                               SEQUENCE LISTING

<110> TRUSTEES OF BOSTON UNIVERSITY
 
<120> MECHANO-ACTIVATED CONTROL OF GENE EXPRESSION

<130> 701586-089500WOPT

<140> PCT/US2018/035407
<141> 2018-05-31

<150> 62/586,451
<151> 2017-11-15

<150> 62/513,031
<151> 2017-05-31

<160> 70    

<170> PatentIn version 3.5

<210> 1
<211> 51
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      signal sequence

<400> 1
Ala Val Gly Gln Asp Thr Gln Glu Val Ile Val Val Pro His Ser Leu 
1               5                   10                  15      


Pro Phe Lys Val Val Val Ile Ser Ala Ile Leu Ala Leu Val Val Leu 
            20                  25                  30          


Thr Ile Ile Ser Leu Ile Ile Leu Ile Met Leu Trp Gln Lys Lys Pro 
        35                  40                  45              


Arg Arg Thr 
    50      


<210> 2
<211> 1408
<212> PRT
<213> Homo sapiens

<400> 2
Arg Gly Pro Arg Cys Ser Gln Pro Gly Glu Thr Cys Leu Asn Gly Gly 
1               5                   10                  15      


Lys Cys Glu Ala Ala Asn Gly Thr Glu Ala Cys Val Cys Gly Gly Ala 
            20                  25                  30          


Phe Val Gly Pro Arg Cys Gln Asp Pro Asn Pro Cys Leu Ser Thr Pro 
        35                  40                  45              


Cys Lys Asn Ala Gly Thr Cys His Val Val Asp Arg Arg Gly Val Ala 
    50                  55                  60                  


Asp Tyr Ala Cys Ser Cys Ala Leu Gly Phe Ser Gly Pro Leu Cys Leu 
65                  70                  75                  80  


Thr Pro Leu Asp Asn Ala Cys Leu Thr Asn Pro Cys Arg Asn Gly Gly 
                85                  90                  95      


Thr Cys Asp Leu Leu Thr Leu Thr Glu Tyr Lys Cys Arg Cys Pro Pro 
            100                 105                 110         


Gly Trp Ser Gly Lys Ser Cys Gln Gln Ala Asp Pro Cys Ala Ser Asn 
        115                 120                 125             


Pro Cys Ala Asn Gly Gly Gln Cys Leu Pro Phe Glu Ala Ser Tyr Ile 
    130                 135                 140                 


Cys His Cys Pro Pro Ser Phe His Gly Pro Thr Cys Arg Gln Asp Val 
145                 150                 155                 160 


Asn Glu Cys Gly Gln Lys Pro Gly Leu Cys Arg His Gly Gly Thr Cys 
                165                 170                 175     


His Asn Glu Val Gly Ser Tyr Arg Cys Val Cys Arg Ala Thr His Thr 
            180                 185                 190         


Gly Pro Asn Cys Glu Arg Pro Tyr Val Pro Cys Ser Pro Ser Pro Cys 
        195                 200                 205             


Gln Asn Gly Gly Thr Cys Arg Pro Thr Gly Asp Val Thr His Glu Cys 
    210                 215                 220                 


Ala Cys Leu Pro Gly Phe Thr Gly Gln Asn Cys Glu Glu Asn Ile Asp 
225                 230                 235                 240 


Asp Cys Pro Gly Asn Asn Cys Lys Asn Gly Gly Ala Cys Val Asp Gly 
                245                 250                 255     


Val Asn Thr Tyr Asn Cys Arg Cys Pro Pro Glu Trp Thr Gly Gln Tyr 
            260                 265                 270         


Cys Thr Glu Asp Val Asp Glu Cys Gln Leu Met Pro Asn Ala Cys Gln 
        275                 280                 285             


Asn Gly Gly Thr Cys His Asn Thr His Gly Gly Tyr Asn Cys Val Cys 
    290                 295                 300                 


Val Asn Gly Trp Thr Gly Glu Asp Cys Ser Glu Asn Ile Asp Asp Cys 
305                 310                 315                 320 


Ala Ser Ala Ala Cys Phe His Gly Ala Thr Cys His Asp Arg Val Ala 
                325                 330                 335     


Ser Phe Tyr Cys Glu Cys Pro His Gly Arg Thr Gly Leu Leu Cys His 
            340                 345                 350         


Leu Asn Asp Ala Cys Ile Ser Asn Pro Cys Asn Glu Gly Ser Asn Cys 
        355                 360                 365             


Asp Thr Asn Pro Val Asn Gly Lys Ala Ile Cys Thr Cys Pro Ser Gly 
    370                 375                 380                 


Tyr Thr Gly Pro Ala Cys Ser Gln Asp Val Asp Glu Cys Ser Leu Gly 
385                 390                 395                 400 


Ala Asn Pro Cys Glu His Ala Gly Lys Cys Ile Asn Thr Leu Gly Ser 
                405                 410                 415     


Phe Glu Cys Gln Cys Leu Gln Gly Tyr Thr Gly Pro Arg Cys Glu Ile 
            420                 425                 430         


Asp Val Asn Glu Cys Val Ser Asn Pro Cys Gln Asn Asp Ala Thr Cys 
        435                 440                 445             


Leu Asp Gln Ile Gly Glu Phe Gln Cys Ile Cys Met Pro Gly Tyr Glu 
    450                 455                 460                 


Gly Val His Cys Glu Val Asn Thr Asp Glu Cys Ala Ser Ser Pro Cys 
465                 470                 475                 480 


Leu His Asn Gly Arg Cys Leu Asp Lys Ile Asn Glu Phe Gln Cys Glu 
                485                 490                 495     


Cys Pro Thr Gly Phe Thr Gly His Leu Cys Gln Tyr Asp Val Asp Glu 
            500                 505                 510         


Cys Ala Ser Thr Pro Cys Lys Asn Gly Ala Lys Cys Leu Asp Gly Pro 
        515                 520                 525             


Asn Thr Tyr Thr Cys Val Cys Thr Glu Gly Tyr Thr Gly Thr His Cys 
    530                 535                 540                 


Glu Val Asp Ile Asp Glu Cys Asp Pro Asp Pro Cys His Tyr Gly Ser 
545                 550                 555                 560 


Cys Lys Asp Gly Val Ala Thr Phe Thr Cys Leu Cys Arg Pro Gly Tyr 
                565                 570                 575     


Thr Gly His His Cys Glu Thr Asn Ile Asn Glu Cys Ser Ser Gln Pro 
            580                 585                 590         


Cys Arg His Gly Gly Thr Cys Gln Asp Arg Asp Asn Ala Tyr Leu Cys 
        595                 600                 605             


Phe Cys Leu Lys Gly Thr Thr Gly Pro Asn Cys Glu Ile Asn Leu Asp 
    610                 615                 620                 


Asp Cys Ala Ser Ser Pro Cys Asp Ser Gly Thr Cys Leu Asp Lys Ile 
625                 630                 635                 640 


Asp Gly Tyr Glu Cys Ala Cys Glu Pro Gly Tyr Thr Gly Ser Met Cys 
                645                 650                 655     


Asn Ile Asn Ile Asp Glu Cys Ala Gly Asn Pro Cys His Asn Gly Gly 
            660                 665                 670         


Thr Cys Glu Asp Gly Ile Asn Gly Phe Thr Cys Arg Cys Pro Glu Gly 
        675                 680                 685             


Tyr His Asp Pro Thr Cys Leu Ser Glu Val Asn Glu Cys Asn Ser Asn 
    690                 695                 700                 


Pro Cys Val His Gly Ala Cys Arg Asp Ser Leu Asn Gly Tyr Lys Cys 
705                 710                 715                 720 


Asp Cys Asp Pro Gly Trp Ser Gly Thr Asn Cys Asp Ile Asn Asn Asn 
                725                 730                 735     


Glu Cys Glu Ser Asn Pro Cys Val Asn Gly Gly Thr Cys Lys Asp Met 
            740                 745                 750         


Thr Ser Gly Tyr Val Cys Thr Cys Arg Glu Gly Phe Ser Gly Pro Asn 
        755                 760                 765             


Cys Gln Thr Asn Ile Asn Glu Cys Ala Ser Asn Pro Cys Leu Asn Gln 
    770                 775                 780                 


Gly Thr Cys Ile Asp Asp Val Ala Gly Tyr Lys Cys Asn Cys Leu Leu 
785                 790                 795                 800 


Pro Tyr Thr Gly Ala Thr Cys Glu Val Val Leu Ala Pro Cys Ala Pro 
                805                 810                 815     


Ser Pro Cys Arg Asn Gly Gly Glu Cys Arg Gln Ser Glu Asp Tyr Glu 
            820                 825                 830         


Ser Phe Ser Cys Val Cys Pro Thr Gly Trp Gln Ala Gly Gln Thr Cys 
        835                 840                 845             


Glu Val Asp Ile Asn Glu Cys Val Leu Ser Pro Cys Arg His Gly Ala 
    850                 855                 860                 


Ser Cys Gln Asn Thr His Gly Gly Tyr Arg Cys His Cys Gln Ala Gly 
865                 870                 875                 880 


Tyr Ser Gly Arg Asn Cys Glu Thr Asp Ile Asp Asp Cys Arg Pro Asn 
                885                 890                 895     


Pro Cys His Asn Gly Gly Ser Cys Thr Asp Gly Ile Asn Thr Ala Phe 
            900                 905                 910         


Cys Asp Cys Leu Pro Gly Phe Arg Gly Thr Phe Cys Glu Glu Asp Ile 
        915                 920                 925             


Asn Glu Cys Ala Ser Asp Pro Cys Arg Asn Gly Ala Asn Cys Thr Asp 
    930                 935                 940                 


Cys Val Asp Ser Tyr Thr Cys Thr Cys Pro Ala Gly Phe Ser Gly Ile 
945                 950                 955                 960 


His Cys Glu Asn Asn Thr Pro Asp Cys Thr Glu Ser Ser Cys Phe Asn 
                965                 970                 975     


Gly Gly Thr Cys Val Asp Gly Ile Asn Ser Phe Thr Cys Leu Cys Pro 
            980                 985                 990         


Pro Gly Phe Thr Gly Ser Tyr Cys  Gln His Asp Val Asn  Glu Cys Asp 
        995                 1000                 1005             


Ser Gln  Pro Cys Leu His Gly  Gly Thr Cys Gln Asp  Gly Cys Gly 
    1010                 1015                 1020             


Ser Tyr  Arg Cys Thr Cys Pro  Gln Gly Tyr Thr Gly  Pro Asn Cys 
    1025                 1030                 1035             


Gln Asn  Leu Val His Trp Cys  Asp Ser Ser Pro Cys  Lys Asn Gly 
    1040                 1045                 1050             


Gly Lys  Cys Trp Gln Thr His  Thr Gln Tyr Arg Cys  Glu Cys Pro 
    1055                 1060                 1065             


Ser Gly  Trp Thr Gly Leu Tyr  Cys Asp Val Pro Ser  Val Ser Cys 
    1070                 1075                 1080             


Glu Val  Ala Ala Gln Arg Gln  Gly Val Asp Val Ala  Arg Leu Cys 
    1085                 1090                 1095             


Gln His  Gly Gly Leu Cys Val  Asp Ala Gly Asn Thr  His His Cys 
    1100                 1105                 1110             


Arg Cys  Gln Ala Gly Tyr Thr  Gly Ser Tyr Cys Glu  Asp Leu Val 
    1115                 1120                 1125             


Asp Glu  Cys Ser Pro Ser Pro  Cys Gln Asn Gly Ala  Thr Cys Thr 
    1130                 1135                 1140             


Asp Tyr  Leu Gly Gly Tyr Ser  Cys Lys Cys Val Ala  Gly Tyr His 
    1145                 1150                 1155             


Gly Val  Asn Cys Ser Glu Glu  Ile Asp Glu Cys Leu  Ser His Pro 
    1160                 1165                 1170             


Cys Gln  Asn Gly Gly Thr Cys  Leu Asp Leu Pro Asn  Thr Tyr Lys 
    1175                 1180                 1185             


Cys Ser  Cys Pro Arg Gly Thr  Gln Gly Val His Cys  Glu Ile Asn 
    1190                 1195                 1200             


Val Asp  Asp Cys Asn Pro Pro  Val Asp Pro Val Ser  Arg Ser Pro 
    1205                 1210                 1215             


Lys Cys  Phe Asn Asn Gly Thr  Cys Val Asp Gln Val  Gly Gly Tyr 
    1220                 1225                 1230             


Ser Cys  Thr Cys Pro Pro Gly  Phe Val Gly Glu Arg  Cys Glu Gly 
    1235                 1240                 1245             


Asp Val  Asn Glu Cys Leu Ser  Asn Pro Cys Asp Ala  Arg Gly Thr 
    1250                 1255                 1260             


Gln Asn  Cys Val Gln Arg Val  Asn Asp Phe His Cys  Glu Cys Arg 
    1265                 1270                 1275             


Ala Gly  His Thr Gly Arg Arg  Cys Glu Ser Val Ile  Asn Gly Cys 
    1280                 1285                 1290             


Lys Gly  Lys Pro Cys Lys Asn  Gly Gly Thr Cys Ala  Val Ala Ser 
    1295                 1300                 1305             


Asn Thr  Ala Arg Gly Phe Ile  Cys Lys Cys Pro Ala  Gly Phe Glu 
    1310                 1315                 1320             


Gly Ala  Thr Cys Glu Asn Asp  Ala Arg Thr Cys Gly  Ser Leu Arg 
    1325                 1330                 1335             


Cys Leu  Asn Gly Gly Thr Cys  Ile Ser Gly Pro Arg  Ser Pro Thr 
    1340                 1345                 1350             


Cys Leu  Cys Leu Gly Pro Phe  Thr Gly Pro Glu Cys  Gln Phe Pro 
    1355                 1360                 1365             


Ala Ser  Ser Pro Cys Leu Gly  Gly Asn Pro Cys Tyr  Asn Gln Gly 
    1370                 1375                 1380             


Thr Cys  Glu Pro Thr Ser Glu  Ser Pro Phe Tyr Arg  Cys Leu Cys 
    1385                 1390                 1395             


Pro Ala  Lys Phe Asn Gly Leu  Leu Cys His 
    1400                 1405             


<210> 3
<211> 128
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 3
Met Ala Asp Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala 
1               5                   10                  15      


Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Ile Ser 
            20                  25                  30          


Met Ala Ala Met Ser Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu 
        35                  40                  45              


Phe Val Ala Gly Ile Ser Arg Ser Ala Gly Ser Ala Val His Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Thr Lys Asn Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Lys Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ala Val Arg Thr Ser Gly Phe Phe Gly Ser Ile Pro Arg Thr 
            100                 105                 110         


Gly Thr Ala Phe Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser 
        115                 120                 125             


<210> 4
<211> 251
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      scFv alphaFITC

<400> 4
Gln Val Gln Leu Val Glu Ser Gly Gly Asn Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Gly Ser Phe 
            20                  25                  30          


Ser Met Ser Trp Val Arg Gln Ala Pro Gly Gly Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Gly Leu Ser Ala Arg Ser Ser Leu Thr His Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Val Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg Ser Tyr Asp Ser Ser Gly Tyr Ala Gly His Phe Tyr Ser 
            100                 105                 110         


Tyr Met Asp Val Trp Gly Gln Gly Thr Leu Val Thr Val Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser Val Leu 
    130                 135                 140                 


Thr Gln Pro Ser Ser Val Ser Ala Ala Pro Gly Gln Lys Val Thr Ile 
145                 150                 155                 160 


Ser Cys Ser Gly Ser Thr Ser Asn Ile Gly Asn Asn Tyr Val Ser Trp 
                165                 170                 175     


Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu Met Ile Tyr Asp Val 
            180                 185                 190         


Ser Lys Arg Pro Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Lys Ser 
        195                 200                 205             


Gly Asn Ser Ala Ser Leu Asp Ile Ser Gly Leu Gln Ser Glu Asp Glu 
    210                 215                 220                 


Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu Ser Glu Phe Leu 
225                 230                 235                 240 


Phe Gly Thr Gly Thr Lys Leu Thr Val Leu Gly 
                245                 250     


<210> 5
<211> 182
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 5
Met Asp Lys Asp Cys Glu Met Lys Arg Thr Thr Leu Asp Ser Pro Leu 
1               5                   10                  15      


Gly Lys Leu Glu Leu Ser Gly Cys Glu Gln Gly Leu His Arg Ile Ile 
            20                  25                  30          


Phe Leu Gly Lys Gly Thr Ser Ala Ala Asp Ala Val Glu Val Pro Ala 
        35                  40                  45              


Pro Ala Ala Val Leu Gly Gly Pro Glu Pro Leu Met Gln Ala Thr Ala 
    50                  55                  60                  


Trp Leu Asn Ala Tyr Phe His Gln Pro Glu Ala Ile Glu Glu Phe Pro 
65                  70                  75                  80  


Val Pro Ala Leu His His Pro Val Phe Gln Gln Glu Ser Phe Thr Arg 
                85                  90                  95      


Gln Val Leu Trp Lys Leu Leu Lys Val Val Lys Phe Gly Glu Val Ile 
            100                 105                 110         


Ser Tyr Ser His Leu Ala Ala Leu Ala Gly Asn Pro Ala Ala Thr Ala 
        115                 120                 125             


Ala Val Lys Thr Ala Leu Ser Gly Asn Pro Val Pro Ile Leu Ile Pro 
    130                 135                 140                 


Cys His Arg Val Val Gln Gly Asp Leu Asp Val Gly Gly Tyr Glu Gly 
145                 150                 155                 160 


Gly Leu Ala Val Lys Glu Trp Leu Leu Ala His Glu Gly His Arg Leu 
                165                 170                 175     


Gly Lys Pro Gly Leu Gly 
            180         


<210> 6
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 6
Asp Tyr Lys Asp Asp Asp Asp Lys Gly 
1               5                   


<210> 7
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 7
Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu 
1               5                   10  


<210> 8
<211> 307
<212> PRT
<213> Homo sapiens

<400> 8
Ile Leu Asp Tyr Ser Phe Gly Gly Gly Ala Gly Arg Asp Ile Pro Pro 
1               5                   10                  15      


Pro Leu Ile Glu Glu Ala Cys Glu Leu Pro Glu Cys Gln Glu Asp Ala 
            20                  25                  30          


Gly Asn Lys Val Cys Ser Leu Gln Cys Asn Asn His Ala Cys Gly Trp 
        35                  40                  45              


Asp Gly Gly Asp Cys Ser Leu Asn Phe Asn Asp Pro Trp Lys Asn Cys 
    50                  55                  60                  


Thr Gln Ser Leu Gln Cys Trp Lys Tyr Phe Ser Asp Gly His Cys Asp 
65                  70                  75                  80  


Ser Gln Cys Asn Ser Ala Gly Cys Leu Phe Asp Gly Phe Asp Cys Gln 
                85                  90                  95      


Arg Ala Glu Gly Gln Cys Asn Pro Leu Tyr Asp Gln Tyr Cys Lys Asp 
            100                 105                 110         


His Phe Ser Asp Gly His Cys Asp Gln Gly Cys Asn Ser Ala Glu Cys 
        115                 120                 125             


Glu Trp Asp Gly Leu Asp Cys Ala Glu His Val Pro Glu Arg Leu Ala 
    130                 135                 140                 


Ala Gly Thr Leu Val Val Val Val Leu Met Pro Pro Glu Gln Leu Arg 
145                 150                 155                 160 


Asn Ser Ser Phe His Phe Leu Arg Glu Leu Ser Arg Val Leu His Thr 
                165                 170                 175     


Asn Val Val Phe Lys Arg Asp Ala His Gly Gln Gln Met Ile Phe Pro 
            180                 185                 190         


Tyr Tyr Gly Arg Glu Glu Glu Leu Arg Lys His Pro Ile Lys Arg Ala 
        195                 200                 205             


Ala Glu Gly Trp Ala Ala Pro Asp Ala Leu Leu Gly Gln Val Lys Ala 
    210                 215                 220                 


Ser Leu Leu Pro Gly Gly Ser Glu Gly Gly Arg Arg Arg Arg Glu Leu 
225                 230                 235                 240 


Asp Pro Met Asp Val Arg Gly Ser Ile Val Tyr Leu Glu Ile Asp Asn 
                245                 250                 255     


Arg Gln Cys Val Gln Ala Ser Ser Gln Cys Phe Gln Ser Ala Thr Asp 
            260                 265                 270         


Val Ala Ala Phe Leu Gly Ala Leu Ala Ser Leu Gly Ser Leu Asn Ile 
        275                 280                 285             


Pro Tyr Lys Ile Glu Ala Val Gln Ser Glu Thr Val Glu Pro Pro Pro 
    290                 295                 300                 


Pro Ala Gln 
305         


<210> 9
<211> 297
<212> PRT
<213> Mus sp.

<400> 9
Ile Leu Asp Tyr Ser Phe Thr Gly Gly Ala Gly Arg Asp Ile Pro Pro 
1               5                   10                  15      


Pro Gln Ile Glu Glu Ala Cys Glu Leu Pro Glu Cys Gln Val Asp Ala 
            20                  25                  30          


Gly Asn Lys Val Cys Asn Leu Gln Cys Asn Asn His Ala Cys Gly Trp 
        35                  40                  45              


Asp Gly Gly Asp Cys Ser Leu Asn Phe Asn Asp Pro Trp Lys Asn Cys 
    50                  55                  60                  


Thr Gln Ser Leu Gln Cys Trp Lys Tyr Phe Ser Asp Gly His Cys Asp 
65                  70                  75                  80  


Ser Gln Cys Asn Ser Ala Gly Cys Leu Phe Asp Gly Phe Asp Cys Gln 
                85                  90                  95      


Leu Thr Glu Gly Gln Cys Asn Pro Leu Tyr Asp Gln Tyr Cys Lys Asp 
            100                 105                 110         


His Phe Ser Asp Gly His Cys Asp Gln Gly Cys Asn Ser Ala Glu Cys 
        115                 120                 125             


Glu Trp Asp Gly Leu Asp Cys Ala Glu His Val Pro Glu Arg Leu Ala 
    130                 135                 140                 


Ala Gly Thr Leu Val Leu Val Val Leu Leu Pro Pro Asp Gln Leu Arg 
145                 150                 155                 160 


Asn Asn Ser Phe His Phe Leu Arg Glu Leu Ser His Val Leu His Thr 
                165                 170                 175     


Asn Val Val Phe Lys Arg Asp Ala Gln Gly Gln Gln Met Ile Phe Pro 
            180                 185                 190         


Tyr Tyr Gly His Glu Glu Glu Leu Arg Lys His Pro Ile Lys Arg Ser 
        195                 200                 205             


Thr Val Gly Trp Ala Thr Ser Ser Leu Leu Pro Gly Thr Ser Gly Gly 
    210                 215                 220                 


Arg Gln Arg Arg Glu Leu Asp Pro Met Asp Ile Arg Gly Ser Ile Val 
225                 230                 235                 240 


Tyr Leu Glu Ile Asp Asn Arg Gln Cys Val Gln Ser Ser Ser Gln Cys 
                245                 250                 255     


Phe Gln Ser Ala Thr Asp Val Ala Ala Phe Leu Gly Ala Leu Ala Ser 
            260                 265                 270         


Leu Gly Ser Leu Asn Ile Pro Tyr Lys Ile Glu Ala Val Lys Ser Glu 
        275                 280                 285             


Pro Val Glu Pro Pro Leu Pro Ser Gln 
    290                 295         


<210> 10
<211> 265
<212> PRT
<213> Mus sp.

<400> 10
Leu Tyr Thr Ala Pro Pro Ser Thr Pro Pro Ala Thr Cys Leu Ser Gln 
1               5                   10                  15      


Tyr Cys Ala Asp Lys Ala Arg Asp Gly Val Cys Asp Glu Ala Cys Asn 
            20                  25                  30          


Ser His Ala Cys Gln Trp Asp Gly Gly Asp Cys Ser Leu Thr Met Glu 
        35                  40                  45              


Asn Pro Trp Ala Asn Cys Ser Ser Pro Leu Pro Cys Trp Asp Tyr Ile 
    50                  55                  60                  


Asn Asn Gln Cys Asp Glu Leu Cys Asn Thr Val Glu Cys Leu Phe Asp 
65                  70                  75                  80  


Asn Phe Glu Cys Gln Gly Asn Ser Lys Thr Cys Lys Tyr Asp Lys Tyr 
                85                  90                  95      


Cys Ala Asp His Phe Lys Asp Asn His Cys Asp Gln Gly Cys Asn Ser 
            100                 105                 110         


Glu Glu Cys Gly Trp Asp Gly Leu Asp Cys Ala Ala Asp Gln Pro Glu 
        115                 120                 125             


Asn Leu Ala Glu Gly Thr Leu Val Ile Val Val Leu Met Pro Pro Glu 
    130                 135                 140                 


Gln Leu Leu Gln Asp Ala Arg Ser Phe Leu Arg Ala Leu Gly Thr Leu 
145                 150                 155                 160 


Leu His Thr Asn Leu Arg Ile Lys Arg Asp Ser Gln Gly Glu Leu Met 
                165                 170                 175     


Val Tyr Pro Tyr Tyr Gly Glu Lys Ser Ala Ala Met Lys Lys Gln Arg 
            180                 185                 190         


Met Thr Arg Arg Ser Leu Pro Gly Glu Gln Glu Gln Glu Val Ala Gly 
        195                 200                 205             


Ser Lys Val Phe Leu Glu Ile Asp Asn Arg Gln Cys Val Gln Asp Ser 
    210                 215                 220                 


Asp His Cys Phe Lys Asn Thr Asp Ala Ala Ala Ala Leu Leu Ala Ser 
225                 230                 235                 240 


His Ala Ile Gln Gly Thr Leu Ser Tyr Pro Leu Val Ser Val Val Ser 
                245                 250                 255     


Glu Ser Leu Thr Pro Glu Arg Thr Gln 
            260                 265 


<210> 11
<211> 793
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      NICD sequence

<400> 11
Gln His Gly Gln Leu Trp Phe Pro Glu Gly Phe Lys Val Ser Glu Ala 
1               5                   10                  15      


Ser Lys Lys Lys Arg Arg Glu Pro Leu Gly Glu Asp Ser Val Gly Leu 
            20                  25                  30          


Lys Pro Leu Lys Asn Ala Ser Asp Gly Ala Leu Met Asp Asp Asn Gln 
        35                  40                  45              


Asn Glu Trp Gly Asp Glu Asp Leu Glu Thr Lys Lys Phe Arg Phe Glu 
    50                  55                  60                  


Glu Pro Val Val Leu Pro Asp Leu Asp Asp Gln Thr Asp His Arg Gln 
65                  70                  75                  80  


Trp Thr Gln Gln His Leu Asp Ala Ala Asp Leu Arg Met Ser Ala Met 
                85                  90                  95      


Ala Pro Thr Pro Pro Gln Gly Glu Val Asp Ala Asp Cys Met Asp Val 
            100                 105                 110         


Asn Val Arg Gly Pro Asp Gly Phe Thr Pro Leu Met Ile Ala Ser Cys 
        115                 120                 125             


Ser Gly Gly Gly Leu Glu Thr Gly Asn Ser Glu Glu Glu Glu Asp Ala 
    130                 135                 140                 


Pro Ala Val Ile Ser Asp Phe Ile Tyr Gln Gly Ala Ser Leu His Asn 
145                 150                 155                 160 


Gln Thr Asp Arg Thr Gly Glu Thr Ala Leu His Leu Ala Ala Arg Tyr 
                165                 170                 175     


Ser Arg Ser Asp Ala Ala Lys Arg Leu Leu Glu Ala Ser Ala Asp Ala 
            180                 185                 190         


Asn Ile Gln Asp Asn Met Gly Arg Thr Pro Leu His Ala Ala Val Ser 
        195                 200                 205             


Ala Asp Ala Gln Gly Val Phe Gln Ile Leu Ile Arg Asn Arg Ala Thr 
    210                 215                 220                 


Asp Leu Asp Ala Arg Met His Asp Gly Thr Thr Pro Leu Ile Leu Ala 
225                 230                 235                 240 


Ala Arg Leu Ala Val Glu Gly Met Leu Glu Asp Leu Ile Asn Ser His 
                245                 250                 255     


Ala Asp Val Asn Ala Val Asp Asp Leu Gly Lys Ser Ala Leu His Trp 
            260                 265                 270         


Ala Ala Ala Val Asn Asn Val Asp Ala Ala Val Val Leu Leu Lys Asn 
        275                 280                 285             


Gly Ala Asn Lys Asp Met Gln Asn Asn Arg Glu Glu Thr Pro Leu Phe 
    290                 295                 300                 


Leu Ala Ala Arg Glu Gly Ser Tyr Glu Thr Ala Lys Val Leu Leu Asp 
305                 310                 315                 320 


His Phe Ala Asn Arg Asp Ile Thr Asp His Met Asp Arg Leu Pro Arg 
                325                 330                 335     


Asp Ile Ala Gln Glu Arg Met His His Asp Ile Val Arg Leu Leu Asp 
            340                 345                 350         


Glu Tyr Asn Leu Val Arg Ser Pro Gln Leu His Gly Ala Pro Leu Gly 
        355                 360                 365             


Gly Thr Pro Thr Leu Ser Pro Pro Leu Cys Ser Pro Asn Gly Tyr Leu 
    370                 375                 380                 


Gly Ser Leu Lys Pro Gly Val Gln Gly Lys Lys Val Arg Lys Pro Ser 
385                 390                 395                 400 


Ser Lys Gly Leu Ala Cys Gly Ser Lys Glu Ala Lys Asp Leu Lys Ala 
                405                 410                 415     


Arg Arg Lys Lys Ser Gln Asp Gly Lys Gly Cys Leu Leu Asp Ser Ser 
            420                 425                 430         


Gly Met Leu Ser Pro Val Asp Ser Leu Glu Ser Pro His Gly Tyr Leu 
        435                 440                 445             


Ser Asp Val Ala Ser Pro Pro Leu Leu Pro Ser Pro Phe Gln Gln Ser 
    450                 455                 460                 


Pro Ser Val Pro Leu Asn His Leu Pro Gly Met Pro Asp Thr His Leu 
465                 470                 475                 480 


Gly Ile Gly His Leu Asn Val Ala Ala Lys Pro Glu Met Ala Ala Leu 
                485                 490                 495     


Gly Gly Gly Gly Arg Leu Ala Phe Glu Thr Gly Pro Pro Arg Leu Ser 
            500                 505                 510         


His Leu Pro Val Ala Ser Gly Thr Ser Thr Val Leu Gly Ser Ser Ser 
        515                 520                 525             


Gly Gly Ala Leu Asn Phe Thr Val Gly Gly Ser Thr Ser Leu Asn Gly 
    530                 535                 540                 


Gln Cys Glu Trp Leu Ser Arg Leu Gln Ser Gly Met Val Pro Asn Gln 
545                 550                 555                 560 


Tyr Asn Pro Leu Arg Gly Ser Val Ala Pro Gly Pro Leu Ser Thr Gln 
                565                 570                 575     


Ala Pro Ser Leu Gln His Gly Met Val Gly Pro Leu His Ser Ser Leu 
            580                 585                 590         


Ala Ala Ser Ala Leu Ser Gln Met Met Ser Tyr Gln Gly Leu Pro Ser 
        595                 600                 605             


Thr Arg Leu Ala Thr Gln Pro His Leu Val Gln Thr Gln Gln Val Gln 
    610                 615                 620                 


Pro Gln Asn Leu Gln Met Gln Gln Gln Asn Leu Gln Pro Ala Asn Ile 
625                 630                 635                 640 


Gln Gln Gln Gln Ser Leu Gln Pro Pro Pro Pro Pro Pro Gln Pro His 
                645                 650                 655     


Leu Gly Val Ser Ser Ala Ala Ser Gly His Leu Gly Arg Ser Phe Leu 
            660                 665                 670         


Ser Gly Glu Pro Ser Gln Ala Asp Val Gln Pro Leu Gly Pro Ser Ser 
        675                 680                 685             


Leu Ala Val His Thr Ile Leu Pro Gln Glu Ser Pro Ala Leu Pro Thr 
    690                 695                 700                 


Ser Leu Pro Ser Ser Leu Val Pro Pro Val Thr Ala Ala Gln Phe Leu 
705                 710                 715                 720 


Thr Pro Pro Ser Gln His Ser Tyr Ser Ser Pro Val Asp Asn Thr Pro 
                725                 730                 735     


Ser His Gln Leu Gln Val Pro Glu His Pro Phe Leu Thr Pro Ser Pro 
            740                 745                 750         


Glu Ser Pro Asp Gln Trp Ser Ser Ser Ser Pro His Ser Asn Val Ser 
        755                 760                 765             


Asp Trp Ser Glu Gly Val Ser Ser Pro Pro Thr Ser Met Gln Ser Gln 
    770                 775                 780                 


Ile Ala Arg Ile Pro Glu Ala Phe Lys 
785                 790             


<210> 12
<211> 211
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      Gal4DBD-VP64 sequence

<400> 12
Met Lys Leu Leu Ser Ser Ile Glu Gln Ala Cys Asp Ile Cys Arg Leu 
1               5                   10                  15      


Lys Lys Leu Lys Cys Ser Lys Glu Lys Pro Lys Cys Ala Lys Cys Leu 
            20                  25                  30          


Lys Asn Asn Trp Glu Cys Arg Tyr Ser Pro Lys Thr Lys Arg Ser Pro 
        35                  40                  45              


Leu Thr Arg Ala His Leu Thr Glu Val Glu Ser Arg Leu Glu Arg Leu 
    50                  55                  60                  


Glu Gln Leu Phe Leu Leu Ile Phe Pro Arg Glu Asp Leu Asp Met Ile 
65                  70                  75                  80  


Leu Lys Met Asp Ser Leu Gln Asp Ile Lys Ala Leu Leu Thr Gly Leu 
                85                  90                  95      


Phe Val Gln Asp Asn Val Asn Lys Asp Ala Val Thr Asp Arg Leu Ala 
            100                 105                 110         


Ser Val Glu Thr Asp Met Pro Leu Thr Leu Arg Gln His Arg Ile Ser 
        115                 120                 125             


Ala Thr Ser Ser Ser Glu Glu Ser Ser Asn Lys Gly Gln Arg Gln Leu 
    130                 135                 140                 


Thr Val Ser Ala Ala Ala Gly Gly Ser Gly Gly Ser Gly Gly Ser Asp 
145                 150                 155                 160 


Ala Leu Asp Asp Phe Asp Leu Asp Met Leu Gly Ser Asp Ala Leu Asp 
                165                 170                 175     


Asp Phe Asp Leu Asp Met Leu Gly Ser Asp Ala Leu Asp Asp Phe Asp 
            180                 185                 190         


Leu Asp Met Leu Gly Ser Asp Ala Leu Asp Asp Phe Asp Leu Asp Met 
        195                 200                 205             


Leu Gly Ser 
    210     


<210> 13
<211> 29
<212> PRT
<213> Homo sapiens

<400> 13
Leu His Phe Met Tyr Val Ala Ala Ala Ala Phe Val Leu Leu Phe Phe 
1               5                   10                  15      


Val Gly Cys Gly Val Leu Leu Ser Arg Lys Arg Arg Arg 
            20                  25                  


<210> 14
<211> 29
<212> PRT
<213> Mus sp.

<400> 14
Leu His Leu Met Tyr Val Ala Ala Ala Ala Phe Val Leu Leu Phe Phe 
1               5                   10                  15      


Val Gly Cys Gly Val Leu Leu Ser Arg Lys Arg Arg Arg 
            20                  25                  


<210> 15
<211> 244
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 15
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Trp Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Asn Pro Pro Asn Arg Ser Asn Gln Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Ser Gly Phe Arg Trp Val Met Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Gly Gly Ser Ser Arg Ser Ser Ser Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Asp Ile Gln Met Thr Gln Ser 
    130                 135                 140                 


Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys 
145                 150                 155                 160 


Arg Ala Ser Gln Asp Val Ser Thr Ala Val Ala Trp Tyr Gln Gln Lys 
                165                 170                 175     


Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ser Ala Ser Phe Leu Tyr 
            180                 185                 190         


Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 
        195                 200                 205             


Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr 
    210                 215                 220                 


Cys Gln Gln Phe Tyr Thr Thr Pro Ser Thr Phe Gly Gln Gly Thr Lys 
225                 230                 235                 240 


Val Glu Ile Lys 
                


<210> 16
<211> 244
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 16
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Trp Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Asn Pro Pro Ala Arg Ser Asn Gln Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Ser Gly Phe Arg Trp Val Met Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Gly Gly Ser Ser Arg Ser Ser Ser Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Asp Ile Gln Met Thr Gln Ser 
    130                 135                 140                 


Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys 
145                 150                 155                 160 


Arg Ala Ser Gln Asp Val Ser Thr Ala Val Ala Trp Tyr Gln Gln Lys 
                165                 170                 175     


Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ser Ala Ser Phe Leu Tyr 
            180                 185                 190         


Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 
        195                 200                 205             


Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr 
    210                 215                 220                 


Cys Gln Gln Phe Tyr Thr Thr Pro Ser Thr Phe Gly Gln Gly Thr Lys 
225                 230                 235                 240 


Val Glu Ile Lys 
                


<210> 17
<211> 244
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 17
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Trp Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Asn Pro Pro Asn Arg Ser Asn Gln Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Ser Gly Phe Lys Trp Val Met Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Gly Gly Ser Ser Arg Ser Ser Ser Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Asp Ile Gln Met Thr Gln Ser 
    130                 135                 140                 


Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys 
145                 150                 155                 160 


Arg Ala Ser Gln Asp Val Ser Thr Ala Val Ala Trp Tyr Gln Gln Lys 
                165                 170                 175     


Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ser Ala Ser Phe Leu Tyr 
            180                 185                 190         


Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 
        195                 200                 205             


Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr 
    210                 215                 220                 


Cys Gln Gln Phe Tyr Thr Thr Pro Ser Thr Phe Gly Gln Gly Thr Lys 
225                 230                 235                 240 


Val Glu Ile Lys 
                


<210> 18
<211> 244
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 18
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Trp Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Asn Pro Pro Asn Arg Ser Asn Gln Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Ser Gly Phe Ala Trp Val Met Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Gly Gly Ser Ser Arg Ser Ser Ser Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Asp Ile Gln Met Thr Gln Ser 
    130                 135                 140                 


Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys 
145                 150                 155                 160 


Arg Ala Ser Gln Asp Val Ser Thr Ala Val Ala Trp Tyr Gln Gln Lys 
                165                 170                 175     


Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ser Ala Ser Phe Leu Tyr 
            180                 185                 190         


Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 
        195                 200                 205             


Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr 
    210                 215                 220                 


Cys Gln Gln Phe Tyr Thr Thr Pro Ser Thr Phe Gly Gln Gly Thr Lys 
225                 230                 235                 240 


Val Glu Ile Lys 
                


<210> 19
<211> 244
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 19
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Ser Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Trp Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Asn Pro Pro Asn Arg Ser Asn Gln Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Ala 
                85                  90                  95      


Ala Arg Gly Ser Gly Phe Arg Trp Val Met Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Gly Gly Ser Ser Arg Ser Ser Ser Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Asp Ile Gln Met Thr Gln Ser 
    130                 135                 140                 


Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys 
145                 150                 155                 160 


Arg Ala Ser Gln Asp Val Ser Thr Ala Val Ala Trp Tyr Gln Gln Lys 
                165                 170                 175     


Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ser Ala Ser Phe Leu Tyr 
            180                 185                 190         


Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 
        195                 200                 205             


Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr 
    210                 215                 220                 


Cys Gln Gln Phe Tyr Thr Thr Pro Ser Thr Phe Gly Gln Gly Thr Lys 
225                 230                 235                 240 


Val Glu Ile Lys 
                


<210> 20
<211> 244
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 20
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Trp Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Asn Pro Pro Asn Arg Ser Asn Gln Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Ser Gly Phe Arg Trp Val Met Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Gly Gly Ser Ser Arg Ser Ser Ser Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Asp Ile Gln Met Thr Gln Ser 
    130                 135                 140                 


Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys 
145                 150                 155                 160 


Arg Ala Ser Gln Asp Val Ala Thr Ala Val Ala Trp Tyr Gln Gln Lys 
                165                 170                 175     


Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ser Ala Ser Phe Leu Tyr 
            180                 185                 190         


Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 
        195                 200                 205             


Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr 
    210                 215                 220                 


Cys Gln Gln Phe Tyr Thr Thr Pro Ser Thr Phe Gly Gln Gly Thr Lys 
225                 230                 235                 240 


Val Glu Ile Lys 
                


<210> 21
<211> 244
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 21
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Trp Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Asn Pro Pro Asn Arg Ser Asn Gln Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Ser Gly Phe Arg Trp Val Met Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Gly Gly Ser Ser Arg Ser Ser Ser Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Asp Ile Gln Met Thr Gln Ser 
    130                 135                 140                 


Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys 
145                 150                 155                 160 


Arg Ala Ser Gln Asp Val Ser Thr Ala Val Ala Trp Tyr Gln Gln Lys 
                165                 170                 175     


Pro Gly Lys Ala Pro Lys Leu Leu Ile Ala Ser Ala Ser Phe Leu Tyr 
            180                 185                 190         


Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 
        195                 200                 205             


Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr 
    210                 215                 220                 


Cys Gln Gln Phe Tyr Thr Thr Pro Ser Thr Phe Gly Gln Gly Thr Lys 
225                 230                 235                 240 


Val Glu Ile Lys 
                


<210> 22
<211> 244
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 22
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Trp Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Asn Pro Pro Asn Arg Ser Asn Gln Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Ser Gly Phe Arg Trp Val Met Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Gly Gly Ser Ser Arg Ser Ser Ser Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Asp Ile Gln Met Thr Gln Ser 
    130                 135                 140                 


Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys 
145                 150                 155                 160 


Arg Ala Ser Gln Asp Val Ser Thr Ala Val Ala Trp Tyr Gln Gln Lys 
                165                 170                 175     


Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ser Ala Ser Phe Leu Ala 
            180                 185                 190         


Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 
        195                 200                 205             


Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr 
    210                 215                 220                 


Cys Gln Gln Phe Tyr Thr Thr Pro Ser Thr Phe Gly Gln Gly Thr Lys 
225                 230                 235                 240 


Val Glu Ile Lys 
                


<210> 23
<211> 244
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 23
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Trp Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Asn Pro Pro Asn Arg Ser Asn Gln Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Ser Gly Phe Arg Trp Val Met Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Gly Gly Ser Ser Arg Ser Ser Ser Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Asp Ile Gln Met Thr Gln Ser 
    130                 135                 140                 


Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys 
145                 150                 155                 160 


Arg Ala Ser Gln Asp Val Ser Thr Ala Val Ala Trp Tyr Gln Gln Lys 
                165                 170                 175     


Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ser Ala Ser Phe Leu Tyr 
            180                 185                 190         


Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 
        195                 200                 205             


Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr 
    210                 215                 220                 


Cys Gln Gln Ala Tyr Thr Thr Pro Ser Thr Phe Gly Gln Gly Thr Lys 
225                 230                 235                 240 


Val Glu Ile Lys 
                


<210> 24
<211> 244
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 24
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Trp Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Asn Pro Pro Asn Arg Ser Asn Gln Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Ser Gly Phe Arg Trp Val Met Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Gly Gly Ser Ser Arg Ser Ser Ser Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Asp Ile Gln Met Thr Gln Ser 
    130                 135                 140                 


Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys 
145                 150                 155                 160 


Arg Ala Ser Gln Asp Val Ser Thr Ala Val Ala Trp Tyr Gln Gln Lys 
                165                 170                 175     


Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ser Ala Ser Phe Leu Tyr 
            180                 185                 190         


Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 
        195                 200                 205             


Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr 
    210                 215                 220                 


Cys Gln Gln Phe Ala Thr Thr Pro Ser Thr Phe Gly Gln Gly Thr Lys 
225                 230                 235                 240 


Val Glu Ile Lys 
                


<210> 25
<211> 251
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 25
Gln Val Gln Leu Val Glu Ser Gly Gly Asn Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Gly Ser Phe 
            20                  25                  30          


Ser Met Ser Trp Val Arg Gln Ala Pro Gly Gly Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Gly Leu Ser Ala Arg Ser Ser Leu Thr His Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Val Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg Ser Tyr Asp Ser Ser Gly Tyr Ala Gly His Phe Tyr Ser 
            100                 105                 110         


Tyr Met Asp Val Trp Gly Gln Gly Thr Leu Val Thr Val Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser Val Leu 
    130                 135                 140                 


Thr Gln Pro Ser Ser Val Ser Ala Ala Pro Gly Gln Lys Val Thr Ile 
145                 150                 155                 160 


Ser Cys Ser Gly Ser Thr Ser Asn Ile Gly Asn Asn Tyr Val Ser Trp 
                165                 170                 175     


Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu Met Ile Tyr Asp Val 
            180                 185                 190         


Ser Lys Arg Pro Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Lys Ser 
        195                 200                 205             


Gly Asn Ser Ala Ser Leu Asp Ile Ser Gly Leu Gln Ser Glu Asp Glu 
    210                 215                 220                 


Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu Ser Glu Phe Leu 
225                 230                 235                 240 


Phe Gly Thr Gly Thr Lys Leu Thr Val Leu Gly 
                245                 250     


<210> 26
<211> 250
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 26
Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Leu Ser Ser Tyr 
            20                  25                  30          


Thr Val Ser Trp Leu Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Arg Ile Ile Pro Ile Leu Asp Arg Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Asn Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Ile Gly Ala Ala Gly Asp Gly Val Trp Phe Asp Pro Trp 
            100                 105                 110         


Gly Gln Gly Thr Met Val Thr Val Ser Ser Gly Gly Ser Ser Arg Ser 
        115                 120                 125             


Ser Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Gln Ala Val Leu 
    130                 135                 140                 


Thr Gln Pro Ser Ser Val Ser Gly Ala Pro Gly Gln Arg Val Thr Ile 
145                 150                 155                 160 


Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly Tyr Asp Val His 
                165                 170                 175     


Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu Ile Phe Asp 
            180                 185                 190         


Asn Lys Asn Arg Pro Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Asn 
        195                 200                 205             


Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu Gln Ala Glu Asp 
    210                 215                 220                 


Glu Ala Glu Tyr Tyr Cys Gln Ser Tyr Asp Asn Asn Leu Ser Gly Arg 
225                 230                 235                 240 


Val Phe Gly Gly Gly Thr Lys Leu Thr Val 
                245                 250 


<210> 27
<211> 239
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 27
Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
1               5                   10                  15      


Phe Thr Phe Asp Asp Tyr Ala Met His Trp Val Arg Gln Ala Pro Gly 
            20                  25                  30          


Lys Gly Leu Glu Trp Val Ser Ser Ile Ser Trp His Ser Arg Thr Ile 
        35                  40                  45              


Ala Tyr Ala Asp Ser Val Lys Gly Arg Phe Ser Ile Ser Arg Asp Asn 
    50                  55                  60                  


Ala Lys Asn Ser Leu Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu Asp 
65                  70                  75                  80  


Thr Ala Val Tyr Tyr Cys Ala Lys Ala Ser Tyr Leu Ser Thr Ser Ser 
                85                  90                  95      


Ser Leu Asp Tyr Trp Gly Arg Gly Thr Leu Val Thr Val Ser Ser Gly 
            100                 105                 110         


Gly Ser Ser Arg Ser Ser Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Gln Ser Val Leu Thr Gln Pro Gly Ser Val Ser Gly Ser Pro Gly 
    130                 135                 140                 


Gln Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Gly 
145                 150                 155                 160 


Tyr Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys 
                165                 170                 175     


Leu Met Ile Tyr Glu Gly Ser Lys Arg Pro Ser Gly Val Ser Asn Arg 
            180                 185                 190         


Phe Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly 
        195                 200                 205             


Leu Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Thr Thr 
    210                 215                 220                 


Arg Ser Thr Arg Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
225                 230                 235                 


<210> 28
<211> 250
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 28
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Tyr Pro Tyr Ser Gly Ala Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg His Ser Gly Tyr Tyr Arg Ile Ser Ser Ala Met Asp Val Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ala Gly Gly Ser Ser Arg Ser 
        115                 120                 125             


Ser Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Asp Ile Gln Met 
    130                 135                 140                 


Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr 
145                 150                 155                 160 


Ile Thr Cys Arg Ala Ser Gln Asn Ile Lys Arg Phe Leu Ala Trp Tyr 
                165                 170                 175     


Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Gly Ala Ser 
            180                 185                 190         


Thr Arg Glu Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly 
        195                 200                 205             


Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala 
    210                 215                 220                 


Thr Tyr Tyr Cys Gln Gln Tyr Tyr Arg Ser Pro His Thr Phe Gly Gln 
225                 230                 235                 240 


Gly Thr Lys Val Glu Ile Lys Arg Gly Gly 
                245                 250 


<210> 29
<211> 248
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 29
Ala Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly 
1               5                   10                  15      


Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser 
            20                  25                  30          


Tyr Ala Met His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp 
        35                  40                  45              


Met Gly Trp Met Asn Ala Gly Asn Gly Asn Thr Lys Tyr Ser Gln Lys 
    50                  55                  60                  


Phe Gln Gly Arg Val Thr Ile Thr Arg Asp Thr Ser Ala Ser Thr Ala 
65                  70                  75                  80  


Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Asp Arg Val Pro Thr Ile Pro Ala Tyr Arg Ile Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Leu Glu Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Ala Ser Asp Ile Gln Met 
    130                 135                 140                 


Thr Gln Ser Pro Ser Ser Val Ser Ala Ser Val Gly Asp Arg Val Thr 
145                 150                 155                 160 


Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Trp Leu Ala Trp Tyr 
                165                 170                 175     


Gln Gln Lys Pro Gly Lys Ala Pro Arg Leu Leu Ile Tyr Ala Ala Ser 
            180                 185                 190         


Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly 
        195                 200                 205             


Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala 
    210                 215                 220                 


Thr Tyr Tyr Cys Gln Gln Ala Asn Ser Phe Pro Leu Thr Phe Gly Gly 
225                 230                 235                 240 


Gly Thr Lys Leu Glu Ile Lys Arg 
                245             


<210> 30
<211> 247
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 30
Ala Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly 
1               5                   10                  15      


Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser 
            20                  25                  30          


Tyr Ala Met His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp 
        35                  40                  45              


Met Gly Trp Ile Asn Ala Gly Asn Gly Asn Thr Lys Tyr Ser Gln Lys 
    50                  55                  60                  


Phe Gln Gly Arg Val Thr Ile Thr Arg Asp Thr Ser Ala Ser Thr Ala 
65                  70                  75                  80  


Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Gly Pro Arg Ser Tyr Gly Ala Gly Gly Met Asp Val Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Leu Glu Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Ala Ser Asp Ile Gln Met Thr 
    130                 135                 140                 


Gln Ser Pro Ser Ser Val Ser Ala Ser Val Gly Asp Arg Val Thr Ile 
145                 150                 155                 160 


Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Trp Leu Ala Trp Tyr Gln 
                165                 170                 175     


Gln Lys Pro Gly Lys Ala Pro Lys Phe Leu Ile Tyr Ala Ala Ser Ser 
            180                 185                 190         


Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr 
        195                 200                 205             


Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr 
    210                 215                 220                 


Tyr Tyr Cys Gln Gln Ala Asn Ser Phe Pro Leu Thr Phe Gly Gly Gly 
225                 230                 235                 240 


Thr Lys Val Glu Ile Lys Arg 
                245         


<210> 31
<211> 51
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      Platelet Derived Growth Factor Receptor (PDGFR) TM domain

<400> 31
Ala Val Gly Gln Asp Thr Gln Glu Val Ile Val Val Pro His Ser Leu 
1               5                   10                  15      


Pro Phe Lys Val Val Val Ile Ser Ala Ile Leu Ala Leu Val Val Leu 
            20                  25                  30          


Thr Ile Ile Ser Leu Ile Ile Leu Ile Met Leu Trp Gln Lys Lys Pro 
        35                  40                  45              


Arg Arg Thr 
    50      


<210> 32
<211> 265
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 32
Glu Asp Val Val Cys Cys His Ser Ile Tyr Gly Lys Lys Lys Gly Asp 
1               5                   10                  15      


Ile Asp Thr Tyr Arg Tyr Ile Gly Ser Ser Gly Thr Gly Cys Val Val 
            20                  25                  30          


Ile Val Gly Arg Ile Val Leu Ser Gly Ser Gly Thr Ser Ala Pro Ile 
        35                  40                  45              


Thr Ala Tyr Ala Gln Gln Thr Arg Gly Leu Leu Gly Cys Ile Ile Thr 
    50                  55                  60                  


Ser Leu Thr Gly Arg Asp Lys Asn Gln Val Glu Gly Glu Val Gln Ile 
65                  70                  75                  80  


Val Ser Thr Ala Thr Gln Thr Phe Leu Ala Thr Cys Ile Asn Gly Val 
                85                  90                  95      


Cys Trp Ala Val Tyr His Gly Ala Gly Thr Arg Thr Ile Ala Ser Pro 
            100                 105                 110         


Lys Gly Pro Val Ile Gln Met Tyr Thr Asn Val Asp Gln Asp Leu Val 
        115                 120                 125             


Gly Trp Pro Ala Pro Gln Gly Ser Arg Ser Leu Thr Pro Cys Thr Cys 
    130                 135                 140                 


Gly Ser Ser Asp Leu Tyr Leu Val Thr Arg His Ala Asp Val Ile Pro 
145                 150                 155                 160 


Val Arg Arg Arg Gly Asp Ser Arg Gly Ser Leu Leu Ser Pro Arg Pro 
                165                 170                 175     


Ile Ser Tyr Leu Lys Gly Ser Ser Gly Gly Pro Leu Leu Cys Pro Ala 
            180                 185                 190         


Gly His Ala Val Gly Leu Phe Arg Ala Ala Val Cys Thr Arg Gly Val 
        195                 200                 205             


Ala Lys Ala Val Asp Phe Ile Pro Val Glu Asn Leu Glu Thr Thr Met 
    210                 215                 220                 


Arg Ser Pro Val Phe Thr Asp Asn Ser Ser Pro Pro Ala Val Thr Leu 
225                 230                 235                 240 


Thr His Pro Ile Thr Lys Ile Asp Arg Glu Val Leu Tyr Gln Glu Phe 
                245                 250                 255     


Asp Glu Met Glu Glu Cys Ser Gln His 
            260                 265 


<210> 33
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 33
Asp Thr Tyr Arg Tyr Ile 
1               5       


<210> 34
<211> 537
<212> PRT
<213> Rattus sp.

<400> 34
Met Gly Arg Arg Ser Ala Leu Ala Leu Ala Val Val Ser Ala Leu Leu 
1               5                   10                  15      


Cys Gln Val Trp Ser Ser Gly Val Phe Glu Leu Lys Leu Gln Glu Phe 
            20                  25                  30          


Val Asn Lys Lys Gly Leu Leu Gly Asn Arg Asn Cys Cys Arg Gly Gly 
        35                  40                  45              


Ser Gly Pro Pro Cys Ala Cys Arg Thr Phe Phe Arg Val Cys Leu Lys 
    50                  55                  60                  


His Tyr Gln Ala Ser Val Ser Pro Glu Pro Pro Cys Thr Tyr Gly Ser 
65                  70                  75                  80  


Ala Val Thr Ala Val Leu Gly Val Asp Ser Phe Ser Leu Pro Asp Gly 
                85                  90                  95      


Ala Gly Ile Asp Pro Ala Phe Ser Asn Pro Ile Arg Phe Pro Phe Gly 
            100                 105                 110         


Phe Thr Trp Pro Gly Thr Phe Ser Leu Ile Ile Glu Ala Leu His Thr 
        115                 120                 125             


Asp Ser Pro Asp Asp Leu Ala Thr Glu Asn Pro Glu Arg Leu Ile Ser 
    130                 135                 140                 


Arg Leu Thr Thr Gln Arg His Leu Thr Val Gly Glu Glu Trp Ser Gln 
145                 150                 155                 160 


Asp Leu His Ser Ser Gly Arg Thr Asp Leu Arg Tyr Ser Tyr Arg Phe 
                165                 170                 175     


Val Cys Asp Glu His Tyr Tyr Gly Glu Gly Cys Ser Val Phe Cys Arg 
            180                 185                 190         


Pro Arg Asp Asp Ala Phe Gly His Phe Thr Cys Gly Glu Arg Gly Glu 
        195                 200                 205             


Lys Met Cys Asp Pro Gly Trp Lys Gly Gln Tyr Cys Thr Asp Pro Ile 
    210                 215                 220                 


Cys Leu Pro Gly Cys Asp Asp Gln His Gly Tyr Cys Asp Lys Pro Gly 
225                 230                 235                 240 


Glu Cys Lys Cys Arg Val Gly Trp Gln Gly Arg Tyr Cys Asp Glu Cys 
                245                 250                 255     


Ile Arg Tyr Pro Gly Cys Leu His Gly Thr Cys Gln Gln Pro Trp Gln 
            260                 265                 270         


Cys Asn Cys Gln Glu Gly Trp Gly Gly Leu Phe Cys Asn Gln Asp Leu 
        275                 280                 285             


Asn Tyr Cys Thr His His Lys Pro Cys Arg Asn Gly Ala Thr Cys Thr 
    290                 295                 300                 


Asn Thr Gly Gln Gly Ser Tyr Thr Cys Ser Cys Arg Pro Gly Tyr Thr 
305                 310                 315                 320 


Gly Ala Asn Cys Glu Leu Glu Val Asp Glu Cys Ala Pro Ser Pro Cys 
                325                 330                 335     


Arg Asn Gly Gly Ser Cys Thr Asp Leu Glu Asp Ser Tyr Ser Cys Thr 
            340                 345                 350         


Cys Pro Pro Gly Phe Tyr Gly Lys Val Cys Glu Leu Ser Ala Met Thr 
        355                 360                 365             


Cys Ala Asp Gly Pro Cys Phe Asn Gly Gly Arg Cys Ser Asp Asn Pro 
    370                 375                 380                 


Asp Gly Gly Tyr Thr Cys His Cys Pro Ala Gly Phe Ser Gly Phe Asn 
385                 390                 395                 400 


Cys Glu Lys Lys Ile Asp Leu Cys Ser Ser Ser Pro Cys Ser Asn Gly 
                405                 410                 415     


Ala Lys Cys Val Asp Leu Gly Asn Ser Tyr Leu Cys Arg Cys Gln Thr 
            420                 425                 430         


Gly Phe Ser Gly Arg Tyr Cys Glu Asp Asn Val Asp Asp Cys Ala Ser 
        435                 440                 445             


Ser Pro Cys Ala Asn Gly Gly Thr Cys Arg Asp Ser Val Asn Asp Phe 
    450                 455                 460                 


Ser Cys Thr Cys Pro Pro Gly Tyr Thr Gly Arg Asn Cys Ser Ala Pro 
465                 470                 475                 480 


Val Ser Arg Cys Glu His Ala Pro Cys His Asn Gly Ala Thr Cys His 
                485                 490                 495     


Gln Arg Gly Gln Arg Tyr Met Cys Glu Cys Ala Gln Gly Tyr Gly Gly 
            500                 505                 510         


Ala Asn Cys Gln Phe Leu Leu Pro Glu Pro Pro Pro Asp Leu Ile Val 
        515                 520                 525             


Ala Ala Gln Gly Gly Ser Phe Pro Trp 
    530                 535         


<210> 35
<211> 177
<212> PRT
<213> Rattus sp.

<400> 35
Val Ala Val Cys Ala Gly Val Val Leu Val Leu Leu Leu Leu Leu Gly 
1               5                   10                  15      


Cys Ala Ala Val Val Val Cys Val Arg Leu Lys Leu Gln Lys His Gln 
            20                  25                  30          


Pro Pro Pro Asp Pro Cys Gly Gly Glu Thr Glu Thr Met Asn Asn Leu 
        35                  40                  45              


Ala Asn Cys Gln Arg Glu Lys Asp Val Ser Val Ser Ile Ile Gly Ala 
    50                  55                  60                  


Thr Gln Ile Lys Asn Thr Asn Lys Lys Ala Asp Phe His Gly Asp His 
65                  70                  75                  80  


Gly Ala Asp Lys Ser Ser Phe Lys Ala Arg Tyr Pro Thr Val Asp Tyr 
                85                  90                  95      


Asn Leu Ile Arg Asp Leu Lys Gly Asp Glu Ala Thr Val Arg Asp Ala 
            100                 105                 110         


His Ser Lys Arg Asp Thr Lys Cys Gln Ser Gln Gly Ser Val Gly Glu 
        115                 120                 125             


Glu Lys Ser Thr Ser Thr Leu Arg Gly Gly Glu Val Pro Asp Arg Lys 
    130                 135                 140                 


Arg Pro Glu Ser Val Tyr Ser Thr Ser Lys Asp Thr Lys Tyr Gln Ser 
145                 150                 155                 160 


Val Tyr Val Leu Ser Ala Glu Lys Asp Glu Cys Val Ile Ala Thr Glu 
                165                 170                 175     


Val 
    


<210> 36
<211> 529
<212> PRT
<213> Homo sapiens

<400> 36
Met Ala Ala Ala Ser Arg Ser Ala Ser Gly Trp Ala Leu Leu Leu Leu 
1               5                   10                  15      


Val Ala Leu Trp Gln Gln Arg Ala Ala Gly Ser Gly Val Phe Gln Leu 
            20                  25                  30          


Gln Leu Gln Glu Phe Ile Asn Glu Arg Gly Val Leu Ala Ser Gly Arg 
        35                  40                  45              


Pro Cys Glu Pro Gly Cys Arg Thr Phe Phe Arg Val Cys Leu Lys His 
    50                  55                  60                  


Phe Gln Ala Val Val Ser Pro Gly Pro Cys Thr Phe Gly Thr Val Ser 
65                  70                  75                  80  


Thr Pro Val Leu Gly Thr Asn Ser Phe Ala Val Arg Asp Asp Ser Ser 
                85                  90                  95      


Gly Gly Gly Arg Asn Pro Leu Gln Leu Pro Phe Asn Phe Thr Trp Pro 
            100                 105                 110         


Gly Thr Phe Ser Leu Ile Ile Glu Ala Trp His Ala Pro Gly Asp Asp 
        115                 120                 125             


Leu Arg Pro Glu Ala Leu Pro Pro Asp Ala Leu Ile Ser Lys Ile Ala 
    130                 135                 140                 


Ile Gln Gly Ser Leu Ala Val Gly Gln Asn Trp Leu Leu Asp Glu Gln 
145                 150                 155                 160 


Thr Ser Thr Leu Thr Arg Leu Arg Tyr Ser Tyr Arg Val Ile Cys Ser 
                165                 170                 175     


Asp Asn Tyr Tyr Gly Asp Asn Cys Ser Arg Leu Cys Lys Lys Arg Asn 
            180                 185                 190         


Asp His Phe Gly His Tyr Val Cys Gln Pro Asp Gly Asn Leu Ser Cys 
        195                 200                 205             


Leu Pro Gly Trp Thr Gly Glu Tyr Cys Gln Gln Pro Ile Cys Leu Ser 
    210                 215                 220                 


Gly Cys His Glu Gln Asn Gly Tyr Cys Ser Lys Pro Ala Glu Cys Leu 
225                 230                 235                 240 


Cys Arg Pro Gly Trp Gln Gly Arg Leu Cys Asn Glu Cys Ile Pro His 
                245                 250                 255     


Asn Gly Cys Arg His Gly Thr Cys Ser Thr Pro Trp Gln Cys Thr Cys 
            260                 265                 270         


Asp Glu Gly Trp Gly Gly Leu Phe Cys Asp Gln Asp Leu Asn Tyr Cys 
        275                 280                 285             


Thr His His Ser Pro Cys Lys Asn Gly Ala Thr Cys Ser Asn Ser Gly 
    290                 295                 300                 


Gln Arg Ser Tyr Thr Cys Thr Cys Arg Pro Gly Tyr Thr Gly Val Asp 
305                 310                 315                 320 


Cys Glu Leu Glu Leu Ser Glu Cys Asp Ser Asn Pro Cys Arg Asn Gly 
                325                 330                 335     


Gly Ser Cys Lys Asp Gln Glu Asp Gly Tyr His Cys Leu Cys Pro Pro 
            340                 345                 350         


Gly Tyr Tyr Gly Leu His Cys Glu His Ser Thr Leu Ser Cys Ala Asp 
        355                 360                 365             


Ser Pro Cys Phe Asn Gly Gly Ser Cys Arg Glu Arg Asn Gln Gly Ala 
    370                 375                 380                 


Asn Tyr Ala Cys Glu Cys Pro Pro Asn Phe Thr Gly Ser Asn Cys Glu 
385                 390                 395                 400 


Lys Lys Val Asp Arg Cys Thr Ser Asn Pro Cys Ala Asn Gly Gly Gln 
                405                 410                 415     


Cys Leu Asn Arg Gly Pro Ser Arg Met Cys Arg Cys Arg Pro Gly Phe 
            420                 425                 430         


Thr Gly Thr Tyr Cys Glu Leu His Val Ser Asp Cys Ala Arg Asn Pro 
        435                 440                 445             


Cys Ala His Gly Gly Thr Cys His Asp Leu Glu Asn Gly Leu Met Cys 
    450                 455                 460                 


Thr Cys Pro Ala Gly Phe Ser Gly Arg Arg Cys Glu Val Arg Thr Ser 
465                 470                 475                 480 


Ile Asp Ala Cys Ala Ser Ser Pro Cys Phe Asn Arg Ala Thr Cys Tyr 
                485                 490                 495     


Thr Asp Leu Ser Thr Asp Thr Phe Val Cys Asn Cys Pro Tyr Gly Phe 
            500                 505                 510         


Val Gly Ser Arg Cys Glu Phe Pro Val Gly Leu Pro Pro Ser Phe Pro 
        515                 520                 525             


Trp 
    


<210> 37
<211> 156
<212> PRT
<213> Homo sapiens

<400> 37
Val Ala Val Ser Leu Gly Val Gly Leu Ala Val Leu Leu Val Leu Leu 
1               5                   10                  15      


Gly Met Val Ala Val Ala Val Arg Gln Leu Arg Leu Arg Arg Pro Asp 
            20                  25                  30          


Asp Gly Ser Arg Glu Ala Met Asn Asn Leu Ser Asp Phe Gln Lys Asp 
        35                  40                  45              


Asn Leu Ile Pro Ala Ala Gln Leu Lys Asn Thr Asn Gln Lys Lys Glu 
    50                  55                  60                  


Leu Glu Val Asp Cys Gly Leu Asp Lys Ser Asn Cys Gly Lys Gln Gln 
65                  70                  75                  80  


Asn His Thr Leu Asp Tyr Asn Leu Ala Pro Gly Pro Leu Gly Arg Gly 
                85                  90                  95      


Thr Met Pro Gly Lys Phe Pro His Ser Asp Lys Ser Leu Gly Glu Lys 
            100                 105                 110         


Ala Pro Leu Arg Leu His Ser Glu Lys Pro Glu Cys Arg Ile Ser Ala 
        115                 120                 125             


Ile Cys Ser Pro Arg Asp Ser Met Tyr Gln Ser Val Cys Leu Ile Ser 
    130                 135                 140                 


Glu Glu Arg Asn Glu Cys Val Ile Ala Thr Glu Val 
145                 150                 155     


<210> 38
<211> 532
<212> PRT
<213> Mus sp.

<400> 38
Met Thr Pro Ala Ser Arg Ser Ala Cys Arg Trp Ala Leu Leu Leu Leu 
1               5                   10                  15      


Ala Val Leu Trp Pro Gln Gln Arg Ala Ala Gly Ser Gly Ile Phe Gln 
            20                  25                  30          


Leu Arg Leu Gln Glu Phe Val Asn Gln Arg Gly Met Leu Ala Asn Gly 
        35                  40                  45              


Gln Ser Cys Glu Pro Gly Cys Arg Thr Phe Phe Arg Ile Cys Leu Lys 
    50                  55                  60                  


His Phe Gln Ala Thr Phe Ser Glu Gly Pro Cys Thr Phe Gly Asn Val 
65                  70                  75                  80  


Ser Thr Pro Val Leu Gly Thr Asn Ser Phe Val Val Arg Asp Lys Asn 
                85                  90                  95      


Ser Gly Ser Gly Arg Asn Pro Leu Gln Leu Pro Phe Asn Phe Thr Trp 
            100                 105                 110         


Pro Gly Thr Phe Ser Leu Asn Ile Gln Ala Trp His Thr Pro Gly Asp 
        115                 120                 125             


Asp Leu Arg Pro Glu Thr Ser Pro Gly Asn Ser Leu Ile Ser Gln Ile 
    130                 135                 140                 


Ile Ile Gln Gly Ser Leu Ala Val Gly Lys Ile Trp Arg Thr Asp Glu 
145                 150                 155                 160 


Gln Asn Asp Thr Leu Thr Arg Leu Ser Tyr Ser Tyr Arg Val Ile Cys 
                165                 170                 175     


Ser Asp Asn Tyr Tyr Gly Glu Ser Cys Ser Arg Leu Cys Lys Lys Arg 
            180                 185                 190         


Asp Asp His Phe Gly His Tyr Glu Cys Gln Pro Asp Gly Ser Leu Ser 
        195                 200                 205             


Cys Leu Pro Gly Trp Thr Gly Lys Tyr Cys Asp Gln Pro Ile Cys Leu 
    210                 215                 220                 


Ser Gly Cys His Glu Gln Asn Gly Tyr Cys Ser Lys Pro Asp Glu Cys 
225                 230                 235                 240 


Ile Cys Arg Pro Gly Trp Gln Gly Arg Leu Cys Asn Glu Cys Ile Pro 
                245                 250                 255     


His Asn Gly Cys Arg His Gly Thr Cys Ser Ile Pro Trp Gln Cys Ala 
            260                 265                 270         


Cys Asp Glu Gly Trp Gly Gly Leu Phe Cys Asp Gln Asp Leu Asn Tyr 
        275                 280                 285             


Cys Thr His His Ser Pro Cys Lys Asn Gly Ser Thr Cys Ser Asn Ser 
    290                 295                 300                 


Gly Pro Lys Gly Tyr Thr Cys Thr Cys Leu Pro Gly Tyr Thr Gly Glu 
305                 310                 315                 320 


His Cys Glu Leu Gly Leu Ser Lys Cys Ala Ser Asn Pro Cys Arg Asn 
                325                 330                 335     


Gly Gly Ser Cys Lys Asp Gln Glu Asn Ser Tyr His Cys Leu Cys Pro 
            340                 345                 350         


Pro Gly Tyr Tyr Gly Gln His Cys Glu His Ser Thr Leu Thr Cys Ala 
        355                 360                 365             


Asp Ser Pro Cys Phe Asn Gly Gly Ser Cys Arg Glu Arg Asn Gln Gly 
    370                 375                 380                 


Ser Ser Tyr Ala Cys Glu Cys Pro Pro Asn Phe Thr Gly Ser Asn Cys 
385                 390                 395                 400 


Glu Lys Lys Val Asp Arg Cys Thr Ser Asn Pro Cys Ala Asn Gly Gly 
                405                 410                 415     


Gln Cys Gln Asn Arg Gly Pro Ser Arg Thr Cys Arg Cys Arg Pro Gly 
            420                 425                 430         


Phe Thr Gly Thr His Cys Glu Leu His Ile Ser Asp Cys Ala Arg Ser 
        435                 440                 445             


Pro Cys Ala His Gly Gly Thr Cys His Asp Leu Glu Asn Gly Pro Val 
    450                 455                 460                 


Cys Thr Cys Pro Ala Gly Phe Ser Gly Arg Arg Cys Glu Val Arg Ile 
465                 470                 475                 480 


Thr His Asp Ala Cys Ala Ser Gly Pro Cys Phe Asn Gly Ala Thr Cys 
                485                 490                 495     


Tyr Thr Gly Leu Ser Pro Asn Asn Phe Val Cys Asn Cys Pro Tyr Gly 
            500                 505                 510         


Phe Val Gly Ser Arg Cys Glu Phe Pro Val Gly Leu Pro Pro Ser Phe 
        515                 520                 525             


Pro Trp Val Ala 
    530         


<210> 39
<211> 154
<212> PRT
<213> Mus sp.

<400> 39
Val Ser Leu Gly Val Gly Leu Val Val Leu Leu Val Leu Leu Val Met 
1               5                   10                  15      


Val Val Val Ala Val Arg Gln Leu Arg Leu Arg Arg Pro Asp Asp Glu 
            20                  25                  30          


Ser Arg Glu Ala Met Asn Asn Leu Ser Asp Phe Gln Lys Asp Asn Leu 
        35                  40                  45              


Ile Pro Ala Ala Gln Leu Lys Asn Thr Asn Gln Lys Lys Glu Leu Glu 
    50                  55                  60                  


Val Asp Cys Gly Leu Asp Lys Ser Asn Cys Gly Lys Leu Gln Asn His 
65                  70                  75                  80  


Thr Leu Asp Tyr Asn Leu Ala Pro Gly Leu Leu Gly Arg Gly Gly Met 
                85                  90                  95      


Pro Gly Lys Tyr Pro His Ser Asp Lys Ser Leu Gly Glu Lys Val Pro 
            100                 105                 110         


Leu Arg Leu His Ser Glu Lys Pro Glu Cys Arg Ile Ser Ala Ile Cys 
        115                 120                 125             


Ser Pro Arg Asp Ser Met Tyr Gln Ser Val Cys Leu Ile Ser Glu Glu 
    130                 135                 140                 


Arg Asn Glu Cys Val Ile Ala Thr Glu Val 
145                 150                 


<210> 40
<211> 236
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 40
Met Val Ser Lys Gly Glu Glu Asp Asn Met Ala Ile Ile Lys Glu Phe 
1               5                   10                  15      


Met Arg Phe Lys Val His Met Glu Gly Ser Val Asn Gly His Glu Phe 
            20                  25                  30          


Glu Ile Glu Gly Glu Gly Glu Gly Arg Pro Tyr Glu Gly Thr Gln Thr 
        35                  40                  45              


Ala Lys Leu Lys Val Thr Lys Gly Gly Pro Leu Pro Phe Ala Trp Asp 
    50                  55                  60                  


Ile Leu Ser Pro Gln Phe Met Tyr Gly Ser Lys Ala Tyr Val Lys His 
65                  70                  75                  80  


Pro Ala Asp Ile Pro Asp Tyr Leu Lys Leu Ser Phe Pro Glu Gly Phe 
                85                  90                  95      


Lys Trp Glu Arg Val Met Asn Phe Glu Asp Gly Gly Val Val Thr Val 
            100                 105                 110         


Thr Gln Asp Ser Ser Leu Gln Asp Gly Glu Phe Ile Tyr Lys Val Lys 
        115                 120                 125             


Leu Arg Gly Thr Asn Phe Pro Ser Asp Gly Pro Val Met Gln Lys Lys 
    130                 135                 140                 


Thr Met Gly Trp Glu Ala Ser Ser Glu Arg Met Tyr Pro Glu Asp Gly 
145                 150                 155                 160 


Ala Leu Lys Gly Glu Ile Lys Gln Arg Leu Lys Leu Lys Asp Gly Gly 
                165                 170                 175     


His Tyr Asp Ala Glu Val Lys Thr Thr Tyr Lys Ala Lys Lys Pro Val 
            180                 185                 190         


Gln Leu Pro Gly Ala Tyr Asn Val Asn Ile Lys Leu Asp Ile Thr Ser 
        195                 200                 205             


His Asn Glu Asp Tyr Thr Ile Val Glu Gln Tyr Glu Arg Ala Glu Gly 
    210                 215                 220                 


Arg His Ser Thr Gly Gly Met Asp Glu Leu Tyr Lys 
225                 230                 235     


<210> 41
<211> 25
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      amino acid sequence encoding SS for cis-inhibitors

<400> 41
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Gly Gly Gly Gly 
            20                  25  


<210> 42
<211> 274
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 42
Gly Gly Gly Gly Ser Thr Gly Asp Gly Gly Gly Gly Glu Val Gln Leu 
1               5                   10                  15      


Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu 
            20                  25                  30          


Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr Trp Ile His Trp 
        35                  40                  45              


Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Asn 
    50                  55                  60                  


Pro Pro Asn Arg Ser Asn Gln Tyr Ala Asp Ser Val Lys Gly Arg Phe 
65                  70                  75                  80  


Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn 
                85                  90                  95      


Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Gly Ser 
            100                 105                 110         


Gly Phe Arg Trp Val Met Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr 
        115                 120                 125             


Val Ser Ser Gly Gly Ser Ser Arg Ser Ser Ser Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu 
145                 150                 155                 160 


Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln 
                165                 170                 175     


Asp Val Ser Thr Ala Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala 
            180                 185                 190         


Pro Lys Leu Leu Ile Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro 
        195                 200                 205             


Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile 
    210                 215                 220                 


Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Phe 
225                 230                 235                 240 


Tyr Thr Thr Pro Ser Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
                245                 250                 255     


Gly Gly Gly Ser Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Gly Gly 
            260                 265                 270         


Gly Ser 
        


<210> 43
<211> 1225
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 43
Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Gln 
            20                  25                  30          


Val Gln Leu Val Glu Ser Gly Gly Asn Leu Val Gln Pro Gly Gly Ser 
        35                  40                  45              


Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Gly Ser Phe Ser 
    50                  55                  60                  


Met Ser Trp Val Arg Gln Ala Pro Gly Gly Gly Leu Glu Trp Val Ala 
65                  70                  75                  80  


Gly Leu Ser Ala Arg Ser Ser Leu Thr His Tyr Ala Asp Ser Val Lys 
                85                  90                  95      


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Val Tyr Leu 
            100                 105                 110         


Gln Met Asn Ser Leu Arg Val Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
        115                 120                 125             


Arg Arg Ser Tyr Asp Ser Ser Gly Tyr Ala Gly His Phe Tyr Ser Tyr 
    130                 135                 140                 


Met Asp Val Trp Gly Gln Gly Thr Leu Val Thr Val Ser Gly Gly Gly 
145                 150                 155                 160 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser Val Leu Thr 
                165                 170                 175     


Gln Pro Ser Ser Val Ser Ala Ala Pro Gly Gln Lys Val Thr Ile Ser 
            180                 185                 190         


Cys Ser Gly Ser Thr Ser Asn Ile Gly Asn Asn Tyr Val Ser Trp Tyr 
        195                 200                 205             


Gln Gln His Pro Gly Lys Ala Pro Lys Leu Met Ile Tyr Asp Val Ser 
    210                 215                 220                 


Lys Arg Pro Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Lys Ser Gly 
225                 230                 235                 240 


Asn Ser Ala Ser Leu Asp Ile Ser Gly Leu Gln Ser Glu Asp Glu Ala 
                245                 250                 255     


Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu Ser Glu Phe Leu Phe 
            260                 265                 270         


Gly Thr Gly Thr Lys Leu Thr Val Leu Gly Gly Gly Gly Ser Met Ala 
        275                 280                 285             


Asp Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
    290                 295                 300                 


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Ile Ser Met Ala 
305                 310                 315                 320 


Ala Met Ser Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
                325                 330                 335     


Ala Gly Ile Ser Arg Ser Ala Gly Ser Ala Val His Ala Asp Ser Val 
            340                 345                 350         


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Thr Lys Asn Thr Leu Tyr 
        355                 360                 365             


Leu Gln Met Asn Ser Leu Lys Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
    370                 375                 380                 


Ala Val Arg Thr Ser Gly Phe Phe Gly Ser Ile Pro Arg Thr Gly Thr 
385                 390                 395                 400 


Ala Phe Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Gly Gly 
                405                 410                 415     


Gly Gly Ser Thr Gly Asp Gly Gly Gly Gly Glu Val Gln Leu Val Glu 
            420                 425                 430         


Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys 
        435                 440                 445             


Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr Trp Ile His Trp Val Arg 
    450                 455                 460                 


Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Asn Pro Pro 
465                 470                 475                 480 


Asn Arg Ser Asn Gln Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile 
                485                 490                 495     


Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Ser Leu 
            500                 505                 510         


Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Gly Ser Gly Phe 
        515                 520                 525             


Arg Trp Val Met Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
    530                 535                 540                 


Ser Gly Gly Ser Ser Arg Ser Ser Ser Ser Gly Gly Gly Gly Ser Gly 
545                 550                 555                 560 


Gly Gly Gly Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala 
                565                 570                 575     


Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val 
            580                 585                 590         


Ser Thr Ala Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys 
        595                 600                 605             


Leu Leu Ile Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro Ser Arg 
    610                 615                 620                 


Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser 
625                 630                 635                 640 


Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Phe Tyr Thr 
                645                 650                 655     


Thr Pro Ser Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Gly Gly 
            660                 665                 670         


Gly Ser Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Gly Gly Gly Ser 
        675                 680                 685             


Ile Leu Asp Tyr Ser Phe Thr Gly Gly Ala Gly Arg Asp Ile Pro Pro 
    690                 695                 700                 


Pro Gln Ile Glu Glu Ala Cys Glu Leu Pro Glu Cys Gln Val Asp Ala 
705                 710                 715                 720 


Gly Asn Lys Val Cys Asn Leu Gln Cys Asn Asn His Ala Cys Gly Trp 
                725                 730                 735     


Asp Gly Gly Asp Cys Ser Leu Asn Phe Asn Asp Pro Trp Lys Asn Cys 
            740                 745                 750         


Thr Gln Ser Leu Gln Cys Trp Lys Tyr Phe Ser Asp Gly His Cys Asp 
        755                 760                 765             


Ser Gln Cys Asn Ser Ala Gly Cys Leu Phe Asp Gly Phe Asp Cys Gln 
    770                 775                 780                 


Leu Thr Glu Gly Gln Cys Asn Pro Leu Tyr Asp Gln Tyr Cys Lys Asp 
785                 790                 795                 800 


His Phe Ser Asp Gly His Cys Asp Gln Gly Cys Asn Ser Ala Glu Cys 
                805                 810                 815     


Glu Trp Asp Gly Leu Asp Cys Ala Glu His Val Pro Glu Arg Leu Ala 
            820                 825                 830         


Ala Gly Thr Leu Val Leu Val Val Leu Leu Pro Pro Asp Gln Leu Arg 
        835                 840                 845             


Asn Asn Ser Phe His Phe Leu Arg Glu Leu Ser His Val Leu His Thr 
    850                 855                 860                 


Asn Val Val Phe Lys Arg Asp Ala Gln Gly Gln Gln Met Ile Phe Pro 
865                 870                 875                 880 


Tyr Tyr Gly His Glu Glu Glu Leu Arg Lys His Pro Ile Lys Arg Ser 
                885                 890                 895     


Thr Val Gly Trp Ala Thr Ser Ser Leu Leu Pro Gly Thr Ser Gly Gly 
            900                 905                 910         


Arg Gln Arg Arg Glu Leu Asp Pro Met Asp Ile Arg Gly Ser Ile Val 
        915                 920                 925             


Tyr Leu Glu Ile Asp Asn Arg Gln Cys Val Gln Ser Ser Ser Gln Cys 
    930                 935                 940                 


Phe Gln Ser Ala Thr Asp Val Ala Ala Phe Leu Gly Ala Leu Ala Ser 
945                 950                 955                 960 


Leu Gly Ser Leu Asn Ile Pro Tyr Lys Ile Glu Ala Val Lys Ser Glu 
                965                 970                 975     


Pro Val Glu Pro Pro Leu Pro Ser Gln Leu His Leu Met Tyr Val Ala 
            980                 985                 990         


Ala Ala Ala Phe Val Leu Leu Phe  Phe Val Gly Cys Gly  Val Leu Leu 
        995                 1000                 1005             


Ser Arg  Lys Arg Arg Arg Met  Lys Leu Leu Ser Ser  Ile Glu Gln 
    1010                 1015                 1020             


Ala Cys  Asp Ile Cys Arg Leu  Lys Lys Leu Lys Cys  Ser Lys Glu 
    1025                 1030                 1035             


Lys Pro  Lys Cys Ala Lys Cys  Leu Lys Asn Asn Trp  Glu Cys Arg 
    1040                 1045                 1050             


Tyr Ser  Pro Lys Thr Lys Arg  Ser Pro Leu Thr Arg  Ala His Leu 
    1055                 1060                 1065             


Thr Glu  Val Glu Ser Arg Leu  Glu Arg Leu Glu Gln  Leu Phe Leu 
    1070                 1075                 1080             


Leu Ile  Phe Pro Arg Glu Asp  Leu Asp Met Ile Leu  Lys Met Asp 
    1085                 1090                 1095             


Ser Leu  Gln Asp Ile Lys Ala  Leu Leu Thr Gly Leu  Phe Val Gln 
    1100                 1105                 1110             


Asp Asn  Val Asn Lys Asp Ala  Val Thr Asp Arg Leu  Ala Ser Val 
    1115                 1120                 1125             


Glu Thr  Asp Met Pro Leu Thr  Leu Arg Gln His Arg  Ile Ser Ala 
    1130                 1135                 1140             


Thr Ser  Ser Ser Glu Glu Ser  Ser Asn Lys Gly Gln  Arg Gln Leu 
    1145                 1150                 1155             


Thr Val  Ser Ala Ala Ala Gly  Gly Ser Gly Gly Ser  Gly Gly Ser 
    1160                 1165                 1170             


Asp Ala  Leu Asp Asp Phe Asp  Leu Asp Met Leu Gly  Ser Asp Ala 
    1175                 1180                 1185             


Leu Asp  Asp Phe Asp Leu Asp  Met Leu Gly Ser Asp  Ala Leu Asp 
    1190                 1195                 1200             


Asp Phe  Asp Leu Asp Met Leu  Gly Ser Asp Ala Leu  Asp Asp Phe 
    1205                 1210                 1215             


Asp Leu  Asp Met Leu Gly Ser  
    1220                 1225 


<210> 44
<211> 574
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 44
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Gly Gly Gly Gly Glu Val Gln Leu Val Glu Ser 
            20                  25                  30          


Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala 
        35                  40                  45              


Ala Ser Gly Phe Thr Phe Ser Ser Tyr Trp Ile His Trp Val Arg Gln 
    50                  55                  60                  


Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Asn Pro Pro Asn 
65                  70                  75                  80  


Arg Ser Asn Gln Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser 
                85                  90                  95      


Ala Asp Thr Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Ser Leu Arg 
            100                 105                 110         


Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Gly Ser Gly Phe Arg 
        115                 120                 125             


Trp Val Met Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
    130                 135                 140                 


Gly Gly Ser Ser Arg Ser Ser Ser Ser Gly Gly Gly Gly Ser Gly Gly 
145                 150                 155                 160 


Gly Gly Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser 
                165                 170                 175     


Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Ser 
            180                 185                 190         


Thr Ala Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu 
        195                 200                 205             


Leu Ile Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro Ser Arg Phe 
    210                 215                 220                 


Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu 
225                 230                 235                 240 


Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Phe Tyr Thr Thr 
                245                 250                 255     


Pro Ser Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Gly Gly Gly 
            260                 265                 270         


Ser Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Gly Gly Gly Ser Ala 
        275                 280                 285             


Val Gly Gln Asp Thr Gln Glu Val Ile Val Val Pro His Ser Leu Pro 
    290                 295                 300                 


Phe Lys Val Val Val Ile Ser Ala Ile Leu Ala Leu Val Val Leu Thr 
305                 310                 315                 320 


Ile Ile Ser Leu Ile Ile Leu Ile Met Leu Trp Gln Lys Lys Pro Arg 
                325                 330                 335     


Arg Thr Met Val Ser Lys Gly Glu Glu Asp Asn Met Ala Ile Ile Lys 
            340                 345                 350         


Glu Phe Met Arg Phe Lys Val His Met Glu Gly Ser Val Asn Gly His 
        355                 360                 365             


Glu Phe Glu Ile Glu Gly Glu Gly Glu Gly Arg Pro Tyr Glu Gly Thr 
    370                 375                 380                 


Gln Thr Ala Lys Leu Lys Val Thr Lys Gly Gly Pro Leu Pro Phe Ala 
385                 390                 395                 400 


Trp Asp Ile Leu Ser Pro Gln Phe Met Tyr Gly Ser Lys Ala Tyr Val 
                405                 410                 415     


Lys His Pro Ala Asp Ile Pro Asp Tyr Leu Lys Leu Ser Phe Pro Glu 
            420                 425                 430         


Gly Phe Lys Trp Glu Arg Val Met Asn Phe Glu Asp Gly Gly Val Val 
        435                 440                 445             


Thr Val Thr Gln Asp Ser Ser Leu Gln Asp Gly Glu Phe Ile Tyr Lys 
    450                 455                 460                 


Val Lys Leu Arg Gly Thr Asn Phe Pro Ser Asp Gly Pro Val Met Gln 
465                 470                 475                 480 


Lys Lys Thr Met Gly Trp Glu Ala Ser Ser Glu Arg Met Tyr Pro Glu 
                485                 490                 495     


Asp Gly Ala Leu Lys Gly Glu Ile Lys Gln Arg Leu Lys Leu Lys Asp 
            500                 505                 510         


Gly Gly His Tyr Asp Ala Glu Val Lys Thr Thr Tyr Lys Ala Lys Lys 
        515                 520                 525             


Pro Val Gln Leu Pro Gly Ala Tyr Asn Val Asn Ile Lys Leu Asp Ile 
    530                 535                 540                 


Thr Ser His Asn Glu Asp Tyr Thr Ile Val Glu Gln Tyr Glu Arg Ala 
545                 550                 555                 560 


Glu Gly Arg His Ser Thr Gly Gly Met Asp Glu Leu Tyr Lys 
                565                 570                 


<210> 45
<211> 1245
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 45
Met Gly Arg Arg Ser Ala Leu Ala Leu Ala Val Val Ser Ala Leu Leu 
1               5                   10                  15      


Cys Gln Val Trp Ser Ser Gly Val Phe Glu Leu Lys Leu Gln Glu Phe 
            20                  25                  30          


Val Asn Lys Lys Gly Leu Leu Gly Asn Arg Asn Cys Cys Arg Gly Gly 
        35                  40                  45              


Ser Gly Pro Pro Cys Ala Cys Arg Thr Phe Phe Arg Val Cys Leu Lys 
    50                  55                  60                  


His Tyr Gln Ala Ser Val Ser Pro Glu Pro Pro Cys Thr Tyr Gly Ser 
65                  70                  75                  80  


Ala Val Thr Ala Val Leu Gly Val Asp Ser Phe Ser Leu Pro Asp Gly 
                85                  90                  95      


Ala Gly Ile Asp Pro Ala Phe Ser Asn Pro Ile Arg Phe Pro Phe Gly 
            100                 105                 110         


Phe Thr Trp Pro Gly Thr Phe Ser Leu Ile Ile Glu Ala Leu His Thr 
        115                 120                 125             


Asp Ser Pro Asp Asp Leu Ala Thr Glu Asn Pro Glu Arg Leu Ile Ser 
    130                 135                 140                 


Arg Leu Thr Thr Gln Arg His Leu Thr Val Gly Glu Glu Trp Ser Gln 
145                 150                 155                 160 


Asp Leu His Ser Ser Gly Arg Thr Asp Leu Arg Tyr Ser Tyr Arg Phe 
                165                 170                 175     


Val Cys Asp Glu His Tyr Tyr Gly Glu Gly Cys Ser Val Phe Cys Arg 
            180                 185                 190         


Pro Arg Asp Asp Ala Phe Gly His Phe Thr Cys Gly Glu Arg Gly Glu 
        195                 200                 205             


Lys Met Cys Asp Pro Gly Trp Lys Gly Gln Tyr Cys Thr Asp Pro Ile 
    210                 215                 220                 


Cys Leu Pro Gly Cys Asp Asp Gln His Gly Tyr Cys Asp Lys Pro Gly 
225                 230                 235                 240 


Glu Cys Lys Cys Arg Val Gly Trp Gln Gly Arg Tyr Cys Asp Glu Cys 
                245                 250                 255     


Ile Arg Tyr Pro Gly Cys Leu His Gly Thr Cys Gln Gln Pro Trp Gln 
            260                 265                 270         


Cys Asn Cys Gln Glu Gly Trp Gly Gly Leu Phe Cys Asn Gln Asp Leu 
        275                 280                 285             


Asn Tyr Cys Thr His His Lys Pro Cys Arg Asn Gly Ala Thr Cys Thr 
    290                 295                 300                 


Asn Thr Gly Gln Gly Ser Tyr Thr Cys Ser Cys Arg Pro Gly Tyr Thr 
305                 310                 315                 320 


Gly Ala Asn Cys Glu Leu Glu Val Asp Glu Cys Ala Pro Ser Pro Cys 
                325                 330                 335     


Arg Asn Gly Gly Ser Cys Thr Asp Leu Glu Asp Ser Tyr Ser Cys Thr 
            340                 345                 350         


Cys Pro Pro Gly Phe Tyr Gly Lys Val Cys Glu Leu Ser Ala Met Thr 
        355                 360                 365             


Cys Ala Asp Gly Pro Cys Phe Asn Gly Gly Arg Cys Ser Asp Asn Pro 
    370                 375                 380                 


Asp Gly Gly Tyr Thr Cys His Cys Pro Ala Gly Phe Ser Gly Phe Asn 
385                 390                 395                 400 


Cys Glu Lys Lys Ile Asp Leu Cys Ser Ser Ser Pro Cys Ser Asn Gly 
                405                 410                 415     


Ala Lys Cys Val Asp Leu Gly Asn Ser Tyr Leu Cys Arg Cys Gln Thr 
            420                 425                 430         


Gly Phe Ser Gly Arg Tyr Cys Glu Asp Asn Val Asp Asp Cys Ala Ser 
        435                 440                 445             


Ser Pro Cys Ala Asn Gly Gly Thr Cys Arg Asp Ser Val Asn Asp Phe 
    450                 455                 460                 


Ser Cys Thr Cys Pro Pro Gly Tyr Thr Gly Arg Asn Cys Ser Ala Pro 
465                 470                 475                 480 


Val Ser Arg Cys Glu His Ala Pro Cys His Asn Gly Ala Thr Cys His 
                485                 490                 495     


Gln Arg Gly Gln Arg Tyr Met Cys Glu Cys Ala Gln Gly Tyr Gly Gly 
            500                 505                 510         


Ala Asn Cys Gln Phe Leu Leu Pro Glu Pro Pro Pro Asp Leu Ile Val 
        515                 520                 525             


Ala Ala Gln Gly Gly Ser Phe Pro Trp Ser Arg Ala Asp Met Ala Ser 
    530                 535                 540                 


Met Thr Gly Gly Gln Gln Met Gly Ser Thr Glu Asp Val Val Cys Cys 
545                 550                 555                 560 


His Ser Ile Tyr Gly Lys Lys Lys Gly Asp Ile Asp Thr Tyr Arg Tyr 
                565                 570                 575     


Ile Gly Ser Ser Gly Thr Gly Cys Val Val Ile Val Gly Arg Ile Val 
            580                 585                 590         


Leu Ser Gly Ser Gly Thr Ser Ala Pro Ile Thr Ala Tyr Ala Gln Gln 
        595                 600                 605             


Thr Arg Gly Leu Leu Gly Cys Ile Ile Thr Ser Leu Thr Gly Arg Asp 
    610                 615                 620                 


Lys Asn Gln Val Glu Gly Glu Val Gln Ile Val Ser Thr Ala Thr Gln 
625                 630                 635                 640 


Thr Phe Leu Ala Thr Cys Ile Asn Gly Val Cys Trp Ala Val Tyr His 
                645                 650                 655     


Gly Ala Gly Thr Arg Thr Ile Ala Ser Pro Lys Gly Pro Val Ile Gln 
            660                 665                 670         


Met Tyr Thr Asn Val Asp Gln Asp Leu Val Gly Trp Pro Ala Pro Gln 
        675                 680                 685             


Gly Ser Arg Ser Leu Thr Pro Cys Thr Cys Gly Ser Ser Asp Leu Tyr 
    690                 695                 700                 


Leu Val Thr Arg His Ala Asp Val Ile Pro Val Arg Arg Arg Gly Asp 
705                 710                 715                 720 


Ser Arg Gly Ser Leu Leu Ser Pro Arg Pro Ile Ser Tyr Leu Lys Gly 
                725                 730                 735     


Ser Ser Gly Gly Pro Leu Leu Cys Pro Ala Gly His Ala Val Gly Leu 
            740                 745                 750         


Phe Arg Ala Ala Val Cys Thr Arg Gly Val Ala Lys Ala Val Asp Phe 
        755                 760                 765             


Ile Pro Val Glu Asn Leu Glu Thr Thr Met Arg Ser Pro Val Phe Thr 
    770                 775                 780                 


Asp Asn Ser Ser Pro Pro Ala Val Thr Leu Thr His Pro Ile Thr Lys 
785                 790                 795                 800 


Ile Asp Arg Glu Val Leu Tyr Gln Glu Phe Asp Glu Met Glu Glu Cys 
                805                 810                 815     


Ser Gln His Tyr Pro Tyr Asp Val Pro Asp Tyr Ala Gly Ala Ser Ala 
            820                 825                 830         


Val Ala Val Cys Ala Gly Val Val Leu Val Leu Leu Leu Leu Leu Gly 
        835                 840                 845             


Cys Ala Ala Val Val Val Cys Val Arg Leu Lys Leu Gln Lys His Gln 
    850                 855                 860                 


Pro Pro Pro Asp Pro Cys Gly Gly Glu Thr Glu Thr Met Asn Asn Leu 
865                 870                 875                 880 


Ala Asn Cys Gln Arg Glu Lys Asp Val Ser Val Ser Ile Ile Gly Ala 
                885                 890                 895     


Thr Gln Ile Lys Asn Thr Asn Lys Lys Ala Asp Phe His Gly Asp His 
            900                 905                 910         


Gly Ala Asp Lys Ser Ser Phe Lys Ala Arg Tyr Pro Thr Val Asp Tyr 
        915                 920                 925             


Asn Leu Ile Arg Asp Leu Lys Gly Asp Glu Ala Thr Val Arg Asp Ala 
    930                 935                 940                 


His Ser Lys Arg Asp Thr Lys Cys Gln Ser Gln Gly Ser Val Gly Glu 
945                 950                 955                 960 


Glu Lys Ser Thr Ser Thr Leu Arg Gly Gly Glu Val Pro Asp Arg Lys 
                965                 970                 975     


Arg Pro Glu Ser Val Tyr Ser Thr Ser Lys Asp Thr Lys Tyr Gln Ser 
            980                 985                 990         


Val Tyr Val Leu Ser Ala Glu Lys  Asp Glu Cys Val Ile  Ala Thr Glu 
        995                 1000                 1005             


Val Val  Ser Lys Gly Glu Glu  Asp Asn Met Ala Ile  Ile Lys Glu 
    1010                 1015                 1020             


Phe Met  Arg Phe Lys Val His  Met Glu Gly Ser Val  Asn Gly His 
    1025                 1030                 1035             


Glu Phe  Glu Ile Glu Gly Glu  Gly Glu Gly Arg Pro  Tyr Glu Gly 
    1040                 1045                 1050             


Thr Gln  Thr Ala Lys Leu Lys  Val Thr Lys Gly Gly  Pro Leu Pro 
    1055                 1060                 1065             


Phe Ala  Trp Asp Ile Leu Ser  Pro Gln Phe Met Tyr  Gly Ser Lys 
    1070                 1075                 1080             


Ala Tyr  Val Lys His Pro Ala  Asp Ile Pro Asp Tyr  Leu Lys Leu 
    1085                 1090                 1095             


Ser Phe  Pro Glu Gly Phe Lys  Trp Glu Arg Val Met  Asn Phe Glu 
    1100                 1105                 1110             


Asp Gly  Gly Val Val Thr Val  Thr Gln Asp Ser Ser  Leu Gln Asp 
    1115                 1120                 1125             


Gly Glu  Phe Ile Tyr Lys Val  Lys Leu Arg Gly Thr  Asn Phe Pro 
    1130                 1135                 1140             


Ser Asp  Gly Pro Val Met Gln  Lys Lys Thr Met Gly  Trp Glu Ala 
    1145                 1150                 1155             


Ser Ser  Glu Arg Met Tyr Pro  Glu Asp Gly Ala Leu  Lys Gly Glu 
    1160                 1165                 1170             


Ile Lys  Gln Arg Leu Lys Leu  Lys Asp Gly Gly His  Tyr Asp Ala 
    1175                 1180                 1185             


Glu Val  Lys Thr Thr Tyr Lys  Ala Lys Lys Pro Val  Gln Leu Pro 
    1190                 1195                 1200             


Gly Ala  Tyr Asn Val Asn Ile  Lys Leu Asp Ile Thr  Ser His Asn 
    1205                 1210                 1215             


Glu Asp  Tyr Thr Ile Val Glu  Gln Tyr Glu Arg Ala  Glu Gly Arg 
    1220                 1225                 1230             


His Ser  Thr Gly Gly Met Asp  Glu Leu Tyr Lys Ser  
    1235                 1240                 1245 


<210> 46
<211> 312
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 46
Pro Pro Pro Gln Ile Glu Glu Ala Cys Glu Leu Pro Glu Cys Gln Val 
1               5                   10                  15      


Asp Ala Gly Asn Lys Val Cys Asn Leu Gln Cys Asn Asn His Ala Cys 
            20                  25                  30          


Gly Trp Asp Gly Gly Asp Cys Ser Leu Asn Phe Asn Asp Pro Trp Lys 
        35                  40                  45              


Asn Cys Thr Gln Ser Leu Gln Cys Trp Lys Tyr Phe Ser Asp Gly His 
    50                  55                  60                  


Cys Asp Ser Gln Cys Asn Ser Ala Gly Cys Leu Phe Asp Gly Phe Asp 
65                  70                  75                  80  


Cys Gln Leu Thr Glu Gly Gln Cys Asn Pro Leu Tyr Asp Gln Tyr Cys 
                85                  90                  95      


Lys Asp His Phe Ser Asp Gly His Cys Asp Gln Gly Cys Asn Ser Ala 
            100                 105                 110         


Glu Cys Glu Trp Asp Gly Leu Asp Cys Ala Glu His Val Pro Glu Arg 
        115                 120                 125             


Leu Ala Ala Gly Thr Leu Val Leu Val Val Leu Leu Pro Pro Asp Gln 
    130                 135                 140                 


Leu Arg Asn Asn Ser Phe His Phe Leu Arg Glu Leu Ser His Val Leu 
145                 150                 155                 160 


His Thr Asn Val Val Phe Lys Arg Asp Ala Gln Gly Gln Gln Met Ile 
                165                 170                 175     


Phe Pro Tyr Tyr Gly His Glu Glu Glu Leu Arg Lys His Pro Ile Lys 
            180                 185                 190         


Arg Ser Thr Val Gly Trp Ala Thr Ser Ser Leu Leu Pro Gly Thr Ser 
        195                 200                 205             


Gly Gly Arg Gln Arg Arg Glu Leu Asp Pro Met Asp Ile Arg Gly Ser 
    210                 215                 220                 


Ile Val Tyr Leu Glu Ile Asp Asn Arg Gln Cys Val Gln Ser Ser Ser 
225                 230                 235                 240 


Gln Cys Phe Gln Ser Ala Thr Asp Val Ala Ala Phe Leu Gly Ala Leu 
                245                 250                 255     


Ala Ser Leu Gly Ser Leu Asn Ile Pro Tyr Lys Ile Glu Ala Val Lys 
            260                 265                 270         


Ser Glu Pro Val Glu Pro Pro Leu Pro Ser Gln Leu His Leu Met Tyr 
        275                 280                 285             


Val Ala Ala Ala Ala Phe Val Leu Leu Phe Phe Val Gly Cys Gly Val 
    290                 295                 300                 


Leu Leu Ser Arg Lys Arg Arg Arg 
305                 310         


<210> 47
<211> 289
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 47
Pro Pro Ser Thr Pro Pro Ala Thr Cys Leu Ser Gln Tyr Cys Ala Asp 
1               5                   10                  15      


Lys Ala Arg Asp Gly Val Cys Asp Glu Ala Cys Asn Ser His Ala Cys 
            20                  25                  30          


Gln Trp Asp Gly Gly Asp Cys Ser Leu Thr Met Glu Asn Pro Trp Ala 
        35                  40                  45              


Asn Cys Ser Ser Pro Leu Pro Cys Trp Asp Tyr Ile Asn Asn Gln Cys 
    50                  55                  60                  


Asp Glu Leu Cys Asn Thr Val Glu Cys Leu Phe Asp Asn Phe Glu Cys 
65                  70                  75                  80  


Gln Gly Asn Ser Lys Thr Cys Lys Tyr Asp Lys Tyr Cys Ala Asp His 
                85                  90                  95      


Phe Lys Asp Asn His Cys Asp Gln Gly Cys Asn Ser Glu Glu Cys Gly 
            100                 105                 110         


Trp Asp Gly Leu Asp Cys Ala Ala Asp Gln Pro Glu Asn Leu Ala Glu 
        115                 120                 125             


Gly Thr Leu Val Ile Val Val Leu Met Pro Pro Glu Gln Leu Leu Gln 
    130                 135                 140                 


Asp Ala Arg Ser Phe Leu Arg Ala Leu Gly Thr Leu Leu His Thr Asn 
145                 150                 155                 160 


Leu Arg Ile Lys Arg Asp Ser Gln Gly Glu Leu Met Val Tyr Pro Tyr 
                165                 170                 175     


Tyr Gly Glu Lys Ser Ala Ala Met Lys Lys Gln Arg Met Thr Arg Arg 
            180                 185                 190         


Ser Leu Pro Gly Glu Gln Glu Gln Glu Val Ala Gly Ser Lys Val Phe 
        195                 200                 205             


Leu Glu Ile Asp Asn Arg Gln Cys Val Gln Asp Ser Asp His Cys Phe 
    210                 215                 220                 


Lys Asn Thr Asp Ala Ala Ala Ala Leu Leu Ala Ser His Ala Ile Gln 
225                 230                 235                 240 


Gly Thr Leu Ser Tyr Pro Leu Val Ser Val Val Ser Glu Ser Leu Thr 
                245                 250                 255     


Pro Glu Arg Thr Gln Leu Leu Tyr Leu Leu Ala Val Ala Val Val Ile 
            260                 265                 270         


Ile Leu Phe Ile Ile Leu Leu Gly Val Ile Met Ala Lys Arg Lys Arg 
        275                 280                 285             


Lys 
    


<210> 48
<211> 244
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 48
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Trp Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Asn Pro Pro Asn Arg Ser Asn Gln Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Ser Gly Phe Arg Trp Val Met Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Gly Gly Ser Ser Arg Ser Ser Ser Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Asp Ile Gln Met Thr Gln Ser 
    130                 135                 140                 


Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys 
145                 150                 155                 160 


Arg Ala Ser Gln Asp Val Ser Thr Ala Val Ala Trp Tyr Gln Gln Lys 
                165                 170                 175     


Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ser Ala Ser Phe Leu Tyr 
            180                 185                 190         


Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 
        195                 200                 205             


Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr 
    210                 215                 220                 


Cys Gln Gln Phe Tyr Thr Thr Pro Ser Thr Phe Gly Gln Gly Thr Lys 
225                 230                 235                 240 


Val Glu Ile Lys 
                


<210> 49
<211> 247
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 49
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Tyr Pro Tyr Ser Gly Ala Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg His Ser Gly Tyr Tyr Arg Ile Ser Ser Ala Met Asp Val Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ala Gly Gly Ser Ser Arg Ser 
        115                 120                 125             


Ser Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Asp Ile Gln Met 
    130                 135                 140                 


Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr 
145                 150                 155                 160 


Ile Thr Cys Arg Ala Ser Gln Asn Ile Lys Arg Phe Leu Ala Trp Tyr 
                165                 170                 175     


Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Gly Ala Ser 
            180                 185                 190         


Thr Arg Glu Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly 
        195                 200                 205             


Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala 
    210                 215                 220                 


Thr Tyr Tyr Cys Gln Gln Tyr Tyr Arg Ser Pro His Thr Phe Gly Gln 
225                 230                 235                 240 


Gly Thr Lys Val Glu Ile Lys 
                245         


<210> 50
<211> 1674
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 50
atgaagttgc tgagcagcat agagcaagca tgtgatatct gccggttgaa gaagctgaag       60

tgtagcaagg agaagcccaa gtgcgccaag tgtctcaaga ataattggga gtgtaggtat      120

agccccaaga ccaagcgaag cccgcttacg agagcacacc ttaccgaggt cgagagccgc      180

ctggaaagac tcgaacaact ttttcttctg attttcccca gggaggacct ggacatgatc      240

ctgaagatgg acagcctcca ggacatcaaa gcccttctta ccgggctgtt cgtgcaggac      300

aacgtcaaca aggatgcggt gaccgacaga ttggcgagcg tggagacgga catgcccttg      360

accctcagac aacataggat cagcgcgaca agctcatctg aagaatctag caataaggga      420

cagcgacagc tgaccgttag tggggcgtct gcaggcatgg ccagcatgac tggtggacag      480

caaatggggt cgacggagga cgtggtgtgc tgccactcaa tctacggcaa gaagaagggt      540

gatatcgaca cctaccgata cataggctct tccgggacag gctgcgtggt catagtgggc      600

aggatcgtct tgtccggatc cggcactagt gcgcccatca cggcgtacgc ccagcagacg      660

agaggcctcc tagggtgtat aatcaccagc ctgactggcc gggacaaaaa ccaagtggag      720

ggtgaggtcc agatcgtgtc aactgctacc caaaccttcc tggcaacgtg catcaatggg      780

gtatgctggg cagtctacca cggggccgga acgaggacca tcgcatcacc caagggtcct      840

gtcatccaga tgtataccaa tgtggaccaa gaccttgtgg gctggcccgc tcctcaaggt      900

tcccgctcat tgacaccctg tacctgcggc tcctcggacc tttacctggt cacgaggcac      960

gccgatgtca ttcccgtgcg ccggcgaggt gatagcaggg gtagcctgct ttcgccccgg     1020

cccatttcct acttgaaagg ctcctcgggg ggtccgctgt tgtgccccgc gggacacgcc     1080

gtgggcctat tcagggccgc ggtgtgcacc cgtggagtgg ctaaagcggt ggactttatc     1140

cctgtggaga acctagagac aaccatgaga tccccggtgt tcacggacaa ctcctctcca     1200

ccagcagtca ccctgacgca cccaatcacc aaaatcgata gggaggttct ctaccaggag     1260

ttcgatgaga tggaagagtg ctctcagcac tatccctacg atgtgcccga ttacgctggc     1320

gcgtctgcat gcgccaactt taatcaaagt ggaaacatcg cggacagctc actcagcttt     1380

accttcacca atagcagtaa cgggccgaac ctcataacca cccagaccaa cagccaggcc     1440

ttgagccagc cgatcgcctc atctaacgtg catgataact ttatgaacaa cgagatcacc     1500

gcgagtaaga tagacgacgg gaacaacagc aagcccctta gcccaggttg gacggaccag     1560

accgcctaca acgctttcgg cattacgacc ggcatgttca acaccacgac catggacgat     1620

gtgtacaact acctgttcga tgacgaagac acaccgccaa accccaaaaa agaa           1674


<210> 51
<211> 1518
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 51
atgaagttgc tgagcagcat agagcaagca tgtgatatct gccggttgaa gaagctgaag       60

tgtagcaagg agaagcccaa gtgcgccaag tgtctcaaga ataattggga gtgtaggtat      120

agccccaaga ccaagcgaag cccgcttacg agagcacacc ttaccgaggt cgagagccgc      180

ctggaaagac tcgaacaact ttttcttctg attttcccca gggaggacct ggacatgatc      240

ctgaagatgg acagcctcca ggacatcaaa gcccttctta ccgggctgtt cgtgcaggac      300

aacgtcaaca aggatgcggt gaccgacaga ttggcgagcg tggagacgga catgcccttg      360

accctcagac aacataggat cagcgcgaca agctcatctg aagaatctag caataaggga      420

cagcgacagc tgaccgttag tggggcgtct gcaggcatgg ccagcatgac tggtggacag      480

caaatggggt cgacggagga cgtggtgtgc tgccactcaa tctacggcaa gaagaagggt      540

gatatcgaca cctaccgata cataggctct tccgggacag gctgcgtggt catagtgggc      600

aggatcgtct tgtccggatc cggcactagt gcgcccatca cggcgtacgc ccagcagacg      660

agaggcctcc tagggtgtat aatcaccagc ctgactggcc gggacaaaaa ccaagtggag      720

ggtgaggtcc agatcgtgtc aactgctacc caaaccttcc tggcaacgtg catcaatggg      780

gtatgctggg cagtctacca cggggccgga acgaggacca tcgcatcacc caagggtcct      840

gtcatccaga tgtataccaa tgtggaccaa gaccttgtgg gctggcccgc tcctcaaggt      900

tcccgctcat tgacaccctg tacctgcggc tcctcggacc tttacctggt cacgaggcac      960

gccgatgtca ttcccgtgcg ccggcgaggt gatagcaggg gtagcctgct ttcgccccgg     1020

cccatttcct acttgaaagg ctcctcgggg ggtccgctgt tgtgccccgc gggacacgcc     1080

gtgggcctat tcagggccgc ggtgtgcacc cgtggagtgg ctaaagcggt ggactttatc     1140

cctgtggaga acctagagac aaccatgaga tccccggtgt tcacggacaa ctcctctcca     1200

ccagcagtca ccctgacgca cccaatcacc aaaatcgata gggaggttct ctaccaggag     1260

ttcgatgaga tggaagagtg ctctcagcac tatccctacg atgtgcccga ttacgctggc     1320

gcgtcgtctg catgccccaa gaagaagagg aaggtgtcgc cagggatccg tcgacttgac     1380

gcgttgatat caacaagttt gtacaaaaaa gcaggctaca aagaggccag cggttccgga     1440

cgggctgacg cattggacga ttttgatctg gatatgctgg gaagtgacgc cctcgatgat     1500

tttgaccttg acatgctt                                                   1518


<210> 52
<211> 1596
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 52
atgaagttgc tgagcagcat agagcaagca tgtgatatct gccggttgaa gaagctgaag       60

tgtagcaagg agaagcccaa gtgcgccaag tgtctcaaga ataattggga gtgtaggtat      120

agccccaaga ccaagcgaag cccgcttacg agagcacacc ttaccgaggt cgagagccgc      180

ctggaaagac tcgaacaact ttttcttctg attttcccca gggaggacct ggacatgatc      240

ctgaagatgg acagcctcca ggacatcaaa gcccttctta ccgggctgtt cgtgcaggac      300

aacgtcaaca aggatgcggt gaccgacaga ttggcgagcg tggagacgga catgcccttg      360

accctcagac aacataggat cagcgcgaca agctcatctg aagaatctag caataaggga      420

cagcgacagc tgaccgttag tggggcgtct gcaggcatgg ccagcatgac tggtggacag      480

caaatggggt cgacggagga cgtggtgtgc tgccactcaa tctacggcaa gaagaagggt      540

gatatcgaca cctaccgata cataggctct tccgggacag gctgcgtggt catagtgggc      600

aggatcgtct tgtccggatc cggcactagt gcgcccatca cggcgtacgc ccagcagacg      660

agaggcctcc tagggtgtat aatcaccagc ctgactggcc gggacaaaaa ccaagtggag      720

ggtgaggtcc agatcgtgtc aactgctacc caaaccttcc tggcaacgtg catcaatggg      780

gtatgctggg cagtctacca cggggccgga acgaggacca tcgcatcacc caagggtcct      840

gtcatccaga tgtataccaa tgtggaccaa gaccttgtgg gctggcccgc tcctcaaggt      900

tcccgctcat tgacaccctg tacctgcggc tcctcggacc tttacctggt cacgaggcac      960

gccgatgtca ttcccgtgcg ccggcgaggt gatagcaggg gtagcctgct ttcgccccgg     1020

cccatttcct acttgaaagg ctcctcgggg ggtccgctgt tgtgccccgc gggacacgcc     1080

gtgggcctat tcagggccgc ggtgtgcacc cgtggagtgg ctaaagcggt ggactttatc     1140

cctgtggaga acctagagac aaccatgaga tccccggtgt tcacggacaa ctcctctcca     1200

ccagcagtca ccctgacgca cccaatcacc aaaatcgata gggaggttct ctaccaggag     1260

ttcgatgaga tggaagagtg ctctcagcac tatccctacg atgtgcccga ttacgctggc     1320

gcgtcgtctg catgccccaa gaagaagagg aaggtgtcgc cagggatccg tcgacttgac     1380

gcgttgatat caacaagttt gtacaaaaaa gcaggctaca aagaggccag cggttccgga     1440

cgggctgacg cattggacga ttttgatctg gatatgctgg gaagtgacgc cctcgatgat     1500

tttgaccttg acatgcttgg ttcggatgcc cttgatgact ttgacctcga catgctcggc     1560

agtgacgccc ttgatgattt cgacctggac atgctg                               1596


<210> 53
<211> 2427
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 53
atgaagttgc tgagcagcat agagcaagca tgtgatatct gccggttgaa gaagctgaag       60

tgtagcaagg agaagcccaa gtgcgccaag tgtctcaaga ataattggga gtgtaggtat      120

agccccaaga ccaagcgaag cccgcttacg agagcacacc ttaccgaggt cgagagccgc      180

ctggaaagac tcgaacaact ttttcttctg attttcccca gggaggacct ggacatgatc      240

ctgaagatgg acagcctcca ggacatcaaa gcccttctta ccgggctgtt cgtgcaggac      300

aacgtcaaca aggatgcggt gaccgacaga ttggcgagcg tggagacgga catgcccttg      360

accctcagac aacataggat cagcgcgaca agctcatctg aagaatctag caataaggga      420

cagcgacagc tgaccgttag tggggcgtct gcaggcatgg ccagcatgac tggtggacag      480

caaatggggt cgacggagga cgtggtgtgc tgccactcaa tctacggcaa gaagaagggt      540

gatatcgaca cctaccgata cataggctct tccgggacag gctgcgtggt catagtgggc      600

aggatcgtct tgtccggatc cggcactagt gcgcccatca cggcgtacgc ccagcagacg      660

agaggcctcc tagggtgtat aatcaccagc ctgactggcc gggacaaaaa ccaagtggag      720

ggtgaggtcc agatcgtgtc aactgctacc caaaccttcc tggcaacgtg catcaatggg      780

gtatgctggg cagtctacca cggggccgga acgaggacca tcgcatcacc caagggtcct      840

gtcatccaga tgtataccaa tgtggaccaa gaccttgtgg gctggcccgc tcctcaaggt      900

tcccgctcat tgacaccctg tacctgcggc tcctcggacc tttacctggt cacgaggcac      960

gccgatgtca ttcccgtgcg ccggcgaggt gatagcaggg gtagcctgct ttcgccccgg     1020

cccatttcct acttgaaagg ctcctcgggg ggtccgctgt tgtgccccgc gggacacgcc     1080

gtgggcctat tcagggccgc ggtgtgcacc cgtggagtgg ctaaagcggt ggactttatc     1140

cctgtggaga acctagagac aaccatgaga tccccggtgt tcacggacaa ctcctctcca     1200

ccagcagtca ccctgacgca cccaatcacc aaaatcgata gggaggttct ctaccaggag     1260

ttcgatgaga tggaagagtg ctctcagcac tatccctacg atgtgcccga ttacgctggc     1320

gcgtcgtctg catgccccaa gaagaagagg aaggtgtcgc cagggatccg tcgacttgac     1380

gcgttgatat caacaagttt gtacaaaaaa gcaggctaca aagaggccag cggttccgga     1440

cgggctgacg cattggacga ttttgatctg gatatgctgg gaagtgacgc cctcgatgat     1500

tttgaccttg acatgcttgg ttcggatgcc cttgatgact ttgacctcga catgctcggc     1560

agtgacgccc ttgatgattt cgacctggac atgctgatta actctagaag ttccggatct     1620

ccgaaaaaga aacgcaaagt tggtagccag tacctgcccg acaccgacga ccggcaccgg     1680

atcgaggaaa agcggaagcg gacctacgag acattcaaga gcatcatgaa gaagtccccc     1740

ttcagcggcc ccaccgaccc tagacctcca cctagaagaa tcgccgtgcc cagcagatcc     1800

agcgccagcg tgccaaaacc tgccccccag ccttacccct tcaccagcag cctgagcacc     1860

atcaactacg acgagttccc taccatggtg ttccccagcg gccagatctc tcaggcctct     1920

gctctggctc cagcccctcc tcaggtgctg cctcaggctc ctgctcctgc accagctcca     1980

gccatggtgt ctgcactggc tcaggcacca gcacccgtgc ctgtgctggc tcctggacct     2040

ccacaggctg tggctccacc agcccctaaa cctacacagg ccggcgaggg cacactgtct     2100

gaagctctgc tgcagctgca gttcgacgac gaggatctgg gagccctgct gggaaacagc     2160

accgatcctg ccgtgttcac cgacctggcc agcgtggaca acagcgagtt ccagcagctg     2220

ctgaaccagg gcatccctgt ggcccctcac accaccgagc ccatgctgat ggaatacccc     2280

gaggccatca cccggctcgt gacaggcgct cagaggcctc ctgatccagc tcctgcccct     2340

ctgggagcac caggcctgcc taatggactg ctgtctggcg acgaggactt cagctctatc     2400

gccgatatgg atttctcagc cttgctg                                         2427


<210> 54
<211> 3015
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 54
atgaagttgc tgagcagcat agagcaagca tgtgatatct gccggttgaa gaagctgaag       60

tgtagcaagg agaagcccaa gtgcgccaag tgtctcaaga ataattggga gtgtaggtat      120

agccccaaga ccaagcgaag cccgcttacg agagcacacc ttaccgaggt cgagagccgc      180

ctggaaagac tcgaacaact ttttcttctg attttcccca gggaggacct ggacatgatc      240

ctgaagatgg acagcctcca ggacatcaaa gcccttctta ccgggctgtt cgtgcaggac      300

aacgtcaaca aggatgcggt gaccgacaga ttggcgagcg tggagacgga catgcccttg      360

accctcagac aacataggat cagcgcgaca agctcatctg aagaatctag caataaggga      420

cagcgacagc tgaccgttag tggggcgtct gcaggcatgg ccagcatgac tggtggacag      480

caaatggggt cgacggagga cgtggtgtgc tgccactcaa tctacggcaa gaagaagggt      540

gatatcgaca cctaccgata cataggctct tccgggacag gctgcgtggt catagtgggc      600

aggatcgtct tgtccggatc cggcactagt gcgcccatca cggcgtacgc ccagcagacg      660

agaggcctcc tagggtgtat aatcaccagc ctgactggcc gggacaaaaa ccaagtggag      720

ggtgaggtcc agatcgtgtc aactgctacc caaaccttcc tggcaacgtg catcaatggg      780

gtatgctggg cagtctacca cggggccgga acgaggacca tcgcatcacc caagggtcct      840

gtcatccaga tgtataccaa tgtggaccaa gaccttgtgg gctggcccgc tcctcaaggt      900

tcccgctcat tgacaccctg tacctgcggc tcctcggacc tttacctggt cacgaggcac      960

gccgatgtca ttcccgtgcg ccggcgaggt gatagcaggg gtagcctgct ttcgccccgg     1020

cccatttcct acttgaaagg ctcctcgggg ggtccgctgt tgtgccccgc gggacacgcc     1080

gtgggcctat tcagggccgc ggtgtgcacc cgtggagtgg ctaaagcggt ggactttatc     1140

cctgtggaga acctagagac aaccatgaga tccccggtgt tcacggacaa ctcctctcca     1200

ccagcagtca ccctgacgca cccaatcacc aaaatcgata gggaggttct ctaccaggag     1260

ttcgatgaga tggaagagtg ctctcagcac tatccctacg atgtgcccga ttacgctggc     1320

gcgtcgtctg catgccccaa gaagaagagg aaggtgtcgc cagggatccg tcgacttgac     1380

gcgttgatat caacaagttt gtacaaaaaa gcaggctaca aagaggccag cggttccgga     1440

cgggctgacg cattggacga ttttgatctg gatatgctgg gaagtgacgc cctcgatgat     1500

tttgaccttg acatgcttgg ttcggatgcc cttgatgact ttgacctcga catgctcggc     1560

agtgacgccc ttgatgattt cgacctggac atgctgatta actctagaag ttccggatct     1620

ccgaaaaaga aacgcaaagt tggtagccag tacctgcccg acaccgacga ccggcaccgg     1680

atcgaggaaa agcggaagcg gacctacgag acattcaaga gcatcatgaa gaagtccccc     1740

ttcagcggcc ccaccgaccc tagacctcca cctagaagaa tcgccgtgcc cagcagatcc     1800

agcgccagcg tgccaaaacc tgccccccag ccttacccct tcaccagcag cctgagcacc     1860

atcaactacg acgagttccc taccatggtg ttccccagcg gccagatctc tcaggcctct     1920

gctctggctc cagcccctcc tcaggtgctg cctcaggctc ctgctcctgc accagctcca     1980

gccatggtgt ctgcactggc tcaggcacca gcacccgtgc ctgtgctggc tcctggacct     2040

ccacaggctg tggctccacc agcccctaaa cctacacagg ccggcgaggg cacactgtct     2100

gaagctctgc tgcagctgca gttcgacgac gaggatctgg gagccctgct gggaaacagc     2160

accgatcctg ccgtgttcac cgacctggcc agcgtggaca acagcgagtt ccagcagctg     2220

ctgaaccagg gcatccctgt ggcccctcac accaccgagc ccatgctgat ggaatacccc     2280

gaggccatca cccggctcgt gacaggcgct cagaggcctc ctgatccagc tcctgcccct     2340

ctgggagcac caggcctgcc taatggactg ctgtctggcg acgaggactt cagctctatc     2400

gccgatatgg atttctcagc cttgctgggc tctggcagcg gcagccggga ttccagggaa     2460

gggatgtttt tgccgaagcc tgaggccggc tccgctatta gtgacgtgtt tgagggccgc     2520

gaggtgtgcc agccaaaacg aatccggcca tttcatcctc caggaagtcc atgggccaac     2580

cgcccactcc ccgccagcct cgcaccaaca ccaaccggtc cagtacatga gccagtcggg     2640

tcactgaccc cggcaccagt ccctcagcca ctggatccag cgcccgcagt gactcccgag     2700

gccagtcacc tgttggagga tcccgatgaa gagacgagcc aggctgtcaa agcccttcgg     2760

gagatggccg atactgtgat tccccagaag gaagaggctg caatctgtgg ccaaatggac     2820

ctttcccatc cgcccccaag gggccatctg gatgagctga caaccacact tgagtccatg     2880

accgaggatc tgaacctgga ctcacccctg accccggaat tgaacgagat tctggatacc     2940

ttcctgaacg acgagtgcct cttgcatgcc atgcatatca gcacaggact gtccatcttc     3000

gacacatctc tgttt                                                      3015


<210> 55
<211> 2601
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 55
atgtctagac tggacaagag caaagtcata aacggagctc tggaattact caatggtgtc       60

ggtatcgaag gcctgacgac aaggaaactc gctcaaaagc tgggagttga gcagcctacc      120

ctgtactggc acgtgaagaa caagcgggcc ctgctcgatg ccctgccaat cgagatgctg      180

gacaggcatc atacccactt ctgccccctg gaaggcgagt catggcaaga ctttctgcgg      240

aacaacgcca agtcataccg ctgtgctctc ctctcacatc gcgacggggc taaagtgcat      300

ctcggcaccc gcccaacaga gaaacagtac gaaaccctgg aaaatcagct cgcgttcctg      360

tgtcagcaag gcttctccct ggagaacgca ctgtacgctc tgtccgccgt gggccacttt      420

acactgggct gcgtattgga ggaacaggag catcaagtag caaaagagga aagagagaca      480

cctaccaccg attctatgcc cccacttctg agacaagcaa ttgagctgtt cgaccggcag      540

ggagccgaac ctgccttcct tttcggcctg gaactaatca tatgtggcct ggagaaacag      600

ctaaagtgcg aaagcggggc gtctgcaggc atggccagca tgactggtgg acagcaaatg      660

gggtcgacgg aggacgtggt gtgctgccac tcaatctacg gcaagaagaa gggtgatatc      720

gacacctacc gatacatagg ctcttccggg acaggctgcg tggtcatagt gggcaggatc      780

gtcttgtccg gatccggcac tagtgcgccc atcacggcgt acgcccagca gacgagaggc      840

ctcctagggt gtataatcac cagcctgact ggccgggaca aaaaccaagt ggagggtgag      900

gtccagatcg tgtcaactgc tacccaaacc ttcctggcaa cgtgcatcaa tggggtatgc      960

tgggcagtct accacggggc cggaacgagg accatcgcat cacccaaggg tcctgtcatc     1020

cagatgtata ccaatgtgga ccaagacctt gtgggctggc ccgctcctca aggttcccgc     1080

tcattgacac cctgtacctg cggctcctcg gacctttacc tggtcacgag gcacgccgat     1140

gtcattcccg tgcgccggcg aggtgatagc aggggtagcc tgctttcgcc ccggcccatt     1200

tcctacttga aaggctcctc ggggggtccg ctgttgtgcc ccgcgggaca cgccgtgggc     1260

ctattcaggg ccgcggtgtg cacccgtgga gtggctaaag cggtggactt tatccctgtg     1320

gagaacctag agacaaccat gagatccccg gtgttcacgg acaactcctc tccaccagca     1380

gtcaccctga cgcacccaat caccaaaatc gatagggagg ttctctacca ggagttcgat     1440

gagatggaag agtgctctca gcactatccc tacgatgtgc ccgattacgc tggcgcgtcg     1500

tctgcatgcc ccaagaagaa gaggaaggtg tcgccaggga tccgtcgact tgacgcgttg     1560

atatcaacaa gtttgtacaa aaaagcaggc tacaaagagg ccagcggttc cggacgggct     1620

gacgcattgg acgattttga tctggatatg ctgggaagtg acgccctcga tgattttgac     1680

cttgacatgc ttggttcgga tgcccttgat gactttgacc tcgacatgct cggcagtgac     1740

gcccttgatg atttcgacct ggacatgctg attaactcta gaagttccgg atctccgaaa     1800

aagaaacgca aagttggtag ccagtacctg cccgacaccg acgaccggca ccggatcgag     1860

gaaaagcgga agcggaccta cgagacattc aagagcatca tgaagaagtc ccccttcagc     1920

ggccccaccg accctagacc tccacctaga agaatcgccg tgcccagcag atccagcgcc     1980

agcgtgccaa aacctgcccc ccagccttac cccttcacca gcagcctgag caccatcaac     2040

tacgacgagt tccctaccat ggtgttcccc agcggccaga tctctcaggc ctctgctctg     2100

gctccagccc ctcctcaggt gctgcctcag gctcctgctc ctgcaccagc tccagccatg     2160

gtgtctgcac tggctcaggc accagcaccc gtgcctgtgc tggctcctgg acctccacag     2220

gctgtggctc caccagcccc taaacctaca caggccggcg agggcacact gtctgaagct     2280

ctgctgcagc tgcagttcga cgacgaggat ctgggagccc tgctgggaaa cagcaccgat     2340

cctgccgtgt tcaccgacct ggccagcgtg gacaacagcg agttccagca gctgctgaac     2400

cagggcatcc ctgtggcccc tcacaccacc gagcccatgc tgatggaata ccccgaggcc     2460

atcacccggc tcgtgacagg cgctcagagg cctcctgatc cagctcctgc ccctctggga     2520

gcaccaggcc tgcctaatgg actgctgtct ggcgacgagg acttcagctc tatcgccgat     2580

atggatttct cagccttgct g                                               2601


<210> 56
<211> 2679
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 56
atggagaccg acaccctgct cctgtgggtg ttgttgctct gggtcccagg ttctaccggc       60

gacggaggag gcggcgaagt acagctggtg gagtccggcg gtggcctcgt gcaacccgga      120

gggtccttga ggctgtcctg tgcagccagc ggtttcacgt tcagcagcta ctggattcac      180

tgggtgaggc aagctccggg caagggcctg gagtgggttg cgaggataaa cccccccaac      240

aggtccaacc agtacgccga tagcgtgaag ggtcggttca ccatcagcgc cgacactagc      300

aagaacacgg cctacctgca gatgaactct ctgagggccg aggacacagc ggtgtactat      360

tgcgccaggg gctcagggtt tcgatgggtc atggattact ggggccaagg caccctggtt      420

accgtttcta gcggcggatc tagcaggagc tcatcatccg ggggtggcgg gagcggaggt      480

ggtggggata ttcagatgac gcaatctccg tcctccctca gcgcaagcgt gggcgacagg      540

gtgaccatta cttgtcgcgc ctctcaggat gtgagcactg ctgtggcctg gtatcaacaa      600

aaacccggca aagcccccaa actgctgatc tactctgcca gctttctgta ctcaggcgtg      660

cccagcaggt tttccggctc cggcagcggc accgacttca cccttaccat tagcagcctg      720

cagcccgagg attttgcaac ctactactgc caacagttct acaccactcc cagcactttc      780

ggccagggca cgaaggttga gatcaagggg ggaggaagtg agcaaaagct gatttccgag      840

gaggaccttg gagggggctc cgccgtgggg caagacaccc aggaggtgat cgtggtgcct      900

catagcctcc ctttcaaagt ggtggtgatt tcagccatcc tggcattggt tgtgctgacc      960

atcataagct tgattatact gatcatgctt tggcagaaga agcccaggcg tacgatggcc     1020

agcatgactg gtggacagca aatggggtcg acggaggacg tggtgtgctg ccactcaatc     1080

tacggcaaga agaagggtga tatcgacacc taccgataca taggctcttc cgggacaggc     1140

tgcgtggtca tagtgggcag gatcgtcttg tccggatccg gcactagtgc gcccatcacg     1200

gcgtacgccc agcagacgag aggcctccta gggtgtataa tcaccagcct gactggccgg     1260

gacaaaaacc aagtggaggg tgaggtccag atcgtgtcaa ctgctaccca aaccttcctg     1320

gcaacgtgca tcaatggggt atgctgggca gtctaccacg gggccggaac gaggaccatc     1380

gcatcaccca agggtcctgt catccagatg tataccaatg tggaccaaga ccttgtgggc     1440

tggcccgctc ctcaaggttc ccgctcattg acaccctgta cctgcggctc ctcggacctt     1500

tacctggtca cgaggcacgc cgatgtcatt cccgtgcgcc ggcgaggtga tagcaggggt     1560

agcctgcttt cgccccggcc catttcctac ttgaaaggct cctcgggggg tccgctgttg     1620

tgccccgcgg gacacgccgt gggcctattc agggccgcgg tgtgcacccg tggagtggct     1680

aaagcggtgg actttatccc tgtggagaac ctagagacaa ccatgagatc cccggtgttc     1740

acggacaact cctctccacc agcagtcacc ctgacgcacc caatcaccaa aatcgatagg     1800

gaggttctct accaggagtt cgatgagatg gaagagtgct ctcagcacta tccctacgat     1860

gtgcccgatt acgctggcgc gtctgcatgc ggtaccatga agttgctgag cagcatagag     1920

caagcatgtg atatctgccg gttgaagaag ctgaagtgta gcaaggagaa gcccaagtgc     1980

gccaagtgtc tcaagaataa ttgggagtgt aggtatagcc ccaagaccaa gcgaagcccg     2040

cttacgagag cacaccttac cgaggtcgag agccgcctgg aaagactcga acaacttttt     2100

cttctgattt tccccaggga ggacctggac atgatcctga agatggacag cctccaggac     2160

atcaaagccc ttcttaccgg gctgttcgtg caggacaacg tcaacaagga tgcggtgacc     2220

gacagattgg cgagcgtgga gacggacatg cccttgaccc tcagacaaca taggatcagc     2280

gcgacaagct catctgaaga atctagcaat aagggacagc gacagctgac cgttagtgcc     2340

aactttaatc aaagtggaaa catcgcggac agctcactca gctttacctt caccaatagc     2400

agtaacgggc cgaacctcat aaccacccag accaacagcc aggccttgag ccagccgatc     2460

gcctcatcta acgtgcatga taactttatg aacaacgaga tcaccgcgag taagatagac     2520

gacgggaaca acagcaagcc ccttagccca ggttggacgg accagaccgc ctacaacgct     2580

ttcggcatta cgaccggcat gttcaacacc acgaccatgg acgatgtgta caactacctg     2640

ttcgatgacg aagacacacc gccaaacccc aaaaaagaa                            2679


<210> 57
<211> 3366
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 57
atggagacag ataccctcct cctttgggtg ctccttctct gggtgcccgg gtccacagga       60

gacgggggcg gaggcatggt ttctaaagga gaggagctca taaaagaaaa catgcatatg      120

aagctctata tggaaggtac cgtagacaac caccatttca aatgcacctc cgagggggag      180

ggtaagcctt atgaaggcac acagacaatg cggattaaag ttgtcgaagg gggaccactc      240

ccctttgcct tcgacatact ggcaacttct ttcctgtacg gcagcaaaac attcatcaat      300

cacactcagg ggataccaga tttcttcaag cagagcttcc ccgaaggctt tacttgggaa      360

cgagtaacta cctacgagga cgggggggtc ctcaccgcca cccaggatac aagtctccag      420

gacgggtgct tgatctacaa tgtaaagata agaggggtaa actttacatc aaacggcccc      480

gtcatgcaaa agaaaaccct tggttgggag gcattcaccg agacactgta ccctgcagac      540

ggaggactcg aaggccgcaa cgatatggct cttaagctcg taggcggtag ccaccttatc      600

gccaacgcta agaccaccta ccgaagtaaa aagccagcca aaaacctgaa aatgcctggt      660

gtttattacg tagactaccg cctcgagcgc atcaaggagg caaacaacga aacctatgtg      720

gagcaacacg aagtcgccgt ggctcgctat tgcgacctgc catctaagtt gggtcacaaa      780

ctcaacggtg gcgggtcaga gcagaaactt atctcagagg aagatctggg tggaggatca      840

gctgtggggc aggataccca agaggtcata gttgtaccac atagtctgcc attcaaggtc      900

gttgttataa gcgctatctt ggccctcgtc gtcctgacca tcatcagctt gattattctc      960

ataatgcttt ggcagaagaa acccagacgg accatggcct caatgactgg agggcagcag     1020

atggggagca ctgaggatgt tgtatgttgt catagcattt atgggaaaaa aaaaggcgac     1080

atcgacacct atagatatat cggaagtagt gggaccggct gcgtggtgat cgtagggcgg     1140

atagtgctgt ctggctccgg cactagtgcg cccatcacgg cgtacgccca gcagacgaga     1200

ggcctcctag ggtgtataat caccagcctg actggccggg acaaaaacca agtggagggt     1260

gaggtccaga tcgtgtcaac tgctacccaa accttcctgg caacgtgcat caatggggta     1320

tgctgggcag tctaccacgg ggccggaacg aggaccatcg catcacccaa gggtcctgtc     1380

atccagatgt ataccaatgt ggaccaagac cttgtgggct ggcccgctcc tcaaggttcc     1440

cgctcattga caccctgtac ctgcggctcc tcggaccttt acctggtcac gaggcacgcc     1500

gatgtcattc ccgtgcgccg gcgaggtgat agcaggggta gcctgctttc gccccggccc     1560

atttcctact tgaaaggctc ctcggggggt ccgctgttgt gccccgcggg acacgccgtg     1620

ggcctattca gggccgcggt gtgcacccgt ggagtggcta aagcggtgga ctttatccct     1680

gtggagaacc tagagacaac catgagatcc ccggtgttca cggacaactc ctctccacca     1740

gcagtcaccc tgacgcaccc aatcaccaaa atcgataggg aggttctcta ccaggagttc     1800

gatgagatgg aagagtgctc tcagcactat ccctacgatg tgcccgatta cgctggcgcg     1860

tctgcatgcg gtaccatgaa gttgctgagc agcatagagc aagcatgtga tatctgccgg     1920

ttgaagaagc tgaagtgtag caaggagaag cccaagtgcg ccaagtgtct caagaataat     1980

tgggagtgta ggtatagccc caagaccaag cgaagcccgc ttacgagagc acaccttacc     2040

gaggtcgaga gccgcctgga aagactcgaa caactttttc ttctgatttt ccccagggag     2100

gacctggaca tgatcctgaa gatggacagc ctccaggaca tcaaagccct tcttaccggg     2160

ctgttcgtgc aggacaacgt caacaaggat gcggtgaccg acagattggc gagcgtggag     2220

acggacatgc ccttgaccct cagacaacat aggatcagcg cgacaagctc atctgaagaa     2280

tctagcaata agggacagcg acagctgacc gttagtatgg tgagcaaggg cgaggaggat     2340

aacatggcca tcatcaagga gttcatgcgc ttcaaggtgc acatggaggg ctccgtgaac     2400

ggccacgagt tcgagatcga gggcgagggc gagggccgcc cctacgaggg cacccagacc     2460

gccaagctga aggtgaccaa gggtggcccc ctgcccttcg cctgggacat cctgtcccct     2520

cagttcatgt acggctccaa ggcctacgtg aagcaccccg ccgacatccc cgactacttg     2580

aagctgtcct tccccgaggg cttcaagtgg gagcgcgtga tgaacttcga ggacggcggc     2640

gtggtgaccg tgacccagga ctcctccctg caggacggcg agttcatcta caaggtgaag     2700

ctgcgcggca ccaacttccc ctccgacggc cccgtaatgc agaagaagac catgggctgg     2760

gaggcctcct ccgagcggat gtaccccgag gacggcgccc tgaagggcga gatcaagcag     2820

aggctgaagc tgaaggacgg cggccactac gacgctgagg tcaagaccac ctacaaggcc     2880

aagaagcccg tgcagctgcc cggcgcctac aacgtcaaca tcaagttgga catcacctcc     2940

cacaacgagg actacaccat cgtggaacag tacgaacgcg ccgagggccg ccactccacc     3000

ggcggcatgg acgagctgta caaggccaac tttaatcaaa gtggaaacat cgcggacagc     3060

tcactcagct ttaccttcac caatagcagt aacgggccga acctcataac cacccagacc     3120

aacagccagg ccttgagcca gccgatcgcc tcatctaacg tgcatgataa ctttatgaac     3180

aacgagatca ccgcgagtaa gatagacgac gggaacaaca gcaagcccct tagcccaggt     3240

tggacggacc agaccgccta caacgctttc ggcattacga ccggcatgtt caacaccacg     3300

accatggacg atgtgtacaa ctacctgttc gatgacgaag acacaccgcc aaaccccaaa     3360

aaagaa                                                                3366


<210> 58
<211> 1731
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 58
atgggctgca tcaagagcaa gcgcaaggac aacctgaacg acgacggcgt ggacatgaag       60

cgtacgatgg ccagcatgac tggtggacag caaatggggt cgacggagga cgtggtgtgc      120

tgccactcaa tctacggcaa gaagaagggt gatatcgaca cctaccgata cataggctct      180

tccgggacag gctgcgtggt catagtgggc aggatcgtct tgtccggatc cggcactagt      240

gcgcccatca cggcgtacgc ccagcagacg agaggcctcc tagggtgtat aatcaccagc      300

ctgactggcc gggacaaaaa ccaagtggag ggtgaggtcc agatcgtgtc aactgctacc      360

caaaccttcc tggcaacgtg catcaatggg gtatgctggg cagtctacca cggggccgga      420

acgaggacca tcgcatcacc caagggtcct gtcatccaga tgtataccaa tgtggaccaa      480

gaccttgtgg gctggcccgc tcctcaaggt tcccgctcat tgacaccctg tacctgcggc      540

tcctcggacc tttacctggt cacgaggcac gccgatgtca ttcccgtgcg ccggcgaggt      600

gatagcaggg gtagcctgct ttcgccccgg cccatttcct acttgaaagg ctcctcgggg      660

ggtccgctgt tgtgccccgc gggacacgcc gtgggcctat tcagggccgc ggtgtgcacc      720

cgtggagtgg ctaaagcggt ggactttatc cctgtggaga acctagagac aaccatgaga      780

tccccggtgt tcacggacaa ctcctctcca ccagcagtca ccctgacgca cccaatcacc      840

aaaatcgata gggaggttct ctaccaggag ttcgatgaga tggaagagtg ctctcagcac      900

tatccctacg atgtgcccga ttacgctggc gcgtctgcat gcggtaccat gaagttgctg      960

agcagcatag agcaagcatg tgatatctgc cggttgaaga agctgaagtg tagcaaggag     1020

aagcccaagt gcgccaagtg tctcaagaat aattgggagt gtaggtatag ccccaagacc     1080

aagcgaagcc cgcttacgag agcacacctt accgaggtcg agagccgcct ggaaagactc     1140

gaacaacttt ttcttctgat tttccccagg gaggacctgg acatgatcct gaagatggac     1200

agcctccagg acatcaaagc ccttcttacc gggctgttcg tgcaggacaa cgtcaacaag     1260

gatgcggtga ccgacagatt ggcgagcgtg gagacggaca tgcccttgac cctcagacaa     1320

cataggatca gcgcgacaag ctcatctgaa gaatctagca ataagggaca gcgacagctg     1380

accgttagtg ccaactttaa tcaaagtgga aacatcgcgg acagctcact cagctttacc     1440

ttcaccaata gcagtaacgg gccgaacctc ataaccaccc agaccaacag ccaggccttg     1500

agccagccga tcgcctcatc taacgtgcat gataacttta tgaacaacga gatcaccgcg     1560

agtaagatag acgacgggaa caacagcaag ccccttagcc caggttggac ggaccagacc     1620

gcctacaacg ctttcggcat tacgaccggc atgttcaaca ccacgaccat ggacgatgtg     1680

tacaactacc tgttcgatga cgaagacaca ccgccaaacc ccaaaaaaga a              1731


<210> 59
<211> 2487
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 59
atggagaccg acaccctgct cctgtgggtg ttgttgctct gggtcccagg ttctaccggc       60

gacggaggag gcggcgaagt acagctggtg gagtccggcg gtggcctcgt gcaacccgga      120

gggtccttga ggctgtcctg tgcagccagc ggtttcacgt tcagcagcta ctggattcac      180

tgggtgaggc aagctccggg caagggcctg gagtgggttg cgaggataaa cccccccaac      240

aggtccaacc agtacgccga tagcgtgaag ggtcggttca ccatcagcgc cgacactagc      300

aagaacacgg cctacctgca gatgaactct ctgagggccg aggacacagc ggtgtactat      360

tgcgccaggg gctcagggtt tcgatgggtc atggattact ggggccaagg caccctggtt      420

accgtttcta gcggcggatc tagcaggagc tcatcatccg ggggtggcgg gagcggaggt      480

ggtggggata ttcagatgac gcaatctccg tcctccctca gcgcaagcgt gggcgacagg      540

gtgaccatta cttgtcgcgc ctctcaggat gtgagcactg ctgtggcctg gtatcaacaa      600

aaacccggca aagcccccaa actgctgatc tactctgcca gctttctgta ctcaggcgtg      660

cccagcaggt tttccggctc cggcagcggc accgacttca cccttaccat tagcagcctg      720

cagcccgagg attttgcaac ctactactgc caacagttct acaccactcc cagcactttc      780

ggccagggca cgaaggttga gatcaagggg ggaggaagtg agcaaaagct gatttccgag      840

gaggaccttg gagggggctc cgccgtgggg caagacaccc aggaggtgat cgtggtgcct      900

catagcctcc ctttcaaagt ggtggtgatt tcagccatcc tggcattggt tgtgctgacc      960

atcataagct tgattatact gatcatgctt tggcagaaga agcccaggcg tacgatggcc     1020

agcatgactg gtggacagca aatggggtcg acggaggacg tggtgtgctg ccactcaatc     1080

tacggcaaga agaagggtga tatcgacacc taccgataca taggctcttc cgggacaggc     1140

tgcgtggtca tagtgggcag gatcgtcttg tccggatccg gcactagtgc gcccatcacg     1200

gcgtacgccc agcagacgag aggcctccta gggtgtataa tcaccagcct gactggccgg     1260

gacaaaaacc aagtggaggg tgaggtccag atcgtgtcaa ctgctaccca aaccttcctg     1320

gcaacgtgca tcaatggggt atgctgggca gtctaccacg gggccggaac gaggaccatc     1380

gcatcaccca agggtcctgt catccagatg tataccaatg tggaccaaga ccttgtgggc     1440

tggcccgctc ctcaaggttc ccgctcattg acaccctgta cctgcggctc ctcggacctt     1500

tacctggtca cgaggcacgc cgatgtcatt cccgtgcgcc ggcgaggtga tagcaggggt     1560

agcctgcttt cgccccggcc catttcctac ttgaaaggct cctcgggggg tccgctgttg     1620

tgccccgcgg gacacgccgt gggcctattc agggccgcgg tgtgcacccg tggagtggct     1680

aaagcggtgg actttatccc tgtggagaac ctagagacaa ccatgagatc cccggtgttc     1740

acggacaact cctctccacc agcagtcacc ctgacgcacc caatcaccaa aatcgatagg     1800

gaggttctct accaggagtt cgatgagatg gaagagtgct ctcagcacta tccctacgat     1860

gtgcccgatt acgctggcgc gtctgcatgc ggtaccatga agttgctgag cagcatagag     1920

caagcatgtg atatctgccg gttgaagaag ctgaagtgta gcaaggagaa gcccaagtgc     1980

gccaagtgtc tcaagaataa ttgggagtgt aggtatagcc ccaagaccaa gcgaagcccg     2040

cttacgagag cacaccttac cgaggtcgag agccgcctgg aaagactcga acaacttttt     2100

cttctgattt tccccaggga ggacctggac atgatcctga agatggacag cctccaggac     2160

atcaaagccc ttcttaccgg gctgttcgtg caggacaacg tcaacaagga tgcggtgacc     2220

gacagattgg cgagcgtgga gacggacatg cccttgaccc tcagacaaca taggatcagc     2280

gcgacaagct catctgaaga atctagcaat aagggacagc gacagctgac cgttagtgac     2340

gcattggacg attttgatct ggatatgctg ggaagtgacg ccctcgatga ttttgacctt     2400

gacatgcttg gttcggatgc ccttgatgac tttgacctcg acatgctcgg cagtgacgcc     2460

cttgatgatt tcgacctgga catgctg                                         2487


<210> 60
<211> 6675
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 60
atggacaaga agtactccat tgggctcgct atcggcacaa acagcgtcgg ctgggccgtc       60

attacggacg agtacaaggt gccgagcaaa aaattcaaag ttctgggcaa taccgatcgc      120

cacagcataa agaagaacct cattggcgcc ctcctgttcg actccgggga gacggccgaa      180

gccacgcggc tcaaaagaac agcacggcgc agatataccc gcagaaagaa tcggatctgc      240

tacctgcagg agatctttag taatgagatg gctaaggtgg atgactcttt cttccatagg      300

ctggaggagt cctttttggt ggaggaggat aaaaagcacg agcgccaccc aatctttggc      360

aatatcgtgg acgaggtggc gtaccatgaa aagtacccaa ccatatatca tctgaggaag      420

aagcttgtag acagtactga taaggctgac ttgcggttga tctatctcgc gctggcgcat      480

atgatcaaat ttcggggaca cttcctcatc gagggggacc tgaacccaga caacagcgat      540

gtcgacaaac tctttatcca actggttcag acttacaatc agcttttcga agagaacccg      600

atcaacgcat ccggagttga cgccaaagca atcctgagcg ctaggctgtc caaatcccgg      660

cggctcgaaa acctcatcgc acagctccct ggggagaaga agaacggcct gtttggtaat      720

cttatcgccc tgtcactcgg gctgaccccc aactttaaat ctaacttcga cctggccgaa      780

gatgccaagc ttcaactgag caaagacacc tacgatgatg atctcgacaa tctgctggcc      840

cagatcggcg accagtacgc agaccttttt ttggcggcaa agaacctgtc agacgccatt      900

ctgctgagtg atattctgcg agtgaacacg gagatcacca aagctccgct gagcgctagt      960

atgatcaagc gctatgatga gcaccaccaa gacttgactt tgctgaaggc ccttgtcaga     1020

cagcaactgc ctgagaagta caaggaaatt ttcttcgatc agtctaaaaa tggctacgcc     1080

ggatacattg acggcggagc aagccaggag gaattttaca aatttattaa gcccatcttg     1140

gaaaaaatgg acggcaccga ggagctgctg gtaaagctta acagagaaga tctgttgcgc     1200

aaacagcgca ctttcgacaa tggaagcatc ccccaccaga ttcacctggg cgaactgcac     1260

gctatcctca ggcggcaaga ggatttctac ccctttttga aagataacag ggaaaagatt     1320

gagaaaatcc tcacatttcg gataccctac tatgtaggcc ccctcgcccg gggaaattcc     1380

agattcgcgt ggatgactcg caaatcagaa gagaccatca ctccctggaa cttcgaggaa     1440

gtcgtggata agggggcctc tgcccagtcc ttcatcgaaa ggatgactaa ctttgataaa     1500

aatctgccta acgaaaaggt gcttcctaaa cactctctgc tgtacgagta cttcacagtt     1560

tataacgagc tcaccaaggt caaatacgtc acagaaggga tgagaaagcc agcattcctg     1620

tctggagagc agaagaaagc tatcgtggac ctcctcttca agacgaaccg gaaagttacc     1680

gtgaaacagc tcaaagaaga ctatttcaaa aagattgaat gtttcgactc tgttgaaatc     1740

agcggagtgg aggatcgctt caacgcatcc ctgggaacgt atcacgatct cctgaaaatc     1800

attaaagaca aggacttcct ggacaatgag gagaacgagg acattcttga ggacattgtc     1860

ctcaccctta cgttgtttga agatagggag atgattgaag aacgcttgaa aacttacgct     1920

catctcttcg acgacaaagt catgaaacag ctcaagaggc gccgatatac aggatggggg     1980

cggctgtcaa gaaaactgat caatgggatc cgagacaagc agagtggaaa gacaatcctg     2040

gattttctta agtccgatgg atttgccaac cggaacttca tgcagttgat ccatgatgac     2100

tctctcacct ttaaggagga catccagaaa gcacaagttt ctggccaggg ggacagtctt     2160

cacgagcaca tcgctaatct tgcaggtagc ccagctatca aaaagggaat actgcagacc     2220

gttaaggtcg tggatgaact cgtcaaagta atgggaaggc ataagcccga gaatatcgtt     2280

atcgagatgg cccgagagaa ccaaactacc cagaagggac agaagaacag tagggaaagg     2340

atgaagagga ttgaagaggg tataaaagaa ctggggtccc aaatccttaa ggaacaccca     2400

gttgaaaaca cccagcttca gaatgagaag ctctacctgt actacctgca gaacggcagg     2460

gacatgtacg tggatcagga actggacatc aatcggctct ccgactacga cgtggctgct     2520

atcgtgcccc agtcttttct caaagatgat tctattgata ataaagtgtt gacaagatcc     2580

gataaagcta gagggaagag tgataacgtc ccctcagaag aagttgtcaa gaaaatgaaa     2640

aattattggc ggcagctgct gaacgccaaa ctgatcacac aacggaagtt cgataatctg     2700

actaaggctg aacgaggtgg cctgtctgag ttggataaag ccggcttcat caaaaggcag     2760

cttgttgaga cacgccagat caccaagcac gtggcccaaa ttctcgattc acgcatgaac     2820

accaagtacg atgaaaatga caaactgatt cgagaggtga aagttattac tctgaagtct     2880

aagctggtct cagatttcag aaaggacttt cagttttata aggtgagaga gatcaacaat     2940

taccaccatg cgcatgatgc ctacctgaat gcagtggtag gcactgcact tatcaaaaaa     3000

tatcccaagc ttgaatctga atttgtttac ggagactata aagtgtacga tgttaggaaa     3060

atgatcgcaa agtctgagca ggaaataggc aaggccaccg ctaagtactt cttttacagc     3120

aatattatga attttttcaa gaccgagatt acactggcca atggagagat tcggaagcga     3180

ccacttatcg aaacaaacgg agaaacagga gaaatcgtgt gggacaaggg tagggatttc     3240

gcgacagtcc ggaaggtcct gtccatgccg caggtgaaca tcgttaaaaa gaccgaagta     3300

cagaccggag gcttctccaa ggaaagtatc ctcccgaaaa ggaacagcga caagctgatc     3360

gcacgcaaaa aagattggga ccccaagaaa tacggcggat tcgattctcc tacagtcgct     3420

tacagtgtac tggttgtggc caaagtggag aaagggaagt ctaaaaaact caaaagcgtc     3480

aaggaactgc tgggcatcac aatcatggag cgatcaagct tcgaaaaaaa ccccatcgac     3540

tttctcgagg cgaaaggata taaagaggtc aaaaaagacc tcatcattaa gcttcccaag     3600

tactctctct ttgagcttga aaacggccgg aaacgaatgc tcgctagtgc gggcgagctg     3660

cagaaaggta acgagctggc actgccctct aaatacgtta atttcttgta tctggccagc     3720

cactatgaaa agctcaaagg gtctcccgaa gataatgagc agaagcagct gttcgtggaa     3780

caacacaaac actaccttga tgagatcatc gagcaaataa gcgaattctc caaaagagtg     3840

atcctcgccg acgctaacct cgataaggtg ctttctgctt acaataagca cagggataag     3900

cccatcaggg agcaggcaga aaacattatc cacttgttta ctctgaccaa cttgggcgcg     3960

cctgcagcct tcaagtactt cgacaccacc atagacagaa agcggtacac ctctacaaag     4020

gaggtcctgg acgccacact gattcatcag tcaattacgg ggctctatga aacaagaatc     4080

gacctctctc agctcggtgg agacagcagg gctgacatgg ccagcatgac tggtggacag     4140

caaatggggt cgacggagga cgtggtgtgc tgccactcaa tctacggcaa gaagaagggt     4200

gatatcgaca cctaccgata cataggctct tccgggacag gctgcgtggt catagtgggc     4260

aggatcgtct tgtccggatc cggcactagt gcgcccatca cggcgtacgc ccagcagacg     4320

agaggcctcc tagggtgtat aatcaccagc ctgactggcc gggacaaaaa ccaagtggag     4380

ggtgaggtcc agatcgtgtc aactgctacc caaaccttcc tggcaacgtg catcaatggg     4440

gtatgctggg cagtctacca cggggccgga acgaggacca tcgcatcacc caagggtcct     4500

gtcatccaga tgtataccaa tgtggaccaa gaccttgtgg gctggcccgc tcctcaaggt     4560

tcccgctcat tgacaccctg tacctgcggc tcctcggacc tttacctggt cacgaggcac     4620

gccgatgtca ttcccgtgcg ccggcgaggt gatagcaggg gtagcctgct ttcgccccgg     4680

cccatttcct acttgaaagg ctcctcgggg ggtccgctgt tgtgccccgc gggacacgcc     4740

gtgggcctat tcagggccgc ggtgtgcacc cgtggagtgg ctaaagcggt ggactttatc     4800

cctgtggaga acctagagac aaccatgaga tccccggtgt tcacggacaa ctcctctcca     4860

ccagcagtca ccctgacgca cccaatcacc aaaatcgata gggaggttct ctaccaggag     4920

ttcgatgaga tggaagagtg ctctcagcac tatccctacg atgtgcccga ttacgctggc     4980

gcgtctgcat gccccaagaa gaagaggaag gtgtcgccag ggatccgtcg acttgacgcg     5040

ttgatatcaa caagtttgta caaaaaagca ggctacaaag aggccagcgg ttccggacgg     5100

gctgacgcat tggacgattt tgatctggat atgctgggaa gtgacgccct cgatgatttt     5160

gaccttgaca tgcttggttc ggatgccctt gatgactttg acctcgacat gctcggcagt     5220

gacgcccttg atgatttcga cctggacatg ctgattaact ctagaagttc cggatctccg     5280

aaaaagaaac gcaaagttgg tagccagtac ctgcccgaca ccgacgaccg gcaccggatc     5340

gaggaaaagc ggaagcggac ctacgagaca ttcaagagca tcatgaagaa gtcccccttc     5400

agcggcccca ccgaccctag acctccacct agaagaatcg ccgtgcccag cagatccagc     5460

gccagcgtgc caaaacctgc cccccagcct taccccttca ccagcagcct gagcaccatc     5520

aactacgacg agttccctac catggtgttc cccagcggcc agatctctca ggcctctgct     5580

ctggctccag cccctcctca ggtgctgcct caggctcctg ctcctgcacc agctccagcc     5640

atggtgtctg cactggctca ggcaccagca cccgtgcctg tgctggctcc tggacctcca     5700

caggctgtgg ctccaccagc ccctaaacct acacaggccg gcgagggcac actgtctgaa     5760

gctctgctgc agctgcagtt cgacgacgag gatctgggag ccctgctggg aaacagcacc     5820

gatcctgccg tgttcaccga cctggccagc gtggacaaca gcgagttcca gcagctgctg     5880

aaccagggca tccctgtggc ccctcacacc accgagccca tgctgatgga ataccccgag     5940

gccatcaccc ggctcgtgac aggcgctcag aggcctcctg atccagctcc tgcccctctg     6000

ggagcaccag gcctgcctaa tggactgctg tctggcgacg aggacttcag ctctatcgcc     6060

gatatggatt tctcagcctt gctgggctct ggcagcggca gccgggattc cagggaaggg     6120

atgtttttgc cgaagcctga ggccggctcc gctattagtg acgtgtttga gggccgcgag     6180

gtgtgccagc caaaacgaat ccggccattt catcctccag gaagtccatg ggccaaccgc     6240

ccactccccg ccagcctcgc accaacacca accggtccag tacatgagcc agtcgggtca     6300

ctgaccccgg caccagtccc tcagccactg gatccagcgc ccgcagtgac tcccgaggcc     6360

agtcacctgt tggaggatcc cgatgaagag acgagccagg ctgtcaaagc ccttcgggag     6420

atggccgata ctgtgattcc ccagaaggaa gaggctgcaa tctgtggcca aatggacctt     6480

tcccatccgc ccccaagggg ccatctggat gagctgacaa ccacacttga gtccatgacc     6540

gaggatctga acctggactc acccctgacc ccggaattga acgagattct ggataccttc     6600

ctgaacgacg agtgcctctt gcatgccatg catatcagca caggactgtc catcttcgac     6660

acatctctgt tttga                                                      6675


<210> 61
<211> 7239
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 61
atggacaaag actgcgaaat gaagcgcacc accctggata gccctctggg caagctggaa       60

ctgtctgggt gcgaacaggg cctgcaccgt atcatcttcc tgggcaaagg aacatctgcc      120

gccgacgccg tggaagtgcc tgccccagcc gccgtgctgg gcggaccaga gccactgatg      180

caggccaccg cctggctcaa cgcctacttt caccagcctg aggccatcga ggagttccct      240

gtgccagccc tgcaccaccc agtgttccag caggagagct ttacccgcca ggtgctgtgg      300

aaactgctga aagtggtgaa gttcggagag gtcatcagct acagccacct ggccgccctg      360

gccggcaatc ccgccgccac cgccgccgtg aaaaccgccc tgagcggaaa tcccgtgccc      420

attctgatcc cctgccaccg ggtggtgcag ggcgacctgg acgtgggggg ctacgagggc      480

gggctcgccg tgaaagagtg gctgctggcc cacgagggcc acagactggg caagcctggg      540

ctgggtcctg caggcgacgc caccatggac aagaagtact ccattgggct cgctatcggc      600

acaaacagcg tcggctgggc cgtcattacg gacgagtaca aggtgccgag caaaaaattc      660

aaagttctgg gcaataccga tcgccacagc ataaagaaga acctcattgg cgccctcctg      720

ttcgactccg gggagacggc cgaagccacg cggctcaaaa gaacagcacg gcgcagatat      780

acccgcagaa agaatcggat ctgctacctg caggagatct ttagtaatga gatggctaag      840

gtggatgact ctttcttcca taggctggag gagtcctttt tggtggagga ggataaaaag      900

cacgagcgcc acccaatctt tggcaatatc gtggacgagg tggcgtacca tgaaaagtac      960

ccaaccatat atcatctgag gaagaagctt gtagacagta ctgataaggc tgacttgcgg     1020

ttgatctatc tcgcgctggc gcatatgatc aaatttcggg gacacttcct catcgagggg     1080

gacctgaacc cagacaacag cgatgtcgac aaactcttta tccaactggt tcagacttac     1140

aatcagcttt tcgaagagaa cccgatcaac gcatccggag ttgacgccaa agcaatcctg     1200

agcgctaggc tgtccaaatc ccggcggctc gaaaacctca tcgcacagct ccctggggag     1260

aagaagaacg gcctgtttgg taatcttatc gccctgtcac tcgggctgac ccccaacttt     1320

aaatctaact tcgacctggc cgaagatgcc aagcttcaac tgagcaaaga cacctacgat     1380

gatgatctcg acaatctgct ggcccagatc ggcgaccagt acgcagacct ttttttggcg     1440

gcaaagaacc tgtcagacgc cattctgctg agtgatattc tgcgagtgaa cacggagatc     1500

accaaagctc cgctgagcgc tagtatgatc aagcgctatg atgagcacca ccaagacttg     1560

actttgctga aggcccttgt cagacagcaa ctgcctgaga agtacaagga aattttcttc     1620

gatcagtcta aaaatggcta cgccggatac attgacggcg gagcaagcca ggaggaattt     1680

tacaaattta ttaagcccat cttggaaaaa atggacggca ccgaggagct gctggtaaag     1740

cttaacagag aagatctgtt gcgcaaacag cgcactttcg acaatggaag catcccccac     1800

cagattcacc tgggcgaact gcacgctatc ctcaggcggc aagaggattt ctaccccttt     1860

ttgaaagata acagggaaaa gattgagaaa atcctcacat ttcggatacc ctactatgta     1920

ggccccctcg cccggggaaa ttccagattc gcgtggatga ctcgcaaatc agaagagacc     1980

atcactccct ggaacttcga ggaagtcgtg gataaggggg cctctgccca gtccttcatc     2040

gaaaggatga ctaactttga taaaaatctg cctaacgaaa aggtgcttcc taaacactct     2100

ctgctgtacg agtacttcac agtttataac gagctcacca aggtcaaata cgtcacagaa     2160

gggatgagaa agccagcatt cctgtctgga gagcagaaga aagctatcgt ggacctcctc     2220

ttcaagacga accggaaagt taccgtgaaa cagctcaaag aagactattt caaaaagatt     2280

gaatgtttcg actctgttga aatcagcgga gtggaggatc gcttcaacgc atccctggga     2340

acgtatcacg atctcctgaa aatcattaaa gacaaggact tcctggacaa tgaggagaac     2400

gaggacattc ttgaggacat tgtcctcacc cttacgttgt ttgaagatag ggagatgatt     2460

gaagaacgct tgaaaactta cgctcatctc ttcgacgaca aagtcatgaa acagctcaag     2520

aggcgccgat atacaggatg ggggcggctg tcaagaaaac tgatcaatgg gatccgagac     2580

aagcagagtg gaaagacaat cctggatttt cttaagtccg atggatttgc caaccggaac     2640

ttcatgcagt tgatccatga tgactctctc acctttaagg aggacatcca gaaagcacaa     2700

gtttctggcc agggggacag tcttcacgag cacatcgcta atcttgcagg tagcccagct     2760

atcaaaaagg gaatactgca gaccgttaag gtcgtggatg aactcgtcaa agtaatggga     2820

aggcataagc ccgagaatat cgttatcgag atggcccgag agaaccaaac tacccagaag     2880

ggacagaaga acagtaggga aaggatgaag aggattgaag agggtataaa agaactgggg     2940

tcccaaatcc ttaaggaaca cccagttgaa aacacccagc ttcagaatga gaagctctac     3000

ctgtactacc tgcagaacgg cagggacatg tacgtggatc aggaactgga catcaatcgg     3060

ctctccgact acgacgtggc tgctatcgtg ccccagtctt ttctcaaaga tgattctatt     3120

gataataaag tgttgacaag atccgataaa gctagaggga agagtgataa cgtcccctca     3180

gaagaagttg tcaagaaaat gaaaaattat tggcggcagc tgctgaacgc caaactgatc     3240

acacaacgga agttcgataa tctgactaag gctgaacgag gtggcctgtc tgagttggat     3300

aaagccggct tcatcaaaag gcagcttgtt gagacacgcc agatcaccaa gcacgtggcc     3360

caaattctcg attcacgcat gaacaccaag tacgatgaaa atgacaaact gattcgagag     3420

gtgaaagtta ttactctgaa gtctaagctg gtctcagatt tcagaaagga ctttcagttt     3480

tataaggtga gagagatcaa caattaccac catgcgcatg atgcctacct gaatgcagtg     3540

gtaggcactg cacttatcaa aaaatatccc aagcttgaat ctgaatttgt ttacggagac     3600

tataaagtgt acgatgttag gaaaatgatc gcaaagtctg agcaggaaat aggcaaggcc     3660

accgctaagt acttctttta cagcaatatt atgaattttt tcaagaccga gattacactg     3720

gccaatggag agattcggaa gcgaccactt atcgaaacaa acggagaaac aggagaaatc     3780

gtgtgggaca agggtaggga tttcgcgaca gtccggaagg tcctgtccat gccgcaggtg     3840

aacatcgtta aaaagaccga agtacagacc ggaggcttct ccaaggaaag tatcctcccg     3900

aaaaggaaca gcgacaagct gatcgcacgc aaaaaagatt gggaccccaa gaaatacggc     3960

ggattcgatt ctcctacagt cgcttacagt gtactggttg tggccaaagt ggagaaaggg     4020

aagtctaaaa aactcaaaag cgtcaaggaa ctgctgggca tcacaatcat ggagcgatca     4080

agcttcgaaa aaaaccccat cgactttctc gaggcgaaag gatataaaga ggtcaaaaaa     4140

gacctcatca ttaagcttcc caagtactct ctctttgagc ttgaaaacgg ccggaaacga     4200

atgctcgcta gtgcgggcga gctgcagaaa ggtaacgagc tggcactgcc ctctaaatac     4260

gttaatttct tgtatctggc cagccactat gaaaagctca aagggtctcc cgaagataat     4320

gagcagaagc agctgttcgt ggaacaacac aaacactacc ttgatgagat catcgagcaa     4380

ataagcgaat tctccaaaag agtgatcctc gccgacgcta acctcgataa ggtgctttct     4440

gcttacaata agcacaggga taagcccatc agggagcagg cagaaaacat tatccacttg     4500

tttactctga ccaacttggg cgcgcctgca gccttcaagt acttcgacac caccatagac     4560

agaaagcggt acacctctac aaaggaggtc ctggacgcca cactgattca tcagtcaatt     4620

acggggctct atgaaacaag aatcgacctc tctcagctcg gtggagacag cagggctgac     4680

atggccagca tgactggtgg acagcaaatg gggtcgacgg aggacgtggt gtgctgccac     4740

tcaatctacg gcaagaagaa gggtgatatc gacacctacc gatacatagg ctcttccggg     4800

acaggctgcg tggtcatagt gggcaggatc gtcttgtccg gatccggcac tagtgcgccc     4860

atcacggcgt acgcccagca gacgagaggc ctcctagggt gtataatcac cagcctgact     4920

ggccgggaca aaaaccaagt ggagggtgag gtccagatcg tgtcaactgc tacccaaacc     4980

ttcctggcaa cgtgcatcaa tggggtatgc tgggcagtct accacggggc cggaacgagg     5040

accatcgcat cacccaaggg tcctgtcatc cagatgtata ccaatgtgga ccaagacctt     5100

gtgggctggc ccgctcctca aggttcccgc tcattgacac cctgtacctg cggctcctcg     5160

gacctttacc tggtcacgag gcacgccgat gtcattcccg tgcgccggcg aggtgatagc     5220

aggggtagcc tgctttcgcc ccggcccatt tcctacttga aaggctcctc ggggggtccg     5280

ctgttgtgcc ccgcgggaca cgccgtgggc ctattcaggg ccgcggtgtg cacccgtgga     5340

gtggctaaag cggtggactt tatccctgtg gagaacctag agacaaccat gagatccccg     5400

gtgttcacgg acaactcctc tccaccagca gtcaccctga cgcacccaat caccaaaatc     5460

gatagggagg ttctctacca ggagttcgat gagatggaag agtgctctca gcactatccc     5520

tacgatgtgc ccgattacgc tggcgcgtct gcatgcccca agaagaagag gaaggtgtcg     5580

ccagggatcc gtcgacttga cgcgttgata tcaacaagtt tgtacaaaaa agcaggctac     5640

aaagaggcca gcggttccgg acgggctgac gcattggacg attttgatct ggatatgctg     5700

ggaagtgacg ccctcgatga ttttgacctt gacatgcttg gttcggatgc ccttgatgac     5760

tttgacctcg acatgctcgg cagtgacgcc cttgatgatt tcgacctgga catgctgatt     5820

aactctagaa gttccggatc tccgaaaaag aaacgcaaag ttggtagcca gtacctgccc     5880

gacaccgacg accggcaccg gatcgaggaa aagcggaagc ggacctacga gacattcaag     5940

agcatcatga agaagtcccc cttcagcggc cccaccgacc ctagacctcc acctagaaga     6000

atcgccgtgc ccagcagatc cagcgccagc gtgccaaaac ctgcccccca gccttacccc     6060

ttcaccagca gcctgagcac catcaactac gacgagttcc ctaccatggt gttccccagc     6120

ggccagatct ctcaggcctc tgctctggct ccagcccctc ctcaggtgct gcctcaggct     6180

cctgctcctg caccagctcc agccatggtg tctgcactgg ctcaggcacc agcacccgtg     6240

cctgtgctgg ctcctggacc tccacaggct gtggctccac cagcccctaa acctacacag     6300

gccggcgagg gcacactgtc tgaagctctg ctgcagctgc agttcgacga cgaggatctg     6360

ggagccctgc tgggaaacag caccgatcct gccgtgttca ccgacctggc cagcgtggac     6420

aacagcgagt tccagcagct gctgaaccag ggcatccctg tggcccctca caccaccgag     6480

cccatgctga tggaataccc cgaggccatc acccggctcg tgacaggcgc tcagaggcct     6540

cctgatccag ctcctgcccc tctgggagca ccaggcctgc ctaatggact gctgtctggc     6600

gacgaggact tcagctctat cgccgatatg gatttctcag ccttgctggg ctctggcagc     6660

ggcagccggg attccaggga agggatgttt ttgccgaagc ctgaggccgg ctccgctatt     6720

agtgacgtgt ttgagggccg cgaggtgtgc cagccaaaac gaatccggcc atttcatcct     6780

ccaggaagtc catgggccaa ccgcccactc cccgccagcc tcgcaccaac accaaccggt     6840

ccagtacatg agccagtcgg gtcactgacc ccggcaccag tccctcagcc actggatcca     6900

gcgcccgcag tgactcccga ggccagtcac ctgttggagg atcccgatga agagacgagc     6960

caggctgtca aagcccttcg ggagatggcc gatactgtga ttccccagaa ggaagaggct     7020

gcaatctgtg gccaaatgga cctttcccat ccgcccccaa ggggccatct ggatgagctg     7080

acaaccacac ttgagtccat gaccgaggat ctgaacctgg actcacccct gaccccggaa     7140

ttgaacgaga ttctggatac cttcctgaac gacgagtgcc tcttgcatgc catgcatatc     7200

agcacaggac tgtccatctt cgacacatct ctgttttga                            7239


<210> 62
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 62
gcagacgcga ggaaggaggg cgc                                               23


<210> 63
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 63
gcctctggga ggtcctgtcc ggctc                                             25


<210> 64
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 64
tgggtcttcg gaggacagta ctc                                               23


<210> 65
<211> 3735
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 65
atgggccgtc ggagcgctct agcccttgcc gtggtctcag ccctgctgtg ccaggtctgg       60

agctctggcg tatttgagct gaagctgcag gagttcgtca acaagaaggg gctgctgggg      120

aaccgcaact gctgccgcgg gggctctggc ccgccgtgcg cctgcaggac cttctttcgc      180

gtatgcctca agcattacca ggccagcgtg tccccggagc caccctgcac ctacggcagt      240

gcggtcaccg cagtgctggg tgtcgactcc ttcagcctgc ctgatggcgc aggcatcgac      300

cccgccttca gcaaccccat ccgattcccc ttcggattca cctggccagg taccttctct      360

ctgatcattg aagccctcca cacagattct cctgacgacc tcgcaacaga aaacccagaa      420

agactcatca gccgcctgac cacacagagg cacctcactg tgggagaaga gtggtctcag      480

gaccttcaca gtagcggccg cacagacctc cgctactctt accggtttgt gtgtgatgaa      540

cactactatg gagaaggctg ctccgtgttc tgccgaccgc gggatgatgc ctttggccac      600

ttcacctgcg gggagagagg ggagaagatg tgcgaccctg gctggaaagg ccagtactgc      660

actgacccca tttgtctgcc aggctgtgat gaccaacatg gatattgtga caaaccgggg      720

gaatgcaagt gcagagttgg ctggcagggc cgctactgcg atgaatgcat ccgataccca      780

ggctgtctcc atggtacctg ccagcagccc tggcagtgta actgccagga aggctggggg      840

ggcctcttct gcaaccagga tctgaactac tgcactcacc ataagccatg caggaacgga      900

gccacctgca ccaacacggg ccaggggagc tacacatgct cttgccgacc cgggtataca      960

ggggccaact gtgagctgga ggtagatgag tgtgctccca gcccctgcag gaatggaggg     1020

agctgcacgg atcttgagga cagctactct tgcacctgcc ctcctggctt ctatggcaag     1080

gtctgtgagc tgagcgccat gacgtgtgca gatggtcctt gcttcaatgg gggacgatgt     1140

tcggataacc ccgatggagg ctacacctgc cattgccctg cgggcttctc tggcttcaac     1200

tgtgagaaga agattgatct ctgtagctct tccccttgtt ctaacggtgc caagtgtgtg     1260

gacctcggca actcctacct gtgccgatgt cagactggct tctccgggag gtactgcgag     1320

gacaatgtgg atgactgtgc ctcttctccc tgtgcaaacg ggggcacctg ccgggacagt     1380

gtgaacgatt tctcctgtac ctgcccacct ggctacacag gcaggaactg cagcgcccct     1440

gtcagcaggt gtgagcatgc accctgtcat aacggggcca cctgccacca gaggggccaa     1500

cgctacatgt gtgagtgcgc ccagggctat ggcggcgcca actgccagtt cctgctccct     1560

gagccaccac cagacctcat agtggcggcc cagggcgggt ccttcccctg gagcagggct     1620

gacatggcca gcatgactgg tggacagcaa atggggtcga cggaggacgt ggtgtgctgc     1680

cactcaatct acggcaagaa gaagggtgat atcgacacct accgatacat aggctcttcc     1740

gggacaggct gcgtggtcat agtgggcagg atcgtcttgt ccggatccgg cactagtgcg     1800

cccatcacgg cgtacgccca gcagacgaga ggcctcctag ggtgtataat caccagcctg     1860

actggccggg acaaaaacca agtggagggt gaggtccaga tcgtgtcaac tgctacccaa     1920

accttcctgg caacgtgcat caatggggta tgctgggcag tctaccacgg ggccggaacg     1980

aggaccatcg catcacccaa gggtcctgtc atccagatgt ataccaatgt ggaccaagac     2040

cttgtgggct ggcccgctcc tcaaggttcc cgctcattga caccctgtac ctgcggctcc     2100

tcggaccttt acctggtcac gaggcacgcc gatgtcattc ccgtgcgccg gcgaggtgat     2160

agcaggggta gcctgctttc gccccggccc atttcctact tgaaaggctc ctcggggggt     2220

ccgctgttgt gccccgcggg acacgccgtg ggcctattca gggccgcggt gtgcacccgt     2280

ggagtggcta aagcggtgga ctttatccct gtggagaacc tagagacaac catgagatcc     2340

ccggtgttca cggacaactc ctctccacca gcagtcaccc tgacgcaccc aatcaccaaa     2400

atcgataggg aggttctcta ccaggagttc gatgagatgg aagagtgctc tcagcactat     2460

ccctacgatg tgcccgatta cgctggcgcg tctgcagtgg ctgtgtgtgc cggggtggtg     2520

cttgtcctcc tgctgctgct gggctgtgct gctgtggtgg tctgcgtccg gctgaagcta     2580

cagaaacacc agcctccgcc tgatccttgc gggggagaga cagagaccat gaacaaccta     2640

gccaattgcc agcgtgagaa ggatgtttct gttagcatca ttggggctac acagatcaag     2700

aacaccaaca agaaggcgga ctttcatggg gaccatggtg ctgacaagag cagctttaag     2760

gcccgatacc ccactgtgga ctataacctc attcgagacc tcaagggaga tgaagccacg     2820

gtcagggatg cacacagcaa acgtgacacc aagtgccagt cacagggctc tgtaggagaa     2880

gagaagagca cctcaacgct caggggtggg gaggttcccg acagaaaaag gcccgagtct     2940

gtctactcta cttcaaagga caccaagtac cagtcggtgt atgttctatc tgcagaaaag     3000

gatgagtgtg ttatagcgac tgaggttgtg agcaagggcg aggaggataa catggccatc     3060

atcaaggagt tcatgcgctt caaggtgcac atggagggct ccgtgaacgg ccacgagttc     3120

gagatcgagg gcgagggcga gggccgcccc tacgagggca cccagaccgc caagctgaag     3180

gtgaccaagg gtggccccct gcccttcgcc tgggacatcc tgtcccctca gttcatgtac     3240

ggctccaagg cctacgtgaa gcaccccgcc gacatccccg actacttgaa gctgtccttc     3300

cccgagggct tcaagtggga gcgcgtgatg aacttcgagg acggcggcgt ggtgaccgtg     3360

acccaggact cctccctgca ggacggcgag ttcatctaca aggtgaagct gcgcggcacc     3420

aacttcccct ccgacggccc cgtaatgcag aagaagacca tgggctggga ggcctcctcc     3480

gagcggatgt accccgagga cggcgccctg aagggcgaga tcaagcagag gctgaagctg     3540

aaggacggcg gccactacga cgctgaggtc aagaccacct acaaggccaa gaagcccgtg     3600

cagctgcccg gcgcctacaa cgtcaacatc aagttggaca tcacctccca caacgaggac     3660

tacaccatcg tggaacagta cgaacgcgcc gagggccgcc actccaccgg cggcatggac     3720

gagctgtaca agtct                                                      3735


<210> 66
<211> 7677
<212> DNA
<213> Homo sapiens

<400> 66
atgccgccgc tcctggcgcc cctgctctgc ctggcgctgc tgcccgcgct cgccgcacga       60

ggcccgcgat gctcccagcc cggtgagacc tgcctgaatg gcgggaagtg tgaagcggcc      120

aatggcacgg aggcctgcgt ctgtggcggg gccttcgtgg gcccgcgatg ccaggacccc      180

aacccgtgcc tcagcacccc ctgcaagaac gccgggacat gccacgtggt ggaccgcaga      240

ggcgtggcag actatgcctg cagctgtgcc ctgggcttct ctgggcccct ctgcctgaca      300

cccctggaca atgcctgcct caccaacccc tgccgcaacg ggggcacctg cgacctgctc      360

acgctgacgg agtacaagtg ccgctgcccg cccggctggt cagggaaatc gtgccagcag      420

gctgacccgt gcgcctccaa cccctgcgcc aacggtggcc agtgcctgcc cttcgaggcc      480

tcctacatct gccactgccc acccagcttc catggcccca cctgccggca ggatgtcaac      540

gagtgtggcc agaagcccgg gctttgccgc cacggaggca cctgccacaa cgaggtcggc      600

tcctaccgct gcgtctgccg cgccacccac actggcccca actgcgagcg gccctacgtg      660

ccctgcagcc cctcgccctg ccagaacggg ggcacctgcc gccccacggg cgacgtcacc      720

cacgagtgtg cctgcctgcc aggcttcacc ggccagaact gtgaggaaaa tatcgacgat      780

tgtccaggaa acaactgcaa gaacgggggt gcctgtgtgg acggcgtgaa cacctacaac      840

tgccgctgcc cgccagagtg gacaggtcag tactgtaccg aggatgtgga cgagtgccag      900

ctgatgccaa atgcctgcca gaacggcggg acctgccaca acacccacgg tggctacaac      960

tgcgtgtgtg tcaacggctg gactggtgag gactgcagcg agaacattga tgactgtgcc     1020

agcgccgcct gcttccacgg cgccacctgc catgaccgtg tggcctcctt ctactgcgag     1080

tgtccccatg gccgcacagg tctgctgtgc cacctcaacg acgcatgcat cagcaacccc     1140

tgtaacgagg gctccaactg cgacaccaac cctgtcaatg gcaaggccat ctgcacctgc     1200

ccctcggggt acacgggccc ggcctgcagc caggacgtgg atgagtgctc gctgggtgcc     1260

aacccctgcg agcatgcggg caagtgcatc aacacgctgg gctccttcga gtgccagtgt     1320

ctgcagggct acacgggccc ccgatgcgag atcgacgtca acgagtgcgt ctcgaacccg     1380

tgccagaacg acgccacctg cctggaccag attggggagt tccagtgcat ctgcatgccc     1440

ggctacgagg gtgtgcactg cgaggtcaac acagacgagt gtgccagcag cccctgcctg     1500

cacaatggcc gctgcctgga caagatcaat gagttccagt gcgagtgccc cacgggcttc     1560

actgggcatc tgtgccagta cgatgtggac gagtgtgcca gcaccccctg caagaatggt     1620

gccaagtgcc tggacggacc caacacttac acctgtgtgt gcacggaagg gtacacgggg     1680

acgcactgcg aggtggacat cgatgagtgc gaccccgacc cctgccacta cggctcctgc     1740

aaggacggcg tcgccacctt cacctgcctc tgccgcccag gctacacggg ccaccactgc     1800

gagaccaaca tcaacgagtg ctccagccag ccctgccgcc acgggggcac ctgccaggac     1860

cgcgacaacg cctacctctg cttctgcctg aaggggacca caggacccaa ctgcgagatc     1920

aacctggatg actgtgccag cagcccctgc gactcgggca cctgtctgga caagatcgat     1980

ggctacgagt gtgcctgtga gccgggctac acagggagca tgtgtaacat caacatcgat     2040

gagtgtgcgg gcaacccctg ccacaacggg ggcacctgcg aggacggcat caatggcttc     2100

acctgccgct gccccgaggg ctaccacgac cccacctgcc tgtctgaggt caatgagtgc     2160

aacagcaacc cctgcgtcca cggggcctgc cgggacagcc tcaacgggta caagtgcgac     2220

tgtgaccctg ggtggagtgg gaccaactgt gacatcaaca acaatgagtg tgaatccaac     2280

ccttgtgtca acggcggcac ctgcaaagac atgaccagtg gctacgtgtg cacctgccgg     2340

gagggcttca gcggtcccaa ctgccagacc aacatcaacg agtgtgcgtc caacccatgt     2400

ctgaaccagg gcacgtgtat tgacgacgtt gccgggtaca agtgcaactg cctgctgccc     2460

tacacaggtg ccacgtgtga ggtggtgctg gccccgtgtg cccccagccc ctgcagaaac     2520

ggcggggagt gcaggcaatc cgaggactat gagagcttct cctgtgtctg ccccacgggc     2580

tggcaagcag ggcagacctg tgaggtcgac atcaacgagt gcgttctgag cccgtgccgg     2640

cacggcgcat cctgccagaa cacccacggc ggctaccgct gccactgcca ggccggctac     2700

agtgggcgca actgcgagac cgacatcgac gactgccggc ccaacccgtg tcacaacggg     2760

ggctcctgca cagacggcat caacacggcc ttctgcgact gcctgcccgg cttccggggc     2820

actttctgtg aggaggacat caacgagtgt gccagtgacc cctgccgcaa cggggccaac     2880

tgcacggact gcgtggacag ctacacgtgc acctgccccg caggcttcag cgggatccac     2940

tgtgagaaca acacgcctga ctgcacagag agctcctgct tcaacggtgg cacctgcgtg     3000

gacggcatca actcgttcac ctgcctgtgt ccacccggct tcacgggcag ctactgccag     3060

cacgatgtca atgagtgcga ctcacagccc tgcctgcatg gcggcacctg tcaggacggc     3120

tgcggctcct acaggtgcac ctgcccccag ggctacactg gccccaactg ccagaacctt     3180

gtgcactggt gtgactcctc gccctgcaag aacggcggca aatgctggca gacccacacc     3240

cagtaccgct gcgagtgccc cagcggctgg accggccttt actgcgacgt gcccagcgtg     3300

tcctgtgagg tggctgcgca gcgacaaggt gttgacgttg cccgcctgtg ccagcatgga     3360

gggctctgtg tggacgcggg caacacgcac cactgccgct gccaggcggg ctacacaggc     3420

agctactgtg aggacctggt ggacgagtgc tcacccagcc cctgccagaa cggggccacc     3480

tgcacggact acctgggcgg ctactcctgc aagtgcgtgg ccggctacca cggggtgaac     3540

tgctctgagg agatcgacga gtgcctctcc cacccctgcc agaacggggg cacctgcctc     3600

gacctcccca acacctacaa gtgctcctgc ccacggggca ctcagggtgt gcactgtgag     3660

atcaacgtgg acgactgcaa tccccccgtt gaccccgtgt cccggagccc caagtgcttt     3720

aacaacggca cctgcgtgga ccaggtgggc ggctacagct gcacctgccc gccgggcttc     3780

gtgggtgagc gctgtgaggg ggatgtcaac gagtgcctgt ccaatccctg cgacgcccgt     3840

ggcacccaga actgcgtgca gcgcgtcaat gacttccact gcgagtgccg tgctggtcac     3900

accgggcgcc gctgcgagtc cgtcatcaat ggctgcaaag gcaagccctg caagaatggg     3960

ggcacctgcg ccgtggcctc caacaccgcc cgcgggttca tctgcaagtg ccctgcgggc     4020

ttcgagggcg ccacgtgtga gaatgacgct cgtacctgcg gcagcctgcg ctgcctcaac     4080

ggcggcacat gcatctccgg cccgcgcagc cccacctgcc tgtgcctggg ccccttcacg     4140

ggccccgaat gccagttccc ggccagcagc ccctgcctgg gcggcaaccc ctgctacaac     4200

caggggacct gtgagcccac atccgagagc cccttctacc gttgcctgtg ccccgccaaa     4260

ttcaacgggc tcttgtgcca catcctggac tacagcttcg ggggtggggc cgggcgcgac     4320

atccccccgc cgctgatcga ggaggcgtgc gagctgcccg agtgccagga ggacgcgggc     4380

aacaaggtct gcagcctgca gtgcaacaac cacgcgtgcg gctgggacgg cggtgactgc     4440

tccctcaact tcaatgaccc ctggaagaac tgcacgcagt ctctgcagtg ctggaagtac     4500

ttcagtgacg gccactgtga cagccagtgc aactcagccg gctgcctctt cgacggcttt     4560

gactgccagc gtgcggaagg ccagtgcaac cccctgtacg accagtactg caaggaccac     4620

ttcagcgacg ggcactgcga ccagggctgc aacagcgcgg agtgcgagtg ggacgggctg     4680

gactgtgcgg agcatgtacc cgagaggctg gcggccggca cgctggtggt ggtggtgctg     4740

atgccgccgg agcagctgcg caacagctcc ttccacttcc tgcgggagct cagccgcgtg     4800

ctgcacacca acgtggtctt caagcgtgac gcacacggcc agcagatgat cttcccctac     4860

tacggccgcg aggaggagct gcgcaagcac cccatcaagc gtgccgccga gggctgggcc     4920

gcacctgacg ccctgctggg ccaggtgaag gcctcgctgc tccctggtgg cagcgagggt     4980

gggcggcggc ggagggagct ggaccccatg gacgtccgcg gctccatcgt ctacctggag     5040

attgacaacc ggcagtgtgt gcaggcctcc tcgcagtgct tccagagtgc caccgacgtg     5100

gccgcattcc tgggagcgct cgcctcgctg ggcagcctca acatccccta caagatcgag     5160

gccgtgcaga gtgagaccgt ggagccgccc ccgccggcgc agctgcactt catgtacgtg     5220

gcggcggccg cctttgtgct tctgttcttc gtgggctgcg gggtgctgct gtcccgcaag     5280

cgccggcggc agcatggcca gctctggttc cctgagggct tcaaagtgtc tgaggccagc     5340

aagaagaagc ggcgggagcc cctcggcgag gactccgtgg gcctcaagcc cctgaagaac     5400

gcttcagacg gtgccctcat ggacgacaac cagaatgagt ggggggacga ggacctggag     5460

accaagaagt tccggttcga ggagcccgtg gttctgcctg acctggacga ccagacagac     5520

caccggcagt ggactcagca gcacctggat gccgctgacc tgcgcatgtc tgccatggcc     5580

cccacaccgc cccagggtga ggttgacgcc gactgcatgg acgtcaatgt ccgcgggcct     5640

gatggcttca ccccgctcat gatcgcctcc tgcagcgggg gcggcctgga gacgggcaac     5700

agcgaggaag aggaggacgc gccggccgtc atctccgact tcatctacca gggcgccagc     5760

ctgcacaacc agacagaccg cacgggcgag accgccttgc acctggccgc ccgctactca     5820

cgctctgatg ccgccaagcg cctgctggag gccagcgcag atgccaacat ccaggacaac     5880

atgggccgca ccccgctgca tgcggctgtg tctgccgacg cacaaggtgt cttccagatc     5940

ctgatccgga accgagccac agacctggat gcccgcatgc atgatggcac gacgccactg     6000

atcctggctg cccgcctggc cgtggagggc atgctggagg acctcatcaa ctcacacgcc     6060

gacgtcaacg ccgtagatga cctgggcaag tccgccctgc actgggccgc cgccgtgaac     6120

aatgtggatg ccgcagttgt gctcctgaag aacggggcta acaaagatat gcagaacaac     6180

agggaggaga cacccctgtt tctggccgcc cgggagggca gctacgagac cgccaaggtg     6240

ctgctggacc actttgccaa ccgggacatc acggatcata tggaccgcct gccgcgcgac     6300

atcgcacagg agcgcatgca tcacgacatc gtgaggctgc tggacgagta caacctggtg     6360

cgcagcccgc agctgcacgg agccccgctg gggggcacgc ccaccctgtc gcccccgctc     6420

tgctcgccca acggctacct gggcagcctc aagcccggcg tgcagggcaa gaaggtccgc     6480

aagcccagca gcaaaggcct ggcctgtgga agcaaggagg ccaaggacct caaggcacgg     6540

aggaagaagt cccaggacgg caagggctgc ctgctggaca gctccggcat gctctcgccc     6600

gtggactccc tggagtcacc ccatggctac ctgtcagacg tggcctcgcc gccactgctg     6660

ccctccccgt tccagcagtc tccgtccgtg cccctcaacc acctgcctgg gatgcccgac     6720

acccacctgg gcatcgggca cctgaacgtg gcggccaagc ccgagatggc ggcgctgggt     6780

gggggcggcc ggctggcctt tgagactggc ccacctcgtc tctcccacct gcctgtggcc     6840

tctggcacca gcaccgtcct gggctccagc agcggagggg ccctgaattt cactgtgggc     6900

gggtccacca gtttgaatgg tcaatgcgag tggctgtccc ggctgcagag cggcatggtg     6960

ccgaaccaat acaaccctct gcgggggagt gtggcaccag gccccctgag cacacaggcc     7020

ccctccctgc agcatggcat ggtaggcccg ctgcacagta gccttgctgc cagcgccctg     7080

tcccagatga tgagctacca gggcctgccc agcacccggc tggccaccca gcctcacctg     7140

gtgcagaccc agcaggtgca gccacaaaac ttacagatgc agcagcagaa cctgcagcca     7200

gcaaacatcc agcagcagca aagcctgcag ccgccaccac caccaccaca gccgcacctt     7260

ggcgtgagct cagcagccag cggccacctg ggccggagct tcctgagtgg agagccgagc     7320

caggcagacg tgcagccact gggccccagc agcctggcgg tgcacactat tctgccccag     7380

gagagccccg ccctgcccac gtcgctgcca tcctcgctgg tcccacccgt gaccgcagcc     7440

cagttcctga cgcccccctc gcagcacagc tactcctcgc ctgtggacaa cacccccagc     7500

caccagctac aggtgcctga gcaccccttc ctcaccccgt cccctgagtc ccctgaccag     7560

tggtccagct cgtccccgca ttccaacgtc tccgactggt ccgagggcgt ctccagccct     7620

cccaccagca tgcagtccca gatcgcccgc attccggagg ccttcaaggc tagctaa        7677


<210> 67
<211> 1584
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 67
gccaccatgg cattgcccgt gaccgccctg ctgctgccac tggccttgtt gctccacgcc       60

gcgcggccag aacagaagct gatcagcgag gaggatctga ccggtgtgag caagggcgag      120

gagctgttca ccggggtggt gcccatcctg gtcgagctgg acggcgacgt aaacggccac      180

aagttctccg tgcggggcga gggcgagggc gatgccacca acggcaagct gaccctgaag      240

ttcatcagca ccaccggcaa gctgcccgtg ccctggccca ccctcgtgac caccctgacc      300

tacggcgtgc agagcttctc ccgctacccc gaccacatga agcgccacga cttcttcaag      360

agcgccatgc ccgaaggcta cgtccaggag cgcaccatct ccttcaagga cgacggcacc      420

tacaagaccc gcgccgaggt gaagttcgag ggcgacaccc tggtgaaccg catcgagctg      480

aagggcatcg acttcaagga ggacggcaac atcctggggc acaagctgga gtacaacttc      540

aactcccaca acgtctatat caccgccgac aagcagaaga acggcatcaa ggccaacttc      600

aagatccgcc acaacgtgga ggacggctcc gtgcagctcg ccgaccacta ccagcagaac      660

acccccatcg gcgacggccc cgtgctgctg cccgacaacc actacctgtc cacccagtcc      720

aagctgtcca aagaccccaa cgagaagcgc gatcacatgg tccttctgga attcgtgacc      780

gccgccggga tcactcacgg catggacgag ctgtacaagg gatccccggt ggagcctccg      840

ctgccctcgc agctgcacct catgtacgtg gcagcggccg ccttcgtgct cctgttcttt      900

gtgggctgtg gggtgctgct gtcccgcaag cgccggcggg gctcgagcat gaagctgctg      960

agcagcatcg agcaggcctg tgacatctgc cggctgaaga aactgaagtg cagcaaagaa     1020

aagcccaagt gcgccaagtg cctgaagaac aactgggagt gccggtacag ccccaagacc     1080

aagagaagcc ccctgaccag agcccacctg accgaggtgg aaagccggct ggaaagactg     1140

gaacagctgt ttctgctgat cttcccacgc gaggacctgg acatgatcct gaagatggac     1200

agcctgcagg acatcaaggc cctgctgacc ggcctgttcg tgcaggacaa cgtgaacaag     1260

gacgccgtga ccgacagact ggccagcgtg gaaaccgaca tgcccctgac cctgcggcag     1320

cacagaatca gcgccaccag cagcagcgag gaaagcagca acaagggcca gcggcagctg     1380

acagtgtctg ctgctgcagg cggaagcgga ggctctggcg gatctgatgc cctggacgac     1440

ttcgacctgg atatgctggg cagcgacgcc ctggatgatt ttgatctgga catgctggga     1500

tctgacgctc tggacgattt cgatctcgac atgttgggat cagatgcact ggatgacttt     1560

gacctggaca tgctcggatc atga                                            1584


<210> 68
<211> 525
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 68
Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Thr 
            20                  25                  30          


Gly Val Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu 
        35                  40                  45              


Val Glu Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Arg Gly 
    50                  55                  60                  


Glu Gly Glu Gly Asp Ala Thr Asn Gly Lys Leu Thr Leu Lys Phe Ile 
65                  70                  75                  80  


Ser Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr 
                85                  90                  95      


Leu Thr Tyr Gly Val Gln Ser Phe Ser Arg Tyr Pro Asp His Met Lys 
            100                 105                 110         


Arg His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu 
        115                 120                 125             


Arg Thr Ile Ser Phe Lys Asp Asp Gly Thr Tyr Lys Thr Arg Ala Glu 
    130                 135                 140                 


Val Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly 
145                 150                 155                 160 


Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr 
                165                 170                 175     


Asn Phe Asn Ser His Asn Val Tyr Ile Thr Ala Asp Lys Gln Lys Asn 
            180                 185                 190         


Gly Ile Lys Ala Asn Phe Lys Ile Arg His Asn Val Glu Asp Gly Ser 
        195                 200                 205             


Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly 
    210                 215                 220                 


Pro Val Leu Leu Pro Asp Asn His Tyr Leu Ser Thr Gln Ser Lys Leu 
225                 230                 235                 240 


Ser Lys Asp Pro Asn Glu Lys Arg Asp His Met Val Leu Leu Glu Phe 
                245                 250                 255     


Val Thr Ala Ala Gly Ile Thr His Gly Met Asp Glu Leu Tyr Lys Gly 
            260                 265                 270         


Ser Pro Val Glu Pro Pro Leu Pro Ser Gln Leu His Leu Met Tyr Val 
        275                 280                 285             


Ala Ala Ala Ala Phe Val Leu Leu Phe Phe Val Gly Cys Gly Val Leu 
    290                 295                 300                 


Leu Ser Arg Lys Arg Arg Arg Gly Ser Ser Met Lys Leu Leu Ser Ser 
305                 310                 315                 320 


Ile Glu Gln Ala Cys Asp Ile Cys Arg Leu Lys Lys Leu Lys Cys Ser 
                325                 330                 335     


Lys Glu Lys Pro Lys Cys Ala Lys Cys Leu Lys Asn Asn Trp Glu Cys 
            340                 345                 350         


Arg Tyr Ser Pro Lys Thr Lys Arg Ser Pro Leu Thr Arg Ala His Leu 
        355                 360                 365             


Thr Glu Val Glu Ser Arg Leu Glu Arg Leu Glu Gln Leu Phe Leu Leu 
    370                 375                 380                 


Ile Phe Pro Arg Glu Asp Leu Asp Met Ile Leu Lys Met Asp Ser Leu 
385                 390                 395                 400 


Gln Asp Ile Lys Ala Leu Leu Thr Gly Leu Phe Val Gln Asp Asn Val 
                405                 410                 415     


Asn Lys Asp Ala Val Thr Asp Arg Leu Ala Ser Val Glu Thr Asp Met 
            420                 425                 430         


Pro Leu Thr Leu Arg Gln His Arg Ile Ser Ala Thr Ser Ser Ser Glu 
        435                 440                 445             


Glu Ser Ser Asn Lys Gly Gln Arg Gln Leu Thr Val Ser Ala Ala Ala 
    450                 455                 460                 


Gly Gly Ser Gly Gly Ser Gly Gly Ser Asp Ala Leu Asp Asp Phe Asp 
465                 470                 475                 480 


Leu Asp Met Leu Gly Ser Asp Ala Leu Asp Asp Phe Asp Leu Asp Met 
                485                 490                 495     


Leu Gly Ser Asp Ala Leu Asp Asp Phe Asp Leu Asp Met Leu Gly Ser 
            500                 505                 510         


Asp Ala Leu Asp Asp Phe Asp Leu Asp Met Leu Gly Ser 
        515                 520                 525 


<210> 69
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      6xHis tag

<400> 69
His His His His His His 
1               5       


<210> 70
<211> 52
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 70
Val Gln Ser Glu Thr Val Glu Pro Pro Pro Pro Ala Gln Leu His Phe 
1               5                   10                  15      


Met Tyr Val Ala Ala Ala Ala Phe Val Leu Leu Phe Phe Val Gly Cys 
            20                  25                  30          


Gly Val Leu Leu Ser Arg Lys Arg Arg Arg Gln His Gly Gln Leu Trp 
        35                  40                  45              


Phe Pro Glu Gly 
    50          


