                         SEQUENCE LISTING

<110>  Fred Hutchinson Cancer Research Center
 
<120>  ANTI-CD33 ANTIBODIES

<130>  F053-0060PCT/17-036-WO-PCT

<150>  US 62/511,792
<151>  2017-05-26

<150>  US 62/532,772
<151>  2017-07-14

<160>  157   

<170>  PatentIn version 3.5

<210>  1
<211>  481
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence of human full-length CD33 (MDT000208; 
       hsCD33-mmFc; Immunogen for human full-length)

<400>  1

Met Pro Leu Leu Leu Leu Leu Pro Leu Leu Trp Ala Gly Ala Leu Ala 
1               5                   10                  15      


Met Asp Pro Asn Phe Trp Leu Gln Val Gln Glu Ser Val Thr Val Gln 
            20                  25                  30          


Glu Gly Leu Cys Val Leu Val Pro Cys Thr Phe Phe His Pro Ile Pro 
        35                  40                  45              


Tyr Tyr Asp Lys Asn Ser Pro Val His Gly Tyr Trp Phe Arg Glu Gly 
    50                  55                  60                  


Ala Ile Ile Ser Arg Asp Ser Pro Val Ala Thr Asn Lys Leu Asp Gln 
65                  70                  75                  80  


Glu Val Gln Glu Glu Thr Gln Gly Arg Phe Arg Leu Leu Gly Asp Pro 
                85                  90                  95      


Ser Arg Asn Asn Cys Ser Leu Ser Ile Val Asp Ala Arg Arg Arg Asp 
            100                 105                 110         


Asn Gly Ser Tyr Phe Phe Arg Met Glu Arg Gly Ser Thr Lys Tyr Ser 
        115                 120                 125             


Tyr Lys Ser Pro Gln Leu Ser Val His Val Thr Asp Leu Thr His Arg 
    130                 135                 140                 


Pro Lys Ile Leu Ile Pro Gly Thr Leu Glu Pro Gly His Ser Lys Asn 
145                 150                 155                 160 


Leu Thr Cys Ser Val Ser Trp Ala Cys Glu Gln Gly Thr Pro Pro Ile 
                165                 170                 175     


Phe Ser Trp Leu Ser Ala Ala Pro Thr Ser Leu Gly Pro Arg Thr Thr 
            180                 185                 190         


His Ser Ser Val Leu Ile Ile Thr Pro Arg Pro Gln Asp His Gly Thr 
        195                 200                 205             


Asn Leu Thr Cys Gln Val Lys Phe Ala Gly Ala Gly Val Thr Thr Glu 
    210                 215                 220                 


Arg Thr Ile Gln Leu Asn Val Thr Tyr Val Pro Gln Asn Pro Thr Thr 
225                 230                 235                 240 


Gly Ile Phe Pro Gly Asp Gly Ser Gly Lys Gln Glu Thr Arg Ala Gly 
                245                 250                 255     


Gly Gly Ser Gly Cys Lys Pro Cys Ile Cys Thr Val Pro Glu Val Ser 
            260                 265                 270         


Ser Val Phe Ile Phe Pro Pro Lys Pro Lys Asp Val Leu Thr Ile Thr 
        275                 280                 285             


Leu Thr Pro Lys Val Thr Cys Val Val Val Asp Ile Ser Lys Asp Asp 
    290                 295                 300                 


Pro Glu Val Gln Phe Ser Trp Phe Val Asp Asp Val Glu Val His Thr 
305                 310                 315                 320 


Ala Gln Thr Gln Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg Ser 
                325                 330                 335     


Val Ser Glu Leu Pro Ile Met His Gln Asp Trp Leu Asn Gly Lys Glu 
            340                 345                 350         


Phe Lys Cys Arg Val Asn Ser Ala Ala Phe Pro Ala Pro Ile Glu Lys 
        355                 360                 365             


Thr Ile Ser Lys Thr Lys Gly Arg Pro Lys Ala Pro Gln Val Tyr Thr 
    370                 375                 380                 


Ile Pro Pro Pro Lys Glu Gln Met Ala Lys Asp Lys Val Ser Leu Thr 
385                 390                 395                 400 


Cys Met Ile Thr Asp Phe Phe Pro Glu Asp Ile Thr Val Glu Trp Gln 
                405                 410                 415     


Trp Asn Gly Gln Pro Ala Glu Asn Tyr Lys Asn Thr Gln Pro Ile Met 
            420                 425                 430         


Asn Thr Asn Gly Ser Tyr Phe Val Tyr Ser Lys Leu Asn Val Gln Lys 
        435                 440                 445             


Ser Asn Trp Glu Ala Gly Asn Thr Phe Thr Cys Ser Val Leu His Glu 
    450                 455                 460                 


Gly Leu His Asn His His Thr Glu Lys Ser Leu Ser His Ser Pro Gly 
465                 470                 475                 480 


Lys 
    


<210>  2
<211>  244
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence of human DeltaE2 version of CD33 with a mouse
       Fc domain

<400>  2

Met Pro Leu Leu Leu Leu Leu Pro Leu Leu Trp Ala Asp Leu Thr His 
1               5                   10                  15      


Arg Pro Lys Ile Leu Ile Pro Gly Thr Leu Glu Pro Gly His Ser Lys 
            20                  25                  30          


Asn Leu Thr Cys Ser Val Ser Trp Ala Cys Glu Gln Gly Thr Pro Pro 
        35                  40                  45              


Ile Phe Ser Trp Leu Ser Ala Ala Pro Thr Ser Leu Gly Pro Arg Thr 
    50                  55                  60                  


Thr His Ser Ser Val Leu Ile Ile Thr Pro Arg Pro Gln Asp His Gly 
65                  70                  75                  80  


Thr Asn Leu Thr Cys Gln Val Lys Phe Ala Gly Ala Gly Val Thr Thr 
                85                  90                  95      


Glu Arg Thr Ile Gln Leu Asn Val Thr Tyr Val Pro Gln Asn Pro Thr 
            100                 105                 110         


Thr Gly Ile Phe Pro Gly Asp Gly Ser Gly Lys Gln Glu Thr Arg Ala 
        115                 120                 125             


Gly Gly Gly Ser Gly Cys Lys Pro Cys Ile Cys Thr Val Pro Glu Val 
    130                 135                 140                 


Ser Ser Val Phe Ile Phe Pro Pro Lys Pro Lys Asp Val Leu Thr Ile 
145                 150                 155                 160 


Thr Leu Thr Pro Lys Val Thr Cys Val Val Val Asp Ile Ser Lys Asp 
                165                 170                 175     


Asp Pro Glu Val Gln Phe Ser Trp Phe Val Asp Asp Val Glu Val His 
            180                 185                 190         


Thr Ala Gln Thr Gln Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg 
        195                 200                 205             


Ser Val Ser Glu Leu Pro Ile Met His Gln Asp Trp Leu Asn Gly Lys 
    210                 215                 220                 


Glu Phe Lys Cys Arg Val Asn Ser Ala Ala Phe Pro Ala Pro Ile Glu 
225                 230                 235                 240 


Lys Thr Ile Ser 
                


<210>  3
<211>  480
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence of Macaca fascicularis CD33 full-length with 
       a mouse Fc domain

<400>  3

Met Pro Leu Leu Leu Leu Pro Leu Leu Trp Ala Gly Ala Leu Ala Met 
1               5                   10                  15      


Asp Pro Arg Val Arg Leu Glu Val Gln Glu Ser Val Thr Val Gln Glu 
            20                  25                  30          


Gly Leu Cys Val Leu Val Pro Cys Thr Phe Phe His Pro Val Pro Tyr 
        35                  40                  45              


His Thr Arg Asn Ser Pro Val His Gly Tyr Trp Phe Arg Glu Gly Ala 
    50                  55                  60                  


Ile Val Ser Leu Asp Ser Pro Val Ala Thr Asn Lys Leu Asp Gln Glu 
65                  70                  75                  80  


Val Gln Glu Glu Thr Gln Gly Arg Phe Arg Leu Leu Gly Asp Pro Ser 
                85                  90                  95      


Arg Asn Asn Cys Ser Leu Ser Ile Val Asp Ala Arg Arg Arg Asp Asn 
            100                 105                 110         


Gly Ser Tyr Phe Phe Arg Met Glu Lys Gly Ser Thr Lys Tyr Ser Tyr 
        115                 120                 125             


Lys Ser Thr Gln Leu Ser Val His Val Thr Asp Leu Thr His Arg Pro 
    130                 135                 140                 


Gln Ile Leu Ile Pro Gly Ala Leu Asp Pro Asp His Ser Lys Asn Leu 
145                 150                 155                 160 


Thr Cys Ser Val Pro Trp Ala Cys Glu Gln Gly Thr Pro Pro Ile Phe 
                165                 170                 175     


Ser Trp Met Ser Ala Ala Pro Thr Ser Leu Gly Leu Arg Thr Thr His 
            180                 185                 190         


Ser Ser Val Leu Ile Ile Thr Pro Arg Pro Gln Asp His Gly Thr Asn 
        195                 200                 205             


Leu Thr Cys Gln Val Lys Phe Pro Gly Ala Gly Val Thr Thr Glu Arg 
    210                 215                 220                 


Thr Ile Gln Leu Asn Val Ser Tyr Ala Ser Gln Asn Pro Arg Thr Asp 
225                 230                 235                 240 


Ile Phe Leu Gly Asp Gly Ser Gly Arg Lys Ala Arg Lys Gln Gly Gly 
                245                 250                 255     


Gly Ser Gly Cys Lys Pro Cys Ile Cys Thr Val Pro Glu Val Ser Ser 
            260                 265                 270         


Val Phe Ile Phe Pro Pro Lys Pro Lys Asp Val Leu Thr Ile Thr Leu 
        275                 280                 285             


Thr Pro Lys Val Thr Cys Val Val Val Asp Ile Ser Lys Asp Asp Pro 
    290                 295                 300                 


Glu Val Gln Phe Ser Trp Phe Val Asp Asp Val Glu Val His Thr Ala 
305                 310                 315                 320 


Gln Thr Gln Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg Ser Val 
                325                 330                 335     


Ser Glu Leu Pro Ile Met His Gln Asp Trp Leu Asn Gly Lys Glu Phe 
            340                 345                 350         


Lys Cys Arg Val Asn Ser Ala Ala Phe Pro Ala Pro Ile Glu Lys Thr 
        355                 360                 365             


Ile Ser Lys Thr Lys Gly Arg Pro Lys Ala Pro Gln Val Tyr Thr Ile 
    370                 375                 380                 


Pro Pro Pro Lys Glu Gln Met Ala Lys Asp Lys Val Ser Leu Thr Cys 
385                 390                 395                 400 


Met Ile Thr Asp Phe Phe Pro Glu Asp Ile Thr Val Glu Trp Gln Trp 
                405                 410                 415     


Asn Gly Gln Pro Ala Glu Asn Tyr Lys Asn Thr Gln Pro Ile Met Asn 
            420                 425                 430         


Thr Asn Gly Ser Tyr Phe Val Tyr Ser Lys Leu Asn Val Gln Lys Ser 
        435                 440                 445             


Asn Trp Glu Ala Gly Asn Thr Phe Thr Cys Ser Val Leu His Glu Gly 
    450                 455                 460                 


Leu His Asn His His Thr Glu Lys Ser Leu Ser His Ser Pro Gly Lys 
465                 470                 475                 480 


<210>  4
<211>  489
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence of the extracellular domain of mouse CD33 
       full length where the C2-set Ig-like domain from mouse has been 
       replaced with the C2-set Ig-like domain from human CD33, combined
       with a with a Fc region from human IgG1

<400>  4

Met Leu Trp Pro Leu Pro Leu Phe Leu Leu Cys Ala Gly Ser Leu Ala 
1               5                   10                  15      


Gln Asp Leu Glu Phe Gln Leu Val Ala Pro Glu Ser Val Thr Val Glu 
            20                  25                  30          


Glu Gly Leu Cys Val His Val Pro Cys Ser Val Phe Tyr Pro Ser Ile 
        35                  40                  45              


Lys Leu Thr Leu Gly Pro Val Thr Gly Ser Trp Leu Arg Lys Gly Val 
    50                  55                  60                  


Ser Leu His Glu Asp Ser Pro Val Ala Thr Ser Asp Pro Arg Gln Leu 
65                  70                  75                  80  


Val Gln Lys Ala Thr Gln Gly Arg Phe Gln Leu Leu Gly Asp Pro Gln 
                85                  90                  95      


Lys His Asp Cys Ser Leu Phe Ile Arg Asp Ala Gln Lys Asn Asp Thr 
            100                 105                 110         


Gly Met Tyr Phe Phe Arg Val Val Arg Glu Pro Phe Val Arg Tyr Ser 
        115                 120                 125             


Tyr Lys Lys Ser Gln Leu Ser Leu His Val Thr Asp Leu Thr His Arg 
    130                 135                 140                 


Pro Lys Ile Leu Ile Pro Gly Thr Leu Glu Pro Gly His Ser Lys Asn 
145                 150                 155                 160 


Leu Thr Cys Ser Val Ser Trp Ala Cys Glu Gln Gly Thr Pro Pro Ile 
                165                 170                 175     


Phe Ser Trp Leu Ser Ala Ala Pro Thr Ser Leu Gly Pro Arg Thr Thr 
            180                 185                 190         


His Ser Ser Val Leu Ile Ile Thr Pro Arg Pro Gln Asp His Gly Thr 
        195                 200                 205             


Asn Leu Thr Cys Gln Val Lys Phe Ala Gly Ala Gly Val Thr Thr Glu 
    210                 215                 220                 


Arg Thr Ile Gln Leu Asn Val Thr Tyr Val Pro Gln Asn Pro Thr Thr 
225                 230                 235                 240 


Gly Ile Phe Pro Gly Asp Gly Ser Gly Lys Gln Glu Thr Arg Ala Gly 
                245                 250                 255     


Ser Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
            260                 265                 270         


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
        275                 280                 285             


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
    290                 295                 300                 


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
305                 310                 315                 320 


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
                325                 330                 335     


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
            340                 345                 350         


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
        355                 360                 365             


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
    370                 375                 380                 


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu 
385                 390                 395                 400 


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
                405                 410                 415     


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
            420                 425                 430         


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
        435                 440                 445             


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
    450                 455                 460                 


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
465                 470                 475                 480 


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                485                 


<210>  5
<211>  280
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence of the extracellular domain of CD33 
       full-length with a 6-histidine-avidin tag

<400>  5

Met Pro Leu Leu Leu Leu Leu Pro Leu Leu Trp Ala Gly Ala Leu Ala 
1               5                   10                  15      


Met Asp Pro Asn Phe Trp Leu Gln Val Gln Glu Ser Val Thr Val Gln 
            20                  25                  30          


Glu Gly Leu Cys Val Leu Val Pro Cys Thr Phe Phe His Pro Ile Pro 
        35                  40                  45              


Tyr Tyr Asp Lys Asn Ser Pro Val His Gly Tyr Trp Phe Arg Glu Gly 
    50                  55                  60                  


Ala Ile Ile Ser Arg Asp Ser Pro Val Ala Thr Asn Lys Leu Asp Gln 
65                  70                  75                  80  


Glu Val Gln Glu Glu Thr Gln Gly Arg Phe Arg Leu Leu Gly Asp Pro 
                85                  90                  95      


Ser Arg Asn Asn Cys Ser Leu Ser Ile Val Asp Ala Arg Arg Arg Asp 
            100                 105                 110         


Asn Gly Ser Tyr Phe Phe Arg Met Glu Arg Gly Ser Thr Lys Tyr Ser 
        115                 120                 125             


Tyr Lys Ser Pro Gln Leu Ser Val His Val Thr Asp Leu Thr His Arg 
    130                 135                 140                 


Pro Lys Ile Leu Ile Pro Gly Thr Leu Glu Pro Gly His Ser Lys Asn 
145                 150                 155                 160 


Leu Thr Cys Ser Val Ser Trp Ala Cys Glu Gln Gly Thr Pro Pro Ile 
                165                 170                 175     


Phe Ser Trp Leu Ser Ala Ala Pro Thr Ser Leu Gly Pro Arg Thr Thr 
            180                 185                 190         


His Ser Ser Val Leu Ile Ile Thr Pro Arg Pro Gln Asp His Gly Thr 
        195                 200                 205             


Asn Leu Thr Cys Gln Val Lys Phe Ala Gly Ala Gly Val Thr Thr Glu 
    210                 215                 220                 


Arg Thr Ile Gln Leu Asn Val Thr Tyr Val Pro Gln Asn Pro Thr Thr 
225                 230                 235                 240 


Gly Ile Phe Pro Gly Asp Gly Ser Gly Lys Gln Glu Thr Arg Ala Gly 
                245                 250                 255     


Ser His His His His His His Gly Ser Gly Leu Asn Asp Ile Phe Glu 
            260                 265                 270         


Ala Gln Lys Ile Glu Trp His Glu 
        275                 280 


<210>  6
<211>  279
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence of the extracellular domain of Macaque 
       fascicularis CD33 full-length with a 6-histidine-avidin tag

<400>  6

Met Pro Leu Leu Leu Leu Pro Leu Leu Trp Ala Gly Ala Leu Ala Met 
1               5                   10                  15      


Asp Pro Arg Val Arg Leu Glu Val Gln Glu Ser Val Thr Val Gln Glu 
            20                  25                  30          


Gly Leu Cys Val Leu Val Pro Cys Thr Phe Phe His Pro Val Pro Tyr 
        35                  40                  45              


His Thr Arg Asn Ser Pro Val His Gly Tyr Trp Phe Arg Glu Gly Ala 
    50                  55                  60                  


Ile Val Ser Leu Asp Ser Pro Val Ala Thr Asn Lys Leu Asp Gln Glu 
65                  70                  75                  80  


Val Gln Glu Glu Thr Gln Gly Arg Phe Arg Leu Leu Gly Asp Pro Ser 
                85                  90                  95      


Arg Asn Asn Cys Ser Leu Ser Ile Val Asp Ala Arg Arg Arg Asp Asn 
            100                 105                 110         


Gly Ser Tyr Phe Phe Arg Met Glu Lys Gly Ser Thr Lys Tyr Ser Tyr 
        115                 120                 125             


Lys Ser Thr Gln Leu Ser Val His Val Thr Asp Leu Thr His Arg Pro 
    130                 135                 140                 


Gln Ile Leu Ile Pro Gly Ala Leu Asp Pro Asp His Ser Lys Asn Leu 
145                 150                 155                 160 


Thr Cys Ser Val Pro Trp Ala Cys Glu Gln Gly Thr Pro Pro Ile Phe 
                165                 170                 175     


Ser Trp Met Ser Ala Ala Pro Thr Ser Leu Gly Leu Arg Thr Thr His 
            180                 185                 190         


Ser Ser Val Leu Ile Ile Thr Pro Arg Pro Gln Asp His Gly Thr Asn 
        195                 200                 205             


Leu Thr Cys Gln Val Lys Phe Pro Gly Ala Gly Val Thr Thr Glu Arg 
    210                 215                 220                 


Thr Ile Gln Leu Asn Val Ser Tyr Ala Ser Gln Asn Pro Arg Thr Asp 
225                 230                 235                 240 


Ile Phe Leu Gly Asp Gly Ser Gly Arg Lys Ala Arg Lys Gln Gly Ser 
                245                 250                 255     


His His His His His His Gly Ser Gly Leu Asn Asp Ile Phe Glu Ala 
            260                 265                 270         


Gln Lys Ile Glu Trp His Glu 
        275                 


<210>  7
<211>  153
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence of the extracellular domain of CD33DeltaE2 
       with a 6-histidine-avidin tag

<400>  7

Met Pro Leu Leu Leu Leu Leu Pro Leu Leu Trp Ala Asp Leu Thr His 
1               5                   10                  15      


Arg Pro Lys Ile Leu Ile Pro Gly Thr Leu Glu Pro Gly His Ser Lys 
            20                  25                  30          


Asn Leu Thr Cys Ser Val Ser Trp Ala Ser Glu Gln Gly Thr Pro Pro 
        35                  40                  45              


Ile Phe Ser Trp Leu Ser Ala Ala Pro Thr Ser Leu Gly Pro Arg Thr 
    50                  55                  60                  


Thr His Ser Ser Val Leu Ile Ile Thr Pro Arg Pro Gln Asp His Gly 
65                  70                  75                  80  


Thr Asn Leu Thr Cys Gln Val Lys Phe Ala Gly Ala Gly Val Thr Thr 
                85                  90                  95      


Glu Arg Thr Ile Gln Leu Asn Val Thr Tyr Val Pro Gln Asn Pro Thr 
            100                 105                 110         


Thr Gly Ile Phe Pro Gly Asp Gly Ser Gly Lys Gln Glu Thr Arg Ala 
        115                 120                 125             


Gly Ser His His His His His His Gly Ser Gly Leu Asn Asp Ile Phe 
    130                 135                 140                 


Glu Ala Gln Lys Ile Glu Trp His Glu 
145                 150             


<210>  8
<211>  234
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence of the light chain of IgG2a anti-CD33 
       antibody 5D12

<400>  8

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ile Lys Met Thr Gln Ser Pro Ser Ser Ile Tyr 
            20                  25                  30          


Ala Ser Leu Gly Glu Arg Val Thr Ile Asn Cys Lys Ala Ser Gln Asp 
        35                  40                  45              


Ile Lys Ser Tyr Leu Ser Trp Tyr Gln Gln Lys Pro Trp Lys Ser Pro 
    50                  55                  60                  


Lys Thr Leu Ile Tyr Tyr Ala Thr Thr Leu Ala Asp Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Gly Ser Gly Gln Asp Tyr Ser Leu Thr Ile Ser 
                85                  90                  95      


Ser Leu Glu Ser Asp Asp Thr Ala Thr Tyr Tyr Cys Leu His His Gly 
            100                 105                 110         


Glu Ser Pro Trp Thr Phe Gly Glu Gly Thr Lys Leu Glu Ile Lys Arg 
        115                 120                 125             


Ala Asp Ala Ala Pro Thr Val Ser Ile Phe Pro Pro Ser Ser Glu Gln 
    130                 135                 140                 


Leu Thr Ser Gly Gly Ala Ser Val Val Cys Phe Leu Asn Asn Phe Tyr 
145                 150                 155                 160 


Pro Lys Asp Ile Asn Val Lys Trp Lys Ile Asp Gly Ser Glu Arg Gln 
                165                 170                 175     


Asn Gly Val Leu Asn Ser Trp Thr Asp Gln Asp Ser Lys Asp Ser Thr 
            180                 185                 190         


Tyr Ser Met Ser Ser Thr Leu Thr Leu Thr Lys Asp Glu Tyr Glu Arg 
        195                 200                 205             


His Asn Ser Tyr Thr Cys Glu Ala Thr His Lys Thr Ser Thr Ser Pro 
    210                 215                 220                 


Ile Val Lys Ser Phe Asn Arg Asn Glu Cys 
225                 230                 


<210>  9
<211>  471
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence of the heavy chain of IgG2a anti-CD33 
       antibody 5D12

<400>  9

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Val Val 
            20                  25                  30          


Lys Pro Gly Ala Ser Val Lys Ile Ser Cys Arg Ala Ser Gly Tyr Ala 
        35                  40                  45              


Phe Ser Asn Tyr Trp Met Asn Trp Val Lys Gln Arg Pro Gly Lys Gly 
    50                  55                  60                  


Leu Glu Trp Ile Gly Gln Ile Tyr Pro Gly Asn Phe Asn Thr Asp Tyr 
65                  70                  75                  80  


Asn Gly Gln Phe Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser 
                85                  90                  95      


Asn Thr Ala Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala 
            100                 105                 110         


Val Tyr Phe Cys Ala Arg Phe Phe Asp Phe Gly Ala Tyr Phe Thr Leu 
        115                 120                 125             


Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Ala Lys Thr 
    130                 135                 140                 


Thr Ala Pro Ser Val Tyr Pro Leu Ala Pro Val Cys Gly Asp Thr Thr 
145                 150                 155                 160 


Gly Ser Ser Val Thr Leu Gly Cys Leu Val Lys Gly Tyr Phe Pro Glu 
                165                 170                 175     


Pro Val Thr Leu Thr Trp Asn Ser Gly Ser Leu Ser Ser Gly Val His 
            180                 185                 190         


Thr Phe Pro Ala Val Leu Gln Ser Asp Leu Tyr Thr Leu Ser Ser Ser 
        195                 200                 205             


Val Thr Val Thr Ser Ser Thr Trp Pro Ser Gln Ser Ile Thr Cys Asn 
    210                 215                 220                 


Val Ala His Pro Ala Ser Ser Thr Lys Val Asp Lys Lys Ile Glu Pro 
225                 230                 235                 240 


Arg Gly Pro Thr Ile Lys Pro Cys Pro Pro Cys Lys Cys Pro Ala Pro 
                245                 250                 255     


Asn Leu Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro Lys Ile Lys 
            260                 265                 270         


Asp Val Leu Met Ile Ser Leu Ser Pro Ile Val Thr Cys Val Val Val 
        275                 280                 285             


Asp Val Ser Glu Asp Asp Pro Asp Val Gln Ile Ser Trp Phe Val Asn 
    290                 295                 300                 


Asn Val Glu Val His Thr Ala Gln Thr Gln Thr His Arg Glu Asp Tyr 
305                 310                 315                 320 


Asn Ser Thr Leu Arg Val Val Ser Ala Leu Pro Ile Gln His Gln Asp 
                325                 330                 335     


Trp Met Ser Gly Lys Glu Phe Lys Cys Lys Val Asn Asn Lys Asp Leu 
            340                 345                 350         


Pro Ala Pro Ile Glu Arg Thr Ile Ser Lys Pro Lys Gly Ser Val Arg 
        355                 360                 365             


Ala Pro Gln Val Tyr Val Leu Pro Pro Pro Glu Glu Glu Met Thr Lys 
    370                 375                 380                 


Lys Gln Val Thr Leu Thr Cys Met Val Thr Asp Phe Met Pro Glu Asp 
385                 390                 395                 400 


Ile Tyr Val Glu Trp Thr Asn Asn Gly Lys Thr Glu Leu Asn Tyr Lys 
                405                 410                 415     


Asn Thr Glu Pro Val Leu Asp Ser Asp Gly Ser Tyr Phe Met Tyr Ser 
            420                 425                 430         


Lys Leu Arg Val Glu Lys Lys Asn Trp Val Glu Arg Asn Ser Tyr Ser 
        435                 440                 445             


Cys Ser Val Val His Glu Gly Leu His Asn His His Thr Thr Lys Ser 
    450                 455                 460                 


Phe Ser Arg Thr Pro Gly Lys 
465                 470     


<210>  10
<211>  240
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence of the light chain of IgG2a anti-CD33 
       antibody 8F5

<400>  10

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ile Val Met Ser Gln Ser Pro Ser Ser Leu Pro 
            20                  25                  30          


Val Ser Val Gly Glu Lys Val Thr Leu Ser Cys Lys Ser Ser Gln Ser 
        35                  40                  45              


Leu Leu Tyr Ser Arg Asn Gln Tyr Asn Phe Leu Ala Trp Tyr Gln Gln 
    50                  55                  60                  


Arg Pro Gly Gln Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg 
65                  70                  75                  80  


Glu Ser Gly Val Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp 
                85                  90                  95      


Phe Thr Leu Thr Ile Ser Ser Val Lys Ala Glu Asp Leu Ala Val Tyr 
            100                 105                 110         


Tyr Cys Gln Gln Tyr Tyr Ser Tyr Pro Tyr Thr Phe Gly Gly Gly Thr 
        115                 120                 125             


Lys Leu Glu Ile Lys Arg Ala Asp Ala Ala Pro Thr Val Ser Ile Phe 
    130                 135                 140                 


Pro Pro Ser Ser Glu Gln Leu Thr Ser Gly Gly Ala Ser Val Val Cys 
145                 150                 155                 160 


Phe Leu Asn Asn Phe Tyr Pro Lys Asp Ile Asn Val Lys Trp Lys Ile 
                165                 170                 175     


Asp Gly Ser Glu Arg Gln Asn Gly Val Leu Asn Ser Trp Thr Asp Gln 
            180                 185                 190         


Asp Ser Lys Asp Ser Thr Tyr Ser Met Ser Ser Thr Leu Thr Leu Thr 
        195                 200                 205             


Lys Asp Glu Tyr Glu Arg His Asn Ser Tyr Thr Cys Glu Ala Thr His 
    210                 215                 220                 


Lys Thr Ser Thr Ser Pro Ile Val Lys Ser Phe Asn Arg Asn Glu Cys 
225                 230                 235                 240 


<210>  11
<211>  469
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence of the heavy chain of IgG2a anti-CD33 
       antibody 8F5

<400>  11

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Glu Val Lys Leu Val Glu Ser Gly Gly Gly Leu Val 
            20                  25                  30          


Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr 
        35                  40                  45              


Phe Ser Asp Phe Tyr Met Tyr Trp Val Arg Gln Thr Pro Glu Lys Arg 
    50                  55                  60                  


Leu Glu Trp Val Ala Phe Ile Ser Asn Ala Gly Val Thr Thr Tyr Tyr 
65                  70                  75                  80  


Pro Asp Thr Val Glu Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys 
                85                  90                  95      


Asn Thr Leu Tyr Leu Gln Met Ser Arg Leu Met Ser Glu Asp Thr Ala 
            100                 105                 110         


Met Tyr Tyr Cys Thr Lys Ser Asp Tyr Asp Gly Ala Trp Phe Pro Tyr 
        115                 120                 125             


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ala Ala Lys Thr Thr Ala 
    130                 135                 140                 


Pro Ser Val Tyr Pro Leu Ala Pro Val Cys Gly Asp Thr Thr Gly Ser 
145                 150                 155                 160 


Ser Val Thr Leu Gly Cys Leu Val Lys Gly Tyr Phe Pro Glu Pro Val 
                165                 170                 175     


Thr Leu Thr Trp Asn Ser Gly Ser Leu Ser Ser Gly Val His Thr Phe 
            180                 185                 190         


Pro Ala Val Leu Gln Ser Asp Leu Tyr Thr Leu Ser Ser Ser Val Thr 
        195                 200                 205             


Val Thr Ser Ser Thr Trp Pro Ser Gln Ser Ile Thr Cys Asn Val Ala 
    210                 215                 220                 


His Pro Ala Ser Ser Thr Lys Val Asp Lys Lys Ile Glu Pro Arg Gly 
225                 230                 235                 240 


Pro Thr Ile Lys Pro Cys Pro Pro Cys Lys Cys Pro Ala Pro Asn Leu 
                245                 250                 255     


Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro Lys Ile Lys Asp Val 
            260                 265                 270         


Leu Met Ile Ser Leu Ser Pro Ile Val Thr Cys Val Val Val Asp Val 
        275                 280                 285             


Ser Glu Asp Asp Pro Asp Val Gln Ile Ser Trp Phe Val Asn Asn Val 
    290                 295                 300                 


Glu Val His Thr Ala Gln Thr Gln Thr His Arg Glu Asp Tyr Asn Ser 
305                 310                 315                 320 


Thr Leu Arg Val Val Ser Ala Leu Pro Ile Gln His Gln Asp Trp Met 
                325                 330                 335     


Ser Gly Lys Glu Phe Lys Cys Lys Val Asn Asn Lys Asp Leu Pro Ala 
            340                 345                 350         


Pro Ile Glu Arg Thr Ile Ser Lys Pro Lys Gly Ser Val Arg Ala Pro 
        355                 360                 365             


Gln Val Tyr Val Leu Pro Pro Pro Glu Glu Glu Met Thr Lys Lys Gln 
    370                 375                 380                 


Val Thr Leu Thr Cys Met Val Thr Asp Phe Met Pro Glu Asp Ile Tyr 
385                 390                 395                 400 


Val Glu Trp Thr Asn Asn Gly Lys Thr Glu Leu Asn Tyr Lys Asn Thr 
                405                 410                 415     


Glu Pro Val Leu Asp Ser Asp Gly Ser Tyr Phe Met Tyr Ser Lys Leu 
            420                 425                 430         


Arg Val Glu Lys Lys Asn Trp Val Glu Arg Asn Ser Tyr Ser Cys Ser 
        435                 440                 445             


Val Val His Glu Gly Leu His Asn His His Thr Thr Lys Ser Phe Ser 
    450                 455                 460                 


Arg Thr Pro Gly Lys 
465                 


<210>  12
<211>  239
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence of the light chain of IgG2b anti-CD33 
       antibody 12B12

<400>  12

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ile Val Met Thr Gln Ala Ala Phe Ser Asn Pro 
            20                  25                  30          


Val Thr Leu Gly Thr Ser Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser 
        35                  40                  45              


Leu Leu His Ser Asn Gly Ile Thr Tyr Leu Tyr Trp Tyr Leu Gln Lys 
    50                  55                  60                  


Pro Gly Gln Ser Pro Gln Leu Leu Ile Tyr Gln Met Ser Asn Leu Ala 
65                  70                  75                  80  


Ser Gly Val Pro Asp Arg Phe Ser Ser Ser Gly Ser Gly Thr Asp Phe 
                85                  90                  95      


Thr Leu Arg Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr 
            100                 105                 110         


Cys Ala Gln Asn Leu Glu Leu Pro Pro Thr Phe Gly Gly Gly Thr Lys 
        115                 120                 125             


Leu Glu Ile Lys Arg Ala Asp Ala Ala Pro Thr Val Ser Ile Phe Pro 
    130                 135                 140                 


Pro Ser Ser Glu Gln Leu Thr Ser Gly Gly Ala Ser Val Val Cys Phe 
145                 150                 155                 160 


Leu Asn Asn Phe Tyr Pro Lys Asp Ile Asn Val Lys Trp Lys Ile Asp 
                165                 170                 175     


Gly Ser Glu Arg Gln Asn Gly Val Leu Asn Ser Trp Thr Asp Gln Asp 
            180                 185                 190         


Ser Lys Asp Ser Thr Tyr Ser Met Ser Ser Thr Leu Thr Leu Thr Lys 
        195                 200                 205             


Asp Glu Tyr Glu Arg His Asn Ser Tyr Thr Cys Glu Ala Thr His Lys 
    210                 215                 220                 


Thr Ser Thr Ser Pro Ile Val Lys Ser Phe Asn Arg Asn Glu Cys 
225                 230                 235                 


<210>  13
<211>  473
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence of the heavy chain of IgG2b anti-CD33 
       antibody 12B12

<400>  13

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Glu Val Gln Leu Gln Gln Ser Gly Thr Val Leu Ala 
            20                  25                  30          


Arg Pro Gly Ala Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr 
        35                  40                  45              


Phe Thr Thr Tyr Trp Met His Trp Ile Lys Gln Ser Pro Gly Gln Gly 
    50                  55                  60                  


Leu Glu Trp Ile Gly Ala Ile Tyr Pro Gly Asn Ser Asp Thr Ser Tyr 
65                  70                  75                  80  


Asn Gln Lys Phe Lys Gly Lys Ala Lys Leu Thr Ala Val Thr Ser Ala 
                85                  90                  95      


Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Thr Asn Glu Asp Ser Ala 
            100                 105                 110         


Val Tyr Tyr Cys Glu Ile Tyr Asp Gly Tyr His Phe Ile Tyr Trp Gly 
        115                 120                 125             


Gln Gly Thr Thr Leu Thr Val Ser Ser Ala Lys Thr Thr Pro Pro Ser 
    130                 135                 140                 


Val Tyr Pro Leu Ala Pro Gly Cys Gly Asp Thr Thr Gly Ser Ser Val 
145                 150                 155                 160 


Thr Leu Gly Cys Leu Val Lys Gly Tyr Phe Pro Glu Ser Val Thr Val 
                165                 170                 175     


Thr Trp Asn Ser Gly Ser Leu Ser Ser Ser Val His Thr Phe Pro Ala 
            180                 185                 190         


Leu Leu Gln Ser Gly Leu Tyr Thr Met Ser Ser Ser Val Thr Val Pro 
        195                 200                 205             


Ser Ser Thr Trp Pro Ser Gln Thr Val Thr Cys Ser Val Ala His Pro 
    210                 215                 220                 


Ala Ser Ser Thr Thr Val Asp Lys Lys Leu Glu Pro Ser Gly Pro Ile 
225                 230                 235                 240 


Ser Thr Ile Asn Pro Cys Pro Pro Cys Lys Glu Cys His Lys Cys Pro 
                245                 250                 255     


Ala Pro Asn Leu Glu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro Asn 
            260                 265                 270         


Ile Lys Asp Val Leu Met Ile Ser Leu Thr Pro Lys Val Thr Cys Val 
        275                 280                 285             


Val Val Asp Val Ser Glu Asp Asp Pro Asp Val Gln Ile Ser Trp Phe 
    290                 295                 300                 


Val Asn Asn Val Glu Val His Thr Ala Gln Thr Gln Thr His Arg Glu 
305                 310                 315                 320 


Asp Tyr Asn Ser Thr Ile Arg Val Val Ser Thr Leu Pro Ile Gln His 
                325                 330                 335     


Gln Asp Trp Met Ser Gly Lys Glu Phe Lys Cys Lys Val Asn Asn Lys 
            340                 345                 350         


Asp Leu Pro Ser Pro Ile Glu Arg Thr Ile Ser Lys Ile Lys Gly Leu 
        355                 360                 365             


Val Arg Ala Pro Gln Val Tyr Ile Leu Pro Pro Pro Ala Glu Gln Leu 
    370                 375                 380                 


Ser Arg Lys Asp Val Ser Leu Thr Cys Leu Val Val Gly Phe Asn Pro 
385                 390                 395                 400 


Gly Asp Ile Ser Val Glu Trp Thr Ser Asn Gly His Thr Glu Glu Asn 
                405                 410                 415     


Tyr Lys Asp Thr Ala Pro Val Leu Asp Ser Asp Gly Ser Tyr Phe Ile 
            420                 425                 430         


Tyr Ser Lys Leu Asn Met Lys Thr Ser Lys Trp Glu Lys Thr Asp Ser 
        435                 440                 445             


Phe Ser Cys Asn Val Arg His Glu Gly Leu Lys Asn Tyr Tyr Leu Lys 
    450                 455                 460                 


Lys Thr Ile Ser Arg Ser Pro Gly Lys 
465                 470             


<210>  14
<211>  238
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence of the light chain of IgG1 anti-CD33 antibody
       4H10

<400>  14

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Val Val Met Thr Gln Thr Pro Leu Thr Leu Ser 
            20                  25                  30          


Val Thr Ile Gly Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser 
        35                  40                  45              


Leu Leu Tyr Ser Asn Gly Lys Thr Tyr Leu His Trp Phe Leu Gln Arg 
    50                  55                  60                  


Pro Gly Gln Ser Pro Lys Arg Leu Ile Tyr Leu Val Ser Lys Leu Asp 
65                  70                  75                  80  


Ser Gly Val Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe 
                85                  90                  95      


Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr 
            100                 105                 110         


Cys Val Gln Gly Thr His Phe Pro Arg Thr Phe Gly Gly Gly Thr Lys 
        115                 120                 125             


Leu Glu Ile Lys Ala Asp Ala Ala Pro Thr Val Ser Ile Phe Pro Pro 
    130                 135                 140                 


Ser Ser Glu Gln Leu Thr Ser Gly Gly Ala Ser Val Val Cys Phe Leu 
145                 150                 155                 160 


Asn Asn Phe Tyr Pro Lys Asp Ile Asn Val Lys Trp Lys Ile Asp Gly 
                165                 170                 175     


Ser Glu Arg Gln Asn Gly Val Leu Asn Ser Trp Thr Asp Gln Asp Ser 
            180                 185                 190         


Lys Asp Ser Thr Tyr Ser Met Ser Ser Thr Leu Thr Leu Thr Lys Asp 
        195                 200                 205             


Glu Tyr Glu Arg His Asn Ser Tyr Thr Cys Glu Ala Thr His Lys Thr 
    210                 215                 220                 


Ser Thr Ser Pro Ile Val Lys Ser Phe Asn Arg Asn Glu Cys 
225                 230                 235             


<210>  15
<211>  464
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence of the heavy chain of IgG1 anti-CD33 antibody
       4H10

<400>  15

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val 
            20                  25                  30          


Arg Pro Gly Thr Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ala 
        35                  40                  45              


Phe Thr Asn Tyr Leu Ile Glu Trp Val Lys Gln Arg Pro Gly Gln Gly 
    50                  55                  60                  


Leu Glu Trp Ile Gly Val Ile His Pro Gly Asn Asn Ser Thr Ser Tyr 
65                  70                  75                  80  


Asn Ala Lys Phe Arg Gly Lys Ala Thr Leu Thr Ala Asp Arg Ser Ser 
                85                  90                  95      


Ser Thr Ala Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala 
            100                 105                 110         


Val Tyr Phe Cys Ala Arg Tyr Gly Tyr Asp Glu Arg Asn Ala Met Asp 
        115                 120                 125             


Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Ala Lys Thr Thr 
    130                 135                 140                 


Pro Pro Ser Val Tyr Pro Leu Ala Pro Gly Ser Ala Ala Gln Thr Asn 
145                 150                 155                 160 


Ser Met Val Thr Leu Gly Cys Leu Val Lys Gly Tyr Phe Pro Glu Pro 
                165                 170                 175     


Val Thr Val Thr Trp Asn Ser Gly Ser Leu Ser Ser Gly Val His Thr 
            180                 185                 190         


Phe Pro Ala Val Leu Gln Ser Asp Leu Tyr Thr Leu Ser Ser Ser Val 
        195                 200                 205             


Thr Val Pro Ser Ser Pro Arg Pro Ser Glu Thr Val Thr Cys Asn Val 
    210                 215                 220                 


Ala His Pro Ala Ser Ser Thr Lys Val Asp Lys Lys Ile Val Pro Arg 
225                 230                 235                 240 


Asp Cys Gly Cys Lys Pro Cys Ile Cys Thr Val Pro Glu Val Ser Ser 
                245                 250                 255     


Val Phe Ile Phe Pro Pro Lys Pro Lys Asp Val Leu Thr Ile Thr Leu 
            260                 265                 270         


Thr Pro Lys Val Thr Cys Val Val Val Asp Ile Ser Lys Asp Asp Pro 
        275                 280                 285             


Glu Val Gln Phe Ser Trp Phe Val Asp Asp Val Glu Val His Thr Ala 
    290                 295                 300                 


Gln Thr Gln Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg Ser Val 
305                 310                 315                 320 


Ser Glu Leu Pro Ile Met His Gln Asp Trp Leu Asn Gly Lys Glu Phe 
                325                 330                 335     


Lys Cys Arg Val Asn Ser Ala Ala Phe Pro Ala Pro Ile Glu Lys Thr 
            340                 345                 350         


Ile Ser Lys Thr Lys Gly Arg Pro Lys Ala Pro Gln Val Tyr Thr Ile 
        355                 360                 365             


Pro Pro Pro Lys Glu Gln Met Ala Lys Asp Lys Val Ser Leu Thr Cys 
    370                 375                 380                 


Met Ile Thr Asp Phe Phe Pro Glu Asp Ile Thr Val Glu Trp Gln Trp 
385                 390                 395                 400 


Asn Gly Gln Pro Ala Glu Asn Tyr Lys Asn Thr Gln Pro Ile Met Asn 
                405                 410                 415     


Thr Asn Gly Ser Tyr Phe Val Tyr Ser Lys Leu Asn Val Gln Lys Ser 
            420                 425                 430         


Asn Trp Glu Ala Gly Asn Thr Phe Thr Cys Ser Val Leu His Glu Gly 
        435                 440                 445             


Leu His Asn His His Thr Glu Lys Ser Leu Ser His Ser Pro Gly Lys 
    450                 455                 460                 


<210>  16
<211>  239
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence of the light chain of IgG1 anti-CD33 antibody
       11D5

<400>  16

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ile Val Met Thr Gln Ala Ala Phe Ser Asn Pro 
            20                  25                  30          


Val Thr Leu Gly Thr Ser Ala Ser Ile Ser Cys Arg Ser Asn Lys Ser 
        35                  40                  45              


Leu Leu His Ser Asn Gly Ile Thr Tyr Leu Tyr Trp Tyr Leu Gln Lys 
    50                  55                  60                  


Pro Gly Gln Ser Pro Gln Leu Leu Ile Tyr Gln Met Ser Asn Leu Ala 
65                  70                  75                  80  


Ser Gly Val Pro Asp Arg Phe Ser Ser Ser Gly Ser Gly Thr Asp Phe 
                85                  90                  95      


Thr Leu Arg Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr 
            100                 105                 110         


Cys Ala Gln Asn Leu Glu Leu Pro Pro Thr Phe Gly Gly Gly Thr Lys 
        115                 120                 125             


Leu Glu Ile Lys Arg Ala Asp Ala Ala Pro Thr Val Ser Ile Phe Pro 
    130                 135                 140                 


Pro Ser Ser Glu Gln Leu Thr Ser Gly Gly Ala Ser Val Val Cys Phe 
145                 150                 155                 160 


Leu Asn Asn Phe Tyr Pro Lys Asp Ile Asn Val Lys Trp Lys Ile Asp 
                165                 170                 175     


Gly Ser Glu Arg Gln Asn Gly Val Leu Asn Ser Trp Thr Asp Gln Asp 
            180                 185                 190         


Ser Lys Asp Ser Thr Tyr Ser Met Ser Ser Thr Leu Thr Leu Thr Lys 
        195                 200                 205             


Asp Glu Tyr Glu Arg His Asn Ser Tyr Thr Cys Glu Ala Thr His Lys 
    210                 215                 220                 


Thr Ser Thr Ser Pro Ile Val Lys Ser Phe Asn Arg Asn Glu Cys 
225                 230                 235                 


<210>  17
<211>  461
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence of the heavy chain of IgG1 anti-CD33 antibody
       11D5

<400>  17

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Glu Val Gln Phe Gln Gln Ser Glu Thr Val Leu Ala 
            20                  25                  30          


Arg Pro Gly Thr Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr 
        35                  40                  45              


Phe Thr Ser Tyr Trp Met His Trp Leu Lys Gln Arg Pro Gly Gln Gly 
    50                  55                  60                  


Leu Glu Trp Ile Gly Ala Ile Tyr Cys Gly Asn Ser Asp Thr Ser Tyr 
65                  70                  75                  80  


Asn Gln Lys Phe Lys Gly Lys Ala Lys Leu Thr Ala Val Thr Ser Ala 
                85                  90                  95      


Thr Thr Ala Tyr Met Glu Leu Ser Ser Leu Thr Asn Glu Asp Ser Ala 
            100                 105                 110         


Val Tyr Tyr Cys Lys Ile Tyr Asp Gly Tyr His Phe Asp Tyr Trp Gly 
        115                 120                 125             


Gln Gly Thr Thr Leu Thr Val Ser Ser Ala Lys Thr Thr Pro Pro Ser 
    130                 135                 140                 


Val Tyr Pro Leu Ala Pro Gly Ser Ala Ala Gln Thr Asn Ser Met Val 
145                 150                 155                 160 


Thr Leu Gly Cys Leu Val Lys Gly Tyr Phe Pro Glu Pro Val Thr Val 
                165                 170                 175     


Thr Trp Asn Ser Gly Ser Leu Ser Ser Gly Val His Thr Phe Pro Ala 
            180                 185                 190         


Val Leu Gln Ser Asp Leu Tyr Thr Leu Ser Ser Ser Val Thr Val Pro 
        195                 200                 205             


Ser Ser Pro Arg Pro Ser Glu Thr Val Thr Cys Asn Val Ala His Pro 
    210                 215                 220                 


Ala Ser Ser Thr Lys Val Asp Lys Lys Ile Val Pro Arg Asp Cys Gly 
225                 230                 235                 240 


Cys Lys Pro Cys Ile Cys Thr Val Pro Glu Val Ser Ser Val Phe Ile 
                245                 250                 255     


Phe Pro Pro Lys Pro Lys Asp Val Leu Thr Ile Thr Leu Thr Pro Lys 
            260                 265                 270         


Val Thr Cys Val Val Val Asp Ile Ser Lys Asp Asp Pro Glu Val Gln 
        275                 280                 285             


Phe Ser Trp Phe Val Asp Asp Val Glu Val His Thr Ala Gln Thr Gln 
    290                 295                 300                 


Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg Ser Val Ser Glu Leu 
305                 310                 315                 320 


Pro Ile Met His Gln Asp Trp Leu Asn Gly Lys Glu Phe Lys Cys Arg 
                325                 330                 335     


Val Asn Ser Ala Ala Phe Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
            340                 345                 350         


Thr Lys Gly Arg Pro Lys Ala Pro Gln Val Tyr Thr Ile Pro Pro Pro 
        355                 360                 365             


Lys Glu Gln Met Ala Lys Asp Lys Val Ser Leu Thr Cys Met Ile Thr 
    370                 375                 380                 


Asp Phe Phe Pro Glu Asp Ile Thr Val Glu Trp Gln Trp Asn Gly Gln 
385                 390                 395                 400 


Pro Ala Glu Asn Tyr Lys Asn Thr Gln Pro Ile Met Asn Thr Asn Gly 
                405                 410                 415     


Ser Tyr Phe Val Tyr Ser Lys Leu Asn Val Gln Lys Ser Asn Trp Glu 
            420                 425                 430         


Ala Gly Asn Thr Phe Thr Cys Ser Val Leu His Glu Gly Leu His Asn 
        435                 440                 445             


His His Thr Glu Lys Ser Leu Ser His Ser Pro Gly Lys 
    450                 455                 460     


<210>  18
<211>  227
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence of the light chain of IgG1 anti-CD33 antibody
       13E11

<400>  18

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ile Val Leu Thr Gln Ser Pro Val Ser Leu Ala 
            20                  25                  30          


Val Ser Leu Gly Gln Arg Ala Thr Ile Ser Cys Lys Ala Ser His Gly 
        35                  40                  45              


Val Glu Tyr Ala Gly Ala His Tyr Met Asn Trp Tyr Gln Gln Lys Pro 
    50                  55                  60                  


Gly Gln Pro Pro Lys Leu Leu Ile Tyr Ala Ala Ser Asn Leu Gly Ser 
65                  70                  75                  80  


Gly Thr Asp Phe Thr Leu Asn Ile His Pro Val Glu Glu Glu Asp Ser 
                85                  90                  95      


Ala Thr Tyr Tyr Cys Gln Gln Ser Asn Glu Asp Pro Arg Thr Phe Gly 
            100                 105                 110         


Gly Gly Thr Lys Leu Glu Ile Lys Arg Ala Asp Ala Ala Pro Thr Val 
        115                 120                 125             


Ser Ile Phe Pro Pro Ser Ser Glu Gln Leu Thr Ser Gly Gly Ala Ser 
    130                 135                 140                 


Val Val Cys Phe Leu Asn Asn Phe Tyr Pro Lys Asp Ile Asn Val Lys 
145                 150                 155                 160 


Trp Lys Ile Asp Gly Ser Glu Arg Gln Asn Gly Val Leu Asn Ser Trp 
                165                 170                 175     


Thr Asp Gln Asp Ser Lys Asp Ser Thr Tyr Ser Met Ser Ser Thr Leu 
            180                 185                 190         


Thr Leu Thr Lys Asp Glu Tyr Glu Arg His Asn Ser Tyr Thr Cys Glu 
        195                 200                 205             


Ala Thr His Lys Thr Ser Thr Ser Pro Ile Val Lys Ser Phe Asn Arg 
    210                 215                 220                 


Asn Glu Cys 
225         


<210>  19
<211>  460
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence of the heavy chain of IgG1 anti-CD33 antibody
       13E11

<400>  19

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Lys Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val 
            20                  25                  30          


Lys Pro Gly Ala Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr 
        35                  40                  45              


Phe Thr Asp Tyr Thr Leu His Trp Leu Lys Gln Arg Ser Gly Gln Gly 
    50                  55                  60                  


Leu Glu Trp Ile Gly Trp Phe Tyr Pro Thr Ser Gly Ser Ile Asn Tyr 
65                  70                  75                  80  


Asn Glu Arg Phe Lys Asp Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser 
                85                  90                  95      


Ser Thr Val Tyr Met Glu Leu Ser Arg Leu Thr Ser Val Asp Ser Ala 
            100                 105                 110         


Val Tyr Phe Cys Ala Arg His Lys Phe Gly Phe Asp Tyr Trp Gly Gln 
        115                 120                 125             


Gly Thr Thr Leu Thr Val Ser Ser Ala Lys Thr Thr Pro Pro Ser Val 
    130                 135                 140                 


Tyr Pro Leu Ala Pro Gly Ser Ala Ala Gln Thr Asn Ser Met Val Thr 
145                 150                 155                 160 


Leu Gly Cys Leu Val Lys Gly Tyr Phe Pro Glu Pro Val Thr Val Thr 
                165                 170                 175     


Trp Asn Ser Gly Ser Leu Ser Ser Gly Val His Thr Phe Pro Ala Val 
            180                 185                 190         


Leu Gln Ser Asp Leu Tyr Thr Leu Ser Ser Ser Val Thr Val Pro Ser 
        195                 200                 205             


Ser Pro Arg Pro Ser Glu Thr Val Thr Cys Asn Val Ala His Pro Ala 
    210                 215                 220                 


Ser Ser Thr Lys Val Asp Lys Lys Ile Val Pro Arg Asp Cys Gly Cys 
225                 230                 235                 240 


Lys Pro Cys Ile Cys Thr Val Pro Glu Val Ser Ser Val Phe Ile Phe 
                245                 250                 255     


Pro Pro Lys Pro Lys Asp Val Leu Thr Ile Thr Leu Thr Pro Lys Val 
            260                 265                 270         


Thr Cys Val Val Val Asp Ile Ser Lys Asp Asp Pro Glu Val Gln Phe 
        275                 280                 285             


Ser Trp Phe Val Asp Asp Val Glu Val His Thr Ala Gln Thr Gln Pro 
    290                 295                 300                 


Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg Ser Val Ser Glu Leu Pro 
305                 310                 315                 320 


Ile Met His Gln Asp Trp Leu Asn Gly Lys Glu Phe Lys Cys Arg Val 
                325                 330                 335     


Asn Ser Ala Ala Phe Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr 
            340                 345                 350         


Lys Gly Arg Pro Lys Ala Pro Gln Val Tyr Thr Ile Pro Pro Pro Lys 
        355                 360                 365             


Glu Gln Met Ala Lys Asp Lys Val Ser Leu Thr Cys Met Ile Thr Asp 
    370                 375                 380                 


Phe Phe Pro Glu Asp Ile Thr Val Glu Trp Gln Trp Asn Gly Gln Pro 
385                 390                 395                 400 


Ala Glu Asn Tyr Lys Asn Thr Gln Pro Ile Met Asn Thr Asn Gly Ser 
                405                 410                 415     


Tyr Phe Val Tyr Ser Lys Leu Asn Val Gln Lys Ser Asn Trp Glu Ala 
            420                 425                 430         


Gly Asn Thr Phe Thr Cys Ser Val Leu His Glu Gly Leu His Asn His 
        435                 440                 445             


His Thr Glu Lys Ser Leu Ser His Ser Pro Gly Lys 
    450                 455                 460 


<210>  20
<211>  234
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence of the light chain of IgG1 anti-CD33 antibody
       5E10.7

<400>  20

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ile Lys Met Thr Gln Ser Pro Ser Ser Ile Tyr 
            20                  25                  30          


Ala Ser Leu Gly Glu Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp 
        35                  40                  45              


Ile Lys Ser Tyr Leu Ser Trp Tyr Gln Gln Lys Pro Arg Lys Ser Pro 
    50                  55                  60                  


Lys Thr Leu Ile Tyr Tyr Ala Thr Thr Leu Ala Asp Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Gly Ser Gly Gln Asp Phe Ser Leu Thr Ile Ser 
                85                  90                  95      


Ser Leu Glu Ser Asp Asp Thr Ala Thr Tyr Tyr Cys Leu His His Ser 
            100                 105                 110         


Glu Ser Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg 
        115                 120                 125             


Ala Asp Ala Ala Pro Thr Val Ser Ile Phe Pro Pro Ser Ser Glu Gln 
    130                 135                 140                 


Leu Thr Ser Gly Gly Ala Ser Val Val Cys Phe Leu Asn Asn Phe Tyr 
145                 150                 155                 160 


Pro Lys Asp Ile Asn Val Lys Trp Lys Ile Asp Gly Ser Glu Arg Gln 
                165                 170                 175     


Asn Gly Val Leu Asn Ser Trp Thr Asp Gln Asp Ser Lys Asp Ser Thr 
            180                 185                 190         


Tyr Ser Met Ser Ser Thr Leu Thr Leu Thr Lys Asp Glu Tyr Glu Arg 
        195                 200                 205             


His Asn Ser Tyr Thr Cys Glu Ala Thr His Lys Thr Ser Thr Ser Pro 
    210                 215                 220                 


Ile Val Lys Ser Phe Asn Arg Asn Glu Cys 
225                 230                 


<210>  21
<211>  462
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence of the heavy chain of IgG1 anti-CD33 antibody
       5E10.7

<400>  21

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Phe Val 
            20                  25                  30          


Lys Pro Gly Ala Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr 
        35                  40                  45              


Phe Thr Ser Tyr Trp Met Gln Trp Val Lys Gln Arg Pro Gly Gln Gly 
    50                  55                  60                  


Leu Glu Trp Ile Gly Glu Ile Asp Ser Ser Asp Ser Tyr Thr Asn Tyr 
65                  70                  75                  80  


Asn Gln Lys Phe Lys Gly Met Ala Thr Leu Thr Val Asp Arg Ser Ser 
                85                  90                  95      


Ser Thr Ala Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala 
            100                 105                 110         


Val Tyr Tyr Cys Ala Arg Ser Arg Pro Tyr Asp Trp Phe Pro Tyr Trp 
        115                 120                 125             


Gly Gln Gly Thr Leu Val Thr Val Ser Thr Ala Lys Thr Thr Pro Pro 
    130                 135                 140                 


Ser Val Tyr Pro Leu Ala Pro Gly Ser Ala Ala Gln Thr Asn Ser Met 
145                 150                 155                 160 


Val Thr Leu Gly Cys Leu Val Lys Gly Tyr Phe Pro Glu Pro Val Thr 
                165                 170                 175     


Val Thr Trp Asn Ser Gly Ser Leu Ser Ser Gly Val His Thr Phe Pro 
            180                 185                 190         


Ala Val Leu Gln Ser Asp Leu Tyr Thr Leu Ser Ser Ser Val Thr Val 
        195                 200                 205             


Pro Ser Ser Pro Arg Pro Ser Glu Thr Val Thr Cys Asn Val Ala His 
    210                 215                 220                 


Pro Ala Ser Ser Thr Lys Val Asp Lys Lys Ile Val Pro Arg Asp Cys 
225                 230                 235                 240 


Gly Cys Lys Pro Cys Ile Cys Thr Val Pro Glu Val Ser Ser Val Phe 
                245                 250                 255     


Ile Phe Pro Pro Lys Pro Lys Asp Val Leu Thr Ile Thr Leu Thr Pro 
            260                 265                 270         


Lys Val Thr Cys Val Val Val Asp Ile Ser Lys Asp Asp Pro Glu Val 
        275                 280                 285             


Gln Phe Ser Trp Phe Val Asp Asp Val Glu Val His Thr Ala Gln Thr 
    290                 295                 300                 


Gln Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg Ser Val Ser Glu 
305                 310                 315                 320 


Leu Pro Ile Met His Gln Asp Trp Leu Asn Gly Lys Glu Phe Lys Cys 
                325                 330                 335     


Arg Val Asn Ser Ala Ala Phe Pro Ala Pro Ile Glu Lys Thr Ile Ser 
            340                 345                 350         


Lys Thr Lys Gly Arg Pro Lys Ala Pro Gln Val Tyr Thr Ile Pro Pro 
        355                 360                 365             


Pro Lys Glu Gln Met Ala Lys Asp Lys Val Ser Leu Thr Cys Met Ile 
    370                 375                 380                 


Thr Asp Phe Phe Pro Glu Asp Ile Thr Val Glu Trp Gln Trp Asn Gly 
385                 390                 395                 400 


Gln Pro Ala Glu Asn Tyr Lys Asn Thr Gln Pro Ile Met Asn Thr Asn 
                405                 410                 415     


Gly Ser Tyr Phe Val Tyr Ser Lys Leu Asn Val Gln Lys Ser Asn Trp 
            420                 425                 430         


Glu Ala Gly Asn Thr Phe Thr Cys Ser Val Leu His Glu Gly Leu His 
        435                 440                 445             


Asn His His Thr Glu Lys Ser Leu Ser His Ser Pro Gly Lys 
    450                 455                 460         


<210>  22
<211>  234
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence of the light chain of IgG1 anti-CD33 antibody
       11D11

<400>  22

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser 
            20                  25                  30          


Ala Ser Leu Gly Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp 
        35                  40                  45              


Ile Ser Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val 
    50                  55                  60                  


Lys Leu Leu Ile Tyr Tyr Thr Ser Arg Leu His Ser Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser 
                85                  90                  95      


Asn Leu Glu Gln Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Ser 
            100                 105                 110         


Thr Leu Pro Pro Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg 
        115                 120                 125             


Ala Asp Ala Ala Pro Thr Val Ser Ile Phe Pro Pro Ser Ser Glu Gln 
    130                 135                 140                 


Leu Thr Ser Gly Gly Ala Ser Val Val Cys Phe Leu Asn Asn Phe Tyr 
145                 150                 155                 160 


Pro Lys Asp Ile Asn Val Lys Trp Lys Ile Asp Gly Ser Glu Arg Gln 
                165                 170                 175     


Asn Gly Val Leu Asn Ser Trp Thr Asp Gln Asp Ser Lys Asp Ser Thr 
            180                 185                 190         


Tyr Ser Met Ser Ser Thr Leu Thr Leu Thr Lys Asp Glu Tyr Glu Arg 
        195                 200                 205             


His Asn Ser Tyr Thr Cys Glu Ala Thr His Lys Thr Ser Thr Ser Pro 
    210                 215                 220                 


Ile Val Lys Ser Phe Asn Arg Asn Glu Cys 
225                 230                 


<210>  23
<211>  462
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence of the heavy chain of IgG1 anti-CD33 antibody
       11D11

<400>  23

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Glu Val Asn Leu Val Glu Ser Gly Gly Gly Leu Val 
            20                  25                  30          


Gln Ser Gly Arg Ser Leu Arg Leu Ser Cys Ala Thr Ser Gly Phe Thr 
        35                  40                  45              


Phe Ser Asp Phe Tyr Met Glu Trp Val Arg Gln Ala Pro Gly Lys Gly 
    50                  55                  60                  


Leu Glu Trp Ile Ala Ala Ser Arg Asn Lys Ala Asn Asp Tyr Thr Thr 
65                  70                  75                  80  


Glu Tyr Lys Ala Ser Val Lys Gly Arg Phe Ile Val Ser Arg Asp Thr 
                85                  90                  95      


Ser Gln Ser Ile Leu Tyr Leu Gln Met Asn Ala Leu Arg Ala Glu Asp 
            100                 105                 110         


Thr Ala Ile Tyr Tyr Cys Thr Arg Asp Thr Gly Pro Met Asp Tyr Trp 
        115                 120                 125             


Gly Gln Gly Thr Ser Val Thr Val Ser Ser Ala Lys Thr Thr Pro Pro 
    130                 135                 140                 


Ser Val Tyr Pro Leu Ala Pro Gly Ser Ala Ala Gln Thr Asn Ser Met 
145                 150                 155                 160 


Val Thr Leu Gly Cys Leu Val Lys Gly Tyr Phe Pro Glu Pro Val Thr 
                165                 170                 175     


Val Thr Trp Asn Ser Gly Ser Leu Ser Ser Gly Val His Thr Phe Pro 
            180                 185                 190         


Ala Val Leu Gln Ser Asp Leu Tyr Thr Leu Ser Ser Ser Val Thr Val 
        195                 200                 205             


Pro Ser Ser Pro Arg Pro Ser Glu Thr Val Thr Cys Asn Val Ala His 
    210                 215                 220                 


Pro Ala Ser Ser Thr Lys Val Asp Lys Lys Ile Val Pro Arg Asp Cys 
225                 230                 235                 240 


Gly Cys Lys Pro Cys Ile Cys Thr Val Pro Glu Val Ser Ser Val Phe 
                245                 250                 255     


Ile Phe Pro Pro Lys Pro Lys Asp Val Leu Thr Ile Thr Leu Thr Pro 
            260                 265                 270         


Lys Val Thr Cys Val Val Val Asp Ile Ser Lys Asp Asp Pro Glu Val 
        275                 280                 285             


Gln Phe Ser Trp Phe Val Asp Asp Val Glu Val His Thr Ala Gln Thr 
    290                 295                 300                 


Gln Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg Ser Val Ser Glu 
305                 310                 315                 320 


Leu Pro Ile Met His Gln Asp Trp Leu Asn Gly Lys Glu Phe Lys Cys 
                325                 330                 335     


Arg Val Asn Ser Ala Ala Phe Pro Ala Pro Ile Glu Lys Thr Ile Ser 
            340                 345                 350         


Lys Thr Lys Gly Arg Pro Lys Ala Pro Gln Val Tyr Thr Ile Pro Pro 
        355                 360                 365             


Pro Lys Glu Gln Met Ala Lys Asp Lys Val Ser Leu Thr Cys Met Ile 
    370                 375                 380                 


Thr Asp Phe Phe Pro Glu Asp Ile Thr Val Glu Trp Gln Trp Asn Gly 
385                 390                 395                 400 


Gln Pro Ala Glu Asn Tyr Lys Asn Thr Gln Pro Ile Met Asn Thr Asn 
                405                 410                 415     


Gly Ser Tyr Phe Val Tyr Ser Lys Leu Asn Val Gln Lys Ser Asn Trp 
            420                 425                 430         


Glu Ala Gly Asn Thr Phe Thr Cys Ser Val Leu His Glu Gly Leu His 
        435                 440                 445             


Asn His His Thr Glu Lys Ser Leu Ser His Ser Pro Gly Lys 
    450                 455                 460         


<210>  24
<211>  239
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence of the light chain of IgG1 anti-CD33 antibody
       7E7

<400>  24

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Val Val Met Thr Gln Thr Pro Leu Ile Leu Ser 
            20                  25                  30          


Val Thr Ile Gly Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser 
        35                  40                  45              


Leu Leu Asp Ser Asp Gly Lys Thr Tyr Leu Ser Trp Leu Leu Gln Arg 
    50                  55                  60                  


Pro Gly Gln Ser Pro Lys Arg Leu Ile His Leu Val Ser Lys Leu Asp 
65                  70                  75                  80  


Ser Gly Val Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe 
                85                  90                  95      


Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr 
            100                 105                 110         


Cys Trp Gln Gly Thr His Phe Pro Leu Thr Phe Gly Ala Gly Thr Lys 
        115                 120                 125             


Leu Glu Leu Lys Arg Ala Asp Ala Ala Pro Thr Val Ser Ile Phe Pro 
    130                 135                 140                 


Pro Ser Ser Glu Gln Leu Thr Ser Gly Gly Ala Ser Val Val Cys Phe 
145                 150                 155                 160 


Leu Asn Asn Phe Tyr Pro Lys Asp Ile Asn Val Lys Trp Lys Ile Asp 
                165                 170                 175     


Gly Ser Glu Arg Gln Asn Gly Val Leu Asn Ser Trp Thr Asp Gln Asp 
            180                 185                 190         


Ser Lys Asp Ser Thr Tyr Ser Met Ser Ser Thr Leu Thr Leu Thr Lys 
        195                 200                 205             


Asp Glu Tyr Glu Arg His Asn Ser Tyr Thr Cys Glu Ala Thr His Lys 
    210                 215                 220                 


Thr Ser Thr Ser Pro Ile Val Lys Ser Phe Asn Arg Asn Glu Cys 
225                 230                 235                 


<210>  25
<211>  463
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence of the heavy chain of IgG1 anti-CD33 antibody
       7E7

<400>  25

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Gln Val Thr Leu Lys Glu Ser Gly Pro Gly Ile Leu 
            20                  25                  30          


Gln Pro Ser Gln Thr Leu Ser Leu Thr Cys Ser Phe Ser Gly Phe Ser 
        35                  40                  45              


Leu Asn Ser Tyr Gly Met Gly Ile Gly Trp Ile Arg Gln Pro Ser Gly 
    50                  55                  60                  


Lys Gly Leu Glu Trp Leu Ala His Ile Trp Trp Asp Asp Asn Lys Tyr 
65                  70                  75                  80  


Tyr Lys Pro Asp Leu Lys Ser Arg Leu Thr Val Ser Lys Asp Thr Ser 
                85                  90                  95      


Lys Asn Gln Val Phe Leu Lys Ile Ala Asn Val Asp Thr Thr Asp Thr 
            100                 105                 110         


Ala Thr Tyr Phe Cys Ala Arg Asp Gly Gly Tyr Ser Leu Phe Ala Tyr 
        115                 120                 125             


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Val Ala Lys Thr Thr Pro 
    130                 135                 140                 


Pro Ser Val Tyr Pro Leu Ala Pro Gly Ser Ala Ala Gln Thr Asn Ser 
145                 150                 155                 160 


Met Val Thr Leu Gly Cys Leu Val Lys Gly Tyr Phe Pro Glu Pro Val 
                165                 170                 175     


Thr Val Thr Trp Asn Ser Gly Ser Leu Ser Ser Gly Val His Thr Phe 
            180                 185                 190         


Pro Ala Val Leu Gln Ser Asp Leu Tyr Thr Leu Ser Ser Ser Val Thr 
        195                 200                 205             


Val Pro Ser Ser Pro Arg Pro Ser Glu Thr Val Thr Cys Asn Val Ala 
    210                 215                 220                 


His Pro Ala Ser Ser Thr Lys Val Asp Lys Lys Ile Val Pro Arg Asp 
225                 230                 235                 240 


Cys Gly Cys Lys Pro Cys Ile Cys Thr Val Pro Glu Val Ser Ser Val 
                245                 250                 255     


Phe Ile Phe Pro Pro Lys Pro Lys Asp Val Leu Thr Ile Thr Leu Thr 
            260                 265                 270         


Pro Lys Val Thr Cys Val Val Val Asp Ile Ser Lys Asp Asp Pro Glu 
        275                 280                 285             


Val Gln Phe Ser Trp Phe Val Asp Asp Val Glu Val His Thr Ala Gln 
    290                 295                 300                 


Thr Gln Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg Ser Val Ser 
305                 310                 315                 320 


Glu Leu Pro Ile Met His Gln Asp Trp Leu Asn Gly Lys Glu Phe Lys 
                325                 330                 335     


Cys Arg Val Asn Ser Ala Ala Phe Pro Ala Pro Ile Glu Lys Thr Ile 
            340                 345                 350         


Ser Lys Thr Lys Gly Arg Pro Lys Ala Pro Gln Val Tyr Thr Ile Pro 
        355                 360                 365             


Pro Pro Lys Glu Gln Met Ala Lys Asp Lys Val Ser Leu Thr Cys Met 
    370                 375                 380                 


Ile Thr Asp Phe Phe Pro Glu Asp Ile Thr Val Glu Trp Gln Trp Asn 
385                 390                 395                 400 


Gly Gln Pro Ala Glu Asn Tyr Lys Asn Thr Gln Pro Ile Met Asn Thr 
                405                 410                 415     


Asn Gly Ser Tyr Phe Val Tyr Ser Lys Leu Asn Val Gln Lys Ser Asn 
            420                 425                 430         


Trp Glu Ala Gly Asn Thr Phe Thr Cys Ser Val Leu His Glu Gly Leu 
        435                 440                 445             


His Asn His His Thr Glu Lys Ser Leu Ser His Ser Pro Gly Lys 
    450                 455                 460             


<210>  26
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence of human V-set Ig-like domain

<400>  26

Pro Asn Phe Trp Leu Gln Val Gln Glu Ser Val Thr Val Gln Glu Gly 
1               5                   10                  15      


Leu Cys Val Leu Val Pro Cys Thr Phe Phe His Pro Ile Pro Tyr Tyr 
            20                  25                  30          


Asp Lys Asn Ser Pro Val His Gly Tyr Trp Phe Arg Glu Gly Ala Ile 
        35                  40                  45              


Ile Ser Arg Asp Ser Pro Val Ala Thr Asn Lys Leu Asp Gln Glu Val 
    50                  55                  60                  


Gln Glu Glu Thr Gln Gly Arg Phe Arg Leu Leu Gly Asp Pro Ser Arg 
65                  70                  75                  80  


Asn Asn Cys Ser Leu Ser Ile Val Asp Ala Arg Arg Arg Asp Asn Gly 
                85                  90                  95      


Ser Tyr Phe Phe Arg Met Glu Arg Gly Ser Thr Lys Tyr Ser Tyr Lys 
            100                 105                 110         


Ser Pro Gln Leu Ser 
        115         


<210>  27
<211>  84
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence of human C2-set Ig-like domain

<400>  27

Pro Lys Ile Leu Ile Pro Gly Thr Leu Glu Pro Gly His Ser Lys Asn 
1               5                   10                  15      


Leu Thr Cys Ser Val Ser Trp Ala Cys Glu Gln Gly Thr Pro Pro Ile 
            20                  25                  30          


Phe Ser Trp Leu Ser Ala Ala Pro Thr Ser Leu Gly Pro Arg Thr Thr 
        35                  40                  45              


His Ser Ser Val Leu Ile Ile Thr Pro Arg Pro Gln Asp His Gly Thr 
    50                  55                  60                  


Asn Leu Thr Cys Gln Val Lys Phe Ala Gly Ala Gly Val Thr Thr Glu 
65                  70                  75                  80  


Arg Thr Ile Gln 
                


<210>  28
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino terminal peptide (neoepitope) in CD33 confirmed by mass 
       spectrophotometry (MS)

<400>  28

Met Pro Leu Leu Leu Leu Leu Pro Leu Leu Trp Ala Asp Leu Thr His 
1               5                   10                  15      


Arg Pro Lys 
            


<210>  29
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino terminal peptide (neoepitope) in CD33 confirmed by mass 
       spectrophotometry (MS)


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Met is oxidized

<400>  29

Met Pro Leu Leu Leu Leu Leu Pro Leu Leu Trp Ala Asp Leu Thr His 
1               5                   10                  15      


Arg Pro Lys 
            


<210>  30
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino terminal peptide (neoepitope) in CD33 confirmed by mass 
       spectrophotometry (MS)

<400>  30

Leu Leu Leu Leu Leu Pro Leu Leu Trp Ala Asp Leu Thr His Arg Pro 
1               5                   10                  15      


Lys 
    


<210>  31
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino terminal peptide (neoepitope) in CD33 confirmed by mass 
       spectrophotometry (MS)

<400>  31

Pro Leu Leu Leu Leu Leu Pro Leu Leu Trp Ala Asp Leu Thr His Arg 
1               5                   10                  15      


Pro Lys 
        


<210>  32
<211>  364
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence of human full-length CD33

<400>  32

Met Pro Leu Leu Leu Leu Leu Pro Leu Leu Trp Ala Gly Ala Leu Ala 
1               5                   10                  15      


Met Asp Pro Asn Phe Trp Leu Gln Val Gln Glu Ser Val Thr Val Gln 
            20                  25                  30          


Glu Gly Leu Cys Val Leu Val Pro Cys Thr Phe Phe His Pro Ile Pro 
        35                  40                  45              


Tyr Tyr Asp Lys Asn Ser Pro Val His Gly Tyr Trp Phe Arg Glu Gly 
    50                  55                  60                  


Ala Ile Ile Ser Arg Asp Ser Pro Val Ala Thr Asn Lys Leu Asp Gln 
65                  70                  75                  80  


Glu Val Gln Glu Glu Thr Gln Gly Arg Phe Arg Leu Leu Gly Asp Pro 
                85                  90                  95      


Ser Arg Asn Asn Cys Ser Leu Ser Ile Val Asp Ala Arg Arg Arg Asp 
            100                 105                 110         


Asn Gly Ser Tyr Phe Phe Arg Met Glu Arg Gly Ser Thr Lys Tyr Ser 
        115                 120                 125             


Tyr Lys Ser Pro Gln Leu Ser Val His Val Thr Asp Leu Thr His Arg 
    130                 135                 140                 


Pro Lys Ile Leu Ile Pro Gly Thr Leu Glu Pro Gly His Ser Lys Asn 
145                 150                 155                 160 


Leu Thr Cys Ser Val Ser Trp Ala Cys Glu Gln Gly Thr Pro Pro Ile 
                165                 170                 175     


Phe Ser Trp Leu Ser Ala Ala Pro Thr Ser Leu Gly Pro Arg Thr Thr 
            180                 185                 190         


His Ser Ser Val Leu Ile Ile Thr Pro Arg Pro Gln Asp His Gly Thr 
        195                 200                 205             


Asn Leu Thr Cys Gln Val Lys Phe Ala Gly Ala Gly Val Thr Thr Glu 
    210                 215                 220                 


Arg Thr Ile Gln Leu Asn Val Thr Tyr Val Pro Gln Asn Pro Thr Thr 
225                 230                 235                 240 


Gly Ile Phe Pro Gly Asp Gly Ser Gly Lys Gln Glu Thr Arg Ala Gly 
                245                 250                 255     


Val Val His Gly Ala Ile Gly Gly Ala Gly Val Thr Ala Leu Leu Ala 
            260                 265                 270         


Leu Cys Leu Cys Leu Ile Phe Phe Ile Val Lys Thr His Arg Arg Lys 
        275                 280                 285             


Ala Ala Arg Thr Ala Val Gly Arg Asn Asp Thr His Pro Thr Thr Gly 
    290                 295                 300                 


Ser Ala Ser Pro Lys His Gln Lys Lys Ser Lys Leu His Gly Pro Thr 
305                 310                 315                 320 


Glu Thr Ser Ser Cys Ser Gly Ala Ala Pro Thr Val Glu Met Asp Glu 
                325                 330                 335     


Glu Leu His Tyr Ala Ser Leu Asn Phe His Gly Met Asn Pro Ser Lys 
            340                 345                 350         


Asp Thr Ser Thr Glu Tyr Ser Glu Val Arg Thr Gln 
        355                 360                 


<210>  33
<211>  237
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence of the DeltaE2 version of CD33

<400>  33

Met Pro Leu Leu Leu Leu Leu Pro Leu Leu Trp Ala Asp Leu Thr His 
1               5                   10                  15      


Arg Pro Lys Ile Leu Ile Pro Gly Thr Leu Glu Pro Gly His Ser Lys 
            20                  25                  30          


Asn Leu Thr Cys Ser Val Ser Trp Ala Cys Glu Gln Gly Thr Pro Pro 
        35                  40                  45              


Ile Phe Ser Trp Leu Ser Ala Ala Pro Thr Ser Leu Gly Pro Arg Thr 
    50                  55                  60                  


Thr His Ser Ser Val Leu Ile Ile Thr Pro Arg Pro Gln Asp His Gly 
65                  70                  75                  80  


Thr Asn Leu Thr Cys Gln Val Lys Phe Ala Gly Ala Gly Val Thr Thr 
                85                  90                  95      


Glu Arg Thr Ile Gln Leu Asn Val Thr Tyr Val Pro Gln Asn Pro Thr 
            100                 105                 110         


Thr Gly Ile Phe Pro Gly Asp Gly Ser Gly Lys Gln Glu Thr Arg Ala 
        115                 120                 125             


Gly Val Val His Gly Ala Ile Gly Gly Ala Gly Val Thr Ala Leu Leu 
    130                 135                 140                 


Ala Leu Cys Leu Cys Leu Ile Phe Phe Ile Val Lys Thr His Arg Arg 
145                 150                 155                 160 


Lys Ala Ala Arg Thr Ala Val Gly Arg Asn Asp Thr His Pro Thr Thr 
                165                 170                 175     


Gly Ser Ala Ser Pro Lys His Gln Lys Lys Ser Lys Leu His Gly Pro 
            180                 185                 190         


Thr Glu Thr Ser Ser Cys Ser Gly Ala Ala Pro Thr Val Glu Met Asp 
        195                 200                 205             


Glu Glu Leu His Tyr Ala Ser Leu Asn Phe His Gly Met Asn Pro Ser 
    210                 215                 220                 


Lys Asp Thr Ser Thr Glu Tyr Ser Glu Val Arg Thr Gln 
225                 230                 235         


<210>  34
<211>  310
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence of CD33E7a which lacks most of the 
       intracellular domain of human CD33 (C-terminal truncation)

<400>  34

Met Pro Leu Leu Leu Leu Leu Pro Leu Leu Trp Ala Gly Ala Leu Ala 
1               5                   10                  15      


Met Asp Pro Asn Phe Trp Leu Gln Val Gln Glu Ser Val Thr Val Gln 
            20                  25                  30          


Glu Gly Leu Cys Val Leu Val Pro Cys Thr Phe Phe His Pro Ile Pro 
        35                  40                  45              


Tyr Tyr Asp Lys Asn Ser Pro Val His Gly Tyr Trp Phe Arg Glu Gly 
    50                  55                  60                  


Ala Ile Ile Ser Arg Asp Ser Pro Val Ala Thr Asn Lys Leu Asp Gln 
65                  70                  75                  80  


Glu Val Gln Glu Glu Thr Gln Gly Arg Phe Arg Leu Leu Gly Asp Pro 
                85                  90                  95      


Ser Arg Asn Asn Cys Ser Leu Ser Ile Val Asp Ala Arg Arg Arg Asp 
            100                 105                 110         


Asn Gly Ser Tyr Phe Phe Arg Met Glu Arg Gly Ser Thr Lys Tyr Ser 
        115                 120                 125             


Tyr Lys Ser Pro Gln Leu Ser Val His Val Thr Asp Leu Thr His Arg 
    130                 135                 140                 


Pro Lys Ile Leu Ile Pro Gly Thr Leu Glu Pro Gly His Ser Lys Asn 
145                 150                 155                 160 


Leu Thr Cys Ser Val Ser Trp Ala Cys Glu Gln Gly Thr Pro Pro Ile 
                165                 170                 175     


Phe Ser Trp Leu Ser Ala Ala Pro Thr Ser Leu Gly Pro Arg Thr Thr 
            180                 185                 190         


His Ser Ser Val Leu Ile Ile Thr Pro Arg Pro Gln Asp His Gly Thr 
        195                 200                 205             


Asn Leu Thr Cys Gln Val Lys Phe Ala Gly Ala Gly Val Thr Thr Glu 
    210                 215                 220                 


Arg Thr Ile Gln Leu Asn Val Thr Tyr Val Pro Gln Asn Pro Thr Thr 
225                 230                 235                 240 


Gly Ile Phe Pro Gly Asp Gly Ser Gly Lys Gln Glu Thr Arg Ala Gly 
                245                 250                 255     


Val Val His Gly Ala Ile Gly Gly Ala Gly Val Thr Ala Leu Leu Ala 
            260                 265                 270         


Leu Cys Leu Cys Leu Ile Phe Phe Ile Val Lys Thr His Arg Arg Lys 
        275                 280                 285             


Ala Ala Arg Thr Ala Val Gly Arg Asn Asp Thr His Pro Thr Thr Gly 
    290                 295                 300                 


Ser Ala Ser Pro Val Arg 
305                 310 


<210>  35
<211>  282
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence of cynomolgus CD33

<400>  35

Met Pro Leu Leu Leu Leu Pro Leu Leu Trp Ala Gly Ala Leu Ala Met 
1               5                   10                  15      


Asp Pro Arg Val Arg Leu Glu Val Gln Glu Ser Val Thr Val Gln Glu 
            20                  25                  30          


Gly Leu Cys Val Leu Val Pro Cys Thr Phe Phe His Pro Val Pro Tyr 
        35                  40                  45              


His Thr Arg Asn Ser Pro Val His Gly Tyr Trp Phe Arg Glu Gly Ala 
    50                  55                  60                  


Ile Val Ser Leu Asp Ser Pro Val Ala Thr Asn Lys Leu Asp Gln Glu 
65                  70                  75                  80  


Val Gln Glu Glu Thr Gln Gly Arg Phe Arg Leu Leu Gly Asp Pro Ser 
                85                  90                  95      


Arg Asn Asn Cys Ser Leu Ser Ile Val Asp Ala Arg Arg Arg Asp Asn 
            100                 105                 110         


Gly Ser Tyr Phe Phe Arg Met Glu Lys Gly Ser Thr Lys Tyr Ser Tyr 
        115                 120                 125             


Lys Ser Thr Gln Leu Ser Val His Val Thr Asp Leu Thr His Arg Pro 
    130                 135                 140                 


Gln Ile Leu Ile Pro Gly Ala Leu Asp Pro Asp His Ser Lys Asn Leu 
145                 150                 155                 160 


Thr Cys Ser Val Pro Trp Ala Cys Glu Gln Gly Thr Pro Pro Ile Phe 
                165                 170                 175     


Ser Trp Met Ser Ala Ala Pro Thr Ser Leu Gly Leu Arg Thr Thr His 
            180                 185                 190         


Ser Ser Val Leu Ile Ile Thr Pro Arg Pro Gln Asp His Gly Thr Asn 
        195                 200                 205             


Leu Thr Cys Gln Val Lys Phe Pro Gly Ala Gly Val Thr Thr Glu Arg 
    210                 215                 220                 


Thr Ile Gln Leu Asn Val Ser Tyr Ala Ser Gln Asn Pro Arg Thr Asp 
225                 230                 235                 240 


Ile Phe Leu Gly Asp Gly Ser Gly Arg Lys Ala Arg Lys Gln Gly Val 
                245                 250                 255     


Val Gln Gly Ala Ile Gly Gly Ala Gly Val Thr Val Leu Leu Ala Leu 
            260                 265                 270         


Cys Leu Cys Leu Ile Phe Phe Thr Val Gln 
        275                 280         


<210>  36
<211>  283
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence of human CD33 (HsCD33_P20138) shown in the 
       alignment in FIG. 2

<400>  36

Met Pro Leu Leu Leu Leu Leu Pro Leu Leu Trp Ala Gly Ala Leu Ala 
1               5                   10                  15      


Met Asp Pro Asn Phe Trp Leu Gln Val Gln Glu Ser Val Thr Val Gln 
            20                  25                  30          


Glu Gly Leu Cys Val Leu Val Pro Cys Thr Phe Phe His Pro Ile Pro 
        35                  40                  45              


Tyr Tyr Asp Lys Asn Ser Pro Val His Gly Tyr Trp Phe Arg Glu Gly 
    50                  55                  60                  


Ala Ile Ile Ser Arg Asp Ser Pro Val Ala Thr Asn Lys Leu Asp Gln 
65                  70                  75                  80  


Glu Val Gln Glu Glu Thr Gln Gly Arg Phe Arg Leu Leu Gly Asp Pro 
                85                  90                  95      


Ser Arg Asn Asn Cys Ser Leu Ser Ile Val Asp Ala Arg Arg Arg Asp 
            100                 105                 110         


Asn Gly Ser Tyr Phe Phe Arg Met Glu Arg Gly Ser Thr Lys Tyr Ser 
        115                 120                 125             


Tyr Lys Ser Pro Gln Leu Ser Val His Val Thr Asp Leu Thr His Arg 
    130                 135                 140                 


Pro Lys Ile Leu Ile Pro Gly Thr Leu Glu Pro Gly His Ser Lys Asn 
145                 150                 155                 160 


Leu Thr Cys Ser Val Ser Trp Ala Cys Glu Gln Gly Thr Pro Pro Ile 
                165                 170                 175     


Phe Ser Trp Leu Ser Ala Ala Pro Thr Ser Leu Gly Pro Arg Thr Thr 
            180                 185                 190         


His Ser Ser Val Leu Ile Ile Thr Pro Arg Pro Gln Asp His Gly Thr 
        195                 200                 205             


Asn Leu Thr Cys Gln Val Lys Phe Ala Gly Ala Gly Val Thr Thr Glu 
    210                 215                 220                 


Arg Thr Ile Gln Leu Asn Val Thr Tyr Val Pro Gln Asn Pro Thr Thr 
225                 230                 235                 240 


Gly Ile Phe Pro Gly Asp Gly Ser Gly Lys Gln Glu Thr Arg Ala Gly 
                245                 250                 255     


Val Val His Gly Ala Ile Gly Gly Ala Gly Val Thr Ala Leu Leu Ala 
            260                 265                 270         


Leu Cys Leu Cys Leu Ile Phe Phe Ile Val Gln 
        275                 280             


<210>  37
<211>  267
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence of murine CD33 (MmCD33_Q63994) shown in the 
       alignment in FIG. 2

<400>  37

Met Leu Trp Pro Leu Pro Leu Phe Leu Leu Cys Ala Gly Ser Leu Ala 
1               5                   10                  15      


Gln Asp Leu Glu Phe Gln Leu Val Ala Pro Glu Ser Val Thr Val Glu 
            20                  25                  30          


Glu Gly Leu Cys Val His Val Pro Cys Ser Val Phe Tyr Pro Ser Ile 
        35                  40                  45              


Lys Leu Thr Leu Gly Pro Val Thr Gly Ser Trp Leu Arg Lys Gly Val 
    50                  55                  60                  


Ser Leu His Glu Asp Ser Pro Val Ala Thr Ser Asp Pro Arg Gln Leu 
65                  70                  75                  80  


Val Gln Lys Ala Thr Gln Gly Arg Phe Gln Leu Leu Gly Asp Pro Gln 
                85                  90                  95      


Lys His Asp Cys Ser Leu Phe Ile Arg Asp Ala Gln Lys Asn Asp Thr 
            100                 105                 110         


Gly Met Tyr Phe Phe Arg Val Val Arg Glu Pro Phe Val Arg Tyr Ser 
        115                 120                 125             


Tyr Lys Lys Ser Gln Leu Ser Leu His Val Thr Ser Leu Ser Arg Thr 
    130                 135                 140                 


Pro Asp Ile Ile Ile Pro Gly Thr Leu Glu Ala Gly Tyr Pro Ser Asn 
145                 150                 155                 160 


Leu Thr Cys Ser Val Pro Trp Ala Cys Glu Gln Gly Thr Pro Pro Thr 
                165                 170                 175     


Phe Ser Trp Met Ser Thr Ala Leu Thr Ser Leu Ser Ser Arg Thr Thr 
            180                 185                 190         


Asp Ser Ser Val Leu Thr Phe Thr Pro Gln Pro Gln Asp His Gly Thr 
        195                 200                 205             


Lys Leu Thr Cys Leu Val Thr Phe Ser Gly Ala Gly Val Thr Val Glu 
    210                 215                 220                 


Arg Thr Ile Gln Leu Asn Val Thr Arg Lys Ser Gly Gln Met Arg Glu 
225                 230                 235                 240 


Leu Val Leu Val Ala Val Gly Glu Ala Thr Val Lys Leu Leu Ile Leu 
                245                 250                 255     


Gly Leu Cys Leu Val Phe Leu Ile Val Met Phe 
            260                 265         


<210>  38
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL1 of anti-CD3 antibody OKT3

<400>  38

Ser Ala Ser Ser Ser Val Ser Tyr Met Asn 
1               5                   10  


<210>  39
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL2 of anti-CD3 antibody OKT3

<400>  39

Arg Trp Ile Tyr Asp Thr Ser Lys Leu Ala Ser 
1               5                   10      


<210>  40
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL3 of anti-CD3 antibody OKT3

<400>  40

Gln Gln Trp Ser Ser Asn Pro Phe Thr 
1               5                   


<210>  41
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH1 of anti-CD3 antibody OKT3

<400>  41

Lys Ala Ser Gly Tyr Thr Phe Thr Arg Tyr Thr Met His 
1               5                   10              


<210>  42
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH2 of anti-CD3 antibody OKT3

<400>  42

Ile Asn Pro Ser Arg Gly Tyr Thr Asn Tyr Asn Gln Lys Phe Lys Asp 
1               5                   10                  15      


<210>  43
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH3 of anti-CD3 antibody OKT3

<400>  43

Tyr Tyr Asp Asp His Tyr Cys Leu Asp Tyr 
1               5                   10  


<210>  44
<211>  242
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence of a scFv derived from OKT3 which retains the
       capacity to bind CD3

<400>  44

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Ala Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Arg Tyr 
            20                  25                  30          


Thr Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Pro Ser Arg Gly Tyr Thr Asn Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asp Lys Ala Thr Leu Thr Thr Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Tyr Tyr Asp Asp His Tyr Cys Leu Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Leu Thr Val Ser Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gln Ile Val Leu Thr Gln Ser Pro Ala 
    130                 135                 140                 


Ile Met Ser Ala Ser Pro Gly Glu Lys Val Thr Met Thr Cys Ser Ala 
145                 150                 155                 160 


Ser Ser Ser Val Ser Tyr Met Asn Trp Tyr Gln Gln Lys Ser Gly Thr 
                165                 170                 175     


Ser Pro Lys Arg Trp Ile Tyr Asp Thr Ser Lys Leu Ala Ser Gly Val 
            180                 185                 190         


Pro Ala His Phe Arg Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr 
        195                 200                 205             


Ile Ser Gly Met Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln 
    210                 215                 220                 


Trp Ser Ser Asn Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile 
225                 230                 235                 240 


Asn Arg 
        


<210>  45
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL1 of anti-CD3 antibody 20G6-F3

<400>  45

Gln Ser Leu Val His Asn Asn Gly Asn Thr Tyr 
1               5                   10      


<210>  46

<400>  46
000

<210>  47
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL3 of anti-CD3 antibody 20G6-F3

<400>  47

Gly Gln Gly Thr Gln Tyr Pro Phe Thr 
1               5                   


<210>  48
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH1 of anti-CD3 antibody 20G6-F3

<400>  48

Gly Phe Thr Phe Thr Lys Ala Trp 
1               5               


<210>  49
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH2 of anti-CD3 antibody 20G6-F3

<400>  49

Ile Lys Asp Lys Ser Asn Ser Tyr Ala Thr 
1               5                   10  


<210>  50
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH3 of anti-CD3 antibody 20G6-F3

<400>  50

Arg Gly Val Tyr Tyr Ala Leu Ser Pro Phe Asp Tyr 
1               5                   10          


<210>  51
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL1 of anti-CD3 antibody 4B4-D7

<400>  51

Gln Ser Leu Val His Asp Asn Gly Asn Thr Tyr 
1               5                   10      


<210>  52

<400>  52
000

<210>  53
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL3 of anti-CD3 antibody 4B4-D7

<400>  53

Gly Gln Gly Thr Gln Tyr Pro Phe Thr 
1               5                   


<210>  54
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH1 of anti-CD3 antibody 4B4-D7

<400>  54

Gly Phe Thr Phe Ser Asn Ala Trp 
1               5               


<210>  55
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH2 of anti-CD3 antibody 4B4-D7

<400>  55

Ile Lys Ala Arg Ser Asn Asn Tyr Ala Thr 
1               5                   10  


<210>  56
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH3 of anti-CD3 antibody 4B4-D7

<400>  56

Arg Gly Thr Tyr Tyr Ala Ser Lys Pro Phe Asp Tyr 
1               5                   10          


<210>  57
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL1 of anti-CD3 antibody 4E7-C9

<400>  57

Gln Ser Leu Glu His Asn Asn Gly Asn Thr Tyr 
1               5                   10      


<210>  58

<400>  58
000

<210>  59
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL3 of anti-CD3 antibody 4E7-C9

<400>  59

Gly Gln Gly Thr Gln Tyr Pro Phe Thr 
1               5                   


<210>  60
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH1 of anti-CD3 antibody 4E7-C9

<400>  60

Gly Phe Thr Phe Ser Asn Ala Trp 
1               5               


<210>  61
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH2 of anti-CD3 antibody 4E7-C9

<400>  61

Ile Lys Asp Lys Ser Asn Asn Tyr Ala Thr 
1               5                   10  


<210>  62
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH3 of anti-CD3 antibody 4E7-C9

<400>  62

Arg Tyr Val His Tyr Gly Ile Gly Tyr Ala Met Asp Ala 
1               5                   10              


<210>  63
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL1 of anti-CD3 antibody 18F5-H10

<400>  63

Gln Ser Leu Val His Thr Asn Gly Asn Thr Tyr 
1               5                   10      


<210>  64

<400>  64
000

<210>  65
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL3 of anti-CD3 antibody 18F5-H10

<400>  65

Gly Gln Gly Thr His Tyr Pro Phe Thr 
1               5                   


<210>  66
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH1 of anti-CD3 antibody 18F5-H10

<400>  66

Gly Phe Thr Phe Thr Asn Ala Trp 
1               5               


<210>  67
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH2 of anti-CD3 antibody 18F5-H10

<400>  67

Lys Asp Lys Ser Asn Asn Tyr Ala Thr 
1               5                   


<210>  68
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH3 of anti-CD3 antibody 18F5-H10

<400>  68

Arg Tyr Val His Tyr Arg Phe Ala Tyr Ala Leu Asp Ala 
1               5                   10              


<210>  69
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL1 of anti-CD8 antibody OKT8

<400>  69

Arg Thr Ser Arg Ser Ile Ser Gln Tyr Leu Ala 
1               5                   10      


<210>  70
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL2 of anti-CD8 antibody OKT8

<400>  70

Ser Gly Ser Thr Leu Gln Ser 
1               5           


<210>  71
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL3 of anti-CD8 antibody OKT8

<400>  71

Gln Gln His Asn Glu Asn Pro Leu Thr 
1               5                   


<210>  72
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH1 of anti-CD8 antibody OKT8

<400>  72

Gly Phe Asn Ile Lys Asp 
1               5       


<210>  73
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH2 of anti-CD8 antibody OKT8

<400>  73

Arg Ile Asp Pro Ala Asn Asp Asn Thr 
1               5                   


<210>  74
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH3 of anti-CD8 antibody OKT8

<400>  74

Gly Tyr Gly Tyr Tyr Val Phe Asp His 
1               5                   


<210>  75
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence of a variable light chain region of the 
       sequence of a binding domain that binds and blocks the NK cell 
       inhibitory receptors KIR2DL1 and KIR2DL2/3

<400>  75

Glu Ile Val Leu Thr Gln Ser Pro Val Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Ser Asn Trp Met Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Thr 
            100                 105                 


<210>  76
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence of a variable heavy chain region of the 
       sequence of a binding domain that binds and blocks the NK cell 
       inhibitory receptors KIR2DL1 and KIR2DL2/3

<400>  76

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Phe Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Phe Ile Pro Ile Phe Gly Ala Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ile Pro Ser Gly Ser Tyr Tyr Tyr Asp Tyr Asp Met Asp Val 
            100                 105                 110         


Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120             


<210>  77
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker

<400>  77

Gly Gly Ser Gly Gly Gly Ser Gly Gly Ser Gly 
1               5                   10      


<210>  78
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker

<400>  78

Gly Gly Ser Gly Gly Gly Ser Gly Ser Gly 
1               5                   10  


<210>  79
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker

<400>  79

Gly Gly Ser Gly Gly Gly Ser Gly 
1               5               


<210>  80
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker

<400>  80

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10  


<210>  81
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker

<400>  81

Gly Gly Gly Ser Gly Gly Gly Ser 
1               5               


<210>  82
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker

<400>  82

Gly Gly Ser Gly Gly Ser 
1               5       


<210>  83
<211>  467
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence of the heavy chain of anti-CD33 antibody 1H7

<400>  83

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val 
            20                  25                  30          


Lys Pro Gly Ala Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ala 
        35                  40                  45              


Phe Ser Asn Tyr Trp Met Asn Trp Val Lys Gln Arg Pro Gly Lys Gly 
    50                  55                  60                  


Leu Glu Trp Ile Gly Gln Ile Asn Pro Gly Asp Gly Asp Thr Asn Tyr 
65                  70                  75                  80  


Asn Gly Lys Phe Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser 
                85                  90                  95      


Ser Thr Ala Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala 
            100                 105                 110         


Val Tyr Phe Cys Ala Arg Glu Asp Arg Asp Tyr Phe Asp Tyr Trp Gly 
        115                 120                 125             


Gln Gly Thr Thr Leu Thr Val Ser Ser Ala Lys Thr Thr Ala Pro Ser 
    130                 135                 140                 


Val Tyr Pro Leu Ala Pro Val Cys Gly Asp Thr Thr Gly Ser Ser Val 
145                 150                 155                 160 


Thr Leu Gly Cys Leu Val Lys Gly Tyr Phe Pro Glu Pro Val Thr Leu 
                165                 170                 175     


Thr Trp Asn Ser Gly Ser Leu Ser Ser Gly Val His Thr Phe Pro Ala 
            180                 185                 190         


Val Leu Gln Ser Asp Leu Tyr Thr Leu Ser Ser Ser Val Thr Val Thr 
        195                 200                 205             


Ser Ser Thr Trp Pro Ser Gln Ser Ile Thr Cys Asn Val Ala His Pro 
    210                 215                 220                 


Ala Ser Ser Thr Lys Val Asp Lys Lys Ile Glu Pro Arg Gly Pro Thr 
225                 230                 235                 240 


Ile Lys Pro Cys Pro Pro Cys Lys Cys Pro Ala Pro Asn Leu Leu Gly 
                245                 250                 255     


Gly Pro Ser Val Phe Ile Phe Pro Pro Lys Ile Lys Asp Val Leu Met 
            260                 265                 270         


Ile Ser Leu Ser Pro Ile Val Thr Cys Val Val Val Asp Val Ser Glu 
        275                 280                 285             


Asp Asp Pro Asp Val Gln Ile Ser Trp Phe Val Asn Asn Val Glu Val 
    290                 295                 300                 


His Thr Ala Gln Thr Gln Thr His Arg Glu Asp Tyr Asn Ser Thr Leu 
305                 310                 315                 320 


Arg Val Val Ser Ala Leu Pro Ile Gln His Gln Asp Trp Met Ser Gly 
                325                 330                 335     


Lys Glu Phe Lys Cys Lys Val Asn Asn Lys Asp Leu Pro Ala Pro Ile 
            340                 345                 350         


Glu Arg Thr Ile Ser Lys Pro Lys Gly Ser Val Arg Ala Pro Gln Val 
        355                 360                 365             


Tyr Val Leu Pro Pro Pro Glu Glu Glu Met Thr Lys Lys Gln Val Thr 
    370                 375                 380                 


Leu Thr Cys Met Val Thr Asp Phe Met Pro Glu Asp Ile Tyr Val Glu 
385                 390                 395                 400 


Trp Thr Asn Asn Gly Lys Thr Glu Leu Asn Tyr Lys Asn Thr Glu Pro 
                405                 410                 415     


Val Leu Asp Ser Asp Gly Ser Tyr Phe Met Tyr Ser Lys Leu Arg Val 
            420                 425                 430         


Glu Lys Lys Asn Trp Val Glu Arg Asn Ser Tyr Ser Cys Ser Val Val 
        435                 440                 445             


His Glu Gly Leu His Asn His His Thr Thr Lys Ser Phe Ser Arg Thr 
    450                 455                 460                 


Pro Gly Lys 
465         


<210>  84
<211>  234
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence of the light chain of anti-CD33 antibody 1H7

<400>  84

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser 
            20                  25                  30          


Ala Ser Leu Gly Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp 
        35                  40                  45              


Ile Asn Tyr Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val 
    50                  55                  60                  


Lys Leu Leu Ile Tyr Tyr Ser Ser Arg Leu His Ser Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Ser Leu Thr Ile Ser 
                85                  90                  95      


Asn Leu Glu Gln Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Asp Asp 
            100                 105                 110         


Ala Leu Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg 
        115                 120                 125             


Ala Asp Ala Ala Pro Thr Val Ser Ile Phe Pro Pro Ser Ser Glu Gln 
    130                 135                 140                 


Leu Thr Ser Gly Gly Ala Ser Val Val Cys Phe Leu Asn Asn Phe Tyr 
145                 150                 155                 160 


Pro Lys Asp Ile Asn Val Lys Trp Lys Ile Asp Gly Ser Glu Arg Gln 
                165                 170                 175     


Asn Gly Val Leu Asn Ser Trp Thr Asp Gln Asp Ser Lys Asp Ser Thr 
            180                 185                 190         


Tyr Ser Met Ser Ser Thr Leu Thr Leu Thr Lys Asp Glu Tyr Glu Arg 
        195                 200                 205             


His Asn Ser Tyr Thr Cys Glu Ala Thr His Lys Thr Ser Thr Ser Pro 
    210                 215                 220                 


Ile Val Lys Ser Phe Asn Arg Asn Glu Cys 
225                 230                 


<210>  85
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL1 of anti-CD33 antibody 1H7

<400>  85

Arg Ala Ser Gln Asp Ile Asn Tyr Tyr Leu Asn 
1               5                   10      


<210>  86
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL2 of anti-CD33 antibody 1H7

<400>  86

Tyr Ser Ser Arg Leu His Ser Gly 
1               5               


<210>  87
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL3 of anti-CD33 antibody 1H7

<400>  87

Gln Gln Asp Asp Ala Leu Pro Tyr Thr 
1               5                   


<210>  88
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH1 of anti-CD33 antibody 1H7

<400>  88

Gly Tyr Ala Phe Ser Asn Tyr Trp Met Asn 
1               5                   10  


<210>  89
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH2 of anti-CD33 antibody 1H7

<400>  89

Gln Ile Asn Pro Gly Asp Gly Asp Thr Asn Tyr Asn Gly 
1               5                   10              


<210>  90
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH3 of anti-CD33 antibody 1H7

<400>  90

Glu Asp Arg Asp Tyr Phe Asp Tyr 
1               5               


<210>  91
<211>  519
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence of a 1H7-CD3 BiTE (based on SEQ ID 83/84)

<400>  91

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser 
            20                  25                  30          


Ala Ser Leu Gly Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp 
        35                  40                  45              


Ile Asn Tyr Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val 
    50                  55                  60                  


Lys Leu Leu Ile Tyr Tyr Ser Ser Arg Leu His Ser Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Ser Leu Thr Ile Ser 
                85                  90                  95      


Asn Leu Glu Gln Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Asp Asp 
            100                 105                 110         


Ala Leu Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val 
    130                 135                 140                 


Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Lys Pro Gly Ala Ser Val 
145                 150                 155                 160 


Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ala Phe Ser Asn Tyr Trp Met 
                165                 170                 175     


Asn Trp Val Lys Gln Arg Pro Gly Lys Gly Leu Glu Trp Ile Gly Gln 
            180                 185                 190         


Ile Asn Pro Gly Asp Gly Asp Thr Asn Tyr Asn Gly Lys Phe Lys Gly 
        195                 200                 205             


Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr Met Gln 
    210                 215                 220                 


Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys Ala Arg 
225                 230                 235                 240 


Glu Asp Arg Asp Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr 
                245                 250                 255     


Val Ser Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly 
            260                 265                 270         


Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala 
        275                 280                 285             


Ser Gly Phe Thr Phe Asn Lys Tyr Ala Met Asn Trp Val Arg Gln Ala 
    290                 295                 300                 


Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Arg Ser Lys Tyr Asn 
305                 310                 315                 320 


Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser Val Lys Asp Arg Phe Thr Ile 
                325                 330                 335     


Ser Arg Asp Asp Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Asn Leu 
            340                 345                 350         


Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Val Arg His Gly Asn Phe 
        355                 360                 365             


Gly Asn Ser Tyr Ile Ser Tyr Trp Ala Tyr Trp Gly Gln Gly Thr Leu 
    370                 375                 380                 


Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
385                 390                 395                 400 


Gly Gly Gly Ser Gln Thr Val Val Thr Gln Glu Pro Ser Leu Thr Val 
                405                 410                 415     


Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala 
            420                 425                 430         


Val Thr Ser Gly Asn Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly Gln 
        435                 440                 445             


Ala Pro Arg Gly Leu Ile Gly Gly Thr Lys Phe Leu Ala Pro Gly Thr 
    450                 455                 460                 


Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr 
465                 470                 475                 480 


Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Val Leu 
                485                 490                 495     


Trp Tyr Ser Asn Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val 
            500                 505                 510         


Leu His His His His His His 
        515                 


<210>  92
<211>  504
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence of a light chain 1H7-CD3 engager (based on 
       SEQ ID 84)

<400>  92

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser 
            20                  25                  30          


Ala Ser Leu Gly Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp 
        35                  40                  45              


Ile Asn Tyr Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val 
    50                  55                  60                  


Lys Leu Leu Ile Tyr Tyr Ser Ser Arg Leu His Ser Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Ser Leu Thr Ile Ser 
                85                  90                  95      


Asn Leu Glu Gln Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Asp Asp 
            100                 105                 110         


Ala Leu Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg 
        115                 120                 125             


Ala Asp Ala Ala Pro Thr Val Ser Ile Phe Pro Pro Ser Ser Glu Gln 
    130                 135                 140                 


Leu Thr Ser Gly Gly Ala Ser Val Val Cys Phe Leu Asn Asn Phe Tyr 
145                 150                 155                 160 


Pro Lys Asp Ile Asn Val Lys Trp Lys Ile Asp Gly Ser Glu Arg Gln 
                165                 170                 175     


Asn Gly Val Leu Asn Ser Trp Thr Asp Gln Asp Ser Lys Asp Ser Thr 
            180                 185                 190         


Tyr Ser Met Ser Ser Thr Leu Thr Leu Thr Lys Asp Glu Tyr Glu Arg 
        195                 200                 205             


His Asn Ser Tyr Thr Cys Glu Ala Thr His Lys Thr Ser Thr Ser Pro 
    210                 215                 220                 


Ile Val Lys Ser Phe Asn Arg Asn Glu Cys Gly Gly Gly Gly Ser Gly 
225                 230                 235                 240 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser 
                245                 250                 255     


Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala 
            260                 265                 270         


Ala Ser Gly Phe Thr Phe Asn Lys Tyr Ala Met Asn Trp Val Arg Gln 
        275                 280                 285             


Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Arg Ser Lys Tyr 
    290                 295                 300                 


Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser Val Lys Asp Arg Phe Thr 
305                 310                 315                 320 


Ile Ser Arg Asp Asp Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Asn 
                325                 330                 335     


Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Val Arg His Gly Asn 
            340                 345                 350         


Phe Gly Asn Ser Tyr Ile Ser Tyr Trp Ala Tyr Trp Gly Gln Gly Thr 
        355                 360                 365             


Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    370                 375                 380                 


Gly Gly Gly Gly Ser Gln Thr Val Val Thr Gln Glu Pro Ser Leu Thr 
385                 390                 395                 400 


Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly 
                405                 410                 415     


Ala Val Thr Ser Gly Asn Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly 
            420                 425                 430         


Gln Ala Pro Arg Gly Leu Ile Gly Gly Thr Lys Phe Leu Ala Pro Gly 
        435                 440                 445             


Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu 
    450                 455                 460                 


Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Val 
465                 470                 475                 480 


Leu Trp Tyr Ser Asn Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr 
                485                 490                 495     


Val Leu His His His His His His 
            500                 


<210>  93
<211>  467
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence of a heavy chain 1H7-CD3 engager (based on 
       SEQ ID 83)

<400>  93

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val 
            20                  25                  30          


Lys Pro Gly Ala Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ala 
        35                  40                  45              


Phe Ser Asn Tyr Trp Met Asn Trp Val Lys Gln Arg Pro Gly Lys Gly 
    50                  55                  60                  


Leu Glu Trp Ile Gly Gln Ile Asn Pro Gly Asp Gly Asp Thr Asn Tyr 
65                  70                  75                  80  


Asn Gly Lys Phe Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser 
                85                  90                  95      


Ser Thr Ala Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala 
            100                 105                 110         


Val Tyr Phe Cys Ala Arg Glu Asp Arg Asp Tyr Phe Asp Tyr Trp Gly 
        115                 120                 125             


Gln Gly Thr Thr Leu Thr Val Ser Ser Ala Lys Thr Thr Ala Pro Ser 
    130                 135                 140                 


Val Tyr Pro Leu Ala Pro Val Cys Gly Asp Thr Thr Gly Ser Ser Val 
145                 150                 155                 160 


Thr Leu Gly Cys Leu Val Lys Gly Tyr Phe Pro Glu Pro Val Thr Leu 
                165                 170                 175     


Thr Trp Asn Ser Gly Ser Leu Ser Ser Gly Val His Thr Phe Pro Ala 
            180                 185                 190         


Val Leu Gln Ser Asp Leu Tyr Thr Leu Ser Ser Ser Val Thr Val Thr 
        195                 200                 205             


Ser Ser Thr Trp Pro Ser Gln Ser Ile Thr Cys Asn Val Ala His Pro 
    210                 215                 220                 


Ala Ser Ser Thr Lys Val Asp Lys Lys Ile Glu Pro Arg Gly Pro Thr 
225                 230                 235                 240 


Ile Lys Pro Cys Pro Pro Cys Lys Cys Pro Ala Pro Asn Leu Leu Gly 
                245                 250                 255     


Gly Pro Ser Val Phe Ile Phe Pro Pro Lys Ile Lys Asp Val Leu Met 
            260                 265                 270         


Ile Ser Leu Ser Pro Ile Val Thr Cys Val Val Val Asp Val Ser Glu 
        275                 280                 285             


Asp Asp Pro Asp Val Gln Ile Ser Trp Phe Val Asn Asn Val Glu Val 
    290                 295                 300                 


His Thr Ala Gln Thr Gln Thr His Arg Glu Asp Tyr Asn Ser Thr Leu 
305                 310                 315                 320 


Arg Val Val Ser Ala Leu Pro Ile Gln His Gln Asp Trp Met Ser Gly 
                325                 330                 335     


Lys Glu Phe Lys Cys Lys Val Asn Asn Lys Asp Leu Pro Ala Pro Ile 
            340                 345                 350         


Glu Arg Thr Ile Ser Lys Pro Lys Gly Ser Val Arg Ala Pro Gln Val 
        355                 360                 365             


Tyr Val Leu Pro Pro Pro Glu Glu Glu Met Thr Lys Lys Gln Val Thr 
    370                 375                 380                 


Leu Thr Cys Met Val Thr Asp Phe Met Pro Glu Asp Ile Tyr Val Glu 
385                 390                 395                 400 


Trp Thr Asn Asn Gly Lys Thr Glu Leu Asn Tyr Lys Asn Thr Glu Pro 
                405                 410                 415     


Val Leu Asp Ser Asp Gly Ser Tyr Phe Met Tyr Ser Lys Leu Arg Val 
            420                 425                 430         


Glu Lys Lys Asn Trp Val Glu Arg Asn Ser Tyr Ser Cys Ser Val Val 
        435                 440                 445             


His Glu Gly Leu His Asn His His Thr Thr Lys Ser Phe Ser Arg Thr 
    450                 455                 460                 


Pro Gly Lys 
465         


<210>  94
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH1 of anti-CD33 antibody 5D12

<400>  94

Gly Tyr Ala Phe Ser Asn Tyr Trp Met Asn 
1               5                   10  


<210>  95
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH2 of anti-CD33 antibody 5D12

<400>  95

Gln Ile Tyr Pro Gly Asn Phe Asn Thr Asp Tyr Asn Gly Gln Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  96
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH3 of anti-CD33 antibody 5D12

<400>  96

Phe Phe Asp Phe Gly Ala Tyr Phe Thr Leu Asp Tyr 
1               5                   10          


<210>  97
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL1 of anti-CD33 antibody 5D12

<400>  97

Lys Ala Ser Gln Asp Ile Lys Ser Tyr Leu Ser 
1               5                   10      


<210>  98
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL2 of anti-CD33 antibody 5D12

<400>  98

Tyr Ala Thr Thr Leu Ala Asp 
1               5           


<210>  99
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL3 of anti-CD33 antibody 5D12

<400>  99

Leu His His Gly Glu Ser Pro Trp Thr 
1               5                   


<210>  100
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH1 of anti-CD33 antibody 8F5

<400>  100

Ser Gly Phe Thr Phe Ser Asp Phe Tyr Met Tyr 
1               5                   10      


<210>  101
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH2 of anti-CD33 antibody 8F5

<400>  101

Phe Ile Ser Asn Ala Gly Val Thr Thr Tyr Tyr Pro Asp Thr Val Glu 
1               5                   10                  15      


Gly 
    


<210>  102
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH3 of anti-CD33 antibody 8F5

<400>  102

Ser Asp Tyr Asp Gly Ala Trp Phe Pro Tyr 
1               5                   10  


<210>  103
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL1 of anti-CD33 antibody 8F5

<400>  103

Lys Ser Ser Gln Ser Leu Leu Tyr Ser Arg Asn Gln Tyr Asn Phe Leu 
1               5                   10                  15      


Ala 
    


<210>  104
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL2 of anti-CD33 antibody 8F5

<400>  104

Trp Ala Ser Thr Arg Glu Ser 
1               5           


<210>  105
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL3 of anti-CD33 antibody 8F5

<400>  105

Gln Gln Tyr Tyr Ser Tyr Pro Tyr Thr 
1               5                   


<210>  106
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH1 of anti-CD33 antibody 12B12

<400>  106

Gly Tyr Thr Phe Thr Thr Tyr Trp Met His 
1               5                   10  


<210>  107
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH2 of anti-CD33 antibody 12B12

<400>  107

Ala Ile Tyr Pro Gly Asn Ser Asp Thr Ser Tyr Asn Gln 
1               5                   10              


<210>  108
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH3 of anti-CD33 antibody 12B12

<400>  108

Tyr Asp Gly Tyr His Phe Ile 
1               5           


<210>  109
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL1 of anti-CD33 antibody 12B12

<400>  109

Arg Ser Ser Gln Ser Leu Leu His Ser Asn Gly Ile Thr Tyr Leu Tyr 
1               5                   10                  15      


<210>  110
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL2 of anti-CD33 antibody 12B12

<400>  110

Gln Met Ser Asn Leu Ala Ser 
1               5           


<210>  111
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL3 of anti-CD33 antibody 12B12

<400>  111

Ala Gln Asn Leu Glu Leu Pro Pro Thr 
1               5                   


<210>  112
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH1 of anti-CD33 antibody 4H10

<400>  112

Gly Tyr Ala Phe Thr Asn Tyr Leu Ile Glu 
1               5                   10  


<210>  113
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH2 of anti-CD33 antibody 4H10

<400>  113

Val Ile His Pro Gly Asn Asn Ser Thr Ser Tyr Asn Ala 
1               5                   10              


<210>  114
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH3 of anti-CD33 antibody 4H10

<400>  114

Tyr Gly Tyr Asp Glu Arg Asn Ala Met Asp Tyr 
1               5                   10      


<210>  115
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL1 of anti-CD33 antibody 4H10

<400>  115

Gln Ser Leu Leu Tyr Ser Asn Gly Lys Thr Tyr Leu His 
1               5                   10              


<210>  116
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL2 of anti-CD33 antibody 4H10

<400>  116

Val Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu 
1               5                   10                  15      


<210>  117
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL3 of anti-CD33 antibody 4H10

<400>  117

Gly Thr His Phe Pro Arg Thr Phe Gly 
1               5                   


<210>  118
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH1 of anti-CD33 antibody 11D5

<400>  118

Gly Tyr Thr Phe Thr Ser Tyr Trp Met His 
1               5                   10  


<210>  119
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH2 of anti-CD33 antibody 11D5

<400>  119

Ala Ile Tyr Cys Gly Asn Ser Asp Thr Ser Tyr Asn Gln 
1               5                   10              


<210>  120
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH3 of anti-CD33 antibody 11D5

<400>  120

Tyr Asp Gly Tyr His Phe Asp Tyr 
1               5               


<210>  121
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL1 of anti-CD33 antibody 11D5

<400>  121

Arg Ser Asn Lys Ser Leu Leu His Ser Asn Gly Ile Thr Tyr Leu Tyr 
1               5                   10                  15      


<210>  122
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL2 of anti-CD33 antibody 11D5

<400>  122

Gln Met Ser Asn Leu Ala Ser 
1               5           


<210>  123
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL3 of anti-CD33 antibody 11D5

<400>  123

Ala Gln Asn Leu Glu Leu Pro Pro Thr 
1               5                   


<210>  124
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH1 of anti-CD33 antibody 13E11

<400>  124

Gly Tyr Thr Phe Thr Asp Tyr Thr Leu His 
1               5                   10  


<210>  125
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH2 of anti-CD33 antibody 13E11

<400>  125

Trp Phe Tyr Pro Thr Ser Gly Ser Ile Asn Tyr Asn Glu 
1               5                   10              


<210>  126
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH3 of anti-CD33 antibody 13E11

<400>  126

His Lys Phe Gly Phe Asp Tyr 
1               5           


<210>  127
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL1 of anti-CD33 antibody 13E11

<400>  127

Lys Ala Ser His Gly Val Glu Tyr Ala Gly Ala His Tyr Met Asn 
1               5                   10                  15  


<210>  128
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL2 of anti-CD33 antibody 13E11

<400>  128

Ala Ala Ser Asn Leu Gly Ser 
1               5           


<210>  129
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL3 of anti-CD33 antibody 13E11

<400>  129

Gln Gln Ser Asn Glu Asp Pro Arg Thr 
1               5                   


<210>  130
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH1 of anti-CD33 antibody 5E10.7

<400>  130

Gly Tyr Thr Phe Thr Ser Tyr Trp Met Gln 
1               5                   10  


<210>  131
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH2 of anti-CD33 antibody 5E10.7

<400>  131

Glu Ile Asp Ser Ser Asp Ser Tyr Thr Asn Tyr Asn Gln 
1               5                   10              


<210>  132
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH3 of anti-CD33 antibody 5E10.7

<400>  132

Ser Arg Pro Tyr Asp Trp Phe Pro Tyr 
1               5                   


<210>  133
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL1 of anti-CD33 antibody 5E10.7

<400>  133

Lys Ala Ser Gln Asp Ile Lys Ser Tyr Leu Ser 
1               5                   10      


<210>  134
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL2 of anti-CD33 antibody 5E10.7

<400>  134

Tyr Ala Thr Thr Leu Ala Asp 
1               5           


<210>  135
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL3 of anti-CD33 antibody 5E10.7

<400>  135

Leu His His Ser Glu Ser Pro Trp Thr 
1               5                   


<210>  136
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH1 of anti-CD33 antibody 11D11

<400>  136

Ser Gly Phe Thr Phe Ser Asp Phe Tyr Met Glu 
1               5                   10      


<210>  137
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH2 of anti-CD33 antibody 11D11

<400>  137

Ala Ser Arg Asn Lys Ala Asn Asp Tyr Thr Thr Glu Tyr 
1               5                   10              


<210>  138
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH3 of anti-CD33 antibody 11D11

<400>  138

Asp Thr Gly Pro Met Asp Tyr 
1               5           


<210>  139
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRHL1 of anti-CD33 antibody 11D11

<400>  139

Arg Ala Ser Gln Asp Ile Ser Asn Tyr Leu Asn 
1               5                   10      


<210>  140
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRHL2 of anti-CD33 antibody 11D11

<400>  140

Tyr Thr Ser Arg Leu His Ser 
1               5           


<210>  141
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRHL3 of anti-CD33 antibody 11D11

<400>  141

Gln Gln Gly Ser Thr Leu Pro Pro Thr 
1               5                   


<210>  142
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH1 of anti-CD33 antibody 7E7

<400>  142

Gly Phe Ser Leu Asn Ser Tyr Gly Met Gly Ile Gly 
1               5                   10          


<210>  143
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH2 of anti-CD33 antibody 7E7

<400>  143

His Ile Trp Trp Asp Asp Asn Lys Tyr Tyr Lys Pro Asp Leu Lys Ser 
1               5                   10                  15      


<210>  144
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH3 of anti-CD33 antibody 7E7

<400>  144

Asp Gly Gly Tyr Ser Leu Phe Ala Tyr 
1               5                   


<210>  145
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL1 of anti-CD33 antibody 7E7

<400>  145

Lys Ser Ser Gln Ser Leu Leu Asp Ser Asp Gly Lys Thr Tyr Leu Ser 
1               5                   10                  15      


<210>  146
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL2 of anti-CD33 antibody 7E7

<400>  146

Val Ser Lys Leu Asp Ser Gly 
1               5           


<210>  147
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL3 of anti-CD33 antibody 7E7

<400>  147

Trp Gln Gly Thr His Phe Pro Leu Thr 
1               5                   


<210>  148
<211>  10
<212>  PRT
<213>  Mus musculus

<400>  148

Gly Tyr Thr Phe Thr Asp Tyr Asp Met His 
1               5                   10  


<210>  149
<211>  15
<212>  PRT
<213>  Mus musculus

<400>  149

Ala Ile Asp Pro Glu Thr Gly Gly Thr Ala Tyr Asn Gln Asn Phe 
1               5                   10                  15  


<210>  150
<211>  7
<212>  PRT
<213>  Mus musculus

<400>  150

Asp Tyr Asp Tyr Phe Gly Val 
1               5           


<210>  151
<211>  11
<212>  PRT
<213>  Mus musculus

<400>  151

Lys Ala Ser Gln Asn Val Gly Thr Asn Val Val 
1               5                   10      


<210>  152
<211>  7
<212>  PRT
<213>  Mus musculus

<400>  152

Ser Ala Ser Asp Arg Tyr Ser 
1               5           


<210>  153
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  153

Gln Gln Tyr Asn Ile Tyr Pro Tyr Thr 
1               5                   


<210>  154
<211>  128
<212>  PRT
<213>  Mus musculus

<400>  154

Met Glu Ser Gln Thr Gln Val Phe Val Tyr Met Leu Leu Trp Leu Ser 
1               5                   10                  15      


Gly Val Asp Gly Asp Ile Val Met Thr Gln Ser Gln Lys Phe Met Ser 
            20                  25                  30          


Thr Ser Val Gly Asp Arg Val Ser Val Thr Cys Lys Ala Ser Gln Asn 
        35                  40                  45              


Val Gly Thr Asn Val Val Trp Tyr His Lys Lys Pro Gly Gln Ser Pro 
    50                  55                  60                  


Lys Gly Leu Ile Tyr Ser Ala Ser Asp Arg Tyr Ser Gly Val Pro Asp 
65                  70                  75                  80  


Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Asn 
                85                  90                  95      


Asn Val Gln Ser Glu Asp Leu Ala Glu Tyr Phe Cys Gln Gln Tyr Asn 
            100                 105                 110         


Ile Tyr Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg 
        115                 120                 125             


<210>  155
<211>  135
<212>  PRT
<213>  Mus musculus

<400>  155

Met Glu Trp Ser Trp Val Cys Leu Phe Leu Leu Ser Val Ile Ala Gly 
1               5                   10                  15      


Val Gln Ser Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg 
            20                  25                  30          


Pro Gly Ala Ser Val Thr Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
        35                  40                  45              


Thr Asp Tyr Asp Met His Trp Val Lys Gln Thr Pro Val His Gly Leu 
    50                  55                  60                  


Glu Trp Ile Gly Ala Ile Asp Pro Glu Thr Gly Gly Thr Ala Tyr Asn 
65                  70                  75                  80  


Gln Asn Phe Lys Gly Lys Ala Ile Leu Thr Val Asp Lys Ser Ser Arg 
                85                  90                  95      


Ile Ala Tyr Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val 
            100                 105                 110         


Phe Tyr Cys Thr Ser Asp Tyr Asp Tyr Phe Gly Val Trp Gly Thr Gly 
        115                 120                 125             


Thr Thr Val Thr Val Ser Ser 
    130                 135 


<210>  156
<211>  44
<212>  PRT
<213>  Artificial sequence

<220>
<223>  engingeered protein containing signal peptide from full length 
       CD33 fused to c-terminal end of CD33deltaE2

<400>  156

Met Pro Leu Leu Leu Leu Leu Pro Leu Leu Trp Ala Gly Ala Leu Ala 
1               5                   10                  15      


Met Asp Leu Thr His Arg Pro Lys Ile Leu Ile Pro Gly Thr Leu Glu 
            20                  25                  30          


Pro Gly His Ser Lys Asn Leu Thr Cys Ser Val Ser 
        35                  40                  


<210>  157
<211>  48
<212>  PRT
<213>  Artificial sequence

<220>
<223>  engingeered protein containing signal peptide from CD33deltaE2 
       fused to c-terminal end of full length CD33

<400>  157

Met Pro Leu Leu Leu Leu Leu Pro Leu Leu Trp Ala Asp Leu Thr His 
1               5                   10                  15      


Arg Pro Lys Ile Leu Ile Pro Asn Phe Trp Leu Gln Val Gln Glu Ser 
            20                  25                  30          


Val Thr Val Gln Glu Gly Leu Cys Val Leu Val Pro Cys Thr Phe Phe 
        35                  40                  45              


