                         SEQUENCE LISTING

<110>  Ultragenyx Pharmaceutical Inc.
       Tachikawa, Kiyoshi
       Perez-Garcia, Carlos Gustavo
       Chivukula, Padmanabh
       Bhaskaran, Hari Prakash
       Cobaugh, Christian W.
       Daugherty, Sean Christopher
 
<120>  THERAPEUTICS FOR PHENYLKETONURIA

<130>  ULPI-040/01WO 315613-2473

<150>  US 62/513,363
<151>  2017-06-07

<160>  46    

<170>  PatentIn version 3.5

<210>  1
<211>  1359
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Consensus Human PAH DNA Coding Sequence

<400>  1
atgtccactg cggtcctgga aaacccaggc ttgggcagga aactctctga ctttggacag       60

gaaacaagct atattgaaga caactgcaat caaaatggtg ccatatcact gatcttctca      120

ctcaaagaag aagttggtgc attggccaaa gtattgcgct tatttgagga gaatgatgta      180

aacctgaccc acattgaatc tagaccttct cgtttaaaga aagatgagta tgaatttttc      240

acccatttgg ataaacgtag cctgcctgct ctgacaaaca tcatcaagat cttgaggcat      300

gacattggtg ccactgtcca tgagctttca cgagataaga agaaagacac agtgccctgg      360

ttcccaagaa ccattcaaga gctggacaga tttgccaatc agattctcag ctatggagcg      420

gaactggatg ctgaccaccc tggttttaaa gatcctgtgt accgtgcaag acggaagcag      480

tttgctgaca ttgcctacaa ctaccgccat gggcagccca tccctcgagt ggaatacatg      540

gaggaagaaa agaaaacatg gggcacagtg ttcaagactc tgaagtcctt gtataaaacc      600

catgcttgct atgagtacaa tcacattttt ccacttcttg aaaagtactg tggcttccat      660

gaagataaca ttccccagct ggaagacgtt tctcagttcc tgcagacttg cactggtttc      720

cgcctccgac ctgtggctgg cctgctttcc tctcgggatt tcttgggtgg cctggccttc      780

cgagtcttcc actgcacaca gtacatcaga catggatcca agcccatgta tacccccgaa      840

cctgacatct gccatgagct gttgggacat gtgcccttgt tttcagatcg cagctttgcc      900

cagttttccc aggaaattgg ccttgcctct ctgggtgcac ctgatgaata cattgaaaag      960

ctcgccacaa tttactggtt tactgtggag tttgggctct gcaaacaagg agactccata     1020

aaggcatatg gtgctgggct cctgtcatcc tttggtgaat tacagtactg cttatcagag     1080

aagccaaagc ttctccccct ggagctggag aagacagcca tccaaaatta cactgtcacg     1140

gagttccagc ccctctatta cgtggcagag agttttaatg atgccaagga gaaagtaagg     1200

aactttgctg ccacaatacc tcggcccttc tcagttcgct acgacccata cacccaaagg     1260

attgaggtct tggacaatac ccagcagctt aagattttgg ctgattccat taacagtgaa     1320

attggaatcc tttgcagtgc cctccagaaa ataaagtaa                            1359


<210>  2
<211>  452
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Consensus Human PAH Amino Acid Sequence

<400>  2

Met Ser Thr Ala Val Leu Glu Asn Pro Gly Leu Gly Arg Lys Leu Ser 
1               5                   10                  15      


Asp Phe Gly Gln Glu Thr Ser Tyr Ile Glu Asp Asn Cys Asn Gln Asn 
            20                  25                  30          


Gly Ala Ile Ser Leu Ile Phe Ser Leu Lys Glu Glu Val Gly Ala Leu 
        35                  40                  45              


Ala Lys Val Leu Arg Leu Phe Glu Glu Asn Asp Val Asn Leu Thr His 
    50                  55                  60                  


Ile Glu Ser Arg Pro Ser Arg Leu Lys Lys Asp Glu Tyr Glu Phe Phe 
65                  70                  75                  80  


Thr His Leu Asp Lys Arg Ser Leu Pro Ala Leu Thr Asn Ile Ile Lys 
                85                  90                  95      


Ile Leu Arg His Asp Ile Gly Ala Thr Val His Glu Leu Ser Arg Asp 
            100                 105                 110         


Lys Lys Lys Asp Thr Val Pro Trp Phe Pro Arg Thr Ile Gln Glu Leu 
        115                 120                 125             


Asp Arg Phe Ala Asn Gln Ile Leu Ser Tyr Gly Ala Glu Leu Asp Ala 
    130                 135                 140                 


Asp His Pro Gly Phe Lys Asp Pro Val Tyr Arg Ala Arg Arg Lys Gln 
145                 150                 155                 160 


Phe Ala Asp Ile Ala Tyr Asn Tyr Arg His Gly Gln Pro Ile Pro Arg 
                165                 170                 175     


Val Glu Tyr Met Glu Glu Glu Lys Lys Thr Trp Gly Thr Val Phe Lys 
            180                 185                 190         


Thr Leu Lys Ser Leu Tyr Lys Thr His Ala Cys Tyr Glu Tyr Asn His 
        195                 200                 205             


Ile Phe Pro Leu Leu Glu Lys Tyr Cys Gly Phe His Glu Asp Asn Ile 
    210                 215                 220                 


Pro Gln Leu Glu Asp Val Ser Gln Phe Leu Gln Thr Cys Thr Gly Phe 
225                 230                 235                 240 


Arg Leu Arg Pro Val Pro Ala His Leu Ser Ser Arg Asp Phe Leu Gly 
                245                 250                 255     


Gly Leu Ala Phe Arg Val Phe His Cys Thr Gln Tyr Ile Arg His Gly 
            260                 265                 270         


Ser Lys Pro Met Tyr Thr Pro Glu Pro Asp Ile Cys His Glu Leu Leu 
        275                 280                 285             


Gly His Val Pro Leu Phe Ser Asp Arg Ser Phe Ala Gln Phe Ser Gln 
    290                 295                 300                 


Glu Ile Gly Leu Ala Ser Leu Gly Ala Pro Asp Glu Tyr Ile Glu Lys 
305                 310                 315                 320 


Leu Ala Thr Ile Tyr Trp Phe Thr Val Glu Phe Gly Leu Cys Lys Gln 
                325                 330                 335     


Gly Asp Ser Ile Lys Ala Tyr Gly Pro Ala His Leu Ser Ser Phe Gly 
            340                 345                 350         


Glu Leu Gln Tyr Cys Leu Ser Glu Lys Pro Lys Leu Leu Pro Leu Glu 
        355                 360                 365             


Leu Glu Lys Thr Ala Ile Gln Asn Tyr Thr Val Thr Glu Phe Gln Pro 
    370                 375                 380                 


Leu Tyr Tyr Val Ala Glu Ser Phe Asn Asp Ala Lys Glu Lys Val Arg 
385                 390                 395                 400 


Asn Phe Ala Ala Thr Ile Pro Arg Pro Phe Ser Val Arg Tyr Asp Pro 
                405                 410                 415     


Tyr Thr Gln Arg Ile Glu Val Leu Asp Asn Thr Gln Gln Leu Lys Ile 
            420                 425                 430         


Leu Ala Asp Ser Ile Asn Ser Glu Ile Gly Ile Leu Cys Ser Ala Leu 
        435                 440                 445             


Gln Lys Ile Lys 
    450         


<210>  3
<211>  129
<212>  RNA
<213>  Tobacco Etch Virus

<400>  3
ucaacacaac auauacaaaa caaacgaauc ucaagcaauc aagcauucua cuucuauugc       60

agcaauuuaa aucauuucuu uuaaagcaaa agcaauuuuc ugaaaauuuu caccauuuac      120

gaacgauag                                                              129


<210>  4
<211>  6
<212>  RNA
<213>  Unknown

<220>
<223>  Kozak Sequence

<400>  4
gccacc                                                                   6


<210>  5
<211>  1359
<212>  RNA
<213>  Homo sapiens

<400>  5
auguccacug cgguccugga aaacccaggc uugggcagga aacucucuga cuuuggacag       60

gaaacaagcu auauugaaga caacugcaau caaaauggug ccauaucacu gaucuucuca      120

cucaaagaag aaguuggugc auuggccaaa guauugcgcu uauuugagga gaaugaugua      180

aaccugaccc acauugaauc uagaccuucu cguuuaaaga aagaugagua ugaauuuuuc      240

acccauuugg auaaacguag ccugccugcu cugacaaaca ucaucaagau cuugaggcau      300

gacauuggug ccacugucca ugagcuuuca cgagauaaga agaaagacac agugcccugg      360

uucccaagaa ccauucaaga gcuggacaga uuugccaauc agauucucag cuauggagcg      420

gaacuggaug cugaccaccc ugguuuuaaa gauccugugu accgugcaag acggaagcag      480

uuugcugaca uugccuacaa cuaccgccau gggcagccca ucccucgagu ggaauacaug      540

gaggaagaaa agaaaacaug gggcacagug uucaagacuc ugaaguccuu guauaaaacc      600

caugcuugcu augaguacaa ucacauuuuu ccacuucuug aaaaguacug uggcuuccau      660

gaagauaaca uuccccagcu ggaagacguu ucucaguucc ugcagacuug cacugguuuc      720

cgccuccgac cuguggcugg ccugcuuucc ucucgggauu ucuugggugg ccuggccuuc      780

cgagucuucc acugcacaca guacaucaga cauggaucca agcccaugua uacccccgaa      840

ccugacaucu gccaugagcu guugggacau gugcccuugu uuucagaucg cagcuuugcc      900

caguuuuccc aggaaauugg ccuugccucu cugggugcac cugaugaaua cauugaaaag      960

cucgccacaa uuuacugguu uacuguggag uuugggcucu gcaaacaagg agacuccaua     1020

aaggcauaug gugcugggcu ccugucaucc uuuggugaau uacaguacug cuuaucagag     1080

aagccaaagc uucucccccu ggagcuggag aagacagcca uccaaaauua cacugucacg     1140

gaguuccagc cccucuauua cguggcagag aguuuuaaug augccaagga gaaaguaagg     1200

aacuuugcug ccacaauacc ucggcccuuc ucaguucgcu acgacccaua cacccaaagg     1260

auugaggucu uggacaauac ccagcagcuu aagauuuugg cugauuccau uaacagugaa     1320

auuggaaucc uuugcagugc ccuccagaaa auaaaguaa                            1359


<210>  6
<211>  158
<212>  RNA
<213>  Xenopus sp.

<400>  6
cuagugacug acuaggaucu gguuaccacu aaaccagccu caagaacacc cgaauggagu       60

cucuaagcua cauaauacca acuuacacuu acaaaauguu gucccccaaa auguagccau      120

ucguaucugc uccuaauaaa aagaaaguuu cuucacau                              158


<210>  7
<211>  100
<212>  RNA
<213>  Unknown

<220>
<223>  Poly(A) 100 Tail

<400>  7
aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa       60

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa                            100


<210>  8
<211>  1359
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Codon-Optimized PAH Coding Sequence

<400>  8
augagcacag cuguauuaga aaaccccggc cugggaagga aacuaucuga uuucggacaa       60

gagacaagcu acauugaaga uaacugcaac cagaacggcg cuauaucacu gaucuuuagc      120

cugaaggaag aagucggcgc uuuggcuaag guucugcggc ucuuugagga gaaugacgug      180

aauuugacgc acaucgaauc aagaccgagc aggcugaaga aggacgaaua cgaauucuuu      240

acccaucucg acaagaggag ucugccugca cugacgaaca uuaucaagau ccugcgccau      300

gacauuggug ccaccguuca ugaacugucc cgggauaaga agaaggacac agugccaugg      360

uuuccacgga ccauucagga acuggacaga uucgcaaauc agauccuguc cuauggagcu      420

gagcuggaug ccgaucaucc cggcuuuaag gacccagugu auagggcucg aaggaagcag      480

uuugcugaca ucgcguauaa cuaucggcac ggccagccua uuccaagagu cgaguauaug      540

gaggaagaga aaaagacaug gggcacagug uucaagacuc ugaaguccuu guauaagacc      600

caugcuugcu acgaguauaa ccacaucuuu cccuugcugg aaaaguacug uggcuuucau      660

gaggacaaca ucccacaacu ggaggacguu agccaguucc uccaaacaug uaccggguuu      720

aggcuacggc ccguagcugg ccugcugagc ucaagagacu uccugggcgg cuuggccuuu      780

cggguguucc auuguacgca guauauccgc cacgguucua agcccaugua uaccccggag      840

cccgauauuu gucaugaacu ccucggccac gugccuuugu uuuccgaccg aaguuuugca      900

caguucaguc aggaaauagg ccucgccucc cugggggcuc cggacgagua uauagagaag      960

cuggcuacua ucuauugguu caccguggaa uuuggucugu guaaacaggg cgacagcauu     1020

aaggcuuaug gcgcuggcuu gcuguccucu uuuggggaac uucaauauug ccugucugag     1080

aagccuaagc ugcugccccu ggaacuggaa aagacggcua uucagaacua uaccgucacu     1140

gaguuucaac cauuguauua cguagccgag agcuuuaaug augccaagga gaaaguccgc     1200

aauuuugccg ccacgauacc gcggccuuuu uccgugcgcu augacccgua cacacagcgu     1260

auugaggugc uggauaacac ucaacaguug aagauucugg cugacucgau uaacuccgaa     1320

auugggaucc uguguagcgc auuacaaaag aucaaauaa                            1359


<210>  9
<211>  1359
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Codon-Optimized PAH Coding Sequence

<400>  9
augucaaccg cuguauuaga gaacccagga uuaggcagaa agcugaguga cuucggccaa       60

gaaaccucuu acaucgagga caacugcaac cagaaugggg cuauuucauu aauuuuuagc      120

cugaaggagg aagucggcgc ucuggcuaaa gugcugaggc uguuugagga aaacgacgug      180

aaucuaacuc acauugaauc uaggccuuca cggcucaaga aggacgaaua ugaauuuuuu      240

acucaucugg acaagcgcuc auugcccgcu cugacgaaua ucaucaagau ccuucggcac      300

gauauugggg cuaccgugca cgaauuguca cgggauaaga agaaggauac ggucccuugg      360

uuuccccgca cuauccaaga acuggaucgc uuugccaacc aaauucuguc cuacggggca      420

gaauuggacg cugaucaucc gggguucaaa gacccagugu auagggcuag gaggaagcag      480

uuugccgaca uugccuauaa cuaucgacac gggcagccca uuccccgugu ggaguacaug      540

gaggaagaga agaaaaccug gggaaccgug uucaagacgu ugaagagucu guauaagaca      600

caugccuguu acgaguauaa ucauaucuuc ccccugcucg agaaguauug uggcuuucau      660

gaggauaaca uaccacagcu ggaggaugug ucacaguuuc ugcaaacaug uacaggcuuc      720

cggcugaggc cuguugcugg ccuacugagc ucuagagacu uucuuggcgg ccuggcguuu      780

agaguguuuc auugcacaca guacauaaga cauggcagca agcccaugua uaccccggaa      840

ccagacauuu gucaugaauu gcugggucau guuccccuau uuucugaccg gaguuucgca      900

caguuuagcc aggagauagg ccuggcuagc uugggcgcuc ccgaugagua uauugagaag      960

cuggcaacaa ucuauugguu caccguugaa uuuggccugu guaaacaggg ggacucgauc     1020

aaggccuaug gcgcugggcu gcuaucgagu uucggcgaac ugcaguauug uuuguccgaa     1080

aagccuaagc ugcugccauu ggagcuggaa aagacagcua uccaaaacua cacggucacc     1140

gaguuucagc cacuguauua cguagccgaa uccuuuaacg augcaaagga aaagguccgc     1200

aauuucgcug ccacuauucc gcggccuuuu aguguacgau augacccgua uacccaaagg     1260

auugaggugc uggacaauac ucagcagcug aaaauacugg cugacuccau caacucugag     1320

auuggcaucc ugugcuccgc cuugcaaaag aucaaauaa                            1359


<210>  10
<211>  1359
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Codon-Optimized PAH Coding Sequence

<400>  10
augaguacag cgguauugga aaauccagga cuugggagaa aauugagcga cuuuggccaa       60

gaaacgucgu auaucgaaga uaauuguaac cagaauggag caauuucacu gaucuuuagu      120

cugaaagagg aaguuggcgc acuggcuaag guucugaggu uguuugagga gaacgacgua      180

aaccugaccc auauugagag caggccgucu agauugaaga aggacgaaua cgaguuuuuc      240

acccaucugg auaagcguuc cuugcccgcc cugaccaaca uaaucaagau uuugcggcau      300

gacaucggcg cuacggugca cgaacuauca cgcgacaaga agaaagacac cgugccaugg      360

uuuccaagga ccauacagga gcuggaccgg uuugcgaacc agauccugag cuacggcgcc      420

gagcuggacg ccgaccaucc gggguucaag gauccagugu aucgcgcuag gaggaagcag      480

uuugccgaua uugcuuauaa cuaucgacau ggucaaccca uuccacgggu ggaguauaug      540

gaggaagaga agaaaaccug gggcaccguc uuuaagacgc ugaagucccu guacaagacc      600

cacgcuugcu acgaguauaa ccacauuuuu ccacugcugg aaaaguauug uggcuuucau      660

gaggacaaua uuccgcaacu ggaggacgug ucucaguucu ugcaaacgug uaccggguuu      720

agacugcgcc caguggccgg ccuguugucc ucccgggacu uucugggcgg ccuggccuuc      780

cggguguucc auugcacgca guacauaaga cauggcagca agccaaugua uacaccagag      840

ccugacauuu gucacgaacu gcugggccau gugccguuau uuuccgaucg aagcuucgcc      900

caguuuaguc aggaaauugg ccuggcgucc uugggugccc ccgaugagua uauugaaaag      960

cucgcaacua ucuauugguu uacugucgaa uucggccugu guaaacaggg cgauucuauc     1020

aaggcuuaug gcgcuggccu gcugagcuca uuuggggaac uccaauauug uuugucugag     1080

aagccuaagu ugcugccucu ggaacuggaa aagacggcaa uccagaacua uacagugacg     1140

gaauuucagc cucuguacua uguagcagaa agcuuuaaug augcuaagga aaagguucgc     1200

aacuucgcug ccacaauacc acggccauuu uccguccgcu augacccaua uacacagcgg     1260

auugaggugc uggacaacac acagcaacug aaaauccugg ccgauaguau uaacagcgag     1320

auuggcaucc uguguagcgc ccugcaaaag aucaaguaa                            1359


<210>  11
<211>  1359
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Codon-Optimized PAH Coding Sequence

<400>  11
augucaaccg cugugcuuga aaaccccgga cucggccgca aguuaucuga uuucggacaa       60

gaaaccucau acauugagga caacugcaac cagaacgggg cgaucucacu gaucuucucg      120

cugaaagaag aagucggagc auuggcgaag guccugaggc uguucgagga aaacgacgug      180

aaccugaccc acauagaauc gcggccguca cggcuaaaga aggaugaaua cgaguucuuc      240

acgcaccugg acaagcgguc gcugccggcg cugacuaaca ucaucaagau ucugcggcac      300

gauaucgggg caaccgugca ugagcugagc cgggacaaga agaaggacac cgugccgugg      360

uuuccccgga caauccagga gcuggaccgc uucgccaauc aaauccugag cuacggugca      420

gaacuggacg cggaccaccc aggguucaag gacccggugu acagagccag gagaaagcag      480

uucgccgaua uugcauacaa cuaccgccac ggccagccga uuccccgcgu ggaguacaug      540

gaagaagaga agaaaaccug ggggacugug uucaagacuc ugaagucccu guauaagacc      600

cacgcguguu augaguacaa ccauauuuuc ccgcugcugg aaaaguauug cggauuccau      660

gaggauaaca uuccgcagcu ggaggacgug ucacaguuuc ugcaaacuug caccggauuc      720

cggcugaggc cggucgccgg auugcucucc ucccgggauu uccucggcgg acuggcauuc      780

agaguguucc acugcaccca guacauuaga cacgggucga agccgaugua caccccugag      840

ccugacaucu gccaugaacu gcuuggccac gucccguugu uuucggaccg cucauucgca      900

caauucagcc aggagauugg acucgcauca cuuggagccc ccgaugagua caucgagaag      960

cucgccacca ucuacugguu caccguggag uucggccugu gcaaacaggg ggauuccauc     1020

aaagcuuacg gcgcgggccu ccuguccuca uucggggaau ugcaguacug ucucuccgaa     1080

aagccgaagc ugcugccccu ugaacucgaa aagaccgcaa uccagaacua caccgugacu     1140

gaauuucagc cgcucuacua cguggccgag agcuucaacg acgcuaagga aaagguccgc     1200

aacuucgccg ccacuauccc gcgaccguuc uccgugcgcu acgacccaua cacucagcgc     1260

aucgaggugc uggacaauac ccagcagcuc aagauccugg cugacuccau caacucggag     1320

auugggaucc ugugcucggc ccugcaaaag aucaaguaa                            1359


<210>  12
<211>  1359
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Codon-Optimized PAH Coding Sequence

<400>  12
augagcaccg ccguccuuga aaacccuggc cuuggaagaa agcugaguga cuucggacag       60

gaaacuucgu auaucgagga caacugcaac cagaacgggg ccauuagccu gaucuuuuca      120

cugaaagagg aggucggagc ucuggccaag guccuucggc uguucgagga aaaugacgug      180

aaccugacac acaucgaauc ccggccgucg cggcugaaga aggaugaaua cgaguucuuc      240

acgcaucugg acaagcgguc ccugccggcc uugaccaaca ucauaaagau ucugcggcac      300

gauauuggcg cgacugugca cgagcugucc cgcgacaaaa agaaggacac cgugcccugg      360

uuuccgagga cuauucagga gcuggaccgg uucgcuaacc aaauccuauc cuacggagcc      420

gagcuggacg cggaucaccc gggauucaag gacccagugu accgagcacg gagaaagcag      480

uucgcagaca uugccuacaa cuaccgccac gggcagccaa ucccccgcgu ggaguauaug      540

gaagaagaga agaaaaccug ggggaccgug uuuaagaccc ucaagucacu guacaagacc      600

caugccugcu acgaguacaa ccacaucuuc ccgcugcugg aaaaguacug cggauuccac      660

gaggauaaca ucccccaauu ggaagaugug ucacaguucu uacaaacgug uacuggguuc      720

agacuccggc cgguggcggg ccugcugagc ucccgcgacu uccugggcgg ccuggccuuc      780

cggguguucc acugcaccca guacaucaga cacgguagca agccgaugua caccccggaa      840

cccgacaucu gccaugaacu ccugggacac gugcccuugu ucuccgaccg cuccuucgcg      900

caauucuccc aagaaaucgg acuggcuucc cugggugccc cugaugagua cauugaaaag      960

cucgccacca ucuauugguu cacgguggag uucgggcugu gcaaacaggg ggacucgauc     1020

aaggccuacg gggccggccu ucuguccucu uuuggggaac ugcaguacug ccuguccgag     1080

aagccgaagc ugcucccgcu ggagcuggaa aagaccgcaa uucagaacua caccgugacc     1140

gaauuccagc cgcucuacua cguggcggaa agcuucaaug augccaagga gaagguccgc     1200

aacuucgccg ccaccauucc gaggccguuc uccguccgcu acgaccccua cacccaaagg     1260

aucgaggugc ucgacaacac ccagcagcug aagauccugg ccgacucgau uaacuccgaa     1320

aucggaaucc uguguagcgc guugcagaag aucaaguaa                            1359


<210>  13
<211>  1359
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Codon-Optimized PAH Coding Sequence

<400>  13
augucuacug cugugcuuga aaaccccgga cucggccgaa agcuuuccga cuucggacag       60

gaaaccucgu acaucgagga uaauugcaac cagaauggug ccaucucccu caucuuuucg      120

cugaaagaag aggucggcgc ccuggcuaag guccugaggc uguucgaaga gaacgacguc      180

aaccugaccc acaucgaauc aagaccgucc agacucaaga aggaugaaua ugaauucuuu      240

acccaccugg acaagaggag ccugccggcc cuuaccaaca ucauuaagau ucugcgccac      300

gacaucggcg cuaccgugca ugaacugucc cgcgacaaga agaaggauac cgugccaugg      360

uucccccgga cgauucagga gcucgaccgg uucgcaaacc agauccuguc auacggagcc      420

gaacuggacg cggaccaccc gggauucaag gacccugugu accgcgcacg gcggaagcag      480

uucgcggaca ucgccuacaa cuaccgccac gggcaaccca uuccgcgcgu cgaguacaug      540

gaagaggaga agaaaaccug ggggacugug uucaagaccc ucaagucccu guauaagacc      600

cacgccugcu acgaguacaa ccacaucuuc ccccugcugg agaaguacug uggcuuccau      660

gaggacaaca ucccgcaguu ggaggacgug ucgcaguuuc uccaaaccug uacuggauuc      720

agacugaggc ccguggccgg ucugcucuca ucgcgggacu uucugggagg ccuggcauuc      780

cgcguguucc acugcacgca guacauuaga cauggaucca agccaaugua cacucccgaa      840

ccugacaucu gccaugaacu gcugggccac gugccacucu uuucggaucg gagcuucgcg      900

caauucuccc aagaaaucgg guuggcaucg cugggugccc cggaugagua cauugagaag      960

cuggccacca ucuacugguu caccguggag uucggacugu gcaaacaggg ggauagcauc     1020

aaggcauaug gcgcaggccu gcugagcucg uucggagagc uccaguacug ccucucggaa     1080

aagccuaagu ugcuuccgcu ggaacuggag aaaacagcaa uccagaacua caccgugacc     1140

gaguuccagc cccucuacua cguggcggag agcuucaacg acgcuaagga gaagguccgc     1200

aacuucgcgg cgacgauucc ucggccuuuc uccgugcgcu acgacccgua cacccagcgg     1260

auugaagugu uagauaauac ccagcagcug aagauucugg cggacuccau caacuccgaa     1320

aucggaaucc ugugcuccgc auugcaaaag auuaaguaa                            1359


<210>  14
<211>  1359
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Codon-Optimized PAH Coding Sequence

<400>  14
augagcacag cuguauuaga aaaucccggg cuaggccgca aauugaguga cuuugggcag       60

gagacuagcu acauugagga caacuguaac cagaacggcg cuauaagccu uaucuuuucg      120

cugaaagagg aaguuggcgc ucuggcuaag guccugaggu uguuugagga gaacgacgug      180

aaccugacac acauugagag cagaccaagc cgacugaaga aggacgaaua cgaauucuuu      240

acgcaccugg acaagagguc uuuaccggcu cuuacgaaca ucaucaagau ccugagacau      300

gauauugggg cuacagugca ugagcuuucc cgcgacaaga agaaggacac agugcccugg      360

uucccacgga ccauucagga acucgaucgc uuugcuaauc aaauacucuc auacggcgcu      420

gagcuggacg cugaucaucc gggcuuuaag gacccagugu auagggcccg uaggaagcag      480

uucgcugaca ucgccuacaa uuaucggcac ggccaaccca uuccccgagu cgaguacaug      540

gaggaagaga aaaagaccug gggcaccguu uucaaaaccc ugaaguccuu guauaagacc      600

cacgcuuguu augaguauaa ucauaucuuu ccuuugcucg aaaaguauug uggcuuucau      660

gaggacaaca uuccccaacu ggaagaugua ucccaguucc uacaaacaug cacuggcuuu      720

agauugcggc caguggcagg ccuucugagu ucaagggacu uucuuggcgg ccuggcuuuu      780

cgggucuuuc auuguaccca guacauucgg cauggaucca agccgaugua uacccccgag      840

ccugacauuu gccaugaacu gcugggucau guaccccucu uuuccgaucg gagcuucgcu      900

caguuuagcc aggaaauugg uuuggcuuca cugggugcac cagaugagua uauagagaag      960

uuggcuacga ucuauugguu uaccguggag uuuggccugu gcaaacaggg cgacaguauc     1020

aaggccuaug gcgccggccu gcuaaguagc uucggagaac uucaguauug ucucucugaa     1080

aaaccuaagc uccuuccgcu ggagcuggaa aagaccgcua uucaaaacua uacugugaca     1140

gaauuucagc cucuguauua cguugcugaa uccuuuaaug acgcuaagga aaaaguccgg     1200

aacuuugcug caacgauccc uagaccauuc ucugugcgcu augacccaua uacucaaagg     1260

auugaagugc uggauaauac ucagcagcuc aagauuuugg cugauucuau caacuccgaa     1320

aucgggauac uguguuccgc ccugcaaaag aucaaguaa                            1359


<210>  15
<211>  1359
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Codon-Optimized PAH Coding Sequence

<400>  15
augagcaccg ccguccuuga gaacccuggc uugggaagaa aguuguccga uuuuggccaa       60

gaaaccuccu auaucgagga uaacugcaac cagaacggag ccaucucccu caucuucucg      120

cugaaagagg aagucggcgc ucuggccaag guccuccgcc uguucgagga aaacgacgug      180

aaccugaccc acauugaaag caggcccucg agacucaaga aggacgaaua cgaauucuuc      240

acucaccugg acaagcgcuc acuuccggcc cugaccaaca uuaucaagau ccuucggcac      300

gacauuggug ccaccgugca cgaacugagc cgcgacaaga agaaggacac ugugccaugg      360

uuuccgcgga ccauccagga gcucgauaga uucgccaauc aaauucucuc guacggagcg      420

gaacuggacg ccgaccaucc uggguuuaag gacccggucu accgggccag gaggaagcag      480

uucgccgaua ucgccuacaa cuaucgccac ggucaaccaa ucccccgagu ggaguacaug      540

gaggaggaga aaaagaccug ggguaccgug uucaagacuc ugaagucacu guacaaaacu      600

caugccugcu acgaguacaa ccacaucuuu ccucuucucg aaaaguacug cggauuccac      660

gaggacaaca ucccucaacu cgaggacgug ucgcaguucc ugcaaacuug uacuggauuc      720

cgccugcggc cuguggccgg acugcucucc ucccgggauu uccucggugg ccuggccuuu      780

cggguguucc auugcaccca guacaucaga cacggcucca agcccaugua cacaccugaa      840

ccugacaucu gccaugagcu gcucggucac gugccucugu ucucggaccg guccuucgcc      900

caauucagcc aggaaauugg ccucgccuca cugggugccc cugaugagua caucgaaaag      960

cuggccacca ucuacugguu caccguggag uucggacugu gcaaacaggg agacuccauu     1020

aaggcguacg gugccggccu guuguccucc uucggggaac ugcaguauug cuugagcgaa     1080

aagccuaaac ugcugccccu ggagcucgaa aagaccgcga uccagaacua caccgugacu     1140

gaguuccagc cucuguacua cguggccgaa uccuucaacg acgcuaagga aaagguccgc     1200

aauuucgccg caaccauccc aagacccuuc uccgugcgcu acgaccccua cacgcagcgg     1260

auugaagugc uggacaacac ccagcagcug aagauucugg ccgauucuau caacuccgag     1320

aucggaaucc uguguagcgc gcugcagaag auuaaguaa                            1359


<210>  16
<211>  1359
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Codon-Optimized PAH Coding Sequence

<400>  16
auguccaccg ccguccucga aaaccccggu cuggguagaa agcucuccga cuucggucaa       60

gaaacuuccu acaucgagga uaacugcaac cagaacggug ccaucagccu gauuuucuca      120

cugaaagaag aggucggagc ccuggccaag guccucagac uguucgaaga gaacgauguc      180

aaccugaccc auaucgaaag ccgccccagc cggcugaaga aggacgaaua cgaauucuuc      240

acacaccucg acaagagguc ccuuccggcc uugacuaaca uuaucaagau ccuccggcac      300

gacauuggcg ccacugugca ugaacugagc cgcgauaaga agaaggacac cgugcccugg      360

uucccaagaa cuauccagga gcuggaccgc uucgccaauc aaauccucuc cuauggggcc      420

gaacuugacg ccgaccaucc uggguuuaag gaccccgugu accgggccag gcggaagcag      480

uucgccgaua ucgccuacaa cuauagacac ggacagccga ucccccgcgu ggaguacaug      540

gaagaggaga aaaagacuug gggcaccgug uucaagaccc ucaagucccu guacaagacc      600

caugccugcu acgaguacaa ccacauuuuc ccgcugcucg agaaguacug cggauuccac      660

gaagauaaua uuccgcagcu cgaggacgug ucccaguucc uccaaacuug cacugguuuu      720

cggcugaggc cgguggcggg auugcucucc ucccgggauu uucugggagg ccucgccuuc      780

cgaguguucc acugcacuca guauauucgg cacggaucca agccaaugua cacuccugaa      840

cccgacaucu gucacgaacu gcugggccac gugccccucu ucuccgaccg gagcuucgcc      900

caguucagcc aggaaaucgg ccucgcaagc cugggugccc cugacgagua caucgaaaag      960

cucgcgacca ucuacugguu caccguggag uucggucugu gcaaacaggg agauuccauc     1020

aaggccuacg gcgccggccu gcuuuccucg uucggagagc ugcaauacug ccugucggag     1080

aagccaaagc uccugccguu ggagcucgaa aagacugcca uccaaaacua caccgugacu     1140

gaauuucagc cucuguacua cguggccgag uccuucaacg acgccaagga gaaaguccgc     1200

aacuucgcug cuaccauccc ucgcccguuu uccgugcgcu acgacccuua cacccaacgg     1260

auugaggugc ucgacaacac ucagcagcuu aagauacugg ccgacuccau caacucggag     1320

aucggaauuc uguguagcgc gcugcagaag auuaaguaa                            1359


<210>  17
<211>  1359
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Codon-Optimized PAH Coding Sequence

<400>  17
auguccacug ccguucucga aaacccaggc cucggaagaa aguuaagcga uuuuggccag       60

gaaaccuccu auaucgagga uaacuguaac cagaauggcg cuauuagucu gaucuuuagu      120

cugaaagaag aaguuggugc acuggcaaag guccucagac uguuugagga aaaugacgug      180

aaccugaccc auauugaaag caggccuagc aggcucaaga aggacgaaua ugaguucuuu      240

acucauuugg acaagcgauc gcugccugcu uugacgaaca ucaucaagau ucuccggcac      300

gacaucggcg caaccgugca ugaacugagc agagacaaga agaaggacac ggugccaugg      360

uuuccaagga caauucagga gcuggaccgc uucgcuaauc aaauccuguc auauggggcu      420

gaacucgacg cugaccaccc uggcuuuaag gauccugucu aucgagcucg gcgcaaacag      480

uuugccgaua uagcuuauaa cuaucggcau ggccaaccca ucccccgggu ggaguauaug      540

gaggaggaga agaaaacuug gggcacagug uuuaagacac ugaaguccuu guauaagaca      600

caugcaugcu acgaguacaa ucauauuuuc ccgcugcuug agaaguauug uggcuuucau      660

gaggauaaca uuccccaacu ggaggacgug ucccaguuuc ugcaaacaug cacaggcuuu      720

aggcugcggc cuguugcugg ccuacugucc ucccgggacu uuuugggcgg acuggccuuc      780

cgcguguucc auuguaccca guacauuaga cacggcucua agccaaugua uaccccugag      840

ccugacauuu gccaugaacu gcucggccac gugccacugu uuagcgaucg gagcuucgcg      900

caauucagcc aggaaauugg gcuggccucu uugggggccc ccgacgagua caucgagaag      960

uuggcuacca ucuacugguu cacgguagag uuugggcugu guaaacaggg cgacagcauu     1020

aaggccuaug gcgcuggccu ccuguccucc uuuggugaac ugcaguacug ucuuagcgaa     1080

aaaccgaagc ugcugcccuu ggagcucgaa aagaccgcua uacagaauua caccguaacu     1140

gaauuucagc cccuguauua uguagcagag agcuuuaacg acgccaagga aaaaguccgc     1200

aacuuugcug ccacaauucc aaggccuuuu uccgugcguu augaccccua uacgcaaagg     1260

auagaagugu uggacaauac ccaacagcug aagauucugg cugauuccau aaacagcgaa     1320

aucgguaucc uguguuccgc ucugcaaaag aucaaguaa                            1359


<210>  18
<211>  1359
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Codon-Optimized PAH Coding Sequence

<400>  18
augucaacug ccgugcucga aaaccccgga cuuggaagaa agcugucgga cuucggucaa       60

gaaaccucau acaucgagga uaacugcaac cagaaugggg cgauuucccu caucuucuca      120

cugaaagaag aagucggugc acuggcgaag guccugcggc uguucgaaga gaacgaugug      180

aaccucacuc auaucgagag caggccuucc cggcuaaaga aggacgaaua cgaguucuuu      240

acccaccuug acaagagaag ccucccggcc cugaccaaca uaaucaagau ucugagacac      300

gacaucgggg ccaccgugca cgagcugucc agggacaaga agaaggacac ugugccaugg      360

uucccgcgca cgauccaaga guuggaucgc uucgcuaacc aaauccuguc cuacggcgcc      420

gaacuggacg ccgaccaccc cggauucaag gaccccgugu aucgggcccg gagaaagcag      480

uuugcugaua uugcauacaa cuaccgccau ggacagccca ucccccgcgu ggaguacaug      540

gaggaggaaa agaaaacaug gggcacugug uucaagaccc ucaagucccu guacaagacc      600

caugcuugcu acgaguacaa ccacauuuuc ccucugcugg agaaguacug cggcuuccac      660

gaggacaaca ucccccaacu ggaggacgug ucccaguucc ugcaaaccug uacuggguuc      720

cgccugcggc ccguggcggg ccugcugucc ucucgggacu uucuuggugg acucgccuuc      780

cgcguguucc acugcaccca guacauucgg caugguucca aacccaugua cacucccgaa      840

cccgacauuu gccacgaacu guugggccac gugccccugu ucuccgaccg gagcuucgcc      900

caguucagcc aggagauugg acuggccucg cugggggcgc cugaugagua cauugagaag      960

uuggccacua ucuacugguu cacuguggaa uucggacugu gcaaacaggg cgauuccauc     1020

aaggcuuacg gagcaggacu gcugucgagc uuuggcgaac ugcaguacug ccucuccgaa     1080

aagccuaagc uccucccgcu cgaacuugaa aagaccgcga uccagaacua uacugugacc     1140

gaauuucagc cgcuguacua cguggccgag uccuucaacg augccaagga aaagguccgc     1200

aacuucgccg ccaccauccc ucggccguuc uccguccgau augacccgua cacucagagg     1260

aucgaagugc uggauaauac ucagcagcuc aagauccugg cggacaguau caauagcgag     1320

auuggaaucc uguguucugc ccugcaaaag aucaaguaa                            1359


<210>  19
<211>  1359
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Codon-Optimized PAH Coding Sequence

<400>  19
augagcaccg ccguacuuga aaacccugga cugggccgca aacuguccga cuucggccaa       60

gagacuuccu auaucgagga caacugcaac cagaauggug ccauuucacu gaucuuuagu      120

cugaaggagg aagucggugc ccuggcuaag guucugcggu uguuugaaga aaacgacgug      180

aaucugacgc auauagaaag caggcccagc aggcugaaga aggaugagua cgaauucuuu      240

acucaccucg acaagcgguc uuugcccgcc uuaacuaaca uuaucaagau cuugcgccau      300

gauauuggug cuaccguaca ugaacuguca cgggauaaga agaaggacac gguuccaugg      360

uuuccucgua caauucagga auuggacaga uucgcaaacc agaucuuaag uuauggcgcu      420

gaacuggacg ccgaucaucc cggcuuuaag gaccccgugu aucgagcuag gagaaagcag      480

uuugccgaca ucgcuuauaa uuaucggcau ggccagccua uuccgagggu ggaguauaug      540

gaggaagaga agaaaaccug ggguacugug uuuaagacuc ugaagucucu guauaagacc      600

cacgcuuguu acgaguacaa ucacauauuc ccgcuguugg agaaguauug uggcuuucau      660

gaggacaaca ucccacaacu ggaggacgug ucccaguucc uucaaaccug uaccggcuuu      720

agacugaggc ccguagcagg gcugcugagc agcagagauu uucugggagg cuuggcauuu      780

cgaguguuuc auuguacaca guauauucgc cauggcucga aacccaugua cacacccgag      840

ccagauaucu gucaugagcu ccugggccac gucccccugu uuuccgaccg gagcuucgcu      900

caguuuagcc aagaaauagg ccucgcuagc uugggugcac cagacgagua uauugaaaag      960

cuggcgacca uauauugguu uacuguggaa uucggccugu guaaacaggg cgauuccauu     1020

aaggcauaug gcgcuggccu ccuauccucu uuuggcgaac ugcaauauug cuuguccgag     1080

aagccuaagc uguugccacu cgaacuggaa aagacugcua uucaaaacua uaccguuacu     1140

gaauuccagc cucuguacua cguggcugaa uccuuuaaug acgcuaaaga gaaaguucgg     1200

aacuuugcug ccacaauccc acggccguuu ucugugcgcu augacccgua cacacagagg     1260

aucgaagucc uggacaacac ccagcagcua aagauccugg cugauaguau uaauagcgag     1320

auugggaucc uguguagugc ucugcaaaag auuaaguaa                            1359


<210>  20
<211>  1359
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Codon-Optimized PAH Coding Sequence

<400>  20
augagcaccg ccguccuuga aaacccuggc cuuggaagaa agcugaguga cuucggacag       60

gaaacuucgu auaucgagga caacugcaac cagaacgggg ccauuagccu gaucuuuuca      120

cugaaagagg aggucggagc ucuggccaag guccuucggc uguucgagga aaaugacgug      180

aaccugacac acaucgaauc ccggccgucg cggcugaaga aggaugaaua cgaguucuuc      240

acgcaucugg acaagcgguc ccugccggcc uugaccaaca ucauaaagau ucugcggcac      300

gauauuggcg cgacugugca cgagcugucc cgcgacaaaa agaaggacac cgugcccugg      360

uuuccgagga cuauucagga gcuggaccgg uucgcuaacc aaauccuauc cuacggagcc      420

gagcuggacg cggaucaccc gggauucaag gacccagugu accgagcacg gagaaagcag      480

uucgcagaca uugccuacaa cuaccgccac gggcagccaa ucccccgcgu ggaguauaug      540

gaagaagaga agaaaaccug ggggaccgug uuuaagaccc ucaagucacu guacaagacc      600

caugccugcu acgaguacaa ccacaucuuc ccgcugcugg aaaaguacug cggauuccac      660

gaggauaaca ucccccaauu ggaagaugug ucacaguucu uacaaacgug uacuggguuc      720

agacuccggc cgguggcggg ccugcugagc ucccgcgacu uccugggcgg ccuggccuuc      780

cggguguucc acugcaccca guacaucaga cacgguagca agccgaugua caccccggaa      840

cccgacaucu gccaugaacu ccugggacac gugcccuugu ucuccgaccg cuccuucgcg      900

caauucuccc aagaaaucgg acuggcuucc cugggugcac cugaugaaua cauugaaaag      960

cucgccacaa uuuacugguu uacuguggag uuugggcucu gcaaacaagg agacuccaua     1020

aaggcauaug gugcugggcu ccugucaucc uuuggugaau uacaguacug cuuaucagag     1080

aagccaaagc uucucccccu ggagcuggag aagacagcca uccaaaauua cacugucacg     1140

gaguuccagc cccucuauua cguggcagag aguuuuaaug augccaagga gaaaguaagg     1200

aacuuugcug ccacaauacc ucggcccuuc ucaguucgcu acgacccaua cacccaaagg     1260

auugaggucu uggacaauac ccagcagcuu aagauuuugg cugauuccau uaacagugaa     1320

auuggaaucc uuugcagugc ccuccagaaa auaaaguaa                            1359


<210>  21
<211>  1359
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Codon-Optimized PAH Coding Sequence

<400>  21
augagcaccg ccguccuuga gaacccuggc uugggaagaa aguuguccga uuuuggccaa       60

gaaaccuccu auaucgagga uaacugcaac cagaacggag ccaucucccu caucuucucg      120

cugaaagagg aagucggcgc ucuggccaag guccuccgcc uguucgagga aaacgacgug      180

aaccugaccc acauugaaag caggcccucg agacucaaga aggacgaaua cgaauucuuc      240

acucaccugg acaagcgcuc acuuccggcc cugaccaaca uuaucaagau ccuucggcac      300

gauaucgggg caaccgugca ugagcugagc cgggacaaga agaaggacac cgugccgugg      360

uuuccccgga caauccagga gcuggaccgc uucgccaauc aaauccugag cuacggugca      420

gaacuggacg cggaccaccc aggguucaag gacccggugu acagagccag gagaaagcag      480

uucgccgaua uugcauacaa cuaccgccac ggccagccga uuccccgcgu ggaguacaug      540

gaagaagaga agaaaaccug ggggacugug uucaagacuc ugaagucccu guauaagacc      600

cacgcguguu augaguacaa ccauauuuuc ccgcugcugg aaaaguauug cggauuccau      660

gaggauaaca uuccgcagcu ggaggacgug ucacaguuuc ugcaaacuug caccggauuc      720

cggcugaggc cggucgccgg auugcucucc ucccgggauu uccucggcgg acuggcauuc      780

cggguguucc acugcaccca guacaucaga cacgguagca agccgaugua caccccggaa      840

cccgacaucu gccaugaacu ccugggacac gugcccuugu ucuccgaccg cuccuucgcg      900

caauucuccc aagaaaucgg acuggcuucc cugggugcac cugaugaaua cauugaaaag      960

cucgccacaa uuuacugguu uacuguggag uuugggcucu gcaaacaagg agacuccaua     1020

aaggcauaug gugcugggcu ccugucaucc uuuggugaau uacaguacug cuuaucagag     1080

aagccaaagc uucucccccu ggagcuggag aagacagcca uccaaaauua cacugucacg     1140

gaguuccagc cccucuauua cguggcagag aguuuuaaug augccaagga gaaaguaagg     1200

aacuuugcug ccacaauacc ucggcccuuc ucaguucgcu acgacccaua cacccaaagg     1260

auugaggucu uggacaauac ccagcagcuu aagauuuugg cugauuccau uaacagugaa     1320

auuggaaucc uuugcagugc ccuccagaaa auaaaguaa                            1359


<210>  22
<211>  1359
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Codon-Optimized PAH Coding Sequence

<400>  22
augagcaccg ccguccuuga aaacccuggc cuuggaagaa agcugaguga cuucggacag       60

gaaacuucgu auaucgagga caacugcaac cagaacgggg ccauuagccu gaucuuuuca      120

cugaaagagg aggucggagc ucuggccaag guccuucggc uguucgagga aaaugacgug      180

aaccugacac acaucgaauc ccggccgucg cggcugaaga aggaugaaua cgaguucuuc      240

acgcaucugg acaagcgguc ccugccggcc uugaccaaca ucauaaagau ucugcggcac      300

gauaucgggg caaccgugca ugagcugagc cgggacaaga agaaggacac cgugccgugg      360

uuuccccgga caauccagga gcuggaccgc uucgccaauc aaauccugag cuacggugca      420

gaacuggacg cggaccaccc aggguucaag gacccggugu acagagccag gagaaagcag      480

uucgccgaua uugcauacaa cuaccgccac ggccagccga uuccccgcgu ggaguacaug      540

gaagaagaga agaaaaccug ggggacugug uucaagacuc ugaagucccu guauaagacc      600

cacgcguguu augaguacaa ccauauuuuc ccgcugcugg aaaaguauug cggauuccau      660

gaggauaaca uuccgcagcu ggaggacgug ucacaguuuc ugcaaacuug caccggauuc      720

cggcugaggc cggucgccgg auugcucucc ucccgggauu uccucggcgg acuggcauuc      780

cggguguucc acugcaccca guacaucaga cacgguagca agccgaugua caccccggaa      840

cccgacaucu gccaugaacu ccugggacac gugcccuugu ucuccgaccg cuccuucgcg      900

caauucuccc aagaaaucgg acuggcuucc cugggugcac cugaugaaua cauugaaaag      960

cucgccacaa uuuacugguu uacuguggag uuugggcucu gcaaacaagg agacuccaua     1020

aaggcauaug gugcugggcu ccugucaucc uuuggugaau uacaguacug cuuaucagag     1080

aagccaaagc uucucccccu ggagcuggag aagacagcca uccaaaauua cacugucacg     1140

gaguuccagc cccucuauua cguggcagag aguuuuaaug augccaagga gaaaguaagg     1200

aacuuugcug ccacaauacc ucggcccuuc ucaguucgcu acgacccaua cacccaaagg     1260

auugaggucu uggacaauac ccagcagcuu aagauuuugg cugauuccau uaacagugaa     1320

auuggaaucc uuugcagugc ccuccagaaa auaaaguaa                            1359


<210>  23
<211>  1359
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Codon-Optimized PAH Coding Sequence

<400>  23
augucaacug cuguguuaga aaacccugga cucggacgca aacucucgga cuucggacag       60

gaaaccuccu auaucgagga uaacugcaac cagaauggag ccaucucacu gaucuucucg      120

cugaaagaag aggucggagc ccuggcuaag guccugagac uguuugagga gaacgaugug      180

aaccuuacuc acaucgaauc gcggcccagc agacugaaga aggaugagua cgaguucuuc      240

acccaccugg auaagcgcuc acugccggca cucacaaaca uuaucaagau ucugagacac      300

gacaucggcg caaccgucca ugagcugagc cgcgacaaga agaaggacac ugucccaugg      360

uuuccccgga ccauccaaga gcuggaccgc uucgcaaacc agauccuguc cuacggcgcg      420

gaacuggacg ccgaucaccc gggguucaag gacccggugu acagagcacg ccgcaagcag      480

uucgccgaua uugccuacaa cuaucggcau gggcagccga ucccuagggu ggaguacaug      540

gaagaggaaa agaaaaccug gggcaccgug uuuaagacuc ucaagucacu guacaagacc      600

cacgccugcu acgaguacaa ccacaucuuc ccgcuccuug aaaaguacug cggguuucac      660

gaggauaaca ucccgcaacu ggaggacgug ucacaguucc uucaaaccug uaccggauuc      720

cggcugcgcc cgguggccgg acucuuguca ucccgggacu uccuuggggg gcuggcguuc      780

cgaguguucc auuguaccca guacauucgg cauggcucaa agcccaugua caccccggaa      840

ccagacaucu gccacgaguu gcucggccac gugccguugu ucuccgaccg gagcuucgcg      900

caguucagcc aggaaauugg ccuggcaucg cugggugcac cggacgagua caucgaaaag      960

cucgcuacga ucuauugguu cacuguggag uucgggcugu gcaaacaggg agacucuauc     1020

aaggcuuacg gggcgggacu gcugucguca uucggcgaau ugcaguacug ccuguccgag     1080

aagccgaagc uccugccgcu ggaacuggaa aagaccgcga uucaaaacua cacugugacc     1140

gaauuccagc cccucuacua cguggccgaa agcuucaaug acgcgaagga aaaaguccgg     1200

aacuucgccg ccaccauccc gaggcccuuc uccgugcgcu acgacccgua cacccagcgc     1260

auugaggugc uagacaacac ccagcagcug aagauucugg cagacuccau aaacucggag     1320

aucgggauuc ugugcucggc acugcaaaag aucaaguaa                            1359


<210>  24
<211>  1359
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Codon-Optimized PAH Coding Sequence

<400>  24
augucaacug cagugcucga aaaccccggu cuaggacgaa agcucuccga cuucggacaa       60

gaaaccucgu acaucgagga caauugcaac cagaacggag ccauuucauu gauuuucucg      120

cugaaagaag aagucggggc ucucgcgaaa gugcugaggc uguucgaaga gaacgacgug      180

aacuugaccc acauugaaag cagacccagc cgccugaaga aggacgaaua cgaguucuuc      240

acccaucugg auaagcgguc acuuccggcc cucaccaaca ucaucaagau cuuacgccau      300

gauauugggg caaccgugca cgagcugucg agggauaaga agaaggacac cgucccgugg      360

uuuccgcgga ccauacagga acuggaccgg uucgcaaacc aaauucuguc auacggggcg      420

gaacuggacg cggaccaucc cggguucaag gacccggugu accgggccag gagaaagcag      480

uucgccgaua ucgcguacaa uuaccgccac gggcagccga uuccgcgcgu ggaguacaug      540

gaggaagaga agaaaaccug ggggaccgug uucaagacac ugaagucgcu cuacaagacu      600

cacgccugcu acgaguacaa ccacaucuuc ccgcugcugg aaaaguacug cggguuucac      660

gaagauaaca ucccgcagcu ggaggacgug ucgcaguucc ugcaaacuug caccggauuc      720

cggcugcggc cgguggcggg gcuccugucc ucccgcgauu uucuuggcgg gcuggcuuuc      780

cggguguucc acugcaccca guauaucaga cacgggucca agccgaugua cacuccggag      840

ccggacaucu gucaugagcu guugggccac gucccgcugu ucuccgaccg gagcuuugcc      900

caguucucac aagaaaucgg acuggcauca cugggggcac ccgaugagua cauugagaag      960

cuugccacca ucuacugguu caccguggaa uucgggcugu guaaacaggg ggacucgauu     1020

aaggcauacg gggccggacu gcucucgucc uucggggaac ugcaauacug ccucucugaa     1080

aagcccaagc uccugccgcu ggagcuggaa aagacugcaa uccagaacua uaccgugacu     1140

gaguuccagc cgcucuacua cgucgcggag uccuucaacg acgcuaagga gaagguccgc     1200

aacuucgcug caaccauccc gcggccguuc agcgugcgcu acgacccgua uacgcagcgc     1260

aucgaggugc uggacaacac ucagcagcug aagauccugg ccgauucaau caacucagaa     1320

aucgggaucc ugugcucggc ccuccaaaag auuaaguaa                            1359


<210>  25
<211>  1359
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Codon-Optimized PAH Coding Sequence

<400>  25
augucaaccg cugugcuuga aaaucccgga cucggccgca aguuauccga uuuuggacaa       60

gaaaccucau acauugagga caacugcaac cagaacggcg cgaucucacu gaucuucucg      120

cugaaagagg aagucggagc auuggccaag guccugaggc uguucgagga aaacgacgug      180

aaccugaccc acauagaauc gcggccguca cggcuaaaga aggaugaaua cgaguucuuc      240

acccaccugg acaagcgguc gcugccggcg cugacuaaca ucaucaagau ucugcggcac      300

gauaucgggg caaccgugca ugagcugagc cgggacaaga agaaggacac cgugccgugg      360

uucccccgga cuauccagga gcuggaccgc uucgcgaacc aaauccugag cuacggugca      420

gaacuggacg cggaccaccc aggguucaag gacccggugu acagagccag gagaaagcag      480

uucgccgaca uugcauacaa cuaccgccac ggccagccga uuccccgcgu ggaguacaug      540

gaagaagaga agaaaaccug gggaacugug uucaagacuc ugaagucccu guauaagacc      600

cacgccuguu augaguacaa ccauauuuuc ccgcugcugg aaaaguauug cggauuccau      660

gaggauaaca uuccgcagcu ggaggacgug ucacaguuuc ugcaaacuug caccggauuc      720

cggcugaggc cggucgccgg auuguugucc ucccgggauu uccucggcgg acuggcauuc      780

agaguguucc acugcaccca guacauuaga cacgggucga agccgaugua caccccugag      840

ccugacaucu gccaugaacu gcuuggccac gucccguugu uuucggaccg cucauucgca      900

caauucagcc aggagauugg acucgcauca cuuggagccc ccgaugagua caucgagaag      960

cucgccacca ucuacugguu caccguggag uucggccugu gcaaacaggg ggauagcauc     1020

aaagcuuacg gcgcgggccu ccuguccuca uucggggaac uccaguacug ucucuccgaa     1080

aagccgaagc ugcugccccu ugaacucgaa aagaccgcaa uccagaacua caccgugacu     1140

gaauuucagc cgcucuacua cguggccgaa agcuucaacg acgcuaagga aaagguccgc     1200

aacuucgccg cgacuauccc gcgaccguuc uccgugcgcu acgacccaua cacucagcgc     1260

aucgaggugc uggacaauac ccagcagcuc aagauccugg cugacuccau caacucggag     1320

auugggaucc ugugcuccgc ccugcaaaag aucaaguaa                            1359


<210>  26
<211>  1359
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Codon-Optimized PAH Coding Sequence

<400>  26
augucaacug cugugcucga aaaucccggc uuaggaagga agcucucaga cuucggacaa       60

gaaaccuccu acauugagga caacugcaau cagaacggcg caaucucccu gaucuucucg      120

cugaaagaag aagucggcgc acuugccaag guccugagac ucuucgagga aaacgacgug      180

aaccucaccc acaucgaguc acgcccgucg agauugaaga aggaugagua cgaguucuuc      240

acccaucuug auaagcgguc gcugcccgca cuuaccaaca uuaucaagau ccugcggcau      300

gacauuggag caaccgugca cgaacugucc cgcgacaaga agaaagauac cgugccgugg      360

uucccgagaa ccauucagga gcuggaccgg uucgccaacc aaauccuguc cuacggggcc      420

gaacuggaug ccgaucaccc gggguucaag gacccggucu accgcgcgcg gcgcaagcag      480

uuugcugaua uugccuacaa cuaccgccac ggccagccga ucccgcgagu ggaguacaug      540

gaagaagaga agaaaaccug gggcacugug uucaagaccc ugaagucgcu cuauaagacg      600

cacgccugcu acgaguacaa ccacaucuuc ccgcuccugg agaaguacug cggguuucac      660

gaggauaaca ucccgcaacu ggaggacguc agccaguucc ugcaaaccug uaccggauuc      720

aggcugaggc cgguggccgg acugcucuca ucacgcgacu uccugggggg ccucgcguuc      780

cggguguucc auugcacaca guacauuaga cacgggucga agccgaugua cacccccgag      840

ccggacaucu gccacgagcu gcugggacau gugccgcugu ucuccgaccg gagcuucgcu      900

caguucagcc aggaaaucgg gcuggcgucg cucggagcac cggaugagua cauagagaag      960

cuggcuacua ucuacugguu caccguggag uucggccugu gcaaacaggg ggacucaauc     1020

aaggcguacg gagccgguuu gcugagcuca uucggagaac uacaguauug ucuguccgaa     1080

aagccgaagc uucugccgcu ggaacuggaa aagaccgcaa uccagaacua uaccgugacu     1140

gaguuccagc cccuguacua cguggcagaa uccuucaacg acgccaagga gaagguccgc     1200

aacuuugccg cgacuauccc ccggccguuc ucugugcgcu acgacccgua cacucagcgg     1260

aucgaagugu uggacaacac ccagcaguug aagauucugg cagacagcau caacucggaa     1320

auugggauuc ugugcuccgc gcuccaaaag aucaaguaa                            1359


<210>  27
<211>  1359
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Codon-Optimized PAH Coding Sequence

<400>  27
augucaaccg ccgugcucga aaauccagga uugggaagaa aacucucaga cuucggccag       60

gaaaccucgu acauugagga uaacuguaac cagaacggcg cgaucucgcu gaucuuuagc      120

cugaaggagg aagucggagc acuggccaag guccugaggc uguucgaaga gaacgacgug      180

aaccugacuc auauugaaag ccgcccguca cgccugaaga aagaugagua ugaguucuuc      240

acccaccugg acaagcgcag ccugccggcc cucacuaaca ucaucaagau ccuaagacac      300

gauauuggag cgaccgucca cgaauuguca agggacaaga agaaggacac ugucccgugg      360

uucccgagaa ccauucagga gcucgaccgg uucgcaaacc aaaucuuauc cuacggagcu      420

gaacuggacg cagaccaccc gggguucaag gaccccgugu accgggcgcg caggaagcag      480

uucgcugaca ucgcauacaa cuaccgccac gggcagccga uaccgcgcgu ggaguauaug      540

gaagaagaga agaaaaccug ggggacggug uucaagacuc ugaagucccu cuacaaaacc      600

cacgccugcu acgaguacaa ccauauuuuu ccgcuccugg aaaaguacug cggcuuccau      660

gaggacaaca ucccacagcu ggaagaugug ucacaguuuc ugcaaacuug uaccggcuuc      720

cggcugcggc caguggcagg ccugcucucc ucccgcgauu uccucggcgg ucuggcguuc      780

cggguguucc acugcaccca guacaucaga cauggaucga agccgaugua cacucccgaa      840

ccugacaucu gccacgagcu guugggacau gugcccuugu ucucggaucg gagcuucgcg      900

caguucucac aagagauugg ccuugcguca cugggagcac cggacgagua caucgagaag      960

cucgcaacca ucuacugguu caccgucgaa uucggccugu gcaagcaggg agacucgauu     1020

aaggccuacg gggccggacu gcugucgucc uucggggagc ugcaguacug ccuguccgaa     1080

aagccgaagc uucugccccu ggaauuggaa aagacagcca uccagaacua caccgugacc     1140

gaauuccagc cccucuacua cguggcugaa uccuucaacg acgccaagga gaagguccgc     1200

aacuuugcug cgaccauccc gcggccuuuc uccgugcgau acgauccgua uacccagcgg     1260

aucgaggugc uggacaacac ccagcaacuu aagauccugg ccgacuccau caauagcgag     1320

auuggaaucc ugugcagcgc ccugcaaaag aucaaguaa                            1359


<210>  28
<211>  1359
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Codon-Optimized PAH Coding Sequence

<400>  28
augucaaccg ccguccuuga aaaccccggc cucggaagaa agcucucaga cuuuggacag       60

gaaacuuccu acauugagga uaacugcaac cagaacggug caaucagccu gaucuucucg      120

cugaaagagg aagucggggc acuggcaaag guccugcgcc uguucgagga aaaugaugug      180

aaccugacuc auaucgaguc acggccgucg cgccucaaga aggacgaaua cgaguucuuc      240

acccaccuug acaagagauc ccuuccggca cugacuaaca ucaucaagau uuugcggcac      300

gacauugggg ccaccgugca cgaacugucu agggacaaaa agaaggauac ugucccgugg      360

uucccgcgga cuauucagga acuggaccgc uucgcgaacc aaauucugag cuacggggcu      420

gaacuagaug cggaccaccc gggcuuuaag gauccggugu accgcgcacg gcgaaagcaa      480

uucgccgaua uugccuauaa cuaccgccac ggacagccga ucccacgcgu ggaguacaug      540

gaggaagaga aaaagaccug gggcaccgug uucaagaccc ugaagucgcu guacaagacc      600

cacgcaugcu acgaguacaa ccacaucuuc ccgcugcugg aaaaguacug cggguuccac      660

gaggacaaca uuccgcaacu ggaggacgug ucccaguuuc uccaaaccug uaccggguuc      720

agacugaggc ccguggcugg acugcugucg ucccgggacu uccugggggg ccucgccuuc      780

cgcguguucc auugcacuca guacauccgc cacgggucaa agccgaugua caccccugag      840

cccgauaucu gucaugaguu gcugggccau gugccucucu ucuccgaucg gucguucgcg      900

caguuuagcc aggaaauugg guuggcuucg cucggagccc cagacgagua caucgagaag      960

cuggcuacga ucuacugguu caccguggag uucggccugu gcaaacaggg agacuccaua     1020

aaggccuaug gcgcgggacu ccuguccuca uucggagagc ugcaguacug cuuauccgag     1080

aagcccaagc uccucccgcu ugaacuggaa aagaccgcaa uccagaacua caccgugacg     1140

gaguuccagc cgcuguauua cguggccgaa ucguucaacg acgcaaagga aaagguccgc     1200

aauuucgcgg cgacaauccc gcggccguuc ucagugcgcu acgacccgua cacucagcgg     1260

aucgaagugc uggacaacac ccagcaacuu aagauccugg ccgacucaau caacuccgaa     1320

aucggaaucc ugugcagcgc acugcagaag auuaaguaa                            1359


<210>  29
<211>  1359
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Codon-Optimized PAH Coding Sequence

<400>  29
augucaaccg cugugcuuga aaaccccgga cucggccgca aguuaucuga uuucggacaa       60

gaaacuucau acauugagga caacugcaac cagaacgggg cgauuucacu gaucuucucg      120

cugaaagaag aagucggagc auuggcgaag guccugaggc uguucgagga aaacgacgug      180

aaccugaccc acauagaauc gcggccguca cggcuaaaga aggaugaaua cgaguucuuc      240

acgcaccugg acaagcgguc gcugccggcg cugaccaaca ucaucaagau ucugcggcac      300

gauaucgggg caaccgugca ugagcugagc cgggacaaga agaaggacac cgugccuugg      360

uuuccccgga caauccagga gcuggaccgc uucgccaauc aaauccugag cuacggugca      420

gaacuggacg cggaccaccc aggguucaag gacccggugu acagagccag gagaaagcag      480

uucgccgaua uugcauacaa cuaccgccac ggccagccga uuccccgcgu ggaguacaug      540

gaagaagaga agaaaaccug ggggaccgug uucaagacuc ugaagucccu guauaagacc      600

cacgcguguu augaguacaa ccauaucuuc ccgcugcugg aaaaguauug cggauuccau      660

gaggauaaca uuccgcagcu ggaggacgug ucacaguuuc ugcaaacuug caccggauuc      720

cggcugaggc cggucgccgg auugcucucc ucccgggauu uccucggcgg acuggcauuc      780

agaguguucc acugcaccca guacauuaga cacgggucga agccgaugua caccccugag      840

ccugacaucu gccaugaacu gcuuggccac gucccguugu uuucggaccg cucauucgca      900

caauucagcc aggagauugg acucgcauca cuuggagccc ccgaugagua caucgagaag      960

cucgccacca ucuacugguu cacuguggag uucggccugu gcaaacaggg ggauuccauc     1020

aaagcuuacg gcgcgggccu ccuguccuca uucggggagu ugcaguacug ucucuccgaa     1080

aagccgaagc ugcugccccu ugaacucgaa aagaccgcaa uccagaacua caccgugacu     1140

gaauuucagc cgcucuacua cguggccgag agcuucaacg acgcuaagga aaagguccgc     1200

aacuucgccg ccacuauccc acgaccguuc uccgugcgcu acgacccaua cacucagcgc     1260

aucgaggugc uggacaauac ccagcagcuc aagauccugg cugacuccau caacucggag     1320

auugggaucc ugugcucggc ccugcaaaag aucaaguaa                            1359


<210>  30
<211>  1359
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Codon-Optimized PAH Coding Sequence

<400>  30
augucaaccg cugugcuuga aaaccccgga cucggccgca agcuuucuga uuucggacaa       60

gaaaccucau acauugagga caacugcaac cagaacgggg cgaucucacu gaucuucucg      120

cugaaagaag aagucggagc auuggcgaag guccugaggc uguucgagga aaacgacgug      180

aaccugaccc acauagaauc gcgcccguca cggcuaaaga aggaugaaua cgaguucuuc      240

acgcaccugg acaagagauc acugccggcg cugacuaaca ucaucaagau ucugcggcac      300

gauauugggg caaccgugca ugagcugagc cgggacaaga agaaggacac cgugccgugg      360

uuuccccgga caauccagga gcuggaucgg uucgccaauc aaauccugag cuacggugca      420

gaacuggacg cggaccaccc aggguucaag gacccggugu accgggccag gagaaagcag      480

uucgccgaua ucgcauacaa cuaccgccac ggccagccga uuccccgcgu ggaguacaug      540

gaagaagaga agaaaaccug ggggacugug uucaagacuc ugaagucgcu guauaagacc      600

cacgcguguu augaguacaa ccacauuuuc ccgcugcugg aaaaguauug cggauuccau      660

gaggauaaca uuccgcagcu ggaggacgug ucacaguuuc ugcaaacuug caccggauuc      720

cggcugaggc cggucgccgg auugcugucc ucccgggauu uccucggcgg acuggcauuc      780

agaguguucc auugcaccca guacauuaga cacgggucga agccgaugua caccccugag      840

ccugacaucu gccaugaacu gcuuggccac gucccguugu uuucggaccg cucauucgca      900

caauucagcc aggagauugg acuggcaucc cuuggagccc ccgacgagua caucgagaag      960

cuggccacca ucuacugguu caccguggag uucggccugu gcaaacaggg ggauuccauc     1020

aaagcuuacg gcgcgggccu ccuuuccuca uucggggaau ugcaguacug ucuguccgaa     1080

aagccgaagc ugcugccccu ugaacucgaa aagaccgcaa uccagaacua caccgugacu     1140

gaauuucagc cgcucuacua cguggccgag agcuucaacg acgcuaagga aaagguccgc     1200

aacuucgccg ccacuauccc gcgaccguuc uccgugcgcu acgacccaua cacucagcgc     1260

aucgaggugc uggacaauac ccagcagcug aagauccugg cugacuccau caacucggag     1320

auugggaucc ugugcucggc ccugcaaaag aucaaguaa                            1359


<210>  31
<211>  1359
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Codon-Optimized PAH Coding Sequence

<400>  31
augucaaccg cugugcuuga aaaccccgga cucggccgca aguuaucuga uuucggacaa       60

gaaaccucau acaucgagga caacugcaac cagaacgggg cgaucucacu gaucuucucg      120

cugaaagaag aagucggagc auuggcgaag guccugaggc uguucgagga aaacgacgug      180

aaccugaccc acauagaauc gcggccguca cggcuaaaga aggaugaaua cgaguucuuc      240

acgcaccugg acaagcgguc gcugccggcg cugacuaaca ucaucaagau ucuccggcac      300

gauaucgggg caaccgugca ugagcugagc cgggacaaga agaaggauac cgugccgugg      360

uuuccccgga caauucagga acuggaccgc uucgccaauc aaauccugag cuacggugca      420

gaacuggacg cggaccaccc aggguucaag gacccggugu acagagccag gagaaagcag      480

uucgccgaca uugcauacaa cuaccgccac gggcagccga uuccccgcgu ggaguacaug      540

gaggaagaga agaaaaccug ggggacugug uucaagacuc ugaagucccu guauaagacc      600

caugcguguu augaguacaa ccacauuuuc ccgcugcugg aaaaguauug cggguuccau      660

gaggauaaca uuccgcagcu ggaggacgug ucacaguuuc ugcaaacuug caccggguuc      720

cggcugaggc cggucgccgg auugcucucc ucccgggauu uccucggggg gcuggcauuc      780

agaguguucc acugcaccca guacauuaga cacgggucga agccgaugua caccccugag      840

ccugacaucu gccaugaacu gcuuggccac gucccguugu uuucggaccg cucauucgca      900

caauucagcc aggagauugg acucgcauca cuuggagccc ccgaugagua caucgagaag      960

cucgccacca ucuacugguu caccguggag uucgggcugu gcaaacaggg ggauuccauc     1020

aaagcuuacg gcgcggggcu ccuguccuca uucggggaau ugcaguacug ucucuccgaa     1080

aagccgaagc ugcugccccu ugaacucgaa aagaccgcaa uccagaacua caccgugacu     1140

gaguuucagc cgcucuacua cguggccgag agcuucaacg acgcuaagga aaagguccgc     1200

aacuucgccg ccacuauccc gcgaccguuc uccgugcgcu acgacccaua cacucagcgc     1260

aucgaagugc uggacaauac ccagcagcuc aagauccugg cugacuccau caacucggag     1320

auugggaucc ugugcucggc ccugcaaaag aucaaguaa                            1359


<210>  32
<211>  1359
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Codon-Optimized PAH Coding Sequence

<400>  32
augucaacug cugugcucga aaacccaggc cuuggaagga agcugucaga cuucggacaa       60

gaaaccuccu acauugagga caacuguaac cagaacggcg ccaucucccu cauuuucuca      120

cugaaagagg aagucggggc gcuggcgaag guccugagac uguuugaaga aaacgacgug      180

aaccugaccc acauugaguc ccgaccuucg cgccucaaga aggacgaaua cgaauucuuc      240

acccaucugg acaagcgcuc ccugccggca cuuaccaaua ucaucaagau ccugcggcau      300

gauaucggcg cuaccgugca ugagcugucu cgggauaaga agaaggacac cgugcccugg      360

uucccgagaa ccauccagga acuugaucgg uucgccaacc aaauucuguc cuacggggcc      420

gaacuggaug cagaucaccc ggguuucaag gacccugugu accgggcccg gcggaagcaa      480

uucgccgaca uugcauacaa cuauagacau ggacagccca uuccgagggu ggaguacaug      540

gaggaggaga aaaagacuug gggaacugug uucaagaccc ugaagucguu guauaagacu      600

cacgcuugcu acgaguacaa ccacaucuuc ccgcugcugg agaaguacug cggguuccac      660

gaggacaaca uuccgcaacu ugaggacguc agccaguucc ugcaaaccug uacuggauuc      720

cgccugcgcc cgguggccgg ccugcuguca ucacgggacu uccugggagg ccucgcguuc      780

cgcguguucc acugcaccca guacaucaga cacggaucca agccgaugua cacccccgaa      840

ccggauauuu gccacgaguu gcugggccac gugccacugu uuagcgaccg cagcuucgca      900

caguucagcc aggaaaucgg gcuggcuucc cuuggcgccc cggaugagua caucgaaaag      960

cuugcaacca ucuacugguu cacugucgaa uucgggcugu gcaaacaggg ggacucaauc     1020

aaggcauacg gggcgggauu gcucucgucg uuuggcgaac ugcaguacug ccuuucggaa     1080

aagcccaagu ugcugccccu ggaacuggag aaaaccgcaa uccagaacua uacugugacc     1140

gaauuccagc cacuguacua cguggccgag ucauucaacg acgcgaagga gaaaguccgc     1200

aauuucgcug cgacuauccc gcggccguuc uccgugcgcu acgacccgua cacccagcgc     1260

auagaggugc uggauaacac ccagcagcua aagauccugg ccgacucgau caacucggaa     1320

aucggaaucc ugugcagcgc acugcagaag auuaaguaa                            1359


<210>  33
<211>  1359
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Codon-Optimized PAH Coding Sequence

<400>  33
augucaaccg cugugcuuga aaaccccgga cucggccgca aguuaucuga uuucggacaa       60

gaaaccuccu acaucgagga caacugcaac cagaacgggg cgauuucacu gaucuucucg      120

cugaaagaag aagucggggc auuggcgaag guccugaggc uguucgagga aaacgacgug      180

aaccugaccc acauagaauc gcggccguca cggcuaaaga aggaugaaua cgaguucuuc      240

acgcaccugg acaagcgguc gcugccggca cugacuaaca ucaucaagau ucugcggcau      300

gauaucgggg ccaccgugca ugagcugagc cgggacaaga agaaggacac cgugccgugg      360

uuuccccgga caauccagga acuggaccgc uucgccaauc aaauccugag cuacggugca      420

gaacuggacg cggaccaccc gggguucaag gacccggugu accgggccag gagaaagcag      480

uucgccgaua uugcauacaa cuaccgccac gggcagccga uuccccgcgu ggaguacaug      540

gaagaagaga agaaaaccug ggggacugug uucaagaccc ugaagucccu guauaagacc      600

cacgcguguu augaguacaa ccacauuuuc ccgcugcugg aaaaguauug cggauuccau      660

gaggauaaca uuccgcaacu ggaggaugug ucacaguucc ugcaaacuug cacuggauuc      720

agacugaggc cggucgccgg gcugcucuca ucccgggacu uccucggggg gcuggcauuc      780

agaguguucc acugcaccca guacauuaga cacgggucga agccgaugua caccccggag      840

ccggacaucu gccaugaguu gcuuggccac gucccguugu uuucggaccg cucauucgcc      900

caauucagcc aggagauugg gcucgcguca cuuggagcac ccgaugagua caucgagaag      960

cucgccacca ucuacugguu caccguggag uucgggcugu gcaaacaggg ggauuccauc     1020

aaagcuuacg gcgcgggacu ccuguccuca uucggggagu ugcaguacug ucucuccgaa     1080

aagccgaagc ugcugccccu ugaacucgaa aagaccgcaa uccagaacua caccgugacu     1140

gaauuucagc cgcucuacua cguggccgag agcuucaacg acgcuaagga gaagguccgc     1200

aacuucgccg caacuauccc gcgaccguuu uccgugcgcu acgacccgua cacucagcgc     1260

aucgaagugc uggacaauac gcagcagcuc aagauccugg cugacuccau caacucggag     1320

auugggaucc ugugcucggc ccugcaaaag aucaaguaa                            1359


<210>  34
<211>  1359
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Codon-Optimized PAH Coding Sequence

<400>  34
augucaaccg cugugcuuga aaacccugga cucggccgca agcuuuccga uuuuggacaa       60

gaaaccucau acauugagga caacugcaac cagaacgggg cgaucucacu gaucuucucg      120

cugaaagaag aggucggagc acuggcgaaa guccugaggc uguucgagga aaacgacgug      180

aaccugaccc acauagaauc acggccgucg cggcuaaaga aggaugaaua cgaguucuuc      240

acccaccugg acaagcgguc ccugccggcc cuuacuaaca ucaucaagau ucugcggcac      300

gauaucgggg caaccgugca ugagcugagc cgggacaaga agaaggacac cgugccgugg      360

uuuccccgga cuauccagga guuggaccgc uucgccaauc aaauccugag cuacggugca      420

gaacuggacg cggaccaccc aggguucaag gacccagugu auagagccag gagaaagcag      480

uucgccgaua uugcauacaa cuaccgccac ggccagccga uuccccgcgu ggaguacaug      540

gaagaggaga agaaaaccug ggggacugug uucaagacuc ugaagucccu guauaagacc      600

cacgcguguu acgaguacaa ccauaucuuc ccgcugcugg aaaaguacug cggauuccau      660

gaggauaaca uuccgcagcu ggaggacgug ucacaguucc ugcaaacuug caccggauuc      720

cggcugaggc cggucgccgg auugcugucc ucccgggauu uccucggcgg acuggcauuc      780

agaguguucc acugcaccca guacauuaga cacgggucga agccgaugua caccccugag      840

ccugacaucu gccaugaacu gcuuggccac gucccguugu uuucggaccg cucauucgca      900

caauucagcc aggagauugg gcucgcauca cuuggagcac ccgaugagua caucgagaag      960

cucgccacca ucuacugguu caccguggag uucggccugu gcaaacaggg ggauuccauc     1020

aaggcuuacg gcgcgggccu gcuguccuca uucggggaac ugcaguacug ucuguccgaa     1080

aagccgaagu ugcugccccu ugaacucgaa aagaccgcaa uccagaacua caccgugacu     1140

gaauuucagc cgcuuuacua cguggccgag agcuucaacg acgcuaagga aaagguccgc     1200

aacuucgccg cgacuauccc ccgaccguuc uccgugcgcu augacccaua cacucagcgc     1260

aucgaggugc uggacaauac ccagcagcug aagauccugg cugacucgau caacuccgag     1320

aucggaaucc ugugcagcgc ccugcaaaag auuaaguaa                            1359


<210>  35
<211>  1359
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Codon-Optimized PAH Coding Sequence

<400>  35
auguccaccg ccgugcuuga aaauccuggg uuggguagaa aacugucaga uuuuggccaa       60

gaaaccucau acaucgaaga uaacugcaac cagaauggag cuaucucccu gauauucucg      120

cugaaagagg aagucggcgc ccuggccaaa guucugagac ucuucgagga aaacgacguu      180

aaccugacuc acauugaauc ccggcccucc cgacugaaga aggaugaaua cgaauucuuc      240

acucaccugg acaagagguc ccugccggcc cugaccaaca ucauuaagau ccugcggcac      300

gacaucgggg ccaccgugca cgaacugagc agggacaaga agaaggauac cgugcccugg      360

uuuccgcgca cuauucaaga acuggacaga uuugccaacc aaauucuguc cuacggggcc      420

gaacuggacg ccgaucaccc cggguuuaag gaccccgugu accgggcccg gcgcaagcag      480

uuugcggaca ucgcuuauaa cuaucggcau ggccagccga ucccccgugu ggaguacaug      540

gaagaggaga aaaagacuug gggcaccgua uucaagaccc uaaagagccu guauaagacc      600

caugccuguu acgaguacaa ccacaucuuc ccguugcugg aaaaguacug uggauuucac      660

gaggauaaca uaccccagcu ugaggacguc agccaguucc ugcaaacuug uaccggguuc      720

aggcugaggc cgguugccgg gcugcugagc ucacgggacu uccugggagg ucuggcauuc      780

cggguguucc auugcaccca guacaucaga caugggucca agcccaugua uaccccggaa      840

ccggauaucu gucacgagcu gcuuggacau gugccgcuuu ucuccgaccg aagcuucgcc      900

caguucagcc aagaaauagg gcucgccagu cugggcgccc cggaugagua caucgaaaag      960

uuggcgacca ucuacugguu cacuguagag uucggccuuu gcaaacaagg ggacagcauc     1020

aaggcauacg gggccgguuu guugucgagc uucggggagc ugcaguauug ucuguccgaa     1080

aagccgaaac uccugccgcu ggaguuggaa aagacagcua uucagaacua uacagugaca     1140

gaauuucagc cccuguacua cguggcagaa uccuucaacg acgcgaagga gaaaguccgg     1200

aauuuugccg cuaccauucc gcgcccguuu uccgugcgcu acgacccgua cacucagaga     1260

auugaggugc uggacaauac ccagcagcuu aagauucugg cggacucaau caacagcgag     1320

auuggcaucc ugugcuccgc acugcaaaag aucaaguaa                            1359


<210>  36
<211>  1359
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Codon-Optimized PAH Coding Sequence

<400>  36
augucaacug cugugcucga aaaccccggc cuaggaagaa aacugucaga uuucggccaa       60

gagacuuccu acauugagga caacugcaau cagaacggag caaucucccu gaucuucuca      120

cugaaagagg aagucggggc acuugccaag guccuccgcc uguuugagga aaacgacgug      180

aacuugaccc acaucgaguc gcgcccgucg cgccugaaga aggacgaaua cgaauucuuc      240

acccaccugg acaagcgguc acucccggcg cugaccaaca uaaucaagau ccuucggcac      300

gacauuggag ccaccgugca cgaauugucg cgggacaaga agaaggacac cgugccgugg      360

uucccgagga ccauucagga gcuggaccgg uucgcaaacc agauccucuc cuacggggca      420

gaacuggaug ccgaucaccc gggcuucaag gaccccgugu accgggccag gcgcaagcag      480

uucgccgaca uugccuacaa cuaccgccac gggcagccga uuccgagggu ggaguauaug      540

gaagaggaaa agaaaaccug ggggaccgug uucaagaccc uuaagucacu guacaagacu      600

caugccugcu acgaguacaa ccacaucuuc ccgcugcugg agaaguauug cggguuucau      660

gaggacaaua ucccgcaacu ugaggacguc agccaguucc ugcaaacuug caccggguuc      720

agacugcggc cgguggcagg acugcugucc ucgcgggacu uccugggggg ccuggcguuc      780

cgcguguucc acugcaccca guacauuaga cacgguucca agccgaugua caccccggaa      840

ccggacaucu gccaugaacu guugggacac gugccccugu uuuccgaucg gucguucgca      900

caauucagcc aggaaaucgg gcucgccuca cugggggccc cggaugagua caucgagaag      960

cuggcgacca ucuacugguu uacugucgaa uucggccugu guaaacaggg ggauucgauc     1020

aaggcguacg gggccggccu gcugucguca uucggagagc ugcaguacug ucugagcgag     1080

aagccgaagc uccuuccccu ugaacuggaa aagaccgcaa uccagaacua caccgugacu     1140

gaauuccaac cgcuguacua uguggcugag uccuucaacg acgcgaagga aaaaguccga     1200

aacuucgcgg cgacuauccc ccggcccuuc uccgugcgcu acgacccgua cacucagcgc     1260

auugaagugc ucgacaacac ccagcagcug aagauccugg ccgauucaau caacuccgaa     1320

auuggaaucc ugugcagcgc auugcagaag auuaaguaa                            1359


<210>  37
<211>  1359
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Codon-Optimized PAH Coding Sequence

<400>  37
auguccaccg ccgugcugga gaaccccggc uugggcagga agcuguccga cuucggccag       60

gagaccagcu acaucgagga caacugcaac cagaacggcg ccaucucccu gaucuucucc      120

cugaaggagg aggugggcgc cuuggccaag guguugcggu uguucgagga gaacgacgug      180

aaccugaccc acaucgaguc caggcccucc cgguugaaga aggacgagua cgaguucuuc      240

acccacuugg acaagcggag ccugcccgcc cugaccaaca ucaucaagau cuugaggcac      300

gacaucggcg ccaccgugca cgagcugucc cgggacaaga agaaggacac cgugcccugg      360

uuccccagga ccauccagga gcuggacagg uucgccaacc agauccugag cuacggcgcc      420

gagcuggacg ccgaccaccc cggcuucaag gaccccgugu accgggccag gcggaagcag      480

uucgccgaca ucgccuacaa cuaccggcac ggccagccca ucccccgggu ggaguacaug      540

gaggaggaga agaagaccug gggcaccgug uucaagaccc ugaaguccuu guacaagacc      600

cacgccugcu acgaguacaa ccacaucuuc ccccugcugg agaaguacug cggcuuccac      660

gaggacaaca ucccccagcu ggaggacgug ucccaguucc ugcagaccug caccggcuuc      720

cggcugcggc ccguggccgg ccugcugucc ucccgggacu ucuugggcgg ccuggccuuc      780

cggguguucc acugcaccca guacaucagg cacggcucca agcccaugua cacccccgag      840

cccgacaucu gccacgagcu guugggccac gugcccuugu ucuccgaccg gagcuucgcc      900

caguucuccc aggagaucgg ccuggccucc cugggcgccc ccgacgagua caucgagaag      960

cuggccacca ucuacugguu caccguggag uucggccugu gcaagcaggg cgacuccauc     1020

aaggccuacg gcgccggccu gcuguccucc uucggcgagu ugcaguacug cuuguccgag     1080

aagcccaagc ugcugccccu ggagcuggag aagaccgcca uccagaacua caccgugacc     1140

gaguuccagc cccuguacua cguggccgag agcuucaacg acgccaagga gaaggugagg     1200

aacuucgccg ccaccauccc ccggcccuuc uccgugcggu acgaccccua cacccagagg     1260

aucgaggugu uggacaacac ccagcagcug aagaucuugg ccgacuccau caacagcgag     1320

aucggcaucc ugugcagcgc ccugcagaag aucaaguaa                            1359


<210>  38
<211>  158
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Modified Xenopus beta-globin 3UTR


<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  n is unlocked nucleomonomer UNA-U

<220>
<221>  misc_feature
<222>  (157)..(157)
<223>  n is unlocked nucleomonomer UNA-A

<400>  38
cnagugacug acuaggaucu gguuaccacu aaaccagccu caagaacacc cgaauggagu       60

cucuaagcua cauaauacca acuuacacuu acaaaauguu gucccccaaa auguagccau      120

ucguaucugc uccuaauaaa aagaaaguuu cuucacnu                              158


<210>  39
<211>  158
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Modified Xenopus beta-globin 3UTR


<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  n is unlocked nucleomonomer UNA-U

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  n is unlocked nucleomonomer UNA-A

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  n is unlocked nucleomonomer UNA-G

<220>
<221>  misc_feature
<222>  (155)..(155)
<223>  n is unlocked nucleomonomer UNA-A

<220>
<221>  misc_feature
<222>  (156)..(156)
<223>  n is unlocked nucleomonomer UNA-C

<220>
<221>  misc_feature
<222>  (157)..(157)
<223>  n is unlocked nucleomonomer UNA-A

<400>  39
cnnnugacug acuaggaucu gguuaccacu aaaccagccu caagaacacc cgaauggagu       60

cucuaagcua cauaauacca acuuacacuu acaaaauguu gucccccaaa auguagccau      120

ucguaucugc uccuaauaaa aagaaaguuu cuucnnnu                              158


<210>  40
<211>  158
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Modified Xenopus beta-globin 3UTR


<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  n is unlocked nucleomonomer UNA-U

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  n is unlocked nucleomonomer UNA-C

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  n is unlocked nucleomonomer UNA-A

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  n is unlocked nucleomonomer UNA-U

<220>
<221>  misc_feature
<222>  (26)..(26)
<223>  n is unlocked nucleomonomer UNA-C

<220>
<221>  misc_feature
<222>  (32)..(32)
<223>  n is unlocked nucleomonomer UNA-A

<220>
<221>  misc_feature
<222>  (38)..(38)
<223>  n is unlocked nucleomonomer UNA-C

<220>
<221>  misc_feature
<222>  (44)..(44)
<223>  n is unlocked nucleomonomer UNA-G

<220>
<221>  misc_feature
<222>  (50)..(50)
<223>  n is unlocked nucleomonomer UNA-C

<220>
<221>  misc_feature
<222>  (56)..(56)
<223>  n is unlocked nucleomonomer UNA-G

<220>
<221>  misc_feature
<222>  (62)..(62)
<223>  n is unlocked nucleomonomer UNA-U

<220>
<221>  misc_feature
<222>  (68)..(68)
<223>  n is unlocked nucleomonomer UNA-C

<220>
<221>  misc_feature
<222>  (74)..(74)
<223>  n is unlocked nucleomonomer UNA-A

<220>
<221>  misc_feature
<222>  (80)..(80)
<223>  n is unlocked nucleomonomer UNA-A

<220>
<221>  misc_feature
<222>  (86)..(86)
<223>  n is unlocked nucleomonomer UNA-C

<220>
<221>  misc_feature
<222>  (92)..(92)
<223>  n is unlocked nucleomonomer UNA-C

<220>
<221>  misc_feature
<222>  (98)..(98)
<223>  n is unlocked nucleomonomer UNA-G

<220>
<221>  misc_feature
<222>  (104)..(104)
<223>  n is unlocked nucleomonomer UNA-C

<220>
<221>  misc_feature
<222>  (110)..(110)
<223>  n is unlocked nucleomonomer UNA-A

<220>
<221>  misc_feature
<222>  (116)..(116)
<223>  n is unlocked nucleomonomer UNA-G

<220>
<221>  misc_feature
<222>  (122)..(122)
<223>  n is unlocked nucleomonomer UNA-C

<220>
<221>  misc_feature
<222>  (128)..(128)
<223>  n is unlocked nucleomonomer UNA-U

<220>
<221>  misc_feature
<222>  (134)..(134)
<223>  n is unlocked nucleomonomer UNA-U

<220>
<221>  misc_feature
<222>  (140)..(140)
<223>  n is unlocked nucleomonomer UNA-A

<220>
<221>  misc_feature
<222>  (146)..(146)
<223>  n is unlocked nucleomonomer UNA-A

<220>
<221>  misc_feature
<222>  (152)..(152)
<223>  n is unlocked nucleomonomer UNA-U

<220>
<221>  misc_feature
<222>  (157)..(157)
<223>  n is unlocked nucleomonomer UNA-A

<400>  40
cnaguganug acunggaucn gguuancacu anaccagncu caanaacacn cgaaungagu       60

cncuaagnua caunauaccn acuuanacuu anaaaaunuu gucncccaan auguanccau      120

unguaucngc uccnaauaan aagaanguuu cnucacnu                              158


<210>  41
<211>  158
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Modified Xenopus beta-globin 3UTR


<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  n is unlocked nucleomonomer UNA-U

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  n is unlocked nucleomonomer UNA-A

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  n is unlocked nucleomonomer UNA-C

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  n is unlocked nucleomonomer UNA-U

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  n is unlocked nucleomonomer UNA-A

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  n is unlocked nucleomonomer UNA-G

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  n is unlocked nucleomonomer UNA-U

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  n is unlocked nucleomonomer UNA-G

<220>
<221>  misc_feature
<222>  (26)..(27)
<223>  n is unlocked nucleomonomer UNA-C

<220>
<221>  misc_feature
<222>  (32)..(33)
<223>  n is unlocked nucleomonomer UNA-A

<220>
<221>  misc_feature
<222>  (38)..(39)
<223>  n is unlocked nucleomonomer UNA-C

<220>
<221>  misc_feature
<222>  (44)..(44)
<223>  n is unlocked nucleomonomer UNA-G

<220>
<221>  misc_feature
<222>  (45)..(45)
<223>  n is unlocked nucleomonomer UNA-A

<220>
<221>  misc_feature
<222>  (50)..(51)
<223>  n is unlocked nucleomonomer UNA-C

<220>
<221>  misc_feature
<222>  (56)..(57)
<223>  n is unlocked nucleomonomer UNA-G

<220>
<221>  misc_feature
<222>  (62)..(62)
<223>  n is unlocked nucleomonomer UNA-U

<220>
<221>  misc_feature
<222>  (63)..(63)
<223>  n is unlocked nucleomonomer UNA-C

<220>
<221>  misc_feature
<222>  (68)..(68)
<223>  n is unlocked nucleomonomer UNA-C

<220>
<221>  misc_feature
<222>  (69)..(69)
<223>  n is unlocked nucleomonomer UNA-U

<220>
<221>  misc_feature
<222>  (74)..(75)
<223>  n is unlocked nucleomonomer UNA-A

<220>
<221>  misc_feature
<222>  (80)..(81)
<223>  n is unlocked nucleomonomer UNA-A

<220>
<221>  misc_feature
<222>  (86)..(86)
<223>  n is unlocked nucleomonomer UNA-C

<220>
<221>  misc_feature
<222>  (87)..(87)
<223>  n is unlocked nucleomonomer UNA-A

<220>
<221>  misc_feature
<222>  (92)..(92)
<223>  n is unlocked nucleomonomer UNA-C

<220>
<221>  misc_feature
<222>  (93)..(93)
<223>  n is unlocked nucleomonomer UNA-A

<220>
<221>  misc_feature
<222>  (98)..(98)
<223>  n is unlocked nucleomonomer UNA-G

<220>
<221>  misc_feature
<222>  (99)..(99)
<223>  n is unlocked nucleomonomer UNA-U

<220>
<221>  misc_feature
<222>  (104)..(105)
<223>  n is unlocked nucleomonomer UNA-C

<220>
<221>  misc_feature
<222>  (110)..(111)
<223>  n is unlocked nucleomonomer UNA-A

<220>
<221>  misc_feature
<222>  (116)..(116)
<223>  n is unlocked nucleomonomer UNA-G

<220>
<221>  misc_feature
<222>  (117)..(117)
<223>  n is unlocked nucleomonomer UNA-C

<220>
<221>  misc_feature
<222>  (122)..(122)
<223>  n is unlocked nucleomonomer UNA-C

<220>
<221>  misc_feature
<222>  (123)..(123)
<223>  n is unlocked nucleomonomer UNA-G

<220>
<221>  misc_feature
<222>  (128)..(128)
<223>  n is unlocked nucleomonomer UNA-U

<220>
<221>  misc_feature
<222>  (129)..(129)
<223>  n is unlocked nucleomonomer UNA-G

<220>
<221>  misc_feature
<222>  (134)..(134)
<223>  n is unlocked nucleomonomer UNA-U

<220>
<221>  misc_feature
<222>  (135)..(135)
<223>  n is unlocked nucleomonomer UNA-A

<220>
<221>  misc_feature
<222>  (140)..(141)
<223>  n is unlocked nucleomonomer UNA-A

<220>
<221>  misc_feature
<222>  (146)..(146)
<223>  n is unlocked nucleomonomer UNA-A

<220>
<221>  misc_feature
<222>  (147)..(147)
<223>  n is unlocked nucleomonomer UNA-G

<220>
<221>  misc_feature
<222>  (152)..(153)
<223>  n is unlocked nucleomonomer UNA-U

<220>
<221>  misc_feature
<222>  (157)..(157)
<223>  n is unlocked nucleomonomer UNA-A

<400>  41
cnnguganng acunngaucn nguuannacu annccagnnu caannacacn ngaaunnagu       60

cnnuaagnna caunnuaccn ncuuanncuu annaaaunnu gucnnccaan nuguanncau      120

unnuaucnnc uccnnauaan nagaannuuu cnncacnu                              158


<210>  42
<211>  158
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Modified Xenopus beta-globin 3UTR


<220>
<221>  misc_feature
<222>  (0)..(0)
<223>  n is unlocked nucleomonomer UNA-G

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  n is unlocked nucleomonomer UNA-C

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  n is unlocked nucleomonomer UNA-U

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  n is unlocked nucleomonomer UNA-A

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  n is unlocked nucleomonomer UNA-G

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  n is unlocked nucleomonomer UNA-U

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  n is unlocked nucleomonomer UNA-G

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  n is unlocked nucleomonomer UNA-A

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  n is unlocked nucleomonomer UNA-C

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  n is unlocked nucleomonomer UNA-U

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  n is unlocked nucleomonomer UNA-G

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  n is unlocked nucleomonomer UNA-A

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  n is unlocked nucleomonomer UNA-C

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  n is unlocked nucleomonomer UNA-U

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  n is unlocked nucleomonomer UNA-A

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  n is unlocked nucleomonomer UNA-G

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  n is unlocked nucleomonomer UNA-A

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  n is unlocked nucleomonomer UNA-U

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  n is unlocked nucleomonomer UNA-C

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  n is unlocked nucleomonomer UNA-U

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  n is unlocked nucleomonomer UNA-G

<220>
<221>  misc_feature
<222>  (23)..(24)
<223>  n is unlocked nucleomonomer UNA-U

<220>
<221>  misc_feature
<222>  (25)..(25)
<223>  n is unlocked nucleomonomer UNA-A

<220>
<221>  misc_feature
<222>  (26)..(27)
<223>  n is unlocked nucleomonomer UNA-C

<220>
<221>  misc_feature
<222>  (28)..(28)
<223>  n is unlocked nucleomonomer UNA-A

<220>
<221>  misc_feature
<222>  (29)..(29)
<223>  n is unlocked nucleomonomer UNA-C

<220>
<221>  misc_feature
<222>  (30)..(30)
<223>  n is unlocked nucleomonomer UNA-U

<220>
<221>  misc_feature
<222>  (31)..(33)
<223>  n is unlocked nucleomonomer UNA-A

<220>
<221>  misc_feature
<222>  (34)..(35)
<223>  n is unlocked nucleomonomer UNA-C

<220>
<221>  misc_feature
<222>  (36)..(36)
<223>  n is unlocked nucleomonomer UNA-A

<220>
<221>  misc_feature
<222>  (37)..(37)
<223>  n is unlocked nucleomonomer UNA-G

<220>
<221>  misc_feature
<222>  (38)..(39)
<223>  n is unlocked nucleomonomer UNA-C

<220>
<221>  misc_feature
<222>  (40)..(40)
<223>  n is unlocked nucleomonomer UNA-U

<220>
<221>  misc_feature
<222>  (41)..(41)
<223>  n is unlocked nucleomonomer UNA-C

<220>
<221>  misc_feature
<222>  (42)..(43)
<223>  n is unlocked nucleomonomer UNA-A

<220>
<221>  misc_feature
<222>  (44)..(44)
<223>  n is unlocked nucleomonomer UNA-G

<220>
<221>  misc_feature
<222>  (45)..(46)
<223>  n is unlocked nucleomonomer UNA-A

<220>
<221>  misc_feature
<222>  (47)..(47)
<223>  n is unlocked nucleomonomer UNA-C

<220>
<221>  misc_feature
<222>  (48)..(48)
<223>  n is unlocked nucleomonomer UNA-A

<220>
<221>  misc_feature
<222>  (49)..(51)
<223>  n is unlocked nucleomonomer UNA-C

<220>
<221>  misc_feature
<222>  (52)..(52)
<223>  n is unlocked nucleomonomer UNA-G

<220>
<221>  misc_feature
<222>  (53)..(54)
<223>  n is unlocked nucleomonomer UNA-A

<220>
<221>  misc_feature
<222>  (55)..(55)
<223>  n is unlocked nucleomonomer UNA-U

<220>
<221>  misc_feature
<222>  (56)..(57)
<223>  n is unlocked nucleomonomer UNA-G

<220>
<221>  misc_feature
<222>  (58)..(58)
<223>  n is unlocked nucleomonomer UNA-A

<220>
<221>  misc_feature
<222>  (59)..(59)
<223>  n is unlocked nucleomonomer UNA-G

<220>
<221>  misc_feature
<222>  (60)..(60)
<223>  n is unlocked nucleomonomer UNA-U

<220>
<221>  misc_feature
<222>  (61)..(61)
<223>  n is unlocked nucleomonomer UNA-C

<220>
<221>  misc_feature
<222>  (62)..(62)
<223>  n is unlocked nucleomonomer UNA-U

<220>
<221>  misc_feature
<222>  (63)..(63)
<223>  n is unlocked nucleomonomer UNA-C

<220>
<221>  misc_feature
<222>  (64)..(64)
<223>  n is unlocked nucleomonomer UNA-U

<220>
<221>  misc_feature
<222>  (65)..(66)
<223>  n is unlocked nucleomonomer UNA-A

<220>
<221>  misc_feature
<222>  (67)..(67)
<223>  n is unlocked nucleomonomer UNA-G

<220>
<221>  misc_feature
<222>  (68)..(68)
<223>  n is unlocked nucleomonomer UNA-C

<220>
<221>  misc_feature
<222>  (69)..(69)
<223>  n is unlocked nucleomonomer UNA-U

<220>
<221>  misc_feature
<222>  (70)..(70)
<223>  n is unlocked nucleomonomer UNA-A

<220>
<221>  misc_feature
<222>  (71)..(71)
<223>  n is unlocked nucleomonomer UNA-C

<220>
<221>  misc_feature
<222>  (72)..(72)
<223>  n is unlocked nucleomonomer UNA-A

<220>
<221>  misc_feature
<222>  (73)..(73)
<223>  n is unlocked nucleomonomer UNA-U

<220>
<221>  misc_feature
<222>  (74)..(75)
<223>  n is unlocked nucleomonomer UNA-A

<220>
<221>  misc_feature
<222>  (76)..(76)
<223>  n is unlocked nucleomonomer UNA-U

<220>
<221>  misc_feature
<222>  (77)..(77)
<223>  n is unlocked nucleomonomer UNA-A

<220>
<221>  misc_feature
<222>  (78)..(79)
<223>  n is unlocked nucleomonomer UNA-C

<220>
<221>  misc_feature
<222>  (80)..(81)
<223>  n is unlocked nucleomonomer UNA-A

<220>
<221>  misc_feature
<222>  (82)..(82)
<223>  n is unlocked nucleomonomer UNA-C

<220>
<221>  misc_feature
<222>  (83)..(84)
<223>  n is unlocked nucleomonomer UNA-U

<220>
<221>  misc_feature
<222>  (85)..(85)
<223>  n is unlocked nucleomonomer UNA-A

<220>
<221>  misc_feature
<222>  (86)..(86)
<223>  n is unlocked nucleomonomer UNA-C

<220>
<221>  misc_feature
<222>  (87)..(87)
<223>  n is unlocked nucleomonomer UNA-A

<220>
<221>  misc_feature
<222>  (88)..(88)
<223>  n is unlocked nucleomonomer UNA-C

<220>
<221>  misc_feature
<222>  (89)..(90)
<223>  n is unlocked nucleomonomer UNA-U

<220>
<221>  misc_feature
<222>  (91)..(91)
<223>  n is unlocked nucleomonomer UNA-A

<220>
<221>  misc_feature
<222>  (92)..(92)
<223>  n is unlocked nucleomonomer UNA-C

<220>
<221>  misc_feature
<222>  (93)..(96)
<223>  n is unlocked nucleomonomer UNA-A

<220>
<221>  misc_feature
<222>  (97)..(97)
<223>  n is unlocked nucleomonomer UNA-U

<220>
<221>  misc_feature
<222>  (98)..(98)
<223>  n is unlocked nucleomonomer UNA-G

<220>
<221>  misc_feature
<222>  (99)..(100)
<223>  n is unlocked nucleomonomer UNA-U

<220>
<221>  misc_feature
<222>  (101)..(101)
<223>  n is unlocked nucleomonomer UNA-G

<220>
<221>  misc_feature
<222>  (102)..(102)
<223>  n is unlocked nucleomonomer UNA-U

<220>
<221>  misc_feature
<222>  (103)..(107)
<223>  n is unlocked nucleomonomer UNA-C

<220>
<221>  misc_feature
<222>  (108)..(111)
<223>  n is unlocked nucleomonomer UNA-A

<220>
<221>  misc_feature
<222>  (112)..(112)
<223>  n is unlocked nucleomonomer UNA-U

<220>
<221>  misc_feature
<222>  (113)..(113)
<223>  n is unlocked nucleomonomer UNA-G

<220>
<221>  misc_feature
<222>  (114)..(114)
<223>  n is unlocked nucleomonomer UNA-U

<220>
<221>  misc_feature
<222>  (115)..(115)
<223>  n is unlocked nucleomonomer UNA-A

<220>
<221>  misc_feature
<222>  (116)..(116)
<223>  n is unlocked nucleomonomer UNA-G

<220>
<221>  misc_feature
<222>  (117)..(118)
<223>  n is unlocked nucleomonomer UNA-C

<220>
<221>  misc_feature
<222>  (119)..(119)
<223>  n is unlocked nucleomonomer UNA-A

<220>
<221>  misc_feature
<222>  (120)..(121)
<223>  n is unlocked nucleomonomer UNA-U

<220>
<221>  misc_feature
<222>  (122)..(122)
<223>  n is unlocked nucleomonomer UNA-C

<220>
<221>  misc_feature
<222>  (123)..(123)
<223>  n is unlocked nucleomonomer UNA-G

<220>
<221>  misc_feature
<222>  (124)..(124)
<223>  n is unlocked nucleomonomer UNA-U

<220>
<221>  misc_feature
<222>  (125)..(125)
<223>  n is unlocked nucleomonomer UNA-A

<220>
<221>  misc_feature
<222>  (126)..(126)
<223>  n is unlocked nucleomonomer UNA-U

<220>
<221>  misc_feature
<222>  (127)..(127)
<223>  n is unlocked nucleomonomer UNA-C

<220>
<221>  misc_feature
<222>  (128)..(128)
<223>  n is unlocked nucleomonomer UNA-U

<220>
<221>  misc_feature
<222>  (129)..(129)
<223>  n is unlocked nucleomonomer UNA-G

<220>
<221>  misc_feature
<222>  (130)..(130)
<223>  n is unlocked nucleomonomer UNA-C

<220>
<221>  misc_feature
<222>  (131)..(131)
<223>  n is unlocked nucleomonomer UNA-U

<220>
<221>  misc_feature
<222>  (132)..(133)
<223>  n is unlocked nucleomonomer UNA-C

<220>
<221>  misc_feature
<222>  (134)..(134)
<223>  n is unlocked nucleomonomer UNA-U

<220>
<221>  misc_feature
<222>  (135)..(136)
<223>  n is unlocked nucleomonomer UNA-A

<220>
<221>  misc_feature
<222>  (137)..(137)
<223>  n is unlocked nucleomonomer UNA-U

<220>
<221>  misc_feature
<222>  (138)..(142)
<223>  n is unlocked nucleomonomer UNA-A

<220>
<221>  misc_feature
<222>  (143)..(143)
<223>  n is unlocked nucleomonomer UNA-G

<220>
<221>  misc_feature
<222>  (144)..(146)
<223>  n is unlocked nucleomonomer UNA-A

<220>
<221>  misc_feature
<222>  (147)..(147)
<223>  n is unlocked nucleomonomer UNA-G

<220>
<221>  misc_feature
<222>  (148)..(149)
<223>  n is unlocked nucleomonomer UNA-U

<220>
<221>  misc_feature
<222>  (150)..(150)
<223>  n is unlocked nucleomonomer UNA-U

<220>
<221>  misc_feature
<222>  (151)..(151)
<223>  n is unlocked nucleomonomer UNA-C

<220>
<221>  misc_feature
<222>  (152)..(153)
<223>  n is unlocked nucleomonomer UNA-U

<220>
<221>  misc_feature
<222>  (154)..(154)
<223>  n is unlocked nucleomonomer UNA-C

<220>
<221>  misc_feature
<222>  (155)..(155)
<223>  n is unlocked nucleomonomer UNA-A

<220>
<221>  misc_feature
<222>  (156)..(156)
<223>  n is unlocked nucleomonomer UNA-C

<220>
<221>  misc_feature
<222>  (157)..(157)
<223>  n is unlocked nucleomonomer UNA-A

<220>
<221>  misc_feature
<222>  (158)..(158)
<223>  n is unlocked nucleomonomer UNA-U

<400>  42
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn       60

nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn      120

nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnn                              158


<210>  43
<211>  114
<212>  RNA
<213>  Unknown

<220>
<223>  Poly(A) 114 Tail

<400>  43
aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa       60

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaa            114


<210>  44
<211>  9
<212>  RNA
<213>  Unknown

<220>
<223>  Triple Stop Codon

<400>  44
auaagugaa                                                                9


<210>  45
<211>  1359
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Codon-Optimized PAH Coding Sequence

<400>  45
augagcaccg ccgugcugga gaaccccggc cugggccgga agcugagcga cuucggccag       60

gagaccagcu acaucgagga caacugcaac cagaacggcg ccaucagccu gaucuucagc      120

cugaaggagg aggugggcgc ccuggccaag gugcugcggc uguucgagga gaacgacgug      180

aaccugaccc acaucgagag ccggcccagc cggcugaaga aggacgagua cgaguucuuc      240

acccaccugg acaagcggag ccugcccgcc cugaccaaca ucaucaagau ccugcggcac      300

gacaucggcg ccaccgugca cgagcugagc cgggacaaga agaaggacac cgugcccugg      360

uucccccgga ccauccagga gcuggaccgg uucgccaacc agauccugag cuacggcgcc      420

gagcuggacg ccgaccaccc cggcuucaag gaccccgugu accgggcccg gcggaagcag      480

uucgccgaca ucgccuacaa cuaccggcac ggccagccca ucccccgggu ggaguacaug      540

gaggaggaga agaagaccug gggcaccgug uucaagaccc ugaagagccu guacaagacc      600

cacgccugcu acgaguacaa ccacaucuuc ccccugcugg agaaguacug cggcuuccac      660

gaggacaaca ucccccagcu ggaggacgug agccaguucc ugcagaccug caccggcuuc      720

cggcugcggc ccguggccgg ccugcugagc agccgggacu uccugggcgg ccuggccuuc      780

cggguguucc acugcaccca guacauccgg cacggcagca agcccaugua cacccccgag      840

cccgacaucu gccacgagcu gcugggccac gugccccugu ucagcgaccg gagcuucgcc      900

caguucagcc aggagaucgg ccuggccagc cugggcgccc ccgacgagua caucgagaag      960

cuggccacca ucuacugguu caccguggag uucggccugu gcaagcaggg cgacagcauc     1020

aaggccuacg gcgccggccu gcugagcagc uucggcgagc ugcaguacug ccugagcgag     1080

aagcccaagc ugcugccccu ggagcuggag aagaccgcca uccagaacua caccgugacc     1140

gaguuccagc cccuguacua cguggccgag agcuucaacg acgccaagga gaaggugcgg     1200

aacuucgccg ccaccauccc ccggcccuuc agcgugcggu acgaccccua cacccagcgg     1260

aucgaggugc uggacaacac ccagcagcug aagauccugg ccgacagcau caacagcgag     1320

aucggcaucc ugugcagcgc ccugcagaag aucaaguaa                            1359


<210>  46
<211>  1359
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Codon-Optimized PAH Coding Sequence

<400>  46
auguccaccg ccguccugga gaaccccggc cucggcagaa aacucucuga cuucggccag       60

gagacaagcu auaucgagga caacugcaau cagaaugggg ccauuucccu gauuuuuucc      120

cucaaagagg aggugggggc ucucgccaaa guccuccggc ucuucgaaga aaaugauguc      180

aaccugaccc auaucgaguc uaggccuucu cgccucaaga aagaugaaua ugaguucuuu      240

acccaccucg auaaacgcag ccugccugcu cugacaaaca uuauuaagau ucucagacac      300

gacaucgggg ccaccgucca cgaacugucc cgggauaaga agaaagacac agugcccugg      360

uuucccagga ccauccagga acuggacagg uucgccaauc agauccucag cuauggcgcc      420

gagcuggaug cugaccaucc uggguucaaa gauccugugu accgcgcuag gcgcaagcag      480

uucgcugaca ucgccuacaa cuaccggcac gggcagccca uuccucgggu ggaguacaug      540

gaagaggaga agaaaacaug gggcacagug uuuaagaccc ugaagucccu cuauaaaacc      600

cacgcuugcu augaauacaa ucauaucuuc ccccugcugg agaaguacug cggcuuucac      660

gaggauaaca ucccccagcu ggaggacgug ucucaguuuc ugcagaccug caccggguuu      720

cggcuccggc cuguggcugg ccugcugucc ucucgcgauu uucucggggg ccuggccuuu      780

cgggucuuuc auugcacaca guacauuagg cacggcucca agcccaugua uacccccgag      840

ccugacauuu gccacgaacu gcucggccac gugccccucu ucuccgaucg gagcuucgcc      900

caguucuccc aggagaucgg ccuggccucu cugggggcuc cugaugagua caucgagaag      960

cucgccacaa ucuacugguu caccguggaa uucgggcucu gcaaacaggg cgacuccauu     1020

aaggcuuaug gggcugggcu ccuguccucc uucggggagc uccaguacug ccucuccgaa     1080

aagcccaagc ugcucccccu ggaacuggaa aagacagcca uucagaauua caccgucaca     1140

gaauuucagc cccucuauua cguggcugaa aguuucaaug augccaagga aaaagucaga     1200

aacuucgcug ccacaauucc ucgccccuuu uccgugcggu acgaccccua cacccagaga     1260

aucgaagucc ucgacaauac ccagcagcug aagauccucg cugauuccau caacagugag     1320

aucggcauuc ugugcagugc ccuccagaaa auuaaguag                            1359


