                               SEQUENCE LISTING

<110> OKLAHOMA MEDICAL RESEARCH FOUNDATION
 
<120> BISPECIFIC ANTIBODIES FOR THE TREATMENT OF STREPTOCOCCUS 
      PNEUMONIA

<130> 110867-0201

<140> PCT/US2018/035170
<141> 2018-05-30

<150> 62/513,124
<151> 2017-05-31

<160> 80    

<170> PatentIn version 3.5

<210> 1
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 1
Phe Ser Phe Ser Asn Asn Tyr Trp 
1               5               


<210> 2
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 2
Ile Lys Gln Asp Gly Ser Glu Lys 
1               5               


<210> 3
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 3
Ala Arg Glu Phe Val Gly Ser Tyr Asp Tyr 
1               5                   10  


<210> 4
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 4
Ser Ser Asp Val Gly Asp Tyr Asn Tyr 
1               5                   


<210> 5
<211> 3
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 5
Glu Val Thr 
1           


<210> 6
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 6
Tyr Ser His Arg Arg Lys Val 
1               5           


<210> 7
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 7
Gly Leu Thr Phe Ser Ser His Trp 
1               5               


<210> 8
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 8
Ile Lys Glu Asp Gly Ser Glu Lys 
1               5               


<210> 9
<211> 20
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 9
Ala Ser Arg Arg Cys Ser Thr Gly Val Cys Tyr Arg Tyr Ser His Tyr 
1               5                   10                  15      


Tyr Met Asp Asp 
            20  


<210> 10
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 10
Ser Gly Asp Val Gly Gly Tyr Asn Phe 
1               5                   


<210> 11
<211> 3
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 11
Asp Val Asn 
1           


<210> 12
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 12
Cys Ser Tyr Ala Gly Ile Tyr Thr Leu Val 
1               5                   10  


<210> 13
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 13
Gly Phe Ala Ile Ser Gly Asn Tyr 
1               5               


<210> 14
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 14
Ile Tyr Trp Thr Asp Asp Thr 
1               5           


<210> 15
<211> 13
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 15
Ala Arg Glu Leu Gly Val Phe His Ser Gly Gly Asp Gln 
1               5                   10              


<210> 16
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 16
Gln Ser Val Asn Ser Phe 
1               5       


<210> 17
<211> 3
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 17
Ala Ala Ser 
1           


<210> 18
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 18
His Gln Tyr Lys Asn Trp Pro Pro Met Gly Thr 
1               5                   10      


<210> 19
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 19
Gly Tyr Ser Phe Thr Ser Asn Tyr 
1               5               


<210> 20
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 20
Val Tyr Pro Asn Asp Gly Thr Thr 
1               5               


<210> 21
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 21
Ala Arg Asp Asp Ser Ala Phe Asp Tyr 
1               5                   


<210> 22
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 22
Gln Ser Leu Val His Ser Asp Gly Asn Thr Tyr 
1               5                   10      


<210> 23
<211> 3
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 23
Lys Ile Ser 
1           


<210> 24
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 24
Met Gln Ala Ser Gln Ser Thr Trp Thr 
1               5                   


<210> 25
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 25
Gly Phe Thr Phe Ser Ser Tyr Trp 
1               5               


<210> 26
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 26
Ile Lys Glu Asp Gly Ser Glu Lys 
1               5               


<210> 27
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 27
Ala Arg Gly Gln Ser Tyr Pro Gly Ile 
1               5                   


<210> 28
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 28
Gln Ser Val Ser Gly Asp 
1               5       


<210> 29
<211> 3
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 29
Gly Ala Thr 
1           


<210> 30
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 30
Gln Gln Tyr Asn Asn Trp Pro Arg Thr 
1               5                   


<210> 31
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 31
Gly Val Asn Phe Asn Ile Ala Trp 
1               5               


<210> 32
<211> 4
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 32
Ile Lys Ser Lys 
1               


<210> 33
<211> 13
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 33
Thr Thr Val Arg Asn Met Ala Asp Leu Ser Leu Asn His 
1               5                   10              


<210> 34
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 34
Gln Ser Val Ser Ser Thr Tyr 
1               5           


<210> 35
<211> 3
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 35
Gly Ala Ser 
1           


<210> 36
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 36
Gln Gln Tyr Asp Asp Ser Arg Trp Thr 
1               5                   


<210> 37
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 37
Gly Phe Ile Phe Ser Arg Ser Asp 
1               5               


<210> 38
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 38
Ile Arg Ala Ala Gly Val Glu Thr 
1               5               


<210> 39
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 39
Thr Arg Gly Ile Arg Asp Ile Ser Tyr 
1               5                   


<210> 40
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 40
Gln Ser Leu Val Tyr Ser Asp Gly Asn Thr Tyr 
1               5                   10      


<210> 41
<211> 3
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 41
Arg Val Ser 
1           


<210> 42
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 42
Ala Gln Gly Ala His Trp Pro Leu Thr 
1               5                   


<210> 43
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 43
Gly Tyr Met Phe Thr Ser Tyr Thr 
1               5               


<210> 44
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 44
Ile Gly Ala Gly Asp Gly Asn Ile 
1               5               


<210> 45
<211> 13
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 45
Ala Arg Glu Gly Thr Glu Val Gly Leu Asp Ile Asp Tyr 
1               5                   10              


<210> 46
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 46
Ser Ser Ser Asp Val Gly Ser Tyr Asn Gly 
1               5                   10  


<210> 47
<211> 3
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 47
Glu Val Thr 
1           


<210> 48
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 48
Ser Ser Tyr Thr Ser Ser Asn Thr Tyr Val 
1               5                   10  


<210> 49
<211> 117
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 49
Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser 
1               5                   10                  15      


Leu Arg Val Ser Cys Ala Ala Ser Gly Phe Ser Phe Ser Asn Asn Tyr 
            20                  25                  30          


Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Asn Ile Lys Gln Asp Gly Ser Glu Lys Tyr Tyr Val Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Val Ser Arg Asp Asn Ala Lys Asn Ala Leu His 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Val Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Phe Val Gly Ser Tyr Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210> 50
<211> 107
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 50
Gln Ser Ala Leu Thr Gln Pro Arg Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Asp Tyr 
            20                  25                  30          


Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Glu Val Thr Lys Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Tyr Ser His Arg Arg Lys 
                85                  90                  95      


Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105         


<210> 51
<211> 127
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 51
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Leu Thr Phe Ser Ser His 
            20                  25                  30          


Trp Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Pro Glu Trp Val 
        35                  40                  45              


Ala Asn Ile Lys Glu Asp Gly Ser Glu Lys Asn Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Glu Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Leu Asn Ser Leu Ser Ala Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Arg Arg Cys Ser Thr Gly Val Cys Tyr Arg Tyr Ser His Tyr 
            100                 105                 110         


Tyr Met Asp Asp Trp Gly Lys Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 125         


<210> 52
<211> 110
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 52
Gln Ser Ala Leu Thr Gln Pro Arg Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Val Ala Ile Ser Cys Thr Gly Thr Ser Gly Asp Val Gly Gly Tyr 
            20                  25                  30          


Asn Phe Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Phe Asp Val Asn Arg Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Met Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln His Glu Asp Glu Ala Asp Tyr Tyr Cys Cys Ser Tyr Ala Gly Ile 
                85                  90                  95      


Tyr Thr Leu Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110 


<210> 53
<211> 126
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 53
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ala Ile Ser Gly Asn 
            20                  25                  30          


Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Leu Ile Tyr Trp Thr Asp Asp Thr Val Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Val Ser Lys Asn Met Val His Leu 
65                  70                  75                  80  


Gln Met Ser Ser Leu Arg Val Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Glu Leu Gly Val Phe His Ser Gly Gly Asp Gln Trp Leu Gly Pro 
            100                 105                 110         


Leu Asp Cys Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125     


<210> 54
<211> 109
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 54
Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly 
1               5                   10                  15      


Glu Thr Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Asn Ser Phe 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Thr Arg Ala Thr Gly Val Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Ser 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys His Gln Tyr Lys Asn Trp Pro Pro 
                85                  90                  95      


Met Gly Thr Phe Gly Pro Gly Thr Lys Val Asp Ile Lys 
            100                 105                 


<210> 55
<211> 116
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 55
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Thr Ser Gly Tyr Ser Phe Thr Ser Asn 
            20                  25                  30          


Tyr Leu His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Met Val Tyr Pro Asn Asp Gly Thr Thr Thr Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Ser Glu Thr Ser Thr Thr Thr Ile Tyr 
65                  70                  75                  80  


Met Asp Leu Ser Gly Leu Thr Ser Glu Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Asp Ser Ala Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210> 56
<211> 112
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 56
Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Thr Leu Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Ile Ser Ser Gln Ser Leu Val His Ser 
            20                  25                  30          


Asp Gly Asn Thr Tyr Leu Ser Trp Leu Gln Gln Arg Pro Gly Gln Pro 
        35                  40                  45              


Pro Arg Leu Leu Ile Tyr Lys Ile Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ala Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Ala 
                85                  90                  95      


Ser Gln Ser Thr Trp Thr Leu Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210> 57
<211> 116
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 57
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Lys Ile Lys Glu Asp Gly Ser Glu Lys Tyr Tyr Val Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Ala Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Ser 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gln Ser Tyr Pro Gly Ile Trp Gly Gln Gly Thr Met Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210> 58
<211> 107
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 58
Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Gly Asp 
            20                  25                  30          


Leu Val Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Gly Ala Thr Thr Arg Ala Ser Gly Val Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Ser 
65                  70                  75                  80  


Glu Asp Phe Ala Ile Tyr Tyr Cys Gln Gln Tyr Asn Asn Trp Pro Arg 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210> 59
<211> 122
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 59
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Thr Ser Gly Val Asn Phe Asn Ile Ala 
            20                  25                  30          


Trp Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Arg Ile Lys Ser Lys Ile Gly Gly Gly Thr Thr Asp Tyr Ala Ala 
    50                  55                  60                  


Pro Val Lys Gly Arg Phe Thr Met Ser Ile Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Thr Thr Val Arg Asn Met Ala Asp Leu Ser Leu Asn His Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210> 60
<211> 108
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 60
Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Thr 
            20                  25                  30          


Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Thr Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Ala Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Asp Asp Ser Arg 
                85                  90                  95      


Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105             


<210> 61
<211> 116
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 61
Glu Val Gln Leu Leu Glu Ser Gly Gly Asp Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ile Phe Ser Arg Ser 
            20                  25                  30          


Asp Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Arg Ala Ala Gly Val Glu Thr Phe Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Phe Lys Asn Thr Leu His 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Phe Tyr Cys 
                85                  90                  95      


Thr Arg Gly Ile Arg Asp Ile Ser Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210> 62
<211> 112
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 62
Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Ser Ser Ser Gln Ser Leu Val Tyr Ser 
            20                  25                  30          


Asp Gly Asn Thr Tyr Leu Asn Trp Phe Gln Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Arg Arg Leu Ile Tyr Arg Val Ser Asn Arg Asp Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Tyr Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Ile Tyr Tyr Cys Ala Gln Gly 
                85                  90                  95      


Ala His Trp Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210> 63
<211> 120
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 63
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Met Phe Thr Ser Tyr 
            20                  25                  30          


Thr Met His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Gly Ala Gly Asp Gly Asn Ile Lys Tyr Ser Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Ala Thr Ile Thr Arg Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Gly Thr Glu Val Gly Leu Asp Ile Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210> 64
<211> 110
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 64
Gln Ser Ala Leu Thr Gln Pro Pro Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asp Val Gly Ser Tyr 
            20                  25                  30          


Asn Gly Val Ser Trp Tyr Lys Gln Pro Pro Gly Thr Val Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Glu Val Thr Asn Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ala Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Leu Pro Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Thr Ser Ser 
                85                  90                  95      


Asn Thr Tyr Val Phe Gly Thr Gly Thr Thr Val Thr Val Leu 
            100                 105                 110 


<210> 65
<211> 352
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 65
gtgcagctgg tggagtctgg gggaggcttg gtccagcctg gggggtccct gagagtctcc       60

tgtgcagcct ctggattcag ttttagtaat aattattgga tgagctgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtggccaac ataaagcaag atggaagtga gaaatactat      180

gtggactctg tgaagggccg attcaccgtc tccagagaca acgccaagaa cgcactgcat      240

ctgcaaatga acagcctgag agtcgaggac acggccgtgt attactgtgc gagggaattc      300

gttggctctt atgactactg gggccaggga accctggtca ccgtctcctc ag              352


<210> 66
<211> 322
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 66
cagtctgccc tgactcagcc tcgctcagtg tccgggtctc ctggacagtc agtcaccatc       60

tcctgcactg gaaccagcag tgatgttggt gattataact atgtctcgtg gtaccaacag      120

cacccaggca aagcccccaa actcatgatt tatgaagtca ctaagcggcc ctcaggggtc      180

cctgatcgct tctctggctc caagtctggc aacacggcct ccctgaccat ctctgggctc      240

caggctgagg atgaggctga ttattactgc tattcacata ggcgaaaagt tttcggcgga      300

gggaccaagc tgaccgtcct ag                                               322


<210> 67
<211> 381
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 67
gaggtgcagc tggtggagtc gggggggggc ttggtccagc ctggggggtc cctgagactc       60

tcctgtgtag cctctggact cacttttagt agccactgga tgacctgggt ccgccaggct      120

ccagggaagg ggccggagtg ggtggccaac ataaaggaag atggaagcga gaagaactat      180

gcggactctg tgaagggccg attcaccatc tccagagaca acgccgagaa ctcattgtat      240

ctgcaactaa acagcctgag tgccgacgac acggccgtct attactgtgc gagccggcgt      300

tgtagtactg gcgtttgtta tagatactct cattattaca tggacgactg gggcaaaggg      360

accacggtca ccgtctcctc a                                                381


<210> 68
<211> 331
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 68
cagtctgccc tgactcagcc tcgctcagtg tccgggtctc ctggacagtc agtcgccatc       60

tcctgcactg gaaccagcgg tgatgttggt ggttataatt ttgtctcctg gtatcaacaa      120

cacccaggca aagcccccaa actcatgatt tttgatgtca ataggcggcc ctcaggggtc      180

cctgatcgat tctctggctc caagtctggc aacacggcct ccatgaccat ctctgggctc      240

cagcatgaag atgaggctga ctattactgc tgttcatatg caggcatcta cactttggta      300

ttcggcggag ggaccaagct gaccgtccta a                                     331


<210> 69
<211> 379
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 69
gaggtgcagc tggtggagtc tgggggaggc ttggtccagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cgccatcagt ggtaactaca tgagttgggt ccgccaggct      120

ccagggaagg gcctggagtg ggtctcactt atttattgga ctgatgacac agtctacgca      180

gactccgtga agggcagatt caccatctcc agggacgtct ccaagaacat ggtgcatctt      240

caaatgagca gcctgagagt cgaggacacg gctgtttatt actgtgcgag agaattaggt      300

gtttttcatt caggggggga ccagtggctg ggccctttag actgctgggg ccagggaacc      360

ctggtcaccg tctcctcag                                                   379


<210> 70
<211> 328
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 70
gaaatagtga tgacgcagtc tccagccacc ctgtctgtgt ctccagggga aacagccacc       60

ctctcctgca gggccagtca gagtgttaac agcttcttag cctggtacca gcagaaacct      120

ggccaggctc ccaggctcct catctatgct gcatccacca gggccactgg tgtcccagcc      180

aggttcagtg gcagtgggtc tgggacagag ttcactctca ccatcagcag cctgcagtct      240

gaagattttg cagtttacta ctgtcaccag tataaaaact ggcctccgat gggcactttc      300

ggccctggga ccaaagtgga tatcaaac                                         328


<210> 71
<211> 349
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 71
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaagctt       60

tcctgcaaga catctggata ctccttcacc agcaactatt tgcactgggt gcgacaggcc      120

cctggacaag gacttgagtg gatgggaatg gtctacccaa atgatggtac tacaacctac      180

gctcagaagt ttcagggcag agtcaccatg accagtgaga cgtccacaac cacaatctac      240

atggacctga gcggcctgac atctgaggac acggccatat attactgtgc tagagacgat      300

tcggcctttg actactgggg ccagggaacc ctggtcaccg tctcctcag                  349


<210> 72
<211> 337
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 72
gatattgtga tgacccagac tccactctcc ttacctgtca cccttggaca gccggcctcc       60

atctcctgca tatctagtca aagcctcgta cacagtgatg gaaacaccta cttgagttgg      120

cttcagcaga ggccaggcca gcctccaaga ctcctgattt ataagatttc taaccggttc      180

tctggggtcc cagacagatt cagtggcagt ggggcaggga cagatttcac actgaaaatc      240

agcagggtgg aagctgagga tgtcggggtt tattactgca tgcaagcttc acaatctacg      300

tggacgctcg gccaagggac caaggtggag atcaaac                               337


<210> 73
<211> 349
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 73
gaggtgcagc tggtggagtc tgggggaggc ttggtccagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttagt agctattgga tgagctgggt ccgccaggct      120

ccagggaagg gactggagtg ggtgggcaaa ataaaggaag acggaagtga gaaatactat      180

gtggactctg tgaagggccg attcgccatc tccagagaca acgccaagaa ctccctgtct      240

ctgcaaatga acagcctgag agccgaggac acggccgtgt attactgtgc gagaggtcaa      300

tcatatccgg gaatttgggg ccaagggaca atggtcaccg tctcttcag                  349


<210> 74
<211> 322
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 74
gaaatagtga tgacgcagtc tccagccacc ctgtctgtgt ctccagggga aagagccacc       60

ctctcctgca gggccagtca gagtgttagc ggcgacttag tctggtacca gcagaaacct      120

ggccaggctc ccaggctcct catctatggt gccaccacca gggcctctgg tgtcccagcc      180

aggttcagtg gcagtgggtc tgggacagag ttcactctca ccatcagcag cctgcagtct      240

gaagattttg caatttatta ctgtcagcag tataataact ggccccggac gttcggccaa      300

gggaccaagg tggaaatcaa ac                                               322


<210> 75
<211> 367
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 75
gaggtgcagc tggtggagtc cgggggaggc ttggtaaagc cgggggagtc ccttagactc       60

tcgtgtgcaa cctctggagt caacttcaac atcgcctgga tgacctgggt ccgccaggct      120

ccagggaagg gactggagtg ggttggccgt attaaaagca aaattggtgg tgggacaaca      180

gactatgctg cacccgtgaa aggcagattc accatgtcaa tagatgattc aaaaaatacc      240

ctatatctgc aaatgaacag cctgaaaacc gaggacacag ccgtgtatta ttgtaccaca      300

gtccgcaata tggccgactt gtcccttaat cactggggcc agggaaccct ggtcaccgtc      360

tcctcag                                                                367


<210> 76
<211> 325
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 76
gaaattgtgt tgacgcagtc tccaggcacc ctgtctttgt ctccagggga aagagccacc       60

ctctcctgca gggccagtca gagtgtcagc agcacctact taaactggta ccagcagaag      120

cctggccagg ctcccaggct cctcatctat ggtgcgtcca ccagggccac tggcatccca      180

gacaggttca gtggcagtgg gtctggggca gacttcactc taaccatcag cagactggag      240

cctgaagact ttgcagtgta ctactgtcag caatatgatg actcacggtg gacgttcggc      300

caagggacca aggtggaaat caaac                                            325


<210> 77
<211> 349
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 77
gaggtgcagc tgttggagtc tgggggagac ttggtacagc cgggggggtc cctgagactc       60

tcctgtgcag cctctggatt catctttagc aggtcagaca tgacctgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcaagt attagagctg ctggtgttga gacattctac      180

gcagactccg tgaagggccg gttcaccata tccagagaca atttcaagaa tacgttgcat      240

cttcaaatga atagcctgag agccgaggac acggccgtct tttactgcac gaggggtatc      300

cgtgacatta gctactgggg ccagggaacc ctggtcaccg tctcctcag                  349


<210> 78
<211> 337
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 78
gatgttgtga tgactcagtc tccactctcc ctgcccgtca cccttggaca gccggcctcc       60

atctcctgca gctctagtca aagcctcgta tacagtgatg gaaacaccta cttgaattgg      120

tttcaacaga ggccaggcca atctccaagg cgcctaattt atagggtttc taaccgggac      180

tctggggtcc cagacagatt cagcggcagt gggtcaggca cttatttcac actgaaaatc      240

agcagggtgg aggctgagga tgttgggatt tattactgcg cgcaaggtgc acactggcct      300

ctcactttcg gcggagggac caaggtggaa atcaaac                               337


<210> 79
<211> 361
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 79
caggtgcagc tggtgcagtc tggggccgag gtgaagaagc ctggggcctc agtcaaggtt       60

tcctgcaagg cttctggata catgttcact agctatacta tgcattgggt gcgccaggcc      120

cccggacaaa ggcttgagtg gatgggatgg atcggcgccg gcgatggtaa cataaaatat      180

tcacagaagt tccagggcag agccaccatt accagggaca catccgcgag caccgcgtac      240

atggagctga gcagcctgag atctgaagac acggctatgt attactgtgc gagagagggt      300

acagaagtcg gtttggacat tgactactgg ggccagggaa ccctggtcac cgtctcctca      360

g                                                                      361


<210> 80
<211> 331
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 80
cagtctgccc tgactcagcc accctccgtg tccgggtctc ctggacagtc agtcaccatc       60

tcctgcactg gaagtagcag tgacgttgga agttataacg gtgtctcctg gtacaagcag      120

cccccaggca cagtccccaa actcatgatt tatgaggtca ctaatcggcc ctcaggggtc      180

cctgatcgct tctctggggc caagtctggc aacacggcct ccctgaccat ctctgggctc      240

ctgcctgagg acgaggctga ttattactgc agctcatata caagcagcaa cacttatgtc      300

ttcggaactg ggaccacggt caccgtccta g                                     331


