                         SEQUENCE LISTING

<110>  Vilnius University       
       IKNYS, Virginijus
       KAZLAUSKIEN, Migl
       TAMULAITIS, Gintautas
       KOSTIUK, Georgij
 
<120>  PRODUCTION OF CYCLIC ADENYLATES AND THEIR USE AS ALLOSTERIC 
       REGULATORS

<130>  V83-53

<140>  62512868
<141>  2017-05-31

<160>  26    

<170>  PatentIn version 3.5

<210>  1
<211>  4
<212>  PRT
<213>  Streptococcus thermophilus

<400>  1

Gly Gly Asp Asp 
1               


<210>  2
<211>  10
<212>  PRT
<213>  Streptococcus thermophilus


<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (6)..(8)
<223>  Xaa can be any naturally occurring amino acid

<400>  2

Asp Asn Xaa Ser Thr Xaa Xaa Xaa Arg Lys 
1               5                   10  


<210>  3
<211>  190
<212>  PRT
<213>  Streptococcus thermophilus

<400>  3

Val Glu Asp Leu Asp Ala Leu Trp Glu Arg Tyr Arg Glu Ala Val Arg 
1               5                   10                  15      


Ala Gly Gly Asn Pro Gln Ala Leu Tyr Gln Glu Met Val Trp Pro Ala 
            20                  25                  30          


Leu Leu Ala Leu Trp Arg Glu Lys Pro Arg Val Tyr Pro Phe Pro Gln 
        35                  40                  45              


Ala Phe Ala Val Ser Val His Thr Leu Gly Thr Ser Pro Glu Ala Thr 
    50                  55                  60                  


Ala Leu Ala Ile Leu Gly Ala Gly Ala Glu Arg Val Tyr Val Leu His 
65                  70                  75                  80  


Thr Pro Glu Ser Ala Arg Phe Leu Pro Arg Leu Arg Gln Asp Thr Gly 
                85                  90                  95      


Lys Asp Leu Tyr Pro Val Glu Ile Gly Lys Ser Asp Val Glu Ala Ile 
            100                 105                 110         


Tyr Arg Glu Val Lys Arg Leu Leu Glu Lys His Pro Glu Val Pro Val 
        115                 120                 125             


Ala Leu Asp Leu Thr Ser Gly Thr Lys Ala Met Ser Ala Gly Leu Ala 
    130                 135                 140                 


Ala Ala Gly Phe Phe Phe Gln Arg Phe Tyr Pro Lys Val Arg Val Val 
145                 150                 155                 160 


Tyr Val Asp Asn Glu Asp Tyr Asp Pro Glu Leu Arg Arg Pro Arg Ala 
                165                 170                 175     


Gly Thr Glu Lys Leu Arg Ile Leu Pro Asn Pro His Glu Ala 
            180                 185                 190 


<210>  4
<211>  180
<212>  PRT
<213>  Streptococcus thermophilus

<400>  4

Met Lys Ile Leu Phe Ser Pro Ile Gly Asn Ser Asp Pro Trp Arg Asn 
1               5                   10                  15      


Asp Arg Asp Gly Ala Met Leu His Ile Val Arg His Tyr Asn Leu Asp 
            20                  25                  30          


Lys Val Val Leu Tyr Phe Thr Arg Thr Ile Trp Glu Gly Asn Glu Asn 
        35                  40                  45              


Arg Lys Gly His Lys Ile Tyr Glu Trp Glu Lys Ile Ile Gln Thr Val 
    50                  55                  60                  


Ser Pro Asn Thr Glu Val Glu Ile Ile Ile Glu Asn Val Asp Asn Ala 
65                  70                  75                  80  


Gln Asp Tyr Asp Val Phe Lys Glu Lys Phe His Lys Tyr Leu Lys Ile 
                85                  90                  95      


Ile Glu Asp Ser Tyr Glu Asp Cys Glu Ile Ile Leu Asn Val Thr Ser 
            100                 105                 110         


Gly Thr Pro Gln Met Glu Ser Thr Leu Cys Leu Glu Tyr Ile Val Tyr 
        115                 120                 125             


Pro Glu Asn Lys Lys Cys Val Gln Val Ser Thr Pro Thr Lys Asp Ser 
    130                 135                 140                 


Asn Ala Gly Ile Glu Tyr Ser Asn Pro Lys Asp Lys Val Glu Glu Phe 
145                 150                 155                 160 


Glu Ile Val Asn Glu Val Glu Lys Lys Ser Glu Lys Arg Cys Lys Glu 
                165                 170                 175     


Ile Asn Ile Leu 
            180 


<210>  5
<211>  173
<212>  PRT
<213>  Streptococcus thermophilus

<400>  5

Leu Lys Ile Leu Ile Ser Ala Val Gly Thr Thr Asp Pro Ile Ser Asn 
1               5                   10                  15      


Asn His Asp Ala Ala Leu Leu His Ile Ala Arg Asn Tyr Arg Pro Asp 
            20                  25                  30          


Lys Ile Val Leu Val Tyr Ser Gln Glu Met Met Val Lys Gln Asp Leu 
        35                  40                  45              


Ile Asn Lys Val Leu Leu Ser Ile Glu Gly Tyr Asn Pro Ile Ile Glu 
    50                  55                  60                  


Ile Asp Ser Thr Ile Leu Asn Asn Asp Glu Val Phe Leu Phe Asp Lys 
65                  70                  75                  80  


Met Tyr Glu Val Met Gly Gln Ile Val Gln Lys Tyr Thr Asn Asp Asp 
                85                  90                  95      


Asn Glu Ile Ile Leu Asn Leu Ser Ser Gly Thr Pro Gln Ile Ile Ser 
            100                 105                 110         


Ala Leu Phe Ala Leu Asn Arg Ile Asn Asp Tyr Asn Thr Gln Ala Ile 
        115                 120                 125             


Gln Val Ala Thr Pro Lys Asn Arg Ala Asn Arg Glu Tyr Thr Ala Leu 
    130                 135                 140                 


Thr Glu Ser Glu Ile Asp Ala Leu Ile Met Glu Asn Gln Asp Asn Arg 
145                 150                 155                 160 


Leu Asp Phe Val Asp Arg Ser Ile Lys Asp Lys Ser Glu 
                165                 170             


<210>  6
<211>  174
<212>  PRT
<213>  Streptococcus thermophilus

<400>  6

Met Arg Val Leu Ile Ser Ala Val Gly Asp Thr Asp Pro Phe Arg Asn 
1               5                   10                  15      


Phe His Asp Gly Ser Leu Ile His Ile Ala Arg Lys Tyr Arg Pro Glu 
            20                  25                  30          


Lys Val Ile Leu Ile Phe Ser Glu His Thr Ala Lys Lys Gln Gly Asn 
        35                  40                  45              


Ile Glu Lys Ala Leu Phe Ser Ile Ala Pro Asn Tyr Glu Pro Glu Leu 
    50                  55                  60                  


Ile Ile His Asp Pro Ile Ile Ser Asp Asn Glu Val His Ile Phe Asp 
65                  70                  75                  80  


Val Met Phe Gln Arg Phe Ser Asp Ile Leu Gln Glu Tyr Tyr Thr Lys 
                85                  90                  95      


Glu Asp Glu Phe Ile Leu Asn Leu Ser Ser Ala Thr Pro Gln Ile Lys 
            100                 105                 110         


Ser Ala Leu Phe Val Ile Asn Arg Leu Asn Gly Ile Asn Val Lys Ala 
        115                 120                 125             


Val Gln Val Ser Ser Pro Glu His Ala Ser Asn Glu Asn Ile Gly His 
    130                 135                 140                 


Asp Asn Asp Glu Asn Ile Asp Glu Leu Ile Glu Val Asn Lys Asp Asn 
145                 150                 155                 160 


Lys Val Asn Phe Ile Asp Arg Thr Ile Glu Asp Asn Ala Glu 
                165                 170                 


<210>  7
<211>  254
<212>  PRT
<213>  Streptococcus thermophilus

<400>  7

Thr Glu Gln Glu Thr Leu Thr Ile Leu Leu Asp Val Tyr Ala Tyr Tyr 
1               5                   10                  15      


Gln Ala Tyr Gln Ile Val Lys Ala Ser Gln Phe Phe Ser Asp Asp Ile 
            20                  25                  30          


Ile Phe Leu Leu Glu Leu Leu Lys Glu Arg Arg Glu Leu Asn Val Asp 
        35                  40                  45              


Phe Leu Phe Gln Asn Gln Val His Leu Gln Glu Leu Glu Leu Thr Tyr 
    50                  55                  60                  


His Ile Ser Leu Leu Asp Asn Ala Tyr Glu Glu Glu Leu Leu Ala Asn 
65                  70                  75                  80  


Tyr Ile Met Asp Leu Glu Ala Lys Leu Arg Asn Asp His Ile Ile Asp 
                85                  90                  95      


Phe Val Arg Ser Val Ser Pro Ile Leu Tyr Arg Leu Leu Met Arg Leu 
            100                 105                 110         


Met Gln Ser Gln Val Ala Asp Ile Asn Asp Tyr Ile Tyr Asp Ala Lys 
        115                 120                 125             


Asn Asp Gln Tyr Asp Thr Trp Lys Phe Asp Lys Met His Asp Ser Ala 
    130                 135                 140                 


Asn Pro Phe Val Gln Asn Phe Val Ala Lys Gly Arg Asp Ser Lys Ile 
145                 150                 155                 160 


Thr Ser Arg Ser Leu Ala Asp Phe Ile Gln Leu Thr Asp Leu Pro Gln 
                165                 170                 175     


Ala Ile Lys Asp Asn Ile Leu Leu Leu Arg Asp Phe Glu Lys Ser Val 
            180                 185                 190         


Arg Asn Pro Leu Ala His Leu Ile Lys Pro Phe Asp Glu Glu Glu Leu 
        195                 200                 205             


His Arg Thr Thr Gly Phe Ser Ser Gln Thr Phe Leu Glu Lys Ile Ile 
    210                 215                 220                 


Gln Leu Ala Val Phe Ser Gly Ile His Tyr Asp Asn Asp Lys Phe Tyr 
225                 230                 235                 240 


Phe Asp Lys Val Asn Glu Leu Ile Lys Arg Ile Tyr Gln Asn 
                245                 250                 


<210>  8
<211>  242
<212>  PRT
<213>  Streptococcus thermophilus

<400>  8

Ser Phe Arg Glu Ala Met Ile Arg Ser Gln Ile Leu Gly Leu Ile Asp 
1               5                   10                  15      


Asn Tyr Asp Tyr Glu Gly Ala Leu Asn Leu Val Ser Asn Gln Lys Ser 
            20                  25                  30          


Phe Arg Asn Gly Lys Leu Leu Arg Lys Lys Leu Leu Ser Leu Thr Lys 
        35                  40                  45              


Gln Ile Lys Thr His Glu Val Phe Pro Glu Ile Asn Glu Lys Tyr Arg 
    50                  55                  60                  


Asp Asp Ala Leu Lys Lys Ser Leu Phe His Tyr Leu Leu Leu Asn Met 
65                  70                  75                  80  


Arg Tyr Asn Arg Leu Asp Val Ala Glu Thr Leu Ile Arg Val Lys Ser 
                85                  90                  95      


Ile Ala Glu Phe Ile Leu Lys Thr Tyr Ile Glu Ile His Trp Pro Thr 
            100                 105                 110         


Leu Ile Ile Glu Lys Asp Gly Lys Pro Tyr Leu Asn Asp Glu Asp Asn 
        115                 120                 125             


Leu Ser Phe Val Tyr Lys Tyr Asn Leu Leu Leu Glu Lys Arg Lys Gln 
    130                 135                 140                 


Asn Phe Asp Val Ser Arg Ile Leu Gly Leu Pro Ala Phe Ile Asp Ile 
145                 150                 155                 160 


Leu Thr Ile Leu Glu Pro Asn Ser Gln Leu Leu Lys Glu Val Asn Ala 
                165                 170                 175     


Val Asn Asp Ile Asn Gly Leu Arg Asn Ser Ile Ala His Asn Leu Asp 
            180                 185                 190         


Thr Leu Asn Leu Asp Lys Asn Lys Asn Tyr Lys Lys Ile Met Leu Ser 
        195                 200                 205             


Val Glu Ala Ile Lys Asn Met Leu His Ile Ser Phe Pro Glu Ile Glu 
    210                 215                 220                 


Glu Glu Asp Tyr Asn Tyr Phe Glu Glu Lys Asn Lys Glu Phe Lys Glu 
225                 230                 235                 240 


Leu Leu 
        


<210>  9
<211>  255
<212>  PRT
<213>  Streptococcus thermophilus

<400>  9

Lys Phe Thr Gln Ala Leu Val Lys Arg His Leu Arg Ser Leu Ile Ala 
1               5                   10                  15      


Ser Phe Asp Tyr Gln Ala Ala Glu Ala Ile Ile Asn Arg Lys Glu Tyr 
            20                  25                  30          


Asn Lys Leu Leu Ser Lys Lys Lys Ile Ala Tyr Ile Arg Glu Lys Leu 
        35                  40                  45              


Tyr Asp Phe Ser Arg Val Phe Lys Asn Gln Ser Ile Leu Ser Asp Ile 
    50                  55                  60                  


Leu Ser Phe Pro Leu Asp Asp Ser Gln Lys Lys Ala Leu Asn Tyr Tyr 
65                  70                  75                  80  


Leu Met Ile Asp Val Leu Lys Glu Arg Glu His Ile Ala Asp Val Leu 
                85                  90                  95      


Ile Lys Ala Lys Ser Leu Ala Glu Phe Val Ile Glu Glu Thr Ile Lys 
            100                 105                 110         


Lys Asp His Glu Gly Leu Ile Val Phe Asp Gly Asn Leu Pro Lys Leu 
        115                 120                 125             


Asn Pro Ser Phe Pro Asp Cys Glu Ala Ile Leu Asp Asp Ile Asp Lys 
    130                 135                 140                 


Lys Met Lys Lys Ser Arg Gly Ile Glu Asp Thr Glu Glu Arg Ile Phe 
145                 150                 155                 160 


Ser Val Gln Ser Thr Leu Asn Leu Leu Ser Tyr Leu Asn Ile Leu Glu 
                165                 170                 175     


Phe Tyr Glu Tyr Asp Ser Gln Leu Gln Thr Ala Ile Asn Gly Ile Leu 
            180                 185                 190         


Ser Leu Asn Gly Glu Arg Asn Lys Val Ala His Gly Leu Ser Glu Ile 
        195                 200                 205             


Asp Thr Arg Leu Leu Ser Arg Lys Lys Leu Lys Gln Leu Ser Glu Asn 
    210                 215                 220                 


Leu Arg Leu Leu Leu Val Asp Cys Leu Gly Ile Asp Ser Ser Tyr Phe 
225                 230                 235                 240 


Asn Tyr Tyr Asp Lys Gln Asn Lys Glu Leu Ile Lys Met Leu Glu 
                245                 250                 255 


<210>  10
<211>  212
<212>  PRT
<213>  Streptococcus thermophilus

<400>  10

Lys Phe Ser Gln Ala Leu Leu Lys Lys Thr Ala Arg Asp Phe Ile Glu 
1               5                   10                  15      


Lys Phe Asp Tyr Lys Ala Ala Leu Asp Ile Leu Asp Gln Leu Ser Asp 
            20                  25                  30          


Phe Pro Asn Leu Lys Ser Val Arg Glu Glu Ile Arg Asp Val Val Asn 
        35                  40                  45              


Cys Leu Ser Lys Gln Asp Val Pro Lys Gly Leu Arg His Lys Lys Leu 
    50                  55                  60                  


Lys Glu Glu Glu Gln Lys Ile Leu Ser Ala Tyr Leu Thr Ile Glu Leu 
65                  70                  75                  80  


Gln Arg Glu Arg Gly Asn Val Ser Glu Ser Phe Ile Arg Ile Lys Asn 
                85                  90                  95      


Leu Thr Glu Phe Ile Leu Glu Asp Tyr Ile Glu Lys Arg Tyr Pro Gly 
            100                 105                 110         


Leu Ile Asp Glu Tyr Cys Glu Asp Ile Gln Lys Tyr Tyr Leu Ser Leu 
        115                 120                 125             


Phe Asp Tyr Ser Lys Leu Leu Lys Ala Thr Lys Glu Phe Lys Leu Lys 
    130                 135                 140                 


Arg Thr Ile Ala Pro Ile Ile Asp Met Asn Ser Ser Arg Asn Lys Val 
145                 150                 155                 160 


Ala His Ser Leu Ser Pro Leu Asp Ser Asp Ala Val Lys Gln Leu Gly 
                165                 170                 175     


Ile Ala Met Lys Thr Leu Lys Thr Leu Val Arg Glu Gln Tyr His Phe 
            180                 185                 190         


Ser Gln Ser Asp Phe Asn Phe Tyr His Asp Leu Asn Lys Ile Leu Leu 
        195                 200                 205             


Thr Lys Leu Asn 
    210         


<210>  11
<211>  68
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RNA NS

<400>  11
gggcggcaaa uugaggauuu cguaacuguu uaauucuguu cacuuauucc accaacaaaa       60

gguggcga                                                                68


<210>  12
<211>  78
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RNA NSc

<400>  12
gggaaacagc auagcaaguu aaaauaaggc uaguccguua ucaacuugaa aaaguggcac       60

cgagucggug cuuuuuuu                                                     78


<210>  13
<211>  80
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RNA NSd

<400>  13
ggguaaaucu ugcagaagcu acaaagauaa ggcuucaugc cgaaaucaac acccugucau       60

uuuauggcag gguguuuucg                                                   80


<210>  14
<211>  6
<212>  PRT
<213>  Streptococcus thermophilus


<220>
<221>  misc_feature
<222>  (2)..(5)
<223>  Xaa can be any naturally occurring amino acid

<400>  14

Arg Xaa Xaa Xaa Xaa His 
1               5       


<210>  15
<211>  52
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RNA NSe

<400>  15
ggguuuccca accauccagc cuaccggccg uccgaccugc cuucccuuuc cc               52


<210>  16
<211>  40
<212>  RNA
<213>  Streptococcus thermophilus

<400>  16
cuuauucacu ugucuuaauu ugucaaugcu uucaaaggca                             40


<210>  17
<211>  68
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RNA S3/2

<400>  17
gggaucccca aauauaaggu ggaauaagug aacagaauua aacaguuacg aaaaaaaaaa       60

aggguacc                                                                68


<210>  18
<211>  68
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RNA S3/3

<400>  18
gggaucccca aauauaaggu ggaauaagug aacagaauua aacaguuacg aaaguuuccg       60

uggguacc                                                                68


<210>  19
<211>  68
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RNA S3/7

<400>  19
gggaucccca aauauaaggu ggaauaagug aacagaauua aacaguuacc uaaaaaaaaa       60

aggguacc                                                                68


<210>  20
<211>  68
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RNA S3/15

<400>  20
gggaucccca aauauaaggu ggauaaagug aacagaauua aacaguuacg aaaaaaaaaa       60

aggguacc                                                                68


<210>  21
<211>  68
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RNA S3/9

<400>  21
gggaucccca aauauaaggu ggaauaagug aacacuauua aacaguuacg aaaaaaaaaa       60

aggguacc                                                                68


<210>  22
<211>  53
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RNA S3/10

<400>  22
gggaucccca aauauaaggu ggaauaagug aacagaauua aacaguuacg aaa              53


<210>  23
<211>  48
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RNA S3/14

<400>  23
ggaauaagug aacagaauua aacaguuacg aaaaaaaaaa aggguacc                    48


<210>  24
<211>  84
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  ssRNA NSa

<400>  24
ggguaccgag cucgaauuga aauucuaaac gcuaaagagg aagaggacau ggugaauucg       60

uaaucauggu cauagcuguu uccc                                              84


<210>  25
<211>  84
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  ssRNA NSb

<400>  25
gggaaacagc uaugaccaug auuacgaauu caccaugucc ucuuccucuu uagcguuuag       60

aauuucaauu cgagcucggu accc                                              84


<210>  26
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ssDNA S3/2

<400>  26
aaatataagg tggaataagt gaacagaatt aaacagttac gaaaaaaaaa aa               52


