cccuggauug ggaaaacccc acugaacggg aggaugacag cgacaaguac      240

ugcaaacuga accuucagca guccggcagc uuccaauacu acuuccugca aggaaacgaa      300

aaguccggcg gcgguuacau cguggucgac cccauucuga gagugggagc cgauaaucau      360

gugcugcccc uggacugcgu cacccugcaa acuuuccugg cuaagugccu gggaccguuc      420

gaugaguggg aauccaggcu ccgcguggcg aaggagucgg gcuacaacau gauucauuuc      480

acuccccuuc aaacucuggg gcugagucgc agcuguuacu cccuggccaa ccagcuugaa      540

cugaacccag acuuuucccg gccaaacaga aaguacaccu ggaacgacgu gggacaauug      600

guggagaagc uuaagaagga auggaacgug aucugcauca ccgauguggu guauaaccac      660

acugccgcga auuccaagug gauccaggaa caccccgagu gugcuuacaa ccuugugaac      720

agcccucacc uuaagccggc cugggugcug gaucgggcgc uguggagauu cuccugcgac      780

guggccgaag ggaaguacaa agaaaaggga auccccgccc ugauugaaaa ugaccaccau      840

augaacucca uucggaaaau cauuugggaa gauaucuuuc ccaagcugaa gcucugggag      900

uucuuucaag uggaugugaa caaggcugug gagcaguucc ggcggcugcu gacccaggag      960

aaccgccgcg ugaccaaguc cgacccuaac cagcacuuga ccaucauaca ggacccggaa     1020

uaccggagau ucggcugcac ugucgacaug aacauugccc ucacuaccuu caucccgcau     1080

gacaagggac ccgcugccau cgaagagugc ugcaacuggu uccacaagcg gauggaagaa     1140

cugaacucug aaaagcacag gcugaucaac uaccaccagg aacaggcugu gaacugccug     1200

cugggcaacg uguucuacga gagacucgca ggacacggac cgaagcuggg cccugugacc     1260

cggaagcauc cucuggucac ccgcuacuuc accuucccgu ucgaagagau cgacuuuucg     1320

auggaagaau cgaugaucca ccucccuaac aaggccugcu uccucauggc gcacaacggc     1380

ugggucaugg gcgacgaccc gcugagaaac uucgccgagc ccgggagcga aguguaccuc     1440

cggcgggaac uuauuugcug gggagauagc gugaagcuua gauauggcaa caagccugag     1500

gacugcccau accugugggc gcacaugaag aaguacacug aaauuaccgc gaccuacuuc     1560

caaggagucc gacucgacaa cugccacagc accccacuuc acgucgcgga guacauguug     1620

gaugccgcac ggaaucucca gcccaaucug uaugucgugg cugaacuguu cacuggaucc     1680

gaggaccuug acaauguguu cgugacuaga cuggggaucu ccagccugau ccgggaagcu     1740

auguccgcgu acaacuccca cgaagaggga cggcuggugu accgcuacgg cggagagccc     1800

gugggaagcu ucgugcagcc cugccugcgg ccucugaugc cggccaucgc ucacgcccug     1860

uucauggaua ucacucacga caaugagugu ccuaucgugc acaggagcgc guacgacgcc     1920

cugcccucca cuacuaucgu gucgauggcc ugcugcgcaa gcgguucuac ccgcgguuac     1980

gacgagcuug ucccgcacca aauauccgug gugucagagg aacgguucua caccaagugg     2040

aacccggagg cccugccuuc aaacaccggc gaagugaacu uccaguccgg aaucauugcc     2100

gcccgcugug ccauuucaaa guugcaccag gagcugggcg ccaagggauu cauucagguc     2160

uacguugacc aggucgacga agauaucgug gccguuacua gacauucacc gagcauccau     2220

cagagcgugg ucgcagucag caggacugcc uuccgcaacc cgaaaaccuc guucuacucc     2280

aaggaagugc cccagaugug uaucccggga aaaauugagg aaguggugcu ggaggcccgg     2340

accaucgagc ggaacacuaa gcccuaccgg aaggacgaga auucaaucaa cggaaccccu     2400

gacaucaccg uggagauccg cgagcauauc caacugaacg agucgaagau cgucaagcag     2460

gcuggggugg caacuaaggg cccuaacgag uacauucagg agauugaauu cgagaaccug     2520

ucccccgggu ccgugaucau uuuccgcgug ucccuggacc cacaugcuca aguagcagug     2580

gggauccuga gaaaccaccu gacccaguuu agcccgcacu ucaaguccgg aucccuggcc     2640

guggauaacg ccgacccgau ccugaagauc cccuuugcau cccuggcuuc ccggcugacc     2700

uuggccgaac ugaaccagau ucuguaccgc ugcgaaucag aggaaaagga ggacggaggc     2760

ggaugcuacg auauccccaa uuggucggcg cugaaguacg ccggccuuca aggacugaug     2820

uccgugcugg ccgagaucag gccgaagaau gaccugggac acccguucug caacaacuug     2880

agaagcgggg acuggaugau ugauuacgug ucgaaccggc ugaucucccg gagcggcacc     2940

aucgcggaag ucggaaagug gcuccaggcc auguucuucu accugaagca gaucccccgc     3000

uaccugaucc ccugcuacuu cgacgcgauc uugauugggg cauacaccac ucugcuugac     3060

accgcuugga agcagauguc cuccuucgug caaaacggau ccaccuucgu gaagcaccug     3120

ucccuuggau cagugcagcu gugcggcgug ggaaaguucc cuucccuucc cauccugucc     3180

ccugcgcuga uggacgugcc guaccggcuc aacgagauca ccaaggaaaa ggaacagugc     3240

ugcgugucac uggcagccgg ccuuccgcau uuuucgagcg gaauuuucag auguuggggc     3300

agagacaccu ucauugcgcu gcgcgguauc cugcugauua ccggcagaua cguggaagcc     3360

agaaacauua uccuggcguu ugcugguacu cugcggcacg gacugauucc uaaccuguug     3420

ggagagggga ucuacgcccg guacaauugc agagaugccg ugugguggug gcugcagugc     3480

auccaggacu acugcaagau ggugcccaac ggacuugaca uucugaagug cccggugucg     3540

cgcauguacc ccaccgacga cucugcgccc cugccggccg guacccugga ucagccgcug     3600

uucgaaguga uccaggaagc caugcaaaag cacaugcagg gaauucaguu cagggaacgg     3660

aacgcaggcc cgcaaaucga ccggaacaug aaggacgaag gcuucaacau uaccgccggc     3720

guggacgagg aaaccggcuu cguguacggc ggcaaccggu ucaauugcgg uacuuggaug     3780

gacaagaugg gagaaagcga ccgcgccagg aaucggggca uuccugccac cccgcgggac     3840

gguagcgcgg uggagaucgu gggccuuucg aaguccgcgg uccgcuggcu ucuggagcug     3900

ucuaagaaaa acaucuuccc uuaccacgag gucaccguga aacgccacgg aaaggccauc     3960

aagguguccu acgacgaaug gaacaggaag auccaggaca acuuugagaa gcuguuucac     4020

gugucggaag auccguccga ccugaacgaa aagcacccca accuugucca uaagcgcggu     4080

aucuacaaag auucguaugg ugcauccucc ccuuggugcg acuaccaacu ccggccgaac     4140

uucaccaucg caaugguggu ggccccggag cuguucacca cugaaaaggc cuggaaggcc     4200

cuggaaaucg ccgaaaagaa gcugcuggga ccgcugggga ugaaaacccu ggaccccgau     4260

gauauggugu acugcgggau cuacgacaac gcccuggaua acgacaacua caaccuggcc     4320

aagggcuuca acuaccauca ggguccggag uggcuguggc caaucggaua cuuccugagg     4380

gccaagcugu acuucucccg cuugaugggc cccgaaacua ccgcaaagac uaucgugcuc     4440

gugaagaacg uccugucccg gcacuacgug caucuggaac ggucgccgug gaaaggccug     4500

ccagaguuga ccaacgagaa ugcccaguau ugcccguucu caugcgaaac ccaagccugg     4560

agcauugcca cuauucugga aacccucuac gaccuguag                            4599


<210>  30
<211>  4599
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Codon-Optimized AGL Coding Sequence

<400>  30
augggacacu cgaaacagau cagaauccug uugcucaacg aaauggagaa gcucgaaaag       60

acccuguucc ggcuggagca ggguuacgag cugcaguucc gccugggucc gacucuacaa      120

gggaaagcag ugacggucua caccaacuac ccguuucccg gagaaaccuu caaccgggag      180

aaguuccggu cccuggacug ggagaacccg accgaacgag aggaugacuc agauaaguac      240

ugcaagcuga acuugcaaca guccggguca uuccaguacu acuuucugca agggaacgag      300

aagucaggag ggggcuacau cguggucgac ccgauacugc gcgugggagc cgacaaucac      360

guccugccgc uggacugcgu gacccugcaa accuuccucg ccaaaugucu ggggccguuc      420

gaugaguggg aaagccgccu cagagucgca aaggaguccg gauacaacau gauucacuuc      480

acuccgcugc aaacacucgg ucugucccgg ucgugcuauu cucuggcgaa ccagcuggag      540

cuuaaucccg acuuuucccg cccgaaccgg aaguacaccu ggaacgacgu cgggcagcuu      600

guggaaaagc ugaagaagga guggaacgug aucugcauca cugauguggu guacaaccac      660

acggcugcca acucgaagug gauccaagag caucccgagu gcgcguacaa cuuggugaac      720

agcccgcauc ugaagccugc uugggugcug gacagagccc ucuggagauu cagcugcgac      780

guggccgagg ggaaguacaa agaaaagggg auuccggccu ugauugagaa cgaccaucac      840

augaacucaa uccgcaagau cauuugggag gauaucuucc cuaagcuuaa guugugggag      900

uucuuccaag uggacguaaa caaggcagug gagcaguuca gaaggcugcu gacucaagaa      960

aacagacgcg ucacuaaguc cgacccgaac cagcaccuua ccaucaucca agacccggag     1020

uaccgccggu ucggcugcac cgucgauaug aacauagccc ugaccacuuu caucccccau     1080

gacaaggggc cggcggcaau cgaggaaugc uguaacuggu uucauaagcg gauggaggaa     1140

cugaauuccg agaagcaccg gcugauuaac uaccaccagg aacaggcagu gaacugccug     1200

cugggcaacg uguucuacga acggcuggcu ggacacggac cgaagcuggg ucccgugacu     1260

agaaagcauc cgcucgucac ucgcuacuuc accuucccgu uugaggagau ugacuucucc     1320

auggaagaau ccaugaucca cuugccgaac aaggcuugcu uccugauggc gcacaacgga     1380

ugggucaugg gcgacgaccc gcugaggaau uucgcggagc cggguucgga aguguaccug     1440

agaagggaac ucauuugcug gggagacucc gucaagcugc gcuaugggaa caagcccgag     1500

gauugccccu accugugggc ucacaugaag aaguacacgg aaaucaccgc cacguacuuc     1560

cagggagucc ggcuggacaa uugccacucc accccccucc auguggccga guacaugcug     1620

gaugcagcgc gcaaucugca gccgaaucug uacgugguug cagagcuguu cacugggucc     1680

gaggaccucg acaacguguu cgugacuaga uuggggaucu ccucccucau ccgggaagcc     1740

augucggccu acaacuccca ugaggagggg aggcuggugu acagauacgg cggcgaaccc     1800

gugggaagcu ucgugcagcc gugccuccgg ccgcugaugc cggccaucgc ccacgcccug     1860

uucauggaua ucacucacga caacgaaugc ccgaucgugc aucgcucggc cuacgacgca     1920

cugccgucca ccacuaucgu guccauggca ugcugcgccu ccgggagcac ccgcggauac     1980

gaugagcucg ugccgcacca gauuagcgug guguccgaag aacgcuucua uaccaagugg     2040

aaccccgaag cccugccguc caauaccggg gaagugaacu uccaguccgg uauuaucgcc     2100

gcucgcugug cgaucucgaa acuccaccaa gagcucggug ccaagggguu cauucagguc     2160

uacguggauc aggucgacga ggauauugug gcagugacca ggcacucacc uagcauccac     2220

caauccgugg ucgccguguc acgcacugcg uuucggaacc ccaagaccuc guucuacucg     2280

aaagaagugc cgcagaugug uaucccggga aagaucgaag aggucgugcu ggaagcacgg     2340

accauugaga ggaacaccaa gccuuaccgg aaagacgaga acucuaucaa cgggaccccg     2400

gauaucacug uggagauucg cgaacacauc cagcugaacg aaucaaagau cgucaagcag     2460

gcuggagugg ccaccaaggg acccaacgag uacauccagg agaucgaauu ugaaaaccuc     2520

uccccggggu ccgugaucau cuuccgggug ucccuggacc cccacgccca aguggccgug     2580

ggaauucuca gaaaccaccu gacccaguuc ucaccccacu uuaagucggg uucccuggcc     2640

guggacaacg ccgauccgau ccucaagauc ccguucgcgu cgcuggccuc ccgccucacu     2700

cucgcggaac ugaaccagau ccuguaccgc ugugaaucag aggaaaagga ggacggcggc     2760

ggcuguuacg auauuccgaa uuggucggcu uugaaauacg cgggacuuca ggggcugaug     2820

ucuguccugg cggaaauccg gccgaagaac gaccuggggc acccguucug caacaacuug     2880

cggagcggag auuggaugau cgacuacguc agcaacagac ugaucagccg gagcggcacu     2940

aucgccgagg ucggaaagug guugcaggcc auguucuucu accugaagca gaucccccga     3000

uaccucaucc cguguuacuu cgacgccauc cugaucgggg ccuacaccac ccuccuggac     3060

accgccugga agcagaugag caguuuugug caaaacgggu ccaccuucgu gaagcaccuu     3120

ucccugggcu cagugcagcu gugcggcgug ggaaaguucc ccucgcugcc cauucugagc     3180

ccggcccuga uggacguccc cuaccggcug aacgagauca ccaaggagaa ggagcagugc     3240

uguguguccc uggcugccgg gcugccgcac uuuucguccg gcaucuuccg gugcuggggg     3300

cgggauaccu ucauugcccu gcggggaauc cuucuuauca ccggucgcua uguggaggcu     3360

cggaacauua uucuggcguu cgccggaacc cugagacacg ggcugauucc gaaccucuug     3420

ggggaaggga ucuacgcccg cuacaacugu cgggacgccg ugugguggug gcuccagugc     3480

auucaggacu auugcaagau ggugcccaac gggcuggaca uccugaagug cccggugucg     3540

aggauguauc cgaccgacga cagcgcaccc cugccggccg ggacccucga ccaaccccug     3600

uucgaaguca uucaagaggc uaugcagaag cacaugcagg guauucaguu ccgggaacgg     3660

aacgcggggc cccagauuga uaggaacaug aaagacgagg guuucaacau cacugccggc     3720

guggacgaag aaaccgguuu uguguacgga ggaaaccggu ucaacugcgg uaccuggaug     3780

gauaagaugg gagaaucaga ucgcgcgcgc aacagaggga ucccggcaac cccgcgggac     3840

ggaucggcug uggaaauugu gggacugagc aagagcgccg ugcgguggcu gcuggaacug     3900

agcaaaaaga acaucuuccc cuaccacgaa gugaccguga agcggcacgg aaaggccauc     3960

aaagucuccu acgaugaaug gaauaggaag auccaggaua acuucgagaa gcuuuuucac     4020

guguccgagg aucccuccga ucugaacgag aagcauccga aucucgugca uaagaggggg     4080

aucuacaagg acuccuacgg agcguccucc ccuuggugcg acuaucagcu gcggccuaac     4140

uucaccauug ccauggucgu ggccccggag cucuuuacaa ccgagaaggc cuggaaggcc     4200

cucgaaauug ccgaaaagaa gcugcugggg cccuugggga ugaaaacccu ggauccggac     4260

gacauggugu acugcggaau cuacgacaac gcccuggaca acgacaacua caaucuggcg     4320

aagggcuuca auuaccacca ggggccggaa uggcucuggc cgauugggua cuuccugcgc     4380

gccaagcugu acuucucacg gcugauggga ccggagacua ccgccaagac caucguccuc     4440

gugaagaacg ugcugucgcg gcacuacgug caccuggaga ggagccccug gaaggggcuu     4500

cccgagcuga cgaacgagaa cgcgcaguac ugucccuucu ccugcgaaac ccaagccugg     4560

uccauugcca cuauacugga aaccuuauau gaccuguag                            4599


<210>  31
<211>  4599
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Codon-Optimized AGL Coding Sequence

<400>  31
augggccaca gcaagcagau ccggaucuug cugcugaacg agauggagaa gcuggagaag       60

acccuguuca ggcuggagca gggcuacgag cugcaguucc gguugggccc caccuugcag      120

ggcaaggccg ugaccgugua caccaacuac cccuuccccg gcgaaaccuu caacagggag      180

aaguuccggu cccuggacug ggagaacccc accgagaggg aggacgacuc cgacaaguac      240

ugcaagcuga accugcagca guccggcucc uuccaguacu acuuccugca gggcaacgag      300

aaaagcggcg gcggcuacau cgugguggac cccaucuugc gggugggcgc cgacaaccac      360

gugcugcccu uggacugcgu gacccugcag accuucuugg ccaagugcuu gggccccuuc      420

gacgaguggg agagcaggcu gaggguggcc aaggaguccg gcuacaacau gauccacuuc      480

acccccuugc agacccuggg ccuguccagg uccugcuacu cccuggccaa ccaguuggag      540

uugaaccccg acuucuccag gcccaacagg aaguacaccu ggaacgacgu gggccagcug      600

guggagaagu ugaagaagga guggaacgug aucugcauca ccgacguggu guacaaccac      660

accgccgcca acagcaagug gauccaggag caccccgagu gcgccuacaa ccuggugaac      720

uccccccacu ugaagcccgc cuggguguug gacagggccc uguggcgguu cuccugcgac      780

guggccgagg gcaaguacaa ggagaagggc auccccgccu ugaucgagaa cgaccaccac      840

augaacucca uccggaagau caucugggag gacaucuucc ccaagcugaa gcugugggag      900

uucuuccagg uggacgugaa caaggccgug gagcaguuca ggaggcugcu gacccaggag      960

aacaggcggg ugaccaaguc cgaccccaac cagcaccuga ccaucaucca ggaccccgag     1020

uacaggcggu ucggcugcac cguggacaug aacaucgccc ugaccaccuu caucccccac     1080

gacaagggcc ccgccgccau cgaggagugc ugcaacuggu uccacaagag gauggaggag     1140

uugaacuccg agaagcaccg gcugaucaac uaccaccagg agcaggccgu gaacugccug     1200

uugggcaacg uguucuacga gcggcuggcc ggccacggcc ccaagcuggg ccccgugacc     1260

aggaagcacc ccuuggugac cagguacuuc accuuccccu ucgaggagau cgacuucucc     1320

auggaggagu ccaugaucca ccugcccaac aaggccugcu uccugauggc ccacaacggc     1380

ugggugaugg gcgacgaccc ccugcggaac uucgccgagc ccggcuccga gguguaccug     1440

aggagggagc ugaucugcug gggcgacagc gugaaguugc gguacggcaa caagcccgag     1500

gacugccccu accugugggc ccacaugaag aaguacaccg agaucaccgc caccuacuuc     1560

cagggcgugc ggcuggacaa cugccacucc accccccugc acguggccga guacauguug     1620

gacgccgcca ggaacuugca gcccaacuug uacguggugg ccgagcuguu caccggcagc     1680

gaggaccugg acaacguguu cgugaccagg cugggcauca gcuccuugau cagggaggcc     1740

augagcgccu acaacagcca cgaggagggc agguuggugu accgguacgg cggcgagccc     1800

gugggcuccu ucgugcagcc cugcuugagg cccuugaugc ccgccaucgc ccacgcccug     1860

uucauggaca ucacccacga caacgagugc cccaucgugc acagguccgc cuacgacgcc     1920

cugcccagca ccaccaucgu guccauggcc ugcugcgcca gcggcagcac caggggcuac     1980

gacgaguugg ugccccacca gaucuccgug guguccgagg agcgguucua caccaagugg     2040

aaccccgagg ccuugcccuc caacaccggc gaggugaacu uccagagcgg caucaucgcc     2100

gccaggugcg ccaucagcaa gcugcaccag gagcugggcg ccaagggcuu cauccaggug     2160

uacguggacc agguggacga ggacaucgug gccgugacca ggcacucccc cagcauccac     2220

caguccgugg uggccguguc caggaccgcc uucaggaacc ccaagaccuc cuucuacagc     2280

aaggaggugc cccagaugug cauccccggc aagaucgagg agguggugcu ggaggccagg     2340

accaucgaga ggaacaccaa gcccuacagg aaggacgaga acuccaucaa cggcaccccc     2400

gacaucaccg uggagaucag ggagcacauc cagcugaacg agagcaagau cgugaagcag     2460

gccggcgugg ccaccaaggg ccccaacgag uacauccagg agaucgaguu cgagaacuug     2520

ucccccggca gcgugaucau cuucagggug agccuggacc cccacgccca gguggccgug     2580

ggcauccugc ggaaccaccu gacccaguuc agcccccacu ucaaguccgg cagccuggcc     2640

guggacaacg ccgaccccau cuugaagauc cccuucgccu cccuggccuc cagguugacc     2700

uuggccgagc ugaaccagau ccuguaccgg ugcgaguccg aggagaagga ggacggcggc     2760

ggcugcuacg acauccccaa cugguccgcc cugaaguacg ccggccugca gggcuugaug     2820

uccguguugg ccgagaucag gcccaagaac gacuugggcc accccuucug caacaacuug     2880

agguccggcg acuggaugau cgacuacgug agcaaccggc ugaucucccg guccggcacc     2940

aucgccgagg ugggcaagug guugcaggcc auguucuucu accugaagca gaucccccgg     3000

uaccugaucc ccugcuacuu cgacgccauc uugaucggcg ccuacaccac ccugcuggac     3060

accgccugga agcagauguc cagcuucgug cagaacggcu ccaccuucgu gaagcaccug     3120

uccuugggcu ccgugcagcu gugcggcgug ggcaaguucc ccucccugcc cauccugucc     3180

cccgcccuga uggacgugcc cuacagguug aacgagauca ccaaggagaa ggagcagugc     3240

ugcguguccc uggccgccgg cuugccccac uucuccuccg gcaucuuccg gugcuggggc     3300

agggacaccu ucaucgcccu gaggggcauc cugcugauca ccggccggua cguggaggcc     3360

aggaacauca ucuuggccuu cgccggcacc cugaggcacg gccugauccc caaccugcug     3420

ggcgagggca ucuacgccag guacaacugc cgggacgccg ugugguggug gcugcagugc     3480

auccaggacu acugcaagau ggugcccaac ggccuggaca uccugaagug ccccgugucc     3540

aggauguacc ccaccgacga cuccgccccc uugcccgccg gcacccugga ccagcccuug     3600

uucgagguga uccaggaggc caugcagaag cacaugcagg gcauccaguu ccgggagagg     3660

aacgccggcc cccagaucga ccggaacaug aaggacgagg gcuucaacau caccgccggc     3720

guggacgagg aaaccggcuu cguguacggc ggcaaccggu ucaacugcgg caccuggaug     3780

gacaagaugg gcgagagcga cagggccagg aacaggggca uccccgccac ccccagggac     3840

ggcuccgccg uggagaucgu gggccugagc aaguccgccg ugcggugguu gcuggaguug     3900

uccaagaaga acaucuuccc cuaccacgag gugaccguga agaggcacgg caaggccauc     3960

aagguguccu acgacgagug gaacaggaag auccaggaca acuucgagaa gcuguuccac     4020

guguccgagg accccuccga cuugaacgag aagcacccca accuggugca caagcggggc     4080

aucuacaagg acagcuacgg cgccuccagc cccuggugcg acuaccagcu gaggcccaac     4140

uucaccaucg ccaugguggu ggcccccgag cuguucacca ccgagaaggc cuggaaggcc     4200

uuggagaucg ccgagaagaa guugcugggc ccccugggca ugaagaccuu ggaccccgac     4260

gacauggugu acugcggcau cuacgacaac gccuuggaca acgacaacua caaccuggcc     4320

aagggcuuca acuaccacca gggccccgag uggcuguggc ccaucggcua cuuccugcgg     4380

gccaaguugu acuucuccag guugaugggc cccgaaacca ccgccaagac caucguguug     4440

gugaagaacg ugcugucccg gcacuacgug caccuggaga ggucccccug gaagggccug     4500

cccgagcuga ccaacgagaa cgcccaguac ugccccuuca gcugcgaaac ccaggccugg     4560

uccaucgcca ccauccugga aacccuguac gacuuguag                            4599


<210>  32
<211>  4599
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Codon-Optimized AGL Coding Sequence

<400>  32
augggacaua gcaagcagau ccggaucuug cugcugaaug aaauggaaaa gcuggaaaag       60

acccuguuca gacuggaaca gggauacgaa cugcaguucc gguugggacc uaccuugcag      120

ggaaaggcug ugaccgugua caccaauuac ccuuucccug gagaaaccuu caauagagaa      180

aaguucagau cucuagauug ggaaaauccu accgaaagag aagaugauuc ugauaaguac      240

ugcaagcuga aucugcagca gucuggaucu uuccaguacu acuuccugca gggaaaugaa      300

aagagcggag gaggauacau cgugguggau ccuaucuugc gggugggagc ugauaaucau      360

gugcugccuu uggauugcgu gacccugcag accuucuugg cuaagugcuu gggaccuuuc      420

gaugaauggg aaagcagacu gagaguggcu aaggaaucug gauacaauau gauccauuuc      480

accccuuugc agacccuggg acugucuaga ucuugcuacu cucuggcuaa ucaguuggaa      540

uugaauccug auuucucuag accuaauaga aaguacaccu ggaaugaugu gggacagcug      600

guggaaaagu ugaagaagga auggaaugug aucugcauca ccgauguggu guacaaucau      660

accgcugcua auagcaagug gauccaggaa cauccugaau gcgcuuacaa ucuggugaau      720

ucuccucauu ugaagccugc uuggguguug gauagagcuc uguggcgguu cucuugcgau      780

guggcugaag gaaaguacaa ggaaaaggga aucccugcuu ugaucgaaaa ugaucaucau      840

augaauucua uccggaagau caucugggaa gauaucuucc cuaagcugaa gcugugggaa      900

uucuuccagg uggaugugaa uaaggcugug gaacaguuca gaagacugcu gacccaggaa      960

aauagacggg ugaccaaguc ugauccuaau cagcaucuga ccaucaucca ggauccugaa     1020

uacagacggu ucggaugcac cguggauaug aauaucgcuc ugaccaccuu caucccucau     1080

gauaagggac cugcugcuau cgaagaaugc ugcaauuggu uccauaagag aauggaagaa     1140

uugaauucug aaaagcaucg gcugaucaau uaccaucagg aacaggcugu gaauugccug     1200

uugggaaaug uguucuacga acggcuggcu ggacauggac cuaagcuggg accugugacc     1260

agaaagcauc cuuuggugac cagauacuuc accuucccuu ucgaagaaau cgauuucucu     1320

auggaagaau cuaugaucca ucugccuaau aaggcuugcu uccugauggc ucauaaugga     1380

ugggugaugg gagaugaucc ucugcggaau uucgcugaac cuggaucuga aguguaccug     1440

agaagagaac ugaucugcug gggagauagc gugaaguugc gguacggaaa uaagccugaa     1500

gauugcccuu accugugggc ucauaugaag aaguacaccg aaaucaccgc uaccuacuuc     1560

cagggagugc ggcuggauaa uugccauucu accccucugc auguggcuga auacauguug     1620

gaugcugcua gaaauuugca gccuaauuug uacguggugg cugaacuguu caccggaagc     1680

gaagaucugg auaauguguu cgugaccaga cugggaauca gcucuuugau cagagaagcu     1740

augagcgcuu acaauagcca ugaagaagga agauuggugu accgguacgg aggagaaccu     1800

gugggaucuu ucgugcagcc uugcuugagg ccuuugaugc cugcuaucgc ucaugcucug     1860

uucauggaua ucacccauga uaaugaaugc ccuaucgugc auagaucugc uuacgaugcu     1920

cugccuagca ccaccaucgu gucuauggcu ugcugcgcua gcggaagcac cagaggauac     1980

gaugaauugg ugccucauca gaucucugug gugucugaag aacgguucua caccaagugg     2040

aauccugaag cuuugccuuc uaauaccgga gaagugaauu uccagagcgg aaucaucgcu     2100

gcuagaugcg cuaucagcaa gcugcaucag gaacugggag cuaagggauu cauccaggug     2160

uacguggauc agguggauga agauaucgug gcugugacca gacauucucc uagcauccau     2220

cagucugugg uggcuguguc uagaaccgcu uucagaaauc cuaagaccuc uuucuacagc     2280

aaggaagugc cucagaugug caucccugga aagaucgaag aaguggugcu ggaagcuaga     2340

accaucgaaa gaaauaccaa gccuuacaga aaggaugaaa auucuaucaa uggaaccccu     2400

gauaucaccg uggaaaucag agaacauauc cagcugaaug aaagcaagau cgugaagcag     2460

gcuggagugg cuaccaaggg accuaaugaa uacauccagg aaaucgaauu cgaaaauuug     2520

ucuccuggaa gcgugaucau cuucagagug agccuggauc cucaugcuca gguggcugug     2580

ggaauccugc ggaaucaucu gacccaguuc agcccucauu ucaagucugg aagccuggcu     2640

guggauaaug cugauccuau cuugaagauc ccuuucgcuu cucuggcuuc uagauugacc     2700

uuggcugaac ugaaucagau ccuguaccgg ugcgaaucug aagaaaagga agauggagga     2760

ggaugcuacg auaucccuaa uuggucugcu cugaaguacg cuggacugca gggauugaug     2820

ucuguguugg cugaaaucag accuaagaau gauuugggac auccuuucug caauaauuug     2880

agaucuggag auuggaugau cgauuacgug agcaaucggc ugaucucucg gucuggaacc     2940

aucgcugaag ugggaaagug guugcaggcu auguucuucu accugaagca gaucccucgg     3000

uaccugaucc cuugcuacuu cgaugcuauc uugaucggag cuuacaccac ccugcuggau     3060

accgcuugga agcagauguc uagcuucgug cagaauggau cuaccuucgu gaagcaucug     3120

ucuuugggau cugugcagcu gugcggagug ggaaaguucc cuucucugcc uauccugucu     3180

ccugcucuga uggaugugcc uuacagauug aaugaaauca ccaaggaaaa ggaacagugc     3240

ugcgugucuc uggcugcugg auugccucau uucucuucug gaaucuuccg gugcugggga     3300

agagauaccu ucaucgcucu gagaggaauc cugcugauca ccggacggua cguggaagcu     3360

agaaauauca ucuuggcuuu cgcuggaacc cugagacaug gacugauccc uaaucugcug     3420

ggagaaggaa ucuacgcuag auacaauugc cgggaugcug ugugguggug gcugcagugc     3480

auccaggauu acugcaagau ggugccuaau ggacuggaua uccugaagug cccugugucu     3540

agaauguacc cuaccgauga uucugcuccu uugccugcug gaacccugga ucagccuuug     3600

uucgaaguga uccaggaagc uaugcagaag cauaugcagg gaauccaguu ccgggaaaga     3660

aaugcuggac cucagaucga ucggaauaug aaggaugaag gauucaauau caccgcugga     3720

guggaugaag aaaccggauu cguguacgga ggaaaucggu ucaauugcgg aaccuggaug     3780

gauaagaugg gagaaagcga uagagcuaga aauagaggaa ucccugcuac cccuagagau     3840

ggaucugcug uggaaaucgu gggacugagc aagucugcug ugcggugguu gcuggaauug     3900

ucuaagaaga auaucuuccc uuaccaugaa gugaccguga agagacaugg aaaggcuauc     3960

aaggugucuu acgaugaaug gaauagaaag auccaggaua auuucgaaaa gcuguuccau     4020

gugucugaag auccuucuga uuugaaugaa aagcauccua aucuggugca uaagcgggga     4080

aucuacaagg auagcuacgg agcuucuagc ccuuggugcg auuaccagcu gaggccuaau     4140

uucaccaucg cuaugguggu ggcuccugaa cuguucacca ccgaaaaggc uuggaaggcu     4200

uuggaaaucg cugaaaagaa guugcuggga ccucugggaa ugaagaccuu ggauccugau     4260

gauauggugu acugcggaau cuacgauaau gcuuuggaua augauaauua caaucuggcu     4320

aagggauuca auuaccauca gggaccugaa uggcuguggc cuaucggaua cuuccugcgg     4380

gcuaaguugu acuucucuag auugauggga ccugaaacca ccgcuaagac caucguguug     4440

gugaagaaug ugcugucucg gcauuacgug caucuggaaa gaucuccuug gaagggacug     4500

ccugaacuga ccaaugaaaa ugcucaguac ugcccuuuca gcugcgaaac ccaggcuugg     4560

ucuaucgcua ccauccugga aacccuguac gauuuguag                            4599


<210>  33
<211>  158
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Modified Xenopus beta-globin 3'UTR


<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  n is unlocked nucleomonomer UNA-U

<220>
<221>  misc_feature
<222>  (157)..(157)
<223>  n is unlocked nucleomonomer UNA-A

<400>  33
cnagugacug acuaggaucu gguuaccacu aaaccagccu caagaacacc cgaauggagu       60

cucuaagcua cauaauacca acuuacacuu acaaaauguu gucccccaaa auguagccau      120

ucguaucugc uccuaauaaa aagaaaguuu cuucacnu                              158


<210>  34
<211>  158
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Modified Xenopus beta-globin 3'UTR


<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  n is unlocked nucleomonomer UNA-U

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  n is unlocked nucleomonomer UNA-A

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  n is unlocked nucleomonomer UNA-G

<220>
<221>  misc_feature
<222>  (155)..(155)
<223>  n is unlocked nucleomonomer UNA-A

<220>
<221>  misc_feature
<222>  (156)..(156)
<223>  n is unlocked nucleomonomer UNA-C

<220>
<221>  misc_feature
<222>  (157)..(157)
<223>  n is unlocked nucleomonomer UNA-A

<400>  34
cnnnugacug acuaggaucu gguuaccacu aaaccagccu caagaacacc cgaauggagu       60

cucuaagcua cauaauacca acuuacacuu acaaaauguu gucccccaaa auguagccau      120

ucguaucugc uccuaauaaa aagaaaguuu cuucnnnu                              158


<210>  35
<211>  158
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Modified Xenopus beta-globin 3'UTR


<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  n is unlocked nucleomonomer UNA-U

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  n is unlocked nucleomonomer UNA-C

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  n is unlocked nucleomonomer UNA-A

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  n is unlocked nucleomonomer UNA-U

<220>
<221>  misc_feature
<222>  (26)..(26)
<223>  n is unlocked nucleomonomer UNA-C

<220>
<221>  misc_feature
<222>  (32)..(32)
<223>  n is unlocked nucleomonomer UNA-A

<220>
<221>  misc_feature
<222>  (38)..(38)
<223>  n is unlocked nucleomonomer UNA-C

<220>
<221>  misc_feature
<222>  (44)..(44)
<223>  n is unlocked nucleomonomer UNA-G

<220>
<221>  misc_feature
<222>  (50)..(50)
<223>  n is unlocked nucleomonomer UNA-C

<220>
<221>  misc_feature
<222>  (56)..(56)
<223>  n is unlocked nucleomonomer UNA-G

<220>
<221>  misc_feature
<222>  (62)..(62)
<223>  n is unlocked nucleomonomer UNA-U

<220>
<221>  misc_feature
<222>  (68)..(68)
<223>  n is unlocked nucleomonomer UNA-C

<220>
<221>  misc_feature
<222>  (74)..(74)
<223>  n is unlocked nucleomonomer UNA-A

<220>
<221>  misc_feature
<222>  (80)..(80)
<223>  n is unlocked nucleomonomer UNA-A

<220>
<221>  misc_feature
<222>  (86)..(86)
<223>  n is unlocked nucleomonomer UNA-C

<220>
<221>  misc_feature
<222>  (92)..(92)
<223>  n is unlocked nucleomonomer UNA-C

<220>
<221>  misc_feature
<222>  (98)..(98)
<223>  n is unlocked nucleomonomer UNA-G

<220>
<221>  misc_feature
<222>  (104)..(104)
<223>  n is unlocked nucleomonomer UNA-C

<220>
<221>  misc_feature
<222>  (110)..(110)
<223>  n is unlocked nucleomonomer UNA-A

<220>
<221>  misc_feature
<222>  (116)..(116)
<223>  n is unlocked nucleomonomer UNA-G

<220>
<221>  misc_feature
<222>  (122)..(122)
<223>  n is unlocked nucleomonomer UNA-C

<220>
<221>  misc_feature
<222>  (128)..(128)
<223>  n is unlocked nucleomonomer UNA-U

<220>
<221>  misc_feature
<222>  (134)..(134)
<223>  n is unlocked nucleomonomer UNA-U

<220>
<221>  misc_feature
<222>  (140)..(140)
<223>  n is unlocked nucleomonomer UNA-A

<220>
<221>  misc_feature
<222>  (146)..(146)
<223>  n is unlocked nucleomonomer UNA-A

<220>
<221>  misc_feature
<222>  (152)..(152)
<223>  n is unlocked nucleomonomer UNA-U

<220>
<221>  misc_feature
<222>  (157)..(157)
<223>  n is unlocked nucleomonomer UNA-A

<400>  35
cnaguganug acunggaucn gguuancacu anaccagncu caanaacacn cgaaungagu       60

cncuaagnua caunauaccn acuuanacuu anaaaaunuu gucncccaan auguanccau      120

unguaucngc uccnaauaan aagaanguuu cnucacnu                              158


<210>  36
<211>  158
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Modified Xenopus beta-globin 3'UTR


<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  n is unlocked nucleomonomer UNA-U

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  n is unlocked nucleomonomer UNA-A

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  n is unlocked nucleomonomer UNA-C

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  n is unlocked nucleomonomer UNA-U

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  n is unlocked nucleomonomer UNA-A

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  n is unlocked nucleomonomer UNA-G

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  n is unlocked nucleomonomer UNA-U

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  n is unlocked nucleomonomer UNA-G

<220>
<221>  misc_feature
<222>  (26)..(27)
<223>  n is unlocked nucleomonomer UNA-C

<220>
<221>  misc_feature
<222>  (32)..(33)
<223>  n is unlocked nucleomonomer UNA-A

<220>
<221>  misc_feature
<222>  (38)..(39)
<223>  n is unlocked nucleomonomer UNA-C

<220>
<221>  misc_feature
<222>  (44)..(44)
<223>  n is unlocked nucleomonomer UNA-G

<220>
<221>  misc_feature
<222>  (45)..(45)
<223>  n is unlocked nucleomonomer UNA-A

<220>
<221>  misc_feature
<222>  (50)..(51)
<223>  n is unlocked nucleomonomer UNA-C

<220>
<221>  misc_feature
<222>  (56)..(57)
<223>  n is unlocked nucleomonomer UNA-G

<220>
<221>  misc_feature
<222>  (62)..(62)
<223>  n is unlocked nucleomonomer UNA-U

<220>
<221>  misc_feature
<222>  (63)..(63)
<223>  n is unlocked nucleomonomer UNA-C

<220>
<221>  misc_feature
<222>  (68)..(68)
<223>  n is unlocked nucleomonomer UNA-C

<220>
<221>  misc_feature
<222>  (69)..(69)
<223>  n is unlocked nucleomonomer UNA-U

<220>
<221>  misc_feature
<222>  (74)..(75)
<223>  n is unlocked nucleomonomer UNA-A

<220>
<221>  misc_feature
<222>  (80)..(81)
<223>  n is unlocked nucleomonomer UNA-A

<220>
<221>  misc_feature
<222>  (86)..(86)
<223>  n is unlocked nucleomonomer UNA-C

<220>
<221>  misc_feature
<222>  (87)..(87)
<223>  n is unlocked nucleomonomer UNA-A

<220>
<221>  misc_feature
<222>  (92)..(92)
<223>  n is unlocked nucleomonomer UNA-C

<220>
<221>  misc_feature
<222>  (93)..(93)
<223>  n is unlocked nucleomonomer UNA-A

<220>
<221>  misc_feature
<222>  (98)..(98)
<223>  n is unlocked nucleomonomer UNA-G

<220>
<221>  misc_feature
<222>  (99)..(99)
<223>  n is unlocked nucleomonomer UNA-U

<220>
<221>  misc_feature
<222>  (104)..(105)
<223>  n is unlocked nucleomonomer UNA-C

<220>
<221>  misc_feature
<222>  (110)..(111)
<223>  n is unlocked nucleomonomer UNA-A

<220>
<221>  misc_feature
<222>  (116)..(116)
<223>  n is unlocked nucleomonomer UNA-G

<220>
<221>  misc_feature
<222>  (117)..(117)
<223>  n is unlocked nucleomonomer UNA-C

<220>
<221>  misc_feature
<222>  (122)..(122)
<223>  n is unlocked nucleomonomer UNA-C

<220>
<221>  misc_feature
<222>  (123)..(123)
<223>  n is unlocked nucleomonomer UNA-G

<220>
<221>  misc_feature
<222>  (128)..(128)
<223>  n is unlocked nucleomonomer UNA-U

<220>
<221>  misc_feature
<222>  (129)..(129)
<223>  n is unlocked nucleomonomer UNA-G

<220>
<221>  misc_feature
<222>  (134)..(134)
<223>  n is unlocked nucleomonomer UNA-U

<220>
<221>  misc_feature
<222>  (135)..(135)
<223>  n is unlocked nucleomonomer UNA-A

<220>
<221>  misc_feature
<222>  (140)..(141)
<223>  n is unlocked nucleomonomer UNA-A

<220>
<221>  misc_feature
<222>  (146)..(146)
<223>  n is unlocked nucleomonomer UNA-A

<220>
<221>  misc_feature
<222>  (147)..(147)
<223>  n is unlocked nucleomonomer UNA-G

<220>
<221>  misc_feature
<222>  (152)..(153)
<223>  n is unlocked nucleomonomer UNA-U

<220>
<221>  misc_feature
<222>  (157)..(157)
<223>  n is unlocked nucleomonomer UNA-A

<400>  36
cnnguganng acunngaucn nguuannacu annccagnnu caannacacn ngaaunnagu       60

cnnuaagnna caunnuaccn ncuuanncuu annaaaunnu gucnnccaan nuguanncau      120

unnuaucnnc uccnnauaan nagaannuuu cnncacnu                              158


<210>  37
<211>  158
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Modified Xenopus beta-globin 3'UTR


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  n is unlocked nucleomonomer UNA-C

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  n is unlocked nucleomonomer UNA-U

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  n is unlocked nucleomonomer UNA-A

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  n is unlocked nucleomonomer UNA-G

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  n is unlocked nucleomonomer UNA-U

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  n is unlocked nucleomonomer UNA-G

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  n is unlocked nucleomonomer UNA-A

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  n is unlocked nucleomonomer UNA-C

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  n is unlocked nucleomonomer UNA-U

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  n is unlocked nucleomonomer UNA-G

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  n is unlocked nucleomonomer UNA-A

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  n is unlocked nucleomonomer UNA-C

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  n is unlocked nucleomonomer UNA-U

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  n is unlocked nucleomonomer UNA-A

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  n is unlocked nucleomonomer UNA-G

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  n is unlocked nucleomonomer UNA-A

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  n is unlocked nucleomonomer UNA-U

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  n is unlocked nucleomonomer UNA-C

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  n is unlocked nucleomonomer UNA-U

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  n is unlocked nucleomonomer UNA-G

<220>
<221>  misc_feature
<222>  (23)..(24)
<223>  n is unlocked nucleomonomer UNA-U

<220>
<221>  misc_feature
<222>  (25)..(25)
<223>  n is unlocked nucleomonomer UNA-A

<220>
<221>  misc_feature
<222>  (26)..(27)
<223>  n is unlocked nucleomonomer UNA-C

<220>
<221>  misc_feature
<222>  (28)..(28)
<223>  n is unlocked nucleomonomer UNA-A

<220>
<221>  misc_feature
<222>  (29)..(29)
<223>  n is unlocked nucleomonomer UNA-C

<220>
<221>  misc_feature
<222>  (30)..(30)
<223>  n is unlocked nucleomonomer UNA-U

<220>
<221>  misc_feature
<222>  (31)..(33)
<223>  n is unlocked nucleomonomer UNA-A

<220>
<221>  misc_feature
<222>  (34)..(35)
<223>  n is unlocked nucleomonomer UNA-C

<220>
<221>  misc_feature
<222>  (36)..(36)
<223>  n is unlocked nucleomonomer UNA-A

<220>
<221>  misc_feature
<222>  (37)..(37)
<223>  n is unlocked nucleomonomer UNA-G

<220>
<221>  misc_feature
<222>  (38)..(39)
<223>  n is unlocked nucleomonomer UNA-C

<220>
<221>  misc_feature
<222>  (40)..(40)
<223>  n is unlocked nucleomonomer UNA-U

<220>
<221>  misc_feature
<222>  (41)..(41)
<223>  n is unlocked nucleomonomer UNA-C

<220>
<221>  misc_feature
<222>  (42)..(43)
<223>  n is unlocked nucleomonomer UNA-A

<220>
<221>  misc_feature
<222>  (44)..(44)
<223>  n is unlocked nucleomonomer UNA-G

<220>
<221>  misc_feature
<222>  (45)..(46)
<223>  n is unlocked nucleomonomer UNA-A

<220>
<221>  misc_feature
<222>  (47)..(47)
<223>  n is unlocked nucleomonomer UNA-C

<220>
<221>  misc_feature
<222>  (48)..(48)
<223>  n is unlocked nucleomonomer UNA-A

<220>
<221>  misc_feature
<222>  (49)..(51)
<223>  n is unlocked nucleomonomer UNA-C

<220>
<221>  misc_feature
<222>  (52)..(52)
<223>  n is unlocked nucleomonomer UNA-G

<220>
<221>  misc_feature
<222>  (53)..(54)
<223>  n is unlocked nucleomonomer UNA-A

<220>
<221>  misc_feature
<222>  (55)..(55)
<223>  n is unlocked nucleomonomer UNA-U

<220>
<221>  misc_feature
<222>  (56)..(57)
<223>  n is unlocked nucleomonomer UNA-G

<220>
<221>  misc_feature
<222>  (58)..(58)
<223>  n is unlocked nucleomonomer UNA-A

<220>
<221>  misc_feature
<222>  (59)..(59)
<223>  n is unlocked nucleomonomer UNA-G

<220>
<221>  misc_feature
<222>  (60)..(60)
<223>  n is unlocked nucleomonomer UNA-U

<220>
<221>  misc_feature
<222>  (61)..(61)
<223>  n is unlocked nucleomonomer UNA-C

<220>
<221>  misc_feature
<222>  (62)..(62)
<223>  n is unlocked nucleomonomer UNA-U

<220>
<221>  misc_feature
<222>  (63)..(63)
<223>  n is unlocked nucleomonomer UNA-C

<220>
<221>  misc_feature
<222>  (64)..(64)
<223>  n is unlocked nucleomonomer UNA-U

<220>
<221>  misc_feature
<222>  (65)..(66)
<223>  n is unlocked nucleomonomer UNA-A

<220>
<221>  misc_feature
<222>  (67)..(67)
<223>  n is unlocked nucleomonomer UNA-G

<220>
<221>  misc_feature
<222>  (68)..(68)
<223>  n is unlocked nucleomonomer UNA-C

<220>
<221>  misc_feature
<222>  (69)..(69)
<223>  n is unlocked nucleomonomer UNA-U

<220>
<221>  misc_feature
<222>  (70)..(70)
<223>  n is unlocked nucleomonomer UNA-A

<220>
<221>  misc_feature
<222>  (71)..(71)
<223>  n is unlocked nucleomonomer UNA-C

<220>
<221>  misc_feature
<222>  (72)..(72)
<223>  n is unlocked nucleomonomer UNA-A

<220>
<221>  misc_feature
<222>  (73)..(73)
<223>  n is unlocked nucleomonomer UNA-U

<220>
<221>  misc_feature
<222>  (74)..(75)
<223>  n is unlocked nucleomonomer UNA-A

<220>
<221>  misc_feature
<222>  (76)..(76)
<223>  n is unlocked nucleomonomer UNA-U

<220>
<221>  misc_feature
<222>  (77)..(77)
<223>  n is unlocked nucleomonomer UNA-A

<220>
<221>  misc_feature
<222>  (78)..(79)
<223>  n is unlocked nucleomonomer UNA-C

<220>
<221>  misc_feature
<222>  (80)..(81)
<223>  n is unlocked nucleomonomer UNA-A

<220>
<221>  misc_feature
<222>  (82)..(82)
<223>  n is unlocked nucleomonomer UNA-C

<220>
<221>  misc_feature
<222>  (83)..(84)
<223>  n is unlocked nucleomonomer UNA-U

<220>
<221>  misc_feature
<222>  (85)..(85)
<223>  n is unlocked nucleomonomer UNA-A

<220>
<221>  misc_feature
<222>  (86)..(86)
<223>  n is unlocked nucleomonomer UNA-C

<220>
<221>  misc_feature
<222>  (87)..(87)
<223>  n is unlocked nucleomonomer UNA-A

<220>
<221>  misc_feature
<222>  (88)..(88)
<223>  n is unlocked nucleomonomer UNA-C

<220>
<221>  misc_feature
<222>  (89)..(90)
<223>  n is unlocked nucleomonomer UNA-U

<220>
<221>  misc_feature
<222>  (91)..(91)
<223>  n is unlocked nucleomonomer UNA-A

<220>
<221>  misc_feature
<222>  (92)..(92)
<223>  n is unlocked nucleomonomer UNA-C

<220>
<221>  misc_feature
<222>  (93)..(96)
<223>  n is unlocked nucleomonomer UNA-A

<220>
<221>  misc_feature
<222>  (97)..(97)
<223>  n is unlocked nucleomonomer UNA-U

<220>
<221>  misc_feature
<222>  (98)..(98)
<223>  n is unlocked nucleomonomer UNA-G

<220>
<221>  misc_feature
<222>  (99)..(100)
<223>  n is unlocked nucleomonomer UNA-U

<220>
<221>  misc_feature
<222>  (101)..(101)
<223>  n is unlocked nucleomonomer UNA-G

<220>
<221>  misc_feature
<222>  (102)..(102)
<223>  n is unlocked nucleomonomer UNA-U

<220>
<221>  misc_feature
<222>  (103)..(107)
<223>  n is unlocked nucleomonomer UNA-C

<220>
<221>  misc_feature
<222>  (108)..(111)
<223>  n is unlocked nucleomonomer UNA-A

<220>
<221>  misc_feature
<222>  (112)..(112)
<223>  n is unlocked nucleomonomer UNA-U

<220>
<221>  misc_feature
<222>  (113)..(113)
<223>  n is unlocked nucleomonomer UNA-G

<220>
<221>  misc_feature
<222>  (114)..(114)
<223>  n is unlocked nucleomonomer UNA-U

<220>
<221>  misc_feature
<222>  (115)..(115)
<223>  n is unlocked nucleomonomer UNA-A

<220>
<221>  misc_feature
<222>  (116)..(116)
<223>  n is unlocked nucleomonomer UNA-G

<220>
<221>  misc_feature
<222>  (117)..(118)
<223>  n is unlocked nucleomonomer UNA-C

<220>
<221>  misc_feature
<222>  (119)..(119)
<223>  n is unlocked nucleomonomer UNA-A

<220>
<221>  misc_feature
<222>  (120)..(121)
<223>  n is unlocked nucleomonomer UNA-U

<220>
<221>  misc_feature
<222>  (122)..(122)
<223>  n is unlocked nucleomonomer UNA-C

<220>
<221>  misc_feature
<222>  (123)..(123)
<223>  n is unlocked nucleomonomer UNA-G

<220>
<221>  misc_feature
<222>  (124)..(124)
<223>  n is unlocked nucleomonomer UNA-U

<220>
<221>  misc_feature
<222>  (125)..(125)
<223>  n is unlocked nucleomonomer UNA-A

<220>
<221>  misc_feature
<222>  (126)..(126)
<223>  n is unlocked nucleomonomer UNA-U

<220>
<221>  misc_feature
<222>  (127)..(127)
<223>  n is unlocked nucleomonomer UNA-C

<220>
<221>  misc_feature
<222>  (128)..(128)
<223>  n is unlocked nucleomonomer UNA-U

<220>
<221>  misc_feature
<222>  (129)..(129)
<223>  n is unlocked nucleomonomer UNA-G

<220>
<221>  misc_feature
<222>  (130)..(130)
<223>  n is unlocked nucleomonomer UNA-C

<220>
<221>  misc_feature
<222>  (131)..(131)
<223>  n is unlocked nucleomonomer UNA-U

<220>
<221>  misc_feature
<222>  (132)..(133)
<223>  n is unlocked nucleomonomer UNA-C

<220>
<221>  misc_feature
<222>  (134)..(134)
<223>  n is unlocked nucleomonomer UNA-U

<220>
<221>  misc_feature
<222>  (135)..(136)
<223>  n is unlocked nucleomonomer UNA-A

<220>
<221>  misc_feature
<222>  (137)..(137)
<223>  n is unlocked nucleomonomer UNA-U

<220>
<221>  misc_feature
<222>  (138)..(142)
<223>  n is unlocked nucleomonomer UNA-A

<220>
<221>  misc_feature
<222>  (143)..(143)
<223>  n is unlocked nucleomonomer UNA-G

<220>
<221>  misc_feature
<222>  (144)..(146)
<223>  n is unlocked nucleomonomer UNA-A

<220>
<221>  misc_feature
<222>  (147)..(147)
<223>  n is unlocked nucleomonomer UNA-G

<220>
<221>  misc_feature
<222>  (148)..(149)
<223>  n is unlocked nucleomonomer UNA-U

<220>
<221>  misc_feature
<222>  (150)..(150)
<223>  n is unlocked nucleomonomer UNA-U

<220>
<221>  misc_feature
<222>  (151)..(151)
<223>  n is unlocked nucleomonomer UNA-C

<220>
<221>  misc_feature
<222>  (152)..(153)
<223>  n is unlocked nucleomonomer UNA-U

<220>
<221>  misc_feature
<222>  (154)..(154)
<223>  n is unlocked nucleomonomer UNA-C

<220>
<221>  misc_feature
<222>  (155)..(155)
<223>  n is unlocked nucleomonomer UNA-A

<220>
<221>  misc_feature
<222>  (156)..(156)
<223>  n is unlocked nucleomonomer UNA-C

<220>
<221>  misc_feature
<222>  (157)..(157)
<223>  n is unlocked nucleomonomer UNA-A

<220>
<221>  misc_feature
<222>  (158)..(158)
<223>  n is unlocked nucleomonomer UNA-U

<400>  37
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn       60

nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn      120

nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnn                              158


<210>  38
<211>  100
<212>  RNA
<213>  Unknown

<220>
<223>  Poly(A) 100 Tail

<400>  38
aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa       60

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa                            100


<210>  39
<211>  110
<212>  RNA
<213>  Unknown

<220>
<223>  Poly(A) 110 Tail

<400>  39
aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa       60

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa                 110


<210>  40
<211>  9
<212>  RNA
<213>  Unknown

<220>
<223>  Triple Stop Codon

<400>  40
auaagugaa                                                                9


<210>  41
<211>  4599
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Codon-Optimized AGL Coding Sequence

<400>  41
augggccaca gcaagcagau ccggauccug cugcugaacg agauggagaa gcuggagaag       60

acccuguucc ggcuggagca gggcuacgag cugcaguucc ggcugggccc cacccugcag      120

ggcaaggccg ugaccgugua caccaacuac cccuuccccg gcgagaccuu caaccgggag      180

aaguuccgga gccuggacug ggagaacccc accgagcggg aggacgacag cgacaaguac      240

ugcaagcuga accugcagca gagcggcagc uuccaguacu acuuccugca gggcaacgag      300

aagagcggcg gcggcuacau cgugguggac cccauccugc gggugggcgc cgacaaccac      360

gugcugcccc uggacugcgu gacccugcag accuuccugg ccaagugccu gggccccuuc      420

gacgaguggg agagccggcu gcggguggcc aaggagagcg gcuacaacau gauccacuuc      480

accccccugc agacccuggg ccugagccgg agcugcuaca gccuggccaa ccagcuggag      540

cugaaccccg acuucagccg gcccaaccgg aaguacaccu ggaacgacgu gggccagcug      600

guggagaagc ugaagaagga guggaacgug aucugcauca ccgacguggu guacaaccac      660

accgccgcca acagcaagug gauccaggag caccccgagu gcgccuacaa ccuggugaac      720

agcccccacc ugaagcccgc cugggugcug gaccgggccc uguggcgguu cagcugcgac      780

guggccgagg gcaaguacaa ggagaagggc auccccgccc ugaucgagaa cgaccaccac      840

augaacagca uccggaagau caucugggag gacaucuucc ccaagcugaa gcugugggag      900

uucuuccagg uggacgugaa caaggccgug gagcaguucc ggcggcugcu gacccaggag      960

aaccggcggg ugaccaagag cgaccccaac cagcaccuga ccaucaucca ggaccccgag     1020

uaccggcggu ucggcugcac cguggacaug aacaucgccc ugaccaccuu caucccccac     1080

gacaagggcc ccgccgccau cgaggagugc ugcaacuggu uccacaagcg gauggaggag     1140

cugaacagcg agaagcaccg gcugaucaac uaccaccagg agcaggccgu gaacugccug     1200

cugggcaacg uguucuacga gcggcuggcc ggccacggcc ccaagcuggg ccccgugacc     1260

cggaagcacc cccuggugac ccgguacuuc accuuccccu ucgaggagau cgacuucagc     1320

auggaggaga gcaugaucca ccugcccaac aaggccugcu uccugauggc ccacaacggc     1380

ugggugaugg gcgacgaccc ccugcggaac uucgccgagc ccggcagcga gguguaccug     1440

cggcgggagc ugaucugcug gggcgacagc gugaagcugc gguacggcaa caagcccgag     1500

gacugccccu accugugggc ccacaugaag aaguacaccg agaucaccgc caccuacuuc     1560

cagggcgugc ggcuggacaa cugccacagc accccccugc acguggccga guacaugcug     1620

gacgccgccc ggaaccugca gcccaaccug uacguggugg ccgagcuguu caccggcagc     1680

gaggaccugg acaacguguu cgugacccgg cugggcauca gcagccugau ccgggaggcc     1740

augagcgccu acaacagcca cgaggagggc cggcuggugu accgguacgg cggcgagccc     1800

gugggcagcu ucgugcagcc cugccugcgg ccccugaugc ccgccaucgc ccacgcccug     1860

uucauggaca ucacccacga caacgagugc cccaucgugc accggagcgc cuacgacgcc     1920

cugcccagca ccaccaucgu gagcauggcc ugcugcgcca gcggcagcac ccggggcuac     1980

gacgagcugg ugccccacca gaucagcgug gugagcgagg agcgguucua caccaagugg     2040

aaccccgagg cccugcccag caacaccggc gaggugaacu uccagagcgg caucaucgcc     2100

gcccggugcg ccaucagcaa gcugcaccag gagcugggcg ccaagggcuu cauccaggug     2160

uacguggacc agguggacga ggacaucgug gccgugaccc ggcacagccc cagcauccac     2220

cagagcgugg uggccgugag ccggaccgcc uuccggaacc ccaagaccag cuucuacagc     2280

aaggaggugc cccagaugug cauccccggc aagaucgagg agguggugcu ggaggcccgg     2340

accaucgagc ggaacaccaa gcccuaccgg aaggacgaga acagcaucaa cggcaccccc     2400

gacaucaccg uggagauccg ggagcacauc cagcugaacg agagcaagau cgugaagcag     2460

gccggcgugg ccaccaaggg ccccaacgag uacauccagg agaucgaguu cgagaaccug     2520

agccccggca gcgugaucau cuuccgggug agccuggacc cccacgccca gguggccgug     2580

ggcauccugc ggaaccaccu gacccaguuc agcccccacu ucaagagcgg cagccuggcc     2640

guggacaacg ccgaccccau ccugaagauc cccuucgcca gccuggccag ccggcugacc     2700

cuggccgagc ugaaccagau ccuguaccgg ugcgagagcg aggagaagga ggacggcggc     2760

ggcugcuacg acauccccaa cuggagcgcc cugaaguacg ccggccugca gggccugaug     2820

agcgugcugg ccgagauccg gcccaagaac gaccugggcc accccuucug caacaaccug     2880

cggagcggcg acuggaugau cgacuacgug agcaaccggc ugaucagccg gagcggcacc     2940

aucgccgagg ugggcaagug gcugcaggcc auguucuucu accugaagca gaucccccgg     3000

uaccugaucc ccugcuacuu cgacgccauc cugaucggcg ccuacaccac ccugcuggac     3060

accgccugga agcagaugag cagcuucgug cagaacggca gcaccuucgu gaagcaccug     3120

agccugggca gcgugcagcu gugcggcgug ggcaaguucc ccagccugcc cauccugagc     3180

cccgcccuga uggacgugcc cuaccggcug aacgagauca ccaaggagaa ggagcagugc     3240

ugcgugagcc uggccgccgg ccugccccac uucagcagcg gcaucuuccg gugcuggggc     3300

cgggacaccu ucaucgcccu gcggggcauc cugcugauca ccggccggua cguggaggcc     3360

cggaacauca uccuggccuu cgccggcacc cugcggcacg gccugauccc caaccugcug     3420

ggcgagggca ucuacgcccg guacaacugc cgggacgccg ugugguggug gcugcagugc     3480

auccaggacu acugcaagau ggugcccaac ggccuggaca uccugaagug ccccgugagc     3540

cggauguacc ccaccgacga cagcgccccc cugcccgccg gcacccugga ccagccccug     3600

uucgagguga uccaggaggc caugcagaag cacaugcagg gcauccaguu ccgggagcgg     3660

aacgccggcc cccagaucga ccggaacaug aaggacgagg gcuucaacau caccgccggc     3720

guggacgagg agaccggcuu cguguacggc ggcaaccggu ucaacugcgg caccuggaug     3780

gacaagaugg gcgagagcga ccgggcccgg aaccggggca uccccgccac cccccgggac     3840

ggcagcgccg uggagaucgu gggccugagc aagagcgccg ugcgguggcu gcuggagcug     3900

agcaagaaga acaucuuccc cuaccacgag gugaccguga agcggcacgg caaggccauc     3960

aaggugagcu acgacgagug gaaccggaag auccaggaca acuucgagaa gcuguuccac     4020

gugagcgagg accccagcga ccugaacgag aagcacccca accuggugca caagcggggc     4080

aucuacaagg acagcuacgg cgccagcagc cccuggugcg acuaccagcu gcggcccaac     4140

uucaccaucg ccaugguggu ggcccccgag cuguucacca ccgagaaggc cuggaaggcc     4200

cuggagaucg ccgagaagaa gcugcugggc ccccugggca ugaagacccu ggaccccgac     4260

gacauggugu acugcggcau cuacgacaac gcccuggaca acgacaacua caaccuggcc     4320

aagggcuuca acuaccacca gggccccgag uggcuguggc ccaucggcua cuuccugcgg     4380

gccaagcugu acuucagccg gcugaugggc cccgagacca ccgccaagac caucgugcug     4440

gugaagaacg ugcugagccg gcacuacgug caccuggagc ggagccccug gaagggccug     4500

cccgagcuga ccaacgagaa cgcccaguac ugccccuuca gcugcgagac ccaggccugg     4560

agcaucgcca ccauccugga gacccuguac gaccuguag                            4599


<210>  42
<211>  4599
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Codon-Optimized AGL Coding Sequence

<400>  42
augggccaua gcaagcagau ccggauccuc cugcucaaug agauggaaaa gcucgagaaa       60

acccucuuua ggcuggagca aggcuacgaa cuccaguuuc ggcucgggcc cacucuccag      120

ggcaaggccg ugaccgucua caccaacuau cccuucccug gcgagaccuu caacagggag      180

aaguuucggu cccucgacug ggagaacccc accgagaggg aggacgacuc cgacaaguau      240

ugcaagcuga accuccaaca auccgggucc uuccaguacu acuuucugca aggcaacgaa      300

aagagcgggg gcggguauau uguggucgau cccauccucc gggugggggc ugacaaccac      360

guccuccccc uggauugcgu gacucugcag accuuccucg cuaaaugccu gggcccuuuc      420

gacgaguggg agagcaggcu gcggguggcc aaggaguccg gguauaauau gauccacuuc      480

accccccugc agacucuggg ccucucccgg uccuguuaua gccuggccaa ccagcucgag      540

cucaacccug auuucuccag gccuaacagg aaauacaccu ggaacgacgu gggccagcuc      600

gucgagaagc ucaagaaaga guggaacgug aucugcauca cugacguggu cuauaaccac      660

acugcugcua acagcaagug gauucaggag caccccgagu gcgccuacaa ccuggucaac      720

uccccccauc ucaagccugc cuggguccuc gauagggccc uguggcgguu uagcugcgac      780

guggccgagg gcaaguauaa ggagaaaggc auuccugcuc ugaucgagaa cgaccaucac      840

augaacagca uucggaagau uaucugggaa gacaucuucc ccaaacugaa gcucugggag      900

uucuuucaag ucgacgucaa uaaggcugug gaacaauuca ggaggcugcu gacccaagag      960

aaccggcggg ucaccaaauc cgaccccaau caacaucuga cuaucaucca agacccugag     1020

uauaggcggu ucgggugcac ugucgacaug aauaucgccc ucacuacuuu uauuccccac     1080

gauaaaggcc ccgccgccau cgaggagugu ugcaacuggu uccacaagag gauggaagag     1140

cucaacuccg aaaaacaccg gcucaucaau uaccaccagg agcaggccgu gaacugucug     1200

cugggcaacg ucuucuacga gcggcucgcu gggcacgggc ccaagcucgg cccugucacu     1260

aggaaacacc cucucgugac ccgguacuuc acuuuucccu ucgaggaaau ugauuuuagc     1320

auggaggagu ccaugaucca ccuccccaac aaggcuugcu uccucauggc ccauaacggc     1380

ugggucaugg gcgacgaccc ucugcggaau uucgcugagc ccggguccga gguguaucuc     1440

cggagggagc ugaucuguug gggcgauagc gugaagcucc gguacggcaa caagcccgaa     1500

gauugcccuu accucugggc ccauaugaag aaguauacug agauuacugc cacuuacuuu     1560

cagggcgucc ggcuggacaa uugucauucc accccucugc augucgcuga auauaugcug     1620

gacgcugcuc ggaaccugca acccaaccuc uacgucgucg cugagcucuu uaccggcagc     1680

gaggaccucg auaacgucuu cgugacuagg cucgggauca gcagccucau uagggaagcc     1740

augagcgccu acaacagcca cgaggaaggg aggcucgugu aucgguacgg cggcgagccu     1800

gugggcagcu ucgugcagcc cugccugcgg ccucucaugc ccgcuaucgc ccacgcccuc     1860

uucauggaca ucacucacga caacgaaugc ccuaucgucc acagguccgc uuacgacgcu     1920

cugcccagca cuaccaucgu guccauggcc ugcugcgcua gcggcagcac caggggguac     1980

gacgagcucg ucccucacca gaucuccguc guguccgagg agcgguucua uacuaaaugg     2040

aacccugagg cccugccuuc caauaccggg gaggugaacu uucaaagcgg gaucaucgcc     2100

gcccggugcg cuauuagcaa gcugcaccag gaacugggcg ccaaaggguu cauccagguc     2160

uacgucgacc aaguggacga ggauauuguc gccgucacca ggcauucccc uagcauucac     2220

caguccgugg ucgcugucuc caggacugcu uuucggaacc ccaaaacuuc cuucuauagc     2280

aaagaggucc cucaaaugug uauuccuggg aagaucgagg aggucgugcu ggaggcuagg     2340

acuaucgaaa ggaauacuaa gccuuaccgg aaagacgaaa acuccauuaa cggcaccccc     2400

gacauuaccg ucgagaucag ggagcacauc cagcugaacg agagcaagau cgugaagcaa     2460

gcuggcgugg ccaccaaggg ccccaacgag uacauccaag agauugaguu cgagaaucug     2520

ucccccggca gcgugaucau uuuuagggug agccuggacc cccacgccca agucgcugug     2580

ggcauccugc ggaaccaccu cacccaauuu agcccucauu ucaaguccgg gagccucgcu     2640

guggauaacg ccgacccuau ucucaagauc ccuuucgcuu cccuggccag caggcucacu     2700

cuggcugaac ucaaccagau ucuguaucgg ugcgaguccg aggagaaaga ggacgggggc     2760

ggcuguuacg auauucccaa uugguccgcc cugaaguacg ccgggcugca agggcucaug     2820

uccguccugg ccgagauuag gcccaaaaac gaucugggcc acccuuucug caacaaccug     2880

agguccggcg acuggaugau cgauuacguc agcaaucggc ugaucucccg guccggcacu     2940

aucgcugagg uggggaagug gcugcaggcu auguuuuuuu aucucaaaca gauuccccgg     3000

uaucugauuc ccugcuauuu cgacgcuauu cucaucgggg ccuacaccac ucugcucgac     3060

accgccugga aacagauguc cagcuucgug cagaacgggu ccaccuucgu caagcaucug     3120

ucccuggggu ccgugcaacu cugcggcguc ggcaaguuuc cuagccuccc cauccugucc     3180

ccugcccuca uggacguccc uuaccggcuc aacgaaauua ccaaggagaa agaacaaugc     3240

ugcguguccc ucgcugccgg gcucccucac uucuccuccg ggaucuuucg guguuggggc     3300

cgggacacuu ucaucgcccu gagggggauu cuccucauca cuggccggua cgucgaggcc     3360

cggaacauca uccucgccuu cgcugggacc cuccggcacg ggcucauccc uaaccuccuc     3420

ggggagggca ucuacgccag guauaacugc cgggacgcug ucugguggug gcuccagugc     3480

auucaggacu auugcaagau ggugcccaac gggcucgaua uccucaaaug ucccgugagc     3540

aggauguacc cuaccgacga cuccgcuccu cugccugcug ggacccucga ccagccccug     3600

uucgagguca uucaggaggc caugcaaaag cauaugcagg ggauucaguu ucgggagcgg     3660

aacgcugggc cccagauuga ccggaauaug aaagaugagg gguucaacau uacugccggc     3720

guggacgagg agaccggcuu cguguacggc ggcaaccggu uuaacugcgg gaccuggaug     3780

gacaagaugg gcgagagcga uagggcuagg aauaggggca uucccgccac ccccagggac     3840

ggcuccgcug ucgagaucgu cgggcucagc aaguccgcug ugcgguggcu gcucgagcuc     3900

agcaagaaga acaucuuucc uuaccacgag gucaccguca agaggcacgg caaagcuauu     3960

aaagucuccu acgacgaaug gaauaggaag auucaagaua auuucgagaa acucuuccac     4020

gugagcgagg auccuuccga ccucaacgag aaacacccca accucgugca uaagcggggg     4080

auuuauaagg acagcuacgg cgcuuccagc ccuuggugcg auuaccagcu ccggccuaac     4140

uucaccauug ccaugguggu cgccccugaa cucuucacua ccgagaaggc cuggaaggcu     4200

cuggaaaucg ccgagaagaa gcugcugggg ccccugggga ugaagacucu cgaccccgac     4260

gacauggugu auugcggcau cuacgauaac gcccucgaua acgauaauua uaaccuggcu     4320

aagggguuua acuaccauca aggcccugaa uggcucuggc cuaucggcua cuuccugcgg     4380

gccaagcucu acuucagcag gcugaugggg cccgaaacua cugccaaaac uauugugcug     4440

gugaagaacg ugcugagccg gcacuacgug caccuggaaa ggagcccuug gaagggccug     4500

cccgagcuca ccaacgaaaa cgcccaguau ugcccuuuua gcugcgagac ccaagccugg     4560

uccaucgcua cuauccugga aacccuguac gaccucuag                            4599


<210>  43
<211>  4599
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Codon-Optimized AGL Coding Sequence

<400>  43
auggggcaca gcaaacaaau caggauccuc cuccucaacg aaauggaaaa acucgaaaaa       60

acccucuuca ggcucgaaca aggguacgaa cuccaauuca ggcucgggcc gacgcuccaa      120

gggaaagcgg ugacggugua cacgaacuac ccguucccgg gggaaacguu caacagggaa      180

aaauucagga gccucgacug ggaaaacccg acggaaaggg aagacgacag cgacaaauac      240

ugcaaacuca accuccaaca aagcgggagc uuccaauacu acuuccucca agggaacgaa      300

aaaagcgggg ggggguacau cgugguggac ccgauccuca gggugggggc ggacaaccac      360

gugcucccgc ucgacugcgu gacgcuccaa acguuccucg cgaaaugccu cgggccguuc      420

gacgaauggg aaagcaggcu caggguggcg aaagaaagcg gguacaacau gauccacuuc      480

acgccgcucc aaacgcucgg gcucagcagg agcugcuaca gccucgcgaa ccaacucgaa      540

cucaacccgg acuucagcag gccgaacagg aaauacacgu ggaacgacgu ggggcaacuc      600

guggaaaaac ucaaaaaaga auggaacgug aucugcauca cggacguggu guacaaccac      660

acggcggcga acagcaaaug gauccaagaa cacccggaau gcgcguacaa ccucgugaac      720

agcccgcacc ucaaaccggc gugggugcuc gacagggcgc ucuggagguu cagcugcgac      780

guggcggaag ggaaauacaa agaaaaaggg aucccggcgc ucaucgaaaa cgaccaccac      840

augaacagca ucaggaaaau caucugggaa gacaucuucc cgaaacucaa acucugggaa      900

uucuuccaag uggacgugaa caaagcggug gaacaauuca ggaggcuccu cacgcaagaa      960

aacaggaggg ugacgaaaag cgacccgaac caacaccuca cgaucaucca agacccggaa     1020

uacaggaggu ucgggugcac gguggacaug aacaucgcgc ucacgacguu caucccgcac     1080

gacaaagggc cggcggcgau cgaagaaugc ugcaacuggu uccacaaaag gauggaagaa     1140

cucaacagcg aaaaacacag gcucaucaac uaccaccaag aacaagcggu gaacugccuc     1200

cucgggaacg uguucuacga aaggcucgcg gggcacgggc cgaaacucgg gccggugacg     1260

aggaaacacc cgcucgugac gagguacuuc acguucccgu ucgaagaaau cgacuucagc     1320

auggaagaaa gcaugaucca ccucccgaac aaagcgugcu uccucauggc gcacaacggg     1380

ugggugaugg gggacgaccc gcucaggaac uucgcggaac cggggagcga aguguaccuc     1440

aggagggaac ucaucugcug gggggacagc gugaaacuca gguacgggaa caaaccggaa     1500

gacugcccgu accucugggc gcacaugaaa aaauacacgg aaaucacggc gacguacuuc     1560

caagggguga ggcucgacaa cugccacagc acgccgcucc acguggcgga auacaugcuc     1620

gacgcggcga ggaaccucca accgaaccuc uacguggugg cggaacucuu cacggggagc     1680

gaagaccucg acaacguguu cgugacgagg cucgggauca gcagccucau cagggaagcg     1740

augagcgcgu acaacagcca cgaagaaggg aggcucgugu acagguacgg gggggaaccg     1800

guggggagcu ucgugcaacc gugccucagg ccgcucaugc cggcgaucgc gcacgcgcug     1860

uucauggaca ucacgcacga caacgaaugc ccgaucgugc acaggagcgc guacgacgcg     1920

cucccgagca cgacgaucgu gagcauggcg ugcugcgcga gcgggagcac gaggggguac     1980

gacgaacucg ugccgcacca aaucagcgug gugagcgaag aaagguucua cacgaaaugg     2040

aacccggaag cgcucccgag caacacgggg gaagugaacu uccaaagcgg gaucaucgcg     2100

gcgaggugcg cgaucagcaa acuccaccaa gaacucgggg cgaaaggguu cauccaagug     2160

uacguggacc aaguggacga agacaucgug gcggugacga ggcacagccc gagcauccac     2220

caaagcgugg uggcggugag caggacggcg uucaggaacc cgaaaacgag cuucuacagc     2280

aaagaagugc cgcaaaugug caucccgggg aaaaucgaag aaguggugcu cgaagcgagg     2340

acgaucgaaa ggaacacgaa accguacagg aaagacgaaa acagcaucaa cgggacgccg     2400

gacaucacgg uggaaaucag ggaacacauc caacucaacg aaagcaaaau cgugaaacaa     2460

gcgggggugg cgacgaaagg gccgaacgaa uacauccaag aaaucgaauu cgaaaaccuc     2520

agcccgggga gcgugaucau cuucagggug agccucgacc cgcacgcgca aguggcggug     2580

gggauccuca ggaaccaccu cacgcaauuc agcccgcacu ucaaaagcgg gagccucgcg     2640

guggacaacg cggacccgau ccucaaaauc ccguucgcga gccucgcgag caggcucacg     2700

cucgcggaac ucaaccaaau ccucuacagg ugcgaaagcg aagaaaaaga agacgggggg     2760

gggugcuacg acaucccgaa cuggagcgcg cucaaauacg cggggcucca agggcucaug     2820

agcgugcucg cggaaaucag gccgaaaaac gaccucgggc acccguucug caacaaccuc     2880

aggagcgggg acuggaugau cgacuacgug agcaacaggc ucaucagcag gagcgggacg     2940

aucgcggaag uggggaaaug gcuccaagcg auguucuucu accucaaaca aaucccgagg     3000

uaccucaucc cgugcuacuu cgacgcgauc cucaucgggg cguacacgac gcuccucgac     3060

acggcgugga aacaaaugag cagcuucgug caaaacggga gcacguucgu gaaacaccuc     3120

agccucggga gcgugcaacu cugcggggug gggaaauucc cgagccuccc gauccucagc     3180

ccggcgcuca uggacgugcc guacaggcuc aacgaaauca cgaaagaaaa agaacaaugc     3240

ugcgugagcc ucgcggcggg gcucccgcac uucagcagcg ggaucuucag gugcuggggg     3300

agggacacgu ucaucgcgcu cagggggauc cuccucauca cggggaggua cguggaagcg     3360

aggaacauca uccucgcguu cgcggggacg cucaggcacg ggcucauccc gaaccuccuc     3420

ggggaaggga ucuacgcgag guacaacugc agggacgcgg ugugguggug gcuccaaugc     3480

auccaagacu acugcaaaau ggugccgaac gggcucgaca uccucaaaug cccggugagc     3540

aggauguacc cgacggacga cagcgcgccg cucccggcgg ggacgcucga ccaaccgcug     3600

uucgaaguga uccaagaagc gaugcaaaaa cacaugcaag ggauccaauu cagggaaagg     3660

aacgcggggc cgcaaaucga caggaacaug aaagacgaag gguucaacau cacggcgggg     3720

guggacgaag aaacgggguu cguguacggg gggaacaggu ucaacugcgg gacguggaug     3780

gacaaaaugg gggaaagcga cagggcgagg aacaggggga ucccggcgac gccgagggac     3840

gggagcgcgg uggaaaucgu ggggcucagc aaaagcgcgg ugagguggcu ccucgaacuc     3900

agcaaaaaaa acaucuuccc guaccacgaa gugacgguga aaaggcacgg gaaagcgauc     3960

aaagugagcu acgacgaaug gaacaggaaa auccaagaca acuucgaaaa acucuuccac     4020

gugagcgaag acccgagcga ccucaacgaa aaacacccga accucgugca caaaaggggg     4080

aucuacaaag acagcuacgg ggcgagcagc ccguggugcg acuaccaacu caggccgaac     4140

uucacgaucg cgaugguggu ggcgccggaa cucuucacga cggaaaaagc guggaaagcg     4200

cucgaaaucg cggaaaaaaa acuccucggg ccgcucggga ugaaaacgcu cgacccggac     4260

gacauggugu acugcgggau cuacgacaac gcgcucgaca acgacaacua caaccucgcg     4320

aaaggguuca acuaccacca agggccggaa uggcucuggc cgaucgggua cuuccucagg     4380

gcgaaacucu acuucagcag gcucaugggg ccggaaacga cggcgaaaac gaucgugcuc     4440

gugaaaaacg ugcucagcag gcacuacgug caccucgaaa ggagcccgug gaaagggcuc     4500

ccggaacuca cgaacgaaaa cgcgcaauac ugcccguuca gcugcgaaac gcaagcgugg     4560

agcaucgcga cgauccucga aacgcucuac gaccucuga                            4599


<210>  44
<211>  4599
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Codon-Optimized AGL Coding Sequence

<400>  44
augggccaca gcaagcagau caggauccuc cuccucaacg aaauggaaaa gcucgaaaag       60

acacucuuca ggcucgaaca gggcuacgaa cuccaguuca ggcucggccc aacacuccag      120

ggcaaggccg ugacagugua cacaaacuac ccauucccag gcgaaacauu caacagggaa      180

aaguucagga gccucgacug ggaaaaccca acagaaaggg aagacgacag cgacaaguac      240

ugcaagcuca accuccagca gagcggcagc uuccaguacu acuuccucca gggcaacgaa      300

aagagcggcg gcggcuacau cgugguggac ccaauccuca gggugggcgc cgacaaccac      360

gugcucccac ucgacugcgu gacacuccag acauuccucg ccaagugccu cggcccauuc      420

gacgaauggg aaagcaggcu caggguggcc aaggaaagcg gcuacaacau gauccacuuc      480

acaccacucc agacacucgg ccucagcagg agcugcuaca gccucgccaa ccagcucgaa      540

cucaacccag acuucagcag gccaaacagg aaguacacau ggaacgacgu gggccagcuc      600

guggaaaagc ucaagaagga auggaacgug aucugcauca cagacguggu guacaaccac      660

acagccgcca acagcaagug gauccaggaa cacccagaau gcgccuacaa ccucgugaac      720

agcccacacc ucaagccagc cugggugcuc gacagggccc ucuggagguu cagcugcgac      780

guggccgaag gcaaguacaa ggaaaagggc aucccagccc ucaucgaaaa cgaccaccac      840

augaacagca ucaggaagau caucugggaa gacaucuucc caaagcucaa gcucugggaa      900

uucuuccagg uggacgugaa caaggccgug gaacaguuca ggaggcuccu cacacaggaa      960

aacaggaggg ugacaaagag cgacccaaac cagcaccuca caaucaucca ggacccagaa     1020

uacaggaggu ucggcugcac aguggacaug aacaucgccc ucacaacauu caucccacac     1080

gacaagggcc cagccgccau cgaagaaugc ugcaacuggu uccacaagag gauggaagaa     1140

cucaacagcg aaaagcacag gcucaucaac uaccaccagg aacaggccgu gaacugccuc     1200

cucggcaacg uguucuacga aaggcucgcc ggccacggcc caaagcucgg cccagugaca     1260

aggaagcacc cacucgugac aagguacuuc acauucccau ucgaagaaau cgacuucagc     1320

auggaagaaa gcaugaucca ccucccaaac aaggccugcu uccucauggc ccacaacggc     1380

ugggugaugg gcgacgaccc acucaggaac uucgccgaac caggcagcga aguguaccuc     1440

aggagggaac ucaucugcug gggcgacagc gugaagcuca gguacggcaa caagccagaa     1500

gacugcccau accucugggc ccacaugaag aaguacacag aaaucacagc cacauacuuc     1560

cagggcguga ggcucgacaa cugccacagc acaccacucc acguggccga auacaugcuc     1620

gacgccgcca ggaaccucca gccaaaccuc uacguggugg ccgaacucuu cacaggcagc     1680

gaagaccucg acaacguguu cgugacaagg cucggcauca gcagccucau cagggaagcc     1740

augagcgccu acaacagcca cgaagaaggc aggcucgugu acagguacgg cggcgaacca     1800

gugggcagcu ucgugcagcc augccucagg ccacucaugc cagccaucgc ccacgcccuc     1860

uucauggaca ucacacacga caacgaaugc ccaaucgugc acaggagcgc cuacgacgcc     1920

cucccaagca caacaaucgu gagcauggcc ugcugcgcca gcggcagcac aaggggcuac     1980

gacgaacucg ugccacacca gaucagcgug gugagcgaag aaagguucua cacaaagugg     2040

aacccagaag cccucccaag caacacaggc gaagugaacu uccagagcgg caucaucgcc     2100

gccaggugcg ccaucagcaa gcuccaccag gaacucggcg ccaagggcuu cauccaggug     2160

uacguggacc agguggacga agacaucgug gccgugacaa ggcacagccc aagcauccac     2220

cagagcgugg uggccgugag caggacagcc uucaggaacc caaagacaag cuucuacagc     2280

aaggaagugc cacagaugug caucccaggc aagaucgaag aaguggugcu cgaagccagg     2340

acaaucgaaa ggaacacaaa gccauacagg aaggacgaaa acagcaucaa cggcacacca     2400

gacaucacag uggaaaucag ggaacacauc cagcucaacg aaagcaagau cgugaagcag     2460

gccggcgugg ccacaaaggg cccaaacgaa uacauccagg aaaucgaauu cgaaaaccuc     2520

agcccaggca gcgugaucau cuucagggug agccucgacc cacacgccca gguggccgug     2580

ggcauccuca ggaaccaccu cacacaguuc agcccacacu ucaagagcgg cagccucgcc     2640

guggacaacg ccgacccaau ccucaagauc ccauucgcca gccucgccag caggcucaca     2700

cucgccgaac ucaaccagau ccucuacagg ugcgaaagcg aagaaaagga agacggcggc     2760

ggcugcuacg acaucccaaa cuggagcgcc cucaaguacg ccggccucca gggccucaug     2820

agcgugcucg ccgaaaucag gccaaagaac gaccucggcc acccauucug caacaaccuc     2880

aggagcggcg acuggaugau cgacuacgug agcaacaggc ucaucagcag gagcggcaca     2940

aucgccgaag ugggcaagug gcuccaggcc auguucuucu accucaagca gaucccaagg     3000

uaccucaucc caugcuacuu cgacgccauc cucaucggcg ccuacacaac acuccucgac     3060

acagccugga agcagaugag cagcuucgug cagaacggca gcacauucgu gaagcaccuc     3120

agccucggca gcgugcagcu cugcggcgug ggcaaguucc caagccuccc aauccucagc     3180

ccagcccuca uggacgugcc auacaggcuc aacgaaauca caaaggaaaa ggaacagugc     3240

ugcgugagcc ucgccgccgg ccucccacac uucagcagcg gcaucuucag gugcuggggc     3300

agggacacau ucaucgcccu caggggcauc cuccucauca caggcaggua cguggaagcc     3360

aggaacauca uccucgccuu cgccggcaca cucaggcacg gccucauccc aaaccuccuc     3420

ggcgaaggca ucuacgccag guacaacugc agggacgccg ugugguggug gcuccagugc     3480

auccaggacu acugcaagau ggugccaaac ggccucgaca uccucaagug cccagugagc     3540

aggauguacc caacagacga cagcgcccca cucccagccg gcacacucga ccagccacuc     3600

uucgaaguga uccaggaagc caugcagaag cacaugcagg gcauccaguu cagggaaagg     3660

aacgccggcc cacagaucga caggaacaug aaggacgaag gcuucaacau cacagccggc     3720

guggacgaag aaacaggcuu cguguacggc ggcaacaggu ucaacugcgg cacauggaug     3780

gacaagaugg gcgaaagcga cagggccagg aacaggggca ucccagccac accaagggac     3840

ggcagcgccg uggaaaucgu gggccucagc aagagcgccg ugagguggcu ccucgaacuc     3900

agcaagaaga acaucuuccc auaccacgaa gugacaguga agaggcacgg caaggccauc     3960

aaggugagcu acgacgaaug gaacaggaag auccaggaca acuucgaaaa gcuguuccac     4020

gugagcgaag acccaagcga ccucaacgaa aagcacccaa accucgugca caagaggggc     4080

aucuacaagg acagcuacgg cgccagcagc ccauggugcg acuaccagcu caggccaaac     4140

uucacaaucg ccaugguggu ggccccagaa cucuucacaa cagaaaaggc cuggaaggcc     4200

cucgaaaucg ccgaaaagaa gcuccucggc ccacucggca ugaagacacu cgacccagac     4260

gacauggugu acugcggcau cuacgacaac gcccucgaca acgacaacua caaccucgcc     4320

aagggcuuca acuaccacca gggcccagaa uggcucuggc caaucggcua cuuccucagg     4380

gccaagcucu acuucagcag gcucaugggc ccagaaacaa cagccaagac aaucgugcuc     4440

gugaagaacg ugcucagcag gcacuacgug caccucgaaa ggagcccaug gaagggccuc     4500

ccagaacuca caaacgaaaa cgcccaguac ugcccauuca gcugcgaaac acaggccugg     4560

agcaucgcca caauccucga aacacucuac gaccucuga                            4599


<210>  45
<211>  4599
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Codon-Optimized AGL Coding Sequence

<400>  45
augggccaca gcaagcagau ccggaucuug cugcugaacg agauggagaa gcuggagaag       60

acccuguuca ggcuggagca gggcuacgag cugcaguucc gguugggccc caccuugcag      120

ggcaaggccg ugaccgugua caccaacuac cccuuccccg gcgagacguu caacagggag      180

aaguuccggu cccuggacug ggagaacccc accgagaggg aggacgacuc cgacaaguac      240

ugcaagcuga accugcagca guccggcucc uuccaguacu acuuccugca gggcaacgag      300

aagaguggcg gcggcuacau cgugguggac cccaucuugc gggugggcgc cgacaaccac      360

gugcugcccu uggacugcgu gacccugcag accuucuugg ccaagugcuu gggccccuuc      420

gacgaguggg agagcaggcu gaggguggcc aaggaguccg gcuacaacau gauccacuuc      480

acccccuugc agacccuggg ccuguccagg uccugcuacu cccuggccaa ccaguuggag      540

uugaaccccg acuucuccag gcccaacagg aaguacaccu ggaacgacgu gggccagcug      600

guggagaagu ugaagaagga guggaacgug aucugcauca ccgacguggu guacaaccac      660

accgccgcca acagcaagug gauccaggag caccccgagu gcgccuacaa ccuggugaac      720

uccccccacu ugaagcccgc cuggguguug gacagggccc uguggcgguu cuccugcgac      780

guggccgagg gcaaguacaa ggagaagggc auccccgccu ugaucgagaa cgaccaccac      840

augaacucca uccggaagau caucugggag gacaucuucc ccaagcugaa gcugugggag      900

uucuuccagg uggacgugaa caaggccgug gagcaguuca ggaggcugcu gacccaggag      960

aacaggcggg ugaccaaguc cgaccccaac cagcaccuga ccaucaucca ggaccccgag     1020

uacaggcggu ucggcugcac cguggacaug aacaucgccc ugaccaccuu caucccccac     1080

gacaagggcc ccgccgccau cgaggagugc ugcaacuggu uccacaagag gauggaggag     1140

uugaacuccg agaagcaccg gcugaucaac uaccaccagg agcaggccgu gaacugccug     1200

uugggcaacg uguucuacga gcggcuggcc ggccacggcc ccaagcuggg ccccgugacc     1260

aggaagcacc ccuuggugac cagguacuuc accuuccccu ucgaggagau cgacuucucc     1320

auggaggagu ccaugaucca ccugcccaac aaggccugcu uccugauggc ccacaacggc     1380

ugggugaugg gcgacgaccc ccugcggaac uucgccgagc ccggcuccga gguguaccug     1440

aggagggagc ugaucugcug gggcgacagc gugaaguugc gguacggcaa caagcccgag     1500

gacugccccu accugugggc ccacaugaag aaguacaccg agaucaccgc caccuacuuc     1560

cagggcgugc ggcuggacaa cugccacucc accccccugc acguggccga guacauguug     1620

gacgccgcca ggaacuugca gcccaacuug uacguggugg ccgagcuguu caccggcagc     1680

gaggaccugg acaacguguu cgugaccagg cugggcauca gcuccuugau cagggaggcc     1740

augagcgccu acaacagcca cgaggagggc agguuggugu accgguacgg cggcgagccc     1800

gugggcuccu ucgugcagcc cugcuugagg cccuugaugc ccgccaucgc ccacgcccug     1860

uucauggaca ucacccacga caacgagugc cccaucgugc acagguccgc cuacgacgcc     1920

cugcccagca ccaccaucgu guccauggcc ugcugcgcca gcggcagcac caggggcuac     1980

gacgaguugg ugccccacca gaucuccgug guguccgagg agcgguucua caccaagugg     2040

aaccccgagg ccuugcccuc caacaccggc gaggugaacu uccagagcgg caucaucgcc     2100

gccaggugcg ccaucagcaa gcugcaccag gagcugggcg ccaagggcuu cauccaggug     2160

uacguggacc agguggacga ggacaucgug gccgugacca ggcacucccc cagcauccac     2220

caguccgugg uggccguguc caggaccgcc uucaggaacc ccaagaccuc cuucuacagc     2280

aaggaggugc cccagaugug cauccccggc aagaucgagg agguggugcu ggaggccagg     2340

accaucgaga ggaacaccaa gcccuacagg aaggacgaga acuccaucaa cggcaccccc     2400

gacaucaccg uggagaucag ggagcacauc cagcugaacg agagcaagau cgugaagcag     2460

gccggcgugg ccaccaaggg ccccaacgag uacauccagg agaucgaguu cgagaacuug     2520

ucccccggca gcgugaucau cuucagggug agccuggacc cccacgccca gguggccgug     2580

ggcauccugc ggaaccaccu gacccaguuc agcccccacu ucaaguccgg cagccuggcc     2640

guggacaacg ccgaccccau cuugaagauc cccuucgccu cccuggccuc cagguugacc     2700

uuggccgagc ugaaccagau ccuguaccgg ugcgaguccg aggagaagga ggacggcggc     2760

ggcugcuacg acauccccaa cugguccgcc cugaaguacg ccggccugca gggcuugaug     2820

uccguguugg ccgagaucag gcccaagaac gacuugggcc accccuucug caacaacuug     2880

agguccggcg acuggaugau cgacuacgug agcaaccggc ugaucucccg guccggcacc     2940

aucgccgagg ugggcaagug guugcaggcc auguucuucu accugaagca gaucccccgg     3000

uaccugaucc ccugcuacuu cgacgccauc uugaucggcg ccuacaccac ccugcuggac     3060

accgccugga agcagauguc cagcuucgug cagaacggcu ccaccuucgu gaagcaccug     3120

uccuugggcu ccgugcagcu gugcggcgug ggcaaguucc ccucccugcc cauccugucc     3180

cccgcccuga uggacgugcc cuacagguug aacgagauca ccaaggagaa ggagcagugc     3240

ugcguguccc uggccgccgg cuugccccac uucuccuccg gcaucuuccg gugcuggggc     3300

agggacaccu ucaucgcccu gaggggcauc cugcugauca ccggccggua cguggaggcc     3360

aggaacauca ucuuggccuu cgccggcacc cugaggcacg gccugauccc caaccugcug     3420

ggcgagggca ucuacgccag guacaacugc cgggacgccg ugugguggug gcugcagugc     3480

auccaggacu acugcaagau ggugcccaac ggccuggaca uccugaagug ccccgugucc     3540

aggauguacc ccaccgacga cuccgccccc uugcccgccg gcacccugga ccagcccuug     3600

uucgagguga uccaggaggc caugcagaag cacaugcagg gcauccaguu ccgggagagg     3660

aacgccggcc cccagaucga ccggaacaug aaggacgagg gcuucaacau caccgccggc     3720

guggacgagg agacuggcuu cguguacggc ggcaaccggu ucaacugcgg caccuggaug     3780

gacaagaugg gcgagagcga cagggccagg aacaggggca uccccgccac ccccagggac     3840

ggcuccgccg uggagaucgu gggccugagc aaguccgccg ugcggugguu gcuggaguug     3900

uccaagaaga acaucuuccc cuaccacgag gugaccguga agaggcacgg caaggccauc     3960

aagguguccu acgacgagug gaacaggaag auccaggaca acuucgagaa gcuguuccac     4020

guguccgagg accccuccga cuugaacgag aagcacccca accuggugca caagcggggc     4080

aucuacaagg acagcuacgg cgccuccagc cccuggugcg acuaccagcu gaggcccaac     4140

uucaccaucg ccaugguggu ggcccccgag cuguucacca ccgagaaggc cuggaaggcc     4200

uuggagaucg ccgagaagaa guugcugggc ccccugggca ugaagaccuu ggaccccgac     4260

gacauggugu acugcggcau cuacgacaac gccuuggaca acgacaacua caaccuggcc     4320

aagggcuuca acuaccacca gggccccgag uggcuguggc ccaucggcua cuuccugcgg     4380

gccaaguugu acuucuccag guugaugggc cccgagacga ccgccaagac caucguguug     4440

gugaagaacg ugcugucccg gcacuacgug caccuggaga ggucccccug gaagggccug     4500

cccgagcuga ccaacgagaa cgcccaguac ugccccuuca gcugcgagac gcaggccugg     4560

uccaucgcca ccauccugga gacgcuguac gacuuguag                            4599


