                         SEQUENCE LISTING

<110>  AB Enzymes Oy
 
<120>  Mannanase variants, G

<130>  31603EP-1f_ALLMAN-G

<160>  26    

<170>  PatentIn version 3.5

<210>  1
<211>  1395
<212>  DNA
<213>  Bacillus hemicellulosilyticus

<400>  1
cagacccact cgggcttcta catcgagggc tcgacgctct acgacgctaa cggcgagcct       60

tttgtcatgc gcggcatcaa ccacggccac gcctggtaca agcacgactc caacgtcgct      120

atccctgcta tcgctaacca gggcgctaac accatccgca tcgtcctcag cgacggtggc      180

cagtgggcca aggacgacat caacacgctg aaccaggtcc tcgacctggc cgaggagcac      240

gagatgatcg ctgtcgtcga ggtccacgac gctaccggct ccaacagcat ggccgacctc      300

aaccgcgccg tcgactactg gatcgagatg aaggacgccc tgatcggcaa ggaagaccgc      360

gtcatcatca acatcgctaa cgagtggtac ggcgcttggg acggccaggg ctgggccaac      420

ggctacaagg aagtcatccc tcgcctgcgc aacgctggct tcacccacac cctcatggtc      480

gacgctgccg gctggggcca gtaccctcag agcatccacg actacggcca agaggtcttc      540

aacgccgacc ctctggccaa caccatgttc tccatccaca tgtacgagta cgctggcggc      600

aacgcctcca tggtccagag caacatcgac ggcgtcgtcg accagggcct cgctctggtc      660

atcggcgagt tcggccacat gcacacggac ggcgacgtcg acgaggctac catcctgagc      720

tactcgcagc agcgcggcgt cggctggctg gcctggtcgt ggaagggcaa cggcacccag      780

tgggagtacc tcgacctgag ctacgactgg cagggcacca acctcacgtc gtggggcaac      840

acgatcgtcc acggccctaa cggcctcctg gagacgtcca tcccttccag catctttcac      900

accgctccta acaacggcga ccctcctccc cacaacggca acgagacgat cctgtacgac      960

ttcgagcacg gcacgcaggg ctggtcgggc tcgtccctgc tgggcggccc ttggaccacc     1020

aacgagtggt cgaccaacgg caaccactcc ctcaaggccg acatcttcct gtccgccaac     1080

agcaagcacg agctcgccaa ggtcgagaac cgcaacctca gcggctactc gacgctgcag     1140

gctaccgtcc gccacgctca ctggggcaac gtcggcaacc tgacggctcg catgtacgtc     1200

aagacgggca gcaactactc gtggttcaac ggcgacccca tccctgtcaa ctcggctaac     1260

ggcaccaccg tcaccctccc tctgagctcg atccccaacc tcaacgacgt caaggagatc     1320

ggcgtcgagt tcatcggcgc tagcaacagc aacggccaga ccgccatcta cctggaccac     1380

gtcacgatcc agtaa                                                      1395


<210>  2
<211>  490
<212>  PRT
<213>  Bacillus hemicellulosilyticus

<400>  2

Met Arg Asn Phe Gly Lys Leu Ile Val Ser Ser Cys Leu Leu Phe Ser 
1               5                   10                  15      


Phe Phe Leu Phe Ala Ser Asp Gly His Ser Gln Thr His Ser Gly Phe 
            20                  25                  30          


Tyr Ile Glu Gly Ser Thr Leu Tyr Asp Ala Asn Gly Glu Pro Phe Val 
        35                  40                  45              


Met Arg Gly Ile Asn His Gly His Ala Trp Tyr Lys His Asp Ser Asn 
    50                  55                  60                  


Val Ala Ile Pro Ala Ile Ala Asn Gln Gly Ala Asn Thr Ile Arg Ile 
65                  70                  75                  80  


Val Leu Ser Asp Gly Gly Gln Trp Ala Lys Asp Asp Ile Asn Thr Leu 
                85                  90                  95      


Asn Gln Val Leu Asp Leu Ala Glu Glu His Glu Met Ile Ala Val Val 
            100                 105                 110         


Glu Val His Asp Ala Thr Gly Ser Asn Ser Met Ala Asp Leu Asn Arg 
        115                 120                 125             


Ala Val Asp Tyr Trp Ile Glu Met Lys Asp Ala Leu Ile Gly Lys Glu 
    130                 135                 140                 


Asp Arg Val Ile Ile Asn Ile Ala Asn Glu Trp Tyr Gly Ala Trp Asp 
145                 150                 155                 160 


Gly Gln Gly Trp Ala Asn Gly Tyr Lys Glu Val Ile Pro Arg Leu Arg 
                165                 170                 175     


Asn Ala Gly Phe Thr His Thr Leu Met Val Asp Ala Ala Gly Trp Gly 
            180                 185                 190         


Gln Tyr Pro Gln Ser Ile His Asp Tyr Gly Gln Glu Val Phe Asn Ala 
        195                 200                 205             


Asp Pro Leu Ala Asn Thr Met Phe Ser Ile His Met Tyr Glu Tyr Ala 
    210                 215                 220                 


Gly Gly Asn Ala Ser Met Val Gln Ser Asn Ile Asp Gly Val Val Asp 
225                 230                 235                 240 


Gln Gly Leu Ala Leu Val Ile Gly Glu Phe Gly His Met His Thr Asp 
                245                 250                 255     


Gly Asp Val Asp Glu Ala Thr Ile Leu Ser Tyr Ser Gln Gln Arg Gly 
            260                 265                 270         


Val Gly Trp Leu Ala Trp Ser Trp Lys Gly Asn Gly Thr Gln Trp Glu 
        275                 280                 285             


Tyr Leu Asp Leu Ser Tyr Asp Trp Gln Gly Thr Asn Leu Thr Ser Trp 
    290                 295                 300                 


Gly Asn Thr Ile Val His Gly Pro Asn Gly Leu Leu Glu Thr Ser Ile 
305                 310                 315                 320 


Pro Ser Ser Ile Phe His Thr Ala Pro Asn Asn Gly Asp Pro Pro Pro 
                325                 330                 335     


His Asn Gly Asn Glu Thr Ile Leu Tyr Asp Phe Glu His Gly Thr Gln 
            340                 345                 350         


Gly Trp Ser Gly Ser Ser Leu Leu Gly Gly Pro Trp Thr Thr Asn Glu 
        355                 360                 365             


Trp Ser Thr Asn Gly Asn His Ser Leu Lys Ala Asp Ile Phe Leu Ser 
    370                 375                 380                 


Ala Asn Ser Lys His Glu Leu Ala Lys Val Glu Asn Arg Asn Leu Ser 
385                 390                 395                 400 


Gly Tyr Ser Thr Leu Gln Ala Thr Val Arg His Ala His Trp Gly Asn 
                405                 410                 415     


Val Gly Asn Leu Thr Ala Arg Met Tyr Val Lys Thr Gly Ser Asn Tyr 
            420                 425                 430         


Ser Trp Phe Asn Gly Asp Pro Ile Pro Val Asn Ser Ala Asn Gly Thr 
        435                 440                 445             


Thr Val Thr Leu Pro Leu Ser Ser Ile Pro Asn Leu Asn Asp Val Lys 
    450                 455                 460                 


Glu Ile Gly Val Glu Phe Ile Gly Ala Ser Asn Ser Asn Gly Gln Thr 
465                 470                 475                 480 


Ala Ile Tyr Leu Asp His Val Thr Ile Gln 
                485                 490 


<210>  3
<211>  464
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant

<400>  3

Gln Thr His Ser Gly Phe Tyr Ile Glu Gly Ser Thr Leu Tyr Asp Ala 
1               5                   10                  15      


Asn Gly Glu Pro Phe Val Met Arg Gly Ile Asn His Gly His Ala Trp 
            20                  25                  30          


Tyr Lys His Asp Ser Asn Val Ala Ile Pro Ala Ile Ala Asn Gln Gly 
        35                  40                  45              


Ala Asn Thr Ile Arg Ile Val Leu Ser Asp Gly Gly Gln Trp Ala Lys 
    50                  55                  60                  


Asp Asp Ile Asn Thr Leu Asn Gln Val Leu Asp Leu Ala Glu Glu His 
65                  70                  75                  80  


Glu Met Ile Ala Val Val Glu Val His Asp Ala Thr Gly Ser Asn Ser 
                85                  90                  95      


Met Ala Asp Leu Asn Arg Ala Val Asp Tyr Trp Ile Glu Met Lys Asp 
            100                 105                 110         


Ala Leu Ile Gly Lys Glu Asp Arg Val Ile Ile Asn Ile Ala Asn Glu 
        115                 120                 125             


Trp Tyr Gly Ala Trp Asp Gly Gln Gly Trp Ala Asn Gly Tyr Lys Glu 
    130                 135                 140                 


Val Ile Pro Arg Leu Arg Asn Ala Gly Phe Thr His Thr Leu Met Val 
145                 150                 155                 160 


Asp Ala Ala Gly Trp Gly Gln Tyr Pro Gln Ser Ile His Asp Tyr Gly 
                165                 170                 175     


Gln Glu Val Phe Asn Ala Asp Pro Leu Ala Asn Thr Met Phe Ser Ile 
            180                 185                 190         


His Met Tyr Glu Tyr Ala Gly Gly Asn Ala Ser Met Val Gln Ser Asn 
        195                 200                 205             


Ile Asp Gly Val Val Asp Gln Gly Leu Ala Leu Val Ile Gly Glu Phe 
    210                 215                 220                 


Gly His Met His Thr Asp Gly Asp Val Asp Glu Ala Thr Ile Leu Ser 
225                 230                 235                 240 


Tyr Ser Gln Gln Arg Gly Val Gly Trp Leu Ala Trp Ser Trp Lys Gly 
                245                 250                 255     


Asn Gly Thr Gln Trp Glu Tyr Leu Asp Leu Ser Tyr Asp Trp Gln Gly 
            260                 265                 270         


Thr Asn Leu Thr Ser Trp Gly Asn Thr Ile Val His Gly Pro Asn Gly 
        275                 280                 285             


Leu Leu Glu Thr Ser Ile Pro Ser Ser Ile Phe His Thr Ala Pro Asn 
    290                 295                 300                 


Asn Gly Asp Pro Pro Pro His Asn Gly Asn Glu Thr Ile Leu Tyr Asp 
305                 310                 315                 320 


Phe Glu His Gly Thr Gln Gly Trp Ser Gly Ser Ser Leu Leu Gly Gly 
                325                 330                 335     


Pro Trp Thr Thr Asn Glu Trp Ser Thr Asn Gly Asn His Ser Leu Lys 
            340                 345                 350         


Ala Asp Ile Phe Leu Ser Ala Asn Ser Lys His Glu Leu Ala Lys Val 
        355                 360                 365             


Glu Asn Arg Asn Leu Ser Gly Tyr Ser Thr Leu Gln Ala Thr Val Arg 
    370                 375                 380                 


His Ala His Trp Gly Asn Val Gly Asn Leu Thr Ala Arg Met Tyr Val 
385                 390                 395                 400 


Lys Thr Gly Ser Asn Tyr Ser Trp Phe Asn Gly Asp Pro Ile Pro Val 
                405                 410                 415     


Asn Ser Ala Asn Gly Thr Thr Val Thr Leu Pro Leu Ser Ser Ile Pro 
            420                 425                 430         


Asn Leu Asn Asp Val Lys Glu Ile Gly Val Glu Phe Ile Gly Ala Ser 
        435                 440                 445             


Asn Ser Asn Gly Gln Thr Ala Ile Tyr Leu Asp His Val Thr Ile Gln 
    450                 455                 460                 


<210>  4
<211>  305
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant

<400>  4

Gln Thr His Ser Gly Phe Tyr Ile Glu Gly Ser Thr Leu Tyr Asp Ala 
1               5                   10                  15      


Asn Gly Glu Pro Phe Val Met Arg Gly Ile Asn His Gly His Ala Trp 
            20                  25                  30          


Tyr Lys His Asp Ser Asn Val Ala Ile Pro Ala Ile Ala Asn Gln Gly 
        35                  40                  45              


Ala Asn Thr Ile Arg Ile Val Leu Ser Asp Gly Gly Gln Trp Ala Lys 
    50                  55                  60                  


Asp Asp Ile Asn Thr Leu Asn Gln Val Leu Asp Leu Ala Glu Glu His 
65                  70                  75                  80  


Glu Met Ile Ala Val Val Glu Val His Asp Ala Thr Gly Ser Asn Ser 
                85                  90                  95      


Met Ala Asp Leu Asn Arg Ala Val Asp Tyr Trp Ile Glu Met Lys Asp 
            100                 105                 110         


Ala Leu Ile Gly Lys Glu Asp Arg Val Ile Ile Asn Ile Ala Asn Glu 
        115                 120                 125             


Trp Tyr Gly Ala Trp Asp Gly Gln Gly Trp Ala Asn Gly Tyr Lys Glu 
    130                 135                 140                 


Val Ile Pro Arg Leu Arg Asn Ala Gly Phe Thr His Thr Leu Met Val 
145                 150                 155                 160 


Asp Ala Ala Gly Trp Gly Gln Tyr Pro Gln Ser Ile His Asp Tyr Gly 
                165                 170                 175     


Gln Glu Val Phe Asn Ala Asp Pro Leu Ala Asn Thr Met Phe Ser Ile 
            180                 185                 190         


His Met Tyr Glu Tyr Ala Gly Gly Asn Ala Ser Met Val Gln Ser Asn 
        195                 200                 205             


Ile Asp Gly Val Val Asp Gln Gly Leu Ala Leu Val Ile Gly Glu Phe 
    210                 215                 220                 


Gly His Met His Thr Asp Gly Asp Val Asp Glu Ala Thr Ile Leu Ser 
225                 230                 235                 240 


Tyr Ser Gln Gln Arg Gly Val Gly Trp Leu Ala Trp Ser Trp Lys Gly 
                245                 250                 255     


Asn Gly Thr Gln Trp Glu Tyr Leu Asp Leu Ser Tyr Asp Trp Gln Gly 
            260                 265                 270         


Thr Asn Leu Thr Ser Trp Gly Asn Thr Ile Val His Gly Pro Asn Gly 
        275                 280                 285             


Leu Leu Glu Thr Ser Ile Pro Ser Ser Ile Phe His Thr Ala Pro Asn 
    290                 295                 300                 


Asn 
305 


<210>  5
<211>  1395
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  variant

<400>  5
cagacccact ccggcttcta catcgagggc agcacgctct acgacgctaa cggcgagcct       60

tttgtcatgc gcggcatcaa ccacggccac gcctggtaca agcacgactc caacgtcgcc      120

atccctgcta tcgccaacca gggcgctaac accatccgca tcgtcctcag cgacggtggc      180

cagtgggcca aggacgacat caacacgctg aaccaggtcc tcgacctggc cgaggagcac      240

gagatgatcg ctgtcgtcga ggtccacgac gctaccggca gcaactcgat cgccgacctc      300

aaccgcgccg tcgactactg gatcgagatg aaggacgccc tgatcggcaa ggaagaccgc      360

gtcatcatca acatcgccaa cgagtggtac ggcgcttggg acggccaggg ctgggccaac      420

ggctacaagg aagtcatccc ccgcctgcgc aacgctggct tcacccacac cctcatggtc      480

gacgctgctg gctggggcca gtacccccag agcatccacg actacggcca agaggtcttc      540

aacgccgacc ctctggccaa caccatgttc agcatccaca tgtacgagta cgctggcggc      600

aacgctgcta tggtccagtc gaacatcgac ggcgtcgtcg accagggcct cgctctggtc      660

atcggcgagt tcggccacat gcacacggac ggcgacgtcg acgaggctac catcctctcg      720

tactcgcagc agcgccaggt cggctggctc gcttggagct ggaagggcaa cggcgctcag      780

tgggagtacc tcgacctgtc gtacgactgg cagggcacca acctcacgtc ctggggcaac      840

accatcgtcc acggccctaa cggcctcctg gagacgtcga tccctagctc gatctttcac      900

accgctccta acaacggcga ccctcctccc cacaacggca acgagacgat cctgtacgac      960

ttcgagcacg gcacgcaggg ctggtcgggc tccagcctgc tgggcggccc ttggaccacc     1020

aacgagtgga gcacgaacgg caaccactcg ctcaaggccg acatcttcct gagcgccaac     1080

tcgaagcacg agctcgccaa ggtcgagaac cgcaacctct cgggctactc gacgctgcag     1140

gctaccgtcc gccacgctca ctggggcaac gtcggcaacc tgacggctcg catgtacgtc     1200

aagacgggct cgaactactc ctggttcaac ggcgacccca tccctgtcaa ctcggctaac     1260

ggcaccaccg tcaccctccc tctgagctcc atccccaacc tcaacgacgt caaggagatc     1320

ggcgtcgagt tcatcggcgc tagcaactcg aacggccaga ccgccatcta cctggaccac     1380

gtcacgatcc agtag                                                      1395


<210>  6
<211>  464
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant

<400>  6

Gln Thr His Ser Gly Phe Tyr Ile Glu Gly Ser Thr Leu Tyr Asp Ala 
1               5                   10                  15      


Asn Gly Glu Pro Phe Val Met Arg Gly Ile Asn His Gly His Ala Trp 
            20                  25                  30          


Tyr Lys His Asp Ser Asn Val Ala Ile Pro Ala Ile Ala Asn Gln Gly 
        35                  40                  45              


Ala Asn Thr Ile Arg Ile Val Leu Ser Asp Gly Gly Gln Trp Ala Lys 
    50                  55                  60                  


Asp Asp Ile Asn Thr Leu Asn Gln Val Leu Asp Leu Ala Glu Glu His 
65                  70                  75                  80  


Glu Met Ile Ala Val Val Glu Val His Asp Ala Thr Gly Ser Asn Ser 
                85                  90                  95      


Ile Ala Asp Leu Asn Arg Ala Val Asp Tyr Trp Ile Glu Met Lys Asp 
            100                 105                 110         


Ala Leu Ile Gly Lys Glu Asp Arg Val Ile Ile Asn Ile Ala Asn Glu 
        115                 120                 125             


Trp Tyr Gly Ala Trp Asp Gly Gln Gly Trp Ala Asn Gly Tyr Lys Glu 
    130                 135                 140                 


Val Ile Pro Arg Leu Arg Asn Ala Gly Phe Thr His Thr Leu Met Val 
145                 150                 155                 160 


Asp Ala Ala Gly Trp Gly Gln Tyr Pro Gln Ser Ile His Asp Tyr Gly 
                165                 170                 175     


Gln Glu Val Phe Asn Ala Asp Pro Leu Ala Asn Thr Met Phe Ser Ile 
            180                 185                 190         


His Met Tyr Glu Tyr Ala Gly Gly Asn Ala Ala Met Val Gln Ser Asn 
        195                 200                 205             


Ile Asp Gly Val Val Asp Gln Gly Leu Ala Leu Val Ile Gly Glu Phe 
    210                 215                 220                 


Gly His Met His Thr Asp Gly Asp Val Asp Glu Ala Thr Ile Leu Ser 
225                 230                 235                 240 


Tyr Ser Gln Gln Arg Gln Val Gly Trp Leu Ala Trp Ser Trp Lys Gly 
                245                 250                 255     


Asn Gly Ala Gln Trp Glu Tyr Leu Asp Leu Ser Tyr Asp Trp Gln Gly 
            260                 265                 270         


Thr Asn Leu Thr Ser Trp Gly Asn Thr Ile Val His Gly Pro Asn Gly 
        275                 280                 285             


Leu Leu Glu Thr Ser Ile Pro Ser Ser Ile Phe His Thr Ala Pro Asn 
    290                 295                 300                 


Asn Gly Asp Pro Pro Pro His Asn Gly Asn Glu Thr Ile Leu Tyr Asp 
305                 310                 315                 320 


Phe Glu His Gly Thr Gln Gly Trp Ser Gly Ser Ser Leu Leu Gly Gly 
                325                 330                 335     


Pro Trp Thr Thr Asn Glu Trp Ser Thr Asn Gly Asn His Ser Leu Lys 
            340                 345                 350         


Ala Asp Ile Phe Leu Ser Ala Asn Ser Lys His Glu Leu Ala Lys Val 
        355                 360                 365             


Glu Asn Arg Asn Leu Ser Gly Tyr Ser Thr Leu Gln Ala Thr Val Arg 
    370                 375                 380                 


His Ala His Trp Gly Asn Val Gly Asn Leu Thr Ala Arg Met Tyr Val 
385                 390                 395                 400 


Lys Thr Gly Ser Asn Tyr Ser Trp Phe Asn Gly Asp Pro Ile Pro Val 
                405                 410                 415     


Asn Ser Ala Asn Gly Thr Thr Val Thr Leu Pro Leu Ser Ser Ile Pro 
            420                 425                 430         


Asn Leu Asn Asp Val Lys Glu Ile Gly Val Glu Phe Ile Gly Ala Ser 
        435                 440                 445             


Asn Ser Asn Gly Gln Thr Ala Ile Tyr Leu Asp His Val Thr Ile Gln 
    450                 455                 460                 


<210>  7
<211>  1395
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  variant

<400>  7
cagacccact ccggcttcta catcgagggc agcacgctct acgacgctaa cggcgagcct       60

tttgtcatgc gcggcatcaa ccacggccac gcctggtaca agcacgactc caacgtcgcc      120

atccctgcta tcgccaacca gggcgctaac accatccgca tcgtcctcag cgacggtggc      180

cagtgggcca aggacgacat caacacgctg aaccaggtcc tcgacctggc cgaggagcac      240

gagatgatcg ctgtcgtcga ggtccacgac gctaccggca gcaactcgat ggccgacctc      300

aaccgcgccg tcgactactg gatcgagatg aaggacgccc tgatcggcaa ggaagaccgc      360

gtcatcatca acatcgccaa cgagtggtac ggcagctggg acggccaggg ctgggccaac      420

ggctacaagg aagtcatccc ccgcctgcgc aacgctggct tcacccacac cctcatggtc      480

gacgctgctg gctggggcca gtacccccag tcgatccacg actacggcca agaggtcttc      540

aacgccgacc ctctggccaa caccatgttc agcatccaca tgtacgagta cgctggcggc      600

aacgctgcta tggtccagtc gaacatcgac ggcgtcgtcg accagggcct cgctctggtc      660

atcggcgagt tcggccacat gcacacggac ggcgacgtcg acgaggctac catcctgtcc      720

tactcgcagc agcgcggcgt cggctggctc gcttggtcgt ggaagggcaa cggcgctcag      780

tgggagtacc tcgacctgtc gtacgactgg cagggcacca acctcacctc gtggggcaac      840

cgcatcgtcc acggccctaa cggcctcctg gagacgtcga tccctagctc gatctttcac      900

accgctccta acaacggcga ccctcctccc cacaacggca acgagacgat cctgtacgac      960

ttcgagcacg gcacgcaggg ctggtcgggc tccagcctgc tgggcggccc ttggaccacc     1020

aacgagtgga gcaccaacgg caaccactcg ctcaaggccg acatcttcct gagcgccaac     1080

tcgaagcacg agctcgccaa ggtcgagaac cgcaacctct cgggctactc gacgctgcag     1140

gctaccgtcc gccacgctca ctggggcaac gtcggcaacc tgacggctcg catgtacgtc     1200

aagacgggct cgaactactc ctggttcaac ggcgacccca tccctgtcaa ctcggctaac     1260

ggcaccaccg tcaccctccc tctgagctcc atccccaacc tcaacgacgt caaggagatc     1320

ggcgtcgagt tcatcggcgc tagcaactcg aacggccaga ccgccatcta cctggaccac     1380

gtcacgatcc agtag                                                      1395


<210>  8
<211>  464
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant

<400>  8

Gln Thr His Ser Gly Phe Tyr Ile Glu Gly Ser Thr Leu Tyr Asp Ala 
1               5                   10                  15      


Asn Gly Glu Pro Phe Val Met Arg Gly Ile Asn His Gly His Ala Trp 
            20                  25                  30          


Tyr Lys His Asp Ser Asn Val Ala Ile Pro Ala Ile Ala Asn Gln Gly 
        35                  40                  45              


Ala Asn Thr Ile Arg Ile Val Leu Ser Asp Gly Gly Gln Trp Ala Lys 
    50                  55                  60                  


Asp Asp Ile Asn Thr Leu Asn Gln Val Leu Asp Leu Ala Glu Glu His 
65                  70                  75                  80  


Glu Met Ile Ala Val Val Glu Val His Asp Ala Thr Gly Ser Asn Ser 
                85                  90                  95      


Met Ala Asp Leu Asn Arg Ala Val Asp Tyr Trp Ile Glu Met Lys Asp 
            100                 105                 110         


Ala Leu Ile Gly Lys Glu Asp Arg Val Ile Ile Asn Ile Ala Asn Glu 
        115                 120                 125             


Trp Tyr Gly Ser Trp Asp Gly Gln Gly Trp Ala Asn Gly Tyr Lys Glu 
    130                 135                 140                 


Val Ile Pro Arg Leu Arg Asn Ala Gly Phe Thr His Thr Leu Met Val 
145                 150                 155                 160 


Asp Ala Ala Gly Trp Gly Gln Tyr Pro Gln Ser Ile His Asp Tyr Gly 
                165                 170                 175     


Gln Glu Val Phe Asn Ala Asp Pro Leu Ala Asn Thr Met Phe Ser Ile 
            180                 185                 190         


His Met Tyr Glu Tyr Ala Gly Gly Asn Ala Ala Met Val Gln Ser Asn 
        195                 200                 205             


Ile Asp Gly Val Val Asp Gln Gly Leu Ala Leu Val Ile Gly Glu Phe 
    210                 215                 220                 


Gly His Met His Thr Asp Gly Asp Val Asp Glu Ala Thr Ile Leu Ser 
225                 230                 235                 240 


Tyr Ser Gln Gln Arg Gly Val Gly Trp Leu Ala Trp Ser Trp Lys Gly 
                245                 250                 255     


Asn Gly Ala Gln Trp Glu Tyr Leu Asp Leu Ser Tyr Asp Trp Gln Gly 
            260                 265                 270         


Thr Asn Leu Thr Ser Trp Gly Asn Arg Ile Val His Gly Pro Asn Gly 
        275                 280                 285             


Leu Leu Glu Thr Ser Ile Pro Ser Ser Ile Phe His Thr Ala Pro Asn 
    290                 295                 300                 


Asn Gly Asp Pro Pro Pro His Asn Gly Asn Glu Thr Ile Leu Tyr Asp 
305                 310                 315                 320 


Phe Glu His Gly Thr Gln Gly Trp Ser Gly Ser Ser Leu Leu Gly Gly 
                325                 330                 335     


Pro Trp Thr Thr Asn Glu Trp Ser Thr Asn Gly Asn His Ser Leu Lys 
            340                 345                 350         


Ala Asp Ile Phe Leu Ser Ala Asn Ser Lys His Glu Leu Ala Lys Val 
        355                 360                 365             


Glu Asn Arg Asn Leu Ser Gly Tyr Ser Thr Leu Gln Ala Thr Val Arg 
    370                 375                 380                 


His Ala His Trp Gly Asn Val Gly Asn Leu Thr Ala Arg Met Tyr Val 
385                 390                 395                 400 


Lys Thr Gly Ser Asn Tyr Ser Trp Phe Asn Gly Asp Pro Ile Pro Val 
                405                 410                 415     


Asn Ser Ala Asn Gly Thr Thr Val Thr Leu Pro Leu Ser Ser Ile Pro 
            420                 425                 430         


Asn Leu Asn Asp Val Lys Glu Ile Gly Val Glu Phe Ile Gly Ala Ser 
        435                 440                 445             


Asn Ser Asn Gly Gln Thr Ala Ile Tyr Leu Asp His Val Thr Ile Gln 
    450                 455                 460                 


<210>  9
<211>  1395
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  variant

<400>  9
cagacccact ccggcttcta catcgagggc agcacgctct acgacgctaa cggcgagcct       60

tttgtcatgc gcggcatcaa ccacggccac gcctggtaca agcacgactc caacgtcgcc      120

atccctgcta tcgccaacca gggcgctaac accatccgca tcgtcctcag cgacggtggc      180

cagtgggcca aggacgacat caacacgctg aaccaggtcc tcgacctggc cgaggagcac      240

gagatgatcg ctgtcgtcga ggtccacgac gctaccggca gcaactcgat ggccgacctc      300

aaccgcgccg tcgactactg gatcgagatg aaggacgccc tgatcggcaa ggaagaccgc      360

gtcatcatca acatcgccaa cgagtggtac ggcgcttggg acggccaggg ctgggccaac      420

ggctacaagg aagtcatccc ccgcctgcgc aacgctggct tcacccacac cctcatggtc      480

gacgctgctg gctggggcca gtacccccag agcatccacg actacggcca agaggtcttc      540

aacgccgacc ctctcgccaa caccatgttc agcatccaca tgtacgagta cgctggcggc      600

aacgctgcta tggtccagtc gaacatcgac ggcgtcgtcg accagggcct cgctctggtc      660

atcggcgagt tcggccacat gcacacggac ggcgacgtcg acgaggctac catcctgtcc      720

tactcgcagc agcgcggcgt cggctggctc gcttggagct ggaagggcaa cggcgctcag      780

tgggagtacc tcgacctgtc gtacgactgg cagggcacca acctcacgtc ctggggcaac      840

accatcgtcc acggccctaa cggcctgaag gagacgtcga tccctagctc gatctttcac      900

accgctccta acaacggcga ccctcctccc cacaacggca acgagacgat cctgtacgac      960

ttcgagcacg gcacgcaggg ctggtcgggc tccagcctgc tgggcggccc ttggaccacc     1020

aacgagtgga gcacgaacgg caaccactcg ctcaaggccg acatcttcct gagcgccaac     1080

tcgaagcacg agctcgccaa ggtcgagaac cgcaacctct cgggctactc gacgctgcag     1140

gctaccgtcc gccacgctca ctggggcaac gtcggcaacc tgacggctcg catgtacgtc     1200

aagacgggct cgaactactc ctggttcaac ggcgacccca tccctgtcaa ctcggctaac     1260

ggcaccaccg tcaccctccc tctgagctcc atccccaacc tcaacgacgt caaggagatc     1320

ggcgtcgagt tcatcggcgc tagcaactcg aacggccaga ccgccatcta cctggaccac     1380

gtcacgatcc agtag                                                      1395


<210>  10
<211>  464
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant

<400>  10

Gln Thr His Ser Gly Phe Tyr Ile Glu Gly Ser Thr Leu Tyr Asp Ala 
1               5                   10                  15      


Asn Gly Glu Pro Phe Val Met Arg Gly Ile Asn His Gly His Ala Trp 
            20                  25                  30          


Tyr Lys His Asp Ser Asn Val Ala Ile Pro Ala Ile Ala Asn Gln Gly 
        35                  40                  45              


Ala Asn Thr Ile Arg Ile Val Leu Ser Asp Gly Gly Gln Trp Ala Lys 
    50                  55                  60                  


Asp Asp Ile Asn Thr Leu Asn Gln Val Leu Asp Leu Ala Glu Glu His 
65                  70                  75                  80  


Glu Met Ile Ala Val Val Glu Val His Asp Ala Thr Gly Ser Asn Ser 
                85                  90                  95      


Met Ala Asp Leu Asn Arg Ala Val Asp Tyr Trp Ile Glu Met Lys Asp 
            100                 105                 110         


Ala Leu Ile Gly Lys Glu Asp Arg Val Ile Ile Asn Ile Ala Asn Glu 
        115                 120                 125             


Trp Tyr Gly Ala Trp Asp Gly Gln Gly Trp Ala Asn Gly Tyr Lys Glu 
    130                 135                 140                 


Val Ile Pro Arg Leu Arg Asn Ala Gly Phe Thr His Thr Leu Met Val 
145                 150                 155                 160 


Asp Ala Ala Gly Trp Gly Gln Tyr Pro Gln Ser Ile His Asp Tyr Gly 
                165                 170                 175     


Gln Glu Val Phe Asn Ala Asp Pro Leu Ala Asn Thr Met Phe Ser Ile 
            180                 185                 190         


His Met Tyr Glu Tyr Ala Gly Gly Asn Ala Ala Met Val Gln Ser Asn 
        195                 200                 205             


Ile Asp Gly Val Val Asp Gln Gly Leu Ala Leu Val Ile Gly Glu Phe 
    210                 215                 220                 


Gly His Met His Thr Asp Gly Asp Val Asp Glu Ala Thr Ile Leu Ser 
225                 230                 235                 240 


Tyr Ser Gln Gln Arg Gly Val Gly Trp Leu Ala Trp Ser Trp Lys Gly 
                245                 250                 255     


Asn Gly Ala Gln Trp Glu Tyr Leu Asp Leu Ser Tyr Asp Trp Gln Gly 
            260                 265                 270         


Thr Asn Leu Thr Ser Trp Gly Asn Thr Ile Val His Gly Pro Asn Gly 
        275                 280                 285             


Leu Lys Glu Thr Ser Ile Pro Ser Ser Ile Phe His Thr Ala Pro Asn 
    290                 295                 300                 


Asn Gly Asp Pro Pro Pro His Asn Gly Asn Glu Thr Ile Leu Tyr Asp 
305                 310                 315                 320 


Phe Glu His Gly Thr Gln Gly Trp Ser Gly Ser Ser Leu Leu Gly Gly 
                325                 330                 335     


Pro Trp Thr Thr Asn Glu Trp Ser Thr Asn Gly Asn His Ser Leu Lys 
            340                 345                 350         


Ala Asp Ile Phe Leu Ser Ala Asn Ser Lys His Glu Leu Ala Lys Val 
        355                 360                 365             


Glu Asn Arg Asn Leu Ser Gly Tyr Ser Thr Leu Gln Ala Thr Val Arg 
    370                 375                 380                 


His Ala His Trp Gly Asn Val Gly Asn Leu Thr Ala Arg Met Tyr Val 
385                 390                 395                 400 


Lys Thr Gly Ser Asn Tyr Ser Trp Phe Asn Gly Asp Pro Ile Pro Val 
                405                 410                 415     


Asn Ser Ala Asn Gly Thr Thr Val Thr Leu Pro Leu Ser Ser Ile Pro 
            420                 425                 430         


Asn Leu Asn Asp Val Lys Glu Ile Gly Val Glu Phe Ile Gly Ala Ser 
        435                 440                 445             


Asn Ser Asn Gly Gln Thr Ala Ile Tyr Leu Asp His Val Thr Ile Gln 
    450                 455                 460                 


<210>  11
<211>  1395
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  variant

<400>  11
cagacccact ccggcttcta catcgagggc agcacgctct acgacgctaa cggcgagcct       60

tttgtcatgc gcggcatcaa ccacggccac gcctggtaca agcacgactc caacgtcgcc      120

atccctgcta tcgccaacca gggcgctaac accatccgca tcgtcctcag cgacggtggc      180

cagtgggcca aggacgacat caacacgctg aaccaggtcc tcgacctggc cgaggagcac      240

gagatgatcg ctgtcgtcga ggtccacgac gctaccggca gcaactcgat cgccgacctc      300

aaccgcgccg tcgactactg gatcgagatg aaggacgccc tgatcggcaa ggaagaccgc      360

gtcatcatca acatcgccaa cgagtggtac ggctcttggg acggccaggg ctgggccaac      420

ggctacaagg aagtcatccc ccgcctgcgc aacgctggct tcacccacac cctcatggtc      480

gacgctgctg gctggggcca gtacccccag agcatccacg actacggcca agaggtcttc      540

aacgccgacc ctctggccaa caccatgttc agcatccaca tgtacgagta cgctggcggc      600

aacgctgcta tggtccagtc gaacatcgac ggcgtcgtcg accagggcct cgctctggtc      660

atcggcgagt tcggccacat gcacacggac ggcgacgtcg acgaggctac catcctctcg      720

tactcgcagc agcgccaggt cggctggctc gcttggagct ggaagggcaa cggcgctcag      780

tgggagtacc tcgacctgtc gtacgactgg cagggcacca acctcacgtc ctggggcaac      840

agaatcgtcc acggccctaa cggcctcctg gagacgtcga tccctagctc gatctttcac      900

accgctccta acaacggcga ccctcctccc cacaacggca acgagacgat cctgtacgac      960

ttcgagcacg gcacgcaggg ctggtcgggc tccagcctgc tgggcggccc ttggaccacc     1020

aacgagtgga gcacgaacgg caaccactcg ctcaaggccg acatcttcct gagcgccaac     1080

tcgaagcacg agctcgccaa ggtcgagaac cgcaacctct cgggctactc gacgctgcag     1140

gctaccgtcc gccacgctca ctggggcaac gtcggcaacc tgacggctcg catgtacgtc     1200

aagacgggct cgaactactc ctggttcaac ggcgacccca tccctgtcaa ctcggctaac     1260

ggcaccaccg tcaccctccc tctgagctcc atccccaacc tcaacgacgt caaggagatc     1320

ggcgtcgagt tcatcggcgc tagcaactcg aacggccaga ccgccatcta cctggaccac     1380

gtcacgatcc agtag                                                      1395


<210>  12
<211>  464
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant

<400>  12

Gln Thr His Ser Gly Phe Tyr Ile Glu Gly Ser Thr Leu Tyr Asp Ala 
1               5                   10                  15      


Asn Gly Glu Pro Phe Val Met Arg Gly Ile Asn His Gly His Ala Trp 
            20                  25                  30          


Tyr Lys His Asp Ser Asn Val Ala Ile Pro Ala Ile Ala Asn Gln Gly 
        35                  40                  45              


Ala Asn Thr Ile Arg Ile Val Leu Ser Asp Gly Gly Gln Trp Ala Lys 
    50                  55                  60                  


Asp Asp Ile Asn Thr Leu Asn Gln Val Leu Asp Leu Ala Glu Glu His 
65                  70                  75                  80  


Glu Met Ile Ala Val Val Glu Val His Asp Ala Thr Gly Ser Asn Ser 
                85                  90                  95      


Ile Ala Asp Leu Asn Arg Ala Val Asp Tyr Trp Ile Glu Met Lys Asp 
            100                 105                 110         


Ala Leu Ile Gly Lys Glu Asp Arg Val Ile Ile Asn Ile Ala Asn Glu 
        115                 120                 125             


Trp Tyr Gly Ser Trp Asp Gly Gln Gly Trp Ala Asn Gly Tyr Lys Glu 
    130                 135                 140                 


Val Ile Pro Arg Leu Arg Asn Ala Gly Phe Thr His Thr Leu Met Val 
145                 150                 155                 160 


Asp Ala Ala Gly Trp Gly Gln Tyr Pro Gln Ser Ile His Asp Tyr Gly 
                165                 170                 175     


Gln Glu Val Phe Asn Ala Asp Pro Leu Ala Asn Thr Met Phe Ser Ile 
            180                 185                 190         


His Met Tyr Glu Tyr Ala Gly Gly Asn Ala Ala Met Val Gln Ser Asn 
        195                 200                 205             


Ile Asp Gly Val Val Asp Gln Gly Leu Ala Leu Val Ile Gly Glu Phe 
    210                 215                 220                 


Gly His Met His Thr Asp Gly Asp Val Asp Glu Ala Thr Ile Leu Ser 
225                 230                 235                 240 


Tyr Ser Gln Gln Arg Gln Val Gly Trp Leu Ala Trp Ser Trp Lys Gly 
                245                 250                 255     


Asn Gly Ala Gln Trp Glu Tyr Leu Asp Leu Ser Tyr Asp Trp Gln Gly 
            260                 265                 270         


Thr Asn Leu Thr Ser Trp Gly Asn Arg Ile Val His Gly Pro Asn Gly 
        275                 280                 285             


Leu Leu Glu Thr Ser Ile Pro Ser Ser Ile Phe His Thr Ala Pro Asn 
    290                 295                 300                 


Asn Gly Asp Pro Pro Pro His Asn Gly Asn Glu Thr Ile Leu Tyr Asp 
305                 310                 315                 320 


Phe Glu His Gly Thr Gln Gly Trp Ser Gly Ser Ser Leu Leu Gly Gly 
                325                 330                 335     


Pro Trp Thr Thr Asn Glu Trp Ser Thr Asn Gly Asn His Ser Leu Lys 
            340                 345                 350         


Ala Asp Ile Phe Leu Ser Ala Asn Ser Lys His Glu Leu Ala Lys Val 
        355                 360                 365             


Glu Asn Arg Asn Leu Ser Gly Tyr Ser Thr Leu Gln Ala Thr Val Arg 
    370                 375                 380                 


His Ala His Trp Gly Asn Val Gly Asn Leu Thr Ala Arg Met Tyr Val 
385                 390                 395                 400 


Lys Thr Gly Ser Asn Tyr Ser Trp Phe Asn Gly Asp Pro Ile Pro Val 
                405                 410                 415     


Asn Ser Ala Asn Gly Thr Thr Val Thr Leu Pro Leu Ser Ser Ile Pro 
            420                 425                 430         


Asn Leu Asn Asp Val Lys Glu Ile Gly Val Glu Phe Ile Gly Ala Ser 
        435                 440                 445             


Asn Ser Asn Gly Gln Thr Ala Ile Tyr Leu Asp His Val Thr Ile Gln 
    450                 455                 460                 


<210>  13
<211>  1395
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  variant

<400>  13
cagacccact ccggcttcta catcgagggc agcacgctct acgacgctaa cggcgagcct       60

tttgtcatgc gcggcatcaa ccacggccac gcctggtaca agcacgactc caacgtcgcc      120

atccctgcta tcgccaacca gggcgctaac accatccgca tcgtcctcag cgacggtggc      180

cagtgggcca aggacgacat caacacgctg aaccaggtcc tcgacctggc cgaggagcac      240

gagatgatcg ctgtcgtcga ggtccacgac gctaccggca gcaactcgat cgccgacctc      300

aaccgcgccg tcgactactg gatcgagatg aaggacgccc tgatcggcaa ggaagaccgc      360

gtcatcatca acatcgccaa cgagtggtac ggcgcttggg acggccaggg ctgggccaac      420

ggctacaagg aagtcatccc ccgcctgcgc aacgctggct tcacccacac cctcatggtc      480

gacgctgctg gctggggcca gtacccccag agcatccacg actacggcca agaggtcttc      540

aacgccgacc ctctggccaa caccatgttc agcatccaca tgtacgagta cgctggcggc      600

aacgctgcta tggtccagtc gaacatcgac ggcgtcgtcg accagggcct cgctctggtc      660

atcggcgagt tcggccacat gcacacggac ggcgacgtcg acgaggctac catcctctcg      720

tactcgcagc agcgccaggt cggctggctc gcttggagct ggaagggcaa cggcgctcag      780

tgggagtacc tcgacctgtc gtacgactgg cagggcacca acctcacgtc ctggggcaac      840

accatcgtcc acggccctaa cggcctcaaa gagacgtcga tccctagctc gatctttcac      900

accgctccta acaacggcga ccctcctccc cacaacggca acgagacgat cctgtacgac      960

ttcgagcacg gcacgcaggg ctggtcgggc tccagcctgc tgggcggccc ttggaccacc     1020

aacgagtgga gcacgaacgg caaccactcg ctcaaggccg acatcttcct gagcgccaac     1080

tcgaagcacg agctcgccaa ggtcgagaac cgcaacctct cgggctactc gacgctgcag     1140

gctaccgtcc gccacgctca ctggggcaac gtcggcaacc tgacggctcg catgtacgtc     1200

aagacgggct cgaactactc ctggttcaac ggcgacccca tccctgtcaa ctcggctaac     1260

ggcaccaccg tcaccctccc tctgagctcc atccccaacc tcaacgacgt caaggagatc     1320

ggcgtcgagt tcatcggcgc tagcaactcg aacggccaga ccgccatcta cctggaccac     1380

gtcacgatcc agtag                                                      1395


<210>  14
<211>  464
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant

<400>  14

Gln Thr His Ser Gly Phe Tyr Ile Glu Gly Ser Thr Leu Tyr Asp Ala 
1               5                   10                  15      


Asn Gly Glu Pro Phe Val Met Arg Gly Ile Asn His Gly His Ala Trp 
            20                  25                  30          


Tyr Lys His Asp Ser Asn Val Ala Ile Pro Ala Ile Ala Asn Gln Gly 
        35                  40                  45              


Ala Asn Thr Ile Arg Ile Val Leu Ser Asp Gly Gly Gln Trp Ala Lys 
    50                  55                  60                  


Asp Asp Ile Asn Thr Leu Asn Gln Val Leu Asp Leu Ala Glu Glu His 
65                  70                  75                  80  


Glu Met Ile Ala Val Val Glu Val His Asp Ala Thr Gly Ser Asn Ser 
                85                  90                  95      


Ile Ala Asp Leu Asn Arg Ala Val Asp Tyr Trp Ile Glu Met Lys Asp 
            100                 105                 110         


Ala Leu Ile Gly Lys Glu Asp Arg Val Ile Ile Asn Ile Ala Asn Glu 
        115                 120                 125             


Trp Tyr Gly Ala Trp Asp Gly Gln Gly Trp Ala Asn Gly Tyr Lys Glu 
    130                 135                 140                 


Val Ile Pro Arg Leu Arg Asn Ala Gly Phe Thr His Thr Leu Met Val 
145                 150                 155                 160 


Asp Ala Ala Gly Trp Gly Gln Tyr Pro Gln Ser Ile His Asp Tyr Gly 
                165                 170                 175     


Gln Glu Val Phe Asn Ala Asp Pro Leu Ala Asn Thr Met Phe Ser Ile 
            180                 185                 190         


His Met Tyr Glu Tyr Ala Gly Gly Asn Ala Ala Met Val Gln Ser Asn 
        195                 200                 205             


Ile Asp Gly Val Val Asp Gln Gly Leu Ala Leu Val Ile Gly Glu Phe 
    210                 215                 220                 


Gly His Met His Thr Asp Gly Asp Val Asp Glu Ala Thr Ile Leu Ser 
225                 230                 235                 240 


Tyr Ser Gln Gln Arg Gln Val Gly Trp Leu Ala Trp Ser Trp Lys Gly 
                245                 250                 255     


Asn Gly Ala Gln Trp Glu Tyr Leu Asp Leu Ser Tyr Asp Trp Gln Gly 
            260                 265                 270         


Thr Asn Leu Thr Ser Trp Gly Asn Thr Ile Val His Gly Pro Asn Gly 
        275                 280                 285             


Leu Lys Glu Thr Ser Ile Pro Ser Ser Ile Phe His Thr Ala Pro Asn 
    290                 295                 300                 


Asn Gly Asp Pro Pro Pro His Asn Gly Asn Glu Thr Ile Leu Tyr Asp 
305                 310                 315                 320 


Phe Glu His Gly Thr Gln Gly Trp Ser Gly Ser Ser Leu Leu Gly Gly 
                325                 330                 335     


Pro Trp Thr Thr Asn Glu Trp Ser Thr Asn Gly Asn His Ser Leu Lys 
            340                 345                 350         


Ala Asp Ile Phe Leu Ser Ala Asn Ser Lys His Glu Leu Ala Lys Val 
        355                 360                 365             


Glu Asn Arg Asn Leu Ser Gly Tyr Ser Thr Leu Gln Ala Thr Val Arg 
    370                 375                 380                 


His Ala His Trp Gly Asn Val Gly Asn Leu Thr Ala Arg Met Tyr Val 
385                 390                 395                 400 


Lys Thr Gly Ser Asn Tyr Ser Trp Phe Asn Gly Asp Pro Ile Pro Val 
                405                 410                 415     


Asn Ser Ala Asn Gly Thr Thr Val Thr Leu Pro Leu Ser Ser Ile Pro 
            420                 425                 430         


Asn Leu Asn Asp Val Lys Glu Ile Gly Val Glu Phe Ile Gly Ala Ser 
        435                 440                 445             


Asn Ser Asn Gly Gln Thr Ala Ile Tyr Leu Asp His Val Thr Ile Gln 
    450                 455                 460                 


<210>  15
<211>  1395
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  variant

<400>  15
cagacccact ccggcttcta catcgagggc agcacgctct acgacgctaa cggcgagcct       60

tttgtcatgc gcggcatcaa ccacggccac gcctggtaca agcacgactc caacgtcgcc      120

atccctgcta tcgccaacca gggcgctaac accatccgca tcgtcctcag cgacggtggc      180

cagtgggcca aggacgacat caacacgctg aaccaggtcc tcgacctggc cgaggagcac      240

gagatgatcg ctgtcgtcga ggtccacgac gctaccggca gcaactcgat ggccgacctc      300

aaccgcgccg tcgactactg gatcgagatg aaggacgccc tgatcggcaa ggaagaccgc      360

gtcatcatca acatcgccaa cgagtggtac ggcagctggg acggccaggg ctgggccaac      420

ggctacaagg aagtcatccc ccgcctgcgc aacgctggct tcacccacac cctcatggtc      480

gacgctgctg gctggggcca gtacccccag tcgatccacg actacggcca agaggtcttc      540

aacgccgacc ctctggccaa caccatgttc agcatccaca tgtacgagta cgctggcggc      600

aacgctgcta tggtccagtc gaacatcgac ggcgtcgtcg accagggcct cgctctggtc      660

atcggcgagt tcggccacat gcacacggac ggcgacgtcg acgaggctac catcctgtcc      720

tactcgcagc agcgcggcgt cggctggctc gcttggtcgt ggaagggcaa cggcgctcag      780

tgggagtacc tcgacctgtc gtacgactgg cagggcacca acctcacctc gtggggcaac      840

cgcatcgtcc acggccctaa cggcctcaaa gagacgtcga tccctagctc gatctttcac      900

accgctccta acaacggcga ccctcctccc cacaacggca acgagacgat cctgtacgac      960

ttcgagcacg gcacgcaggg ctggtcgggc tccagcctgc tgggcggccc ttggaccacc     1020

aacgagtgga gcaccaacgg caaccactcg ctcaaggccg acatcttcct gagcgccaac     1080

tcgaagcacg agctcgccaa ggtcgagaac cgcaacctct cgggctactc gacgctgcag     1140

gctaccgtcc gccacgctca ctggggcaac gtcggcaacc tgacggctcg catgtacgtc     1200

aagacgggct cgaactactc ctggttcaac ggcgacccca tccctgtcaa ctcggctaac     1260

ggcaccaccg tcaccctccc tctgagctcc atccccaacc tcaacgacgt caaggagatc     1320

ggcgtcgagt tcatcggcgc tagcaactcg aacggccaga ccgccatcta cctggaccac     1380

gtcacgatcc agtag                                                      1395


<210>  16
<211>  464
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant

<400>  16

Gln Thr His Ser Gly Phe Tyr Ile Glu Gly Ser Thr Leu Tyr Asp Ala 
1               5                   10                  15      


Asn Gly Glu Pro Phe Val Met Arg Gly Ile Asn His Gly His Ala Trp 
            20                  25                  30          


Tyr Lys His Asp Ser Asn Val Ala Ile Pro Ala Ile Ala Asn Gln Gly 
        35                  40                  45              


Ala Asn Thr Ile Arg Ile Val Leu Ser Asp Gly Gly Gln Trp Ala Lys 
    50                  55                  60                  


Asp Asp Ile Asn Thr Leu Asn Gln Val Leu Asp Leu Ala Glu Glu His 
65                  70                  75                  80  


Glu Met Ile Ala Val Val Glu Val His Asp Ala Thr Gly Ser Asn Ser 
                85                  90                  95      


Met Ala Asp Leu Asn Arg Ala Val Asp Tyr Trp Ile Glu Met Lys Asp 
            100                 105                 110         


Ala Leu Ile Gly Lys Glu Asp Arg Val Ile Ile Asn Ile Ala Asn Glu 
        115                 120                 125             


Trp Tyr Gly Ser Trp Asp Gly Gln Gly Trp Ala Asn Gly Tyr Lys Glu 
    130                 135                 140                 


Val Ile Pro Arg Leu Arg Asn Ala Gly Phe Thr His Thr Leu Met Val 
145                 150                 155                 160 


Asp Ala Ala Gly Trp Gly Gln Tyr Pro Gln Ser Ile His Asp Tyr Gly 
                165                 170                 175     


Gln Glu Val Phe Asn Ala Asp Pro Leu Ala Asn Thr Met Phe Ser Ile 
            180                 185                 190         


His Met Tyr Glu Tyr Ala Gly Gly Asn Ala Ala Met Val Gln Ser Asn 
        195                 200                 205             


Ile Asp Gly Val Val Asp Gln Gly Leu Ala Leu Val Ile Gly Glu Phe 
    210                 215                 220                 


Gly His Met His Thr Asp Gly Asp Val Asp Glu Ala Thr Ile Leu Ser 
225                 230                 235                 240 


Tyr Ser Gln Gln Arg Gly Val Gly Trp Leu Ala Trp Ser Trp Lys Gly 
                245                 250                 255     


Asn Gly Ala Gln Trp Glu Tyr Leu Asp Leu Ser Tyr Asp Trp Gln Gly 
            260                 265                 270         


Thr Asn Leu Thr Ser Trp Gly Asn Arg Ile Val His Gly Pro Asn Gly 
        275                 280                 285             


Leu Lys Glu Thr Ser Ile Pro Ser Ser Ile Phe His Thr Ala Pro Asn 
    290                 295                 300                 


Asn Gly Asp Pro Pro Pro His Asn Gly Asn Glu Thr Ile Leu Tyr Asp 
305                 310                 315                 320 


Phe Glu His Gly Thr Gln Gly Trp Ser Gly Ser Ser Leu Leu Gly Gly 
                325                 330                 335     


Pro Trp Thr Thr Asn Glu Trp Ser Thr Asn Gly Asn His Ser Leu Lys 
            340                 345                 350         


Ala Asp Ile Phe Leu Ser Ala Asn Ser Lys His Glu Leu Ala Lys Val 
        355                 360                 365             


Glu Asn Arg Asn Leu Ser Gly Tyr Ser Thr Leu Gln Ala Thr Val Arg 
    370                 375                 380                 


His Ala His Trp Gly Asn Val Gly Asn Leu Thr Ala Arg Met Tyr Val 
385                 390                 395                 400 


Lys Thr Gly Ser Asn Tyr Ser Trp Phe Asn Gly Asp Pro Ile Pro Val 
                405                 410                 415     


Asn Ser Ala Asn Gly Thr Thr Val Thr Leu Pro Leu Ser Ser Ile Pro 
            420                 425                 430         


Asn Leu Asn Asp Val Lys Glu Ile Gly Val Glu Phe Ile Gly Ala Ser 
        435                 440                 445             


Asn Ser Asn Gly Gln Thr Ala Ile Tyr Leu Asp His Val Thr Ile Gln 
    450                 455                 460                 


<210>  17
<211>  1395
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  variant

<400>  17
cagacccact ccggcttcta catcgagggc agcacgctct acgacgctaa cggcgagcct       60

tttgtcatgc gcggcatcaa ccacggccac gcctggtaca agcacgactc caacgtcgcc      120

atccctgcta tcgccaacca gggcgctaac accatccgca tcgtcctcag cgacggtggc      180

cagtgggcca aggacgacat caacacgctg aaccaggtcc tcgacctggc cgaggagcac      240

gagatgatcg ctgtcgtcga ggtccacgac gctaccggca gcaactcgat ggccgacctc      300

aaccgcgccg tcgactactg gatcgagatg aaggacgccc tgatcggcaa ggaagaccgc      360

gtcatcatca acatcgccaa cgagtggtac ggcgcttggg acggccaggg ctgggccaac      420

ggctacaagg aagtcatccc ccgcctgcgc aacgctggct tgacccacac cctcatggtc      480

gacgctgctg gctggggcca gtacccccag agcatccacg actacggcca agaggtcttc      540

aacgccgacc ctctcgccaa caccatgttc agcatccaca tgtacgagta cgctggcggc      600

aacgctgcta tggtccagtc gaacatcgac ggcgtcgtcg accagggcct cgctctggtc      660

atcggcgagt tcggccacat gcacacggac ggcgacgtcg acgaggctac catcctgtcc      720

tactcgcagc agcgcggcgt cggctggctc gcttggagct ggaagggcaa cggcgctcag      780

tgggagtacc tcgacctgtc gtacgactgg cagggcacca acctcacgtc ctggggcaac      840

accatcgtcc acggccctaa cggcctgaag gagacgtcga tccctagctc gatctttcac      900

accgctccta acaacggcga ccctcctccc cacaacggca acgagacgat cctgtacgac      960

ttcgagcacg gcacgcaggg ctggtcgggc tccagcctgc tgggcggccc ttggaccacc     1020

aacgagtgga gcacgaacgg caaccactcg ctcaaggccg acatcttcct gagcgccaac     1080

tcgaagcacg agctcgccaa ggtcgagaac cgcaacctct cgggctactc gacgctgcag     1140

gctaccgtcc gccacgctca ctggggcaac gtcggcaacc tgacggctcg catgtacgtc     1200

aagacgggct cgaactactc ctggttcaac ggcgacccca tccctgtcaa ctcggctaac     1260

ggcaccaccg tcaccctccc tctgagctcc atccccaacc tcaacgacgt caaggagatc     1320

ggcgtcgagt tcatcggcgc tagcaactcg aacggccaga ccgccatcta cctggaccac     1380

gtcacgatcc agtag                                                      1395


<210>  18
<211>  464
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant

<400>  18

Gln Thr His Ser Gly Phe Tyr Ile Glu Gly Ser Thr Leu Tyr Asp Ala 
1               5                   10                  15      


Asn Gly Glu Pro Phe Val Met Arg Gly Ile Asn His Gly His Ala Trp 
            20                  25                  30          


Tyr Lys His Asp Ser Asn Val Ala Ile Pro Ala Ile Ala Asn Gln Gly 
        35                  40                  45              


Ala Asn Thr Ile Arg Ile Val Leu Ser Asp Gly Gly Gln Trp Ala Lys 
    50                  55                  60                  


Asp Asp Ile Asn Thr Leu Asn Gln Val Leu Asp Leu Ala Glu Glu His 
65                  70                  75                  80  


Glu Met Ile Ala Val Val Glu Val His Asp Ala Thr Gly Ser Asn Ser 
                85                  90                  95      


Met Ala Asp Leu Asn Arg Ala Val Asp Tyr Trp Ile Glu Met Lys Asp 
            100                 105                 110         


Ala Leu Ile Gly Lys Glu Asp Arg Val Ile Ile Asn Ile Ala Asn Glu 
        115                 120                 125             


Trp Tyr Gly Ala Trp Asp Gly Gln Gly Trp Ala Asn Gly Tyr Lys Glu 
    130                 135                 140                 


Val Ile Pro Arg Leu Arg Asn Ala Gly Leu Thr His Thr Leu Met Val 
145                 150                 155                 160 


Asp Ala Ala Gly Trp Gly Gln Tyr Pro Gln Ser Ile His Asp Tyr Gly 
                165                 170                 175     


Gln Glu Val Phe Asn Ala Asp Pro Leu Ala Asn Thr Met Phe Ser Ile 
            180                 185                 190         


His Met Tyr Glu Tyr Ala Gly Gly Asn Ala Ala Met Val Gln Ser Asn 
        195                 200                 205             


Ile Asp Gly Val Val Asp Gln Gly Leu Ala Leu Val Ile Gly Glu Phe 
    210                 215                 220                 


Gly His Met His Thr Asp Gly Asp Val Asp Glu Ala Thr Ile Leu Ser 
225                 230                 235                 240 


Tyr Ser Gln Gln Arg Gly Val Gly Trp Leu Ala Trp Ser Trp Lys Gly 
                245                 250                 255     


Asn Gly Ala Gln Trp Glu Tyr Leu Asp Leu Ser Tyr Asp Trp Gln Gly 
            260                 265                 270         


Thr Asn Leu Thr Ser Trp Gly Asn Thr Ile Val His Gly Pro Asn Gly 
        275                 280                 285             


Leu Lys Glu Thr Ser Ile Pro Ser Ser Ile Phe His Thr Ala Pro Asn 
    290                 295                 300                 


Asn Gly Asp Pro Pro Pro His Asn Gly Asn Glu Thr Ile Leu Tyr Asp 
305                 310                 315                 320 


Phe Glu His Gly Thr Gln Gly Trp Ser Gly Ser Ser Leu Leu Gly Gly 
                325                 330                 335     


Pro Trp Thr Thr Asn Glu Trp Ser Thr Asn Gly Asn His Ser Leu Lys 
            340                 345                 350         


Ala Asp Ile Phe Leu Ser Ala Asn Ser Lys His Glu Leu Ala Lys Val 
        355                 360                 365             


Glu Asn Arg Asn Leu Ser Gly Tyr Ser Thr Leu Gln Ala Thr Val Arg 
    370                 375                 380                 


His Ala His Trp Gly Asn Val Gly Asn Leu Thr Ala Arg Met Tyr Val 
385                 390                 395                 400 


Lys Thr Gly Ser Asn Tyr Ser Trp Phe Asn Gly Asp Pro Ile Pro Val 
                405                 410                 415     


Asn Ser Ala Asn Gly Thr Thr Val Thr Leu Pro Leu Ser Ser Ile Pro 
            420                 425                 430         


Asn Leu Asn Asp Val Lys Glu Ile Gly Val Glu Phe Ile Gly Ala Ser 
        435                 440                 445             


Asn Ser Asn Gly Gln Thr Ala Ile Tyr Leu Asp His Val Thr Ile Gln 
    450                 455                 460                 


<210>  19
<211>  1395
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  variant

<400>  19
cagacccact ccggcttcta catcgagggc agcacgctct acgacgctaa cggcgagcct       60

tttgtcatgc gcggcatcaa ccacggccac gcctggtaca agcacgactc caacgtcgcc      120

atccctgcta tcgccaacca gggcgctaac accatccgca tcgtcctcag cgacggtggc      180

cagtgggcca aggacgacat caacacgctg aaccaggtcc tcgacctggc cgaggagcac      240

gagatgatcg ctgtcgtcga ggtccacgac gctaccggca gcaactcgat ggccgacctc      300

aaccgcgccg tcgactactg gatcgagatg aaggacgccc tgatcggcaa ggaagaccgc      360

gtcatcatca acatcgccaa cgagtggtac ggcgcttggg acggccaggg ctgggccaac      420

ggctacaagg aagtcatccc ccgcctgcgc aacgctggct tcacccacac cctcatggtc      480

gacgctgctg gctggggcca gtacccccag agcatccacg actacggcca agaggtcttc      540

aacgccgacc ctctcgccaa caccatgttc agcatccaca tgtacgagta cgctggcggc      600

aacgctgcta tggtccagtc gaacatcgac ggcgtcgtcg accagggcct cgctctggtc      660

atcggcgagt tcggccacat gcacacggac ggcgacgtcg acgaggctac catcctgtcc      720

tactcgcagc agcgcggcgt cggctggctc gcttggagct ggaagggcaa cggcgctcag      780

tgggagtacc tcgacctgtc gtacgactgg cagggcacca acctcacgtc ctggggcaac      840

accatcgtcc acggccctaa cggcctgttg gagacgtcga tccctagctc gatctttcac      900

accgctccta acaacggcga ccctcctccc cacaacggca acgagacgat cctgtacgac      960

ttcgagcacg gcacgcaggg ctggtcgggc tccagcctgc tgggcggccc ttggaccacc     1020

aacgagtgga gcacgaacgg caaccactcg ctcaaggccg acatcttcct gagcgccaac     1080

tcgaagcacg agctcgccaa ggtcgagaac cgcaacctct cgggctactc gacgctgcag     1140

gctaccgtcc gccacgctca ctggggcaac gtcggcaacc tgacggctcg catgtacgtc     1200

aagacgggct cgaactactc ctggttcaac ggcgacccca tccctgtcaa ctcggctaac     1260

ggcaccaccg tcaccctccc tctgagctcc atccccaacc tcaacgacgt caaggagatc     1320

ggcgtcgagt tcatcggcgc tagcaactcg aacggccaga ccgccatcta cctggaccac     1380

gtcacgatcc agtag                                                      1395


<210>  20
<211>  464
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant

<400>  20

Gln Thr His Ser Gly Phe Tyr Ile Glu Gly Ser Thr Leu Tyr Asp Ala 
1               5                   10                  15      


Asn Gly Glu Pro Phe Val Met Arg Gly Ile Asn His Gly His Ala Trp 
            20                  25                  30          


Tyr Lys His Asp Ser Asn Val Ala Ile Pro Ala Ile Ala Asn Gln Gly 
        35                  40                  45              


Ala Asn Thr Ile Arg Ile Val Leu Ser Asp Gly Gly Gln Trp Ala Lys 
    50                  55                  60                  


Asp Asp Ile Asn Thr Leu Asn Gln Val Leu Asp Leu Ala Glu Glu His 
65                  70                  75                  80  


Glu Met Ile Ala Val Val Glu Val His Asp Ala Thr Gly Ser Asn Ser 
                85                  90                  95      


Met Ala Asp Leu Asn Arg Ala Val Asp Tyr Trp Ile Glu Met Lys Asp 
            100                 105                 110         


Ala Leu Ile Gly Lys Glu Asp Arg Val Ile Ile Asn Ile Ala Asn Glu 
        115                 120                 125             


Trp Tyr Gly Ala Trp Asp Gly Gln Gly Trp Ala Asn Gly Tyr Lys Glu 
    130                 135                 140                 


Val Ile Pro Arg Leu Arg Asn Ala Gly Phe Thr His Thr Leu Met Val 
145                 150                 155                 160 


Asp Ala Ala Gly Trp Gly Gln Tyr Pro Gln Ser Ile His Asp Tyr Gly 
                165                 170                 175     


Gln Glu Val Phe Asn Ala Asp Pro Leu Ala Asn Thr Met Phe Ser Ile 
            180                 185                 190         


His Met Tyr Glu Tyr Ala Gly Gly Asn Ala Ala Met Val Gln Ser Asn 
        195                 200                 205             


Ile Asp Gly Val Val Asp Gln Gly Leu Ala Leu Val Ile Gly Glu Phe 
    210                 215                 220                 


Gly His Met His Thr Asp Gly Asp Val Asp Glu Ala Thr Ile Leu Ser 
225                 230                 235                 240 


Tyr Ser Gln Gln Arg Gly Val Gly Trp Leu Ala Trp Ser Trp Lys Gly 
                245                 250                 255     


Asn Gly Ala Gln Trp Glu Tyr Leu Asp Leu Ser Tyr Asp Trp Gln Gly 
            260                 265                 270         


Thr Asn Leu Thr Ser Trp Gly Asn Thr Ile Val His Gly Pro Asn Gly 
        275                 280                 285             


Leu Leu Glu Thr Ser Ile Pro Ser Ser Ile Phe His Thr Ala Pro Asn 
    290                 295                 300                 


Asn Gly Asp Pro Pro Pro His Asn Gly Asn Glu Thr Ile Leu Tyr Asp 
305                 310                 315                 320 


Phe Glu His Gly Thr Gln Gly Trp Ser Gly Ser Ser Leu Leu Gly Gly 
                325                 330                 335     


Pro Trp Thr Thr Asn Glu Trp Ser Thr Asn Gly Asn His Ser Leu Lys 
            340                 345                 350         


Ala Asp Ile Phe Leu Ser Ala Asn Ser Lys His Glu Leu Ala Lys Val 
        355                 360                 365             


Glu Asn Arg Asn Leu Ser Gly Tyr Ser Thr Leu Gln Ala Thr Val Arg 
    370                 375                 380                 


His Ala His Trp Gly Asn Val Gly Asn Leu Thr Ala Arg Met Tyr Val 
385                 390                 395                 400 


Lys Thr Gly Ser Asn Tyr Ser Trp Phe Asn Gly Asp Pro Ile Pro Val 
                405                 410                 415     


Asn Ser Ala Asn Gly Thr Thr Val Thr Leu Pro Leu Ser Ser Ile Pro 
            420                 425                 430         


Asn Leu Asn Asp Val Lys Glu Ile Gly Val Glu Phe Ile Gly Ala Ser 
        435                 440                 445             


Asn Ser Asn Gly Gln Thr Ala Ile Tyr Leu Asp His Val Thr Ile Gln 
    450                 455                 460                 


<210>  21
<211>  1395
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  variant

<400>  21
cagacccact cgggcttcta catcgagggc tccacgctct acgacgctaa cggcgagcct       60

tttgtcatgc gcggcatcaa ccacggccac gcctggtaca agcacgacag caacgtcgcc      120

atccctgcta tcgccaacca gggcgctaac accatccgca tcgtcctctc ggacggtggc      180

cagtgggcca aggacgacat caacacgctg aaccaggtcc tcgacctggc cgaggagcac      240

gagatgatcg ctgtcgtcga ggtccacgac gctaccggca gcaactcgat ggccgacctc      300

aaccgcgccg tcgactactg gatcgagatg aaggacgccc tgatcggcaa ggaagaccgc      360

gtcatcatca acatcgccaa cgagtggtac ggcgcttggg acggccaggg ctgggccaac      420

ggctacaagg aagtcatccc ccgcctgcgc aacgctggct tcacccacac cctcatggtc      480

gacgctgctg gctggggcca gtacccccag tcgatccacg actacggcca agaggtcttc      540

aacgccgacc ctctggccaa caccatgttc tcgatccaca tgtacgagta cgctggcggc      600

aacgctgcta tggtccagtc caacatcgac ggcgtcgtcg accagggcct cgctctggtc      660

atcggcgagt tcggccacat gcacacggac ggcgacgtcg acgaggctac catcctgtcc      720

tactcgcagc agcgcggcgt cggctggctc gcttggtcgt ggaagggcaa cggcgctcag      780

tgggagtacc tcgacctgag ctacgactgg cagggcaccc agctcaccag ctggggcaac      840

accatcgtcc acggccctaa cggcctcctg gagacgtcca tccctagctc gatctttcac      900

accgctccta acaacggcga ccctcctccc cacaacggcc aggagacgat cctgtacgac      960

ttcgagcacg gcacgcaggg ctggtcgggc tccagcctgc tgggcggccc ttggaccacc     1020

aacgagtggt ccacgaacgg caaccacagc ctcaaggccg acatcttcct gagcgccaac     1080

tcgaagcacg agctcgccaa ggtcgagaac cgcaacctgg ctggctactc gacgctgcag     1140

gctaccgtcc gccacgctca ctggggcaac gtcggcgctc tgacggctcg catgtacgtc     1200

aagacgggct ccaactacgc ctggttcaac ggcgacccca tccctgtcaa ctcggctcag     1260

ggcaccaccg tcaccctccc tctgagctcc atccccaacc tcaacgacgt caaggagatc     1320

ggcgtcgagt tcatcggcgc tagcaactcg aacggccaga ccgccatcta cctggaccac     1380

gtcacgatcc agtag                                                      1395


<210>  22
<211>  464
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant

<400>  22

Gln Thr His Ser Gly Phe Tyr Ile Glu Gly Ser Thr Leu Tyr Asp Ala 
1               5                   10                  15      


Asn Gly Glu Pro Phe Val Met Arg Gly Ile Asn His Gly His Ala Trp 
            20                  25                  30          


Tyr Lys His Asp Ser Asn Val Ala Ile Pro Ala Ile Ala Asn Gln Gly 
        35                  40                  45              


Ala Asn Thr Ile Arg Ile Val Leu Ser Asp Gly Gly Gln Trp Ala Lys 
    50                  55                  60                  


Asp Asp Ile Asn Thr Leu Asn Gln Val Leu Asp Leu Ala Glu Glu His 
65                  70                  75                  80  


Glu Met Ile Ala Val Val Glu Val His Asp Ala Thr Gly Ser Asn Ser 
                85                  90                  95      


Met Ala Asp Leu Asn Arg Ala Val Asp Tyr Trp Ile Glu Met Lys Asp 
            100                 105                 110         


Ala Leu Ile Gly Lys Glu Asp Arg Val Ile Ile Asn Ile Ala Asn Glu 
        115                 120                 125             


Trp Tyr Gly Ala Trp Asp Gly Gln Gly Trp Ala Asn Gly Tyr Lys Glu 
    130                 135                 140                 


Val Ile Pro Arg Leu Arg Asn Ala Gly Phe Thr His Thr Leu Met Val 
145                 150                 155                 160 


Asp Ala Ala Gly Trp Gly Gln Tyr Pro Gln Ser Ile His Asp Tyr Gly 
                165                 170                 175     


Gln Glu Val Phe Asn Ala Asp Pro Leu Ala Asn Thr Met Phe Ser Ile 
            180                 185                 190         


His Met Tyr Glu Tyr Ala Gly Gly Asn Ala Ala Met Val Gln Ser Asn 
        195                 200                 205             


Ile Asp Gly Val Val Asp Gln Gly Leu Ala Leu Val Ile Gly Glu Phe 
    210                 215                 220                 


Gly His Met His Thr Asp Gly Asp Val Asp Glu Ala Thr Ile Leu Ser 
225                 230                 235                 240 


Tyr Ser Gln Gln Arg Gly Val Gly Trp Leu Ala Trp Ser Trp Lys Gly 
                245                 250                 255     


Asn Gly Ala Gln Trp Glu Tyr Leu Asp Leu Ser Tyr Asp Trp Gln Gly 
            260                 265                 270         


Thr Gln Leu Thr Ser Trp Gly Asn Thr Ile Val His Gly Pro Asn Gly 
        275                 280                 285             


Leu Leu Glu Thr Ser Ile Pro Ser Ser Ile Phe His Thr Ala Pro Asn 
    290                 295                 300                 


Asn Gly Asp Pro Pro Pro His Asn Gly Gln Glu Thr Ile Leu Tyr Asp 
305                 310                 315                 320 


Phe Glu His Gly Thr Gln Gly Trp Ser Gly Ser Ser Leu Leu Gly Gly 
                325                 330                 335     


Pro Trp Thr Thr Asn Glu Trp Ser Thr Asn Gly Asn His Ser Leu Lys 
            340                 345                 350         


Ala Asp Ile Phe Leu Ser Ala Asn Ser Lys His Glu Leu Ala Lys Val 
        355                 360                 365             


Glu Asn Arg Asn Leu Ala Gly Tyr Ser Thr Leu Gln Ala Thr Val Arg 
    370                 375                 380                 


His Ala His Trp Gly Asn Val Gly Ala Leu Thr Ala Arg Met Tyr Val 
385                 390                 395                 400 


Lys Thr Gly Ser Asn Tyr Ala Trp Phe Asn Gly Asp Pro Ile Pro Val 
                405                 410                 415     


Asn Ser Ala Gln Gly Thr Thr Val Thr Leu Pro Leu Ser Ser Ile Pro 
            420                 425                 430         


Asn Leu Asn Asp Val Lys Glu Ile Gly Val Glu Phe Ile Gly Ala Ser 
        435                 440                 445             


Asn Ser Asn Gly Gln Thr Ala Ile Tyr Leu Asp His Val Thr Ile Gln 
    450                 455                 460                 


<210>  23
<211>  1395
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  variant

<400>  23
cagacccact ccggcttcta catcgagggc agcacgctct acgacgctaa cggcgagcct       60

tttgtcatgc gcggcatcaa ccacggccac gcctggtaca agcacgactc caacgtcgcc      120

atccctgcta tcgccaacca gggcgctaac accatccgca tcgtcctcag cgacggtggc      180

cagtgggcca aggacgacat caacacgctg aaccaggtcc tcgacctggc cgaggagcac      240

gagatgatcg ctgtcgtcga ggtccacgac gctaccggca gcaactcgat ggccgacctc      300

aaccgcgccg tcgactactg gatcgagatg aaggacgccc tgatcggcaa ggaagaccgc      360

gtcatcatca acatcgccaa cgagtggtac ggcagctggg acggccaggg ctgggccaac      420

ggctacaagg aagtcatccc ccgcctgcgc aacgctggct tcacccacac cctcatggtc      480

gacgctgctg gctggggcca gtacccccag tcgatccacg actacggcca agaggtcttc      540

aacgccgacc ctctggccaa caccatgttc agcatccaca tgtacgagta cgctggcggc      600

aacgctgcta tggtccagtc gaacatcgac ggcgtcgtcg accagggcct cgctctggtc      660

atcggcgagt tcggccacat gcacacggac ggcgacgtcg acgaggctac catcctgtcc      720

tactcgcagc agcgcggcgt cggctggctc gcttggtcgt ggaagggcaa cggcacgcag      780

tgggagtacc tcgacctgtc gtacgactgg cagggcacca acctcacctc gtggggcaac      840

cgcatcgtcc acggccctaa cggcctcaaa gagacgtcga tccctagctc gatctttcac      900

accgctccta acaacggcga ccctcctccc cacaacggca acgagacgat cctgtacgac      960

ttcgagcacg gcacgcaggg ctggtcgggc tccagcctgc tgggcggccc ttggaccacc     1020

aacgagtgga gcaccaacgg caaccactcg ctcaaggccg acatcttcct gagcgccaac     1080

tcgaagcacg agctcgccaa ggtcgagaac cgcaacctct cgggctactc gacgctgcag     1140

gctaccgtcc gccacgctca ctggggcaac gtcggcaacc tgacggctcg catgtacgtc     1200

aagacgggct cgaactactc ctggttcaac ggcgacccca tccctgtcaa ctcggctaac     1260

ggcaccaccg tcaccctccc tctgagctcc atccccaacc tcaacgacgt caaggagatc     1320

ggcgtcgagt tcatcggcgc tagcaactcg aacggccaga ccgccatcta cctggaccac     1380

gtcacgatcc agtag                                                      1395


<210>  24
<211>  464
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant

<400>  24

Gln Thr His Ser Gly Phe Tyr Ile Glu Gly Ser Thr Leu Tyr Asp Ala 
1               5                   10                  15      


Asn Gly Glu Pro Phe Val Met Arg Gly Ile Asn His Gly His Ala Trp 
            20                  25                  30          


Tyr Lys His Asp Ser Asn Val Ala Ile Pro Ala Ile Ala Asn Gln Gly 
        35                  40                  45              


Ala Asn Thr Ile Arg Ile Val Leu Ser Asp Gly Gly Gln Trp Ala Lys 
    50                  55                  60                  


Asp Asp Ile Asn Thr Leu Asn Gln Val Leu Asp Leu Ala Glu Glu His 
65                  70                  75                  80  


Glu Met Ile Ala Val Val Glu Val His Asp Ala Thr Gly Ser Asn Ser 
                85                  90                  95      


Met Ala Asp Leu Asn Arg Ala Val Asp Tyr Trp Ile Glu Met Lys Asp 
            100                 105                 110         


Ala Leu Ile Gly Lys Glu Asp Arg Val Ile Ile Asn Ile Ala Asn Glu 
        115                 120                 125             


Trp Tyr Gly Ser Trp Asp Gly Gln Gly Trp Ala Asn Gly Tyr Lys Glu 
    130                 135                 140                 


Val Ile Pro Arg Leu Arg Asn Ala Gly Phe Thr His Thr Leu Met Val 
145                 150                 155                 160 


Asp Ala Ala Gly Trp Gly Gln Tyr Pro Gln Ser Ile His Asp Tyr Gly 
                165                 170                 175     


Gln Glu Val Phe Asn Ala Asp Pro Leu Ala Asn Thr Met Phe Ser Ile 
            180                 185                 190         


His Met Tyr Glu Tyr Ala Gly Gly Asn Ala Ala Met Val Gln Ser Asn 
        195                 200                 205             


Ile Asp Gly Val Val Asp Gln Gly Leu Ala Leu Val Ile Gly Glu Phe 
    210                 215                 220                 


Gly His Met His Thr Asp Gly Asp Val Asp Glu Ala Thr Ile Leu Ser 
225                 230                 235                 240 


Tyr Ser Gln Gln Arg Gly Val Gly Trp Leu Ala Trp Ser Trp Lys Gly 
                245                 250                 255     


Asn Gly Thr Gln Trp Glu Tyr Leu Asp Leu Ser Tyr Asp Trp Gln Gly 
            260                 265                 270         


Thr Asn Leu Thr Ser Trp Gly Asn Arg Ile Val His Gly Pro Asn Gly 
        275                 280                 285             


Leu Lys Glu Thr Ser Ile Pro Ser Ser Ile Phe His Thr Ala Pro Asn 
    290                 295                 300                 


Asn Gly Asp Pro Pro Pro His Asn Gly Asn Glu Thr Ile Leu Tyr Asp 
305                 310                 315                 320 


Phe Glu His Gly Thr Gln Gly Trp Ser Gly Ser Ser Leu Leu Gly Gly 
                325                 330                 335     


Pro Trp Thr Thr Asn Glu Trp Ser Thr Asn Gly Asn His Ser Leu Lys 
            340                 345                 350         


Ala Asp Ile Phe Leu Ser Ala Asn Ser Lys His Glu Leu Ala Lys Val 
        355                 360                 365             


Glu Asn Arg Asn Leu Ser Gly Tyr Ser Thr Leu Gln Ala Thr Val Arg 
    370                 375                 380                 


His Ala His Trp Gly Asn Val Gly Asn Leu Thr Ala Arg Met Tyr Val 
385                 390                 395                 400 


Lys Thr Gly Ser Asn Tyr Ser Trp Phe Asn Gly Asp Pro Ile Pro Val 
                405                 410                 415     


Asn Ser Ala Asn Gly Thr Thr Val Thr Leu Pro Leu Ser Ser Ile Pro 
            420                 425                 430         


Asn Leu Asn Asp Val Lys Glu Ile Gly Val Glu Phe Ile Gly Ala Ser 
        435                 440                 445             


Asn Ser Asn Gly Gln Thr Ala Ile Tyr Leu Asp His Val Thr Ile Gln 
    450                 455                 460                 


<210>  25
<211>  1395
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  variant

<400>  25
cagacccact ccggcttcta catcgagggc agcacgctct acgacgctaa cggcgagcct       60

tttgtcatgc gcggcatcaa ccacggccac gcctggtaca agcacgactc caacgtcgcc      120

atccctgcta tcgccaacca gggcgctaac accatccgca tcgtcctcag cgacggtggc      180

cagtgggcca aggacgacat caacacgctg aaccaggtcc tcgacctggc cgaggagcac      240

gagatgatcg ctgtcgtcga ggtccacgac gctaccggca gcaactcgat ggccgacctc      300

aaccgcgccg tcgactactg gatcgagatg aaggacgccc tgatcggcaa ggaagaccgc      360

gtcatcatca acatcgccaa cgagtggtac ggcagctggg acggccaggg ctgggccaac      420

ggctacaagg aagtcatccc ccgcctgcgc aacgctggct tcacccacac cctcatggtc      480

gacgctgctg gctggggcca gtacccccag tcgatccacg actacggcca agaggtcttc      540

aacgccgacc ctctggccaa caccatgttc agcatccaca tgtacgagta cgctggcggc      600

aacgcttcga tggtccagtc gaacatcgac ggcgtcgtcg accagggcct cgctctggtc      660

atcggcgagt tcggccacat gcacacggac ggcgacgtcg acgaggctac catcctgtcc      720

tactcgcagc agcgcggcgt cggctggctc gcttggtcgt ggaagggcaa cggcgctcag      780

tgggagtacc tcgacctgtc gtacgactgg cagggcacca acctcacctc gtggggcaac      840

cgcatcgtcc acggccctaa cggcctcaaa gagacgtcga tccctagctc gatctttcac      900

accgctccta acaacggcga ccctcctccc cacaacggca acgagacgat cctgtacgac      960

ttcgagcacg gcacgcaggg ctggtcgggc tccagcctgc tgggcggccc ttggaccacc     1020

aacgagtgga gcaccaacgg caaccactcg ctcaaggccg acatcttcct gagcgccaac     1080

tcgaagcacg agctcgccaa ggtcgagaac cgcaacctct cgggctactc gacgctgcag     1140

gctaccgtcc gccacgctca ctggggcaac gtcggcaacc tgacggctcg catgtacgtc     1200

aagacgggct cgaactactc ctggttcaac ggcgacccca tccctgtcaa ctcggctaac     1260

ggcaccaccg tcaccctccc tctgagctcc atccccaacc tcaacgacgt caaggagatc     1320

ggcgtcgagt tcatcggcgc tagcaactcg aacggccaga ccgccatcta cctggaccac     1380

gtcacgatcc agtag                                                      1395


<210>  26
<211>  464
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant

<400>  26

Gln Thr His Ser Gly Phe Tyr Ile Glu Gly Ser Thr Leu Tyr Asp Ala 
1               5                   10                  15      


Asn Gly Glu Pro Phe Val Met Arg Gly Ile Asn His Gly His Ala Trp 
            20                  25                  30          


Tyr Lys His Asp Ser Asn Val Ala Ile Pro Ala Ile Ala Asn Gln Gly 
        35                  40                  45              


Ala Asn Thr Ile Arg Ile Val Leu Ser Asp Gly Gly Gln Trp Ala Lys 
    50                  55                  60                  


Asp Asp Ile Asn Thr Leu Asn Gln Val Leu Asp Leu Ala Glu Glu His 
65                  70                  75                  80  


Glu Met Ile Ala Val Val Glu Val His Asp Ala Thr Gly Ser Asn Ser 
                85                  90                  95      


Met Ala Asp Leu Asn Arg Ala Val Asp Tyr Trp Ile Glu Met Lys Asp 
            100                 105                 110         


Ala Leu Ile Gly Lys Glu Asp Arg Val Ile Ile Asn Ile Ala Asn Glu 
        115                 120                 125             


Trp Tyr Gly Ser Trp Asp Gly Gln Gly Trp Ala Asn Gly Tyr Lys Glu 
    130                 135                 140                 


Val Ile Pro Arg Leu Arg Asn Ala Gly Phe Thr His Thr Leu Met Val 
145                 150                 155                 160 


Asp Ala Ala Gly Trp Gly Gln Tyr Pro Gln Ser Ile His Asp Tyr Gly 
                165                 170                 175     


Gln Glu Val Phe Asn Ala Asp Pro Leu Ala Asn Thr Met Phe Ser Ile 
            180                 185                 190         


His Met Tyr Glu Tyr Ala Gly Gly Asn Ala Ser Met Val Gln Ser Asn 
        195                 200                 205             


Ile Asp Gly Val Val Asp Gln Gly Leu Ala Leu Val Ile Gly Glu Phe 
    210                 215                 220                 


Gly His Met His Thr Asp Gly Asp Val Asp Glu Ala Thr Ile Leu Ser 
225                 230                 235                 240 


Tyr Ser Gln Gln Arg Gly Val Gly Trp Leu Ala Trp Ser Trp Lys Gly 
                245                 250                 255     


Asn Gly Ala Gln Trp Glu Tyr Leu Asp Leu Ser Tyr Asp Trp Gln Gly 
            260                 265                 270         


Thr Asn Leu Thr Ser Trp Gly Asn Arg Ile Val His Gly Pro Asn Gly 
        275                 280                 285             


Leu Lys Glu Thr Ser Ile Pro Ser Ser Ile Phe His Thr Ala Pro Asn 
    290                 295                 300                 


Asn Gly Asp Pro Pro Pro His Asn Gly Asn Glu Thr Ile Leu Tyr Asp 
305                 310                 315                 320 


Phe Glu His Gly Thr Gln Gly Trp Ser Gly Ser Ser Leu Leu Gly Gly 
                325                 330                 335     


Pro Trp Thr Thr Asn Glu Trp Ser Thr Asn Gly Asn His Ser Leu Lys 
            340                 345                 350         


Ala Asp Ile Phe Leu Ser Ala Asn Ser Lys His Glu Leu Ala Lys Val 
        355                 360                 365             


Glu Asn Arg Asn Leu Ser Gly Tyr Ser Thr Leu Gln Ala Thr Val Arg 
    370                 375                 380                 


His Ala His Trp Gly Asn Val Gly Asn Leu Thr Ala Arg Met Tyr Val 
385                 390                 395                 400 


Lys Thr Gly Ser Asn Tyr Ser Trp Phe Asn Gly Asp Pro Ile Pro Val 
                405                 410                 415     


Asn Ser Ala Asn Gly Thr Thr Val Thr Leu Pro Leu Ser Ser Ile Pro 
            420                 425                 430         


Asn Leu Asn Asp Val Lys Glu Ile Gly Val Glu Phe Ile Gly Ala Ser 
        435                 440                 445             


Asn Ser Asn Gly Gln Thr Ala Ile Tyr Leu Asp His Val Thr Ile Gln 
    450                 455                 460                 


