                               SEQUENCE LISTING

<110> QUENTIS THERAPEUTICS, INC.
 
<120> IRE1 SMALL MOLECULE INHIBITORS

<130> 51089-710.601

<140>
<141>

<150> 62/513,956
<151> 2017-06-01

<160> 7     

<170> PatentIn version 3.5

<210> 1
<211> 977
<212> PRT
<213> Homo sapiens

<400> 1
Met Pro Ala Arg Arg Leu Leu Leu Leu Leu Thr Leu Leu Leu Pro Gly 
1               5                   10                  15      


Leu Gly Ile Phe Gly Ser Thr Ser Thr Val Thr Leu Pro Glu Thr Leu 
            20                  25                  30          


Leu Phe Val Ser Thr Leu Asp Gly Ser Leu His Ala Val Ser Lys Arg 
        35                  40                  45              


Thr Gly Ser Ile Lys Trp Thr Leu Lys Glu Asp Pro Val Leu Gln Val 
    50                  55                  60                  


Pro Thr His Val Glu Glu Pro Ala Phe Leu Pro Asp Pro Asn Asp Gly 
65                  70                  75                  80  


Ser Leu Tyr Thr Leu Gly Ser Lys Asn Asn Glu Gly Leu Thr Lys Leu 
                85                  90                  95      


Pro Phe Thr Ile Pro Glu Leu Val Gln Ala Ser Pro Cys Arg Ser Ser 
            100                 105                 110         


Asp Gly Ile Leu Tyr Met Gly Lys Lys Gln Asp Ile Trp Tyr Val Ile 
        115                 120                 125             


Asp Leu Leu Thr Gly Glu Lys Gln Gln Thr Leu Ser Ser Ala Phe Ala 
    130                 135                 140                 


Asp Ser Leu Cys Pro Ser Thr Ser Leu Leu Tyr Leu Gly Arg Thr Glu 
145                 150                 155                 160 


Tyr Thr Ile Thr Met Tyr Asp Thr Lys Thr Arg Glu Leu Arg Trp Asn 
                165                 170                 175     


Ala Thr Tyr Phe Asp Tyr Ala Ala Ser Leu Pro Glu Asp Asp Val Asp 
            180                 185                 190         


Tyr Lys Met Ser His Phe Val Ser Asn Gly Asp Gly Leu Val Val Thr 
        195                 200                 205             


Val Asp Ser Glu Ser Gly Asp Val Leu Trp Ile Gln Asn Tyr Ala Ser 
    210                 215                 220                 


Pro Val Val Ala Phe Tyr Val Trp Gln Arg Glu Gly Leu Arg Lys Val 
225                 230                 235                 240 


Met His Ile Asn Val Ala Val Glu Thr Leu Arg Tyr Leu Thr Phe Met 
                245                 250                 255     


Ser Gly Glu Val Gly Arg Ile Thr Lys Trp Lys Tyr Pro Phe Pro Lys 
            260                 265                 270         


Glu Thr Glu Ala Lys Ser Lys Leu Thr Pro Thr Leu Tyr Val Gly Lys 
        275                 280                 285             


Tyr Ser Thr Ser Leu Tyr Ala Ser Pro Ser Met Val His Glu Gly Val 
    290                 295                 300                 


Ala Val Val Pro Arg Gly Ser Thr Leu Pro Leu Leu Glu Gly Pro Gln 
305                 310                 315                 320 


Thr Asp Gly Val Thr Ile Gly Asp Lys Gly Glu Cys Val Ile Thr Pro 
                325                 330                 335     


Ser Thr Asp Val Lys Phe Asp Pro Gly Leu Lys Ser Lys Asn Lys Leu 
            340                 345                 350         


Asn Tyr Leu Arg Asn Tyr Trp Leu Leu Ile Gly His His Glu Thr Pro 
        355                 360                 365             


Leu Ser Ala Ser Thr Lys Met Leu Glu Arg Phe Pro Asn Asn Leu Pro 
    370                 375                 380                 


Lys His Arg Glu Asn Val Ile Pro Ala Asp Ser Glu Lys Lys Ser Phe 
385                 390                 395                 400 


Glu Glu Val Ile Asn Leu Val Asp Gln Thr Ser Glu Asn Ala Pro Thr 
                405                 410                 415     


Thr Val Ser Arg Asp Val Glu Glu Lys Pro Ala His Ala Pro Ala Arg 
            420                 425                 430         


Pro Glu Ala Pro Val Asp Ser Met Leu Lys Asp Met Ala Thr Ile Ile 
        435                 440                 445             


Leu Ser Thr Phe Leu Leu Ile Gly Trp Val Ala Phe Ile Ile Thr Tyr 
    450                 455                 460                 


Pro Leu Ser Met His Gln Gln Gln Gln Leu Gln His Gln Gln Phe Gln 
465                 470                 475                 480 


Lys Glu Leu Glu Lys Ile Gln Leu Leu Gln Gln Gln Gln Gln Gln Leu 
                485                 490                 495     


Pro Phe His Pro Pro Gly Asp Thr Ala Gln Asp Gly Glu Leu Leu Asp 
            500                 505                 510         


Thr Ser Gly Pro Tyr Ser Glu Ser Ser Gly Thr Ser Ser Pro Ser Thr 
        515                 520                 525             


Ser Pro Arg Ala Ser Asn His Ser Leu Cys Ser Gly Ser Ser Ala Ser 
    530                 535                 540                 


Lys Ala Gly Ser Ser Pro Ser Leu Glu Gln Asp Asp Gly Asp Glu Glu 
545                 550                 555                 560 


Thr Ser Val Val Ile Val Gly Lys Ile Ser Phe Cys Pro Lys Asp Val 
                565                 570                 575     


Leu Gly His Gly Ala Glu Gly Thr Ile Val Tyr Arg Gly Met Phe Asp 
            580                 585                 590         


Asn Arg Asp Val Ala Val Lys Arg Ile Leu Pro Glu Cys Phe Ser Phe 
        595                 600                 605             


Ala Asp Arg Glu Val Gln Leu Leu Arg Glu Ser Asp Glu His Pro Asn 
    610                 615                 620                 


Val Ile Arg Tyr Phe Cys Thr Glu Lys Asp Arg Gln Phe Gln Tyr Ile 
625                 630                 635                 640 


Ala Ile Glu Leu Cys Ala Ala Thr Leu Gln Glu Tyr Val Glu Gln Lys 
                645                 650                 655     


Asp Phe Ala His Leu Gly Leu Glu Pro Ile Thr Leu Leu Gln Gln Thr 
            660                 665                 670         


Thr Ser Gly Leu Ala His Leu His Ser Leu Asn Ile Val His Arg Asp 
        675                 680                 685             


Leu Lys Pro His Asn Ile Leu Ile Ser Met Pro Asn Ala His Gly Lys 
    690                 695                 700                 


Ile Lys Ala Met Ile Ser Asp Phe Gly Leu Cys Lys Lys Leu Ala Val 
705                 710                 715                 720 


Gly Arg His Ser Phe Ser Arg Arg Ser Gly Val Pro Gly Thr Glu Gly 
                725                 730                 735     


Trp Ile Ala Pro Glu Met Leu Ser Glu Asp Cys Lys Glu Asn Pro Thr 
            740                 745                 750         


Tyr Thr Val Asp Ile Phe Ser Ala Gly Cys Val Phe Tyr Tyr Val Ile 
        755                 760                 765             


Ser Glu Gly Ser His Pro Phe Gly Lys Ser Leu Gln Arg Gln Ala Asn 
    770                 775                 780                 


Ile Leu Leu Gly Ala Cys Ser Leu Asp Cys Leu His Pro Glu Lys His 
785                 790                 795                 800 


Glu Asp Val Ile Ala Arg Glu Leu Ile Glu Lys Met Ile Ala Met Asp 
                805                 810                 815     


Pro Gln Lys Arg Pro Ser Ala Lys His Val Leu Lys His Pro Phe Phe 
            820                 825                 830         


Trp Ser Leu Glu Lys Gln Leu Gln Phe Phe Gln Asp Val Ser Asp Arg 
        835                 840                 845             


Ile Glu Lys Glu Ser Leu Asp Gly Pro Ile Val Lys Gln Leu Glu Arg 
    850                 855                 860                 


Gly Gly Arg Ala Val Val Lys Met Asp Trp Arg Glu Asn Ile Thr Val 
865                 870                 875                 880 


Pro Leu Gln Thr Asp Leu Arg Lys Phe Arg Thr Tyr Lys Gly Gly Ser 
                885                 890                 895     


Val Arg Asp Leu Leu Arg Ala Met Arg Asn Lys Lys His His Tyr Arg 
            900                 905                 910         


Glu Leu Pro Ala Glu Val Arg Glu Thr Leu Gly Ser Leu Pro Asp Asp 
        915                 920                 925             


Phe Val Cys Tyr Phe Thr Ser Arg Phe Pro His Leu Leu Ala His Thr 
    930                 935                 940                 


Tyr Arg Ala Met Glu Leu Cys Ser His Glu Arg Leu Phe Gln Pro Tyr 
945                 950                 955                 960 


Tyr Phe His Glu Pro Pro Glu Pro Gln Pro Pro Val Thr Pro Asp Ala 
                965                 970                 975     


Leu 
    


<210> 2
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      probe

<400> 2
cauguccgca gcacaug                                                      17


<210> 3
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      probe

<400> 3
caugucccca gcacaug                                                      17


<210> 4
<211> 434
<212> PRT
<213> Saccharomyces cerevisiae

<400> 4
Ser Arg Ile Ala Asn Ile Pro Asn Phe Glu Gln Ser Leu Lys Asn Leu 
1               5                   10                  15      


Val Val Ser Glu Lys Ile Leu Gly Tyr Gly Ser Ser Gly Thr Val Val 
            20                  25                  30          


Phe Gln Gly Ser Phe Gln Gly Arg Pro Val Ala Val Lys Arg Met Leu 
        35                  40                  45              


Ile Asp Phe Cys Asp Ile Ala Leu Met Glu Ile Lys Leu Leu Thr Glu 
    50                  55                  60                  


Ser Asp Asp His Pro Asn Val Ile Arg Tyr Tyr Cys Ser Glu Thr Thr 
65                  70                  75                  80  


Asp Arg Phe Leu Tyr Ile Ala Leu Glu Leu Cys Asn Leu Asn Leu Gln 
                85                  90                  95      


Asp Leu Val Glu Ser Lys Asn Val Ser Asp Glu Asn Leu Lys Leu Gln 
            100                 105                 110         


Lys Glu Tyr Asn Pro Ile Ser Leu Leu Arg Gln Ile Ala Ser Gly Val 
        115                 120                 125             


Ala His Leu His Ser Leu Lys Ile Ile His Arg Asp Leu Lys Pro Gln 
    130                 135                 140                 


Asn Ile Leu Val Ser Thr Ser Ser Arg Phe Thr Ala Asp Gln Gln Thr 
145                 150                 155                 160 


Gly Ala Glu Asn Leu Arg Ile Leu Ile Ser Asp Phe Gly Leu Cys Lys 
                165                 170                 175     


Lys Leu Asp Ser Gly Gln Ser Ser Phe Arg Thr Asn Leu Asn Asn Pro 
            180                 185                 190         


Ser Gly Thr Ser Gly Trp Arg Ala Pro Glu Leu Leu Glu Glu Ser Asn 
        195                 200                 205             


Asn Leu Gln Thr Lys Arg Arg Leu Thr Arg Ser Ile Asp Ile Phe Ser 
    210                 215                 220                 


Met Gly Cys Val Phe Tyr Tyr Ile Leu Ser Lys Gly Lys His Pro Phe 
225                 230                 235                 240 


Gly Asp Lys Tyr Ser Arg Glu Ser Asn Ile Ile Arg Gly Ile Phe Ser 
                245                 250                 255     


Leu Asp Glu Met Lys Cys Leu His Asp Arg Ser Leu Ile Ala Glu Ala 
            260                 265                 270         


Thr Asp Leu Ile Ser Gln Met Ile Asp His Asp Pro Leu Lys Arg Pro 
        275                 280                 285             


Thr Ala Met Lys Val Leu Arg His Pro Leu Phe Trp Pro Lys Ser Lys 
    290                 295                 300                 


Lys Leu Glu Phe Leu Leu Lys Val Ser Asp Arg Leu Glu Ile Glu Asn 
305                 310                 315                 320 


Arg Asp Pro Pro Ser Ala Leu Leu Met Lys Phe Asp Ala Gly Ser Asp 
                325                 330                 335     


Phe Val Ile Pro Ser Gly Asp Trp Thr Val Lys Phe Asp Lys Ile Phe 
            340                 345                 350         


Met Asp Asn Leu Glu Arg Tyr Arg Lys Tyr His Ser Ser Lys Leu Met 
        355                 360                 365             


Asp Leu Leu Arg Ala Leu Arg Asn Lys Tyr His His Phe Met Asp Leu 
    370                 375                 380                 


Pro Glu Asp Ile Ala Glu Leu Met Gly Pro Val Pro Asp Gly Phe Tyr 
385                 390                 395                 400 


Asp Tyr Phe Ile Lys Arg Phe Pro Asn Leu Leu Ile Gly Val Tyr Met 
                405                 410                 415     


Ile Val Lys Glu Asn Leu Ser Asp Asp Gln Ile Leu Arg Glu Phe Leu 
            420                 425                 430         


Tyr Ser 
        


<210> 5
<211> 424
<212> PRT
<213> Homo sapiens

<400> 5
Asp Asp Gly Asp Glu Glu Thr Ser Val Val Ile Val Gly Lys Ile Ser 
1               5                   10                  15      


Phe Cys Pro Lys Asp Val Leu Gly His Gly Ala Glu Gly Thr Ile Val 
            20                  25                  30          


Tyr Arg Gly Met Phe Asp Asn Arg Asp Val Ala Val Lys Arg Ile Leu 
        35                  40                  45              


Pro Glu Cys Phe Ser Phe Ala Asp Arg Glu Val Gln Leu Leu Arg Glu 
    50                  55                  60                  


Ser Asp Glu His Pro Asn Val Ile Arg Tyr Phe Cys Thr Glu Lys Asp 
65                  70                  75                  80  


Arg Gln Phe Gln Tyr Ile Ala Ile Glu Leu Cys Ala Ala Thr Leu Gln 
                85                  90                  95      


Glu Tyr Val Glu Gln Lys Asp Cys Phe Ala His Leu Gly Leu Glu Pro 
            100                 105                 110         


Ile Thr Leu Leu Gln Gln Thr Thr Ser Gly Leu Ala His Leu His Ser 
        115                 120                 125             


Leu Asn Ile Val His Arg Asp Leu Lys Pro His Asn Ile Leu Ile Ser 
    130                 135                 140                 


Met Pro Asn Ala His Gly Lys Ile Lys Ala Met Ile Ser Asp Phe Gly 
145                 150                 155                 160 


Leu Cys Lys Lys Leu Ala Val Gly Arg His Ser Phe Ser Arg Arg Ser 
                165                 170                 175     


Gly Val Pro Gly Thr Glu Gly Trp Ile Ala Pro Glu Met Leu Ser Glu 
            180                 185                 190         


Asp Cys Lys Glu Asn Pro Thr Tyr Thr Val Asp Ile Phe Ser Ala Gly 
        195                 200                 205             


Cys Val Phe Tyr Tyr Val Val Ser Glu Gly Ser His Pro Phe Gly Lys 
    210                 215                 220                 


Ser Leu Gln Arg Gln Ala Asn Ile Leu Leu Gly Ala Cys Ser Leu Asp 
225                 230                 235                 240 


Cys Leu His Pro Glu Lys His Glu Asp Val Ile Ala Arg Glu Leu Ile 
                245                 250                 255     


Glu Lys Met Ile Ala Met Asp Pro Gln Lys Arg Pro Ser Ala Asn Asp 
            260                 265                 270         


Val Leu Lys His Pro Phe Phe Trp Ser Leu Glu Lys Gln Leu Gln Phe 
        275                 280                 285             


Phe Gln Asp Val Ser Asp Arg Ile Glu Lys Glu Ser Leu Asp Gly Pro 
    290                 295                 300                 


Ile Val Lys Gln Leu Glu Arg Gly Gly Arg Ala Val Val Lys Met Asp 
305                 310                 315                 320 


Trp Arg Glu Asn Ile Thr Asp Pro Leu Gln Thr Asp Leu Arg Lys Phe 
                325                 330                 335     


Arg Thr Tyr Lys Gly Gly Ser Val Arg Asp Leu Leu Arg Ala Met Arg 
            340                 345                 350         


Asn Lys Lys His His Tyr Arg Asp Leu Pro Glu Glu Val Arg Glu Thr 
        355                 360                 365             


Leu Gly Thr Leu Pro Asp Asp Phe Val Cys Tyr Phe Thr Ser Arg Phe 
    370                 375                 380                 


Pro His Leu Leu Ala His Thr Tyr Arg Ala Met Glu Leu Cys Ser His 
385                 390                 395                 400 


Glu Arg Leu Phe Gln Pro Tyr Tyr Phe His Glu Pro Pro Glu Pro Gln 
                405                 410                 415     


Pro Pro Val Thr Pro Asp Ala Leu 
            420                 


<210> 6
<211> 423
<212> PRT
<213> Mus musculus

<400> 6
Asp Asp Glu Asp Glu Glu Thr Arg Met Val Ile Val Gly Lys Ile Ser 
1               5                   10                  15      


Phe Cys Pro Lys Asp Val Leu Gly His Gly Ala Glu Gly Thr Ile Val 
            20                  25                  30          


Tyr Lys Gly Met Phe Asp Asn Arg Asp Val Ala Val Lys Arg Ile Leu 
        35                  40                  45              


Pro Glu Cys Phe Ser Phe Ala Asp Arg Glu Val Gln Leu Leu Arg Glu 
    50                  55                  60                  


Ser Asp Glu His Pro Asn Val Ile Arg Tyr Phe Cys Thr Glu Lys Asp 
65                  70                  75                  80  


Arg Gln Phe Gln Tyr Ile Ala Ile Glu Leu Cys Ala Ala Thr Leu Gln 
                85                  90                  95      


Glu Tyr Val Glu Gln Lys Asp Phe Ala His Leu Gly Leu Glu Pro Ile 
            100                 105                 110         


Thr Leu Leu His Gln Thr Thr Ser Gly Leu Ala His Leu His Ser Leu 
        115                 120                 125             


Asn Ile Val His Arg Asp Leu Lys Pro His Asn Ile Leu Leu Ser Met 
    130                 135                 140                 


Pro Asn Ala His Gly Arg Ile Lys Ala Met Ile Ser Asp Phe Gly Leu 
145                 150                 155                 160 


Cys Lys Lys Leu Ala Val Gly Arg His Ser Phe Ser Arg Arg Ser Gly 
                165                 170                 175     


Val Pro Gly Thr Glu Gly Trp Ile Ala Pro Glu Met Leu Ser Glu Asp 
            180                 185                 190         


Cys Lys Asp Asn Pro Thr Tyr Thr Val Asp Ile Phe Ser Ala Gly Cys 
        195                 200                 205             


Val Phe Tyr Tyr Val Ile Ser Glu Gly Asn His Pro Phe Gly Lys Ser 
    210                 215                 220                 


Leu Gln Arg Gln Ala Asn Ile Leu Leu Gly Ala Cys Asn Leu Asp Cys 
225                 230                 235                 240 


Phe His Ser Asp Lys His Glu Asp Val Ile Ala Arg Glu Leu Ile Glu 
                245                 250                 255     


Lys Met Ile Ala Met Asp Pro Gln Gln Arg Pro Ser Ala Lys His Val 
            260                 265                 270         


Leu Lys His Pro Phe Phe Trp Ser Leu Glu Lys Gln Leu Gln Phe Phe 
        275                 280                 285             


Gln Asp Val Ser Asp Arg Ile Glu Lys Glu Ala Leu Asp Gly Pro Ile 
    290                 295                 300                 


Val Arg Gln Leu Glu Arg Gly Gly Arg Ala Val Val Lys Met Asp Trp 
305                 310                 315                 320 


Arg Glu Asn Ile Thr Val Pro Leu Gln Thr Asp Leu Arg Lys Phe Arg 
                325                 330                 335     


Thr Tyr Lys Gly Gly Ser Val Arg Asp Leu Leu Arg Ala Met Arg Asn 
            340                 345                 350         


Lys Lys His His Tyr Arg Glu Leu Pro Ala Glu Val Gln Glu Thr Leu 
        355                 360                 365             


Gly Ser Ile Pro Asp Asp Phe Val Arg Tyr Phe Thr Ser Arg Phe Pro 
    370                 375                 380                 


His Leu Leu Ser His Thr Tyr Gln Ala Met Glu Leu Cys Arg His Glu 
385                 390                 395                 400 


Arg Leu Phe Gln Thr Tyr Tyr Trp His Glu Pro Thr Glu Pro Gln Pro 
                405                 410                 415     


Pro Val Ile Pro Tyr Ala Leu 
            420             


<210> 7
<211> 423
<212> PRT
<213> Rattus norvegicus

<400> 7
Asp Asp Glu Asp Glu Glu Thr Arg Met Val Ile Val Gly Lys Ile Ser 
1               5                   10                  15      


Phe Cys Pro Lys Asp Val Leu Gly His Gly Ala Glu Gly Thr Ile Val 
            20                  25                  30          


Tyr Lys Gly Met Phe Asp Asn Arg Asp Val Ala Val Lys Arg Ile Leu 
        35                  40                  45              


Pro Glu Cys Phe Ser Phe Ala Asp Arg Glu Val Gln Leu Leu Arg Glu 
    50                  55                  60                  


Ser Asp Glu His Pro Asn Val Ile Arg Tyr Phe Cys Thr Glu Lys Asp 
65                  70                  75                  80  


Arg Gln Phe Gln Tyr Ile Ala Ile Glu Leu Cys Ala Ala Thr Leu Gln 
                85                  90                  95      


Glu Tyr Val Glu Gln Lys Asp Phe Ala His Leu Gly Leu Glu Pro Ile 
            100                 105                 110         


Thr Leu Leu His Gln Thr Thr Ser Gly Leu Ala His Leu His Ser Leu 
        115                 120                 125             


Asn Ile Val His Arg Asp Leu Lys Pro His Asn Ile Leu Leu Ser Met 
    130                 135                 140                 


Pro Asn Ala His Gly Arg Ile Lys Ala Met Ile Ser Asp Phe Gly Leu 
145                 150                 155                 160 


Cys Lys Lys Leu Ala Val Gly Arg His Ser Phe Ser Arg Arg Ser Gly 
                165                 170                 175     


Val Pro Gly Thr Glu Gly Trp Ile Ala Pro Glu Met Leu Ser Glu Asp 
            180                 185                 190         


Cys Lys Glu Asn Pro Thr Tyr Thr Val Asp Ile Phe Ser Ala Gly Cys 
        195                 200                 205             


Val Phe Tyr Tyr Val Ile Ser Glu Gly Asn His Pro Phe Gly Lys Ser 
    210                 215                 220                 


Leu Gln Arg Gln Ala Asn Ile Leu Leu Gly Ala Cys Ser Leu Asp Cys 
225                 230                 235                 240 


Phe His Ser Asp Lys His Glu Asp Val Ile Ala Arg Glu Leu Ile Glu 
                245                 250                 255     


Lys Met Ile Ala Met Asp Pro Gln Gln Arg Pro Ser Ala Lys His Val 
            260                 265                 270         


Leu Lys His Pro Phe Phe Trp Ser Leu Glu Lys Gln Leu Gln Phe Phe 
        275                 280                 285             


Gln Asp Val Ser Asp Arg Ile Glu Lys Glu Ser Leu Asp Gly Pro Ile 
    290                 295                 300                 


Val Arg Gln Leu Glu Arg Gly Gly Arg Ala Val Val Lys Met Asp Trp 
305                 310                 315                 320 


Arg Glu Asn Ile Thr Val Pro Leu Gln Thr Asp Leu Arg Lys Phe Arg 
                325                 330                 335     


Thr Tyr Lys Gly Gly Ser Val Arg Asp Leu Leu Arg Ala Met Arg Asn 
            340                 345                 350         


Lys Arg His His Tyr Arg Glu Leu Pro Leu Glu Val Gln Glu Thr Leu 
        355                 360                 365             


Gly Ser Ile Pro Asp Asp Phe Val Arg Tyr Phe Thr Ser Arg Phe Pro 
    370                 375                 380                 


His Leu Leu Ser His Thr Tyr Arg Ala Met Glu Leu Cys Arg His Glu 
385                 390                 395                 400 


Arg Leu Phe Gln Thr Tyr Tyr Trp His Glu Pro Thr Glu Ala Gln Pro 
                405                 410                 415     


Pro Gly Ile Pro Asp Ala Leu 
            420             


