                         SEQUENCE LISTING

<110>  ORGENESIS LTD
       TEL HASHOMER MEDICAL RESEARCH INFRASTRUCTURE AND SERVICES 
       LTD.
       FERBER, Sarah
       GREENBERGER, Shoshana
       MEIVAR-LEVY, Irit
 
<120>  VASCULAR SECRETOME, METHODS OF MAKING SAME, AND METHODS OF USE 
       THEREOF

<130>  P-570840-PC

<150>  62/512,085
<151>  2017-05-29

<150>  62/512,083
<151>  2017-05-29

<160>  22    

<170>  PatentIn version 3.5

<210>  1
<211>  283
<212>  PRT
<213>  Homo sapiens - PDX-1

<400>  1

Met Asn Gly Glu Glu Gln Tyr Tyr Ala Ala Thr Gln Leu Tyr Lys Asp 
1               5                   10                  15      


Pro Cys Ala Phe Gln Arg Gly Pro Ala Pro Glu Phe Ser Ala Ser Pro 
            20                  25                  30          


Pro Ala Cys Leu Tyr Met Gly Arg Gln Pro Pro Pro Pro Pro Pro His 
        35                  40                  45              


Pro Phe Pro Gly Ala Leu Gly Ala Leu Glu Gln Gly Ser Pro Pro Asp 
    50                  55                  60                  


Ile Ser Pro Tyr Glu Val Pro Pro Leu Ala Asp Asp Pro Ala Val Ala 
65                  70                  75                  80  


His Leu His His His Leu Pro Ala Gln Leu Ala Leu Pro His Pro Pro 
                85                  90                  95      


Ala Gly Pro Phe Pro Glu Gly Ala Glu Pro Gly Val Leu Glu Glu Pro 
            100                 105                 110         


Asn Arg Val Gln Leu Pro Phe Pro Trp Met Lys Ser Thr Lys Ala His 
        115                 120                 125             


Ala Trp Lys Gly Gln Trp Ala Gly Gly Ala Tyr Ala Ala Glu Pro Glu 
    130                 135                 140                 


Glu Asn Lys Arg Thr Arg Thr Ala Tyr Thr Arg Ala Gln Leu Leu Glu 
145                 150                 155                 160 


Leu Glu Lys Glu Phe Leu Phe Asn Lys Tyr Ile Ser Arg Pro Arg Arg 
                165                 170                 175     


Val Glu Leu Ala Val Met Leu Asn Leu Thr Glu Arg His Ile Lys Ile 
            180                 185                 190         


Trp Phe Gln Asn Arg Arg Met Lys Trp Lys Lys Glu Glu Asp Lys Lys 
        195                 200                 205             


Arg Gly Gly Gly Thr Ala Val Gly Gly Gly Gly Val Ala Glu Pro Glu 
    210                 215                 220                 


Gln Asp Cys Ala Val Thr Ser Gly Glu Glu Leu Leu Ala Leu Pro Pro 
225                 230                 235                 240 


Pro Pro Pro Pro Gly Gly Ala Val Pro Pro Ala Ala Pro Val Ala Ala 
                245                 250                 255     


Arg Glu Gly Arg Leu Pro Pro Gly Leu Ser Ala Ser Pro Gln Pro Ser 
            260                 265                 270         


Ser Val Ala Pro Arg Arg Pro Gln Glu Pro Arg 
        275                 280             


<210>  2
<211>  852
<212>  DNA
<213>  Homo sapiens - PDX-1

<400>  2
atgaacggcg aggagcagta ctacgcggcc acgcagcttt acaaggaccc atgcgcgttc       60

cagcgaggcc cggcgccgga gttcagcgcc agcccccctg cgtgcctgta catgggccgc      120

cagcccccgc cgccgccgcc gcacccgttc cctggcgccc tgggcgcgct ggagcagggc      180

agccccccgg acatctcccc gtacgaggtg ccccccctcg ccgacgaccc cgcggtggcg      240

caccttcacc accacctccc ggctcagctc gcgctccccc acccgcccgc cgggcccttc      300

ccggagggag ccgagccggg cgtcctggag gagcccaacc gcgtccagct gcctttccca      360

tggatgaagt ctaccaaagc tcacgcgtgg aaaggccagt gggcaggcgg cgcctacgct      420

gcggagccgg aggagaacaa gcggacgcgc acggcctaca cgcgcgcaca gctgctagag      480

ctggagaagg agttcctatt caacaagtac atctcacggc cgcgccgggt ggagctggct      540

gtcatgttga acttgaccga gagacacatc aagatctggt tccaaaaccg ccgcatgaag      600

tggaaaaagg aggaggacaa gaagcgcggc ggcgggacag ctgtcggggg tggcggggtc      660

gcggagcctg agcaggactg cgccgtgacc tccggcgagg agcttctggc gctgccgccg      720

ccgccgcccc ccggaggtgc tgtgccgccc gctgcccccg ttgccgcccg agagggccgc      780

ctgccgcctg gccttagcgc gtcgccacag ccctccagcg tcgcgcctcg gcggccgcag      840

gaaccacgat ga                                                          852


<210>  3
<211>  353
<212>  PRT
<213>  Homo sapiens - MafA

<400>  3

Met Ala Ala Glu Leu Ala Met Gly Ala Glu Leu Pro Ser Ser Pro Leu 
1               5                   10                  15      


Ala Ile Glu Tyr Val Asn Asp Phe Asp Leu Met Lys Phe Glu Val Lys 
            20                  25                  30          


Lys Glu Pro Pro Glu Ala Glu Arg Phe Cys His Arg Leu Pro Pro Gly 
        35                  40                  45              


Ser Leu Ser Ser Thr Pro Leu Ser Thr Pro Cys Ser Ser Val Pro Ser 
    50                  55                  60                  


Ser Pro Ser Phe Cys Ala Pro Ser Pro Gly Thr Gly Gly Gly Gly Gly 
65                  70                  75                  80  


Ala Gly Gly Gly Gly Gly Ser Ser Gln Ala Gly Gly Ala Pro Gly Pro 
                85                  90                  95      


Pro Ser Gly Gly Pro Gly Ala Val Gly Gly Thr Ser Gly Lys Pro Ala 
            100                 105                 110         


Leu Glu Asp Leu Tyr Trp Met Ser Gly Tyr Gln His His Leu Asn Pro 
        115                 120                 125             


Glu Ala Leu Asn Leu Thr Pro Glu Asp Ala Val Glu Ala Leu Ile Gly 
    130                 135                 140                 


Ser Gly His His Gly Ala His His Gly Ala His His Pro Ala Ala Ala 
145                 150                 155                 160 


Ala Ala Tyr Glu Ala Phe Arg Gly Pro Gly Phe Ala Gly Gly Gly Gly 
                165                 170                 175     


Ala Asp Asp Met Gly Ala Gly His His His Gly Ala His His Ala Ala 
            180                 185                 190         


His His His His Ala Ala His His His His His His His His His His 
        195                 200                 205             


Gly Gly Ala Gly His Gly Gly Gly Ala Gly His His Val Arg Leu Glu 
    210                 215                 220                 


Glu Arg Phe Ser Asp Asp Gln Leu Val Ser Met Ser Val Arg Glu Leu 
225                 230                 235                 240 


Asn Arg Gln Leu Arg Gly Phe Ser Lys Glu Glu Val Ile Arg Leu Lys 
                245                 250                 255     


Gln Lys Arg Arg Thr Leu Lys Asn Arg Gly Tyr Ala Gln Ser Cys Arg 
            260                 265                 270         


Phe Lys Arg Val Gln Gln Arg His Ile Leu Glu Ser Glu Lys Cys Gln 
        275                 280                 285             


Leu Gln Ser Gln Val Glu Gln Leu Lys Leu Glu Val Gly Arg Leu Ala 
    290                 295                 300                 


Lys Glu Arg Asp Leu Tyr Lys Glu Lys Tyr Glu Lys Leu Ala Gly Arg 
305                 310                 315                 320 


Gly Gly Pro Gly Ser Ala Gly Gly Ala Gly Phe Pro Arg Glu Pro Ser 
                325                 330                 335     


Pro Pro Gln Ala Gly Pro Gly Gly Ala Lys Gly Thr Ala Asp Phe Phe 
            340                 345                 350         


Leu 
    


<210>  4
<211>  1059
<212>  DNA
<213>  Homo sapiens - MafA

<400>  4
atggccgcgg agctggcgat gggcgccgag ctgcccagca gcccgctggc catcgagtac       60

gtcaacgact tcgacctgat gaagttcgag gtgaagaagg agcctcccga ggccgagcgc      120

ttctgccacc gcctgccgcc aggctcgctg tcctcgacgc cgctcagcac gccctgctcc      180

tccgtgccct cctcgcccag cttctgcgcg cccagcccgg gcaccggcgg cggcggcggc      240

gcggggggcg gcggcggctc gtctcaggcc gggggcgccc ccgggccgcc gagcgggggc      300

cccggcgccg tcgggggcac ctcggggaag ccggcgctgg aggatctgta ctggatgagc      360

ggctaccagc atcacctcaa ccccgaggcg ctcaacctga cgcccgagga cgcggtggag      420

gcgctcatcg gcagcggcca ccacggcgcg caccacggcg cgcaccaccc ggcggccgcc      480

gcagcctacg aggctttccg cggcccgggc ttcgcgggcg gcggcggagc ggacgacatg      540

ggcgccggcc accaccacgg cgcgcaccac gccgcccacc accaccacgc cgcccaccac      600

caccaccacc accaccacca tggcggcgcg ggacacggcg gtggcgcggg ccaccacgtg      660

cgcctggagg agcgcttctc cgacgaccag ctggtgtcca tgtcggtgcg cgagctgaac      720

cggcagctcc gcggcttcag caaggaggag gtcatccggc tcaagcagaa gcggcgcacg      780

ctcaagaacc gcggctacgc gcagtcctgc cgcttcaagc gggtgcagca gcggcacatt      840

ctggagagcg agaagtgcca actccagagc caggtggagc agctgaagct ggaggtgggg      900

cgcctggcca aagagcggga cctgtacaag gagaaatacg agaagctggc gggccggggc      960

ggccccggga gcgcgggcgg ggccggtttc ccgcgggagc cttcgccgcc gcaggccggt     1020

cccggcgggg ccaagggcac ggccgacttc ttcctgtag                            1059


<210>  5
<211>  356
<212>  PRT
<213>  Homo sapiens - NeuroD1

<400>  5

Met Thr Lys Ser Tyr Ser Glu Ser Gly Leu Met Gly Glu Pro Gln Pro 
1               5                   10                  15      


Gln Gly Pro Pro Ser Trp Thr Asp Glu Cys Leu Ser Ser Gln Asp Glu 
            20                  25                  30          


Glu His Glu Ala Asp Lys Lys Glu Asp Asp Leu Glu Thr Met Asn Ala 
        35                  40                  45              


Glu Glu Asp Ser Leu Arg Asn Gly Gly Glu Glu Glu Asp Glu Asp Glu 
    50                  55                  60                  


Asp Leu Glu Glu Glu Glu Glu Glu Glu Glu Glu Asp Asp Asp Gln Lys 
65                  70                  75                  80  


Pro Lys Arg Arg Gly Pro Lys Lys Lys Lys Met Thr Lys Ala Arg Leu 
                85                  90                  95      


Glu Arg Phe Lys Leu Arg Arg Met Lys Ala Asn Ala Arg Glu Arg Asn 
            100                 105                 110         


Arg Met His Gly Leu Asn Ala Ala Leu Asp Asn Leu Arg Lys Val Val 
        115                 120                 125             


Pro Cys Tyr Ser Lys Thr Gln Lys Leu Ser Lys Ile Glu Thr Leu Arg 
    130                 135                 140                 


Leu Ala Lys Asn Tyr Ile Trp Ala Leu Ser Glu Ile Leu Arg Ser Gly 
145                 150                 155                 160 


Lys Ser Pro Asp Leu Val Ser Phe Val Gln Thr Leu Cys Lys Gly Leu 
                165                 170                 175     


Ser Gln Pro Thr Thr Asn Leu Val Ala Gly Cys Leu Gln Leu Asn Pro 
            180                 185                 190         


Arg Thr Phe Leu Pro Glu Gln Asn Gln Asp Met Pro Pro His Leu Pro 
        195                 200                 205             


Thr Ala Ser Ala Ser Phe Pro Val His Pro Tyr Ser Tyr Gln Ser Pro 
    210                 215                 220                 


Gly Leu Pro Ser Pro Pro Tyr Gly Thr Met Asp Ser Ser His Val Phe 
225                 230                 235                 240 


His Val Lys Pro Pro Pro His Ala Tyr Ser Ala Ala Leu Glu Pro Phe 
                245                 250                 255     


Phe Glu Ser Pro Leu Thr Asp Cys Thr Ser Pro Ser Phe Asp Gly Pro 
            260                 265                 270         


Leu Ser Pro Pro Leu Ser Ile Asn Gly Asn Phe Ser Phe Lys His Glu 
        275                 280                 285             


Pro Ser Ala Glu Phe Glu Lys Asn Tyr Ala Phe Thr Met His Tyr Pro 
    290                 295                 300                 


Ala Ala Thr Leu Ala Gly Ala Gln Ser His Gly Ser Ile Phe Ser Gly 
305                 310                 315                 320 


Thr Ala Ala Pro Arg Cys Glu Ile Pro Ile Asp Asn Ile Met Ser Phe 
                325                 330                 335     


Asp Ser His Ser His His Glu Arg Val Met Ser Ala Gln Leu Asn Ala 
            340                 345                 350         


Ile Phe His Asp 
        355     


<210>  6
<211>  1071
<212>  DNA
<213>  Homo sapiens - NeuroD1

<400>  6
atgaccaaat cgtacagcga gagtgggctg atgggcgagc ctcagcccca aggtcctcca       60

agctggacag acgagtgtct cagttctcag gacgaggagc acgaggcaga caagaaggag      120

gacgacctcg aagccatgaa cgcagaggag gactcactga ggaacggggg agaggaggag      180

gacgaagatg aggacctgga agaggaggaa gaagaggaag aggaggatga cgatcaaaag      240

cccaagagac gcggccccaa aaagaagaag atgactaagg ctcgcctgga gcgttttaaa      300

ttgagacgca tgaaggctaa cgcccgggag cggaaccgca tgcacggact gaacgcggcg      360

ctagacaacc tgcgcaaggt ggtgccttgc tattctaaga cgcagaagct gtccaaaatc      420

gagactctgc gcttggccaa gaactacatc tgggctctgt cggagatctc gcgctcaggc      480

aaaagcccag acctggtctc cttcgttcag acgctttgca agggcttatc ccaacccacc      540

accaacctgg ttgcgggctg cctgcaactc aatcctcgga cttttctgcc tgagcagaac      600

caggacatgc ccccgcacct gccgacggcc agcgcttcct tccctgtaca cccctactcc      660

taccagtcgc ctgggctgcc cagtccgcct tacggtacca tggacagctc ccatgtcttc      720

cacgttaagc ctccgccgca cgcctacagc gcagcgctgg agcccttctt tgaaagccct      780

ctgactgatt gcaccagccc ttcctttgat ggacccctca gcccgccgct cagcatcaat      840

ggcaacttct ctttcaaaca cgaaccgtcc gccgagtttg agaaaaatta tgcctttacc      900

atgcactatc ctgcagcgac actggcaggg gcccaaagcc acggatcaat cttctcaggc      960

accgctgccc ctcgctgcga gatccccata gacaatatta tgtccttcga tagccattca     1020

catcatgagc gagtcatgag tgcccagctc aatgccatat ttcatgatta g              1071


<210>  7
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ins Forward primer

<400>  7
gaagcgtggc attgtggaac                                                   20


<210>  8
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ins Reverse primer

<400>  8
gctgcgtcta gttgcagtag t                                                 21


<210>  9
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  GCG Forward primer

<400>  9
ccaagatttt gtgcagtggt                                                   20


<210>  10
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  GCG Reverse primer

<400>  10
ggtaaaggtc ccttcagcat                                                   20


<210>  11
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SST Forward primer

<400>  11
atgatgccct ggaacctgaa g                                                 21


<210>  12
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SST Reverse primer

<400>  12
gccgggtttg agttagcaga t                                                 21


<210>  13
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  NKX6.1 Forward primer

<400>  13
gggctcgttt ggcctattcg                                                   20


<210>  14
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  NKX6.1 Reverse primer

<400>  14
gtgcttcttc ctccacttgg t                                                 21


<210>  15
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PAX4 Forward primer

<400>  15
gggtctggtt ttccaacaga aa                                                22


<210>  16
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PAX4 Reverse primer

<400>  16
tcagcccctg ggaagca                                                      17


<210>  17
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SCG2 Forward primer

<400>  17
ggaggaatat gctgtggagc tc                                                22


<210>  18
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SCG2 Reverse primer

<400>  18
cagccccaga gatgaggaaa                                                   20


<210>  19
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  GLUT2 Forward primer

<400>  19
tccagctacc gacagcctat t                                                 21


<210>  20
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  GLUT2 Reverse primer

<400>  20
ccagccgtct gaaaaatgct                                                   20


<210>  21
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Bactin Forward primer

<400>  21
cctggacttc gagcaagaga                                                   20


<210>  22
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Bactin Reverse primer

<400>  22
cagcggaacc gctcattgcc aatgg                                             25


