               SEQUENCE LISTING

<110> Merck Patent GmbH
      Ablynx N.V.

<120> Polypeptides binding ADAMTS5, MMP13 and Aggrecan

<130> MEPAT.0105

<150> EP17174404.8
<151> 2017-06-02

<160> 68

<170> BiSSAP 1.3.6

<210> 1
<211> 593
<212> PRT
<213> Artificial Sequence


<220> 
<223> Amino acid sequence

<400> 1
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ala Phe Ser Ala Ala 
            20                  25                  30          
Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ser Ser Ile Ser Asp Asp Gly Ser Lys Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      
Asn Thr Gly Tyr Gly Ala Thr Thr Thr Arg Pro Gly Arg Tyr Trp Gly 
            100                 105                 110         
Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             
Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    130                 135                 140                 
Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu 
145                 150                 155                 160 
Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly Ser Leu Arg Leu 
                165                 170                 175     
Ser Cys Ala Ala Ser Gly Arg Thr Val Ser Ser Tyr Ala Met Gly Trp 
            180                 185                 190         
Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val Ala Gly Ile Ser 
        195                 200                 205             
Arg Ser Ala Glu Arg Thr Tyr Tyr Val Asp Ser Leu Lys Gly Arg Phe 
    210                 215                 220                 
Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr Leu Gln Met Asn 
225                 230                 235                 240 
Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys Ala Ala Asp Leu 
                245                 250                 255     
Asp Pro Asn Arg Ile Phe Ser Arg Glu Glu Tyr Ala Tyr Trp Gly Gln 
            260                 265                 270         
Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        275                 280                 285             
Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    290                 295                 300                 
Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val 
305                 310                 315                 320 
Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly Ser Leu Arg Leu Ser 
                325                 330                 335     
Cys Ala Ala Ser Gly Ser Thr Phe Ile Ile Asn Val Val Arg Trp Tyr 
            340                 345                 350         
Arg Arg Ala Pro Gly Lys Gln Arg Glu Leu Val Ala Thr Ile Ser Ser 
        355                 360                 365             
Gly Gly Asn Ala Asn Tyr Val Asp Ser Val Arg Gly Arg Phe Thr Ile 
    370                 375                 380                 
Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu 
385                 390                 395                 400 
Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys Asn Val Pro Thr Thr His 
                405                 410                 415     
Tyr Gly Gly Val Tyr Tyr Gly Pro Tyr Trp Gly Gln Gly Thr Leu Val 
            420                 425                 430         
Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
        435                 440                 445             
Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    450                 455                 460                 
Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly 
465                 470                 475                 480 
Gly Val Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser 
                485                 490                 495     
Gly Ser Thr Phe Ile Ile Asn Val Val Arg Trp Tyr Arg Arg Ala Pro 
            500                 505                 510         
Gly Lys Gln Arg Glu Leu Val Ala Thr Ile Ser Ser Gly Gly Asn Ala 
        515                 520                 525             
Asn Tyr Val Asp Ser Val Arg Gly Arg Phe Thr Ile Ser Arg Asp Asn 
    530                 535                 540                 
Ser Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu Asp 
545                 550                 555                 560 
Thr Ala Leu Tyr Tyr Cys Asn Val Pro Thr Thr His Tyr Gly Gly Val 
                565                 570                 575     
Tyr Tyr Gly Pro Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
            580                 585                 590         
Ala 
    

<210> 2
<211> 121
<212> PRT
<213> Artificial Sequence


<220> 
<223> Amino acid sequence

<400> 2
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ala Phe Ser Ala Ala 
            20                  25                  30          
Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ser Ser Ile Ser Asp Asp Gly Ser Lys Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      
Asn Thr Gly Tyr Gly Ala Thr Thr Thr Arg Pro Gly Arg Tyr Trp Gly 
            100                 105                 110         
Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     

<210> 3
<211> 124
<212> PRT
<213> Artificial Sequence


<220> 
<223> Amino acid sequence

<400> 3
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Val Ser Ser Tyr 
            20                  25                  30          
Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              
Ala Gly Ile Ser Arg Ser Ala Glu Arg Thr Tyr Tyr Val Asp Ser Leu 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      
Ala Ala Asp Leu Asp Pro Asn Arg Ile Phe Ser Arg Glu Glu Tyr Ala 
            100                 105                 110         
Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 

<210> 4
<211> 121
<212> PRT
<213> Artificial Sequence


<220> 
<223> Amino acid sequence

<400> 4
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Thr Phe Ile Ile Asn 
            20                  25                  30          
Val Val Arg Trp Tyr Arg Arg Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              
Ala Thr Ile Ser Ser Gly Gly Asn Ala Asn Tyr Val Asp Ser Val Arg 
    50                  55                  60                  
Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  
Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys Asn 
                85                  90                  95      
Val Pro Thr Thr His Tyr Gly Gly Val Tyr Tyr Gly Pro Tyr Trp Gly 
            100                 105                 110         
Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     

<210> 5
<211> 434
<212> PRT
<213> Artificial Sequence


<220> 
<223> Amino acid sequence

<400> 5
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ala Phe Ser Ala Ala 
            20                  25                  30          
Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ser Ser Ile Ser Asp Asp Gly Ser Lys Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      
Asn Thr Gly Tyr Gly Ala Thr Thr Thr Arg Pro Gly Arg Tyr Trp Gly 
            100                 105                 110         
Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             
Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    130                 135                 140                 
Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu 
145                 150                 155                 160 
Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly Ser Leu Arg Leu 
                165                 170                 175     
Ser Cys Ala Ala Ser Gly Ser Thr Phe Ile Ile Asn Val Val Arg Trp 
            180                 185                 190         
Tyr Arg Arg Ala Pro Gly Lys Gln Arg Glu Leu Val Ala Thr Ile Ser 
        195                 200                 205             
Ser Gly Gly Asn Ala Asn Tyr Val Asp Ser Val Arg Gly Arg Phe Thr 
    210                 215                 220                 
Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr Leu Gln Met Asn Ser 
225                 230                 235                 240 
Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys Asn Val Pro Thr Thr 
                245                 250                 255     
His Tyr Gly Gly Val Tyr Tyr Gly Pro Tyr Trp Gly Gln Gly Thr Leu 
            260                 265                 270         
Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        275                 280                 285             
Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    290                 295                 300                 
Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly 
305                 310                 315                 320 
Gly Gly Val Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala 
                325                 330                 335     
Ser Gly Ser Thr Phe Ile Ile Asn Val Val Arg Trp Tyr Arg Arg Ala 
            340                 345                 350         
Pro Gly Lys Gln Arg Glu Leu Val Ala Thr Ile Ser Ser Gly Gly Asn 
        355                 360                 365             
Ala Asn Tyr Val Asp Ser Val Arg Gly Arg Phe Thr Ile Ser Arg Asp 
    370                 375                 380                 
Asn Ser Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu 
385                 390                 395                 400 
Asp Thr Ala Leu Tyr Tyr Cys Asn Val Pro Thr Thr His Tyr Gly Gly 
                405                 410                 415     
Val Tyr Tyr Gly Pro Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
            420                 425                 430         
Ser Ala 
        

<210> 6
<211> 437
<212> PRT
<213> Artificial Sequence


<220> 
<223> Amino acid sequence

<400> 6
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Val Ser Ser Tyr 
            20                  25                  30          
Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              
Ala Gly Ile Ser Arg Ser Ala Glu Arg Thr Tyr Tyr Val Asp Ser Leu 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      
Ala Ala Asp Leu Asp Pro Asn Arg Ile Phe Ser Arg Glu Glu Tyr Ala 
            100                 105                 110         
Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly 
        115                 120                 125             
Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu 
145                 150                 155                 160 
Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly Ser 
                165                 170                 175     
Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Thr Phe Ile Ile Asn Val 
            180                 185                 190         
Val Arg Trp Tyr Arg Arg Ala Pro Gly Lys Gln Arg Glu Leu Val Ala 
        195                 200                 205             
Thr Ile Ser Ser Gly Gly Asn Ala Asn Tyr Val Asp Ser Val Arg Gly 
    210                 215                 220                 
Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr Leu Gln 
225                 230                 235                 240 
Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys Asn Val 
                245                 250                 255     
Pro Thr Thr His Tyr Gly Gly Val Tyr Tyr Gly Pro Tyr Trp Gly Gln 
            260                 265                 270         
Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        275                 280                 285             
Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    290                 295                 300                 
Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val 
305                 310                 315                 320 
Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly Ser Leu Arg Leu Ser 
                325                 330                 335     
Cys Ala Ala Ser Gly Ser Thr Phe Ile Ile Asn Val Val Arg Trp Tyr 
            340                 345                 350         
Arg Arg Ala Pro Gly Lys Gln Arg Glu Leu Val Ala Thr Ile Ser Ser 
        355                 360                 365             
Gly Gly Asn Ala Asn Tyr Val Asp Ser Val Arg Gly Arg Phe Thr Ile 
    370                 375                 380                 
Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu 
385                 390                 395                 400 
Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys Asn Val Pro Thr Thr His 
                405                 410                 415     
Tyr Gly Gly Val Tyr Tyr Gly Pro Tyr Trp Gly Gln Gly Thr Leu Val 
            420                 425                 430         
Thr Val Ser Ser Ala 
        435         

<210> 7
<211> 25
<212> PRT
<213> Artificial Sequence


<220> 
<223> Amino acid sequence

<400> 7
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser 
            20                  25  

<210> 8
<211> 10
<212> PRT
<213> Artificial Sequence


<220> 
<223> Amino acid sequence

<400> 8
Gly Phe Ala Phe Ser Ala Ala Tyr Met Ser 
1               5                   10  

<210> 9
<211> 14
<212> PRT
<213> Artificial Sequence


<220> 
<223> Amino acid sequence

<400> 9
Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser 
1               5                   10                  

<210> 10
<211> 10
<212> PRT
<213> Artificial Sequence


<220> 
<223> Amino acid sequence

<400> 10
Ser Ile Ser Asp Asp Gly Ser Lys Thr Tyr 
1               5                   10  

<210> 11
<211> 39
<212> PRT
<213> Artificial Sequence


<220> 
<223> Amino acid sequence

<400> 11
Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser 
1               5                   10                  15      
Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr 
            20                  25                  30          
Ala Leu Tyr Tyr Cys Asn Thr 
        35                  

<210> 12
<211> 12
<212> PRT
<213> Artificial Sequence


<220> 
<223> Amino acid sequence

<400> 12
Gly Tyr Gly Ala Thr Thr Thr Arg Pro Gly Arg Tyr 
1               5                   10          

<210> 13
<211> 11
<212> PRT
<213> Artificial Sequence


<220> 
<223> Amino acid sequence

<400> 13
Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10      

<210> 14
<211> 10
<212> PRT
<213> Artificial Sequence


<220> 
<223> Amino acid sequence

<400> 14
Gly Arg Thr Val Ser Ser Tyr Ala Met Gly 
1               5                   10  

<210> 15
<211> 14
<212> PRT
<213> Artificial Sequence


<220> 
<223> Amino acid sequence

<400> 15
Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val Ala 
1               5                   10                  

<210> 16
<211> 10
<212> PRT
<213> Artificial Sequence


<220> 
<223> Amino acid sequence

<400> 16
Gly Ile Ser Arg Ser Ala Glu Arg Thr Tyr 
1               5                   10  

<210> 17
<211> 39
<212> PRT
<213> Artificial Sequence


<220> 
<223> Amino acid sequence

<400> 17
Tyr Val Asp Ser Leu Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser 
1               5                   10                  15      
Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr 
            20                  25                  30          
Ala Leu Tyr Tyr Cys Ala Ala 
        35                  

<210> 18
<211> 15
<212> PRT
<213> Artificial Sequence


<220> 
<223> Amino acid sequence

<400> 18
Asp Leu Asp Pro Asn Arg Ile Phe Ser Arg Glu Glu Tyr Ala Tyr 
1               5                   10                  15  

<210> 19
<211> 10
<212> PRT
<213> Artificial Sequence


<220> 
<223> Amino acid sequence

<400> 19
Gly Ser Thr Phe Ile Ile Asn Val Val Arg 
1               5                   10  

<210> 20
<211> 14
<212> PRT
<213> Artificial Sequence


<220> 
<223> Amino acid sequence

<400> 20
Trp Tyr Arg Arg Ala Pro Gly Lys Gln Arg Glu Leu Val Ala 
1               5                   10                  

<210> 21
<211> 9
<212> PRT
<213> Artificial Sequence


<220> 
<223> Amino acid sequence

<400> 21
Thr Ile Ser Ser Gly Gly Asn Ala Asn 
1               5                   

<210> 22
<211> 39
<212> PRT
<213> Artificial Sequence


<220> 
<223> Amino acid sequence

<400> 22
Tyr Val Asp Ser Val Arg Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser 
1               5                   10                  15      
Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr 
            20                  25                  30          
Ala Leu Tyr Tyr Cys Asn Val 
        35                  

<210> 23
<211> 13
<212> PRT
<213> Artificial Sequence


<220> 
<223> Amino acid sequence

<400> 23
Pro Thr Thr His Tyr Gly Gly Val Tyr Tyr Gly Pro Tyr 
1               5                   10              

<210> 24
<400> 24
000

<210> 25
<211> 5
<212> PRT
<213> Artificial Sequence


<220> 
<223> Amino acid sequence

<400> 25
Gly Gly Gly Gly Ser 
1               5   

<210> 26
<211> 7
<212> PRT
<213> Artificial Sequence


<220> 
<223> Amino acid sequence

<400> 26
Ser Gly Gly Ser Gly Gly Ser 
1               5           

<210> 27
<211> 8
<212> PRT
<213> Artificial Sequence


<220> 
<223> Amino acid sequence

<400> 27
Gly Gly Gly Gly Gly Gly Gly Ser 
1               5               

<210> 28
<211> 9
<212> PRT
<213> Artificial Sequence


<220> 
<223> Amino acid sequence

<400> 28
Gly Gly Gly Gly Ser Gly Gly Gly Ser 
1               5                   

<210> 29
<211> 10
<212> PRT
<213> Artificial Sequence


<220> 
<223> Amino acid sequence

<400> 29
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10  

<210> 30
<211> 15
<212> PRT
<213> Artificial Sequence


<220> 
<223> Amino acid sequence

<400> 30
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  

<210> 31
<211> 18
<212> PRT
<213> Artificial Sequence


<220> 
<223> Amino acid sequence

<400> 31
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Gly Gly 
1               5                   10                  15      
Gly Ser 
        

<210> 32
<211> 20
<212> PRT
<213> Artificial Sequence


<220> 
<223> Amino acid sequence

<400> 32
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      
Gly Gly Gly Ser 
            20  

<210> 33
<211> 25
<212> PRT
<213> Artificial Sequence


<220> 
<223> Amino acid sequence

<400> 33
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      
Gly Gly Gly Ser Gly Gly Gly Gly Ser 
            20                  25  

<210> 34
<211> 30
<212> PRT
<213> Artificial Sequence


<220> 
<223> Amino acid sequence

<400> 34
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      
Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
            20                  25                  30  

<210> 35
<211> 35
<212> PRT
<213> Artificial Sequence


<220> 
<223> Amino acid sequence

<400> 35
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      
Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
            20                  25                  30          
Gly Gly Ser 
        35  

<210> 36
<211> 40
<212> PRT
<213> Artificial Sequence


<220> 
<223> Amino acid sequence

<400> 36
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      
Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
            20                  25                  30          
Gly Gly Ser Gly Gly Gly Gly Ser 
        35                  40  

<210> 37
<211> 15
<212> PRT
<213> Artificial Sequence


<220> 
<223> Amino acid sequence

<400> 37
Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
1               5                   10                  15  

<210> 38
<211> 24
<212> PRT
<213> Artificial Sequence


<220> 
<223> Amino acid sequence

<400> 38
Gly Gly Gly Gly Ser Gly Gly Gly Ser Glu Pro Lys Ser Cys Asp Lys 
1               5                   10                  15      
Thr His Thr Cys Pro Pro Cys Pro 
            20                  

<210> 39
<211> 12
<212> PRT
<213> Artificial Sequence


<220> 
<223> Amino acid sequence

<400> 39
Glu Pro Lys Thr Pro Lys Pro Gln Pro Ala Ala Ala 
1               5                   10          

<210> 40
<211> 62
<212> PRT
<213> Artificial Sequence


<220> 
<223> Amino acid sequence

<400> 40
Glu Leu Lys Thr Pro Leu Gly Asp Thr Thr His Thr Cys Pro Arg Cys 
1               5                   10                  15      
Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg Cys Pro 
            20                  25                  30          
Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg Cys Pro Glu 
        35                  40                  45              
Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg Cys Pro 
    50                  55                  60          

<210> 41
<211> 271
<212> PRT
<213> Artificial Sequence


<220> 
<223> Amino acid sequence

<400> 41
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Thr Phe Ile Ile Asn 
            20                  25                  30          
Val Val Arg Trp Tyr Arg Arg Thr Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              
Ala Thr Ile Ser Ser Gly Gly Asn Ala Asn Tyr Val Asp Ser Val Arg 
    50                  55                  60                  
Gly Arg Phe Ser Ile Ser Arg Asp Gly Ala Lys Asn Ala Val Asp Leu 
65                  70                  75                  80  
Gln Met Asn Gly Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Asn 
                85                  90                  95      
Val Pro Thr Thr His Tyr Gly Gly Val Tyr Tyr Gly Pro Tyr Trp Gly 
            100                 105                 110         
Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             
Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    130                 135                 140                 
Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu 
145                 150                 155                 160 
Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Asn Ser Leu Arg Leu 
                165                 170                 175     
Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Ala Val Met Ser Trp 
            180                 185                 190         
Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Ser Ile Ser 
        195                 200                 205             
Gly Ser Gly Ser Asp Thr Leu Tyr Ala Asp Ser Val Lys Gly Arg Phe 
    210                 215                 220                 
Thr Ile Ser Arg Asp Asn Ala Lys Thr Thr Leu Tyr Leu Gln Met Asn 
225                 230                 235                 240 
Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys Thr Ile Gly Gly 
                245                 250                 255     
Ser Leu Ser Arg Ser Ser Gln Gly Thr Leu Val Thr Val Ser Ser 
            260                 265                 270     

<210> 42
<211> 427
<212> PRT
<213> Artificial Sequence


<220> 
<223> Amino acid sequence

<400> 42
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Asn 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Ala 
            20                  25                  30          
Val Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ser Ser Ile Ser Gly Ser Gly Ser Asp Thr Leu Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Thr Thr Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Thr Ile Gly Gly Ser Leu Ser Arg Ser Ser Gln Gly Thr Leu Val Thr 
            100                 105                 110         
Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             
Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 
Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly 
145                 150                 155                 160 
Leu Val Gln Ala Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
                165                 170                 175     
Ser Thr Phe Ile Ile Asn Val Val Arg Trp Tyr Arg Arg Thr Pro Gly 
            180                 185                 190         
Lys Gln Arg Glu Leu Val Ala Thr Ile Ser Ser Gly Gly Asn Ala Asn 
        195                 200                 205             
Tyr Val Asp Ser Val Arg Gly Arg Phe Ser Ile Ser Arg Asp Gly Ala 
    210                 215                 220                 
Lys Asn Ala Val Asp Leu Gln Met Asn Gly Leu Lys Pro Glu Asp Thr 
225                 230                 235                 240 
Ala Val Tyr Tyr Cys Asn Val Pro Thr Thr His Tyr Gly Gly Val Tyr 
                245                 250                 255     
Tyr Gly Pro Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly 
            260                 265                 270         
Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
        275                 280                 285             
Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    290                 295                 300                 
Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala 
305                 310                 315                 320 
Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Thr Phe Ile 
                325                 330                 335     
Ile Asn Val Val Arg Trp Tyr Arg Arg Thr Pro Gly Lys Gln Arg Glu 
            340                 345                 350         
Leu Val Ala Thr Ile Ser Ser Gly Gly Asn Ala Asn Tyr Val Asp Ser 
        355                 360                 365             
Val Arg Gly Arg Phe Ser Ile Ser Arg Asp Gly Ala Lys Asn Ala Val 
    370                 375                 380                 
Asp Leu Gln Met Asn Gly Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr 
385                 390                 395                 400 
Cys Asn Val Pro Thr Thr His Tyr Gly Gly Val Tyr Tyr Gly Pro Tyr 
                405                 410                 415     
Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
            420                 425         

<210> 43
<211> 265
<212> PRT
<213> Artificial Sequence


<220> 
<223> Amino acid sequence

<400> 43
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Asn 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Ala 
            20                  25                  30          
Val Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ser Ser Ile Ser Gly Ser Gly Ser Asp Thr Leu Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Thr Thr Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Thr Ile Gly Gly Ser Leu Ser Arg Ser Ser Gln Gly Thr Leu Val Thr 
            100                 105                 110         
Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             
Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 
Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly 
145                 150                 155                 160 
Leu Val Gln Pro Gly Asn Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
                165                 170                 175     
Phe Thr Phe Ser Ser Ala Val Met Ser Trp Val Arg Gln Ala Pro Gly 
            180                 185                 190         
Lys Gly Leu Glu Trp Val Ser Ser Ile Ser Gly Ser Gly Ser Asp Thr 
        195                 200                 205             
Leu Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
    210                 215                 220                 
Ala Lys Thr Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu Asp 
225                 230                 235                 240 
Thr Ala Val Tyr Tyr Cys Thr Ile Gly Gly Ser Leu Ser Arg Ser Ser 
                245                 250                 255     
Gln Gly Thr Leu Val Thr Val Ser Ser 
            260                 265 

<210> 44
<211> 115
<212> PRT
<213> Artificial Sequence


<220> 
<223> Amino acid sequence

<400> 44
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Asn 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe 
            20                  25                  30          
Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ser Ser Ile Ser Gly Ser Gly Ser Asp Thr Leu Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Thr Thr Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Thr Ile Gly Gly Ser Leu Ser Arg Ser Ser Gln Gly Thr Leu Val Thr 
            100                 105                 110         
Val Ser Ser 
        115 

<210> 45
<211> 115
<212> PRT
<213> Artificial Sequence


<220> 
<223> Amino acid sequence

<400> 45
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Ser Phe 
            20                  25                  30          
Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Pro Glu Trp Val 
        35                  40                  45              
Ser Ser Ile Ser Gly Ser Gly Ser Asp Thr Leu Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Thr Ile Gly Gly Ser Leu Ser Arg Ser Ser Gln Gly Thr Leu Val Thr 
            100                 105                 110         
Val Ser Ser 
        115 

<210> 46
<211> 116
<212> PRT
<213> Artificial Sequence


<220> 
<223> Amino acid sequence

<400> 46
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Asn 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe 
            20                  25                  30          
Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ser Ser Ile Ser Gly Ser Gly Ser Asp Thr Leu Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Thr Thr Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Thr Tyr Tyr Cys 
                85                  90                  95      
Thr Ile Gly Gly Ser Leu Ser Arg Ser Ser Gln Gly Thr Leu Val Thr 
            100                 105                 110         
Val Ser Ser Ala 
        115     

<210> 47
<211> 116
<212> PRT
<213> Artificial Sequence


<220> 
<223> Amino acid sequence

<400> 47
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Ser Phe 
            20                  25                  30          
Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Pro Glu Trp Val 
        35                  40                  45              
Ser Ser Ile Ser Gly Ser Gly Ser Asp Thr Leu Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Thr Tyr Tyr Cys 
                85                  90                  95      
Thr Ile Gly Gly Ser Leu Ser Arg Ser Ser Gln Gly Thr Leu Val Thr 
            100                 105                 110         
Val Ser Ser Ala 
        115     

<210> 48
<211> 115
<212> PRT
<213> Artificial Sequence


<220> 
<223> Amino acid sequence

<400> 48
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Asn 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe 
            20                  25                  30          
Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ser Ser Ile Ser Gly Ser Gly Ser Asp Thr Leu Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Thr Thr Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Thr Ile Gly Gly Ser Leu Ser Arg Ser Ser Gln Gly Thr Leu Val Thr 
            100                 105                 110         
Val Ser Ser 
        115 

<210> 49
<211> 116
<212> PRT
<213> Artificial Sequence


<220> 
<223> Amino acid sequence

<400> 49
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Asn 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe 
            20                  25                  30          
Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ser Ser Ile Ser Gly Ser Gly Ser Asp Thr Leu Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Thr Thr Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Thr Ile Gly Gly Ser Leu Ser Arg Ser Ser Gln Gly Thr Leu Val Lys 
            100                 105                 110         
Val Ser Ser Ala 
        115     

<210> 50
<211> 115
<212> PRT
<213> Artificial Sequence


<220> 
<223> Amino acid sequence

<400> 50
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Asn 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe 
            20                  25                  30          
Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ser Ser Ile Ser Gly Ser Gly Ser Asp Thr Leu Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Thr Thr Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      
Thr Ile Gly Gly Ser Leu Ser Arg Ser Ser Gln Gly Thr Leu Val Thr 
            100                 105                 110         
Val Ser Ser 
        115 

<210> 51
<211> 116
<212> PRT
<213> Artificial Sequence


<220> 
<223> Amino acid sequence

<400> 51
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Asn 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe 
            20                  25                  30          
Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ser Ser Ile Ser Gly Ser Gly Ser Asp Thr Leu Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Thr Thr Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      
Thr Ile Gly Gly Ser Leu Ser Arg Ser Ser Gln Gly Thr Leu Val Thr 
            100                 105                 110         
Val Ser Ser Ala 
        115     

<210> 52
<211> 117
<212> PRT
<213> Artificial Sequence


<220> 
<223> Amino acid sequence

<400> 52
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Asn 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe 
            20                  25                  30          
Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ser Ser Ile Ser Gly Ser Gly Ser Asp Thr Leu Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Thr Thr Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      
Thr Ile Gly Gly Ser Leu Ser Arg Ser Ser Gln Gly Thr Leu Val Thr 
            100                 105                 110         
Val Ser Ser Ala Ala 
        115         

<210> 53
<211> 118
<212> PRT
<213> Artificial Sequence


<220> 
<223> Amino acid sequence

<400> 53
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Asn 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe 
            20                  25                  30          
Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ser Ser Ile Ser Gly Ser Gly Ser Asp Thr Leu Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Thr Thr Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      
Thr Ile Gly Gly Ser Leu Ser Arg Ser Ser Gln Gly Thr Leu Val Thr 
            100                 105                 110         
Val Ser Ser Ala Ala Ala 
        115             

<210> 54
<211> 116
<212> PRT
<213> Artificial Sequence


<220> 
<223> Amino acid sequence

<400> 54
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Asn 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe 
            20                  25                  30          
Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ser Ser Ile Ser Gly Ser Gly Ser Asp Thr Leu Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Thr Thr Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      
Thr Ile Gly Gly Ser Leu Ser Arg Ser Ser Gln Gly Thr Leu Val Thr 
            100                 105                 110         
Val Ser Ser Gly 
        115     

<210> 55
<211> 117
<212> PRT
<213> Artificial Sequence


<220> 
<223> Amino acid sequence

<400> 55
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Asn 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe 
            20                  25                  30          
Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ser Ser Ile Ser Gly Ser Gly Ser Asp Thr Leu Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Thr Thr Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      
Thr Ile Gly Gly Ser Leu Ser Arg Ser Ser Gln Gly Thr Leu Val Thr 
            100                 105                 110         
Val Ser Ser Gly Gly 
        115         

<210> 56
<211> 118
<212> PRT
<213> Artificial Sequence


<220> 
<223> Amino acid sequence

<400> 56
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Asn 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe 
            20                  25                  30          
Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ser Ser Ile Ser Gly Ser Gly Ser Asp Thr Leu Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Thr Thr Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      
Thr Ile Gly Gly Ser Leu Ser Arg Ser Ser Gln Gly Thr Leu Val Thr 
            100                 105                 110         
Val Ser Ser Gly Gly Gly 
        115             

<210> 57
<211> 115
<212> PRT
<213> Artificial Sequence


<220> 
<223> Amino acid sequence

<400> 57
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Ser Phe 
            20                  25                  30          
Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Pro Glu Trp Val 
        35                  40                  45              
Ser Ser Ile Ser Gly Ser Gly Ser Asp Thr Leu Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      
Thr Ile Gly Gly Ser Leu Ser Arg Ser Ser Gln Gly Thr Leu Val Thr 
            100                 105                 110         
Val Ser Ser 
        115 

<210> 58
<211> 116
<212> PRT
<213> Artificial Sequence


<220> 
<223> Amino acid sequence

<400> 58
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Ser Phe 
            20                  25                  30          
Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Pro Glu Trp Val 
        35                  40                  45              
Ser Ser Ile Ser Gly Ser Gly Ser Asp Thr Leu Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      
Thr Ile Gly Gly Ser Leu Ser Arg Ser Ser Gln Gly Thr Leu Val Thr 
            100                 105                 110         
Val Ser Ser Ala 
        115     

<210> 59
<211> 5
<212> PRT
<213> Artificial Sequence


<220> 
<223> Amino acid sequence

<400> 59
Ser Phe Gly Met Ser 
1               5   

<210> 60
<211> 17
<212> PRT
<213> Artificial Sequence


<220> 
<223> Amino acid sequence

<400> 60
Ser Ile Ser Gly Ser Gly Ser Asp Thr Leu Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      
Gly 
    

<210> 61
<211> 6
<212> PRT
<213> Artificial Sequence


<220> 
<223> Amino acid sequence

<400> 61
Gly Gly Ser Leu Ser Arg 
1               5       

<210> 62
<211> 515
<212> PRT
<213> Artificial Sequence


<220> 
<223> Amino acid sequence

<400> 62
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ala Phe Ser Ala Ala 
            20                  25                  30          
Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ser Ser Ile Ser Asp Asp Gly Ser Lys Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      
Asn Thr Gly Tyr Gly Ala Thr Thr Thr Arg Pro Gly Arg Tyr Trp Gly 
            100                 105                 110         
Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             
Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro 
    130                 135                 140                 
Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Val Ser 
145                 150                 155                 160 
Ser Tyr Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu 
                165                 170                 175     
Phe Val Ala Gly Ile Ser Arg Ser Ala Glu Arg Thr Tyr Tyr Val Asp 
            180                 185                 190         
Ser Leu Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr 
        195                 200                 205             
Val Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr 
    210                 215                 220                 
Tyr Cys Ala Ala Asp Leu Asp Pro Asn Arg Ile Phe Ser Arg Glu Glu 
225                 230                 235                 240 
Tyr Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly 
                245                 250                 255     
Gly Gly Ser Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly 
            260                 265                 270         
Gly Val Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser 
        275                 280                 285             
Gly Ser Thr Phe Ile Ile Asn Val Val Arg Trp Tyr Arg Arg Ala Pro 
    290                 295                 300                 
Gly Lys Gln Arg Glu Leu Val Ala Thr Ile Ser Ser Gly Gly Asn Ala 
305                 310                 315                 320 
Asn Tyr Val Asp Ser Val Arg Gly Arg Phe Thr Ile Ser Arg Asp Asn 
                325                 330                 335     
Ser Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu Asp 
            340                 345                 350         
Thr Ala Leu Tyr Tyr Cys Asn Val Pro Thr Thr His Tyr Gly Gly Val 
        355                 360                 365             
Tyr Tyr Gly Pro Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
    370                 375                 380                 
Gly Gly Gly Gly Ser Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser 
385                 390                 395                 400 
Gly Gly Gly Val Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala 
                405                 410                 415     
Ala Ser Gly Ser Thr Phe Ile Ile Asn Val Val Arg Trp Tyr Arg Arg 
            420                 425                 430         
Ala Pro Gly Lys Gln Arg Glu Leu Val Ala Thr Ile Ser Ser Gly Gly 
        435                 440                 445             
Asn Ala Asn Tyr Val Asp Ser Val Arg Gly Arg Phe Thr Ile Ser Arg 
    450                 455                 460                 
Asp Asn Ser Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Arg Pro 
465                 470                 475                 480 
Glu Asp Thr Ala Leu Tyr Tyr Cys Asn Val Pro Thr Thr His Tyr Gly 
                485                 490                 495     
Gly Val Tyr Tyr Gly Pro Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
            500                 505                 510         
Ser Ser Ala 
        515 

<210> 63
<211> 382
<212> PRT
<213> Artificial Sequence


<220> 
<223> Amino acid sequence

<400> 63
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ala Phe Ser Ala Ala 
            20                  25                  30          
Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ser Ser Ile Ser Asp Asp Gly Ser Lys Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      
Asn Thr Gly Tyr Gly Ala Thr Thr Thr Arg Pro Gly Arg Tyr Trp Gly 
            100                 105                 110         
Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             
Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro 
    130                 135                 140                 
Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Thr Phe Ile 
145                 150                 155                 160 
Ile Asn Val Val Arg Trp Tyr Arg Arg Ala Pro Gly Lys Gln Arg Glu 
                165                 170                 175     
Leu Val Ala Thr Ile Ser Ser Gly Gly Asn Ala Asn Tyr Val Asp Ser 
            180                 185                 190         
Val Arg Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val 
        195                 200                 205             
Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr 
    210                 215                 220                 
Cys Asn Val Pro Thr Thr His Tyr Gly Gly Val Tyr Tyr Gly Pro Tyr 
225                 230                 235                 240 
Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
                245                 250                 255     
Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val 
            260                 265                 270         
Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Thr 
        275                 280                 285             
Phe Ile Ile Asn Val Val Arg Trp Tyr Arg Arg Ala Pro Gly Lys Gln 
    290                 295                 300                 
Arg Glu Leu Val Ala Thr Ile Ser Ser Gly Gly Asn Ala Asn Tyr Val 
305                 310                 315                 320 
Asp Ser Val Arg Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn 
                325                 330                 335     
Thr Val Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu 
            340                 345                 350         
Tyr Tyr Cys Asn Val Pro Thr Thr His Tyr Gly Gly Val Tyr Tyr Gly 
        355                 360                 365             
Pro Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala 
    370                 375                 380         

<210> 64
<211> 385
<212> PRT
<213> Artificial Sequence


<220> 
<223> Amino acid sequence

<400> 64
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Val Ser Ser Tyr 
            20                  25                  30          
Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              
Ala Gly Ile Ser Arg Ser Ala Glu Arg Thr Tyr Tyr Val Asp Ser Leu 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      
Ala Ala Asp Leu Asp Pro Asn Arg Ile Phe Ser Arg Glu Glu Tyr Ala 
            100                 105                 110         
Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly 
        115                 120                 125             
Ser Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val 
    130                 135                 140                 
Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser 
145                 150                 155                 160 
Thr Phe Ile Ile Asn Val Val Arg Trp Tyr Arg Arg Ala Pro Gly Lys 
                165                 170                 175     
Gln Arg Glu Leu Val Ala Thr Ile Ser Ser Gly Gly Asn Ala Asn Tyr 
            180                 185                 190         
Val Asp Ser Val Arg Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys 
        195                 200                 205             
Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala 
    210                 215                 220                 
Leu Tyr Tyr Cys Asn Val Pro Thr Thr His Tyr Gly Gly Val Tyr Tyr 
225                 230                 235                 240 
Gly Pro Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly 
                245                 250                 255     
Gly Gly Ser Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly 
            260                 265                 270         
Gly Val Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser 
        275                 280                 285             
Gly Ser Thr Phe Ile Ile Asn Val Val Arg Trp Tyr Arg Arg Ala Pro 
    290                 295                 300                 
Gly Lys Gln Arg Glu Leu Val Ala Thr Ile Ser Ser Gly Gly Asn Ala 
305                 310                 315                 320 
Asn Tyr Val Asp Ser Val Arg Gly Arg Phe Thr Ile Ser Arg Asp Asn 
                325                 330                 335     
Ser Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu Asp 
            340                 345                 350         
Thr Ala Leu Tyr Tyr Cys Asn Val Pro Thr Thr His Tyr Gly Gly Val 
        355                 360                 365             
Tyr Tyr Gly Pro Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
    370                 375                 380                 
Ala 
385 

<210> 65
<211> 275
<212> PRT
<213> Artificial Sequence


<220> 
<223> Amino acid sequence

<400> 65
Asp Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Val Ser Ser Tyr 
            20                  25                  30          
Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              
Ala Gly Ile Ser Arg Ser Ala Glu Arg Thr Tyr Tyr Val Asp Ser Leu 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      
Ala Ala Asp Leu Asp Pro Asn Arg Ile Phe Ser Arg Glu Glu Tyr Ala 
            100                 105                 110         
Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly 
        115                 120                 125             
Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu 
145                 150                 155                 160 
Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Asn Ser 
                165                 170                 175     
Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe Gly 
            180                 185                 190         
Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser 
        195                 200                 205             
Ser Ile Ser Gly Ser Gly Ser Asp Thr Leu Tyr Ala Asp Ser Val Lys 
    210                 215                 220                 
Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Thr Thr Leu Tyr Leu 
225                 230                 235                 240 
Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys Thr 
                245                 250                 255     
Ile Gly Gly Ser Leu Ser Arg Ser Ser Gln Gly Thr Leu Val Thr Val 
            260                 265                 270         
Ser Ser Ala 
        275 

<210> 66
<211> 471
<212> PRT
<213> Homo sapiens


<220> 
<223> Amino acid sequence

<400> 66
Met His Pro Gly Val Leu Ala Ala Phe Leu Phe Leu Ser Trp Thr His 
1               5                   10                  15      
Cys Arg Ala Leu Pro Leu Pro Ser Gly Gly Asp Glu Asp Asp Leu Ser 
            20                  25                  30          
Glu Glu Asp Leu Gln Phe Ala Glu Arg Tyr Leu Arg Ser Tyr Tyr His 
        35                  40                  45              
Pro Thr Asn Leu Ala Gly Ile Leu Lys Glu Asn Ala Ala Ser Ser Met 
    50                  55                  60                  
Thr Glu Arg Leu Arg Glu Met Gln Ser Phe Phe Gly Leu Glu Val Thr 
65                  70                  75                  80  
Gly Lys Leu Asp Asp Asn Thr Leu Asp Val Met Lys Lys Pro Arg Cys 
                85                  90                  95      
Gly Val Pro Asp Val Gly Glu Tyr Asn Val Phe Pro Arg Thr Leu Lys 
            100                 105                 110         
Trp Ser Lys Met Asn Leu Thr Tyr Arg Ile Val Asn Tyr Thr Pro Asp 
        115                 120                 125             
Met Thr His Ser Glu Val Glu Lys Ala Phe Lys Lys Ala Phe Lys Val 
    130                 135                 140                 
Trp Ser Asp Val Thr Pro Leu Asn Phe Thr Arg Leu His Asp Gly Ile 
145                 150                 155                 160 
Ala Asp Ile Met Ile Ser Phe Gly Ile Lys Glu His Gly Asp Phe Tyr 
                165                 170                 175     
Pro Phe Asp Gly Pro Ser Gly Leu Leu Ala His Ala Phe Pro Pro Gly 
            180                 185                 190         
Pro Asn Tyr Gly Gly Asp Ala His Phe Asp Asp Asp Glu Thr Trp Thr 
        195                 200                 205             
Ser Ser Ser Lys Gly Tyr Asn Leu Phe Leu Val Ala Ala His Glu Phe 
    210                 215                 220                 
Gly His Ser Leu Gly Leu Asp His Ser Lys Asp Pro Gly Ala Leu Met 
225                 230                 235                 240 
Phe Pro Ile Tyr Thr Tyr Thr Gly Lys Ser His Phe Met Leu Pro Asp 
                245                 250                 255     
Asp Asp Val Gln Gly Ile Gln Ser Leu Tyr Gly Pro Gly Asp Glu Asp 
            260                 265                 270         
Pro Asn Pro Lys His Pro Lys Thr Pro Asp Lys Cys Asp Pro Ser Leu 
        275                 280                 285             
Ser Leu Asp Ala Ile Thr Ser Leu Arg Gly Glu Thr Met Ile Phe Lys 
    290                 295                 300                 
Asp Arg Phe Phe Trp Arg Leu His Pro Gln Gln Val Asp Ala Glu Leu 
305                 310                 315                 320 
Phe Leu Thr Lys Ser Phe Trp Pro Glu Leu Pro Asn Arg Ile Asp Ala 
                325                 330                 335     
Ala Tyr Glu His Pro Ser His Asp Leu Ile Phe Ile Phe Arg Gly Arg 
            340                 345                 350         
Lys Phe Trp Ala Leu Asn Gly Tyr Asp Ile Leu Glu Gly Tyr Pro Lys 
        355                 360                 365             
Lys Ile Ser Glu Leu Gly Leu Pro Lys Glu Val Lys Lys Ile Ser Ala 
    370                 375                 380                 
Ala Val His Phe Glu Asp Thr Gly Lys Thr Leu Leu Phe Ser Gly Asn 
385                 390                 395                 400 
Gln Val Trp Arg Tyr Asp Asp Thr Asn His Ile Met Asp Lys Asp Tyr 
                405                 410                 415     
Pro Arg Leu Ile Glu Glu Asp Phe Pro Gly Ile Gly Asp Lys Val Asp 
            420                 425                 430         
Ala Val Tyr Glu Lys Asn Gly Tyr Ile Tyr Phe Phe Asn Gly Pro Ile 
        435                 440                 445             
Gln Phe Glu Tyr Ser Ile Trp Ser Asn Arg Ile Val Arg Val Met Pro 
    450                 455                 460                 
Ala Asn Ser Ile Leu Trp Cys 
465                 470     

<210> 67
<211> 930
<212> PRT
<213> Homo sapiens


<220> 
<223> Amino acid sequence

<400> 67
Met Leu Leu Gly Trp Ala Ser Leu Leu Leu Cys Ala Phe Arg Leu Pro 
1               5                   10                  15      
Leu Ala Ala Val Gly Pro Ala Ala Thr Pro Ala Gln Asp Lys Ala Gly 
            20                  25                  30          
Gln Pro Pro Thr Ala Ala Ala Ala Ala Gln Pro Arg Arg Arg Gln Gly 
        35                  40                  45              
Glu Glu Val Gln Glu Arg Ala Glu Pro Pro Gly His Pro His Pro Leu 
    50                  55                  60                  
Ala Gln Arg Arg Arg Ser Lys Gly Leu Val Gln Asn Ile Asp Gln Leu 
65                  70                  75                  80  
Tyr Ser Gly Gly Gly Lys Val Gly Tyr Leu Val Tyr Ala Gly Gly Arg 
                85                  90                  95      
Arg Phe Leu Leu Asp Leu Glu Arg Asp Gly Ser Val Gly Ile Ala Gly 
            100                 105                 110         
Phe Val Pro Ala Gly Gly Gly Thr Ser Ala Pro Trp Arg His Arg Ser 
        115                 120                 125             
His Cys Phe Tyr Arg Gly Thr Val Asp Gly Ser Pro Arg Ser Leu Ala 
    130                 135                 140                 
Val Phe Asp Leu Cys Gly Gly Leu Asp Gly Phe Phe Ala Val Lys His 
145                 150                 155                 160 
Ala Arg Tyr Thr Leu Lys Pro Leu Leu Arg Gly Pro Trp Ala Glu Glu 
                165                 170                 175     
Glu Lys Gly Arg Val Tyr Gly Asp Gly Ser Ala Arg Ile Leu His Val 
            180                 185                 190         
Tyr Thr Arg Glu Gly Phe Ser Phe Glu Ala Leu Pro Pro Arg Ala Ser 
        195                 200                 205             
Cys Glu Thr Pro Ala Ser Thr Pro Glu Ala His Glu His Ala Pro Ala 
    210                 215                 220                 
His Ser Asn Pro Ser Gly Arg Ala Ala Leu Ala Ser Gln Leu Leu Asp 
225                 230                 235                 240 
Gln Ser Ala Leu Ser Pro Ala Gly Gly Ser Gly Pro Gln Thr Trp Trp 
                245                 250                 255     
Arg Arg Arg Arg Arg Ser Ile Ser Arg Ala Arg Gln Val Glu Leu Leu 
            260                 265                 270         
Leu Val Ala Asp Ala Ser Met Ala Arg Leu Tyr Gly Arg Gly Leu Gln 
        275                 280                 285             
His Tyr Leu Leu Thr Leu Ala Ser Ile Ala Asn Arg Leu Tyr Ser His 
    290                 295                 300                 
Ala Ser Ile Glu Asn His Ile Arg Leu Ala Val Val Lys Val Val Val 
305                 310                 315                 320 
Leu Gly Asp Lys Asp Lys Ser Leu Glu Val Ser Lys Asn Ala Ala Thr 
                325                 330                 335     
Thr Leu Lys Asn Phe Cys Lys Trp Gln His Gln His Asn Gln Leu Gly 
            340                 345                 350         
Asp Asp His Glu Glu His Tyr Asp Ala Ala Ile Leu Phe Thr Arg Glu 
        355                 360                 365             
Asp Leu Cys Gly His His Ser Cys Asp Thr Leu Gly Met Ala Asp Val 
    370                 375                 380                 
Gly Thr Ile Cys Ser Pro Glu Arg Ser Cys Ala Val Ile Glu Asp Asp 
385                 390                 395                 400 
Gly Leu His Ala Ala Phe Thr Val Ala His Glu Ile Gly His Leu Leu 
                405                 410                 415     
Gly Leu Ser His Asp Asp Ser Lys Phe Cys Glu Glu Thr Phe Gly Ser 
            420                 425                 430         
Thr Glu Asp Lys Arg Leu Met Ser Ser Ile Leu Thr Ser Ile Asp Ala 
        435                 440                 445             
Ser Lys Pro Trp Ser Lys Cys Thr Ser Ala Thr Ile Thr Glu Phe Leu 
    450                 455                 460                 
Asp Asp Gly His Gly Asn Cys Leu Leu Asp Leu Pro Arg Lys Gln Ile 
465                 470                 475                 480 
Leu Gly Pro Glu Glu Leu Pro Gly Gln Thr Tyr Asp Ala Thr Gln Gln 
                485                 490                 495     
Cys Asn Leu Thr Phe Gly Pro Glu Tyr Ser Val Cys Pro Gly Met Asp 
            500                 505                 510         
Val Cys Ala Arg Leu Trp Cys Ala Val Val Arg Gln Gly Gln Met Val 
        515                 520                 525             
Cys Leu Thr Lys Lys Leu Pro Ala Val Glu Gly Thr Pro Cys Gly Lys 
    530                 535                 540                 
Gly Arg Ile Cys Leu Gln Gly Lys Cys Val Asp Lys Thr Lys Lys Lys 
545                 550                 555                 560 
Tyr Tyr Ser Thr Ser Ser His Gly Asn Trp Gly Ser Trp Gly Ser Trp 
                565                 570                 575     
Gly Gln Cys Ser Arg Ser Cys Gly Gly Gly Val Gln Phe Ala Tyr Arg 
            580                 585                 590         
His Cys Asn Asn Pro Ala Pro Arg Asn Asn Gly Arg Tyr Cys Thr Gly 
        595                 600                 605             
Lys Arg Ala Ile Tyr Arg Ser Cys Ser Leu Met Pro Cys Pro Pro Asn 
    610                 615                 620                 
Gly Lys Ser Phe Arg His Glu Gln Cys Glu Ala Lys Asn Gly Tyr Gln 
625                 630                 635                 640 
Ser Asp Ala Lys Gly Val Lys Thr Phe Val Glu Trp Val Pro Lys Tyr 
                645                 650                 655     
Ala Gly Val Leu Pro Ala Asp Val Cys Lys Leu Thr Cys Arg Ala Lys 
            660                 665                 670         
Gly Thr Gly Tyr Tyr Val Val Phe Ser Pro Lys Val Thr Asp Gly Thr 
        675                 680                 685             
Glu Cys Arg Leu Tyr Ser Asn Ser Val Cys Val Arg Gly Lys Cys Val 
    690                 695                 700                 
Arg Thr Gly Cys Asp Gly Ile Ile Gly Ser Lys Leu Gln Tyr Asp Lys 
705                 710                 715                 720 
Cys Gly Val Cys Gly Gly Asp Asn Ser Ser Cys Thr Lys Ile Val Gly 
                725                 730                 735     
Thr Phe Asn Lys Lys Ser Lys Gly Tyr Thr Asp Val Val Arg Ile Pro 
            740                 745                 750         
Glu Gly Ala Thr His Ile Lys Val Arg Gln Phe Lys Ala Lys Asp Gln 
        755                 760                 765             
Thr Arg Phe Thr Ala Tyr Leu Ala Leu Lys Lys Lys Asn Gly Glu Tyr 
    770                 775                 780                 
Leu Ile Asn Gly Lys Tyr Met Ile Ser Thr Ser Glu Thr Ile Ile Asp 
785                 790                 795                 800 
Ile Asn Gly Thr Val Met Asn Tyr Ser Gly Trp Ser His Arg Asp Asp 
                805                 810                 815     
Phe Leu His Gly Met Gly Tyr Ser Ala Thr Lys Glu Ile Leu Ile Val 
            820                 825                 830         
Gln Ile Leu Ala Thr Asp Pro Thr Lys Pro Leu Asp Val Arg Tyr Ser 
        835                 840                 845             
Phe Phe Val Pro Lys Lys Ser Thr Pro Lys Val Asn Ser Val Thr Ser 
    850                 855                 860                 
His Gly Ser Asn Lys Val Gly Ser His Thr Ser Gln Pro Gln Trp Val 
865                 870                 875                 880 
Thr Gly Pro Trp Leu Ala Cys Ser Arg Thr Cys Asp Thr Gly Trp His 
                885                 890                 895     
Thr Arg Thr Val Gln Cys Gln Asp Gly Asn Arg Lys Leu Ala Lys Gly 
            900                 905                 910         
Cys Pro Leu Ser Gln Arg Pro Ser Ala Phe Lys Gln Cys Leu Leu Lys 
        915                 920                 925             
Lys Cys 
    930 

<210> 68
<211> 2415
<212> PRT
<213> Artificial Sequence


<220> 
<223> Amino acid sequence

<400> 68
Met Thr Thr Leu Leu Trp Val Phe Val Thr Leu Arg Val Ile Thr Ala 
1               5                   10                  15      
Ala Val Thr Val Glu Thr Ser Asp His Asp Asn Ser Leu Ser Val Ser 
            20                  25                  30          
Ile Pro Gln Pro Ser Pro Leu Arg Val Leu Leu Gly Thr Ser Leu Thr 
        35                  40                  45              
Ile Pro Cys Tyr Phe Ile Asp Pro Met His Pro Val Thr Thr Ala Pro 
    50                  55                  60                  
Ser Thr Ala Pro Leu Ala Pro Arg Ile Lys Trp Ser Arg Val Ser Lys 
65                  70                  75                  80  
Glu Lys Glu Val Val Leu Leu Val Ala Thr Glu Gly Arg Val Arg Val 
                85                  90                  95      
Asn Ser Ala Tyr Gln Asp Lys Val Ser Leu Pro Asn Tyr Pro Ala Ile 
            100                 105                 110         
Pro Ser Asp Ala Thr Leu Glu Val Gln Ser Leu Arg Ser Asn Asp Ser 
        115                 120                 125             
Gly Val Tyr Arg Cys Glu Val Met His Gly Ile Glu Asp Ser Glu Ala 
    130                 135                 140                 
Thr Leu Glu Val Val Val Lys Gly Ile Val Phe His Tyr Arg Ala Ile 
145                 150                 155                 160 
Ser Thr Arg Tyr Thr Leu Asp Phe Asp Arg Ala Gln Arg Ala Cys Leu 
                165                 170                 175     
Gln Asn Ser Ala Ile Ile Ala Thr Pro Glu Gln Leu Gln Ala Ala Tyr 
            180                 185                 190         
Glu Asp Gly Phe His Gln Cys Asp Ala Gly Trp Leu Ala Asp Gln Thr 
        195                 200                 205             
Val Arg Tyr Pro Ile His Thr Pro Arg Glu Gly Cys Tyr Gly Asp Lys 
    210                 215                 220                 
Asp Glu Phe Pro Gly Val Arg Thr Tyr Gly Ile Arg Asp Thr Asn Glu 
225                 230                 235                 240 
Thr Tyr Asp Val Tyr Cys Phe Ala Glu Glu Met Glu Gly Glu Val Phe 
                245                 250                 255     
Tyr Ala Thr Ser Pro Glu Lys Phe Thr Phe Gln Glu Ala Ala Asn Glu 
            260                 265                 270         
Cys Arg Arg Leu Gly Ala Arg Leu Ala Thr Thr Gly His Val Tyr Leu 
        275                 280                 285             
Ala Trp Gln Ala Gly Met Asp Met Cys Ser Ala Gly Trp Leu Ala Asp 
    290                 295                 300                 
Arg Ser Val Arg Tyr Pro Ile Ser Lys Ala Arg Pro Asn Cys Gly Gly 
305                 310                 315                 320 
Asn Leu Leu Gly Val Arg Thr Val Tyr Val His Ala Asn Gln Thr Gly 
                325                 330                 335     
Tyr Pro Asp Pro Ser Ser Arg Tyr Asp Ala Ile Cys Tyr Thr Gly Glu 
            340                 345                 350         
Asp Phe Val Asp Ile Pro Glu Asn Phe Phe Gly Val Gly Gly Glu Glu 
        355                 360                 365             
Asp Ile Thr Val Gln Thr Val Thr Trp Pro Asp Met Glu Leu Pro Leu 
    370                 375                 380                 
Pro Arg Asn Ile Thr Glu Gly Glu Ala Arg Gly Ser Val Ile Leu Thr 
385                 390                 395                 400 
Val Lys Pro Ile Phe Glu Val Ser Pro Ser Pro Leu Glu Pro Glu Glu 
                405                 410                 415     
Pro Phe Thr Phe Ala Pro Glu Ile Gly Ala Thr Ala Phe Ala Glu Val 
            420                 425                 430         
Glu Asn Glu Thr Gly Glu Ala Thr Arg Pro Trp Gly Phe Pro Thr Pro 
        435                 440                 445             
Gly Leu Gly Pro Ala Thr Ala Phe Thr Ser Glu Asp Leu Val Val Gln 
    450                 455                 460                 
Val Thr Ala Val Pro Gly Gln Pro His Leu Pro Gly Gly Val Val Phe 
465                 470                 475                 480 
His Tyr Arg Pro Gly Pro Thr Arg Tyr Ser Leu Thr Phe Glu Glu Ala 
                485                 490                 495     
Gln Gln Ala Cys Pro Gly Thr Gly Ala Val Ile Ala Ser Pro Glu Gln 
            500                 505                 510         
Leu Gln Ala Ala Tyr Glu Ala Gly Tyr Glu Gln Cys Asp Ala Gly Trp 
        515                 520                 525             
Leu Arg Asp Gln Thr Val Arg Tyr Pro Ile Val Ser Pro Arg Thr Pro 
    530                 535                 540                 
Cys Val Gly Asp Lys Asp Ser Ser Pro Gly Val Arg Thr Tyr Gly Val 
545                 550                 555                 560 
Arg Pro Ser Thr Glu Thr Tyr Asp Val Tyr Cys Phe Val Asp Arg Leu 
                565                 570                 575     
Glu Gly Glu Val Phe Phe Ala Thr Arg Leu Glu Gln Phe Thr Phe Gln 
            580                 585                 590         
Glu Ala Leu Glu Phe Cys Glu Ser His Asn Ala Thr Ala Thr Thr Gly 
        595                 600                 605             
Gln Leu Tyr Ala Ala Trp Ser Arg Gly Leu Asp Lys Cys Tyr Ala Gly 
    610                 615                 620                 
Trp Leu Ala Asp Gly Ser Leu Arg Tyr Pro Ile Val Thr Pro Arg Pro 
625                 630                 635                 640 
Ala Cys Gly Gly Asp Lys Pro Gly Val Arg Thr Val Tyr Leu Tyr Pro 
                645                 650                 655     
Asn Gln Thr Gly Leu Pro Asp Pro Leu Ser Arg His His Ala Phe Cys 
            660                 665                 670         
Phe Arg Gly Ile Ser Ala Val Pro Ser Pro Gly Glu Glu Glu Gly Gly 
        675                 680                 685             
Thr Pro Thr Ser Pro Ser Gly Val Glu Glu Trp Ile Val Thr Gln Val 
    690                 695                 700                 
Val Pro Gly Val Ala Ala Val Pro Val Glu Glu Glu Thr Thr Ala Val 
705                 710                 715                 720 
Pro Ser Gly Glu Thr Thr Ala Ile Leu Glu Phe Thr Thr Glu Pro Glu 
                725                 730                 735     
Asn Gln Thr Glu Trp Glu Pro Ala Tyr Thr Pro Val Gly Thr Ser Pro 
            740                 745                 750         
Leu Pro Gly Ile Leu Pro Thr Trp Pro Pro Thr Gly Ala Glu Thr Glu 
        755                 760                 765             
Glu Ser Thr Glu Gly Pro Ser Ala Thr Glu Val Pro Ser Ala Ser Glu 
    770                 775                 780                 
Glu Pro Ser Pro Ser Glu Val Pro Phe Pro Ser Glu Glu Pro Ser Pro 
785                 790                 795                 800 
Ser Glu Glu Pro Phe Pro Ser Val Arg Pro Phe Pro Ser Val Glu Leu 
                805                 810                 815     
Phe Pro Ser Glu Glu Pro Phe Pro Ser Lys Glu Pro Ser Pro Ser Glu 
            820                 825                 830         
Glu Pro Ser Ala Ser Glu Glu Pro Tyr Thr Pro Ser Pro Pro Glu Pro 
        835                 840                 845             
Ser Trp Thr Glu Leu Pro Ser Ser Gly Glu Glu Ser Gly Ala Pro Asp 
    850                 855                 860                 
Val Ser Gly Asp Phe Thr Gly Ser Gly Asp Val Ser Gly His Leu Asp 
865                 870                 875                 880 
Phe Ser Gly Gln Leu Ser Gly Asp Arg Ala Ser Gly Leu Pro Ser Gly 
                885                 890                 895     
Asp Leu Asp Ser Ser Gly Leu Thr Ser Thr Val Gly Ser Gly Leu Thr 
            900                 905                 910         
Val Glu Ser Gly Leu Pro Ser Gly Asp Glu Glu Arg Ile Glu Trp Pro 
        915                 920                 925             
Ser Thr Pro Thr Val Gly Glu Leu Pro Ser Gly Ala Glu Ile Leu Glu 
    930                 935                 940                 
Gly Ser Ala Ser Gly Val Gly Asp Leu Ser Gly Leu Pro Ser Gly Glu 
945                 950                 955                 960 
Val Leu Glu Thr Ser Ala Ser Gly Val Gly Asp Leu Ser Gly Leu Pro 
                965                 970                 975     
Ser Gly Glu Val Leu Glu Thr Thr Ala Pro Gly Val Glu Asp Ile Ser 
            980                 985                 990         
Gly Leu Pro Ser Gly Glu Val Leu Glu Thr Thr Ala Pro Gly Val Glu 
        995                 1000                1005            
Asp Ile Ser Gly Leu Pro Ser Gly Glu Val Leu Glu Thr Thr Ala Pro 
    1010                1015                1020                
Gly Val Glu Asp Ile Ser Gly Leu Pro Ser Gly Glu Val Leu Glu Thr 
1025                1030                1035                1040
Thr Ala Pro Gly Val Glu Asp Ile Ser Gly Leu Pro Ser Gly Glu Val 
                1045                1050                1055    
Leu Glu Thr Thr Ala Pro Gly Val Glu Asp Ile Ser Gly Leu Pro Ser 
            1060                1065                1070        
Gly Glu Val Leu Glu Thr Ala Ala Pro Gly Val Glu Asp Ile Ser Gly 
        1075                1080                1085            
Leu Pro Ser Gly Glu Val Leu Glu Thr Ala Ala Pro Gly Val Glu Asp 
    1090                1095                1100                
Ile Ser Gly Leu Pro Ser Gly Glu Val Leu Glu Thr Ala Ala Pro Gly 
1105                1110                1115                1120
Val Glu Asp Ile Ser Gly Leu Pro Ser Gly Glu Val Leu Glu Thr Ala 
                1125                1130                1135    
Ala Pro Gly Val Glu Asp Ile Ser Gly Leu Pro Ser Gly Glu Val Leu 
            1140                1145                1150        
Glu Thr Ala Ala Pro Gly Val Glu Asp Ile Ser Gly Leu Pro Ser Gly 
        1155                1160                1165            
Glu Val Leu Glu Thr Ala Ala Pro Gly Val Glu Asp Ile Ser Gly Leu 
    1170                1175                1180                
Pro Ser Gly Glu Val Leu Glu Thr Ala Ala Pro Gly Val Glu Asp Ile 
1185                1190                1195                1200
Ser Gly Leu Pro Ser Gly Glu Val Leu Glu Thr Ala Ala Pro Gly Val 
                1205                1210                1215    
Glu Asp Ile Ser Gly Leu Pro Ser Gly Glu Val Leu Glu Thr Ala Ala 
            1220                1225                1230        
Pro Gly Val Glu Asp Ile Ser Gly Leu Pro Ser Gly Glu Val Leu Glu 
        1235                1240                1245            
Thr Ala Ala Pro Gly Val Glu Asp Ile Ser Gly Leu Pro Ser Gly Glu 
    1250                1255                1260                
Val Leu Glu Thr Ala Ala Pro Gly Val Glu Asp Ile Ser Gly Leu Pro 
1265                1270                1275                1280
Ser Gly Glu Val Leu Glu Thr Thr Ala Pro Gly Val Glu Glu Ile Ser 
                1285                1290                1295    
Gly Leu Pro Ser Gly Glu Val Leu Glu Thr Thr Ala Pro Gly Val Asp 
            1300                1305                1310        
Glu Ile Ser Gly Leu Pro Ser Gly Glu Val Leu Glu Thr Thr Ala Pro 
        1315                1320                1325            
Gly Val Glu Glu Ile Ser Gly Leu Pro Ser Gly Glu Val Leu Glu Thr 
    1330                1335                1340                
Ser Thr Ser Ala Val Gly Asp Leu Ser Gly Leu Pro Ser Gly Gly Glu 
1345                1350                1355                1360
Val Leu Glu Ile Ser Val Ser Gly Val Glu Asp Ile Ser Gly Leu Pro 
                1365                1370                1375    
Ser Gly Glu Val Val Glu Thr Ser Ala Ser Gly Ile Glu Asp Val Ser 
            1380                1385                1390        
Glu Leu Pro Ser Gly Glu Gly Leu Glu Thr Ser Ala Ser Gly Val Glu 
        1395                1400                1405            
Asp Leu Ser Arg Leu Pro Ser Gly Glu Glu Val Leu Glu Ile Ser Ala 
    1410                1415                1420                
Ser Gly Phe Gly Asp Leu Ser Gly Val Pro Ser Gly Gly Glu Gly Leu 
1425                1430                1435                1440
Glu Thr Ser Ala Ser Glu Val Gly Thr Asp Leu Ser Gly Leu Pro Ser 
                1445                1450                1455    
Gly Arg Glu Gly Leu Glu Thr Ser Ala Ser Gly Ala Glu Asp Leu Ser 
            1460                1465                1470        
Gly Leu Pro Ser Gly Lys Glu Asp Leu Val Gly Ser Ala Ser Gly Asp 
        1475                1480                1485            
Leu Asp Leu Gly Lys Leu Pro Ser Gly Thr Leu Gly Ser Gly Gln Ala 
    1490                1495                1500                
Pro Glu Thr Ser Gly Leu Pro Ser Gly Phe Ser Gly Glu Tyr Ser Gly 
1505                1510                1515                1520
Val Asp Leu Gly Ser Gly Pro Pro Ser Gly Leu Pro Asp Phe Ser Gly 
                1525                1530                1535    
Leu Pro Ser Gly Phe Pro Thr Val Ser Leu Val Asp Ser Thr Leu Val 
            1540                1545                1550        
Glu Val Val Thr Ala Ser Thr Ala Ser Glu Leu Glu Gly Arg Gly Thr 
        1555                1560                1565            
Ile Gly Ile Ser Gly Ala Gly Glu Ile Ser Gly Leu Pro Ser Ser Glu 
    1570                1575                1580                
Leu Asp Ile Ser Gly Arg Ala Ser Gly Leu Pro Ser Gly Thr Glu Leu 
1585                1590                1595                1600
Ser Gly Gln Ala Ser Gly Ser Pro Asp Val Ser Gly Glu Ile Pro Gly 
                1605                1610                1615    
Leu Phe Gly Val Ser Gly Gln Pro Ser Gly Phe Pro Asp Thr Ser Gly 
            1620                1625                1630        
Glu Thr Ser Gly Val Thr Glu Leu Ser Gly Leu Ser Ser Gly Gln Pro 
        1635                1640                1645            
Gly Val Ser Gly Glu Ala Ser Gly Val Leu Tyr Gly Thr Ser Gln Pro 
    1650                1655                1660                
Phe Gly Ile Thr Asp Leu Ser Gly Glu Thr Ser Gly Val Pro Asp Leu 
1665                1670                1675                1680
Ser Gly Gln Pro Ser Gly Leu Pro Gly Phe Ser Gly Ala Thr Ser Gly 
                1685                1690                1695    
Val Pro Asp Leu Val Ser Gly Thr Thr Ser Gly Ser Gly Glu Ser Ser 
            1700                1705                1710        
Gly Ile Thr Phe Val Asp Thr Ser Leu Val Glu Val Ala Pro Thr Thr 
        1715                1720                1725            
Phe Lys Glu Glu Glu Gly Leu Gly Ser Val Glu Leu Ser Gly Leu Pro 
    1730                1735                1740                
Ser Gly Glu Ala Asp Leu Ser Gly Lys Ser Gly Met Val Asp Val Ser 
1745                1750                1755                1760
Gly Gln Phe Ser Gly Thr Val Asp Ser Ser Gly Phe Thr Ser Gln Thr 
                1765                1770                1775    
Pro Glu Phe Ser Gly Leu Pro Ser Gly Ile Ala Glu Val Ser Gly Glu 
            1780                1785                1790        
Ser Ser Arg Ala Glu Ile Gly Ser Ser Leu Pro Ser Gly Ala Tyr Tyr 
        1795                1800                1805            
Gly Ser Gly Thr Pro Ser Ser Phe Pro Thr Val Ser Leu Val Asp Arg 
    1810                1815                1820                
Thr Leu Val Glu Ser Val Thr Gln Ala Pro Thr Ala Gln Glu Ala Gly 
1825                1830                1835                1840
Glu Gly Pro Ser Gly Ile Leu Glu Leu Ser Gly Ala His Ser Gly Ala 
                1845                1850                1855    
Pro Asp Met Ser Gly Glu His Ser Gly Phe Leu Asp Leu Ser Gly Leu 
            1860                1865                1870        
Gln Ser Gly Leu Ile Glu Pro Ser Gly Glu Pro Pro Gly Thr Pro Tyr 
        1875                1880                1885            
Phe Ser Gly Asp Phe Ala Ser Thr Thr Asn Val Ser Gly Glu Ser Ser 
    1890                1895                1900                
Val Ala Met Gly Thr Ser Gly Glu Ala Ser Gly Leu Pro Glu Val Thr 
1905                1910                1915                1920
Leu Ile Thr Ser Glu Phe Val Glu Gly Val Thr Glu Pro Thr Ile Ser 
                1925                1930                1935    
Gln Glu Leu Gly Gln Arg Pro Pro Val Thr His Thr Pro Gln Leu Phe 
            1940                1945                1950        
Glu Ser Ser Gly Lys Val Ser Thr Ala Gly Asp Ile Ser Gly Ala Thr 
        1955                1960                1965            
Pro Val Leu Pro Gly Ser Gly Val Glu Val Ser Ser Val Pro Glu Ser 
    1970                1975                1980                
Ser Ser Glu Thr Ser Ala Tyr Pro Glu Ala Gly Phe Gly Ala Ser Ala 
1985                1990                1995                2000
Ala Pro Glu Ala Ser Arg Glu Asp Ser Gly Ser Pro Asp Leu Ser Glu 
                2005                2010                2015    
Thr Thr Ser Ala Phe His Glu Ala Asn Leu Glu Arg Ser Ser Gly Leu 
            2020                2025                2030        
Gly Val Ser Gly Ser Thr Leu Thr Phe Gln Glu Gly Glu Ala Ser Ala 
        2035                2040                2045            
Ala Pro Glu Val Ser Gly Glu Ser Thr Thr Thr Ser Asp Val Gly Thr 
    2050                2055                2060                
Glu Ala Pro Gly Leu Pro Ser Ala Thr Pro Thr Ala Ser Gly Asp Arg 
2065                2070                2075                2080
Thr Glu Ile Ser Gly Asp Leu Ser Gly His Thr Ser Gln Leu Gly Val 
                2085                2090                2095    
Val Ile Ser Thr Ser Ile Pro Glu Ser Glu Trp Thr Gln Gln Thr Gln 
            2100                2105                2110        
Arg Pro Ala Glu Thr His Leu Glu Ile Glu Ser Ser Ser Leu Leu Tyr 
        2115                2120                2125            
Ser Gly Glu Glu Thr His Thr Val Glu Thr Ala Thr Ser Pro Thr Asp 
    2130                2135                2140                
Ala Ser Ile Pro Ala Ser Pro Glu Trp Lys Arg Glu Ser Glu Ser Thr 
2145                2150                2155                2160
Ala Ala Ala Pro Ala Arg Ser Cys Ala Glu Glu Pro Cys Gly Ala Gly 
                2165                2170                2175    
Thr Cys Lys Glu Thr Glu Gly His Val Ile Cys Leu Cys Pro Pro Gly 
            2180                2185                2190        
Tyr Thr Gly Glu His Cys Asn Ile Asp Gln Glu Val Cys Glu Glu Gly 
        2195                2200                2205            
Trp Asn Lys Tyr Gln Gly His Cys Tyr Arg His Phe Pro Asp Arg Glu 
    2210                2215                2220                
Thr Trp Val Asp Ala Glu Arg Arg Cys Arg Glu Gln Gln Ser His Leu 
2225                2230                2235                2240
Ser Ser Ile Val Thr Pro Glu Glu Gln Glu Phe Val Asn Asn Asn Ala 
                2245                2250                2255    
Gln Asp Tyr Gln Trp Ile Gly Leu Asn Asp Arg Thr Ile Glu Gly Asp 
            2260                2265                2270        
Phe Arg Trp Ser Asp Gly His Pro Met Gln Phe Glu Asn Trp Arg Pro 
        2275                2280                2285            
Asn Gln Pro Asp Asn Phe Phe Ala Ala Gly Glu Asp Cys Val Val Met 
    2290                2295                2300                
Ile Trp His Glu Lys Gly Glu Trp Asn Asp Val Pro Cys Asn Tyr His 
2305                2310                2315                2320
Leu Pro Phe Thr Cys Lys Lys Gly Thr Val Ala Cys Gly Glu Pro Pro 
                2325                2330                2335    
Val Val Glu His Ala Arg Thr Phe Gly Gln Lys Lys Asp Arg Tyr Glu 
            2340                2345                2350        
Ile Asn Ser Leu Val Arg Tyr Gln Cys Thr Glu Gly Phe Val Gln Arg 
        2355                2360                2365            
His Met Pro Thr Ile Arg Cys Gln Pro Ser Gly His Trp Glu Glu Pro 
    2370                2375                2380                
Arg Ile Thr Cys Thr Asp Ala Thr Thr Tyr Lys Arg Arg Leu Gln Lys 
2385                2390                2395                2400
Arg Ser Ser Arg His Pro Arg Arg Ser Arg Pro Ser Thr Ala His 
                2405                2410                2415

