﻿                         SEQUENCE LISTING

<110>  四川大学华西医院
 
<120>  一种PDGFRβ靶向性肿瘤坏死因子相关凋亡诱导配体变异体

<130>  1

<150>  201710398226.5
<151>  2017-05-31

<160>  12    

<170>  PatentIn version 3.5

<210>  1
<211>  58
<212>  PRT
<213>  ZPDGFRβ 氨基酸序列（homo sapiens）

<400>  1

Ala Glu Asn Lys Phe Asn Lys Glu Leu Ile Glu Ala Ala Ala Glu Ile 
1               5                   10                  15      


Asp Ala Leu Pro Asn Leu Asn Arg Arg Gln Trp Asn Ala Phe Ile Lys 
            20                  25                  30          


Ser Leu Val Asp Asp Pro Ser Gln Ser Ala Asn Leu Leu Ala Glu Ala 
        35                  40                  45              


Lys Lys Leu Asn Asp Ala Gln Ala Pro Lys 
    50                  55              


<210>  2
<211>  174
<212>  DNA
<213>  ZPDGFRβ的核酸序列（homo sapiens）

<400>  2
gctgaaaaca aatttaacaa agaactgatt gaagccgctg ccgaaattga tgctctgccg       60

aacctgaacc gtcgccagtg gaatgctttt attaaatctc tggtggatga cccgagccag      120

tctgctaacc tgctggctga agcgaaaaaa ctgaatgatg cccaagcacc gaaa            174


<210>  3
<211>  168
<212>  PRT
<213>  hTRAIL的氨基酸序列（homo sapiens）

<400>  3

Val Arg Glu Arg Gly Pro Gln Arg Val Ala Ala His Ile Thr Gly Thr 
1               5                   10                  15      


Arg Gly Arg Ser Asn Thr Leu Ser Ser Pro Asn Ser Lys Asn Glu Lys 
            20                  25                  30          


Ala Leu Gly Arg Lys Ile Asn Ser Trp Glu Ser Ser Arg Ser Gly His 
        35                  40                  45              


Ser Phe Leu Ser Asn Leu His Leu Arg Asn Gly Glu Leu Val Ile His 
    50                  55                  60                  


Glu Lys Gly Phe Tyr Tyr Ile Tyr Ser Gln Thr Tyr Phe Arg Phe Gln 
65                  70                  75                  80  


Glu Glu Ile Lys Glu Asn Thr Lys Asn Asp Lys Gln Met Val Gln Tyr 
                85                  90                  95      


Ile Tyr Lys Tyr Thr Ser Tyr Pro Asp Pro Ile Leu Leu Met Lys Ser 
            100                 105                 110         


Ala Arg Asn Ser Cys Trp Ser Lys Asp Ala Glu Tyr Gly Leu Tyr Ser 
        115                 120                 125             


Ile Tyr Gln Gly Gly Ile Phe Glu Leu Lys Glu Asn Asp Arg Ile Phe 
    130                 135                 140                 


Val Ser Val Thr Asn Glu His Leu Ile Asp Met Asp His Glu Ala Ser 
145                 150                 155                 160 


Phe Phe Gly Ala Phe Leu Val Gly 
                165             


<210>  4
<211>  504
<212>  DNA
<213>  hTRAIL的核酸序列（homo sapiens）

<400>  4
gtgagagaaa gaggtcctca gagagtagca gctcacataa ctgggaccag aggaagaagc       60

aacacattgt cttctccaaa ctccaagaat gaaaaggctc tgggccgcaa aataaactcc      120

tgggaatcat caaggagtgg gcattcattc ctgagcaact tgcacttgag gaatggtgaa      180

ctggtcatcc atgaaaaagg gttttactac atctattccc aaacatactt tcgatttcag      240

gaggaaataa aagaaaacac aaagaacgac aaacaaatgg tccaatatat ttacaaatac      300

acaagttatc ctgaccctat attgttgatg aaaagtgcta gaaatagttg ttggtctaaa      360

gatgcagaat atggactcta ttccatctat caagggggaa tatttgagct taaggaaaat      420

gacagaattt ttgtttctgt aacaaatgag cacttgatag acatggacca tgaagccagt      480

tttttcgggg cctttttagt tggc                                             504


<210>  5
<211>  15
<212>  PRT
<213>  (G4S)3连接子的氨基酸序列（homo sapiens）

<400>  5

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  6
<211>  45
<212>  DNA
<213>  (G4S)3连接子的核酸序列（homo sapiens）

<400>  6
ggcggtggcg gttcaggcgg tggcggttcg ggcggtggcg gtagc                       45


<210>  7
<211>  241
<212>  PRT
<213>  Z-hTRAIL的氨基酸序列（homo sapiens）

<400>  7

Ala Glu Asn Lys Phe Asn Lys Glu Leu Ile Glu Ala Ala Ala Glu Ile 
1               5                   10                  15      


Asp Ala Leu Pro Asn Leu Asn Arg Arg Gln Trp Asn Ala Phe Ile Lys 
            20                  25                  30          


Ser Leu Val Asp Asp Pro Ser Gln Ser Ala Asn Leu Leu Ala Glu Ala 
        35                  40                  45              


Lys Lys Leu Asn Asp Ala Gln Ala Pro Lys Gly Gly Gly Gly Ser Gly 
    50                  55                  60                  


Gly Gly Gly Ser Gly Gly Gly Gly Ser Val Arg Glu Arg Gly Pro Gln 
65                  70                  75                  80  


Arg Val Ala Ala His Ile Thr Gly Thr Arg Gly Arg Ser Asn Thr Leu 
                85                  90                  95      


Ser Ser Pro Asn Ser Lys Asn Glu Lys Ala Leu Gly Arg Lys Ile Asn 
            100                 105                 110         


Ser Trp Glu Ser Ser Arg Ser Gly His Ser Phe Leu Ser Asn Leu His 
        115                 120                 125             


Leu Arg Asn Gly Glu Leu Val Ile His Glu Lys Gly Phe Tyr Tyr Ile 
    130                 135                 140                 


Tyr Ser Gln Thr Tyr Phe Arg Phe Gln Glu Glu Ile Lys Glu Asn Thr 
145                 150                 155                 160 


Lys Asn Asp Lys Gln Met Val Gln Tyr Ile Tyr Lys Tyr Thr Ser Tyr 
                165                 170                 175     


Pro Asp Pro Ile Leu Leu Met Lys Ser Ala Arg Asn Ser Cys Trp Ser 
            180                 185                 190         


Lys Asp Ala Glu Tyr Gly Leu Tyr Ser Ile Tyr Gln Gly Gly Ile Phe 
        195                 200                 205             


Glu Leu Lys Glu Asn Asp Arg Ile Phe Val Ser Val Thr Asn Glu His 
    210                 215                 220                 


Leu Ile Asp Met Asp His Glu Ala Ser Phe Phe Gly Ala Phe Leu Val 
225                 230                 235                 240 


Gly 
    


<210>  8
<211>  723
<212>  DNA
<213>  Z-hTRAIL的核酸序列（homo sapiens）

<400>  8
gctgaaaaca aatttaacaa agaactgatt gaagccgctg ccgaaattga tgctctgccg       60

aacctgaacc gtcgccagtg gaatgctttt attaaatctc tggtggatga cccgagccag      120

tctgctaacc tgctggctga agcgaaaaaa ctgaatgatg cccaagcacc gaaaggcggt      180

ggcggttcag gcggtggcgg ttcgggcggt ggcggtagcg tgagagaaag aggtcctcag      240

agagtagcag ctcacataac tgggaccaga ggaagaagca acacattgtc ttctccaaac      300

tccaagaatg aaaaggctct gggccgcaaa ataaactcct gggaatcatc aaggagtggg      360

cattcattcc tgagcaactt gcacttgagg aatggtgaac tggtcatcca tgaaaaaggg      420

ttttactaca tctattccca aacatacttt cgatttcagg aggaaataaa agaaaacaca      480

aagaacgaca aacaaatggt ccaatatatt tacaaataca caagttatcc tgaccctata      540

ttgttgatga aaagtgctag aaatagttgt tggtctaaag atgcagaata tggactctat      600

tccatctatc aagggggaat atttgagctt aaggaaaatg acagaatttt tgtttctgta      660

acaaatgagc acttgataga catggaccat gaagccagtt ttttcggggc ctttttagtt      720

ggc                                                                    723


<210>  9
<211>  58
<212>  PRT
<213>  ZFcRn的氨基酸序列（homo sapiens）

<400>  9

Val Asp Ala Lys Tyr Ala Lys Glu Phe Glu Ser Ala Ala His Glu Ile 
1               5                   10                  15      


Arg Trp Leu Pro Asn Leu Thr Tyr Asp Gln Arg Val Ala Phe Ile His 
            20                  25                  30          


Lys Leu Ser Asp Asp Pro Ser Gln Ser Ser Glu Leu Leu Ser Glu Ala 
        35                  40                  45              


Lys Lys Leu Asn Asp Ser Gln Ala Pro Lys 
    50                  55              


<210>  10
<211>  174
<212>  DNA
<213>  ZFcRn的核酸序列（homo sapiens）

<400>  10
gttgatgcga aatatgcgaa agaatttgaa agcgcggccc atgaaatccg ttggctgccg       60

aatctgacct acgaccagcg tgttgctttt attcataaac tgagtgatga cccgtcccag      120

agctctgaac tgctgagcga agcgaaaaaa ctgaacgatt cccaagcccc gaaa            174


<210>  11
<211>  241
<212>  PRT
<213>  Zf-hTRAIL的氨基酸序列（homo sapiens）

<400>  11

Val Asp Ala Lys Tyr Ala Lys Glu Phe Glu Ser Ala Ala His Glu Ile 
1               5                   10                  15      


Arg Trp Leu Pro Asn Leu Thr Tyr Asp Gln Arg Val Ala Phe Ile His 
            20                  25                  30          


Lys Leu Ser Asp Asp Pro Ser Gln Ser Ser Glu Leu Leu Ser Glu Ala 
        35                  40                  45              


Lys Lys Leu Asn Asp Ser Gln Ala Pro Lys Gly Gly Gly Gly Ser Gly 
    50                  55                  60                  


Gly Gly Gly Ser Gly Gly Gly Gly Ser Val Arg Glu Arg Gly Pro Gln 
65                  70                  75                  80  


Arg Val Ala Ala His Ile Thr Gly Thr Arg Gly Arg Ser Asn Thr Leu 
                85                  90                  95      


Ser Ser Pro Asn Ser Lys Asn Glu Lys Ala Leu Gly Arg Lys Ile Asn 
            100                 105                 110         


Ser Trp Glu Ser Ser Arg Ser Gly His Ser Phe Leu Ser Asn Leu His 
        115                 120                 125             


Leu Arg Asn Gly Glu Leu Val Ile His Glu Lys Gly Phe Tyr Tyr Ile 
    130                 135                 140                 


Tyr Ser Gln Thr Tyr Phe Arg Phe Gln Glu Glu Ile Lys Glu Asn Thr 
145                 150                 155                 160 


Lys Asn Asp Lys Gln Met Val Gln Tyr Ile Tyr Lys Tyr Thr Ser Tyr 
                165                 170                 175     


Pro Asp Pro Ile Leu Leu Met Lys Ser Ala Arg Asn Ser Cys Trp Ser 
            180                 185                 190         


Lys Asp Ala Glu Tyr Gly Leu Tyr Ser Ile Tyr Gln Gly Gly Ile Phe 
        195                 200                 205             


Glu Leu Lys Glu Asn Asp Arg Ile Phe Val Ser Val Thr Asn Glu His 
    210                 215                 220                 


Leu Ile Asp Met Asp His Glu Ala Ser Phe Phe Gly Ala Phe Leu Val 
225                 230                 235                 240 


Gly 
    


<210>  12
<211>  723
<212>  DNA
<213>  Zf-hTRAIL的核酸序列（homo sapiens）

<400>  12
gttgatgcga aatatgcgaa agaatttgaa agcgcggccc atgaaatccg ttggctgccg       60

aatctgacct acgaccagcg tgttgctttt attcataaac tgagtgatga cccgtcccag      120

agctctgaac tgctgagcga agcgaaaaaa ctgaacgatt cccaagcccc gaaaggcggt      180

ggcggttcag gcggtggcgg ttcgggcggt ggcggtagcg tgagagaaag aggtcctcag      240

agagtagcag ctcacataac tgggaccaga ggaagaagca acacattgtc ttctccaaac      300

tccaagaatg aaaaggctct gggccgcaaa ataaactcct gggaatcatc aaggagtggg      360

cattcattcc tgagcaactt gcacttgagg aatggtgaac tggtcatcca tgaaaaaggg      420

ttttactaca tctattccca aacatacttt cgatttcagg aggaaataaa agaaaacaca      480

aagaacgaca aacaaatggt ccaatatatt tacaaataca caagttatcc tgaccctata      540

ttgttgatga aaagtgctag aaatagttgt tggtctaaag atgcagaata tggactctat      600

tccatctatc aagggggaat atttgagctt aaggaaaatg acagaatttt tgtttctgta      660

acaaatgagc acttgataga catggaccat gaagccagtt ttttcggggc ctttttagtt      720

ggc                                                                    723


