                         SEQUENCE LISTING

<110>  The Board of Regents of the University of Oklahoma
 
<120>  ANTI-DOUBLECORTIN-LIKE KINASE 1 ANTIBODIES AND METHODS OF USE

<130>  5835.181wo

<150>  62/512,372
<151>  2017-05-30

<160>  32    

<170>  PatentIn version 3.5

<210>  1
<211>  740
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Ser Phe Gly Arg Asp Met Glu Leu Glu His Phe Asp Glu Arg Asp 
1               5                   10                  15      


Lys Ala Gln Arg Tyr Ser Arg Gly Ser Arg Val Asn Gly Leu Pro Ser 
            20                  25                  30          


Pro Thr His Ser Ala His Cys Ser Phe Tyr Arg Thr Arg Thr Leu Gln 
        35                  40                  45              


Thr Leu Ser Ser Glu Lys Lys Ala Lys Lys Val Arg Phe Tyr Arg Asn 
    50                  55                  60                  


Gly Asp Arg Tyr Phe Lys Gly Ile Val Tyr Ala Ile Ser Pro Asp Arg 
65                  70                  75                  80  


Phe Arg Ser Phe Glu Ala Leu Leu Ala Asp Leu Thr Arg Thr Leu Ser 
                85                  90                  95      


Asp Asn Val Asn Leu Pro Gln Gly Val Arg Thr Ile Tyr Thr Ile Asp 
            100                 105                 110         


Gly Leu Lys Lys Ile Ser Ser Leu Asp Gln Leu Val Glu Gly Glu Ser 
        115                 120                 125             


Tyr Val Cys Gly Ser Ile Glu Pro Phe Lys Lys Leu Glu Tyr Thr Lys 
    130                 135                 140                 


Asn Val Asn Pro Asn Trp Ser Val Asn Val Lys Thr Thr Ser Ala Ser 
145                 150                 155                 160 


Arg Ala Val Ser Ser Leu Ala Thr Ala Lys Gly Ser Pro Ser Glu Val 
                165                 170                 175     


Arg Glu Asn Lys Asp Phe Ile Arg Pro Lys Leu Val Thr Ile Ile Arg 
            180                 185                 190         


Ser Gly Val Lys Pro Arg Lys Ala Val Arg Ile Leu Leu Asn Lys Lys 
        195                 200                 205             


Thr Ala His Ser Phe Glu Gln Val Leu Thr Asp Ile Thr Asp Ala Ile 
    210                 215                 220                 


Lys Leu Asp Ser Gly Val Val Lys Arg Leu Tyr Thr Leu Asp Gly Lys 
225                 230                 235                 240 


Gln Val Met Cys Leu Gln Asp Phe Phe Gly Asp Asp Asp Ile Phe Ile 
                245                 250                 255     


Ala Cys Gly Pro Glu Lys Phe Arg Tyr Gln Asp Asp Phe Leu Leu Asp 
            260                 265                 270         


Glu Ser Glu Cys Arg Val Val Lys Ser Thr Ser Tyr Thr Lys Ile Ala 
        275                 280                 285             


Ser Ser Ser Arg Arg Ser Thr Thr Lys Ser Pro Gly Pro Ser Arg Arg 
    290                 295                 300                 


Ser Lys Ser Pro Ala Ser Thr Ser Ser Val Asn Gly Thr Pro Gly Ser 
305                 310                 315                 320 


Gln Leu Ser Thr Pro Arg Ser Gly Lys Ser Pro Ser Pro Ser Pro Thr 
                325                 330                 335     


Ser Pro Gly Ser Leu Arg Lys Gln Arg Ser Ser Gln His Gly Gly Ser 
            340                 345                 350         


Ser Thr Ser Leu Ala Ser Thr Lys Val Cys Ser Ser Met Asp Glu Asn 
        355                 360                 365             


Asp Gly Pro Gly Glu Glu Val Ser Glu Glu Gly Phe Gln Ile Pro Ala 
    370                 375                 380                 


Thr Ile Thr Glu Arg Tyr Lys Val Gly Arg Thr Ile Gly Asp Gly Asn 
385                 390                 395                 400 


Phe Ala Val Val Lys Glu Cys Val Glu Arg Ser Thr Ala Arg Glu Tyr 
                405                 410                 415     


Ala Leu Lys Ile Ile Lys Lys Ser Lys Cys Arg Gly Lys Glu His Met 
            420                 425                 430         


Ile Gln Asn Glu Val Ser Ile Leu Arg Arg Val Lys His Pro Asn Ile 
        435                 440                 445             


Val Leu Leu Ile Glu Glu Met Asp Val Pro Thr Glu Leu Tyr Leu Val 
    450                 455                 460                 


Met Glu Leu Val Lys Gly Gly Asp Leu Phe Asp Ala Ile Thr Ser Thr 
465                 470                 475                 480 


Asn Lys Tyr Thr Glu Arg Asp Ala Ser Gly Met Leu Tyr Asn Leu Ala 
                485                 490                 495     


Ser Ala Ile Lys Tyr Leu His Ser Leu Asn Ile Val His Arg Asp Ile 
            500                 505                 510         


Lys Pro Glu Asn Leu Leu Val Tyr Glu His Gln Asp Gly Ser Lys Ser 
        515                 520                 525             


Leu Lys Leu Gly Asp Phe Gly Leu Ala Thr Ile Val Asp Gly Pro Leu 
    530                 535                 540                 


Tyr Thr Val Cys Gly Thr Pro Thr Tyr Val Ala Pro Glu Ile Ile Ala 
545                 550                 555                 560 


Glu Thr Gly Tyr Gly Leu Lys Val Asp Ile Trp Ala Ala Gly Val Ile 
                565                 570                 575     


Thr Tyr Ile Leu Leu Cys Gly Phe Pro Pro Phe Arg Gly Ser Gly Asp 
            580                 585                 590         


Asp Gln Glu Val Leu Phe Asp Gln Ile Leu Met Gly Gln Val Asp Phe 
        595                 600                 605             


Pro Ser Pro Tyr Trp Asp Asn Val Ser Asp Ser Ala Lys Glu Leu Ile 
    610                 615                 620                 


Thr Met Met Leu Leu Val Asp Val Asp Gln Arg Phe Ser Ala Val Gln 
625                 630                 635                 640 


Val Leu Glu His Pro Trp Val Asn Asp Asp Gly Leu Pro Glu Asn Glu 
                645                 650                 655     


His Gln Leu Ser Val Ala Gly Lys Ile Lys Lys His Phe Asn Thr Gly 
            660                 665                 670         


Pro Lys Pro Asn Ser Thr Ala Ala Gly Val Ser Val Ile Ala Thr Thr 
        675                 680                 685             


Ala Leu Asp Lys Glu Arg Gln Val Phe Arg Arg Arg Arg Asn Gln Asp 
    690                 695                 700                 


Val Arg Ser Arg Tyr Lys Ala Gln Pro Ala Pro Pro Glu Leu Asn Ser 
705                 710                 715                 720 


Glu Ser Glu Asp Tyr Ser Pro Ser Ser Ser Glu Thr Val Arg Ser Pro 
                725                 730                 735     


Asn Ser Pro Phe 
            740 


<210>  2
<211>  433
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Leu Glu Leu Ile Glu Val Asn Gly Thr Pro Gly Ser Gln Leu Ser 
1               5                   10                  15      


Thr Pro Arg Ser Gly Lys Ser Pro Ser Pro Ser Pro Thr Ser Pro Gly 
            20                  25                  30          


Ser Leu Arg Lys Gln Arg Ser Ser Gln His Gly Gly Ser Ser Thr Ser 
        35                  40                  45              


Leu Ala Ser Thr Lys Val Cys Ser Ser Met Asp Glu Asn Asp Gly Pro 
    50                  55                  60                  


Gly Glu Glu Val Ser Glu Glu Gly Phe Gln Ile Pro Ala Thr Ile Thr 
65                  70                  75                  80  


Glu Arg Tyr Lys Val Gly Arg Thr Ile Gly Asp Gly Asn Phe Ala Val 
                85                  90                  95      


Val Lys Glu Cys Val Glu Arg Ser Thr Ala Arg Glu Tyr Ala Leu Lys 
            100                 105                 110         


Ile Ile Lys Lys Ser Lys Cys Arg Gly Lys Glu His Met Ile Gln Asn 
        115                 120                 125             


Glu Val Ser Ile Leu Arg Arg Val Lys His Pro Asn Ile Val Leu Leu 
    130                 135                 140                 


Ile Glu Glu Met Asp Val Pro Thr Glu Leu Tyr Leu Val Met Glu Leu 
145                 150                 155                 160 


Val Lys Gly Gly Asp Leu Phe Asp Ala Ile Thr Ser Thr Asn Lys Tyr 
                165                 170                 175     


Thr Glu Arg Asp Ala Ser Gly Met Leu Tyr Asn Leu Ala Ser Ala Ile 
            180                 185                 190         


Lys Tyr Leu His Ser Leu Asn Ile Val His Arg Asp Ile Lys Pro Glu 
        195                 200                 205             


Asn Leu Leu Val Tyr Glu His Gln Asp Gly Ser Lys Ser Leu Lys Leu 
    210                 215                 220                 


Gly Asp Phe Gly Leu Ala Thr Ile Val Asp Gly Pro Leu Tyr Thr Val 
225                 230                 235                 240 


Cys Gly Thr Pro Thr Tyr Val Ala Pro Glu Ile Ile Ala Glu Thr Gly 
                245                 250                 255     


Tyr Gly Leu Lys Val Asp Ile Trp Ala Ala Gly Val Ile Thr Tyr Ile 
            260                 265                 270         


Leu Leu Cys Gly Phe Pro Pro Phe Arg Gly Ser Gly Asp Asp Gln Glu 
        275                 280                 285             


Val Leu Phe Asp Gln Ile Leu Met Gly Gln Val Asp Phe Pro Ser Pro 
    290                 295                 300                 


Tyr Trp Asp Asn Val Ser Asp Ser Ala Lys Glu Leu Ile Thr Met Met 
305                 310                 315                 320 


Leu Leu Val Asp Val Asp Gln Arg Phe Ser Ala Val Gln Val Leu Glu 
                325                 330                 335     


His Pro Trp Val Asn Asp Asp Gly Leu Pro Glu Asn Glu His Gln Leu 
            340                 345                 350         


Ser Val Ala Gly Lys Ile Lys Lys His Phe Asn Thr Gly Pro Lys Pro 
        355                 360                 365             


Asn Ser Thr Ala Ala Gly Val Ser Val Ile Ala Thr Thr Ala Leu Asp 
    370                 375                 380                 


Lys Glu Arg Gln Val Phe Arg Arg Arg Arg Asn Gln Asp Val Arg Ser 
385                 390                 395                 400 


Arg Tyr Lys Ala Gln Pro Ala Pro Pro Glu Leu Asn Ser Glu Ser Glu 
                405                 410                 415     


Asp Tyr Ser Pro Ser Ser Ser Glu Thr Val Arg Ser Pro Asn Ser Pro 
            420                 425                 430         


Phe 
    


<210>  3
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  3

Arg Arg Arg Asn Gln Asp Val Arg Ser Arg Tyr Lys Ala Gln 
1               5                   10                  


<210>  4
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  4

Glu Leu Asn Ser Glu Ser Glu Asp Tyr Ser Pro Ser 
1               5                   10          


<210>  5
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  5

Asp Val Arg Ser Arg Tyr Lys Ala Gln Pro Ala 
1               5                   10      


<210>  6
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  6

Pro Glu Leu Asn Ser Glu Ser Glu Asp Tyr Ser Pro Ser Ser Ser 
1               5                   10                  15  


<210>  7
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  7

Arg Ser Arg Tyr Lys Ala Gln Pro Ala Pro Pro Glu Leu Asn Ser 
1               5                   10                  15  


<210>  8
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  8

Asp Val Arg Ser Arg Tyr Lys Ala Gln Pro Ala Pro Pro Glu 
1               5                   10                  


<210>  9
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  9

Arg Tyr Lys Ala Gln Pro Ala Pro Pro Glu Leu Asn Ser Glu Ser 
1               5                   10                  15  


<210>  10
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  10

Asp Tyr Ser Pro Ser Ser Ser Glu Thr Val Arg Ser Pro Asn Ser Pro 
1               5                   10                  15      


Phe 
    


<210>  11
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  11

Glu Asp Tyr Ser Pro Ser Ser Ser Glu Thr Val Arg Ser Pro Asn 
1               5                   10                  15  


<210>  12
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  12

Glu Ser Glu Asp Tyr Ser Pro Ser Ser Ser Glu Thr Val Arg 
1               5                   10                  


<210>  13
<211>  357
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic nucleotide; HC variable cDNA sequence of CBT-15A

<400>  13
gacgtgaagc tcgtggagtc tgggggaggc ttagtgaagc ttggagggtc cctgaaactc       60

tcctgtgcag cctctggatt cactttcagt agctattaca tgtcttgggt tcgccagact      120

ccagagaaga ggctggagtt ggtcgcagcc attaatagta atggtggtag cacctactat      180

ccagacactg tgaagggccg attcaccatc tccagagaca atgccaagaa caccctgtac      240

ctgcaaatga gcagtctgaa gtctgaggac acagccttgt attactgtgc aagacatggg      300

ggtaactact ggtacttcga tgtctggggc gcagggacca cggtcaccgt ctcctca         357


<210>  14
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide; HC variable AA sequence of CBT-15A

<400>  14

Asp Val Lys Leu Val Glu Ser Gly Gly Gly Leu Val Lys Leu Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Tyr Met Ser Trp Val Arg Gln Thr Pro Glu Lys Arg Leu Glu Leu Val 
        35                  40                  45              


Ala Ala Ile Asn Ser Asn Gly Gly Ser Thr Tyr Tyr Pro Asp Thr Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Lys Ser Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Arg His Gly Gly Asn Tyr Trp Tyr Phe Asp Val Trp Gly Ala Gly 
            100                 105                 110         


Thr Thr Val Thr Val Ser Ser 
        115                 


<210>  15
<211>  339
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic nucleotide; LC variable cDNA sequence of CBT-15A

<400>  15
gacattgtga tgtcacagtc tccatcctcc ctagctgtgt cagttggaga gaaggttact       60

atgagctgca agtccagtca gagcctttta tatagtagca atcaaaagaa ctacttggcc      120

tggtaccagc agaaaccagg gcagtctcct aaactgctga tttactgggc atccactagg      180

gaatctgggg tccctgatcg cttcacaggc agtggatctg ggacagattt cactctcacc      240

atcagcagtg tgaaggctga agacctggca gtttattact gtcagcaata ttatagctat      300

ccgtacacgt tcggaggggg gaccaagctg gaaataaaa                             339


<210>  16
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide; LC variable AA sequence of CBT-15A

<400>  16

Asp Ile Val Met Ser Gln Ser Pro Ser Ser Leu Ala Val Ser Val Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser Leu Leu Tyr Ser 
            20                  25                  30          


Ser Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Lys Ala Glu Asp Leu Ala Val Tyr Tyr Cys Gln Gln 
                85                  90                  95      


Tyr Tyr Ser Tyr Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Lys 
    


<210>  17
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide; VH CDR1 of CBT-15A

<400>  17

Gly Phe Thr Phe Ser Ser Tyr Tyr 
1               5               


<210>  18
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide; VH CDR2 of CBT-15A

<400>  18

Ile Asn Ser Asn Gly Gly Ser Thr 
1               5               


<210>  19
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide; VH CDR3 of CBT-15A

<400>  19

Ala Arg His Gly Gly Asn Tyr Trp Tyr Phe Asp Val 
1               5                   10          


<210>  20
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide; VL CDR1 of CBT-15A

<400>  20

Gln Ser Leu Leu Tyr Ser Ser Asn Gln Lys Asn Tyr 
1               5                   10          


<210>  21
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide; VL CDR2 of CBT-15A

<400>  21

Trp Ala Ser 
1           


<210>  22
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide; VL CDR3 of CBT-15A

<400>  22

Gln Gln Tyr Tyr Ser Tyr Pro Tyr Thr 
1               5                   


<210>  23
<211>  351
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic nucleotide; HC variable cDNA sequence of CBT-15G

<400>  23
gaggtccagc tgcagcagtc tgggactgcg ctggcaaggc ctggggcttc cgtgaagatg       60

tcctgcaagg cttctggcta cagctttacc agctactgga tgcactgggt aaaacagagg      120

cctggacagg gtctagaatg gattggtgct atttatcctg gaaaaagtga tactagctac      180

aaccagaagt tcaagggcaa ggccaaactg actgcagtca catccgccag cactgcctac      240

atggagctca gcagcctgac aaatgaggac tctgcggtct attactgtac aagatatggt      300

aagggtgcta tggactactg gggtcaagga acctcagtca ccgtctcctc a               351


<210>  24
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide; HC variable AA sequence of CBT-15G

<400>  24

Glu Val Gln Leu Gln Gln Ser Gly Thr Ala Leu Ala Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Ser Tyr 
            20                  25                  30          


Trp Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ala Ile Tyr Pro Gly Lys Ser Asp Thr Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Lys Leu Thr Ala Val Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Thr Asn Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Tyr Gly Lys Gly Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  25
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic nucleotide; LC variable cDNA sequence of CBT-15G

<400>  25
gacattgtgc tgacccaatc tcacaaattc atgtccacat cagtaggaga cagggtcacc       60

atcacctgca aggccagtca ggatgtgaat actgctgtag cctggtatca aaaaaaacca      120

gggcaatctc ctaaactgct gatttactgg gcatccaccc ggctcactgg agtccctgat      180

cgcttcacag gcagtggatc tgggacagat tatactctca ccatcagcag tgtgcaggct      240

gaagacctgg cactttatta ctgtcagcaa cattatagta ctccgtacac gttcggaggg      300

gggaccaagc tggaaataaa a                                                321


<210>  26
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide; LC variable AA sequence of CBT-15G

<400>  26

Asp Ile Val Leu Thr Gln Ser His Lys Phe Met Ser Thr Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Val Asn Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Lys Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Trp Ala Ser Thr Arg Leu Thr Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Val Gln Ala 
65                  70                  75                  80  


Glu Asp Leu Ala Leu Tyr Tyr Cys Gln Gln His Tyr Ser Thr Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  27
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide; VH CDR1 of CBT-15G

<400>  27

Ser Tyr Trp Met His 
1               5   


<210>  28
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide; VH CDR2 of CBT-15G

<400>  28

Ala Ile Tyr Pro Gly Lys Ser Asp Thr Ser Tyr Asn Gln Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  29
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide; VH CDR3 of CBT-15G

<400>  29

Tyr Gly Lys Gly Ala Met Asp Tyr 
1               5               


<210>  30
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide; VL CDR1 of CBT-15G

<400>  30

Lys Ala Ser Gln Asp Val Asn Thr Ala Val Ala 
1               5                   10      


<210>  31
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide; VL CDR2 of CBT-15G

<400>  31

Trp Ala Ser Thr Arg Leu Thr 
1               5           


<210>  32
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide; VL CDR3 of CBT-15G

<400>  32

Gln Gln His Tyr Ser Thr Pro Tyr Thr 
1               5                   


